LOCUS 048_IIG_Bs27_035_SNP 3374031 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1f7-cvskbtu VERSION urn.local...1f7-cvskbtu KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3373921..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 226633..226634 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_026" CDS 226647..227522 /gene="cesB" /locus_tag="PG10_pseudo_BSU02260" /old_locus_tag="BSU_02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /modified_by="User" /translation="MQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKTHIIAS GPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAMETRADF AEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFISFHPDV YKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTENGFPYV FTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLSLEQPE YVNQRVLSFLCGGIK*" /label="PG10_pseudo_BSU02260" gene 226647..227522 /gene="cesB" /locus_tag="PG10_pseudo_BSU02260" /old_locus_tag="BSU_02260" /modified_by="User" /label="PG10_pseudo_BSU02260" promotor_-35 226866..226873 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 226882 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 226887..226905 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 227523..227717 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 227718..228251 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 227718..228251 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 228242..228730 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 228242..228730 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 228723..229514 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 228723..229514 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 229489 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 229569..229847 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 229569..229847 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 229890..229899 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 229908 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 229912..229927 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 229953..231293 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 229953..231293 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 231293 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 231359 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 231362..231381 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 231401..232288 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 231401..232288 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 232289..232432 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 232404..232411 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 232425..232444 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 232434 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 232488..233456 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 232488..233456 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(233310..233328) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(233327) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(233344..233349) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 233453 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(233492) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(233492..234736) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(233492..234736) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(234770..234788) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234779) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234799..234807) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(234807..234825) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234823) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234841..234846) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(234881..236776) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(234881..236776) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(234897) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 236642..236661 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 236659 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(236797..237546) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(236797..237546) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 237519..237700 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(237547..237617) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(237606..237625) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(237621) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(237641..237648) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 237687..237694 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 237702 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 237707..237726 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 237765..238472 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 237765..238472 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 238438..238439 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 238455..238469 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 238465 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 238506..238781 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 238506..238781 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(238564..238582) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(238570) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(238597..238603) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 238773 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 238824..238828 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 238844..238863 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 238850 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 238861..238989 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 238990..240060 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 238990..240060 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 240049 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(240097..241509) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(240097..241509) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(240114) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(241510..241621) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(241594..241613) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(241621) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(241628..241635) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(241630..242577) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(241630..242577) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(242615..242634) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(242632) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(242649..242656) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(242706..244142) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(242706..244142) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(242721) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(244165..245148) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(244165..245148) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(245242..245259) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 245247..245266 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(245249) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 245253 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(245275..245282) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 245450..246682 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 245450..246682 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 246693..247637 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 246693..247637 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 247614 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 247734..247741 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 247746..247863 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 247746 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 247755..247774 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 247864..248790 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 247864..248790 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 248820..250286 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 248820..250286 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 250370..251737 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 250370..251737 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 251774..253141 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 251774..253141 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 253155..253162 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 253177..253194 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 253180 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 253211..253912 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 253211..253912 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 253862 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 253906 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 254003..255535 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 254003..255535 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 255547..255550 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 255565..255584 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 255577..255811 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 255577 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 255812..256732 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 255812..256732 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 256734..256741 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 256756..256775 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 256766 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 256789..257036 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 256789..257036 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 257005 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 257134..257295 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 257134..257295 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 257212..257312 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 257272 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 257316..258254 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 257316..258254 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 257360 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 258277..258296 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 258282..258350 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 258282 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 258351..259031 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 258351..259031 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 259033..259968 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 259033..259968 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 260060..260983 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 260060..260983 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(260530..261714) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 261002..261688 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 261002..261688 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(261649..261783) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(261649..261783) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 261683 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(261743..262129) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(261743..262129) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(261759) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(262155..262173) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(262174) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(262187..262193) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(262207..263205) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(262250) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 262386..262391 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 262405 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 262407..262425 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(262419) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(262421..262435) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(262441) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(262443..262447) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 262443..262871 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 262443..262871 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 262850 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 262916..262922 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 262935..262954 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 262937 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 262977..263708 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 262977..263708 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(263179..263198) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263205) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263212..263219) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 263626 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 263790..263966 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 263790..263966 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 263918..263924 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 263931..263948 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 263942 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 263985..265736 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 263985..265736 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(264039..264054) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264045) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264067..264076) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 265749..265961 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 265749..265961 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 265962..266021 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 266022..266750 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 266022..266750 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(266030) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(266747..267394) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(266747..267394) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(267409..267428) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 267422..267428 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(267423) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(267443..267447) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 267443..267462 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 267445 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 267473..268585 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 267473..268585 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(267819) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(267822..267841) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(267857..267861) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 268579 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(268627..270066) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(268627..270066) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(268634) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(270106..270672) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(270106..270672) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(270710..270729) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(270724) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(270744..270751) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 270826..270832 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 270848..270865 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 270854 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 270889..272016 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 270889..272016 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 271989 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 272113..272119 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272133..272152 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272133 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 272179..272817 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 272179..272817 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 272803 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 272848..273438 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(272855..273238) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(272855..273238) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(272879) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(273052,273054) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(273268..273287) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(273275) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(273301..273308) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 273410..273413 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273429..273448 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273440 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273473..274549 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 273473..274549 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 274543 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(274589..275545) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(274589..275545) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(274617) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(275558..276259) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(275558..276259) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(276283..276302) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(276289) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(276318..276321) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 276339..276342 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 276358..276377 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 276368 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 276403..277143 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 276403..277143 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 277144..278304 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 277144..278304 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 278355..278363 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 278375..278393 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 278375 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 278440..279372 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 278440..279372 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(279412..280476) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(279412..280476) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(279413) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(280477..280667) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(280499..280630) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(280499..280630) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(280652..280671) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(280672) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(280686..280693) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 280804..282222 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 280804..282222 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(282265..282283) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282273) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282297..282304) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 282329..282408 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 282329 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 282331..282337 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 282352..282369 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 282409..283770 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 282409..283770 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 283771..284351 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(283778..284281) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(283778..284281) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(284282..284363) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 284353 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(284355..284374) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 284356..284375 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(284364) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 284404..285525 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 284404..285525 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 285519 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 285566..285572 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 285587..285605 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 285590 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 285632..286408 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 285632..286408 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(285639) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 286433..288118 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 286433..288118 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 287373..287473 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 287433 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 287499 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 288115 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 288209..288216 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 288232..288251 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 288238 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 288306..289265 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 288306..289265 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 288861..288867 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 288881..288900 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 288885 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 289237 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 289321..290016 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 289321..290016 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 289974..290816 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 289974..290816 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 290803 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(290854..291849) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(290854..291849) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 291805..291812 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 291827..291846 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 291833..292035 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 291833 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(291881..291900) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(291889) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(291915..291922) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 292019..292028 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 292037..292132 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 292037 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 292041..292056 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 292133..292732 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 292133..292732 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 292754..293335 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 292754..293335 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 293370..293948 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 293370..293948 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 293999..294772 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 293999..294772 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 294759 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 294857..296470 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 294857..296470 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 296486..297577 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 296486..297577 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 297551 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 297631..297638 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 297653..297672 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 297661 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 297699..298901 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 297699..298901 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 298881 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(299154..300326) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(299154..300326) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(299169) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(300395..300697) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(300395..300697) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(300423) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(300680..300699) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(300699) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(300713..300719) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 300946..300965 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 300946 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 300987..302243 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 300987..302243 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(300995) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 302245..303093 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 302245..303093 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 303093..303974 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 303093..303974 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 303955 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(303987) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(304012..305163) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(304012..305163) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(304031) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(305164..305251) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 305219..305226 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(305238..305257) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 305241..305260 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(305251) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 305254 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(305270..305276) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 305313..306746 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 305313..306746 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 306051..306059 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 306071..306089 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 306090 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 306728 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 306789..306796 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 306811..306830 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 306820 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 306862..307443 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 306862..307443 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 307256 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 307260..307264 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 307419..307426 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307441..307460 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 307454..307591 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 307454 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 307592..309571 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 307592..309571 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 309585 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 309651..309658 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 309668 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 309672..309691 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 309748..310713 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 309748..310713 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 310745..312370 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 310745..312370 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 310751 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 312357 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(312415..313953) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(312415..313953) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(312433) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(313007..313107) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(313047) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 313967..313971 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 313987..314006 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 314001 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(314033..314052) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(314036) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 314066..314530 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 314066..314530 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(314067..314073) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 314540..314545 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 314561..314579 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 314571 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 314604..315233 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 314604..315233 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 315244..315253 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315267..315286 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315275 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 315303..316064 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 315303..316064 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(315703..316065) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 316061 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(316066..317406) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(316066..317406) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(317433..317444) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(317443) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(317459..317465) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 317485..317491 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 317499 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 317506..317517 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 317536..318132 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 317536..318132 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 318140..318147 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 318161..318261 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 318161..318180 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 318161 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(318257) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 318262..319080 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 318262..319080 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 319062 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(319130..319723) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(319130..319723) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(319137) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(319738..319757) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319753) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319772..319775) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(319781..319929) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 319831..319838 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 319851..319870 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 319853..319961 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 319855 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(319923..319941) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 319929..319936 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(319939) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319951..319970 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(319957..319962) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319963 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 319999..320559 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 319999..320559 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 320536 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(320587..321348) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(320587..321348) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(320611) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(321380..321399) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321381..321388 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321386) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321403..321422 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321414..321419) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321415 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 321466..322440 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 321466..322440 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 322441..322511 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 322512..323468 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 322512..323468 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 322927..322933 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 322948..322959 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 322955 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 323469..323547 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 323522..323527 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 323544..323562 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 323549 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 323552..324334 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 323552..324334 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 324299 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 324344..324471 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 324448..324452 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324467..324486 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324473 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 324525..325436 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 324525..325436 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 325453..327000 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 325453..327000 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 326424..326430 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326444..326463 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326452 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 326535..326541 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326554..326573 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326563 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 326999..327003 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 327001..327123 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 327003 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 327124..328545 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 327124..328545 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(327644..329499) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 328525 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 328570..328666 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 328637..328644 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328659..328678 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328668 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328698..329933 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 328698..329933 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(329492..329510) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(329509) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(329524..329531) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(329917) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(329970..330827) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(329970..330827) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(329983) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(330832..331716) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(330832..331716) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(331768) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(331773..331786) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(331801..331809) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(331816..332670) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(331816..332670) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(332689..332708) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(332709) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(332723..332726) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 332760..332779 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(332760..332778) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 332767..332831 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 332768 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(332777) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(332794..332799) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 332832..333842 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 332832..333842 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 333843..336290 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(333874..335325) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(333874..335325) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(333878) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(335386..335706) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(335386..335706) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 335557..335562 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 335576..335580 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 335583 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(335615) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(335617..335636) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(335650..335657) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(335738..338155) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(335738..338155) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(338180..338199) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(338194) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(338211..338217) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(338277..340409) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(338277..340409) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(340416..342731) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(340416..342731) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(342750..342850) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(342790) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 342833..342840 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 342854..342873 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 342866 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 342911..344116 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 342911..344116 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 344101 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 344160..344166 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 344181..344200 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 344189 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 344233..345147 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 344233..345147 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 345144..345728 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 345144..345728 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 345739..345746 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 345760..345779 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 345770 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 345824..346009 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 345824..346009 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 346037..347230 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 346037..347230 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 347222 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 347267..348936 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(347279..347959) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(347279..347959) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(347285) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(347969..348832) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(347969..348832) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(348854..348873) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(348866) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(348868..351702) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(348888..348895) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 348905..348911 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 348926..348944 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 348938..349160 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 348938 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 348994..349191 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 348994..349191 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 349129..349134 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 349150..349168 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 349162 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 349210..349665 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 349210..349665 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 349640 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 349688..349694 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 349701 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 349708..349719 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 349747..350079 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 349747..350079 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 350060 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 350165..350172 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350188..350207 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350192 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 350233..351666 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 350233..351666 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 351644 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(351703..352101) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(351703..352101) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(352098..352198) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(352128..352577) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(352128..352577) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(352138) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(352592..352611) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(352600) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(352602..352744) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(352625..352632) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(352745..354466) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(352745..354466) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 352757..352764 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 352775..355918 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 352775 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 352779..352798 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(352780..352880) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(352820) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(354490..354508) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(354505) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(354522..354529) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(354577..355134) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(354577..355134) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(354580) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(355140..355772) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(355140..355772) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(355798..355817) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(355813) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(355832..355835) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 355896..355899 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 355914..355933 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 355920 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 356006..356368 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 356006..356368 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 356352 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 356615..356618 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 356633..356652 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 356641..356941 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 356641 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 356942..367705 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 356942..367705 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 367718..378469 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 367718..378469 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 370854..370994 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 370854..370994 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 378506..382333 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 378506..382333 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 382362..383090 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 382362..383090 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 383072 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 383128..383135 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 383138 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 383147..383166 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 383191..384417 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 383191..384417 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 384411 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(384432..384989) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(384432..384989) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(384447..384547) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(384469) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(384487) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(385018..385037) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(385020) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(385043..385981) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(385043..385981) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(386020..386038) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(386027) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(386054..386059) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 386105..387439 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 386105..387439 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(387434..387601) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(387434..387601) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(387612..388109) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(387612..388109) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(388136..388155) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(388148) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(388214..388861) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(388214..388861) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(388890..388909) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(388893) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(388925..388929) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(389030..389181) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(389182..389925) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(389182..389925) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(389238) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(389939..390643) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(389939..390643) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(390630..391436) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(390630..391436) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(391485..391504) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(391497) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(391518..391525) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(391552..392424) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(391552..392424) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(392162..392180) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(392169) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(392195..392201) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 392478..392485 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(392493..392512) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 392499..392518 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(392499) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 392507 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 392514..393128 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 392514..393128 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(392526..392533) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 393131..394552 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 393131..394552 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 394569..394796 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 394569..394796 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 394793..395257 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 394793..395257 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 395238 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 395264..395265 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 395265 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 395324..396169 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 395324..396169 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(396209..397687) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(396209..397687) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(396217) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 397714..397716 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(397715..397734) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 397725 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 397733..397751 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(397735) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(397737..>397920) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(397749..397756) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 397905..397914 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 397920..397921 /note_="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_011" downshifts 397926 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(397936..399375) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(397936..399375) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(398260..398271) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(398266) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(398285..398291) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399418..399437) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 399419..399426 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(399425) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399440..399459 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399444 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399448..399455) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 399482..400792 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 399482..400792 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 400670..400676 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 400690..400708 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 400698 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 400794..400801 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 400816..400835 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 400825 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 400861..402249 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 400861..402249 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 402257 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 402307..402313 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402327..402338 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402328 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 402372..403235 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 402372..403235 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 403255..404040 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 403255..404040 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 403360..403379 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 403360 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 403448 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 404042 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(404085..404699) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(404085..404699) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(404096) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(404712..406337) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(404712..406337) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(406372..406944) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(406372..406944) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(406966..406985) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(406981) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(406999..407006) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 407066..407085 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 407078 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 407109..407462 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 407109..407462 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 407433 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 407526..407533 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 407547..407566 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 407552 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 407562..407634 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 407635..409071 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 407635..409071 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 409096..409527 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 409096..409527 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 409529..410650 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 409529..410650 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 410633 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 410679..410682 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 410698..410717 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 410700 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 410741..411805 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 410741..411805 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 410975..410983 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 410997..411016 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411007 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 411799 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 411872..411879 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411892..411911 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411905 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 411940..412503 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 411940..412503 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 412504..413228 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(412563..413171) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(412563..413171) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(413189..413208) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 413205..413211 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(413212) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 413224..413243 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413230 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 413257..413649 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 413257..413649 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 413626 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(413682..413846) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(413682..413846) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(413702) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(413856..413874) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413878) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413889..413895) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413908..413915 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413929..413948 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413932 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 413979..414728 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 413979..414728 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 414705 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(414781) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 414811..414817 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 414831..414850 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 414837..414933 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 414837 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 414934..415707 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 414934..415707 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 415722..416936 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 415722..416936 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 416960..417733 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 416960..417733 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 417778..418500 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 417778..418500 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 418503..419510 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 418503..419510 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 418996 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 419090..419190 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 419150 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 419526..420278 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 419526..420278 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 420276..420285 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 420299..420318 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 420309 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 420342..420983 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 420342..420983 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 420969 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(420981..421406) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(421026) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 421059..421065 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421079..421098 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421080 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 421156..421401 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 421156..421401 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 421402..421812 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(421407..421694) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(421407..421694) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(421715..421734) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(421731) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 421788..421792 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421809..421828 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421814 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 421845..423851 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 421845..423851 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 423852..423952 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 423953..424855 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 423953..424855 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 424835 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 424928..424935 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424949..424968 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 424953..425040 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 424953 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 425041..427125 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 425041..427125 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 427112 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 427154..427160 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 427174..427192 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 427186 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 427197..427278 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 427240..427247 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 427261..427280 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 427280 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 427337..428848 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 427337..428848 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 428832 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(428868..429413) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(428868..429413) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(428901) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(429480..429498) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(429494) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(429513..429519) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 429555..429561 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 429573 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 429576..429594 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 429620..430480 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 429620..430480 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 430496..430999 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 430496..430999 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 430980 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 431028..431035 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431049..431068 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431051 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 431085..431636 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 431085..431636 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 431651..431657 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431672..431690 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431685 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 431714..432136 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 431714..432136 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 432141..432149 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432160..432179 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 432179..432545 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 432179 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(432205..432305) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(432240..432508) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(432240..432508) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(432245) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 432502 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 432582..432591 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432604..432619 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 432609 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 432642..433451 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 432642..433451 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 433432 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(433495..433785) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(433495..433785) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(433499) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(433813..433832) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 433813..433831 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 433819 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(433829) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 433907..433914 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 433928..433947 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 433932 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 433970..434404 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 433970..434404 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 434401..434404 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 434413 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 434421..434440 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 434469..436652 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 434469..436652 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 436635 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 436701..436707 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 436722..436740 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 436723..436854 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 436723 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 436855..437943 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 436855..437943 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 437924..438775 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 437924..438775 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 438786..440495 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 438786..440495 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 440488..441750 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 440488..441750 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 441756..443867 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 441756..443867 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 443851 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 443964..443971 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443986..444005 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443993 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 444003..444146 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 444003..444146 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 444144 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 444189..444342 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 444343..446166 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 444343..446166 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 446158 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 446225..446674 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 446225..446674 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 446687..446693 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 446708..446726 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 446709 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 446741..448465 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 446741..448465 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(447577..448436) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(448438..448549) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 448449 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(448457..448660) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(448457..448660) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(448481) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(448509..448609) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 448518..448523 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448540..448558 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(448549) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 448550..448765 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 448550 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(448616..448687) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(448659) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(448688..448954) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(448688..448954) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(448970..448989) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(448988) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(449001..449008) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(449058..450335) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(449058..450335) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(449077) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(450397..450416) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450409) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(450411..450488) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(450429..450436) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(450472..450491) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450488) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(450505..450514) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(450565..450822) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(450565..450822) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(450573) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(450639) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(450900..451352) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(450900..451352) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(451371..451389) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(451388) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(451403..451409) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 451421 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 451429..451448 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 451470..452288 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 451470..452288 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 452279 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 452356..452362 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 452376..452394 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 452384 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 452417..452788 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 452417..452788 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(452421) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 452805 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(452839) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(452842..452845) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 452867..452874 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 452886..452905 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 452893 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 452920..453261 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 452920..453261 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 453255..453614 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 453255..453614 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(453317..453610) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 453555 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 453599 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(453651..454472) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(453651..454472) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(453655) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(454494..454512) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(454515) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(454526..454532) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(454557..455609) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(454557..455609) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 454869..454876 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 454891..455678 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 454891..454910 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454892 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(455622..455641) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(455627) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(455655..455662) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 455679..457286 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 455679..457286 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 457276..457956 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 457276..457956 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 457957..458031 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 457998..458005 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 458020..458037 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 458033 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 458077..459342 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 458077..459342 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 459335 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(459389) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 459426..459443 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 459428 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 459490..460542 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 459490..460542 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 460543..460786 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 460743 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 460819..461745 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 460819..461745 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 461765..462505 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 461765..462505 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 462564..462583 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 462569 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 462600..462935 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 462600..462935 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 462910 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 462955..463024 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 462990..462997 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 463011..463030 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 463025 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 463063..464208 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 463063..464208 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 464190 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(464233..464412) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(464233..464412) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(464251) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(464366..464530) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(464366..464530) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(464413..464581) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(464573..464592) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(464583) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(464607..464614) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 464722..464727 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 464743..464761 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 464747 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 464777..465649 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 464777..465649 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 465013..465022 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 465035..465050 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 465038 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(465594..465663) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(465637) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 465650..465999 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(465664..465984) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(465664..465984) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 465980..465984 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 465993..466007 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 466001..466158 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 466001 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(466005..466024) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(466020) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(466038..466045) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 466159..467223 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 466159..467223 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 467211 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 467295..468668 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 467295..468668 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 468699..468705 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468719..468730 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 468729 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 468772..468791 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 468773..468947 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 468773 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 468915..468922 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468937..468956 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 468949..469016 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 468949 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 469068..470552 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 469068..470552 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 470545 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 470665..470724 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 470665..470674 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 470667 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 470686..470701 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 470725..471204 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 470725..471204 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 471194..472675 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 471194..472675 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 472645 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 472690..473017 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(472699) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(472927..473526) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(472927..473526) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 472987..472992 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 473005..473024 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 473019..473620 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 473019 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(473550..473569) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(473561) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 473621..473986 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 473621..473986 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 473989..473994 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 474010..474151 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 474010..474028 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 474010 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 474152..475168 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 474152..475168 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 475153 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 475213..475220 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 475234..475253 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 475241 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 475283..476452 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 475283..476452 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 476381..476386 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476401..476419 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476407 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 476482..476485 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476501..476520 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476502 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 476568..476849 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 476568..476849 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 476854..477204 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 476854..477204 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(476994..477470) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(477037) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 477184 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 477238..477245 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 477259..477278 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 477267 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 477319..478143 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 477319..478143 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(477453..477471) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(477470) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(477472..478071) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(477485..477492) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(478060..478078) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478071) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(478073..478661) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(478092..478098) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 478148..478513 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 478148..478513 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 478517..478918 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 478517..478918 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(478659..478678) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478676) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478692..478701) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 478930..479937 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 478930..479937 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 479931..479937 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 479952..479970 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 479958 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 479999..480328 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 479999..480328 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 480325..480807 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 480325..480807 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 480773..481561 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 480773..481561 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 481561..482160 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 481561..482160 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 482146 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 482204..482210 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482225..482244 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(482233,482235) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 482237 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 482271..482387 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 482271..482387 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 482403..482696 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 482403..482696 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 482664..482672 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482684..482703 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 482693..483133 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 482693..483133 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 482699 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(482932..485987) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 483117..483560 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 483117..483560 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 483535 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 483591..483592 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 483608..483627 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 483608 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 483654..485813 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 483654..485813 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 485801..485820 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 485823..486039 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 485823 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(485823..485936) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(485823..485936) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(485976..485995) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(485993) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(486010..486018) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 486040..486492 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 486040..486492 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 486498..486504 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486519..486538 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 486527..486614 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 486527 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(486559) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 486615..486689 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 486615..486689 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 486694..486784 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 486694..486784 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 486814..486885 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 486814..486885 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 486897..486971 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 486897..486971 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 486998..487073 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 486998..487073 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 487085..487166 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 487085..487166 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 487231 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 487247..>487332 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 487247..>487332 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 487332..487333 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<487333..487639) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 487352 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(487384) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(487640..488659) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(487640..488659) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(488335..488354) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488348) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488369..488376) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488448..488452 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488469..488488 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488473 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 488474..488918 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 488919..489329 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 488919..489329 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 489330..489399 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 489356 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(489452..489901) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(489452..489901) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 490016..490558 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 490016..490558 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 491031..491035 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 491052..491071 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 491061 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 491111..491875 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 491111..491875 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 492069..493379 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 492069..493379 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 493402..493961 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 493962..494138 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 493962..494138 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 494163..494849 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 494163..494849 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 495191..495195 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 495210..495229 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 495218 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(495265,495267) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 495274..495459 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 495274..495459 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 495458 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 495809..496402 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 495809..496402 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 496515..496522 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496536..496555 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496547..496664 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 496547 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(496582) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 496665..496865 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 496665..496865 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(496763..497551) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 496768 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 496869 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(496933..497011) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(496933..497011) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(497552..498013) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(497552..498013) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 498022..498567 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(498065) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(498072..498091) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(498107..498114) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 498534 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(498581..498817) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(498581..498817) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(498915..499790) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(498915..499790) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 499903..500862 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 499903..500862 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(499924) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(499928..499947) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(501015..501887) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(501015..501887) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(501980..501985) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(501987..501988) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(501992) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 502061..502067 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 502075 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 502081..502100 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 502114..503502 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 502114..503502 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 503478 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 503612..504904 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 503612..504904 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 504913..504919 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 504934..504953 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 504941 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 504952..505062 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 505063..505509 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 505063..505509 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 505538 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 505589..505596 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505611..505630 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 505612 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 505746..506339 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 505746..506339 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 506382 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(506458) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 506471..506478 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 506492 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 506493..506512 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(506691..507350) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(506691..507350) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(507399..507418) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(507406) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(507430..507435) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(507772..508635) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(507772..508635) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 508678..508684 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 508699..508718 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(508700..508719) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 508714 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(508724) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(508734..508741) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 508790..510181 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 508790..510181 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 510309..510316 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 510327..510346 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 510341 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 510375..510800 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 510375..510800 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 510801..512055 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(510853..511425) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(510853..511425) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(510858) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(511426..511506) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(511507..511836) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(511507..511836) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(511853..511872) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(511870) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 512044..512063 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 512057 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 512091..512963 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 512091..512963 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 512850 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 513048 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(513113..513499) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(513113..513499) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(513125) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(513500..513564) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 513552..513559 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(513553..513572) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(513566) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 513573..513592 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 513576 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(513587..513594) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 513610..514203 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 513610..514203 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(514347..515534) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(514347..515534) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 515670..515674 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 515688 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 515689..515708 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 515738..516334 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 515738..516334 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 516448..516633 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 516448..516633 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 516612 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 516745..516748 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 516755..516941 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 516755 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 516763..516782 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 516942..517277 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 516942..517277 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 517290..518597 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 517290..518597 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 518629..518733 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 518629..518733 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 518742..518855 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 518742..518855 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 519041..519049 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 519060..519078 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 519077 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 519095..519880 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 519095..519880 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 519142 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 519890 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(519937..520857) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(519937..520857) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 520990..522438 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 520990..522438 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(522556..523179) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(522556..523179) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(523203..523222) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 523211..523218 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(523222) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 523233..523252 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 523235 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(523237..523243) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 523269..523949 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 523269..523949 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 523982 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(524029..524472) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(524029..524472) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(524034) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(524495..524514) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(524519) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(524528..524535) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(524558..524737) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(524558..524737) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(524734..524877) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(524734..524877) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 524828..524830 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 524846..524865 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 524862 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 525145..526368 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 525145..526368 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 526361..527002 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 526361..527002 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 526996 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(527029..527048) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(527050) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(527062..527069) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 527110..527115 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 527118..529292 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 527118..529292 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 527128 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 527130..527148 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(528194..528212) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(528194) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(529296..529703) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 529313..529317 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 529327 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 529330..529349 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(529341) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(529704..530606) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(529704..530606) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(530607..530702) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(530682..530701) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(530702) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(530715..530722) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(530808..531497) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(530808..531497) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(531587..532399) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(531587..532399) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(532428..532447) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532441) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532463..532470) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(532510..533403) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(532510..533403) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(532530) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(533404..533496) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(533477..533496) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(533494) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(533512..533519) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 533685..533692 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 533707..533726 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 533713 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 533879..534499 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 533879..534499 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 534223..534229 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 534234 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 534243..534261 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 534515..535453 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 534515..535453 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 535441..535444 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 535459..535478 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 535466..535554 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 535466 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 535555..535944 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 535555..535944 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 535935 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 536058..536077 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 536060..536129 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 536060 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 536130..536468 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 536130..536468 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 536456 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536508..536744) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(536508..536744) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(536532) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 536556..536562 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 536577..536588 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 536588 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(536745..536906) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(536910..537275) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(536950) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(537276..537506) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(537276..537506) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 537490 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(537527..537546) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537544) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(537546..537629) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(537560..537569) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(537630..538307) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(537630..538307) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(538278..538289) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(538292) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(538304..538310) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(538308..539141) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 538323..538328 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 538343..538354 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 538348 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 538420..539127 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 538420..539127 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(539142..539573) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(539142..539573) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(539586..539828) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(539586..539828) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(539842..540114) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(539842..540114) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(540136..540155) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(540140) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(540169..540178) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 540333..540340 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 540356..540375 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 540364 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 540413..541000 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 540413..541000 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 540997..541341 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 540997..541341 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 541342..541503 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 541504..541977 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 541504..541977 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 541978..542670 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(542120) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(542137..543780) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(542137..543780) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(543815..544012) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 543829..543831 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 543848..543866 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 543852 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(543858) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 543978 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(544004..544023) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(544016) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(544036..544043) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(544099) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(544100..545476) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(544100..545476) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(545526..545545) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(545541) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(545615,545617) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 545616..545649 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(545648..546166) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(545648..546166) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(545662) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(546192..546211) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(546211) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546227..546230) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 546248..546255 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 546270..546289 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546288 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(546300..546701) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(546300..546428) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(546300..546701) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(546300..546428) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 546318..546410 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 546318..546410 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 546320..546321 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(546632..546826) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(546632..546826) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(546859..546870) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(546867) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546884..546890) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 546945..546952 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 546966..546985 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 546968..547068 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 546970 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(547016) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 547028 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 547036..547043 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 547057..547076 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 547072..547159 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 547072 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 547160..547236 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 547160..547236 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 547250..547323 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 547250..547323 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 547483..549037 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 547483..549037 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 549205..552132 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 549205..552132 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 552188..552304 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 552188..552304 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 552318..552394 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 552318..552394 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 552455..552531 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 552455..552531 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 552528 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 552632..552636 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 552652..552671 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 552656 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 552712..553689 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 552712..553689 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 553704..554180 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 553704..554180 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 554161..554850 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 554161..554850 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 554860..555315 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 554860..555315 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 555308..556348 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 555308..556348 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 556312 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(556578..558506) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(556578..558506) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(556595) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 558258..558277 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 558268 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 558270..558459 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 558424..558431 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 558445..558464 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 558461..558631 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 558461 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(558526..558545) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(558538) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(558559..558566) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 558632..559144 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 558632..559144 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 559141..559788 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 559141..559788 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 559618..559718 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 559678 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 559810..559983 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 559810..559983 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 559990..560754 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 559990..560754 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 560734 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560792..560983) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(560792..560983) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(560809) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(560980..561714) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(560980..561714) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 561372..561377 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561392..561410 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 561394 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 561713..561714 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 561724..561738 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 561746 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(561751..561770) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 561768..561876 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(561771) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561784..561789) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 561850..561856 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561870..561889 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 561878..561952 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 561878 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 561953..562237 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 561953..562237 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 562284..563918 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 562284..563918 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 563919..564011 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 563968 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(564006..564134) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(564006..564134) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 564013..>565239 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(564137..564295) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(564137..564295) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(564340..564468) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(564340..564468) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(564561..564770) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(564561..564770) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(564763..565068) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(564763..565068) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(565239,565246) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 565240..565245 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(565344..567833) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(565344..567833) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(565366) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567847..567866) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567873) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567880..567887) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 567936..567937 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 567952..568034 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 567952 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 567953..567972 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 568035..569096 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 568035..569096 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 569170..570561 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 569170..570561 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 570588..570595 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570609..570628 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 570614 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 570656..571618 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 570656..571618 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 571603 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 571743..571752 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 571759 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 571765..571780 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 571814..572497 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 571814..572497 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 572498..572562 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 572563..573588 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 572563..573588 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 573588..574352 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 573588..574352 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 574383..575354 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 574383..575354 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 575344 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 575388 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(575401..576426) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(575401..576426) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(576458..576477) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(576476) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(576491..576497) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 576686..576693 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 576706 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 576708..577010 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 576708..576727 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 577011..578432 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 577011..578432 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 578424 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(578480) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(578480..579520) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(578480..579520) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 579060..579069 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 579083..579102 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 579084..579619 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 579084 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(579521..579815) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 579620..579639 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 579621..579918 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 579621 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(579810..579824) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(579815) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 579917..579936 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 579920 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 579959..580330 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 579959..580330 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 580316 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 580396..581442 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 580396..581442 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 581416 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(581476..581634) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(581476..581634) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(581492) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(581691..581823) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(581734) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(581824..582033) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(581824..582033) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(582066..582085) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582077) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(582116..582931) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(582116..582931) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 582758..582767 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582780..582799 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 582780 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(582944..583933) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(582944..583933) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(583798..583816) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583806) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(583832..583837) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(583955..583970) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583976) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(583982..583991) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(584031..585572) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(584031..585572) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(584044) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(585603..585622) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(585617) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(585636..585645) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(585724..587133) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(585724..587133) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(585738) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(587171..587458) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(587171..587458) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(587174..587193) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(587188) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 587464..587471 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 587487..587506 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 587488 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 587531..588403 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 587531..588403 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 588368 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(588643) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 588697..588716 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 588707 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 588753..589715 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 588753..589715 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 589715..590911 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 589715..590911 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 590933..593146 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 590933..593146 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 593141..593148 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 593163..593182 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 593179..593308 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 593179 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 593309..594850 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 593309..594850 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 594836 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 594957..594961 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 594977..594996 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 594987 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 594994..595096 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 594994..595096 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 595122 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 595231..596553 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 595231..596553 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 596531 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 596574 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 596603..596612 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 596623..596763 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 596623 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 596625..596640 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 596764..597567 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 596764..597567 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 597552 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 597635..597642 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597656..597675 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 597662..597725 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 597662 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 597726..597893 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 597726..597893 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 597900 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 597944..597950 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597965..597983 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 597968..598054 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 597968 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 598033..598040 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598054..598073 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598056 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 598107..598661 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 598107..598661 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 598661..598858 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 598661..598858 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 598848 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 598904..598911 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598926..598945 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598928 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 598938..599040 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 598938..599040 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 599041..599180 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 599181..599669 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 599181..599669 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 599662..600804 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 599662..600804 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 600801..602096 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 600801..602096 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(601106..601125) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(601127) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(601140..601147) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 602170..602895 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 602170..602895 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 602888..603142 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 602888..603142 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 603139..603822 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 603139..603822 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 603806..606034 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 603806..606034 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(604054) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 606010..607440 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 606010..607440 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 607441..607541 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 607542..608582 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 607542..608582 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 608579..609166 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 608579..609166 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 608589..608603 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 608598 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(608865..608883) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(608872) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(608899..608904) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 609163..610701 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 609163..610701 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 610717..611985 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 610717..611985 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 611970 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(612025..612444) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(612025..612444) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(612514..612533) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(612523) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 612588..613862 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 612588..613862 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 613811 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(613877..614104) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(613877..614104) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(613888) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(614105..614525) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 614172..614177 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 614188 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 614191..614210 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 614233..615975 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 614233..615975 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(614510..614521) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(614525) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(614535..614541) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 614556 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 615949..615955 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 615967 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 615968..615987 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 616002..616997 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 616002..616997 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 617000..617314 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 617000..617314 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 617177 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 617319 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(617349..618926) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(617349..618926) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(617363) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(618940..618959) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(618959) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(618974..618980) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 619123..619126 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 619140 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 619143..619162 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 619191..619877 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 619191..619877 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 619939..622158 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 619939..622158 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 622182..624188 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 622182..624188 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 624204..625394 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 624204..625394 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(624399..624403) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(624403) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 625431..625450 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 625439..625555 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 625439 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(625503) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 625556..626566 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 625556..626566 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(625573..625673) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(625613) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 626549 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 626593..627397 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(626604..627302) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(626604..627302) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(626625) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(627322..627340) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(627343) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(627356..627361) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(627409..628887) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(627409..628887) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(627423) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(628275) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(628278..628291) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(628888..629018) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(629009..629027) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(629018) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(629042..629048) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 629149..629152 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 629167..629300 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 629167 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 629169..629188 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 629301..629591 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 629301..629591 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 629607..631064 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 629607..631064 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 631078..632508 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 631078..632508 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 632489 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(632523..633392) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(632523..633392) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(632565) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 633182..633187 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 633203..633221 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 633215 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(633393..633467) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 633445..633452 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(633461..633480) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 633467 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 633468..633487 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(633474) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(633495..633502) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 633524..636682 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 633524..636682 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 636669 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 636921..636924 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 636939..636958 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 636947 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 637005..637916 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 637005..637916 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 637917..638171 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 638172..639551 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 638172..639551 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" CDS 639521..639700 /created_by="User" /locus_tag="PG10_rand_003" /modified_by="User" /transl_table=11 /pseudo /translation="MLCVDKIKRINSQKSMLMELLVRARMIFSATASRCRKQPQERKY VNWRHLQCVRRIGAN*" /label="PG10_rand_003" gene 639521..639700 /locus_tag="PG10_rand_003" /created_by="User" /label="PG10_rand_003" S_feature 639552..>639587 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" SCAR join(639587,639594) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_030" N_region 639588..639593 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27_030" CDS 639622..640506 /gene="cypD" /locus_tag="PG10_pseudo_BSU_07250" /old_locus_tag="BSU_07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /modified_by="User" /translation="MQEAATRAQIRELASFTVCPPHRRELEELSAEGVYQEQILKKRI SMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQASITVGVVRGPAWSG RGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMVGPGTGVAPFRGFL QARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTVHTAFSRKEGMPKT YVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQAVHGTGEQEAQNW LRHLQDTGMYAKDVWAGI*" /label="PG10_pseudo_BSU_07250" gene 639622..640506 /gene="cypD" /locus_tag="PG10_pseudo_BSU_07250" /old_locus_tag="BSU_07250" /modified_by="User" /label="PG10_pseudo_BSU_07250" downshifts 640493 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 640556..640561 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 640577..640595 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 640598 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 640626..640629 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 640646..640665 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 640647..640952 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 640647 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 640953..642872 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 640953..642872 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 642871 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 642960..642969 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 642979..643107 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 642979 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 642983..643002 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(643033) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 643108..643872 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 643108..643872 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 643879..644847 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 643879..644847 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 644871..645782 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 644871..645782 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 645660..645669 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 645682..645701 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 645685 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 645811..646989 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 645811..646989 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 646530..646536 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646551..646570 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 646565 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 646990..647925 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 646990..647925 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 647797 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 647907 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(647948) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(647956..649185) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(647956..649185) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(649214..649233) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(649232) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(649249..649256) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(649296..650003) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(649296..650003) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(649325) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(650026..650045) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(650049) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(650095..651480) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(650095..651480) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(650117) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(651529..651548) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(651546) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(651563..651570) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 651648..651655 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 651663 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 651669..651687 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 651730..653187 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 651730..653187 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(652523..652542) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(652537) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(652555..652564) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 653201..654061 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 653201..654061 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 654045 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 654129..654136 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 654150..654169 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 654155 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 654196..656085 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 654196..656085 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 656069 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 656149..656168 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 656157 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 656208..656654 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 656208..656654 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(656210) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(656294..656297) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(656299) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(656315..656316) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 656641 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 656717..656724 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 656738..656757 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 656750 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 656779..657201 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 656779..657201 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 657037 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 657267..658457 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 657267..658457 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(658521) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 658748..658903 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 658748..658903 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(659023..660579) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(659023..660579) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(659047) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 660409..660415 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660430..660441 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 660447 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(660629..660648) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(660633) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(660664..660668) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 660689..660692 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660708..660727 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 660711 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 660752..661882 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 660752..661882 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 661865 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 661950..662396 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 661950..662396 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(662449..663468) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(662449..663468) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(662459) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(663489..663508) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(663493) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(663495..663949) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(663521..663528) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 663587..663594 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 663608..663627 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 663615..664712 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 663615 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(663950..665170) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(663950..665170) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(665207..665226) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(665214) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665242..665249) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 665268..665275 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 665287..665462 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 665287 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 665290..665309 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 665419 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 665506..666969 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 665506..666969 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(665871..667541) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 666970..667463 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 667451..667456 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 667465..670730 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 667465 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 667472..667490 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(667542..668342) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(667542..668342) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(668355..669356) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(668355..669356) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(668942..668961) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(668954) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(668976..668983) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(669353..670354) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(669353..670354) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(670424..670443) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(670426..671373) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(670426..671373) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(670445) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(670445) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 670700..670705 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 670721..670739 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 670732..671357 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 670732 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 671353..671372 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 671359..671890 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 671359 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(671415..671434) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(671422) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(671448..671455) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(671482..671850) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(671482..671850) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(671851..671963) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(671952..671971) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(671963) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(671983..671990) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 672031..672037 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 672051..672069 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 672051 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 672094..672441 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 672094..672441 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(672095) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 672437 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 672482..672562 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 672563..672582 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 672564 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 672632..673894 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 672632..673894 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 673889 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 673947..673950 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 673965..673984 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 673973 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 674021..675457 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 674021..675457 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 675449 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 675548..675567 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 675559 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 675584..677212 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 675584..677212 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 677184..677864 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 677184..677864 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 677867..678826 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 677867..678826 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 678795 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 678918..678925 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 678938..678957 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 678949..679021 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 678949 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 679022..680323 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 679022..680323 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 680320..680326 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 680340..680351 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 680341 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 680379..681173 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 680379..681173 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 681149 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 681228..681231 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 681246..681265 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 681259 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 681292..682383 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 681292..682383 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(682374..682649) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(682374..682649) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 682384..682715 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(682663..682682) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(682677) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(682697..682704) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 682716..683381 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 682716..683381 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(683422..683559) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(683422..683559) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(683436) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(683560..683690) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(683676..683694) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 683686..683691 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(683690) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 683701..684765 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 683702 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 683707..683725 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(683710..683715) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(683716..683871) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(683716..683871) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(683872..683977) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(683978..684292) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(683978..684292) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(684293..684373) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(684374..685123) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(684374..685123) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(685152..685171) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(685165) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(685167..686303) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(685183..685191) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 685234..685235 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 685255..685274 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 685258 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 685295..686653 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 685295..686653 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(686289..686308) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(686303) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(686322..686331) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 686539 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 686649 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(686686..688635) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(686686..688635) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(686703) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 687745..687751 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 687767..687785 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 687771..688735 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 687771 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(688636..688710) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(688687..688706) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(688710) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(688712..689234) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(688722..688726) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 688736..688873 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 688736..688873 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 688851 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 688852..688871 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 688892..689284 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 688892..689284 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(689232..689250) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(689247) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(689266..689271) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 689353..689359 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 689374..689392 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 689374 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 689409..690824 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 689409..690824 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(689410) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(689436..689536) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(689476) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(690821..691897) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(690821..691897) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 690825..694191 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(691921..692121) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(691921..692121) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(692137..693291) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(692137..693291) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(693272..694813) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(693272..694813) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(694863..694874) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(694866) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(694888..694894) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 694923..694930 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 694945..694964 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 694952 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(694998) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 695006..696418 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 695006..696418 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(695024..695124) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(695064) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 696489..698174 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 696489..698174 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(696795..696810) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(696802) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(696823..696832) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 698147..698151 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 698167..698186 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 698170 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 698195..698911 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 698195..698911 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 698904 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 698986..698989 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 699005..699024 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 699014 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 699051..699716 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 699051..699716 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 699697 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(699753..704141) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(699753..704141) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(699772) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(704174..704193) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(704191) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(704208..704211) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 704318..704324 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 704338..704356 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 704341 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 704384..704902 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 704384..704902 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 704888 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(704932) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 704933..706583 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(704942..706132) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(704942..706132) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(706133..706224) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(706225..706440) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(706225..706440) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(706284) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(706472..706491) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(706486) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(706506..706507) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 706553..706560 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706575..706594 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706585 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 706643..707113 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 706643..707113 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 707131..707451 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 707131..707451 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 707475..708302 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 707475..708302 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 708281..708287 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 708302..708313 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 708320..708476 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 708320 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(708352) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 708451 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(708501..709676) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(708501..709676) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(708506) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 709113..709119 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 709135..709153 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 709139..709792 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 709139 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(709701..709720) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(709716) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(709734..709741) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 709782..709787 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 709794 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 709802..709820 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 709844..710899 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 709844..710899 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 710913..710919 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 710934..710945 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 710938 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 710970..711764 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 710970..711764 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 711752 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(711803..712645) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(711803..712645) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(711805) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(712646..713767) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(712646..713767) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(713808..713827) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(713826) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(713843..713847) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 713855..713862 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 713876..713895 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 713886 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 713912..714097 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 713912..714097 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 714076 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 714140..714146 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 714152 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 714161..714172 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 714198..714989 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 714198..714989 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 714987 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(715027..715887) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(715027..715887) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(715041) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(715907..715926) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(715921) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(715942..715945) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(715986..716945) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(715986..716945) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(716009) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(716956..716975) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(716959) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(716991..716994) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 717006..717010 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 717024..717043 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 717033 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 717064..717927 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 717064..717927 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 717928..718040 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 718041..719441 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 718041..719441 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 719453 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 719747..719754 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 719770..719789 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 719776 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 719783..720066 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 720067..720333 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 720067..720333 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(720281..720300) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(720299) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(720315..720318) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 720334..720815 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 720786..720789 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 720806..720825 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 720817..721064 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 720817 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 721065..722042 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 721065..722042 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 722043..722135 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 722092 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 722176..722182 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 722194..722213 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 722203 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 722238..722690 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 722238..722690 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 722720..723409 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 722720..723409 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 723414 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 723586..723604 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 723593 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 723641..724642 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 723641..724642 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 724646..725674 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 724646..725674 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 725688..726884 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 725688..726884 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(725689) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 726905..728281 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 726905..728281 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 728275 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 728328..728335 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 728348..728367 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 728356 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 728397..730214 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 728397..730214 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" SCAR join(730225,730232) /created_by="User" /modified_by="User" /label="IIG_Bs27_033" N_region 730226..730231 /note="EcoRI site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs27_033" promotor_-35 730269..730276 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 730290..730309 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 730298 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 730355..732925 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 730355..732925 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 732896 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(732943..733920) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(732943..733920) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(732954) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 733935..733942 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(733947..733966) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 733957..733976 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 733959..734050 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 733959 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(733964) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(733981..733988) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 734051..735052 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 734051..735052 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 735049..736080 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 735049..736080 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 736061 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 736131..736133 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736149..736168 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 736152 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 736195..737076 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 736195..737076 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 737087..737094 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737110..737129 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737119 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 737164..737748 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 737164..737748 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 737735 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(737787..737978) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(737787..737978) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(737805) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(738010) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(738013..738024) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(738039..738045) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(738045..738155) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(738045..738155) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(738184..738195) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(738186) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(738210..738216) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(738210..739121) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(738210..739121) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 739007..739010 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 739027..739046 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 739037..739209 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 739037 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(739143..739161) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(739157) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(739175..739181) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 739210..740004 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 739210..740004 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 740006..740320 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 740006..740320 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(740228..740496) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 740310 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 740394..740399 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 740415..740434 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 740420 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 740463..741656 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 740463..741656 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 741657..741891 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(741689..741841) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(741689..741841) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(741706) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 741870..741877 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 741891..741910 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 741893..741965 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 741893 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(741900..741911) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(741910) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(741926..741932) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 741966..742235 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 741966..742235 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 742224 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 742313..742319 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 742334 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 742335..742353 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 742380..742898 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 742380..742898 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 742899..742966 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 742934..742943 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 742955..742970 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 742968 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 742983..743315 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 742983..743315 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 743302..744162 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 743302..744162 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 744160 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 744220..744226 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 744240..744251 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 744248..744312 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 744248 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(744270..744289) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(744279) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 744295..744301 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(744303..744304) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 744314..744394 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 744314 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 744316..744334 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 744395..745384 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 744395..745384 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(744544) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(744549..744553) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(744570..744574) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 745385..745455 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 745456..748041 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 745456..748041 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 748010 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(748034..749017) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(748034..749017) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(748068) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 748491..748500 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 748513..748532 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 748517 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(749018..749165) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 749122..749126 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 749142..749161 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 749149 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 749155..749232 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(749163..749182) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(749165) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(749197..749204) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 749233..750342 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 749233..750342 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 750179..750183 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750199..750218 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 750211 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 750343..750655 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(750350..750574) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(750350..750574) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(750604..750615) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(750606) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(750629..750635) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 750656..751408 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 750656..751408 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 751425..751431 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 751446..751457 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 751447 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(751454..751468) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(751475) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(751477..751481) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 751477..751731 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 751477..751731 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 751729 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(751754) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 751820..752164 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 751820..752164 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 751827..751835 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 751846..751864 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 751848 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 752147 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 752203..752210 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 752224..752243 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 752233..752307 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 752233 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 752308..752838 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 752308..752838 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 752829 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 752926..754668 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 752926..754668 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 754655 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(754745..755806) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(754745..755806) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(754756) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(755807..755897) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(755895..755914) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(755904) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(755929..755936) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(756026..757315) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(756026..757315) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(756029) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(757343..757362) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(757362) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(757364..758075) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(757374..757379) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 757408..757415 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 757429..757448 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 757429 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 757468..757941 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 757468..757941 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 757978..757985 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 758000..758019 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 758006 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 758064..758501 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 758064..758501 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 758483 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(758536..758889) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(758536..758889) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 758549 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(758559) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 758885..758889 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 758897..758911 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(758901..758920) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 758901..758992 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 758901 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(758911) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 758969..758972 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 758987..759006 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 758994..759096 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 758994 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 759097..759981 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 759097..759981 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 759964..759971 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 759985..760004 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 760000..760272 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 760000 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(760033) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 760273..761827 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 760273..761827 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 761995..764922 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 761995..764922 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 764923..765008 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 764984..764991 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765005..765024 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 765010 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 765034..765149 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 765034..765149 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 765159..765233 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 765159..765233 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 765239..765330 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 765239..765330 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 765326 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 765365..765436 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 765365..765436 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 765446..765521 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 765446..765521 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 765531..765607 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 765531..765607 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 765619..765695 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 765619..765695 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 765708..765783 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 765708..765783 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 765789..765861 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 765789..765861 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 765884..765968 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 765884..765968 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 765974..766047 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 765974..766047 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 766072..766147 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 766072..766147 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 766157..766228 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 766157..766228 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 766278..766352 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 766278..766352 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 766358..766428 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 766358..766428 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 766436..766524 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 766436..766524 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 766525..766601 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 766558 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 766603..766771 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 766728..766735 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 766734 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 766749..766768 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 766773 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 766790..766871 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 766790..766871 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(766807..766824) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(766810) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(766845..766850) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(766880) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(766950..767726) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(766950..767726) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(766964) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(767753..767768) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(767775) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(767781..767790) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 767810..767816 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 767831..767842 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 767834 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 767868..768071 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 767868..768071 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 768054 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(768130) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(768156..768428) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(768156..768428) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(768387..768405) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768394) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 768409..768416 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(768422..768427) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768429..768448 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 768437 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 768470..769162 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 768470..769162 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 769191..769195 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(769194..769213) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(769206) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 769209..769228 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(769228..769235) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 769232..769339 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 769232..769339 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 769239 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 769370 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 769472..771244 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 769472..771244 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 771220 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 771265..772190 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(771282..772637) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(771282..772637) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(772665..772684) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(772682) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(772698..772707) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 772755..772761 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 772776..772795 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 772804 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 772888..773085 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 772888..773085 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(773112..774563) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(773112..774563) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(773122) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 774540..774546 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 774561..774580 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 774564 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(774581..774600) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 774586..774915 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(774600) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(774614..774621) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(774659..774677) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(774684) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 774872 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 774971..775738 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 774971..775738 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 775756..776754 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 775756..776754 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 776751..777581 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 776751..777581 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 777604..778734 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 777604..778734 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 778761..778780 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 778767 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 778838..779374 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 778838..779374 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 779375..779445 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 779415..779422 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 779436..779455 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 779447 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 779486..779755 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 779486..779755 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 779558..779562 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 779585..779601 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 779601 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 779742 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(779773..780246) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(779773..780246) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(779809) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(780248..780448) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(780248..780448) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(780477..780496) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(780491) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(780509..780516) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 780572..780577 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 780591..780610 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 780591 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 780642..780715 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 780642..780715 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 780716..780898 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(780806..781429) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(780806..781429) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(780821) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 780855 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 780900..781511 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(781453..781472) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(781474) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(781486..781493) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 781512..782672 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 781512..782672 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 782681 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 782698..782710 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 782703 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 782739..783674 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 782739..783674 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(782757) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 783658..783661 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 783676 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 783677..783696 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 783712..784194 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 783712..784194 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 784177 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 784244..784960 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 784244..784960 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 784264..784271 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 784286..784305 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 784287 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 784951..785664 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 784951..785664 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 785676..786383 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 785676..786383 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 786267 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 786311 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 786377 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(786410..786585) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(786453) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(786577..786596) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(786585) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(786611..786618) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 786650..786655 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786671..786689 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786671 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 786733..788628 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 786733..788628 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 787175..787275 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 787235 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 787301 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 788621 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 788685..788690 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 788706..788724 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 788709..788807 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 788709 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 788808..789986 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 788808..789986 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 789006..789009 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 789024..789043 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 789028 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(789269) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 789965 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 790073..790080 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790095..790114 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790095 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 790146..790610 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 790146..790610 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 790435..790441 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790456..790474 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790469 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 790619..790625 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790639..790650 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790645 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 790646..791311 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 790646..791311 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 791352..792950 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 791352..792950 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 792973..793503 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 792973..793503 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 793516..793890 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 793516..793890 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 793879 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 793890..794045 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 793890..794045 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 793980..793986 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 794001..794020 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 794011 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 794050..794811 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 794050..794811 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(794363..794381) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(794377) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(794397..794402) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 794814..795179 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 794814..795179 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 795181..795879 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 795181..795879 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 795896..796813 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 795896..796813 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 796806..797747 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 796806..797747 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 797729 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(797839..798042) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(797839..798042) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(797853) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(798043..798170) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 798130..798141 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 798147 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(798159..798178) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(798170) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(798172..799310) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(798192..798197) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 798337..798344 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 798359..798377 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 798366 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 798367..798477 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 798478..799308 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 798478..799308 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 799267 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(799311..800390) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(799311..800390) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(800400..800419) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(800421) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(800435..800439) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 800497..800504 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 800518..800537 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 800524 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 800563..801954 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 800563..801954 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(801590..801993) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 801933 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(801994..802449) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(801994..802449) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(802464..802482) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(802492) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(802497..802503) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 802541..802547 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 802561..802572 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 802565 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 802599..803168 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 802599..803168 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 802795..802801 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 802812 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 802815..802826 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 803143 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 803211..803220 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 803234..803253 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 803244 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 803289..804257 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 803289..804257 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 804133 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(804189..804842) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(804189..804842) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(804206) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(804873..804884) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(804875) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(804899..804905) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 804914..804922 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 804925..808578 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 804925..808578 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 804933..804951 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 804948 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 808575..809171 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 808575..809171 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 809150 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(809201..810109) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(809201..810109) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 810165..810173 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(810166..810177) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(810172) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(810174..810660) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 810184 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 810187..810206 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(810191..810197) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 810220..810615 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 810220..810615 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(810646..810665) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(810660) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 810700..810706 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 810715 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 810720..810731 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(810730..810744) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(810744) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(810752..810756) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 810752..811174 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 810752..811174 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(811078..811178) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(811118) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 811152 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(811184) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 811224..811231 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811245..811264 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811253 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 811301..811963 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 811301..811963 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 811979..813520 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 811979..813520 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 813503 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 813604..813795 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 813604..813795 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 813826..813833 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 813848..813867 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 813859..813940 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 813859 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 813941..815293 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 813941..815293 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 815321..815899 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 815321..815899 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 815894..815901 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 815916..815935 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 815927 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 815942 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 815987..816077 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 816078..816902 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 816078..816902 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 816921..818411 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 816921..818411 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 817722..817728 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 817743..817762 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 817753 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 818412..818500 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 818457 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 818463..818563 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 818523 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 818552..820219 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 818552..820219 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 819981..819986 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 820001..820019 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 820010 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 820064..820070 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 820085 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 820086..820104 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 820187 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 820232..820305 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 820287..820294 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 820307 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 820308..820327 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 820351..822096 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 820351..822096 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 822085 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 822130..822199 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 822201..822220 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 822201 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 822245..823384 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 822245..823384 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 823381..824025 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 823381..824025 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 824022..824546 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 824022..824546 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 824511 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(824561..824803) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(824561..824803) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(824582) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(824839..824850) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(824850) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(824864..824871) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 824938..824944 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824958..824969 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824968 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 825004..825327 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 825004..825327 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 825328..827194 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(825369..826835) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(825369..826835) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(825381) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(825468) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(826875..826893) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826887) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(826907..826914) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(826988..827428) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(826988..827428) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(827018) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 827416..827422 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827436..827447 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 827438..827548 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 827438 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(827450..827469) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(827466) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(827481..827487) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 827507 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(827535..829193) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(827535..829193) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(827540) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(829084..829102) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(829104) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(829116..829122) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 829165..829170 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 829186..829204 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 829199 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 829224..830630 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 829224..830630 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 830610 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(830660..832045) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(830660..832045) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(830686) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(832072) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(832074..833605) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(832082..832093) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 832201..832208 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832221..832240 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 832227..832514 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 832227 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 832477..832480 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832495..832514 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 832516 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 832575..833579 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 832575..833579 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 833441 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 833571 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(833605) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(833612..833627) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 833617 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(833639..833648) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(833650..834525) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(833650..834525) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 834578..834579 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(834591..834610) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 834596..834615 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(834597) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 834606 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(834625..834630) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 834634..835734 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 834634..835734 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 835745..835751 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835766..835784 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835771 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 835808..836677 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 835808..836677 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 836685 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 836762..836765 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 836777 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 836780..836799 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 836825..836844 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 836830..836926 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 836830 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 836927..838324 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 836927..838324 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 838304 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 838385..838389 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 838405..838424 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 838412 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 838442..839797 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 838442..839797 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 839778 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(839832..841241) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(839832..841241) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 841290..841293 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 841308..841327 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 841310 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(841312..841331) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(841324) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(841347..841351) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 841351..841779 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 841351..841779 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 841758 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(841810..842100) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(841810..842100) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(841834) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(842088..843164) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(842088..843164) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(843154..843645) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(843154..843645) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(843646..843748) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(843737..843756) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(843748) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(843770..843773) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 843786..843792 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 843803 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 843807..843825 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(843836) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 843842..844837 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 843842..844837 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 844816 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 844899..844902 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 844917..844936 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 844922 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 844972..845571 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 844972..845571 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 845586 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 845631..847585 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(845640..846974) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(845640..846974) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(845659) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(847035..847466) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(847035..847466) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(847478..847497) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(847488) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(847512..847518) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(847514..847614) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 847549..847556 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(847554) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 847570..847589 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 847587 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 847623..848804 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 847623..848804 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 848789 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 848834..848972 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 848968..848987 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 848974..849130 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 848974 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 849131..850516 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 849131..850516 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 850406 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 850492 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(850530..850886) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(850530..850886) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(850883..851278) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(850883..851278) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(851265..851996) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(851265..851996) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(852021..852040) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(852042) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 852089..852097 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 852106 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 852111..852126 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 852120..852193 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 852180..852181 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 852195 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 852197..852216 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 852230..852337 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 852230..852337 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 852338..852391 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 852362 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 852442..852461 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 852448 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 852486..853601 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 852486..853601 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 853581 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 853638..853657 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 853638 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 853671..854414 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 853671..854414 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 854386 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(854438..855286) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(854438..855286) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(854462) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 855282..855287 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(855287..855386) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 855303..855321 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 855305 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 855310..855505 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(855375..855394) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(855389) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(855409..855412) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 855504..855523 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 855507..855570 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 855507 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 855571..856419 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 855571..856419 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 856410 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(856462..857823) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(856462..857823) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(856486) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(857824..857894) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(857867..857886) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(857894) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(857950..858450) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(857950..858450) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(857982) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(858472..858490) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(858492) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(858505..858511) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 858529..858536 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 858544..858613 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 858545 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 858551..858570 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 858614..858775 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 858614..858775 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 858705 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 858776..858894 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 858895..860652 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 858895..860652 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 860649..862670 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 860649..862670 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 862658 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(862719..863339) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(862719..863339) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(862734) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 863324..863424 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(863353..863372) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(863368) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(863378..863503) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(863378..863503) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 863384 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(863387..863390) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(863517..863536) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(863526) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(863550..863559) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 863582 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(863608..863811) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(863608..863811) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(863613) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(863812..863922) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 863852..863952 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 863912 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(863928) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(863932..863943) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(863958..863964) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(864020..864238) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(864020..864238) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(864054) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(864279..864298) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(864296) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(864312..864319) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(864388..865749) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(864388..865749) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(864406) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(864450) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(865739..866830) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(865739..866830) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(866154..866168) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(866166) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(866182..866190) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(866831..866936) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(866920..866938) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(866940) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(866954..866959) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 867002..867009 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 867024..867043 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 867035 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 867097..868230 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 867097..868230 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 868231..868322 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 868323..868676 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 868323..868676 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 868664 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(868720..869793) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(868720..869793) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(868827) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(869815..869834) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(869827) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(869848..869855) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 869930..869937 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 869950 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 869952..869971 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 869961..870114 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 870071 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 870116..870199 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 870156 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 870212..870217 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 870233..870251 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 870242 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 870279..871145 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 870279..871145 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 871127 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 871190..871193 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 871208..871227 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 871216 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 871257..872762 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 871257..872762 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 872732 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(872780..873997) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(872780..873997) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(872786) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(874004..874501) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(874004..874501) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(874565..874903) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(874565..874903) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(874915..874934) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(874939) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(874948..874955) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 874975..874982 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 874997..875016 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875007 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 875068..875835 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 875068..875835 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 875836 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(875856..876041) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(875856..876041) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(876077..876095) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(876088) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(876106..876114) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 876115..876118 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 876133..876152 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 876143 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 876168..877064 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 876168..877064 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 877057..878316 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 877057..878316 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 878300 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 878364..878371 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 878383..878402 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 878388 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 878423..879649 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 878423..879649 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(879124) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 879654..882545 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 879654..882545 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 880935..880940 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 880956..880974 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 880962 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 882553..882558 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 882573..882592 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 882588 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 882619..883563 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 882619..883563 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 883541 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 883622..883627 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 883643..883661 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 883646 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 883688..883900 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 883688..883900 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 883893 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(883931) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(883941..884819) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(883941..884819) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(884129) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(884857..884876) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(884881) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(884890..884897) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 884917..884926 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 884938 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 884939..884958 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(884975..884989) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(884976) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 884979..885065 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 884979..885065 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(884998..885002) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 885066..885317 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 885190..885276 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 885190..885276 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 885274 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(885286..885548) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 885319..885802 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(885329) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(885541..885560) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(885548) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(885550..885618) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(885574..885579) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(885619..886137) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(885619..886137) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 885924..885932 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885944..885962 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885957 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(886168..886187) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(886186) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(886203..886209) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 886286..886289 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 886304..886323 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 886309 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 886345..886686 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 886345..886686 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(886540..886682) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(886583) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(886683..887294) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(886683..887294) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 886687..887452 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(886759) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 887290..887294 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887302..887315 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887314 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(887319..887338) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(887342) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(887353..887356) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 887409 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(887472..887828) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(887472..887828) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(887476) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 887905..887910 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(887911..887930) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(887925) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 887926..887944 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887926 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(887927..888190) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 887958..888149 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 887958..888149 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 888150..889585 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(888223..888741) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(888223..888741) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(888235) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(888742..888829) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(888821..888840) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(888829) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(888854..888861) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(888866..889945) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(888866..889945) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(889984..890003) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(889995) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(889997..890078) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(890092..890529) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(890092..890529) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(890123) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(890562..890581) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(890576) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 890579 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(890595..890602) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(890601..890897) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(890644) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(890895..890906) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(890901) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(890921..890927) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 890957..890964 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890978..890997 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890987 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 891017..891760 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 891017..891760 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 891753..892979 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 891753..892979 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(892312..892330) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(892327) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(892346..892351) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 892999..893709 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 892999..893709 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 893673 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(893727..894917) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(893727..894917) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(893737) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(893802) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(894941..894960) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(894962) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(894974..894979) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(894990..896381) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(894990..896381) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(896392..896411) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(896397) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(896424..896433) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(896447..896761) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(896447..896761) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(896806..897306) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(896806..897306) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(896833) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(897319..897338) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 897321..897325 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(897340) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 897341..897360 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 897342 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(897355..897356) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 897373..897379 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 897394..897405 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 897399 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 897428..899572 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 897428..899572 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(897472..897483) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897475) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(897497..897503) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 899609..899615 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899629..899648 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 899639 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 899694..900755 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 899694..900755 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 900827..901759 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 900827..901759 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 901774..903186 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 901774..903186 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 901777 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 903163 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 903247..903254 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 903268..903287 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 903273 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 903332..903907 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 903332..903907 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 903651..903654 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 903669 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 903671..903690 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 903908..903977 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 903978..906305 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 903978..906305 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 906287 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(906347..907324) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(906347..907324) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(906360) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(907338..907357) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(907356) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(907371..907377) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 907383..907391 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 907402..907420 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 907409 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 907451..908227 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 907451..908227 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(907943..908564) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 908228..908599 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(908542..908561) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(908563) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(908575..908584) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 908577..908584 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 908599..908618 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 908601 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 908640..909680 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 908640..909680 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 909693..910100 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 909693..910100 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 910071 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(910137..911426) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(910137..911426) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(910167) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(911427..911527) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(911526..911545) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(911527) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(911529..911665) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(911560..911566) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(911697..911837) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(911697..911837) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(911710) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(911856..911875) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(911875) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(911888..911895) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 911919..911925 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 911939..911958 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 911942 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 911989..912723 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 911989..912723 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 912736..913731 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 912736..913731 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 913796..914440 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 913796..914440 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 914428 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 914468..914471 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 914486..914505 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 914493 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 914557..916098 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 914557..916098 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 916078 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(916154) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 916176..916177 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_031" CDS 916216..916929 /gene="yhfQ" /locus_tag="PG10_pseudo_BSU_10330" /old_locus_tag="BSU_10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /modified_by="User" /translation="MLKKIDGYTSVGTRSQPSMEKIASLKPDLIIADTTRHKKVYDQL KKIAPTIALNNLNADYQDTIDASLTIAKAVGKEKEMEKKLTAHEEKLSETKQKISANS QSVLLIGNTNDTIMARDENFFTSRLLTQVGYRYAISTSGNSDSSNGGDSVNMKMTLEQ LLKTDPDVIILMTGKTDDLDADGKRPIEKNVLWKKLKAVKNGHVYHVDRAVWSLRRSV DGANAILDELQKEMPAAKK*" /label="PG10_pseudo_BSU_10330" gene 916216..916929 /gene="yhfQ" /locus_tag="PG10_pseudo_BSU_10330" /old_locus_tag="BSU_10330" /modified_by="User" /label="PG10_pseudo_BSU_10330" downshifts 916908 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(916961..917542) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(916961..917542) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(916984) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(917566..917585) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(917578) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(917601..917604) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(917613..918707) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(917613..918707) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(918704..920143) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(918704..920143) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(920150..920710) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(920150..920710) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(920160..920179) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(920174) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(920735..920754) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(920749) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(920769..920776) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(920845..922143) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(920845..922143) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(920856) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(922197..922215) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(922200) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(922229..922235) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(922282..923811) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(922282..923811) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(923838..923856) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(923848) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 923867..923872 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(923871..923876) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 923884 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 923888..923906 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 923923..924780 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 923923..924780 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 924762 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(924808..925041) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(924808..925041) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(924841) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(925058..925077) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 925061..925062 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 925061 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 925065..925080 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(925080) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(925082..925937) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(925092..925099) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 925264..925271 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 925283..925302 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 925289 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 925334..925912 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 925334..925912 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 925913..926058 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(925959..926858) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(925959..926858) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(925982) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 926045..926048 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 926060 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 926066..926070 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 926104 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 926149..927015 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(926885..926903) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(926902) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(926918..926924) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 926992..926999 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 927014..927033 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 927017 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 927075..927344 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 927075..927344 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 927336 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(927384) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(927387..928856) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(927387..928856) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(928853..929053) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(928853..929053) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(929054..929172) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(929155..929174) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(929172) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(929187..929194) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(929260) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(929261..929623) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(929261..929623) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 929461..929466 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 929482..929500 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 929483 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 929492..929731 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(929653..929672) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(929671) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(929687..929694) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 929713..929720 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 929733 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 929734..929753 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 929775..930398 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 929775..930398 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 930400..930906 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 930400..930906 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 930899 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 930957..930964 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 930978..930997 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 930987..931086 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 930987 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 931087..932586 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 931087..932586 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 932594..932601 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 932613 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 932615..932634 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 932663..933190 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 932663..933190 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 933152 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(933204..>933224) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" SCAR join(933224,933240) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" N_region 933225..933239 /note="inserted sequence possibly derived from two restrictions with NotI and SacI" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" S_feature <933240..933526 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(<933240..933361) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(933246) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(933362..934516) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(933362..934516) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(934517..934588) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(934571..934590) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(934587) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(934604..934609) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(934623..935828) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(934623..935828) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 935849..935868 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 935854 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 935942..937669 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 935942..937669 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 937255..937262 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 937277..937296 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 937284 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(937699..938025) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(937699..938025) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(938143..938580) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(938143..938580) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(938152) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(938611..938630) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938631) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(938643..938652) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 938700..938707 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938721..938740 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 938733 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 938764..942264 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 938764..942264 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 942251..945949 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 942251..945949 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 945950..946020 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 946021..947196 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 946021..947196 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 947193..950585 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 947193..950585 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 949840..949846 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 949861..949872 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 949868 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(949937..950910) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 950599..950901 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 950599..950901 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 950881 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(950955) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" SCAR 950959..950960 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_007" downshifts 950979 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(951018..951605) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(951018..951605) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(951620..951639) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951639) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(951655..951657) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 951660..951666 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 951678 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 951681..951699 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 951684..951750 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 951751..953595 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 951751..953595 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 953596..953663 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 953620 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(953725..954204) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(953725..954204) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(954224) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(954228..954246) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(954257..954265) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 954396..954400 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 954413 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 954415..954434 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 954436..955260 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 954436..955260 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 954648..954654 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 954669..954687 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 954676 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 955270..956720 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(955290..956657) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(955290..956657) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 956689..956696 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 956710..956729 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 956722 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 956781..957644 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 956781..957644 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 957662..958675 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 957662..958675 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 958658 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 958727..958734 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 958749..958768 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 958768..958883 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 958768 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 958884..959912 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 958884..959912 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 959934 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(959963..960472) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(959963..960472) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(959982) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(960485..960503) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(960501) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(960515..960523) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(960522..961184) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(960522..961184) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 961203..961209 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 961223..961242 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 961232 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 961251..962705 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 961251..962705 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(962560..962712) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(962595) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(962713..963351) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(962713..963351) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(963352..963486) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 963400..963405 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963421..963439 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 963422 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 963432..963556 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(963472..963491) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963486) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963506..963513) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 963557..964363 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 963557..964363 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 964356 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(964391..964990) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(964391..964990) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(964410) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(964987..966156) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(964987..966156) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(966157..966268) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(966269..966979) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(966269..966979) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(967023..967042) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(967045) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(967055..967064) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 967094..967103 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 967117..967136 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 967128 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 967164..967850 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 967164..967850 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 967847..968605 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 967847..968605 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 968602 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(968650..969279) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(968650..969279) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(969313..969331) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(969330) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(969346..969351) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(969375..970490) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(969375..970490) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(969404) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(970499..971767) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(970499..971767) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(971793..971804) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(971802) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(971818..971824) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(971879..972727) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(971879..972727) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(971890) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(972732..973181) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(972732..973181) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(973202..973221) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973216) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(973237..973238) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(973271..975109) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(973271..975109) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(973298) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(975191) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(975199..975316) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(975199..975316) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(975368..975387) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(975382) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(975402..975409) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(975423..975914) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(975423..975914) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 975932..975935 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(975938..975957) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 975950..975969 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 975951 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(975956) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(975972..975979) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 976013..976909 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 976013..976909 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 976896 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(976972) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 976984..976985 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_016" S_feature <976985..977038 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" promotor_-10 complement(<976985..976999) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977003) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 977017..977022 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977037..977055 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977040 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 977077..977919 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 977077..977919 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 977572..977580 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977591..977609 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977591 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 977920..978033 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 978034..978393 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 978034..978393 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 978382 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(978424..978621) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(978424..978621) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(978437) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(978622..978818) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(978818) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(978820..978831) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(978846..978852) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(978878..979690) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(978878..979690) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(979728..979747) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 979748..979755 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(979748) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(979761..979768) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 979767..979786 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 979769 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 979811..980578 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 979811..980578 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 980587..980593 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 980607 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 980608..980627 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 980642..980950 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 980642..980950 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 980935 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 980980..981245 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 981246..982676 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 981246..982676 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 982721..983215 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 982721..983215 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 983179 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 983353..983360 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 983359 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 983374..983393 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 983422..984459 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 983422..984459 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 984479..985699 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 984479..985699 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 985714..986490 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 985714..986490 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 986487..987644 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 986487..987644 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 987715..988770 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 987715..988770 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(988325,988326) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(988604..988623) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(988614) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 988763..991855 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 988763..991855 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 991843..992802 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 991843..992802 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 992765 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(992805..993079) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 992830..992836 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(992838) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 992851..992862 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 992872 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 992888..993067 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 992888..993067 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 993077 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(993113..993298) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(993113..993298) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(993124) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(993327..993346) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(993344) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(993357..993364) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 993399..993405 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 993417..993436 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 993422 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 993479..993488 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 993488 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 993501..993520 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 993547..994281 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 993547..994281 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(994040..994642) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 994262..994267 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 994280 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 994280 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 994283..994301 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 994363..994920 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 994363..994920 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(994622..994641) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(994642) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(994656..994660) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 994927..994934 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 994949..994968 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 994961 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 995011..995964 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 995011..995964 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 995628..995632 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 995648..995667 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 995661 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 995979..996170 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 995979..996170 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 996149 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 996194..996534 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(996200..996439) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(996200..996439) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(996216) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(996452..996471) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(996473) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(996485..996494) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 996500..996507 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 996522..996541 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 996536 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 996604..997542 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 996604..997542 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 996681..996690 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 996699 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 996702..996717 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 997565..998806 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 997565..998806 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(997779..997797) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(997787) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(997813..997818) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 998657 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 998790 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 998831..998840 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 998853..998872 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 998855 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 998867..998875 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 998882..999667 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 998882..999667 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 998887..998905 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 998899 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 999668..999752 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(999684..999702) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999701) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999717..999722) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 999720..999727 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 999742..999761 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 999754..999858 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 999754 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 999859..1000845 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 999859..1000845 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1000842..1001831 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1000842..1001831 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1001837..1001843 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1001842..1001918 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1001842 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1001919..1002410 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1001919..1002410 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1002383..1003549 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1002383..1003549 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1003540 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1003625..1004575 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1003625..1004575 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1004592..1005503 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1004592..1005503 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1005517 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1005562..1005669 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1005642..1005647 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1005663..1005681 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1005671 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1005708..1006460 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1005708..1006460 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1006440 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1006495..1007487) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1006495..1007487) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1006516) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1007546..1007760) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1007546..1007760) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1007594) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1007779..1007798) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1007792) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1008047..1008054 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1008068..1008230 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1008069..1008088 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1008069 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1008231..1009868 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1008231..1009868 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1009762 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1009869..1009975 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1009976..1010911 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1009976..1010911 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1010019..1010038) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1010036) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1010054..1010060) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1010915..1011832 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1010915..1011832 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1011837..1012913 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1011837..1012913 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1012915..1013832 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1012915..1013832 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1013802 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1013882..1013885 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1013898 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1013900..1013919 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1013939..1015156 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1013939..1015156 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1015209..1015218 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1015231..1015246 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1015240..1015319 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1015240 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1015320..1015898 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1015320..1015898 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1015899..1016013 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1015950..1015969) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1015954) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1015983..1015990) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1016016..1016029 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1016016 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1016079..1016474 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1016079..1016474 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1016310..1016410) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1016350) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1016472 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1016517..1017306 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1016517..1017173) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1016517..1017173) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1017203..1017221) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1017218) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1017236..1017241) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1017279..1017286 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1017300..1017319 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1017308..1017449 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1017308 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1017343..1017483 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1017343..1017483 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1017450..1018106 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1017450..1018106 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1018096 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1018101..1018223) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1018101..1018223) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1018141..1018230 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1018209..1018217 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018228..1018246 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1018232..1018296 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1018232 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1018297..1019418 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1018297..1019418 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1019072..1019078 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1019090 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1019093..1019111 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1019304..1019312 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1019324..1019342 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1019331 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1019412..1019418 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019433..1019444 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019442 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1019465..1021477 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1019465..1021477 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1019540..1019547 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1019562..1019581 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1019574 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1021424 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1021478..1021779 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1021515..1021682) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1021515..1021682) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1021528) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1021702..1021720) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1021718) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1021736..1021741) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1021772..1021779 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1021781..1021906 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1021781 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1021787..1021925 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1021787..1021925 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1021794..1021813 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1021863 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1021996..1022895) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1021996..1022895) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1022027) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1022231..1022236 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1022243 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1022252..1022270 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1022259..1024160 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1022892..1023290) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1022892..1023290) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1023291..1023470) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1023462..1023481) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1023470) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1023493..1023500) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1023545..1024090) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1023545..1024090) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1023569) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1024091..1024293) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1024294..1024866) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1024294..1024866) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1024439..1024457) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1024448) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1024470..1024477) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1024895..1024914) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1024912) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1024928..1024931 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1024929..1024936) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1024944 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1024947..1024966 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1024991..1025359 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1024991..1025359 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1025388..1026023 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1025388..1026023 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1026042..1026842 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1026042..1026842 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1026905..1027756 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1026905..1027756 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1027715 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1027769..1028503) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1027769..1028503) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1027791) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1028625..1028629 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1028646..1028665 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1028660 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1028661..1028737 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1028738..1030582 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1028738..1030582 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1029065..1029084) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1029089) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1030584..1030591 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1030605..1030624 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1030611 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1030644..1030752 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1030644..1030752 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1030747 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1030831..1031541 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1030831..1031541 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1031516..1032133 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1031516..1032133 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1032117..1033226 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1032117..1033226 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1033226..1033426 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1033226..1033426 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1033423..1034193 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1033423..1034193 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1034190..1035200 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1034190..1035200 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1035219..1036034 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1035219..1036034 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1036008 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1036081..1036087 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1036100..1036119 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1036110 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1036170..1036946 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1036170..1036946 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1036935 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" SCAR 1036950..1036951 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_009" S_feature <1036951..1038011 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1036955..1039234) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1036955..1039234) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1036973) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1039109..1039283) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1039162..1039170 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1039181..1039199 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1039185..1039320 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1039185 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1039271..1039290) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1039282) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1039298..1039304 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1039306..1039310) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1039319..1039337 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1039322 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1039351..1039605 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1039351..1039605 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1039581 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1039671) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1039678..1040100) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1039678..1040100) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1040104..1040619) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1040104..1040619) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1040656..1041378) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1040656..1041378) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1041417..1041436) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1041438) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1041487..1041494 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1041509..1041528 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1041513 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1041546..1041666 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1041546..1041666 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1041671 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1041734..1042855 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1041734..1042855 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1042848..1044020 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1042848..1044020 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1044003 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1044037..1044055 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1044047 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1044048..1045577 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1044053..1044598) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1044053..1044598) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1044074) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1044668..1045858) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1044668..1045858) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1045884..1045903) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045888) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045918..1045925) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1045952..1045959 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1045963 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1045973..1045992 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1046031..1046103 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1046031..1046103 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1046045..1046062) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1046059) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1046083..1046089) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1046093 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1046118..1046853) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1046138..1047786 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1046147) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1046855..1046943) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1046898) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1046944..1048173) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1046944..1048173) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1047066) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1047743 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1048174..1048259) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1048214..1048221 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1048236..1048255 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1048245..1048264) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1048249 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1048263) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1048277..1048283) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1048299..1048619 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1048299..1048619 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1048629 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1048674..1048771 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1048772..1048903 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1048772..1048903 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1048919..1049092 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1048919..1049092 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1049129..1049590 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1049129..1049590 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1049561..1049568 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1049583..1049602 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1049591..1049831 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1049591 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1049804..1049811 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1049825..1049843 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1049833 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1049856..1050359 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1049856..1050359 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1050371..1050655 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1050371..1050655 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1050625 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1050657) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1050668..1050671) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1050816..1051343 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1050816..1051343 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1051490..1051495 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1051508..1051527 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1051511 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1051517..1051834 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1051517..1051834 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1051835..1052070 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1052071..1052826 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1052071..1052826 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1052827..1052914 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1052871 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1052914..1052974) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1052945) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1052975..1053322) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1052975..1053322) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1053354..1053372) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053367) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1053369..1053825) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1053383..1053391) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1053785..1053803 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1053797 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1053803..1053822) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053825) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1053836..1053843) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1053873..1055819 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1053873..1055819 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1055795 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1055849..1055850 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1055850..1055948 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1055923..1055929 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1055944..1055963 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1055950..1056018 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1055950 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1056019..1056501 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1056019..1056501 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1056481 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1056547..1057053) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1056547..1057053) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1056571) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1057078..1057097) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1057084) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1057086..1057271) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1057272..1057667) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1057272..1057667) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1057690..1057708) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1057703) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1057705..1058405) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1057723..1057728) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1057811..1057818 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1057832..1057851 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1057843 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1057896..1058375 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1057896..1058375 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1058374 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1058415..1058609) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1058415..1058609) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1058450) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1058623..1058638) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1058639) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1058650..1058659) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1058775..1059104) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1058775..1059104) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1059141..1059160) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1059154) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1059156..1059723) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1059175..1059180) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1059208..1059212 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1059228..1059247 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1059232..1059733 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1059232 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1059724..1060713) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1059724..1060713) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1060714..1060733) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1060717) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1060747..1060752) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1060836..1061084) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1060836..1061084) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1060846) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1061080..1061084 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1061093..1061107 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1061102 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1061109..1061128) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1061118) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1061142..1061151) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1061199..1061206 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1061213..1061232) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1061220..1061239 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1061222) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1061233 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1061234..1061337 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1061246..1061253) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1061338..1062741 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1061338..1062741 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1062730 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1062781..1063254) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1062781..1063254) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1062785) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1063276..1063294) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1063294) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1063309..1063314) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1063379..1063546) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1063379..1063546) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1063382) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1063558..1063576) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1063567) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1063589..1063596) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1063673..1064572 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1063673..1064572 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1064581..1064979) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1064581..1064979) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1064611) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1065008..1065027) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065027) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1065042..1065049) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1065080..1065655) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1065080..1065655) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1065095) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1065674..1065692) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065689) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1065706..1065712) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1065730..1065736 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1065751..1065769 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1065752 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1065801..1068758 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1065801..1068758 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1068751..1069311 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1068751..1069311 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1069304 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1069349..1069467 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1069445..1069448 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1069464..1069483 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1069469 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1069508..1070149 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1069508..1070149 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1069517) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1070122 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1070228..1070854 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1070228..1070854 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1070856 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1070859) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1070885..1071163) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1070885..1071163) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1070903) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1071192..1071203) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1071205..1071211) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1071211) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1071213..1071629) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1071381 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1071382..1071401 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1071399..1071553 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1071554..1072744 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1071554..1072744 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1071627..1071646) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1071629) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1071660..1071669) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1072767..1073945 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1072767..1073945 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1073986..1074174) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1073986..1074174) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1074002) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1074200..1074219) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1074203) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1074233..1074239) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1074261..1074268 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1074283..1074302 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1074294 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1074309..1074328) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1074313) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1074343..1074350) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1074348..1075160 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1074348..1075160 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1075139 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1075206..1075958) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1075206..1075958) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1075215) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1075958..1076710) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1075958..1076710) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1076830..1077804) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1076830..1077804) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1076865) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1077825..1077844) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1077851) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1077853..1080359) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1077859..1077866) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1077887..1077893 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1077908..1077926 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1077911 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1077936..1078433 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1077936..1078433 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1078434..1078547 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1078527..1078531 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1078547..1078566 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1078549..1078821 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1078549 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1078822..1079244 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1078822..1079244 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1079284..1080462 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1079284..1080462 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1080293..1080393 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1080351..1080369) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1080353 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1080359) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1080381..1080389) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1080461 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1080570..1080577 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1080592..1080611 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1080617 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1080660..1082081 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1080660..1082081 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1082149..1083528 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1082149..1083528 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1082668..1082687) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1082673) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1082701..1082708) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1083553 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1083563..1083570 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1083565..1083632 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1083633..1084646 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1083633..1084646 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1084652..1085671 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1084652..1085671 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1085696..1086775 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1085696..1086775 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1086772..1087608 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1086772..1087608 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1087656..1088924 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1087656..1088924 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1088868..1088871 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1088887..1088891 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1088889 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1088957..1088976 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1088957 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1089012..1090013 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1089012..1090013 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1089695..1089795) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1089735) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1089989 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1090090..1091532 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1090090..1091532 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1091529..1093022 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1091529..1093022 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1093061..1093825) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1093061..1093825) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1093080) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1093593,1093595) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1093852,1093859) /created_by="User" /modified_by="User" /label="TF8A" N_region 1093853..1093858 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1093861..1094181 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1093861..1094181 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1094190 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1094199..1094402) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1094218..1094355) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1094218..1094355) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1094242) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1094441..1094611) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1094441..1094611) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1094447) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1094611..1095357) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1094611..1095357) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1095192..1095211) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1095209) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1095227..1095234) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1095383..1095401) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1095396) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1095417..1095422) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1095467..1096468) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1095467..1096468) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1095496) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1096481..1097098) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1096481..1097098) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1097134..1097153) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1097136) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1097138..1097235) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1097169..1097173) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1097215..1097234) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1097235) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1097249..1097256) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1097280..1097299) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1097292) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1097374..1098690) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1097374..1098690) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1097389) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1098737..1098756) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1098753) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1098771..1098774) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1098973..1098980 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1098995..1099014 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1099007..1099078 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1099007 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1099079..1100029 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1099079..1100029 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1100017 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1100130..1100276 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1100130..1100276 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1100284..1102434 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1100284..1102434 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1101173..1101273 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1101233 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1101321 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1102446..1103417 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1102446..1103417 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1102774..1103415) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1103460) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1103485..1103851) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1103528) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1103831..1103846) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1103851) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1103858..1103867) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1103935..1105284) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1103935..1105284) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1103949) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1105324..1105331 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1105336..1105355) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1105344 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1105346..1105365 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1105354) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1105356..1105438) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1105366..1105373) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1105395..1105401 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1105416..1105435 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1105419 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1105421..1105440) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1105438) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1105453..1106271 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1105453..1106271 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1105456..1105459) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1106249 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1106328..1106335 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1106350..1106369 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1106354 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1106400..1107224 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1106400..1107224 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1107241..1108167 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1107241..1108167 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1108173..1109135 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1108173..1109135 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1108867..1108872 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1108888..1108906 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1108889 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1109140..1110147 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1109140..1110147 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1110150..1111799 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1110150..1111799 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1111793 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1111887..1112846 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1111887..1112846 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1112843..1113943 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1112843..1113943 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1113940..1114830 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1113940..1114830 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1114843..1115832 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1114843..1115832 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1115126..1115853) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1115822 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1115867..1117035 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1115875..1116924) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1115875..1116924) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1115898) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1116951..1116970) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1116962) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1116985..1116992) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1117014..1117874) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1117014..1117874) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1117899..1117917) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1117916) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1117933..1117939) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1117948..1117955 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1117969..1117988 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1117976 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1118034..1118552 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1118034..1118552 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1118543 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1118617..1118623 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1118635..1118741 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1118635 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1118637..1118648 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1118716..1118719 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118735..1118754 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1118743 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1118791..1119990 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1118791..1119990 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1119979 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1120024..1120395 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1120067..1120291) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1120067..1120291) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1120371..1120377 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1120391..1120402 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1120397 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1120436..1121167 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1120436..1121167 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1121145 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1121206..1121214 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1121225..1121243 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1121233 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1121259..1121786 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1121259..1121786 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1121776..1122294 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1121776..1122294 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1122288..1122295 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1122309..1122328 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1122312 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1122327..1122438 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1122327..1122438 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1122401 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1122516..1122854 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1122516..1122854 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1122854..1123171 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1122854..1123171 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1123171..1123174 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1123190..1123209 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1123202 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1123242..1124144 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1123242..1124144 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1124135 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1124191..1124197 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1124203 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1124211..1124230 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1124232..1124442 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1124232..1124442 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1124400 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1124495..1125592 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1124495..1125592 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1124682..1124684 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1124686..1124690 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1124686 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1125604..1126851 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1125604..1126851 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1126842 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1126913..1126920 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1126935..1126954 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1126944 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1126977..1127402 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1126977..1127402 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1127391 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1127433..1127876) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1127433..1127876) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1127467) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1127903..1127922) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1127909) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1127937..1127940) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1127958..1127964 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1127978..1127996 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1127984 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1128019..1128429 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1128019..1128429 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1128407 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1128456..1128626 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1128456..1128626 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1128627..1129304 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1128676..1129146) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1128676..1129146) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1128700) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1129168..1129187) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1129184) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1129186..1129293) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1129203..1129206) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1129262 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1129319..1131607) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1129319..1131607) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1129338) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1131608..1131670) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1131630..1131730) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1131670) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1131735..1131890) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1131735..1131890) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1131736) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1131923..1131942) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1131935) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1131937..1132022) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1131958..1131965) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1132023..1132982) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1132023..1132982) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1132983..1133034) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1133027..1133046) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1133039) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1133060..1133066) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1133151..1133154 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1133167 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1133170..1133189 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1133205..1134038 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1133205..1134038 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1134014 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1134069..1134833) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1134069..1134833) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1134090) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1134808..1136451) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1134808..1136451) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1136438..1137037) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1136438..1137037) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1137039..1137641) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1137039..1137641) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1137719) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1137738..1137850) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1137738..1137850) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1137851..1137854 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1137865..1137884) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1137870..1137889 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1137881 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1137886) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1137899..1137906) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1137952..1138638 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1137952..1138638 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1138642..1140006 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1138642..1140006 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1140003..1140683 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1140003..1140683 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1140712..1140717 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1140733..1140751 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1140736 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1140775..1141287 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1140775..1141287 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1141273 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1141318..1141324 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1141338..1141349 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1141339 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1141370..1141507 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1141370..1141507 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1141480 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1141566..1141573 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1141587..1141606 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1141589..1141908 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1141589 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1141621..1141774 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1141621..1141774 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1141886..1141895 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1141908..1141927 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1141910..1142011 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1141910 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1142012..1143367 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1142012..1143367 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1143358 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1143410..1143742) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1143410..1143742) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1143758..1143777) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1143768) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1143770..1144158) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1143793..1143798) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1143830..1143930 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1143890 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1143937..1144092 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1143937..1144092 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1144101..1144108 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1144115..1144132 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1144132 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1144143..1144162) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1144158) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1144176..1144182) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1144180..1144362 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1144180..1144362 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1144330 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1144387..1144395 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1144406..1144424 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1144412..1144494 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1144412 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1144495..1144959 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1144495..1144959 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1144944 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1144974..1146095) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1144974..1146095) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1145383..1145391 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1145405..1145424 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1145408..1146186 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1145408 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1146124..1146135) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1146144) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1146150..1146156) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1146187..1146738 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1146187..1146738 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1146706 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1146766..1147578) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1146766..1147578) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1147538..1147557) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1147552) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1147571..1147576) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1147679..1147685 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1147696..1147770 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1147696 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1147699..1147710 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1147771..1149465 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1147771..1149465 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1149478..1150491 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1149478..1150491 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1150476 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1150517..1152352) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1150517..1152352) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1150566) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1152356..1153291) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1152356..1153291) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1153262..1153273) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153272) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1153288..1153294) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1153328..1155730) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1153328..1155730) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1153360) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1155578..1155780) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1155769..1155787) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155780) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155801..1155808) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1155847..1155854 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1155868..1155887 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1155880 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1155911..1156576 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1155911..1156576 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1156445..1156464) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1156462) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1156478..1156487) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1156571..1156578 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1156593..1156612 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1156606 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1156632..1156765 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1156632..1156765 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1156653..1157627 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1156653..1157627 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1156716 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1157615 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1157737..1157745 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1157759..1157767 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1157769 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1157772..1157858 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1157831..1157838 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1157852..1157871 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1157860 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1157891..1158646 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1157891..1158646 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1158643..1159788 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1158643..1159788 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1159789..1160948 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1159799..1159993) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1159799..1159993) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1159806) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1160036..1160047) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1160046) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1160062..1160068) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1160124..1160825) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1160124..1160825) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1160158) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1160826..1160906) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1160898..1160917) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1160906) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1160922..1160929 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1160931..1160938) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1160943..1160962 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1160950 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1160996..1161892 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1160996..1161892 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1161886 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1161997..1162001 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1162017..1162036 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1162021 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1162066..1163415 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1162066..1163415 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1163403 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1163464..1163470 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1163484..1163495 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1163492..1163559 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1163492 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1163560..1163715 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1163560..1163715 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1163718..1163894 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1163718..1163894 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1163784..1163884 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1163844 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1163890 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1163937..1164959) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1163937..1164959) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1163960) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1165004..1165023) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1165020) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1165035..1165041) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1165148..1165156 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1165164 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1165167..1165185 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1165212..1167428 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1165212..1167428 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1167203..1168143) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1167281..1167288 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1167303..1167322 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1167305 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1167425..1167922 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1167425..1167922 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1167923..1168162 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1168012..1168137 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1168012..1168137 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1168130 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1168171..1169232) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1168171..1169232) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1168188) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1169240..1170433) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1169240..1170433) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1169300 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1170520) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1170526..1170682) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1170526..1170682) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1170717..1170736) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1170718) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1170752..1170759) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1170762..1170765 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1170766..1171545) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1170766..1171545) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1170781..1170800 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1170790 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1171238..1171245 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1171258..1171277 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1171273 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1171280..1171597 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1171567..1171574 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1171575..1171594) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1171589..1171608 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1171589) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1171599 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1171610..1171617) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1171640..1172836 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1171640..1172836 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1172818..1172825 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1172840..1172859 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1172859 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1172875..1172975 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1172875..1172975 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1172974 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1173060..1174277 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1173060..1174277 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1174274..1174981 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1174274..1174981 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1174939..1175568 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1174939..1175568 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1175583..1176119 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1175583..1176119 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1175966..1176159) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1176119 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1176160..1176480) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1176160..1176480) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1176218) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1176481..1176570) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1176506..1176512 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1176527..1176545 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1176537 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1176538..1176622 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1176552..1176571) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1176569) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1176586..1176589) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1176596..1176603 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1176618..1176637 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1176624..1176682 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1176624 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1176680) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1176683..1176940 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1176683..1176940 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1176934 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1177026..1177457 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1177026..1177457 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" downshifts complement(1177497) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" SCAR join(1177532,1177642) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_027" N_region 1177533..1177641 /modified_by="User" /label="IIG_Bs27_027" CDS complement(1177652..1179751) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1177652..1179751) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1177674) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1179752..1180002) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1179962..1180062) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1180002) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1180038..1180043 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1180053 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1180059..1180077 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1180116..1181159 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1180116..1181159 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1181160..1181251 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1181228..1181232 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1181249..1181268 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1181253 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1181298..1181342 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1181298..1181342 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1181319 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1181364..1181471 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1181472..1182131 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1181472..1182131 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1182124..1182573 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1182124..1182573 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1182566..1183297 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1182566..1183297 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1183315..1183812 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1183315..1183812 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1183813..1184089 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1184047 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1184057) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1184126..1184370) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1184167) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1184371..1184727) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1184371..1184727) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1184758..1184777) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1184775) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1184812..1184830 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1184817 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1184896..1185642 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1184896..1185642 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1185697 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1186045..1186053 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1186067..1186086 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1186071 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1186123..1187322 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1186123..1187322 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1186205..1186211 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1186226..1186244 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1186232 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1187291..1187293 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1187313..1187331 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1187325 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1187338..1187565 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1187338..1187565 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1187415..1187434) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1187423) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1187566..1187661 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1187662..1188360 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1187662..1188360 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1188313..1189139) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1188341..1188592 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1188341..1188592 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1188842..1188857 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1188865..1189076 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1188865 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1189041 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1189128..1189147) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189150) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1189163..1189170) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1189215..1189222 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1189237..1189256 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1189239 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1189275..1189565 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1189275..1189565 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1189602..1189685) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1189645) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1189686..1189871) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1189686..1189871) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1189904..1189923) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189915) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1189917..1190261) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1189937..1189944) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1189970..1189975 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1189991..1190010 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1189998 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1190037..1190231 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1190037..1190231 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1190207 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1190252..1190270) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1190268) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1190287..1190292) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1190530..1191156 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1190530..1191156 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1191087 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1191213..1191218 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1191225 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1191234..1191252 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1191274..1192611 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1191274..1192611 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1192662..1193159 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1192662..1193159 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1193008..1193014 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1193023 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1193029..1193047 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1193133 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1193254..1193260 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1193271..1193290 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1193283 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1193287..1193394 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1193395..1195308 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1193395..1195308 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1193544..1193563) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1193561) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1193576..1193585) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1193712..1193731) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1193737) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1193745..1193751) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1195289 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1195365) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1195576..1195595) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1195585) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1195609..1195616) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1195660..1195679 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1195670 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1195715..1196806 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1195715..1196806 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1196455 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1196785 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1196819..1197037) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1196830..1197087 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1197024..1197043) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1197037) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1197059..1197066) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1197088..1198053 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1197088..1198053 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1198071..1198078 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1198093..1198112 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1198105 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1198116..1198982 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1198116..1198982 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1198837..1198841 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1198858..1198877 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1198866 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1198984 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1199029..1199180 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1199029..1199180 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1199029..1199180 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1199158..1199164 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199178..1199189 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1199182 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1199211..1201310 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1199211..1201310 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1201328..1201332 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1201348..1201367 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201359 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1201408..1201674 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1201408..1201674 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1201674..1203386 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1201674..1203386 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1203373 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1203426..1203432 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1203447..1203458 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1203450 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1203477..1203716 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1203477..1203716 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1203497..1204836) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1203794..1204822 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1203794..1204822 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1204792 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1204837..1205517) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1204837..1205517) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1205527..1205546) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1205550) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1205561..1205568) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1205602..1205609 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1205623..1205641 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1205629 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1205652..1207619 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1205652..1207619 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1206092..1206107) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1206104) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1207590 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1207663..1207665 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1207681..1207700 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1207691 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1207733) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1207757..1208623 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1207757..1208623 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1208603 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1208662..1209435) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1208662..1209435) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1208679) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1209467..1209486) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1209477) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1209710..1209729 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1209723 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1209725..1209828 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1209772..1211886 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1209772..1211886 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1211065..1211083) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1211077) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1211099..1211104) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1211867 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1211959..1211967 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1211979..1211997 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1211991 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1212050..1213870 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1212050..1213870 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1213881..1215062) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1213881..1215062) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1213915) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1215090..1215109) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1215106) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1215138..1215156) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1215150) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1215152..1215220) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1215171..1215176) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1215214..1215233) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1215220) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1215264..1215425) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1215264..1215425) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1215448..1215467) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1215461) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1215481..1215488) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1215562..1215569 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1215581 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1215582..1215600 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1215629..1216540 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1215629..1216540 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1215634) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1216083..1216091 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1216105..1216122 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1216108 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1216525 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1216584..1217048) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1216584..1217048) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1216602) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1217078..1217097) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1217088) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1217112..1217119) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1217174..1218466) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1217174..1218466) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1217196) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1218490..1218509) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1218494) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1218525..1218529) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1218542..1219036) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1218542..1219036) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1219052..1219071) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1219068) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1219085..1219094) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1219093..1219953) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1219093..1219953) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1219974..1219993) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1219987) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1220024..1220031 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1220047..1220066 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1220060 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1220096..1220860 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1220096..1220860 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1220861..1221009 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1220990..1221008 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1221011..1221160 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1221011 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1221058) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1221161..1222891 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1221161..1222891 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1222957..1223475 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1222957..1223475 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1223473 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1223518..1223523 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1223536..1223555 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1223539 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1223571..1224119 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1223571..1224119 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1224120..1224271 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1224272..1225495 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1224272..1225495 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1225458..1225476) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1225468) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1225474 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1225491..1225496) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1225544..1225551 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1225563..1225664 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1225563 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1225566..1225585 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1225581..1225664 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1225581..1225664 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1225621 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1225675..1225680 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1225695..1225979 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1225695 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1225697..1225715 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1225956..1225962 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1225976..1225987 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1225981..1226068 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1225981 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1226057..1226076 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1226070 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1226141..1226380 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1226141..1226380 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1226381..1226489 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1226490..1227008 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1226490..1227008 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1227045..1227052 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1227066..1227085 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1227080 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1227142..1227339 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1227142..1227339 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1227335 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1227380..1227476 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1227477..1227920 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1227477..1227920 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1227921..1228028 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1227996..1228001 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1228016..1228035 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1228030 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1228069..1228950 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1228069..1228950 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1228929 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1228985..1228992 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1229007..1229026 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1229012 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1229062..1229538 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1229062..1229538 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1229528..1230421 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1229528..1230421 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1230437..1230892 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1230437..1230892 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1230708..1230727) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1230721) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1230741..1230749) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1230886 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1230931..1230938 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1230952..1230971 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1230953 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1230997..1231707 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1230997..1231707 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1231006) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1231116..1231120) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1231116) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1231777..1232901 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1231777..1232901 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1232913..1232919 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1232933..1232944 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1232935 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1232939..1232953) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1232963..1232967) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1232963..1233208 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1232963..1233208 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1232964) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1233196 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1233241..1234191 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1233245..1234048) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1233245..1234048) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1233257) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1234099..1234118) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1234108) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1234132..1234139) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1234164..1234171 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1234186..1234205 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1234193..1234284 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1234193 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1234285..1234827 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1234285..1234827 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1234899..1235345 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1234899..1235345 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1235353 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1235738..1235745 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1235758 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1235760..1235779 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1235811..1236386 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1235811..1236386 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1236364 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1236427..1237392) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1236427..1237392) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1236440) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1236736..1236737 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1236755..1236774 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1236761..1237485 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1236761 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1237413..1237431) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1237434) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1237446..1237451) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1237472..1237478 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1237488 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1237492..1237511 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1237529..1238128 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1237529..1238128 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1238179..1239198 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1238179..1239198 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1239216..1240508 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1239216..1240508 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1240469..1240990 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1240469..1240990 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1240990..1241463 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1240990..1241463 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1241456..1241689 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1241456..1241689 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1241668 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1241734..1241739 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1241756..1241774 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1241764 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1241776..1241862 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1241852..1241855 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1241864 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1241870..1241889 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1241913..1243670 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1241913..1243670 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1243682..1245496 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1243682..1245496 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1244119..1244138) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1244129) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1244153..1244160) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1245547..1245556 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1245568..1245583 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1245572 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1245606..1246301 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1245606..1246301 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1246306..1247439 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1246306..1247439 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1247440..1248132 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1247440..1248132 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1248129..1249322 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1248129..1249322 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1249300 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1249371..1249377 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1249391..1249402 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1249399 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1249444..1249451 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1249466..1249485 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1249471..1249562 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1249471 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1249526..1249533 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1249547..1249566 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1249564 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1249602..1250357 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1249602..1250357 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1249750) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1249752..1249754) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1250354..1251265 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1250354..1251265 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1251280..1253187 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1251280..1253187 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1253172 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1253256..1253263 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1253274..1253293 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1253277 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1253332..1253913 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1253332..1253913 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1253898 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1253942 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1253947..1254216) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1253947..1254216) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1253952) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1254217..1254282) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1254263..1254282) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1254282) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1254335..1254342 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1254353..1254372 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1254357 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1254397..1256019 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1254397..1256019 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1256007 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1256076..1256987 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1256076..1256987 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1256992 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1257021..1258253) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1257021..1258253) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1257032) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1258271..1258290) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1258295) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1258305..1258310) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1258363..1258497) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1258363..1258497) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1258374) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1258519..1258537) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1258530) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1258532..1258597) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1258553..1258558) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1258598..1259605) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1258598..1259605) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1259651) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1259652..1259660) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1259674..1259682) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1259792..1259801 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1259813 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1259814..1259829 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1259816..1259888 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1259889..1260167 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1259889..1260167 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1260165 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1260199..1261828) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1260210..1260314 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1260222) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1260296..1260303 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1260315..1260334 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1260316 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1260357..1261643 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1260357..1261643 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1261659..1262492 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1261659..1262492 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1261825..1261843) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1261840) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1261859..1261864) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1262555..1263220 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1262555..1263220 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1263204 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1263311..1263317 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1263332..1263351) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1263332..1263351 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1263344 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1263346) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1263375..1265108 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1263375..1265108 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1264503..1265107) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1265097 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1265142..1266809) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1265142..1266809) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1265152) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1266815..1267024) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1266815..1267024) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1267061..1267080) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1267083) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1267085..1267262) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1267095..1267098) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1267263) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1267265..1267276) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1267290..1267296) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1267335..1267342 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1267356..1267375 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1267372 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1267410..1268183 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1267410..1268183 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1268154 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1268219..1268773) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1268219..1268773) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1268230) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1268795..1268814) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1268805) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1268829..1268836) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1268858 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1268882) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1268883..1269041) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1268883..1269041) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1268948..1269091) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1268948..1269091) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1269037..1269041 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1269042..1269110) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1269051..1269065 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1269078 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1269094..1269113) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1269123) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1269126..1269135) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1269197..1269204 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1269218..1269237 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1269222 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1269255..1269926 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1269255..1269926 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1269594..1269603 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1269616..1269634 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1269628 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1269873 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1270101..1270106 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1270123..1270142 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1270124..1270349 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1270124 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1270128..1270147) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1270144) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1270248..1270256) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270254) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1270270..1270278) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1270350..1271465 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1270350..1271465 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1271469..1272446 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1271469..1272446 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1272447..1272560 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1272481..1272500) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1272498) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1272515..1272518) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1272561..1273889 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1272561..1273889 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1272705..1272712 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1272727..1272746 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1272730 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1273894..1275306 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1273894..1275306 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1275303 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1275351..1275725) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1275351..1275725) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1275399) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1275756..1275775) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1275766) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1275929..1275934 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1275950..1275968 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1275960 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1275964..1276073 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1275996) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1276057..1276064 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1276075 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1276079..1276098 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1276094..1276304 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1276094..1276304 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1276144..1276263 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1276144..1276263 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1276150) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1276250 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1276295..>1277894 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1276303..1277775) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1276303..1277775) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1276321) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1277776..1277871) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1277854..1277873) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1277871) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1277878..1277881 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1277888..>1277894) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 1277894..1277895 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_019" CDS 1278092..1280032 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1278092..1280032 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1280022..1280291 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1280022..1280291 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1280257..1280261 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1280275..1280294 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1280288 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1280291..1280812 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1280291..1280812 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1280809..1281102 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1280809..1281102 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1281142..1281753) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1281142..1281753) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1281156) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1281785..1281804) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1281794) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1281819..1281822) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1282009) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1282026..1282214) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1282026..1282214) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1282080) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1282236..1282255) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1282253) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1282268..1282275) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1282281..1282300 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1282288 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1282327..1284165 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1282327..1284165 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1284222..1284539 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1284222..1284539 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1284513 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1284588) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1284595..1284804) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1284595..1284804) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1284818..1284837) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1284833) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1284887..1285516) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1284887..1285516) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1284918) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1285418..1285436) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1285424) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1285448..1285456) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1285551..1285562) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1285556) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1285568..1285573 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1285577..1285583) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285589..1285607 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1285589 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1285590..1285670 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1285671..1286999 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1285671..1286999 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1286855..1287002) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1286898) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1287000..1287590 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1287003..1287488) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1287003..1287488) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1287500..1287519) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287528) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1287534..1287541) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1287591..1288520 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1287591..1288520 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1288105..1288124 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1288114 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1288544..1288547 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1288562..1288581 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1288570 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1288618..1288899 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1288618..1288899 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1288888 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1288962..1288965 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1288978..1289104 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1288978 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1288983..1288989 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1289105..1290316 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1289105..1290316 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1290326..1290330 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1290345..1290364 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1290364 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1290391..1293837 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1290391..1293837 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1293403..1293421) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1293423) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1293437..1293442) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1293817 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1293862 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1293894) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1293906 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1294240..1295160) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1294240..1295160) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1294246) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1295200..1295219) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1295215) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1295233..1295240) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1295295..1295302 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1295316..1295335 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1295317..1295422 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1295317 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1295424..1295514 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1295424 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1295430..1295433 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1295448..1295464 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1295515..1296432 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1295515..1296432 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1296461 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1296480 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1296481..1296486 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1296540..1296545 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1296560..1296578 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1296568..1296671 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1296568 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1296672..1297742 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1296672..1297742 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1297775..1299643 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1297775..1299643 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1299643..1300266 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1299643..1300266 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1300269..1300601 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1300269..1300601 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1300628..1301521 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1300628..1301521 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1301496 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1301553..1301915) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1301553..1301915) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1301572) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1301908..1301912 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1301921..1301934 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1301939..1301958) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1301943..1302054 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1301943 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1301951) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1301973..1301980) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1302055..1302501 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1302055..1302501 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1302087..1302094 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1302106..1302125 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1302111 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1302510..1302517 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1302531..1302550 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1302542 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1302585..1303625 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1302585..1303625 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1303548..1303566) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1303553) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1303582..1303587) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1303605 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1303789..1303798 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1303812..1303831 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1303826 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1303857..1304255 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1303857..1304255 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1303861) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1304271..1304510 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1304271..1304510 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1304489 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1304577..1304584 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1304595..1304614 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1304600 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1304626..1305075 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1304626..1305075 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1305061 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1305130..1305402 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1305130..1305402 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1305207..1305430) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1305405..1305525 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1305405..1305525 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1305432..1305555) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1305475) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1305526..1305631 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1305556..1305568) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1305563) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1305583..1305589) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1305612..1305616 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1305632..1305651 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1305633..1305724 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1305633 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1305725..1306279 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1305725..1306279 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1306284..1306769 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1306284..1306769 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1306736 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1306780..1308006) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1306780..1308006) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1306781..1308055 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1308007..1308108) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1308030..1308037 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308049..1308068 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1308057..1308186 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1308057 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1308103..1308121) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1308118) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1308138..1308143) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1308187..1308969 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1308187..1308969 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1308749..1308755 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308769..1308780 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1308780 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1308971..1309996 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1308971..1309996 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1309880 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1310013..1311260) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1310013..1311260) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1310040) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1311177..1311183 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1311197..1311208 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1311201 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1311257..1311442) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1311257..1311442) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1311275..1311279 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1311295..1311314 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1311304..1311439 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1311304 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1311333..1311352) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1311343) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1311366..1311373) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1311410..1311417 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1311431..1311450 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1311441 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1311470..1311988 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1311470..1311988 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1312010..1312189 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1312010..1312189 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1312169 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1312212) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1312216..1312219) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1312270..1312275 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1312291..1312309 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1312292 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1312335..1312916 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1312335..1312916 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1312917 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1312973..1313455) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1312973..1313455) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1312992) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1313445 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1313478..1313497) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313497) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1313511..1313518) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1313555..1313561 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1313573..1313592 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1313575 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1313615..1314511 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1313615..1314511 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1314582..1316201 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1314582..1316201 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1316173 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1316235..1316238 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1316253..1316326 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1316253..1316272 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1316253 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1316310) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1316327..1316758 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1316327..1316758 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1316828..1317763 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1316828..1317763 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1317430..1318882) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1317803..1318156 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1317803..1318156 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1318153..1320303 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1318153..1320303 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1318863..1318881) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1318882) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1318896..1318902) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1320286 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1320358..1320363 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1320379..1320397 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1320379 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1320420..1322360 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1320420..1322360 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1322156..1322162 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1322177..1322185 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1322183 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1322333 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1322378..1322445 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1322415..1322419 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1322435..1322454 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1322447..1322535 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1322447 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1322536..1324020 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1322536..1324020 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1324021..1324131 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1324132..1325106 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1324132..1325106 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1325107..1326462 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1325107..1326462 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1326286..1326291 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1326307..1326325 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1326317 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1326523..1327623 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1326523..1327623 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1327624..1327745 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1327746..1328837 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1327746..1328837 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1328226..1328235 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1328248..1328263 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1328253 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1328259..1328359 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1328319 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1328869..1329780 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1328869..1329780 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1329798 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1329910..1330701 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1329910..1330701 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1330698..1331393 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1330698..1331393 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1331416..1332123 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1331416..1332123 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1332141..1332506 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1332141..1332506 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1332358..1332361 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1332377..1332396 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1332393 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1332507..1332679 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1332680..1334002 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1332680..1334002 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1332887) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1332891..1332895) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1332910..1332914) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1334038..1335186 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1334038..1335186 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1335160 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1335281,1335288) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1335282..1335287 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1335288..1335333 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1335298..1335305 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1335318..1335337 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1335335 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1335392..1336186 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1335392..1336186 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1336104..1336107 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1336122..1336141 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1336130 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1336199..1336300 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1336199..1336300 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1336287 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1336388..1337668 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1336388..1337668 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1337609..1337625) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1337614) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1337689..1337694 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1337710..1337728 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1337714 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1337751..1337996 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1337751..1337996 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1337912..1337920 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1337931..1337949 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1337939 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1337997..1338107 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1338099..1338118 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1338109 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1338159..1338995 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1338159..1338995 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1339002..1339694 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1339002..1339694 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1339691..1340146 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1339691..1340146 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1340153..1340425 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1340153..1340425 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1340414 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1340486..1341259 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1340486..1341259 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1340975..1340982 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1340996..1341014 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1341019 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1341260..1341352 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1341353..1341847 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1341353..1341847 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1341860..1341867 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1341881..1341900 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1341888 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1341910..1342136 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1341910..1342136 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1342103 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1342189..1344954 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1342189..1344954 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1344945 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1345000) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1345035..1345041 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1345056..1345067 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1345056 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1345099..1345473 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1345099..1345473 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1345505..1345509 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1345524 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1345525..1345544 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1345576..1346040 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1345576..1346040 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1346042..1346953 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1346042..1346953 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1346948..1346955 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1346970..1346989 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1346984 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1346993..1347109 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1346993..1347109 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1347136..1347681 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1347136..1347681 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1347330) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1347672 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1347685..1347802 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1347685..1347802 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1347855..1349162 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1347855..1349162 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1349163..1349277 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1349163..1349277 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1349308..1350222 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1349308..1350222 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1350206..1351492 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1350206..1351492 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1351489..1352583 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1351489..1352583 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1352568..1355783 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1352568..1355783 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1355780..1356550 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1355780..1356550 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1356550..1357485 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1356550..1357485 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1357454..1358173 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1357454..1358173 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1358152..1358802 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1358152..1358802 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1358804 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1358849..1358921 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1358901..1358908 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1358922..1358941 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1358923 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1358947..1359052 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1358947..1359052 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1359053..1359213 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1359214..1359915 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1359214..1359915 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1359927..1360991 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1359927..1360991 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1361040..1362188 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1361040..1362188 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1361129) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1361141..1361145) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1361163..1361164) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1362201..1362794 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1362201..1362794 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1362795..1362892 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1362893..1363666 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1362893..1363666 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1363571..1363578 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1363593..1363612 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1363594 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1363669..1364454 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1363669..1364454 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1364435..1364923 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1364435..1364923 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1364903 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1364950) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1364963..1366681) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1364963..1366681) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1366703..1366722) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1366717..1366722 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1366717) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1366735..1366740) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1366738..1366756 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1366742 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1366797..1369469 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1366797..1369469 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1368202..1368221) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1368213) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1368236..1368243) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1369475..1369494 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1369478..1369551 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1369478 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1369552..1370427 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1369552..1370427 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1370504..1370773 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1370504..1370773 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1370584..1370588) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1370589) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1370781..1371395 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1370781..1371395 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1371399..1371602 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1371399..1371602 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1371591 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1371683..1372903 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1371683..1372903 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1372742..1373317) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1372900..1375317 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1372900..1375317 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1373313..1373331) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1373317) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1373345..1373351) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1375168..1375172 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1375188..1375207 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1375199 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1375344..1375826 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1375344..1375826 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1375831..1376784 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1375831..1376784 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1376771..1378114 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1376771..1378114 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1378118..1379209 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1378118..1379209 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1379216..1379980 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1379216..1379980 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1379269 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1379974..1381920 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1379974..1381920 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1381829..1381835 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1381849..1381867 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1381865 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1381935..1382831 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1381935..1382831 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1382836..1383489 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1382836..1383489 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1383487..1383496 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1383510..1383529 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1383515 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1383562..1384206 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1383562..1384206 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1383967..1383973 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1383984 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1383988..1384006 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1384097..1384102 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1384118..1384136 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1384131 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1384207..1384277 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1384278..1384358 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1384278..1384358 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1384373 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1384418..1384790 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1384431..1384619) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1384431..1384619) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1384447) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1384493) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1384620..1384712) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1384694..1384713) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1384712) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1384729..1384732) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1384763..1384770 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1384785..1384803 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1384792 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1384831..1384834 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1384849..1384868 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1384857 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1384896..1385258 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1384896..1385258 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1385109) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1385274..1386935 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1385274..1386935 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1386936..1387025 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1386998..1387005 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1387019..1387038 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1387027 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1387074..1387736 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1387074..1387736 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1387762..1388664 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1387762..1388664 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1388642..1390690 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1388642..1390690 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1390726..1390733 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1390748..1390767 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1390754 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1390799..1391365 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1390799..1391365 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1391379..1392380 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1391379..1392380 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1392399..1393352 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1392399..1393352 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1393345..1394085 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1393345..1394085 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1394116..1394120 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394136..1394155 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1394141 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1394169..1394402 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1394169..1394402 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1394383 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1394411..1394511 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1394471..1394541 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1394471 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1394542..1395291 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1394542..1395291 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1395263 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1395333..1395339 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1395351..1395370 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1395373 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1395392..1398952 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1395392..1398952 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1398886..1399956) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1398972..1399961 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1398972..1399961 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1399948 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1399998..1400483) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1399998..1400483) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1400001) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1400505..1400523) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1400521) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1400537..1400544) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1400586..1400592 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1400607..1400626 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1400609 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1400660..1400992 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1400660..1400992 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1400663) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1401006..1402346 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1401006..1402346 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1402347..1402451 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1402452..1402724 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1402452..1402724 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1402724..1402969 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1402724..1402969 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1402941 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1402986..1403090 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1403091..1403477 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1403091..1403477 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1403482..1404006 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1403482..1404006 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1404003..1404734 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1404003..1404734 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1404740..1404747 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1404761..1404780 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1404765 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1404813..1404854 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1404813..1404854 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1404874..1405221 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1404874..1405221 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1405223 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1405276..1405282 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1405295..1405363 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1405295 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1405296..1405315 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1405364..1406212 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1405364..1406212 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1406233..1406240 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1406253..1406271 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1406263 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1406283..1407050 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1406283..1407050 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1407082..1408812 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1407082..1408812 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1408319) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1408320..1408339) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1408354..1408361) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1408809..1409090 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1408809..1409090 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1408922 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1409091..1409210 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1409182..1409189 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1409203..1409222 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1409212 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1409263..1410420 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1409263..1410420 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1409335..1409435) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1409375) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1410449..1411351 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1410449..1411351 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1411341 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1411412..1412305 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1411412..1412305 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1412311..1412318 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1412333..1412352 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1412340..1412492 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1412340 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1412493..1414568 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1412493..1414568 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1414538 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1414600..1414605 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1414612 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1414621..1414639 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1414644..1415951 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1414644..1415951 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1415957..1415961 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1415978..1415997 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1415988 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1416019..1416933 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1416019..1416933 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1416058..1416062 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1416075 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1416078..1416097 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1416946..1417491 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1416946..1417491 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1417508..1418911 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1417508..1418911 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1418951..1419730 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1418951..1419730 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1419705 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1419749 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1419850..1419857 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1419870..1419888 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1419881..1420034 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1419881 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1420009..1420016 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1420031..1420050 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1420036 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1420110..1420499 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1420110..1420499 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1420499..1420951 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1420499..1420951 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" SCAR 1420952..1420953 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_004" CDS 1421008..1421772 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1421008..1421772 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1421782..1421788 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1421801..1422304 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1421801..1422304 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1421803..1421814 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1421817 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1422300..1422306 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1422321..1422340 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1422323..1422447 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1422323 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1422448..1423188 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1422448..1423188 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1423170 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1423215..1423289 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1423290..1424171 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1423290..1424171 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1424172..1424316 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1424317..1425039 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1424317..1425039 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1425041..1425598 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1425041..1425598 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1425545) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1425587..1425590 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1425605..1425624 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1425623..1425728 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1425623 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1425729..1426511 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1425729..1426511 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1426515..1427324 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1426515..1427324 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1427305..1427312 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1427327..1427346 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1427328 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1427386..1428537 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1427386..1428537 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1428544..1429812 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1428544..1429812 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1429845..1431539 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1429845..1431539 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1431540..1431647 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1431648..1435961 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1431648..1435961 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1435962..1436026 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1435972..1436189 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1435972..1436189 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1435998..1436004 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1436019..1436030 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1436028..1436095 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1436028 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1436078..1436084 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1436097..1436290 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1436097 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1436098..1436117 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1436291..1436761 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1436291..1436761 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1436612) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1436796..1437911 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1436796..1437911 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1436858..1436958) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1436898) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1437925..1438200 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1437925..1438200 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1438202..1438504 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1438202..1438504 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1438524..1440674 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1438524..1440674 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1440569..1440575 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1440584 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1440590..1440608 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1440671..1440949 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1440671..1440949 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1440966..1441319 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1440966..1441319 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1441310 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1441401..1442330 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1441401..1442330 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1442115..1442122 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1442136..1442155 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1442145 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1442349..1443299 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1442349..1443299 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1443332..1443338 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1443339..1443455 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1443339 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1443353..1443372 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1443456..1443725 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1443456..1443725 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1443708 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1443753..1443838 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1443819..1443822 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1443838..1443857 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1443840 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1443898..1446015 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1443898..1446015 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1445798 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1445999 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1446044..1446132 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1446133..1447092 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1446133..1447092 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1446201..1446209) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1446204) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1446223..1446230) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1446696..1446701 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1446717..1446735 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1446722 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1447132..1448361 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1447132..1448361 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1448350 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1448390..1448395 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1448405 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1448411..1448429 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1448439..1448696 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1448439..1448696 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1448697..1448751 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1448724 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1448793..1448802 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1448812..1448881 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1448812 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1448816..1448835 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1448882..1449775 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1448882..1449775 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1449778..1450380 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1449778..1450380 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1450434..1450453 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1450434..1450505 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1450434 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1450506..1451546 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1450506..1451546 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1451547..1451637 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1451638..1452852 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1451638..1452852 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1452883..1453755 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1452883..1453755 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1453226..1454410) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1453762 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1453855..1453858 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1453872 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1453874..1453893 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1453933..1455600 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1453933..1455600 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1454397..1454415) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1454414) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1454431..1454436) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1455588 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1455655..1455661 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1455675..1455686 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1455676 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1455716..1456453 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1455716..1456453 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1456450..1456662 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1456450..1456662 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1456690..1456709 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1456704 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1456793..1459156 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1456793..1459156 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1459157..1459257 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1459218..1459225 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1459240..1459259 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1459258 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1459300..1460025 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1459300..1460025 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1460012 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1460081..1460087 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1460100 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1460102..1460113 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1460164..1461372 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1460164..1461372 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1461330 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1461441..1461448 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1461461..1461480 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1461483 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1461495..1461498 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1461514..1461526 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1461528 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1461552..1462832 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1461552..1462832 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1462829..1464115 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1462829..1464115 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1463965 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1464116..1464169 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1464170..1464898 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1464170..1464898 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1464914..1464920 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1464932 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1464934..1464945 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1464945) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1464956..1464970) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1464979..1464983) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1464979..1465236 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1464979..1465236 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1465221 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1465253) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1465294..1465297 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1465312..1465331 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1465312 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1465366..1465881 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1465366..1465881 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1465817..1466155 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1465817..1466155 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1466222..1467088 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1466222..1467088 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1466285..1466385 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1466345 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1467048 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1467138..1467719 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1467138..1467719 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1467737..1468987 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1467737..1468987 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1468988..1469114 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1469094..1469101 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1469116..1469135 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1469116 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1469160..1470206 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1469160..1470206 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1470218 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1470263..1470328 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1470300..1470309 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1470322..1470337 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1470330 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1470374..1471549 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1470374..1471549 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1471550..1471649 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1471623..1471630 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1471644..1471663 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1471651..1471824 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1471651 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1471825..1473387 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1471825..1473387 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1473364 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1473456..1474250 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1473456..1474250 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1474005..1474010 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1474026..1474044 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1474046 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1474294..1474299 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1474310..1474449 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1474310 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1474315..1474333 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1474342) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1474353..1474366) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1474375..1474379) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1474386) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1474450..1474710 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1474450..1474710 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1474662 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1474694) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1474706 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1474751..1474925 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1474909..1474916 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1474927 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1474931..1474950 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1474976..1476019 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1474976..1476019 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1476032..1477210 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1476032..1477210 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1477192 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1477290..1477293 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1477302 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1477308..1477327 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1477358..1478887 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1477358..1478887 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1478889..1479320 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1478889..1479320 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1479303 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1479451..1479456 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1479472..1479490 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1479480..1479581 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1479480 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1479582..1480127 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1479582..1480127 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1480121 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1480128) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1480185..1480188 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1480203..1480222 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1480207 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1480260..1482836 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1480260..1482836 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1482852..1484735 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1482852..1484735 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1484638..>1484770) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S611" downshifts 1484650 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1484660) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(1484770,1484777) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_028" N_region 1484771..1484776 /note="EcoRI site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs27_028" CDS complement(1484775..1485035) /gene="ymaG" /locus_tag="PG10_pseudo_BSU_17310" /old_locus_tag="BSU_17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /modified_by="User" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAP*" /label="PG10_pseudo_BSU_17310" gene complement(1484775..1485035) /gene="ymaG" /locus_tag="PG10_pseudo_BSU_17310" /old_locus_tag="BSU_17310" /modified_by="User" /label="PG10_pseudo_BSU_17310" promotor_-35 1485031..1485036 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1485052..1485070 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1485062..1485081) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1485072 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1485075) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1485094..1485103) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1485124..1485537 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1485124..1485537 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1485588 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1485594..1485613 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1485637..1486581 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1485637..1486581 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1486561..1486569 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1486580..1486598 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1486582 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1486621..1486842 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1486621..1486842 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1486632) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1486694..1486698) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1486698) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1486713..1486718) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1486842 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1487038..1487310 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1487038..1487310 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1487326..1487333 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1487347..1487366 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1487349 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1487392..1487622 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1487392..1487622 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1487623..1487699 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1487656 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1487701..1487808 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1487781..1487788 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1487802..1487821 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1487810 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1487865..1488257 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1487865..1488257 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1488217..1490319 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1488217..1490319 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1490337..1491326 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1490337..1491326 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1491286 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1491340..1491999) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1491355) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1491376..1491996 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1491376..1491996 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1491977 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1492012..1492016 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1492034..1492401 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1492034 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1492038..1492055 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1492044) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1492060..1492827) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1492060..1492827) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1492836..1492855) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1492859) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1492868..1492877) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1492981..1492986 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1493002..1493020 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1493002 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1493284..1493289 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1493306..1493324 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1493310..1493450 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1493310 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1493451..1494419 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1493451..1494419 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1494388 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1494483..1494491 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1494498 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1494502..1494521 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1494552..1495814 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1494552..1495814 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1495832..1497097 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1495832..1497097 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1497145..1497152 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1497167..1497186 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1497179 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1497207..1497614 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1497207..1497614 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1497213) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1497595..1497613 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1497620 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1497673) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1497673..1499007 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1497673..1499007 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1498984 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1499029..>1499078 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1499078..1499079 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1499079..1499831 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1499171..1499189) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1499189) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1499205..1499210) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1499832..1501223 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1499832..1501223 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1501254..1502855 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1501254..1502855 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1501370..1501675) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1501670..1501689) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1501675) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1501703..1501711) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1502853 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1502992..1504146) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1502992..1504146) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1502995) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1504045..1504223) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1504191..1504197 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1504206..1504225) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1504207..1504223 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1504217 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1504223) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1504240..1504243) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1504250..1504257 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1504272..1504291 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1504283..1504387 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1504284 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1504388..1505725 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1504388..1505725 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1505726..1505800 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1505757 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1505876..1507375 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1505876..1507375 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1507376..1507691 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1507649 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1507858..1508493) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1507858..1508493) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1508530..1508549) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1508539) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1508564..1508571) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1508681..1508688 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1508703..1508722 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1508705..1508903 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1508705 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1508904..1510319 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1508904..1510319 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1510309 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1510412) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1510421..1511605) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1510421..1511605) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1511606..1511685) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1511678..1511696) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1511689) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1511712..1511717) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1511997..1512004 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1512019..1512038 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1512027 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1512069..1512530 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1512069..1512530 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1512560..1512994 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1512560..1512994 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1512743..1513048) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1512841 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1512995..1514091 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1513050..1513335) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1513093) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1513330..1513349) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1513335) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1513361..1513366) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1513597) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1513597..1513857) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1513597..1513857) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1513878..1513897) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1513888) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1513910..1513919) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1514092..1514217 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1514092..1514217 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1514218..1514334 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1514261..1514425 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1514261..1514425 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1514309..1514318 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1514332..1514351 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1514336..1514646 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1514336 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1514627..1514634 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1514648..1514667 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1514648 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1514699..1515538 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1514699..1515538 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1514721..1514740) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1514742) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1514755..1514758) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1515498 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1515644) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1515645..1515951) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1515661..1515948) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1515661..1515948) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1515688) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1515775..1515783 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1515797..1515816 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1515799 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1515810..1515970 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1515942 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1515991..1516713) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1515991..1516713) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1515996) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1516738..1516757) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1516746) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1516748..1516872) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1516873..1517229) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1516873..1517229) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1517253..1517272) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1517270) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1517288..1517292) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1517469) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1517475..1517675) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1517475..1517675) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1517658 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1517697..1517716) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1517709) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1517729..1517738) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1517850..1518038) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1517850..1518038) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1517866) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1518007..1518014) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1518020) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1518067..1518086) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1518085) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1518101..1518108) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1518117..1518254 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1518117..1518254 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1518148..1518153 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1518168..1518186 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1518186..1518288 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1518186 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1518289..1518687 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1518289..1518687 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1518688..1519492 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1518752..1519186) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1518752..1519186) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1518768) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1519216..1519235) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1519232) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1519249..1519256) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1519493..1519681 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1519493..1519681 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1519682..1519767 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1519726 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1519796..1519802 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1519814..1519973 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1519814 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1519816..1519827 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1519974..1521536 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1519974..1521536 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1520277..1520296) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1520286) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1520311..1520318) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1521566..1522657 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1521566..1522657 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1522647..1523861 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1522647..1523861 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1523939..1523946 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1523961..1523980 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1523972 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1524008..1524814 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1524008..1524814 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1524622..1525720) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1524819..1525436 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1524819..1525436 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1525433..1527073 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1525433..1527073 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1525707..1525726) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1525720) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1525740..1525748) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1526713..1527479) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1527110..1527475 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1527110..1527475 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1527452 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1527472..1527752) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1527472..1527752) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1527481..1527612) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1527524) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1527572..1527581 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1527594..1527603) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1527595..1527614 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1527600 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1527602..1527700 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1527612) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1527614..1527744) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1527701..1528459 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1527701..1528459 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1527734 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1527750..1527769) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1527751) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1527784..1527791) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1528274..1528485) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1528438 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1528483..1529102 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1528486..1529025) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1528486..1529025) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1529026..1529040) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1529032) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1529054..1529060) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1529080..1529089 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1529102..1529117 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1529104 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1529143..1529577 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1529143..1529577 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1529435..1529782 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1529435..1529782 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1529578..1529910 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1529869..1529878 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1529890..1529905 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1529912..1530090 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1529912 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1529981..1530060 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1529981..1530060 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1530047 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1530119..1530736) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1530119..1530736) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1530120) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1530760..1530779) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1530781) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1530793..1530800) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1530816..1530823 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1530835 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1530837..1530856 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1530886..1531203 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1530886..1531203 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1530903..1530921) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1530906) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1530935..1530942) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1531222..1531875 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1531222..1531875 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1531878..1531885 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1531899..1531918 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1531912 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1531939..1532172 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1531939..1532172 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1532173..1532308 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1532276..1532283 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1532297..1532316 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1532310 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1532341..1534344 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1532341..1534344 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1532545..1532564) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1532562) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1534334 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1534346..1535004) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1534444 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1534445..1534464 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1534497..1534943 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1534497..1534943 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1534967..1534986 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1534975 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1534986..1535003) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1535004) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1535022..1535026) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1535029..1535247 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1535029..1535247 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1535259 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1535304..1535603 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1535321..1535494) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1535321..1535494) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1535334) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1535532..1535551) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1535539) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1535565..1535572) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1535574..1535582 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1535594..1535613) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1535594..1535612 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1535605..1535713 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1535605 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1535606) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1535628..1535635) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1535714..1536421 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1535714..1536421 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1536441..1536448 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1536460..1536479 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1536468 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1536510..1536872 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1536510..1536872 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1536890..1536893 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1536908..1536927 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1536919 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1536951..1537442 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1536951..1537442 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1537438 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1537473..1537901) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1537473..1537901) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1537490) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1537919..1537938) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1537931) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1537933..1538018) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1537952..1537959) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1537989..1537998 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1538008..1538117 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1538008 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1538011..1538030 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1538013..1538032) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1538018) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1538020..1538103) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1538047..1538050) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1538074 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1538135..1538527) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1538135..1538527) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1538148) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1538370..1538375 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1538391..1538409 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1538395 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1538505..1538509 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1538519..1538533 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1538534..1538553) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1538536 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1538549) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1538567..1538576) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1538608..1538754) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1538608..1538754) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1538629) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1538786..1538932) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1538786..1538932) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1538932..1539065 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1538932 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1538943..1538945 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1538948..1538959) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1538962) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1538974..1538980) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1539055..1539062 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1539067..1539159 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1539067 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1539077..1539096 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1539118) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1539160..1541889 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1539160..1541889 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1539180..1539184) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1539184) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1541890..1541960 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1541961..1542473 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1541961..1542473 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1542430 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1542499..1542505 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1542518 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1542520..1542531 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1542554..1542679 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1542554..1542679 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1542572) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1542693..1542699 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1542714..1542725 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1542716 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1542744..1542890 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1542744..1542890 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1542927..1543178 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1542927..1543178 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1543156 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1543199..1543204 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1543218..1543237 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1543222..1543313 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1543222 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1543314..1543679 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1543314..1543679 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1543695..1543994 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1543695..1543994 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1543970 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1544025..1544312) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1544025..1544312) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1544046) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1544112) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1544342..1544361) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1544354) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1544377..1544384) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1544400..1544981) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1544400..1544981) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1544982..1545112 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1545007..1545026) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1545024) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1545097..1545100 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1545114 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1545116..1545135 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1545151..1545558 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1545151..1545558 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1545554 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1545620..1545623 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1545638..1545657 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1545642..1545956 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1545642 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1545957..1547924 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1545957..1547924 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1547928..1550348 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1547928..1550348 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1550328 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1550356..1550545) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1550395..1550571) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1550395..1550571) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1550399) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1550546..1550956) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1550546..1550956) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1550929..1550948) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1550932) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1550963..1550970) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1550997..1551016) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1550998) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1551031..1551038) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1551045..1551064) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1551056) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1551078..1551087) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1551304..1551309 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1551322..1551341 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1551327 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1551340..1551404 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1551405..1552802 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1551405..1552802 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1552791 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1552836 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1552892..1553638) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1553015..1553022 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1553034 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1553035..1553054 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1553105..1554604 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1553105..1554604 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1553637..1553656) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1553660) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1553670..1553679) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1554552 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1554672..1554935 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1554672..1554935 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1555194) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1555194..1556462) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1555194..1556462) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1556463..1556592) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1556593..1558134) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1556593..1558134) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1558135..1558456) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1558446..1558465) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1558457) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1558480..1558483) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1558683..1558690 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1558703..1558722 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1558710 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1558729..1559175 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1558729..1559175 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1559182..1560075 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1559182..1560075 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1559692..1559711 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1559700 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1560148..1560744 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1560148..1560744 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1560734 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1560793..1561992) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1560793..1561992) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1561993..1562064) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1562052..1562063) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1562064) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1562078..1562084) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1562162..1563697) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1562162..1563697) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1562174) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1563708..1564490) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1563708..1564490) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1564511..1565410) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1564511..1565410) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1565425..1565646) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1565425..1565646) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1565661..1566995) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1565661..1566995) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1567005..1568654) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1567005..1568654) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1567054..1567154 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1567114 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1568698..1569840) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1568698..1569840) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1569859..1569877) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1569876) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1569893..1569898) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1569931..1570236) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1569931..1570236) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1570226..1570399) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1570226..1570399) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1570507..1572039) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1570507..1572039) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1570518) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1572074..1572093) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1572074) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1572106..1572115) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1572175..1572567) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1572175..1572567) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1572206) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1572595..1572606) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1572602) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1572620..1572626) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1572674,1572681) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1572675..1572680 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1572681..1572786) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1572771..1572790) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1572786) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1572804..1572811) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1573060..1574535) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1573060..1574535) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1573072) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1574569..1575546) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1574569..1575546) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1575575..1575593) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1575587) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1575605..1575613) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1575680..1577071) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1575680..1577071) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1575694) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1575840 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1576861..1576867 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1576881..1576899 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1576892..1577225 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1576892 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1577072..1577176) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1577136..1577236) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1577176) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1577198..1577203 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1577219..1577237 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1577227 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1577285..1577292 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1577305..1577324 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1577308 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1577357..1577902 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1577357..1577902 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1577886 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1577996..1578068) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1577996..1578068) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1578094) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1578121..1578666) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1578121..1578666) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1578706..1578725) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1578720) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1578739..1578746) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1578982..1579212) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1578982..1579212) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1578996) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1579238..1579257) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1579250) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1579269..1579275) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1579304..1579323) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1579314) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1579327..1579334 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1579348..1579367 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1579352 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1579397..1581160 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1579397..1581160 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1581141 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1581261..1582118) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1581261..1582118) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1582164..1582183) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1582184) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1582197..1582204) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1582246..1583235 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1582246..1583235 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1582302..1583260) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1583292..1584773) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1583292..1584773) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1583305) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1584790..1589352) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1584790..1589352) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1587813..1587913 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1587873 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1589353..1589424) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1589404..1589423) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1589421..1589428 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1589424) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1589438..1589445) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1589440 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1589443..1589462 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1589499..1590401 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1589499..1590401 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1590381 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1590453..1591568) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1590453..1591568) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1591565..1592458) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1591565..1592458) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1592463..1592482) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1592471 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1592481) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1592496..1592502) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1592511..1592529) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1592529) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1592545..1592550) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1592606..1592974) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1592606..1592974) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1593009..1593027) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1593032) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1593034..1593153) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1593039..1593047) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1593145..1593164) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1593153) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1593155..1593251) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1593179..1593186) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1593274..1593990) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1593274..1593990) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1593296) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1594028..1594047) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1594037) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1594063..1594066) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1594091..1594097 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1594111..1594129 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1594116 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1594141..1594446 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1594141..1594446 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1594430 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1594517..1595287 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1594517..1595287 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1595269..1595276 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1595288 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1595291..1595310 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1595331..1595864 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1595331..1595864 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1595865..1595950 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1595907 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1595943..1597187) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1595943..1597187) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1595952..1596691 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1595957) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1597188..1597280) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1597281..1598744) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1597281..1598744) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1598762..1599796) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1598762..1599796) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1599808..1599879) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1599851) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1599880..1599971) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1599880..1599971) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1599999..1600018) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1600011) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1600033..1600040) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1600053..1600060 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1600074..1600093 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1600078 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1600120..1602162 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1600120..1602162 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1602170..1602179 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1602192..1602207 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1602195 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1602229..1602522 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1602229..1602522 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1602502 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1602547..1602894) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1602578) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1602895..1603299) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1602895..1603299) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1603300..1603395) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1603385..1603400) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1603385..1603504) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1603385..1603504) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1603395) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1603413..1603422) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1603500..1603506 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1603520..1603531 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1603531..1603739 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1603531 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1603574..1603696 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1603574..1603696 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1603740..1604033 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1603740..1604033 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1604034..1604127 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1604084 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1604149..1605834) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1604149..1605834) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1604161) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1605835..1605922) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1605914..1605932) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1605922) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1605946..1605953) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1606091..1606100 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1606110 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1606113..1606132 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1606159..1607610 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1606159..1607610 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1607586 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1607647..1608345) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1607647..1608345) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1607662) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1608380..1608399) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1608399) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1608401..1608614) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1608413..1608420) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1608615..1609292) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1608615..1609292) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1609293..1611782) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1609465..1610502 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1609465..1610502 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1610699..1610705 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1610720..1610731 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1610732 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1610759..1611442 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1610759..1611442 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1611783..1612088) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1611783..1612088) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1612089..1612190) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1612169..1612188) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1612190) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1612203..1612210) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1612218..1612320) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1612260) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1612321..1613499) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1612321..1613499) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1613525..1613544) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1613544) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1613558..1613567) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1613622..1614110) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1613622..1614110) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1613647) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1614135..1614290) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1614135..1614290) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1614330..1615085) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1614330..1615085) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1615338..1615343 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1615359..1615377 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1615374 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1615393..1615749 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1615393..1615749 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1615708..1615947) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1615708..1615947) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1615750..1616186 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1615948..1616049) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1616050..1616547) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1616050..1616547) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1616548..1616647) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1616648..1617559) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1616648..1617559) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1617581..1617592) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1617583) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1617607..1617613) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1617843..1617850 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1617859 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1617865..1617884 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1617906..1618388 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1617906..1618388 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1618398..1618652 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1618398..1618652 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1618653..1618757 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1618758..1619552 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1618758..1619552 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1619553..1620563 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1619676..1620548) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1619676..1620548) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1620649..1621527 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1620649..1621527 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1621640..1621699) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1621675) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1621700..1622131) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1621700..1622131) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1622151..1622170) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1622159) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1622161..1622394) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1622184..1622190) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1622395..1622413) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1622395..1623027) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1622395..1623027) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1622401) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1622429..1622434) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1623165..1623172 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1623187..1623206 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1623191 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1623253..1624173 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1623253..1624173 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1623684..1623703) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1623699) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1623718..1623725) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1624174..1624831 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1624670..1625032) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1624670..1625032) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1625093..1625305) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1625093..1625305) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1625344..1625351 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1625366..1625385 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1625369 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1625409..1625672 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1625409..1625672 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1625650 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1626049..1628649) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1626049..1628649) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1628650..1628759) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1628675..1628682 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1628697..1628716 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1628705..1629332 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1628705 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1628749..1628768) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1628759) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1628783..1628789) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1628805..1629264) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1628847) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1629309) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1629319..1629960) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1629319..1629960) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1629961..1630078) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1630055..1630074) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1630078) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1630088..1630090) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1630166,1630173) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1630167..1630172 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1630173..1630257 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1630173..1630250 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1630173..1630237) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1630173..1630257 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1630235 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1630268..1630600) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1630268..1630600) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1630282) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1630665..1631390) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1630665..1631390) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1631405..1632148) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1631405..1632148) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1632176..1632195) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1632195) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1632209..1632215) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1632226..1632801) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1632226..1632801) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1632807..1633508) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1632807..1633508) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1633538..1633557) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1633538) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1633542..1633557) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1633572..1633579) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1633572..1633579) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1633582) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1633585..1634067) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1633585..1634067) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1634106..1634123) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1634110) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1634121..1635062) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1634121..1635062) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1634154) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1635092..1635111) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1635100) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1635125..1635129) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1635133..1635142 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1635155..1635174 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1635163 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1635178..1635242 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1635214..1635219 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1635235..1635253 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1635244 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1635268..1635813 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1635268..1635813 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1635772 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1635840..1636163) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1635840..1636163) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1635847) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1636184..1636203) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1636195) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1636216..1636223) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1636284..1636290 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1636301 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1636305..1636324 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1636357..1637034 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1636357..1637034 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1637026 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1637124..1637660) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1637124..1637660) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1637147) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1637687..1637706) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1637707) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1637720..1637727) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1637797..1638579) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1637797..1638579) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1637806) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1638601..1638619) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1638620) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1638633..1638639) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1638676..1638683 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1638698..1638717 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1638702 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1638750..1639247 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1638750..1639247 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1639254..1639257 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1639273..1639292 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1639275 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1639311..1640288 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1639311..1640288 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1640260 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1640385..1640392 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1640407..1640426 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1640414 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1640450..1641508 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1640450..1641508 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1641509..1641578 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1641562..1641568 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1641580..1641599 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1641580 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1641628..1642740 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1641628..1642740 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1642759..1643358 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1642759..1643358 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1643296 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1643340 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1643380..1643878) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1643416) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1643850..1643859 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1643862..1643880) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1643871..1644065 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1643871 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1643872..1643891 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1643878) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1643897..1643902) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1643953..1644816) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1643953..1644816) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1643966) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1644022 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1644054) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1644067..1644834 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1644812..1644816 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1644825..1644839 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1644836 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1644855..1644874) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1644868) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1644870..1645063) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1644886..1644892) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1645064..1646839) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1645064..1646839) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1646840..1646970) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1646963..1647165) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1646963..1647165) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1647015) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1647163..1647182) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1647181) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1647183..1647375) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1647195..1647202) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1647404..1648030) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1647404..1648030) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1647420) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1648064..1648083) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1648077) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1648097..1648104) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1648181..1648672) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1648181..1648672) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1648190) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1648684..1648702) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1648696) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1648716..1648722) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1648747..1649079) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1648747..1649079) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1649080..1649370) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1649095..1649100 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1649115..1649133 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1649117 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1649157..1649384 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1649157..1649384 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1649371..1649847) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1649371..1649847) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1649385..1649892 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1649848..1649950) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1649865..1649870 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1649885..1649903 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1649894 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1649914..1650177 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1649914..1650177 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1649930..1649949) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1649950) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1649952..1650477) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1649963..1649967) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1650182..1650415 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1650182..1650415 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1650402 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1650501..1650845) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1650501..1650845) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1650522) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1650846..1650918) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1650914..1650933) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1650918) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1650920..1651023) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1650947..1650952) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1651010..1651025) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1651023) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1651038..1651047) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1651166) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1651202..1651405) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1651202..1651405) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1651426..1651445) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1651444) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1651446..1651512) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1651461..1651468) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1651478..1651485 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1651497 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1651499..1651511) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1651499..1651518 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1651502..1651634 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1651523) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1651635..1653122 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1651635..1653122 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1652078..1652095) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1652084) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1652108..1652116) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1653108 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1653170..1653175 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1653191..1653209 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1653196 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1653223..1655121 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1653223..1655121 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1654166..1654185) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1654174) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1654199..1654208) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1655111..1655956 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1655111..1655956 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1655957..1657463 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1655989..1657326) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1655989..1657326) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1656000) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1657354..1657373) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1657369) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1657371..1658529) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1657388..1657395) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1657447..1657450 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1657465..1657484 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1657465 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1657545..1658510 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1657545..1658510 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1658498 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1658560..1659813) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1658560..1659813) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1658574) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1659829..1662663) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1659829..1662663) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1662758..1662777) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1662773) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1662775..1662891) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1662792..1662799) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1662892..1664808) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1662892..1664808) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1664819..1665733) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1664819..1665733) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1665737..1665756) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1665752) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1665773..1665777) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1665797..1666387) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1665797..1666387) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1666480..1667724) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1666480..1667724) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1666482) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1667787..1667805) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1667800) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1667802..1668022) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1667818..1667825) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1668008..1668026) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1668022) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1668038..1668046) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1668106..1669323) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1668106..1669323) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1668132) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1669356..1669375) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1669364) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1669389..1669396) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1669559..1670182) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1669559..1670182) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1670183..1670333) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1670209..1670215 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1670221 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1670229..1670240 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1670247..1670255 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1670263..1670363 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1670267..1670285 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1670278 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1670316..1670334) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1670323..1670408 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1670323 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1670333) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1670350..1670356) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1670384..1670391 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1670404..1670423 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1670410 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1670448..1671806 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1670448..1671806 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1670790..1670801) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1670795) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1670815..1670821) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1671822..1672670 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1671822..1672670 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1672086..1672105) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1672093) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1672119..1672127) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1672633 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1672665) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1672696..1673361) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1672696..1673361) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1672710) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1673380..1673730) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1673380..1673730) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1673727..1674005) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1673727..1674005) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1674032..1674051) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1674048) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1674066..1674072) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1674081..1674977) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1674081..1674977) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1674819..1674828 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1674839 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1674842..1674861 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1674857..1675075 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1675001..1675020) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1675021) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1675032..1675039) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1675076..1675549 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1675076..1675549 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1675546 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1675584..1675820) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1675584..1675820) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1675592) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1675843..1675862) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1675858) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1675876..1675885) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1675905..1677239) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1675905..1677239) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1677240..1677375) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1677372..1677391) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1677382) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1677406..1677413) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1677471..1677478 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1677493..1677512 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1677496 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1677497..1677603 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1677604..1677993 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1677604..1677993 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1678003 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1678400..1678738) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1678400..1678738) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1678761..1678768 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1678782..1678801 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1678791 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1678795..1678867 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1678826..1678845) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1678829) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1678857..1678863) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1678868..1679476 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1678868..1679476 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1679466 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1679519..1680121) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1679519..1680121) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1680137..1681048) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1680137..1681048) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1681077..1681096) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1681093) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1681112..1681117) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1681169..1681172 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1681187..1681206 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1681189 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1681232..1681432 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1681232..1681432 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1681432..1682922 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1681432..1682922 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1682167..1682178) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1682171) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1682192..1682198) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1682910 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1682957..1684357) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1682957..1684357) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1682981) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1684128..1684137 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1684149..1684164 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1684163 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1684377..1684396) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1684397) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1684410..1684417) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1684456..1684465 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1684471 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1684478..1684497 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1684510..1685211 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1684510..1685211 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1685236..1685244 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1685258..1685277 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1685263 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1685299..1685550 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1685299..1685550 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1685571 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1685621..1686442) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1685621..1686442) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1685647) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1686443..1686524) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1686525..1687226) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1686525..1687226) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1687227..1687316) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1687301..1687320) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1687316) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1687336..1687340) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1687374..1687380 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1687395..1687406 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1687412 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1687428..1687553 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1687428..1687553 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1687551 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1687593..1687907) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1687593..1687907) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1687605) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1687928..1687946) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1687935) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1687957..1687965) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1687968..1688579) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1687968..1688579) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1688657..1688833) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1688657..1688833) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1688661) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1688672) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1688676..1688695) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1688711..1688714) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1688847..1688865) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1688868) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1688870..1689091) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1688881..1688886) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1688891..1688896 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1688911..1688929 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1688913 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1688952..1689095 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1688952..1689095 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1689092..1689772) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1689092..1689772) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1689096..1690107 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1689799..1689818) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1689805) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1689832..1689841) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1689923..1690147) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1689923..1690147) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1689937) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1690188..1690207) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1690200) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1690234..1690512) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1690234..1690512) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1690509..1691924) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1690509..1691924) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1691180..1691183 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1691199..1691218 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1691204 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1691953..1692780) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1691953..1692780) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1692758..1694068) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1692758..1694068) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1694077..1694730) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1694077..1694730) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1694715..1695404) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1694715..1695404) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1695411..1696745) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1695411..1696745) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1696726..1696881) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1696726..1696881) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1696764..1696782) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1696780) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1696798..1696803) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1696875..1697108) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1696875..1697108) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1696882) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1696984..1696988 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1696997..1697011 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1697012 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1697013..1697032) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697022) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1697047..1697056) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1697068..1697847) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1697068..1697847) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1697876..1699156) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1697876..1699156) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1698524..1698542) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1698540) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1698556..1698563) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1699124..1699142) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1699134) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1699158..1699163) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1699221..1699526) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1699221..1699526) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1699354) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1699550..1699569) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1699565) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1699583..1699592) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1699662..1699671 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1699685..1699704 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1699685 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1699706) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1699708..1699722) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1699731..1699735) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1699731..1700132 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1699731..1700132 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1700139..1701092 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1700139..1701092 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1701082 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1701163..1702311) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1701163..1702311) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1701180) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1702324..1702328 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1702337..1702356) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1702344..1702363 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1702346) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1702354 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1702615..1702623 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1702637..1702656 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1702640 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1702681..1703706 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1702681..1703706 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1703084 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1703086..1703090 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1703100..1703101 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1703698 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1703750..1704181) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1703750..1704181) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1703755) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1704182..1704715) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1704182..1704715) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1704719..1704725 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1704736..1704846 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1704736 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1704738..1704757 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1704743..1704762) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1704763) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1704778..1704779) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1704847..1705272 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1704847..1705272 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1705260 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1705305..1706536 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1705322..1706659) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1705322..1706659) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1706731..1706925) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1706731..1706925) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1706744) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1706938..1707501) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1706938..1707501) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1707511..1708278) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1707511..1708278) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1708302..1708321) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1708319) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1708332..1708339) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1708356..1708937) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1708356..1708937) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1708938..1709053) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1709085..1709336) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1709085..1709336) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1709098) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1709359..1709378) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1709373) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1709422..1710690) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1709422..1710690) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1710724..1710743) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1710743) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1710755..1710762) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1710897..1710916 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1710900 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1710939..1711934 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1710939..1711934 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1711955..1712596 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1711955..1712596 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1712597..1713698 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1712635..1713255) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1712635..1713255) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1712661) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1713256..1713762) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1713256..1713762) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1713759..1714553) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1713759..1714553) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1714637..1715170) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1714637..1715170) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1714642) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1715100..1715105 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1715116..1716062 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1715118 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1715122..1715140 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1715188..1715799) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1715188..1715799) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1715831..1715850) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1715850) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1715863..1715868) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1716019 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1716059..1716832) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1716059..1716832) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1716094) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1716874..1717308) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1716874..1717308) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1716886) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1717337..1717356) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1717348) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1717350..1717414) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1717370..1717377) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1717393) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1717415..1719091) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1717415..1719091) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1719092..1719282) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1719271..1719290) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1719282) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1719305..1719308) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1719380..1720513) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1719380..1720513) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1719396) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1720535..1720554) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1720538) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1720573..1721190) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1720573..1721190) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1721206..1721688) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1721206..1721688) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1721689..1721836) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1721827..1721845) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1721837) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1721856..1721864) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1721890..1721899 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1721912..1721927 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1721914..1722000 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1721914 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1721963..1721970 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1721985..1722004 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1722002 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1722031..1722936 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1722031..1722936 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1722971..1722990 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1722985 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1722986..1723166 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1723167..1724315 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1723167..1724315 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1723336..1724365) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1724311 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1724347..1724366) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1724365) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1724381..1724389) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1724396..1724542 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1724396..1724542 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1724435..1724442 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1724456..1724475 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1724467..1724557 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1724467 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1724558..1724758 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1724558..1724758 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1724773 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1724810..1724992) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1724810..1724992) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1724818..1725123 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1724827) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1725053..1725071) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1725085..1725091) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1725089) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1725099..1725105 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1725120..1725131 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1725125 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1725148..1725417 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1725148..1725417 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1725272 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1725400 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1725445..1725627) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1725445..1725627) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1725465) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1725620..1726300) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1725620..1726300) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1726301..1726438) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1726317..1726322 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1726335..1726354 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1726340 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1726383..1727072 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1726383..1727072 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1726436..1726452) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1726439) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1726440..1726829) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1726810..1726829) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1726827) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1726841..1726849) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1727072..1727470 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1727072..1727470 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1727463..1727469 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1727484..1727495 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1727495 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1727512..1727640 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1727512..1727640 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1727641..1728621 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1727648..1728538) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1727648..1728538) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1727685) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1728560..1728579) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1728567) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1728591..1728597) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1728595 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1728639..1728785) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1728639..1728785) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1728655) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1728809) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1728810..1728821) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1728836..1728842) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1728860..1729117) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1728860..1729117) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1729137..1729156) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1729152) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1729168..1729175) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1729182..1732763) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1729182..1732763) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1732764..1732835) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1732825..1732844) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1732835) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1732880..1733077) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1732923) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1732939..1733028) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1732939..1733028) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1733056..1733075) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733077) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733090..1733097) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1733099..1733605) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1733099..1733605) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1733609..1734706) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1733609..1734706) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1734724..1734735) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1734727) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1734750..1734756) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1734780..1736096) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1734780..1736096) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1734793) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1736093..1736677) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1736093..1736677) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1736766..1736866) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1736766..1736866) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1736773) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1736867..1737007) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1737008..1738513) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1737008..1738513) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1738449..1738549) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1738489) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1738501 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1738539..1738558) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1738555) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1738572..1738579) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1738625..1739617) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1738625..1739617) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1738643) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1739662..1740252) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1739662..1740252) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1740254..1741228) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1740254..1741228) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1741266..1742285) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1741266..1742285) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1742333..1742352) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1742343) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1742364..1742371) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1742406..1742413 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1742427..1742506 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1742427 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1742428..1742447 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1742507..1743334 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1742507..1743334 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1743336..1744100 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1743336..1744100 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1744089 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1744131) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1744141..1746066) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1744141..1746066) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1746097..1746116) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1746101) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1746103..1746167) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1746131..1746135) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1746168..1746359) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1746168..1746359) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1746378..1746396) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1746387) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1746389..1746694) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1746412..1746417) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1746426..1746432 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1746447..1746458 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1746456 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1746523..1746675 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1746523..1746675 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1746685 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1746728..1747885) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1746728..1747885) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1746739) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1747973..1748373) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1747973..1748373) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1747983) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1748370..1748389) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1748388) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1748404..1748410) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1748432..1748728) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1748432..1748728) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1748753..1748772) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1748763) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1748786..1748793) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1748806..1749435) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1748806..1749435) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1749401) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1749437..1749664) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1749437..1749664) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1749692..1749711) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1749707) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1749709..1749863) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1749725..1749733) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1749748..1749876) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1749748..1749876) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1749863) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1749865..1749976) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1749866..1749885) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1749901..1749905) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1749977..1751218) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1749977..1751218) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1750932..1750950) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1750941) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1750965..1750972) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1751234..1753483) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1751234..1753483) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1753499..1753518) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1753515) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1753532..1753538) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1753586..1754092) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1753586..1754092) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1753609) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1754136..1754155) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1754153) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1754169..1754176) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1754174..1754183 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1754197..1754216 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1754209 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1754230..1754649 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1754230..1754649 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1754650..1754800 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1754670..1755047) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1754670..1755047) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1754703) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1755045..1755190 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1755077..1755095) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755096) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755109..1755118) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1755191..1755210 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1755192 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1755235..1755423 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1755235..1755423 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1755439 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1755462..1755833) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1755462..1755833) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1755495) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1755845..1755864) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755858) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1755877..1755882) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1755879..1756124) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1755879..1756124) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1756150..1756168) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1756155) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1756180..1756188) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1756274..1756280 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1756295..1756306 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1756302 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1756323..1756427 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1756323..1756427 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1756409 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1756452..1757414) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1756452..1757414) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1756582..1756591 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1756603..1756618 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1756603 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1756607..1756942 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1756913..1756917 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1756933..1756952 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1756944..1757454 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1756944 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1757415..1757871) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1757455..1758075 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1757455..1758075 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1757860..1757871) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1757871) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1757886..1757892) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1758097..1760841 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1758097..1760841 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1760511) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1760827 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1760917..1761411) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1760917..1761411) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1760930) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1761408..1762067) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1761408..1762067) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1762086..1762784) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1762086..1762784) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1762785..1762876) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1762877..1764169) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1762877..1764169) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1764170..1764231) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1764231..1764250) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1764231) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1764265..1764272) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1764313..1765494) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1764313..1765494) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1764317) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1765517..1766002) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1765517..1766002) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1765950..1765969) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1765967) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1765982..1765989) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1766011..1766181) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1766011..1766181) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1766182..1766253) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1766215..1766221 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1766236..1766255) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1766236..1766247 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1766243..1766317 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1766243 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1766253) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1766255..1766323) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1766271..1766277) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1766287 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1766324..1769119) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1766324..1769119) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1766792..1766796 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1766793 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1766798..1766802 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1767449..1767464) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1767463) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1767477..1767486) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1769120..1769244) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1769245..1769628) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1769245..1769628) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1769630..1770490) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1769630..1770490) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1770492..1771325) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1770492..1771325) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1771326..1771533) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1771528..1771547) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1771533) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1771564..1771568) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1771571..1772548) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1771571..1772548) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1772533..1773726) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1772533..1773726) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1773731..1774864) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1773731..1774864) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1774861..1775571) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1774861..1775571) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1775564..1775977) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1775564..1775977) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1775993..1776796) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1775993..1776796) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1776808..1777143) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1776808..1777143) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1777163..1777182) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1777173) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1777196..1777203) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1777212..1777219 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1777228..1777247) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1777233..1777252 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1777239 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1777247) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1777283..1778155 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1777283..1778155 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1778197..1778991) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1778197..1778991) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1778222) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1778992..1779059) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1779060..1779617) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1779060..1779617) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1779618..1779697) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1779742) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1779764..1780531) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1779764..1780531) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1780566..1781240) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1780566..1781240) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1781242..1781745) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1781242..1781745) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1781754 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1781809..1781828) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1781809) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1781843..1781850) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1781888..1782334) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1781888..1782334) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1782337 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1782389..1782928) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1782389..1782928) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1782402) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1782961..1782979) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1782972) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1782991..1782999) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1783000..1784271) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1783000..1784271) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1784272..1784339) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1784336..1784355) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1784339) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1784369..1784376) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1784406..1784425) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1784412) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1784414..1784558) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1784436..1784443) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1784540..1784558) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1784558) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1784574..1784579) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1784607..1785893) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1784607..1785893) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1784630) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1785904..1787019) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1785904..1787019) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1787068..1788150) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1787068..1788150) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1788161..1788964) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1788161..1788964) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1788649..1788668) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1788666) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1788680..1788687) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1788957..1790159) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1788957..1790159) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1790140..1790787) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1790140..1790787) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1790234) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1790410..1790413) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1790410) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1790630) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1790792..1791544 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1790792..1791544) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1790792..1791544) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1790825..1790827) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1790828 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1790934,1790937) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1790948,1790950) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1790950,1790952) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1790975,1790977) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1790977,1790981) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1790983,1790985) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1790992,1790994) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791007,1791009) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791010,1791012) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791015,1791017) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791025,1791027) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791028,1791030) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791031,1791033) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791037,1791039) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791063,1791065) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791095,1791097) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791148,1791150) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791196,1791198) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791211,1791215) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791229,1791231) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791238,1791240) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791250,1791252) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791315,1791317) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791325,1791327) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791333,1791336) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791353,1791355) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791369,1791371) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791397,1791399) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791412,1791414) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791437,1791439) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791454,1791456) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1791469,1791471) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1791537..1792553) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1791537..1792553) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1792525..1794072) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1792525..1794072) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1794151..1794282) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1794194) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1794273..1794292) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1794282) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1794288..1794671) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1794288..1794671) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1794307..1794314) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1794668..1795756) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1794668..1795756) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1794797..1794812) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1794810) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1794825..1794833) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1795756..1796928) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1795756..1796928) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1796963..1796982) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1796980) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1796995..1797002) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1797003..1797773) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1797003..1797773) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1797799..1797818) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1797816) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1797830..1797836) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1797848..1798009) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1797891) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1798010..1798459) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1798010..1798459) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1798502..1798521) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1798509) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1798534..1798541) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1798575..1799621) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1798575..1799621) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1799563..1800264) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1799563..1800264) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1800271..1801026) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1800271..1801026) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1801027..1801112) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1801101..1801120) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1801112) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1801131..1801138) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1801190..1801417) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1801190..1801417) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1801211) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1801439..1802011) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1801439..1802011) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1802040..1802059) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1802050) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1802052..1802135) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1802072..1802078) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1802180) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1802199..1802477) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1802199..1802477) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1802478..1802703) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1802685..1802704) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1802703) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1802721..1802726) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1802851..1804329) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1802851..1804329) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1802864) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1804330..1804491) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1804478..1804496) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1804503) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1804510..1805244) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1804510..1805244) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1804511..1804516) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1804536) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1805266..1805469) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1805266..1805469) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1805505..1805524) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1805526) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1805538..1805545) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1805591..1805790) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1805634) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1805765..1805784) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1805790) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1805798..1805807) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1805807..1806844) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1805807..1806844) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1806862..1808172) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1806862..1808172) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1808173..1808297) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1808283..1808302) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1808297) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1808317..1808320) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1808326..1808520) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1808326..1808520) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1808517..1809410) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1808517..1809410) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1809407..1810006) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1809407..1810006) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1809879..1809885 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1809894..1810077 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1809896 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1809899..1809910 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1810017..1810035) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1810036) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1810051..1810056) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1810084..1810215 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1810084..1810215 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1810203 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1810258..1811307) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1810258..1811307) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1810278) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1811182) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1811320..1812468) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1811320..1812468) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1811649..1811652 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1811676 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1811742 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1812446 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1812469..1812608) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1812607..1812626) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1812608) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1812610..1812700) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1812641..1812648) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1812701..1813375) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1812701..1813375) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1813376..1813453) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1813454..1813630) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1813454..1813630) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1813642..1813660) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1813659) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1813675..1813681) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1813675..1814328) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1813675..1814328) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1814358..1814377) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1814371) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1814393..1814397) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1814421..1815773) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1814421..1815773) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1814436) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1815808..1816725) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1815808..1816725) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1816196) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1816347..1816354) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1816350) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1816763..1816774) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1816772) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1816788..1816794) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1816864..1817520) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1816864..1817520) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1816878) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1817545..1817564) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1817560) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1817640..1818614) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1817640..1818614) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1817648) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 1818468..1818473 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1818489..1818507 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1818499..1818692 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 1818499 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 1818650 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1818723..1820006) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(1818723..1820006) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(1818726) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 1818764..1818770 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1818782..1818786 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1818782 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1820049..1820068) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1820070) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1820083..1820090) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1820162..1820746) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(1820162..1820746) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(1820164) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(1820747..1820828) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(1820821..1820840) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(1820828) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(1820854..1820861) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(1820905..1821684) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(1820905..1821684) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(1821710..1821725) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(1821721) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(1821737..1821746) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(1821770..1822213) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(1821770..1822213) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(1821787) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1822276..1822998) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(1822276..1822998) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(1822557) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(1822949..1823518) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(1822949..1823518) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(1823267..1823285) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1823283) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1823300..1823306) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1823537..1824283 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(1823578..1825068) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(1823578..1825068) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(1825061..1826119) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(1825061..1826119) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 1825409..1825418 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1825429..1826219 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 1825429 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1825431..1825450 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1826160..1826179) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1826183) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1826191..1826198) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1826197..1826203 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 1826217..1826236 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 1826221..1826290 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 1826221 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 1826270..1826277 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1826292..1826384 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 1826292..1826311 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1826292 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 1826385..1826633 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 1826385..1826633 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 1826617 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1826673..1827245) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(1826673..1827245) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(1826693) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1827237..1827544) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(1827237..1827544) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(1827246..1827350) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(1827543..1827562) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1827559) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1827576..1827582) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1827671..1827678 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1827689 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1827693..1827712 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1827742..1829319 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 1827742..1829319 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 1829301 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(1829362..1830129) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(1829362..1830129) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(1829377) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1829631..1830243 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(1830156..1830175) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1830169) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1830190..1830193) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1830203 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(1830241..1831347) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(1830241..1831347) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(1830258) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(1831283..1831867) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(1831283..1831867) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 1831661..1831666 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1831677 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1831681..1831685 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1831818..1831823 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1831835 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1831839..1831857 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1831875 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1831916..1831935) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1831920..1832027 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(1831924) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1831948..1831955) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1831983 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(1832012..1832070) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(1832043) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1832071..1833840) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(1832071..1833840) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(1832127) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(1833837..1834559) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(1833837..1834559) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(1834560..1834639) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(1834640..1835815) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(1834640..1835815) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(1835835..1837463) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(1835835..1837463) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(1837460..1837999) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(1837460..1837999) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(1838000..1838093) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(1838094..1838828) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(1838094..1838828) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(1838837..1838856) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1838860) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1838871..1838875) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1838920..1839456) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(1838920..1839456) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(1838925..1838944) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1838929) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1838959..1838966) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1839461..1840051) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(1839461..1840051) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(1840039..1841187) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(1840039..1841187) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(1841209..1841227) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1841216) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1841242..1841247) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1841310..1841849) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(1841310..1841849) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(1841323) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1841858..1841875) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1841873) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1841890..1841895) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1841904..1842497) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(1841904..1842497) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(1842487..1843242) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(1842487..1843242) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 1843086..1843095 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1843108..1843127 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1843117 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1843288..1843307) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1843303) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1843321..1843328) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1843468..1843475 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1843486..1843505 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1843491 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 1843523..1844047 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 1843523..1844047 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(1844061..1844435) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(1844061..1844435) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(1844077) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1844497..1844516) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1844509) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1844528..1844535) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1844548..1845012) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(1844548..1845012) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 1844883..1844887 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1844901..1844905 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1844904 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1845045..1846241) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(1845045..1846241) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(1846256..1846903) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(1846256..1846903) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(1846914..1847999) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(1846914..1847999) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(1848000..1848128) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(1848129..1848273) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(1848129..1848273) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(1848290..1848309) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1848300) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1848324..1848331) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1848393..1848737) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(1848393..1848737) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(1848408) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1848769..1848787) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1848782) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1848796..1848801 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1848802..1848808) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1848816..1849738 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 1848816 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1848817..1848835 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1848823..1848838) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1848826) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1848828..1848894) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(1848851..1848860) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1848889..1848897) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1848894) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1848911..1848919) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1848972..1849526) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(1848972..1849526) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(1848982) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1849552..1849571) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1849570) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1849572..1849971) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(1849583..1849589) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1849793..1850029 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 1849793..1850029 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(1849972..1850178) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(1849972..1850178) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(1850211..1850230) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1850233) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(1850287..1850541) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(1850287..1850541) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 1850421..1850430 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1850432..1850821) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(1850432..1850821) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 1850444..1851515 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 1850444..1850463 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1850444 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1850799..1851002) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(1850799..1851002) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 1851411..1851527 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 1851411..1851527 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 1851478 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 1851604..1851613 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1851626..1851645 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1851626 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1851668..1851880 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 1851668..1851880 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 1851874 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(1852016) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1852016..1852447) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(1852016..1852447) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(1852448..1852534) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(1852517..1852536) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1852534) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1852550..1852555) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1852584..1852593 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1852603..1852700 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 1852603 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1852606..1852621 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1852701..1853573 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 1852701..1853573 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 1853480 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1853546 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1853603..1854922) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(1853603..1854922) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(1853623) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1854923..1854987) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(1854983..1855002) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1854987) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1855017..1855024) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1855028..1855646) /gene="spoVAF" /locus_tag="PG10_5'_ext_BSU_23390" /old_locus_tag="BSU_23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /modified_by="User" /translation="MTTSSGKIFRYSCFYFISSDLVSLCASA*SAPGQHEIYRFK*RY AYPDHPADIFS*LRNRVSQNGCHSHTDGFIDSNGFNCRCSDRADCD*GRPFFS*GDSV RLTCGDWNLYDA*L*IKLGKQNEPSCPHDTRCFISYKRARHRIYSANYCHGKHQIPSD TVLMAADSL*RKGAVAGSCPHSETWRKSKTQHRSPQKSLKAAYQFI" /label="PG10_5'_ext_BSU_23390" gene complement(1855028..1855646) /gene="PG10_5'_ext_BSU_23390" /locus_tag="PG10_pseudo_BSU_23390" /old_locus_tag="BSU_23390" /modified_by="User" /label="PG10_5'_ext_BSU_23390" SCAR join(1855632,1855639) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs23" N_region 1855633..1855638 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs23" S_feature complement(<1855639..1855655) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" CDS complement(1855656..1856825) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(1855656..1856825) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(1856854..1856865) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1856869) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1856879..1856885) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1856971) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1856980..1857795) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(1856980..1857795) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(1857808..1858992) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(1857808..1858992) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(1859041..1859060) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1859059) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1859061..1859152) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(1859076..1859083) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1859153..1860043) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(1859153..1860043) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(1860051..1860278) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(1860051..1860278) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(1860181..1860200) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1860192) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1860214..1860221) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1860271) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1860280..1860298) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1860308..1860326) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1860314..1860320) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1860321) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1860343..1860348) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1860403) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(1860403..1860852) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(1860403..1860852) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(1860876..1860895) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(1860886) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(1860888..1860964) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(1860911..1860915) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(1860965..1861609) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(1860965..1861609) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(1861640..1861658) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(1861657) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(1861673..1861678) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(1861710..1861925) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(1861710..1861925) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(1861790) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1862025..1863344) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(1862025..1863344) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(1862032) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(1863362..1864768) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(1863362..1864768) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(1864816..1864835) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1864825) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1864827..1864908) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(1864850..1864857) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1864909..1866336) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(1864909..1866336) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(1866381..1867370) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(1866381..1867370) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(1867371..1867450) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(1867432..1867451) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1867450) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1867452..1867772) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(1867466..1867473) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1867491..1867498 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1867511..1867530 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1867513 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 1867552..1867902 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 1867552..1867902 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(1867774..1867910) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(1867817) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(1867911..1869074) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(1867911..1869074) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(1869071..1869628) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(1869071..1869628) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(1869558..1869658) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1869598) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1869642..1869647 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1869663..1869681 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1869665..1869679) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 1869669 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 1869676..1869850 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(1869681..1869684) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(1869684) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 1869703..1869825 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 1869703..1869825 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 1869826..1869833 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1869847..1869866 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1869852 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 1869888..1870808 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 1869888..1870808 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 1870797 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1870840..1871064) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(1870840..1871064) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(1870897) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1871087..1871106) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1871094) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1871121..1871128) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1871143..1871150 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1871165..1871184 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1871172 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 1871226..1872143 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 1871226..1872143 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 1872118 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(1872183..1872422) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(1872183..1872422) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(1872194) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1872435..1872758) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(1872435..1872758) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(1872501..1872520) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1872502) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1872534..1872541) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1872755..1873786) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(1872755..1873786) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(1872782..1872801) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1872789) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1872812..1872819) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1873779..1874123) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(1873779..1874123) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(1874133..1874603) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(1874133..1874603) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(1874604..1874680) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 1874604 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1874655..1874674) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1874680) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1874682..1874788) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(1874689..1874696) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1874789..1875127) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(1874789..1875127) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(1875124..1876362) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(1875124..1876362) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 1875286..1875287 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1875297 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1875352 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1876387..1876405) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(1876396) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(1876422..1876427) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 1876467..1876470 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1876485..1876504 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1876494 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 1876528..1876734 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 1876528..1876734 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 1877217..1877220 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1877235..1877254 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1877251 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 1877283..1878515 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 1877283..1878515 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 1878362..1878724 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 1878362..1878724 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(1878541..1878720) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(1878574) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1878721..1879107) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(1878721..1879107) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(1879111..1880070) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(1879111..1880070) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(1880071..1880141) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(1880142..1881488) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(1880142..1881488) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(1881489..1881563) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(1881564..1882343) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(1881564..1882343) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(1882349..1883308) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(1882349..1883308) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(1883330..1883349) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1883349) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1883364..1883371) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1883405..1883412 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1883426..1883712 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 1883426 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1883428..1883447 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1883442..1883687 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 1883442..1883687 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 1883713..1884549 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 1883713..1884549 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 1884547 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1884590..1886233) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(1884590..1886233) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(1884602) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1886251..1886257 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1886264 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1886271..1886282 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(1886289..1886308) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1886294) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1886340..1886347 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1886361..1886380 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1886363 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1886405..1887421 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 1886405..1887421 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 1887408 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 1887470..1887479 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1887492..1887507 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1887496 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1887531..1888292 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 1887531..1888292 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 1888200 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 1888288 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1888320..1888520) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(1888336..1888461) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(1888336..1888461) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(1888363) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1888454..1888486) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(1888454..1888486) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(1888514..1888533) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1888520) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1888546..1888553) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1888568..1889491) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(1888568..1889491) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(1889517..1889536) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1889530) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1889550..1889555) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1889629..1889636 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1889650..1889669 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1889652..1889717 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 1889652 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 1889718..1891187 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 1889718..1891187 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 1891170 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 1891195..1891234 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(1891207,1891210) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(1891215,1891216) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(1891227,1891228) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 1891236 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1891310..1892719) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(1891310..1892719) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(1891327) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(1891400) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(1892783..1892801) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1892785) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1892829..1894073) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(1892829..1894073) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(1894074..1894348) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 1894094..1894101 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1894115..1894134 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1894115 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 1894146..1894433 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 1894146..1894433 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(1894330..1894349) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(1894350) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(1894365..1894368) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 1894464..1895291 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 1894464..1895291 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 1895108 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 1895284 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1895296..1896216) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(1895339) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1895409..1895415 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1895429..1895447 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1895438 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 1895471..1896199 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 1895471..1896199 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(1896240..1897355) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(1896240..1897355) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(1896261) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(1897373..1898896) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(1897373..1898896) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(1898479..1898498) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1898501) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1898513..1898517) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1898889..1899311) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(1898889..1899311) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 1899340..1899347 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1899361..1899380 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1899375..1899528 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 1899375 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 1899485 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(1899513..1900043) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(1899513..1900043) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 1899530..1900165 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(1900060..1900071) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1900067) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1900086..1900092) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1900095..1901063) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(1900095..1901063) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(1900111) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1901134..1901856) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(1901134..1901856) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(1901145) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(1901849..1902508) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(1901849..1902508) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(1902509..1902588) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(1902589..1903356) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(1902589..1903356) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(1903406..1903425) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1903421) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1903440..1903447) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1903624..1904061) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(1903624..1904061) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(1903633) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1904085..1904104) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(1904106) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(1904119..1904126) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 1904159..1904165 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1904178 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1904180..1904198 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1904222..1905115 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 1904222..1905115 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 1905148..1905155 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1905171..1905190 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1905179 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 1905216..1906385 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 1905216..1906385 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 1906368 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 1906458..1907294 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 1906458..1907294 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 1907292 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1907356) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1907356..1908630) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(1907356..1908630) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(1908653..1909636) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(1908653..1909636) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(1909650..1910642) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(1909650..1910642) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(1910664..1912088) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(1910664..1912088) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(1912109..1913200) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(1912109..1913200) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(1913219..1914313) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(1913219..1914313) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(1914325..1915224) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(1914325..1915224) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(1915260..1915279) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1915265) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1915267..1915348) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(1915349..1917427) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(1915349..1917427) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(1917487..1917506) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1917504) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1917514..1917521 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1917523..1917526) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1917535..1917554 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1917542 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 1917580..1917816 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 1917580..1917816 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 1917807 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1917858..1918763) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(1917858..1918763) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(1917861) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1918781..1920199) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(1918781..1920199) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(1919076..1919095) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1919093) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1920214..1921332) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(1920214..1921332) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(1921366..1922505) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(1921366..1922505) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(1922533..1923396) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(1922533..1923396) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(1923421..1924602) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(1923421..1924602) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(1924182) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(1924289..1924295) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1924292) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(1924516..1924616) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1924556) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1924649..1924667) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1924667) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1924683..1924688) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1924729..1925460) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(1924729..1925460) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(1924736) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1925483..1925502) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1925494) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1925517..1925520) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1925539..1926159) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(1925539..1926159) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(1926174..1926467) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(1926174..1926467) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(1926487..1926506) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1926493) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1926521..1926528) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1926723..1926730 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1926744..1926763 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1926761..1926966 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 1926761 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 1926775..1926927 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 1926775..1926927 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 1926935..1926942 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1926957..1926976 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1926968 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 1927000..1928118 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 1927000..1928118 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 1928103 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(1928145..1928315) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(1928188) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1928299..1928314) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1928315) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1928317..1928445) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(1928326..1928335) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1928444..1928463) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1928467) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1928477..1928485) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1928577) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1928583..1929386) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(1928583..1929386) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(1929429..1929447) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1929435) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1929437..1929589) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(1929458..1929466) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1929585..1929604) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1929597) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1929616..1929623) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 1929631..1929632 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_005" CDS complement(1929692..1931422) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(1929692..1931422) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(1929707) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1931459..1931908) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(1931459..1931908) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(1931909..1931994) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(1932006..1932851) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(1932006..1932851) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(1932039) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(1932848..1934749) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(1932848..1934749) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 1933957..1933963 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1933978..1933989 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1933986 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1934750..1934878) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(1934873..1934892) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1934878) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1934907..1934913) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1934924..1935814) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(1934924..1935814) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(1935804..1936058) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(1935804..1936058) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(1936055..1937401) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(1936055..1937401) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(1937402..1937538) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(1937539..1938390) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(1937539..1938390) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(1938402..1938797) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(1938402..1938797) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(1938840..1938859) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1938859) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1938861..1939023) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(1939061..1939468) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(1939061..1939468) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(1939068) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(1939489..1940841) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(1939489..1940841) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(1940370..1940389) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(1940377) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(1940404..1940410) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(1940853..1941332) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(1940853..1941332) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(1941391..1941410) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1941402) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1941424..1941431) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1941488..1942144) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(1941488..1942144) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(1941495) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(1942145..1942834) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(1942145..1942834) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(1942827..1943447) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(1942827..1943447) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(1943153..1943171) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1943171) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1943187..1943192) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1943461..1944660) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(1943461..1944660) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(1944679..1945080) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(1944679..1945080) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(1945087..1945293) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(1945087..1945293) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(1945316..1945831) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(1945316..1945831) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(1945825..1946748) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(1945825..1946748) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(1946749..1946823) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(1946824..1947105) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(1946824..1947105) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(1947125..1947143) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(1947148) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(1947159..1947164) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(1947250..1947807) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(1947250..1947807) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(1947262) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1947832..1948893) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(1947832..1948893) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(1948890..1949336) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(1948890..1949336) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(1949385..1949404) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949401) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1949417..1949424) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1949423..1949959) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(1949423..1949959) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(1949972..1949983) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(1949981) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(1949997..1950003) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 1950029..1950035 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1950048 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1950050..1950068 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1950105..1950108 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1950123..1950142 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1950134 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 1950186..1951142 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 1950186..1951142 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 1951182..1951577 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 1951182..1951577 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 1951460..1951560 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1951520 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1951563 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1951574..1952449) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(1951574..1952449) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(1952476..1952494) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1952493) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1952510..1952515) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1952575..1953003) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(1952575..1953003) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(1952602) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1953038..1953057) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953046) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1953073..1953077) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1953103..1953939) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(1953103..1953939) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(1953963..1953982) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953974) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1953976..1954520) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(1953996..1954003) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1954020..1954025 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1954039..1954058 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1954039 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 1954050..1954129 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 1954130..1954510 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 1954130..1954510 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 1954446 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1954490 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1954545..1956011) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(1954545..1956011) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(1954565) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(1956004..1957350) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(1956004..1957350) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(1957380..1958468) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(1957380..1958468) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(1958542..1958741) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(1958542..1958741) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(1958592) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(1958742..1958812) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 1958745..1958750 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1958766..1958784 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1958770 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 1958780..1958909 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(1958798..1958817) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(1958812) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(1958831..1958838) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 1958910..1960583 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 1958910..1960583 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 1960604..1961398 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 1960604..1961398 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 1960934..1960935 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1960940 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 1961422..1961425 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1961441..1961460 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1961442..1961580 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 1961442 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 1961581..1961754 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 1961581..1961754 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 1961739..1961743 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1961756..1961775 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1961756 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 1961788..1962123 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 1961788..1962123 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 1962100 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 1962190 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts complement(1962222) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(1962239,1962246) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27" N_region 1962240..1962245 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27" promotor_-35 1962315..1962321 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1962322 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1962335..1962346 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1962365..1962691 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 1962365..1962691 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(1962508..1962732) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(1962551) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1962673 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1962733..1962912) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(1962733..1962912) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(1962931..1962949) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1962946) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1962964..1962970) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1962983..1963357) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(1962983..1963357) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(1963358..1963741) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(1963358..1963741) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(1963767..1964114) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(1963767..1964114) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(1964098..1964529) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(1964098..1964529) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(1964519..1964815) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(1964519..1964815) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(1964829..1965800) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(1964829..1965800) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(1965853..1966923) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(1965853..1966923) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(1966941..1966960) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1966957) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1966974..1966981) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1967106..1967334) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(1967147) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1967335..1968288) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(1967335..1968288) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(1968312..1968331) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1968333) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1968345..1968351) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1968371..1968377 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1968392..1968410 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1968410 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 1968431..1969759 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 1968431..1969759 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 1969760..1970734 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(1969812..1970648) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(1969812..1970648) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(1970649..1970833) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 1970735..1970805 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 1970735..1970805 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(1970872..1971252) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(1970872..1971252) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(1970878) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1971281..1971299) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1971300) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1971314..1971320) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1971339..1971344 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 1971360..1971378 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 1971369 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 1971419..1971426 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 1971441 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 1971442..1971461 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 1971484..1971729 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 1971484..1971729 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 1971626 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 1971715 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 1971760..1972515 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(1971769..1972404) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(1971769..1972404) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(1971794) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1972426..1972445) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1972443) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1972459..1972466) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1972483..1972490 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1972505..1972524 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1972517 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1972537) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1972539..1972553) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1972561..1972565) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1972561..1972734 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 1972561..1972734 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 1972722 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(1972766..1973080) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(1972766..1973080) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 1972767..1973834 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(1972780) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1973083..1974144) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(1973083..1974144) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(1974206..1975336) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(1974206..1975336) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(1975344..1975362) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1975376) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1975378..1975383) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1975419..1977335) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(1975419..1977335) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(1975446) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 1976451..1976457 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1976470..1977499 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 1976470 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1976473..1976491 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(1977336..1977402) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(1977396..1977415) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1977402) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1977430..1977437) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1977452..1978417) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(1977452..1978417) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(1978428..1978643) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(1978428..1978643) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(1978644..1978752) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(1978753..1980276) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(1978753..1980276) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(1980294..1980313) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1980307) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1980328..1980335) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1980366..1980539) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(1980366..1980539) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(1980393) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1980555..1980566) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1980567) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1980580..1980586) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1980606..1981169) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(1980606..1981169) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(1981170..1981253) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(1981254..1981403) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(1981254..1981403) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(1981300) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1981440..1981459) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1981450) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1981475..1981478) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1981487..1982566) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(1981487..1982566) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(1982563..1983033) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(1982563..1983033) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 1982978..1982986 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1983000..1983008 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1983001..1983174 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 1983002 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1983069..1983088) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1983081) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1983100..1983107) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1983146..1983150 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1983166..1983185 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1983176 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1983213..1983566 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 1983213..1983566 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 1983563..1984027 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 1983563..1984027 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 1984013 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1984056..1984838) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(1984056..1984838) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(1984067) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1984849..1985658) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(1984849..1985658) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(1985679..1986563) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(1985679..1986563) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(1986563..1987492) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(1986563..1987492) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(1987561..1988463) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(1987561..1988463) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(1988518) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1988526..1988542) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1988553..1988555) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(1988572,1988574) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(1988618..1990768) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(1988618..1990768) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(1988628) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1989362..1989380) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1989370) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1989396..1989402) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1990057..1990076) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1990074) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1990090..1990099) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1990818..1990837) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1990823) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1990853..1990857) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1990882..1992174) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(1990882..1992174) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(1992197..1992208) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1992208) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1992222..1992228) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1992281..1992889) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(1992281..1992889) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(1992296) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1992941..1992960) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1992952) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1992954..1993022) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(1992975..1992982) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1993013..1993031) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1993022) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1993046..1993052) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1993068..1993550) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(1993068..1993550) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(1993551..1993843) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 1993593..1993599 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1993614..1993633 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1993627 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 1993660..1994427 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 1993660..1994427 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(1993841..1993859) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(1993843) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(1993845..1994781) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(1993873..1993879) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 1994428..1994858 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 1994815 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1994826) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(1994843..1995271) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(1994843..1995271) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 1995267..1995271 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 1995281..1995295 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 1995290 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(1995294..1995313) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(1995317) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(1995328..1995335) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 1995486..1995491 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1995507..1995525 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1995519 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 1995548..1995847 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 1995548..1995847 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 1995860..1995867 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1995882..1995901 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1995893..1995969 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 1995893 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 1995970..1997103 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 1995970..1997103 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 1997084 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1997129..1997518) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(1997129..1997518) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(1997155) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1997549..1997560) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1997553) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1997574..1997580) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1997593..1997600 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1997611..1997630 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1997612 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 1997651..1998232 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 1997651..1998232 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 1998230 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 1998275..1998883 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(1998275..1998712) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(1998275..1998712) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(1998279) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1998713..1998807) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(1998803..1998822) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1998807) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1998837..1998844) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1998850..1999731) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(1998850..1999731) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 1999727..1999732 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1999748..1999766 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1999764 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1999769..1999788) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1999775) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1999777..2000104) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 1999793..1999802 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1999809 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1999815..1999834 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1999847..2000101 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 1999847..2000101 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2000088 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2000128..2001021) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2000128..2001021) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2000133..2000934 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2000149) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2001031..2002347) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2001031..2002347) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2002383..2002402) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2002394) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2002418..2002422) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2002451..2002460 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2002472 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2002474..2002493 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2002516..2003259 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2002516..2003259 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2003241 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2003263..2003270 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2003284..2003303 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2003286..2003381 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2003286 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2003382..2004326 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2003382..2004326 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2004297 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2004349..2005470) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2004349..2005470) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2004374) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2005463..2006113) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2005463..2006113) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2006114..2006222) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2006210..2006229) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2006222) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2006224..2006337) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2006245..2006249) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2006370..2006732) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2006370..2006732) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2006382) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2006728..2006732 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2006740..2006754 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2006761 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2006769..2006788) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2006771) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2006773..2006894) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2006800..2006807) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2006883..2006902) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2006891..2006910 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2006894) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2006896..2007035) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2006897..2007001 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2006897 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2006916..2006922) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2006965..2006972 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2006986..2007005 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2007003..2009152 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2007003 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2007061..2008176) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2007061..2008176) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2007080) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2008177..2008374) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2008375..2010186) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2008375..2010186) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2009781..2009787 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2009797 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2009799..2009818 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2009826..2010122 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2009826..2010122 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2010220..2010714) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2010220..2010714) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2010687..2010705) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2010698) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2010715..2010828) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2010717..2010725) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2010723..2010728 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2010744..2010762 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2010759 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2010813..2010831) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2010828) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2010830..2010907) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2010847..2010852) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2010873..2010892) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2010907) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2010908..2010911) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2010968..2011780) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2010968..2011780) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2011806..2012444) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2011806..2012444) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2012445..2012576) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2012570..2012589) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2012577..2014616) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2012577..2014616) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2012579) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2012604..2012611) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2012623) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2012689) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2014609..2015496) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2014609..2015496) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2015579..2015753) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2015579..2015753) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2015613) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2015728..2015733 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2015749..2015767 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2015757..2015776) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2015759..2017171 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2015759 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2015769) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2015791..2015798) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2015793..2016560) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2015793..2016560) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2016597..2016740) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2016597..2016740) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2016741..2016887) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2016888..2017793) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2016888..2017793) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2017774..2018184) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2017774..2018184) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2018222..2018241) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2018233) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2018235..2018302) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2018256..2018259) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2018303..2018674) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2018303..2018674) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2018655..2019128) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2018655..2019128) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2019129..2021264) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2019129..2021264) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2021108..2021113 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2021128 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2021129..2021147 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2021343..2022302) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2021343..2022302) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2021358) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2022299..2023495) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2022299..2023495) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2022366..2022385) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2022371) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2022399..2022406) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2022446..2022464) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2022458) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2022479..2022485) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2022673) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2022687..2022698) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2022713..2022719) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2023514..2023795) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2023514..2023795) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2023852..2024271) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2023852..2024271) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2023866) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2024296..2025291) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2024296..2025291) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2025313..2026626) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2025313..2026626) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2026662..2026677) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2026679) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2026690..2026699) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2026757..2027203) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2026757..2027203) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2026770) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2026968) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2027218..2027391) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2027218..2027391) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2027327..2027331 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2027332 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2027452..2027471) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2027467) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2027485..2027492) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2027510..2027515 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2027530 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2027531..2027549 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2027564..2028487 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2027564..2028487 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2028524..2029879) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2028524..2029879) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2028530) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2029879..2030649) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2029879..2030649) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2030672..2031607) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2030672..2031607) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2031632..2032759) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2031632..2032759) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2032676..2032679 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2032687 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2032760..2032937) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2032799..2032889 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2032799..2032889 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2032959..2034794) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2032959..2034794) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2032982) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2034818..2035381) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2034818..2035381) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2035382..2035452) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2035453..2036484) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2035453..2036484) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2036525..2036544) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2036538) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2036559..2036566) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2036565..2037704) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2036565..2037704) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2037577..2037588) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2037581) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2037602..2037608) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2037757..2039595) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2037757..2039595) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2037779) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2039630..2039649) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2039647) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2039665..2039669) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2039729..2040067) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2039729..2040067) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2039735) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2040084..2041289) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2040084..2041289) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2041309..2041327) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2041321) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2041343..2041348) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2041352..2042458) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2041352..2042458) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2042486..2042497) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2042493) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2042512..2042518) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2042557..2042560 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2042573 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2042576..2042595 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2042587..2042661 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2042662..2042928 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2042662..2042928 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2042917 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2042943..2043986) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2042943..2043986) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2042988) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2044015..2044034) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2044026..2044175) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2044026..2044175) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2044027) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2044048..2044052) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2044050..2044389) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2044093) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2044162..2044168 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2044182..2044201 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2044183 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2044216..2044350 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2044216..2044350 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2044344 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2044390..2046720) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2044390..2046720) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2044407..2044426) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2044423) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2044440..2044449) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2046724..2047293) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2046724..2047293) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2047320..2047339) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2047330) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2047354..2047361) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2047360..2047977) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2047360..2047977) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2047998..2048003 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2048015 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2048019..2048037 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2048038..2048052) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2048040) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2048042..2048889) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2048061..2048065) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2048061..2048882 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2048061..2048882 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2048877..2048896) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2048883..2048963 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2048890) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2048910..2048917) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2048923 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2048948..2049691) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2048948..2049691) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2048978) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2049688..2050044) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2049688..2050044) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2050062..2050622) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2050062..2050622) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2050612..2051181) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2050612..2051181) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2051193..2051483) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2051193..2051483) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2051477..2052319) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2051477..2052319) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2052311 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2052337..2053437) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2052337..2053437) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2053441..2053959) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2053441..2053959) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2053869..2053886) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2053883) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2053902..2053905) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2053960..2054521) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2053993) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2054184..2054191 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2054202..2054302 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2054202..2054221 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2054202 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2054252..2054510) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2054252..2054510) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2054303..2054461 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2054303..2054461 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2054462..2054708 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2054509..2054528) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2054520) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2054544..2054548) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2054572..2054719) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2054609) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2054665 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2054710..>2054787 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2054714..2054733) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2054719) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2054746..2054755) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2054787,2054789) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" N_region 2054788 /note="inserted C residue" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" S_feature <2054789..2055231 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" CDS complement(2054802..2055218) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2054802..2055218) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2055264..2056562) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2055264..2056562) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2056549..2057244) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2056549..2057244) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2057310..2057327) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2057319) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2057405..2057411 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2057418..2057436 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2057433 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2057512..2058729 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2057512..2058729 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2057971..2057978 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2057993..2058012 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2058009 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2058648..2058896 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2058648..2058896 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2058825..2059872) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2059241..2059798 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2059241..2059798 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2059799..2059921 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2059874..2060288) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2059917) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2060289..2060813) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2060289..2060813) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2060661..2060668 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2060679..2060698 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2060693 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2060814..2060901) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2060896..2060915) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2060901) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2060903..>2061039) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2060930..2060937) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2061039,2061046) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2061040..2061045 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2061098..2061628) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2061098..2061628) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2061674..2061693) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2061697) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2061707..2061714) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2061763..2062743 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2061763..2062743 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2063017..2064333) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2063017..2064333) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2064334..2064447) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2064448..2065317) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2064448..2065317) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2065340..2065359) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2065357) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2065374..2065379) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2065424..2065425) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2065432) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2065462..2065463) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2065462..2066565 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2065462..2066565 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2066455..2066474 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2066461 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2066812) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2066838..2067671) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2066838..2067671) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2067701..2067720) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2067710) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2067876..2067880 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2067891..2068113 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2067891 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2067895..2067914 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2068114..2068377 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2068114..2068377 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2068365 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2068514..2069329 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2068514..2069329 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2069664..2069736) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2069707) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2069737..2070093) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2069737..2070093) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2070146..2070505) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2070146..2070505) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2070598..2070617) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2070608) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2070777..2070878) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2070777..2070878) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2070918..2071020) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2070960) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2071021..2071407) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2071021..2071407) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2071449..2071465) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2071465) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2071598..2071604 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2071619..2071630 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2071619 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2071656..2071901 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2071656..2071901 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2071919..2072287 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2071919..2072287 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2072306..2073442 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2072306..2073442 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2073461..2073658 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2073461..2073658 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2073674..2073973 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2073674..2073973 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2073964 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2074236..2074658) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2074236..2074658) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2074656..2074659 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2074675..2074694 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2074690..2074840 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2074690 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2074693..2074712) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2074700) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2074726..2074733) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2074809..2074828) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2074817) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2074841..2075035 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2074841..2075035 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2074843..2074850) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2075053..2075060 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2075076..2075095 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2075080 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2075081..2075165 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2075166..2076215 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2075166..2076215 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2076283..2076290 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2076305..2076324 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2076318 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2076346..2076855 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2076346..2076855 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2076824 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2076869..2077974 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2076897..2078930) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2076897..2078930) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2076922) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2078839..2079006) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2078839..2079006) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2078931..2079086) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2079087..2079914) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2079087..2079914) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2079935..2080744) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2079935..2080744) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2080761..2081249) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2080761..2081249) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2081249..2081689) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2081249..2081689) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2081686 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2081726..2081744) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2081730) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2081879..2084686) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2081879..2084686) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2084902..2084921) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2084908) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2085233..2085373 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2085233..2085373 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2085354..2085373 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2085364 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2085412..2086800 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2085412..2086800 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2086789 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2086822..2086895) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2086864) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2086896..2087528) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2086896..2087528) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2086952) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2087582..2087601) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2087593) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2087607..2087613 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2087616..2087623) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2087627..2087646 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2087632 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2087681..2088508 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2087681..2088508 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2088504 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2088621..2088630 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2088643..2088658 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2088648 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2088704..2089204 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2088704..2089204 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2089204..2090061 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2089204..2090061 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2090079..2090090) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2090098) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2090105..2090111) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2090172..2092076 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2090172..2092076 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2092157..2092163 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2092179..2092197 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2092185 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2092210..2092500 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2092210..2092500 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2092501..2092616 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2092598..2092605 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2092618..2092743 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2092618 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2092619..2092637 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2092637..2092737 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2092637..2092737 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2092700 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2092744..2095908) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2092744..2095908) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2092760) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2093894..2093903 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2093917..2093936 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2093938 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2095924..2096508) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2095924..2096508) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2096731..2097273) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2096731..2097273) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2097274..2097359) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2097357..2097372) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2097359) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2097385..2097394) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2097428..2097644) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2097462..2097620) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2097462..2097620) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2097471) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2097642..2097661) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2097644) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2097646..2097776) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2097675..2097684) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2097777..2097926) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2097777..2097926) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2097920 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2097927..2098017) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2098019..2098238) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2098062) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2098184 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2098217..2098236) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2098238) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2098240..2098315) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2098251..2098258) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2098316..2099116) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2098316..2099116) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2099185..2099338) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2099228) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2099329..2099348) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2099338) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2099363..2099369) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2099379..2099747) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2099379..2099747) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2099748..2099844) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2099830..2099849) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2099834..2099837 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2099850) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2099853..2099872 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2099855 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2099856..2100062 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2099865..2099869) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2100063..2103005 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2100063..2103005 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2103024..2103506 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2103024..2103506 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2103486 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2103542..2103772) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2103542..2103772) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2103562) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2103773..2103854) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2103855..2104994) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2103855..2104994) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2104996..2105919) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2104996..2105919) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2105912) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2105920..2105983) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2105984..2106679) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2105984..2106679) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2106419..2106438) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2106437) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2106451..2106460) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2106700..2107341) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2106700..2107341) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2106908..2106927) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2106927) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2106944..2106947) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2107393..2107402 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2107399..2107418) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2107405) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2107415..2107434 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2107424..2107488 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2107424 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2107434..2107437) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2107469..2107476 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2107490 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2107492..2107509 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2107534..2107737 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2107534..2107737 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2107744 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2107774..2108475) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2107774..2108475) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2107786) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2108540..2110294) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2108540..2110294) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2108568..2108587) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2108578) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2109609..2109624) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2109612) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2109637..2109646) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2109840..2109858) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2109854) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2109873..2109880 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2109873..2109878) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2109895..2109914 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2109900 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2110348..2110821) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2110348..2110821) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2110355) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2110822..2110954) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2110936..2110955) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2110954) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2110956..2111064) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2110969..2110976) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2111057..2111076) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2111064) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2111072..2111707) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2111072..2111707) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2111092..2111096) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2111202..2111207 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2111223..2111241 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2111230 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2111714..2112982) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2111714..2112982) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2113001..2113930) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2113001..2113930) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2113936..2114589) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2113936..2114589) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2114590..2114694) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2114676..2114695) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2114694) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2114711..2114715) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2114741..2115823) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2114741..2115823) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2114775) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2115839..2115858) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2115859) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2115873..2115876) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2115949) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2115954..2116235) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2115954..2116235) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2116014) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2116253..2116669) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2116253..2116669) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2116501..2116519) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2116520) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2116535..2116540) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2116677..2116943) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2116677..2116943) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2116831..2116839 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2116854..2116873 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2116862..2118051 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2116862 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2116944..2117004) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2116998..2117017) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2117004) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2117028..2119664) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2117028..2119664) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2117031..2117038) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2119430..2119448) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119446) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119462..2119469) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2119665..2119743) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2119744..2119951) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2119744..2119951) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2119959..2119978) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2119974) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2119993..2120000) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2119995..2121056) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2119995..2121056) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2120965..2120970 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2120976..2121211 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2120977 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2120986..2121004 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2121073..2121084) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2121074) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2121098..2121104) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2121212..2121940 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2121212..2121940 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2121668) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2121962..2122783 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2121962..2122783 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2122844..2123494 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2122844..2123494 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2123511..2124167 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2123511..2124167 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2124166 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2124202..2124333) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2124202..2124333) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2124220) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2124355..2124546) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2124355..2124546) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2124558..2125082) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2124558..2125082) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2124669) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2124673..2124684) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2124699..2124705) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2125053..2125064) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2125059) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2125079..2125085) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2125140..2127536) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2125140..2127536) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2125166) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2125386..2125392 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2125400 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2125407..2125418 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2125420..2125769 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2125521) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2127561..2128181) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2127561..2128181) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2128267..2129382) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2128267..2129382) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2128268) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2129413..2130552) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2129413..2130552) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2130119..2130138) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2130131) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2130152..2130159) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2130571..2130987) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2130571..2130987) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2130988..2131085) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2131070..2131089) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2131085) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2131105..2131108) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2131133..2131140 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2131154..2131173 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2131162 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2131190..2132455 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2131190..2132455 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2132454 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2132497..2133261) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2132497..2133261) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2132515) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2133345..2133545) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2133345..2133545) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2133363) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2133532 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2133533..2133542 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2133543..2133562) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2133554) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2133575..2133582) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2133597..2135375) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2133597..2135375) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2135389..2136663) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2135389..2136663) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2136753..2136985) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2136753..2136985) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2136783) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2136995..2136998 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2137009..2137028) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2137013..2137032 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2137015..2137299 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2137015 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2137028) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2137043..2137050) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2137045..2137215) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2137045..2137215) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2137246..2137257) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2137263) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2137272..2137278) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2137275..2137282 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2137296..2137314 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2137301 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2137348..2138904 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2137348..2138904 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2138883 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2138931..2139329) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2138931..2139329) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2138939) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2139383..2141587) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2139383..2141587) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2141616..2141635) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2141623) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2141625..2141715) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2141650..2141657) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2141679 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2141755..2142267) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2141755..2142267) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2141760) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2142273..2144633) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2142273..2144633) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2142737..2142756) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2142745) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2142770..2142779) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2144647..2144666) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2144658) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2144681..2144687) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2144700..2145023) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2144700..2145023) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2145044..2145062) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2145055) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2145077..2145083) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2145099..2145596) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2145099..2145596) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2145597..2145672) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2145666..2145685) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2145672) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2145699..2145706) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2145754..2147967) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2145754..2147967) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2145759) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2147526..2147531 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2147545..2147564 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2147553 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2148006..2148302) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2148006..2148302) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2148213 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2148303..2148381) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2148343..2148348 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2148365..2148383 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2148367..2148386) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2148367 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2148381) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2148383..2149301) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2148401..2148404) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2148418..2149974 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2148418..2149974 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2149287..2149305) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2149301) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2149317..2149325) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2149975..2150739 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2149978..2150634) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2149978..2150634) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2150653..2150664) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2150665) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2150678..2150684) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2150717..2150722 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2150738..2150756 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2150741 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2150769..2151221 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2150769..2151221 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2151205 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2151260) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2151278..2151544) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2151278..2151544) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2151581..2152726) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2151581..2152726) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2151633) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2151677) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2151679..2151698) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2151713..2151718) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2152753..2153781) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2152753..2153781) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2153811..2154011) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2153811..2154011) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2154004..2155008) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2154004..2155008) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2155019..2155624) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2155019..2155624) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2155643..2155662) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2155659) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2155661..2155762) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2155673..2155679) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2155763..2156275) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2155763..2156275) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2156304..2156315) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2156319) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2156323..2157630) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2156323..2157630) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2156330..2156336) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2157584) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2157654..2157672) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2157669) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2157687..2157693) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2157701..2158726) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2157701..2158726) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2158763..2158782) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2158783) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2158797..2158804) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2158852..2158859 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2158873..2158892 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2158881 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2158913..2158918 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2158927 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2158934..2158952 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2158964..2159611 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2158964..2159611 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2159286..2159619) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2159590 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2159621..2159818) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2159657..2159779) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2159657..2159779) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2159664) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2159827) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2159828..2159845) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2159852..2159859) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2159864..2160154 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2159864..2160154 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2159875..2159894 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2159875..2160022 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2159875 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2160161..2160301 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2160161..2160301 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2160290 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2160350..2160356 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2160364..2160464 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2160371..2160389 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2160372 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2160424 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2160465..2161919 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2160465..2161919 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2161920 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2161960..2162682) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2161960..2162682) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2161965..2162386 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2161976) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2162705..2162724) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2162722) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2162738..2162745) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2162785..2163381) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2162785..2163381) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2162800) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2163424..2163435) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2163426) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2163428..2163492) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2163450..2163456) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2163529..2164692) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2163529..2164692) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2163537) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2164693..2164768) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2164744..2164762) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2164768) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2164778..2164783) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2164809..2165915) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2164809..2165915) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2165491..2165509) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2165516) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2165525..2165530) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2165827 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2165828..2165831 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2165902..2166771) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2165902..2166771) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2165996 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2166725..2168320) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2166725..2168320) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2168348..2168355 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2168348..2168367) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2168369 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2168371..2168390 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2168372) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2168382..2168389) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2168423..2169610 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2168423..2169610 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2168424..2168443) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2168442) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2168458..2168467) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2169325..2169330 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2169339 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2169341..2169360 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2169570..2170112 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2169570..2170112 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2170095 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2170137..2170994) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2170137..2170994) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2170140..2170849 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2170157) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2171011..2171454) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2171011..2171454) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2171515..2172801) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2171515..2172801) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2172835..2173413) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2172835..2173413) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2173414..2173479) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2173464..2173483) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2173479) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2173481..2173698) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2173491..2173613 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2173491..2173613 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2173497..2173504) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2173734..2174018) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2173734..2174018) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2173743) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2174031..2174369) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2174031..2174369) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2174372..2174680) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2174372..2174680) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2174694..2174769) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2174694..2174769) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2174781..2174800) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2174801) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2174814..2174821) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2174827..2175693) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2174827..2175693) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2175686..2176480) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2175686..2176480) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2176483 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2176489..2176589 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2176504..2176522) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2176515) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2176538..2176543) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2176549 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2176592 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2176627) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2176630..2177436) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2176630..2177436) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2177438..2178118) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2177438..2178118) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2178171..2178689) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2178171..2178689) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2178686..2179558) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2178686..2179558) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2179589..2180602) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2179589..2180602) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2180643) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2180655..2180673) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2180694..2181389) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2180694..2181389) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2181426..2181995) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2181426..2181995) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2181847..2181862) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2181856) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2181875..2181884) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2182034..2182053) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2182050) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2182067..2182073) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2182146) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2182148..2183146) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2182148..2183146) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2183193..2183212) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2183201) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2183224..2183231) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2183269) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2183280..2184026) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2183280..2184026) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2184054..2184073) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2184061) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2184088..2184095) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2184166..2185458) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2184166..2185458) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2184171) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2185459..2185517) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2185518..2188160) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2185518..2188160) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2188161..2188219) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2188220..2188442) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2188220..2188442) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2188263) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2188471..2188490) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2188483) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2188485..2188593) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2188505..2188510) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2188547..2188556 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2188569..2188588 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2188570 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2188586..2188600) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2188593) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2188608..2188612) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2188608..2188799 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2188608..2188799 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2188818..2189843) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2188818..2189843) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2188848) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2189876..2191603) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2189876..2191603) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2191205..2191208 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2191224..2191243 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2191230 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2191599..2191603 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2191612..2191626 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2191626 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2191641..2191659) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2191657) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2191675..2191680) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2191734..2193026) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2191734..2193026) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2191751) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2193056..2194030) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2193056..2194030) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2194027..2194815) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2194027..2194815) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2194805..2195749) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2194805..2195749) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2195782..2196612) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2195782..2196612) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2196620..2197987) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2196620..2197987) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2198051..2198070) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2198057) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2198059..2198148) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2198108..2198127 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2198116 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2198145..2198164) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2198148) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2198150..2198566) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2198175..2198183) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2198217..2198714 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2198217..2198714 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2198550..2198568) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2198566) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2198568..2198698) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2198584..2198590) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2198678..2198689) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2198698) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2198704..2198710) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2198736..2199323) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2198736..2199323) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2198764) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2199320..2201644) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2199320..2201644) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2201645..2201756) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2201741..2201760) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2201756) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2201774..2201781) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2201825..2203483) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2201825..2203483) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2201844) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2203527..2203545) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2203538) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2203561..2203566) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2203635..2204897) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2203635..2204897) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2203645) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2204898..2204987) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2204975..2204994) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2204987) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2204989..2205120) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2205006..2205013) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2205165) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2205169..2206443) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2205169..2206443) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2206444..2206633) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2206620..2206639) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2206633) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2206654..2206658) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2206671..2207675) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2206671..2207675) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2207700..2207719) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2207718) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2207731..2207738) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2207794..2208393) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2207794..2208393) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2207815) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2208406..2209824) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2208406..2209824) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2209713..2209717 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2209732..2209736 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2209732 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2209874..2210971) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2209874..2210971) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2210992..2212548) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2210992..2212548) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2211388..2211391 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2211404..2213845 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2211404 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2211406..2211425 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2212535..2213563) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2212535..2213563) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2213587..2214105) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2213587..2214105) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2213826..2213829 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2213845..2213849 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2213847 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2214102..2215826) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2214102..2215826) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2215827..2215947) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2215948..2216194) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2215948..2216194) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2215991) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2216195..2216321) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2216303..2216322) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2216321) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2216323..2216453) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2216337..2216344) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2216448..2216467) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2216457) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2216481..2216484) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2216579..2216588 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2216602..2216621 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2216604 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2216642..2216977 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2216642..2216977 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2216971 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2217058..2217065 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2217079..2217098 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2217081..2217145 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2217081 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2217146..2217601 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2217146..2217601 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2217709..2217715 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2217729..2217747 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2217736 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2217785..2218606 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2217785..2218606 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2218599 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2218663 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2218670..2218743) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2218670..2218743) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2218704) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2218780..2218799) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2218783) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2218813..2218820) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2218874..2219383) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2218874..2219383) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2218891) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2219399..2219995) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2219399..2219995) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2220008..2220745) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2220008..2220745) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2220827..2220846) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220843) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2220856..2221956) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2220856..2221956) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2220861..2220866) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2220873) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2221979..2221997) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2221995) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2222012..2222017) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2222071..2222889) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2222071..2222889) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2222083) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2222897..2223337) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2222897..2223337) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2223380..2223399) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2223389) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2223391..2223533) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2223415..2223419) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2223578) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2223581..2223805) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2223581..2223805) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2223854 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2223856..2223874 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2223863..2223882) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2223883) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2223896..2223905) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2223921..2224364) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2223921..2224364) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2224425..2225186) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2224425..2225186) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2224433) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2225189..2226949) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2225189..2226949) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2226983..2227591) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2226983..2227591) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2227361..2227368 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2227381..2227400 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2227383 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2227592..2227687) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2227677..2227696) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2227687) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2227689..2228310) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2227711..2227718) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2227826..2227830 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2227840..2227940 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2227847..2227866 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2227856 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2227884..2228330 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2227884..2228330 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2227900 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2228318 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2228356) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2228374..2229600) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2228374..2228865) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2228374..2229600) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2228374..2228865) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2229714) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2229726..2229905) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2229726..2229905) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2229758) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2229930..2229949) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2229937) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2229962..2229969) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2229970..2231742) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2229970..2231742) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2231769..2231788) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2231783) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2231802..2231809) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2231872) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2231878..2232192) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2231878..2232192) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2232218..2232237) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2232232) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2232234..2232443) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2232253..2232255) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2232337..2232447) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2232337..2232447) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2232433..2232451) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2232443) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2232466..2232472) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2232515..2234002) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2232515..2234002) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2234003..2234115) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2234096..2234115) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2234115) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2234130..2234137) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2234219..2235196) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2234219..2235196) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2234227) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2235232..2236005) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2235232..2236005) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2236020..2236796) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2236020..2236796) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2236085 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2236811..2237395) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2236811..2237395) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2237437..2237456) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2237437) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2237469..2237476) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2237500..2239182) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2237500..2239182) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2239211..2239230) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2239219) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2239307) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2239371..2239775) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2239371..2239775) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2239373) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2239790..2242147) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2239790..2242147) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2242168..2243880) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2242168..2243880) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2243881..2243953) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2243954..2244487) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2243954..2244487) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2244494..2244751) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2244494..2244751) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2244778..2244797) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2244794) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2244809..2244816) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2244834..2244853 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2244841 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2244885..2245826 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2244885..2245826 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2245558..2245577) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2245573) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2245591..2245598) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2245809 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2245841) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2245862..2248276) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2245862..2248276) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2245885) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2248292..2249326) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2248292..2249326) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2249327..2249647) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2249408..2249614 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2249408..2249614 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2249637..2249901 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2249637 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2249642..2249661) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2249644..2249658 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2249647) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2249676..2249679) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2249681..2250427) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2249681..2250427) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2250454..2250473) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2250460..2250466 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2250467) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2250480..2250491 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2250487..2250493) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2250494 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2250546..2250761 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2250546..2250761 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2250743..2252155) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2250772..2250779 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2250795..2250814 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2250803 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2250830..2251936 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2250830..2251936 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2251972..2251975 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2251991..2252010 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2251995 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2252039..2253451 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2252039..2253451 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2252141..2252160) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2252155) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2252173..2252182) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2253448..2254782 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2253448..2254782 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2254481,2254483) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2254780 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2254819) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2254821..2255063) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2254821..2255063) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2255064..2255235) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2255123..2255293) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2255123..2255293) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2255236..2257032) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2255236..2257032) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2255338..2255356) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255356) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2255368..2255376) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2257029 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2257057..2257076) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2257067) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2257091..2257097) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2257127..2257183) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2257151) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2257184..2258686) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2257184..2258686) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2258557) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2258661..2258761) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2258701) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2258705..2259550) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2258705..2259550) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2259551..2260492) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2259551..2260492) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2260528..2261829) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2260528..2261829) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2261860..2263044) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2261860..2263044) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2263041..2263859) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2263041..2263859) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2263837..2264526) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2263837..2264526) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2264543..2266225) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2264543..2266225) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2266239..2267729) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2266239..2267729) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2267822..2267841) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267829) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2267831..2267906) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2267856..2267863) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2267907..2268878) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2267907..2268878) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2268879..2269007) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2268992..2269011) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2269007) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2269026..2269029) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2269075..2270160) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2269075..2270160) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2269089) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2270186..2270205) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2270209) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2270220..2270227) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2270278..2270287 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2270293 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2270299..2270314 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2270344..2270736 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2270344..2270736 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2270707 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2270752..2271058 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2270752..2271021) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2270752..2271021) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2270768) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2270937) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2271015 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2271078..2271437) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2271078..2271437) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2271091) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2271469..2271669) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2271469..2271669) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2271682..2272203) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2271682..2272203) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2272265..2272404) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2272265..2272404) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2272401..2272420) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2272411) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2272413..2272477) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2272434..2272441) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2272459..2272478) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2272477) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2272494..2272498) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2272596..2272603 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2272617..2272635 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2272617 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2272649..2273314 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2272649..2273314 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2273292 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2273346..2274041) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2273346..2274041) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2273368) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2273412) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2274063..2274503) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2274063..2274503) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2274525..2274544) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2274544) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2274560..2274563) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2274637..2275362) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2274637..2275362) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2274666) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2275340..2277121) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2275340..2277121) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2277205..2277208 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2277217..2277236) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2277222) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2277223..2277242 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2277230 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2277288..2278070 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2277288..2278070 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2278054 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2278104) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2278111..2280042) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2278111..2280042) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2280086..2280333) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2280086..2280333) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2280089..2280098) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2280089) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2280144) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2280344..2280363) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2280357) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2280359..2280439) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2280379..2280383) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2280440..2281285) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2280440..2281285) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2281305..2281323) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2281311) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2281339..2281344) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2281364..2282005) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2281364..2282005) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2282039..2282974) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2282039..2282974) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2283002..2284420) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2283002..2284420) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2284449..2284468) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2284457) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2284483..2284486) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2284535..2284993) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2284535..2284993) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2284554) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2284994..2285141) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2285132..2285151) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2285141) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2285143..2285221) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2285166..2285169) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2285266) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2285267..2285647) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2285267..2285647) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2285648..2285802) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2285782..2285801) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2285789 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2285790..2285809 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2285802) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2285816..2285822) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2285880..2285891) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2285886..2286908) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2285886..2286908) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2285887) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2285906..2285912) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2286952..2286971) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2286983) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2286984..2286991) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2287114..2287494) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2287114..2287494) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2287138) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2287495..2287625) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2287550..2287554 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2287570..2287589 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2287571..2287677 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2287571 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2287615..2287634) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2287625) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2287649..2287656) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2287678..2288868 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2287678..2288868 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2288500..2288518) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288516) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2288534..2288539) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2288892..2289734 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2288892..2289734 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2289507..2289512 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2289528..2289546 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2289529 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2289727 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2289767) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2289776..2290369) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2289776..2290369) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2290385..2291017) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2290385..2291017) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2291018..2291182) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2291183..2292013) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2291183..2292013) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2292036..2294678) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2292036..2294678) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2294733..2294752) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2294742) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2294766..2294773) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2294802..2294921) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2294845) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2294922..2296661) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2294922..2296661) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2296654..2297376) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2296654..2297376) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2297444..2297463) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297454) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2297456..2297556) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2297477..2297483) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2297588..2298526) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2297588..2298526) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2297601) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2298570..2299841) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2298570..2299841) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2299626..2299645) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2299638) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2299842..2299924) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2299924) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2299926..2300004) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2299926..2299945) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2299961..2299965) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2300005..2301123) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2300005..2301123) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2300618 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2300965..2300968 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2300973 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2301102 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2301124..2301330) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2301298..2301310 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2301309 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2301316..2301335) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2301330) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2301350..2301354) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2301450) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2301457..2301921) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2301457..2301921) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2301934..2301953) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2301948) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2301950..2303135) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2301950..2301955 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2301966..2301974) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2301970..2301988 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2301976 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2302018..2303133 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2302018..2303133 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2303104 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2303166..2303549) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2303166..2303549) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2303180) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2303550..2303641) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2303642..2305399) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2303642..2305399) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2305442..2306401) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2305442..2306401) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2306402..2306503) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2306492..2306511) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2306503) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2306527..2306531) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2306585..2307562) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2306585..2307562) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2306612) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2307547..2308419) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2307547..2308419) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2308381..2308386 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2308402..2308420 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2308406..2309580 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2308406 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2308420..2308503) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2308492..2308511) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2308503) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2308505..2308657) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2308527..2308531) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2308659..2308753) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2308702) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2308754..2309986) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2308754..2309986) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2309987..2310103) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2310091..2310110) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2310103) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2310123..2313470) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2310123..2313470) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2310124..2310131) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2311135..2311144 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2311156..2311171 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2311156 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2311344..2311363) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2311363) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2311377..2311384) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2313501..2313520) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2313519) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2313534..2313541) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2313559..2313564 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2313576 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2313580..2313598 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2313610..2313951 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2313610..2313951 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2313948..2314451 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2313948..2314451 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2314484..2314487 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2314502..2314521 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2314502 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2314553..2314744 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2314553..2314744 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2314554) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2314720 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2314762..2315703) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2314762..2315703) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2314765..2315136 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2314797) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2315105..2315114 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2315128..2315147 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2315138..2315532 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2315138 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2315494..2315500 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2315516..2315535 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2315534..2315833 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2315534 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2315722..2315741) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2315738) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2315740..2316154) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2315756..2315759) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2315834..2316136 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2315834..2316136 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2316137..2317932 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2316155..2317474) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2316155..2317474) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2317500..2317519) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2317521) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2317534..2317539) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2317650..2318552) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2317650..2318552) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2318571..2319821) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2318571..2319821) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2319839..2320531) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2319839..2320531) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2320578..2321906) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2320578..2321906) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2321903..2322184) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2321903..2322184) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2322199..2323203) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2322199..2323203) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2323200..2323979) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2323200..2323979) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2323976..2324683) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2323976..2324683) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2324713..2325432) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2324713..2325432) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2325258..2325265 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2325280..2325299 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2325280 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2325454..2326266) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2325454..2326266) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2326280..2327089) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2326280..2327089) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2327103..2327639) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2327103..2327639) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2327676..2327683 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2327694..2327713) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2327697..2327716 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2327700..2327791 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2327700 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2327710) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2327727..2327734) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2327792..2328718 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2327792..2328718 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2328194..2328723) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2328768) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2328769..2329452) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2328769..2329452) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2329453..2329514) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2329515..2330282) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2329515..2330282) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2330327..2330346) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2330349) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2330362..2330364) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2330409..2330645) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2330409..2330645) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2330494 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2330514) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2330605..2331990) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2330605..2331990) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2331987..2333198) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2331987..2333198) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2333199..2333276) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2333269..2333288) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2333275) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2333303..2333310) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2333368..2333880) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2333368..2333880) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2333386) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2333906..2333925) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2333914) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2333939..2333946) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2333965..2335152) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2333965..2335152) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2333980) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2335153..2335257) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2335242..2335261) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2335257) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2335259..2335388) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2335277..2335281) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2335325..2335528) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2335325..2335528) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2335386..2335397) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2335388) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2335412..2335418) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2335500..2336489) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2335500..2336489) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2335518) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2336550..2337053) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2336550..2337053) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2336556) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2336770..2336870 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2336830 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2337049 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2337076..2337095) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2337092) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2337109..2337116) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2337163..2337618) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2337163..2337618) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2337191) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2337632..2338312) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2337632..2338312) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2337724) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2337731..2337742) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2337757..2337763) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2338050) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2338325..2338343) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2338339) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2338358..2338363) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2338387..2338881) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2338387..2338881) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2338402) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2338894..2339901) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2338894..2339901) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2339925..2339940) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2339942) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2339944..2340023) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2339952..2339961) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2340001..2340020 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2340011 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2340016..2340035) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2340020..2340086 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2340023) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2340051..2340055) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2340087..2340890 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2340087..2340890 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2340820 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2340878 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2340922..2342511) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2340922..2342511) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2340931) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2342531..2344120) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2342531..2344120) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2344166..2344183) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2344171) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2344199..2344205) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2344298) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2344299..2344508) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2344299..2344508) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2344504..2344508 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2344508 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2344517..2344531 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2344529..2344540) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2344540) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2344555..2344561) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2344602..2345807) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2344602..2345807) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2345811..2346956) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2345811..2346956) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2346957..2348100) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2347043..2347050 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2347061..2347150 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2347061 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2347063..2347082 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2347151..2348488 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2347151..2348488 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2348086..2348105) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2348100) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2348120..2348127) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2348464 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2348583..2350271) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2348583..2350271) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2348584) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2350272..2350377) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2350354..2350362 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2350365..2350384) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2350373..2350392 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2350377) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2350377 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2350378..2350467 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2350379..2350938) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2350400..2350402) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2350468..2351274 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2350468..2351274 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2350942..2350961) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2350955) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2350973..2350980) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2351224..2351270) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2351246) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2351271..2351894) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2351271..2351894) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2351275..2351617 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2351595..2351602 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2351617..2351636 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2351619..2351762 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2351619 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2351734..2351738 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2351754..2351773 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2351764..2351894 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2351764 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2351896..2352020 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2351896 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2351910..2351928) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2351912..2351931 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2351928) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2351939..2351947) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2352021..2352512 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2352021..2352512 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2352491 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2352550..2354289) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2352550..2354289) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2352568) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2353763..2353770 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2353784..2353802 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2353787 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2353789..2354384 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2354319..2354338) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2354327) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2354329..2355162) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2354365..2354372 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2354386..2354583 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2354386..2354405 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2354386 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2354443..2354575 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2354443..2354575 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2354584..2355186 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2354584..2355186 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2355109 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2355164..2355383) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2355172 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2355207) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2355219 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2355264..2355437 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2355379..2355397) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2355391) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2355395 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2355412..2355418) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2355457..2356725) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2355457..2356725) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2355483) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2356749..2357022) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2356749..2357022) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2356770..2356913) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2356813) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2357020..2357039) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2357032) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2357052..2357059) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2357067..2358785) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2357067..2358785) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2358799..2358806 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2358813..2358832) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2358821..2358840 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2358827 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2358836) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2358846..2358852) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2358869..2358876 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2358890..2358909 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2358893 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2358946..2359578 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2358946..2359578 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2359151..2359159 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2359173..2359192 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2359179 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2359605..2360249 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2359605..2360249 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2360246..2361409 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2360246..2361409 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2361400 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2361420..2362148) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2361420..2362148) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2361456) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2362138..2362956) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2362138..2362956) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2363019..2364023) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2363019..2364023) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2363036) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2364058..2364077) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2364073) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2364075..2364183) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2364183..2364202) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2364183) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2364185..2364250) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2364216..2364222) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2364296) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2364299..2365375) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2364299..2365375) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2365416..2365435) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2365436) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2365438..2365538) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2365450..2365457) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2365472 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2365526..2365545) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2365538) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2365559..2365565) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2365611..2365937) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2365611..2365937) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2365620) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2365961..2366416) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2365961..2366416) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2366447..2366869) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2366447..2366869) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2366890..2366908) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2366903) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2366922..2366928) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2366942..2366960) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2366951) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2366971..2366979) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2367031..2368329) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2367031..2368329) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2367040) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2368354..2368373) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2368355) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2368357..2368553) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2368386..2368395) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2368536..2368555) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2368553) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2368567..2368573) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2368579..2371437) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2368579..2371437) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2371471..2371490) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2371481) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2371506..2371510) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2371580) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2371597..2372202) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2371597..2372202) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2372218..2373027) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2372218..2373027) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2373042..2373365) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2373042..2373365) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2373366..2373504) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2373404..2373520) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2373404..2373520) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2373491..2373510) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2373504) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2373512..2373519 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2373534..2373553 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2373539 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2373600..2374046 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2373600..2374046 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2374047..2374775 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2374101..2375174) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2374101..2375174) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2374120) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2375196..2375215) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2375200) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2375229..2375236) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2375271..2375274 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2375289..2375308 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2375294 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2375333..2375650 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2375333..2375650 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2375650 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2375703..2377403) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2375703..2377403) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2375722) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2377435..2377453) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2377442) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2377468..2377474) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2377485..2378255) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2377485..2378255) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2378256..2378344) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2378342..2378361) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2378344) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2378377..2378381) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2378401..2379042) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2378401..2379042) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2378411) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2378476) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2379068..2379087) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2379077) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2379079..2379527) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2379103..2379107) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2379186..2379192 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2379207..2379218 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2379214 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2379249..2379527 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2379249..2379527 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2379528..2379698 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2379528..2380142) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2379528..2380142) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2379676 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2380143..2380478) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2380470..2380489) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2380478) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2380504..2380511) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2380505..2382661) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2380505..2382661) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2382202,2382204) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2382687..2383616) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2382687..2383616) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2383665..2384579) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2383665..2384579) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2384342..2384360) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2384350) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2384374..2384380) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2384605..2385156) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2384605..2385156) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2385019..2385038 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2385022 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2385179..2385198) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2385191) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2385214..2385217) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2385239..2385246 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2385257..2385276 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2385260..2385271) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2385264 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2385274) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2385285..2385291) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2385305..2386240 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2385305..2386240 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2386216 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2386274..2387665) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2386274..2387665) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2386286) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2387666..2388106) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2387692..2387697 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2387711..2387730 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2387724 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2387762..2389060 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2387762..2389060 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2388083..2388102) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2388106) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2388117..2388123) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2389047 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2389100..2390257) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2389100..2390257) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2389125) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2389373..2389378 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2389393..2389411 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2389401 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2390254..2390964) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2390254..2390964) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2390978..2390993) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2390995) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2391005..2391014) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2391021..2391022 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2391034..2391139 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2391034 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2391042..2391052 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2391105..2391111 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2391126..2391145 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2391141..2391254 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2391141 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2391255..2391476 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2391255..2391476 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2391459 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2391528 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2391597..2392316) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2391597..2392316) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2391611) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2392382) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2392385..2394019) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2392385..2394019) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2394051..2394070) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2394067) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2394137..2394141 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2394157..2394176 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2394175 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2394221..2395483 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2394221..2395483 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2395484..2395582 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2395556..2395562 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2395578..2395596 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2395584..2395671 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2395584 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2395672..2397210 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2395672..2397210 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2397190 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2397247..2397429) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2397247..2397429) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2397266) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2397444..2397462) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2397464) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2397478..2397483) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2397497..2398165) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2397497..2398165) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2398187..2399473) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2398187..2399473) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2399485..2399988) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2399485..2399988) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2399985..2401106) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2399985..2401106) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2401114..2402079) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2401114..2402079) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2402105) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2402106..2402125) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2402140..2402147) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2402235..2402242 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2402255 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2402258..2402277 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2402295..2404613 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2402295..2404613 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2404603 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2404654..2406150) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2404654..2406150) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2404656) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2406175..2407035) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2406175..2407035) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2407111..2407130) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2407120) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2407146..2407153) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2407242..2408003) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2407242..2408003) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2407271) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2408004..2408079) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2408080..2409267) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2408080..2409267) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2409336..2410343) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2409336..2410343) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2410346..2411041) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2410346..2411041) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2411038..2412207) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2411038..2412207) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2411074..2411081 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2411096..2411115 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2411114 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2412197..2413543) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2412197..2413543) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2412613..2412617 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2412632 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2412633..2412651 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2413533..2414309) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2413533..2414309) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2414310..2414402) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2414388..2414407) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2414402) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2414422..2414429) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2414519..2415418) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2414519..2415418) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2415441..2415459) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2415458) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2415470..2415478) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2415548..2415555 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2415571..2415590 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2415577 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2415636..2416670 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2415636..2416670 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2416619..2416626 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2416641..2416649 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2416658 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2416704..2417984 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2416704..2417984 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2417977..2418888 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2417977..2418888 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2418885..2419715 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2418885..2419715 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2419688..2419692 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2419708..2419727 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2419716 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2419735..2421033 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2419735..2421033 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2421014 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2421055..2421366) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2421055..2421366) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2421066) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2421390..2421409) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2421398) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2421424..2421431) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2421432 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2421483..2423897) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2421483..2423897) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2421487) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2423898..2423993) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2424007..2424221) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2424007..2424221) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2424038) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2424233..2424252) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2424254) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2424258..2424263 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2424267..2424272) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2424279..2424297 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2424292..2424732 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2424292 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2424324..2424659) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2424324..2424659) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2424654..2424918) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2424903..2424922) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2424918) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2424937..2424944) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2424957..2424964 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2424978..2424997 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2424994 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2424996..2425063 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2425064..2425849 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2425064..2425849 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2425850..2425906 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2426086..2427279) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2426086..2427279) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2426106) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2427280..2427378) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2427359..2427378) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2427378) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2427392..2427399) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2427416..2427419 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2427434..2427453 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2427438 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2427468..2428214 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2427468..2428214 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2428109 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2428208 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2428251..2430191) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2428251..2430191) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2428262) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2430181..2430942) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2430181..2430942) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2430966..2430984) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2430985) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2431044..2432048) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2431044..2432048) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2431083) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2432041..2432736) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2432041..2432736) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2432760..2432778) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2432772) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2432794..2432797) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2432833..2434143) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2432833..2434143) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2432855) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2434133..2434828) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2434133..2434828) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2434843..2435820) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2434843..2435820) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2435850..2436836) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2435850..2436836) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2436706..2436715 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2436722 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2436728..2436743 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2436830..2437708) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2436830..2437708) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2437701..2438093) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2437701..2438093) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2438094..2438338) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2438127..2438264) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2438127..2438264) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2438262 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2438333..2438352) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2438338) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2438366..2438373) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2438419..2438691) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2438419..2438691) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2438426) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2438731..2438742) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2438735..2438743 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2438735) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2438746 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2438757..2438763) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2438757..2438775 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2438786..2438791 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2438805..2438824 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2438812 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2438853..2439821 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2438853..2439821 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2439818..2440402 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2439818..2440402 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2440366 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2440392..>2440523) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2440392..>2440523) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2440433) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2440526..2440527 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2440527..2440542) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2440533..2440552) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2440542) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2440544..2440678) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2440564..2440571) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2440653..2440672) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2440678) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2440771..2442162) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2440771..2442162) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2440779) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2442163..2442297) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2442298..2444196) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2442298..2444196) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2443354..2443360 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2443375..2443386 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2443387 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2444197..2444320) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2444346..2445548) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2444346..2445548) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2444365) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2445591..2445602) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2445597) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2445599..2445715) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2445616..2445622) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2445716..2445854) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2445716..2445854) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2445814 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2445863..2445882) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2445878) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2445899..2445903) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2445975..2445982 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2445994 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2445996..2446015 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2446051..2447634 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2446051..2447634 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2447623 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2447673..2447915) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2447673..2447915) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2447687) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2447967..2448740) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2447967..2448740) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2448741..2448831) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2448807..2448816 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2448820..2448839) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2448828 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2448829..2448848 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2448833) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2448854..2448861) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2448891..2449895 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2448891..2449895 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2449908..2450690 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2449908..2450690 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2449912..2451460) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2450665..2451477 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2450665..2451477 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2451462 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2451504..2451980) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2451504..2451980) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2451505) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2452010..2452029) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2452023) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2452025..2452159) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2452159) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2452161..2452172) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2452187..2452193) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2452189..2452593) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2452189..2452593) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2452621..2452640) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2452638) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2452640..2452726) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2452653..2452662) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2452759..2453196) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2452759..2453196) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2452771) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2453213..2453231) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2453231) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2453233..2453458) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2453246..2453252) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2453288..2453307 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2453289..2453465 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2453289..2453465 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2453290 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2453459..2453896) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2453459..2453896) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2453485 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2453915..2453934) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2453936) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2453945..2453953) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2454016..2454489) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2454016..2454489) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2454025) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2454112) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2454490..2454841) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2454561..2454568 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2454581..2454600 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2454586 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2454618..2454845 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2454618..2454845 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2454842..2455405) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2454842..2455405) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2455430..2455449) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2455445) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2455499..2455747) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2455499..2455747) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2455520) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2455775..2455794) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2455808..2455815) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2455812) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2455874..2455880 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2455894..2455905 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2455906 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2455952..2457283 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2455952..2457283 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2457327..2458367 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2457327..2458367 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2458361..2458367 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2458382..2458393 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2458392 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2458421..2458579 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2458421..2458579 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2458568 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2458598..2459485) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2458598..2459485) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2458621) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2459475..2460782) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2459475..2460782) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2460788..2461540) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2460788..2461540) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2461559..2462479) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2461559..2462479) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2462515..2462526) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2462516) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2462518..2462609) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2462540..2462546) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2462594 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2462595..2462614) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2462597..2462609 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2462609) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2462611..2462692) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2462629..2462636) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2462692) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2462701..2462720) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2462734..2462741) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2462759..2463874) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2462759..2463874) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2462802) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2463871..2465331) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2463871..2465331) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2464774..2464792) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2464778) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2464807..2464813) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2465420) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2465422..2466237) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2465422..2466237) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2466272..2467096) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2466272..2467096) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2466354..2466373) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2466354) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2466389..2466392) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2466520) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2466530..2466541) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2466556..2466562) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2467084..2468826) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2467084..2468826) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2468823..2470238) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2468823..2470238) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2470239..2470351) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2470331..2470350) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2470351) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2470353..2470503) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2470366..2470369) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2470464..2470470 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2470484..2470503) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2470484..2470495 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2470492 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2470503) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2470517..2470526) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2470528..2471247 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2470528..2471247 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2470598..2471255) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2471236 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2471256..2472074) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2471256..2472074) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2472095..2472114) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2472109) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2472129..2472137) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2472175..2472183 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2472196..2472215 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2472197 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2472246..2473532 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2472246..2473532 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2473529..2474479 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2473529..2474479 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2474482..2475705 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2474482..2475705 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2475629) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2475706..2476273 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2475779..2476210) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2475779..2476210) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2475805) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2476212..2477267) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2476212..2477267) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2477282..2478415) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2477282..2478415) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2478448..2478467) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2478467) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2478480..2478489) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2478553..2478562 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2478576..2478595 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2478578 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2478605..2479678 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2478605..2479678 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2478902..2478908 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2478919 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2478922..2478933 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2479667 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2479705..2479711 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2479726 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2479727..2479745 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2479758..2480225 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2479758..2480225 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2480197 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2480256..2482652) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2480256..2482652) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2480271) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2482639..2484093) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2482639..2484093) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2484090..2485121) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2484090..2485121) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2485145..2486287) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2485145..2486287) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2486284..2488167) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2486284..2488167) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2486993..2488412 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2488199..2488214) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2488212) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2488229..2488234) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2488279) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2488400..2488471) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2488400..2488471) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2488497..2488587) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2488497..2488587) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2488591..2488665) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2488591..2488665) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2488676..2488752) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2488676..2488752) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2488768..2488841) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2488768..2488841) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2488852..2488927) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2488852..2488927) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2488945..2489020) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2488945..2489020) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2489033..2489109) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2489033..2489109) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2489121..2489197) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2489121..2489197) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2489215..2489307) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2489215..2489307) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2489314..2489390) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2489314..2489390) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2489393..2489469) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2489393..2489469) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2489489..2489561) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2489489..2489561) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2489567..2489643) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2489567..2489643) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2489659..2489735) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2489659..2489735) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2489745..2489830) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2489745..2489830) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2489845..2489919) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2489845..2489919) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2489925..2490011) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2489925..2490011) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2490022..2490097) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2490022..2490097) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2490135..2490210) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2490135..2490210) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2490243..2490318) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2490243..2490318) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2490339..2490456) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2490339..2490456) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2490512..2493439) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2490512..2493439) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2493607..2495161) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2493607..2495161) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2494963,2494965) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2495162..2495453) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2495289..2495297 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2495295 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2495405 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2495426..2495445) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2495453) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2495455..2496421) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2495459..2495466) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2495578..2495581 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2495593 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2495596..2495615 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2495626..2495727 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2495626..2495727 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2495726 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2495827..2496405 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2495827..2496405 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2496395 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2496447..2496968) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2496447..2496968) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2496465) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2496537) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2496986..2498515) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2496986..2498515) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2498536..2499060) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2498536..2499060) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2499104..2499119) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2499110) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2499112..2499199) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2499131..2499140) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2499184..2499202) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2499194 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2499198..2499217 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2499199) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2499217..2499222) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2499228..2499716 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2499228..2499716 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2499693 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2499722..2500300) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2499722..2500300) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2499738..2500129 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2499749) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2500334..2500353) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2500343) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2500367..2500374) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2500388..2501596) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2500388..2501596) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2500409) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2501365..2501384) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2501377) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2501399..2501406) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2501613..2503085) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2501613..2503085) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2503136..2503155) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2503137) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2503170..2503177) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2503197..2503203 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2503217..2503236 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2503232 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2503284..2503826 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2503284..2503826 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2503809 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2503903..2503910 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2503923..2504023 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2503923 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2503925..2503944 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2504024..2504569 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2504024..2504569 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2504556 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2504661..2504668 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2504682..2504701 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2504689 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2504694..2504862 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2504694..2504862 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2504843 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2504935..2505603 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2504935..2505603 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2505610..2506947 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2505610..2506947 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2506933 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2506983..2507246) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2506983..2507246) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2507001) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2507286..2507305) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2507288) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2507318..2507325) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2507355..2508203) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2507355..2508203) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2508248..2508267) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2508258) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2508282..2508289) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2508364..2509899) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2508364..2509899) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2508373) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2509557..2509657 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2509617 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2509683 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2509900..2510067) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2510056..2510075) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2510067) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2510069..2510946) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2510090..2510097) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2510309..2510318 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2510332..2510351 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2510332 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2510384..2510869 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2510384..2510869 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2510870..2511156 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2510976..2511048) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2510976..2511048) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2510991) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2511035) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2511059..2511078) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2511079) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2511093..2511096) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2511113 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2511156..2511986) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2511156..2511986) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2511167) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2511987..2512078) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2512079..2513245) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2512079..2513245) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2513241..2513245 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2513253..2513267 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2513269..2513288) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2513269 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2513288) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2513302..2513309) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2513367..2513374 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2513380 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2513385..2513404 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2513427..2514440 /gene="iolU" /locus_tag="PG10_BSU_31170_3'_ext" /old_locus_tag="BSU_31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /modified_by="User" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQANSCQSA FSH*" /label="PG10_BSU_31170_3'_ext" gene 2513427..2514440 /gene="iolU" /locus_tag="PG10_BSU_31170_3'_ext" /old_locus_tag="BSU_31170" /modified_by="User" /label="PG10_BSU_31170_3'_ext" downshifts 2514384 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR join(2514409,2514416) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_029" N_region 2514410..2514415 /note="EcoRI site (GAATTC)" /created_by="User" /label="IIG_Bs27_029" CDS complement(2514437..2515789) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2514437..2515789) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2514448) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2514604..2514622) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2514621) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2514638..2514643) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2515762) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2515765..2515776) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2515821..2515840) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2515827) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2515829..2515900) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2515855..2515858) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2515901..2517073) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2515901..2517073) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2516236..2517157 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2517106..2517125) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2517119) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2517142..2517145) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2517177..2518340) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2517177..2518340) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2517192) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2518355..2518374) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2518373) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2518375..2518530) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2518389..2518396) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2518426..2518432 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2518447..2518465 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2518457 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2518458..2518516 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2518503..2518509 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2518505..2518516) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2518518 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2518523..2518534 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2518530..2518536) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2518530) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2518532..2518843) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2518570..2518806 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2518570..2518806 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2518766 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2518832 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2518884..2519276) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2518884..2519276) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2518888) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2519318..2519337) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2519325) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2519327..2519477) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2519353..2519357) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2519380..2519386 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2519393..2520377 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2519393 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2519401..2519419 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2519478..2520638) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2519478..2520638) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2520530..2520536 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2520548 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2520550..2520554 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2520639..2521139) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2520639..2521139) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2521169..2521188) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2521175..2521181 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2521190) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2521196..2521207 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2521196 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2521199..2521206) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2521208..2521286 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2521287..2522108 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2521287..2522108 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2522088 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2522135) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2522137..2522397) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2522137..2522397) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2522387..2522390 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2522405..2522424 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2522417 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2522418..2522483 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2522423..2522442) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2522428) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2522454..2522460) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2522484..2523647 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2522484..2523647 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2523710..2523716 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2523728..2523747 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2523738 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2523773..2525059 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2523773..2525059 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2524775..2525517) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2525054..2525061 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2525075..2525094 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2525076 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2525105..2525491 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2525105..2525491 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2525473 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2525518..2526135) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2525518..2526135) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2526170..2526188) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2526187) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2526189..2528277) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2526203..2526208) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2526251..2526254 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2526269..2526288 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2526280 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2526346..2527524 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2526346..2527524 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2527562..2527568 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2527580..2527599 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2527585 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2527617..2529491 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2527617..2529491 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2528257..2528276) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2528277) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2528290..2528299) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2529512..2529925 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2529512..2529925 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2529917 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2530128..2530685) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2530128..2530685) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2530149..2530168 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2530159 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2530169) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2530181..2530862 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2530711..2530730) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2530719) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2530746..2530750) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2530863..2532464 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2530863..2532464 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2532457..2533164 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2532457..2533164 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2533149 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2533328..2533335 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2533346..2533635 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2533346 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2533350..2533369 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2533636..2534715 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2533636..2534715 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2534791..2536323 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2534791..2536323 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2536316..2537362 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2536316..2537362 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2537363..2538322 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2537363..2538322 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2538323..2538444 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2538417..2538420 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2538435..2538454 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2538446 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2538476..2539822 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2538476..2539822 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2539805 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2539858..2540073) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2539858..2540073) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2540013..2540019 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2540033..2540044 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2540037 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2540084..2540102) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2540091) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2540116..2540123 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2540118..2540123) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2540138..2540233 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2540138..2540157 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2540138 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2540196..2540200 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2540216..2540235 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2540235..2540384 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2540235 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2540304..2542709 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2540304..2542709 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2542702..2543133 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2542702..2543133 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2543133..2543474 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2543133..2543474 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2543365..2543465 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2543425 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2543467..2544948 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2543467..2544948 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2544200..2546068) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2544954..2545430 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2544954..2545430 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2545430..2545714 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2545430..2545714 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2545698..2546072 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2545698..2546072 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2546043 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2546111..2546491) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2546111..2546491) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2546113) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" SCAR join(2546509,2546516) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_035" N_region 2546510..2546515 /note="EcoRI site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs27_035" S_feature complement(2546516..2546629) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S1215" promotor_-10 complement(2546623..2546642) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2546629) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2546656..2546662) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2546700..2546840) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2546700..2546840) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2546729) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2546841..2546927) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2546911..2546930) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2546927) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2546944..2546950) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2547027..2547045) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2547037) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2547060..2547066) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2547062..2547187 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2547062..2547187 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2547215..2547644) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2547240..2547245 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2547257) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2547260..2547278 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2547262 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2547301..2547669 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2547301..2547669 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2547645..2548874) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2547645..2548874) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2547670..2548983 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2548909..2548928) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2548928) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2548941 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2548943..2548950) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2549011..2550483) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2549011..2550483) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2549021) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2550364..2550368 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2550371 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2550481 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2550499..2551050) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2550499..2551050) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2551072..2551091) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2551085) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2551104..2551111) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2551147..2551545) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2551147..2551545) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2551546..2551616) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2551617..2551865) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2551617..2551865) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2551888..2551907) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2551899) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2551923..2551926) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2551938..2552159) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2551938..2552159) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2551965) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2552153 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2552177..2552196) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2552183) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2552209..2552218) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2552219..2553328) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2552219..2553328) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2552980..2552987 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2553002..2553021 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2553011..2553405 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2553011 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2553376..2553395) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2553392) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2553394..2553834) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2553397..2553399 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2553407 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2553409..2553414) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2553415..2553434 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2553443..2553832 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2553443..2553832 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2553873..2554109) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2553873..2554109) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2553879) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2554129..2554148) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2554143) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2554145..2554285) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2554162..2554171) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2554286..2554816) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2554286..2554816) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2554836..2554855) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2554847) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2554849..2554935) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2554867..2554875) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2554930..2554949) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2554937) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2554963..2554972) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2555014..2555745) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2555014..2555745) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2555044) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2555760..2555779) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2555771) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2555794..2555801) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2555808..2556263) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2555808..2556263) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2556216..2556222 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2556237..2556255 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2556245..2558612 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2556245 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2556295..2559525) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2556295..2559525) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2559522..2564009) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2559522..2564009) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2563284..2563290 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2563305..2563323 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2563311..2564273 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2563311 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2564070..2565425) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2564070..2565425) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2564091) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2565440..2565679) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2565440..2565679) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2565749..2566042) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2565749..2566042) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2565759) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2566036 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2566043..2566121) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2566084..2566091 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2566101..2566120) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2566102 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2566106..2566123 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2566121) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2566135..2566142) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2566180..2566185 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2566200..2566219 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2566212..2566318 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2566212 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2566387..2566393 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2566407..2566426 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2566410 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2566515..2566518 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2566527 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2566530..2566549) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2566534..2566553 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2566552) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2566563..2567831 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2566563..2567831 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2566564..2566571) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2567891..2567910 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2567896 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2567933..2569069 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2567933..2569069 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2569069 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2569118..2569126 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2569136 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2569138..2569156 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2569181..2569858 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2569181..2569858 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2569842 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2569902..2570111) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2569902..2570111) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2569914) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2570127..2577263) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2570127..2577263) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2577283..2578221) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2577283..2578221) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2578249..2579868) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2578249..2579868) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2579897..2581093) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2579897..2581093) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2580941..2580948 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2580963..2580982 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2580970 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2581119..2581904) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2581119..2581904) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2581905..2582014) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2582009..2582028) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2582014) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2582016..2582097) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2582042..2582049) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2582098..2582967) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2582098..2582967) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2582968..2583048) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2583032..2583051) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2583048) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2583065..2583072) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2583181..2583777) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2583181..2583777) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2583778..2583862) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2583813..2583820 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2583830 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2583835..2583854 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2583856..2583870) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2583862) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2583878..2583882) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2583878..2584480 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2583878..2584480 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2584466 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2584550..2585878) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2584550..2585878) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2584566) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2585932..2585951) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2585935) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2585966..2585973) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2586025..2587527) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2586025..2587527) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2586040) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2587092..2587106 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2587108 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2587528..2587602) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2587550..2587557 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2587568..2587587 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2587570..2587684 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2587570 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2587597..2587616) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2587607) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2587685..2588161 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2587685..2588161 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2588110 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2588192..2588848) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2588192..2588848) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2588220) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2588496..2588505 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2588519..2588538 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2588536 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2588538..2588984 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2588862) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2588864..2588875) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2588890..2588896) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2588941 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2588952..2589272) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2588952..2589272) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2588966) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2588986..2589196 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2589138..2589238 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2589198..2589307 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2589198 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2589264 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2589291..2589310) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2589296) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2589309..2589860 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2589325..2589332) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2589326..2589469) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2589326..2589469) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2589493..2589512) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2589514) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2589528..2589531) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2589642..2590862) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2589642..2590862) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2589670) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2590863..2590990) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2590990) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2590992..2591056) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2590992..2591010) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2591026..2591031) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2591047..2591066) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2591055) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2591081..2591088) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2591130..2591137 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2591149..2591168 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2591149 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2591194..2592192 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2591194..2592192 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2591217..2591235) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2591232) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2591252..2591257) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2592168 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2592231..2592371) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2592231..2592371) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2592243) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2592372..2592501) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2592482..2592501) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2592501) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2592503..2592750) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2592515..2592521) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2592558..2592565 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2592579..2592598 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2592587 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2592650..2593630 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2592650..2593630 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2592751) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2592755..2592766) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2592780..2592786) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2593598 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2593703) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2593704..2594327) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2593704..2594327) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2594351..2594869) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2594351..2594869) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2594916..2594935) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2594928) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2594930..2595038) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2595025..2595042) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2595036) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2595057..2595064) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2595192) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2595207..2595569) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2595207..2595569) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2595600..2595619) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2595610) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2595633..2595640) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2595648..2596502) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2595648..2596502) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2596218..2596237) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2596226) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2596250..2596259) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2596524..2596543) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2596538) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2596558..2596561) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2596625..2597839) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2596625..2597839) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2597174..2597180 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2597195..2597213 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2597202 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2597206..2597975 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2597876..2597895) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2597881) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2597910..2597917) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2597932 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2597976..2598212) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2597976..2598212) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2597977..2598393 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2597994) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2598177..2598178) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2598182..2598186) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2598184) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2598227..2598246) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2598228) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2598260..2598267) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2598370..2598375 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2598389..2598408 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2598395 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2598475..2599542 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2598475..2599542 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2599526 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2599568..2599894) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2599568..2599894) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2599591) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2599926..2599945) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2599943) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2599958..2599965) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2599978..2599982 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2599994..2600329 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2599994..2600329 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2599995..2600014 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2600000 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2600119) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2600307 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2600371..2602344) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2600371..2602344) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2600383) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2602359..2602377) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2602382) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2602389..2602397) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2602452..2603381) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2602452..2603381) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2602465) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2603378..2604436) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2603378..2604436) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2604436..2605737) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2604436..2605737) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2605622..2605631 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2605646..2605665 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2605653 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2605738..2605819) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2605804..2605823) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2605819) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2605821..2605937) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2605838..2605845) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2605938..2606957) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2605938..2606957) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2606765..2606770 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2606786..2606804 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2606790 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2606980..2606998) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2606987) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2606996..2607001 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2607014..2607019) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2607017..2607081 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2607017..2607035 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2607017 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2607054..2607063 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2607076..2607095 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2607083 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2607110..2607610 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2607110..2607610 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2607637..2608407) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2607637..2608407) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2607665) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2608436..2608870) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2608436..2608870) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2608894..2609169) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2608894..2609169) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2609189..2609208) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2609214) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2609216..2609908) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2609222..2609229) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2609232..2609238 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2609253..2609264 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2609261 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2609284..2609916 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2609284..2609916 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2609877 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2609932..2610828) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2609932..2610828) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2609953) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2610829..2610963) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2610950..2610969) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2610963) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2610985..2610989) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2611003..2611009 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2611023..2611034 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2611035 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2611063..2612043 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2611063..2612043 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2611141) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2611155..2611174) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2611191..2611194) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2612035 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2612071..2612835) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2612071..2612835) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2612087) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2612849..2612867) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2612857) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2612883..2612888) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2612908..2613213) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2612908..2613213) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2612916) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2613227..2613246) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2613250) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2613260..2613268) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2613278..2614666) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2613278..2614666) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2614686..2615507) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2614686..2615507) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2615525..2616373) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2615525..2616373) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2615892..2615897 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2615913..2615931 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2615927 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2616384..2616403) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2616399) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2616411..2616758) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2616411..2616758) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2616771..2616790) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2616790) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2616804..2616810) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2616855..2618195) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2616855..2618195) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2616883) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2617939) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2618252..2618258 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2618272..2618291 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2618274..2618292) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2618280 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2618281..2618369 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2618291) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2618308..2618313) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2618370..2619965 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2618370..2619965 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2620110..2621459 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2620110..2621459 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2621465..2622757 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2621465..2622757 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2622770..2624254 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2622770..2624254 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2624254..2624598 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2624254..2624598 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2624320..2624323 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2624341..2624360 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2624353 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2624573 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2624614..2625001) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2624961..2624970 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2624983..2625002 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2624986 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2625022..2625153) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2625022..2625153 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2625022..2625153 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2625022..2625153) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2625154..2625222 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2625189 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2625359..2625880) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2625359..2625880) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2625871..2628108) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2625871..2628108) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2628109..2628942) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2628109..2628942) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2628939..2629556) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2628939..2629556) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2629048) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2629553..2630545) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2629553..2630545) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2630546..2630632) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2630610..2630629) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2630632) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2630643..2630648) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2630774..2632024) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2630774..2632024) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2632041..2633279) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2632041..2633279) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2633502..2633639 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2633502..2633639 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2633661..2633664 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2633679..2633698 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2633680 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2633721..2634587 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2633721..2634587 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2634590 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2634621..2635724) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2634621..2635724) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2634636) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2635725..2636658) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2635762..2635769 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2635783..2635802 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2635793 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2635844..2635850 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2635861 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2635865..2635884 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2635906..2636634 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2635906..2636634 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2636659..2637513) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2636659..2637513) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2636846..2636865) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2636858) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2637016..2637116) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2637056) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2637527..2638429) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2637527..2638429) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2638433..2639311) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2638433..2639311) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2639369..2640637) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2639369..2640637) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2640528..2640628 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2640588 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2640708) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2640718..2641704) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2640718..2641704) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2641651 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2641654..2641658 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2641747..2641766) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2641760) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2641781..2641788) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2641918) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2641920..2642294) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2641920..2642294) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2642358) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2642365..2642376) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2642390..2642396) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2642397..2643515) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2642397..2643515) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2643540..2643559) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2643546) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2643548..2644158) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2643573..2643579) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2643612..2643621 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2643635..2643654 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2643639 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2643652..2643667) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2643656) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2643674..2643678) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2643674..2643820 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2643674..2643820 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2643820..2644095 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2643820..2644095 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2643964) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2643980..2643994) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2644003..2644007) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2644075 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2644159..2644542) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2644159..2644542) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2644543..2644652) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2644653..2644931) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2644653..2644931) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2644929..2644948) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2644953) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2644963..2644970) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2645094..2645200) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2645137) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2645201..2646598) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2645201..2646598) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2646396 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2646619..2647062) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2646619..2647062) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2647052..2648272) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2647052..2648272) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2648272..2649585) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2648272..2649585) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2649603..2650388) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2649603..2650388) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2650432..2650451) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2650433) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2650465..2650472) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2650489..2650508) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2650498) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2650500..2650581) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2650524..2650528) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2650545..2650792) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2650545..2650792) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2650582..2650719) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2650582..2650719) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2650720..2650804) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2650788..2650807) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650804) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2650806..2650912) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2650823..2650826) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2650913..2651290) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2650913..2651290) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2651307..2651318) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2651313) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2651332..2651338) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2651375..2652199) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2651375..2652199) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2651383) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2651532) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2651559..2651564 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2651580..2651598 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2651582 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2652213..2652881) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2652213..2652881) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2652874..2653899) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2652874..2653899) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2653900..2654004) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2654005..2654111) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2654005..2654111) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2654074 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2654138..2654157) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2654150) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2654152..2654225) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2654173..2654180) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2654226..2654570) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2654226..2654570) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2654571..2654676) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2654677..2654997) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2654677..2654997) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2654999..2655439) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2654999..2655439) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2655439..2655675) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2655439..2655675) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2655451) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2655690) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2655695..2655706) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2655721..2655727) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2655731..2656114) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2655731..2656114) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2656141..2656160) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2656152) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2656173..2656180) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2656181..2656537) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2656181..2656537) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2656560..2656579) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2656570) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2656593..2656598) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2656648..2658432) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2656648..2658432) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2656658) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2658447..2659622) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2658447..2659622) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2659633..2662002) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2659633..2662002) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2661421..2661426 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2661441..2661459 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2661444 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2662070..2662089) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2662073) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2662081..2662347) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2662103..2662110) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2662128..2662134 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2662149..2662160 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2662171 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2662177..2662323 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2662177..2662323 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2662324..2663350 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2662348..2663256) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2662348..2663256) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2663257..2663779) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2663351..2663596 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2663351..2663596 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2663609..2663941 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2663609..2663941 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2663762..2663781) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2663779) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2663795..2663804) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2663930 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2664002..2664009 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2664023..2664042 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2664034 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2664100..2664567 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2664100..2664567 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2664564..2666189 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2664564..2666189 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2666174 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2666225..2666608) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2666225..2666608) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2666627..2667016) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2666627..2667016) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2667038..2667367) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2667038..2667367) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2667402..2667421) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2667409..2667416 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2667416) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2667431..2667450 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2667435..2667442) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2667441 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2667501..2668388 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2667501..2668388 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2668408..2668695) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2668408..2668695) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2668420) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2668720..2669547) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2668720..2669547) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2668736) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2669548..2669685) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2669670..2669689) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2669685) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2669705..2669708) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2669765..2670202) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2669765..2670202) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2670226..2670244) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2670232) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2670260..2670265) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2670312..2671820) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2670312..2671820) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2670333) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2671811..2672107) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2671811..2672107) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2672130..2672149) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2672146) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2672164..2672167) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2672184..2672189 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2672201..2672220 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2672201 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2672241..2673083 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2672241..2673083 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2672613..2672619 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2672634..2672645 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2672642 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2673110..2673117 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2673126 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2673129..2673148 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2673173..2673634 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2673173..2673634 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2673610 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2673678..2675054) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2673678..2675054) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2673686) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2675055..2675226) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2675207..2675226) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2675226) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2675237..2675244) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2675287..2675306) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2675297..2675316 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2675299 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2675305) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2675307..2676370) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2675321..2675328) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2675332..2676009 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2675332..2676009 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2676006..2677361 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2676006..2677361 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2676460..2677388) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2677329 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2677389..2677553) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2677389..2677553) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2677577..2677584 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2677598..2677617 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2677602..2677621) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2677608..2677720 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2677608 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2677615) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2677617..2677895) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2677635..2677642) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2677721..2678596 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2677721..2678596 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2677885..2677904) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2677895) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2677897..2678438) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2677918..2677925) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2678430..2678448) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2678438) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2678440..2678569) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2678461..2678468) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2678571 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2678614) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2678632..2680020) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2678632..2680020) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2680044) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2680049..2680067) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2680078..2680086) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2680087..2680272) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2680087..2680272) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2680276 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2680316..2680335) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2680325..2680331 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2680330) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2680345..2680356 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2680348 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2680351..2680354) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2680390..2681838 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2680390..2681838 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2681386..2684029) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2681807..2682904 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2681807..2682904 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2682901..2684022 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2682901..2684022 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2684030..2684665) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2684030..2684665) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2684643..2685725) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2684643..2685725) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2685722..2686447) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2685722..2686447) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2686481..2687353) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2686481..2687353) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2687372..2687391) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2687392) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2687406..2687409) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2687454..2688131) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2687454..2688131) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2687470) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2688158..2688538) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2688158..2688538) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2688561..2688580) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2688581) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2688595..2688598) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2688700..2689968) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2688700..2689968) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2688713) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2690002..2690021) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2690013) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2690036..2690043) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2690139) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2690145..2690726) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2690145..2690726) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2690749..2692077) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2690749..2692077) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2692077..2693138) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2692077..2693138) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2693101..2694045) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2693101..2694045) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2694046..2694315) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2694154..2694284) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2694154..2694284) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2694292..2694311) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2694315) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2694317..2695244) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2694327..2694334) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2694377..2694384 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2694399..2694418 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2694403 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2694443..2695234 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2694443..2695234 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2695105 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2695215 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2695272..2696150) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2695272..2696150) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2695289) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2696174..2696192) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2696193) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2696206..2696212) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2696222..2697964) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2696222..2697964) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2697961..2698674) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2697961..2698674) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2698705..2698724) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2698723) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2698827..2699066) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2698827..2699066) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2698834) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2699062..2699080) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2699070..2699600) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2699070..2699600) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2699071) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2699095..2699101) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2699603..2699622) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2699610) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2699615..2699953 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2699615..2699953 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2699637..2699644) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2699653..2699672) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2699665) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2699687..2699693) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2699699..2699799 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2699759 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2699927..2700027 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2699987..2700073 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2699987 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2700074..2701231 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2700074..2701231 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2701217 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2701292..2701702 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2701292..2701702 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2701701 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2701736..2702965) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2701736..2702965) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2701753) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2702958..2703647) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2702958..2703647) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2703631..2704824) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2703631..2704824) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2704868..2704887) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2704881) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2704902..2704909) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2704995..2705804) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2704995..2705804) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2705012) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2705151..2705160 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2705173..2705192 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2705177 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2705820..2706830) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2705820..2706830) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2706830..2707984) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2706830..2707984) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2707917..2707936) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2707934) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2707948..2707955) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2707996..2708003 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2708018..2708037 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2708027 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2708082..2709029 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2708082..2709029 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2709005 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2709049 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2709203 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2709264..2710673) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2709264..2710673) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2709279) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2710091..2710095 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2710113..2710129 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2710120 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2710127..2711094 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2710775) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2710777..2710956) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2710777..2710956) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2710986..2711003) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2710997) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2711018..2711025) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2711051 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2711073..2711213) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2711073..2711213) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2711083) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2711241) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2711243..2711831) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2711246..2711257) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2711271..2711277) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2711303..2711310 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2711324 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2711326..2711345 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2711380..2711862 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2711380..2711862 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2711876..2711883 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2711897..2711916 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2711909 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2711962..2713815 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2711962..2713815 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2713801 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2713843..2714769) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2713843..2714769) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2713855) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2714781..2714800) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2714802) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2714816..2714819) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2714838..2714857 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2714847 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2714880..2715662 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2714880..2715662 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2715634..2716326 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2715634..2716326 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2716318 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2716357..2717187) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2716357..2717187) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2716363) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2717050..2717054 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2717070..2717074 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2717079 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2717189 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2717217..2717236) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2717235) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2717251..2717258) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2717343..2717349 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2717363 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2717364..2717382 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2717410..2717895 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2717410..2717895 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2717894 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2717939..2719951) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2717939..2719951) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2717947) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2719617..2719621) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2719619) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2719952..2720103) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2720080..2720098) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2720103) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2720206..2721921) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2720206..2721921) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2720213) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2721947..2723764) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2721947..2723764) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2723806..2723825) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2723815..2723822 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2723825) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2723828 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2723835..2723854 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2723838..2723845) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2723935..2726259) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2723935..2726259) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2723953) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2726279..2726286 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2726301..2726320 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2726302..2726317) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2726305 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2726307) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2726352..2726371) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2726361) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2726387..2726393) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2726397..2726416) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2726417) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2726430..2726438) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2726444) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2726457..2727065) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2726457..2727065) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2727104..2727123) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2727121) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2727139..2727143) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2727252..2727668) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2727252..2727668) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2727262) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2727673..2728341) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2727673..2728341) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2728393..2728412) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2728408) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2728419) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2728426..2728431) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2728461..2730569) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2728461..2730569) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2730561..2730662) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2730656..2730675) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2730662) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2730691..2730698) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2730729..2733137) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2730729..2733137) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2730751) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2730817) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2733138..2733220) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2733221..2733430) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2733221..2733430) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2733454..2733473) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2733475) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2733486..2733492) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2733504..2733809) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2733504..2733809) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2733773..2733792 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2733784 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2733823..2733842) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2733849) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2733856..2733862) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2733901..2733907 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2733922..2733940 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2733930 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2733937..2735013 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2733937..2735013 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2735000 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2735050..2735685) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2735050..2735685) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2735063) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2735686..2735783) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2735763..2735782) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2735783) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2735796..2735802) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2735845..2737740) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2735845..2737740) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2737791..2737802) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2737791) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2737817..2737823) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2737890) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2737903..2738304) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2737903..2738304) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2738301..2738660) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2738301..2738660) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2738657..2739229) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2738657..2739229) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2739267..2739286) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739272) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2739300..2739307) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2739340..2740134) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2739340..2740134) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2740155..2740173) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740167) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2740188..2740194) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2740200..2740219) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740211) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2740213..2740278) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2740233..2740240) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2740320..2740679) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2740320..2740679) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2740323) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2740663..2740671) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740673) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2740686..2740691) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2740731..2740750) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740739) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2740741..2740805) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2740763..2740767) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2740805) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2740806..2740825) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2740840..2740847) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2740856..2741326) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2740856..2741326) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2741153..2741253 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2741213 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2741323 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2741371..2741390) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2741377) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2741379..2741470) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2741406..2741409) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2741471..2743810) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2741471..2743810) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2742571..2742574 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2742590..2742593 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2742599 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2743829..2744569) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2743829..2744569) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2744225..2744243) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2744237) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2744258..2744264) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2744597..2744615) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2744611) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2744699) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2744701..2744931) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2744701..2744931) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2744961..2744980) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2744982) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2744995..2744998) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2745020..2745026 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2745040..2745051 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2745041 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2745080..2745850 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2745080..2745850 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2745102..2745110 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2745121..2745139 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2745151 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2745890..2746123) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2745890..2746123) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2746214..2746221 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2746229 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2746233..2746252 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2746275..2746682 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2746275..2746682 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2746712..2747131 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2746712..2747131 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2747169..2747176 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2747190..2747209 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2747197 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2747223..2747549 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2747223..2747549 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2747550..2747634 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2747605..2747612 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2747625..2747643 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2747636 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2747674..2749374 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2747674..2749374 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2748390..2749383) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2749352 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2749414..2750094) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2749414..2750094) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2749428) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2749788..2749794 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2749809..2749827 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2749814..2752565 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2749814 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2750111..2751031) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2750111..2751031) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2751043..2751696) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2751043..2751696) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2751713..2752858) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2751713..2752858) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2752859..2752926) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2752926) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2752927..2752946) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2752957..2752961 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2752961..2752964) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752977..2752995 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2752982 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2753077..2753081 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2753097..2753116 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2753100 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2753142..2753675 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2753142..2753675 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2753342..>2753741) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2753664 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2753741,2753748) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2753742..2753747 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2753748..2753823 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2753748..2753814) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2753819..2754508) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2753819..2754508) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2753859) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2754451..2754459 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2754473..2754492 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2754487 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2754526..2755437) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2754526..2755437) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2755457..2756110) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2755457..2756110) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2756133..2757275) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2756133..2757275) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2757319..2757338) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2757334) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2757353..2757356) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2757472..2757479 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2757492..2757511 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2757503 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2757539..2758096 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2757539..2758096 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2758097..2758861 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2758114..2758749) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2758114..2758749) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2758127) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2758790..2758808) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2758796) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2758824..2758830) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2758835..2758842 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2758854..2758873 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2758863 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2758899..2759513 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2758899..2759513 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2759499 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2759567..2759570 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2759585..2759604 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2759593 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2759645..2760343 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2759645..2760343 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2760316 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2760379..2762196) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2760379..2762196) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2760398) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2760569) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2762238..2762257) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2762242..2762261 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2762247 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2762251) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2762316..2762783 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2762316..2762783 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2762780 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2762828..2764120) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2762828..2764120) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2762838) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2764150..2765685) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2764150..2765685) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2765678..2766439) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2765678..2766439) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2766470..2767654) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2766470..2767654) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2767655..2767895) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2767895) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2767897..2767970) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2767909..2767928) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2767944..2767948) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2767971..2768978) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2767971..2768978) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2768897..2768900 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2768917..2768919 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2768919 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2769025..2770047) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2769025..2770047) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2769041) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2769069..2769070) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2770048..2770159) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2770085 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2770140..2770159) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2770159) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2770161..2770271) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2770173..2770180) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2770254..2770273) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2770269) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2770286..2770295) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2770345..2771739) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2770345..2771739) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2770359) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2771838..2771857) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2771852) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2771872..2771879) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2771879..2771886 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2771900..2771919 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2771906 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 2771943..2773031 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 2771943..2773031 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 2773011 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2773080..2774090) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(2773080..2774090) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(2773087) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2774091..2774168) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(2774158..2774177) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2774168) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2774191..2774198) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2774247..2775125) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(2774247..2775125) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 2774783..2774789 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2774804..2774815 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2774815 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2775159..2775166 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2775172..2775191) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(2775177) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 2775180..2775199 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2775182 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2775205..2775209) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 2775225..2776142 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 2775225..2776142 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 2776131 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2776183..2777526) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(2776183..2777526) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(2777595..2777830) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(2777595..2777830) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(2777729) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2777831..2777927) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(2777928..2778962) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(2777928..2778962) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(2778984..2779002) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2778990) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2779015..2779022) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2779070..2779792) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(2779070..2779792) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(2779086) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(2779792..2781231) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(2779792..2781231) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 2780779..2780782 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2780799 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2780800..2780804 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2780953 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 2781107 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2781108..2781109 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2781258..2781974) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(2781258..2781974) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 2781878..2781885 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2781899..2781901 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2781899 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2781972 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(2781975..2782041) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(2782038..2782057) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(2782041) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(2782072..2782079) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(2782149..2782751) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(2782149..2782751) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(2782768..2783883) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(2782768..2783883) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(2783887..2784624) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(2783887..2784624) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(2783913..2783932) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(2783927) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(2783944..2783951) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(2784625..2785530) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(2784625..2785530) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(2785550..2785568) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2785561) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2785584..2785587) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2785739..2785746 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2785757..2785776 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2785764 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 2785814..2786623 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 2785814..2786623 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 2786659..2787870 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 2786659..2787870 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 2787857 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2787924..2789213) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(2787924..2789213) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(2789293..2791356) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(2789293..2791356) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(2791375..2792226) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(2791375..2792226) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(2792230..2793486) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(2792230..2793486) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(2793526..2794791) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(2793526..2794791) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(2794823..2794842) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2794845) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2794857..2794864) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2794932..2795924) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(2794932..2795924) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(2794966) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(2796054..2796103) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(2796077) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2796104..2796763) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(2796104..2796763) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(2796764..2796869) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(2796861..2796880) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2796870) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2796895..2796898) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2796922..2796929 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2796944..2796963 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2796944 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 2796947..2797052 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(2796953..2796970) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2796957) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2796978..2796984) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2797053..2798744 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 2797053..2798744 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 2798729 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2798771..2800081) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(2798771..2800081) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 2798774..2799844 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(2798783) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2799901..2799920 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2799901..2800159 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 2799901 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2800095..2800114) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2800110) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2800129..2800132) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2800160..2800378 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 2800160..2800378 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 2800357 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" SCAR join(2800385,2800392) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs26" N_region 2800386..2800391 /note="EcoR site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs26" promotor_-35 2800423..2800426 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2800432 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2800443..2800461 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2800477..2801946 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 2800477..2801946 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 2801923 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 2801949..2802140 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 2801949..2802140 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 2802119 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2802167..2802652) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(2802167..2802652) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(2802675..2802986) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(2802675..2802986) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(2803038..2803130) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(2803038..2803130) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(2803170..2803189) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2803187) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2803203..2803210) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2803261..2803944) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(2803261..2803944) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(2803279) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(2803960..2805315) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(2803960..2805315) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(2805327..2805342) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2805343) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2805354..2805363) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2805617..2805624 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2805638..2805657 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2805641 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2805663..2805853 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 2805854..2807275 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 2805854..2807275 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 2807269 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2807349..2808899 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 2807349..2808899 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 2808943..2808949 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2808963..2808974 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2808963 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 2809007..2810569 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 2809007..2810569 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 2810547 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2810559..2811248 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 2810559..2811248 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 2810598..2810605 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2810619..2810638 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2810628 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 2811229 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(2811327) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 2811330..2811665 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 2811330..2811665 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 2811665..2811985 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 2811665..2811985 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 2811986..2812176 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(2812021..2812533) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(2812021..2812533) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 2812153 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2812569..2812580) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2812575) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2812595..2812601) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2812648..2812784) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(2812691) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(2812785..2814128) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(2812785..2814128) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(2814157..2814176) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2814165) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2814189..2814198) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2814190..2814195 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2814211..2814229 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2814214 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2814423..2814432 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2814441 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2814446..2814465 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2814484..2815446 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 2814484..2815446 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 2815447..2815700 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(2815727) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(2815731..2815806) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(2815731..2815806) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(2815833..2815852) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2815854) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2815868..2815871) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2815937..2815943 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2815953..2816028 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 2815953 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2815958..2815977 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2816005..2816012 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2816026..2816045 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2816030 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 2816076..2816669 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 2816076..2816669 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 2816658 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 2816703..2817101 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(2816715..2817395) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(2816715..2817395) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(2816739) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(2817392..2819077) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(2817392..2819077) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(2819070..2821343) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(2819070..2821343) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(2821321..2822205) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(2821321..2822205) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(2822211..2823047) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(2822211..2823047) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(2823048..2824355) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(2823048..2824355) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 2823413..2823422 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2823435..2823454 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2823439 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2824395..2825648) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(2824395..2825648) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(2825649..2825743) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(2825744..2827513) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(2825744..2827513) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 2827434..2827439 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2827455..2827473 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2827465 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2827551..2827570) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2827564) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2827583..2827590) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2827626..2828576) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(2827626..2828576) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(2828591..2828609) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2828604) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2828621..2828629) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2828710) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2828782..2829357) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(2828782..2829357) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(2828794) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2829400..2829419) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2829406..2829413 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2829416) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 2829423 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2829426..2829445 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2829434..2829441) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2829474..2829794 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 2829474..2829794 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 2829775 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2829821) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2829821..2831413) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(2829821..2831413) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(2831432..2832025) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(2831432..2832025) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(2832067..2832086) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2832080) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2832101..2832105) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2832151..2832156 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2832172..2832190 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2832173 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2832346..2832353 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2832367..2832386 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2832371 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 2832408..2833385 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 2832408..2833385 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 2833357 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2833423..2835363) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(2833423..2835363) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(2833447) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(2835338..2836117) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(2835338..2836117) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(2836118..2836199) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(2836200..2837270) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(2836200..2837270) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(2837264..2837977) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(2837264..2837977) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(2838023..2838042) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2838035) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2838037..2838298) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(2838055..2838058) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2838058..2838065 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2838076..2838095 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2838081 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2838124..2838333 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 2838124..2838333 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 2838311 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2838343) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2838369..2839133) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(2838369..2839133) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(2838391) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2839134..2839391) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(2839134..2839391) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(2839415..2840365) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(2839415..2840365) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(2840388..2841341) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(2840388..2841341) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(2841343..2842230) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(2841343..2842230) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(2842255..2842731) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(2842255..2842731) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(2842751..2842770) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2842765) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2842786..2842790) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2842809..2842828) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2842822) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2842843..2842846) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2842898..2843048) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(2842941) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(2843049..2843999) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(2843049..2843999) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(2844000..2844087) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(2844076..2844095) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2844087) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2844089..2844180) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(2844110..2844113) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2844128..2844134 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2844148..2844166 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2844162 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 2844163..2847549 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(2844205..2845626) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(2844205..2845626) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(2844225) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(2844349) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 2845253..2845257 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2845263 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2845542..2845546 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2845549 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2845627..2845824) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 2845747 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2845812..2845831) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(2845824) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(2845843..2845850) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(2846007..2847461) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(2846007..2847461) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(2846027) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(2847462..2847586) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 2847507 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2847587..2849356) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(2847587..2849356) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(2849357..2849431) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(2849420..2849439) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2849431) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(2849521..2849880) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(2849521..2849880) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(2849541) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2849895..2851805) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(2849895..2851805) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(2851807..2852349) /gene="yvcA" /locus_tag="PG10_pseudo_BSU_34850" /old_locus_tag="BSU_34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /modified_by="User" /translation="MVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGKNKE SIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKKTDI YTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDEEKA KNKVEKLINSITFLIDKKEK*" /label="PG10_pseudo_BSU_34850" gene complement(2851807..2852349) /gene="yvcA" /locus_tag="PG10_pseudo_BSU_34850" /old_locus_tag="BSU_34850" /modified_by="User" /label="PG10_pseudo_BSU_34850" N_region 2852408..2853457 /comment="Inserted sequence is a combination of three independent chromosomal regions. First the arabinose inducible mtlA promoter, second a copy of the original comK gene as well as third a copy of the original comS gene." /modified_by="User" /label="IIG_Bs27_024" promotor_-35 2852468..2852475 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2852489..2852508 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2852494 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" CDS 2852568..2853146 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 2852568..2853146 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" CDS 2853195..2853335 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 2853195..2853335 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" S_feature complement(<2853458..2853499) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" CDS complement(2853525..2854154) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(2853525..2854154) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(2853544) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(2854151..2854909) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(2854151..2854909) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(2854906..2855643) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(2854906..2855643) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(2855640..2856278) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(2855640..2856278) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 2856136..2856236 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2856196 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2856279..2856863) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(2856279..2856863) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(2856860..2858143) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(2856860..2858143) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(2858140..2858781) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(2858140..2858781) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(2858774..2859949) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(2858774..2859949) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(2859950..2860027) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 2859993..2859999 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2860011..2860030 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2860011..2860030) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2860024 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2860027) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2860043..2860050) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2860159..2860178 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2860166 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 2860200..2860952 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 2860200..2860952 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 2860953..2861191 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(2860974..2860985) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2860980) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2861000..2861006) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2861192..2861857 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 2861192..2861857 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 2861828 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2861877..2862395) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(2861877..2862395) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(2861911) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2862399..2863049) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(2862399..2863049) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(2863046..2863984) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(2863046..2863984) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(2864008..2864817) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(2864008..2864817) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(2864831..2865763) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(2864831..2865763) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(2865805..2865824) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2865811) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2865840..2865845) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2865880..2865887 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2865899 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2865902..2865919 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2865945..2867135 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 2865945..2867135 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 2866933..2866939 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2866954 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2866955..2866973 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2867132..2867860 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 2867132..2867860 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 2867878..2868609 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 2867878..2868609 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(2868629..2872498) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(2868629..2872498) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(2868751) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2872518..2872529) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872525) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2872544..2872550) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2872588..2872594 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2872608..2872627 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2872613 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 2872663..2873136 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 2872663..2873136 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 2873137..2873244 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(2873177..2874394) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(2873177..2874394) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(2873190) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2873216..2873221 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2873236..2873247 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2873246..2873531 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 2873246 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 2873488 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2874410..2875156) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(2874410..2875156) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(2875157..2875343) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(2875329..2875348) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2875343) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2875362..2875369) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2875477..2875484 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2875499..2875518 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2875511 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 2875512..2875581 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 2875582..2876091 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 2875582..2876091 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(2875987..2877325) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(2876028) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2876112..2877323 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 2876112..2877323 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 2877321 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(2877351..2877710) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(2877351..2877710) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 2877366..2878082 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(2877370) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2877712..2877909) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(2877712..2877909) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(2877914..2879011) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(2877914..2879011) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(2879036..2879362) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(2879036..2879362) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(2879415..2879430) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2879430) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2879432..2879922) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(2879442..2879451) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2879510..2879513 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2879528..2879547 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2879538 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 2879580..2879810 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 2879580..2879810 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(2879913..2879932) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(2879923) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(2879948..2879952) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(2880009..2880491) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(2880009..2880491) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 2880017 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(2880032) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2880164) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2880172..2880175) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2880252..2880256) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2880252) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2880272..2880275) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2880492..2880625) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(2880653..2883526) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(2880653..2883526) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(2880670) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2883534..2885519) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(2883534..2885519) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(2885553..2885572) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2885565) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2885567..2885652) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(2885584..2885591) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2885697) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(2885705..2885935) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(2885705..2885935) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(2885962..2885981) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(2885972) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(2885974..2886038) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(2885995..2886002) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(2886015..2886033) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2886036) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2886048..2886054) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2886104) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2886130..2886230) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2886170) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2886252..2886259 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2886273..2886292 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2886290 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2886382..2888877 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 2886382..2888877 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 2888892..2888896 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2888910 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 2888953..2889522 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 2888953..2889522 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 2889553..2890887 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 2889553..2890887 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 2890868 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(2890935..2892128) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(2890935..2892128) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(2890944) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(2891009) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2892129..2892206) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(2892132) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2892207..2892545) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(2892207..2892545) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(2892520..2892636) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(2892520..2892636) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(2892637..2892726) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(2892708..2892726) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2892726) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2892728..2892808) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(2892740..2892745) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2892794..2892812) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2892808) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2892826..2892833) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2892945..2894387) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(2892945..2894387) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(2893034) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2894433..2894444) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2894444) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2894459..2894465) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2894527..2895417) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(2894527..2895417) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(2894544) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(2895410..2896096) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(2895410..2896096) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(2896097..2896229) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(2896219..2896238) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2896229) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2896253..2896256) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2896330..2896668) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(2896330..2896668) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(2896331) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2896695..2896714) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(2896708) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(2896717..2897601) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(2896717..2897601) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(2896728..2896735) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(2897589..2897608) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(2897610) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(2897623..2897630) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(2898758..2898829), complement(2897728..2898756)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(2897728..2898829) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(2897744) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(2898830..2898898) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(2898899..2901424) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(2898899..2901424) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(2901425..2901505) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(2901495..2901514) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2901505) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2901592..2902161) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(2901592..2902161) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(2901600) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 2902128..2902134 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2902147..2902166 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2902154 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2902188..2902206) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2902196) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2902198..>2902299) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(2902218..2902226) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 2902299..2902300 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_008" CDS complement(2902303..2902785) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(2902303..2902785) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(2902801..2903067) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(2902801..2903067) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(2903068..2903147) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(2903148..2903567) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(2903148..2903567) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(2903606..2903624) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2903617) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2903638..2903645) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2903641..2904363) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(2903641..2904363) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(2904327..2904623) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(2904327..2904623) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(2904649..2904668) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2904662) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2904679..2904686) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2904683..2906074) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(2904683..2906074) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(2906088..2906107) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2906103) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2906121..2906128) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2906180..2907025) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(2906180..2907025) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(2906191) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2906442..2906449 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2906463..2906482 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2906473..2908205 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 2906473 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2907052..2907071) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2907071) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2907086..2907089) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2907123..2907812) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(2907123..2907812) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(2907137) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(2907813..2907894) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(2907895..2909052) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(2907895..2909052) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(2909053..2909180) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 2909100..2909103 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2909118..2909137 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2909129..2909215 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 2909129 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2909174..2909193) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2909180) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2909197..2909205 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2909204..2909211) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2909217 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2909219..2909227 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2909269..2909922 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 2909269..2909922 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(2909625..2910217) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 2909922..2911097 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 2909922..2911097 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(2910213..2910231) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2910222) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2910245..2910251) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2911069 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2911170..2912246) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(2911170..2912246) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(2911186) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2911232..2911241 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2911255..2911274 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2911263..2912496 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 2911263 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2912247..2912329) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(2912317..2912336) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2912329) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2912348..2912354) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2912391..2913584) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(2912391..2913584) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(2912421) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(2913613..2914371) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(2913613..2914371) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(2914395..2915075) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(2914395..2915075) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(2915104..2916570) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(2915104..2916570) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(2916571..2916654) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(2916655..2918040) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(2916655..2918040) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(2918102..2919271) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(2918102..2919271) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(2919268..2920719) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(2919268..2920719) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(2920775..2920924) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(2920775..2920924) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(2920869..2921408) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(2920869..2921408) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(2921464..2921481) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2921468) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2921635..2923125) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(2921635..2923125) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(2921657) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2923164..2925281) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(2923164..2925281) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(2925305..2925613) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(2925305..2925613) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 2925519 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 2925609..2925613 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2925622..2925636 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2925623..2925641) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2925629 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2925655..2925662) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2925658) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2925679..2925687 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2925701..2925714 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2925719 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 2925797..2926717 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 2925797..2926717 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 2926707 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2926757..2927899) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(2926757..2927899) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(2926781) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2927938..2927957) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2927952) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2927972..2927975) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2928028..2928032 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2928048..2928067 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2928049..2928144 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 2928050 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 2928145..2929023 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 2928145..2929023 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 2929024..2930115 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(2929093..2929448) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 2929357..2929575 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 2929357..2929575 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(2929449..2929532) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(2929449..2929532) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(2929533..2929724) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(2929725..2932427) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(2929725..2932427) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(2932428..2932550) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 2932449..2932455 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2932470..2932488 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2932475..2935307 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 2932475 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2932551..2933891) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(2932551..2933891) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(2933932..2934138) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(2933932..2934138) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(2934139..2935012) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(2935006..2935025) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2935012) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2935014..2935253) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(2935038..2935044) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2935235..2935253) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(2935253) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(2935267..2935274) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 2935276..2935283 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2935295..2935314 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2935309..2935439 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 2935309 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 2935381..2935481 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2935441 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2935445..2936041 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 2935445..2936041 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 2935639 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2936080..2937663) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(2936080..2937663) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 2936123 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(2937683..2938510) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(2937683..2938510) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(2938511..2938575) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(2938571..2938590) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2938575) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2938577..2938674) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(2938606..2938609) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2938675..2940915) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(2938675..2940915) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(2940915..2942936) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(2940915..2942936) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 2941678..2941687 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2941700..2941715 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2941711 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2942937..2943096) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(2943097..2943486) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(2943097..2943486) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(2943487..2943621) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(2943605..2943624) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2943621) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2943635..2943642) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2943776..2943782 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2943793..2943885 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 2943793 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2943794..2943813 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2943886..2944656 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 2943886..2944656 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(2944013..2944361) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(2944365..2944376) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2944369) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2944391..2944397) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2944681 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 2944689..2945834 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 2944689..2945834 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 2945822 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 2945876..2945883 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2945898..2945917 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2945908 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 2945954..2947282 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 2945954..2947282 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 2947277 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2947338) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR 2947362..2947363 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_002" downshifts 2947386 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2947439..2948680) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(2947439..2948680) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(2947458) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2948702..2948720) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2948724) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2948733..2948740) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2948821..2948988) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(2948821..2948988) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(2948848) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(2949003..2950145) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(2949003..2950145) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(2950164..2950613) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(2950164..2950613) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 2950307..2950313 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 2950321 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 2950327..2950345 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 2950334..2952543 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(2950628..2951809) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(2950628..2951809) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 2952523..2952530 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2952545 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2952546..2952565 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2952566) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2952571..2952585) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2952593..2952597) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2952593..2953573 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 2952593..2953573 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 2953422..2953429 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2953443..2953462 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2953458 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 2953575..2954456 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 2953575..2954456 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 2954453..2954848 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 2954453..2954848 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 2954864..2956345 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 2954864..2956345 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 2956347..2957315 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 2956347..2957315 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 2957327..2958244 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 2957327..2958244 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 2958253..2958259 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2958274..2958292 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2958276 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 2958326..2958862 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 2958326..2958862 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 2958845 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 2958890..2959000 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 2958969..2958975 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2958990..2959001 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2959002 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 2959018..2959314 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 2959018..2959314 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 2959315..2959967 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(2959354..2959881) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(2959354..2959881) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(2959364) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2959901..2959920) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2959914) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 2959925 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2959934..2959941) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2959980) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(2959981..2960748) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(2959981..2960748) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(2960810..2962522) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(2960810..2962522) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 2961421..2961430 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2961444..2961463 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2961444 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2962576..2962595) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2962581) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2962601..2962608 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2962610..2962614) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2962622..2962641 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2962632 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 2962680..2963588 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 2962680..2963588 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 2963656..2963664 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2963666..2963798 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 2963666 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2963678..2963697 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2963799..2965127 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 2963799..2965127 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 2965118 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2965184..2965861) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(2965184..2965861) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(2965194) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2965921..2967063) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(2965921..2967063) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(2967100..2967119) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2967108) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2967110..2967190) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(2967133..2967141) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2967191..2968279) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(2967191..2968279) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(2968280..2968393) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 2968335..2968344 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2968357..2968376 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2968370 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2968393) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2968397..2968411) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2968420..2968424) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2968420..2969007 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 2968420..2969007 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 2968508..2968987 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 2968508..2968987 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(2968891..2969088) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 2968924 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(2968934) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 2968993 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 2969072 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2969087..2969106) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2969093) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2969115..2969122 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2969119..2969128) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2969137..2969156 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2969143 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 2969181..2969798 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 2969181..2969798 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 2969799..2969899 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 2969856 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 2969925..2969934 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2969946..2969961 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2969947 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2969976..2970311 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 2969976..2970311 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(2970267..2970285) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2970276) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2970300..2970305) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2970310 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2970316..2971893) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(2970316..2971893) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 2970355..2972066 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 2972044..2972051 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2972062..2972081 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2972068 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2972107..2972583 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 2972107..2972583 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 2972597..2973190 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 2972597..2973190 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 2973187..2973723 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 2973187..2973723 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 2973704 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(2973750..2973971) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(2973750..2973971) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 2973918 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2973925..2973926 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2973968..2974513) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(2973968..2974513) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 2974530..2974537 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2974552..2974571 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2974556 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 2974636..2975517 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 2974636..2975517 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(2975602..2976318) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(2975602..2976318) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(2975622) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2976328..2976792) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(2976328..2976792) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(2976782..2978590) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(2976782..2978590) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(2978609..2978869) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(2978609..2978869) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(2978879..2979301) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(2978879..2979301) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(2979302..2979384) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(2979376..2979395) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2979384) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2979408..2979415) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2979518..2979643) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(2979518..2979643) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(2979561..2979692) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(2979604) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2979693..2980478) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(2979693..2980478) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(2980479..2980594) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(2980587..2980606) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2980594) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2980620..2980627) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2980670..2981992) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(2980670..2981992) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(2980682) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2982026) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2982028..2982153) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(2982028..2982046) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2982062..2982067) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2982133..2982152) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2982153) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2982187..2982951) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(2982187..2982951) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(2982970) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2983004..2983717) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(2983004..2983717) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(2983021) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(2983707..2984453) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(2983707..2984453) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(2984485..2984504) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2984497) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2984521..2984524) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2984687..2984830) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(2984687..2984830) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(2984708) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2984831..2984916) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(2984906..2984917) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2984916) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2984918..2985148) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 2984955..2984959 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2984975..2984994 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2984984 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 2985034..2986644 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 2985034..2986644 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(2985136..2985154) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2985148) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2985150..2985324) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(2985168..2985175) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2985311..2985330) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2985324) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2985344..2985352) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2986631..2989399 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 2986631..2989399 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(2989448) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(2989525..2990382) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(2989525..2990382) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(2990388..2991164) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(2990388..2991164) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(2991190..2991209) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2991212) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2991214..2991286) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(2991224..2991231) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2991288..2991387) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(2991331) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2991388..2991729) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(2991388..2991729) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(2991751..2991770) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2991770) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2991784..2991791) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2991806..2992189) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(2991806..2992189) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(2992211..2992230) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 2992218..2992237 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2992222 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2992231) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(2992245..2992252) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 2992312..2992331 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2992315 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2992364) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 2992364..2992774 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 2992364..2992774 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 2992775..2992858 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 2992816 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2992914..2993222) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(2992914..2993222) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(2992915) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 2993566..2994402 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 2993566..2994402 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 2993782..2993789 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2993804..2993823 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2993807 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2994401 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(2994449..2994841) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(2994449..2994841) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(2994455) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2994914..2995339) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(2994914..2995339) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(2995400..2995419) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2995416) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2995418..2995502) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(2995434..2995441) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2995481 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2995484..2995503 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2995494..2995513) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(2995502) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(2995504..2996588) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(2995527..2995532) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 2995531..2996595 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 2995531..2996595 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 2996596..2997480 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(2996618..2997427) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(2996618..2997427) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(2996633) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2997461..2998273) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(2997461..2998273) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(2998274..2998353) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 2998304..2998311 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2998325..2998344 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2998334 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2998347..2998365) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(2998353) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(2998379..2998386) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(2998436..2999437) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(2998436..2999437) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(2998442) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(2999492..2999511) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2999516) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(2999518..2999602) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(2999603..2999884) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(2999603..2999884) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(2999899..3000009) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(2999899..3000009) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3000040..3000058) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3000062) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3000074..3000079) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3000155..3000161 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3000175..3000194 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3000191 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3000234..3000647 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3000234..3000647 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3000669..3001859 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3000669..3001859 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3001950..3003356) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3001950..3003356) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3002247) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3003389..3003408) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3003407) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3003423..3003426) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3003462..3004934) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3003462..3004934) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3005115..3006473) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3005115..3006473) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3005129) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3006473..3007042) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3006473..3007042) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3007061..3007072) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3007079) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3007086..3007092) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3007149..3007316) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3007149..3007316) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3007226..3007690) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3007226..3007690) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3007720..3007739) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3007725) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3007753..3007760) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3007891..3007894 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3007909..3007928 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3007913 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3007972..3009186 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3007972..3009186 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3008802..3008820) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3008803) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3008834..3008841) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3009052..3009058 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3009072..3009091 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3009074 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3009198..3009548 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3009198..3009548 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3009541 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3009600..3009608 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3009622..3009630 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3009629 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3009671..3009680 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3009693..3009708 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3009697 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3009729..3010310 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3009729..3010310 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3009827..3009846) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3009837) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3009860..3009868) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3010291 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3010351..3010773) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3010351..3010773) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3010370) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3010808..3010823) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3010827) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3010836..3010845) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3010884..3011735) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3010884..3011735) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3010893) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3011135) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3011372..3011374 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3011391..3011410 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3011392..3011738 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3011392 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3011730..3011733 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3011740..3011875 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3011740 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3011769) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3011775..3011784) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3011876..3012367 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3011876..3012367 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3012105..3012110 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3012126..3012144 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3012137 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3012228..3013136) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3012364..3012882 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3012364..3012882 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3012687 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3012885 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3013041..3013172 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3013041..3013172 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3013169..3013603) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3013169..3013603) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3013181) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3013652..3013671) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3013659) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3013661..3013958) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3013686..3013693) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3013732..3013736 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3013753..3013772 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3013765..3013845 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3013766 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3013846..3015294 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3013846..3015294 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3013958) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3013959..3013977) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3013960..3014303) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3013993..3013999) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3014281..3014299) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3014303) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3014315..3014320) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3015283 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3015315..3016088) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3015315..3016088) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3015337) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3016163..3016166 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3016182..3016201 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3016186 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3016233..3016616 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3016233..3016616 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3016603 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3016651..3017292) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3016651..3017292) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3016701) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3017360..3017761) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3017360..3017761) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3017810..3017829) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3017820) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3017822..3017895) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3017844..3017849) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3017896..3019605) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3017896..3019605) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3019602..3019976) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3019602..3019976) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3019973..3020290) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3019973..3020290) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3020291..3020375) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3020375) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3020377..3020390) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3020377..3020470) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3020471..3020635) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3020471..3020635) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3020558..3020576) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3020570) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3020588..3020596) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3020636..3020807) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3020808..3020990) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3020808..3020990) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3020991..3021137) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3021125..3021144) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3021137) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3021139..3021253) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3021159..3021166) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3021240,3021242) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3021267 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3021270..3021274 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3021287..3021475) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3021287..3021475) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3021298) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3021465 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3021501..3021519) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3021512) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3021533..3021539) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3021548..3022048) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3021548..3022048) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3022084..3022103) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3022091) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3022117..3022123) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3022183..3023316) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3022183..3023316) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3022201) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3023343..3023362) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3023350) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3023413..3023431) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3023429) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3023445..3023452) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3023508..3024533) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3023508..3024533) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3023521) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3024549..3025337) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3024549..3025337) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3025363..3025382) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025369) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3025371..3025582) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3025396..3025403) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3025583..3025744) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3025583..3025744) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3025757..3025775) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3025777) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3025789..3025795) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3025838..3026512) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3025838..3026512) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3025853) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3026565..3026705) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3026565..3026705) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3026836..3027519) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3026836..3027519) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3027896..3027900 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3027905..3028936) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3027905..3028936) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3027915..3027934 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3027921) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3027933 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3028964..3028982) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3028977) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3028979..3029096) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3028998..3029003) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3029038..3029043 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3029055..3031715 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3029055 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3029059..3029077 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3029132..3030442) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3029132..3030442) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3029141) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3030466..3030485) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3030473) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3030476..3031216) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3030476..3031216) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3030499..3030508) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3030847) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3030849..3030857) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3030871..3030879) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3030971..3030986) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3030979) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3030999..3031008) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3031217..3031344) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3031345..3031575) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3031345..3031575) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3031576..3031838) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3031711..3031730 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3031717 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3031745..3032218 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3031745..3032218 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3031822..3031841) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3031838) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3031840..3032223) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3031856..3031859) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3032252..3032650) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3032252..3032650) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3032268) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3032642..3032660) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3032651) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3032674..3032680) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3032674..3034095) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3032674..3034095) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3034121..3034984) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3034121..3034984) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3034985..3035060) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3035061..3036569) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3035061..3036569) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3036586..3037131) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3036586..3037131) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3037128..3037640) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3037128..3037640) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3037641..3037802) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3037803..3038015) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3037803..3038015) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3038061..3038795) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3038061..3038795) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3038609..3038709 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3038669 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3038803..3039186) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3038803..3039186) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3038875..3038893) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3038877) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3039187..3039457) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3039419..3039428 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3039428 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3039433..3039452) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3039442..3039461 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3039457) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3039459..3039580) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3039465..3039472) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3039609..3040238) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3039609..3040238) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3039625) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3040282..3040301) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3040305) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3040316..3040323) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3040373..3041620) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3040373..3041620) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3040396) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3041662..3041681) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3041679) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3041681..3041765) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3041696..3041701) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3041810) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3041827..3042369) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3041827..3042369) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3042382..3042831) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3042382..3042831) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3042832..3042931) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3042923..3042942) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3042931) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3042956..3042963) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3042988..3043440) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3042988..3043440) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3043457..3043476) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3043475) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3043491..3043494) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3043516..3044073) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3043516..3044073) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3044100..3044118) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3044113) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3044134..3044139) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3044152..3045192) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3044152..3045192) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3044157) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3045193..3045257) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3045247..3045266) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3045257) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3045259..3045348) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3045282..3045286) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3045349..3045792) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3045349..3045792) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3045859..3046533) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3045859..3046533) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3046295..3046313) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3046302) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3046328..3046334) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3046565..3046582) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3046566) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3046598..3046603) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3046639 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3046643..3046662 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3046674..3047036 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3046674..3047036 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3047049) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3047053..3047340) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3047053..3047340) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3047341..3047399) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3047397..3047416) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3047400..3048266) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3047400..3048266) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3047413) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3047429..3047438) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3048268..3049338) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3048268..3049338) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3048271) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3049339 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3049366..3049385) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3049390) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3049392..3049503) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3049399..3049405) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3049435..3049454 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3049449 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3049464..3049850 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3049464..3049850 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3049485..3049503) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3049503) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3049517..3049524) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3049918..3049926 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3049937..3049955 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3049938 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3049972..3050526 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3049972..3050526 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3050456..3050460 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3050461 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3050505 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3050560..3051519) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3050560..3051519) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3050582) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3051557..3051575) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3051571) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3051590..3051596) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3051601..3053349) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3051601..3053349) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3052075..3052093) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3052083) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3052108..3052114) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3053350..3053440) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3053424..3053443) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3053440) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3053457..3053464) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3053583) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3053588..3054175) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3053588..3054175) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3054264..3054464) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3054264..3054464) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3054277) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3054465..3054542) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3054538..3054557) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3054542) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3054571..3054578) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3054583..3055866) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3054583..3055866) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3055867..3056169) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3055897..3056058) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3055897..3056058) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3056149..3056168) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3056169) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3056184..3056188) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3056273..3057238) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3056273..3057238) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3056279) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3056855..3056864 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3056877..3056896 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3056885 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3057269..3058558) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3057269..3058558) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3058559..3058918) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3058937..3059575) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3058937..3059575) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3058963) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3059576..3059694) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3059695..3060552) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3059695..3060552) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3060553..3060679) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3060661..3060680) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3060679) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3060694..3060701) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3060733..3061107) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3060733..3061107) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3061147..3061165) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3061161) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3061163..3061802) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3061164..3061167 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3061176..3061184) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3061183..3061202 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3061196 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3061210..3061215 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3061231..3061250 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3061241 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3061273..3061794 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3061273..3061794 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3061737..3061740 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3061755..3061774 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3061769 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3061792..3061811) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3061802) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3061813 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3061826..3061833) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3061876..3063483) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3061876..3063483) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3061889) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3063484..3063671) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3063659..3063678) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3063671) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3063693..3063700) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3063725..3064246) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3063725..3064246) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3063781) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3064247..3064349) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3064330..3064349) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3064349) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3064351..3064428) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3064365..3064368) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3064429..3065568) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3064429..3065568) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3065565..3067682) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3065565..3067682) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3067683..3067741) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3067742..3067761) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3067755) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3067775..3067782) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3067781..3067787 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3067801..3067812 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3067806 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3067837..3069033 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3067837..3069033 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3068029..3068907) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3068897..3068915) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3068908) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3068931..3068936) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3069046..3070008 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3069046..3070008 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3070022..3070028 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3070043..3070061 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3070043 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3070089..3070361 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3070089..3070361 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3070095) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3070351 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3070396..3070802 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3070403..3070927) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3070403..3070927) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3070425) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3070937..3072664) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3070937..3072664) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3072698..3072717) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3072712) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3072731..3072737) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3072753..3074255) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3072753..3074255) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3074279..3074297) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3074297) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3074312..3074318) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3074342..3074714) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3074385) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3074741..3075412) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3074741..3075412) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3074759) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3075409..3075963) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3075409..3075963) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3075989..3077452) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3075989..3077452) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3077442..3081128) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3077442..3081128) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3081159..3081178) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3081183) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3081185..3081314) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3081324..3081800) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3081324..3081800) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3081359) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3081823..3081842) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3081835) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3081857..3081860) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3081907 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3081910..3081929 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3081944..3082663 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3081944..3082663 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3082647 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3082695..3083411) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3082695..3083411) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3082697) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3082767) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3083437..3083456) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3083449) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3083510..3084697) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3083510..3084697) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3084727..3084746) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3084745) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3084833..3086503) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3084833..3086503) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3084835) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3086500..3086928) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3086500..3086928) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3086996..3087010 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3086996..3087015) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3087003 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3087012) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3087032..3087035) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3087067..3087086) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3087079) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3087108,3087115) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3087109..3087114 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3087115..3089593 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3087116..3088492) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3087116..3088492) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3088531..3089886) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3088531..3089886) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3089922..3089941) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3089940) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3089954..3089963) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3090066..3090085 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3090067 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3090112) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3090116..3091261 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3090116..3091261 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3091120..3091124 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3091141..3091160 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3091148 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3091231) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3091245..3091364 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3091245..3091364 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3091349 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3091394..3091462 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3091463..3091936 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3091463..3091936 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3091925 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3091968..3092840) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3091968..3092840) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3091979) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3092045) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3092901..3093731) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3092901..3093731) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3093732..3093827) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3093815..3093834) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3093826) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3093847..3093854) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3093872..3093877 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3093893..3093911 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3093895 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3093933..3096008 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3093933..3096008 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3096061) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3096185..3096300) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3096228) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3096301..3096819) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3096301..3096819) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3096833..3097492) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3096833..3097492) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3097515..3097518 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3097528..3097547) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3097533..3097552 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3097536 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3097546) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3097548..3097831) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3097562..3097569) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3097601..3097789 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3097601..3097789 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3097778 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3097832..3098251) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3097832..3098251) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3098301..3098320) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3098312) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3098335..3098342) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3098371..3100287) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3098371..3100287) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3099565..3099583) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3099570) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3099600..3099604) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3100318) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3100341..3100562) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3100341..3100562) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3100594..3100815) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3100594..3100815) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3100847..3101109) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3100858 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3100890) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3100897..3101052) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3100897..3101052) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3101059..3101062 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3101071..3101084 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3101078 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3101086..3101105) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3101109) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3101119..3101125) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3101132..3102532) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3101132..3102532) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3102532..3103002) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3102532..3103002) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3102958) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3103114..3103614) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3103114..3103614) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3103117) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3103650..3104951) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3103650..3104951) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3104975..3104994) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3104989) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3104991..3105112) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3105010..3105012) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3105113..3105337) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3105113..3105337) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3105338..3105422) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3105411..3105430) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3105421) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3105445..3105448) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3105488..3105494 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3105509..3105520 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3105510 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3105552..3106328 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3105552..3106328 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3106314 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3106416..3106423 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3106438..3106457 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3106442..3110668 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3106442 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3106472..3107362) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3106472..3107362) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3107362..3107462) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3107402) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3107530..3108375) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3107530..3108375) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3107693) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3108424..3109323) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3108424..3109323) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3109366..3109385) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3109369) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3109399..3109406) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3109470) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3109470..3110441) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3109470..3110441) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3110476..3110495) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3110501) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3110511..3110515) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3110589..3110600) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3110592) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3110614..3110620) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3110663..3110682 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3110670 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3110711..3111475 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3110711..3111475 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3111462 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3111482,3111489) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3111483..3111488 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3111489..3111541 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3111491..3112729) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3111491..3112729) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3112771..3112790) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3112783) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3112802..3112809) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3112939..3114351) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3112939..3114351) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3112946) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3114351..3116051) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3114351..3116051) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3115020..3115036) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3115032) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3116125..3117672) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3116125..3117672) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3116132) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3117716) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3117718..3117898) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3117719..3117737) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3117899..3119173) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3117899..3119173) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3119174..3119256) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3119256) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3119269..3119287) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3119349) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3119350..3119814) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3119350..3119814) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3119815..3119925) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3119907..3119926) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3119925) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3119941..3119948) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3120136) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3120138..3120593) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3120138..3120593) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3120228..3120247 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3120236 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3120586..3121437) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3120586..3121437) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3121451..3122398) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3121451..3122398) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3122398..3123138) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3122398..3123138) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3123156..3123161 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3123162 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3123163..3124182) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3123163..3124182) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3123176..3123194 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3124046..3124055 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3124068..3124083 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3124079 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3124185..3124907) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3124185..3124907) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3124900..3126021) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3124900..3126021) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3126021..3126890) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3126021..3126890) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3126891..3128060) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3126891..3128060) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3128081..3129505) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3128081..3129505) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3129510..3130280) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3129510..3130280) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3130315..3130334) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3130329) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3130348..3130357) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3130448..3130453 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3130469..3130487 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3130471..3130599 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3130471 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3130600..3131145 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3130600..3131145 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3131131 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3131189..3131560) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3131189..3131560) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3131207) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3131622..3132944) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3131622..3132944) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3132964..3133281) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3132964..3133281) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3133310..3133329) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3133321) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3133343..3133349) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3133384..3133391 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3133407..3133426 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3133410 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3133449..3134819 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3133449..3134819 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3134844..3135521) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3134844..3135521) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3134858) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3135348..3135367) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3135364) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3135383..3135388) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3135535..3136341) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3135535..3136341) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3135834..3135852) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3135848) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3135867..3135873) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3136370..3136389) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3136376) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3136405..3136412) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3136431..3136964) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3136431..3136964) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3137012..3137647) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3137012..3137647) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3137640..3137978) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3137640..3137978) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3138000..3138019) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3138011) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3138034..3138041) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3138062..3138065 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3138080..3138099 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3138080 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3138122..3138937 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3138122..3138937 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3138916 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3138992) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3139027..3139275) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3139027..3139275) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3139047) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3139293) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3139295..3139368) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3139303..3139309) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3139369..3140808) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3139369..3140808) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3140805..3142190) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3140805..3142190) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3142209..3142218) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3142223) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3142225..3142289) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3142268..3142285) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3142289) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3142301..3142308) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3142331..3142350) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3142349) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3142364..3142371) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3142430..3142433 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3142440 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3142448..3142467 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3142492..3143262 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3142492..3143262 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3143263..3144330 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3143301..3144131) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3143301..3144131) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3143302) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3144157..3144176) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144163) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3144171..3144473) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3144171..3144473) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3144191..3144198) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3144474..3144612) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3144597..3144616) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3144612) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3144927..3144935 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3144946..3144964 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3144947 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3145003..3145080 /gene="vpr" /old_locus_tag="BSU_38090" /created_by="User" /modified_by="User" /transl_table=11 /locus_tag="PG10_BSU_38090-3'_ext" /translation="MKKGISQQTPPAISDTIGAYLQNDA*" /label="PG10_BSU_38090-3'_ext" gene 3145003..3145080 /gene="vpr_3'-chimera" /old_locus_tag="BSU_38090" /created_by="User" /locus_tag="PG10_BSU_38090-3'_ext" /label="PG10_BSU_38090-3'_ext" SCAR 3145013..3145014 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_017" CDS complement(3145016..3146017) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3145016..3146017) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3146018..3146179) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3146191..3146940) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3146191..3146940) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3146224) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3146958..3146977) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3146975) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3146992..3146995) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3147046..3148227) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3147046..3148227) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3147060) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3148228..3148359) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3148353..3148368) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3148359) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3148380..3148389) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3148594..3148601 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3148612..3148722 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3148612..3148631 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3148612 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3148723..3148986 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3148723..3148986 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3148876 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3148992 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3149029..3149403) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3149029..3149403) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3149040) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3149405..3150019) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3149405..3150019) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3150033..3151982) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3150033..3151982) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3151246..3151265 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3151252 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3151676..3151776 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3151736 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3151846 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3152010..3152975) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3152010..3152975) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3152976..3153044) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3153031..3153050) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3153044) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3153046..3153231) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3153063..3153067) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3153162..3153167 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3153183..3153201 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3153188 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3153222..3153241) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3153231) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3153233..3153342) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3153256..3153260) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3153298 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3153327..3153346) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3153342) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3153362..3153366) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3153420..3153438) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3153425..3153431 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3153437) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3153446..3153464 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3153449 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3153454..3153459) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3153491..3153736 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3153491..3153736 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3153718 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3153807..3155348) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3153807..3155348) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3153836) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3155352..3156524) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3155352..3156524) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3156542..3156560) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3156564) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3156575..3156581) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3156605..3156988) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3156605..3156988) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3157006..3157677) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3157006..3157677) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3157699..3157718) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3157708) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3157734..3157737) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3157818..3157821 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3157836..3157855 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3157845..3158032 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3157845 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3158033..3158191 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3158033..3158191 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3158192..3158576 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3158557..3158562 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3158578..3158596 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3158578 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3158634..3158942 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3158634..3158942 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3158720) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3158724..3158824) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3158764) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3158939..3160480 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3158939..3160480 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3160471 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3160511..3161113) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3160511..3161113) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3160525) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3161114..3161395) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3161396..3162646) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3161396..3162646) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3161492) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3162665..3163822) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3162665..3163822) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3162738..3162757) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3162765) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3163819..3165264) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3163819..3165264) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3165298..3165317) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3165308) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3165331..3165338) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3165421..3166089) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3165421..3166089) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3165430) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3166086..3166904) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3166086..3166904) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3166912..3167817) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3166912..3167817) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3167552..3167571) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3167563) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3167858..3167877) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3167868..3167875 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3167879) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3167887 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3167889..3167908 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3167893..3167900) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3167923..3168309 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3167923..3168309 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3168291..3168968 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3168291..3168968 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3168940 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3169012..3169019 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3169030 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3169033..3169052 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3169072..3170271 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3169072..3170271 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3170305..3170502 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3170305..3170502 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3170481 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3170537..3171727) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3170537..3171727) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3170552) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3170636) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3171751..3171770) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3171767) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3171787..3171794 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3171803 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3171808..3171827 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3171848..3172228 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3171848..3172228 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3172126 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3172197 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" downshifts complement(3172273) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3172288..3172289 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_020" promotor_-35 <3172289..3172292 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3172307..3172326 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3172326 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3172538..3172545 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3172558..3172577 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3172558 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3172610..3173989 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3172610..3173989 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3173698..3174901) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3174043..3174885 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3174043..3174885 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3174936..3175796) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3174936..3175796) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3174946) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3175780 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3175818..3175836) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3175836) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3175851..3175857) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3175906..3176619) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3175906..3176619) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3176021..3176022 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3176042..3176059 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3176044 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3176647..3176658) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3176648) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3176673..3176679) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3176694..3176700 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3176715..3176734 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3176725 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3176770..3177285 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3176770..3177285 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3177286..3177492 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3177286..3177492 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3177452 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3177534..3178775 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3177534..3178775 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3178866..3178874 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3178885..3178903 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3178896 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3178931..3180298 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3178931..3180298 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3180275 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3180328..3180960) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3180328..3180960) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3180346) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3180996..3181011) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3181004) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3181024..3181032) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3181102..3182037) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3181102..3182037) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3181114) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3181781..3181790 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3181804..3181823 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3181808 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3182038..3182125) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3182108..3182127) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3182125) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3182143..3182147) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3182170..3182182) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3182170) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3182197..3182203) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3182200..3182334) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3182200..3182334) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3182281..3182288 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3182302..3182321 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3182311 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3182314..3182418 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3182413..3182422 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3182420 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3182434..3182449 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3182456) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3182458..3182472) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3182484..3182633 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3182484..3182633 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3182651..3184162 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3182651..3184162 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3184159..3185346 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3184159..3185346 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3185363..3185599 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3185363..3185599 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3185599..3186777 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3185599..3186777 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3186778..3186867 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3186868..3187626 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3186868..3187626 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3187594 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3187628..3188855) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3187674..3187681 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3187695..3187714 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3187708 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3187767..3188858 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3187767..3188858 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3188760 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3188848 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3188892..3190220) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3188892..3190220) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3188900) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3190217..3190549) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3190217..3190549) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3190568..3191926) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3190568..3191926) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3191942..3192250) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3191942..3192250) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3192295..3192314) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3192311) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3192328..3192334) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3192379) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3192379..3194304) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3192379..3194304) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3193042..3193051 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3193065..3193084 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3193073 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3194377..3194394) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3194401) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3194409..3194416) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3194467..3194625) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3194467..3194625) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3194494) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3194654..3195244) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3194654..3195244) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3195272..3195290) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3195283) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3195304..3195310) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3195313..3195319 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3195335..3195353 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3195338 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3195373..3197016 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3195373..3197016 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3195510..3197059) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3197011 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3197061..3197152) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3197063..3197069 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3197077 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3197084..3197103 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3197104) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3197121..3198323 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3197121..3198323 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3197154..3198319) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3197197) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3198320..3199096) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3198320..3199096) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3199093..3199980) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3199093..3199980) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3199987..3200175) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3199987..3200175) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3200172..3200378) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3200172..3200378) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3200375..3200695) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3200375..3200695) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3200508..3200517 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3200530..3200549 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3200532 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3200688..3201224) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3200688..3201224) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3201252) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3201253..3201268) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3201280..3201289) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3201355..3201362 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3201376..3201395 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3201385 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3201436..3202809 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3201436..3202809 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3201716..3202258) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3202246..3202265) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3202258) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3202280..3202287) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3202644 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3202824..3203654) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3202824..3203654) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3202830) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3203673..3203691) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3203688) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3203706..3203712) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3203732) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3203734..3203753) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3203740..3205467) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3203740..3205467) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3203839) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3205464..3207167) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3205464..3207167) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3207167..3208183) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3207167..3208183) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3208057..3208075) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3208066) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3208091..3208096) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3208167..3209573) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3208167..3209573) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3209574..3209782) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3209765..3209784) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3209782) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3209784..3209892) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3209798..3209803) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3209889..3209908) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3209904) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3209922..3209929) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3210050..3210057 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3210067 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3210072..3210090 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3210129..3211481 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3210129..3211481 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3211080..3213562) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3211466 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3211557..3211576 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3211563 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3211603..3213291 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3211603..3213291 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3213289..3213298 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3213310..3213325 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3213314 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3213349..3213549 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3213349..3213549 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3213550..3214494 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3213563..3214402) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3213563..3214402) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3214428..3214446) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3214446) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3214459..3214466) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3214461 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3214509..3215606) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3214509..3215606) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3214510) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3215639..3215658) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3215656) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3215658..3215726) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3215671..3215678) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3215727..3216620) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3215727..3216620) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3216647..3216666) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3216666) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3216680..3216687) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3216694..3216699 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3216715..3216733 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3216724 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3216741..3216747 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3216762..3216780 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3216768 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3216804..3218261 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3216804..3218261 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3217687..3217705) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3217702) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3217720..3217725) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3218242 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3218286 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3218303..3219139) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3218303..3219139) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3218321) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3219216..3219318) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3219216..3219318) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3219242) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3219344..3219363) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3219355) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3219357..3220098) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3219377..3219383) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3219435..3219442 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3219455..3219473 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3219464 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3219474..3219559 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3219535..3219542 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3219556..3219575 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3219561 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3219707..3220249 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3219707..3220249 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3220074..3220093) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3220098) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3220107..3220116) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3220239 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3220284..3220606 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3220324..3221343) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3220324..3221343) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3220342) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3221369..3221388) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3221383) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3221403..3221406) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3221458..3221964) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3221458..3221964) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3221970..3221989) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3221992) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3221994..3221997 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3222003..3222009) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3222012..3222031 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3222015 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3222094..3222969 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3222094..3222969 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3222344..3222432) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3222366) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3222392..3222492) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3222432) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3223047..3223520 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3223047..3223520 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3223538..3224758 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3223538..3224758 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3224745..3225401 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3224745..3225401 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3225399..3225404 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3225418..3225437 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3225421 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3225451..3226683 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3225451..3226683 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3225468) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3226668 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3226729..3226738 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3226751..3226766 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3226753..3226975 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3226753 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3226932 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3226986..3226992 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3227005..3227105 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3227005 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3227007..3227025 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3227084..3227091 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3227105..3227123 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3227107..3227204 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3227107 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3227205..3227468 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3227205..3227468 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3227232..3227235 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3227250..3227269 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3227262 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3227416 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3227460 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3227535..3227544 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3227550 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3227556..3227571 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3227597..3228085 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3227597..3228085 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3228090..3228097 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3228111..3228130 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3228121 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3228151..3228257 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3228151..3228257 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3228252 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3228340..3229473 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3228340..3229473 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3228613..3228856) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3228851..3228870) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3228860) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3228885..3228892) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3229479..3229486 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3229501..3229520 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3229507 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3229542..3229648 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3229542..3229648 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3229595 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3229649..3229725 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3229726..3230862 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3229726..3230862 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3230849 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3230915..3231688) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3230915..3231688) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3230925) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3231705..3232355) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3231705..3232355) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3232352..3233068) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3232352..3233068) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3233092..3234510) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3233092..3234510) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3233678..3233696) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3233697) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3233712..3233717) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3234511..3234595) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3234579..3234597) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3234595) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3234613..3234618) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3234664..3235512) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3234664..3235512) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3234674) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3235513..3235698) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3235687..3235706) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3235698) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3235700..3236425) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3235722..3235726) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3235860..3235867 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3235880..3235899 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3235889 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3235899..3236001 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3235899..3236001 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3236002..3236105 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3236077..3236083 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3236097..3236108 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3236107 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3236128..3237321 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3236128..3237321 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3236412..3236430) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3236428) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3236443..3236450) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3237097 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3237317 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3237363..3237791) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3237363..3237791) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3237792..3238034) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3237792..3238034) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3238035..3238098) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3238087..3238102) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3238098) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3238114..3238123) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3238131 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3238179..3238469) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3238179..3238469) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3238185) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3238494..3238513) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3238511) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3238519..3240579) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3238519..3240579) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3238527..3238534) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3240608..3240626) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3240612) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3240641..3240647) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3240672..3240677 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3240691 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3240693..3240711 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3240705..3240779 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3240780..3242060 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3240780..3242060 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3242061..3242200 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3242157 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3242218..3242946) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3242218..3242946) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3242235) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3242977..3242996) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3242988) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3243010..3243017) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3243134..3243241) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3243177) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3243242..3244075) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3243242..3244075) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3244106..3244125) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3244125) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3244139..3244146) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3244171..3244851) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3244171..3244851) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3244898..3244917) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3244907) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3244931..3244938) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3244999..3245002 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3245017..3245036 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3245017 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3245058..3246344 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3245058..3246344 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3245789..3245807) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3245797) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3245821..3245828) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3246315 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3246363..3247802) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3246363..3247802) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3246386) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3247826..3247845) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3247843) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3247884..3249032) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3247884..3249032) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3249059..3249075) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3249075) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3249077..3249161) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3249090..3249095) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3249162..3249350) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3249162..3249350) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3249381..3249512) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3249381..3249512) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3249524..3249985) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3249524..3249985) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3250001..3250297) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3250001..3250297) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3250325..3250813) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3250325..3250813) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3250831..3251283) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3250831..3251283) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3251284..3251352) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3251353..3251682) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3251353..3251682) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3251683..3251804) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3251805..3252221) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3251805..3252221) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3252272..3252640) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3252272..3252640) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3252634..3253104) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3252634..3253104) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3253105..3253429) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3253430..3253858) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3253430..3253858) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3253920..3260924) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3253920..3260924) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3260931..3260945 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3260945 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3260955..3260974) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3260970) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3260989..3260996) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3261086..3262021) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3261086..3262021) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3261307) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3262022..3262142) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3262173..3262619) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3262173..3262619) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3262187) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3262656..3262675) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3262663) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3262689..3262696) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3262722..3264131) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3262722..3264131) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3264154..3265983) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3264154..3265983) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3265975..3266075) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3266015) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3266017..3266209) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3266190..3266209) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266209) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3266211..3266344) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3266222..3266229) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3266366..3266674) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3266366..3266674) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3266389) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3266720..3267163) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3266720..3267163) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3267160..3268869) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3267160..3268869) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3268031..3268050) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3268039) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3268889..3269158) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3268889..3269158) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3269170..3269535) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3269170..3269535) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3269536..3269601) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3269588..3269607) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3269601) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3269622..3269625) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3269842..3271251) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3269842..3271251) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3269865) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3271252..3271361) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3271385..3271549) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3271385..3271549) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3271434..3271452) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3271449) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3271463..3271471) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3271741..3271760) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3271757) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3271773..3271780) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3271789..3271796 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3271811..3271830 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3271814 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3271868..3272314 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3271868..3272314 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3272319 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3272427..3273953 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3272427..3273953 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3273950..3275608 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3273950..3275608 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3275621..3276886 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3275621..3276886 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3276879..3277838 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3276879..3277838 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3277839..3277913 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3277914..3279341 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3277914..3279341 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3279337 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3279385..3280686) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3279385..3280686) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3279402) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3280716..3281897) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3280716..3281897) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3281898..3281977) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3281978..3282649) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3281978..3282649) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3282598..3282601 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3282616 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3282617..3282636 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3282677..3282696) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3282692) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3282710..3282717) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3282755..3283696) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3282755..3283696) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3283741..3283760) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283747) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3283749..3283829) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3283776..3283779) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3283845..3283846 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_018" promotor_-35 3283942..3283948 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3283964..3283982 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3283974 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3284036..3285421 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3284036..3285421 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3285407 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3285452..3286002 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3285463..3287343) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3285463..3287343) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3285469) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3287344..3287441) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3287432..3287451) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3287441) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3287466..3287473) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3287511..3287762) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3287511..3287762) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3287529) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3287784..3287803) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3287793) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3287826..3287832 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3287846..3287864 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3287847 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3287879..3288700 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3287879..3288700 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3288684 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3288729..3289871) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3288729..3289871) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3288739) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3289872..3289971) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3289959..3289978) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3289970) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3289992..3289999) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3290014..3291351 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3290014..3291351 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3290756..3291356) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3291390..3291869) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3291390..3291869) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3291401) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3291949..3292941) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3291949..3292941) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3291973) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3292931 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3292964..3292983) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3292982) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3292998..3293005) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3293004..3293011 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3293025..3293449 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3293025 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3293026..3293045 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3293031..3293443 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3293031..3293443 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3293051) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3293061..3293075) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3293083..3293087) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3293415 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3293450..3294184 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3293450..3294184 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3294184..3294453 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3294184..3294453 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3294457..3294939 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3294457..3294939 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3294960..3297203 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3294960..3297203 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3297200..3298399 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3297200..3298399 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3298155..3298173) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3298177) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3298188..3298194) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3298390 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3298463) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3298463..3299695) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3298463..3299695) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3299727..3299746) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3299739) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3299760..3299765) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3299796..3300221) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3299796..3300221) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3300249..3300268) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3300263) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3300281..3300287) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3300413..3300420 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3300430 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3300435..3300454 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3300478..3300933 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3300478..3300933 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3300871 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3300934..3301547 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3300963..3302171) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3300963..3302171) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3300990) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3302172..3302278) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3302279..3303292) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3302279..3303292) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3303293..3303366) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3303351..3303370) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3303366) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3303383..3303390) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3303386..3303961) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3303386..3303961) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3303410) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3303990..3304009) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3304004) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3304024..3304031) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3304032..3304038 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3304053..3304071 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3304060 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3304092..3305162 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3304092..3305162 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3305160 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3305219..3305650) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3305219..3305650) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3305680..3305687 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3305701..3305720 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3305710..3305876 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3305710 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3305762..3305781) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3305782) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3305796..3305803) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3305877..3306281 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3305877..3306281 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3305898..3306950) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3306251..3306943 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3306251..3306943 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3306983..3308014) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3306983..3308014) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3306995) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3307981..3307984 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3307997 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3308001..3308020 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3308051..3308069) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3308069) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3308084..3308090) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3308107..3309255) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3308107..3309255) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3309294..3309313) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3309305) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3309324..3309331) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3309377..3309384 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3309398..3309417 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3309405 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3309451..3310182 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3309451..3310182 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3310175..3311716 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3310175..3311716 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3311745..3313091 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3311745..3313091 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3312544..3312548 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3312564..3312583 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3312573 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3313114..3314520 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3313114..3314520 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3314509 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3314617..3314636 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3314619..3314910 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3314619 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3314883..3314890 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3314905..3314924 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3314912 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3314934..3314941 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3314956..3314975 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3314959) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3314962..3314976) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3314971 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3314984..3314988) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3314984..3315547 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3314984..3315547 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3315561..3317090 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3315561..3317090 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3316917) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3317083 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3317116..3317199) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3317159) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3317200..3318639) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3317200..3318639) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3318653..3318883) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3318653..3318883) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3318884..3319095) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3319092..3319111) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3319097) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3319126..3319133) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3319159..3319166 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3319177..3319196 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3319192 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3319227..3319937 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3319227..3319937 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3319965..3320123 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3319965..3320123 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3320200 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3320254..3320976) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3320254..3320976) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3320266) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3320877..3320880 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3320896..3320900 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3320911 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3320997..3321626) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3320997..3321626) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3321627..3321775) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3321776..3322534) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3321776..3322534) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3322224..3322243) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3322240) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3322256..3322263) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3322515..3323474) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3322515..3323474) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3323463 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3323510..3323513 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3323518 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3323532..3323681) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3323532..3323681) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3323539) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3323590..3323607 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3323595 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3323676 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3323702..3323721) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3323723) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3323736..3323743) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3324016..3324023 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3324038..3324057 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3324042 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3324153..3326078 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3324153..3326078 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3326079..>3326108 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" SCAR 3326108..3326109 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_025" downshifts 3326118 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3326366..3327256) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3326366..3327256) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3326372) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3326434) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3327330..3328733) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3327330..3328733) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3328734..3328955) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3328956..3330161) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3328956..3330161) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3330218..3330236) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3330221) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3330331..3330336 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3330351..3330370 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3330366 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3330402..3331787 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3330402..3331787 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3331769..3331957) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3331769..3331957) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3332074..3332202) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3332074..3332202) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3332126 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3332222..3333424) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3332222..3333424) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3332246) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3333456..3333467) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3333456) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3333482..3333488) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3333506..3334300) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3333506..3334300) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3334322..3335164) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3334322..3335164) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3335151..3336518) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3335151..3336518) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3335745,3335747) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3336508..3338343) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3336508..3338343) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3338351..3339058) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3338351..3339058) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3339059..3339155) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3339143..3339162) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3339155) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3339157..3339349) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3339178..3339181) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3339349) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3339359..3339378) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3339441) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3339442..3339514) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3339442..3339514) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3339550..3339626) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3339550..3339626) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3339627..3339707) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3339708..3339779) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3339708..3339779) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3339789..3339864) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3339789..3339864) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3339836..3339852 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3339849 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3339865..3339961) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3339945..3339964) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3339961) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3339978..3339985) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3339995..3340096) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3340035) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3340089..3341381) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3340089..3341381) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3340100) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3341421..3341440) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3341441) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3341455..3341462) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3341587..3342006) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3341587..3342006) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3342004..3342015) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3342015) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3342030..3342036) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3342127..3343491) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3342127..3343491) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3342147) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3342191) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3343522..3343541) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3343536) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3343556..3343558) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3343603..3343609 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3343624..3343642 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3343626 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3343661..3343861 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3343661..3343861 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3343831 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3343876..3344197 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3343909..3344112) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3343909..3344112) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3344113..3344413) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3344178..3344181 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3344196..3344215 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3344199 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3344233..3344373 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3344233..3344373 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3344374..3344445 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3344421) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3344424..3344438) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3344446..3344450) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3344446..3345654 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3344446..3345654 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3345635 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3345759..3347816 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3345759..3347816 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3347681 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3347853..3348302) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3347853..3348302) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3347867) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3348299..3350278) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3348299..3350278) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3348780..3348799) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3348783) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3349196..3349203 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3349217..3349235 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3349221..3349887 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3349221 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3350315..3351244) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3350315..3351244) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3351245..3351381) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3351363..3351382) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3351381) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3351397..3351402) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3351471..3351620) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3351471..3351620) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3351497) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3351659..3351678) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3351676) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3351692..3351698) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3351699..3351708 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3351721..3351740 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3351727 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3351739) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3351741..3352254) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3351743..3351757) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3351766..3351770) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3351766..3352248 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3351766..3352248 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3352235 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3352278..3352655) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3352278..3352655) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3352280..3352809 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3352299) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3352710..3352729) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3352722) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3352743..3352750) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3352791..3352795 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3352809..3352828 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3352811 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3352836..3352850) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3352839) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3352860..3353789 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3352860..3353789 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3353775 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3353791..3353792 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_014" CDS complement(3353794..3354348) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3353794..3354348) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3354366..3354746) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3354366..3354746) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3354802..3355737) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3354802..3355737) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3355727..3355736 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3355750..3355769 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3355757 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3355781..3355800) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3355795) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3355796..3356554) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3355796..3356554) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3355813..3355820) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3356087..3356590 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3356549 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3356619..3356858) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3356619..3356858) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3356625) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3356693) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3356902..3357420) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3356902..3357420) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3357461..3357748) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3357461..3357748) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3357749..3357815) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3357814..3357833) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3357815) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3357847..3357852) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3357859..3358959) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3357859..3358959) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3359007..3359026) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3359022) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3359041..3359048) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3359086..3361089) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3359086..3361089) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3361140..3361346) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3361140..3361346) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3361308..3361327) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3361333) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3361342..3361348) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3361372..3361391) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3361383) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3361408..3361412) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3361440..3362456) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3361440..3362456) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3362489..3362507) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3362501) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3362523..3362528) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3362632) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3362816..3362821 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3362834..3362915 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3362834 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3362837..3362855 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3362916..3363533 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3362916..3363533 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3363504..3363512 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3363523 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3363526..3363544 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3363545 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3363572..3364420) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3363572..3364420) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3363592) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3364413..3365174) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3364413..3365174) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3365208..3365227) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3365226) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3365318) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3365321..3365329) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3365343..3365351) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3365355..3365363 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3365371 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3365375..3365393 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3365422..3365862 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3365422..3365862 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3365811 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3365913..3366764) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3365913..3366764) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3365932) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3366765..3366885) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3366886..3367605) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3366886..3367605) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3367619..3369505) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3367619..3369505) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3369526..3370905) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3369526..3370905) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3370906..3371036) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3371028..3371047) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3371036) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3371063..3371067) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3371091..3371110) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3371101) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3371124..3371131) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3371191..3371197 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3371202..3373487 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3371202 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3371212..3371231 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3371216..3371842) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3371216..3371842) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3371233) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3371839..3372624) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3371839..3372624) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3372669..3372688) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3372681) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3372683..3372768) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3372700..3372706) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3372769..3373119) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3372769..3373119) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3373120..3373270) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3373271..3373405) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3373271..3373405) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3373429..3373529 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3373441..3373460) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3373451) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3373453..3373521) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3373476..3373483) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3373489..>3373622 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3373489 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3373507..3373526) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3373521) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3373542..3373546) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3373623..3373770 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3373646..3373919) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3373772..3374031 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcagatacaa gattcaatgc agtttgccgc ggttgaaagt ggtctgcgct 226681 tttaccaggc atatgatcaa agcctttctt tgtggccgat tgagtcggaa gcattctatg 226741 tttctactcg ttttggaaaa acacatatca ttgcaagtgg gccaaaggac gcaccttcgc 226801 tcattttgct tcacggaggc cttttcagct ctgcgatgtg gtatccgaat atcgcagcgt 226861 ggagcagtca atttcgtaca tatgcggtcg atataatagg agacaaaaat aaaagtatac 226921 catcagcagc catggaaacg agagctgatt ttgcagaatg gatgaaagat gtctttgatt 226981 ctcttggact tgagacggca catctggccg gcctttcgct tggcgggtcc catatcgtga 227041 atttcttact ccgcgcgcct gaaagagtag agcgggcggt tgttatcagt cccgctgaag 227101 cgtttatttc atttcatccg gatgtctata aatacgctgc agagcttaca ggggcaagag 227161 gagctgaatc atatatcaag tggatcacag gcgacagtta tgatctgcat cctttactgc 227221 aaagacaaat tgtggcgggc gtggaatggc aggatgagca aaggagcctg aagccgacag 227281 aaaacggctt tccgtacgtg ttcacagacc aggaattgaa atcaatacaa gtcccggtac 227341 ttctgatgtt cggtgagcac gaggctatgt accatcagca aatggccttt gagcgggctt 227401 cggtattggt gccgggaatt caggctgaaa tcgtaaagaa cgccggacat ctgttatctc 227461 tggagcagcc agagtacgtc aatcaacgcg tcttgtcctt tttatgcggg gggataaaat 227521 agtaaggaac atgaaaagat tggcattcat ttttcaaaag gtaacaaatg ttgtataata 227581 atagaatttg aatgctgctt tttttgggag cattctatgt tatcatgctt attggagaaa 227641 aatttttcct gtaacgctat tcgatcacta tcgtcaaata atatagatgg ttttacaatt 227701 ggaggtttgg ttacactgtg aattacatcc cctgtatgat tacgatagga aacttcattt 227761 gcggattgct ggcgattcat tccttgctat atcacaacat tcattcagca gtgcttttta 227821 tttttacagg catgttcctt gatttctttg acgggatggc tgctcgtaag ctgaatgccg 227881 tttctgatat ggggagagaa ctggattcgt ttgccgatct ggttacgttt ggggtggctc 227941 cttctatgct tgcttacagt gtcgcgttgt ataccctgcc atttatcggg atcttatgcg 228001 cattgacgta cagcatttgc ggaatgcttc gcctctctaa atttaacatt gaacaaagca 228061 agctcccgac gtttatcggt atgccgattc cgtttgcggg catgtgtctc gttattctaa 228121 gcttcaccta taacccgatc cttctggcaa tcggcacttg cggactctca tatttgatgg 228181 tgagtaaaat aaaattccct cattttaaaa aacatgcggc agaaaacctg gagtctggga 228241 gatggaatta gttcagcagc tcatagcgga ttacggttat ctcgctattt ttttgatgct 228301 ggtattagga attgtaggat tgccgattcc agatgaagtg atgatgaccg ttgttggcta 228361 tttcacgcat accgatgtat tgaattatga gctttcgata ttgattagtt ttgtcggggc 228421 tttgttaggt atgctgatca gctacatgat tggcagaaaa gccggacgcc cgtttatcga 228481 caagtacggc aagtgggtcg gcttaaaaga aaaaagaatg atgaaagtgg aaaaatggat 228541 gaagaaatac ggtccatatt ctcttatttt aggttatttt attcccggcg tcagacatgt 228601 gacgtgctac ttttcgggga tcggcaaaat ggatctgaaa acgtatgttg cgtttgctgc 228661 aatcggcgcc tttttatggt gctttgtttt tattacaatc ggaagggtta tagggattat 228721 tcatgtttaa tacggctgta aagattctgt atcgatcatt gatagagctg acgaatcatc 228781 gtctgtcatc ctatctgatt aaaggatttt gcgagtcgaa aatcagcaaa ccggtcattc 228841 cgcttttctc aaaacatttt cggctgaatt gggatgatgt ggacggtacg gctgctgatt 228901 acggatcgct gtccgaattg ttcattcgac aaataaatct ggagcggcgc cctgtgtcaa 228961 aagaggcgca tgcggtggtc agccctgttg acggtgtggt tcagacggta ggaatcatca 229021 acccgaatca aacctttacg gtgaagggaa aagattactc attcgctgag ctgaccggct 229081 gtaaaagcgc agaccatcaa tacaacggcg gatatttcgt cgtgctgtat ttaagcccga 229141 ggcattatca ccgtttccat tctccgatca gctgcaggta tcaaaagctg gccgagctcg 229201 gaaatcgctc atacccggta aatcaactag gcttaaaata cgggaaagat gtgctgtcga 229261 aaaattatcg gtttgtgtac gagctgaata gcggcagccg aaatgtcctg atgattcctg 229321 tcggcgcgat gaatattaat tctatcgtgc agacgaatac ccgtactgaa ttggagatcg 229381 gcgaggagct gggatacttt tcatttggct caaccgtcat tttggttttt gaaaaagacg 229441 cgttccagcc gtccgcccat ttagcagaag gccaagaagt ccaagtcgga gaactgatag 229501 gttacgaaga ataaaaagag gagcttgcat aaacgcagcg cctctttttt tgaagaaagg 229561 tgagattcat ggagaaacaa atcatcagct ggattacaga ttatcagaac accggagatg 229621 aagccgtcct gcggcaagtg cgagaagtgt gctggccgat cgttgaagcg gttttgcaag 229681 agaaagtaat ggatgatgaa caagcgaaca atttgcgcga aaaaggaatc gagcggtttc 229741 cattcatcat cagcaaatac caagcggatg tgcagcttcc ggttgagaca tttttacaaa 229801 atacgtatcg gttttacttt catcaggtga tgagagaatc cagctaaagc ttctttcaac 229861 agagaagctt ttttttgttg gcaggaaaag gaaacttttt ctatatctat ctcgtaatga 229921 ctagagaacc tagcagaaaa ggagagatag aattgaaacg aatgatagtg agaatgaccc 229981 tgccgctgct gatcgtttgt ctggcgtttt cttctttttc agcctcagcc cgtgctgctt 230041 ctgaagaaaa atattgggat cactggattg aacgacatgc acagcctctg gatgcttcca 230101 atgcttcaaa caaagacctt cgatttctaa aaaaggtgct gaagggaaaa cgaatcgttc 230161 agttaggaga aaccacacac ggtgctggcg aaatcaatgc cacaaaggtc agaatgatca 230221 aatacctcca cgaagagctg ggatacgatg tattggcctt tgaatccggc tttcctgata 230281 caaatgcatc ctaccttaat atggaccaat taacccctaa aagcacgatg aaaaactcca 230341 tttacgctgt atggcacaca gaagatgtcg tcgaattgtt tgattacatg aaagagcaaa 230401 aagagaaagg cgatccgctg atccttaccg gttttgatat tcaaagcatg aagaattcat 230461 tcaatgtagc tgcgactcaa tgggtaaaag cggtggaccc tgagaaagca gagttgctct 230521 cccaatcaga aaatgatttt tcaacattag tgacagacag caatacgttt gatgaatttt 230581 cgcaaaagaa ggaaaagctt gtgaaaaact atcagaagct gatcaagttc actaaaacac 230641 atgcttcaga gctaaaagaa aaccttccaa aagagccgaa agcttatgag atgtttatgc 230701 attctcttca gctgagaatt gacgtaatgg aaacatatat gctggaagaa atgaaagaaa 230761 aactagagga gtatccggag aatattgagg atttttcatt ctttatgaga gaccgcatga 230821 tggctgaaca atttcagtgg gtagccgaca ccctttatcc gaaaaagaaa atcattgtct 230881 ggggccacaa ttaccatcta cgcaaacaga atacgaagat gataaaggac tgggtacagc 230941 taaacggccc taacatgggt gattatttgc cggagcggct gaaaaaacaa acatatacga 231001 ttggcattta tgcttactca ggtgcgagtc ttgatagctc cgataataag actgttaagc 231061 cggttacaag cccgccgccg tctgggagcc ttgaagcttt gctgaaagcg gcggaccgac 231121 cggctgtttt tgttgatttt ctccatacaa aaaacaagaa aggcacttcg tggatgtata 231181 ccccgcggac tgcgctctat tgggggtaca tggaagagca gatgatcctg aaggaacaat 231241 atgacggtgt catttggctg gagcatatca cgccctctgt cattatcaag tgagcggtgt 231301 cccctgtggt aaacagggga tttttacata tcgcaaaaat aatcaaaaca tataatccgt 231361 gatccattat tctaaaacag aaaggagatt ggagcgtgca atgtattatg aaaaagctgt 231421 ccagaaaaca atcaattgga ttgaatcaca tttacatgag caaatatcaa acgaggatat 231481 tgttaacgtt tcaagctttt caaaattcca ttttcatcgg atttttcaaa aagaagtcgg 231541 catgtcggtt gcttcttata ttcggttaag acgtcttgcg aatgcggcgg cagctttgct 231601 ttatacagat catcgtatta tcgatattgc tttgtattat cagtttgaat ctcaagaagc 231661 atttacgagg acgttcaaaa agatgtatca catgccgcca ggagcatacc gaacatttat 231721 gaaacgcttt acttcaaaaa aggaggaatc ttacatggag aaaaaaatga aaggctgggt 231781 attgagcggg agccatccgt tccaattcga aatggggatt gaccgggaaa atgtacatca 231841 gggaaaagct tcagggtatt taaagtcaac gatggttcag gatatcggtg aatttgcgac 231901 gatgatgcag caattcaaag cagatcgcta tctaggaaaa aggcttcgtc tatcaagttt 231961 tatcaaaaca aagggggtgc agcattttgc ctcactttgg atgcgggttg acagtgctgc 232021 tgatgatgtt ctccaatttg ataatatgag caacagacct attaccggaa caaccaattg 232081 gaatcattat gctatcgttt tagatgtccc agaaaatagc gctgtgatat cttttggcgt 232141 tcaattatct gggccgggtc aggtgtggat ggatcatgtt gtttttgaag aggtagatga 232201 gagcgttcct tcaacaaacc ttgaaatgcc gggagaactt ttagatgaac cggtaaattt 232261 atcttttgaa gaggaactac aaaaatagtt ttcagacaac tacttttatt agtgagttaa 232321 tggaaaatac tatttgttat taataaaccc ttgtgctgct taggtttgta agagcttgga 232381 tatttttatc agtctgggcg gatctgttca tctttgcggc attttcctgt atgatatagt 232441 aagagtgtgc atagcaacta actataattg aacagggtgt ttaaaacatg gaaaaacaat 232501 acagagtatt actttactat aaatatgttc cgattgaaga tccagaggcg tttagagagc 232561 agcatctggc tttttgtaag gagcttggtt tgttaggccg tatccttgtt tcttctgaag 232621 gaattaacgg tacggtatca ggtacggttg aacagactga aaaatatatg gaaacaatga 232681 aagctgatcc tcgctttgcg gacatggtat ttaaaattga tgaagcagaa ggccatgcct 232741 tcaaaaaaat cttcgtccgc cataaaaaag agcttgtaac gcttcgtctt gaagatgatg 232801 tcgatccgaa cgaaacaaca ggccagcatt tgaagcctgc agaattttat gagaagatgc 232861 aggatccaaa cacaattgtc atcgacgcgc gtaacgatta cgagtatgac cttggccatt 232921 tcagaggtgc ggtccgtcct gacatcgaag ccttccgtga attacctgaa tggattgaag 232981 agcacaaaga tatgcttgaa ggcaaaaaga ttttaacgta ctgtacaggc ggcgtgcgct 233041 gtgaaaagtt ctcaggatgg ctggtgaagc aaggctttga agatgtagct cagcttgatg 233101 gcggaatcgt gacatacgga aaagatccag aggtgcaagg caagctttgg gacggccagt 233161 gctacgtatt tgatgaaaga atcagcgtgc ctgtcaaccg tgtcgagcat gtgattgtcg 233221 gcaaggacta ctttacagga gaaccgtgtg agcgttatgt gaactgcgca aatccatctt 233281 gcaataaaaa aatgatatgc acaccggaaa atgagtataa atatatgcgc agctgcagcc 233341 acgaatgccg cacgaaccca agaaacctgt atgtgaaaga gcataatatg acagaagaag 233401 aagtaaacgc aagactggca gcgattgaaa cagaagatca cgctgctgct gaataaaaaa 233461 agaacacctc gtattgaggt gttctttttt tctatatgct ttcagtttgg ctgtttgcgg 233521 aaacccattc tttttggcgg aaggcctttt cccattttga taccacgata caggcgatcg 233581 catgtcccgg tacgttcacg cctgttctcg ccatgtccat gacgcggtca acacccgcga 233641 taatggcaac gccttcagcc ggcagtccta cagcattggc agtcgccaga agaactacaa 233701 gcgatcctga gggtacagct gcaatgcctt tactggtcat cacaagcaca agcatcatga 233761 gcagctgctg ggacaatgtc atgtctactt gaaaggcctg tgcgagaaag atacaagaaa 233821 ccgataaata taagctggag ccgtcacagt tcaatgacaa gccggaggga acgacaaatg 233881 ataccactcg tttgggacag ccgtatttct ccattctatc catcagctga gggagaatgg 233941 tttcagtgct tgtggtggaa aatgcaatta aaaacagatc ccatatcatt ttcaatactt 234001 cgaaatactt aatctgaaag atgagaccga caagcggaaa gaggacaaag aggatcagga 234061 acaggccaag gaatacggtg ccaaccagct taaacatagg gaggaggagt tcaatgccat 234121 attggcctac agaagcagcc atcagggcta acacgccgat aggagcagtg accatgacga 234181 tttgcgtgag cttgaacata atctgagctg tagattcaaa aaacttcatt actggttcag 234241 aagctttgcc gataccagct gcggcgacac caaataaaat ggcgaagaaa ataacggcaa 234301 gcaaatcatt tctggccatg acatcaataa tgtttgtagg gataatatcc aggatcattt 234361 gcttgaaatc aacaactttg tctgtgtagc cggaaagttc atgaatatct ttttttgcca 234421 aatgggagag gtcaagcccg acacctggtt ttaagacatt cgctaataaa agtccaagcc 234481 ctaataccaa cgttgtaatc acttcgaacc aaatgatcgt cttgatgccg agactgccca 234541 tttttttcat gcttccgctt cctgcggctc caatgacaat ggtagaaaat acaatcggca 234601 caacaatcat tttaatcagg cggataaatc catctccgac aggcctcagt gccatcccga 234661 aatcaggaaa aaagtggccg atcaccgcgc cgacagccaa agcgattaaa atttgaaacg 234721 cgattaattt tttcaaatga atcccccttt agaacgatag aatgtaggca tattcatatc 234781 attcgtgatt caaatgcaaa cacctttttt caagttattt tattttgaca gcgctttcat 234841 tatgttggcg aaaaagtccc ccgcagcagg ggggactttt ttacttcatt tgaatgtgct 234901 ttagatcttc ttcagaggta tttgtgaaaa taaccggtgt tatggctgaa gcggcatgct 234961 gcttgatgta attgagatca aaggtgagaa gcagttcgcc ttgtttgacg gcttgtccgc 235021 ttgtgacatg tgcttcaaag ccttccccat tcagtttgac ggtatcgatg ccgacatgaa 235081 tcaggatttc agtgccgccg gcgctcataa agccgatggc gtgttttgtc ggaaaaatcg 235141 agacgatctc gccgtccgca ggtgcaacga cttttccttc tgatggtata atcgcaaatc 235201 cctcgcccat cattttttct gaaaagacct gatcaggcac atcccctaaa gagactgttt 235261 ctcctttaat cggataaata aaggtctcat cggaatcggg cttcagcggt ttgtcagtta 235321 ccgtgtccag cgcggcggcg gtggcaggga cgcctccggc catgattgtt ttgatgtcgt 235381 cttttaaggc atcggacttg gttccgaata ttgcctggaa gttgttgttg acctccagca 235441 cacctactgc accaagccgt tttaattcat ccttgcagac ttggcttggc tgatgaacgg 235501 tcacacgaag ccttgtgata catgcatcca ggttagcgat attttgctgt ccgcccaagg 235561 cctgcagcac gtgaaaggca agctggtctt ttgcaactgg agctttctcc tcattctgac 235621 cgtcttcatc tgtctcacgg ccgggcgttt tcaaattcca tttcagaatc gcaaatcgga 235681 acaaataata ataaatgaaa gcaaacacga tcccgacagg aatgacaacc cagccgtttg 235741 tagacagtcc gtagttcaag acgtagtcaa ttcctccgcc tgagaacgta tagccgtggc 235801 ggacatggaa taaatcacaa acgacaaaga tgacgccggc aagaatagag ttaatcaaat 235861 agagcacggg cgcaacgaac aagaaagaaa actcaaccgg ttctgtaatt ccggtcagca 235921 tagatgtgag cgccgcagaa atcatcacgc cggagatcat ttttttcttt tccggacgcg 235981 cggtatggat aatggcaaga gcaacggccg gcagacagaa aatcatgtaa gggaaatccc 236041 ccatcataaa gcgcccggct gtcgggtctc ccgcgaaaaa ccttgtcagg tcgccggtta 236101 cggtgttgcc tgttgatggg tctgtgtatt ctcccatcat aaaatagaaa ggcgtataaa 236161 aaatatgatg caggccaaaa ggaatcagca aacgatagat cgttgcataa aagaacaggc 236221 cgactgttga atcggcaatt aaactgctgg ctgcgttaat tccgttttgg atcagcggcc 236281 aaacgaatga gaaaatgacg ccgatcacca atgaactgac ggaagtaatg atcgggacaa 236341 agcgttttcc agagaaaaat ccaaggaccg gatgcagctc gattgatgaa aatcgcttat 236401 ataaataggc ggcgagaagc ccgataatga ttcctccgaa aacccccata tcaatcaggt 236461 gctcggctcc ttcatacgga ggctgaaggc cgagtaattt tcccatattg tcgagggtga 236521 cggttaaaat taagtatccg atgacagcgg caagtccggc tacaccttct ccgccggcta 236581 atccgatcgc gacccccacg gcgaaaatca gcggaaggtt atcgaataca acgccgcccg 236641 catcctttat aatagggatg ttcagtaaat ccttgtctcc gaaacggagc aaaagacctg 236701 ctgccggcag gacggcaacc ggagtcatca acgcgcggcc aagctgctgc agaatttgaa 236761 atgccttttt aaacatgaca gtctcctttt attgtgttat gagaatgatg cactctttaa 236821 tttttgagct gctttataat cggcgataac ggttacatga ttgtgttttt gaagaatgga 236881 ggctggtaca tctgtcgtga caggaccttc agccatcttt tgaatggcgt ctgctttttc 236941 ctcgccgctt gctaaaagca caatatgttt gctgaattcc atgatggttt taatgcccat 237001 tgaaatcgcg agtctcggaa ccagcaccgg atcgccgccg aagaatctgg catttgcctg 237061 tatcgtgctt tccgagagct tcacaacacg tgtccggtct tcaaaatcag atcccggttc 237121 attaaaaccg atatggccat tggcgccgat gccgagaatt tggacatcaa tgcctcccgc 237181 ctggcggatg agatcctcgt atactttgca tgccgcctca agctgcggat tgtctccttg 237241 cgggatatga atatgatcag gctgcatatt gatatgctga aaaagatgct catgcataaa 237301 atggttataa ctttgcggat gagatggaga gagaccagca tattcatcca aattaaatgt 237361 agtaaccttt gaaaaatcaa tttcgcctgc ctgatagtct gaaatcaact gcttatacaa 237421 gccgaccggt gtgcttcctg ttgccaggcc gagaacggca tctttcttag cttgtatttg 237481 ttctttaata atggcagcgc ttaacttaca gagttcttcg tagtgctcgg cgatcagaat 237541 cttcatgtga caccccctca aagagataga caagcaccat atttgttatg accaatttat 237601 gatacttgtc attacgaatt tagcaccgcc cttatcaaac tgtcaatatt aatttctgaa 237661 aatttgttat aaaagaagga tacaaatctt tcatattggg agggcaaatg gtattatggt 237721 ctcaatgaaa aagaacggat tgcatacaga atggggagaa tgaaatgaca gctttatatt 237781 ctgttatcaa gtttaaaatc attgagttaa ttaaatcggg caaatatcag gcgaatgatc 237841 agctgccgac ggagagtgag ttttgcgaac aatatgatgt cagcagaaca actgtgagac 237901 tggctctgca gcagctagag cttgagggat atattaaaag aattcaagga aaagggacat 237961 ttgtatcggc ggccaaaata caaacgccga ttccgcataa gattacgagc tttgcagaac 238021 aaatgagagg acttcgttct gaatcaaaag tgcttgagct tgtggtgatt cctgccgatc 238081 attccatcgc cgagcttttg aaaatgaaag agaatgaacc tgtcaacaag cttgtcagag 238141 tcagatacgc cgagggggaa cctttgcagt atcatacctc atatattccc tggaaggcgg 238201 caccggggct ggcgcaggag gaatgcaccg gctcgctgtt tgaattgtta aggacaaaat 238261 acaatattga aatcagcagg ggcacggaat cgatcgaacc gattttaacg gatgaaacga 238321 tcagcggaca cttattaacc aatgtcggag cgcctgcgtt tttatcagaa tcccttacct 238381 atgataaaaa tgaagaagtg gtggaatatg cgcaaattat tacacgggga gaccgaacga 238441 aattcaccgt agaacagtca tatcattcat aaagcaatgt gttttaagaa gggaatggtg 238501 gttctatgtt tttatttacg aatggaaaag tgctgtgggg agcagtgatt gctgcattca 238561 tcctttcaat tgtattttac ccttttctgc cgacgcagat gccgattcat tatgatgttg 238621 cgaacagtcc ggatctgacg gttaacaagc tggcggggac tgtgatgctg cctgttttga 238681 tggtggtgtt tgcatgggcg cggaagatca attggcaatt tgtattcgca gtgtatattt 238741 tgctgatttg ccacattgtc gtcctttgtt tagcgctcta aatcaaacag ccagaataaa 238801 actggctgtt ttctttaatt tcagcttcat ctgacaatga atgtggtgta taatagctga 238861 tgatcctaaa gaatattctg aaatttatag gtgtgaagcg gcgtattatt aaaggaaagg 238921 ctgtatactt tttgcagctt taaaaagact gaatatttaa acaattatgt gaaaggtgtg 238981 ctgattagat tgaataagct tattgaacga gaaaaaactg tatattataa ggaaaagccc 239041 gacccgtctt ccttggggtt tggacaatat tttacagatt atatgtttgt gatggactac 239101 gaagagggga ttggatggca tcatccgaga attgcgccgt acgcaccgct tacgcttgat 239161 ccgtcttcat ctgtttttca ttacggccag gctgtttttg aaggattaaa agcatacaga 239221 acagacgacg gcagggtgct gctgttccgt ccggatcaaa atatcaaacg gctgaacaga 239281 tcgtgtgagc gcatgagcat gcccccttta gacgaagagc tggtgcttga ggcattgacg 239341 caattagttg agctggagaa agattgggtt ccaaaggaaa aaggaacgtc actgtatatt 239401 cgtccttttg tcattgccac agaaccgagt ctcggtgtga aggcatccag gagctataca 239461 tttatgatcg tgctttcgcc tgtcggctcc tattatggcg acgatcagct gaagccggtt 239521 agaatctatg tcgaagatga gtatgtgagg gcggtcaacg gaggagtcgg gtttgcaaaa 239581 acggctggaa actatgccgc cagtcttcag gcacagcgga aagcgaatga actgggctat 239641 gaccaggtac tgtggctgga cgccatcgaa aagaaatatg tggaagaagt agggagcatg 239701 aacatctttt tcgtcataaa cggggaagct gtcacacctg ctttaagcgg aagcatttta 239761 agcggggtta cacgtgcgtc tgcgattgaa ttgattcgaa gctggggcat tccggttcgt 239821 gaagagagaa tatcgattga tgaggtgtat gcggcctctg cacgcggaga attgacagag 239881 gtctttggca caggcacggc agcagtcgtt acgcctgtcg gtgaactcaa catccatgga 239941 aaaacggtga ttgtaggcga cgggcaaatc ggggacctct cgaaaaagct gtatgaaacg 240001 ataacagata ttcagcttgg caaggtaaaa ggcccgttta actggacagt ggaagtgtga 240061 aaatcgaaaa agaacctgcc cggaggcagg ttctttttat tttgaatgag tcatatcagc 240121 agccggctgg cttttgcggt tttttacata atatattgca tagcaaatgg ccataaatgg 240181 aacgccgcaa tagagtgcga ttctttgatt cggatcaaag gcaatgccaa cgacggaagc 240241 caggcataac aggaacgcag caatcggcac gaacggatac aaaggggttc tgtatttcaa 240301 atcagtaacc ttgtttcccg cttcgatata acgttttctg aacatgaatt gagaagcagc 240361 gattcccatc cacacgacaa cgacggcaaa accggaaatc gacacgagca caacgtatac 240421 agtgtctggc gcaaatacgc tggacagcaa cgacagaatg ccgccgatca tgctgaacac 240481 cagcgcgtta aaaggggttc cttttgacgt cagctttgca aatgtcggat gaagcgtttt 240541 ttcttttgat aaagaccaca gcatccggga agaagcgtag agtccggaat tagccgctga 240601 caggatcgct gtcaggataa caaagttcat gatatcggct gcgtatggta caccgactct 240661 gtcaaagaca gcgacaaacg ggcttttgat gacacctgca tcttgaatcg gaatcagccc 240721 tgacagcaca aaaattgttc cgacaaagaa gagcgagaga cgccagaccg ttgtttttat 240781 cgcttttggt atcgtcttgt caggatcaac gctttcaccg gctgcgattc cgattagttc 240841 cgttcccgaa aaggcaaaat tgacggacag catcgtcatc aaaatcggga caaatccatt 240901 gggaaaaagc ccgccttccg ccgtgaagtt ggacagcatc ggagcggctt ctccgccttt 240961 gatcgggatg atgccgaaca tggcagagcc gcctaaaaga ataaataata caatggctaa 241021 tactttgatg ctggaaaacc aaaattctga ttcagcgaaa aacttgaccg aaaatgcgtt 241081 aagcaagaag atgaacagcg caaagacggc actccacatc caaaccgatg tatgggggaa 241141 ccagcgctgc attaacaggc cggctgctgt gaattctgat cccaatgcca cggtccatgt 241201 cagccaatac agccaagcga ccgtaaatcc ggtgcccggc cctatgtatt tggctgcata 241261 ggtgtgaaag gcgccggtca caggcatggc gactgacagc tcaccgaggc atagcatgac 241321 cagatagacg atgccggccc cgactaagta ggcgagtatc gttccggccg ggcctgcttg 241381 ctgaatggta taacctgagc ttaaaaacag cccggttccg atgacacctc ccaaggaaag 241441 cataaagagg tgccggcttt tcatacttct ctgaaaggtt gtctcattct tgttgtgggc 241501 agagttcatc tttttccaac tttctatcag cgatttattt ccttcctaat aaaaaatctc 241561 atgtcagaaa gtgacacgag actccggcga accggcttta agttagaata tacaaactat 241621 tccgataagt caagttgttt ttaaagagcg ggcccaagcc gcaatttctt gaatattttc 241681 gggttttgtc cggcagcagc cgccaatcag cctcgctcct ttttcatgcc aggtgcgggc 241741 gctcgccccg taagattctg cgcatgctgc gccgttccac gtttttgttt ccggatcata 241801 ttgctcacct gaattcgggt agacaatgat cggttttgac gtgttctttt ttaactcctc 241861 tatcaaggaa gggatatgct gaagcggcgt gcagttgatg ccgagtgctg caatttggcg 241921 gtgttcatca agccacgatg cgcagtcagc tgcaggtgtt ccgtcactga tatgcaagcc 241981 gtctttagca ctgaagctga tccatgcata cgtttcagga aattccttca acagccgaac 242041 aatcgctttg gcttcagtca gacacggaat cgtttcgcat gccaatacat cagctccggc 242101 ttcaatcagc gccttcatcc gggggcgatg aaattcaatc agttcatctt ctgatattgc 242161 gtagttgccg cgatactcag acccgtctgc aagataagcg ccataagggc ctatagaagc 242221 cgcaatgatc ggttttggcc gattcaaacg gttctcttca agcgaccaaa attcatcacg 242281 tgcttcagct gcgatgctga cggacaactc gatgagccgg cgtgcttccg cttcgctcag 242341 cccgcgtgcg gcaaagcctt caaatgtaga ctgatagctg gcggtgattg cacaatcggc 242401 gcctgccgca aaataatcag tatgaacttg tttaatcagc tccggctctt ccatcaggat 242461 ttttgccgac cacagactgt cattcaaatt acagcccttg cgttcaagct cggtcgccat 242521 ggcgccgtct agcacaataa gcgggtatgt atctaatatg tgttggatag gattcataga 242581 atgtaccgat gccttctttc agattttttt gaaaaagata tgaaaatcgt aatggaggct 242641 tacgtgtttg tcaataaacg caaaaagaga aaggtgttca gcccatatgt ctgaacaccc 242701 ttttcttatg atatttgttt gttgtgcgtg tcagtctttg tgtctgaaac cggccagcac 242761 tcaatgccat tatggttttt gagcacatct ttataaaaga ccggatcctt gcctgctttt 242821 ttctggcgtg tatagtcttt cagcgccgta aaaacgacct ttgatagtaa gaaaatcgcg 242881 attaaattca cgatgaccat caaacccatg aacaaatcag caagatccca gacgagctgg 242941 actttggcaa cacagccaaa cacgatcatt gccagcacgc cgatacggta gacaaaaatc 243001 agttttttgc ttttgttcaa aaagccgata ttggtttcgc cataataata gtttccaatt 243061 agagcacaga atccgaataa caaaatcaga atcgcgagaa agcctgatgc ccatgatccg 243121 acatgggagc tgagggaggc ttgtgtcaag gcgattccgc tcagacccgg agtatgatag 243181 gcatccgaaa acagaatgat aaaagcggtg cttgtacaaa tgaccagtgt atctgtcagt 243241 acaccaaaag cttggatcag cccctgtttg acgggatggc ttgttgtggc ggtggcagcg 243301 gcatttggtg cgcttcccat tcccgcttcg tttgaaaaga ttccccgtct gacgccttgc 243361 atgagtgccg cgcccaaagc cccgccggcg gcctggtcaa aaccaaacgc atttttcacg 243421 attagcgcaa gcacacctgg cagctgcgta atgttggaga aaatgacgaa aaacgcaact 243481 ccgatataca ggacagccaa tacgacgaca atggattcag ccagctttgc aatgcgcttg 243541 actccgccaa aaataatcgt gccgaataca gcaattaaaa tgagtcccaa tgtcaggcgg 243601 tttgtgccaa acgcgttttc aaaggcaagg ctgactgtat tggattgaac cgagttgaag 243661 acgataccga acgataaggt gattaacaca gcgaacagcg cgcccatcca ccttttgttc 243721 agcccttttt ccatgtaata cgccggcccg ccgcggaagc cgtttacatc ttttacttta 243781 taaatctgag ccagtgtgct ttccacaaag ctggatgctg atccgataat ggcgataatc 243841 cacatccaga agattgcacc gggcccgccg agtgcaatgg cgatagcaat gcccgtaata 243901 tttcccgttc cgacacgggc cgccatgctg atgcaaaagg cttgaaacgg agaaatgctg 243961 ttttttgacc gggaagcagc accttctctt aataccctga ccatttcttt cagcatgcga 244021 acctgtaaaa acttaagcct gaacgtaaaa tagattccaa aagaaaggag caaaacaatt 244081 aatagctttg accacaaaag atcatttgca ataccgacga tatgttctag gatttgctgc 244141 atagaatcac ctcttttttc atgtttaaaa aatgctgagc tcccattcct gcgccatatg 244201 cttcagcagc ataccgccag tgaggctgtt gccgtattca tcaatggcag gcccgtaaat 244261 gccgatgccg catccggatt gaaaaggctg ttctcttctg gcgcttggag gcaccagcgc 244321 catgatgccg ccggagacgc cgcttttggc cggcacgccg acaaacgccg catatttgcc 244381 tgaagcgttg tacatgccgc acgtcagcat taatgccttg gccaattttg ccacatcttt 244441 tggaatcacc tgctcgtgtc gaatcggatg atacccgtca tgagcaagga tcaggccgat 244501 caacgcaata tcttctgtag tgctctccat agcgcattgc ttcaagtaca cctcaagtgt 244561 ttcttctact tcagcttcta aaaagtttgt ttcttttaaa tagtaggcca gcgctctgtt 244621 gcggtgggcg gtttcccatt cagaacggaa tacttcttca tgaattcttg gccgttttcc 244681 tatcaaagtt tccatcaccg agtaaagaaa ctcgagcttt tcgtatgcag attctccggg 244741 aaggatcgaa gcgatggtga gggcacccgc gttgatcatg ggattgaagg gctttcccgg 244801 cttgttgatt tcgagccgaa tgattgaatt aaaggcgtca cctgtcggct cgacatctac 244861 gcggtcaagc acatagggaa tgccgcggct catgcaggcg gcaataaagc taatcacttt 244921 tgaaatgctt tgcatggtaa aagagacgtt ccagtcgccg gcgtgtatca tcgttccatc 244981 aggctccaat acacagatgc cgagctgtga atcattgact tttcctaaag cggggatata 245041 gtttgcgctt tgtccattgg cggcaaaagg gcgatagtat tcaacccaat catgaagctg 245101 taacgccggg tttatgtctt tctggtgctc ttttatcaat tctttcatcg aattcctcct 245161 cactgatttt tttcttaaag gactgaggtg tatcaaaacg aaggctaagg gggcgttaaa 245221 cgctttcata atagcggaag gtataattac tgtataatgg agactacaga atcatacaaa 245281 atacgacaaa aacattttga aaataagcag taagatttat aaaaacctca tgttctgggt 245341 caaaagcaat ttgcaggttt tctcccgatt ccccaaaata aaaagcgagg atgtgatcaa 245401 cataaaactg gaacggttta ttgaaaaaga cggatatata ctggccctca tgctgattac 245461 ggtgccgctg gccggtgaac tgaaatttta tcccctcaat gaagaattcc gggtcagctt 245521 tggggcaccg gtttttttct tctttttatc attgttgcgg catgtgcccg ctgtgctgcc 245581 gggttttctg actggagcgg ctgttttcat ctttcgcgtc tttctggaat tatggggcgg 245641 aggacacaat gggctgactc cgattctgta tgatcaagcg tctggctttt tcttttatat 245701 gacttacgcc tgtctgtttt ccatattaaa ggccaatcgt ttccgtgaac ggccgattat 245761 gctcggtttc attgggttta tgattgaagt tgtgtcagat tgtgtcgagc taactgtgca 245821 atttctcatt tttcatacgg ttgtcacgcc tgagaaaatc actgacattg cggtgattgc 245881 gatttctcac acatttattg tgatgagctt ttatagtgtg ctgaagctgt atgaaacaca 245941 atcgagagaa aaacagacaa ggcagcagca cgagcacatg ctgatgatcg tttccaattt 246001 atatgaagaa acggtgcacc taaaaaagac attgaaaacg acagagaaag tgacaaacga 246061 ttcgtatcag ctctatcggg aaatgaaggg caaggatgtt cagctgagcg gcagaatcct 246121 gagactggcc ggagagattc atgaagtgaa aaaggacaac cagcggatat tcgcagggct 246181 ttcaaaactg atttcgaatg agagtttgag agattatatg agggcttctg atttgctgca 246241 gctcgtgatt cgaatgaatg aaaagtacgc tgaagcacta gggaagcaga ttgattttta 246301 ctgctcgatc gagggagagc atgacgaata tcacgtattt atcgtgcttt cgatcattaa 246361 taatctaaca gcaaatgcgg tagaggctat ggatgaagag ggaatggtca gcctgaggct 246421 ccgtaagcca aatgagagta tggtagaatt ccaggtggaa gacaatggcc ccgggatttc 246481 cgagaaaatc ggagacattg tgtttgaccc gggctttact tcaaaatatg acgaatttgg 246541 cacgccttct acgggtatcg gactttccta cgtaaaggaa atcgtgacag agctagaagg 246601 ggatatcacg tttgataatc agcagcgggg agtggtgttt gccatcaggc tgcctgtccg 246661 gcatttgatt cagaaagggt gaaccaaaag ctatgcgttt ttttattgca gatgatgacc 246721 gtgcggtgcg gtcaatttta aggcagatca ttgaggacga agatctcggg gaagctgctg 246781 gtgaagcaga cgacggaagc caagtggaag ggcatatgct gcaatttaag cagattgata 246841 ttttattaat cgatctgtta atgcccggaa gagacggcat tgagacgatt cgtcagatcc 246901 agaatacgta ctccggcaaa atcgtaatga tctctcaagt ggaggcgaag gaaatggtcg 246961 gggaagcgta ctcgctcggc atcgaatatt ttatccataa gccgattaac cgcattgaaa 247021 ttgtcacggt tctccaaaag gtgaaggagc ggatcgagct tgaacactcg attggagcca 247081 ttcagcattc tctaagccgg cttgtcaatc ggactgaacg gaaagcgcgt ccccagcaga 247141 agagtgacag cggtttaaaa gaggcaggaa cattcctgtt gtccgagctg ggcatgatgg 247201 gagaaggcgg cgcacatgat ctcatggcgg tcctgcagta tttagcagaa cacgagcaat 247261 ccgagccgca cgaaaaacaa agcccttcgc taaaacaaat attcacccaa gtagcggtac 247321 ggaagctggg gacaggagcc tcacagacgg aagtcaatcg cgaaatgaaa gcctcggagc 247381 agcgtatccg cagagcgatt attcattcgc tgcaccattt tgcttcactg ggcacaactg 247441 atttttcgaa tccaaaattt gaaacctatg catcgaaatt ctttgatttt ccggttgtca 247501 gccagaaaat gaaagaactc caatccaagg atgcaaaacc ccttgcacct gctagaataa 247561 atatgaaaaa attcatccac gtgttttttt tggaagcaaa gcttttgcat gagacgatga 247621 aacaaagaag gatataaacc aaacagccgg ctgaccaggc tgtttttttg ctgcgcagaa 247681 tcccggccgg acagtgattt accgcttttt tataaaatat cagaaaataa agatattgac 247741 ttattgttta tttgtcttac aattaaacaa aaggatatat gggaaggagc ggatgtgaaa 247801 gaaaaattaa taaaagcgct tacagataga ggccgtatac acaaataaca ggaggttatg 247861 ttgatgagcc gtatcagaaa agcacccgct ggaattttag gttttccggt tgctcctttt 247921 aacacacaag gaaaactgga ggaagaagct ctttttcaaa acattgagtt tttgctgaat 247981 gagggcttgg aagcgatatt tatcgcttgc gggtctggtg aattccaatc tctcagccag 248041 aaggaatatg agcaaatggt ggaagtcgca gtctcggcag ccggaggaaa ggtgccggtc 248101 tacacggggg tgggcggcaa cctcagcaca gcgcttgatt gggcgcagct gtcggagaaa 248161 aaaggcgccg acggctactt gattctgcct ccgtatttgg tgcatggcga acaggagggg 248221 ctgtaccagt atgcgaaaac gattattgaa agcactgact tgaacgcgat tctttatcag 248281 cgcgataacg cagttctctc tgttgaacag atcaaacgtc tgaccgaatg tgaacagctt 248341 gtcggtgtca aagacggggt aggaaatatg gatttgaata tcaatctcgt ctatacgatc 248401 ggcgaccgct tgggatggct caacggaatg ccgatggctg aagtgacgat gccggcttat 248461 ctgccgatcg ggttccactc ttactcttca gcgatttcaa attatatccc gcatatttcg 248521 cgaatgttct atgatgcatt gaaaaacgga aatgacgagc ttgtgaagga actctatcgg 248581 catgtgattc tgccgatcaa cgacattcgc aaacaacgaa aaggctacgc cgtatccttg 248641 attaaagccg gtatggaaat catgggtttg aatgtaagga atacagccag accgcctgtc 248701 ggcccggttg aaaaagatca ttatcagcaa ttggaagcaa ttttgaagca ggcggctgac 248761 cgttttccga aaaaagccgc gacggtttga ccagaaaaaa cacgaaaggg gcaatgggca 248821 tgtctgtgat cacggaacaa aacacgtacc tcaactttat taacggagag tgggttaagt 248881 ctcaatcagg cgatatggtc aaagtcgaaa accctgccga tgtgaatgat attgtcggat 248941 atgtacagaa ttcaacggct gaagatgtgg aacgtgccgt caccgccgcc aatgaagcca 249001 aaacggcttg gagaaagctg acgggtgccg agcgcggcca atacttatac aaaacagcgg 249061 atatcatgga gcagcgcttg gaggaaatcg ccgcctgtgc aacgcgtgaa atgggtaaaa 249121 cattgccgga agcgaaggga gaaacagccc gggggattgc cattctgcgc tattacgccg 249181 gagagggcat gcgaaaaacg ggtgacgtca ttccgtctac tgacaaagac gcgctcatgt 249241 ttaccacccg tgttccgctc ggtgtggtcg gtgtgatttc tccgtggaac ttcccagtgg 249301 cgattccgat ttggaaaatg gcgccggcat tggtatacgg caataccgtt gtcatcaaac 249361 cggcgacaga aacagctgtg acatgcgcga agatcattgc ctgctttgag gaagcggggc 249421 tcccggcagg ggtcatcaat ttggtgacag gcccgggttc tgttgtcggg caggggcttg 249481 ctgagcatga cggtgtaaac gccgttacgt ttaccggttc aaatcaagtc ggaaaaatca 249541 tcgggcaagc cgctttagcg aggggagcca aatatcagct tgagatgggc ggcaaaaacc 249601 ctgtcatcgt agctgatgac gctgaccttg aagctgcggc agaagctgtc ataacggggg 249661 ccttccgttc aaccggccag aaatgcaccg cgacaagccg tgtcatcgta caaagcggaa 249721 tttacgagcg ctttaaagaa aaactgctcc agcgcacaaa agatattaca atcggagaca 249781 gcttaaaaga ggatgtctgg atgggaccga tagccagcaa gaatcagctt gataactgcc 249841 tgtcatacat tgagaaaggc aaacaggagg gcgcttccct tttaatagga ggagaaaagc 249901 tggagaacgg aaagtatcaa aacggctatt atgttcagcc tgccatcttt gacaatgtga 249961 catctgagat gacaattgcc caggaggaaa ttttcggtcc ggtgatcgcc ttgatcaagg 250021 tggactcgat agaggaggcg ctgaacatcg ccaatgatgt gaagttcggt ttaagtgcat 250081 ccatcttcac ggaaaacatc ggccgaatgc tttctttcat tgatgaaatc gatgccgggc 250141 tggttcggat caatgcagaa agcgcaggtg ttgagctgca ggcgcctttt ggcggcatga 250201 agcagtcgag ctcccactcc cgagaacagg gtgaggcagc gaaggacttt ttcacagcga 250261 tcaaaactgt ttttgtgaag ccgtaatggt gctggaaaga ggcgtgcgtc tctttcccgg 250321 tttatcacaa ccagcatatg attctctact ttgaaaagga gaagatacta tgaaaaaaga 250381 ctttgcgagt gttactccgg cgggcaaaaa aacgtccgtg cgctggttca tcgtgtttat 250441 gctgtttctt gtgacctcta ttaactacgc ggatcgagcg acgctttcca tcaccggaga 250501 ttccgtccag cacgatttgg gattggactc ggtcgccatg ggatatgtct tttctgcctt 250561 tggctgggcc tatgtcatcg gacagcttcc gggcggctgg ctgctggacc gttttggttc 250621 aaagactatc attgcgttaa gcatcttttt ctggtcgttt tttacgttgc tgcaaggggc 250681 gattggcttt ttctccgccg gcacagcgat tatcctgctg tttgcactgc gttttctggt 250741 tggtttatca gaagcgcctt catttcccgg aaacggcaga gttgttgcct catggtttcc 250801 aagctccgag cgcgggacag cttcagcctt ttttaattca gcacaatact tcgcaatcgt 250861 cattttttct cctttaatgg gctggcttac ccactctttc ggctggcatt ccgttttcgt 250921 tgtcatgggt attgcaggca ttcttctggc tgtcatctgg ctaaaaacgg tgtatgaacc 250981 gaaaaaacat ccgaaggtta atgaagctga gcttgcgtac atcgaacagg gcggcgggct 251041 gatttccatg gatgacagta aaagcaaaca agaaacagaa tcgaaatggc cgtatatcaa 251101 acagctgtta acgaaccgca tgctgattgg cgtgtacatc gcgcaatact gtattacgac 251161 tctcacctat ttctttctca catggtttcc ggtatatttg gttcaggccc gcggcatgtc 251221 tattcttgaa gctgggtttg tcgcttccct gccggcgctg tgcggatttg ccggcggcgt 251281 gcttgggggc attgtgtcag acatcttact caaaaaaggc cgttcactga cctttgcaag 251341 aaaagtgcca atcattgccg gcatgctgct gtcttgcagt atgattgtct gtaactacac 251401 agattcagca tggctcgtcg ttgtcattat gtcgctcgcg tttttcggaa aaggcttcgg 251461 cgcattgggt tgggctgtcg tgtcggacac gtctccgaaa gaatgtgcag gattaagcgg 251521 cggtttgttc aacactttcg ggaatattgc ctcaattaca acaccgatta ttatcggata 251581 cattgtcaat gccactggat ctttcaatgg cgcgcttgtg tttgtcggcg ctaacgcgat 251641 tgcggcgatc ctcagctatt tgctgctggt cgggccgatc aaacgggtcg tgttaaagaa 251701 acaagaacaa gaccccgatc aatcgttgcc tgtctaatat ttatgaaagc gctttataaa 251761 gggaggaaaa tgcatgagtt caccgataca agagcaggtt caaaaagaaa aaagatcgaa 251821 tattccctca atttctgaaa tgaaggtgat tcctgttgcg ggacatgaca gcatgctgct 251881 gaatctaagc ggagcacaca gcccgttttt tacccggaat atcgtaatct taacagacag 251941 cagcggaaat cagggagtcg gcgaggtgcc tggcggagag catattcgcc gcacactgga 252001 gctgtcagag ccgcttgttg tcggaaaatc tatcggtgcg taccaggcga tattgcaaac 252061 ggtcagaaag cagtttggcg atcaggacag gggagggcga ggaaaccaga cgtttgattt 252121 gcgcaccact gtgcacgccg tcaccgcact ggaagcggct ttgttggatt tgcttggaaa 252181 gtttcttcag gaaccggtcg cggctttgct gggcgaaggg aagcagcgtg atgaagtaaa 252241 aatgctcggt tacctctttt acatcggcga ccgaaatcgg acgaccttgc cgtatcaaag 252301 cgatgagcag tcagattgtg cgtggttccg tctgcgccat gaggaagcgc tgacgccgga 252361 ggccattgtg cgtcttgccg aatccgcaca ggagcgctat ggctttcagg atttcaaatt 252421 gaaaggcggg gtgctgcggg gagaagagga aatcgaagct gttaccgcat tatcgaaacg 252481 ttttccagag gcaaggatca ctcttgatcc gaacggggca tggtcattag aggaagctat 252541 tgcattatgc aaaggaaagc aagatgtgct cgcgtatgcg gaagatccat gcggggatga 252601 gaatggctac tccgctcgtg aagtaatggc tgaattccgc cgcgcgacag ggcttccgac 252661 tgcgacaaat atgattgcga ctgactggcg ggaaatgggt cacgcgattc agctccacgc 252721 ggtcgatata ccgctggctg atccgcattt ttggacgatg caagggtcgg tgcgggttgc 252781 gcaaatgtgc catgattggg gtttgacatg gggctcgcac tccaacaacc actttgatat 252841 ttcccttgcg atgtttaccc atgtggcagc agcggctccg gggcggatca cggcgattga 252901 tacccattgg atctggcagg acgggcagcg attaacgaaa cagccttttg agatttcttc 252961 tggctgtgtc aaggtgccgg ataagcctgg actaggcgtc gatattgata tggaacaagt 253021 ggaaaaagcg catgagatct atcggaaaat gaatttaggc gcacggaatg atgcgatccc 253081 aatgcagttc ctgatcagca actgggaatt tgaccggaag cgcccgtgtc ttgtgcgata 253141 agtttgattg taaatattgt catatccgct attttgtctt acaattgaac aactgaaggg 253201 agagttgttc gtgtacgaag gtttagagga tttgaaagtc gatacagtca atcggaaaac 253261 attagccaag caggtcatcg aacggattgt ccatttatta tcgagcggac agttgagggc 253321 cggagacaaa ttgccgacag aaatggaact gatggacatt ttgcatgtca gcaggccggt 253381 gctacgggaa gcactcagtt cacttgaaac gctgggcgtc attacgagaa aaacacgagg 253441 gggcacatat ttcaacgata aaatcggcat gcagccattt tccgtcatgc ttgctttggc 253501 cactgataat cttccggcta tcattgaagc gcggatggcg ctagaactcg ggctcgtgac 253561 aattgccgcg gaaaaaatca atgaggaaga gcttcagcgt ttgcagaaga cgatcgacga 253621 tattgccaac agcactgaca atcattatgg tgaagcggat aaagagttcc atcgaattat 253681 tgcgttaagc gccaataacc ccgtcgttga agggatgatt cagtccctgc tgatcaccca 253741 tgcgaaaatt gacagccaaa ttccgtacag ggagagagat gtaacggtcg aatatcacaa 253801 aaaaatctac gacgcccttg ccaaaagaga tccgtacaaa gcacattacc acatgtatga 253861 gcatctgaaa tttgtccgtg acaaaattct aaaaggaatg gatgaaaaat aatggtgagc 253921 aaccgcagtt gaaacgtaag agctgcggtt tttttaaacc aatttagaaa acgcttacta 253981 aaatatgagg agtgattttc atatggcgat gaacctcagg aagaaccaag ccccccttta 254041 catcaaagtg catgaaatag ataacaccgc gattattgta aatgatggag ggctgccaaa 254101 gggcactgtt ttctcatgcg ggctcgtact tgaagaggat gttcctcaag gccataaggt 254161 ggccctcacc gatctcaatc aaggggacga gatcgtgcgt tacggagagg tgatcggatt 254221 tgctgatgag acgatcaaac gcgggagctg gatacgggaa gccctcgtga gaatgcccgc 254281 tcctccggcg ttagacgatc ttcctctcgc aaacagggtg ccgcagccgc ggcccccact 254341 tgaaggatat acatttgaag gataccgaaa tgcggatggc agtgcgggga caaaaaatat 254401 cctcggcatc acgacaagtg ttcaatgtgt tgttggcgtt ttggattatg cagtcaaacg 254461 aataaaagaa gagctgctgc cgaaataccc aaatgtcgat gacgttgtgc cgctgcatca 254521 tcaatacgga tgcggcgtgg cgatcaatgc gcccgacgct gtcattccga tccgcacgat 254581 tcaaaatctt gcgaagcatc cgaacttcgg cggtgaagta atggtaatcg gattgggatg 254641 tgaaaagctc ctcccggaaa gaattgcctc cgaaaatgat gatgacattc tatcgctcca 254701 ggatcaccga ggttttgcgg cgatgatcca atccattttg gaaatggcgg aggaacggtt 254761 aatcaggctg aacagcagaa cccgggtgtc atgccctgtt tcggatctgg ttatcggcct 254821 gcaatgcggc ggcagtgatg cgttttccgg cgtgacggcg aaccctgccg tggggtatgc 254881 ggctgattta ttggttcgcg caggtgcaac ggttttgttt tctgaagtga cagaggtgcg 254941 ggatgccatt catttattaa cgccgcgggc tgtcagtgaa gaggtcggac aatcgctgat 255001 caaagagatg aagtggtatg acagctatct tcggcgggga gacgcagacc gtagcgcaaa 255061 cccgtcacca ggcaataaaa aaggcggatt atccaatgtg gtggaaaaag cgttaggttc 255121 ggtagcgaaa tcaggcacaa gccccatctc cggcgtgctc ggccctggtg aaagagcaaa 255181 gcaaaaaggc ctgctgttcg cggcgacacc ggcaagcgat tttgtgtgcg gcaccctgca 255241 gctggctgcg ggcatgaatt tgcaggtgtt tacgacaggg agaggaacac catatggcct 255301 ggctgctgcg ccggttctga aagtatcgac gcggcattcc ttatcagagc attgggctga 255361 tttaatcgat atcaatgccg gccgaatcgc gacaggagag gccagtatcg aagacgtagg 255421 ctgggaaatc ttcaggacga ttttggatgt ggcaagcggc cgcaaacaaa cgtgggcaga 255481 ccgttggggt cttcataatg atttgtgctt gtttaatcct gctccagtga cttgattcat 255541 gtttttatag cggaaagatg gaatatgctg taaaatgaaa atcagcgtat aggaaacgga 255601 ggggttacag catggcattc attagattcc gagtgacacg aattcaatag tgaacaactc 255661 tcgcctgaat gcgagagaat cgggatgaat ccgcctatgt atgagccctt atatggttat 255721 caaaaaagag ggtggcgtgc ctgccctttt ttgtgccttc aagcatccct tctctctact 255781 gcaggccgga gcatgagaaa ggggaaatgg gatgacaaac cttaacgaaa aacagcttat 255841 cactgagatt gtcgggcttg cacgcagcca aggtttgacg gttcattctg agaacgcgca 255901 attgaatgaa accggaatgg actttcaagt tgtatttgcc aaggacgaca caggtatgcc 255961 atgggtgctg cgaaaaccgc ggcgaagtga tgttgtggaa agagcatctg cagaaggcat 256021 aacgcttgcc tttctccgcg cgaatctgac tgctgatgtg ccggattgga gaattcatac 256081 accggaattg atcgcttacc ccatgttaaa aggaacgccg gctgctggaa ttgacttgga 256141 acaaaagcaa tatgtatgga atatggatca tcagccgccg tcagacgact ttgtccgcac 256201 acttgccgac atactggctg aattacatgg cacggatcaa atatctgctg ggcaatccgg 256261 aatagaagtg ataaggccag aagatttcag gcaaatgaca gcagactcta tggttgatgt 256321 gaagaataag cttggcgtat ctacgacgct ttgggaaaga tggcaaaagt gggtagatga 256381 tgatgcatac tggccgggtt tctcttcttt gatacacggc gatctccacc cgccgcatat 256441 ccttatcgat caaaatggac gtgtcacagg acttctggat tggacagaag cgaaggttgc 256501 tgacccagcc aaggattttg ttctttatca aaccattttc ggagaaaaag aaactgcccg 256561 tttgcttgaa tactatgatc aagcaggcgg ccgaatatgg gcaaaaatgc aggaacacat 256621 ctcagagatg caggcggcgt atccggtgga aatcgccaag ctagctctgc aaacacagca 256681 ggaggaacac atcaatatgg cgctggaagc acttggtgta acatcggatt aagaattgac 256741 ttcgtttcat gaaccgagta ttataaactc tacaaataat agaacggatt aacaatcgtg 256801 aggaagagca agtacgcatc agaatggagg ttcagagagt cggtggcagg tgtgaaccga 256861 tcctcccctg atgccgaatg ggcttctgaa ttgctttgct gaacggatag taggcgatgc 256921 cgggtttctc tccccgttac caagagagga gtatcgaaac ataggttttc tgtacttaga 256981 gtgaacggct gtatagctgt taataaaggt ggtaccgcga gaccctcgtc ctttgcatag 257041 gacgggggtt ttttgtgttt cttaaaggag gtgacggcca atgtacgatg gctggtggtg 257101 gcatagcaga tgagttagaa aggaggatat caaatggtca ttgcaactga tgatcttgag 257161 gtcgcatgtc ctaaatgtga aagagcggga gaaatcgaag gaacaccttg cccggcctgc 257221 agcggaaaag gtgttattct gactgctcaa ggatatacgc ttctcgattt tatccaaaag 257281 catttgaata agtaaaggag aaaagctgag ctgagatgag agcagaagag cagagtaaga 257341 ttcgtgaggc cgcagcaggt acgatttttt tgctgatcgg aacagtttgt tttgcgtcta 257401 aatcgatttg gataaaatgg gcataccaaa tgggtgctga gccagatgcc gtgctgctat 257461 acaggcagct gctggctgtt ccgctgtttt ggctgatttt tttaatatac cgtcctccaa 257521 tgccagacgg taagaaaaaa ggagacctat ggaaggcttg tggcgcggga gtgttttgtt 257581 tttttctgtc tcccttgctt gattttatcg ggctgaacca tgtatccgca atggttgaac 257641 gtatattgct gatgagctat ccgttgtttg tgtttggatt caccgcgtgt cgtgaccgga 257701 aaatgtcctc aattcaggac cttttcgcag ttctggcggt catgtttggg cttttcttgg 257761 cgctgggcgg ctggaatgct gagcttttcc aggcgaatat gattggagct gtattcattt 257821 tgttatcttc ggccgtctat gctggttatc ttgtcctttc cgggcatctc gtccatcaaa 257881 tcggagggat ccgtctcaat gcatacggga tgacagctgc tggagctgcc atgatgcttt 257941 acacagggat aaaatcggcg gctggcatga atacgccaat ggcagcatat ccgctttcta 258001 tgtatggttt gttcgcagta attgcagtcg ttaccacagt gattccattt gtgctaatgc 258061 ttgagggcat aaaacgaatc ggggcacagc gagccgccgc catttcaatg gcagggccta 258121 tcctgacgat tttctatgga gctttatttc tcggtgaacg gctcgggctc attcaagtca 258181 ttggatgcgg tggcgtattt tttgtcatta cgggcatgga atacaggaag ctgaaaacag 258241 gaaaaaaaga ataattttta taaaacacac acgtttttca attacaataa gtgtaattac 258301 gtgtgtgttt tttgattttg taaaggttag gtgaggagat gcagcgcata ttgcttgtag 258361 aagacgacca ctcaatcagt gaaatggtgg atcattattt aacaaaagaa ggctttggaa 258421 ttgtgcatgc tttcgacgga gaagagggca tccggctgtt tcagcagggt tcatacgatt 258481 tggtcctcct tgatatcatg ctcccgaagc tgaacggcat ggattttctg aaaatcatcc 258541 gggaaaaaag caatataccg gtcttaatga tttcggcaaa agatggagat gtggacaagg 258601 cattgggact gggctttggg gcggatgatt atatcgccaa accgttttcg atgattgagc 258661 tgacagcccg agtaaaagcc gcgatacggc gggcgacgca atattcggca gaggagccgg 258721 ctgtgaataa ggtgatccgg attcaccagc ttgcgataga tatagacaat gtttccgttt 258781 tgaaaaacgg agagccgctc cagctgacgt caacagaatg gcagctgctg tgcttatttg 258841 catcaaatcc taaaaaagtg tttacgaaag aacaaatcta ccgttccgtt tggaatgaag 258901 agtactttga tgatcagaac atcattaacg tacatatgcg gcggctcaga gaaaagattg 258961 aggatgaccc ctcctcccct caatatatta aaacgttatg gggcatcggt tataaattag 259021 gagagtttta gaatgacagt gctatgggtg gccgctgtca tcgctctggc gtgtctgaat 259081 gtgattcaat tcataatgaa aaagaagcgg gacgggaatc tggcttacac ggctgaccag 259141 cttagctaca tgctcagccg ggattcggca ggacaaattt tgcttcctac agacgatcat 259201 gcgctcaaag acttgcttgt taacatcaat cttatcgttg agaatcgtca gcagatcagc 259261 gcccaatttg ccaaaacaga gcaatccatg aagcggatgc tgaccaatat gtcgcacgac 259321 ctgaaaacgc cgttaacggt cattctcggt tatattgaag ccattcaaag tgacccgaac 259381 atgccggacg aagagcggga aagattgctg gggaagctcc gccagaaaac aaatgaactt 259441 attcagatga tcaattcctt ttttgattta gcgaaattag aatctgaaga taaagagatc 259501 ccgatcacca aagtacatat gaacgacata tgcaaacgaa atatcctgca ctattatgac 259561 gctgttcagt caaaaggctt tcaagcagcc atcgatatcc ccgatacgcc ggtgtatgcg 259621 caggcgaatg aagaggctct ggacagaatc ctgcaaaacc tattgtccaa tgcgattcaa 259681 tatggcgcgg ccggcaagtt aatcgggctg acgctgtctt atgatgagag gaacatcgcc 259741 atcaccgtat gggatcgcgg aaaagggatt agtgaaaccg atcagcagcg ggtgtttgag 259801 aggctgtaca cactggaaga atccagaaat aaagcatttc aaggaagcgg cttgggttta 259861 accatcacaa aacggcttac agaaaaaatg ggaggcatca tatccgtcca aagcaagccg 259921 tacgaacgga ctgcatttac gatcacattg aaacgcatga catattaatc gtaagaattt 259981 cttaaggttt gagaaataaa aatgacaggg ctcgccgcta caatagaaaa caggaaaaga 260041 gagggaagga gaaacaaagt tgacttatat cgtacaaaca aacgggctga ccaaaacata 260101 tcagggcaaa gaggtcgtat ccaatgtcag catgcatatt aaaaaaggtg aaatctatgg 260161 ctttctcggc ccgaacggcg cggggaaaac aaccattatg aaaatgctga cgagccttgt 260221 caaaccgaca agcggtgaaa tcatcatcct tgggaacaag ttcacccaca cgtcatatga 260281 ggtgctgggg aacatcggca gcatgattga atatccgatt ttttatgaaa acctgacagc 260341 tgaagaaaat ttagatctgc attgtgaata tatgggatac cacaataaaa aagccataca 260401 agaagtgctg gatatggtga atttaaaaca aatcgacaaa aaacccgtca aaaccttttc 260461 cctcgggatg aagcagcgcc ttggaattgc gcgtgccatc ctcacgaagc cggacctgct 260521 tattctggat gagccggtga atggtcttga ccctctcggc attaaaaaga tcaggcaatt 260581 gtttcaagtg ctgagcaaag agtacgggat gacgctgctg atctcaagcc acctgctggg 260641 tgaaatcgaa caaatcgcgg acacaatcgg cgtcattcgg gacggcaggc tgcttgaaga 260701 ggtatcaatg gaggatgtca ggggccagaa cactgaatac atcgagcttg tcacgccgaa 260761 tcagacaagg gcctgctttg tgctggagaa agagctgcaa ttaaccaact ttaaaatatt 260821 aaatgagaaa acgattcgaa tttacgaggc tgaagcctct caggctgcca tatccaaagc 260881 attgatttta aatgatgtag acattgaatc aatgaacaaa aagtatacgt cgctggagga 260941 ttattttatc aaattgatca acggcaatag catcagtgcg taaaggagga gagacacgtt 261001 gatgaatttg atcagaatcg aattaagaaa aatgaaaatg ggctggtata tcagaggtgc 261061 cctcattgcc aacgtgatca ttatgggttt tatgtggctg atcagttatt ccgaaaaagc 261121 cgatggcggg gtttcgttcc aaagtacgga tgaagcattc ctcatcatcg gcaccttcgt 261181 cagagcggta tttatcgtat ttggcgctgt gctgatcgta aaattggtga tttcggaata 261241 taaaaacaaa accattcttg tgatgttcac gtacccgatc agccgtaaaa agctgctcac 261301 cgctaagctc atgatcgcgg gcggactgac gtttatcacg attttacttt caaatatact 261361 catagccgcc ggtttctttt ggctgaactc gatctgccat ttcataccgg gagagcttac 261421 ttccgagatc atttctcaac aggcggtcaa aatggcggtt ttcgcttttg gcgccgctgg 261481 aaccagttta gttcccatct tttttgggat gcgtagacac tcggttccgg cgaccatcat 261541 ttcatctgta gtaattgtga tgctcatcag ctcaacaagt ccgggcttct cgatttcatc 261601 tgttgtgtat atcccgttat cgttagcggc attcggtttg ttcttttcct acatggcgat 261661 caggaatgcg gacaagcagg atgcgtaaac aaaggcgccc aatatgtata aaaggccgat 261721 gctgtcagca ccggcctttc cattatgagt ctgttcttgt ttcaagataa tgcttcttgc 261781 caatctcttt gctcatcata tagaaatgga agcaatattc accgattgcc atgacgatcg 261841 cgccgaataa agccgccaat gcaacttcac cgccagtcat ccccatagaa agcggcatgc 261901 ccatcagcca gatcacgaga aaggccaaac caaaatcagc caaagttgca atcatattat 261961 tccatttcgg caatacataa agatcgccca gcaaataaga aataacccct aacacaatcg 262021 tcattagcag cgtatcacca aacgtgaaac caaagcccag accaagcacc agatacaaca 262081 caataatcgt cataatacct ttaatagcga gcgctttcac atgtgtcatt acaattcctc 262141 cttttgtcat ttgatttgtt atgtataatt cctcaaatgt aaaaagttaa accttatttc 262201 ttttcggagg cgggtgcaaa tctgctgggg agaggtcaat gatgtgaatc caggaattga 262261 ggctgcggcg cttcgacagc ggaaacgtga agcttgtact gcaccggacg ctgctttgat 262321 gcccaacagc ccattatgtt tgctgttttt agatgaataa atttaaaaac ttctcctgtc 262381 cctccgtcat cacttctgaa gtaatgaaat atgatgaaaa gagatcaagg ggaggtgacg 262441 tgatggcggt cgtgagagca acgagtgcgg atgtcgattt gatggcaagg ctgctcagag 262501 cggaagcgga aggcgaaggc aagcagggga tgctgcttgt cggcaacgtt ggaattaatc 262561 ggctgcgggc gaattgctca gattttaaag gcctccgcac catcaggcag atgatttatc 262621 agccacacgc gtttgaggct gtgactcatg gatattttta tcaaagggcg cgagatagcg 262681 agcgtgccct tgcacgccgg tcgattaatg gtgaaaggcg ctggcctgca aaatttagtt 262741 tatggtactt caggccgcag ggggactgtc cagcccagtg gtataaccag ccgtttgtgg 262801 ccagatttaa gtcacactgc ttttatcagc cgacggcgga gacgtgtgaa aatgtatata 262861 acacatttta gagacaggac accgttcaaa ttgaacggtg tttttctttg aaaagatgca 262921 atgcaaaata ttcctgtgag ataatcaaag aaaaaagagc tgacggagat gacagaatgg 262981 caacaattga cctgcaaaag aaaagtgtaa agatcgtact ggagaaaaag cagttaacga 263041 aggtgacggc tcgtgttgga ctggttcttg atattacggg atcgatgaga ccgctctaca 263101 aaaacgggac ggttcaaaat gtggtggagc ggattttggc agtggctgat cagtttgatg 263161 ataacggttt gctggatgta tgggtgtatg ataatgaatt ttcccgatta aagccagttt 263221 cagaaaagga tttttcgggc tatgtcgatc gtgaaatttt aaataatgac cgcttgcata 263281 aattcggcag aaatgatgag ccgccagtca tgaaggacgt gctgcgcaaa tatgttacgg 263341 aggaaccgag ctcgtatcct gctttcattg tttttatcaa tgacgggggc tgtaaaaagt 263401 caatcaaacc gataattgaa gcttcttctg ataaaccggt gttctggcag tttgtcggca 263461 tcggaaacgg aaactttgat tttctcaata aactggatac gttagaaggg cgtgtcattg 263521 ataacacgaa cttcctgcat atcgaagaga ttgaccgcat ttctgatgat gagctttatg 263581 atgctctgct tgctgaattt ccattttggc tgaaagaagc gaaggaaaaa gggattgtaa 263641 gagaacaaga gcctcctgct gaaaagccga aaaagaaggg ctttttcagc agattgtttt 263701 cgaaataact gataaagagc actgagtcat tctgcgaaat ggctcggtgt ttttgttttt 263761 ttaagatcat gtgaagaaaa ataggccgaa tgggcggctt gcaaacgaca ggatatgcag 263821 aaaacgcgtc attcagccag ctttcggcat gtttcagcag caggcttgtg agggaagacc 263881 tgtttttaat gttcagcgct tacaatcagt tcacacttct tcacagtcgt ttaacaatga 263941 tttcctataa tggagacgat caatgaggag agaggggatc ttgaatggca tacgacagtc 264001 gttttgatga atgggtacag aaactgaaag aggaaagctt tcaaaacaat acgtttgacc 264061 gccgcaaatt tattcaagga gcggggaaga ttgcaggact ttctcttgga ttaacgattg 264121 cccagtcggt tggggccttt gaagtaaatg ctgcgcctaa cttctcaagc tatccgttta 264181 cattaggggt agcgtcaggt gatccgcttt ctgacagtgt cgtgctttgg acacgtctgg 264241 caccagatcc gctgaatggc gggggaatgc cgaagcaagc agtgcctgtc aaatgggagg 264301 tcgcaaagga tgagcatttc cgcaaaatcg taagaaaagg cactgaaatg gctaaaccaa 264361 gtcttgccca ttccgttcat gtggaagcgg acgggcttga gccaaacaaa gtgtactatt 264421 accgtttcaa aaccggccat gaactaagcc ctgtcggaaa aacaaaaaca ctgcctgccc 264481 ctggcgccaa tgtgccgcaa atgacctttg catttgcttc ctgccagcaa tatgagcacg 264541 gatattatac ggcctacaag catatggcaa aggaaaagct tgatcttgtc ttccatctcg 264601 gtgattacat atatgaatac ggcccaaatg aatatgtatc aaaaacaggc aatgtccgca 264661 cgcacaacag cgcggaaatc attacgctgc aagactatcg gaaccgtcac gctcaatacc 264721 gttctgacgc caatcttaaa gctgcacatg cggcattccc ttgggttgta acttgggatg 264781 accatgaagt tgaaaacaac tatgccaata aaatacctga aaaaggacag tcggttgaag 264841 cattcgtgct ccgccgcgcg gcagcatacc aggcatacta tgaacatatg ccgctccgca 264901 tttcctcttt gccgaatggc ccagatatgc agctgtaccg gcactttacg tacggaaacc 264961 tggcgtcctt caatgtgctt gatacccgcc agtacaggga cgaccaagcc aataacgacg 265021 gcaataagcc gccttctgat gaatcgcgca atccgaatcg gactctgctt ggaaaagaac 265081 aggagcagtg gctcttcaac aatttgggca gctcgacagc ccactggaat gtgctggcgc 265141 agcagatttt ctttgccaag tggaatttcg ggacaagcgc aagcccgatc tacagcatgg 265201 attcgtggga cggctacccg gctcagcgcg aacgggttat caatttcatt aaaagcaaaa 265261 atctgaataa tgttgtcgta ctgacaggtg atgtacacgc aagctgggca tcgaatttgc 265321 atgtcgattt cgagaagaca agttcaaaaa tattcggagc cgaatttgtt ggaacctcga 265381 tcacttccgg agggaacgga gcggataagc gagcggatac ggaccaaatt ttaaaagaaa 265441 atccgcacat ccagttcttt aacgactatc gcggatatgt ccgctgtaca gtgacgcctc 265501 accagtggaa agccgattat cgggtgatgc catttgtgac cgagccgggc gcagccattt 265561 ccacgcgggc ttcattcgtt taccagaaag accaaaccgg gttgagaaag gtatcatcca 265621 caacaatcca aggcggggtg aagcaatccg atgaggtcga agaggatcgt ttcttttcgc 265681 acaacaaagc ccacgaaaaa caaatgatta agaagcgtgc aaaaatcacg aattaaggag 265741 tggaaattat gttttcaaac attggaatac cgggcttgat tctcatcttc gtcatcgccc 265801 tcattatttt tggcccttcc aagctgccgg aaatcgggcg tgccgccgga cggacactgc 265861 tggaatttaa aagcgccaca aaatcacttg tgtctggtga tgaaaaagaa gagaaatcag 265921 ctgagctgac agcggtaaag caggacaaaa acgcgggctg aatgctgatg aggcagacac 265981 cgggtctgcc tcttttttta tgaaagggag ggcttttttg aatggataaa aaagaaaccc 266041 atctgatcgg gcatttagaa gagcttcgcc gccggattat cgtcaccctt gcggcatttt 266101 ttctatttct catcacggct tttttgttcg tacaggacat ttatgactgg ctgatcaggg 266161 atttggatgg aaagctggct gtgctaggac cgagtgaaat cctctgggtg tatatgatgc 266221 tttccggcat ttgtgccatt gcggcttcta tccctgttgc cgcgtaccag ctgtggcgtt 266281 tcgttgcacc ggcgctgact aaaacggagc gcaaggtgac gctcatgtac ataccaggtt 266341 tatttgcgtt gtttttggcg ggcatctcct tcggatactt tgtcttgttt ccgatcgtgc 266401 tcagcttttt gactcattta tcctccggcc actttgaaac gatgtttacg gctgaccgct 266461 actttaggtt tatggtgaat ttgagcctgc cgttcggctt cttgtttgag atgcccttgg 266521 tggtgatgtt tttaacaagg ctgggcatct taaatcctta cagactggcc aaagcgagaa 266581 agctttccta ttttctgctg attgtcgtgt ccatattgat tacaccgcct gattttattt 266641 ctgattttct cgtgatgatc ccgcttcttg tcctgtttga agtgagtgtc accctatcgg 266701 cgtttgtcta caaaaagagg atgagggaag aaacagcggc ggccgcttag tgcagcgtac 266761 cacccggtga cttcacatcc tcatcatatt gtgcggccgt aacagcggcg attctcaatg 266821 cccggacaat cgtgtccagg ctgaggctcg gcgctgtttt gtcgattgtt tgctgcggaa 266881 tgtaaggaat atgaataaaa ccgccgcgaa tgtgtgggga tgtccggcta atgtgatcca 266941 ttaacccgta gaacaaatag ttgcatacaa aggtccccgc tgtgtaggaa accgcagctg 267001 gaatgccgtg ttccttcatc ttagcagtca ttcgtttcac gggaagcctt gtccagtaag 267061 cggcgggccc atctggagaa atctcttcat caatcggctg atgtccttcg ttatcgggga 267121 ttcgcgcatc tgcaaggttg attgccactc gttccggtgt aatctgcatc cgtcctcctg 267181 cttggccgac acaaattacg atatctggct gatgtttttg aatggcttgg cgcagagtgt 267241 ccagagcgga tctaaagacg gttggaattt gttccgctgt aataatggct tcttctgtct 267301 cgaagccatt aagccgtttc gccgcttccc atgatggatt gacggtttct ttgtcaaaag 267361 ggtcaaagcc tgtgatcagc actttttttc tcattctccc atctcctttt tcttttattc 267421 tattgtttat ttatgggttt ttcatcaaaa taatgtaaag gagtgaatca taatggagca 267481 tttgccggag cagtatcgcc agttattccc aaccttgcag acgcatacga tgcttgccag 267541 ctgttctcag agcgcattgg cagagcctgt atcaagggcg atccaggatt attatgatag 267601 cctgctgtat aaagggacga actggaaaga agcgattgaa aaaacagagt ttgcgagaaa 267661 cgagtttgca aagctgatcg gggctgaacc ggatgaagtg gcgattgtgc cgtcagtttc 267721 tgatgcactg gtttctgtag catcgtcctt aactgcattt ggaaagaagc acgttgtata 267781 tacagatatg gattttccgg cggtgcctca tgtttggcag gcacactccg attataccgt 267841 atccgtcatt ccatcaatag acggcgtgct gccgcttgaa caatatgaaa cgcatatttc 267901 ggatgaaaca gtactgacgt gtgttcctca cgttcattat cgtgacggct atgttcagga 267961 tataaaagcg attgccgaga tttctcagag aaagggctct ttattgtttg tagatgctta 268021 tcaatcagcc gggcatattc ccattgatgt gaaggaatgg ggcgtagata tgctggcagc 268081 aggcacccgg aagtatttgc tcggcatacc gggtgtggcg tttctttatg tgagaaagga 268141 gctggctgac gcactgaagc cgaaagcatc agcttggttc ggaagagaga gcggatttga 268201 tggggcttat gcaaaagtcg cgcgccgttt tcaaacgggc accccagctt ttatcagcgt 268261 atacgcagct gcagcggctt tatcgctgct gaatcatatt ggggtttctc atatcaggga 268321 tcatgtgaaa acgatctgtg ccgatgcagt tcaatatgcc gctgaaaaag gcctgcagct 268381 ggcggcggca caaggtggga ttcagccggg catggttgcg atccgggatg agcgggcatc 268441 ggaaacggcg gggttgctga agaagaaaaa agtgatttgc gcgccgcggg aaaatgttat 268501 ccgtctcgct ccccattttt ataatacgaa ggaggaaatg cggcacgcga ttgatgaaat 268561 cgcggcgaaa acgatccaca agtaaacatg aaaaagcccc tgaacactag tcaggggctt 268621 ttcatattaa tgatctactt taacgcgttt cataaagaaa gcgccaatta aaccgataat 268681 ggcaacaatc attgcaaaca caaatgcgtg ctgtacgcct gctgtcaaag cttgcgggat 268741 gactgccgga tcggcagggt ttttaactgt actcatataa tcatgctggc ctgcagccat 268801 aatgctgacc gcaaccgctg ttccgatagc gccggccatt tgctgcagcg tgttcataat 268861 ggcggtgccg tctggataaa attcacgcgg cagttggttt aaaccgtttg tctgtgcagg 268921 catcatgatc atagaaatcc cgatcatcaa gcaggtgtgc aggatgataa tcagcacagc 268981 tgttgaagtg gtcgtgacat ttgagaagaa ccatagtaca acggtgacaa tcacaaatcc 269041 cggaatgaca agccatttcg gcccgtattt atcgaacaag cggcctgtaa caggggacat 269101 aaatccattt aaaataccgc ccggcaagag aacaagacca gatgcaaatg cagtgaggac 269161 taagccgcct tgcagataca tcggcagaag cagcatagat gacagaatga ccatcataca 269221 aatgaacacc atgatcacac ccaaaataaa catcgggtat ttgaacgcac ggaggttcat 269281 cataggctgc ttcattgtca gctggcggat tgaaaataag ataaggccga caacgccgac 269341 aatcagcgac acgataacag tcgggctgga ccatcccccg gagccttcac ccgcgttgct 269401 gaatccgaat acaatgccgc cgaagccaat cgtcgacagg atgatagaca atacatcgat 269461 tttcggcttt gtcgtttcag atacattttg catatatgcg ataccgaaaa caagcgccag 269521 cacaaggaat ggaagagaga tccagaaaat ccagtgccag ttgagatgct ccagaaccaa 269581 tcctgagaaa gttgggccga tggcgggcgc gaacataatg acaagcccga tcgttcccat 269641 tgcggcaccc cgtttatgag gcgggaaaat caccaagatt gtgttaaaca tcagcggcag 269701 taaaagaccg gttccaagtg cctgaacgat ccttgccgct aataaaaacg agaagctcgg 269761 cgcaagcgcc gcaatgaatg tacctaaaat tgaaaagata agtgacacgg taaaaagctg 269821 tcttgttgtg aaccactgca acagcagtcc tgaaacagga acaaggatac cgagtacaag 269881 caggtagccc gtcgttaacc attggacggt tgccgctgta atgttcaatt ccttcataag 269941 gtcggttaac gcaatattca gcgctgtttc actgaacatg ccgataaaac cggccaacag 270001 caaggaaatc ataatcggca tcactttgta ttgctgagat gctttagctg ttgtttccaa 270061 aatcatttcc cctctctatc aactgcatgt agtatgtcgt tttttttatc tcttcagcag 270121 gtcaggaatg cagctggaga tatgaaggag cggcgtactg ttttttgccg tcaaagataa 270181 aaggatgccg ccttcaatca tcgcgttaac cacagtgctg gcttcttttg cacggctctc 270241 gctgcagcca gtctgccgca gtttttcctc atacacagag gcccattctt tgtaggcttc 270301 atgacaggct tcgcgcaacg gttcgctttt caatgacgtc tcagccgcta gcaagcccac 270361 aggcaagcct tcaatgtctt ccgtacatga aaactggcag gagagctcct tcaaaaaggc 270421 ttgaatgcct tccgctggat cggtgcaggc ttccatgcag tccgcgattt tctgacggat 270481 atactccttc atctcattca cggcttcgat cgcaagctgt tctttacccc cgggaaagtg 270541 gtagtaaaga gagcctttag gcgcgccgct ttcctttata atctggttca gccccgtgcc 270601 gtaataccct tgcagctgaa aaagccgggt agctgccgaa aggattttct cacgggaatc 270661 tccataactc ataacattcc caccttactg aattgcaatc aaaaatatag tgactggtct 270721 attatcttga ttcaatcatc aattgtcaag aaaaattcat tgtatgaaaa gacaaaaaaa 270781 gaaggatatg acaacaaaaa atactgagag aaaagctgac tgatcttttg actgaataga 270841 taaaatgtac aatgattaat catcatatgg atgtaaggag agaaatagat gaaaaaacaa 270901 cgaatgctcg tactttttac cgcactattg tttgttttta ccggatgttc acattctcct 270961 gaaacaaaag aatccccgaa agaaaaagct cagacacaaa aagtctcttc ggcttctgcc 271021 tctgaaaaaa aggatctgcc aaacattaga attttagcga caggaggcac gatagctggt 271081 gccgatcaat cgaaaacctc aacaactgaa tataaagcag gtgttgtcgg cgttgaatca 271141 ctgatcgagg cagttccaga aatgaaggac attgcaaacg tcagcggcga gcagattgtt 271201 aacgtcggca gcacaaatat tgataataaa atattgctga agctggcgaa acgcatcaac 271261 cacttgctcg cttcagatga tgtagacgga atcgtcgtga ctcatggaac agatacattg 271321 gaggaaaccg cttatttttt gaatcttacc gtgaaaagtg ataaaccggt tgttattgtc 271381 ggttcgatga gaccttccac agccatcagc gctgatgggc cttctaacct gtacaatgca 271441 gtgaaagtgg caggtgcccc tgaggcaaaa gggaaaggga cgcttgttgt tcttaacgac 271501 cggattgcct cagcccgata tgtcaccaaa acaaacacaa ctacaacaga tacatttaaa 271561 tcagaagaaa tgggcttcgt cggaacaatt gcagatgata tctattttaa taatgagatt 271621 acccgtaagc atacgaagga cacggatttc tcggtttcta atcttgatga gctgccgcag 271681 gttgacatta tctatggata ccaaaatgac ggaagctacc tgtttgacgc tgctgtaaaa 271741 gccggagcaa aggggattgt atttgccggt tctgggaacg ggtctttatc tgatgcagcc 271801 gaaaaagggg cggacagcgc agtcaaaaaa ggcgttacag tggtgcgctc tacccgcacg 271861 ggaaatggtg tcgtcacacc aaaccaagac tatgcggaaa aggacttgct ggcatcgaac 271921 tctttaaacc cccaaaaagc acggatgttg ctgatgcttg cgcttaccaa aacaaatgat 271981 cctcaaaaaa tccaagctta tttcaatgag tattgaagaa aagaaggcga ataagccttc 272041 ttttttttgg ctttttagga ccaataatga cctctgaatc ttaaaatttc tttaaaaata 272101 agccaaaatt accctttact taattaattt ggtaacgtaa tataattgga gaatttgtta 272161 caaaaaaagg aggatattat gaaatttgta aaaagaagga tcattgcact tgtaacaatt 272221 ttgatgctgt ctgttacatc gctgtttgcg ttgcagccgt cagcaaaagc cgctgaacac 272281 aatccagtcg ttatggttca cggtattgga ggggcatcat tcaattttgc gggaattaag 272341 agctatctcg tatctcaggg ctggtcgcgg gacaagctgt atgcagttga tttttgggac 272401 aagacaggca caaattataa caatggaccg gtattatcac gatttgtgca aaaggtttta 272461 gatgaaacgg gtgcgaaaaa agtggatatt gtcgctcaca gcatgggggg cgcgaacaca 272521 ctttactaca taaaaaatct ggacggcgga aataaagttg caaacgtcgt gacgcttggc 272581 ggcgcgaacc gtttgacgac aggcaaggcg cttccgggaa cagatccaaa tcaaaagatt 272641 ttatacacat ccatttacag cagtgccgat atgattgtca tgaattactt atcaagatta 272701 gatggtgcta gaaacgttca aatccatggc gttggacaca tcggccttct gtacagcagc 272761 caagtcaaca gcctgattaa agaagggctg aacggcgggg gccagaatac gaattaatga 272821 aaaacaaaac cttgaagaat gctattcttc aaggttattc tgctttcagc acaatggttt 272881 tcgcagccat atcatgaacg gtttgttttt tcttcgtaaa tgcggcagtc aaatagatca 272941 ggcgggagaa cacatgcacc cacgctatca ggtaacggac aatggcttgc gggaaggata 273001 tttttttata tgtttcgtcc ctcacgattt gcagcccgat gatttttttg cctagtgtgc 273061 ccttccaatt tgtcagcggc atcagcaaag ggtacacaat cagcatcaat atggcgacaa 273121 taatgacacc ggcggaccca tcgccaaacg taaatccggc tgccaaaatc actgctgcgg 273181 caatgattac atcaagtaaa agagcgcagg cgcgcagcat gaaaccagct agttccaata 273241 gaaacactcc ttaaaatgtt aaataaacac ctaatgattg taaaaaagaa gggcctaaag 273301 tgggaatagg tgataagcct taaatcacaa aagttggtga aaatgtcata ggtaaattgg 273361 cataatcagc cagcttatca cattaccaaa ttctttttta gcccgaaacc aagccctcag 273421 aagttatttt tgttaaaata gaaaagttac aacagaattc ggagggttta ttgtgggaaa 273481 agtgaaacga aatgcccctt gcccatgcgg cagcggcaag aaatataaaa aatgctgcgg 273541 aagtaaagtt gtcgacttcc cggcggaact agcggcaaaa gaagcgaaac aaattcagga 273601 agacttagtg gagtatgcct tcacagtaca tagagaaagc atttcaggct ttatcaacca 273661 gcatgatttt ctttctgcta tggacagaca gacgaaagac atcagcgtat ttaacttagg 273721 aatctgggga atcttcttcc acccgcttgc tggtgagaag acaatcttcg aagagtacct 273781 tcagaaaaaa ggcgattcga tcactcgtcc gaaaacgcgt gagatcgtag aatcatggca 273841 gagcatgacg cctgctttat tgctgctgaa ggacctgaag gaaggcatca ttcactttga 273901 agatgtcatt acggcaaaac aattcgaagt ggaaatggac gccagcaatc aagaccttcc 273961 tccagtggga agcctgattc ttggataccc aatccacgaa gcggaaaaag cagaattctt 274021 catgcagttc acgatcttcc cggtgaagag aacagaagcg ctgatcagca aggtgaagaa 274081 atatgcggat gccgctgtga aggacggcaa aacgccggag gacttcatga agcaggaatt 274141 caacaacgtt ctgttcgcgt tgttagctga gaaagatgaa gagccacaag cagagaaagc 274201 ggaagtaagc actgttgagt gggcaaacga cttggagaaa gaaaccgctg cggctattga 274261 agaaggcatg agcggggaag agtatccgac tgaattgatc ccagctgtta ttgacatctg 274321 gaaaacattc tgcgagaaaa aatcacctgt catcagaaag ccggaagctt ttgcggcggc 274381 agttgaatat tatgtaaacg caatttctct taacggcgcg tccgtttccc aggctaaact 274441 ggcgaaaaaa tacggcgtta gcgcatcaac gatttccagc cgttacaaag aaattgaaag 274501 cacgctgcaa gatgaagcag atcgttttgc acaagcgtta tcctcataat ggaaaaaacc 274561 ttgaaaagcc aggcttttca aggttttttt atttctgaaa cggaattttg atttctaacc 274621 ggaagatggg gtggcggtag gtaaaatcca gcctgccaaa agcgcccttc accagttttt 274681 gaatgatata tgtgcccatg ccttcatgag cgccgttttt cgttgagcgg ccaaacgatt 274741 gataaattgt atcgagcact tttgggtcca tcccgggagt gctgttttca caagtcagta 274801 cataaagccc gctgcgcagt gaagtctcca gtttaatctc tgctttttct cgggcctccg 274861 ccgcgctgtc gagcgcattt tctaatatgt tgccgaccaa gctgacctga tcagcaggcg 274921 aaaacggaag ggaagaaagc ggtgtatgca tatgcagcga aacactcaca ttcgaggcgc 274981 gggctttttc taaaaaatca taaagcaccc ctgcaacgta cgcgttctct cctttcaaaa 275041 aacggtcata ttggctgtat tgatccgccc agttttgaat atatgcttgt gtatctgcct 275101 tgggctgagc tgatttgatt gcagtgatat gtttcattgt gtcatgattc cggcttctga 275161 catcaatcag catttgattg gcgtgctgtt cagcttgagt cagcttatca atttgatcag 275221 aaagccttgc ctgcaaagca gactgtccga tacggagccc ttcacaccct gcaaatatcg 275281 cgattacaca taataccggc atgatgtctg tgccaatcaa caccactccc accgacatca 275341 cttgaatcac cgcaatccac gcacaaagcc ctgaggaaca gtgtttccac acccgcttcg 275401 tattccaaat gtacaatcct gcagcagctg cgcctaaagc agcggcgagc caagaggcgg 275461 ctgtgctgtg tgaaaaagca gcagctccct gataacatat gaaactaaat aaaatcagat 275521 aaagacattg aaaaagggta atcacgtact aaactcctca aaaatagtag ttttgaaaat 275581 aatcaagctg ctgcttagtg atcatcgctt ttttagacgt tccctcaaag gaaactgtga 275641 atgaatgctt ggtataagcg gaaaaatgct ttatgtaatg aatgttgata ataaaggaac 275701 gatgcgaacg aagaaaatct ttttcgggca ggtcgccttt aatatcattt aatgtttgat 275761 acgtttgcac ctcttcggcg gttgtcacaa tcgtcgtcga acgtcccgtc cgttctgcga 275821 aaataatatc cttcttttgc aggacgtgca tttcagactt ttgctttatc aatatacgcc 275881 cattcaaact cgtttccgtt ttctttttca agtaccggtc gaaggaagcg gccagacggt 275941 cggcatagta cggcttcata atataatcat ggacgttcag gtcaaaggcg tgaaccgcat 276001 aaccgccgtg gccggtaaca aaaatcacat ccacatcaag tgaatgggat ttgatcaaat 276061 cagcaagctc gtagccagac atatggggca tctcgatatc ggcaagcagc agatcaatgt 276121 ctccgttctt tacccgcctg taggcttcct tcgctgaatc ggtggaaaag acaatttcga 276181 cgtcctgcat tctggacacg atcgcttcta acttctctaa atctactcga taatcatcta 276241 caagtccgac ttttaccatt atcattcccc tagttacata gaatcatctt tattctatcc 276301 catttcacga cataaaaaga actcttcgcg acaactttat ccaactaatc cagcttttcg 276361 tatatagtca ttactagaaa taaagataag ggagattgtg acatgattac actgaccgat 276421 tgcagccgca ggtttcagga taagaaaaaa gtagtcaaag cggtgcgaga tgtaagctta 276481 acaattgaaa aaggagaagt cgtcggcatt ctcggagaaa acggtgccgg caaaacgacg 276541 atgctgagaa tgattgcttc cttgcttgaa ccatcacagg gtgtaatcac agtagacggc 276601 tttgacacgg tcaagcagcc ggctgaggtc aaacaaagaa tcggtgtctt attcggagga 276661 gaaaccgggc tttacgacag gatgaccgct aaagaaaatc tccaatactt cggcaggctg 276721 tatgggctga accgccacga gatcaaagca agaatagaag atttatcgaa acggttcggc 276781 atgcgcgatt atatgaaccg gagagtgggc gggttttcga aaggcatgag gcagaaagtc 276841 gccattgcca gagcgctgat tcacgatccg gacatcattt tatttgatga gccgacaact 276901 gggcttgata ttacgtcaag caacatcttc cgcgaattta tacagcagct gaaaagagaa 276961 caaaaaacga ttcttttctc cagccacatt atggaggaag tgcaggcgct ctgtgacagt 277021 gtcatcatga ttcacagcgg agaggtgatt taccgagggg cgcttgaatc actatacgag 277081 agcgagcgca gtgaggattt gaattacatc tttatgtcta agcttgtcag ggggatttct 277141 taaatgctga gccatattta taaaaaagaa atgatcgacg ctttacgcga cagaaaaacg 277201 atattactca caatcttagt gccgatgatt atgatgcttg gacttgtctt tttttatgaa 277261 agcatgctgt ccgacaaagg ggagcagtac acgctggctg tcggccattc gcttccgccc 277321 gcactggaaa gcaagcttaa tgagattgac gaaatcagcg taaaaacatt tgcaaagcct 277381 gaagaggcag ttgatgaagg aaaagcagat gcctatctga acgtcccgaa agagttcgac 277441 tcatatgtca acagcatgac accttttaag gttgatgttt acggcaattc aatcgatcaa 277501 gggtcgtcaa atgccatgca gcttgtgcag tctgccttag atcagtacaa aaatgaaatt 277561 gtgcagcaac gtttaacaaa taagcatatt gatcaatcgg tgatccagcc gtttacaatt 277621 cagcaaaagg aagcggatga ggagaaaggg acttccgcta ttatgctttc cgccattctg 277681 cccatgctga ttctgacttc cattgtttcc ggcgcaatgc cgatcgctct tgatatcatg 277741 gccggtgaaa aggaccgaaa gtcaatcgag gcgctgctat taacgccagt cagcagaaac 277801 aaagtgctgg tcggcaagtg gcttgcggtt tccacttttg gcgtggcttc aggtgtattt 277861 gctttggtgt ttttgatttt gtccaccgtg ttatttaccg aaaatttaaa aacggccttc 277921 cagctgggag atcatatgtg gagtgtaatc ggcgcttcag ccttaatcat tgtgctctct 277981 gcattgctga tatctgcgat ggagcttttc atcagcatca tgtccagctc ggtaaaagaa 278041 gcgcaaagtt atatgtctct cgtcgtcttt ctgcctgtgt tcccgatgtt tttcatcttc 278101 agcaaggcac cgaaccaatt tgacttatca tactttctca tcccgtttct gaacctgcat 278161 gcgttattta aacagctttt attcgggatg gttgacccgg ctaccatttt gtctacgtca 278221 ggaaccatcg ccgtgctcat cgccatcttc tttttactag ccagagcctg cttcctgaaa 278281 gacaaatggg ttcttccaaa ataaacttgc gaaaggagaa atacactttc tcctttttgt 278341 atatcctgaa aaaagaagga aaatagaaaa aggatatcta atacaaaaag tgaccctgca 278401 ctatttttca tcaaaattgg tttcaaagga gaaggaacaa tggatcaaac acgtacactc 278461 ggcaaaacga agctgaaggt gaagcggatc ggattcggcg cgaatgcggt cggcgggcat 278521 aatctatttc caaatctaaa tgatgaaaca gggaaggatt tagtgcgcac ggcattggat 278581 ggcggcgtca attttatcga taccgccttt atatatggat tggggcgatc tgaagaatta 278641 atcggcgaag tcgtacagga acgcggcgtg cggaatgagc tcatcatcgc caccaaagga 278701 gctcataaag aagtggacgg cagcattgaa ttagacaata gccgggagtt tcttcgcagc 278761 gaggtggaga agagcctgaa gcggctgaaa acagattaca ttgatttgta ttatgttcac 278821 tttccggatg gaaaaacacc tctcgctgaa gtggcgggca ctttgaaaga gctgaaggat 278881 gaggggaaaa tcaaagcgat cggcgcttcg aacctcgatt atcagcaatt gcaggatttt 278941 aatgctgacg gctatttgga ggtcttccag gccgaatatt ctctcataca gcgtgatgcc 279001 gagaaagagc ttcttccata ctgtgaaaaa caaggcatct cctttattcc ttactttccg 279061 cttgcgtccg gactgctgac aggaaaattc acgcaagaca cagtctttga tgatttcaga 279121 aaggataaac ctcaatttca gggtgaaacg tttatccaca atctcaaaaa agtagataag 279181 ctgaaagcag tagcggagga aaaacaagcg gatacggcac atgtcgcctt ggcgtggctg 279241 ttaacgagac cggcgattga tgccattatt ccaggagcta aacgaccgga gcaattacag 279301 gataacctga aaaccttgaa cattgaactg accgaagatg aagtgaattt catcagcgac 279361 attttcaaat aaaaaaggaa atagccgtca tggctatttc cttttggtgt tttattcttt 279421 gatgaatgct tcgactaatt ctgctgctct gtaatcatcc atatcaagct gccattggtc 279481 gatgtcattt ttcttcattt tcacttcaac tgttttttca gatgaagcag gtccaagctt 279541 tttgaattcc tcaggataga cttgaagcgc gtatttcact gcctcttcat agctggcact 279601 agagttttta ctgtagtagt ctttcacttt gtcttcgatg cggtctgaaa gagaagatgc 279661 atctacaggt ttaactgtgg cttcaacaat tgcttcgtct ttagagattg aagtcgtttt 279721 tgcttgaatg gaagagtttt tgcttaatcc ctctttaatg ccgttcacga tattatcaag 279781 cgctttgctg tccgcatatg tgctggaaag gccggaagct gagagataac cgtctttggc 279841 tgattcatta aaatcattta caatttcatt tttgttagcg ccggtgattt tttcgaaatc 279901 ggcgttatct ttgccgaaaa gaaggacatc aacataagct gataacgctt ttgcagaatc 279961 ttggagctta tctgccgtcg ccaggatttt tttgtctttt ccgtcaattt taaaagtaac 280021 tgattttggc tttttatcac cgtaagattc cggcgtatag ttaagctcgt attgcttgcc 280081 tttatctaca acgaagaaaa gatttccttc aacggatttg tcagcgttaa tcgtgctgcc 280141 ctgaagcttt tcgctatagt cttcagggtc tgtgtcagac attttggtat caccttgata 280201 caatgtgaaa tccatactgt ctacattcag cgggtctttt cctgtgtttt tcaccgcgac 280261 attgactttt aacacaagct ggtcatctga agtggactta tcatatttag acggaagtgt 280321 gtaagagaca tccttgattt tgacttgagc tatatctgag cttttttctg tttctgattc 280381 tttcttctcc gcgcttgttt tgctgccgga acaagcagct gtaaacatca tcagcagaag 280441 aattaggaaa acagcgtacg tttttttctg aaacattcat ttttcctcct caaatggttt 280501 aggaaagggg agtcttttgt ctttgagaaa tggatctttt tgaatggatt agcatcatat 280561 aaccaaaaaa atcagttctt ttctcacggt tttcaccgga ttttctggaa actccgccct 280621 cctttgtcat gaatggacct ataaaaagtt acaacggaat taattttaag attattagct 280681 tttatattga ataggttcat catcctattt ttggtgaaaa atgttctggt aaaactggta 280741 aactcagaaa actgtgtatt ttagactatt actttttgat tagttggagg gaacttaaga 280801 aggatgaaag gggccgcctt tgtgaagaaa gagggactga aacaaaaagc actggaaatc 280861 ggccgggtgc cgacacactt aaaactggaa attgaagatt atggcggtga tgataaaaga 280921 gctcattttt gttgggcaga tcctcaggat gagaataccg gcattatcgt ggagcttgga 280981 ccggacggag agctggaatc cctttcccgt gatattgagc ctgaaagcgg agaaaggctg 281041 tctgaggaga aactagagga tatcatgcgc caatttgtcg agactcatca tccgggggca 281101 ctctctgcct ttgttcgtga agaaaatgac cgtgcatacg gcgataaagt gagattttca 281161 tatgttcaaa tggaggctgg gcttcctctc cccatgagcg gatttatggc tgatgtttcc 281221 ttatcaggtg agattgttta cttccgttat tacggcgaag cgggcagcat catcaagcca 281281 aagcgggtcg cggatgttga agaggcactt gcctttatca agaaggacgt ggagttcgac 281341 cttttgtttg aggttctcca tcgttctgtt tacaaaaacg gagatgatca gccgcatttg 281401 gtgtacgagc ctgaaggtag ggcgattacc gtacctgcgg atttggttca agaagaacaa 281461 gcagttgatg atgacgatga ttacagggag ccggagagct ttcctctccc tttattcgag 281521 ggcatccgcg aaaaggccga tcctgacagc atgattggta ttgaaaatgg gtttgtcaaa 281581 gagcgggaag cggatttggg agatgggaga attggaatcg tttggcggaa tccggatgac 281641 cctgtgtatc agccggcgga taaaagcatg gacagctggt ttaagggacg gactcatcaa 281701 gtgctgaaaa ccatctataa caaagaaacc ggaaaactcg aaggcgtcat gtcatttatg 281761 gagaaaaaag ggccgctgac agtaaccttg gcagagtgtg aaaaaatcgc gcttcgcttt 281821 ctatttgctt tatttccgaa tgccgatcaa tattttagga tcagatacga cgaaaaagat 281881 gaagaagaaa acgcagtcgc tggttttacg tttgaagcgc attgtcacgg agttccgctc 281941 cgatttgggc agatcagaat ttgtgtcagc cgccagacag ggtatatcac cgtttatatg 282001 ggaccggata ttgacccaaa taagctggca accattgatc ctgtgccggc tatttcagtt 282061 gaacaagcca agtctatctt ttggcagcat tttaaagttg agcttggctg ggaaagagag 282121 tacggggatg atgaagaaca cagctaccgg ctcgtctata agccggtgta tccgcatttt 282181 atcgatgcac atacagggga gcctgtcttc agcatatggt gaaacagcca aaagtcacgc 282241 aattgcctca gatatagaag agagtatgtg atgaaagtaa cagaaagaat ctcaaaaaac 282301 aatgacaata atagaaaagg acctttcttc actttaaatg aagaaaggtc tttttatata 282361 ataaacagga ttctctttgt cgtagactct ttgaaaggga tgacttcatt ggttaataaa 282421 cagctgaaaa agaaggcgca ggagatcgga aatgtaccga cgcattatga gcttgagata 282481 gaagattacg accaaaagca aaagaagtac gggcaggcat attttatctg gaaggaccct 282541 aaagatccgg aaaagcacat tacagttgaa cttagaaatg acggcgcctt gctcaccttt 282601 tcaacaactg tccactccga gacagacaaa aaacttccag atgccgagct gaagctgacg 282661 gctcttcagt ttgccgctgc caatcatccc ggcacattta tgaattttca ttttcaaggc 282721 aaggaagaaa gggggcagca catccggttt gtctatacca aaatggagct ggggcttccg 282781 attcccaatt caggcttttt aattgatatg acacgaagcg gtcagattgt ccactttcta 282841 tattacgggg aagggcataa agccgaagtt ccgacggaat ttgtagcaaa agagaaggtt 282901 gtatcccatt acttaaacac aatgtctttt gagctgatgt acgatgtcat tgatggcgaa 282961 caggaaccaa ggcttgtata tgaaccgatt ctaccgggat acagctatcc cgcagatgta 283021 gacgaaattg tgcccgacca gcatatcgca gatgaaagaa tagaaaacac ggcgccactg 283081 ccgccgcttc agaacaagga agaagttgat atatttgcct tgctgggttt tacctctgat 283141 atgcagaaag tcagtgaaag agactttgga gaacaaattg gaagcacgtg gcgcaggggc 283201 gctgcgccgg agcgtaagga tttaagcata ggaagctatt ttgaaacgag aaataaaaat 283261 acaatcaaaa tgaagacgga taaaagaacc ggaaaattaa aagcagcgct ttcttttatg 283321 gactggcgga acaacctcca atgctccacg gaagaatgcc aagagatagc gcttcaattt 283381 ttgtatgccc tctatccgag agcggctgag tttttcaggg tgaatcccgt ccgaattgat 283441 gaaagaggga gagtccgcaa ccatttttct gtctggtata aaggagtgcc gctgcggttc 283501 ggcgctgccc gcatcattgt caatccggaa actgggttga ttgacgcttt tatggcgcct 283561 gatattgaac ctgaacaatt ggaagcgata aatcacaggc cggatgtttc cgctgaagaa 283621 gcgaaagaag catttttagc cgcttttgat gtgaaactgg aatggcagcc tgattttaca 283681 gcaggcagtg accagcactg caaacttgtc tataagccgg tttacccttc ctatattgat 283741 gcgcacataa ggaaaaagaa aaggctgtga ggggtgtcta gttaggaatc atctccaagt 283801 gggggtagtc cttgaatcgt ttccaatccc cgccccattc gaaaccgagt gtcttagcga 283861 tctcgacaac ctccagccaa tctgattttc cgttttgatt gccgtcatat tccatatccc 283921 atatgatgct gccatccttt ttttgaaggg cgaaatcaat cgctaaacca tagttatgat 283981 acgattcccc tcctcttgca taggtgacaa tattcccttt ttttgtacgt ccctgtttat 284041 ataattcatc ttgttcctta aaggacctga atccttcagt aatgacgacg tcaatgcctt 284101 tattcgctgc agcggctttg agtgcatcgg cattctgctt cacaatcgga tgaagatccg 284161 aggggacagg catgtcctgc aaggcgtttt gagaatgcca ttcatgccga atataactaa 284221 aacaaagatc tagaagaaat agaatacata agataacaaa tgtttttgcg ggtaagttca 284281 tatcggtctc actttctcaa gatgtgctga atgttaacgc ttttaagtga ttgactctct 284341 ctaaaagcga acagctatga taaaatataa cataaatagt agcaggagga aggaggcaga 284401 ccgatgagag caaagattcc atcagaagaa gtagcagtaa agctgaatga atggtacaag 284461 ctcattcgcg catttgaagc agatcaagca gaagcgttaa agcaggagat tgaatatgat 284521 ttagaagata tggaagagaa tcaggacttg cttttatatt tttctttgat ggaattccgg 284581 catcgaatca tgcttgataa gctgatgccg gtgaaagaca gcgataccaa gcctccgttc 284641 tctgatatgc tgaacgaaat tgaaagcaat cagcaaaaac tcacgggctt actggaatac 284701 tacttttatt atttcagagg aatgtacgaa ttcaagcaga aaaatttcat attagcgatt 284761 gaccattata aacatgccga ggaaaagctc gagtatgtcg aggatgagat cgaaaaagct 284821 gagtttcttt ttaaagtcgc agaagtgtat tatcacatca aacaaacgta tttttccatg 284881 aattatgcga gccaggcgct tgatatctat acgaaatatg aactgtacgg tcgccgccgg 284941 gttcagtgtg aatttatcat cgccggaaat ttgaccgatg tgtatcatca tgaaaaagca 285001 ctgacccact tgtgcagcgc tttagaacat gccaggcagc ttgaagaagc gtacatgatc 285061 gctgctgcct attataatgt cggacactgt aagtacagtc tgggtgatta caaagaagcg 285121 gagggctatt tcaaaacagc cgccgccatt tttgaggagc acaactttca gcaagctgtt 285181 caagctgtat tttcactgac ccatatctac tgtaaagagg gaaaatacga caaggcagta 285241 gaggcttatg accgcgggat aaagagcgcg gctgaatggg aggatgacat gtacttgacg 285301 aaattccgcc tcattcatga gctgtatctt ggaagcggcg acctgaacgt gcttacagaa 285361 tgctttgacc tgctggaatc caggcagctt cttgctgacg ccgaagatct gctgcatgat 285421 acagcggaac gtttcaatca gttggaacat tacgagtccg ccgctttctt ttaccgcagg 285481 ctgatgaata ttaaaaagaa gcttgccgag cagcgttttc aataggaaat ggcagagaac 285541 tacaggttct ctgctttttt tgtgctgttt tcaactcgga aaaacagggt attttccact 285601 gcatagtgag aaacagagga ggatatcaag tatgtacaaa gatttaaccg gaaaaacagc 285661 gattgtgaca gggtcttcaa aaggaatcgg gaaagccatt gcggaacggt tcggaaagga 285721 gaaaatgaat gttgttgtaa attaccacag cgacccgtct ggagcagatg aaactctgga 285781 aatcattaag cagaacggag ggaaagccgt ctcagttgag gcggacgtgt caaaagaaga 285841 ggggattcag gcgctcttgg acacagcttt agagcatttc ggcacgctcg atgtgatggt 285901 aaacaactcc ggttttaacg gcgttgaggc gatgccgcat gagatgagtc ttgaagattg 285961 gcagagagtg attgatgtca atgttaccgg aacctttctg ggagcgaaag cagcacttaa 286021 ccacatgatg aaaaacaata tcaagggcaa tgtgctgaat atctcaagtg ttcatcagca 286081 gattccgcgc cctgtaaacg ttcagtattc cacatccaaa ggcggcatca agatgatgac 286141 ggaaacgctg gcgctcaatt atgcggataa gggaatccgc gtcaatgcga tagcgcccgg 286201 caccattgcc acagaatcaa atgttgatac gaaaaaggaa gagagcaggc aaaaacaatt 286261 gaaaaaaatc ccgatgaaag ccttcggaaa gcctgaagaa gtggcggcag cagcagcttg 286321 gctcgtatct gaggaagcaa gctatgtgac cggcgcaaca cttttcgtcg acggcggaat 286381 gacactttat ccatctcagc ttgaatagaa gacaaaacag ggggattgcg ggatgaaaac 286441 agactggtgg aaggatgcag tggtgtacca aatttacccg agaagctttc aggacagcaa 286501 tggagacgga attggggact tgcgggggat tatttcccgt cttgactaca taaaggagct 286561 cggggcagat gtgatttgga tttgcccgat ctatccttct ccgaatgttg attacggcta 286621 tgatgtgaca aaccataagg cgattatgga ttcttacgga acaatggacg attttcacga 286681 gctgctggac caggtgcatc agcggggatt aaagctggtg atggactttg tgttaaatca 286741 cacctcggtc gagcatccgt ggtttaaaga agcggagctg gacaaaaaca gcaaataccg 286801 tagctattat tattggcgtc ccggcacaaa gaacggcccg ccgacggact ggctctcaaa 286861 ctatggatgc ccggtctggc aatacgaaga gcacaccgga gaatactatc tccatatgaa 286921 tgccgtcaaa caagctgatt taaactggga aaatcccgaa gttcgccagg cggtgtatga 286981 catgatgaaa ttttggctcg ataaaggggt cgacggtttg cgaattgatc agctccatct 287041 catttctaag aaagaatatc ttccttcgta tgaggactat atcaatcagc aggcagagcc 287101 gaagcccttt cagccaaatg gcgaacgaat ccatgactat ttaaaagaaa tcacagatga 287161 agtgttttct cattatgatg tcatgtctgt cggagaggtc ggcagtgtca caccggaaga 287221 aggcctgaaa tatacgggaa cagataagca tgagctgaat atgatttttc actttcagca 287281 tatggagctt gatcagcagc ccggaaaaga acattgggat ttgaagcccc ttgagctttc 287341 tgatttaaaa tcggttttga caaaatggca aaagaagctt gaacatcaag gctggaatac 287401 attgttttgg tgcaaccacg accagccccg gattgtgtcc agattcggag acgatgggga 287461 ataccgcaaa gcatcagcga aaatgctggc agccgtaatt tattttatga agggcacgcc 287521 gtatatttat cagggagaag aaatcgggat gacaaacgcg ccgttcaccc ggattgaaga 287581 ctacaaagat atccaaacga tcaatatgta tcataaacgg gtgtttgaaa aaggctatga 287641 tccaaatgat gtgatgagat cgatcttagc caaaagccgg gatcacgccc ggaccccgat 287701 gcagtggaac agcggcaaaa atgccggatt tactgacggc acgccttggc tgaaggtcaa 287761 tccgaacttc accgcaatca atgtggagga agcgcaggga gatcctgatt ctgtcttaaa 287821 ctattacaaa aagctgatca gcctgagaaa gcagtacgct gacctcatga aagggagctt 287881 tgatcttttg cttccggacg atccgcagtt gtttgtatac atgagagaaa acagtaaaca 287941 acagcttttg tcggtcaata atttttcaaa agagcaggct gtttttcagt ggcctaagaa 288001 ctgcggcaaa gctcaggcct cactgcttct cagcaattat aacaacgatg atcttgatga 288061 cgaaatggtg ttccggcctt atgagagcag ggtctatctt ctggacaaaa caaactaatg 288121 attgaagtag cccggcattt ttagccgggt ttttttagta catatattcg ctctgcaggc 288181 gggaagaata aatgaaaatg aaatttattc ttgcaaaacg taatgacttc ggtttattat 288241 gatataggat tacaaaatcg ttatcatttt gatttaaagt tactgaaaaa gaggggatat 288301 acgatatgtt taaaaaatgg agcggtttgt ttgtgattgc agcgtgcttt ttattagttg 288361 cagcatgcgg caactcatca acaaaagggt cggcggattc aaagggtgat aaactgcacg 288421 ttgtcacaac gttctacccg atgtatgaat tcacaaaaca aattgtaaaa gacaaaggcg 288481 atgtggatct gttaatccca tcttccgttg aaccgcatga ttgggaaccg acgccgaaag 288541 acattgccaa cattcaggat gctgatttgt tcgtttataa tagtgaatac atggagacat 288601 gggttccgtc agctgaaaaa agcatgggcc aaggccatgc cgttttcgtt aatgcaagca 288661 aaggcattga tttaatggaa ggctctgaag aagaacacga agagcatgat catggggagc 288721 atgagcacag tcatgcaatg gaccctcacg tatggcttag ccctgttctg gcacagaagg 288781 aagttaaaaa tattacggct caaatcgtga agcaggaccc ggataacaaa gaatactatg 288841 agaaaaatag taaagaatat attgcaaaac tgcaggatct tgataaacta tatcgtacaa 288901 ccgcaaaaaa agcggagaaa aaagaattta tcacgcagca tacagctttt ggctatctgg 288961 caaaagaata cggcttgaag caggttccga ttgcagggct ttcacctgac caagaaccga 289021 gcgcagccag cttggcaaag ctgaaaacat atgccaaaga acataatgta aaagttattt 289081 actttgaaga aattgcatcc tcaaaggtcg cagatacgct cgccagtgaa atcggcgcga 289141 agacagaagt gctgaataca ctggaaggct tgagcaaaga agaacaggat aaaggtttag 289201 ggtatatcga cattatgaaa caaaacctcg atgccctgaa agattcacta ttggttaaat 289261 cataagatag tgtgcgccgg aggggtgcac actatttctt tgtgagaaag gaagattaac 289321 atgaatctcg tctcattgaa agatatcgtt ttcggctatt cccatacgcc tgttttagat 289381 aaagtatcac ttgatattga aagcggtgag ttcgtcggca tcactggacc aaacggcgcc 289441 tctaaatcga cgctcataaa ggtaatgctc ggcatgctga aaccgtggga aggcacagtg 289501 acgatcagta aaaggaatac agaagggaaa cgcctgacca tagggtacgt cccgcagcaa 289561 atttcttcat ttaatgccgg atttccgagc acggtgctgg agcttgttca gtcaggccgc 289621 tatacaaaag ggaaatggtt taaacgttta aatgaagaag atcatcttga agtagaaaaa 289681 gcattgaaaa tggtggaaat gtgggacctc cgccatcgta aaatcggtga tttatcaggc 289741 ggacagaaac agaaaatctg tatcgccaga atgctcgcca gcaacccgga tctgctgatg 289801 ctggacgaac cgacgacagc tgttgattac gacagcagaa aaggatttta cgaatttatg 289861 catcatctcg tgaaaaatca caaccgcaca gttgtgatgg ttactcacga acaaaacgaa 289921 gtacagcaat ttttagataa agtgattcga ttagagagag gagaaaaagg cggatggaaa 289981 tgtttgactt ggaattcatg cgacgagctt ttctagcagg cggcatgatc gccgtcatgg 290041 ctccgatact aggagtgtat ctcgttctca gaagacaggc cttaatggct gacacacttt 290101 cacatatctc attgtcaggt gttgccatcg gcttttttct cagcaccaat ataaccgcag 290161 caagcatagt cgtcgtgacc atcggcgcga tcggaattga atacatgcgg cgggcgtatc 290221 ggacttattc agaagtgtcc attgccatct taatggcagc tggtttgtcc ttcgcgatgt 290281 ttttaatcag cctttccaaa ggcacagcca atatgagcat cgatcaatac ctatttggat 290341 cgcttgtgac agtaaaccag cagcaggtct atattatcag tattatcaca ctgctgatcc 290401 tgctttattt tattgtactg agaaggccgc tctacctgct gacgtttgat gaagctacag 290461 ccaaaacatc gggaatcaat acaaacgttc tctcgttgtc attcagtatt gtcacaggcc 290521 ttgcgatttc agtcattatt ccgatcatcg gggtccttct tgtatcggcc ctgctcgtat 290581 tgccggcagc cttcgccatc agaattgcaa aaggctttaa catggttttc attacagcca 290641 tactcatttc attattcagc gtatttacgg gactgacatc atcctatcag ctcgggacgc 290701 cgccaggtcc gtctattacc ctgctattga tcgttttgct attaatcgga tttgcagttc 290761 agggagtttg gacgtttatc aaaaaagaag ctcagcgcaa aaaaagaagc cgataacatg 290821 aaaagcagtt ttccctaggg aaaactgctt tttttataga aacaattcgg caaggcgctc 290881 ataagattct tttttcgcct caaaatcaaa cacattgcac agaaccatga tttcatttgt 290941 ttcgtagcag cctgtgaggt ctaacagctg ttgtttgaca gtggtgggag aaccgatcac 291001 catccgcttt ctgttttctt ctatgagttt tttatcggac gctgtatagg gatgagcttt 291061 cgcttcctcg atgcttggca cgcggctgtc caagcctttt ccgacgcgaa gaagccacag 291121 atcctggctt aatgcgagtt cttctgcctc ttcatctgtt tttgcgcaaa tgacaaaaat 291181 cgtaaacagt gcggatggat tcgaaaaatg ggctgagggc cgaaagcttt cccggtagat 291241 gcggaatgca ttttctcctc gctcgggatt aatgaaatgc ccaaatacat atccaatccc 291301 ctggtgcgcc gcgcgtcttg cgctgttttc accaagaccg agcacccata gctcgggtgc 291361 cgtaccaata aggggcgccg ctttgattcc ggcatacgga tggtcgggag gaagggaatc 291421 tgttagaaaa taagagacat cctgcagctg tctgttaaat tcggttaagc tttttttcac 291481 cccgtccgtt aatgcaagtc tggtttttgt cgtgccgccg ggggagcgac cgacgccgag 291541 gtcaatccgg tttggataca gggcctcaag ctggcgaaag gtttcagcca ctttaaatgg 291601 gctgtattgg ggcagaagca cgccgcctga tccgacacga atggtgtttg tctgtgctgc 291661 gatgcgggcg atcatgattt caggcgctgt gcttgccagt cctttcgtgc tgtgatgctc 291721 ggcaaaccaa taacgcttat agccccactg ttcgcttaat tgggcaagct caaccgaatg 291781 ctggagagtt gtcacagggc tttctccttt agaaacaggt gcctgatcaa gtatgcttaa 291841 atgaatcaaa aggccgcttc ctttctgtct gtttttagat ggtgacacca gaataggcaa 291901 aatgacttgc ccgcgtcaaa tggtttgttt aagaagcgca ctttatagca tttgcaaatc 291961 atatatcaaa tatggaagtt ttttttcgag gtttttcgtc aattattctt aacttttacg 292021 aaactttgat ataataacaa acgtatatat tagtaattta cggcttattt tccttgtgag 292081 cgtaaaaata aatgtgacta tcttcacatt ttgatgagta ggagtgaatc gtgtggcaat 292141 ttctttagaa aaaggtcaac gaattgattt aacaaaagga aaagccggtc tgtcaaaatt 292201 gatggtcggt ctcggctggg acccagtgtc ctcaggcgga ggattcttca gcaaactgct 292261 tggcggaggc ggtccgaata tcgactgtga cgcttcagtg ctgatgctgg aaaacggaaa 292321 attcaccgat aagaaaaacc tgatttattt cggcaacctg aaaagccgct gcggcggtgt 292381 acagcataca ggcgacaacc tgacgggtga cggtgcgggc gatgacgagc aaattatgat 292441 agatttagat aaagtgcctg gaaacatcga taagcttgta tttgtagtga acatttacga 292501 ttgtgtcaga agaaaacaag atttcggcat gattcaaaat gcgtttatcc gcgtagttga 292561 tcaatctaat cacgaggaaa tgctcaagta caatttgaga gacaattacg ccggcagaac 292621 aagcctgatt acagcagaaa tctaccgcag cggcagtgag tggaagtttg cggcggtcgg 292681 tgaaggcaca aacgatacga gattagaaga tattatcagt cgatacgtat aaaagaaaag 292741 gagtggatga aacatgacaa tttcattggc aaaaggacaa aaagtagatt taacaaaaac 292801 aaatccgggt ctttcaaagg ttgttgtcgg tttaggctgg gatacgaaca agtatgacgg 292861 cgggcacgac tttgatcttg actcaagtgt gtttctgtta gacgccgcgg gcaaatgcgc 292921 gtcaccaaac gactttattt tctacaacca gcttgaaggc ggcaacggtt cagtcgttca 292981 ttcaggcgac aacctgactg gtgctggcga aggcgacgat gagaatgtaa aagtaaatct 293041 cagcgctgta ccggcaaaca ttgataaaat ctcatttgtt attaccattc acgatgcaga 293101 agcgcgcagc caaaactttg gacaagtatc aaacgcgttt gtccgcatcg taaatgaaga 293161 aacaaatgaa gagctcatcc gttacgatct tgcagaagat ttctctattg aaacggcaat 293221 cattgcaggg gagctttaca gacataacgg cgagtggaaa ttctcagcaa tcggctcagg 293281 ctaccaaggc ggccttgccc gcattgcaac agactacggt ttgcaagtcg gttaagacaa 293341 atacgaagag cagaaaggag agaggcagta tggccattca attatcaaaa ggacagcgca 293401 ttgatttaac aaaaacaaat ccgggactga ctaaagcggt gatcggctta ggctgggata 293461 caaacaagta ctccggcgga cacgattttg acctggatgc ttcggccttt ttagttgatg 293521 cgcatgataa ctgcgtaaat gatctcgatt tcgtcttcta taataacctt gaacatccga 293581 gcggcggtgt catccatacg ggtgacaacc gcacgggtga gggcgacgga gatgatgagc 293641 agattatcgt tgatttctca aaaatccctg ctcacattga gaaaatcggc atcacagtga 293701 ccattcacga cgctgaagca cgcagccaaa actttggaca agtttccaat gcatttgtcc 293761 gcgttgtgga tgaagaaacg cagaatgagc ttcttcgctt cgatttggga gaagacttct 293821 ccattgaaac agctgttgtc gtttgtgagc tttacagaca cggcggcgag tggaaattca 293881 atgcaatcgg cagcggattt tccggcgggc tggctgcatt gtgccggaat tacggtttgc 293941 aagtgtaagc gagtgacaaa tagagaagtc accgtttcaa attataggag gaaaaaactt 294001 ggacttttta catcatattt tgtctacgta tgcttcattt ttcgattgga aaatgtgggg 294061 ggaagttctg actgatcctg tttcctgggg tttgatcggt tcccttgttg ttctggaagg 294121 ccttttatcg gccgataacg cgcttgttct tgcggtcatg gttaaacacc tgccggaaaa 294181 acagcggaaa aaagcgttaa cgtatggttt gtttggagct tatattttca ggtttatttt 294241 catcgggctc ggtatgcttc tcattaaatt ctggtggatc aaggtgcttg gcgcgcttta 294301 cctggcttgg ctcgtcatta agcacttctg gataggcgaa aaagaagagg aagcggacgg 294361 catgaagaaa aactcttgga tggtccgcac gttcgggatc ttctgggcga ctgtcatttc 294421 agtagaatta atggatcttg ccttctctgt ggacagcatc ctggccgcgt ttgcagtatc 294481 tgaaaaagta tgggtgcttc tgattggcgg tatgcttggt attttaatga tgcgtacagt 294541 ggcaaaagtg ttccttgtgc tgattgataa aattcctgag ctggaaaaca cagcattcgt 294601 cttaatcggc attatcgcgc tgaaaatggc ggggagcgct ttccattacg aaatgccgca 294661 ctctgtattc ttcattatca ttatcgctgc atttgcggta acattgatca ttcactacat 294721 caataaacaa aagcaggtgc gcgaacaaac agccgcttca aaagaagaat aaaacaaaac 294781 aaggagggag gttcaatgtc cttccttttt tgttaccgaa atatcgtttc aatgacaaac 294841 cggaaaggag gatatgatga gacaagaaga actaaccatt cataaagcac ttccggctga 294901 tggcgattgg aaaagcctgc tgtttcagcc attgccggag cgggatcact atgaaactgc 294961 acaaggcctt tctttttctc gtcttgccgg tcagatattg ggcacgccta ttgatgagac 295021 ggactactat aacgagctgt atgagctgtc tgtaaacgac cgcataacga ttttgagtga 295081 aacgcttgat aaaacaatcg aaccggaaac atttcaaaag cttcagcata ttcattccat 295141 caatcagaaa gaaaaagggc tgtcagtcag ccgctttgtt gcctttctgg acggggaaaa 295201 gctgattgcg aagcactcaa atcccttgat gcaccgccat ttaagaaaag cgttgatgac 295261 gcttttacat acctttgcgg acagtcatga aaaggggctg aatcatcctg attttcgcag 295321 agtgctgctt gatgtctcga agttttcctt aaaccatctg aacccttggc tggaaaaaac 295381 cgatatagag cgggagatgc cgaaggttgt ttggtatgga gatgcgacga aaagccagct 295441 ctatttctta tattatctga tgctggtcgg ctgtgatgta ctgctgttcc atccggcggg 295501 aacggatcag ctggcgcttg tcgacccgaa gcaggagctc ggttttacgg aaaagctccc 295561 ggatgtttcg gagcttcagc cgtttccgaa agaaaaacca gaccggaaat caacagtggc 295621 ttaccgctca acaaaggaaa ttgaacatgt gctgaatcac gaggaatcca tgctatataa 295681 gccgtggcag ttcagagatc acacaccggt gtccgttacg ctgaaaacga cctatgatga 295741 attgttttta atcacgaaag aacgcgcctt tattcggccg aatttcaaag ctgataaaca 295801 ttccattgag attccgaatg tattcgccaa aattatgggc gtgtcgaaag acaataagga 295861 atattggaac aggcttcata ctctagcgga ttatcaggaa acagaaatgg tcagaagctt 295921 tccatttaca gaagaaataa agtcgaacta tcaatttcac tacagccacg cacttgatca 295981 agaagggaac attgatccgg acaagctgat ggcaagcaat gtgtggcagt acaaacagct 296041 gccggcgggc gttcagactg ccattgccaa aacgatttcg agaatgtgca ggtacccgcg 296101 gcttaaagcc ttgcatcagg aacaagtcaa ggatgttcaa atctatttgt ttaaacaaac 296161 aacaaacctg cctgctaatc tgctgaaatt gattcaaatg ttcgactatg cgcaaaccgt 296221 tccgaaactc gttttatatc atacggaaat gagcggcgga ctcacgcgtt cggatgctgc 296281 cgccctgctg ttcctgaatg aaatcggaat cgatatcatc atttataatc cgcccggaca 296341 ccaagatatt gagcagttta ttgaagagga tcagtatgat atccactggc tggatgacat 296401 ggtgtttcag caggactaca aagagccttc gcttgtgaaa aggctcttca gaaccattac 296461 ccaaaaataa ggagagaaga aaagcatgac aacagaaaat caaaatccgc ttgttctcga 296521 taaaaatgaa gagatttccc agcaaaaagc tgacgatatc cgtcttcagc tccgtcagga 296581 accagaagtg aagcggcttg ctcaacaaat tgacgtcaaa aaccaaatgg agctgcttga 296641 gtacggcaag gagccggccg ttgaaatatc caagttctct gaccgcatct tggggatgat 296701 gaaaacaaca agcgtgacag actccggcac aatgctgact cagcttggga aaatcatgga 296761 ccgcttcgac aaaaatgatt ttgatgagcc aaagggatta atggcgaaaa ttttcaaacg 296821 cggcggcagc atgattgaaa aaatctttaa aaagtatcag acgcttggcg gagagattga 296881 aaaaatccac gttgagattt caaaatacaa agatgagatg acgaagacga actacacgct 296941 cgatgaaatg tatgaaaaca atatcaaata ctatatggag cttgaaaaat acgtcgttgc 297001 cgggcagatg aaactggaag agatgcagtc gatccttcct tcatatgagg aaaaagcggc 297061 aagcgggaac cagctggcgc aaatgcagct cgatacgttg cgcaacggca ttcaggcgct 297121 tgaggaacgg gtgtatgatc ttgacatggc acggatggtg gcgcttcaaa ccgcacctca 297181 aatccgtctc ctgcagcgag gaaatgcaaa gctgatcggg aaaatcaact ccgcgtttat 297241 cattaccatt ccgattttca aaaacggcat tattcaggct gttacggtaa agcggcaaaa 297301 gcttgtggct gattccatga gcgagcttga ccgccggaca aacgagatgc tgaaacgaaa 297361 tgctgaaaac atctcgagcc aaagtgttga aattgcgaga atggccggca gaccgagcat 297421 agatattgaa acgattgaat cgtcttggaa cacgattgtc agcggcatgc aggaaacaaa 297481 acaaatcgaa gaagaaaaca agcgcctccg cgaagacggc gcgagacgaa ttgcccagct 297541 tcaggataat attaaaaaag cagcattgca gcaataataa aaaccccgct tgtggaacat 297601 aagcggggta tttcaattac atcatttagt taatgacaat gtgtaaagac aggtgtaaac 297661 ttaaacggta atcattttgc atatcagagg tgttggcaat gggaaaacaa cagcctatat 297721 cccagcgtaa actgctgggc gtcgccggtt tggggtggct gtttgatgca atggatgtcg 297781 gaatattatc gtttattatc gccgcgctcc atgtagagtg gaatctgtcg cccgaagaaa 297841 tgaaatggat cggaagcgtc aattccatcg gcatggctgc gggtgcgttt ttgtttggtt 297901 tgcttgctga tcgaatcggc cgcaaaaaag tgttcatcat caccctttta tgcttttcca 297961 tcggaagcgg catttccgct tttgtgacga gcttatcggc atttctaatc cttcgtttcg 298021 tgattggtat gggacttggc ggcgagcttc cagtcgcttc aacactcgtt tcggaagcgg 298081 ttgtgcctga aaagcggggc agagtgattg tgcttttgga aagcttttgg gccgtgggct 298141 ggctcgcagc ggccttgatt tcttactttg tgataccaag cttcggctgg caggctgccc 298201 ttctgttaac tgcgctgact gctttttatg cgctgtacct gcggacgagt ctacctgatt 298261 cgccgaaata tgaatcgctt tctgccaaaa agaggtcgat gtgggagaat gtaaaaagcg 298321 tctgggcaag acagtatata cggccgacgg tgatgctgtc gatcgtttgg ttctgtgtgg 298381 tgttttctta ttacggcatg ttcctatggc tcccgagtgt catgctgctg aaaggcttca 298441 gcatgattca aagctttgaa tatgtcctgc tgatgacgct tgctcagcta cctggctatt 298501 tctctgccgc atggctgatt gaaaaagcgg gccggaagtg gatactcgtc gtttacttga 298561 ttggcacagc aggaagcgcc tatttcttcg gaacggcgga ttccttaagt cttctgctta 298621 cggctggagt gctgttatcg tttttcaatc tcggtgcgtg gggcgtgctg tatgcttata 298681 ccccggagca atacccgact gcgattcgag caacaggttc aggaacgaca gcagcgtttg 298741 gaagaatcgg cggcatcttc gggcctttgc tcgtcggaac cctggcagcc cgtcatattt 298801 cgttttcggt catcttttca atcttttgca ttgcaatctt acttgcggtt gcttgtattt 298861 tgattatggg gaaagaaacg aaacaaactg agctagaata ggaaaagcac ctcttaaaag 298921 aggtgctttc agcgtgtcga caaaccctcg cattcgttgt caggactgcg cttcggtgct 298981 caatgcgaag tggatcaacg gctaaattct caggcgtcct gcctaaacgc cgtcgtcatc 299041 acatcctgtg aatgtccgct cctatgctcg tccttcctag acttcaaggg ttttcaatca 299101 cgctgaaaag attttgtcaa caatctgagg cacctcttga atgaggtgct tttttacaat 299161 tgcgcccggg ctgtggattg gcgtttcccg gttttactga ttgtctggta gagcgtcata 299221 gaaagtatga acagaatggc agtaaatcct gtgacagctc cgaaatgctg tgtgctttga 299281 tataaaaaac ctgcaatact tgtaccgaca gtggttccgg catacatagc ggcattggaa 299341 agggaagcga tggttcctcg cgcatttggt gcaatggatt gaaagacacc catcattaac 299401 ggaaagatga tgccagctgt aaagaacgtg agaaaaaagc cggcttctac taaaaacaag 299461 tttggaaaga acggaagagc gaaatagaga gcgcccatta gcagcatccc gctgatcagt 299521 gttttaaaca tgcccagctt ttctgaaacc cggctgccga taaggctccc gagcatattt 299581 cccagtccga gtacaagcat agctgcgcca atttgtgaca cggttaaatg ataatccgcg 299641 gaaagccaag tacccagaaa gctgaacgat gcgaagtttc cggtttgaaa cagaaaatag 299701 gcaagcagaa tgaccgatgt tttcggcaat gaaaaaagct cccgataggg gttgacaatt 299761 gatgggcgcg ccaatggttc agaaggccgg atgccaggca tgaccgccgc caggatcaat 299821 agaagaataa gcgagcacgc tgacaaaacg aaaaatggcg tatgccatgt aaaggaagcg 299881 agaaaccctc caataggaag tccgagcatt tgtgaagcgg ccaaacctgc tgtcgcaatc 299941 cccatgcctt ttatgatctg agaaggctgg acaatgactg ggatggacgc ccaaatttga 300001 ggcgtcacaa acgcagcgct aacgcctgcg gcaaaacgga acaggcacat ggcggcaaaa 300061 gagggagcga tgccgcataa aaatgtggat acgataaagc ctgcaagtcc ccacagcatg 300121 actgttttcc tgttcagccg gtctgagatt gggcctgcaa tgaaagcgaa gagtgcataa 300181 ccgagtgcat aagcactgac catccagcct gacaaatcag tagagacatg aaactgatcc 300241 tgtaaaaggg ggagaagcgg cgaaagcaaa aaggtatccg tgccaatgac aaacatgaca 300301 ctgaagaaaa gccaaatgcg attcaaattt tatcactcct attgttttat aactttaaaa 300361 ctatgaaaca gatatgtata gagaaaaccc tttgttagag ggtttccaaa aagccaggca 300421 ggtatgtttg aaatgtgtct tcacgcagac tgacgtattt tgtccgcgaa tctttccggg 300481 ttgccgtcaa tcccgcttca cgcagcgttt taaaatgata agatgccgtg gttttgacaa 300541 tattgcactt ttcacctact tcaccgcagc tgagttcttt tccgctgaca taaagcgtac 300601 gaataatggc aagccttgat tcatcagaca gtgctttaaa aatttgcgct ctgatttgat 300661 catctgattg tttcatagtc atgaaactat aatacataat gggtgttgaa aaagcaactt 300721 atttttccag taaaggagca ggaagtcata agaggaagga ggaattcaat tccaataaaa 300781 gcgttttcaa ctaaaggtag gagaaaaatc acccgtaaaa tacaatcata taggaggatt 300841 acagagcatt tagaagcata aataagatca tgtggtcaca tggatgttta taaagaaatg 300901 gtacagaata aaagagaata tgctgtttgt gtgggaagtt acataaatgt tacggtaata 300961 aagattgctt aatatggagg gaaaatatga gtgtagatga gaaaccaatt aagataaaag 301021 tcgagaaagt ctctaagatt tttgggaaac aaacaaagaa ggcagttcaa atgcttgcca 301081 acggaaagac aaaaaaagag atcctgaaag caaccggatc aaccgttggg gttaatcagg 301141 cagattttga agtatatgat ggtgagatat ttgtcatcat gggtctatca gggagcggta 301201 aatcaacttt agtacggatg ttaaaccggc ttattgaacc gactgccgga aatatttaca 301261 ttgatggtga catgataaca aatatgtcaa aagaccagct ccgggaagtc cgccggaaaa 301321 aaatcagcat ggtcttccaa aagttcgctc tgtttccgca cagaacgata cttgaaaaca 301381 cagaatacgg actggagctt caaggtgtag acaaacaaga gcggcagcaa aaagcgcttg 301441 agtctcttaa gctcgttgga ctggaaggat ttgaacacca atatcccgac cagctttccg 301501 gcgggatgca gcagcgtgtc ggccttgccc gcgcgttgac gaatgacccg gacatccttc 301561 tgatggacga agcgttcagt gcgctcgatc cactgattcg taaagatatg caggatgagc 301621 ttcttgatct tcacgataat gtcggaaaaa caattatctt tattacgcat gacttggacg 301681 aagcgttgcg gatcggcgac agaattgtcc taatgaagga cggcaacatc gttcaaatcg 301741 gcacgcctga agaaatcctg atgaatccat ctaacgaata tgttgagaaa ttcgtcgaag 301801 atgttgattt gtctaaagtc ctcacagcag gccacattat gaaacgcgct gaaacagtgc 301861 ggattgataa agggcctcgc gtagcattga cactgatgaa aaaccttgga atttcttcaa 301921 tttatgcagt ggataaacaa aagaaattat taggtgttat ctatgcgtct gatgcgaaaa 301981 aagcggctga gtctgatttg tcacttcaag acatcttgaa tacagaattt acgactgtac 302041 cagagaatac gtatctgact gagatttttg acgttgtgtc cgatgcgaat attccaattg 302101 cggttgtgga tgagaagcaa agaatgaaag gaattgtcgt aagaggcgcg ctgattggcg 302161 cacttgccgg caataacgag tatatcaatg ctgaaggcac taacgaacaa acacaagatc 302221 cttctgcaca ggaggtgaaa taagatggat agactgccta gaataccttt agcagatatt 302281 attgaccgtt ttgttgactg gattacgatg acgtttggcg gattcttcga cggaatcgct 302341 aacggattgg ccgcttttgt aaatggaatt gtcaccggtc ttggatttat tccatctatt 302401 ttgttaacga ttattttcgc cgcacttgcg tggtggatca gtacaagggg aattgcgtta 302461 tttacgttga ttggattcct cctgatcgat tatttaggat attgggaccc aatgctgcaa 302521 acattggcgc ttgttttgac atctgtgatt atttcgattg tggtcggggt tccgatcgga 302581 atttgggcgt ctcagaaaga aacggttcgc cgtattgtaa cgccaattct tgatttaatg 302641 cagacaatgc ctgctttcgt atatctattg ccggcgattt tcttctttaa catcggtgtt 302701 gtgccgggtg ttgttgcatc tgttatcttc gcgatgccgc cgacaatccg catgactgtt 302761 ctcggtatta aacaagtgcc ggcggatttg attgaagcga ctgaggcatt cggttctaca 302821 acagctcagc gtttgtttaa agttcagctc ccgcttgcga caaaaacgat tttggccggg 302881 atcaaccaga gcatcatgct tgcgttatca atggttgtta tcgccgcaat ggtcggtgca 302941 ccgggacttg gttctgaagt atacagtgcc gttacacagc tgaaaaccgg ggtcggagta 303001 gaggccggta tcgccatcgt tatcgttgcc attaccctgg accgtattac tcaaaatatt 303061 aaagtgaaga agaaaagcag ggggaatgcc tgatgcttaa aaaaatcata ggcatcggcg 303121 tttccgccat gctggcgctc tcacttgcgg cttgcggttc agaaaacgat gaaaatgcat 303181 ccgcagcaga acaagtgaat aagaccatca tcgggattga ccccggttca gggattatgt 303241 ccctgactga caaagcgatg aaggattatg acctgaatga ctggacattg atttcagcgt 303301 caagtgctgc gatgaccgct acgcttaaaa agtcatacga ccgtaagaaa ccgattatca 303361 ttacaggatg gacaccgcac tggatgttct ccagatataa gctgaaatat ctcgatgatc 303421 cgaaacaatc ttatggcagc gcagaggaaa tccatacgat cacacgcaaa ggcttcagca 303481 aagagcagcc gaatgccgca aagcttctga gccagtttaa atggacgcag gacgaaatgg 303541 gcgaaatcat gatcaaggtg gaagaaggcg agaaacctgc caaagttgct gctgagtacg 303601 tcaataaaca caaggatcag attgccgaat ggacaaaagg cgttcaaaag gtgaagggag 303661 acaaaatcaa ccttgcctat gtggcgtggg acagtgagat tgcaagtaca aacgtcatag 303721 gcaaagtctt agaagacttg ggctatgagg taacacttac tcaggtagag gctgggccga 303781 tgtggactgc aattgcgacg ggaagtgcgg atgcatccct ttccgcatgg ctgccgaata 303841 cccataaagc atacgccgct aaatataaag gcaaatatga tgatattggc accagtatga 303901 ctggtgtgaa gatggggctt gttgttcctc aatatatgaa aaatgtcaac tcaattgaag 303961 atttgaagaa gtaatcaaaa aagcagcctg tgtcaggctg ctttttttgc gttaagaagc 304021 gttagcggca gcaagtgatt ccgccttctg aaatgttttg agcacggcgt tcgccaaaat 304081 atgaatgccg gtaaacatcg catttctgtc aaaggtcatg tgcggatgat ggagccccgg 304141 ctggagcccg cagcctagtc cgagcatcgt tgttttcaga ttcggcacct tcacggcgta 304201 aaaatggaaa tcctcgccgc cggtggtgac aagcgggtca tcaagccgct cagccccgat 304261 gatttccgta atggcttctg ccatgatcgc ttcagcttct ttattttgtg ttgccgcagg 304321 aaggctgtgt tctttgtgca gctcgatctt tgcgccaaat gcagcggcgg ccgcttcaca 304381 ggctctttct gtttcggcga ttaatgcctc catggcttca ttggtctgtg cgcgcaaatc 304441 aaggctgaac gatgcttttc ctggaatgat gttagagctt tcaccgccgg cttgcagttt 304501 tgtcattttg acggtatgcg ggatttgcgg gtcaatatga atgagtccga gcttgtgtac 304561 aagaaatgcc gcaatttcaa tgctgttttt cccgaggtgc ggacgggcgc catgagcctc 304621 ttccccgatg atcgttccct caatgtgctg gcttgatccg tgcagaatag aaggagcgca 304681 gcggccgttc tgtgtttcct ggatcggacg gacgtgaacg ccatacaaat agtcgatatc 304741 atcaagcacg ccttcttcta tcattttcaa ggcgccgccg cctttttctt ctgccggctg 304801 aaagataaaa cggattgtgc ccttcggaag ctcaggttgt ttttttagca gcattaacgt 304861 gcccaatgcc attgtcatat gtgaatcgtg tccgcaggaa tggttggcgc gaaatgtgcc 304921 gttaacctcc tgccacagcg cgtcaatatc agcgcgtacc gctacaacag gtgagcctga 304981 gccgatttcg ccgacaaccc cggtgcagtc tgaaaacgtg cgcgtccggc accctaaatc 305041 ctcaagcttt tgtttcaaaa atgaagttgt ctcatattcc ttccagctga cttcagggtt 305101 cgcgtgcaga tgctcgaaga tgtccataat ggtttgtttc atttcttctg aaagcttttg 305161 catggtaaga aatacctcct tctatcagaa tgaattttta ccttctttac tttatttata 305221 ttgaaacagg aagataggct gtatataata tagcacatat tgctactatt cagaataatt 305281 aatattttca aacagagggg atggatcgaa atatgagtat gccagcagcc gaaacacagc 305341 ctaagaaaaa acgtatgaca tttaaaatgc ctgacgccta tgtcctctta tttatgattg 305401 ctttcatttg cgcaatcgct tcatatattg tgccggcagg tgaatttgac cgcgtgacaa 305461 agggggatgt cacgaccgct gttccgggaa gctatcattc aattgaacag tctccggtca 305521 gattgatcag cttttttact tctctacagg atggaatggt tggatcagca cccatcatct 305581 ttctgatttt attcacaggc ggcaccattg ctattctaga aaaaacgggt gccatcaatg 305641 gcctgattta caatgtcatc agcaaattcc gcacaaagca attattattt atttgtattg 305701 tcggcgcatt gttctccatt ctcggaacaa ccgggattgt cgtgaattca gttatcggtt 305761 ttatccccat cggcctcatt gtggcacgat ccttaaaatg ggacgcagtc gcgggagccg 305821 ctgttatata catcggctgc tacgctggat ttaactccac catattatca ccgtcaccgc 305881 tcggtttatc acaatcaatc gcggagctcc ctcttttctc aggaatcggc ctgcgagttg 305941 tgatatacat atgctttttg ctgtcttcta ttatttatat ctatttgtat acgagaaaat 306001 taaaaaaatc aaaagatgcc agtgtgttag gaacagattg gttccctgcg gcaggaatgg 306061 gcgaagccgg taaagaagaa gatcagtcag tgccgtttac cgttcgccat aagctgattt 306121 tggctgtggc gggactctca cttgtcggat ttttatacgg cgctttgaag cttggctggt 306181 cagattccca aatggctgcg acatttattt ttatttctgt ccttgccggt ttaataggcg 306241 ggcttgcggc gaacgatatt gccaaaacct tcattacggg ctgccaaagt cttgtatacg 306301 gggcgctgat tgtcgggatg gcacgaagca tttccgttat ccttgaaaat ggaaagcttc 306361 tcgatactgt cgtcaatgct ttggcttcac ttttggatgg attcagcccg attgctgggg 306421 caatcggcat gtatatcgcc agtgcgctgc ttcattttct catctcttca ggttctggcg 306481 aagccgttgt atttattcca atcctggcgc cgctcgctga tttgatggga atcacgagac 306541 aggttgcggt tgaagcggtt atgcttggag aaggggtcgt caactgtgtg aacccgacat 306601 ccggcgttct catggcggtg cttgccgcca gcggtattcc gtatgtcaag tggctgcggt 306661 ttatggtgcc gcttgctctg atttggttct tgatcgggct tgtctttatc gtgatcggag 306721 tcatgatcaa ttgggggccg ttttaacgat tgctgcccgc cggcttgtac ggcgggcttt 306781 tgagttattc attgcagaag cgcaggctgt tattgtaaca tgtaagccat aagccattcg 306841 taaaagtgcg ggaggaaggt catgaataat ctgcgtaata gactttcagg cgtgaatggg 306901 aaaaataaga gagtaaaaga aaaagaacaa aaaatctggt cggagattgg gatgatagcg 306961 ggagcatttg cgctgcttga tgtgatcatc cgcggcatta tgtttgaatt tccgtttaaa 307021 gaatgggctg caagccttgt gtttttgttc atcattatct tatattactg catcagggct 307081 gcggcatccg gaatgctcat gccgagaata gacaccaaag aagaactgca aaaacgggtg 307141 aagcagcagc gaatagaatc aattgcggtc gcctttgcgg tagtggtgct tacgatgtac 307201 gacaggggga ttccccatac attcttcgct tggctgaaaa tgattcttct ttttatcgtc 307261 tgcggcggcg ttctgtttct gcttcggtat gtgattgtga agctggctta cagaagagcg 307321 gtaaaagaag aaataaaaaa gaaatcatct tttttgtttg gaaagcgagg gaagcgttca 307381 cagtttcggg cagctttttt tataggaaca ttgatttgta ttcactctgc caagttgttt 307441 tgatagagtg attgtgataa ttttaaatgt aagcgttaac aaaattctcc agtcttcaca 307501 tcggtttgaa aggaggaagc ggaagaatga agtaagaggg atttttgact ccgaagtaag 307561 tcttcaaaaa atcaaataag gagtgtcaag aatgtttgca aaacgattca aaacctcttt 307621 actgccgtta ttcgctggat ttttattgct gtttcatttg gttctggcag gaccggcggc 307681 tgcgagtgct gaaacggcga acaaatcgaa tgagcttaca gcaccgtcga tcaaaagcgg 307741 aaccattctt catgcatgga attggtcgtt caatacgtta aaacacaata tgaaggatat 307801 tcatgatgca ggatatacag ccattcagac atctccgatt aaccaagtaa aggaagggaa 307861 tcaaggagat aaaagcatgt cgaactggta ctggctgtat cagccgacat cgtatcaaat 307921 tggcaaccgt tacttaggta ctgaacaaga atttaaagaa atgtgtgcag ccgctgaaga 307981 atatggcata aaggtcattg ttgacgcggt catcaatcat accaccagtg attatgccgc 308041 gatttccaat gaggttaaga gtattccaaa ctggacacat ggaaacacac aaattaaaaa 308101 ctggtctgat cgatgggatg tcacgcagaa ttcattgctc gggctgtatg actggaatac 308161 acaaaataca caagtacagt cctatctgaa acggttctta gacagggcat tgaatgacgg 308221 ggcagacggt tttcgatttg atgccgccaa acatatagag cttccagatg atggcagtta 308281 cggcagtcaa ttttggccga atatcacaaa tacatctgca gagttccaat acggagaaat 308341 cctgcaggat agtgcctcca gagatgctgc atatgcgaat tatatggatg tgacagcgtc 308401 taactatggg cattccataa ggtccgcttt aaagaatcgt aatctgggcg tgtcgaatat 308461 ctcccactat gcatctgatg tgtctgcgga caagctagtg acatgggtag agtcgcatga 308521 tacgtatgcc aatgatgatg aagagtcgac atggatgagc gatgatgata tccgtttagg 308581 ctgggcggtg atagcttctc gttcaggcag tacgcctctt ttcttttcca gacctgaggg 308641 aggcggaaat ggtgtgaggt tcccggggaa aagccaaata ggcgatcgcg ggagtgcttt 308701 atttgaagat caggctatca ctgcggtcaa tagatttcac aatgtgatgg ctggacagcc 308761 tgaggaactc tcgaacccga atggaaacaa ccagatattt atgaatcagc gcggctcaca 308821 tggcgttgtg ctggcaaatg caggttcatc ctctgtctct atcaatacgg caacaaaatt 308881 gcctgatggc aggtatgaca ataaagctgg agcgggttca tttcaagtga acgatggtaa 308941 actgacaggc acgatcaatg ccaggtctgt agctgtgctt tatcctgatg atattgcaaa 309001 agcgcctcat gttttccttg agaattacaa aacaggtgta acacattctt tcaatgatca 309061 actgacgatt accttgcgtg cagatgcgaa tacaacaaaa gccgtttatc aaatcaataa 309121 tggaccagag acggcgttta aggatggaga tcaattcaca atcggaaaag gagatccatt 309181 tggcaaaaca tacaccatca tgttaaaagg aacgaacagt gatggtgtaa cgaggaccga 309241 gaaatacagt tttgttaaaa gagatccagc gtcggccaaa accatcggct atcaaaatcc 309301 gaatcattgg agccaggtaa atgcttatat ctataaacat gatgggagcc gagtaattga 309361 attgaccgga tcttggcctg gaaaaccaat gactaaaaat gcagacggaa tttacacgct 309421 gacgctgcct gcggacacgg atacaaccaa cgcaaaagtg atttttaata atggcagcgc 309481 ccaagtgccc ggtcagaatc agcctggctt tgattacgtg ctaaatggtt tatataatga 309541 ctcgggctta agcggttctc ttccccattg agggcaaggc tagacgggac ttaccgaaag 309601 aaaccatcaa tgatggtttc ttttttgttc ataaatcaga caaaactttt ctcttgcaaa 309661 agtttgtgaa gtgttgcaca atataaatgt gaaatacttc acaaacaaaa agacatcaaa 309721 gagaaacata ccctggaagg atgattaatg atgaacaaac atgtaaataa agtagcttta 309781 atcggagcgg gttttgttgg aagcagttat gcatttgcgt taattaacca aggaatcaca 309841 gatgagcttg tggtcattga tgtaaataaa gaaaaagcaa tgggcgatgt gatggattta 309901 aaccacggaa aggcgtttgc gccacaaccg gtcaaaacat cttacggaac atatgaagac 309961 tgcaaggatg ctgatattgt ctgcatttgc gccggagcaa accaaaaacc tggtgagaca 310021 cgccttgaat tagtagaaaa gaacttgaag attttcaaag gcatcgttag tgaagtcatg 310081 gcgagcggat ttgacggcat tttcttagtc gcgacaaatc cggttgatat cctgacttac 310141 gcaacatgga aattcagcgg cctgccaaaa gagcgggtga ttggaagcgg cacaacactt 310201 gattctgcga gattccgttt catgctgagc gaatactttg gcgcagcgcc tcaaaacgta 310261 cacgcgcata ttatcggaga gcacggcgac acagagcttc ctgtttggag ccacgcgaat 310321 gtcggcggtg tgccggtcag tgaactcgtt gagaaaaacg atgcgtacaa acaagaggag 310381 ctggaccaaa ttgtagatga tgtgaaaaac gcagcttacc atatcattga gaaaaaaggc 310441 gcgacttatt atggggttgc gatgagtctt gctcgcatta caaaagccat tcttcataat 310501 gaaaacagca tattaactgt cagcacatat ttggacgggc aatacggtgc agatgacgtg 310561 tacatcggtg tgccggctgt cgtgaatcgc ggagggatcg caggtatcac tgagctgaac 310621 ttaaatgaga aagaaaaaga acagttcctt cacagcgccg gcgtccttaa aaacatttta 310681 aaacctcatt ttgcagaaca aaaagtcaac taaccgcaac tttagagtaa agggctgatt 310741 gtcaatgtgg gagcagttgt atgatccgtt tggaaacgag tatgtgagcg cacttgtggc 310801 gctcactccg attctctttt ttcttttggc tttaactgtt ttgaaaatga aaggcattct 310861 tgcggcattt cttaccctag ccgtcagttt cttcgtctcc gtttgggcat ttcatatgcc 310921 ggttgaaaaa gcgatttctt ctgttttgtt aggaatcggg agcgggctgt ggcccattgg 310981 ctacatcgtc ctgatggcgg tgtggctgta taaaatcgcc gtgaaaaccg ggaaatttac 311041 cattattcgg tccagcattg ccggcatttc gcctgaccaa cgattacagc tattattaat 311101 tggtttttgt tttaacgcgt ttttagaagg cgcggccggt tttggtgttc cgattgcgat 311161 tagtgcggcg ctgctcgtcg aacttggttt taaaccgtta aaagcggcgg cgctctgctt 311221 gattgcaaac gctgcctccg gagcctttgg ggcgattggg attcctgtca tcacaggggc 311281 gcagattggt gatttgtctg ctcttgagct gtctcggaca ttaatgtgga cactgccgat 311341 gatctcattt ttaataccat tcctgcttgt attcttatta gaccgaatga aaggaatcaa 311401 acagacatgg cccgctcttc tggttgtgag cggtgggtat acagcggttc agacactgac 311461 aatggcggtg ctcgggccgg aattagcaaa cattttggcg gccttattca gcatgggcgg 311521 gcttgccctc ttcctccgca aatggcagcc gaaagagatt taccgcgagg aaggggccgg 311581 cgatgctggt gagaaaaagg cataccgtgc cgctgacatt gcgaaagcgt ggtctccttt 311641 ctacatttta actgcggcga tcaccatctg gagccttcct gccttcaaag cgcttttcca 311701 agaaggcggg ctgttatatc aatcaacgct cctgttcaaa atgccttttc tgcatcagca 311761 aattatgaaa atgccgccga ttgcgccatc tgccatgccg ttagatgcag tctttaaagt 311821 tgatctgctg tcagcgactg gtacagcgat tttagcggcg gtcatcgtga cagggctgtt 311881 cagcaaaaag ttctcctctc gggatgcctt tgcttccttg aaggagacgg gaaaagagct 311941 gtgggtgccg attatgacga tctgcttcgt gatggggttt gccaatctgg ccaacttcgc 312001 agggctcagc tcttcaattg ggttagcatt ggcgaaaaca ggagacctgt tcccgtttgt 312061 cagtcctgtt ctcggctgga ttggcgtgtt catcaccggt tctgttgtca gcaataatgc 312121 tttgttcggc catttgcagg ttgtcacggg agcgcagatc ggtgcgggtt cagatttgct 312181 gttagccgca aatacggcgg gcggtgtcat ggcgaaactt gtttctcctc aatctatcgc 312241 catcgctgcc gcagcggtcg gccaaacagg caaggaatct aaactgttta aaaggacagt 312301 ggcgtacagc ctgattctgt tattgatcat ttgtatatgg acgtttattc ttgcaagatt 312361 aggagtgtaa tagaaaaaag cagtacatgc ccagcatgta ctgctttttt tatgttaatt 312421 tgctttcttt gtcatttcgg ctgttgtttt cactctggct tttcccataa ataaaatggt 312481 aaccgccgcg aggacaattg gaatcaaagc gagcaaaaag acatacgtga tacttgatga 312541 catcgcgtca ataatgcgat tcaggatcgc atcaggaatc tgggaacgtg ttcccgcttg 312601 gaatatctcc tgcgggtcgc caatattttg cgcagcgcct gatcccgctg agcctttcat 312661 accgctgaag gcgtcattca gcttgtttgt gaatacgttt gtttgcaccg ttccgaaaat 312721 ggtgacacct aaggtcatgc caaatgatcg caaaaatgaa tttgtagagt ttgccgttcc 312781 ccgaaagcga ggttcaagat cattcatcga tgccgccggc agcagggaga agttaaagcc 312841 tacaccaaag cctgaaatca tcataaagac tgtcagccat acccgtgctg tgtcaggcgt 312901 catattggaa agaagcagca tgccgataaa gaaagctata acagatatca gcatcaaatt 312961 gcggaagctt gccttcgttt ggaagatccc gccgatcatg cttccgatga ctgatccaat 313021 catcatcggc gtcagaatga agcccgcgct tgtcgccgag ctgccgtaga ccgcctgaac 313081 gaaaatcgga ataaataccg ctaaaataat aaatgttccg ccatacagga aagcgagaat 313141 ctgtgctgtg gcaaacaagc ggttcttaaa catccagaaa gaaataatcg gctcttctgc 313201 ttttctctcc acaataaaaa aggcaatgaa gaaaacggcg aatacaataa acagcccgat 313261 gatctgaatg gagttccaat cgtatgtttt gccgccaagc tcaagggcga acatcaggca 313321 tacaatggat acgactaagg taatcgcgcc gccccagtct attttctgct ttctgtgctc 313381 cagagattct ttgtagtagc gaataatgaa aaacaatgac aatgcgccga tcggcacatt 313441 gatgtaaaac acccagtgcc agctgatcga atctgtaatg atcgcgccta agagcggacc 313501 aagaacactg gataatccaa atacagcacc gaacatgccg gacatttttc cgcgtttttc 313561 cggcggaaac aaatcaaaga taatggtaaa ggcaatcggc aggagcgcgc cgcctccgat 313621 cccttgaatg gcccggaaga tgatcagctg attcatcgtc tgggcaatcc cgcataaagc 313681 agaaccgatt aagaaaaaaa taagtccaaa caggaaaaaa cgttttcggc cgtacatatc 313741 ggaaagcttg ccgtaaatcg gcatgccagc cataaccgcc accatatagg atgccgtcac 313801 ccaggcaaat ttatcgaagc ttccaagatc ggctacgata ttgcccatcg cggtggcaac 313861 aatcgtattg tccattgcag acatcaagat gcccagcagg agaccgagga ccacaaattt 313921 ggtggaagcc tgttttgctg ttgttgtgtc catttgttct acctcctctt acttttctat 313981 gtaagttctg atatcatgat aatagtttga ttgttgaata tctcgattat caagataaac 314041 tcgattttat agggaggact gtcagttgtc aacaagaaat tccagaagtg agttggaaaa 314101 gactgctgtt cagctttttc gaaaactggg cacaagaacg gttctgtttc atcaggcagc 314161 cgctcaagct ctcggtctgt ttcccaccga tttgaaatca gctgacattt taaatgaagc 314221 agggccgatg acggccggag agctggggaa aaaaaccggc ctcagcacgg gttccgtcac 314281 ggcgcttgtt gaccggctgg aaaaagcggg gtatgtggct cgtgaaaagg acccgaacga 314341 tcgcaggaga gtcgtaatcg tccctttgac tgcttcgaaa aaacatataa aggatttgtt 314401 ccgtcctctg tctgagtcaa cgatggattt gtgccgcgaa tatacggaag aggagctgga 314461 actcattttc agttttgtag gcaaagctgc cgatattatg gaggaagagc ttgaacgtct 314521 gaaacagtaa gtgaatttgt gcatagcttg gcccgttccc gaataaattg tacaagttac 314581 ataagagaag ggagtacggg ccggtgaaca tttttttgag ctatattgtg ctgggactgt 314641 ccttgtctgc gcctgtgggg ccagtgaatg cggcgcaaat agacaaagga attaaaaacg 314701 gtttttggca tgcatggatt ttcggtttag gcgccatgac agcggatggg ctgtacatgc 314761 tttttatcta tttcgggctg tcgcagttct tgaccgctcc atttgtgaaa acgtttttgt 314821 ggctgttcgg cttttttgtc ctgacctata ccggaattga aacgctgaaa aacgtcagag 314881 aaccgatgga tgtgcgaagc tcgcggggga aaccgtcata caggaaaaca ttcgcatcgg 314941 gttttctcat ttcattgtca aacccattga gcatcctttt ttggcttgga atttacggaa 315001 gcattcttgc gaaaacagca gaggcctaca atatgaatca gcttctaatc tatagctccg 315061 gcatcatgat cggcatttta atctgggatt tctgcatggc tatcacagcc agtacgttca 315121 gaaacctgct tcatgaaaag ctattgagag gattgaccgg aatcgccggt gtatccctcc 315181 ttgtgtttgg cttttacttt ggttatcagg gcatcaaaca gttattgggc tgattcatga 315241 aggacagtca cctgccgctt ccagttttaa tatagtatcc agatgatact ggaggtggat 315301 caatggtgaa tgggatttac accaaaagtt ttctggaacg tattcaggaa gagcttcctg 315361 aatggcaaag aatcgctttt gagctgctgg cagaaactct gggggacgac gcggatacat 315421 ttccgtgcat tcccggacgc caggcgtttc tgactgatca gcttcggatt gcttttgccg 315481 gagatccgcg ggaaaaccgc acagcggagg aactggctcc gttgcttgcg gagtacggca 315541 agatatcgcg ggacacggga aaatacgcat ccctcgttgt gttgtttgat acaccggaag 315601 atttggcgga gcattattcg attgaagcgt atgaagagct gttttggcgc tttttaaata 315661 gactgagtca tcaagacgaa aaagaatggc cggaagacat tccggccgat cctgagcatt 315721 ataaatggga gttttgtttt gacggcgagc cgtatttcat tctgtgcgct acaccggggc 315781 acgaggcaag aagaagccgg agctttcctt tttttatggt cacgtttcag ccaaggtggg 315841 tgtttgatga cctaaatgga tcaactgcat ttggccgtaa catgagcagg ctgatccgat 315901 ctcgtttaga ggcctatgat caggctccga ttcacccgca attaggctgg tacggaggaa 315961 aagataatcg tgaatggaag cagtatttcc tccgtgatga cgaaaaacag gtatcgaagt 316021 gcccgttttc ttatttaaag aacatgttca acaaaatgaa ataaatcaag gactggcagg 316081 gcgatcttta tgaccctgct ttttttgata gatcatggta acgatggcga taatcacgag 316141 aaaacctatg ctgacgaaaa aaccgggccg gcttgatttt tcaaacaatg taccggacac 316201 agctgcagca atcagaacca tcgctaaata aatttgcgtt tttcccatgc cctcgggatc 316261 agtcagcttt ttgctggaga acaggataaa cagccaagtg tataaaagca taagccccgc 316321 agctgttgtc atatgctcat aaatgttttt aggcagcact aacgacaaaa taatggagag 316381 gacaagcccc gcaaacgtca gcccaagtgc cggccagcat atttttttgc cttcctttag 316441 agtaaagcat ttcggcgcgt cgccgtcatc agccattgta caaagcaatg tcgtaaccgc 316501 aaatagcgaa gcgacaaggg tcgagaaccc tgcgatgatg aaaatcccgt taaatatatc 316561 aaggatgatc tcaaggttat atccttttaa tgacgtaatg aacggactgt cctgttcagt 316621 aaacgtgtgt aacggaacca aaagcagagc aagcccgatt gaaatgatat aaataatcgc 316681 cagcgtcgcc agcatcagtt tccctgattt agacgcttcc tcaggttttt ttaagtgaac 316741 cgccatcagc cccatgacct caattccgcc aaaagcgtaa aacgcgtaga ttaaacctgt 316801 ccacagcccc atggcgccgt atgggaaaaa ctcactcgtc ttatttggaa catgtatgcc 316861 atgatttccg ccggacagga taccgcataa agccaggatg gcaatgacaa taaacataaa 316921 aatagcagct gttttaatga ctgccagcac gttttctgtt ttttcaaaga cggacaggcc 316981 ggtgaaaata ataaggagcc caagtactgc gtagattgag gcaaacaccc atagcggcac 317041 ttgaggaaac caatgcttcg taaagagcga aatggctgtc agctggcttc cggtaatcag 317101 catttctgat gtccagtaca cccagccgtt gctgaagcct gcccatttgc cgaatgcttt 317161 tcgggcatac gcacaaaacg agcccttttc cggctgcttc gccgatagct tggcgagctg 317221 ttcaaagaca aaatacgtac cgatccctgc gatcagaaat gaaaggagaa cggaaaaacc 317281 gctttttaca attgcgatgc tggaaccgag aaagaagcct gttccaatcg tgcagccgac 317341 tccgatcagt gacagctgcc accaagccag attccctttt ggctggtctt tttttgtttg 317401 gctcattatt tattcaaccc cttttatcta aggttagatt gtgatctgtc caaagcttat 317461 atacatcgga tttttgcctc tttttacatg gagaaggaag cagacgctca tactaatgaa 317521 aaaaggagca aaccaatgac acagcaatat attgtggagc cgaaaaaagg gcttgggctg 317581 aagctgaaaa aggggcagat tttaaaggtg gttgatgtag aagggcagca ggtggctgat 317641 tttgtcgcat accatgccaa ggatttttat gaacaccttg atcagggagc gacgatagac 317701 gccaatcact ccattcatgt gaaggtcaac gaccatctct actccaacct gtataagccg 317761 atgttaaccc tgattgaaga tacggtcggc aagcatgatc tgctgttgcc cgcctgccgt 317821 cctgatatga acaggctctt atatgggaag caaaaggatg agtttcagga tacgtgctat 317881 gacaatatga accgtgcgct tgagcagttt ggcgtaccga agccccacat gcattaccca 317941 tttgcgattt ttatgaatac tgtccttgat gagaaaggga atctgtctgt ggaaacgccg 318001 ctttcgaatg ccggagatta tgtaaggctc agggcggaga tggatttaat tgtcgcgttt 318061 tcttcctgcc cgattgaaaa agggaaatgc aatggcgaca gtgtgacatc catacgggtt 318121 gaagtcagct gatctctctt gttcacagtg aatgaagacc tgtgctatat ttaataggga 318181 tacataacag tcatgattca ttttcattga tttagggaaa tgatcagtaa taagggaaaa 318241 tgtacaggag gaatgattgg gatgagcatg caggaaaaga ttatgcgtga gttacatgtg 318301 aagccctcaa ttgatccaaa gcaagaaatt gaggaccgag tcaatttttt aaaacaatat 318361 gtaaagaaaa ccggtgctaa aggctttgta ttgggaatca gcgggggcca ggattcaaca 318421 cttgcgggaa gactcgctca gcttgcggtg gagagcattc gcgaggaggg cggagacgct 318481 caatttatcg cggtccgtct tccgcatggc acacagcagg atgaagacga tgcccagctt 318541 gctttgaagt ttattaagcc ggataaatca tggaagtttg atattaaatc gacagtcagc 318601 gctttttctg atcagtatca gcaggaaaca ggcgatcagc tgacggactt taataaagga 318661 aacgtaaaag caagaacaag aatgatcgcg caatacgcga tcggcggcca ggaaggtctt 318721 cttgtgttag gaacagacca tgctgctgaa gcagtgactg gtttctttac gaagtacggt 318781 gacggcggag cagacctcct gccgctgaca ggcttgacga agcgccaggg aagaaccttg 318841 ctgaaagagc tgggtgcacc ggaacgctta tacttaaaag aaccgactgc cgatctgctc 318901 gacgaaaaac cgcagcagtc ggatgaaaca gagcttggca tttcctacga cgagattgac 318961 gattatctcg aaggaaaaga agtatcagcg aaagtatcag aagcgctgga aaaacgctac 319021 agcatgactg aacataaacg ccaggttccg gcgtctatgt ttgatgactg gtggaaataa 319081 gttgaagaaa gcccgctctc ggagcgggct tttgtcgtgt acagaagctt tatttgatgc 319141 ggatatgatt cagctttacc attaatctgt cggcgaacct tcggaggctg cctcttgtat 319201 caggatctaa tgggagttcg gctctcgcgg caatgttctc tgccacatcc tgaatcgaca 319261 ggttgtctgt ttgaatgtgg tcctcaaaaa tgggtgatga taatccttca acacagcggt 319321 caatttgttt ggcggcccat gagttttttc cttctgctct ggtgcgcagc ctttttaaca 319381 aggtttcctt tgaagccatt agtgtaaagt ggtgaacgat cctgccttcc tgtctgagcc 319441 tgccgatgat ctcattgaag tattcagggt gtacaatcgt cataggcaca ataaggatgc 319501 cgcggtatgt atctgtcaga gaagctagca aactgtaatt gaacgcccgc cataaaggat 319561 agctttgaaa atcgtccttt gcgatctcct gcggcaccat ggagcgcagc gcaaaaccca 319621 ttttctcggg atcatacacg taagatgggt tcagccttct gtgcagttcg aaggctgttt 319681 gtgtttttcc cgaaccgaat gccccgttta tccaaatgat catcgccatt tctcccttcc 319741 tatttatcat acagaaaaag acccttccat cgaagagtca gctggaaaaa caataaaggc 319801 ggaaggtttt aacgcttttt tgcgtcgaag tattaaaata cctgcagaaa tgttgtacaa 319861 tgaatgtcat tcaggcaaaa atggctacaa caaagcgcac tataagcttg accggtaaag 319921 ccggtatcta tataaatatt cgctaaataa gcatataatg aatatataat ttcattcctt 319981 aggaggattt cgccgaagat gaacgctaaa cgagccatcc cagtaagaga aagaaatatc 320041 gtcctgatcg gattcatggg tgtaggaaaa acaacaatcg gccaattggt cgctaaaaaa 320101 ttatatagag attttattga tattgaccag cagatcgaaa aggatttcaa tatgtcaatt 320161 cctgagatat ttgagaaaaa gggagaagac tttttccgga aaacggagaa ggaatatatt 320221 ttagacatct gccatcataa acgattcaaa atcgtatctc tgggcggggg atcttttaaa 320281 caagaagaaa tcagaaattg ctgtctggaa aactgtctcg tgcttcatct ggacctgtca 320341 tgggagaact ggaagcagcg cgcggattta ttgatcgaaa gccgccctgt actgcataac 320401 cgttcaatgg atgaaatgga acagctgttt aacgaaagaa aagtcattta tgacaagcac 320461 aattcaaaag tggcaacaga caacctttcc ccggaagagg ttgccgatta cattgttgag 320521 acattaaaaa ttggctggga tctttatcag ccgatgtaaa aagccgtgcg cagcgcacgg 320581 ctttttttat cgttttatcc cttgtatcaa aatcgctttt aaacaaaagg agatgggctg 320641 tccgttttgg ttcaatgtaa tacagaacgt gtcgcgtgct tcgtctgatg cgtgattcaa 320701 gtgggtaatg atttgttttt ctcggtcagc gggggttccg cctcgtttga tccagctatc 320761 gtattgaatc ggcaagttcc acttttggat gtcttgatag gccagttgat tggcgctgaa 320821 catcgcctgc cattctgata atgagctttc acgaacatgg gaagggtctc gaagccggtt 320881 caaatgattg acaaactcat caagaacggg atcttcaggc gcgtaatgat caactaagag 320941 aaaacgtccg tcctgtttta gtacgcgtgc aacctctctg acagctttgc ggacatctga 321001 aaaatggtgg gctgcgtatc ggcaggtgat gatgtcaaat gaatcgtcgg ggaaggggag 321061 tgactctgcc gttccttgct gaaagcgtac gttttcaact cctttttctt gcgcgaagga 321121 ggacgcaacc tcaaccatct ctttcgttgc atcaacaccg atgcactcct gtacataagg 321181 agaaaatgcc agcgccgtat ggccggcgcc cgctcctata tccagcactc gatgctctgc 321241 ccggcattcc gctgttttga tcatcaaccc caaatcttcc ccctcggcaa ataccttttc 321301 atcccgatac atctcggcgt ttttagaaaa cggtgtttca tttgtcattt gaaccagctc 321361 cttcttttcg taaatgatga tatggattat gttagcaatt tctgttatga ttcgtccaag 321421 atataaaaat gatgaaaatg ataggttcaa cctatggagg ctgaaatgga tattaaagtg 321481 atggaatatg cagcggaaat tgcccggcgc caaagcttta caaaggcggc ggaacatctt 321541 catatcgcac agccgtctct cagccagcaa atcaaaaagc ttgaggctga gctggggctt 321601 accctttttc acagatccca tggctctgtt acactgacac ctcacggcag gcgtttcatt 321661 gaaaaagccg aggacatcat tcgttccaga gatgatttgc ttcgggaaat gcaggagcga 321721 tcacagggaa tcggtcataa attatccatc gggattcctg ctgtaacagg gagatatctc 321781 tttcctccgc tgctgaagca gtttttggcg cgctatcctc atgtggaggt tcagcttgtt 321841 gaaaaagatc cggtttcatt agagaagatg acggcaaagg gagaagttga cctttctgtt 321901 ttatccttgc ccatcgagga tgaacggctc tccattacac ccttgctcac ggaaccggtt 321961 gttctcgcgg tgccgaagga aaaacaaagg tggatgccgc cggaattggt cgcgctgatt 322021 gagaaagcgc tggaagaaga tgagggacgc cagccgtgtg tgccgattga catggtaagg 322081 aacgtgccct ttattctgtt aaaagaaggc ttcggctttc gcaggacagt tctcgatctc 322141 tgtgcggaaa gcggctttaa gccgaatgct gcctttaaga cgagccatat tgaaaccgcc 322201 caatctcttg tggctaacgg attaggtgtg acaatggcac cgaatatggt cagaagggat 322261 aaagatccgg gtgtgatcta tttatcgatt caatccgcgc catcacgaac cctcgtcttt 322321 gtctttttaa agaaccgcta tgtcagtctg acggcccagg cctttatgga actaagccgg 322381 gaaagtctta aacaaacgtt tgatgaaggc tgtctgggaa acaaagatga aaatatttag 322441 aaaacaaaga cgaaacgtgg tagtatagga atacaaacta aatcttataa aacaaagggg 322501 aataatcgga aatgcaacta ttcgatctgc cgctcgacca attgcaaaca tataagcctg 322561 aaaaaacagc accgaaagat ttttctgagt tttggaaatt gtctttggag gaacttgcaa 322621 aagtccaagc agaacctgat ttacagccgg ttgactatcc tgctgacgga gtaaaagtgt 322681 accgtctcac atataaaagc ttcggaaacg cccgcattac cggatggtac gcggtgcctg 322741 acaaggaagg cccgcatccg gcgatcgtga aatatcatgg ctacaatgca agctatgatg 322801 gtgagattca tgaaatggta aactgggcac tccatggcta cgccacattc ggcatgcttg 322861 tccgcggcca gcagagcagc gaggatacga gtatttcacc gcacggtcac gctttgggct 322921 ggatgacgaa aggaattctt gataaagata catactatta ccgcggtgtt tatttggacg 322981 ccgtccgcgc gcttgaggtc atcagcagct tcgacgaggt tgacgaaaca aggatcggtg 323041 tgacaggagg aagccaaggc ggaggtttaa ccattgccgc agcagcgctg tcagacattc 323101 caaaagccgc ggttgccgat tatccttatt taagcaactt cgaacgggcc attgatgtgg 323161 cgcttgaaca gccgtacctt gaaatcaatt ccttcttcag aagaaatggc agcccggaaa 323221 cagaagtgca ggcgatgaag acactttcat atttcgatat tatgaatctc gctgaccgag 323281 tgaaggtgcc tgtcctgatg tcaatcggcc tgattgacaa ggtcacgccg ccgtccaccg 323341 tgtttgccgc ctacaatcat ttggaaacaa agaaagagct gaaggtgtac cgctacttcg 323401 gacatgagta tatccctgct tttcaaactg aaaaacttgc tttctttaag cagcatctta 323461 aaggctgata aatgtgaaaa gccgccgcat atcatcaggc ggtttttttc tgcaaactgc 323521 cggaatgaga acagactgga gacgaataga tatgaaacaa agaatcattg atgaattaaa 323581 acggatcgag cagtcatacg gagtcaaaat cgtgtatgcc gtcgagtcag gaagccgcgc 323641 atggggattt ccctcgcagg atagtgatta cgacgtccgc tttatttatg ttccgaaaaa 323701 ggagtggtac ttttcaattg agcaggagcg tgatgtcatt gaggaaccga ttcacgattt 323761 gctggatatc agcggctggg agctgagaaa aacgcttcgg cttttcaaaa agtcaaaccc 323821 tccgctactc gaatggctgt cctcagacat tgtgtattat gaagcattta cgaccgcaga 323881 gcagttaaga aaactccgca cggaggcatt taagcctgaa gcaagcgtgt atcactatat 323941 caatatggcg agaaggaacg tcaaggatta tctacaagga caagaggtca aaattaaaaa 324001 gtacttctac gttcttcggc ctattttggc ctgccaatgg attgaaaagc acggaaccat 324061 accgccaatg gactttactg ttttgatgaa tgaacttgtt gctgaacccg agctgaaggc 324121 tgaaatggaa accttgcttg aacggaaaag aagaggggaa gagcttgacc tcgaagcaag 324181 aatcgatgtt attcaccaat tcattgaaac ggaaatcgaa agaatcatgg aagcggcaaa 324241 agaactgaag gcagagaaaa aagatatgac atctgaattg aaccgtttgc ttttgaatac 324301 ggttgaagaa gtgtggaagg atggaggaag ctgatgtttt ttgtcgcttc cttttctcct 324361 ttattcgaca gaatcccccc ccgactttct aactatctga ttgtggcaaa cccacaaaaa 324421 taatcagaat ctttgtattt tgagaatatt gtgaacgctg gttttgtcca tttacaataa 324481 actcatacaa atacttctta gattgcgggg tgttgaggtt ggaagtgatc acaagagatt 324541 ttttcttatt tttatccaaa agcggctttc tcaataaaat ggcgaggaac tggggaagtc 324601 gggtagcagc gggtaaaatt atcggcggga atgactttaa cagttcaatc ccgaccattc 324661 gacagcttaa cagccaaggc ttgtcagtta ctgtcgatca tttaggcgag tttgtgaaca 324721 gcgccgaggt cgcacgggag cgtacggaag agtgcattca aaccattgcg accatcgcgg 324781 atcaggagct gaactcacac gtttctttaa aaatgacgtc tttaggtttg gatatagata 324841 tggatttggt gtatgaaaat atgacaaaaa tccttcagac ggccgagaaa cataaaatca 324901 tggtcaccat tgacatggag gacgaagtca gatgccagaa aacgcttgat attttcaaag 324961 atttcagaaa gaaatacgag catgtgagca cagtgctgca agcctatctg taccggacgg 325021 aaaaagacat tgacgatttg gattctttaa acccgttcct tcgccttgta aaaggagctt 325081 ataaagaatc agaaaaagta gctttcccgg agaaaagcga tgtcgatgaa aattacaaaa 325141 aaatcatccg aaagcagctc ttaaacggtc actatacagc gattgccaca catgacgaca 325201 aaatgatcga ctttacaaag cagcttgcca aggaacatgg cattgccaat gacaagtttg 325261 aatttcagat gctgtacggc atgcggtcgc aaacccagct cagcctcgta aaagaaggtt 325321 ataacatgag agtctacctg ccatacggcg aggattggta cggctacttt atgagacgcc 325381 ttgcagaacg tccgtcaaac attgcatttg ctttcaaagg aatgacaaag aagtaaaaaa 325441 ggagagatta tcatgacaac accttacaaa cacgagccat tcacaaattt ccaagatcaa 325501 aacaacgtgg aagcgtttaa aaaagcgctt gcgacagtaa gcgaatattt aggaaaagac 325561 tatccgcttg tcattaacgg cgagagagtg gaaacggaag cgaaaatcgt ttcaatcaac 325621 ccagctgata aagaagaagt cgtcggccga gtgtcaaaag cgtctcaaga gcacgctgag 325681 caagcgattc aagcggctgc aaaagcattt gaagagtgga gatacacgtc tcctgaagag 325741 agagcggctg tcctgttccg cgctgctgcc aaagtccgca gaagaaaaca tgaattctca 325801 gctttgcttg tgaaagaagc aggaaagcct tggaacgagg cggatgccga tacggctgaa 325861 gcgattgact tcatggagta ttatgcacgc caaatgatcg aactggcaaa aggcaaaccg 325921 gtcaacagcc gtgaaggcga gaaaaaccaa tatgtataca cgccgactgg agtgacagtc 325981 gttatcccgc cttggaactt cttgtttgcg atcatggcag gcacaacagt ggcgccgatc 326041 gttactggaa acacagtggt tctgaaacct gcgagtgcta cacctgttat tgcagcaaaa 326101 tttgttgagg tgcttgaaga gtccggattg ccaaaaggcg tagtcaactt tgttccggga 326161 agcggagcgg aagtaggcga ctatcttgtt gaccatccga aaacaagcct tatcacattt 326221 acgggatcaa gagaagttgg tacgagaatt ttcgaacgcg cggcgaaggt tcagccgggc 326281 cagcagcatt taaagcgtgt catcgctgaa atgggcggta aagatacggt tgttgttgat 326341 gaggatgcgg acattgaatt agcggctcaa tcgatcttta cttcagcatt cggctttgcg 326401 ggacaaaaat gctctgcagg ttcacgtgca gtagttcatg aaaaagtgta tgatcaagta 326461 ttagagcgtg tcattgaaat tacggaatca aaagtaacag ctaaacctga cagtgcagat 326521 gtttatatgg gacctgtcat tgaccaaggt tcttatgata aaattatgag ctatattgag 326581 atcggaaaac aggaagggcg tttagtaagc ggcggtactg gtgatgattc gaaaggatac 326641 ttcatcaaac cgacgatctt cgctgacctt gatccgaaag caagactcat gcaggaagaa 326701 attttcggac ctgtcgttgc attttgtaaa gtgtcagact ttgatgaagc tttagaagtg 326761 gcaaacaata ctgaatatgg tttgacaggc gcggttatca caaacaaccg caagcacatc 326821 gagcgtgcga aacaggaatt ccatgtcgga aacctatact tcaaccgcaa ctgtacaggt 326881 gctatcgtcg gctaccatcc gtttggcggc ttcaaaatgt cgggaacgga ttcaaaagca 326941 ggcgggccgg attacttggc tctgcatatg caagcaaaaa caatcagtga aatgttctaa 327001 gcgggactaa atgggcatcc tccctgcggg ggtgtccatt tcatccatat actataaaaa 327061 agaggaggaa gtgccataga aaacacacag ctgattattt cgatttgtat ttatatggcg 327121 ggaatgctgc taatcggcta ctttgcttac aagcgtacgt cgaatctgac ggattatatg 327181 ctgggaggac gctctttggg tccggcagta accgctctca gtgccggcgc tgccgatatg 327241 agcggctggc tgctaatggg gcttccgggc gccatgtttt ctactggtct gagcggcgct 327301 tggatcgtca tcggactttg ccttggagcg tgggcgaact ggctttacgt cgcaccacgg 327361 ctgagaacct atactgaaaa agcggggaat tctattacaa ttcccggatt cctggaaaat 327421 cgcttcggag atcaaacaaa gcttctcaga ctgttttcgg gaattgtcat tttagtcttt 327481 ttcacgtttt atgtatcgtc cggaatggtg tccggcggcg tcttattcaa cagcatcttg 327541 gggatggatt atcacaccgg cctgtggatt gtgacgggtg ttgttgtggc atataccctg 327601 tttggcggct ttttggcagt cagctggaca gattttgttc aggggattat tatgtttgcc 327661 gcactcattc ttgtgccgat cgttacgttt ttccacacgg gaggagcagg tgatacagtt 327721 gctgaaatcc gctctgtaga tcctgatatg tttaatattt tcaaaggaac gagcgtcctt 327781 ggcattattt ctttgtttgc ctgggggctg ggatactttg gccagccgca tattattgtg 327841 cgttttatgg cgataacgtc tgtcaaagag atcaaaagag cgcgcagaat tgggatgggc 327901 tggatgattt tgtctgcagt aggcgcagtg ctgaccggtt tgggcggaat cgcttattac 327961 catcagcgcg gcatgacact gaaggaccca gagacgattt ttattcaatt agggaatatc 328021 ttgttccatc cgattatcac gggttttctg atttcagcga ttttggccgc gattatgagt 328081 acaatttctt cccagctgct tgtgacatca agctctctgg tagaagattt gtataagtcg 328141 atgttcagac gctcagcttc agataaagaa ctggtgtttt taggccgact ggctgttctg 328201 gctgtttcaa ttgtcgcgtt ggttctggct tgggagaaaa ataacaccat ccttggattg 328261 gtcagctacg cgtgggcggg cttcggtgca tcattcgggc cagttgtact gctcagtctg 328321 ttttggaaac gaatgaccaa atggggggca ctcgccggca tgattgtggg agcagcgact 328381 gtaatcattt gggcgaatgc cggtctttcg gactttctgt atgaaatgat acctggtttt 328441 gctgcgagtc tattatctgt cttttttgtc agcatattga cgcaggctcc gtcacaagct 328501 gtcacagacc agttcaacga ctaccaagat acaatgtcgc aataaagatc gaaaggagga 328561 ggaaggggct gtcccttttt cctcttttct ccttttaagc ggccattttt ttcttttgga 328621 aacaaacgta tttttttcta tacaaaaaga ccccgtatgg atatgattaa agtaaaaaaa 328681 gtataggaga aaaaggtatg gaagagcttt tagagagagt tttttcattt tcagatgttg 328741 ataagctaat tgattttatt agctatgaac tgcaaaagcc agtgatactg gaaagcgcgg 328801 atttcttttt gttagcctat aattcttact atattaacca ttttgattct gccaaccagc 328861 agactatttt ttcgaaaaag tgtccggtcc agatttttga gaggtttctg aaggacggaa 328921 ttattgaaaa attgaaaaca gagcctgagc cttttcgcgt caataaaatt gaaagcattg 328981 ggttaaacca gagggtggtc gtgagtgcaa agcacaaagg ggaagtcatg ggctacatct 329041 ggattcagga gctggaccaa aatctgacgg atgaagagct cgactttttg tacgagacct 329101 ccttccatgt cgggaaaatc atttataaaa cgaataaatt gaaacaggaa aaggaagaaa 329161 aagcagagga tctcatcaaa cgggcgatct atcagcaatt tacctctgag aaggaactca 329221 gacgggaagc tgaaaggatc aacaccgtgc tgccttccat gttttcagtt gttatcctgc 329281 acgccgcaaa tggggatggg gaagcggttg aggatttaaa ggaaaatatc aggtcgtacc 329341 tgaatttacg ggataaggtc agtcatgtct taacgatcga atcaaacatt gtcatcgtcg 329401 tagcgagttt ttcccaaaaa agctccgtct cctcagcagc ttctgagttt attaacaagc 329461 tgttaacaca ttttcacttt caaaaaatac ctacccctat ttatatcggt atcggaaacg 329521 aatataatca cctattaaaa cttggcaaga gctacacaga agcacttgaa gtcatcaaag 329581 ccgcagaaat caccggcaat caggaaaaca ttccatatga atatgccaaa ctcggcattt 329641 accgctattt agaaagcatc gaacagaaaa atgaattttt agaatacgag aataaagatt 329701 tagctttatt aaaagcaaaa gacgaagaaa gcagcactga gctgctcaaa accttggaaa 329761 tctatctcct caacaactgc aaaacaaaac cagcggcaga acagctgttt attcaccaaa 329821 atacattgaa ttaccgcatc aaacagatta ctgagatgac gtcgatcgat ttaagcgatt 329881 tcagaacgcg gtgccagctc tatctcgatt tgatgctgat gaaaaagaaa taaaaaagaa 329941 accagtactt gtactggttt cgtcttcact taaaatcctc tgtaaacata cggatcatca 330001 ggttttttaa tggtattcca gtcagttact ttgacgacag ggagagttga cttgaatggc 330061 tggtaatatt ctgaggccag agtgccctta atgtgaatcc attcatcatc cttgatgtcc 330121 atgtccttcg gaaattccac aagcatcccg tacacgccgg aatcagcgat acagtgaatg 330181 atgccaaacc ttaatacgaa cagctgattt ttgttaattg cgtttccttt gtaagcaaat 330241 ccatgaaatt ctatcgtccg tccgagaaat tcacccggat agttatagat ggtttccatt 330301 ccttttagga aatcgtcatc ggtcagagaa atctcttttt tgctggaata cttattaaac 330361 agctgtttca tttgtttgtc atagctgtct tgcgcgtaat aaaggctggc atcaggccgc 330421 aaatactgtg tttgggagta gtgatctccg ctctccatcg ccttaaacga gaaccctttt 330481 gttttgacta tggatgagtc aagcgttgca atcgggaaga agatgcctga caccaaagga 330541 aaaagaaaaa caacataaat caaataacgc tgataaaatg gcttgttttg ttcatggtca 330601 tgctcgtgat catggccgca cccgcaatca tggtcatggt gatgtccgct tttttcaggc 330661 gacttgataa atagatatgc ttggacggcg gtcagaatgg ccagcaggaa gatcgcaata 330721 aaggaaagat aggcatattt catattgata tattttgtta gatttcctga ggcatgcaga 330781 tgataaaaga aaaacgtaaa tcccatcagc accaataaac gaaacatcca atcacccctt 330841 taccagtagt gatcccgcta aaacaatcac gacaatgtat gtaatcagca ggaaaacaaa 330901 tcgttttttg aaggccgcaa gcatcatcaa tagattctta atatccacca ttgcaccaaa 330961 gacgagaaag gcgattaacg atcctaatga aaacgtgctg ctgaaggaag acgcgatgaa 331021 cgcatcaact tctgaacaaa gcgacaggac aaacgccaga cccatcatca cgagggaaga 331081 ggatacatca ttctgcccga tcgcaagcag agtggatgtt ttgacatacg tctgcatagc 331141 ggctgcgata aaggcgccga tgattaaata tttccccacg gagaaaaatt catcaatggc 331201 atgccgcaag gtcccgccca gtttttggag caaggtgccg tgatgatgat ggtggtgccc 331261 gggttcatca ggctttaaaa gctggttatc cttaaattga taggataaga tgaccccgat 331321 gatcagcgaa acggcgagag ccagtccgcc tctgtaaaag accacgctcc atctattccc 331381 gaacgcaata taagtagaaa ataaaacgat aggattaatg ataggcgcgg tcagcatgaa 331441 agcaacgccc gcatgcagag gaactccctt taacagaagc cgcctcgtaa tcgggatgat 331501 gccgcattcg caggcgggaa ataaaacgcc ggccagcgca ccgaataaaa cggcgagaaa 331561 acggtttttc ggcatgattc ttgcaatcat ttcttcagaa acaaacattt gaatgattcc 331621 ggaaagtatg acgccaatca gaataaacgg aatggcttct attaaaatgc tgataaaaat 331681 agaattcagc tgaagaaaag atgattgtgc tgtcacaata aaacctccgc tcatgttaag 331741 ctgcctttct tatgatacca gaaaaaaagg cactgcttgt ttgacggagg aggggaaagg 331801 atcgtttcac tttggttagg attccaaaaa gccgagtagg atactgcctg tttctgcagc 331861 ttcttttccg agccaaatca ggtgtcccca tgagtgaagc aaacagagaa cagcgccacg 331921 aatgtgctct tttgcatgat gtgcatgtga caagtcaacc aatccgtcat aaacactttg 331981 cataatcagc acgggacata tgatggcttg caggtctttt aaagagacag cggcggtttg 332041 tgacaagtca atcagaaatc cttcacccga gcgctgccgg ctgttcattt tccgaaatgc 332101 ttctatgtct ttttcattca tcaaggactt gattcgctga aacggaagcg tgctgaattg 332161 ggggctcata gctcgaaaca tcaaacgcgg gaaagcgtta ttcaaggaag aaatcagctt 332221 ccatatccac ttttccaccg gcgggcggaa gagaatttcc cccaatttat attcagtgtc 332281 ttttggggtg agccactctt tggtgactgc ggattgcagg gtcaatgtat ttactctttc 332341 cggataatgt gaggcaaagc atatgccgct cggccctcct gctgagatgg cgatcacatg 332401 gacactctcg atttgtagat gatctaataa tttcacatag aaacggcagg cattggcaag 332461 actttttcca atttcttttg acgtccgtcc atagccaggc cttgaaggcg taatgatgga 332521 atacccttgt tcaatcaacg ctgtgtatcc gaattcctcg taacaatttg aatgcccgcc 332581 atgcatgaca aggatcggag ttcccttgcc tgtcacagaa tattctagtg taccgccatc 332641 gaaggtgatc gtttcaactc gtcttttcat ctgtttcacc caattggttt ttgcctatta 332701 tagagttttc agcaattgac cacaaggtag aagaaatgaa taaacaaagg cccttgaaat 332761 atgatatact ttgtattgat attcattctc aattaaaact ttgatataga tgtgaacggg 332821 aggcaggacg gatggctgag aatcaagagg tatatgacgt tacgattata ggcggggggc 332881 cgatcgggct gtttactgct ttttactgcg ggatgcggga gctgaaaaca aaggtaatcg 332941 aatttttgcc gaagctcgga gggaaggtgt ctttattctt tcctgagaaa atcattcgcg 333001 atatcggcgg cataccgggg attgcgggaa agcagctgat cgagcagctg aaggagcagg 333061 cggcaacgtt tgatcctgat atcgtattga atcagcgtgt gaccgggttt gaacgcctag 333121 atgacggcac cattgttctg acgggttctg aagggaaaaa gcactataca agaactgtga 333181 ttttggcttg cggcatgggt acacttgagg tcaatgagtt tgacagcgag gatgcggccc 333241 gatatgcggg caaaaatctt cattatggag tggagaagct cgatgcgttt aaagggaaac 333301 gcgtggtgat atcaggcggc ggagatactg cggtcgattg ggctaatgag cttgaaccga 333361 ttgcggcgtc tgtgactgtc gttcatcggc gtgaggaatt cggcggaatg gaaagcagcg 333421 tgacgaaaat gaagcaatca tcggtgcggg tgcttacgcc ttatcggctg gagcagttga 333481 acggagatga agagggcatc aaaagcgtga ccgtttgtca tactgagtct ggccagagga 333541 aagacataga aattgatgag ctgatcatta atcatgggtt caaaattgat ctcgggccga 333601 tgatggagtg ggggctggag attgaagaag gaagggtgaa agctgacaga catatgcgaa 333661 cgaatcttcc gggcgtgttt gtggcgggcg acgcggcttt ttatgaaagc aagctgagat 333721 tgattgccgg cggatttacg gaaggcccga cagcggtcaa cagtgccaag gcttatctgg 333781 accctaaggc cgagaatatg gcgatgtatt ccacccatca taaaaaattg gtgcataaat 333841 aaaacagccc ttgaggaaaa gggctgcttg ccatcaggtg tgaaggagtt ttttctctgc 333901 atgttgattg tggatgaaag ctagcaattc atcctgttct tgtacggctg tgaatccata 333961 aatgccggca gctgagtcat cgcctatgca gacgatagga gggcggcttg ctgacggttc 334021 cggcaaaatg ccaatttgtt cgccaccatt gatcaattgc tgaacggaca gcttgtttgg 334081 gcaaatgacc atgtgcagcg gggattcact gatggtacgc tgaatcatgt gggtgaaccg 334141 gtcatctatg acgttttcat gagtgatata aaacgaacag gattcatgct tttgcatgtt 334201 ttccactgca tggcggctcc cgacaacaag acgtttctct gaatcaggct gaatggcggt 334261 gacaagaaag ccccgtttct caagctctgt ctttgcttgc tcagatgctg cactcagttt 334321 ggctgtcagc tggcggatgt cgattttctg agaagccagt gctctgaaaa attcacaaac 334381 cgcccggcgc gatgtgaaaa aaacgtcttc aaaggtgcca atctttcgaa gaatttcttc 334441 attgacaggc atgttttcgg tccgccattt cggccactcg atgagatcgg cgccggaatc 334501 gcgcagcttg tctgcaagcg ggtcttcatc ttcgccatga gtcacaacca tcaaatgccg 334561 tccgatgagc ggtttgcttt caaaccagct gtgtgtttga aagttgacga tgtctccgat 334621 gacgataatc gcagggtttg taatctggtg ttcctgcact ttttgctgaa tgttctcaag 334681 tgttcctttc acactccgct ggcggcccca cgttccccat tggatgacaa tgacagggac 334741 agaaggcgat ttcccgtatg aaataagctg ctggcaaata taagacaagt tcttgacacc 334801 catgtaaaaa acaagggttt gaacgcttcg ggccagccct tcccagtcaa ggttcggcgt 334861 gccttttaat gatttatcat gcgctgtaat catggcaaaa gacgatgcaa aatcccgatg 334921 cgtgacgggg atgcccgcat atagcggcgc tgcaattcca gaggtgattc ccggcaccat 334981 ttcatagcga atgccgtgct catgaagagc atctgcttcc tcgccgactc tgccgaatac 335041 gctcggatct ccgcccttca agcgaacgac ggttaaccca tttaatgctt tttcaaccag 335101 cagggcgtta atttcttttt gtttcataaa atggcggttt ggcagttttc cgcaataaat 335161 aaactggcag tccggtgatg caaattcgag cagcttcggg ttggcgagcc ggtcatataa 335221 aatcacatct gcttccttga gcgcctgttt tcctttgatg gtgagcaggc ctgggtcgcc 335281 gggtccggct cccacgaaat atacgattcc gttcttcatg atcatgtcat ccttccgtca 335341 ctgtaaaaaa tgaaggacca ctagaaaagt gatccggtct tttgatcaat atacgagata 335401 aacatgttct ccttcgatca gcgtttcata tgttttgacg catccgtggt caggttcttg 335461 gacgattccg tcttctaagg aaattttcca gtcgtgcatc gggcagaaaa catattgacc 335521 gctgacgatg ccttctgcca ggacgccgcc cttatgcgga cagcggtttt caatggcgcg 335581 gatgcttccg tctgaaagct tgaaaaccgc gagctcctta tcttcaatat acactgtttt 335641 gcctaattgt tcaggcaatt cttcaatttt tccgatacat acttttgtta cgtctttgtt 335701 taccatgtcc attcctcctc aatgatagtt tttgtcatta tgatgtggtc acgacatttt 335761 caaataattc tttagaggtt tgtttatcct ctaaaaagtc tttccacgga tccttgtgga 335821 cagagagtgt ttcattcatt cggccgttca gctcctgccg cttttccgga tcgtttaaca 335881 cggattggac atgggataaa ccgacgcgct caagccatgc ggacgtacgc tccagatagt 335941 ttgcggtttc cctgtaatat tgcaggtaag cgcccgcgta ttctaagact tcttcatttg 336001 ttttcacctt catcagcaaa tcgccggcac gcaaatgggt tccgccgttt ccgccgacat 336061 aaagctccca gcctccgtcg atgccgacaa cgccaaggtc cttaatgccg gattccgcac 336121 agtttcgcgg gcaggcagac acggccattt tgactttgtg aggcgtgttc agcccttcga 336181 attttttctc aagcgcaatg cccagtgcca tggagtcttg tgtgccgaag cggcagaatt 336241 gctcgcctac acatgttttc actgtgcgga gcgtttttcc gtacgcgtag cccgatggca 336301 tatcaagatc ttcccatacc ttcggaaggt cttctttttt cacgccgata agatcaattc 336361 gctggccgcc tgtcattttc acgagcggga tctcatattt gtcaacgaca tcggcgatct 336421 tgcgcaaatc tgtggagttg gtcacgccgc cgtacatccg aggaacgact gagtatgttc 336481 cgtctttttg aatattggcg tgcattcgtt cattaacaaa gcgggatgtc cggtcatcct 336541 cgtatttggt tggattgatc atgcctaagt agtagttcag agcgggtcgg catttagaac 336601 agccttctgg cgttttccag ccgagcacat tcatgacttc tcttgtatgt gacagccctt 336661 tggctttgat ttcttctacg acttcatctc tcgacaatgt ggtgcagccg caaatggctt 336721 ctttttgcgc tgacgcatca aagtctgatc cgagcgtatg ctggaggatt tcttctacga 336781 gcggcttaca gcctccgcat gagcgggatg cgccggtgca tgctttgatt tcgtccgttg 336841 acgagcagcc cttttcctgt atggcttgaa taatcgcacc ttttgacacg ccgttacagc 336901 cgcagatgat ttcatcgtcg ctcatcgctg cggttatgct tgtgcctgct tcctggctga 336961 ggggctgtaa gattgatatt ttagaggttt cagagatatc ggcttctttt tgaatcatag 337021 aaaacaggcg attgccttcg ctgctgtcgc cgaataaaac agcaccgaca atttgattgc 337081 ctctcaggac aattttttta tagatgccgt cctgctcatc gaagacttta atcgcttttt 337141 tctcctctga ttcgttaaag tcaccggcag agaagacctc gacgcctgat acctttaact 337201 gtgtggagag aacggagccc tcatacggtt ttgtttcgat gccgcacata tgctttgcca 337261 gcacttttgc ctgttcatac agcggcgcca caagcccgta ggcgattcct cggtgctcgg 337321 cacattcgcc gaccgcgtaa atgtgcggga tttcagtctg catataatcg ttgacgatga 337381 tgccgcggtt aaccggaatg ccgctctcgg ccccgagcgt tgtatttggg cggatgccga 337441 cagccatgac gactaaatca gcttcaatgc ttgtgccatc cttgaatcgg aggccttcga 337501 cacggtcgtc accgacaatt tcttctgttt gcttttcaag taaaaaggtc ataccttgtt 337561 tttctaactc gttttgcagc aggcgtcctg ccgttgcatc aagctggcgc tccatcagga 337621 atggggcaag gtggatgacg gacacgtcca tgccgagatt cagcagtccg cgagctgctt 337681 ccaaaccaag tagtcctccg ccgatgacgg cagctttttt atattgtttt gacgcggcga 337741 gcattgtgtc tgtatctttt atgtcccgga aagctgtgac gccttttttg tctgcgcccg 337801 gaatcggaag gataaaaggg accgatcctg tcgccaggat caattcatcg taaggctgga 337861 ttctgtctgc atctgtgatg actgttttgt tttccgtgtc cactttgatg actgtttcat 337921 ttgtatacaa ttgaatgttg ttttcttcgt accagtccca atcgtttaac gtaatatctt 337981 taatatctgt atcgccttga agcacttttg acaaaaggat tcggttgtaa ttgggatgcg 338041 gttcggcacc gaaaattgtg atctgaaact cgtctttagc aacactcagt atctcttcaa 338101 tggcccttac cccggccatt ccattaccaa caagaactag ctgttttttt cccatcagat 338161 gatccgctcc ttatcaaatg ttttttccag cgtagcacag caaaaaggaa tatttaagat 338221 acatgttata aaatgtaaca aaatatacga aaagttctaa aaattttatg aaaaatttaa 338281 ataggtatga ttcggacggc gcatacctta aaaccgggca ttttacaggc tggatctaag 338341 gcttccccga ttaaatcatt cacattttga gcgtctgccc aatggatggg aacaaaaacg 338401 gtatcttttc tgatttgttc tgataatttg ctgcggacgg tgatgcttcc ccgcggcgat 338461 tctattttta ccagtacacg gtcctcgata ttgtaggtcg ctgctgtttg cggatggatc 338521 tccataaacg attcaaaatg tctcgcggca agggcggcgc tttttcttgt ttggacgcct 338581 gttaagtagt gagacatgac tctgcctgtc gttaaataaa gcggataatc ggctgtcggc 338641 ttctcttttg gaacaggtgg ttcgtttgga atcacactta atgccgcttt ttgatccgga 338701 tgagcaaatg attctgtaaa caagcgccca gttccgggat gatcagattc cggacacggc 338761 caatgaatgc cgccttcacg tctgagcctg ccgtatgaga tgcctgaata atcggcaatc 338821 ccgcctcggc tcgcttctct caattcattg aaaatatcct ccgctgacgt ataagaaaag 338881 tagcggccct tgccgagagc ggatgcgaga tcacaaatga tctgccaatc atgctttgct 338941 tcgccggggc atggccggct tgcttctctt aatgtcacgc gtccttctac atttgtcatg 339001 gtgccttcat cttctaagta agaggaggca ggtaaaatca catctgcgta tttcgcagtc 339061 tcagaaataa acaaatcgat tgcgacaaag aatgtcagtc ttcttaaagc ctttttcacg 339121 agatttgcat ttggactgga aacagcaggg ttggagcaca tgaggaacag tcctttgatg 339181 tcgccgtcat tgattttttc catcatttca taggctgaga caccttttcg cgggagttca 339241 tcctgatgga ttccccacac tttcgcaata tgcgcccggt gttcttcgtt ttcgatagaa 339301 cggtagcctg gaagctgatc ggctttttgg ccatgctctc tggcgccttg cccgttgcct 339361 tgtccggtga tcgccccgta gcccgagtaa ggtttgccga tttttcctgt gatcagcacc 339421 atgtttaaga agcctttcac agccgctgtt ccatcggttt gctgttcaat cccgcgggct 339481 gtaaacagca tgccggacgt ttccttggca aacttcacag cagcttttct tatatccacc 339541 agcgagacac tcgtctgttc ggcgatgtca ttcaggtcca acgagtcagt atgctgcttc 339601 agctcttcga atccatttgt tcgtgattga atgaaatcct cgtttataag ctgttcgtca 339661 atgatgattt tgacgagacc gttggcaagg gcggcgtctg tgccgggttt gattttcaga 339721 tgaagatcgg cgattttcgt tgtcgctgtt tcacgaggat caatggcaat gaagtaagct 339781 ccgttttctt tcgctttttc aaaatacggc ataatcgtag gctggcattc cgcaatattg 339841 gtgccggcca gaatgatcac acgggtgtgg gggatgtctg ataaaggatt cgttaagcct 339901 ctgtccgcgc cgaatgtttg gttggctgcg gtggctgctg cggacataca aagtctcccg 339961 ttgtagtcga tgtattttgt ctgtaagcct actcgtgcga acttccctaa caaatacgcc 340021 tcttcatttg taatcgaggc gcttccgtat accgccatgg cgtcatgtcc gtgttcagtt 340081 tggatcattg tcacttggtc tttgatatga ttcagtgctt cttcccagga aacaggcata 340141 aactcgccgt ttttcttcag cagcggccgg gtgatgcggg aggagttcaa ggcatgctgg 340201 tgagcattca tgcccttgat gcatagccga ccctgtgtcg taggattatc aatcccgatc 340261 gcagtgtact ttttgcgcgt gacgatggtt tgttccacga gctgcatttt gcactgcatg 340321 ctgcaaaacg ggcattgagt gtcatatgtt ttttctgatt ggacgtcttg ctgtttatca 340381 cggaaatatc taagcagtcg ttcagtcaaa atgcctcatc ctttcttata tgcgcccgtc 340441 tctacagtcg ggttttgaat cagtgacaga tctgtttgga ggctttccag cagctgtgcc 340501 cttaggtctt cttcgaatag cacttctctg atatgaacga tcccgagacg gtctatccac 340561 tgatgaacac cttctaagta atgagccgtt tcccgataat actggatcag tcctttgatc 340621 atgccggcag tgctgtcttc gttctcagtc acgcaaaaca aagctcctga acgggcatga 340681 gttccccgga cgccgccgat gtgaatgtcc cagccagctt gtgtccgaat tgcgccgaca 340741 tcttgcaggg cggcctcggt gcagtctgtt tcacatgata agctgataga aatgggagcg 340801 ggtaagggaa gcatctcaag ttgtctttcg atttgggctg ccagctgctg aatcgatcga 340861 ttttgcccgc atgtacatgc tttgatgctt tgcagcgcgt gtcggtgttc attagtgtaa 340921 acgggcattt tcaggtcttt tttcatgttc gggagatccg caggcttgat cccggaaagc 340981 ttcagccttt ggccgtgagt gatggatacg tcgggaatgc tgtatgcctc aatgatgttg 341041 gcgatggttc ttagctgctc cgcgtttgtc cgcccgccgt acatttgcgg aatcaggatg 341101 catgtctctt cagtggctgg ctcaggctgg acaaacccag ggtacagcat ttccagatag 341161 tattgaatcg caggaacaca agtactgcat ccgttttttg ttttccagtc aagctggttc 341221 atcacttctg ccggattagt gaatggcctg cgctgaagct cagcgatgat gtcgtcttct 341281 gtaaaatcag tacagctgca aaacgaaggt gtgctggcgg gcttcgtata ttcgctgttg 341341 gtcatgtatc tcaaaaggtc ttcaacgagc ggtttgcatc ctccgcagga cccagtggct 341401 ttggtgcagt gcttgacttc ctcaacagtt gttaagctat tcgtgtgcac cgcgtcttca 341461 atcgcgcctt tcgtcactgt gttgcattgg caaatcgttt cactggaagg catggattca 341521 aataaagggc cgcttgtctc cggttcgatg atctgttttt tggcaatgga gatgtctcgt 341581 tgtttaagca ggctgtcgag aagccgctgc ttgtcacggg tgtctccgaa taaaataacg 341641 ccggccagtt tgtcatctac aaaaagcgct tttttataaa cgcctgcttg ttcgtcgtag 341701 attttgatgc tcgtcgtgcg ttcatcctct tggatctttc ctgctgacca cacatcgatt 341761 ccagctattt ttaacgccgc agatggtgct gagccttgat attcctcaca tggaacgccg 341821 caaatatgac tggcgagcgc ttttccctgc tcataaagcg gagccaccaa tccgtacacc 341881 gttccgttat gctcagcgca ttcaccaacg gcgtagatat tcggttcgct tgtctgcatg 341941 aagtcattca cgatgatccc gcggttcact ttgattccag cggatacagc caattcaata 342001 ttcggtttga cgccggccgc catcacaatc aagtctgctt ttaatgaaga gccatcttta 342061 aaatggattc ggtctgcctt cgtggcgccg gaaatggaga cggtgtcttt ctccaaaaga 342121 aaggttaggc ctttttgttc cagctctgtt tgcagcagcc gcgccgctgt ttgatcgagc 342181 tgtttttgca taatgccggc ggagtggtga atgacgctga catccatacc gagatgctgt 342241 aaacctactg cagcttccag tcctaataag ccggctccga ttaccgcagc cttttgaaag 342301 tgctgggcca tgttcatcag cgcttggcag tcttctattg tccgaaatcc atagacacct 342361 tttttgtctg ccccggggat agggagaata tgaggggagg agcctgttgc cactattaat 342421 ttgtcatacg acagagtgcg tttccgatct gtgatgacct gctgctgatc tgtatcaatc 342481 tgaataaccg tttcgcctgt gtaaagcgtg atcccgtgct tgtcgtacca atccttgctg 342541 ttcagtgtaa tatcatcgag tgacgcttca ccctgcaata cagaggataa gagaatgcga 342601 ttgtaattgg gatgcggctc gcttccgaaa atgacaatct caaacatgtg gcgattcagc 342661 tttaatactt cttcaataca gcggattccg gccatgccgt ttcccgctaa cactaatctt 342721 tgtttcttca tgtatcagac ctcctttggc gaagctcgta agttttctcc tattaaaaat 342781 tatgtcacaa tgcattgtta acgcattaaa cgtgtcacaa aaacttacac atgtcttttc 342841 cagaaaataa tggtcctata tccttgattc agaaaatgta aaataatgag ggtctagaaa 342901 ggggaatctt atgaagctgt cggaactgaa aactagcggt catccactca ctttgctctg 342961 ttccttttta tactttgatg tcagttttat gatatgggtt atgcttgggg cgctgggtgt 343021 ttatatttct caggattttg gcctgtctcc ttttgagaaa gggcttgtcg tagctgtgcc 343081 gattttatct ggatctgtgt ttcgtatcat tcttggtatt ttaacggaca gaatcggacc 343141 gaaaaaaacg gcagtgatcg ggatgctggt gacgatgatt ccgctgcttt gggggacatt 343201 cggcggccgt tccctgactg agctgtatgc catcgggatt ctgcttggcg tggcgggagc 343261 aagctttgct gtagcgctgc ctatggccag ccgctggtat ccgcctcatt tgcagggact 343321 tgcgatgggg attgccggag cggggaacag cggcacgttg tttgcaaccc tgtttggccc 343381 tcgtctggca gagcagttcg gctggcacat tgtcatggga attgcgctaa ttccattatt 343441 gatcgtcttt attctttttg tatccatggc aaaggattcc cctgcacagc cgtctcccca 343501 gccgctcaaa agctatctgc atgtgtttgg gcaaaaggaa acatggtttt tctgcctgct 343561 gtacagcgtc acatttggcg gatttgtcgg gctctcaagc tttttatcta ttttctttgt 343621 tgatcaatac cagctgtcaa aaattcacgc aggggacttc gttacattat gtgtggcggc 343681 ggggagcttt ttccggcctg tcgggggctt gatttcagat cgtgtcggcg gcacgaaagt 343741 tctttctgta ttgtttgtca tcgtggcact gtgtatggcc ggagtcagta gcctgccatc 343801 tctctcaatg gttattgttc tattgtttgt cggaatgatg gggctcggaa tgggaaacgg 343861 cgcagtattc cagctcgtgc cgcagcgctt ccgcaaagaa atcggcatgg tgacgggaat 343921 cgtcggtgcg gccggaggaa tcggagggtt tttcttgccg aacatcttag gatctctcaa 343981 acagatgaca ggcacatatg ctatcggttt tatcacgttt tcctgtatcg cgctgctggc 344041 gtttgcactt gtgcttgccg caggctatta ctggcggaaa agctggagcg cggaaagcag 344101 cccggcggat gtttaggatt ttgacggaca cgcgtttgtg cgtgtctttt ttattttctc 344161 ttgattttca acagtgaacc gatcaaaata aatagtaatt attacgattt gttagtgaga 344221 ggagttttct gaatgaatca acatacgctg ctcccgaaaa aaacggagcg tcttcaatac 344281 tttggatcgg tcagtccgat caaaggcgag aaaccagtgg aaaaagagaa aatgaaggac 344341 ctgcaaaata tcaggaagga ttattttttt gacattcagc atgtaggtgt agctaatgtg 344401 tcccatccag tcacaatcac ttctgccatg atgcctgccg agcaaacaac ggctgcgaac 344461 tttacaatga cttgtaattt gccgagaaat cagaagggga ttaacatgag ccggttaaca 344521 gagctgctgc aagtctatca tcaaaatggc tggattctct cattttcctc tcttcagcaa 344581 tttacgaaag agcttgcaga aaacatggac acatcatctg ccacagttga agtgaggttt 344641 ccgtggtttt tcgaacggaa aagcccgaag cttgagaaag cgggtttgat gcatgctgat 344701 atattcatgt ctgtcaccta tcgcaaagat cagccgttta aacagcgtgc cggcatctca 344761 gcaaaagtaa cgactctgtg cccttgctcc aaggaaatca gcgaatacag tgcccataat 344821 cagaggggaa cggtcagcat ttgggcggat attcacccgg ccgcatcgct gccaagtgat 344881 gttaaagctg atttgcttca cgccgcagaa tcaaatgctt ctgcgagact gcatccggta 344941 ttgaagcggc ctgatgaaaa agccgtgaca gaaacggcct atgaaaaccc gagatttgtt 345001 gaggatctcg cccggctgat tgctgcagat ttgtttgagc ttgaatgggt gtcagccttt 345061 gagattgaat gccgaaatga agaatcgatc catcttcacg atgcctatgc gaagctgtgt 345121 ttttcgaagg aagtggataa aatatgaaac tctcattatt cattattgca gttcttatgc 345181 cagtcatcct gctgtcagcc tgctccgatc atgcagaaga acacgcaagt atcaatacaa 345241 agaaaacggt cgaaaacata acggacgttc gaaaaacagc aaaaacaagc attgattgga 345301 caaagccttc gggcggagaa tacccggata ttaaacagaa gcatgtctgg attgatgtga 345361 atgtgaagga gcagaaggct tacatcaagg aaggaagcaa caccatctat acaatgatga 345421 tttcttctgg tcttgatcaa acaaaagatg atgctacgcc aaagggcacc ttttatgtag 345481 agcctgaacg gggagaatgg tttttctccg aaggatacca ggaaggcgca gaatactggg 345541 tatcatggaa aaatcacggt gaatttttat ttcatagtgt gccaatgact aaggatcaaa 345601 aagtcatcaa aacggaagca gaaaaactag gaacgaaagc atctcacgga tgtatcaggc 345661 tgaccattcc agatgcgaaa tgggtatatg aaaatatccc tgaacataca aaagtggtga 345721 tcagctgaat tgaaaaccgt tgacaaaaag gaaaaaagac catacaattt aaatcgtaac 345781 aattacgttt tatgataaat ggcttatcat tgtctgtgca tctgtgaaaa gcggaaaggc 345841 atcgattaag gatcttgctg tcggcaaagg caaggatttg cgatggggaa aaggattaaa 345901 cgcggttgga gtctttactg atttagaaat cgggcggcag cgagaaatga gcgcgaaaag 345961 ctgctctaca ccattgtaca tacggcgaag tattcaattt aaatcgtaat cattctattt 346021 taatggaggc actattatga aaaaaattcc ggttaccgta ctgagcggtt atctcggtgc 346081 gggaaaaaca acattgctga acagcatttt gcaaaatcgc gaaggcttga aaatagcggt 346141 tatcgtaaac gatatgagcg aggtgaacat tgacgcgggc ttggttaagc aggaaggtgg 346201 cctttccaga acagatgaaa agcttgtgga aatgtcaaat ggctgcattt gctgcacgct 346261 tcgcgaagac ttattaattg aagttgagaa gctggcaaaa gacggacggt ttgattatat 346321 cgtcatcgaa tcgacaggaa tcagcgaacc gatcccggtg gcccagactt tctcttatat 346381 cgatgaagag atgggaatcg atcttacaaa attctgtcag ctggatacga tggtgacggt 346441 tgttgatgcc aaccgttttt ggcatgatta tcagtcaggc gaaagccttc tggaccgcaa 346501 agaagcattg ggggaaaagg atgaaagaga aatcgccgac ctcttgatcg atcaaattga 346561 gttttgcgat gtactgatct taaataaatg tgatttggtc agcgagcaag agctcgaaca 346621 gcttgaaaac gttcttcgta aactgcagcc aagagccagg ttcattcgtt ccgtcaaagg 346681 aaatgtaaaa ccgcaggaga ttttgcatac agggttattt aacttcgagg aagcgagcgg 346741 atcggccggc tggattcaag agctgacggc aggccatgcg gaacacaccc cggaaacaga 346801 agaatacggt atctcttcat ttgtatataa gagacgtttg ccgtttcatt ctacacgatt 346861 ttaccgttgg ttggatcaaa tgccaaagaa cgtggtacgt gccaaaggaa tcgtctggtg 346921 cgcatctcat aacaacctcg ctttgctgat gtcgcaagca ggtccgtcgg ttacgattga 346981 gcctgtatct tattgggtgg cggcgttgcc gaagcttgag caggagcaag tcaaacagca 347041 ggagccggaa atcctggagg agtgggaccc ggagttcggc gaccgcctaa cgcagctagt 347101 ttttatcgga actgacctgg atgaagaaac gatcacgaaa gagcttgatc aatgcctgtt 347161 gactgagtat gaatttgatt ccgactggtc gctgtttgag gacccgttta aatggaagct 347221 gaatcaatag aaaaaaagcc gtcccatggg gaacggcttt ttttaatgaa acgtttgttt 347281 aaacataatg agcgtatttt ttctcaagga tattctgaaa gaccgcggca atggagcaga 347341 tggcccaata aatgagagcg gtcagaatat acatggtcat ataatcaaac tctctgcccc 347401 cgatgatttt cgcatgctgg agcaattccg gcactgtaat catcgcagcg agagaggacg 347461 ccttgatcaa gtcgagcaat acattggcaa gcggaggcag cgcaatacgt atcgattgcg 347521 gcaaaatgat gcccctcatc gtctgccaat aggaaagacc cagcgaggat gcggcttccc 347581 actgtccttt ttcgacggat gaaatggctg aacggttaat ttccgcaatg taggcggcgc 347641 tgtttaggct aaagccgatt aaagcagccg tgacagcgga aaattcaatg ccgatataag 347701 gaaacccgaa ataaaggata aacaaaatca ccaaaatcgg aacgcctcgc ataaatgaga 347761 tatagagctt cgccggccat cttaacaaag caagtttaga cattctggcg agtgatatga 347821 acaggccgat cacagttccc gcaaacatgc ttacaaaaga gatgagcagt gtataaccaa 347881 tgccttttat gacataaggg aacgattcaa tggccagctt cgtgttgaaa atatattccc 347941 actgaatgct attgatcatg gcgtccgatt acaaatcaac gtcctgaacg tcggcatcaa 348001 ttttttttga tacatctgct ttattgaaga attgtttcga cagtttagtc aaagagccat 348061 ccttgctcat ctctttcaat gcttcgttca tctttttctg aagtgccgca ttgctttttt 348121 tcatgacaag ggcctgtttg ttcggcatgt acttgatgtc aggatgaatt gtaatgttga 348181 gatccgggaa tgccgcgagc gcaagtgtct gcaggtaata gtcgtttaaa atgacgtcag 348241 tgcgtccgtt ggcaacatct tttaaatatt gctcattcgt cgcattatca taaatcactt 348301 ctttggcgcc gtattttctc gcgacctcca tgtagacggt tgtagccgcg ccagccgctt 348361 tcttcccttt taaatccttg agcgttttaa tccctgataa atcgtctttt cggacaattg 348421 ccgtgccgta tgaatattta tatggagtgg aaaatgcgaa cttctcctca cggtccttcg 348481 tcacatcgat gtcattcgcg gctgcgtcaa cctgtccgct gttcaccgct gtcagcatcc 348541 cgtcaatgcc catctccttg aactcaacct tcagccccaa gcgttttgcc gcttcacgaa 348601 caacttcaac ctcgtagccc gtcagcttat cagagccaga gtcagtatcg tgataagaag 348661 tgggatagag cgtacctgat gtagcgacta cgattttccc tttatcctta atctgctccc 348721 agcctgtatc cttggaatcg gcttcatttt tgccggaaca ggctgccaat ataagaaaga 348781 aagccattgt gaaactgaat ataacggctt tggaatgcat gaatgatttc acctatagtt 348841 cccccaatct gttaatcaac taaaaagata gcattgaaca taaggggttg caatatgttg 348901 atcgcgtttt caaaaagttc gaattgtgta tacaaaaagc atgggtgggt gtttaaaagc 348961 gtctatgaag ggaagaggtg atgaaaaaag gaattgtcca aggatgaatg ccagacgtac 349021 caaggaaacg catgtgaaag tgaaggatgc agcagacccg tcactcatct atgccaatac 349081 cggaagaaat ggtcaagagg catgaaaccg atcttcagaa taaatttaag tcttgctgat 349141 gcccctaagg catatgatat attcgatgag aaagaaaatg gaaacattta aaccataatg 349201 gggagtcaaa tgaatattta caaaccagcc ggattttgga tcagacttgg agctgcattg 349261 ttagactaca ttatagtctc cgtgccgctt ttgctgatct attggctgat tacaggaaaa 349321 gacccaaacg acagcatgtt catcagtttg gttgttctgc tgtattctat tttgctgccg 349381 atgttttggc gcggttatct tatcggaaaa aggatctgcg gaatcagaat cgtaaaaaaa 349441 gacggatcac aggtcagtct gttaacaatg tttttacggg ttattgtagc cggcctggtt 349501 tactgtataa ccttcggact cggcttgatc gccagcctga ttctgattgc cgtacgagaa 349561 gacaaacgga ccctgcatga tttaatcgcg ggaacatatg tcacttatgc gacaccaggt 349621 gaagaggaac ttaatgctga cgaagagatt agaaagagcg aataatggtt cgctcttttt 349681 atttttatgc ataaaaaata caaggcagca aaacatatga aaaataggat tggaggaata 349741 aaatggatga aacgaataac catcaacatt atcacaatgt tcattgcagc ggctgtcatt 349801 tctctgaccg gtacagctga ggccgctgaa aaacagcagc agtctcccgc aaatgttaca 349861 ctgacagatc agcaaaagaa agagattgaa caactggaag cagagattct taaaaagcgc 349921 aaagacgtga tctcaaagta tgtacaatac ggtatcctgc ctaaagaaag aggagaacac 349981 atcaaaaatc acttggacaa acactttgaa atgatgaaac aaaacggctt tgttccaaag 350041 caccatcctc atccgcataa atttgaaaaa agacattaag attttaagca tccaatggga 350101 attgggtgct tttgcgttat ttacaggtag gcaatattag ctgagctgtt ccgcgactaa 350161 catcgagttg atatgaaacg cgtttcatag cctatgatag gtttatcaaa taattcagga 350221 gtgataaaca ctatgatcca ccagcatcca gaatcttttc cgaaacattt tttgtggggc 350281 tctgcttctg cagcgtacca gattgaaggc gcttggaatg aagatggcaa aggcccttct 350341 gtttgggatg tgtttacgaa aataccgggc aaaacgttta aaggaaccaa tggcgagatt 350401 gcggttgacc attatcaccg atttaaagaa gatgtcgctc tgatggctga gatggggtta 350461 aaagcatatc gattttccgt cagctggcca cgggtttttc caaaaggaaa aggagagatc 350521 aatgaagcag gtctagcgtt ttacgatagt ctgattgatg aattgctttc tcatcacatc 350581 gagccggttc tgactttata tcactgggat ttgcctcaag cgcttatgga cgaatacggc 350641 gggtttgaat ccagaaacat catagaggat tttaatcact actgtattac tctttataaa 350701 cgttttggag acagggtgaa atattgggtt acgttaaacg aacagaacta caattttaat 350761 cacggattta ttacagccat gcatccgcct ggagtgaaag acagaaaacg attttacgaa 350821 gcaaaccata ttgcgtttct ggctaatgca aaagccatcg aatcatttag agaatatgtg 350881 cctgaaggca aaataggtcc tagctttgct tattctccgg cttacccttt atcaagtcat 350941 ccagaggata tactggcatt tgaaaacgcc gaagaattta cgaacaattg gtggcttgac 351001 atgtattgct ggggaaccta cccgcaaatt ccattccgct gcttggaaaa acagggatgg 351061 gcgccgacaa ttgaagcagg agatatggac ctgctcgcca aagggaagcc tgattttgta 351121 ggtgtcaatt attatcagac gatcacctat gaacgaaatc cgcttgatgg tgtgtcagaa 351181 gggaaaatga atacgacagg ccaaaaggga accaatcagg agacggggat acccggagtg 351241 ttcaaaacga aaaaaaatcc gcatctgaca acgagcaact gggattggac aattgaccca 351301 attgggctgc gtatcggtct tcgccgaatt acaagccgct atcagcttcc agtgtttata 351361 acagagaacg gtttgggtga atttgataaa gttgaggacg gcactgtaca ggatgattat 351421 cgaattgatt atttgcgttc gcatcttgag caatgcagac aagccatcag tgacggtgtc 351481 gatttaatcg gctattgcag ctggtcgttt actgatctgt taagctggct gaacggctac 351541 caaaaaagat acggatttgt atatgtcaat cgtgatgaag aaagcacatc cgatttaaaa 351601 cgcttgaaga aaaaaagctt ttattggtat caagatgtca tcaagacaaa cggagaaagt 351661 ttataaagag tccctgagag ttattctctc aggggttttt cattacacag aaacagcatc 351721 aataatataa gtgtcggcgt gcaaatctga catttcagcc ggcacagtcc agcatgtcaa 351781 ttgatagtct cctttaggca gatcaaagga cagtctttta gacatgatgc tttcaatatg 351841 aattccgttt tctgtgacat gaaaaggaac agtcactttt ttttcgtagg agtttactgt 351901 ttctgaactg ttcaggcgaa aaagaataaa ggcctttgta tttcgctgtg cctcaaagga 351961 aatggctccg tctgccgcag catatccttt ttcaatcgct tcgtcagtcc aatccattac 352021 aggaggtgta gaatcctttt gaaatacagt aaattgatga tatgaaatcg aaagttcttg 352081 cggcttccat gatttgatca atgtgctgtt cctcctctat gtactgttta ctgaattgtg 352141 aataaaacct ttgtgccgtc tgggtaatcg gtaagccgat gcccgaccca agagcctgct 352201 ccgcggttgt cagcgggaga aatgtattct acagaagctc cctcaccgcc ttctttgcac 352261 atggccattg gccattcatc tctgtcatac ccctttttgg aaggtacgtc ctttaatgat 352321 tgctcgcggc gttcttcagc tccgtctctg tcaatagtgc acacctctga gtgcccctca 352381 tttatcgcat ccttaatatg cttggcagtt tcgggatacc ggtcagatgg gaaggccatt 352441 gtttcatcat attctttcgt ttgagacgtt ttttgatcag ctgagaaaaa gtctcctttt 352501 atcaggccga cagctgcagc tgctatgatg acgatgacga gaagtatcgt ttttatgatg 352561 tccgtcgtga tgttcacctc ccgcttttaa aactgacaca agagtaatcc agaaagcatt 352621 tggtgtaaag gtttaaattt tatgttttac gatcagttta ttgcagaaat cgtaatttta 352681 gcagatcgaa atatttgttt tcagcaaaat acgattgcca atttacaata atgatagtaa 352741 gtcatcagcc gttttcggct tgattaatca ttttaaattg gcttatgata ccggtaagct 352801 cctcagctaa ttgagaaagt gtttcagaag ctgcggtaat ctcctccatt gcagcaaatt 352861 gctcctctgt taatgcagcc gcttgccggg tatttttagt agattcttta atgtcggccg 352921 tattggctgc aaaggaatca tttatttgat gtgcactggc tgaaatgttt gttacagatg 352981 ctgataaatc actaatctcg gcgctgattt cacctgttgc agctgcaatt tccttaaatg 353041 catctctggt gcgctggatc atggtgactc cttctgcagc ttctgttttc acatgctcaa 353101 cagatcttgc agaccggttc atatcctttt gtatttctat gatcagtttt gaaatctgcc 353161 ccgcagactg ttgagactct tctgctaatt tccgtacttc atcagcaaca acagcaaagc 353221 cttttccttg ttcaccggct ctggcagctt caatcgctgc attcagcgca agcaggtttg 353281 tctgatcagc aatttgggtg atgaccgata aaatttgctc aatttgttta gagcggccgt 353341 ctaactggtg tatgatttct ccgcttttct gaattgactg gtgaatcgca tccatttgcg 353401 cctgtacatt tgcaatttcc ttttgtccaa tgtctgcttt tgattgagcg agctgccctt 353461 tgtcagcgat agcggcagta tttgcagaaa tatcccggat gtctgctgaa gcttgtttta 353521 atgagctttc actattttca attcgggtga tctgatcttg ggctccattt gcaatctgct 353581 gtacagcttc tgtgattttt tctgaagctt gatttgtttc ctctgctccg gctgagagct 353641 gctgagaggc tgacgcaagc tgaagggctg attgttgtac ggtttgtatg gtatcgttca 353701 gcttcattct catcttatta taatagacgc ttagttctga aagctcgtca ccggttttgt 353761 ctgacacctc tattgtcata tctccgtttc cggcactttc aaaggcgctt tttaaagcgt 353821 tcagccgctt gttgattttt ctggtgaaaa ccaagacaag gatgactgat accataatga 353881 cgataacaag aacgatagcg aattgagtga aaagtgattg tgtaagtgat gctaaaatac 353941 tttgattagc tccggtatac agcatgccga tgatgttccc attttgatct tttaacggca 354001 tgtatgcagt ctgataagaa gaacctgcta catctgcttg tccgtaaaaa cgctttcctt 354061 tctttaaaac agcggcaata acttcagaag aagcctgggt gccgacggct ctttcgccat 354121 ttttcatgac attggttgca acacgagtat cgccttggaa aatggtaatg gtatcacctg 354181 tcttttcacc aagcagatca acaatatctt catttccatt gatttgtgtt tgccctttat 354241 agagcttatt gtttttcacc tgccagtcgc ctgacatgac atcatcaata taagtgctgc 354301 ttaaagcgag atcacctttc gctttttcag ttgccatttg tttcatgctt tctgtaattt 354361 ccttaagcat cacagtgcca actgatgccg aaaacaaaag aatcaccacg aaaacgaggc 354421 aaagaatttt agttcctagc ttcatcttaa atcgttttat caacataatt cctcccttta 354481 cgatttgcag gtcatattac ttatcgggtt tttgggttta aagttttatt ttagaaaaaa 354541 taaaaccggc ctgatcttca ggccggttgt gtgatgctat tcaaggtttg cgtggtgagt 354601 gaacatagtt tcagaatcga gacctttttt ctccatgagt tttaaaatca ctgcatcata 354661 gaagagcagc aaagtttgtt caaataatga tcccattggc tgaatggttt tatagcttcc 354721 gttagactgg tctttagggg aaccaggcat tctgatgatg aggtccgctt gttttccgat 354781 gcttgattcc ggattgatgg ttaaagcggc aacaattccg tgtaagcttt ttgcttttgc 354841 tgcggtatga atcaagctct ttgtctcgcc tgatcctgag ccgataataa ctagatctcc 354901 ttcggcgagc ggcggagtga gaatctcacc tactatatgg gcgttgaagc ccatgtgcat 354961 cagtctcatc gcgaaggatt ttgccatcag gccagaccgc cccgcacccg cggtgaaaat 355021 ttggtgggat gaaagaatgt gatcggcaag ctggtcagct tcttcattag aaatataagc 355081 tgctgaattg tgtaactcat tgagaatttc cgctacgtat tcagtcgttt tcatcggagt 355141 tatccttgga caatcagctg cttcattttt gaagctgttt ccgccttatc agctgcgctt 355201 gtaattccgc ccccgacaat gacaaggtca ggcttttgct ggatcacttc tggcagtgta 355261 tcaagtttga tgccgcccgc gattgcggtt tttgcgtttt ttacggtatt tttgattgtc 355321 gttaattctt cgaaagagtt tttgccctct gcttgaagat catagccagt gtggacgcag 355381 atgtagtcaa caccgagtgc gtcaatttct ttcgcacggg attcgatatc tttcacgtta 355441 atcatgtcca ctaagatttt cttcttttgt tttttggctt cttctactgc gcctttaatc 355501 gttgcatcgt ctgtagcccc taaaacggtg atgatgtcag cgcctgcttc cgacgctttc 355561 ataatttcgt agcctccggc atccatgatt ttcaggtctg caagaacctt caattgagga 355621 aatgcttctt ttatttcttt aacggctctt aggccttcat tgatgacgac cggtgttccg 355681 atttcaacta cgtcgatgta ttgttctacc tctttgacaa gctcaatggc ttccgggatg 355741 ttgacgaggt ctaatgcaag ctgtaattcc attgttgatc cactcccttt ttcgaattat 355801 tgttcattct ataggttcct tcttttgttg agaagtaggc actttgaagt caacaagtta 355861 cttggaggat actgtgagga gagacaatca gatttctttc gcttgatttt atgagtgagt 355921 ataatgaaaa aagagtctgc aaaaaagtaa gtaagtgatg atacgtatct aacatacaaa 355981 aaggttacta agggggggga ttctattgag ccggatggac gacaaaaggt ttaattgtga 356041 gaaggaatta acgcttgcag tgattggcgg taaatggaaa atgctcattt tatggcattt 356101 aggaaaagaa ggcacaaaac ggttcaatga attaaaaaca ttgattcctg atattacgca 356161 gaagatcctc gtgaatcagc tgagagagct tgagcaggat atgattgttc acagggaagt 356221 gtatccagtt gtcccgccga aggttgaata ttctctgacc ccgcacggag aaagcctcat 356281 gcctattctt gaagccatgt atgagtgggg gaaaggctat atggaattga ttgatatcga 356341 caaaaatgtc atgaaagaat cgttgtaaga cgctcttcgc aagggtgtct ttttttgcct 356401 ttttttcggt ttttgcgcgg tacacatagt catgtaaaga ttgtaaattg cattcagcaa 356461 taaaaaaaga ttgaacgcag cagtttggtt taaaaatttt tatttttctg taaataatgt 356521 ttagtggaaa tgattgcggc atcccgcaaa aaatattgct gtaaataaac tggaatcttt 356581 cggcatcccg catgaaactt ttcacccatt tttcggtgat aaaaacattt ttttcattta 356641 aactgaacgg tagaaagata aaaaatattg aaaacaatga ataaatagcc aaaattggtt 356701 tcttattagg gtggggtctt gcggtcttta tccgcttatg ttaaacgccg caatgctgac 356761 tgacggcagc ctgctttaat agcggccatc tgttttttga ttggaagcac tgctttttaa 356821 gtgtagtact ttgggctatt tcggctgtta gttcataaga attaaaagct gatatggata 356881 agaaagagaa aatgcgttgc acatgttcac tgcttataaa gattagggga ggtatgacaa 356941 tatggaaata actttttacc ctttaacgga tgcacaaaaa cgaatttggt acacagaaaa 357001 attttatcct cacacgagca tttcaaatct tgcggggatt ggtaagctgg tttcagctga 357061 tgcgattgat tatgtgcttg ttgagcaggc gattcaagag tttattcgca gaaatgacgc 357121 catgcgcctt cggttgcggc tagatgaaaa cggggagcct gttcaatata ttagcgagta 357181 tcggcctgtt gatataaaac atactgacac tactgaagat ccgaatgcga tagagtttat 357241 ttcacaatgg agccgggagg aaacgaagaa acctttgccg ctatacgatt gtgatttgtt 357301 ccgtttttcc ttgttcacca taaaggaaaa tgaagtgtgg ttttacgcaa atgttcatca 357361 cgtgatttct gatggtatct ccatgaatat tctcgggaat gcgatcatgc acatttattt 357421 agaattagcc agcggctcag agacaaaaga aggaatctcg cattcattta tcgatcatgt 357481 tttatctgaa caggaatatg ctcaatcgaa gcggtttgaa aaggacaagg cgttttggaa 357541 caaacaattt gaatcggtgc ctgaacttgt ttccttgaaa cggaatgcat ccgcaggggg 357601 aagtttagat gctgagaggt tctctaaaga tgtgcctgaa gcgcttcatc agcagattct 357661 gtcgttttgt gaggcgaata aagtcagtgt tctttcggta tttcaatcgc tgctcgccgc 357721 ctatttgtac agggtcagcg gccagaatga tgttgtgacg ggaacattta tgggcaaccg 357781 gacaaatgcg aaagagaagc agatgcttgg catgtttgtt tctacggttc cgcttcggac 357841 aaacattgac ggcgggcagg cgttttcaga atttgtcaaa gaccggatga aggatctgat 357901 gaagacactt cgccaccaaa agtatccgta taatctccta atcaacgatt tgcgtgaaac 357961 aaagagctct ctgaccaagc tgttcacggt ttctcttgaa tatcaagtga tgcagtggca 358021 gaaagaagag gatcttgcct ttttgactga gccgattttc agcggcagcg gattaaatga 358081 tgtctcaatt catgtaaagg atcgatggga tactgggaaa ctcaccatag attttgatta 358141 ccgcactgat ttattttcac gtgaagaaat caacatgatt tgtgagcgca tgattaccat 358201 gctggagaac gcgttaacgc atccagaaca tacaattgat gaattaacac tgatttctga 358261 tgcggagaaa gagaagctgc ttgcgagggc cggcggtaaa tctgtgagct accgtaagga 358321 catgacgata ccagagctgt tccaagaaaa ggctgaactg ctttctgatc atccagcggt 358381 tgtatttgaa gatcgcacat tgtcctatcg aacgttacat gagcaatctg cacgcatcgc 358441 caatgtgctg aaacagaaag gggttggccc ggacagtcct gtcgcggttt tgattgaacg 358501 ctctgaacgg atgattacag ctatcatggg aattttaaaa gccggcggag cctatgtgcc 358561 gattgatccg ggttttcctg ctgagcgcat tcaatatatt ttggaggact gcggggcgga 358621 tttcatcctg actgaatcga aggttgcggc gcctgaagcc gatgctgagc tgattgactt 358681 agatcaggcg attgaggaag gtgcagaaga aagcctgaat gcagatgtga acgctcggaa 358741 ccttgcctac attatttaca catcgggaac aaccggacgc ccgaaaggcg ttatgatcga 358801 gcatcgccag gttcatcatt tggttgaatc tctgcagcag acgatttatc aaagcggcag 358861 ccaaaccctg cggatggcat tgcttgcgcc gttccacttt gatgcgtcag tgaagcagat 358921 cttcgcgtcg cttcttttgg gccaaaccct ttatatcgta ccgaagaaaa cagtgacgaa 358981 cggggccgcc cttactgcat attatcggaa gaacagcatt gaggcgacgg acggaacacc 359041 ggctcatttg caaatgctgg cagcagcagg cgattttgaa ggcctaaaac tgaagcacat 359101 gctgatcgga ggagaaggcc tgtcatctgt tgttgcggac aagctgctga agctgtttaa 359161 agaagccggc acagcgccgc gtttgactaa tgtgtacggg ccgactgaaa cgtgcgttga 359221 cgcgtctgtt catccggtta tccctgagaa tgcagttcaa tcagcgtatg tgccgatcgg 359281 gaaagcgctg gggaataacc gcttatatat tttggatcaa aaaggccggc tgcagcctga 359341 aggcgtggcg ggtgagcttt atatcgcggg agacggtgtg ggccgaggct atttacattt 359401 gcctgaatta acggaagaga agtttttaca agatccattc gtgccgggcg atcgcatgta 359461 ccggaccggg gacgtggtgc gctggcttcc agatggaaca atcgaatatt taggcagaga 359521 ggatgaccag gtcaaagtcc gcggataccg gattgagctt ggggaaattg aagccgtgat 359581 tcagcaggcg ccagacgttg caaaagccgt tgttttggca cgccctgacg aacagggaaa 359641 tcttgaggtt tgcgcatatg ttgtgcagaa gcctggaagc gaatttgcgc cagccggttt 359701 gagggagcat gcggccagac agcttcctga ctatatggtg ccggcttact ttacagaagt 359761 gacagaaatt ccgcttacac caagcggcaa agtcgaccgc cgcaagctgt ttgcactaga 359821 ggtgaaggct gtcagcggca ctgcctatac agcgccgcga aatgagactg aaaaagcaat 359881 cgcagccatt tggcaggacg tgctgaacgt tgagaaggcg gggatctttg acaatttctt 359941 tgaaactggc ggacattcat taaaagccat gaccctttta acaaagattc ataaggaaac 360001 aggcattgag attccgcttc aatttttgtt tgagcatccg acgattacgg ctcttgcaga 360061 ggaagctgat cacagagaaa gcaaagcttt tgcggtgatt gaacctgctg aaaaacagga 360121 gcattacccg ctttcattgg cacagcagcg aacatatatc gtcagccagt tcgaggatgc 360181 gggagtcggc tataacatgc cagcagcagc aattctggaa gggcctttag atattcaaaa 360241 gctggagcgc gcatttcagg gattaatccg acgccacgag tcattgagaa catcatttgt 360301 tcttgaaaac agcacgccga gacagaaaat tcacgatagc gttgatttca acatcgaaat 360361 gattgaaaga ggcggccgct cagatgaggc aattatggct tcattcgttc ggacatttga 360421 tttggcgaaa gctccgctgt tcagaatcgg tttgctgggg cttgaagaga accgtcatat 360481 gctgctgttt gacatgcacc atttgatttc tgacggtgta tccattggca ttatgctgga 360541 ggagttagca cgcatttata aaggcgaaca gcttcctgat cttcgtctcc agtataagga 360601 ctacgctgta tggcaaagca gacaggctgc tgaagggtac aagaaggacc aggcttattg 360661 gaaggaagtc tttgcaggcg agctcccggt gcttcagctt ctgtccgatt acccaagacc 360721 acctgttcaa agctttgaag gggatcgggt gtcaatcaag ctggatgcgg gggtaaagga 360781 tcgcctcaat cgtttggctg aacaaaacgg cgccacttta tatatggtga tgctttccgc 360841 ttactatacg cttttgtcaa agtatacggg gcaggatgac atcattgtcg ggacaccgtc 360901 agcgggcaga aatcactccg atacagaggg cattatcggg atgttcgtca atacgcttgc 360961 gattcgcagt gaggtgaagc agaatgagac gtttacccaa ttgatctcgc gtgtccgcaa 361021 acgggtgctg gatgcctttt ctcatcagga ctatccgttt gagtggcttg ttgaagattt 361081 gaacatcccg cgtgatgtta gcaggcatcc gctgtttgac acgatgttca gccttcaaaa 361141 cgcgacagag ggcattccgg ctgtcggcga tctttccttg tctgttcaag agaccaattt 361201 caagattgcc aaatttgatt tgacggtgca ggcgagagaa accgatgaag gcattgagat 361261 tgatgtggat tacagcacaa agctgtttaa acaaagcacg gcagacaggc tgcttacgca 361321 ttttgcgcgt ttgcttgaag atgctgcggc tgatccagag aagccgattt ctgagtataa 361381 gcttctttct gaagaggagg ctgcttcgca aattcagcag tttaacccgg gcagaacacc 361441 ttatccgaaa gataaaacaa ttgttcagct gtttgaggag caagcggcga atacgccaga 361501 ccacactgcg cttcaatatg aaggcgaatc actcacttat cgtgaactga atgaacgggc 361561 caatcgttta gcccgcggca ttctttctct tggagctggc gaaggcagaa ctgcggctgt 361621 cttatgcgag cggtcaatgg atatgattgt gtcgatcttg gcagtattaa aatcaggttc 361681 ggcttatgtt ccgatcgatc cggaacatcc gattcagcgg atgcagcatt tcttccgtga 361741 cagcggagca aaggtgcttc tcactcagag gaaattaaag gctttggcgg aagaagcgga 361801 atttaagggc gttatcgtgc tagccgatga ggaagaaagc tatcatgccg atgcgcgaaa 361861 tctcgcactg cctcttgatt ctgcagcaat ggccaacctg acgtatactt ccggaacgac 361921 tggaacacct aaggggaata tcgtgacaca tgccaatatt ctccgcacgg tgaaggaaac 361981 gaattatctc agcattacag aacaggatac gattctcggt ctttccaatt acgtgtttga 362041 cgcgtttatg ttcgatatgt tcggctcttt gttaaacgga gccaagctgg tgctgatacc 362101 gaaggaaacc gttttggaca tggctcgcct gtcccgcgtc attgaacggg agaacatcag 362161 cattctcatg attacaaccg ctttgttcca cttgcttgtg gacttgaatc cggcatgctt 362221 gtcaacgctt cgcaagatta tgtttggcgg ggaacgggct tcggttgagc atgtcagaaa 362281 agctttgcaa acggttggaa agggcaagct ccttcatatg tatggaccgt ctgaaagcac 362341 ggttttcgcg acgtatcatc cggttgatga attggaggag cacacgctgt ctgttccgat 362401 tggaaaaccg gtcagcaata cggaagtata cattcttgac cgtacgggac acgtgcagcc 362461 tgccgggatt gccggagagc tttgcgtcag cggcgaagga ctcgtgaaag gctattacaa 362521 ccgtccagaa ctgactgagg agaaatttgt tccccatccg tttacatccg gcgaacgcat 362581 gtataaaacg ggagaccttg cgagatggct gccgaatggc gacatcgaat ttatcgggcg 362641 aatcgaccat caggtgaaga ttcgcggaca gcgcatcgag cttggagaaa tcgaacatca 362701 gctgcaaacc catgatcgtg ttcaggaaag tgttgtgctt gccgttgatc aaggagcggg 362761 agataaactg ttgtgtgctt actatgtcgg agaaggagac atctcatcac aagagatgag 362821 agagcatgct gcgaaggact tgccggcata tatggttcct gcggtgttta tccaaatgga 362881 cgagctgccg ctgacaggga acggaaaaat tgaccggaga gcgctgccga ttcctgatgc 362941 caacgtttca agaggtgttt catatgttgc gccacgcaat ggaacggaac aaaaagtcgc 363001 ggacatttgg gcacaggtac ttcaggcaga acaagtcggc gcttatgacc acttctttga 363061 cattggcgga cattcattag caggcatgaa gatgcttgcc ttggttcatc aggaactggg 363121 cgttgagctg tcactcaagg atctcttcca gtcaccgacg gttgagggct tggcacaggt 363181 gattgcctct gctgaaaaag ggacagccgc aagtatcagc ccggcagaga aacaagatac 363241 gtatcctgtt tcttcaccgc aaaaacggat gtacgtgctt cagcagcttg aggatgcgca 363301 aacgagctat aacatgccgg cggttctgcg cctgacaggt gagcttgatg ttgaaaggct 363361 taacagcgtc atgcagcagt taatgcagcg tcatgaagcc ttgagaacca cgtttgaaat 363421 aaaagatgga gaaacggtgc agcggatctg ggaagaggct gagtgcgaga tagcctattt 363481 cgaagccccg gaagaagaga cagagcggat cgtttctgag tttattaagc ctttcaaaat 363541 cgaccaactt ccactgttca gaatagggct tatcaagcat tcagacactg agcatgtgct 363601 gctgttcgat atgcatcata ttatttctga tggtgcatct gtcggtgtgc tgattgagga 363661 gctttcaaag ctgtacgacg gagaaaccct tgagccgctc cgtattcaat ataaggatta 363721 tgccgtgtgg cagcagcagt tcattcagtc tgagctttac aagaagcaag aagagcattg 363781 gctgaaggag ctggacggag agctgccggt gctgacgctt ccgactgatt acagtcggcc 363841 tgccgttcaa acatttgagg gagaccgcat tgcattttca ttagaagcag gcaaagctga 363901 tgctctgcgc aggcttgcaa aagaaacgga ttccacgctt tacatggtgc ttctggcttc 363961 atacagtgcg tttttatcaa aaattagcgg gcaagacgat atcatcgtcg gttcacctgt 364021 ggccggacga tctcaagcgg acgtcagccg cgtcatcgga atgttcgtca atacattggc 364081 gctgcgcacg tatccgaagg gtgaaaagac gtttgctgac tatcttaacg aagtgaaaga 364141 aacggcactc agcgcttttg atgcgcagga ttacccactt gaggatttga tcggaaatgt 364201 tcaggttcag cgtgacacaa gcagaaatcc gttattcgat gcagtttttt caatgcaaaa 364261 tgcgaatata aaggatttaa caatgaaagg gattcagctt gagccgcatc cgtttgaacg 364321 gaaaacagcc aagtttgacc tcacgctgac ggctgacgaa accgacggag ggcttacatt 364381 cgtactcgaa tacaatacag ctctgtttaa gcaggaaacg attgaacgat ggaagcaata 364441 ttggatggag cttttagatg cagttactgg gaacccgaac cagccgcttt ccagcctgtc 364501 actggtcacc gagacagaaa agcaagcgct tcttgaggca tggaagggca aagcgctgcc 364561 tgtgccgaca gacaaaacgg ttcatcagct attcgaagag actgcccagc gccacaaaga 364621 ccgcccggct gtcacataca acggccagtc ttggacgtac ggcgagctga atgcgaaggc 364681 aaaccgtctc gcgcggattc tgatggactg cggcatcagc ccggatgacc gcgtcggcgt 364741 tctcacgaag ccgtcgcttg aaatgtccgc cgcggtgctc ggcgtcttga aagccggagc 364801 ggcgtttgtg ccgattgatc ctgactatcc ggatcagcgg attgagtata ttttacagga 364861 cagcggcgcg aagcttctct tgaaacagga aggcatttca gtgccggaca gctatacggg 364921 agatgtcatt cttctcgacg gaagccgcac gattctaagc ctgccgcttg atgaaaacga 364981 cgaggaaaat ccagaaaccg ctgtaaccgc ggagaacttg gcgtacatga tttacacgtc 365041 tggaacgacc ggacagccga agggtgtcat ggtcgagcac catgcgcttg tgaacctgtg 365101 cttctggcac cacgacgcgt tcagcatgac agcggaggac cgcagtgcga agtacgcggg 365161 ctttgggttc gacgcttcca tttgggagat gttcccgacc tggacgatcg gtgccgaact 365221 tcacgtcatt gaggaagcga tccgcctcga tatcgtccgc ctgaacgatt attttgaaac 365281 gaacggcgta acgatcacgt tcctgccgac acagcttgcg gaacagttca tggagcttga 365341 gaacacatca cttcgcgtat tgcttactgg aggagacaag ctgaagcgcg cagtgaaaaa 365401 gccgtacaca ctcgtcaata actacgggcc gacagagaat acggtcgttg ccacaagcgc 365461 agaaatccat ccggaggaag gctcgctttc catcggaagg gccattgcca atacgagagt 365521 atacattctc ggcgagggca atcaggtgca gccggaaggc gtagccggag agctttgcgt 365581 ggcggggcgc ggactggcac gcggctatct gaatcgagaa gacgaaaccg cgaagcggtt 365641 tgtcgctgat ccgtttgtgc cgggtgagcg catgtaccgc accggcgatt tggtgaaatg 365701 gacgggcggc ggcatcgaat acatcggccg gatcgaccag caggtcaagg tccgcggcta 365761 ccggatcgag ctctcagaaa ttgaagtcca gctcgcccag ctttctgagg tgcaggatgc 365821 ggcggtgaca gctgtcaaag ataaaggcgg caacacagcg atcgcggcgt atgtcacacc 365881 ggaatcagct gacatagaag cactgaaatc agcactgaag gaaaccctgc cggattacat 365941 gatcccggcg ttctgggtga cgctgaacga gcttccggtt acggcaaacg gcaaagtgga 366001 ccgcaaagcc ttgcctgagc cggacatcga agcgggaagc ggagaataca aagcgccgac 366061 gaccgacatg gaagagctgc ttgccggcat ctggcaggac gtgcttggaa tgtctgaagt 366121 cggtgtcacc gacaatttct tctcgcttgg cggagattcc atcaaaggaa ttcaaatggc 366181 gagccgcttg aaccagcacg gctggaagct ggaaatgaaa gatctcttcc agcacccgac 366241 gatcgaagag ctcacccagt acgtagagcg tgccgaaggc aaacaggcag accaaggccc 366301 ggtggagggc gaagtcatcc tgacgccgat ccagcgctgg ttctttgaaa agaacttcac 366361 gaacaagcac cactggaacc aatctgtgat gcttcacgcc aagaagggct ttgatcctga 366421 acgggtggag aaaacattgc aggcgctgat cgagcatcat gacgcgctcc gcatggtcta 366481 tcgtgaggga caggaagacg tcattcaata caacagaggt cttgaagctg cttcagctca 366541 attggaggtc atccagattg agggccaagc tgcagattac gaagaccgaa tagagagaga 366601 agcggagcgt ttgcaaagca gcatcgactt gcaggaaggc ggcttgttaa aagcaggctt 366661 gttccaagcg gaagacggag atcacttgct tcttgccatt caccacttag tggttgacgg 366721 cgtgtcgtgg cggattttac tggaggattt cgccgcggta tatacacagc ttgagcaagg 366781 caatgaaccg gttctcccgc agaaaacaca ttcatttgca gagtatgcag agagattgca 366841 agacttcgcg aactccaaag cctttttgaa agaaaaagag tattggagac agcttgaaga 366901 acaagctgtt gcggcaaagc ttccgaaaga ccgcgaatct ggtgatcagc gaatgaaaca 366961 tacaaagaca attgaattct cgctgactgc tgaagagaca gaacagctca ccacaaaggt 367021 gcatgaggca tatcacacag aaatgaatga tattttgctg acggcattcg gattggcaat 367081 gaaggagtgg acgggtcaag atcgagtaag tgttcattta gaggggcatg gacgtgaaga 367141 aatcatagaa gacctgacca tttctcgcac agtcggctgg tttacaagta tgtacccaat 367201 ggtgctcgat atgaagcatg cggatgatct gggctaccag ctgaagcaaa tgaaagaaga 367261 tatcagacat gtgccgaata agggagtcgg atacggcatt ctgcgctatc tgacggcacc 367321 ggaacataaa gaagatgtgg cgttctcgat tcagccggat gtcagcttca actatttagg 367381 tcagtttgac gaaatgtcgg atgcaggttt gtttacgaga tcagagctgc catcaggaca 367441 gtcattaagc cctgaaacag aaaaaccgaa tgcgctggat gttgtcggat atatcgaaaa 367501 cggaaaactg acgatgtcac tggcctatca ttctcttgaa tttcatgaaa aaacagtaca 367561 aacattcagt gacagcttta aagcgcatct tctcagaatc attgaacatt gcctatctca 367621 agatggtacg gaactgaccc cgagtgatct tggtgacgac gatttgacgc tggatgagct 367681 ggataaatta atggaaattt tctaatagag gtggcatatg agcaaaaaat cgattcaaaa 367741 ggtgtacgca ctgacaccaa tgcaggaggg aatgctgtat catgcgatgc ttgatccgca 367801 ttcttcctcg tacttcacac aattagagct tgggattcac ggcgcttttg atcttgaaat 367861 ctttgagaaa agcgtcaatg aactgattcg gtcatacgat attctccgta cggtatttgt 367921 gcatcagcag ctgcaaaaac cgcgtcaggt cgtgttagcg gaacgcaaaa caaaagtgca 367981 ttatgaggat atcagtcatg cagacgaaaa ccgccagaaa gagcacattg agcgttacaa 368041 acaagacgtt cagcgccaag gctttaacct ggcaaaagac atattgttca aggtagcggt 368101 tttccgcctt gctgcagatc agctgtatct tgtctggagc aatcatcata ttatgatgga 368161 cggctggagc atgggcgtcc tcatgaaaag cctgttccaa aactatgaag cgctcagagc 368221 aggcaggaca ccggcaaacg gtcagggcaa gccttattcc gattacatca agtggcttgg 368281 aaaacaggac aatgaagaag cggagagcta ctggagcgag cgcttggcgg gttttgaaca 368341 gccaagcgtg ctcccgggcc gcctgcctgt gaaaaaagac gaatacgtca ataaagaata 368401 ttcatttaca tgggacgaaa cactggttgc ccgtattcag caaaccgcaa atctccatca 368461 agtgacaggg cctaacctat ttcaggccgt ttggggcatt gttctcagca aatacaactt 368521 tacggatgat gtgatcttcg gaacggtcgt ctcgggacga ccgtctgaaa tcaacggaat 368581 cgaaacgatg gcggggctgt ttatcaacac cattccagtg cgggtgaaag ttgaacgaga 368641 tgctgcattc gctgatattt tcacagctgt tcagcagcat gcagtagagg cagagcgtta 368701 cgattacgtg ccgctctatg agattcaaaa acgctcagct cttgatggca atctcttaaa 368761 ccatctggtc gcgtttgaaa attatccgct tgatcaagag cttgaaaacg gcagcatgga 368821 agaccgcctc gggttttcga ttaaggtaga aagcgcattt gaacaaacga gcttcgattt 368881 caacctgatt gtgtatccgg gcaaaacgtg gaccgtcaaa attaaatata acggagccgc 368941 ctttgattcc gcttttatcg aacggacagc ggagcacctt acccgcatga tggaagcagc 369001 tgtcgatcag ccggccgctt ttgtgcgtga gtacgggctt gtgggagacg aagagcagcg 369061 gcaaattgtc gaggtgttta acagcacgaa agccgaactc cctgaaggaa tggctgttca 369121 ccaagtgttt gaagagcaag cgaaacggac gccggcgagc accgccgtcg tatatgaagg 369181 aaccaagctg acgtaccgcg agctgaatgc agcggctaac cgtctggcga gaaagcttgt 369241 cgaacatggg cttcaaaaag gggaaacagc agcgattatg aacgaccgct cagtagaaac 369301 cgttgtcggc atgctggctg ttttaaaagc aggcgccgca tatgtgccgc ttgatccagc 369361 gcttcctggg gatcgtcttc gtttcatggc agaggacagc tccgttcgaa tggttttgat 369421 cggaaattct tatacagggc aggcacatca gctgcaagtg ccggttctta cactggacat 369481 aggctttgaa gagagtgaag cggctgacaa tctcaacctg ccatccgccc cgtctgattt 369541 ggcgtacatc atgtacacat ccggttcaac gggcaaaccg aaaggcgtca tgatcgaaca 369601 taaaagcatt ctgcgcctcg tcaaaaatgc cgggtacgtt cctgttactg aagaagaccg 369661 catggcgcaa acgggagctg tcagctttga tgccggaacg tttgaggtat tcggcgcact 369721 gctgaatggc gcagcacttt atccggtcaa aaaagagaca ctgcttgatg cgaaacaatt 369781 tgctgcattc ctgcgtgagc aaagcatcac aactatgtgg ctgacatcac ctttattcaa 369841 ccagcttgct gcaaaggatg cgggtatgtt cggcacactg cgccatttaa tcatcggcgg 369901 agatgccctt gtcccgcata ttgtcagcaa agtaaaacag gcatcgccgt cgctttcatt 369961 gtggaacgga tacggcccga cagaaaacac gacgttttca accagttttc tgatcgaccg 370021 cgagtatggc ggctctatcc caatcgggaa gccgatcgga aattccactg cctatattat 370081 ggatgagcag caatgcctgc agccaatcgg cgcgcctggt gagctttgcg taggcggaat 370141 cggtgtagcg cgtgggtatg tcaatctccc tgagctgacg gagaagcaat ttctggaaga 370201 cccgttcaga ccgggtgaga gaatttaccg cactggtgac ttggcaagat ggctgccgga 370261 cggcaatatc gaatttttag gcagaatcga caaccaagtg aaggtgcgcg gcttccgaat 370321 tgagcttggc gaaattgaaa caaaactgaa catggctgag catgtgacag aagccgcggt 370381 gatcatacgc aagaacaaag cagacgaaaa tgaaatttgc gcgtacttca cggcggatcg 370441 tgaagtggct gtgagtgagc tgagaaaaac actgtctcag tctttgcctg actatatggt 370501 ccctgcccac ctgattcaaa tggacagcct gccgctcacg ccaaacggga aaatcaacaa 370561 aaaggaactg cctgcaccgc aatcagaagc cgtgcagccg gaatacgcag caccaaaaac 370621 agagagtgaa aagaaattag cggagatctg ggaaggaata ctcggcgtca aagcaggcgt 370681 taccgataac ttctttatga tcggcggcca ttctttgaaa gcgatgatga tgacggcgaa 370741 aattcaagag cattttcata aggaagttcc gataaaagtg ctttttgaaa agccgactat 370801 tcaagaactg gcactgtatt tggaagagaa cgaaagcaag gaggagcaga cgtttgaacc 370861 gatcaggcaa gcatcttatc agcagcatta tcctgtatcc ccggcccagc ggagaatgta 370921 tatcctcaat cagcttggac aagcaaacac aagctacaac gtccccgctg tacttctgct 370981 ggagggagaa gtagataaag accggcttga aaacgcgatt cagcaattaa tcaaccggca 371041 cgaaatcctc cgtacatcgt ttgacatgat cgacggagag gttgtgcaaa ccgttcataa 371101 aaacatatcg ttccagctgg aggctgccaa gggacgggaa gaagacgcgg aagagataat 371161 caaagcattt gttcagccgt ttgaattaaa ccgcgcgccg ctcgtccgtt cgaagcttgt 371221 ccagctggaa gaaaaacgcc acctgctgct cattgatatg catcatatta ttactgacgg 371281 aagttcaaca ggcattctaa tcggtgatct tgccaaaata tatcaaggcg cagatctgga 371341 actgccacaa attcactata aagattacgc agtttggcac aaagaacaaa ctaattatca 371401 aaaagatgag gaatactggc tcgatgtctt taaaggcgaa ctgccaatac tggatcttcc 371461 cgcggatttc gagcggccag ctgaacggag ctttgcggga gagcgcgtga tgtttgggct 371521 tgataagcaa atcacggctc aaatcaaatc gctcatggca gaaacagata cgacaatgta 371581 catgtttttg ctggcggcgt tcaatgtact cctttccaag tacgcgtcac aggatgatat 371641 cattgtcggc tcgccgacag ctggcagaac acatcctgat ctgcaaggtg tgccgggtat 371701 gtttgtcaac acggtggcac tcagaacggc accagcggga gataaaacct tcgcgcaatt 371761 ccttgaagag gtcaaaacag ccagccttca agcattcgag caccagagct atccgcttga 371821 ggagctgatt gaaaagcttc cgcttacaag ggatacaagc agaagtccgc tgttcagcgt 371881 gatgttcaac atgcagaata tggagattcc ttcattaaga ttaggagatt tgaagatttc 371941 ctcgtattcc atgcttcatc atgttgcgaa atttgatctt tccttggaag cggtcgagcg 372001 tgaagaggat atcggcctaa gctttgacta tgcgactgcc ttgtttaagg acgagacgat 372061 ccgccgctgg agccgccact ttgtcaatat catcaaagcg gccgcggcta atccgaacgt 372121 tcggctgtct gatgtagatc tgctttcatc tgcagaaacg gctgctttgc tagaagaaag 372181 acatatgact caaattaccg aagcaacctt tgcagcactt tttgaaaaac aggcccagca 372241 aacacctgac cattctgcgg tgaaggctgg cggaaatctg ttgacctatc gcgagcttga 372301 tgaacaggcg aaccagctgg cgcatcatct tcgtgcccaa ggggcaggaa atgaagacat 372361 cgtcgcgatt gttatggacc ggtcagctga agtcatggta tccattctcg gtgtcatgaa 372421 ggcgggggca gctttccttc cgattgatcc tgatacacct gaagaacgaa tccgttattc 372481 attagaggac agcggagcaa aatttgcggt cgtgaatgaa agaaacatga cggctattgg 372541 gcaatatgaa gggataattg tcagccttga tgacggtaaa tggagaaatg aaagcaagga 372601 gcgcccatca tccatttccg ggtctcgcaa tcttgcatac gtcatttata cgtccggtac 372661 gaccggaaag ccaaagggcg tgcagattga gcatcgtaat ctgacaaact atgtctcttg 372721 gtttagtgaa gaggcgggcc tgacggaaaa tgataagact gtattgcttt catcttacgc 372781 atttgacctt ggctatacga gcatgttccc tgtacttctg ggcgggggcg agctccatat 372841 cgtccagaag gaaacctata cggcgccgga tgaaatagcg cactatatca aggagcatgg 372901 gatcacttat atcaagctga caccgtctct gttccataca atagtgaaca ccgccagttt 372961 tgcaaaagat gcgaactttg aatccttgcg cttgatcgtc ttgggaggag aaaaaatcat 373021 cccgactgat gttatcgcct tccgtaagat gtatggacat accgaattta tcaatcacta 373081 cggcccgaca gaagcaacga tcggcgccat cgccgggcgg gttgatctgt atgagccgga 373141 tgcatttgcg aaacgcccga caatcggacg cccgattgcg aatgccggtg cgcttgtctt 373201 aaatgaagca ttgaagcttg tgccgcctgg agcgagcgga cagctctata tcacgggaca 373261 ggggctcgcg agagggtatc tcaacaggcc tcagctgaca gccgagagat ttgtagaaaa 373321 tccatattcg ccgggaagcc tcatgtacaa aaccggagat gtcgtacgaa gactttctga 373381 cggtacgctt gcatttatcg gccgggctga tgatcaggtg aaaatccgag gctaccgcat 373441 tgagccgaaa gaaattgaaa cggtcatgct cagcctcagc ggaattcaag aagcggttgt 373501 actagcggtt tccgagggcg gtcttcaaga gctttgcgcg tattatacgt cggatcaaga 373561 tattgaaaaa gcagagctcc ggtaccagct ttccctaaca ctgccgtctc atatgattcc 373621 tgctttcttt gtgcaggttg acgcgattcc gctgacggca aacggaaaaa ccgacagaaa 373681 cgctctgccg aagcctaacg cggcacaatc cggaggcaag gccttggccg caccggagac 373741 agcgcttgaa gaaagtttat gccgcatttg gcagaaaacg cttggcatag aagccatcgg 373801 cattgatgac aattttttcg atttaggcgg ccattcatta aaagggatga tgctgattgc 373861 caacattcag gcggaattgg agaaaagcgt accgcttaaa gcactgttcg agcagccgac 373921 agttcgccag ctggcggctt atatggaggc gtctgctgtt tcaggcggcc atcaagtact 373981 caaaccggct gacaagcagg atatgtatcc attgtcatcc gcacagaaac gaatgtacgt 374041 gctcaatcag cttgaccgcc agacgataag ctacaacatg ccatctgttc ttctaatgga 374101 aggagagctt gatatttcgc gcctgcgcga ctcactcaat cagcttgtga accgtcacga 374161 atcattgcgg acgtcattta tggaagctaa tggtgagcct gttcagcgca tcattgagaa 374221 ggcggaggtt gatcttcatg tgtttgaagc caaagaagac gaagcggacc aaaagattaa 374281 ggaatttatc cggccattcg acttaaacga cgcaccgctc attcgcgcag ctttgcttcg 374341 aatagaagcg aaaaaacatt tgctgctttt agatatgcat catatcatcg cagacggcgt 374401 ctcaagaggc atctttgtaa aagaattggc gctgctttac aaaggagagc agcttccgga 374461 gccgacgctt cattataaag atttcgccgt ttggcaaaat gaagctgagc aaaaagaacg 374521 gatgaaggag catgaggcgt actggatgtc agttctttca ggcgagctgc cagagcttga 374581 tctcccgctc gattatgccc gtccgcctgt gcaaagcttt aaaggagata cgatccgttt 374641 ccgtacggga agtgagacgg caaaggcggt agaaaaactg cttgccgaaa ccggaacgac 374701 cttgcacatg gtgctccatg ctgttttcca cgtcttttta agcaaaattt ccggacagcg 374761 ggatatcgtc atcggctccg ttactgccgg ccggacgaat gctgatgttc aggacatgcc 374821 gggaatgttc gtcaatacac ttgccctgag aatggaagcg aaagaacagc aaacatttgc 374881 ggagcttttg gagctagcaa agcagacgaa cctgtcagcc cttgagcatc aggagtatcc 374941 gtttgaagat ctggttaatc agcttgatct ccctcgggat atgagccgaa acccattgtt 375001 taatgtgatg gtgacgacag aaaaccctga taaagaacag cttacattgc aaaatctgag 375061 catttcacct tatgaggctc atcagggaac ttctaagttt gatctgacac tgggcggatt 375121 tactgatgaa aatggcattg gcttgcagct cgaatatgcg acagatctgt tcgcaaaaga 375181 aacagctgaa aaatggagcg aatacgttct gcggctacta aaggctgttg cggataaccc 375241 gaaccagccg ctttccagtc tgttactggt caccgagaca gaaaagcaag cgcttcttga 375301 ggcatggaag ggcaaagcgc tgcctgtgcc gacagacaaa acggttcatc agctattcga 375361 agagactgtc cagcgccaca aagaccgccc ggctgtcaca tacaacggcc aatcttggac 375421 gtacggcgag ctgaacgcga aggcaaaccg cctcgcccgg attctgatgg actgcggcat 375481 cagcccggat gaccgcgtcg gcgttctcac gaagccgtcg cttgaaatgt ccgccgcggt 375541 gctcggcgtc ttgaaagccg gagcggcgtt tgtgccgatt gatcctgact acccggatca 375601 gcggattgag tatattttac aggacagcgg cgcgaagctt ctcttgaaac aggaaggcat 375661 ttcagtgccg gacagctata cgggagatgt cattcttctc gacggaagcc gcacgattct 375721 aagcctgccg cttgatgaaa acgacgaggg aaatccagaa accgctgtaa ccgcggagaa 375781 cttggcgtac atgatttaca cgtctggaac gaccggacag ccgaagggtg tcatggtcga 375841 gcaccatgcg cttgtgaacc tgtgcttctg gcaccacgac gcgttcagca tgacagcgga 375901 ggaccgcagt gcgaagtacg cgggcttcgg gttcgacgct tccatttggg agatgttccc 375961 gacctggacg atcggcgctg aacttcacgt cattgatgaa gcgatccgcc tcgatatcgt 376021 ccgcctgaac gattattttg aaacgaacgg cgtaacgatc acgttcctgc cgacacagct 376081 tgcggaacag ttcatggagc ttgagaacac atcacttcgc gtcctcttga ccggaggaga 376141 caagctgaag cgggcagtga aaaagccgta cacactcgtc aacaactacg ggccgacaga 376201 aaatacggtc gttgccacaa gcgcagaaat ccatccggag gaaggctcgc tttccatcgg 376261 acgggccatt gccaatacga gagtatacat tctcggcgag ggcaatcagg tgcagccgga 376321 aggcgtagcc ggagagcttt gcgtggcggg gcgcggactg gcacgaggct atctgaatcg 376381 agaagacgaa accgcgaagc ggtttgtcgc tgatccgttt gtgccgggtg aacgcatgta 376441 ccgcaccggc gacttggtga agtgggtgaa cggcggcatc gaatacatcg gccggatcga 376501 ccagcaggtc aaggtccgcg gctaccggat cgagctctca gaaattgaag tccagctcgc 376561 ccagctttct gaggtgcagg atgcggcggt gacagctgtc aaagataaag gcggcaatac 376621 agcgatcgcg gcgtatgtca caccggaaac agctgacata gaagcactaa aatcaacact 376681 aaaggaaacc ctgccggatt acatgatccc ggcgttctgg gtgacgctga acgagcttcc 376741 ggttacggca aacggcaaag tcgaccgcaa agccttgcct gagccggaca tcgaagcggg 376801 aagcggagaa tacaaagcgc cgacgaccga catggaagag ctgcttgccg gcatctggca 376861 ggacgtgctt ggaatgtctg aagtcggtgt caccgacaat ttcttctcgc ttggcggaga 376921 ttccatcaaa ggaattcaaa tggcgagccg cttgaatcag cacggctgga agctggaaat 376981 gaaagatctc ttccagcatc cgacgatcga agagctcacc cagtacgtag agcgtgccga 377041 aggcaaacag gcagaccaag gcccggtgga gggcgaagtc atcctgacgc cgatccagcg 377101 ctggttcttt gaaaagaact tcacgaacaa gcaccactgg aaccaatcgg tgatgcttca 377161 cgccaaaaag ggctttgatc ctgaacgggt ggagaaaaca ttgcaggcgc tgatcgagca 377221 tcatgacgcg ctccgcatgg tctaccgcga ggaaaacggg gacatcgttc aggtgtataa 377281 accgatcggt gagagcaagg tcagcttcga aatcgtggat ctgtacggct ccgatgaaga 377341 gatgctgaga agccagatta agcttctcgc gaacaagctg caaagcagtc tcgatctgcg 377401 aaacgggccg cttttaaagg cggagcaata tcgcacagaa gctggggatc acctgctcat 377461 tgctgtacac catctcgtgg tcgacggtgt gtcatggcgg attttgcttg aagactttgc 377521 ttcaggctac atgcaggctg agaaagaaga gagccttgtc ttcccgcaaa aaacaaactc 377581 cttcaaggat tgggcggaag aactggcggc attcagccaa tcagcgcatc ttttacagca 377641 ggctgaatac tggtcgcaaa ttgccgctga acaggtttct cctttaccta aggattgtga 377701 aacagagcag cggatcgtca aggatacatc atctgtccta tgtgaattaa cggcagaaga 377761 cactaagcat cttttaacag atgttcatca gccatatgga actgaaatca acgatattct 377821 tctcagcgcg ctcggtttga caatgaaaga atggacaaag ggggccaaaa ttggcattaa 377881 ccttgaggga cacggccggg aggacattat cccgaatgtg aatatctcca gaacggtcgg 377941 ctggtttacg gcacaatacc ctgttgtgct cgacatatct gacgcagatg cctcagctgt 378001 gatcaaaaca gtcaaagaaa acctgcgccg cattccggac aaaggtgttg gctacggcat 378061 tcttcgttat ttcacagaaa cagcggaaac aaagggcttc acaccggaga tcagcttcaa 378121 ctatttgggc caattcgaca gtgaagtcaa aaccgatttc tttgaaccgt ccgctttcga 378181 tatggggcgc caagtaagcg gagaatcaga ggcgctgtac gcattaagct tcagcggcat 378241 gatcagaaac ggccggtttg tgctttcctg ctcctacaat gagaaggagt ttgaaagagc 378301 tacagtcgag gagcaaatgg aacggtttaa agaaaacctc ctgatgctaa tccgccattg 378361 cacggaaaaa gaagacaagg aattcacacc aagcgacttc agcgccgaag accttgaaat 378421 ggacgagatg ggagatatct ttgacatgct tgaggagaat ttaaaataaa acgcaaggga 378481 attacagaag gcgggagcga aacatatgag tcaatttagc aaggatcagg ttcaagatat 378541 gtattaccta tcgccgatgc aggaagggat gctttttcat gccatcctga atcccggcca 378601 aagcttttac cttgaacaaa tcacgatgaa agtaaaaggc agcttgaata tcaaatgtct 378661 tgaagaaagc atgaatgtga tcatggaccg gtacgatgta tttcgtaccg tgttcattca 378721 cgaaaaagta aaaaggcctg tccaagtcgt attgaaaaaa cggcagttcc atatagaaga 378781 aatcgatctg acacacttaa cgggcagcga gcaaacagcc aaaatcaatg agtacaaaga 378841 acaggataag atcaggggtt ttgatttgac gcgggatatt ccgatgcggg cagccatttt 378901 caagaaagct gaagaaagct ttgaatgggt gtggagctac caccacatta ttttggacgg 378961 atggtgcttc ggcatcgtcg tacaggatct atttaaggta tacaatgctc tgcgcgaaca 379021 aaagccgtac agcctgccgc ccgtcaaacc gtataaagac tacatcaagt ggcttgaaaa 379081 gcaggataaa caagcatcac tgcgttactg gcgcgaatat ttagagggct ttgaaggaca 379141 aacgacgttt gcggagcaaa gaaagaaaca aaaggacggc tatgagccga aagagctgct 379201 cttttcactg tcggaggcgg aaacaaaggc ctttaccgag cttgcaaaat cgcagcatac 379261 cactttgagt acggcgctgc aggcagtctg gagcgtattg atcagccgct atcagcagtc 379321 tggcgatttg gccttcggta cagttgtttc agggcgtccc gcggaaatca aaggcgttga 379381 acatatggtc gggctgttta tcaacgttgt cccgagacgt gtgaagctgt ctgagggtat 379441 cacatttaac ggcttgctca agcggctgca ggagcaatcg ctgcagtccg agccgcatca 379501 atatgtgccg ctttatgaca tccaaagcca ggccgatcag ccgaaactga ttgaccacat 379561 cattgttttt gagaactatc cgcttcagga tgcgaaaaat gaagaaagca gtgaaaacgg 379621 ctttgatatg gtggatgttc atgtttttga gaagtcgaat tatgatctca acctgatggc 379681 ttccccggga gatgagatgc tgattaagct tgcctataat gagaatgtgt ttgatgaggc 379741 gtttatcctg cgcttgaaat ctcagcttct tacagcaatt cagcagctca tccagaatcc 379801 tgatcagcct gtcagcacga tcaacctcgt tgacgacagg gagagagaat ttttgctaac 379861 cggcttaaac ccgccggctc aagctcatga aacaaagcct ctgacgtatt ggttcaagga 379921 agcagtgaac gccaatccgg atgcaccggc gcttacgtat tccggccaga ccctgtctta 379981 tcgcgaatta gatgaggaag cgaaccgcat tgcacgccgg ctgcaaaaac acggtgcggg 380041 caaaggctct gttgtagcgc tgtacacgaa gcgctcactt gaactggtga tcggcattct 380101 cggtgtatta aaggcgggag cagcctatct gccggttgat ccgaagctgc cagaggaccg 380161 aatctcgtat atgctggctg acagtgcggc agcctgtctt ctgacgcatc aggagatgaa 380221 agaacaagcg gctgagctgc cgtatacagg cacaacgctc ttcattgatg atcaaacacg 380281 gtttgaagaa caggcaagcg atcctgcaac cgcgattgat cctaatgatc cggcatatat 380341 catgtacacg tccggcacaa ccggaaagcc aaagggcaat atcaccactc atgccaatat 380401 tcaaggattg gtcaagcatg tagactacat ggcattttct gatcaggata cgttcttgtc 380461 tgtttcgaat tacgcctttg atgcatttac ctttgatttc tatgcttcta tgctgaatgc 380521 ggcacggctc attatcgcag atgaacatac gctgcttgat acagaacggc tcacagatct 380581 gatcctgcaa gagaatgtca atgtcatgtt tgcgacaacc gcactattta atcttctcac 380641 agatgcggga gaggattgga tgaaggggct tcgctgtata ttattcggcg gagagcgcgc 380701 gtcagtgcct catgtcagaa aagcgctgcg gatcatgggg ccgggcaagc tgattaactg 380761 ctacgggccg actgagggaa cagtgtttgc gacagctcac gtcgtgcatg atctgccgga 380821 ttccatctcc tcattgccga tcggaaagcc gatcagcaat gccagtgttt atattctgaa 380881 tgagcaaagc cagctccagc cattcggggc ggtcggtgaa ctgtgcatca gcggaatggg 380941 cgtgtcaaaa gggtatgtaa atcgtgctga cctcacgaag gaaaagttta tcgagaaccc 381001 gttcaagccg ggagaaacgc tttaccgtac aggggattta gcgcgctggc tgccggatgg 381061 aacgattgaa tacgccggcc gtattgacga ccaggtcaaa atacgcggac accggattga 381121 gcttgaagaa atcgaaaagc agctgcagga atacccaggt gtgaaagatg cggtcgttgt 381181 ggcggaccgc catgagtctg gcgatgcatc aatcaatgcc taccttgtga accgaacgca 381241 gctttcagct gaagacgtga aggcgcacct gaaaaaacag cttcctgctt acatggtgcc 381301 gcaaaccttt accttcttgg atgagcttcc tttaacgacg aacgggaaag tcaataaacg 381361 gctgctccca aaacctgatc aggatcagct ggcggaagaa tggattggac cgcggaacga 381421 gatggaagaa acaatcgcac aaatatggtc tgaggttctc ggcagaaagc aaattggcat 381481 tcatgacgat ttctttgcgc tcggagggca ttccttgaag gccatgaccg ccgcgtcccg 381541 catcaagaaa gagctcggga ttgatcttcc agtgaagctt ttgtttgaag cgccgacgat 381601 cgccggcatt tcagcgtatt tgaaaaacgg gggctctgat ggcttgcagg atgtaacgat 381661 aatgaatcag gatcaggagc agatcatttt cgcatttccg ccggttctgg gctatggcct 381721 tatgtaccaa aatctgtcca gccgcttgcc gtcatacaag ctatgcgcct ttgattttat 381781 tgaggaggaa gaccggcttg accgctatgc ggatttgatc cagaagctgc agccggaagg 381841 gcctttaaca ttgtttggat attcagcggg atgcagcctg gcgtttgaag ctgcgaaaaa 381901 gcttgaggaa caaggccgta ttgttcagcg gatcatcatg gtggattcct ataaaaaaca 381961 aggtgtcagt gatctggacg gacgcacggt tgaaagtgat gtcgaagcgt tgatgaatgt 382021 caatcgggac aatgaagcgc tcaacagcga agccgtcaaa cacggcctca agcaaaaaac 382081 acatgccttt tactcatact acgtcaacct gatcagcaca ggccaggtga aagcagatat 382141 tgatctgttg acttccggcg ctgattttga catgccggaa tggcttgcat catgggaaga 382201 agctacaaca ggtgtttacc gtgtgaaaag aggcttcgga acacacgcag aaatgctgca 382261 gggcgaaacg ctagatagga atgcggagat tttgctcgaa tttcttaata cacaaaccgt 382321 aacggtttca taaatgaagt gatgaaagga ggagacagcc aatgagccaa ctcttcaaat 382381 catttgatgc gtcggaaaaa acacagctca tctgttttcc gtttgccggc ggctattcgg 382441 cgtcgtttcg ccctctccat gcttttttgc agggggagtg cgagatgctc gctgccgagc 382501 cgccgggaca cggcacgaat caaacgtcag ccattgagga tctcgaagag ctgacggatt 382561 tgtacaagca agaactgaac cttcgccctg atcggccgtt tgtgctgttc ggacacagta 382621 tgggcggaat gatcaccttc aggctggcgc aaaagcttga gcgtgaaggc atctttccgc 382681 aggcggttat catttctgca atccagccgc ctcatattca gcggaagaaa gtgtcccacc 382741 tgcctgatga tcagtttctc gatcatatta tccaattagg cggaatgccc gcagagcttg 382801 ttgaaaataa ggaggtcatg tcctttttcc tgccttcttt ccgatcagat taccgggctc 382861 ttgaacaatt tgagctttac gatctggccc agatccagtc gcctgttcat gtctttaacg 382921 ggcttgatga taaaaaatgc atacgagatg cggaagggtg gaagaagtgg gcaaaagaca 382981 tcacattcca tcaatttgac ggcgggcaca tgttcctgct gtcacaaacg gaagaagtcg 383041 cagaacggat ttttgcgatc ttgaatcagc atccgatcat tcaaccgtga tcaaaagcgg 383101 acagcttcgg ctgttccgct ttttttgtgt tgaatgccaa tttctgcatg gtataatagt 383161 cgaaatactc aaataaaggc aggtcgaaac atgcgcacgt ctcccaggat gaaatggttt 383221 gtattgctgt ttacgtttgt tttcgccatc ggaatgaact cattcagaaa ttcctttcaa 383281 ttttttatgc tgccaatggc agacgccttc catgccgaca ggtcgctgat ttcggtttct 383341 gtcagcattt ttatgatcac aaccggcatc gtccagtttt ttgtcggttt ttttatcgac 383401 cgtttcagtg tcagaaaaat tatggcgctg ggagctgttt gcatcagcgc aagctttttg 383461 gtgcttcctt attcaccgaa tgttcatgtg ttttccgcca tttacggtgt gcttggcgga 383521 atcgggtatt cctgcgcggt cggcgtgacg acccagtatt tcatcagctg ttggtttgac 383581 acacacaaag gtctggcgct tgctattttg accaatgcca actctgcggg cctgctgctt 383641 ctctcgccca tttgggctgc ggctccgtat catgccggct ggcagagcac ctataccatt 383701 ttgggaatcg tcatggcggc tgttctgctg ccgctcctcg tctttgggat gaagcacccg 383761 ccacatgcgc aagcggaaac tgtgaaaaaa tcttatgatt ggcgagggtt ttggaacgtg 383821 atgaagcaat cccgcctcat tcatatcctg tacttcggcg tgtttacttg cggatttaca 383881 atgggaatta ttgatgctca cctcgtcccg atactgaagg atgcgcatgt ctctcatgtc 383941 aacggaatga tggccgcgtt cggggcattt atcatcattg gcggattatt ggcgggctgg 384001 ctgtcagatc tcctcggcag cagaagcgtc atgctatcca tcttattttt cattcggctg 384061 ctcagcctca tttgcctgct cattcccatt ctcggaattc atcacagcga cctttggtac 384121 ttcgggttta tcctgttatt cgggctcagt tacacaggcg tgatcccgct gaccgcggcg 384181 tcaatttcgg aaagctatca aacaggattg atcggatcgc tgttaggcat caatttcttt 384241 atccatcagg ttgccggagc tctcagcgtg tatgcgggcg gtttgttttt tgacatgact 384301 catggttatt tactgattgt cgctgtgtgc atcgtgtttg tgggtttatc ggctgtaata 384361 gagctggtgc cgtttttaga taaacagaag gcaaaagaaa cccaccattc aatataaaag 384421 gatcagcact gtcaatgctg atccttttta aatttgagtt tttttgtttc ggtattttta 384481 aggataatct ccttgaatct gttcatctcc tcttcggagt gaaaaaaatg tttggggatc 384541 gcaatatatt ggccacttga tgtattgacc ctgaagatat ttttatattc gaaaacagct 384601 gtaatttcat cccaattgaa aatgaggtca tattttttag aacatatacg aattccttct 384661 tggttcagag tatatgttct tttggatttc atccgttcgt tcttcttgta tgctctggaa 384721 aacttcacat atagaagaag gaggagcagc agtgtaaaca gaacggacat cacgataatc 384781 aacatactgt tcataaacaa gttaagcgcg tcacttccat aaacgatacg gggccatccg 384841 ttaatgaagt taactgcagc aaatatggcg caaaacaata gaaagtaaaa gcatgatatt 384901 tttgcgattt gataaaaaaa gatttctctt acatccttaa aagtgatttc tcctggaaga 384961 ttgatacttt cactagcata ttgaatcata cggtaaacct acacctctaa ccatgttttt 385021 ccttttagtc tagcataatt tctcattttt ttgcaggcat accagggcgc tttgtttttt 385081 tctccagatt gatattgctc cccaccacgc caatcataat acaaacagcc ccggcaagat 385141 gataccaggc caggctttcg ttgagaatca caaatcctgc aatcatcgtc acaatggtag 385201 atacatgatt aaaagcgctc attttaaacg cctcaattcg cgacagcgta tagttagaca 385261 gaaatgaagt gacaagtgaa gacagcacgc ccaaatacac aatggcgaga acgaagccgg 385321 gctcccggaa cggcagaaaa taagtgccga ctgttcccgc cgctccgtga cgcacaaggg 385381 cgatggcgtt gaagacgaca aagccgatgg ctgacatgat gtaggtgagc tcggtcagct 385441 tgaaccgctg cgtcattttt ctggcagcag tattgtacat cgctgaagac aaagcggaca 385501 ataggatcag caaagaccct tttaagctgg ctgattccac gtcaacgcct ttcatcacaa 385561 aaataaacat gacgccggca acggataaaa ccgtgaaccc cttttgcgtc cacgttgggc 385621 gttcctttaa aacataagcg gcaaagacca tcgtgaaaat cggaatggct gcctgaataa 385681 ttcccgcttc agaggaggac gagtacacaa ggccgaatgc ctgaaagctg aaaaataacg 385741 cgggatacag cagggcgagc ggcaaaatgt caatgacgtc ctttacgcgg attgatagct 385801 ttacccagcc gaataagatc ggtacagtgg ccgcagcaaa cgcaatggtg aaccgatgcg 385861 ccaaaatatc aaacggctct gctgtttgca gtgcgatttt tacgaataga aaggataaac 385921 cgataatgaa cgaatataaa atagccgcta tataagcggg ggtttgctga tgtttaacca 385981 taatgggaag ggctccttta cctgaattgc agcgccggtc gctcccttta ttgtatggcc 386041 gcggtcagaa cggtacaatg agaaaaacaa tgaactgtac cggtacaaaa cagggggaga 386101 aggcatggag aaatatatga gtctattaac gaggatagag gagatgatgc aaagcacctc 386161 atatcaagaa ggagacaggc ttccatctat ccgtcagctg tccgcccgct accaagtcag 386221 caaaagcaca gtgatccgcg cgctgcagga gctggaaaag cgccacctta tctattctgt 386281 tccgaaaagc ggctattata ttgtgaaaaa gtcagggaaa tcaaaaagcg ggcagcctgg 386341 ccccatcgac tttgccacat ctgcgccgga tcccgatgtg tttccgtatc ttgattttca 386401 gcactgcatc aacaaagcga ttgatacata caaaaacgat ttgtttattt atgggacgcc 386461 aaaggggctt ccatcactca tccgcgtact ccgaaagctc ttggccactc aacaggtatt 386521 tgcggatgaa cggcatattt tcattacatc aggtgtccag caggcgttat ccttgctttg 386581 tgccatgccg ttcccaaatg ggaaagagaa gatcgccatt gaacagccgg gctaccattt 386641 gatggtcgaa cagcttgaga cacttgggat tcccgccatc ggggtgaaac gaacggaaga 386701 agggcttgat atagccaagg ttgagcggtt atttcaaaca gaatcgatta aattttttta 386761 tacgatgccg cgcttccata acccgcttgg gtgctcattg tcagagcgtg ataaacagga 386821 gcttgtgaga ctggcagaag cgtatgatgt ctatctcgtt gaggatgatt acctcggtga 386881 tctggaggaa aataaaaagg cagatccgct gtacgcatat gatctgtcct cacatgtcat 386941 ctatttgaaa agcttctcga aaatgatgtt ccccggcctc cgcgtggggg cggctgtttt 387001 gcccgaagcg ctgactgaca cgttctatgc gtacaaaaag ctgaacgaca tcgactgttc 387061 gatgatttct caagcggcat tggagattta cctgaaaagc ggtatgtacg gcaggcataa 387121 ggagaaaatc agagattctt ataaagagcg gtcgctgagg ctacatcaag ccattcgaac 387181 tcacaggcag ctgggaagcg gacgctttac gttctccagc gggcaggcac cctgtatgca 387241 cacccatctg gtgcttcctc aggatctgcc cgcctcaaga gtgattcata gactggaaaa 387301 acaaggggtt ctccttgagg cgatagaccg tcattattta tcagattatc cgaaagaaaa 387361 tctattaaaa atcaatattt ccaatgtgaa aacggaagat attgagcgcg gtgtcaagct 387421 gttgatgagc catttataaa agctcttcgt acgagaccat tgtgatatcc tcggggaaat 387481 cagggtgtac ggcgcataca gccattttgt agccgggatc gacctcatac gttttgatat 387541 agcatgggga atggctgtcc ggaagctcaa tggatacttg tccgtcctgg tgcaggcgca 387601 ctgaaaagga atcaagcgga agcgataagc ctttgccttc cttgtttgat aaagctttct 387661 ttcattgacc atagatgata aaaatagtct gtctgctcgt ccttgtcttt tgctaaaagg 387721 tcgctgtact ctgtttttga aaagaagcgc ttggcgatct caaggctgat cggtttcgtt 387781 ttttcgatat ctatgccgat cggctgtgaa tcaaacgcgc aaatgaccca gcgtccggag 387841 tgagaaatgt tgaaatgagc gtcgggaaga tcagggatgc acggcttccc gtattcctgc 387901 gtgctaaagc ggatatcgga tttgtccaac tgatactgcc tgcttatgac tgagcgaacg 387961 agcacatctc ccagcagggt gcggtgagca tcttctttat gataaaatct ccggcatttc 388021 tcccgttttt caggtgatat gaaagacatg aaccgttcat tttcttcctg tgaaagcggg 388081 cggtccatat aaattccgta aatcttcatt ctagatcctc cgtctgcaaa agattgtcaa 388141 aaccatccta tcatacttcc acaagactca tatagaggag aaaataaaaa aacaaagcca 388201 aggcggcttt gttttagtgt acaggcggag atgctttcac tgcggctgtc cgccttgcca 388261 cagcataatt cagcaactgg attgactggg gcaatgaaaa acgcaaaata agtccggtga 388321 ggatggcggt caaaatggtg ccaaaaccga tcggtccgcc catgccccat gccgcaaaca 388381 aaatggttaa ttccatgccg ttccgcaccc attgcacatt ccagccggtt ttttctgtaa 388441 tcagcatcat cagtgaatca cgcggccccg cgccaaggcc tgctgataca taaacaccga 388501 cgccgtaacc aatcagcacc acgcctagag agaagacgat gatcgagcct gtgtaggtcg 388561 agagggcagg cagaatgaaa ttgaaaaaat ctataaatac accaatgagc accatattca 388621 ggagggcacc aattttcggc caagctctcg taaacaatga cgtgaatccg acgatgagcg 388681 ctccaataat gatggaccac tggccgacgg taagcccgaa gtgctgaaac aggctgtaat 388741 gaaatgcatc ccacggacta atgccgagtg cttttccttc tatcgtcagg gatacaccaa 388801 aagccaaaat gatcaaaccg gcaaaataaa atgtccagcg cagaacaagt tcttgcttca 388861 cgtgaggtcc cttctttcgt aaaaatcagt cgattgtcat tgtagcacat ctgacagaag 388921 ggcggaatag gcgaaagggg ctcaacaaaa aaacagggcc gccggaggcg ccctgtttca 388981 gcgtgttggc aaacccttgc attcgttgtc aggcctgtgc ttcggtgctc acgaatttaa 389041 cattagctgt gctccaatgc tcgcccttcc tagacttcaa aggttttcaa tcacgctgaa 389101 aatcacaaaa tcctaaaacg aatatcgttt taggattttg tcaataatct gaaacagggc 389161 gctgacgctc tgtttttctt attacagcgg gttcaaaatc cggtttaaga accgctgtgt 389221 ccgttcttct tttggtgcgg agaaaatttg ctccggcggt ccctgctcca cgataacgcc 389281 gccgtcgatg aagatgactt catccgcaac ctcctgcgcg aacttgattt cgtgggtcac 389341 gacgaccatg gtccagcctt cattggccaa gtccttgata accttcagca cctctccgac 389401 aagctcggga tcaagcgctg aggtcggttc gtcaaacagc atgagctcag gctgtatcgc 389461 cagtgcgcgg gcgatgccga cgcgctgctg ctggccgccg gaaagctgga acggatataa 389521 atccattttg tccttcaatc cgactttatc aagaagctga atcgcttctt ttctgacttc 389581 ctctttgttc cgtttttgca cctgaacagg gccctccatc acgttttcga gggctgtgcg 389641 gtgcgggaac aggtgatacg cctgaaacac cattccggat tttcggcgaa gctttaggat 389701 atccgcctgt ttcacctttt tggagaaatc gatggagaaa tcatcaaatg caagctctcc 389761 gcgattcggg atctccagag cgttcaggca gcggagcagc gtcgttttcc ctgaacctga 389821 aggcccaagt atggcgatga cttttccttt ttcaatcttc atatctatct tttttaaaat 389881 ttcattttca ccgaatgatt tgtttaatcc tttaacggta agcatactcg gaacctcctt 389941 atttggccac gtagcggtca agacgccgtt cgatgacatg ctggacgagt gagagcagga 390001 agcagataat ccaataaata aaggctgctt caatatagat cactaaaatt tgatcaagat 390061 tccgcgcgcc gatttcctgg gcttttctga acagctcagc gaccagaatt tgagaggcga 390121 gggatgtatc tttaatcagg ctgataaagg tattggataa tggcgggatc gacacacgaa 390181 acgcctgcgg caaaatgacg cggaacagcg ttttttgatg tgtcatgcca attgtgtagc 390241 cggcttccca ttgccctttc ggcacggata aaatagatgc ccgaatgatt tcagatgcat 390301 aggcgccgac gtttaatgaa aaggcgataa ctgcgcttgg aaatggatct aatgtgacgt 390361 taaaggccgg gaacagatag aaaatgatga acaattgaac gagaagagga gtgccgcgta 390421 ttgcggatac gtatacgctg aacacccatc tcaaaggtct cactttcgac attctggcaa 390481 gcgccgtaat cagcgccagg atcattccga atataaagga aagaatcgta aggggaatcg 390541 tatagtagat tccccctgaa agtatcggcc agaatgactg ctgcaccaga tcccacggga 390601 tcgccgtgcc aagcgtcaat gccggcagat tatttagaaa catcttcgcc gaaccatttt 390661 ttagaaattt tagaaagagt cccgtcctct ttcatttctt ttaatgcttt gttgacttga 390721 tcaacaacct cgccgcttcc tttacggaac gtgaaatatg ttgactgagg ctcacctgtt 390781 tcaaacgcga ttttcacgtt tttattgcca gatgttttta agtagttcaa tacggcaagc 390841 ttatcgttgt atgtcatatc gacgcggcct tgctggatca tttgaagggc ctgcgccatg 390901 ccttcaacgc cttctacttt agcgccggca tttgtagcta atttgttgta gttgcttgtc 390961 agtgattgag ctgacgtttt tccttttaca tctgcttcag acttaatatc gttgttgtct 391021 tttttcgtta cgacaacggc tcttgatgtt gtgtatttat ctgagaaatc atatttgtct 391081 tcacgatctg tttttccgac ttggttggca acaacgtcaa accgtttgga attcaggccg 391141 gcaaacatac tgtcccattg tgtttcctta aagtcgactt taagcccgag gcgttttgcg 391201 acttctgtga taacttcgac atcatagcca gtcagtttat cagtgtcttt gtcgtggtaa 391261 gtgaacggct catatgttcc ttccgttccg actgtgagca cacctttttt cttaattgaa 391321 gcccaaagat cgccatcttt ggcattatct tttgactgat tgtcatttcc tgctccgcaa 391381 gctgcaagag ctgcaatact tacgaccatg aataaagcca ataatgcttt tttcatctta 391441 ttccccactt ttctggttga ttttattgaa ataaaaaatt agcttacaaa tctaaaggat 391501 aacttttttt tagtatgagt caagtatttg gttttcataa gacaaaatct tttaaaataa 391561 atccaaaaat tgctgtgccg gtttaggcaa ataactgtcc gttctccaca tgacagccgg 391621 tgtcataatg aagggattat tttcgatatg gacggtgtga acgtgatttc tcatatgaac 391681 gggaatcatt gtgacaggca aaatagacgc gccgaatccg gatgacacga ggctgagcaa 391741 agttgcagag tcgtggcatt cacaaacaat gcgcggctcc aggttcaaac gatgaaattc 391801 attcatgacc tgattataga cgccttttcc gttgacaggc cgcagcagga tcagcggaaa 391861 tgaaggaatg tccaccatct taatggtgtc tccgcacgga tatccggctt catctgaaag 391921 cacgagcaca catggaatgt catcaagctg cttgaattgt actgtgtcac ttttgatcag 391981 tgttgtcgtg accgccgcat cgatttgccg gctttccagc agttccaaca gtgtcgcggg 392041 ttcattttcc caaatattaa aggtgagatg ggggtatctc tctttgatct gtgttacttt 392101 ttcaagcatc agagccgcgc aataaatcgt tgatcccacg gcaagtgtac cggctacttc 392161 ctccttcagc tcctgtacct caatgactgc atcttcaaac ctatgcagaa tctcttttgc 392221 tctttttaga aaaacagctc cttcatatgt aagagtcatt tgttttttct tgttacggtc 392281 aaacagaaca acaccaagtt cgtcctccag ctgtttgagc tgcctgctta aaggcggctg 392341 cgccatgtga agctttttgg ctgcggacgt aattttctgt tcttgggcaa tggtaatgaa 392401 gtatcgaagc tggcgaatat ccaaaagaaa gcgcctcctt atcatacctt ttaggtatta 392461 attatagatt taatagatat ttttcatatg gatatatcag gagtatgatt gaaatgaaag 392521 cagaattcaa gcgtaaagga gggggcaaag tgaaactcgt tgtcggaatg acaggggcaa 392581 caggggccat tttcggggtc aggctgctgc agtggctgaa ggccgccgga gtggaaaccc 392641 atctcgttgt gtctccttgg gcaaacgtca cgatcaaaca cgaaacaggc tatacgttac 392701 aagaagtaga acaactggcc acatacactt actcacataa ggatcaggcg gcagccattt 392761 caagcgggtc gtttgatacc gatggaatga ttgttgcgcc gtgcagcatg aaatctctcg 392821 caagcattcg cacaggaatg gcggataatc tgctgacacg tgcggcggat gtcatgctca 392881 aggagagaaa aaaactcgtc ctcttaacga gagagacgcc tttgaaccaa attcatctcg 392941 aaaatatgct agcgcttacg aaaatgggca ccatcattct tcctccgatg ccggcatttt 393001 ataatcggcc gagaagctta gaggaaatgg ttgaccatat tgtttttaga acgttggacc 393061 aattcggcat tcggcttcct gaagcgaagc gctggaatgg gattgaaaaa caaaaaggag 393121 gagcttgatc atggcttatc aagatttcag agaatttctc gctgcccttg aaaaagaagg 393181 acagctgctt acagtgaatg aagaggtaaa gccggaaccg gatttagggg cctccgcacg 393241 ggcagccagc aatcttggcg ataaaagccc tgcgctctta tttaacaaca tttacggcta 393301 tcataacgcg cgaattgcga tgaatgtcat cggctcttgg ccaaaccatg ccatgatgct 393361 gggcatgccg aaagacacac cggtaaaaga acagtttttt gaattcgcaa agcgttatga 393421 ccagtttccg atgccggtca aacgtgagga aacagcgcca tttcatgaaa atgaaatcac 393481 agaagatatc aatttgttcg atatactgcc tcttttcaga attaaccagg gtgatggagg 393541 ctactattta gacaaagcat gtgtcatttc ccgtgatctt gaggaccctg acaacttcgg 393601 caaacaaaat gtcggcattt acagaatgca agtcaaagga aaagaccgcc ttggcattca 393661 gcctgtcccg cagcacgata ttgcaatcca tctgcgccaa gctgaagaac gcggcatcaa 393721 ccttccggtc actattgcgc tcggctgtga gccggtcatt acaacggcgg catcgactcc 393781 gcttctctat gatcaatcag aatacgaaat ggcaggtgcg attcaaggcg aaccatatcg 393841 catcgtcaaa tcaaagctgt ctgatcttga tgttccgtgg ggcgctgaag tggtgcttga 393901 aggtgagatt attgccggag agcgcgaata tgaagggccg ttcggtgaat tcacaggcca 393961 ttattccggc ggacgcagca tgccgattat caaaattaaa cgcgtctatc acagaaacaa 394021 tccgatcttt gaacatttat acttaggcat gccttggaca gaatgcgatt acatgatcgg 394081 cattaacaca tgcgtgccgc tttatcagca gttaaaagaa gcgtatccga acgaaattgt 394141 ggcagtgaac gccatgtaca cacacggttt aatcgcgatt gtttccacaa aaacccgcta 394201 tggcggattt gcgaaagcgg tcggcatgcg cgcactcaca acgccgcacg gactcggcta 394261 ctgcaaaatg gtcatagtcg ttgatgagga tgtcgatcca ttcaaccttc cgcaggtcat 394321 gtgggcgctt tcgaccaaaa tgcatccgaa acatgatgcg gtcatcattc cggacttatc 394381 tgtcctgccg cttgatccgg gatccaatcc atcaggaatc actcacaaaa tgattctcga 394441 cgccactaca ccggttgcgc cggaaacaag aggccattat tcacagccgc ttgattctcc 394501 gctaacaacg aaagaatggg aacaaaaact aatggactta atgaataaat aaggaaagga 394561 tgttcgaaat gcatacatgt cctcgatgcg actcaaaaaa gggagaagtc atgagcaaat 394621 cgcctgtaga aggcgcatgg gaagtttatc agtgccaaac atgctttttt acatggagat 394681 cctgtgaacc ggaaagcatt acaaatcccg aaaaatacaa tccagcgttt aaaattgatc 394741 caaaggaaac agaaacagca attgaagttc cggcggtgcc ggaacgaaag gcttgatccg 394801 cgtgaactgt atgtcagacc gtctctttga gctgcttgac gggagctgcc tgaatgagaa 394861 gcagcatgag gccttcgttc tgcaaacagt atcagaggat ggctggccgc atgccgctat 394921 gatcagtgca ggtgaaatca tcgcgctgag ccgaactgat atccgaatcg ctctgtggaa 394981 aaacacaatg acttcggcca acatccttcg cacaggaaaa gcacagttca cggcgtggtg 395041 gaagggagcg gcctattatg taaagcttga atgcgcgcct ttaccgcctt tgaaagatgc 395101 cgaatatgaa agagaccgtt tttcctgccg catcgtttca gtgaaagagg acgttgcgaa 395161 atacgctgat ttgacttcag gtgtccgtat acagcttcac agccctgaag aggtgctgag 395221 cagatggaaa aagaccctgg aagatttaaa acggtaatat cgatagcctg acgccatgcg 395281 tcaggctttt tttatataat gaaaacaaaa gggggcgtga gaaatggaac gtgcggggat 395341 ctgtcactcg gacggctttg atttagctta tcgaattgag ggcgagggcg cacccatcct 395401 tgtgatcggg agtgcggttt actatccgcg ccttttttcc tcagatatca aacagaaata 395461 tcaatgggtc tttgtcgacc ataggggatt tgctaagcct aagcgggagc ttcgtgcgga 395521 ggattcgagg cttgatgctg tcttggctga tatcgaaagg atgagaacat ttcttcagct 395581 tgaggatgtt actatcctgg gacattccgg gcacgctttt atggctttag agtatgccag 395641 gacatatccc aaacaagttc ggaaggtggc gctctttaat actgcgcctg ataacagtga 395701 agaaagacag cgaaaaagcg aatcattttt catggaaaca gccagtcttg agagaaagaa 395761 acgctttgaa aaagacatcg agaatttgcc gcaggacatc gacaaagatc ctgaaaggcg 395821 ctttgtgcac atgtgtattc gcgctgaagc gaaaagcttt tatcaagagc ggccgcatgc 395881 tgctgcctta tgggacggtg tattcacgaa tatgccgatc attgatgaat tatggggcaa 395941 tacatttgcc cggattgatc ttcttcagcg gttagctgat gttcgtatgc cggtgtatat 396001 cggattaggg agatatgatt atttggttgc gcccgtttcg ctatgggatg ctgttgacgg 396061 tttatatccc catgttgata aggttatttt tgaaaagagc ggccatcagc cgatgctgga 396121 agaaccggaa gcctttgatc aaagcttcag gaaatggctt gatcaataaa aaacagcccg 396181 cagatcaaca tccgcgggct gtttctgatt ataagacccc tttcatcgcg cgtttgatca 396241 ccggcgagag cagcaggaga atgccgccaa gaacgataga aatcaaaccg atggtgccga 396301 agtacattgt ttcaggaatt ttatcaaaca atccggctac ttgggcattg atcgcttggg 396361 ctgctgcgtt cgtcagaaac cacatactca ttgtctgtgc agagaaggca gctggtgcca 396421 gtttcgttgt cacggataaa ccgactggag acaggcacag ctctccaagc acgacaagca 396481 ggaagctgag aacgagccaa agcgggctta cgagtgcttc ttttccttgc atagcaggga 396541 ataccataat gataaatgac aatccggcta aaataattcc gattgagaat ttaactggtg 396601 tagacggctg acgtttgcca agcttcatcc agagccatgc gaatattggc gcaaaaatga 396661 caacaaacaa tggatttaat gattggaacc atgatgactg aagttcgaat ccgcccaatg 396721 aaagtcttat gcgttcatca gcgtataccg caagaatggt cgctccctgt tcctgaatgg 396781 cccagaacat gacagcaccg ataaacaaag gaacgtaagc ggcaagacgg gatttttctg 396841 ttttgtccgc ttttttgctt gtaaacatga tgatgaaata aatcacagga atcaaaatac 396901 cgagaatact tacaaggtca atgaaacgtt tgatcgtcag cacgcctgtt tgtacagaga 396961 taatcactgc gatcgccaca atgataacac cgattccggt gccaattgca gattttttag 397021 acagcggatt cggcacattg gaacctgcaa gcccgaggtt tttctttctt gtcaaagcaa 397081 atacgataag tccgagaagc attccgaccg cggcagctcc gaatccgaga tgatagttgt 397141 acttctgtcc gagtgttccg acaattaacg gcgcgagtaa accaccgagg ttaatcccca 397201 tgtagaaaat actgaaacct gagtcgcggc gcgggtcttc tttcgtgtaa agatccccaa 397261 ctacgcttga aacgtttggt tttaataagc ctgttccgac aatgataagc accatactga 397321 tatagaatgc tatcgaactg cccggatagg cgagtgcaat gtggccgaac ataatgaata 397381 tgccgccgta aaacacggtg tttgcggtac cgaatacccg gtcagcgagc catccgccaa 397441 taatggtgga catgtatacg agtgatccgt aaatcgacat aatggcaacc gcagtgccct 397501 tgtcaaagcc gagccctccg tttaccgtct ctgtatacaa atagtaaagt aagattgctc 397561 tcattccata gtaagagaaa cgctcccaaa attcggtgaa aaatagtgta aatagtcctc 397621 gcgggtgacc aaagaaccct ttttgcggga cgcttttaat gatactttcg ttatcaatcg 397681 aagccatgtc agccaaaccc tttctaaaaa aagtgtatta taaaaatcat attcttatat 397741 aatacttgtg tcaatataat ttatactcat ttcaaatagt tccatattgg aaaaattata 397801 aatacctaaa aatagtgatt tcctcctaat ttttaaactt tttatcgtga gattttctta 397861 cacaactatt cctttatatt tttttaataa aattttagag aaatgtacaa gcagatcggg 397921 aggaccgctg gtgaatcaat cccctgtaac ggggattttt ttatgtccgt aaaccgcttt 397981 gaaaagccgc tgcacaccct cctgaatatc ttcttccttc agccgtgcaa agccgataat 398041 gagagcaggc ctgcccgttt gccgcttgtt ttccttcaag ttaaatcggc tcattccgaa 398101 tatttcaagc tgcagcccgg cagcatgtga caggatgtct tgttcggtgc gcctggtatc 398161 aaattcggta acaaaatgca gccccgcatt tgcccctttt acggtaacct ctccgctgaa 398221 ctctgcttct aaagcggtga tcaggcgttc tctcttttct ttataatgct gcttcatttt 398281 ttttatatgc ttctgatatt caccagactc gataaattcc tgcagggtga gctgtgtgag 398341 tgatgagcaa gtctgcagat catagccccg ctgtttgtat gccctcaaca gctcaggcgg 398401 caacaccata tagctgatcc gtaagccggg gagaagggac tttgaaaagg ttcccatata 398461 gatgacattt tgaaaacggt cgaggctttg cagcgccgga atactgtcta catcatatgt 398521 gaattcacta tcataatcgt cctcaatgat atatcggcgc ggctcctcgg ctgcccagtt 398581 cagcagctga attcttctgg atacaggcat aatcgttccg gacggaaact gatgcgacgg 398641 ggtggtcacc agcacatctg gctgctgtct ggtgatttca gcaatcgaca tgcctttttc 398701 atccagcatg atcgtcttta cttgttttcc ggcattcttc aaaagctgat acatgcgcct 398761 gtagccaggc tcctccatcg catacacggc ttccttgggt aaaagctcag tcaacagctg 398821 catgagcacc tgtgtgcctg cccctatgat catttgttcc ggcctgcatt ttacacccct 398881 cgtcagggaa atgagcctcg taatggccgc tctcacttca tatatccctt gcggatgtga 398941 catatcgccg agcgtgcggt atgagcggga ggccgctttt tgctcgcagc ggaaccagct 399001 tttgatcgga aaatggtctg tatcggaact catgtgtgaa aacgatatcc aatcgctctg 399061 gtcgatgtga atctctttta ggtcatccgg cagtgcaaat ggagggtgct cctcggcgga 399121 aaacatgtct agttcctcca cgaagaaacc ctttcgttca atggcgtaca aatacccctc 399181 agccagcagc tgctgatagg ctgaattcac tgaatttacg ctgaccttga gattttcagc 399241 cagctcccgc ttggagggaa ccttcgagtg cggcagcaga ttgcggctga ggatttcttt 399301 tttcagcttt tgataaattt gctgatagat ataatcggct tgttctgaac gatcgagtgt 399361 aatcgtgata tccattttgt agtttctcct tctgatacca tcaaaaagtt ataattggta 399421 cttttcatca taccaaagag aagtcagaat gataagaaaa taccgacagg gggatattca 399481 catgagtcaa acaacagcaa gcatcacaac tgcacaatgg cagcaaaaac gggatcaatt 399541 tgtgtcaaaa ggtgtgagca acggcaaccg cagtctggcg gtcaaaggag aaggggccga 399601 gctgtacgat ctggatggcc ggagatttat tgattttgca ggcgccatcg gcacgttaaa 399661 tgtcggacac tcgcatccga aggtggttga ggctgtgaag cggcaggcgg aggagctgat 399721 tcatcctggt tttaatgtca tgatgtaccc gacttatatc gaattagcag aaaaactgtg 399781 cggcatcgcg ccgggcagcc atgagaaaaa agcgattttt cttaactcag gggcagaagc 399841 ggtcgaaaac gctgtgaaaa tcgccagaaa gtatacaaag cgccaaggcg ttgtctcgtt 399901 tacacgcggg tttcacgggc gcacgaatat gacgatgagc atgacaagca aggtaaaacc 399961 ttataaattc ggtttcgggc cttttgcgcc agaggtttat caagcgccgt tcccttatta 400021 ttatcagaag ccggccggca tgagtgatga aagctatgac gatatggtca ttcaagcatt 400081 caatgatttc tttatcgctt cagtggcgcc tgaaacggtg gcgtgtgtcg tgatggagcc 400141 agtgcaggga gaaggcggat ttattattcc ttcgaaacgg ttcgtacagc acgtcgcttc 400201 attctgcaaa gaacacggca ttgtttttgt tgctgatgaa atccaaaccg gctttgccag 400261 aactggcact tatttcgcaa ttgagcactt tgatgtagtg cccgatctga tcacggtttc 400321 taaatcgctt gcggcaggcc tgccattaag cggtgtgatc gggcgtgcgg aaatgcttga 400381 tgcggcagcg ccaggggagc tgggcggcac gtatgccggc agcccgctcg gctgcgcggc 400441 ggctttggca gtcttggata ttatcgaaga agaaggactg aatgagcgat ctgaagaaat 400501 tggcaaaatc attgaagaca aggcgtatga gtggaaacaa gaattcccgt tcatcggtga 400561 catccgcaga ctcggggcga tggccgcaat cgaaatcgtc aaggatcctg acacgcgtga 400621 gcctgataag acaaaagcag cagcgatcgc ggcctatgcg aatcaaaacg gattactttt 400681 gctgacagcg ggaattaacg gtaatatcat ccgctttttg acaccgctcg tcatctcaga 400741 cagcctatta aatgaagggc tcagcatctt ggaggcgggc ctgcgagctt aatcattgga 400801 aagaaaatgg ccgggtctgc tatcatttta agtaatcatg aaaagaaagg aatgttcaat 400861 atgccagatc aattaacggt ctacaacccg gctacgggcg aggagatcaa aacgattcct 400921 cagcaatcag ccacagaggt agaagaagcc attgaacgtt cacatcaagc gtttaaaacg 400981 tggtctaaaa catcagcgaa cgaaagaacg tctcttttga aaaaatggta tgagctgatt 401041 gttgaacata aagaagagct tgcagattta attacaaagg aaaacggaaa accataccag 401101 gaagcagtcg gcgaggtact ttacggcgca ggctatatcg aatggttcgc agaggaagcg 401161 aagcgtgtgt acggaagaac ggtcccggcc ccgacaactg gtaaacgaat tgttgtcaca 401221 cgccagccgg tcggccccgt tgctgctatc acgccctgga atttcccgaa tgcgatgatt 401281 acacgcaaag cggcgcctgc tcttgccgcc ggctgtacat ttatcatcaa gccggcgccg 401341 gacacaccgc tgtctgctta tgaactagcg cgcctcgcat atgaagcggg cattccgaag 401401 gatgttcttc aggttgtgat cggcgatgga gaagaaatcg gaaatgtgtt cacaagcagt 401461 ccgaaaatcc gcaaaatcac gttcacaggc tcaacacctg tagggaaaat ccttatgaaa 401521 aacagcgctg acaccgtaaa gcacgtctca atggagctcg gcggacacgc cccgctgatc 401581 gtagatgaag atgcggacat tgaccttgcc gttgaacagg cgatggcgtc caaataccga 401641 aacgccggcc aaacctgcgt atgtgccaac cgcctgatcg ttcatgaatc cattaaagat 401701 gaatttgctg cgaaactgag cgagcaagtg tctaagctga aagtcggaaa tggacttgag 401761 gaaggcgtca atgtcggccc gattatcaac aaacgaggct tcgaaaaaat cgtcagccaa 401821 atagatgatg cggttgaaaa aggcgcgaaa gtgattgctg ggggcacata tgaccgaaac 401881 gatgacaaag ggtgctactt tgtgaatccg acagtgctca ccgatgtcga tacgtccatg 401941 aacatcatgc atgaggaaac attcggcccg gtcgccccga tcgtcacgtt ttctgatatt 402001 gatgaagcga ttcagcttgc caacgataca ccgtatggct tggctgctta cttcttcaca 402061 gaaaactacc gccgcggcat ctatatttcc gagaatctag agtatggcat tatcggctgg 402121 aatgacggcg gaccgtcagc ggttcaagcg ccattcggcg gaatgaaaga aagcggcatc 402181 ggccgtgaag gcggttcaga aggtatcgag ccgtaccttg aaacaaaata tttgtccatc 402241 ggtttataaa agaatgcacg ctcctgagag ctgccggatt ttccggcagc tctttttgtg 402301 ttccggcgaa taatcacaac aattccagcc aaaataacag caaatacatt ttgaaagaag 402361 gttccccaac aatggattta ttattggctc ttctcccggc tttgttttgg gggagcattg 402421 ttctcttcaa tgtgaaatta ggcggcgggc cgtacagcca gacactggga acgacgatcg 402481 gggcactcat tgtttctatc gttatttact tttttgttca gcccgttctg tcccttcgca 402541 tttttattgt tggaatcgta tccggcttat tttggtcact tggacaggcc aaccagttga 402601 aaagcattca attgatgggc gtgtcgaaaa caatgccgat ttccacagga atgcagctcg 402661 tttccacctc gctgttcggt gtgatcgtgt tccgcgaatg gtcaacaccg attgcgatta 402721 cgcttggcgt tctcgctttg atctttatca ttgtgggaat cattctcacg tccttggaag 402781 ataagaatga taaaaaagag ggcgagccaa gcaatttgaa aaagggcatt ttgattctcc 402841 ttgtttcgac tcttggttat ttggtttatg tagtcgtggc tagattattc aatgtgtccg 402901 gctggtccgc gctgctgcca caggcaattg gcatggtggt cggggggtta gttttaacct 402961 atagacacaa accctttaac aagtatgcga tcagaaatat tctcccaggg ttaatctggg 403021 caggcggaaa tatgtttttg tttatttctc agccgcgagt cggcgttgca acgagctttt 403081 ccctttcaca aatgggaatt gtcatttcta cgctcggcgg tattttcatc ctgcgtgaaa 403141 agaaaacgaa acgccagcta atagcaattg cgatcgggat tatcctgatt attgccgccg 403201 ccgtattctt aggaatcgcc aaaacaaatt cataacaaat ggaggaggat gtatatgtat 403261 ccggatttaa aaggaaaagt cgtcgctatt acaggagctg cttcagggct cggaaaggcg 403321 atggccattc gcttcggcaa ggagcaggca aaagtggtta tcaactatta tagtaataaa 403381 caagatccga acgaggtaaa agaagaggtc atcaaggcgg gcggtgaagc tgttgtcgtc 403441 caaggagatg tcacgaaaga ggaagatgta aaaaatatcg tgcaaacggc aattaaggag 403501 ttcggcacac tcgatattat gattaataat gccggtcttg aaaatcctgt gccatctcac 403561 gaaatgccgc tcaaggattg ggataaagtc atcggcacga acttaacggg tgccttttta 403621 ggaagccgtg aagcgattaa atatttcgta gaaaacgata tcaagggaaa tgtcattaac 403681 atgtccagtg tgcacgaagt gattccttgg ccgttatttg tccactatgc ggcaagtaaa 403741 ggcgggataa agctgatgac agaaacatta gcgttggaat acgcgccgaa gggcattcgc 403801 gtcaataata ttgggccagg tgcgatcaac acgccaatca atgctgaaaa attcgctgac 403861 cctaaacaga aagctgatgt agaaagcatg attccaatgg gatatatcgg cgaaccggag 403921 gagatcgccg cagtagcagc ctggcttgct tcgaaggaag ccagctacgt cacaggcatc 403981 acgttattcg cggacggcgg tatgacacaa tatccttcat tccaggcagg ccgcggttaa 404041 acataaaaag cgacccagac atgacatctg gatcgctttc tttattaggc acgctttttc 404101 tttacaagtg ctgctacaga taaaataatg gcagccgcag acagcaccat cgctgtaatg 404161 tctagagctg aagaacctga gttttcggaa tcgtcttctg ttttcgtggc gccgtgctca 404221 tctgtcactt gctttgcaga cgtgatgttt gtaatggaat gaggtgtatc ggcatcctcg 404281 tcacctgtcc actcaacaat gctgccgtct ttgtaatatt ggtatgcgtc ccaagcagct 404341 tcctccgctt tgtcagggtt tttggcaaca aaggtaaact gctggaactg gccttcctga 404401 atgcctccgt cagtcgcctc ccatgtcacg gatactgatt tgtcatcatg tttttgagtg 404461 gaaaccttcc agcccggaat tggctcatat tgctggaatt caacatcctt cggcattttg 404521 aggacaacct tcgttgtcgg cagatttttc tcagaaggaa ccttcattgt atacgtttcc 404581 caagagcctg cagcagactc agccggtttt acagaaacat gcgcgctggc aggggccgta 404641 aagaataaga gggagccgac aatagccgga catagtgtca atgcgatttt tttcaacaac 404701 gtaaacactc cttaattggt ctttgtaaac atgatattga tttcgttaaa gtcgccggtc 404761 aggccgtgga ctttgatctt ccagtttcct ttttcattaa tcgacaggtt ttgatcttgg 404821 aagacgcctt ttgttttttc ttttaatgta aaggtgcttt tgttttcgct gcctgacagg 404881 cctgttttat aaacggttaa cgtgatttgc tggatgtttt tcacgggatc accgttatgg 404941 tcggtgaccc gcagctcaaa aacatttttt ccaggctggt ttgggctgat gctgagagaa 405001 acgctttgtc cgttctctat cgctttggtt tggtagaacg gttccggcgc tggctcaggc 405061 gggcttggca ggcttgtaaa cacggccgct gtgatcaata cagcgatgcc gattgcccac 405121 tccgctttca acgttcggct gattcctgtg cggcgctgct ttctggtaag cagaaaatga 405181 attgcgccta agaccagcat gaaaacaaac agcccgcttt tcactaaaag agcttgtccg 405241 tacgctgtat ggaacagtga atccattgaa cgaatgatga aaaatccatt gagcaagcct 405301 gaaaacaaaa tgacgccgac tgcagtgagc gcccatgggg agaaccgtct gaccgtctcc 405361 cacgcgagcg ttttgtcagg ctgcctccat tcttttgaga gcagcaaaac gagtgccgct 405421 attccgccga cccagatgga agcggaagtt aaatgaagga aatccatcaa aatgccgacc 405481 gttttttctt caacgacagc agcatgcccg gtaaacgcct tggcaagcag gagaccgaaa 405541 aagaaaatga gcggcgctgt ccaatagcca aaggatgaaa agcggttttt ccgtatcgca 405601 gggatgacag acagtgcgag cagcacgaac agcgcagcct gtatgatcca aatggagccg 405661 cctgctgtct caaacagtgt ttctctgatg tagcccggct ggaatgcgct gccccagccg 405721 ccgcctgcgt tcgcttttgt ctgaatcgga agctgaagca aaagcgccag ccccaatgct 405781 gcgatcgagc cggtcaggat acgtctcgtc cgtttgacga gctgttctga tttcccttta 405841 taccagaaaa gatggaagaa aaccgttccg ataaacagag ataaggctgt atacagaatc 405901 gcgcgatctg ctgctgttcc cggattcagc gctgaatcgg ctgctttttg gctgctgaat 405961 ccgccatccg ctttcccgat actgaacgga atgacgccgg aaacaggatg tccatccgcg 406021 gatacggcat tccattccgc tctgtacaca tctttaggca gattcttctt cagcttcact 406081 gtcatgatgt gatgattatc ttttttgatt tcagtcttgt ccgtatccac acggtcgccg 406141 tttgaattat agactttaat gtaatgaaac ccttcttcaa ccggttcatt aaattcgatt 406201 tccacctgcg caggggcgct ttttaattcg ctgttttccc caggtgaaga tttgacaata 406261 taggcgtgag caaagcttgt tttcggcagg aaaacaagaa aaagcagaag gatgatccac 406321 catctgtttc gcttcatcac tcagacacca ccttccgctg tatgtgttgt gttatttctt 406381 ggtgcaggtg cagcgtttct ttcggtcttg aagcatgtct tccagcgctt ggtcgaaagt 406441 gcagacggct ccgccgaatc ctttttgaaa tcgttcggca tggtcaagtg tcgcaaacgg 406501 aatggcctgc ggctggcagc agtgcaggtt taattcagca tttacgacga aataagccga 406561 accggcactg acggttgtct gtaacagaaa atctctgcaa atcaagtgtg aaacctcttc 406621 cgttttatcc gcgtaacgca aaaacgcgca atgtgcgcag catagctgtt caatgtcttg 406681 gtttaccgta atcagctgaa ccgaatgagc ttgattgacg ggcttcaagc aatagctgca 406741 catatgatct gtttgaggtg ttcggacggg gagcgtgatg ccgccggccg ttttaatgac 406801 ctgatttgac tgaaccagct gattgacatc tctatatacc gtcatttccg aaacgccgaa 406861 ccttgcgctg atgtcagaaa ttctaagcga gccttcttct ttcagccact tcagtatgtg 406921 ttgctgtcta ttaatcggaa gcattcatac accctcttca ttaagatcta tttaagcgta 406981 gaggatttta gagacggaga caagtaagtg gatgataaaa aatgtgaaaa tgtgttgaac 407041 agcaacaaaa cgaaacagaa gggactctgg tataatagac agatggaata gaaagtgagg 407101 aataccctat gaaagaaaca ccatgcccga actgcggcaa acctttgaca ggcgatatgg 407161 tcagatcatc aaatgtgcct tgtcaatttc gctgcggcca ctgccgggaa cggctttatg 407221 aatataaagt ttcagctccg attatgctgg tatcattagc ggccatcgtg ctgcttattt 407281 atcttttgat gctcctccgc aatgcggcag gctcagtgct gccagctgta cagcacgtgc 407341 cgatggctgt atttgcgctt gtgtgcgcgt atcccgtttt tattgtgagt gagcggatga 407401 ttgcaaagta cgtgattcaa aatggcaaca tcatttatag aggaaagaga aaaggctcct 407461 gaaaccagga gcctttttat ttttaaaaaa ttgtcacagt catgtgccaa agtcctcttt 407521 actttcaatt gtatagggac tgtaagcgtt ttaacataga gtcaaaggga agcatcattc 407581 tctgaacata tttttgtatc ttacagcgac aaacaaaaca gggagggttt atatatgcag 407641 cagcaagaac agcagcaagg cggcatgaaa gtgaaagtgc aacgctttgg gagttatttg 407701 agcggaatga tcatgccgaa tatcggcgcg tttatcgcgt ggggtatcat taccgcgctg 407761 tttattccgg caggatggtt tccgaatgaa cagctgaaca cgctggtcag cccgatgatt 407821 acgtatttat tgccgctttt gatagcgtat acaggcggaa aaatgatcta cgaccaccgc 407881 ggcggagttg tcggagcgac agcggcaatt ggggtgattg taggatcgga tattccaatg 407941 tttttaggcg caatgattat gggtccgctt ggcggatacc tcattaaaca gactgataaa 408001 ttattcaagg ataaagtcaa gcaaggcttt gaaatgctga tcaacaactt tacggcaggg 408061 attgtcggcg cggctttaac gattctcgcg ttttacgcca tcggcccggt tgtcttgacg 408121 ctaaataaat tgctggcggc tggtgtggaa gtcattgtac acgctaattt actgccggta 408181 gccagtgttt ttgtagaacc ggcgaaagtg ttgttcctta acaacgccat aaaccatgga 408241 atcttaagcc cgatcggaat cgagcaagca tctcaaacag gaaaatcaat tctgttttta 408301 gtagaagcaa accctggacc ggggctcggc attttgctgg cctacatgtt ctttggcaaa 408361 ggatcttcaa aatcaacggc tcccggtgcg gcgatcatcc atttcttcgg agggattcac 408421 gagatttact tcccgtacat tctgatgaaa ccggccctga ttctcgcagc cattgccggc 408481 ggagcaagcg gactcttaac atttacgatc tttaatgccg gacttgtcgc ggcagcgtca 408541 ccgggaagca ttatcgcatt gatggcaatg acgccaagag gaggctattt cggcgtattg 408601 gcgggtgtat tggtcgctgc agctgtatcg ttcatcgttt cagcagtgat cctgaaatcc 408661 tctaaagcta gtgaagaaga cctggctgcc gcaacagaaa aaatgcagtc catgaagggg 408721 aagaaaagcc aagcagcagc tgctttagag gcggaacaag ccaaagcaga agaagcgtct 408781 gagctgtctc ctgaaagcgt gaacaaaatt atctttgcgt gtgatgcggg aatgggatca 408841 agtgccatgg gggcatccat cttaagaaac aaagtgaaaa aagcggagct tgacatcagt 408901 gtgaccaaca cggccattaa caatctgcca agcgatgcgg atattgtcat cacccacaaa 408961 gatttaacag accgcgcgaa agcaaagctg ccgaacgcga cgcacatatc agtggataac 409021 ttcttaaaca gcccgaaata cgacgagctg attgaaaagc tgaaaaagta atcttataga 409081 aagagagtga ttgtcatgca agtactcgca aaggaaaaca ttaaactcaa tcaaacggta 409141 tcatcaaaag aagaggctat caaattggca ggccagacgc tgattgacaa cggctacgtg 409201 acagaggatt acattagcaa aatgtttgaa cgtgaagaaa cgtcttctac gtttatgggg 409261 aatttcattg ccattccaca cggcacagaa gaagcgaaaa gcgaggtgct tcactcagga 409321 atttcaatca tacagattcc agagggcgtt gagtacggag aaggcaacac ggcaaaagtg 409381 gtattcggca ttgcgggtaa aaataatgag catttagaca ttttgtctaa catcgccatt 409441 atctgttcag aagaagaaaa cattgaacgc ctgatctccg ctaaaagcga agaagatttg 409501 atcgccattt tcaacgaggt gaactgacat gatcgcctta catttcggtg cgggaaatat 409561 cgggagagga tttatcggcg cgctgcttca ccactccggc tatgatgtgg tgtttgcgga 409621 tgtgaacgaa acgatggtca gcctcctcaa tgaaaaaaaa gaatacacag tggaactggc 409681 ggaagaggga cgttcatcgg agatcattgg cccggtgagc gctattaaca gcggcagtca 409741 gaccgaggag ctgtaccggc tgatgaatga ggcggcgctc atcacaacag ctgtcggccc 409801 gaatgtgctg aagctgattg ccccgtctat cgcagaaggt ttaagacgaa gaaatactgc 409861 aaacacactg aatatcattg cctgcgaaaa tatgattggc ggaagcagct tcttaaagaa 409921 agaaatatac agccatttaa cggaagcaga gcagaaatcc gtcagtgaaa cggtaggttt 409981 tccgaattct gccgttgacc ggatcgtccc gattcagcat catgaagacc cgctgaaagt 410041 atcggttgaa ccatttttcg aatgggtcat tgatgaatca ggctttaaag ggaaaacacc 410101 agtcataaac ggcgcactgt ttgttgatga tttaacgccg tacatcgaac ggaagctgtt 410161 tacggtcaat accggacacg cggtcacagc gtatgtcggc tatcagcgcg gactcaaaac 410221 ggtcaaagaa gcaattgatc atccggaaat ccgccgtgtt gttcattcgg cgctgcttga 410281 aactggtgac tatctcgtca aatcgtatgg ctttaagcaa actgaacacg aacaatatat 410341 caaaaaaatc atcggtcgct ttgaaaatcc tttcatttcg gacgatgtga cccgcgtagc 410401 gaggtcacct ctcagaaaac tgggagaaaa tgatagactt gtaggcccgg caaagaaaat 410461 aaaagaaccg aatgcactgg ctgaaggaat tgccgcagca ctgcgcttcg atttcaccgg 410521 tgaccctgaa gcggttgaac tgcaagcgct gatcgaagaa aaaggataca gcggcgtact 410581 tcaagaggtg tgcggcattc agtcccatga accgttgcac gccatcattt taaagaaact 410641 taatcaataa ccgaccaccc gtgacacaat gtcacgggct ttttttacta tctcgcaatc 410701 tagtataata gaaagcgctt acgataacag gggaaggaga atgacgatga aacaatttga 410761 gattgcggca ataccgggag acggagtagg aaaagaggtt gtagcggctg ctgagaaagt 410821 gcttcataca gcggctgagg tacacggagg tttgtcattc tcattcacag cttttccatg 410881 gagctgtgat tattacttgg agcacggcaa aatgatgccc gaagatggaa tacatacgct 410941 tactcaattt gaagcagttt ttttgggagc tgtcggaaat ccgaagctgg ttcccgatca 411001 tatatcgtta tgggggctgc tgctgaaaat ccggagggag cttgagcttt ccattaatat 411061 gagacccgcc aaacaaatgg caggcattac gtcgccgctt ctgcatccaa atgattttga 411121 cttcgtggtg attcgcgaga acagtgaagg tgaatacagt gaagttggcg ggcgcattca 411181 cagaggcgat gatgaaatcg ccatccagaa tgccgtgttt acgagaaaag cgacagaacg 411241 tgtcatgcgc tttgccttcg aattggcgaa aaaacggcgc agccatgtga caagcgccac 411301 aaagtctaac ggcatttatc acgcgatgcc gttttgggat gaagtctttc agcagacagc 411361 cgctgattat agcggaatcg aaacatcatc tcagcatatt gatgcgctgg ccgctttttt 411421 tgtgacgcgt ccggaaacgt ttgatgtcat tgtggcgagc aacttgttcg gtgatatttt 411481 aaccgacatc agctcaagcc tgatgggaag catcggcatt gcgccttctg cgaacatcaa 411541 tccatccggc aaatatccgt ccatgtttga accggttcac ggctcagctc ctgacattgc 411601 cggacagggc cttgccaatc cgatcggcca gatttggaca gcgaagctga tgctcgacca 411661 cttcggagag gaagaattgg gggcgaaaat tctggatgta atggagcaag tgactgccga 411721 cggcatcaaa acacgcgaca ttgggggaca aagcacaacg gctgaggtca ctgatgaaat 411781 ctgttcgcgc ttaagaaagc tctgatgaat caggccggtg gcagatggct gccccggcct 411841 gtccatttcc ttacgaaaat ttccacgaaa gtctaaccaa gcagatccaa atgctgtata 411901 ataatttgga attcttagga aagcatcggg tgaaggaagt tgaatgcaaa aacaatcacg 411961 ttaaagaaaa aaagaaaaat caaaacgatc gttgtactca gtatcattat gatcgcagct 412021 ctcattttta cgatcagatt ggtgttttac aagccttttc ttattgaagg atcatcaatg 412081 gccccaacgc ttaaagactc agaaagaatt ctggttgata aagcagtcaa atggactggc 412141 gggtttcaca gaggagacat catagtcatt catgacaaaa agagcggccg ctcatttgtc 412201 aaacgtttaa tcggtttgcc tggtgacagc attaaaatga aaaatgatca gctatacata 412261 aatgataaaa aggtggaaga accatactta aaggaatata aacaggaggt caaagagtcg 412321 ggtgtaacct taacaggtga cttcgaagtt gaggttcctt ccggtaaata ttttgtgatg 412381 ggagataacc gtctcaattc actggatagc agaaacggaa tgggcatgcc ttctgaggac 412441 gatatcatcg gtactgaatc tctcgtcttt tatccattcg gtgagatgag acaggcaaaa 412501 taaaatgcaa tgcaaaaaga acatggaaca tgacggcacc gataataaag cgccgtgcac 412561 gtttaaaaaa atgatgatga aacggtgcgg agccggcttt ccgccccgtt ttttatgata 412621 gaaagcgttt tgaagaaaag ggccctgttg aaataaacag aatcaggatt ggcgaagccg 412681 tgaagcgcat cgaattggta aatctcaaga tgggtatgct gtttttcccg cagttttttg 412741 ataagaagcg ctacgtcaaa cgacggctca taattaggga aaaacaatag gaccgggcag 412801 gctggcatgt gatgaagaga gtcgcgtatc cgggaaccgt aataacaaac cgatccgctc 412861 acctcaggca tactgctgca tttccatgcg atagtagccc ccacgctgaa tccaatcaca 412921 aagatgtgcc gtccggcgtt ttgcctgatc acattctgga tgatggtttc tcccgttttc 412981 agcctttcgt gttttgtaaa ttgttcgtat gccgtttttt cttctttcag tgtgtagact 413041 tcatcctcgc cgagcaggtt gggcgtcaac acatcatatc cagccatttt gatcagccgg 413101 cccatctttt tcatatggct gtttacacca tatatttcgt gtgcgagaat gacaagcggt 413161 tttgggaaca taacggcctc cttttgtgtt ttttccatta tatcctatcg tttcacttta 413221 ggctgagata taatggtcaa aaaaaggaga tataaaatga actcattatc tttgcctcac 413281 cgctatccat ttttgtttat tgatggcgtg acggatagcg agcccggcaa acatgcggca 413341 gcttataagc tgattagtga gaacgactgg tttatcactg atacgcaaac agaaatgccg 413401 ttttcacttg tgattgaagc gcttgcgcaa accgcggctt ttacaggaat tacagatgag 413461 aacagcttgg gattattgtc ttcggtgaag aaagcggaaa agctgggaga agctgtgcct 413521 ggtgaccggc ttgatcttac gtttgaagtc acgcgcaatc ggcgcgggtt tgtgttcgga 413581 catgccaagg catcagttgg agagcagcct gttgctgaag ctgaaatcgg catctatatt 413641 gaaaaatgaa aaaaaccctt cacaacattt tgtgaggggt tctattttgt gtcgtaatcc 413701 cgttcgcttt gagagttatc tctttgctgg cgtttgtgtt tttcatcatt catattttcc 413761 ttcagctctt cattaggaat cggatcggtt aagtcgttgt gctcggggtt ttcatttggt 413821 ttgttttgct gttttttttc tgtcatgttt gatcacctca ccgtttgttt tcctcttatt 413881 cattctcctc aaacatagga aatcgctttt ttgtcccgct gggtataatg tattagaata 413941 gagagaagca caacaaaaag ataaagagag gtacatatat gtctgttcaa agagaagatg 414001 tagatatcaa gctgatcgca attgatatgg atggtacact gctgaacgac gagcagctga 414061 tctcggatga aaaccgcaaa gccattcgtg aagcggagga taaaggtgtg tatgtggtga 414121 tcagcacggg ccggacgctg atgacgtgca gggagctggc ggaatcgcta aagctgtcat 414181 cctttctaat cacggcaaac ggcagtgaaa tttgggattc gaattttaat ttggtggaac 414241 ggaagctgct tcatacggac catattcaaa tgatgtggga tttgcggaat aagcacaaca 414301 ctaatttctg ggcttctacg gtgaataaag tatggagagg cgagtttccg gaaaacatta 414361 cggatcatga atggctcaaa ttcggctttg acatcgagga tgacgatatc cgaaacgaag 414421 tgcttgagga gctgagaaaa aacaaagagc tcgaaatcac aaattcaagt ccgacaaaca 414481 ttgaagtcaa cgcgcttggc atcaacaaag ctgcagccct tgccaaggtt acggaaaaac 414541 tcggctttac aatggagaat gtgatggcga tgggcgacag ccttaatgac attgcgatga 414601 tcaaagaagc gggtcttggc gtcgcaatgg gcaatgcgca agacatcgta aaagaaacgg 414661 ctgattatat cacggataca aatattgagg atggtgtcgc taaagcgatt cgccattggg 414721 tactataaaa aaagagagtc ctaagatgga ctctcttttt tagtttggca ggttttattc 414781 tgggaccatg gtaggttttc tgacaaaagt atttcacaaa ctgatatgat tcacttataa 414841 tgaaataaag ttcaaaaatt cggaatagtc gttccgaatt tcgggacaat aaatgacata 414901 aagcatatcg tttgctttgg caggagggat tctgtgtttc agattgattt aaactgtgat 414961 ttaggagaaa gcttcggagc ctacaagata ggccttgacc aagatatttt agagtatgtg 415021 acatcagcga atatcgcatg cggatttcat gcaggagatc ctagtgttat gcgaaaaacc 415081 gtcgcgcttg cagcagaaag aggcgtgaaa atgggtgcgc atccgggctt gccggattta 415141 ctcggttttg ggcgccgcaa tatggcgatt tctcctgagg aagcgtatga tcttgtcgtt 415201 tatcaaattg gcgcgctctc tggctttcta aaagcagagg gacttcacat gcagcacgtc 415261 aagccgcatg gcgctttata caatatggcg gcagtcgatc aaaaactgtc ggatgctatc 415321 gcgaaagctg tctataaggt tgatcccggc ctgattcttt tcggtcttgc tgagagcgag 415381 cttgtaaaag cgggagaacg gatcggactt cagaccgcaa atgaagtgtt cgccgacaga 415441 acataccaat cggacggcac gctgacaccg cgctcccagc cggacgcact cattgaaagt 415501 gatgatgccg ccgtcaccca ggtcatcaaa atggtgaaag aaggggcggt caaatctcag 415561 caaggacatg atgtgtcatt aaaagcagat acagtctgca ttcatggaga tggagcccat 415621 gcgctgacat ttgcgcaaaa aatcagaaaa cagctcaaag cggctggaat tgaagtgaca 415681 gctatttcag aacagaggtc aacataaagg aggaacaata gatggagcag cagaaaaaga 415741 cagcaggaaa aaaagcgggc agctggtcat tgctgatggg cgccgccttt ttaatggcga 415801 catcagcaat cggaccgggt ttcctcaccc aaaccgcaac attcacaaac acactcgcag 415861 caagcttcgg ttttgtcatc ttaatctcta ttattttaga tattttcgcc caaaccaatg 415921 tgtggcgcat catcgcagtt tctggaaaac gaggtcagga aattgcgaat atggtgcttc 415981 ccggactggg gtatttcatc gccattctcg tcgtgcttgg cggactagct tttaatattg 416041 ggaatatcgg aggggccggg ctgggacttc aggtgctgtt cggcattaca cctgaaacag 416101 gcgctttaat cagtgccgtt atcgccattt tgatttttgt catcaaggaa gcaggaaaag 416161 cgatggaccg ttttacgcaa atcgcggggt tcgtgatgat tattttaacg gtctacgttg 416221 cggcgacgac agctcctccg gtcggacagg cagtcgcaaa tacattcgtc ccggaacaca 416281 tcagcatatt tgccattgtc accctagtgg gcggaaccgt cggcggttat atcacatttg 416341 ccggaggaca ccgtttgctt gatgccggaa ttaaaggaaa ggaatccatt ccgcaggtga 416401 caaagagctc ggttgtcggc attttaatta catctgtcat gcgtatcgct ctttttcttg 416461 cggttctagg cgttgtatcg aaaggcctgc acatcgatga aagcaacccg gcggcttctg 416521 tcttcaagct ggctgctgga aatgtcggtt ataaaatttt cggattgatc atgtggtctg 416581 cggcgattac gtctgttatt ggagcagcct atacatctgt ttcatttttt aaaacctttt 416641 ctccaaaaat tgaaaagaat tcacgcggta ttattatcgg atttattgtg gtttctacgt 416701 tagcttttgt cacaatcggc cagcctgcga agatcctcgt ccttgtcggt tcactgaacg 416761 gcttaattct gccgattgcg ctcggaacgc tgcttgttgc cgcctacaag aaaaacattg 416821 tcggtgatta taagcatccg ctttggctga caagcacagg cgcgcttgta gtgattgtaa 416881 tggcagttat gggaatctac acgttatgta cacaacttcc tcaattgtgg agctgatata 416941 agtggagcaa ttaaacaaaa tggcgccaaa ggatgtacgc gccctgatac gagaggggaa 417001 aataaacggg ccgaccgcag gcatgtccgg cggctacgcc caagcgaatc ttgtggtttt 417061 gaaaaaggac cttgcgtttg attttctgct gttttgccag cgaaatcaaa agccctgccc 417121 cgtgctggat gtgactgaag caggttcgcc tgtgccgtct ctggctgcgc cggatgctga 417181 tatcagaacg gactttccga aataccgtat ttacaggcac ggtatcctaa cggaagaagt 417241 atctgatatt acgccatact gggaggacga ttttgtcggc tttctgatcg gatgcagttt 417301 ctcctttgaa caggcactga tcaataatgg gatagctgtc cggcatattg atgaggggac 417361 aaacgtctca atgtataaaa cgaatatcga ttgtgttccg gcgggggcgt ttcacggaca 417421 gatggttgtc agcatgaggc cggttcctga acggctggct gtacgtgctg cacaagtgac 417481 ctcgcgtttt ccggctgtgc acggagggcc gatccatatt ggcaatccgg gagcaatcgg 417541 gattcgcgat ctcgggaaac cggatttcgg agatgccgtt tccattcgtg acggcgaggt 417601 tcctgttttt tgggcatgcg gagtgacccc gcaagccgtg gctatgaatg taaagcctga 417661 aatggtcatc acacatgcgc cggggcatat gctcatcaca gatattcgag acgagtcgct 417721 tgcggtgctg tagcctctcg tcatcctgat gaacgagaat taaaagaggt gagaaagatg 417781 actgtacgat atcaaatcga acagctcggt gattctgcaa tgatgatccg attcggagaa 417841 gaaatcaatg aacaggtcaa cggcattgtc catgcagcgg ccgcttatat agaagaacag 417901 ccatttccgg gattcattga atgtatcccg gcttttacaa gtctaaccgt attttatgat 417961 atgtatgaag tgtacaagca tttgcctcaa ggcataagct caccttttga gagtgtcaag 418021 cgcgatgtcg aagagcggct ggcagaaata gccgaagact atgaggtcaa ccgccgtatt 418081 gtagaaattc ccgtttgcta tggcggtgaa ttcggtccgg atttagaaga ggtggcgaag 418141 atcaatcaac tgtcaccgga ggaagtaatc gacattcata caaacggtga atatgtggtg 418201 tatatgcttg gcttcgcgcc cggttttcct tttctaggcg ggatgtcaaa acgcattgca 418261 gctccgagaa aatcatcgcc aagaccgtcg attcccgcag gttcggtcgg tattgcggga 418321 ttgcagacag gcgtttatcc gatttcaacg ccgggcggct ggcagctgat cggcaaaacg 418381 ccgctggctc ttttccggcc gcaggaaaac ccgccgacat tgctgcgggc gggagatatt 418441 gtgaaattcg ttcgcatctc agaaaaagac tatcacgcct ataaggagga gtccaattga 418501 gcatgaaagt attaaagccc ggactgctca caacggttca ggatataggc agaacgggtt 418561 accaaaaata cggcgttctg gccagcggcg ctatggacac ggtttcactg cgcattgcca 418621 atctgttgat aggaaacggc gaaaatgaag caggtctcga aataacgatg atggggcccg 418681 gtccgtcgtt tcatttttca aaacagacac tgattgctgt gacaggggcg gacttcacgc 418741 tgcgtattaa tgacgaggaa gcgcctttat ggaagcctgt gctcatcaag gaaaacagca 418801 cggtcagctt tggcccctgc aaactcggca gccgtgctta tttggcggca gctggcggca 418861 ttgaggtgcc tgccgtcatg gaaagtaaaa gcacatacgt cagaggaagc attggcggac 418921 ttcatggcag agcgcttcaa aaagaagatg aactgaacat tggagagatg tcagctcttt 418981 cgcaaaccat cctttctcgc ttaagttcgc agcttggaaa acagggattt gcagcaccga 419041 agtggtcagt cagccgcggc agatttctgc cattgaagaa gaatcccgtc attcgggtgc 419101 tggaaggaaa gcaatttgcc tttttcacag aagaatcaaa aacgcgtttt tatgaagaag 419161 catttcgtgt cacgccgcag tccgaccgta tgggctacag gctcaaagga gaaccgctcg 419221 aactgaaggc cccgcttgag atggtgtcgg aagcggtttc attcggaaca gttcaggtgc 419281 cgcctgacgg caacccgatt atcctgcttg cagaccggca gacgactggc ggctatccga 419341 ggatcgcgca catcatatcc gctgatcttc cgattgtttc ccaaatcatg ccgggcgagc 419401 acgttcagtt tgagcctgtg tccctccagg aggcagaagc gcttgcggta gaacgggaac 419461 agcatataaa agaactgaaa acgagaatga agatggaatg gctgacatag caaaggggat 419521 gaatgatgca gaataaaaat aaaaccgtag tcaaatctat ggcgctgctt aatttgtttt 419581 tgcataaacc aagcctaacc ttaagtgaac tggtgtcgct gacgggaatg ccgaagacct 419641 ctgttcaccg gatggtcagc tccttggagg aaatggggtt cctcagtcgg gatgcgtccg 419701 gcgcttattc gctgggattg gtgtttttgg aattcggaca gcttgtcgct gacaggctgg 419761 atatcagaaa aatagcgaaa ccggtgatgg aagagctgtg ccgggaagtg gatgaggccg 419821 tgcagttgat catgagggac ggcaatgaag cgatatacgt tgagaaaata gaagggacac 419881 agactgtgcg gctgtatacg gcgatcggca ggcgttcccc cctatacgcg ggagcgtgcg 419941 ccagaagcat tctgtccttt cttccccgtg aagaaatcga agcatacatc aaacaaaccg 420001 agctcatttc gattggctcc ggaacgatta ccgatcccga aaaactgctt caggagattg 420061 atgcctctgt gcaaaatggc tatactgtca gctattcaga gctcgaaaac tatacggcgg 420121 cgatcggcgc cccgatcttt aaccatgagc gccaggtggc agccggcatt agcattgcag 420181 gctttgaagc gagatttaca gaagacaggc tgccctattt aacagaaaag gtgaaggacg 420241 ccgctttaca gatttcaaga aaaataggat atacataagt agccaatctt ttctctgctg 420301 cgtacattaa cgtatcgacg ttcaagagtg gaggaaagaa catggtgctt cgatatacag 420361 ctctgggcga ttccttgacg acagggagag gctccgggct gttttcaccc ggcttcgtcc 420421 agcgttttgg ggacatgatg gaagctgact tgaaaacaag aacggcaata aacatatttg 420481 ccagatcagg tctgaataca gaagagattt tgggactcct gtcatatccc tatgtgcaaa 420541 aatgtattcg agatgctgat atgataacga tcacagggtg cggaaacgat ctcatcgatt 420601 cggtcttagc ctaccaaacc tctaaggatg aaacgatttt cagccgtgta tccgcccatt 420661 gccatgagaa ttttgaaaag atgattgcca aagtcgccga gattaaagga gaaaatcctt 420721 ccccgtacgc cattcgtgtg ttcaacttat acaatccgtt tcccgaaatt gatatcgccg 420781 gcaaatggat cacttcgttt aattcacatt tagaaacact tgcatcagca ccccatgtca 420841 aaatcgcgga tgcctatagc atcttcaaag gcaaagaaca ggaatatctg tcctttgacg 420901 gtgtccatcc gaacagcaaa ggctatcaag cgatggctga agccgttcac aagctaggct 420961 ataaagaatt atcagtttca tagaaaacgc gcctcatgac aggcgcgttt tttatgtgtg 421021 atcgaaatat taaaagaaac ttaaaattct ctgtcttctg ttctacagac aaacaaagtg 421081 cgctagaata atggagggcg taggcaaata tagccataac gttcaatatt tcgtatataa 421141 ggaaggatgg tccttttgtt tcggattttt aaaatgtctt ttgcggttat cattattata 421201 ctggcgctta ttgcttttaa ctatacggaa cacacctctg taatccaatc ggtcatgctc 421261 gtctttcttg gtgcggtcat gtttatgcag gggcttgaag agcgcaaaaa agaaaatgac 421321 ggctcaggcg cttttaatat ttataccgcc gtttttgtat ggtctgtctc ccttatcggt 421381 tttacacttc atattatata aatctattac acatcctgaa aatgctcgac cgtcgggaac 421441 ggggtataga accgatgaag caaggctttc cactcttgat actctgaaga accgcgaaag 421501 ccttccgtat ggtcctcaag tgtttcccac tccacaagaa gcagatattt atgcgtttcc 421561 tccatgcatt ttgataacga gtgagtgata tagcccttca tgccggaaat aatcggcgca 421621 gcttgccgga atgcatcctc aaactcttgt tcaaggcctt ctttaatgtg aagcattgct 421681 gcctctctga ccatgctatc ccttctttct gtcttttcaa atagtctaca gcaaacgata 421741 ggagatttct gcaaaatcgg tgaacttttc cttcattttc aaaaaaatct tgcacgcacc 421801 aattcaatta agagaaaata acaagtggaa ggcaggggaa agtcatgtta aaaaagtgta 421861 ttctactagt atttctatgc gtcggattga ttgggttaat cggatgctcc aaaacagatt 421921 caccagagga tcgcatggaa gcattcgtga aacagtggaa cgatcagcaa ttcgatgaca 421981 tgtatcaaag cctgactaaa gatgtcaaaa aagaaatctc caaaaaagat ttcgtcaaca 422041 ggtataaagc catctatgag caggccggcg taaaaaattt gaaagtcact gcgggagaag 422101 tagataagga cgatcaagac aacaagacga tgaaacatat cccgtataaa gtcagcatga 422161 acacaaatgc cggcaaagtc agcttcaaga atactgctgt gctgaaatta gaaaaaacag 422221 atgacgagga gtcatggaat atagattggg acccatcgtt tattttcaag cagctggctg 422281 acgacaaaac cgtgcaaatt atgagcattg aaccgaaacg aggccaaatt tacgataaaa 422341 atggaaaagg cttagccgtc aatacagatg ttccggaaat tggaattgtt cccggagagc 422401 ttggcgataa aaaagagaaa gtcataaaag aactcgccaa aaaacttgat ttgactgaag 422461 acgacatcaa gaaaaagctg gatcaaggct gggtaaaaga cgattcgttt gtgccgctca 422521 aaaaggtcaa gcctgaccag gagaaattag tttctgaagc gacgtcatta caaggcgtaa 422581 caagaacgaa tgtcagctcc cgctactatc cgtatggcga aaagacagcc catttgacag 422641 gctatgtccg cgccattaca gcggaagaac tgaagaaaaa gaaagaagga acgtacagcg 422701 atacgtctaa catcggtatc gccggacttg aaaatgtgta tgaagacaag ctaagaggca 422761 caactggctg gaaaatctac gtgccgcaaa ccggggaagt catcgctgaa aagaaagcaa 422821 aggacggcga ggatcttcac ctcacaattg atatcaaaac gcaaatgaag ctgtatgatg 422881 aactgaagga tgacagcggg gcggcagtcg cgctgcagcc gaagacaggc gaaacactcg 422941 cccttgtcag cgcgccttcc tacgatccaa acggatttat tttcggctgg agcgataagg 423001 aatggaaaaa gctaaacaaa gataaaaaca atccgttttc agcgaaattc aataagacat 423061 acgcgccagg ttctaccatt aaaccgattg cggctgctat tggaatcaaa aacggcaccc 423121 ttaaagccga tgagaagaaa acaatcaaag gcaaggagtg gcaaaaagat tcaagctggg 423181 gcggctattc agtgacacgt gtgtctgaga gacttcaaca agtcgatttg gaaaacgccc 423241 ttattacgtc agacaatatt tattttgccc agaatgcgct tgatatggga gcggacacct 423301 ttacaaaagg cttgaagaca ttcggttttt cagaggacgt tccgtacgaa ttcccgatcc 423361 agaaatcgtc tattgcaaat gacaagcttg attcagacat tttgcttgcg gatacaggct 423421 acggacaagg gcaaatgcaa atgtctccgc ttcacttggc aactgcttac acgccatttg 423481 ttgacaatgg agaccttgtc aaaccgacgc tgatcaaaaa agattcacaa acagctgatg 423541 tttggcacaa gcaagtggtc acgaaggaag gagcggcaga cattacaaaa ggtctgaaag 423601 gcgttgtgga agatgagcgc ggatcagcgt atcagcctgt cgtgaaagga atcacagtgg 423661 ctggaaaaac aggaacagcc gagctgaaaa catcaaaaga tgataaagac ggcacggaaa 423721 atggctggtt tgtcggctac gattacgaaa acaaagacct gcttgtcgcc atgatgatcc 423781 aaaatgtgca ggaccgcggc ggcagccact atgtcgttga gaaagcgaaa aagcaatttc 423841 aatcgaatta aaatgtcttt ttaaaaggag cgaaaggaaa aaggggatct gaggccgaat 423901 gaactagtaa gggggcaaaa cccggtttat acaaagaaaa gagggatttt gcatgcagcg 423961 tattcaattg gcggaggatc ttcaattttc aagagtcata cacgggcttt ggcggctgaa 424021 tgaatggaac tattcagatg ctgaacttct aagcctcatt gaatggtgta tcgatcacgg 424081 catcacgacc tttgatcatg cggatattta tggaggctat acgtgcgaaa agctgtttgg 424141 aaacgccctt gccctttcgc ctggattaag agaaaacata gagttggtca caaaatgcgg 424201 tatcgttctt gaatcgcctg aacggcccgc tcacagatcg catcattata acacaagcaa 424261 atcgcatatt ttggcatccg ttgagcaatc gcttatgaac cttaggacgg attatatcga 424321 tatgcttttg attcacagac cggacccgct catggatccg gagggggtag cagaggcgtt 424381 tcaggccttg aaatgctctg gcaaggtcag gtactttggc gtttcaaatt ttaaagatca 424441 ccagtatcgg atgctggaat catatttgcc tgagaagctc gtaaccaacc agattgagct 424501 ttccgcatac gaattagaaa atatgctcga cggcactttg aacctgtgcc aggaaaaacg 424561 gattccgccg atggcttggt cgcctctggc aggcggcaaa gtattcactg aaaacacgga 424621 taaagaccga cgtgtccgta cggcgcttga atccgtccaa ggggaaatcg gcgccgcttc 424681 attggacgag gtgatgtacg catggctgta tacgcatccg gccggcatca tgccgattgt 424741 cggaagcgga aagcgcgagc ggatttccgc cgcgataaat gcgttgtcat acaagcttga 424801 ccaggatcaa tggttccgca tttttacagc cgtacagggt tacgatattc cataaaaagc 424861 atcagtttac cagctgatgc tttttcaata ttgtcacacc gcttagtgcc aaattaccat 424921 ttataagtga ttgattcttt cttgaaagcg ttttatatta aaaggaaacc tctctatatc 424981 ctctactgca tctccttgcg acttcatccg cacatcaaga ttggctagga ggtctttttt 425041 atgtatatga ctgccagaga acaaaagctg ttaaagcact tattattaca aaacagatat 425101 ataaccgtaa ctgagcttgc tgagctgatg caagtcagca cgagaaccat tcacagggaa 425161 ctcaaatcaa ttaaaccgct gatggaaacc gtggggctta cgttagataa acagcccggt 425221 aaagggttga aagcagtggg aagtcccgag ggtaaacaaa agctgcttac tgatttatca 425281 tatgaacagc atgaatacag cgccgacgaa cggaaactgc tcattctttg ttcgttatta 425341 gagtctcagg agcccgtcaa actgtacacg cttgctcatg atctccaggt gacgaatgcc 425401 acggtcagct atgacttaga tgagctcgag aagtggattt ctccctttgg actgacactg 425461 atccgcaaaa gaggttttgg catccagctc atagggccgg agaatgcgaa acggaaaatt 425521 gtcggcaact tgattgtgaa ccgtctcgac atccaaatgt ttttggaagc ggttgaatta 425581 aacatcaaag gaaaaaccga ttcttcagag aaaatgttcg gggttgtcag caaaggtgag 425641 ctgttaaaaa tggagcgcat cttatttcag ctcaaagaaa aaatcgcttt ttcattgtcc 425701 gacagctcct atatagcgct cgtcgtccat ctgacgtatg cgatcgaacg aattaagctt 425761 ggggaaacta tcaccatgga gcaaaatgag cttgaggaac tgatgaatgc gaaggaatac 425821 agctccgctc ttgaaatcgc gggcgagctt gaacgtgcct tcggcgtgac gattccagag 425881 gcggaggtcg gctatattac aatccatctt cgaagcgcca atcgaaaata caaaacagaa 425941 tacaaagcgc aggaaattga gctggaaaca gccctgcaaa caaagcggct cattgctttt 426001 atttcagaca aaatcagaat ggatctgacg aaaaactact ctttatatga aggcttgatt 426061 gcccatttgg agccggccgt cagccgcata aaagaaaata ttgagatata caatccgatg 426121 aaggaacaga tcaagcgcga ttattttctg ctttatatgg cgatcgaaga aggtgtcgaa 426181 aagtattttc cgggcatgtc cttttctgat gatgaaatcg cttttatcgt tcttcacttt 426241 ggctcggctc ttgaaatcaa aaaagaagaa gcaaaagtga aagcgcttgt cgtctgctca 426301 agcgggatcg gctcctcgaa aatgcttgcc tccagactga aaaaagagct gccggaaatt 426361 gaatcgtttg atatgtcatc tctgatcgag ctaaagggga aggatgttca agcctatgat 426421 atgattgtgt ccactgtacc gattccttat gaaaacattg attacatcat ggtcagccca 426481 ctattaaatg aggaagacgc aaaccaggtc aagcagtata tcaagcggaa gattcccctt 426541 attcttaaca aaaaaagaag ctcgaaggaa gaggcgcagc aagctgatgt acctgacatg 426601 ctggaggcgg cggaaagcat agggcggtat atggaagtta tccaagatgt tctgcgccat 426661 tttacgctag ctcaactcaa aacaaacccg gaccatagca tgcttctgct agagcttttt 426721 caacagctga agaaggatgg cctgatccgt gatccggaaa aagccgcggt ttgcctggct 426781 gagcgggaga aacaaggggg attgggaatc cccggaacaa acatggcgct ttatcatctc 426841 aaaaatgatg aaatcgtcct gccttttttc aaaatgtttg atctcagcac cccctatgaa 426901 gtggatggca tggacggaaa taccctcagg atgacacgca ttctcgtcat gatggcgcct 426961 ggctcattat ctgctgaagg ctcggagatt ttaagcgcga tcagctcggc aattatcgag 427021 agcggagaaa gcatggcggg gtttcaggaa gaaggaggac aagaattgta tcagcggtta 427081 aaccgcatat ttttcacatg gatgaaagaa aaaaacatac tgtaaacctg catggcacac 427141 gtcaaaaatt tggcgtgtgt ttttctgtgg atggggaaca aaataagaaa atgtgggact 427201 attttatcat tcagtattgg aataattcca aaatgaaata gttttacaag ttatcttttt 427261 tgggttaaaa tgggtgaggt aaggaagaaa atctaacaaa ttattgaaga ttcaagagaa 427321 tataggagat gacgatatgg aaacattaca gcatctgatt ctgcatgaca tgccgaatag 427381 cgaagaaata gaggctgtaa aaagcggaga ccatacactg acatataaag gttaccgtaa 427441 acggattaat cagctggcga atgccatgct tcaaaaagga attcaaaagg gcgaccgtgt 427501 tgcattgctt tgcaaaaacg gccatcccgc ctcaactgtt atgttcgccg cacttgaaat 427561 aggtgctgtt gtcgtacctg tcagctggca gctgaaacca tatgaaatga caggcatttt 427621 aaaagcaagt gaaccaaaag cgatgtttta cggagcggag tttaaagaga tactggatga 427681 agttcttcct gaattgtcct cactgtgtgt aacaatggaa acaggaacag cttacgaaac 427741 atctgctgaa tttgaagcgc tgtttgcagg tcctgatcat ttgccagaga cggaaatggt 427801 ttcacctgat gatacagcac ttctgatgtt tacatctgga acaacgggaa acccgaaaag 427861 atgcatgatt acacatggcg gcatatacag atacgttaaa aaatccaaca gctcaatagc 427921 acgtatgaag ggccttcgtt ttctcgcgtg ccatccgatt tatcatacga gtgcgctcat 427981 ttgcatcatg cttggaacgt ttgcagaaac aacatttgtg tttacaaagg atcaagatcc 428041 tgttcacatg ctgaaggtca ttgaagaaga gaagattcag accgtgatgg ctcttcctgt 428101 gttctacacg tatttgcttg aggcgtggga aaagcaccaa actgacttat cttcgcttgt 428161 tattttaatg acaggcggaa caaaagtgcc gagcagccta ataagccgct atcttgatat 428221 tggcattccg cttgcgcatg gctatggaag tactgaggct tggggcatca gcacatggac 428281 gcctgatatg ggaatggata aagcggcatc tgcaggaaaa cctgtggcag gtgttaaagt 428341 caaagtggaa gatcctctga ccggagaaga acttcctcaa ggagaaatcg gcgaaatcgt 428401 tgttcatact ccattcttat ttaaaggcta tgaagacaat cctgaagcaa cagcgaaagt 428461 gctgcaaaat ggatggttta gaaccggaga ttcaggatat gtagatgaag atggctttat 428521 tttcatcacg ggacgctaca aggatgtcat tatttacgga ggcgataacg tctatcctga 428581 tcaggttgaa gaagttatcc agcagatccc gggaatcctt gaaacggctg tggtcggtat 428641 tcctgacccg ctttacggtg aaaaaccgaa agcttttatc gtgaaaaatg gcggccagcg 428701 catcacggaa gaggatgtca tcgcattttg taaagaacgc ctgtccgctt acaaaatacc 428761 tgaagttgaa tttgttaacg aactgccgaa aaacaacctt ggcaaggtga aaaaagacgt 428821 cctgcgcaat caggctgtac attcataaaa gaagaagccc gtccacttta tgtggcgggc 428881 ttctttgcag ttgcacagac ggaaagctca ggcttaatgt tcttaaattg tatatcaatg 428941 tcttcgaagc cggctgcttt aaagtcagca atcatctgtc ttccaaatga tttggttttc 429001 tcaggactgg catccgcttc ccgcggctgc atcgtaatgg ctgctttgcc gcctggcttt 429061 aatgcccgat aaatctgttt tatgcctttt gtttggtcat tccaaatggt gtagttgtta 429121 acggaaatca ctttatcata aaacgaggcg gggagaggaa atgtctcgat gcttccttgt 429181 atcaggcgta cgccctttgg tttcactctg cgggcggcca gcttcagcat ggcctctgat 429241 acatcaatcc catgaagatg aacatccttc tcgcgtttca gcatctgctg catgcagtat 429301 cccgggccaa acccgacttc taaaatgctg tccccgcgcg tgatacccag ctgattgatt 429361 gtccactgat tcagtgtttg attttcagca gccatgatgt acccggcaat catgccgatg 429421 acgccctttg gcctgctgaa tcttctagaa agcatgttaa tcattcagca accaaccccc 429481 tttttgagtt aatttcctct cagcgttcca tgtgaaacat ttttctgata aagcaatgcg 429541 aaggtgccaa gccatgttta tccaaagagt gtgtgaggta cacaacaaat agacatgaaa 429601 acaaaggagg agaatcatca tggcaaatta tccaaaagaa ctgccggcac aaactcaaag 429661 tcgccagccg ggaattgaaa gcgaaatgaa tccaagtccg gtgtatgagt acgaggatta 429721 taaaggagca gacaaattaa aaggaaaagt agctcttatt acaggcggcg acagcgggat 429781 cggacgcgcg gtttccgtcg cttacgcaaa ggaaggcgca gacatcgcca ttgtgtataa 429841 ggatgagcat gaagacgctg aggagacgaa gaaacgtgtt gaacaagaag gcgtaaaatg 429901 cctgctgatt gctggtgacg taggtgaaga ggaattctgc aatgaagcgg ttgaaaaaac 429961 ggtcaaggaa ctaggcggcc ttgacatcct tgtcaacaat gcaggtgaac agcacccgaa 430021 ggaaagcatc aaagatatta cgagcgaaca gcttcaccgc acattcaaaa caaattttta 430081 ttctcaattt tatttgacta aaaaagcaat tgattacctg aaaccgggca gcgccatcat 430141 caatacgaca tccatcaacc cgtacgtagg gaacccgaca ctgattgatt atacagcgac 430201 aaaaggggcg atcaatgcct ttacaagaac aatggcgcag gcgcttgtca aagacggcat 430261 ccgtgtaaat gcagtcgcgc cgggtccaat ttggacgcca ctaatcccag ctacgttccc 430321 tgaagaaaca gttgctcaat ttgggcaaga tacgccgatg ggccgtcctg gacagcctgt 430381 tgagcacgtc ggctgttatg tgcttctggc atcagatgag tcctcttaca tgacaggtca 430441 gaccctgcat gtcaacggcg gaaactttgt gacgacataa gagggagtga gacatatggg 430501 catcacgaaa gaagaagtga acagctacta tcaaaaagca gggattgtat taacggacga 430561 ggaagtagac caaatccagc tgatggatta cggcttagga aaagaaagaa aagtcgggct 430621 ccagctcttc gtctacgtca atacagaccg ttattgttca aaggaattgg tgctgtttcc 430681 gggacagact tgcccggaac accgccatcc accggtcgac ggccaggaag gcaagcagga 430741 gaccttccgc tgccgctacg gaaaagtgta tctttacgta gaaggagaaa aaacgccgct 430801 tccaaaagtt ctccctcctc aggaagacag agaacactat acggtctggc acgaaattga 430861 gctagaaccg ggcgggcaat acacgattcc accaaacaca aagcattggt tccaggccgg 430921 ggaagaaggt gccgtcgtga cggaaatgtc atcgacgagc acggataaac atgatatctt 430981 taccgatcca agaatataag gatgggctta acagcccatc ctttttgtat tgaaaaaaac 431041 agaatcatcg ctataatggg taaaaaagga aagagggcga ggcaatgttc acttgcaagg 431101 taaatgagca catcaccatc cgattattgg agccgaagga tgcggagcgg ctggccgaac 431161 tcattatcca aaatcagcag cggcttggca agtggctgtt ttttgcggaa aatccaagca 431221 gcgctgacac gtaccgagaa acaatcattc cagattggcg gcgccagtat gccgacctga 431281 acggcattga ggcgggtctc ctttatgacg gcagcctatg cggcatgatc agcctgcata 431341 accttgatca agtgaatcgt aaggcggaaa tcggatattg gattgccaaa gaatttgaag 431401 ggaaaggcat tattacagct gcctgccgaa aactcattac gtatgctttt gaagagcttg 431461 agctgaatcg tgtggcgatc tgtgcggctg tcggaaacga aaaaagcaga gcggttccgg 431521 agcggatcgg gtttctagag gaaggaaagg cacgggatgg cttatacgta aacggcatgc 431581 atcacgacct cgtctactac agtctgttaa agcgtgaatg ggaaggcgaa aaataaagag 431641 cacactttct tgtttaaatc ttccccggat gtggaaaagt aacagcggag acgttaaaaa 431701 ggagtgattc gagatgaatc agcaagacat taaacaaaaa gtgcttgatg ttctagatca 431761 ccataaagta ggttcgctcg caacagttca aaagggcaaa ccgcattccc gctacatgac 431821 ttttttccat gacgggctga cgatttacac accgacaagc aaggaaactc ataaagcgga 431881 agaaattgag aacaacccca atgtccacat tttattaggc tatgattgtg aaggttttgg 431941 cgacgcatat gtcgaagttg ccggaaaagc aaagatcaac aattcggcag aactcaagga 432001 caaaatatgg agttccaaat tagagcgctg gtttgacggc aaggatgatc cgaatctggt 432061 gattcttgaa attgaaccgg aggatatcag attaatgaat gccggggaga aaacaccggt 432121 ctcactcgaa ctataaaaaa tttgtgtttt caggggcgat atgttattat gaatagctag 432181 taagaaaaat aagcaaataa aaaagaaagt aaacttcttt tttctgtttt gagagagaag 432241 cttaccgctt cccaagcagc ataaccagct gcccttattc ttttccttca taacaaatcg 432301 cccctaacga tgagatggaa aaaagacttt tttgttttac aattcacacc ggcgcggctt 432361 cggagccgca gtgacgattg agaggtaggg ctttcgttgt cttgtgttca agaaatttcc 432421 atggtgttta ctttccagaa tgattcttcg gaacaatgct ttatgaatct aacccgcctg 432481 acttggcgga tgatataatc tttatttgcg tatagaaaag aataagacaa accgcccggc 432541 gtacgccgga cggttttttt attgcaaaaa acacatcgta ctgaaacctc cttgtcttct 432601 ttccagtctt atctctagga tgaaattgga ggaagaataa cgtgcatgtc attacaacac 432661 aagtactttt tattttttgt tttttattgc tgattcactc gatagaaacc ttagcctatg 432721 cgacaaggct ttccggagct cgcgttggat ttattgcgtc cgcgctttct ctgtttaatg 432781 tcatggtcat cgtatccaga atgtcgaata tggtgcagca gccctttact gggcatttaa 432841 ttgatgatgc tggaaaaaac gcactggcga ttgtagggga gcagttccgc tttttaattt 432901 tcggatcgac agtcggcacc attttgggca ttatcctgct cccgtctttt gtcgctcttt 432961 tttcacgggc gattattcac ttggcgggcg gcggcggctc cgtttttcaa gtattccgaa 433021 agggattctc gaaacaagga ttcaaaaatg ccctttccta tttgcgtctg ccgtccattt 433081 catatgtaaa aggatttcat atgcgcttga ttccgaagcg tttgtttgtc atcaacatgc 433141 tgatcacatc gatttatacg attggtgtgc tttcggcttt atacgcaggc cttttggcgc 433201 cggagcgcag cacgacagcc gtcatggctt cgggtttgat caacggaatt gcaacgatgc 433261 tgctggctat ttttgttgat cctaaggtat ccgttcttgc tgatgatgtg gcaaaaggaa 433321 aacgaagcta tatctattta aaatggacct ctgtcacaat ggtcacatca agggtggcgg 433381 gcacactcct cgcccagctc atgtttattc ccggggccta ctatatcgcg tggctgacaa 433441 agtggtttta ataagaaagg ctggatcata aagatccagc ctttttgcgc ttccttattt 433501 atagttcctt aatccgcggt cgtacaaaaa atttccgaat gggacgaaag cggcgatgaa 433561 gccggcagct gaccatttca gcggccattt gacagagaag gttgcataag ccaagacaag 433621 caaatacaaa atgaacaacc cgccgtgaac cgaaccgaca attgtcaccg caagcggaag 433681 gcctgcccaa tatttaagcg gcatagcgat gaacaacagg attaagagtg acattccttc 433741 aataaaaccc atcgtgcgaa gtcttccgat cggcgtgtgc agcataaatc gccctccttg 433801 tggacacgtt ttcattttat actataaaca atccgggggg gcatatgaca gctttcaaaa 433861 aatgttcgga aaacattcat ttttacatgc cttttctagg gaactgtact tgtcatttac 433921 aaaaataccc gagataatgt gtacaaaatc aaaaaagaag gatgttgaaa tgaaacttga 433981 ccagattgat ctgaatatca ttgaggagct gaagaaggac agccgtttgt cgatgaggga 434041 attaggcaga aaaattaagc tgtcgcctcc atctgtaaca gaacgggtaa gacagcttga 434101 atcgtttggc atcatcaagc aatacacgct ggaggtcgac cagaaaaaac tggggcttcc 434161 cgtttcctgc attgtggaag caaccgttaa aaacgcggat tatgagcggt tcaaaagcta 434221 tattcaaaca ttgccgaata ttgaattttg ctaccggatt gcgggtgcag cctgctatat 434281 gctgaaaatc aatgccgaaa gcctcgaagc ggtagaagat ttcattaaca aaacatcgcc 434341 ctacgcgcaa accgtcactc acgtcatttt ctcagaaatt gacacgaaaa acgggcgcgg 434401 ttagagagtg ccgcgcgaag tctgttataa taacaggatg agcgtgaaag aaagagaagt 434461 gatcaagcat gtcaaaaaca gttgtattag ctgaaaaacc ttcagtcggc cgggatttag 434521 cccgggtact gaagtgccat aaaaaaggaa acggttatct cgaaggcgat caatatattg 434581 tgacttgggc tttaggccat ttggtgacgc ttgctgatcc ggaaggctac ggaaaagaat 434641 ttcaatcatg gcgcctagag gatctgccga ttatcccaga acccttgaag cttgtggtga 434701 taaaaaaaac cggaaagcag ttcaatgcag tcaaatccca gcttacccgt aaagacgtca 434761 atcagattgt catcgcgact gacgcaggcc gggaaggtga gcttgttgcg cgctggatca 434821 ttgagaaagc gaatgtccga aaaccaatca agcggctgtg gatttcatct gtgacggata 434881 aagcgatcaa ggaaggtttt caaaagctgc gcagcggcaa agaatatgaa aacctgtacc 434941 attctgccgt cgccagagcg gaagcggatt ggattgtggg gatcaacgcc acccgtgcac 435001 ttaccacaaa attcaatgcc cagctctcat gcgggcgtgt gcagactccg acgcttgcca 435061 tgattgcaaa gcgcgaggca gacattcagg cgtttacgcc cgttccgtat tacggcatac 435121 gtgctgcagt cgacggcatg acgctgacgt ggcaggataa gaaatcaaag cagacgagaa 435181 cgttcaatca agatgtaaca agccgtttgc taaaaaatct ccaaggaaag caagcggtcg 435241 tagctgagct gaaaaaaaca gcgaaaaaaa gctttgcgcc tgcgctttat gatttaacgg 435301 agctccagcg tgacgcccac aagcgcttcg gtttttctgc caaagaaacg ctttctgtcc 435361 tgcagaagct atatgagcag cataagctcg tcacatatcc gcggacggac tctagatttt 435421 tatccagtga catcgtcccg acgttaaaag accgtctgga aggcatggaa gtaaaaccgt 435481 atgcccaata tgtcagccaa attaaaaaac gcggcattaa atctcataaa ggatatgtca 435541 atgacgcgaa ggtgtcagac caccacgcga ttatcccgac cgaagagccg ctcgttctca 435601 gcagtctgag tgataaagaa cgaaagctgt atgacctgat tgcgaaacgt ttcctggctg 435661 tattaatgcc tgcattcgaa tatgaggaaa caaaggtcat cgcagaaatc ggcggagaaa 435721 cctttacggc gaaaggcaaa accgtgcagt cgcaagggtg gaaagccgtt tatgatatgg 435781 cggaagagga tgatgagcag gaggatgaca gagatcagac acttcctgcg cttcaaaaag 435841 gcgacacact tgccgtccgc acgttaacgg aaacaagcgg ccaaacgaag ccgcctgccc 435901 gctttaatga agggaccttg ctgtcagcga tggaaaaccc aagcgcgttt atgcagggag 435961 aagaaaaagg cctcgtcaaa acgcttggag aaacaggcgg cctcggcacg gtggcaacgc 436021 gtgccgacat tattgaaaaa ctgttcaaca gctttttaat cgagaaaaaa ggccaagata 436081 tttttatcac atctaaagga aaacagctcc tgcagcttgt tccggaggat ctgaaatcac 436141 cggccttaac agcagaatgg gagcaaaagc tgtctgcgat cgcggccggc aaattgaaat 436201 cggctgtttt tattaaagat atgaaggctt acgctcacca aacggtaaaa gaaatcaaaa 436261 acagcagcca aaccttccga catgacaaca ttacgggaac ggcatgtccg gaatgcggca 436321 aaatgatgct gaaagtaaac ggcaaacgcg ggacgatgct cgtgtgccaa gatcgtgaat 436381 gcggaagcag aaaaacgatt gcccgaaaaa caaacgcacg ctgcccaaat tgccataaaa 436441 gaatggagct tcgcggccaa ggcgagggcc aaacctttgc gtgtgtgtgc ggtcaccgtg 436501 aaaagctctc tgtatttgaa aaacgaaaaa acaaagacaa agcgcgtgct accaaacggg 436561 acgtatcctc ttatatgaaa aaacaaaata aagatgagcc gattaacaac gcgctggcag 436621 aacagctgaa aaaactcggt ttggataaat aataaaaaaa cctgtgccta tcgcacaggt 436681 tttttattgg acttaggtcc tgttttctta atgttcaaaa agggaaaaaa aagctagcaa 436741 tctgcatttt ttttctttta tagtaaatgt actttgtaac atggcagtca tattttcgtc 436801 tataactatt tgtgagcgtc tgatttgctt caggcgacaa agggggattt gcctgtgagg 436861 catgtactaa ttgctgtcat cttattcttc ttatctatcg gactttccgc agggtgtgct 436921 gaagctggaa acaagaccca aaatcagtcg gcgacagaag tgaatgccag cccgctccag 436981 ccggcggaat atttcatcta tcacaattta atgaatgaca aagggctgat caaaaccgat 437041 ttttcagacc agccttctta cttgtcggaa tctctcggac tgtggatgga gtttctgctc 437101 agcaaaaatg acgcaccaca tttccaggat caatatcagc atctgactga ttcatttctg 437161 atgagcaatc acttggtgac gtggaagatt caaaatggcc aagcgagcgg gacgaatgcg 437221 ctgatagatg atatgagaat tatgctgtct cttgaccaag ccgccgcaaa atggggccgc 437281 agcgactacg cgcaaacggc tagggatatc ggcacgtctt tgaagacata caatatgaac 437341 aacgggtttt ttacagactt ttacgactca caggccgctt caaaggatgt gacgctttca 437401 tacgtcatgc ctgatgcctt agctgtctta aagaagaatg gaatcataga cgaagaaaca 437461 gaacagcgga atgccaatgt tctctattca gctcctttaa aaaatggctt tctgccgaag 437521 acatacagct cggagacgaa ggaatacaca tatgatagtg aaatcaacct gattgatcag 437581 ctttacgctg cttggcattt gccggaaggg gatgaaaaag catctgtttt agcggactgg 437641 atcaagcagg aatttcagaa aaacggaaag ctgtacgggc ggtattcggc atatacgaag 437701 gagcctgccg tccaatatga gtctccatcc gtatatgcct tagccgtatt gtttttgaca 437761 aaacagcatg aaaacagttc tgtcatcaaa gccatatatg atagaatgaa tgactttgaa 437821 attcatgatc cggtgaaatc gtattatgga ggctatatga gcggcactca gacgcattca 437881 tttgacaatc tgctgccgct gttagccgaa aggaagcttt ttaatgaaaa tatcattcag 437941 tgaatcacaa aaattatttg cttatttttc agggctcatc gcggccctgt ctttgtttat 438001 ttattatgtg tcagcccagc aatcagaagg tgctctgatc ctttgcatca catttggcgt 438061 catcgccgca ggcatctggt tcggcccgat ttacgcgctg gcagtgacct taatcgtact 438121 ctttgttctc ggcaccttaa tgatgttttt ccagactgga cagacatcgc tctttccggc 438181 tgaggaaggg ctgcgaatgc ttgtcgtgtg gggaatcgcg cttttgctgt tttcttttat 438241 ttctggaaga atccacgata ttacagcaga gcttcggcgc tcaatgacac ggcttcaatc 438301 cgaaattaaa agctatgttg ctgttgacag agtgactggt tttgataaca agcaaaggat 438361 gaagctggaa ctttcagaag aaatcaagcg ggcggagcgc tacggcaatt cttttgtgtt 438421 tttgctgctc catatgcatt atttcaaaga gtttaagtct ttgtacggtg aaaaagaaac 438481 ggaccgcctc ttccaatatg tcggtcagca aatcaggaca agcgttcggg aaacggataa 438541 gaaattccgt ccctctgacg agcgtatcgg gatcgtgctg acgcacacgc ctgctgaaca 438601 tatgccggcc gttctgacta agctgaagaa acaattggat acatatcagc tggaaaatgg 438661 aaagtatgtg tcgcttacgt tccacgtttg ctatttgccc taccgcaacg atatccaaac 438721 agctgatcaa tttttagaag aactggaaaa cgagatgatg atgaatgaac tataaaggaa 438781 tcacattgct atgcgtcatg atgcttctat tttcagctat tgcgtctttt cccgtttctg 438841 cgcaagcgaa agatcaggat gccggcattc tcatcatcta ctcaaccttg gacggcaaag 438901 agtcgtcaca agtcaaaatg ctcgatttgc ttgcgggcca ctttacatcc catgtgacag 438961 tcaaaaaaga ttcagacgtt gaagcgtcgg atttcaaagg gaaagaccat gtgatttatt 439021 acggccaaac gaaaagaaag ctcagccaaa aattgctgtc tcttatcagc ggcgtgaaaa 439081 aaccggttgt cgccattggc tataacgcag gccaaatcag ccaattttct gggctttcat 439141 tagcccgcaa agaaaatgtg tttcaggttc acagcaggtc agaaaaggcc gatgtgtctc 439201 tggaaagcgg gcttaacgtg ctgagtgtat caggcctgaa aggaacggcg ctttacacct 439261 tcaaagcgga tgaaggcaca acgcattctt ttatatggaa aacaaaaaaa gggaatgtgt 439321 acattggatt aacaaatttg ttaaatgaca atttgatcgt ggcgaaacag ctcagagaag 439381 ctttcggaga gaaggcgggg acgacgttat tgtatttgcg tctcgaggat atcagcccga 439441 tgtctgatga aaaactgctg cttcaagccg gtacatacct gcataagcgg catattcctt 439501 ttatcctggc ggtcattccg gtttacttga atccggaaac aggcgacaaa gtgtatttgt 439561 ctaatcaacc gaagatggtc aaggtgctga agaagctgca aagcatgggc ggcagtatca 439621 tagttcacgg ctatactcac gcttatcgct acagtgaaac aggagaggga tttgaatttt 439681 gggatgcaaa ggcggatcag ccgattacat ccggaaatgc cgaagacccc ccgtccattt 439741 tggagaaaga acaggacttc ccgaacgaac aagcctatca cagctatctt gaaccatttc 439801 gggaaaagga agaaacgtat acaaaacaaa aactgacgcg tgccattgag gatttgacat 439861 catcgggtct ttacccgctg gcgtttgaag cgccgcatta cacgatgtcc gaatatggct 439921 atcaaatcgc ctcgcagtat tttacaagca ttttcggcca ggtccagctc agcagcacaa 439981 catggaaaac atccggtgca cctccgtttg tgactgctcc ttcgatgctg cacggaatga 440041 cgctttatcc ggaaacgatc ggctttgtcg acacatcgaa gcaaaacccg ctcggtgaga 440101 tggaggagca tatctcccag atgattgatt ttgaaggcgg agtagccgga ggattttatc 440161 acccgtacct tgggatgaaa tatctgcctg agctggttga tcagatggaa cgcattccag 440221 acagtgaatg gcttgattta aagaaaacga aacaaaccgt caaaacagac aaagtggaaa 440281 ttcatacaag cggtgacgga acgattcagg tgaaaaacgg cgtaagcccc atttacgagt 440341 ttttcgatca tcaccggcaa acccctctgg aaaaggcgtt atggattctc tccgctgttg 440401 tgctcttatt tgtcatcatg tttgtcagtt atacgtttta cttgagagcc acattgaaaa 440461 aacgaatttt taaggagaga agaagccttg ggtaatacgc tgttctttat ctcgctaagt 440521 ttaatatggg ttatgcttct ctaccacatg ttcctcatgc agggcgggtt tcgccactat 440581 atgaccttcg aacggaatat cccgaagtgg agagaaaata tgaaggaact gccgaaggtc 440641 agcgtcctca tcccggcgca taacgaagag gttgtgattc ggcagacgct gaaggccatg 440701 gtcaaccttt attatccgaa ggaccggctg gagattatcg tcgttaatga taattcatca 440761 gaccggacgg gtgatatcgt caatgaattt tccgagaaat acgatttcat caaaatggtg 440821 attacgaagc cgccaaatgc aggaaaagga aaatcctctg cacttaactc gggttttgcc 440881 gaatcgaacg gcgatgtgat ctgtgtgtat gacgccgaca acacgcctga gaaaatggcc 440941 gtgtattacc tcgtgctcgg cctgatgaat gacgaaaagg caggcgccgt ggtagggaaa 441001 ttccgcgtca tcaatgcggc aaagacgctg ctgacgaggt ttattaatat cgaaacgatc 441061 tgttttcagt ggatggccca gggaggcaga tggaagtggt tcaaaatcgc cacgatccca 441121 ggcaccaact tcgcgatccg cagaagcatt atcgaaaagc tcggaggctg ggatgacaaa 441181 gcgctcgctg aggatactga gctgaccatc cgggtatata atctcggcta tcacatccgc 441241 tttttccctg ccgccatcac gtgggagcag gaaccggaaa catggaaggt atggtggcgc 441301 cagcgcaccc gatgggcgcg cggcaatcaa tatgtcgtgc tcaaattttt ggcgcagttt 441361 tttaagctga aacgaaaacg gattatcttt gatttgtttt attttttctt tacgtacttc 441421 ctgtttttct ttggcgtgat catgtcaaat gcgatttttg tagtgaattt gttttatgat 441481 ttgcatttgt ctgttggatt tttggcaatg attctctgga ttttggcgtt tttcttattt 441541 atgacagagg tcatgattac gttgagcatt gaaaaaacag aaatgaacaa gcaaaacttt 441601 tttatcgtat ttctcatgta cttcacatac tcgcaggcat ggattgtgct tgttatctac 441661 tctttattcg tagaaatcaa gcaccgttta ttcaagcaag aggtcaaatg gtacaagaca 441721 gaacgataca atcaacataa aagcgggtga cctttttgaa acaaataatg atttttctca 441781 caagcttcat gctgctggcg atgactggac aaacggctct tgccaaagac gtacaggtca 441841 gcggttcgct ccttgggaaa agcagccaag aacaagccaa acagcaggtg ctgacaagcg 441901 agctgattac actgtatgga tcaaaagaca gcgcagagct gacgtatcag atcccggcag 441961 gcgcctcttc gggcaatcag caattggtaa tcgaatacga ggcatcaaat cttttaattt 442021 ctccatcatc gttaacggtt gtcattgatg atgaaccggt caagacgtta aagcttgatg 442081 gtgattccaa acggaaaaca gtgaagctga atctgaataa aagccagtct gcgcaaggct 442141 atcacaacgt atcgctgaaa ttctacggcg taatgaaaga gggcgtgtgc gtcagacagg 442201 atacatcagg caactggatc aaaatttatc cggacagccg gctgacactt gctgacagca 442261 gtgaagcgaa gggaacgtcg ctggaccatt atccgtatcc tttcgcccaa tctggaaata 442321 cagcggaaga aacagctatc gtcattccgg ataacccaag ttcagcagaa atagaagctg 442381 ctgttaaaac agaaggctat ttgaaaacgg tggacagcag tgtcagtatt gcgtatgtca 442441 cggaatctga actgaaaaaa atcgataagc cgacgattgt tatcggcgtg gacaagcatt 442501 ggaacggcaa agtgaaaaaa ctgttgaaac aagccgggct acaggcaaaa ggagaaaacc 442561 ttctgcttgc ggagcgggtg ctgaaagcag agggcaaaca gcagccggtt ctgtttgcgc 442621 aagcggcgtc cgaggacgcg ctcacaaaaa aaatcagcgt gatgacagat cagacatata 442681 caggccagct cagcggcgat acactttcaa tcagcaagct tcagcagact gaaaaaaaag 442741 aaagcgataa gctgaccctt gagaattttg gagcgggtga tatcacaatt ggagccgaca 442801 aaacatcttc agcacattat ttttatccgg cttcggctgt tttagatgaa aaccaatcgg 442861 cgaagctgtc gcttaaactg aaaaagtctg aaacgattca agcctcaacg gctgaaaacg 442921 agtcagcctc tcaggctgca gaactgaaag tgatgatcaa cggccagccg cactcggtcc 442981 ggcttgatga attaggaaaa gaagataaaa acggattcta tcatgtcaca gtgaaagtgg 443041 accctaagct gctgcaaaaa aaccgctaca ttgatattca gttcgtcacg accggtttaa 443101 aggaaaacaa cccttgtaac accactgatg aagaaaagtg ggtttttatc gataaaaaca 443161 gtacattatc atacgccatc aaaggcatgt ccccgtcagc ggattttcaa gagtggccgc 443221 tgccttacgc cggaaaccag gatcaaacaa cgttaatcgt gcttcctgac accgtaagcc 443281 aatcgaagct agaggagctt tctctcgtaa cagaatcctt tggcaacgaa gcacagcatt 443341 catatacggt aaagaaatca tctgacgtta cagcaaatga tgcgaaagga cgaaacctca 443401 ttttcatagg agggatcaat caattttctc ttctgaagga gaaatcatca gatctgcttg 443461 tgccgcagga aaagaacggc tcgtttgatg tatctagttt cgagatgctg aatgagacga 443521 caaaacaagt ggtatttacc caagcatcgg tttgggattc acgctataca atggctgtct 443581 ttgcaccgtc aaaaggagat ggcacggctg tcacaaaaga gatcatcagt tatctgaaca 443641 gcaacgatga gtcggcaacc gtccttaatg aaacaaacag ccagcaggtg tttacaaacc 443701 accagcagct caaatcggaa acaaacagtt ccgatgcaga acaaccaaca caggatcata 443761 gccagaaatg gatgtatatt ggtgtgctgg cactcattat ggtggttgcg gcagtgttca 443821 tttggattgc cgtaagacgc aaaaaaagaa agacagatac agaataaaac agaggcgatt 443881 ttagcctctg tttttttatt tttggtaagt aaattccatt tgtggaacct gtcattttat 443941 ttttttctct cagccaataa gcctctttac aacgtgcggg aacgggagta tgatctcttt 444001 tagaaaacaa atcgcttaat ctgaaatcag agcgggggac ccaatagaac ggctttttgc 444061 cgttggggtg aatccttttt aggtagggct aactctcata tgcccgaatc cgtcagctaa 444121 cctcgtaagc gttcgtgaga ggagatgaat gaaacctgtg ttcgatgtta tggcacaggg 444181 gcatccgttt gcctctgtgt tttttgttgt tcatttttga atgcaaatcg catacagaga 444241 catcatagca gaaaggacta tcatcaacat gtgagagcaa gacactgatg gatgttttat 444301 tgttttaatt gaaaaatgag aaattaaaag gggaagacat cgatgtatca ttcaatcaaa 444361 cgttttttga ttgggaaacc actaaaatcc caagcagctg gagagcaaaa actgacgaaa 444421 ttaaaagcct tggctatgct ttcctcagat gcgctgtcat ctgtcgcata tgggacagaa 444481 caaattctaa tcattttggc aacaatcagt gcagccgcat tttggtactc cattccgatt 444541 gcggttggcg ttctcatctt gctgctcgca ctgattcttt catacaggca aattatttac 444601 gcttatccgc agggcggcgg ggcgtatatc gtttctaaag aaaatctcgg tgaaaaaccg 444661 ggattgattg cgggcggttc attgcttgtt gattatattt taacagtagc ggtaagtatt 444721 tccgcaggca cggatgccat cacgtcagcc tttcctgcat tgcatgatta tcatgtgccg 444781 atcgctattt ttctcgtgtt agtgattatg attttgaacc tgcgcgggct ttcggaatca 444841 gcatccatac ttgcctaccc ggtttatctg tttgtggtgg cgcttttggt tctcattgca 444901 gtcgggttgt ttaaacttat gacaggacaa atagaccagc cagcccatca tacatcgctc 444961 ggcacacctg tagccggcat tacgctattt ttgctgctta aggctttttc ctccggatgc 445021 tcagcgttga ccggggttga ggccatttct aatgcgattc ctgcattcaa aaacccgcct 445081 gcgcgaaacg cggcaagaac gcttgcgatg atggggattt tgctggcgat tctgttttcc 445141 ggcatcacgg ttctcgcgta cgggtatggt acggcgccga aacctgatga aacagtggtt 445201 tcacaaattg cgtccgaaac ctttgggcgg aatgtgttct actatgtcat ccaaggtgtc 445261 acatcgctta ttttggttct tgcggcaaat acgggattct cagccttccc gcagcttgcc 445321 ttcaacctgg cgagagacca gtatatgccg cgaatgttta cagtcagggg cgaccgctta 445381 ggcttctcaa atgggattat ctttttaggc tttgcctcca ttgttctcat tatcttattc 445441 gggggacaga cggagcactt aatcccgtta tatgctgtgg gcgtatttat tccatttacg 445501 ctttcacaaa ccggcatgtg catgaaatgg atcaagcaaa aaccaaaagg ctggatcgga 445561 aaaatgctga tcaactcctg cggcgctctg atatcattta tggttctatc cattctgttt 445621 gtgacgaagt ttaatgtcgt atggcctgtg ttaatcttta tgcctatcgt cgttttgctg 445681 ttttttgcga ttaaaaatca ctatactgcg gttggtgaac agcttcgcat cgtagacaaa 445741 gagccggaag aaatcaaagg caccgttgtg attgtgcctg tggccggtgt caccaccgtc 445801 gtgcaaaaat cgattcacta tgcgaaatca ctgtccgatc aggtgatcgc cgttcacgtg 445861 tcatttgaca gagaacagga aaagaaattc gaaaaacgtt gggaagagct taataacgga 445921 gtgcgtctcg tgacgcttca ctcctcttac agaagccttg tccatccgtt tgataagttt 445981 ttggaaacag ttgaggcaaa agcgaagaag gagcagtttt ccgttatggt gctgtttccg 446041 caatttataa cgaaaaaacg ctggcacacc atccttcaca accaatcggc cttcctcctc 446101 agagtccggc tgttctggaa aaaggacata atggttgcca cactgccgta tcattttaaa 446161 aagtaaagct ctaggaccaa gggaatcacc ttggtccttt ttagcgggaa aaggaggtat 446221 gggggtgtat acacaaggtg cttttgtgat cgtattgaac gaaagtcagc aaattctgct 446281 ggtgaaacga aaagatgtcc ctctatggga tttgccgggc ggcagggttg atcccgggga 446341 atcggctgag gaagcggcag tgcgggagat attggaagaa acgggataca atgcagcgct 446401 ttctgcgaaa ataggtgttt accaaaggcc aaagtttcaa gatgaacagc atctgttttt 446461 cggaagcatt acaggcggac aagcaatggc tgacggcaca gagacagcgg gattaaagtg 446521 ggtttccccg gggcgtttgc cgctttttat ggtgccgaat cgaaaaaggc agatcaatga 446581 tttcaagaac ggcgctcaag atgtaaatgt caccgtcaag gatagcgggt tgctcgcggc 446641 gatcgacctg ttgaaaagaa gactgggcaa gtgattcagg tctccgggtt ttaaagcctt 446701 tctcctgtgg tattgaaaaa aggaaaaagg aggatacgtt atggcacaca aaactgcagg 446761 acaagcaatg acagagctgc ttgagcaatg gggagttgat catgtatacg gcatccccgg 446821 agacagtata aatgagttta tcgaagaatt aagacacgaa agaaatcaac tgaagttcat 446881 tcaaacccgc cacgaagagg tagcggcact ggcagccgcg gctgaagcaa aactcaccgg 446941 caagatcgga gtctgtctgt caatcgcagg gccgggagcg gtgcacttat taaatggttt 447001 atatgatgct aaagccgacg gcgcccctgt gctggcgatt gcaggacagg tttcttctgg 447061 cgaagtcgga cgggactatt tccaggagat taagctggag caaatgtttg aggacgtggc 447121 cgtgttcaac agagaggtac atagcgcgga atcacttccg gatctcttaa atcaggcgat 447181 caggaccgcc tacagcaaaa aaggcgttgc ggtattgagc gtgtcagatg atttgtttgc 447241 ggagaaaatc aaacgggagc ccgtgtatac ttcaccggtg tatattgaag ggaacctaga 447301 accgaaaaaa gaacagctcg tcacctgcgc ccaatatatt aataacgcta agaaaccgat 447361 tatcctggca gggcagggaa tgaaaaaggc gaaacgggag ctcttagaat ttgcggacaa 447421 agccgccgct ccgatcgttg ttacactccc ggcaaagggt gttgttcccg ataagcaccc 447481 acattttctc ggcaacctcg gtcagatcgg aacaaagccg gcttacgagg caatggagga 447541 atgtgattta ttaatcatgc tcggaacgtc attcccgtac cgtgattatt tgcctgatga 447601 cacgccggcg atacagctcg attcagaccc ggcaaaaatc ggaaaacggt atccggtgac 447661 agcgggcctt gtctgtgatt cggctctcgg tttgcgcgaa ttgacagagt atattgaacg 447721 caaggaagac agaagattcc tgaatgcctg cacagaacat atgcagcatt ggtggaacga 447781 aattgaaaaa gatgagacag aggcaacaac accgcttaaa cctcagcagg tcgtggcccg 447841 tcttcaggaa gcggcagccg atgatgcggt gctctctgta gatgtcggca ctgtgacagt 447901 ctggatggcg cgtcatttca aaatgaacgc gaatcaggat ttcatcgttt ccagctggct 447961 tgcgacaatg ggctgcggcc tgccgggagc gattgcagcg agcttgtccg aaccggaacg 448021 ccaggcgatc gccgtctgcg gtgacggggg attttccatg gtcatgcagg accttccgac 448081 cgccgttaaa tataagctcc cgatcacagt cgttatttta aacaacgaaa atctcggcat 448141 gattgagtac gagcagcagg tcaaaggcaa tatcgactat gtcacaaaac ttcaaaatgt 448201 cgactatgcc gcatttgcag aaagctgcgg agcaaagggc atcaaagtga ccaaagcgga 448261 agagcttgcg ccggcttttc atgaggcgct gcactctgac caaccggtcg tagtggatgt 448321 catgattgga aacgaaccgc cgcttcctgg caaaatcacc tacgggcagg cgaaaggctt 448381 tagcaagtac atgctgaaaa acttcttcga aaaccaaaaa tttgaaatgc cgtcactgaa 448441 gaaaagtttg aaacggttat tttaaaaaaa caggggccct aagagccctt gttttttttt 448501 ttttttttgg aaacaaatgt attttcagca tgtttgaatt cataaaatga tcggtatatg 448561 tattaggaac tgatttcgcc atactcgaaa cagacaaaag gacaaatgca tcttgtttca 448621 aaggaagatg catttgtcct tgcatgctta ttcttatcaa atcttacaga actcttctca 448681 taataggtta tttttctttt ttcttcagcc cgaagaagaa aggaaaagca gaaccgacca 448741 agaaggtgcc gaataaaaac atgccgccga taaacacgtg gaaatttgtg tgtccggccg 448801 taaacgccgt gattagggaa atgatactga gcacgatcat ggcaatgccg ggcgcgactc 448861 tcatttttcc cttggattta tgggcagcaa cagaacataa aatgccgata acaataggaa 448921 caatccacaa ataaaacaga ataaatactg acatcatcaa aactccgatt tttcttctat 448981 cataacaaat ttctgtcaaa aagggtatca atgagctttt gcggaaaaat aaaaaccggc 449041 tttagaagcc ggttttttta tcgaaacgta tctacaatta aaaacacatt caaagcaacg 449101 atcaatacag caatcagcca agacaccact gtgatccatt tggcgttgat cagagatccc 449161 atgatccgtt tattgcttgt aaacataata agcggaatga gggcaaaggc gatcccgaag 449221 gacagcacga cctggctcag tacgagagcg gtcgtcggat taacacctga cgcgatgatc 449281 aagatcggcg gaatgatcgt gataaaacgc cgtacataca gcggaatgcg gtagttgata 449341 aatccttgca taatcacgtc gcctgaaagt gtgccgacag acgaactgga tagaccggca 449401 acgagcagcc cgatcccgaa caaagccgca gacatagggc tgacaagatg tccgaattgc 449461 tgaaatgcga cgtcgagatc ctcaacaaac aggccgtttt tgaagaataa tgcggcagcc 449521 acaatcagca tacttgcatt aatagcccct gcaatcagca tcgctattaa aatatcaata 449581 aattcaaacc taaagatttt tttccgttct gcatcagttt tgccaaccac ccgccgctgt 449641 gtaagggcag agtgtaaata aatggcgtgc ggcataacag ttgcgccaag aatacccgct 449701 gcaagaagca cactgtcggt gccatgaaac gccgggacaa aaaggccctt catcactgac 449761 acggcatcag gctttgcgaa aaaggtctgc aacgcaaagg cgatcacgac cacaaacagc 449821 ataccggcaa tacctgcttc aagtgagcga taaccacggc gctgaagctc caatatcgcg 449881 aaagaaccga tcgccgcaat aatagacgct tcaagcatcg gaatgccgaa cagcaaatac 449941 agtcccagag ccgctccgat aaattccgcc agatcagttg cgataatgac caactcgccc 450001 tgaatccata atccgatcga gacaggcttc gggaattctt cacgggcaac ctcaggcaga 450061 tttttgcctg tcgcaatacc gagtttggcg gatagggatt gaattaaaag cgccatgata 450121 ttggaaaata agatcaccca taagagcata tatccgtatt tagaacccgc cgaaatattc 450181 gttgcgaagt tgccgggatc aatataggca atggctgcta taaatgcagg gccgagaaaa 450241 gggagcagcc ctctgaatcc tctgattttc ccgtcaagcg catcttggac ggctttggaa 450301 cggggagatt gtgctgtgat gtccttgttc atcatgtctc acctgaattc tgtttgtttt 450361 tgccgtacaa caaagagttt ccttaaggca aattatttta tctacatcat atgaccatcc 450421 cggtttcttg tcaaccgaaa atgttcaaaa tacacttctg aatttttccc tgttatgtaa 450481 catgatatgt agggattcgt gataaggtcc catataaaaa gacatcgttt catttcgaaa 450541 cgatgcctcc tgtatctaat gagtctaggc ttccttccgc agcccgcgga atataaggcc 450601 cagcaagaac acgaagatgg ctgccccgat gatggccggg aaaatagcaa agccggcgag 450661 gctcggtccc catgtgccaa gaagtccgtg cccaatccaa gcgccgatca gcccggcaat 450721 catagagccg aaaattcctc ccggcagccg gtttcctaca atggcgctcc caattaatcc 450781 gataacaatt gcaacaacta atgaaaccaa aaagctaagc atcatgatca cctctcataa 450841 atgatttacc aatcaataac cgctcctgat catttcgaaa cacttgaaag catattcctt 450901 tatgatcctg ttttaatctt tctctgcaca ctgccgtcag ctaaatgaac aatgacctca 450961 gtgcctttat gcgccgcgat ttcctttgcc cgttcaatcg cttctttctt tgtatccttg 451021 atttcagaca cacgtttggc gccctcggct ttgactgccc agcctttttt atgcttaata 451081 acatgctctg ctttattcat gagctcgggg ccgctgccgc tgcttggatc agcatcgcgt 451141 tctgtctcat catcatgcgt caggaaatca tcaatttcat ctgtagaggc gttttccgcc 451201 cattccttcg ctttgcttgt cgcaattgga atcgcgcgcc cttcctcata gccttcatca 451261 atcatcgcat tcgcaatgtc tatcgccttt tttctcaccg gcttctcaag attttttaat 451321 gaagcaggat aatccttcat cgaccaaggc atgtctatca ctccttttcc ttttataaaa 451381 atggtacccg caggtgaaaa ataaaaacgc atccgaaaaa atgaaggtat actatatagt 451441 agaaaaaacg gaagggaagt gcgggttggg tgccaacaga acgaaaagaa gacttacatc 451501 agcaattaaa agagatagag aaatgggaaa aagatcagca aaaagtctgg ttttgggaaa 451561 agctcagccg tctcccgttt caactcctgg acaagctgac accagaattc atccagaaaa 451621 agatcggcaa gctcttggat gaggtcggca gctttgttca aacaggcgga cagtacctga 451681 catctgaaaa acagattatc aggatgtttc aaaagaaact gccggaggag atctttgaat 451741 cgctggagga catccggaaa gcgcctcttc ctgtcatgga tgaaattgcg gaaggaatgg 451801 gcaaaaacag aaccaacgca gcaaccgttc aaggcgcgac aaccggtgtg ggcggcgtgt 451861 ttacgctggc ggcagacatt ccggcagtgc ttggcttatc actaaaaaca ttacaggata 451921 tcgcagtcgc atacggctat gacccaaagg agaaaaaaga acgagtcttc attgtgaaat 451981 gcctgcagct tacgtcggct gatgttgtcg gcaaaagatc gattttgcag gaattaaaac 452041 actacgatca agaccgtaca tataagaatg tcgcttctca aatccaaggc tggcgagaag 452101 tcgttttggg ctatcgagac acgtttggct ggaaaaaact tttccagata gtgccggttg 452161 ccggaatggt ttttggcgcc gctgccaatc gctcaacatt aaacgacatt accgagacag 452221 gcatgatgct gtacaaaaag aggcgcattc ttgaacgact gaaagaaaca gaacgagaga 452281 tggaatagca gaaagcagac ggacaccgcg atccgcctgc tttttttagt ggaaacatac 452341 ccaatgtgtt ttgtttgttt aaaagaattg tgagcgggaa tacaacaacc aacaccaatt 452401 aaaggaggaa ttcaaaatgg cagacaataa caaaatgagc agagaagaag caggtagaaa 452461 aggcggagaa acaacaagca agaaccatga caaagaattc tatcaagaga ttggtcaaaa 452521 aggcggagaa gccactagca aaaaccatga caaagaattc tatcaggaaa tcggcgaaaa 452581 aggcggagaa gccactagca agaaccatga caaagagttc tatcaagaaa tcggtgaaaa 452641 aggcggagaa gccactagcg aaaatcatga caaagaattc tatcaagaaa tcggccgaaa 452701 aggcggagag gcaacaagca aaaatcatga taaagaattc taccaagaaa ttggctcaaa 452761 aggcggaaac gcccgcaaca acgactaatc aaaagcataa aggcagacaa cctgtaaata 452821 aaaaagcgat ccggcacatc agctggatcg cttttttttg gaatcttctc aatttatgcc 452881 gctattgaga tacaataagt gaaaaagggg ttttcgctaa tgtccaagat gcaaaacttg 452941 ctcgccatcg caaatgaagt caaagaaaag cacgccaatt tttcaatctc agaggtcaac 453001 gaccactgcg tgcgccttgc ggtgtttacg ggagaatatg actggcacca tcaccctgac 453061 tcagacgaat tgtttattgt tcttgaaggg gagctgctga tcgattttaa ggacaaagaa 453121 accgcggtgc tcaaagcaaa tgacagcctg ctgatcccta aaggcacggt tcaccgcaca 453181 cgctcttacg tcagaacggt aaatctctgt gtggagcata aacaagccga aaccgtcatc 453241 atagaggagc agccatgcta atcaaaaaga tgatatgtga agtagatgct gcaaacgctg 453301 aagcatttgc aaaagcgcag tcacagtggg aagcgttatc gcatataagc ggctttatca 453361 aacaggccgg cggctggcga aaaacgatag acgagccgct caccgcagaa atcatcagtg 453421 tatgggaaaa cagagaagcc tatgatcatt ttatggagaa cgaacatgac agcatatacg 453481 aggaaaacga tcagaaggct gtaattcttt cgatagaggt gacggtgtac gaagaggata 453541 aaccgttcgt tcacgatctg ttacataacc ccgatatccg gtacgaacca aactggacgg 453601 ttctgaaggc ataatcaaag cccaaaacat catgttttgg gcttgtctct ttactcgcgt 453661 cccggaagtg tattatgaac aaaaggcggt gctggtttta actccggttt ttctccaaac 453721 gtttttgctt ctttcacata ttcaaaggct tctccgtccg gcgctttttc attcagccag 453781 ttttgctcgg cgcttacttc gccttcagag aaattgataa gctgatgtga gaactcttgt 453841 ttttcgagcg ctttcgggaa tgtacccggc acaaccggac cttcctgtgc ttctaattct 453901 ttaatggcgg cgagccattg gttctggtgc atcgtgtcac gcgccagcag gaagctgagc 453961 atatctttga cgcctttgtc atccgtcatt tcaaacaggc gtgcgacctg cagacggccc 454021 tgagattccg cattcaggtt ggcgcggaag tctgccagca ggtttccgct tgctacgata 454081 taaccgccgc tccaaggtac gcctgtactg ctttccggca tggcgccaag tcctgataca 454141 atcgcatggt gagggttcat gccgcctagg atggagccga tgaccggatc ttcagcagct 454201 ttttcctgct gatcaagagg ggcatcctca agaagtctgg caatcatcgt tgcgatcatt 454261 tcaacatgcc cgagctcctc agttgccgta tccatcagca agtccttgta tttttcattt 454321 cctcttgtgt tccagccttg aaataagtac tgcatggcaa ctgaaatttc tccgaattgc 454381 ccgcctaaaa tttcttgcat ttttttagcg aataatggat ctggacgatc tggtttagca 454441 ggatgctgca gcatttttgt gtgcttaaac atgtacccat ctcctttttc gtttatctct 454501 ttttatattt ccgatcgata gaaagataaa cgaaaaacag cgtatcgaga tgggaactat 454561 gaatcttttc gcagctccaa cagttcccgg atcagctccc ggccaaagat gggctcatac 454621 tgccggtaaa cagggtcaag acgcttcatc cattcttgtt tctctttatc tgacagctca 454681 taaatatgta tagcagaatt ctttttgatt tcttccagct gctccttgtt catttgttcg 454741 gcatacgttt cattccactc cgttgtctcc ttcatcgctt cagtcaaaat gcgtcttgtt 454801 tctggtgttt gcgccttcca gaagtgttca tcagtcatga cagcgtagcc gagataaccg 454861 tggctgctta ttgtcaaata gtcctgaaca ttataaaatt ttttagaata gatgtttgaa 454921 attgtatttt cttcgccatc gactacattg ttttctaaca gctgaaaggt agaattgaag 454981 gattcctgat gaggtgttgc gccaagcagc ttgaactgat cctcaatcac atcgctttgc 455041 ataatgcgca gatcctgccc ttttaagtca tccggtgttt tgaccggccc ttgatttgtt 455101 gtgatttgct taaagccgtt cgtccaatag gccaatcctt tcaattggtt tttctttaga 455161 gaatcaaaca gctgtgtgcc gatgcttccg ttcagccctt ttttgacggc gttgtaatct 455221 gtaaatgcat acggcagatc cagcactccc cattcaggcg agagcatgcc gagcttcgat 455281 gtggaggggg cgataaattg aacatcgccg ttttgcaatg cttcaatttc ttcaatgtcc 455341 gagtacaggc ttccattcgg aaatacttct atttttattt ttccgcctga tttttcgttc 455401 accagatcag cgaatttatt ggcggccagc ccttttggcg tattttcagc aaccacgtgg 455461 ctgaatttaa acacgatttg atcctgcagg ccttcctggt cgtcatcata aacaatcttt 455521 ttattgccgg tatgatcatg gaatccgata aataaagcgg ttgcaattcc agcgatcatc 455581 agtgcgagac atgcaagcaa actcttcatg aaaagccctc ccctatgtta aggataatgg 455641 gggctatgac attcgtaaag acctgaaagg agaagctgat gaacaaaaag aagctctcaa 455701 tccgttggaa aatcacgatc ttatcctata tactcgtcat tttctccttt ttgatcggcg 455761 gcattgtgct catcggcaac attcagcata cagaggagcg ggagctgaaa aagcggctga 455821 tgaatacggc ccggacggtg tcagagatga cagaagtgaa agaagccttg gcgcgaaaaa 455881 aacaaacaga agcggttcgc catgcggttg aagaaatcag gatgattaat gaagcagact 455941 atattgtcgt catggatatg aatcacatcc gatatacgca tcctgtcagc acaagcattg 456001 gcaagaaatc agaaggtgca gacgaggagg cagcttttgc ggagcacatt tatttctctg 456061 aagcaaaggg cgagatcggc acggcggttc gcgcttttta tccggtaaag gatcaagacc 456121 tgaaccaaat aggcgtggtg cttgtcggaa aaacgctgcc ggggatcgct gacatcctgc 456181 ttcatttaaa gcgtgatatc gccttcatcg ttgtgctgac actcggcttt ggccttgctg 456241 gttccttttt gctggcccgc catatcaaaa aacaaatgtt tcagcttgaa ccccatgaga 456301 ttgtccgaat gtatgaagaa cggacagcga cgtttcactc gatgaatgaa ggggtgatcg 456361 ctattgacaa tcgtctcgtc attacgatct tcaatgaaaa agcgaaacag atctttgaag 456421 tgcaggggga tctaatcggc aaggtgattt gggaggttct caaggattcg cgcctgcccg 456481 aaatcgtgga gcggaacaaa gcggtttata atgaagaaat tcgtgtcagc ggtaaggtga 456541 tcatgagcag cagaattccg atcgtcatga agaaaaaagt gatcggcgcc gttgcgattt 456601 ttcaggacag aacggaagcg gccaagatgg cagaggaatt gactggtgtc agaaactttg 456661 tggaggcgct ccgtgtccaa aaccatgagc atatgaataa gctgcacacg atcgccggtc 456721 tcatccagct ggggaaatct gaaaaagcct tgcagcttgc attccaggcg tcaactgagc 456781 aggaaaatgt gactgaattt ctgcaccgct cgattcaaaa tgacgctgcg gcaggccttc 456841 tattaagtaa aatcagaagg ggaagagagc tcggcattgc tgttcatata gatgaaaaca 456901 gcagtcttca gcaatttccc gagcatgttg atcagcatga tattgtcgtg cttttgggga 456961 atctgattga aaatgccttc ggctcatttg aaaccgttca atctgaagac aaacgaattg 457021 acattagtat cgaacaaaca gatgatatcc ttgctatttt aatagaagat aacggctgcg 457081 gaattgaacc gacacatatg cctcgccttt atgacaaagg ttttacggtc aataaaactg 457141 gcggcacagg ctatggcctg tatctagtga aacaaatcat agacaaagga tcgggcacga 457201 tagaagttga ttcacatgcg gggcagggga catctttttc tatcgttttt ccaatgaagg 457261 gggaggaagc acagcatggc tcgtaaagaa tggaaggttc tgctcattga agacgatccg 457321 atggttcaag aggtcaataa ggatttcatt acaactgtta aaggcgttac tgtctgtgca 457381 acggcaggaa acggagagga aggcatgaag ctgattaaag aagaacagcc agatctcgtc 457441 attctcgatg tgtacatgcc gaaaaaagac ggcatcaaga ccttgcagga gatcagaaag 457501 caaaagcttg aagtggatgt cattgtcgtc tccgctgcaa aagacaagga aacgatctca 457561 ctcatgctgc aaaacggggc ggttgactat atcttaaagc cgtttaagct tgagcgaatg 457621 agacaggcac tcgaaaagta caagcaatat aaacaaaaaa tcgaagcgaa tgatacgctg 457681 tcccaggaac agctcgatgc gatcctgaat attccgcagc aggccgtaca ggatctgccg 457741 aaagggttga atcacttcac gatgaatgaa gtcactgctt ttttgaaaca gcaaaccgca 457801 tccctttctg ctgaagaggt tgccaaggcg ctcggcatcg ccagagtgac agccagacga 457861 tatcttgatt acttagaaaa aaccgggatc atcaaattgg acgttcaata cggcggagtc 457921 ggccggccgg tcaaccgcta cgtgttaaaa ggataaacct gagaccaaaa agaccaaaat 457981 gtccgttatg atcataaact tccccagact gtatgaaaac gctatcattc tagtaagaaa 458041 gacacaaaag gcgaatagga cagggggatg aaggatatga aactgtttaa aaatttaaca 458101 gttcaggtca taaccgcggt catcatcggg gtcattgtcg ggctggtctg gccggatgtc 458161 ggcaaagaaa tgaaaccgct tggtgataca tttatcaacg ctgttaaaat ggtgatcgca 458221 ccaatcattt tcttcacaat cgttctcggg attgcaaaaa tgggcgatat gaagaaggtt 458281 ggaaaagtag ggggaaaagc gtttatctat ttcgaggttg tcaccaccct cgcactcatt 458341 atcggtttat ttgtcgtcaa tattatgaag ccgggtgcgg gtcttgatta cagcaagctt 458401 gaaaaaggag atgtatcaca atacacgcaa aatggcggtc agggaatcga ctggattgaa 458461 tttattacac acattgttcc gtccaacatg gttgatgcct tcgcaaaagg ggacattttg 458521 caggtcttat tcttttctat tcttttcgga gtgggtcttg cggcattagg cgaaaaagga 458581 aaaagcgtca ttgatttctt cgacaaggtt tctcacgttt ttttcaaaat tatcggctac 458641 attatgcgtg ccgcgccaat cggggcattc ggggcgatgg cgtatacaat cggacacttc 458701 gggctcgatt ccatcaaacc gctggcaagc ttaatgatgt ctgtttatat tacgatgttc 458761 ctgttcgtat ttgttgcttt aaatatcatc tgcaagcttt acggattcag cctgtggaat 458821 taccttcgct tcattaagga tgagcttttg atcgtgcttg gcacaagctc ttccgaatcg 458881 gtgcttccgc gtatgatgga taaaatggag cgctacggct gttccaaatc cgttgtcggg 458941 cttgttattc cgacgggcta ttcgtttaac ctcgacggca catccatcta tttatcaatg 459001 gcgactgtct ttttggcaca ggtgtttgga gtagacctca gcatcggcca gcaaattacg 459061 attatcctcg ttctgatgct gacatcgaag ggagcggcag gtgtgacggg aagcggattt 459121 atcgtccttg cctcaacgct gtcagcgctg caggtcattc cgctggaggg gcttgcactc 459181 ctgctcgggg tcgaccgttt catgagtgaa ggaagagcca ttgtgaacct gatcggaaac 459241 ggaatcgcca cgatcattgt tgccaaaagc gaaaatgaat ttgatgaagc aaaaagcata 459301 gaggctgttg aaggcatgaa aaaaatgaaa acagcagtct gaaaaaagaa cggcccatcc 459361 atgggccgtt tttttaattg tttaagaatt attaaggtaa ggacagagac ctcagcattt 459421 ttttgttata taatttacaa atggatacta tattgaatga aggacgtttg tcctaacagg 459481 agtgtataaa tggccgcttt agttaaattt tttcagcacc cgggagtaag gcgtttctcc 459541 atctttgtcg tgttaactgg tgtgttatat ctatttaaga gcatgatcaa cttaatattg 459601 cttaccttca ttttcacatt tctaatggat cgtttggagc ttgtcgtgcg gcagtttgta 459661 agccagttct tccgcgtgag ccagcgggtt gtcattacgt ttctttacat gttgctggct 459721 gtgctgctta cagtcggggg ctttgtgttt tatccggtcg tcgcggcgca gatccagcag 459781 ctggtaaagc agattaaaca tattgcgtat catcctgaca gcatcccttt ctttgatgag 459841 atcaccagtg tcttcggaga tattaacatc agttcatatg tcaaagaggg cttcaatgta 459901 gtgtatacgt atctggccga tatcagcaca ttcggcttgc aggtcgtgat ggcgctcatt 459961 cttagcatgt ttttcttatt tgagaaaaaa cggctttctg aattcatggc gaaatttaaa 460021 acgagcaaac ttagggtctt ttatgaggag attgcttttt tcggaagcaa atttgcaaga 460081 acgttcggca aggtgctcga ggctcaattt atcattgcgc tcgtcaactg tattctgacg 460141 tttatcgcgc tttggattat gcattttccg cagctgtttg ggctttcgat tatggtgttc 460201 ttccttggat tgatccctgt agcaggcgtc gtcatttccc tgattccgct cagcattatc 460261 gcctacagca ctggcggtgg aatgtatgtg ctctacattg tccttgtcat attcgccatt 460321 catgcgatcg aaacctattt cttaaatccg aagctgatgt cggcgaaaac agagctgcca 460381 atctttttca ccttcacagt actcattttc tctgaacact tcttcggcat ttggggttta 460441 attatcggga ttccgatctt tgtgtttctc cttgatattc tggatgtcac caacaaggaa 460501 gataggtcta aaggaccccg agagaatagc gataaaaagt agtttaaaat cgaataatga 460561 gtgtgcctcg atctgccggc ctgcctgttc agggcatgga attaagactc ggaatcggag 460621 cttggcattg ccttgcacag tggtgaacac aacaggtgac aatgcttgtc atcagtacgg 460681 aaactgaaaa gaacaaacag tcggagcaaa cgctcatcat cggtttaacc aaacatttgg 460741 aagcaacaaa tgctataata caaacagtgc ctaatgttgg gcactgttta ttttttgtcg 460801 aaaaaggagg aaggctttat ggctgagccg attttacata ttgaaggcct cgataaaaaa 460861 attgggtcta aacagatttt aaaacagatc agcatggacg tcatggaggg tgaaatcatc 460921 ggccttctcg gtccgaatgg ttccggaaaa acaacactca tccgtatcat cgtcgggctg 460981 ttgaaacaaa acagcggaag cgtgacaatc agcggattcc agcatgatac agagtttgaa 461041 aaagcgatgg aagcggttgg agcgattgtt gagaaccctg agttctatcc gtacctgaca 461101 ggctgggaaa acctcaagca ctttgcgaat atgcacaaaa aaatagcgga tgaacggctt 461161 gatgaagtgg tggaacgtgt cgggctgacg tcagcgattc atgataaggt gaaaacctat 461221 tcccttggga tgcgccagcg tctgggaatc gcccaggcaa ttcttcaccg gccgaagctt 461281 ctcattctag atgaaccgac aaacggcctc gatcctgcgg ggatgaagga ttttcgggat 461341 catattaagg aactcgcaga aatggaagga acagctgtcc tgttcgccac tcatttattg 461401 cgcgaggttg aagacttgtg cgaccgtgtc atcatcattc aaaaaggtga gatcaaagcg 461461 gaagtcagct tacaaggaac cgatcaaacc acagaaaaag cgattataga agtgcagccg 461521 caagaaaaag cgctcaattg gctgacaggc aatcaatatc aagctgagag ccaagacggg 461581 acgattgtag ttgaggtggc aaaagaaaac ataccggagc tgaaccgatc acttgtcgga 461641 caagatctga atgtattttc cattacgcct tacacgcagt cactggaaga cgaatttata 461701 aaagcgacaa cagctcatca agaggaggga gaagagcttg tctaaattaa tttggaatga 461761 acatatgaaa ctttttaatc ggaaggtcac tttggtttct cttatcctga tggctgtctt 461821 tcaattcttc atggcattga tcattaaacg gattgtcatc agtgccggaa cagatgaaaa 461881 cttcatcggc tatttatcgt atacaccgag cctgaacatt ttgctgcagg ctttaacgat 461941 cgtaattgca gcaacaattg tttcgatgga atttgataaa aagacgatca aatttttgct 462001 cattcgtccg gttaaacgcc aaaaggtctt ttggtcaaaa ttaatcacag tcgtgatggt 462061 cagcttctat ttgtatttgg catactacat tctggcatta ttattcggtc tcttgttttt 462121 tggcacatcg gtgactgcgg aatcaaagac attgctggtc aacaccttgg cgctgatcgg 462181 gtcaaactgg cttgaagctg taatgatggg attattcggg ctgctttgtt cttcgctgtt 462241 ccgcaatagc gcggtagcag ttgttgtttc ttttgtcgtt ttatacggag cgagtacact 462301 tgttcagctc atgaagttgt ttgaaaacaa gtggggcagc tttttgcttt ttgcgaacac 462361 tgactttacg caatacagaa gcggagagac agcgttgttt tcaggcatga cgccattgtt 462421 ttcaattgga attctcatca tacatgccat attcttcatc gttgttggct ggtggtgctt 462481 ctgtaaacgg gatgttcggg tctaaaggca aggaatgaca tttttgtgaa aaagctcacg 462541 taaatcaata tcatttgata ttttggttta tactaaaggt actgacggag gtgtctcgat 462601 tgaggaactt tattaccgct ttaccgatcg tattgctgct tggattctca tttgtgtcat 462661 tcatgtttca gtttgaacat cttgtttatt tcaggctcgc gcttgggttg ttttctctcg 462721 tgggactgta catgatatat aaaatgaaga cgggcatccg ctattttatc atctatctgt 462781 atgccagctg gattgtgttg gccgcagtga ccgcttttga agagccgatt ttctcaagct 462841 ttttctttgg cggcctggtg atgacgatgg gttacctgac atatatgctg atttatctcg 462901 gcatgaaaca agaccgggat gcaaatcctg tgtaatcgcg ctgttccctt ggggaacggc 462961 gtgtttttct atactgggca aaaggttaac agttgcggaa aaatggcagg aaatctataa 463021 tacatattaa atttatcgga attaaaactg gggggctgcc ggatgtcatt atttatacaa 463081 aacgatcaac agcggcaatg gatggagaaa atcggacgga ttgcggatga atttcagcaa 463141 acagctgctg aagatgacga acagggacgt tttcctgcag agaaaataca aaaactgcgt 463201 gatgctgggt atacagcatt aacattgccg gcatctcatg gcggaggggg catttctgtt 463261 tacgatatgc tcttgtttca agaacggctt gcacggggag atgctccgac ggctcttagc 463321 atcggctggc atttgagcgt gatcggggag cttggagaag gcaacagctg ggatgaagac 463381 gtatttgcat ttgttgccaa ggaagtccaa aacggagccg tcattaacag ggcggcgact 463441 gaagcgaaaa ccggaagccc gacaagagga gggcgtcccg gtacacacgc cgtcaaaaag 463501 gatggcaaat gggcagtgaa cgggagaaaa acctttacga cgatgtcaca agctctggat 463561 tattttttag taaccgcatg gattgaggac aaacaaacaa caggcgtgtt tctcattcat 463621 aaagatgatc ccggcttgtc gattgaagaa acgtgggata tgatggcgat gcgggcgact 463681 gggagccatg accttgtact gaacgaagta atgcttgatg agaataagct ggtggaactg 463741 cttcaagggc ctcgtggagc taagccgaat ggctggctgc ttcacattcc tgcgatttat 463801 cttggtgtgg ctcaagctgc tcgtgactat gcagtgcaat ttgcatctga gtattctcca 463861 aacagcttga atggaccgat caagaatgtc ccggccgtac agcaaagaac aggcgaaatg 463921 gagcttgaac tgctcaatgc cagacacttt cttttccata tcgctcaatt gtatgacgat 463981 ccggtgcggc gtccacactt gaccagcgag ctcggtgcgg cgaaacatat cgtcacaaac 464041 gctgcgctgt ctgttgttga taaagcgatg agaattgtcg gggccaaaag cctggaacga 464101 accaacccgc ttcagcgcta ttaccgtgat gtgcgcgccg gtcttcacaa cccgccgatg 464161 gatgacgccg tgatacacaa gctggcagct gaagcgtttg agtcataaaa aaaagagcct 464221 taccggctct ttttatgtat tgttttgctc ttgcagattt ttttgatgct tgcggtcgat 464281 cctgtcataa ataacgttca tcagctttgg attgcccata atcgcctctt tgttttcctg 464341 gatcagctgt tggtaagttt tcactttacg cttcggcatg ctccggcgcc ctcctgacat 464401 gtttgtattc actttctaac tccgtcagcg acaattcata cagatgacgc tttgactttt 464461 tgtatatacc attctgtatt aacagatgaa tgagctgttt ttttctgatt tctgcagact 464521 gaggtgtcat tgtgtcacca acctccaatc aaacgatatt gataatcatt atcaattaac 464581 ttcagtatac aatgtccgca atagcctgta aagatgaaaa gagtcctatt cttggccaat 464641 ttacaaacat tcaacaaatc gacaaaaagt ttcccgggca ataatttgct gtcgaaatat 464701 tccgcttcat tgaacgcacc ctgctatttt tcatgttttg aaccatacta tgtaatagaa 464761 tggaggctgg tattcaatgg agcggacaga aaatctgaaa aagggagaaa aaggggcgct 464821 cctcaatatt tttgcatatg tcatccttgc tgttgtaaag ctagttatcg ggattctata 464881 tcattctgaa gcgctgagag cagacgggtt aaataatgga acagatattg ttgcgtcagt 464941 agcagtgctg ataggattgc ggatttctca aagaccggct gacagcgatc atccatacgg 465001 ccattatcgg gctgaaacaa tttcgtctct tgttgcgtct tttattatga tggcagtcgg 465061 cattgaagtg ttaatcggcg gaggaaaagc gattgcgggc ggcacaacgg aaacgccaaa 465121 tcttatcgcg gcatggacgg cgttaggcag tgctgtgttt atgtatggca tctatttata 465181 taacaaaagg ctggcagcgt ccattaaaag ctctgccctg atggcagcgg caaaggacag 465241 caggtcagac gcttttgtaa gtgccggcgc gtttatcggt gttttttcgt cccagctgaa 465301 gctgccgtgg gttgatccgg taacggcttt tatcatcggc atcatcattt gcaaaactgc 465361 gtgggatatc tttaaagacg cttcacattc cttaacagac ggcttccatt taaaagatct 465421 tgagccttac aaacagaccg tcggcaggat cgaaaatgtg catcgcctaa aggatgtgaa 465481 agcgaggtat ttaggcagta cagttcatat cgagatggtg attacggttg atccgaagct 465541 tacagtagaa gaaggccatg gagtggcgga tgaagtagaa gacaaaataa aacatgaaca 465601 cgatgtcact catgttcatg ttcatgtaga gcctgacgac ataaaataag gctgtttaac 465661 gaattagctt atatgttcag ataaaaattc agtcacttct tcaggcgttt tggcattggc 465721 gctgtgaagg tgagctgttt tttcaccgtt cttgaaaata agcaggctgg gaatgcccat 465781 tacttggtat ttttcagcca ggtcaggaag ctcgtcctta ttcagctcat accagtcgtt 465841 ttggttgtat tcttccaaaa tatcgccgat gaacatattc atgcgtgtgc agtctgggca 465901 ccaatcagca taaaacttta caatgatttc tttatcagat tgaatcagtt cattaaattg 465961 ttcgtttgtt gtgatttttt tcatatgtca catctccttt tcaatgccat tttaatataa 466021 aataaaaagg aattacatac aaatgcattc aacatcagca tgcccaaaaa taattagatc 466081 attttccggt gaaaatgata agatagtaaa gatgaattgt agtgggggga gtatccattg 466141 aaaacaagtc taggattagt gtacggagga aagtcggcag aacataatgt ttccctgcag 466201 acagctctgg ctgtaatcaa agcgctaaat actgagaagt ttgatataca tccgatttat 466261 ataacagaaa aaggcgaatg ggttagaggc gcccgtttaa ctgaacctgt ttcaaacgtg 466321 aaaatgcttc aatttgagca aggaggcagt gctttttctc cagctgccct gaaccaggag 466381 atgtttccgc aggaagcgtc acagcaaaat gaagccatcg acgtcgtatt cccgctcctc 466441 cacggaccga acggagaaga cggtacgatc cagggaatgc tcgagctgtt gaacattcct 466501 tatgtcggca acggagtgct tgcttcctca gctggcatgg ataaagttgt catgaaacat 466561 ttatttgcgc aggttggcct tgctcaggct aaatacgcag ctttccttaa gaaagactgg 466621 actcgttctc cgaaagaaag ctgtgaggag gttgaacagg aattaggcta cccttgcttc 466681 gtaaaaccgg cgaacctcgg ctcaagtgtc ggaatcagca aatgccgaaa ccgtgaagaa 466741 ctgcaaaaag cgtttgagct tgctttccaa tatgaccgca aagtcgtcgt tgaagaagga 466801 attaacggcc gcgagatcga aatcggcgtt cttggaaatg atgatcctaa atgctctgtt 466861 gtgggagaaa tcgcaccgaa gacagatttc tacgattaca aagcgaaata tgaggatgga 466921 gatactgatc tgatgattcc ggcgattgtg actgatgagg aatacgcaac aatcagtgat 466981 atggcgatca aagcgtttaa agcgatcgac ggttcaggac tcgtcagagc ggactttttc 467041 ctgacagctg acggcgaagt tctgatcaat gaagtcaaca caatgcctgg ctttacacct 467101 ttcagcatgt tcccgttgct ctggaaagaa gccggagtgg aatatgctga cctgattgaa 467161 cagcttgtgg agcttgcaaa agaacgccac gctgaaaaac aattgattaa gcatacattc 467221 taatgaagaa ggacactgcc ggtaaaaggg cagtgttttt tcccgtatat acaaaagaaa 467281 gagagggacc ttacttgatt aagcgaacag taaaaaacat tgccgaaatg gttaaaggca 467341 cactagcaaa tccgcaatat gaacaaacag tcattcatgg agtggcaacc gatacaagaa 467401 aactggaaca acatcagctc tttattccgc tgaaagggga acgttttgac ggccactctt 467461 ttgtggagca ggcctttgaa gctggtgtag cggctgttct ttgggatcgg tcagtaccaa 467521 atccgcccga gaatcacgcc gtcattttag tggacgatac ccttactgca cttcagcagc 467581 ttgcaaaagc ttatttgcag gagcttggca cgcgtgtcat cggagtaacc ggaagcaatg 467641 gcaaaacgac aacaaaagat atgattcacg ccgtattggg gacccagtac cgtgtccaca 467701 aaactggagg aaacttcaat aatcatatcg gtttgccgct gacggtttta gcgatgcctg 467761 aaaatacgga gatcgccgta ttggagatgg gaatgagcgc caaaggagaa attgacctct 467821 tgagccgact ggcaaacccg gatgcggcag tgattacgaa tatcggcgaa tcgcatatgc 467881 aagacctcgg ctctagagag ggcatcgcgg aggcgaagct tgaaatcata aacgggctta 467941 aagaagacgg agtgctgatt tatatcgggg acgaaccgct tcttcaaaat gcatacagct 468001 gccagacgaa aacgtacggt acgggaacgc ataatgatta tcagcttcag gatgtcagcc 468061 agagtgagga aggaacccat tttacaatca aagggataga aaacacgttt tttattccaa 468121 tactcggcaa gcacaatgtg atgaacgcca tggctgcaat tgctgcaggg gcttattttg 468181 gcatcgcgcc tgaggatgcg gcaaaaggac tgagcggcct aaaggtaacc gggatgaggc 468241 ttgaactcat caaaacagac agcggccttt cgataatcaa tgacgcttat aatgcgagcc 468301 cgacttccat gaaagctgca attcaattga cagaaagcct tgaaggctac ggcaaaaaaa 468361 tgctcgtgct cggtgatatg cttgaactcg gcgatcttga agaaacgttc cataaagagt 468421 gcggcgctgt gatcagccct gataaaattg accgcgtctt tacgtacgga aaactgggag 468481 cttttatcgc ggaaggcgcc ctgaaacact ttgagaaaga ccgcgtcagc cattacactg 468541 agaaaaaaga tctccttcaa gctgtgaagg aaaacgcatc aaaaggcgat ttgattttat 468601 tcaaagcgtc cagaggtatg aagcttgaag aaatcgttaa agatttaata gagagcccgc 468661 tttcataaga aaatattttg cgaaaaaacg catattgcat cataaaataa cctgatatgc 468721 aaacactaat gtatgccggc cgaaaattat gtatatctgg ccggctgcgg ctatgataca 468781 atatatatag gttatttcgc gatacgaaca tattcgtccg gacttttcat cgtgacccga 468841 agttctccgc tggattcttg ggagcggatg gagcagcagc cggcatattc gagatgccga 468901 tctgcttctc atcttattga aaaacaaata gtgtaatggt aagataaaac ttaaagtaat 468961 tcgggctttg tatacggatg gatcctgtcc ttcttgtcta aagggcagtt ttataagtgg 469021 taaatcacga cattactgaa acagcaatta gaaggagttt gaataatttg actataacgt 469081 ttcaagattt taatttaagt tctgatctca tgaaagcaat taatcgtatg ggatttgaag 469141 aagcaacacc gattcaggca caaacgatac cgctcggact ttcaaataaa gacgtcattg 469201 gacaagcgca aacaggtaca ggtaaaacag ctgcgtttgg tatacccctt gttgaaaaaa 469261 ttaaccccga gtctcctaat attcaagcaa tcgtaatcgc gccaacccgt gaattagcca 469321 ttcaagtatc tgaagaattg tataaaatcg gacaagataa acgtgcgaag gttcttccta 469381 tttacggcgg acaggatatt ggacggcaaa tccgggcgtt aaagaagaat ccgaatatta 469441 ttgtcggaac acctggacgt cttcttgacc acatcaaccg ccgcaccatt cgtttaaaca 469501 atgtaaatac cgttgtaatg gatgaagcgg atgaaatgct gaacatggga ttcattgacg 469561 atattgaatc tatcctttca aacgtgccaa gcgagcatca gacacttctg ttctctgcca 469621 caatgcctgc gccgatcaaa cgcattgcag agcgcttcat gactgagccg gaacacgtaa 469681 aagtaaaagc gaaagaaatg acggtttcta acattcagca gttctatttg gaagtgcaag 469741 aacgtaaaaa attcgataca ctgactcgcc ttcttgatat tcagtctcct gagcttgcga 469801 tcgtattcgg acgtacaaaa cgccgtgtcg atgagctggc tgaagctctg aaccttcgcg 469861 gatatgcagc tgaaggtatt cacggtgact taacgcaggc gaaacgtatg gttgcgcttc 469921 gtaaatttaa agaaggcgca atcgaagttc tagtcgcaac tgatgttgcc gctcgcggac 469981 ttgatatctc aggtgttaca cacgtataca acttcgacgt gcctcaagat cctgaaagct 470041 acgttcaccg tatcggaaga acgggccgtg caggaaaaac aggtatggcg atgacgttca 470101 ttacaccgcg tgagaaaagc atgcttcgcg caattgaaca aacaacaaaa cgcaaaatgg 470161 accgcatgaa ggagcctaca cttgatgaag cgttagaagg tcagcaacag gttactgttg 470221 aacgtcttcg cacaacaatc agtgaaaaca acctgaactt ctacatgaca gcggcagctg 470281 agctgcttga agatcatgat gcagtaacag tggttgcggc ggctatcaaa atggctacaa 470341 aagagccaga cgacacaccg gttcgcttaa cagacgaagc gccgatggtc agcaaacgct 470401 acaagaacca gcgctcttct aaacgcagag acggtcaagg cggcggctac cgcggcggaa 470461 aagggaaaag caacaaccgt tcttcctatg acaaaaagcg ttcaaacgat cgccgttctt 470521 caggtgacag acgccagaaa aaatcttact aatttgatcg attcagagcc caaaacatga 470581 tgttttgggc ttttttatgt tcgtgatttg ttattcagca aactttcagc tgacggaagc 470641 catttttctc tgtatgctta agaatgaaac ctttctgtaa aagagacgta taaataacga 470701 cgaaaaaaag ggaggtaggt atttttgaga gagcagccaa aaaaccaaat cagtccagac 470761 ggattaaagg tttggcgact tcaagagatc atcatatccg ctgtttgctt gcttattgtc 470821 attgcagttg cagtgttaag ctattatttt cattggccgt actggatcag cggcgtgctc 470881 ggcgctgttt ggctgctggg atcgattgtg acggtcttta tcattccgaa ggtccgtcat 470941 aaggtgtggc gatatgaagt ccatgaacat gaaatagata ttcagtcagg tatttttgtg 471001 gtgacacgtg tgattgttcc gatggtcaga gttcagcacg tcgatacgtc acaagggcca 471061 ttattaaaaa aatacaacct ggcaacggtg aaaatttcca cagccgcgac cgttcattcg 471121 atccccgctt tagagatgga ggaagcggat cggctaagag actccatttc ccgtctggcg 471181 agggtgactg acgatgatgt ctgaaccgaa acgcctgcac ccggtggcag tcattttgaa 471241 tttatgccat accattattc aaacgataaa aaatatcatt ctgccattct tttttgtgta 471301 tattgtcaat tcaaaccata ctgtccgttt ttacggagcc attgcgctcg gtgtgctgtt 471361 catctggctt gtagcggcaa gcattatcaa atggagaagg tttacctatc gaattgaaga 471421 tgatgaattt agaattgaag aaggcttatt tgttacgaaa aaacgataca tatcgattga 471481 tcggattcaa acaatgaata cgagcgcggg ccttgtccag caaatcttta agcttgtgaa 471541 gctgcaaatt gaaacagcag gcggaggcaa ggaggcagaa gccgttcttt ctgctatttc 471601 tgttgaagaa gcggaacgca tcaaagaagc tgtctttaag aaaaaagcgc aaagacgaga 471661 aaatgaactt gatgaagaac ggcttgaagc tgaagaggag ttggatccgt ccgttgaggt 471721 gcaagagcac tatcgcatga acgcgaaaga attgctcatg gccgcttcta cctccggcgg 471781 aatcggagtc attatctccg ctgtatttgc acttatttcc cagcttgatg aagtgctgcc 471841 gatggattgg ttattcgata aattttcctt ccttcagcac gccagcatcg gtatttatgc 471901 ggtactcatt tttatcggtt tatttatcgc ctggattttc agcatcgcgg gcatgatgtt 471961 tagatacgcg aactttcaaa tcataaaaaa agagcaggaa ctggtgattt caaggggaat 472021 tattgaaaaa catcaagtca cgattccgct gcgaaaaata caagccatta aaatcaaaga 472081 aaatatcatt cgccagcttt tcggctttgt aacggtgtcc atcgtcagcg caggaggcgg 472141 cgaccgggaa aaagaagaag gcgctttgac cattctcttt ccaatgattc ataaaaaaaa 472201 gcttccgcac atgctccgaa catttacgcc ggaatacacg ctggaagaaa actgccgccg 472261 cctgccgcgg cgcgcgttga aacgctattt gttccgttct gtcatttttt cactcttttt 472321 gatcatcccg ttatgtatct tctttcagcc atggggctat ctgtcagtga tcctgctgcc 472381 gatagaattg ctcttcggct atctcgcgta taaagaggct gcatggacga tcaacgggga 472441 ccgtcttcag ctgacgtcta gatttatagg cagaacaacc gccattgtac tgaaaaaacg 472501 aatgcaggtc tgcaagttca gccaatccta tttccaaaag aaaggccgct tgtataccat 472561 ttctacttcg gtgaaatcat cgagccatat ggaagagtta acggtgaggg acgtaggtga 472621 agaggatgca gccttcattt taaagtggta ctcatatgaa aaagcggacg gttaataccg 472681 ccgctccagc gtgtcggcaa accctcgcat tcgttgtcag gactgcgctt cggtgctcaa 472741 tgcgaagtgg atcaacggct aaattctcag gcgtcctgcc taaacgccgt cgtcatcaca 472801 tcctgtgaaa gtccgctcct atgctcgtcc ttcctagact tcatgggttt tcaatcacgc 472861 tgaaaagatg acaaaatcct aaaatgaaaa ccattttagg attttgtcaa caatctgaag 472921 cggcggttaa taccgccgct cttttttttg cacgcataaa aacgaaagaa gaaacccgcc 472981 gcatagtcca aacaaatggg ccatcatgtt aatattggag ttgataaacg acatgagaac 473041 ggcaaatgcg agcagtgtga tgatcatttt ggaatgctcc tgcccaatta actcattgcg 473101 aaaaagaacc ataaacaggt atacgccaaa tagcccgaaa atggcgcctg aagccccgac 473161 atgcacgtaa tcaagcggct ctgtaacata agtgccgata ttgccgatga tgccggagcc 473221 ggcgtataca agaaggaaac gcgcttttcc cagcatgcgt tccaaagccg gggcaaataa 473281 aaagatggac atggaattaa acagcagatg tgtgaaaccg gcgtgcagca aaatcggtgt 473341 gataagccgc caccattcac cgtttgcgac acctagatta tagcctgtga cggtatccct 473401 ccataacacg actgaatggg caggaagtga aaaaaacagc cagagaacag cttgcaaagc 473461 caatataaag gtgacaacgg ggtaaagcct gataaatgtt tgaaaatttt cagtccgtat 473521 aaacattccg agcccctttt cttcattttg gtatatctat agtaacacgt ttatgagaca 473581 aaccatttaa atagtacgta cgcaaaggag gttatcatac atgatttacg gcattgggct 473641 ggacattacc gagcttaaac ggatcgcctc tatggctggg cgccagaaaa ggtttgccga 473701 gcggattttg acgcgaagcg agcttgacca atactatgag ctttcagaga aaagaaaaaa 473761 cgaatttctc gcgggcagat tcgcggcaaa agaagcgttc tcgaaagcat ttggcaccgg 473821 cattgggagg cagctcagct ttcaggacat tgaaattagg aaagaccaaa atggcaagcc 473881 ctatatcatt tgtacgaaac tgagccaggc cgccgttcac gtatcgatca ctcatacaaa 473941 agaatacgct gccgcgcagg ttgtgattga aaggttgtca agctagtctg catattaggg 474001 aaaccccact catatatttg atagtgcatt aagggagaca agttgtttga ggcttttatg 474061 gtacgcatct gttctgccta aacgtgtacc gagcgtaccg ttaaagtcaa acaagcgatt 474121 tcttcctttt acatcaattg agaaaaaggg gttgaaaaag gtgagaaaaa gctttgtttt 474181 gcttttaacg ggactgcttg ctgttcttat tctttctgcc tgcgggcaaa aaacacagca 474241 agatattgtg gccgggttag atgaaaaggc gaaagaatac acctcgtaca aagcaaaagc 474301 gaaaatgacc atcgagacag ggagtgagcc tcaagtatac aatgtggaaa tctggcacaa 474361 aaagccgtct ctgtacaggg tttatttaga aaatccgaaa aaggaccaaa accaagtcat 474421 tttacgaaat gaaaacggag tattcgttct cacgccgtct ttaaataaga gcttcagatt 474481 tcaaagcgat tggccgaaca acagcagcca ggtttatctg tttgaatcgc tcgtaaagga 474541 tgttcaaaac gattcggatg cagttttcac agcgaaagaa aagaaatacg tatttgaaac 474601 aaaaacaaac tatcagcata acaaaatgct gcccacgcaa gaaatcacat ttaacaaaaa 474661 agatatgagc ccgtcatctg tcaaagtgat ggatactgac cggaaagtga tggtcaaagt 474721 agaattcagc agctttgaat ttaataaaca atttgataaa gaatcatttg atgaaaagaa 474781 aaatatgacc ctttctcaaa tggatgtcgc cacaagcgca aagccttccg atacatttgc 474841 ggtcaaaacg ccgctggaac tgccgcttgg cgtcaagctg cttgaagaaa aagatatatc 474901 tactgaagac gggaagcgca tcatcatgac gtacggagga gaaaaatcat ttacgttaat 474961 tcaggaaaaa gcccagattg ccaaggcttc ctcctccgtt acgctgaacg gcgaaccggt 475021 aaatctcggc tacaccatcg gcgccctgtc ggatgcatca ttatcatgga catatgacgg 475081 cgtagattac cttctctctt ctaaagatct ttctaaagag gaaatggtga cagtagcgaa 475141 aagcatgcag ggacaatcat cgaaataacc gccaaaggcc aaacatgatt tggccttttt 475201 ttcgttagac atcgtttccc tttagccttt aattttagta tgatatgtaa atgatattga 475261 ataaaagcta ggaagtgtcg taatgagcac aaaacctttt tacagagata cgtgggcgga 475321 aattgacttg tccgcgataa aggaaaatgt cagcaatatg aaaaaacata tcggtgaaca 475381 tgtccacttg atggcagttg tgaaagcaaa cgcctacggg catggtgatg cagaaacagc 475441 aaaggctgct cttgacgcag gtgcttcatg cttggccgtg gccattttgg atgaagcgat 475501 ttcactgcgc aaaaagggat tgaaggcgcc tatattggtg cttggcgcgg ttcccccgga 475561 gtatgtggca atcgctgctg agtatgacgt gaccttaaca ggttattctg ttgaatggct 475621 tcaggaggca gcccgccaca cgaaaaaagg ttctcttcat tttcatctga aggtcgatac 475681 ggggatgaac agacttggtg taaaaacaga ggaagaagtt cagaacgtga tggcaattct 475741 tgaccgcaac cctcgtttaa agtgcaaagg ggtatttacc cattttgcga cagcggatga 475801 aaaagaaaga ggctatttct taatgcagtt tgagcgcttt aaagagctga ttgctccgct 475861 gccgttaaag aatctaatgg tccactgcgc gaacagcgcc gctggactcc ggctgaaaaa 475921 aggctttttt aatgcagtca gattcggcat cggcatgtat ggccttcgcc cgtctgctga 475981 catgtcggac gagataccgt ttcagctgcg tccggcattt accctgcatt cgacactgtc 476041 acatgtcaaa ctgatcagaa aaggcgagag cgtcagctac ggagccgagt acacagcgga 476101 aaaagacaca tggatcggga cggtgcctgt aggctatgcg gacggctggc tccgaaaatt 476161 gaaagggacc gacatccttg tgaagggaaa acgcctgaaa attgccggcc gaatttgcat 476221 ggaccaattt atggtggagc tggatcagga atatccgccg ggcacaaaag tcacattaat 476281 aggccggcag ggggatgaat atatttccat ggatgagatt gcaggaaggc tcgaaaccat 476341 taactatgag gtggcctgta caataagttc ccgtgttccc cgtatgtttt tggaaaatgg 476401 gagtataatg gaagtaagaa atcctttatt gcaggtaaat ataagcaatt aacttaccta 476461 aatggagaat tcataaaaca gctttgcttg aagagtgaat aatggtatca ttatcactgg 476521 atggataaaa gagtcgtatc cgtaagtttg gtggaggtgt atgttttttg tctgaatcca 476581 gcgcaagaac cgaaatgaaa atcagcttgc ccgaaaacct agtagctgaa ttggatggtg 476641 tagcgatgcg ggagaaacga agcagaaacg aactgatatc acaagcagtg agagcgtatg 476701 tcagcgaacg aacaactcgt cacaaccgtg atttgatgag acgcggctat atggaaatgg 476761 cgaaaatcaa cctgaatatt tcttctgagg ctcactttgc ggagtgcgag gctgaaacga 476821 cagttgagcg cttagtcagc ggaggataat catttgattg tgaaacgcgg cgatgtttat 476881 tttgctgatt tatctcctgt tgttggctca gagcaaggcg gggtgcgccc ggttttagtg 476941 atccaaaatg acatcggaaa tcgcttcagc ccaactgcta ttgttgcagc cataacagca 477001 caaatacaga aagcgaaatt accaacccac gtcgaaatcg atgcaaaacg ctacggtttt 477061 gaaagagatt ccgttatttt gctggagcaa attcggacga ttgacaagca aaggttaacg 477121 gataagatta ctcatctgga tgatgaaatg atggataagg ttgatgaagc cttacaaatc 477181 agtttggcac tcattgattt ttagacatat ttgcaggttg ctcaaataga gcaacttttt 477241 ttgttttcaa aaaacataaa cgatataata gtgaaataac gaaaaaatat gttgtttttt 477301 attgggaggt aagcgaattt gatgtcgaac cagactgtat accagttcat tgccgaaaat 477361 caaaatgaac tgctccaact gtggactgac acactaaaag aattaagcga gcaagaatcc 477421 tatcagctga ctgaccaagt gtatgaaaat atatctaaag aatatatcga cattctgctg 477481 ctgtctgtta aggacgaaaa tgctgctgaa agccaaatca gcgaactggc gcttcgagcg 477541 gtccaaatcg gactgtctat gaagtttttg gctactgcac ttgccgaatt ctggaagcgt 477601 ctctacacga aaatgaatga taagagattg ccagatcaag agagcacgga attaatctgg 477661 cagattgatc gctttttcag cccgattaac acagaaattt ttaatcaata ctcaatctca 477721 tgggaaaaaa cagtatccct gcaaaaaatc gcgctgcaag agctgtctgc gccgcttatc 477781 ccggtgtttg aaaatatcac tgtgatgcct cttgtcggaa caattgatac cgaacgcgcg 477841 aaacgaatta tggaaaacct tcttaatggc gtcgtcaaac accgttccca agtcgtgctg 477901 attgacatta caggtgtccc tgtcgtcgat acgatggttg cccatcatat tattcaggca 477961 tcagaagctg taaggcttgt cggagcaaaa tgcctgctgg ccggaatccg tccggaaatt 478021 gctcaaacaa tcgtcaacct ggggattgat ttatcccaag ttataactaa gaataccctg 478081 caaaaaggaa ttcaaacagc attggaaatg acggatcgaa aaatcgtttc attgggggaa 478141 taacattttg agacatccga aaatcccgat cttgaaactg tataattgct tattagtgtc 478201 cattcagtgg gaacttgatg accagacagc attaactttt caagaagact tattaaataa 478261 aatatacgaa acaggtgcta acggagtcgt cattgacctg acatctgtgg atatgattga 478321 ttcatttatc gcgaaagtgc tgggggacgt cattacaatg tctaagttaa tgggggctaa 478381 agtcgtcttg accggcattc agcccgctgt ggcagtgacg ctgattgaac ttggaatcgc 478441 gcttgaggaa atcgaaactg cgctcgactt agagcagggg cttgagacat tgaagcggga 478501 attgggggaa tagcgaatga acgaccaatc ctgtgtaaga atcatgacag aatgggatat 478561 tgtggccgcc agacagctgg gacgaaacgt tgcgaaagaa ctgggtttcg gcacggtaga 478621 ccaggctaga attacaacgg ctatttcaga attagccagg aatatttatt tatatgccgg 478681 caaagggcag attggaattg aacaggtcgc agacagagga aaaaaaggcc tgaaaatcat 478741 agcggaagac caagggccgg gaattcctga tatccgaaaa gtcatggaag acgggttttc 478801 aacgtctgga ggacttggtg cgggacttcc cggggtcaaa aggctgatgg atgaattcag 478861 cttaaattcc gtagcggggg aaggaacaga gatacaagcc atcaaatggc ttcggtagga 478921 ggtaagaacg tggattttag ggaggttatt gagcagcggt atcatcagct gcttagtcga 478981 tatatagccg aattaacaga aacatcttta tatcaagccc aaaaattcag ccgaaaaaca 479041 atcgagcacc aaattcctcc ggaagaaatc atcagcattc acagaaaagt gctgaaggag 479101 ctgtatccaa gtctcccgga agatgtgttt cattcgctgg attttttaat agaagtcatg 479161 attggctatg gaatggctta tcaggagcat caaaccctta gagggataca gcaggaaatc 479221 aaatcagaaa ttgaaatcgc ggcaaatgtc cagcagacgc ttctcggaac taaagttcct 479281 caggaggaag cgctggatat cggcgccatc agtgttcccg ctaaacagat gagcggtgat 479341 tactaccact ttgtcaaaga caaggaatcc atcaatatcg caatcgcgga cgtgatcgga 479401 aaaggcattc cagcggcttt atgcatgtcc atgattaaat acgcaatgga ctctttgccg 479461 gaaacgggca tacacccttc tcaagtgctg aaaaatttga atcgtgttgt tgaacaaaac 479521 gttgatgcca gtatgtttat tacgatgttt tatgcgaatt acaatatgga caagcatcaa 479581 tttacatatg cttcagcggg acatgaaccg ggattctatt attctcaaaa agacaacacg 479641 ttttacgatt tagaggccaa aggactcgtt ctcggcatct cgcaggacta tgactacaaa 479701 caattcgatc agcatctgga aaagggcgat atgattgttt tattttctga cggcgtcaca 479761 gaatgcagaa cggaaaacgg tttcttggag cgtcctgatc tgcagaagct cattgaggaa 479821 catatgtgtt cctctgcgca ggaaatggtc aaaaacattt atgacagcct cctcaaattg 479881 caggattttc agcttcacga tgattttacg ttaattgttt tgcggagaaa ggtttaacgt 479941 ctgtcagacg agggtataaa gcaactagtg atttgaagga aaatttgagg tgatacgaat 480001 gaatataaat gttgatgtga agcaaaacga gaatgatata caagtaaaca ttgcaggaga 480061 aattgatgta tactcagccc cggtgcttag agagaagctc gttcctctgg cagaacaagg 480121 agctgactta agaatttgcc tgaaagatgt cagctacatg gacagtaccg gattgggcgt 480181 ttttgtaggg acctttaaaa tggtgaaaaa acaaggtggt tcgctgaaac ttgaaaatct 480241 ttctgaacgg ctgatccgac tgtttgacat tacaggcttg aaggacatca ttgatatttc 480301 tgcaaagtca gaaggtggag tgcaatgaag aataatgctg attacatcga aatgaaagtg 480361 ccggcccaac ctgaatatgt gggaattata agactgacgc tgtcaggggt cgcaagcaga 480421 atgggctata cgtacgatga aattgaagac ttgaaaatcg cagtcagtga ggcgtgcaca 480481 aatgcggttc agcacgctta caaagaagat aaaaatgggg aagtgtcaat acgattcggt 480541 gtgtttgaag accgtttaga ggttattgtg gcggatgaag gagacagctt tgactttgat 480601 caaaagcagc aggatctagg gccgtacaca ccttcgcaca cagttgatca attatcagaa 480661 ggagggctcg gtctatattt aatggaaacg ctcatggatg aagtcagagt gcaaaaccac 480721 tccggcgtca ccgtagcgat gacaaagtat ttaaatgggg agcgagttga tcatgacaca 480781 accatcaaaa actacgaaac taactaaaga tgaagtcgat cggctcataa gcgattacca 480841 aacaaagcaa gatgaacaag cgcaggaaac gcttgtgcgg gtgtatacaa atctggttga 480901 catgcttgcg aaaaaatact caaaaggcaa aagcttccac gaggatctcc gccaggtcgg 480961 catgatcggg ctgctaggcg cgattaagcg atacgatcct gttgtcggca aatcgtttga 481021 agcttttgca atcccgacaa tcatcggtga aattaaacgt ttcctcagag ataaaacatg 481081 gagcgttcat gtgccgagac gaattaaaga actcggtcca agaatcaaaa tggcggttga 481141 tcagctgacc actgaaacac aaagatcgcc gaaagtcgaa gagattgccg aattcctcga 481201 tgtttctgaa gaagaggttc ttgaaacgat ggaaatgggc aaaagctatc aagccttatc 481261 cgttgaccac agcattgaag cggattcgga cggaagcact gtcacgattc ttgatatcgt 481321 cggatcacag gaggacggat atgagcgggt caaccagcaa ttgatgctgc aaagcgtgct 481381 tcatgtcctt tcagaccgtg agaaacaaat catagacctt acgtatattc aaaacaaaag 481441 ccaaaaagaa actggggaca ttctcggtat atctcaaatg cacgtctcgc gcttgcaacg 481501 caaagctgtg aagaagctca gagaggcctt gattgaagat ccctcgatgg agttaatgta 481561 atgatccagg ttgaagaaaa cgagcatatt caaactctag tatatcaact gaataaagaa 481621 gggaaatcga tttgcggtga cagttttttt atgaaagctg atgataagga gttaatttgc 481681 gcggttgctg acggactggg aagtggatca cttgctaacg aatcctctgc agccatcaaa 481741 gacttagtgg aaaactatgc gagtgaagac gtagaaagca ttatcgaacg ctgtaatcag 481801 gcgatgaaaa acaaaagagg cgctacagca tctatcctga aaatcaattt tgagcaaagg 481861 cagtttacgt actgctctgt cggaaatgta cggtttattc tgcattcccc gtctggtgaa 481921 agcttttatc ctctgccgat ttcgggctat ttatcaggca agccgcaaaa atacaaaacg 481981 cacaccgcca cctatgaaaa gggttcaaag ttcattatac atacagatgg actcaacgta 482041 cctgatatcc gctcccattt gaaaaaaggc caatcggtag aagaaatatc gaattcgctg 482101 aaaatgtata cgacatcgag aaaagatgac ctgacctata ttctcggaca gctgtcctaa 482161 aaaaccagaa aaagaagctg gacatccggc ttcttttttt tgcggttgac tattaataag 482221 tgcgcttatt atacttaata agtgaactta tcattctggg agcttatggg atgtggaatt 482281 atgaatacac agcgatagct gatgtggatg tgggaaaacc tggaactgtt atcaggaaac 482341 agaaacaatg gatcaatggg agacgggtat tgcatcagat tctttgaaag gacaatttca 482401 aaatggaacg gaaggaacat tgcttctgca aggaaaaaca attctcttat ggcttgagca 482461 tgtggagaaa catcgggcgt tttctgtcat ggtcaacatg cccgcatagc aatgtaataa 482521 tggagttttt tcacgtgctt caaaagcaaa aagaagattt gtgtatcaca tatggaattg 482581 tattagaagg cgctgaagca aaaaagtggg gagaaatcat tgggactgaa ctgtctaaag 482641 acatgccgac ggctgtcagc aggcttgtcc atctttacgg aggagtgata aaatgaacac 482701 aaattactgg atcggcgttg tgtcagagca acatgtatta aaaggcgctg ccggcggttt 482761 tgcacagctg tgccatggaa aaaaagcccc gctcgccaaa atgaaagagg gagattggct 482821 gatttattat tctccgagag acgcatatcc agacggcaaa ctgctgcgaa gctttactgc 482881 gatcggcaaa gtaaaaagcg gaaacatcta tccgtatcaa atggctccga attttattcc 482941 ataccgatta gatatagact attatccatg ccataaaatc ggtttttacg acattaaatc 483001 aaagcttgaa tttgttcagg aaaccaagca tcttggcttt ttatttcgca gaggacactt 483061 tgaaataagc aaaaaagatt ttttgacaat agcacaagcg atgggagtta acataagtgg 483121 aatggcactc taaatttagc ggtccgaaca caagcccggg ctttttatta tggcaggcca 483181 cgcaaagttg gcagcggaaa gtaggaaaag cattggctga gtttgacctg acccacgttc 483241 aatttgttct gctgacctcg tgcaagtata tgattgctca cggagaaacc gtcacgcaaa 483301 aaaaacttgc aagcttcagc cagaccaata tcatgatggt ttcggaggtt gtgcggacgc 483361 ttgagaaaaa aggatttatc gaaagaagca aaaatcccca ggataaaaga gaggtcctcc 483421 tgtctcttac agaaatagga ggagaaaaag taacagcggc tttgccaatt gttgagaaga 483481 ttgatcaagc cttctttgca gctgcgatga aaaaagagaa ttttctgagc ggcttacagg 483541 aactattgaa acatgagtaa agatacgggc agcgccagct gtcttttttt atgtgttttt 483601 ttcggttttt gatacactag agaaagaacg acaaaattgg aggctttggt tacatggaaa 483661 cgtcagccct tttaaaacag caaattgcga aagaaatagg tttatcacaa aaacacgttg 483721 aaagtgtcat ccgcctgctt gaggacggca atacagtccc gtttattgcc cggtatcgaa 483781 aagagcagac gggttcaatg gatgaggttc agattcagac gatttctgaa cgctggcaat 483841 acatacaaaa cctgaatcag cgaaaagaag aagtcatcag gctgattgca gagcaggata 483901 aactgacaga taatctaaaa cgtaaaatcg agcaatcggt gaagcttcag gaagtggaag 483961 acctttaccg cccttataaa caaaaacgta aaacaaaggc gacagtcgcc aaaagcaaag 484021 gccttgagcc gcttgccgac tatatcctga cacttcccca agatgatcat ctggcagcaa 484081 ctgcagacca atacatcagc gaagaaaaag aagtgttcac acgagaagaa gcgattgaag 484141 gcgccaagca cattattgcg gaacaaatct cagacgagcc gaccttcaga aagtggattc 484201 gccaggaaac cttcaaaaga ggaaccatta agtctgcagc cggaaagtcg gcagacaccg 484261 atgagaaaaa tgtgtatgaa atgtattacg agtatgaaga gccaattgca aaagttgttc 484321 cgcatagggt gctggcaatg aaccgcggcg aaaaagaaga cattttaaag gtagcgatcg 484381 aaccgcctgc ggatcacatt aaggcgtatt tagaaaaaca aatcatcaaa aatcgctcaa 484441 catccgtaag agagattttg caggagacaa ttgaagacag ctataaaagg ctgatccagc 484501 cggcaatcga gcgtgaaatc aggaaagagc tctcagaaaa agctgatgaa caggcgattc 484561 atattttctc agagaacttg agaaagcttc ttttgcagcc gccgatgaaa ggcaaaaccg 484621 ttctcggtgt tgacccagcc tttcgaactg gctgtaagct cgctgtgtca gatgagaccg 484681 gaaaagtctt gaaaattgat gtgatctatc cgcatgcgcc agtcaacaaa acaaaagaag 484741 cccatgaaaa agtgaaaaag attcttgagc agtatcaagt cgagatggtg gcgatcggaa 484801 acggcacagc atccagagaa acagagcaat tcatcgtcaa tgtactcaga gacatgccgc 484861 gcaaaattta ttatgtgatc gtcaatgaag cgggagcaag cgtctattcg gcttcagagc 484921 ttgccagaga agaattccct gaccttaagg ttgaagagcg cagtgccgta tctattgctc 484981 ggagacttca agacccgctc gcggagctcg ttaagatcga tccgaagtct gttggtgtcg 485041 gacagtatca gcatgacgtc agccaaaaac gcttaaatga atctctgcgg tttgtcgtcg 485101 aaactgtcgt aaaccaggtt ggagtaaacg tcaacacagc ctccgccgcg ctgcttcaat 485161 atgtagctgg attatcgaag tctgtagcag gcaacgttgt caaaaaacgt gaggaaatcg 485221 gaaagttttc aaatcgaaaa gaactgaagg acatcccaag gttaggtgcg aaaacctatg 485281 agcaatgtat cggtttctta agagtgcagg aagggacaga gcctttggat agaacaggca 485341 tccacccgga aagctataaa gaaacaaaag cacttttgaa aaaactcgga ctttcaacag 485401 aacatatcgg cacggcggaa ttgaaggaca aaatcaatca gctggcgctc tctgaaacgg 485461 caaaagagct gggaatcggc gaaatcactc tgaaagacat ttgtgaacag ctgacaaggc 485521 cggaacgcga tccacgcgat aaggtgccta agcctttgct gaaaacagac gtccttcagc 485581 tggaagattt gaaagaggga atggaactgc agggcaccgt gcgcaatgta gtggacttcg 485641 gagcgtttgt tgatatcgga gtcaaacaag acgggcttgt gcatatctca aaattgagca 485701 atcaattcgt caagcatcct cttgatgtcg tatctgtcgg cgatattgtg acagtttggg 485761 ttgacggcgt agatgtacaa aaaggcagag tatcgctgtc tatggtaaaa taaaagcact 485821 gcttacgagc agtgtttttt cctatagaaa taccagcatt gattcagcag tttaatttgg 485881 taattatctt tttcaaggaa cgctttttgc atctgctttt taagccaatt tggcataggc 485941 tcattcctcc tcagctttta tcataagagg gacagtgatt accatattgt atgcgaacgg 486001 tgaattgtcc cgttcaatgt tttttaagtg aggtgcacca tggataacaa agagcttcaa 486061 aagctgacag aggatatttc tgaaacatat tttaaaaagc cgttccgcca tcaggcgctt 486121 tttaatgacc ggcttaaaac cactggcggc aggtacctgt taacctccca taacattgaa 486181 ttgaacagaa aatatttgat tgaacacggc agggaggaac tgattggcat catcaagcac 486241 gagctctgcc attatcatct tcatcttgaa ggaaaagggt acaagcacag agacagagat 486301 tttagaatgc tattgcagca ggtcaacgcg ccgaggttct gtacacccct taagaaaaaa 486361 gcggaaaaca aaaaaactta tatgtatatc tgtacgacct gcggccaaca gtatataaag 486421 aagcgcgcca tgaaccctga cagatacaga tgcggaaaat gccgcggaaa aataaaaaga 486481 attttttcgt gaaaaaggtt gacgaatatg gcaagcctat gttacattat aaaagtcgtc 486541 acgagagata aataaaaaca tttacctctt gacactgcaa atcaaggctg atataataag 486601 tcttgtctca ttattccaca gtagctcagt ggtagagcta tcggctgtta accgatcggt 486661 cgcaggttcg aatcctgcct gtggagccat attggagaag tactcaagtg gctgaagagg 486721 cgcccctgct aagggtgtag gtcgcgtaag cggcgcgagg gttcaaatcc ctccttctcc 486781 gccataagat ttcgatataa gttctcaacc atcggcccgt tggtcaagcg gttaagacac 486841 cgccctttca cggcggtaac acgggttcga atcccgtacg ggtcattcca tttcgttggg 486901 ctatagccaa gcggtaaggc aacggacttt gactccgtca tgcgttggtt cgaatccagc 486961 tagcccagcc atttttattt ttgaaatcta atagtaagag ccattagctc agttggtaga 487021 gcatctgact tttaatcaga gggtcgaagg ttcgagtcct tcatggctca ccatttgtct 487081 ttttgcgggt gtggcggaat tggcagacgc gctagactta ggatctagtg tcttacgacg 487141 tgggggttcg agtcccttca cccgcacttt atttacaaag tgcacgcaaa tctgttttac 487201 taggttaaga gcctactaaa ccagcacaac acaatttaat gatcacgcgg tcgtggcgga 487261 atggcagacg cgctaggttg agggcctagt gggtgaataa cccgtggagg ttcaagtcct 487321 ctcggccgca tctcaataat accaagggtt taaccacctt tggtattatt tttttgtgtg 487381 gaaaatacgg ctatgggaga agacttgctc accaaaactc accagttact taaagtaagt 487441 catccaaacg gtcggcggtt ccttctgttt attaggaaaa agatatccgt tcattgtaaa 487501 agaaacgaac catgtcctat tcgttcaaaa aaactaaagg gtgatacata ttatacatga 487561 ttaatatgta tcaccctttt ctttcttgtt caacaatcgc gcttgaggag aacataagct 487621 aatacaactg actcgatttc taaagttgct ccattctttt tttaaacaac tcatccacaa 487681 cctgttttaa aatctcgtac gactgaattt ccttgctcaa ttcgtaaata ttagataaca 487741 caattaattc atctgcgtga tacatttgtt ggaaatcaat tagttcgcga cgaattgttt 487801 ctcgatcacc catgattgta taccccagtc gactgtggag aatttctaat tcaaactgtg 487861 ataacgattc taggaagttt tcagtgggtg gaataagctt acttaaatta tttgtataaa 487921 tatcaatata cacctgcaaa tgacttgcag aaataaaaga tgcctcgtct atagattctg 487981 ctgcaatcac attaatgcaa gcgatcacat aaggttcttg taaataagaa gacggttgga 488041 aattttctcg ataaatagag agcgcttctt ccatcgaatg gggtgaaaat tgagcgccaa 488101 atgcataggg taaaccaagc tttgcagcaa tttccgctga atccgttgag gatcctaaca 488161 caaaaacagg cacatgcgtt ccaatacccg gataagcgcg aacctcaccc tgtacactct 488221 tatccccgac aaaacgcaaa atatcattta cttctctttc aaagaaaaac actccattat 488281 ggttggaacg acgaatcaca tcggccgttt tttgatccgt tccgggtgcg cgtcctaatg 488341 ccaaatctac acgatttgga tataatgttt caagtgttcc aaattgctcc gctacgatta 488401 atggggaatg atttggcaac ataatacccc ctgaacctac gcgaatgtct tttgtatttg 488461 ctaatatatg ttgtacaatt gatacggttg ctgcacttgc ataagcgtcg tgattatgat 488521 gctctgcaaa ccaaatccgt ttatagccca tattatctac agctttagct aatgacactg 488581 cagaatcaat cccttgtttc attgtttctc cttgtcttaa tggagcaact gataaaacag 488641 atatatcaaa ttttttcata atttcacctc taaaataatg aacttataca agatcaatgg 488701 aaaaaacatt ttgaaaaatt gtttcatatt aaatggtgtc cattcctctt tgatttgcat 488761 gcaaataaat atatactttc tcaaacgatc aatacatagg caaaataaag ttatttcaca 488821 atttcacttt acttttaaag ttttaagcaa acataaaaaa atgttcagtg aacaaaatat 488881 gtaaaataca tcttattttt cagaaaggat acaagaaaat gattgatgaa atagataaaa 488941 aaatacttga tgagctgtct aaaaatagtc gccttacaat gaaaaaatta ggggaaaaag 489001 tacatctcac tgcaccagca accgcatcaa gagtagtaaa gttaatagac aatggcataa 489061 taaaaggatg tagtatcgaa gtgaatcaag tgaaattagg cttctctata catgcttttc 489121 ttaatattta tatcgaaaaa atccatcatc aaccctattt agcttttata gaaacacaag 489181 ataactatgt aataaacaat tataaagtta gtggagacgg ttgctatttg cttgaatgta 489241 aatttccttc aaacgaggta ttagatcaat ttttaaatga cttaaataaa catgcaaact 489301 ataaagtgtc gattgttatt ggtaaatagt taactttata aaacggagat gtgcggtcat 489361 ataacatgat atatatgctc taaaaaagcc ctaggttgga tatggaattt accaagctgg 489421 ggccttttta tacattataa taacaagcgc attattcatc agacattaat gaagtattat 489481 aatgcttttt tacttcctta atagacaaat aaagctgata gtttccatac ttcaataaat 489541 cattcagaag gtgatttaaa acttcttgtg aatgaaccgt taccttcaga agataacatg 489601 catctcccga aacacgatga gcttcgctaa tttcattacg agtagcaata aatttcaata 489661 aatcatcatg catatatgca ttcatgaaaa agaagacaaa ggctgtaaaa gaaaacccca 489721 tcttcaattc atcaaccaca atcgaatatg ctttaatgat accgttatcc tccatttttt 489781 tgatgcgatt gcctaccgct tgtcctgtca tatgaatttt ttcaccgatt tctttccatt 489841 gtatccgagc atttttattt aataattgga gaatttgaaa atcaattgaa tcaatttgca 489901 tagtaactcc tttcacagtg aaaaagtttt acaaaatagt atttcatgag accatcgaaa 489961 attcaatgga aattatatat ccttatacag tataaaaatt ttaagaggtg aaaaaatgac 490021 aacagcttta ttagtgattg atattcaaaa tgattacttt ccaaatggga agatggcttt 490081 aacaaaccca gagaaagcag cacaaaatgc ggctaaacta ctttcacact ttagaaacac 490141 aggcgcacct gtctttcatg tacagcatat cacagaaggt aacatcgctc attttttcca 490201 tccaaataca gaaggtgtcg aaattcatga gtcagtacgt ccattagaga aagagacagt 490261 cattgtaaaa catatgccga atagcttttt caatacagat ttaaatggaa agctacaaga 490321 agaaggggtt aaagaattag ttgtttgcgg tatgatgtcc catatgtgta ttgatgcaac 490381 agttcgttct gcagttgaac atggttatgt atgccaagtg gtagaagatg cttgcgcaac 490441 aacaacattg caaattgaag ataaaatcgt tcctgctgag catgtccatt acgcatttat 490501 ggccgcatta aatggtgtct atgcaacagt aaaaaccaca gaggcatttt taaaataaaa 490561 gaatttcctg cgcgaacata acgtctttct tttcacaaga aagatgattc aacaacttaa 490621 aaaaggatgt tcagaaaaat acttctggac atcctttatt cattatcttt tattgttttt 490681 cagtatcatt attcccatct gataaaagat caagatgtcc tgtttttgat ccatagtaag 490741 accatataca gggattgttt ttgccataaa tatagatatt gatgaaggtt tacataaagc 490801 acctaattgc ttgatttact ttaatgttag atccctcaat aactccattc tcttctaatt 490861 tctctactct agctgtagct gctgggcatg ttaaatgtac tctctcccag atctttcatt 490921 gaattcggct attatacata atttctctat aattttttat ctgtttgatc tatttgaacg 490981 ttaattcctt tcgaaaataa agtcaaagag ttaaaacact tttttttatc tatgtattcg 491041 aacactgctg atattataca cttaactctg tcgatctaag acaaataaaa aaagaaagtg 491101 agttgtaaat atgaatatta cacaaattcg aaatgcaaca attgttgtaa aatacgcaaa 491161 taaaaaattt ttgatagatc ctatgttagc agagaaaggt acgtacgcta ctttccctga 491221 aacgatcaga caagatttat ttaatccttt ggtgagtttg ccaacatcaa ttgataacat 491281 tctggatggc gtagatgcgg taattgttac tcatctacac ctagatcact ttgatgatgt 491341 ggcaaaaaac gtattgccaa aaaacatcaa aatgtttgtt caaaatgaag cagatgcaaa 491401 agaagtaaaa gcaagtggtt tcaaaaatgt agaagtgcta catcaagaca ctgtttttga 491461 agggatccaa ttagtaaaaa caaaaggtga acatggcaga ggggaagagt tattaaactt 491521 aatgggtgat gtttgtggat tagtattcaa gcacccaagt gaaaaagttt tatatgtagc 491581 tggggataca gtttggtatg atgctatcga agacgagatt catacacatc aaccagaaat 491641 cattgtggtt aatggtggag acaatcaaag attagattta ggttcactca tcatgggaaa 491701 agaagacatc tatgaagttc acaaggctgc tcctcatgct aagattatat ctgttcatat 491761 ggaagctgtt aaccattgga cactatctag agaagaatta aaaaacttta gtaaagaaaa 491821 aggattctca agtaatattt tagtgccaga agatggcgag tcttacacat tttaatatga 491881 acaccgacaa ataaatagaa gaagctcata attataaaaa ctaatcatga gcttcttcta 491941 ataatgaata ttttaaattt taaatatatc gaaaatccta aatatacgga ataacaaaaa 492001 tggaatgttc caatgatgac aaaaaaactt gaaaagcaac aaagatgtgt cgttaggagg 492061 tagaattcat ggtaatgaca aaaaaagata caaatatatc aacacagcag cctctttggt 492121 tacaaggtta tattgattca ccagaaaaac aaaaccaact ttataaaaaa acattaaaaa 492181 tcttgatttt ttcacaaata tttgggggag caggacttgg agctgggata acagttgggg 492241 cgcttcttgc acaagatatg ataggatcgg aaaatgtagc aggaattcca actgccctct 492301 ttacttttgg atctgccgta gctgccctgc ttataggagc atcctcacaa cgttttggtc 492361 gcagagctgg acttgcaggt ggtttcctta taggcggatt aggtgctata ggtgtgataa 492421 tcgcggcttt aattaacagc gttgccctat tatttgtttc tcttcttatt tatggagcag 492481 gtatggcttc taatcttcaa gttcggtatg ctgggacaga ccttgcaaat gagaaacaac 492541 gggcaactgc tgcaagtatg gccttagttt ctactacttt aggagctgta gtaggtccta 492601 acttagttaa tacaatgggg gaatttgcag attcaattgg tgttcccaat ttagctggtc 492661 cgtttattat gtcaggagca gcttttataa ttgctggaat tattctctta atttttcttc 492721 gtccagatcc gctgtttgta tcaacagcta ttgcgaatgc tgagaaaaaa gacgataaag 492781 tacaaatagg aggaagtcta aaaaatcctg ctatagacaa aaaaggaata atggtaggag 492841 ctgtcattat gattttagct caactaatca tgacagctat tatgacaatg acaccggttc 492901 acatgggtca tcacggtcat ggtttaagcg aagtgggatt agttatagga ctccatattg 492961 cagcgatgta tcttccttca ccattgactg gtttattagt agataagttt ggtcgcacaa 493021 ctatggctat tgcttcaggt gccacacttc ttgccgctgg gttggtggca gctattgcac 493081 cggcagactc attatcattg ctaatcctag cactagtatt actaggggta ggttggaact 493141 ttggtttact aacgggaact gcccttatta tagattcaac acatccatct ctacgtgcaa 493201 aaacacaggg aacattcgat gttttattag cactatcagg agcagcaggt ggagccttgt 493261 caggaatggt tgttgcacat tctagttata caatactatc aatttctgga gccgttttat 493321 cattgttact cattccagta gttatttggt attttagaag gattcaggaa aaagcataag 493381 cttatataac tgtctttgaa gaacctaagt agacattact ttaccggaac ctcctttttc 493441 tatttattat agtaaggagt tgacatggca ttagtggcat gtgtataact acacaattat 493501 ttgggattca gagagcatgt aatgaacgga agagataatt atttatcact tttattattg 493561 tacggtgttc ttgtggcatt aagttcagtc aattttggtc taactgtttt ctttttgttt 493621 tcatcacctc tccatattat taacaaacac gaaaaggatt ttaatgaaaa taaaatgatt 493681 agcgtatgta tctctaattt tcaaaatgaa tgaatagtcc tttttaagat ttacacactt 493741 attctccaag gaaaaatgac tcaatttttc gattttttat gtaaatcaaa aaagaatcat 493801 gttagagtag gtgtgctgaa aataattcaa aaaattattt tgcgatatga ttaaagtaat 493861 attgccagag agtttcaatt ggacaaaatt gtaagtgttt aatacactgg ggctgcaatc 493921 aaatatgcac ctggaatcaa ttgctaaacg ggggagttta tatgaacaac aagaaaaata 493981 tctttgatat tgttatgtac attattttcg gtgtgttaag tctttttcta gttgcaaaaa 494041 ctgattatgg cactggagtt ttagtgtttg ttgcaatttt atacctcgct gttattgctt 494101 ataaaattaa gcaagtattt agtaattcag attcttaagg tgtaacacaa ggaggatttc 494161 aattgagaaa gaaaagagtt attacttgtg ttatggctgc atcattgact ttaggctcac 494221 ttttacctgc aggttacgct tctgcaaagg aggactctaa gacaacccct tcttacgaag 494281 aactagctct acattacaaa atgaaaagtg aaaagatttc atcgaacggg aaattagttg 494341 aaattgagta tgtgagtgga aatgaaactc acaaagttca gatgaacgga aataatcata 494401 ctgtaaaagt cgatggcata gaacaaaaag gtttaaactt tgagtatgat gaaaatgttg 494461 ctaaaagaac aaattatgaa aacaataatt tgaaatcaaa tgaattcaca acacaggctg 494521 caaaacctaa aaagggatac cattatgtgg ggactttatc tgggcataca aaagcagcta 494581 aaaatgcgtt atcagttaca atgtcattag tcggtattgt ccctggcttg ggatggggga 494641 gtaaggctgc cactatttta ttctcttatt gggcaaaaga acaaatccct gatgcgtatt 494701 ataaatatga tttatacgaa aaaggagcaa tgactgatag ttggtatcag tatgctacag 494761 ttcaattttt tgaagataaa gctcataaaa agaaaatggg caaaccttgg acaagtactc 494821 ctgcaaaagt agatttacct aatagctaat tttaaaatca ctttgtcttt ataaaggaca 494881 aagtgatttt ttgttataca gaagtaaaat ccctcgtctg aggaatcttg gaaaaaactt 494941 ggttcaattt tgatataaca tgtttttttc ttgctaattt agtttttcta tgtatcgcta 495001 cacattctaa ataataagat attagccgga cggttgatgc caagctcaaa agtttatatg 495061 gaagtcaaag cataaaaaag ggtgttacaa cgtgtagtct tctttttatt ttgccaacgt 495121 aacaagtgtg aaagtaatga tttgtaggat cagttaagaa aggtttaaga ttagatattg 495181 aaaaatttta tatattttca ataaaatact ggtactataa taaatgtata cagattgtat 495241 ggagatgtaa ttaattaaaa aggagttttt taattgcgtt ggagtaaatg gttcaatgtt 495301 ttttgtatag tagcattggg atcaatatat ggttataaat tatttactaa ccaagaagtc 495361 agtactactc gtttaataat agcttctgta attgtgttgt ggaatattgt tggacttttt 495421 agcaaagaat cagtaaaaca agcacagcaa gcaaattaaa agtcataaag ttgggaaaga 495481 aggatgttac ttatgtagta tccttcttta ttattccttg aaaaatgaaa caaattggag 495541 attacagctt atataatcaa ttgaagtcgt tgattatttt catgaacagg agatttaatg 495601 ctttctgatg aaatattatc gtatgaatgt tgcaagagga aacgttactc aaagattaca 495661 gggatgtgat gaacactcct ctttatcgca ctcacctgac cccaaattgt tggggaaggg 495721 caggtacgga agatagagta ttttttcttc gtaacaaatc gaaaaggttg gataataaaa 495781 aacttataat ctaaggcggt atatagttgt gaaaaaggcg ttatttctta tattagacca 495841 gtatgcagat tgggaaggtg tttacttagc atctgcatta aatcaaagag aagattggtc 495901 ggttcacact gtttctttag accctattgt aagctcaata ggtggtttta aaacatctgt 495961 cgattacata atagggttag aacctgcaaa ttttaatttg ctagttatga ttggcgggga 496021 ttcctggagt aatgacaata aaaaactatt acattttgta aaaactgcat ttcaaaaaaa 496081 cattccaata gcagcgatat gcggtgcagt ggattttttg gcgaagaatg gtttgctgaa 496141 taatcatagc catacaggta attttgttta cttatggaaa gattacaaac aatataaacc 496201 gattagcagt tttgtagaga aacaagcagt aagagataaa aatttggtta ctgctaatgg 496261 aactgcccct attgaattta ctaatttaat tttagagatg attgattttg atactcctga 496321 gaacatagag aaaatgatgt atatgaatcg ttatggtttt tatcattttt gtgataaata 496381 tggaaatcca tttgttgatt aatttgctgg aaatgatttt cccgaatagg gggctttgcg 496441 attgagttga atttcctaat aaagcaaaga aagatgattt gaggtcaagt ttaacaaata 496501 atgccatcaa tattaatttg cagttatttc cgattcctga tataataaag aagaattatt 496561 tttgttcggt gtaaaggata gtatgaagat tgacttttcg tcttgatgat actttgggca 496621 aggatagtat atactgtgtg gttacacact aggaggcaac aaaaatggaa caaggtacag 496681 ttaaatggtt taatgcagaa aaaggttttg gctttatcga acgcgaaaat ggagacgatg 496741 tattcgtaca cttttctgca atccaaagtg acggattcaa atctttagac gaaggtcaaa 496801 aagtatcgtt tgacgttgag caaggtgctc gtggagctca agctgctaac gttcaaaaag 496861 cttaatcttc aatcgtttat acaaacaggc tctttatata gggcctgttt ttttatgtct 496921 atatcatact caataaaaaa ccctactcaa cgttcgagta gggagatgct acaaggtaat 496981 agaaaaagat ttaaaacttc aaaggtttgt ttacagtata acatactgga ttgacaatat 497041 gcggaatgta tataaattat ttaatgtttt gttcaaatat agataactga ctcttttttt 497101 cactaacctg ttcgttcatt taagtaagat tagatgaatt ataaaaatgg tttcatctaa 497161 atgttatcaa ctcgcatatc tcttttatga gaagaagata aacaattatt attcaatgtt 497221 gcagtggata taagaaattc ttaaaaataa tgaggagatc gattgttttt ttctcctgga 497281 aataatcact tagagatacc taaaacaatg aaagccctac ctctcttcca tccttacggc 497341 tccttgtccg tgccagtgtg aatcaggata ctaaaaaaag tgactatttt attgagtttt 497401 ttggtaaaac ttcaatcttc gcagaagaaa tgtaaataat aaaaatggat tagaatgtag 497461 gaataacaaa agaggtcgtt aatgttctaa acataagttg gagaagattt gcttttcatc 497521 ataatattcc gaaatatctt ttgggatgta tctaaccaaa actttttatt tgtttttcag 497581 tgattccttt aattacttcc agttcactaa tcaaaaattc atatgcatta tccagcattt 497641 ttttttcgct tgcattaagt gctttttctt tcttcatacg cattaaatca cgtacaactt 497701 cagcaccttc ttgtatttca cctgttttta ttttgtccgt gtttattttg tacctttgct 497761 tccatggcag taacctatcg gattctccat gctgaaaaat gtgcataatg tgttttaatg 497821 caagtatatc ggtaactggt cgtatattcg aactcaatat tttactcgtt ggaatcataa 497881 ctgtcatatt actgattgac attcttatga cataatactg ttgtttttcc tctaagaatt 497941 ctttttcttc tatggcttca attatacctg ctccgtgcat tggataaaca atgttatcgc 498001 caatttgaaa catatcatcc acctccatat atggtatcct tcttaagatt accatatatg 498061 gaggtgtaat atcaaaattt taataataac atgatcgaat ttttgatgtc aataactttt 498121 ttgaaaaaac agatcaagca aaaacaatag ggaacgtgtc ggatttccaa tcaggaaaag 498181 gtcaattgat ccgtgtgagc agtttttcat tggctcaatg acattacaga aatgatttga 498241 gtagataaga aagaacgata ttcgtgaaat gtcagctaaa aatatttaaa gcacatgatt 498301 aagttctaat ttctttaccg atttgatatg gataacggcc gacttactta atgatgcatt 498361 ttcacttatc ttgcaagcag aaaaaggttt gttgataaac atttagccac caaattggca 498421 ttattatcag ggaaattgac aaccttcaaa tgggtattga ggcgagaaga aaaataaaga 498481 aaggagagat tataaatgaa gaccagaaca taaagaagta aaggggaaag aacaaggtta 498541 attgaaaagc aaactatata aaatagtttg cttttttttg ttatgacttc acttcttttt 498601 ctttctcttt aatgactaat aaaacaccgc tcagaattaa aaacgaacct atccaaaatg 498661 tcccgcctat ttgttctcca agcagaatcc atccgagtaa ggttccaacc agaggctgaa 498721 aaaagaaaaa gaggcctcca cttgaggcat ttaataattg taagccgtgg ttccacaata 498781 aaaatgcaca agctgttgaa acaattccca aatacaaaag gccacctaga attttagggt 498841 caagcagtag tggcgtaaaa atcgtgctag gggagtacca ttaacaggga ctccatttat 498901 taatagaata aactttatga attcattttt ttgtatgata atggcgtcat attcatcgct 498961 tgttgaaatt tacttatgaa ataactggta ctgttaaatc caacttgata agacacttct 499021 gtcacattgg attcagggtg ttgcagtaat aataagcttt tttgaattct ataatccatt 499081 acataacgta atggcgtctt attcagcatt cgtttaaaat aacggcagca ttcagaacgg 499141 ctcagttggc cagcttttgc aatgtcctct aatgtgattt tttcaacata atggagatgg 499201 atccagttta acatttgttt cattcgatga ctttttatca tttcagattg atcgtactct 499261 aattgaaaac cattaacgac caggtttttc cacattaacg ttaattgcat cgtaatgtca 499321 atctcataga gcgatgtctt ttgttgaatc aattgattta tttttttaac agcatctaga 499381 atattttttg cccactgttg atttccagcc aaaaataaat agggcaaatt ggttgaaaac 499441 atatagggct gaacatagct tgaatacagt tcctgagata aaacgaaatg gggtgacaca 499501 ttcaagcaaa tatacgtaca atccgagcct tccttttctt cggccatgtg caggtagccg 499561 ctattgataa ataatccatc cccttcgtga acctctattt tttcttcatt tatttgaaag 499621 agagctatcc cttttagtat caaaacaaat tggatttcat catgccaatg aagcggaata 499681 tagccattta tattttgatt gatcgttgtc ttgtagcagg caactggcaa ttctaccgtt 499741 cggtgctctg ttaattcttt taaattttga tcgatcacaa aattcttcat tctgacttca 499801 cacctcaata tatttatatt ttttcattca atttgagtat tttttatcat gttttgcatt 499861 tattataaca ctattattat atttattagt gaggagtcat gtatgaatac ttccaataga 499921 agaatgggat tgttctatgt tatcacaggg gcgacatgtt gggggattgg aggcacagta 499981 gccaaaaaac tttttcaaga atatcaaatt gatgtcaatt ggcttgtaac gacacgcttg 500041 cttacggctg gaatgttact tttaatgctg caactgttca gaaaggatcg ttcccaggtt 500101 attgaggtgt ggaaacacaa agcgtcggct ggccagcttc taatttttgg cctattggga 500161 atgctagctg tgcagtacac atatatggca tccattcaac atgggaatgc tgccgttgct 500221 acgttattgc aatatttatc cccagtaatc gtcattatct acacgctgtt gcgaaaacaa 500281 acggttctta ccaaacaaga tatcataact gttgtacttg ctttagtggg ttgctttttt 500341 ttgttaacaa atggttcaat gtctcaactt tcagtgccgg cagctgcagt agtatgggga 500401 gttttatcag gattcgcggc agctttttat actttgtatg ccgttggttt attaaataaa 500461 tttgattctc ttgtcgttgt aggttgggct atgattattg gcggttttgc attgggtttt 500521 atccatccgc catggcaact ggattttcaa cgattaactg ctgaggcgta tgcatatatc 500581 ttattcgtga tattatttgg aacaatgatt gcgttctggt tcttcataaa aagcttggaa 500641 agcctctctc caaaagaaac aagcctacta ggcagtctag agcctctatc agctgttgta 500701 acaactgtcg tttggttaaa agcgccattt ggttcttttc aatggattgg tgctatttgt 500761 attataggga taactttaat attggcttta cataaagagc cttctatgga gagtgaaaaa 500821 tcgatattaa agattaggaa tcatgcaaat cgggatatat aggggctttt tttgcttaca 500881 tgaccggtcc ggcaatgaaa aacactggtg gagtttgagc cctctcggca gtatcaaaaa 500941 taccaagggt tttgacgccc taggtatttt ttcttcaaga accttcaatt tttcttctct 501001 gattgaaaaa cgtattactt ttttgtgatt ggtatccaaa tttcactttt aaaagatggt 501061 gatgttacat ccttatgctc gttccacaat atttctggac cttctatttg ttcgtaattt 501121 gacgatggaa accattcgga ataaatgcgt ccccatactt cttgcagtgt atccggaaat 501181 ggcccgattg attcgaatac agcccatgtt gaggcaggaa cttcaagccg tgagaagtta 501241 tctggacacc gtttcgttgt ggctgcgcca atatagtgat cgagctctcc gttttcctct 501301 gtccgacctt cagaaaaatt cgtggatgca ctaatgaggc ctgatggtgc tacattagat 501361 agctctttta gtttatttat tgctttttca tctaaacttt cccacataga tgcaatttcc 501421 ggattaattc ctttgaaaat aataggaact ctttttttaa tgccaacgat gcgaaatgcc 501481 tctttttctt caatacggta gttcatttca tttcctcctt taattgttag ctggaaggtc 501541 attcgtggat aagctttaag ggaatggcca ttaaatctgg cttttgatgg gtttatgcca 501601 tgtaaatttt ggaatgcccg tgcaaaagaa tctggtgagt tataaccgta ctttattgca 501661 atatcaatca cttttacatt gctgtctttc agttcaaaag ctgcaagagt aagacgtctg 501721 cgacgaatat attccgataa tgaaatacct gcaaggaagg aaaacatcct tttaaaatga 501781 tattcagagc agaaagcaag ctttgctgcc tcttgaaaat caatatcatt agtgaggttt 501841 tcttcaatat actttaacgc cctattcata cttttaagca aatccattta tttggcctcc 501901 tttaaccaaa gaataacagg agtgaaatgt atttatccga cattctgtgc acagttttgc 501961 aggatgactt atatgaaata aagtaagtga ttcacttgta tttgtacagg ttttattgaa 502021 gcatgctgtt cataaaaagg catcaataaa agaaagttat aattgtctta taaacggcac 502081 attcatataa ttgagtgaaa aaggatgcgt atcatgccta tcaattcttt tgaaaattat 502141 ccgatgagct ggaagccatc gattgataaa gctgaaaagc ctatttataa agcacttgca 502201 gggcaattgg aacaggatat tttaaacgga gttttattac ctggaacaaa acttcctcca 502261 cagcgagaat tggccgatta tctagattta aatgtgagta cgatttcaaa agcatttaaa 502321 gtgtgtgagt taaaagggct gctgagtgcg actgtaggga gcggcacatt tgtatcgtat 502381 gatgcgttgt cgaatgcgta tttacttgag gatactaagc cgacacattt aattgaaatg 502441 ggagcaatac ttccagatca cgcttcatat gagcccttgt tataccaact gaaaaacatg 502501 gttcatgagg aggattatga aaaatggttt agctatggcc gggcaggtga aagcctttgg 502561 caaaaagatg cagctgtaaa gctcatccaa agaggcggat ttgaaacatc cgttgatcac 502621 attttatttg caaatggagg gcaaaatgcg attgcagcga cattggcgag tctttgtaag 502681 cctggagatc gcatcggagt tgaccatcat acgtaccctg gattaaaaac tgttgcatca 502741 ttgcttagtg tgcaaatcgt accgataaaa tcagaaaacg atgaaatgag tccggagtca 502801 cttgaatatg cgtgtaaaaa cgaaaatatt aaaggtttgt atttaatccc ggattatcat 502861 aatccgacga cttcctttat gtctgttgag aatcgaagaa tggttgcaga cattgtaaag 502921 aaatataatc tgtttgttat tgaggatgca tcgtaccatc ttctcaacaa aaatccgctt 502981 ccggcactcg cctcattcgc accgcaacag gttattcata ttgcaagttt atcaaaatcg 503041 ttagcgccag gcctgcgttt ggcttatgta gcagtgccga gacaatataa ggagccaata 503101 tcaaaggcgc tttataattt aaatataact gtttccccgc tattagctga acttactgct 503161 cgcacgattg tatcaaatca atttgaagtc ttaattgaga gtcatcgtga acaaaccatt 503221 cgcagaaatc aactcgtaaa ccgatatgtt gcgggatata catgtttagg tgttgaaaca 503281 ggcatttttc gttggttgtt gttaccgggt aaaatgtctg gtgccgaatt tgaagaattg 503341 gctgctcgac ttggcgtgca agtgtatgcg gctgaacgct ttgtagtggg aaatagttgt 503401 cctgaaaggg ctgtaagggt ttctgtctgt gcaccaaaaa cacttgaaga gcttgaacaa 503461 ggattaatga tcctgagacg tttgctagac gatcttacct aatattgttt gccatacaat 503521 tatgacattg tatggctttt ttgtgcgtgt tatgatgatc cacatctaga gggaggttta 503581 tacaaaattg gcttttagaa aggaaggtca gatgatgtta gacaaggaca gcgtaaaagc 503641 aatagatgtt caaactgctt cattacagag ctacatcagt tcaccagaaa aacaaaaatc 503701 gttatacaag cgtacactat tcgttgtgag tatctcacaa atttttggcg gtgcggggct 503761 ggcggcagga gtgactgtcg gtgcgcttat tgcacagcaa atgcttggca ctgatgcgtt 503821 tgctggtttg ccttctgctt tatttacttt agggtcagca ggatctgcat taattgttgg 503881 aagactttct caacgttatg gccgtcgaac aggtctttca gctggcttta tgattggcgg 503941 acttggagca ataggcgtta ttatggcagc aatcataaat agtattttct tgttatttat 504001 ttcgttgctt atttacggtg caggtacagc cactaattta caggcccgtt atgcaggtac 504061 agacttagca aatcataagc agcgagcgac tgctgttagt ataaccatgg tttttactac 504121 atttggcgca gtggcaggtc caagcttagt gaatgtgatg ggggatttcg ctctttctat 504181 tggtgttcca tcacttgctg gccctttcat tttagccgca gcagcatata tgttagcagg 504241 tgtggtcctt ttcattatgc ttcgtccaga tccattagtt atagcaagaa caatagaagc 504301 ggcaaatgaa gagcctggtg ataaaggaca tttggcggca actgagcata cagaaaacaa 504361 aaaagggata atcgttgggg caacggttat ggttcttacc caaatagtaa tggtagctat 504421 tatgacaatg acaccggttc atatgagaca tcatgggcat gacttgggtg cagtcggtct 504481 tgttattggt tttcatatag gtgctatgta tctcccttca cttgttacag gtgttcttgt 504541 agataggttg ggacgtaccg caatggctat ttcctctgga acaacgttgc ttttggcagg 504601 tgtaatagca gcatttgctc cgggagaatc tatgattctt ctcgtcattg ctctttcttt 504661 actgggatta gggtggaatt ttggtttgat aagcgggact gcccttattg tagattcaac 504721 tgatactgcc acacgagcta aaacgcaggg gacagtggat gttctgattg cgttgtcagg 504781 agctgctggc ggagcattat ctggaatgat tgtggcaggt tcaagttacc tcgcattatc 504841 acttattgga gggattttgt ccttattact cattccggtg gtggtatggt ctaggggccg 504901 ctaaagggta ggattgttta atttacatta atttgttata ttgttagata aagtatattg 504961 cagcatctaa tattctaacg aactatagtt gctccattaa atctattata aagatttgac 505021 caggattcct tatagctgtg tcactcactg catattcttt aattgaatca cataaaatgg 505081 ttatcggatt tgaaaaaggc aggattactc gctttaggta aaggagtcat aacgttgtta 505141 aaaaggtttt ctcttgttat tgttacacta atgatgtcta tcgttgttgt tttagcggct 505201 gctaaagagt cgcctggaga tcatgtcatc tcatttgatg aacctattat cttgatgatc 505261 tcaattggaa tcgttgtatt tttattgatc cctccattag tcatgtcctt ttttggcaat 505321 ttggttgtaa gaataatatc tggtgtatac caatgtttta tcgttttcac ttttctgggg 505381 ctcattccaa ttggatttct tattcccaat ggctttttga caattctagt ttctattgca 505441 ggaactttag tcagtatagc tagtgttgcc gtaaccttat gcattggcaa gaataaaaaa 505501 gatatataat catcgaattg ttattttttc agattgtcag tgaaataatt atacaaaaag 505561 agaaggcttg tgggccttct ttttttgttg ttgcatcatc cccactttga gcttaatcta 505621 ttgaataata agagaaggaa cctatagaag aataaaataa ataccgagat gtcaaaaata 505681 aaactggact tcattattgt gaattcacgt aaatgtaaaa agattggaaa gaggggaatt 505741 ccttcatgac aaatagcaga acaaatccga aggttgatga atttttaagt aaagcgaaaa 505801 agtggaagga agaatttgag aagttgagaa ccatcattct tgactgtgag ctgactgaag 505861 attttaagtg gatgcatcct tgttacacat atcataataa aaatattgtt ttaatacatg 505921 ggtttaaaga atattgcgcg cttctgttcc acaaaggcgt cttattacag gatacagatg 505981 gaattctcat tcaacaaacg gagaatgtac aggcggcgcg ccagattcgg tttacaaatg 506041 ttcaggaaat aaatgagcta gaaaacattt tgaaagccta tattcacgaa gccattgaag 506101 ttgaaaaagc cggtttgaaa gtggatgtta acaaaaatat tgaattgaac attcctgaag 506161 aacttcaaaa taaattcgat gaaatccctg cattgaaaat tgcttttgaa gctttgaccc 506221 cgggacggca aagagcgtac actctttatt tttctcaagc caaacaatcc aaaacccgag 506281 aatcgagagt cgaaaaatat gtgcaaaaaa ttctcgatgg aaagggatta aaggattagg 506341 cacgccaagg ttcaggctaa aggaatagca tcatagcgta ataagatcat ttctatagaa 506401 gaaaaacaag catagtaaga tgcttgtttt ttcttaggac aacattcact tactgctgaa 506461 atgcttctaa cattgtatgc cactagacag cgttataaaa tattaatgca acacctagaa 506521 atctatccaa tgaaatagct caatggtatg gctcattaca tttagaatgc ctaggagaac 506581 taatagaacc ggaagatttt tagcaagtta ctacactcca aactttgttt ttgtattaat 506641 ataccttatt aaccattgtt tttagtcagg tgcagacaaa cgaatactga ttaatgaatc 506701 atcatgatat caatgagccg cttgattttt tcatcgtcgc ctgtatcaac gtacactgtt 506761 tttctgtttt ttatgatact ctcagtcact tcccgcatga cgcctttttc tatatcatca 506821 gcggaatccc agcgtaaagg cacattatat acatgaattg tgccatcccc attgccatga 506881 taagtgactg atccatccac taaacgagaa cctgccaact gggtcacatt ttctggatag 506941 ctggcacttg tatcatcatt aggattaatt ggctcgccag ccgcaatatg tcgaacattt 507001 aattcatcta tctcttgatt aggtccaagt tgaagccaaa ctctggcata ttcaattttt 507061 tccgaagagt atgctgccaa tacattgtct tctttgcttt tctcttctgc tgaagaggta 507121 tcatttgcag cttttgttgc ggattcttct gattctgtta ttggctccgc ttcatccttg 507181 cgtattttgg tgctctcttc aggctcagtg tgtttttcgt cagtttgcac agcagaagct 507241 tgatttgaag gttgttgtgc ttctccatcc ttactgtccg tacatccagc aagcaaaatc 507301 ataagcagca gggcagtatt gcaataacat atctttctgc gtttcttcat tttttcattc 507361 ctctctatta attcaggtca gcttcatata taagtttatg tatctaaata ttaccatgga 507421 atagatagga tgatattgaa aactgtttaa gaagaggaaa cgatcttgaa tagcatcgcg 507481 aaaacctaag aatcttaaga agttttgccc ctttttcttc aggtattgaa tgtaaagtgg 507541 gatataaatg caaacaaaaa cgaaatgcct tatccacctc gtgtcatggc agaaaaagtg 507601 ggggatttat tagagcggat ttgataatgg cggcaggtaa atgggtgttg acttatatgt 507661 ctaagcggga gactcaagtc tgctcgatcg catacaaaat accaagggcc agcaaccctt 507721 ggtattttta taccttcatg catttttgaa gtttatgctt aaaggtctgc cttactttgc 507781 aaatcgccga gctgctgcaa cgcacatgat aacggcgata ttcactgcta cgagtgccca 507841 gcccactttc tcgtgcagaa tcactgaggc aagcagcagt ccaaaaaaag gctggagaag 507901 ctggagctgc ccaaccgctg caattccccc ttgggcaaga cctcgatacc agaacacgaa 507961 gccaatcagc atgctgaata aggatacata tgcaagactg agcagtgcgg gaacgccgat 508021 cgccgaccat gagtccggcg taaaaaagaa cgacaatggc agcataagag gaagcgacag 508081 aacgagtgcc catgagatca cctgccaatt ccccagacgc cgtgaaagtt tggccccttc 508141 tgcataacca agaccgcata cgacaataga agccagcatg tacgcgtcgc caagcgggga 508201 tgaacctccc ccctgaatga gggcgaaacc tgctactaac aagctgccgg cagctgagaa 508261 aatccagaag acggggcgag ggcgttcacc cccgcgcagt acgccgaaga ctgccgttgc 508321 gagtggaaga agtccaatga agacaatggc gtgtgcggat gtgacatgct gaagcgctaa 508381 agctgtcagc aacgggaaac caatcactac gccgaacgct accactaaca atgaaatgag 508441 atctcttttg gcaggatgct gctgccggaa gatgagaagg agacctcccg ccagtacacc 508501 agctatcgca gcacggcaaa ctgtgagaaa taacggatcg aagtctgaca cagccaaacg 508561 ggtcgcaggc agcgagccgc tgaaaatgag tacgcctata aaaccattta tccagccatt 508621 tgttgttttg ttcattataa tcactccaca tatctttctt gttcattgtc tgtattttct 508681 taacaaaacc agcagctaag gattacaatg actataaact ggaattggcc ttttataaac 508741 agccagtttt cataaaaaaa tgcataccag ttaggagaac aacgcgcaaa tggatatcac 508801 gccttttttg aatagaactc tggatattcc gctttatcag cagctttatc ggtattttaa 508861 agaaaatatg catcggggcc gtattcaaaa aggaatgaag cttccttcaa aaagactcct 508921 ggcgaatcag ctttccatca gccaaacgac tgtagaacgt gcctatgaac agctcgctgc 508981 tgaaggttat attgtgagca agccaagaag cgggtggttt gctgattatc atgattctga 509041 ttttgcttat gatagaatgc caagcacaac acccattcaa caagaagcag aagaaaataa 509101 acaatggatt gattttcatt atgggaatgt agattcttct tacttccctt tttccgcatg 509161 gcgaaaaagc atggtcaata gcttagacca atatggacac gagctttatc ggccgggaca 509221 tgttttagga gagtttgagc tgagaacact cattgcagag tacctgtatc aatctcgggg 509281 ggttcattgc ggccctgaac aagtgattat aggtgccggg aaccctattc tgctgcaaat 509341 cttgtgccaa gtttttgagc cgaatatttc tatagggtat gaggatcctg gttatccaag 509401 agcacgcaag atttttgaag ccaaccgcat gaatattgtt cctataccag tcgatgatga 509461 gggaatctgt atacagaaga tcaaagaaca gcagccaaac cttgtatatg tcacaccttc 509521 ccatcaattt acgctgggaa ccataatgac aataaacaga agaattcagc tgctcaaatg 509581 ggcggccgaa aatcaatcct ttatcataga ggatgattat gacggggaat ttaggtacac 509641 aggacagccg gttccttctc tgcaagggct tgatcagcat aaccgtgtca tttatatggg 509701 cactttttct aagtctcttt tgccctcgct gcgtatcagc tatatgattc ttccttcgcc 509761 tcttttaaaa aagggtcatg aaatcacgtc cttatataag cagacagtgt cctgccacag 509821 tcagctaacc ctagctgaat ttataaaaaa tggagagtgg caaaaacaca tcaacagaat 509881 gagaaaactt taccgcaaaa aaagagccat tgtattagag gcagtgcaaa gggaattagg 509941 agagcatgtc agaatccgcg gagaaaactc tgggcttcgt atcttacttg acgtttattt 510001 gccatttggt gaaaaagagt taattgagaa ggcgaaaaaa catggagtaa aaatttatcc 510061 tgtttctctt tcttatcaac atcatcctcc tacaaaaacg gtctcgctcg ggtttgcagg 510121 ggtttctgaa tccgacataa gagaaggcat aaaaaaactg aaggctgcct ggaagatatg 510181 agggagcttt cagtttagca aaacggccaa gtgacgacta agtgttgaga gctgttcaat 510241 attttttaag tatatgatga gtgcctgcag tccaggccac gatacgtctg tttagcgaaa 510301 aacagaattt tttatttgct cctcacagtg ctaaaataaa caaaatagac aattgaaaaa 510361 atagaggtgt aagaatgaag ttagatgagt ttacaattgg ccaggtcttc aaaacgaaat 510421 cattaaaagt atcaaaagat gatattatgc ggtttgcggg tgaatttgac cctcagtata 510481 tgcatgtaga tgaagaaaaa gcgagtaaag gcagatttaa tggaattatc gcttccggca 510541 tacaaacact ggccatatct tttaaacttt ggattgaaga aggtttctat ggagacgata 510601 ttatagccgg aacagagatg aatcatatga cattcataaa acccgtatat ccggatgatg 510661 aattgtttac aattgttgag gttcttgata agcagccaaa gagaaatgaa ttgggaatac 510721 tcacagtatt gctatctact tataatcaaa aagaagtaaa agtgtttgaa ggtgagttat 510781 ctgtattgat caaacgataa ctcagaaagc ccgcttttcg cgggctcgat tgaagcagat 510841 gggtgaaaga tgttagcggg tttcctttga aaaataagag gttaaaacat cataaacaat 510901 aggcaaagaa gtaaatccct catcttctag aaaatgacct ccgtgctgaa cttcatataa 510961 cgcagcatca atttgttgtg ccagatcctt gctgaatgaa aaaggcacaa tttggtcgtc 511021 cttagaagca atgacagcac ggtgcttcgc ggactcgatg attttttgat gatcaaacga 511081 tccctgtgta aattcatcta acatctgtaa agtgggcaat gatttggcaa agccggaaac 511141 aagtatgatt ccgccaagct gttttcgtaa ttgaagatgt tccaaaaatc tcaaaatggc 511201 ggggcaacct aagctgtgcg caaccaaata cgtattttca tgtaaagtgt gctgatataa 511261 agagagtgta tccagccaat cctcaagtct tggctggagc ggattaggca tgtttaaaat 511321 gtctgcttgg accccatctg cgagcagacg ttttttcagc caagggaacc aatgatttgt 511381 tgaggaggct ctgtagccat gaatgatata gacttgtttt gtcattattt cctcctaaga 511441 aatattttca ttcagtataa aattcctctc attgggaaac aagtacgcac ttttttgtaa 511501 gtagctttac atatgaggcc ctccttgtgc cattccccac ttacacatct catctatgag 511561 gggatacaaa gatcgccctc tgtcagataa cgaatactct actttcagtg gggtgtgaga 511621 aacctcagac cgatgaataa ggccgtcagt ttgcaattcc ttaagctgtg cgcttaacat 511681 tttatgggtg atgaagggca tagccctttt cagctcgccg tatctcatcg ttttttcaca 511741 ccctaactca tagagaattc tcattttcca tttgccccct ataagagata aggtgtattc 511801 aaatggggct tgtttactgc ggcacaggct attcattgta atcaaacctc cttttttaag 511861 tatcatatca gaataaatta ggattttcgg tgttgaagtt tgagggcgat tcacgatctg 511921 aagtgaaagg ggccgcttgc tcaacaggcg gcacggtaca tgaatgttct aagtcaaaga 511981 gggttacctt actgttagtt actttattta aaaaaacgca tgtttttagc tgaaaatatc 512041 tattatggta tatttaaata taaagaaata tttgagaaat gaggaatggt atgaatacac 512101 ccaaaaaaca taagaaattt aaagcgaaaa tgattctcca aatcatcatg gttatcattg 512161 gaggaatcat agcggcatat ggactagaaa cagtgctcat tccaaacagt gtatctgatg 512221 gaggggtgac gggtcttagc atcgttggtt cacagctatt caacttgccg ctggggattt 512281 tgattgctgt gatcaacatt ccatttgtct ggttaggata taagcaaatt gggaaaagct 512341 ttgcattatt atcaattatc ggaatcgtat cgcttgccgc ggggacaagc tttttccacc 512401 acacacccgc tatcatagaa ggagataccc tgttaattac cgttgtcggc gggattatcc 512461 ttggattcgg aatggggctg gcgctgcgta atggcggcgc attagatgga attgacatgc 512521 ttgctgtgct gctatcccga aaactgccat tcggaacgag cgatctcatt ctattcttaa 512581 acctatttgt gtttattttt gtttccacag tatttggctt acaaggggca ttgctttcag 512641 tcattgctta ctacattgca tccaaagtga ttcatgttgt ggaggaaggc ttaagcggct 512701 ctaaaacctt tcaaattatt acaacccaac ctgaattaat ggtagagaca atacgtgatc 512761 aattaggccg aagcgccaca tataaagaag cttacggggg tttttcccac gagaaattta 512821 aagaaatcac atgtgtcatc aaccgtttag aagaaaccaa actaaaggaa attattaatg 512881 atattgataa aactgccttt gttaccgtgt atgatgtagc tgaagtgaag ggcagcaatt 512941 ttagaaatct taatcatcac taaaaaatag aatgaccttt ttaaccgtaa ctgacatgcc 513001 gcgggtaatt taatcaaaaa cacttttttg aggcttgtgg gtgaataacc ggtgaaggtc 513061 tgaatcacag aaataccaag ggcgtcaaaa cccttggtat tttttctggt tattagattt 513121 tatcttcagc tttacgtgct gcttcgagct tatcaatcct gtctttatat ttttctcccc 513181 agtccttcat gtgcaggata acaggttcta atgttcttcc aaactcagtt aaagagtatt 513241 cgacttttgg agggacctgt ttataaacct cgcggtgaat cacgccatcc cgttccaatt 513301 ctcttaattg tagcgtgagc atacgctggg taatttttgg gtatagtttt cgaaactcat 513361 taaacctctt tttaccgtca atgagatgat aaagaagaat gcctttccac ttacctccga 513421 tgatatctaa tgttgtctcc accggacatc cttcaaagtc atcagaagaa taatcaatgc 513481 cgagtttacg atttctcaag ctgttcactc ctaatagtat actttttgat actatataca 513541 ttcaatgtgc gtacttttta tattttaata tacatcatat aatgatgtca catctaagga 513601 atgaaaggaa tggatcatat gaaaacactc gtactcgttg tacatccgaa tatagaatcc 513661 tctcgtatca ataaaaagtg gaaagaagcc gttttaagtg aaccagatgt aactgtccat 513721 gatctttatg aaaaatatcg cgatcaacca attgatgtgg aatttgaaca acagcagctc 513781 ctggcccatg accgtatcgt ttttcagttt ccattatact ggtacagcag cccaccgctt 513841 ttaaaacagt ggtttgatga agtgtttacg tttggctggg ctcatggtcc cggcggaaat 513901 aaattgaagg ggaaagagtg ggtaactgcc atgtccatcg gttcacctga acactcttat 513961 caagccggcg gatataactt gttttcgata agcgagctga caaaaccgtt ccaagcatct 514021 gcccatttag taggcatgac ctatctgcct tcctttgccg aatatcgcgc caatacaatc 514081 agtgaccaag aaattgccga aagtgcgaat cggtatgtaa agcatattac aaatatagaa 514141 ttaaacccga aggttcgcct gcaaaggtat ttgaaacagc tggagagtgt cgatttaaca 514201 taaagattga tttttgaaaa tcctgtactc accaagcagg attttttctt gttcagcaga 514261 gggattttaa catatagcaa aaaaagaaga agccaccaaa aataagctat ttgcttggtc 514321 ctgactgctt atttttggtg aaatacttat ttctctgtga tgaaataaag caaagcgatg 514381 accggaaaag cgattccaat ccataatgct gtactccatc cgcctgaggc atatgcccat 514441 cctccaattg atgaccctat cgcaccgcct agaaagaaga tcgccatgaa taatccgttt 514501 aatcgactgc gaatttcagg cgccaacgaa aaaatagcac gttgactgag cacaaggttt 514561 gcagatacac ccatatctaa cagaatagca gcggccacta gaactgttat accgacgggg 514621 gagctgctct gaatcatgag cggcagtaat aaagagacaa cgacaacacc gagagcgatt 514681 ccagtggcaa gcctggttaa gcctcgatca gccaggcggc cgcctattgg tgcagtgact 514741 gcacccgcaa tgcccaccaa tgcgtagagt gctattgcct tctgagaaaa atgaaaatca 514801 ggaccggaca ataataaagg aacagttgtc cagaacaagc tgaaagctcc aaatacaaac 514861 gcatgataga tggcacggcg gcgtaagact ggagtcgtgc gcagcagctt ccacattgaa 514921 ccgagtaagg cagtatagtt tgtatttgct gttggttttc tggcaggaag cacttttgat 514981 aatacgatgg ccaggataac acttaccacg gcggacaaag cgaatattgc attccacccc 515041 cagatatcag cgactagact agatatcgga cgggaaagca taataccgag taataagccg 515101 ctcatgacat tgccaacaac ccggccgcgt gcagcgtctg atgcaaggta tgatgcaaat 515161 ggaacaagca cttgggctgc gattgatccc aatccgacga aaaacgcagc tgctaaaaac 515221 agtgttccat gcttcacaaa tgctgttagt gtcaaagccg ctgcgcttag aaggagcgat 515281 acaacaataa gttttttgtt ttcgataata tctcctaaag ggacaaggaa tagtaagccg 515341 gcaacgtatc cgatttgggt gagtgtgaca atcaatccag caccgcttgg agaaagtcca 515401 attgccttac taattaatcc gaccaagggt tgtgcatagt aaagattagc aacaatgata 515461 ccgcatgcag ttgcgagaag aagggttaaa ctgggtgaaa tcctctgacc tgcttgtttg 515521 tttccattag ccatatgaat gaactccttt ttaagtggtt ttttgagtgt aatcatgact 515581 tctcacaagt gattttataa actgaacgtt cagtttcgtc gattaataaa aataatatac 515641 taaacgttca gttttgtaaa tggatttctg ttttcttttt ttattcaatt taagtatact 515701 gaacgtatag tttatattgc gggaaggaat gatttatgtg cagagtaaac gagggcggcc 515761 gcgtgatgaa ggaacgcata aggcgattct ctctgcagcc tatgacctat tgctggaaaa 515821 aggcttcgat gcggtgacag tcgataaaat tgccgagcgt gcgaaagtga gtaaagcaac 515881 gatttataaa tggtggtcta acaaggctgc cgttatcatg gacagctttc tttcgaccgc 515941 gacggacagg ctgcctgtgc ctgatacagg gtcgtcagta caagatatag taacccacgc 516001 cacgaattta gctaggtttt tgacaagccg ggaaggaacc gttattaagg aattaatagg 516061 tgcagggcag ttggatgaaa aattggcaga agaatatcgc acgcgatttt tccagcctcg 516121 ccgcctccaa gcgaaaggcc ttctagaaaa gggaattcag aaaggtgaat tgagagagaa 516181 tcttgatatt gaagtaagca tagatctcat ttacggacca attttctatc gtctgcttat 516241 aacaggggat gaggtgaatg attcctatgt gcgtgatttg gtgatgaatg cgtttaaggg 516301 agttcaagct acctctgcta cagagagtat gtagctgata agaactgcaa aagctgcgga 516361 ttatatgaca aattggttcc atcgtacagt gaaatataag atttttgttg ctgagcggaa 516421 tcatcgaggg aaaagttctc ttatcggatg tcgaaaaaga agtcattcaa tcgtgaatac 516481 ataacatcat attattacat tccttttcat cgattggaac aagggttcta tacttcaatg 516541 gaataccgca aagttggagt atttaaacaa caggggaaaa tcgatggcca ttatgtaggt 516601 gtcatggcaa tggaaaaaat acttgcaatg taaacaggcc tctaaagaga cctgtttttt 516661 aatatccaga tgattgtcta gtttcagctt gggctctatg accactccca taactgaaat 516721 agtctaatat ttataccaga agggattgtt tatataaata aaagtttata taatgacggg 516781 ggcgctaagg aaacgcgggg agcgactcag gttttcgttt caaagttttg atccttaaga 516841 tatacggagc gctacatatg gaaacgtaaa ggggaatgta taatcatttg gcgtgtatat 516901 aacgatttgc ttatatattg atttgggaag gaggagctca tatgacgatt gatgttgcgg 516961 cgatgactcg ttgtttgaaa acacttagtg atcaaactag gcttatcatg atgagattat 517021 ttcttgaaca agaatattgt gtctgtcaat tggttgatat gttcgaaatg agccagcccg 517081 ccataagcca gcatttgcgg aaattaaaaa acgcaggttt tgtgaatgag gacagaagag 517141 gccaatggcg ttattattca ataaatggtt cctgtcctga gtttgataca ttgcaattga 517201 tcttacatca aattgatcaa gaggatgaat tgttaaacca tatcaaacaa aagaaaactc 517261 aagcgtgttg ccagtaagga ggcattagat tgacatcaat gattttggca gtattcatct 517321 ttttattaac tctagtattg gtcatatggc agccgaaaaa tttatctata gggtggtcag 517381 cctgtggagg cgcagtttta gctctaatag caggtgttgt caattttcat gatgtgttaa 517441 ctgtgacagg gattgtttgg aatgcgacct tggcttttgt ggccatcata ctgatatcgt 517501 taattcttga taatatcggt ttctttgaat gggcagcgct tcatatggct aaggctgcaa 517561 aaggatacgg tgtgcggatg ttcgtttatg tatctctatt aggagctatc gtcgccgcgt 517621 tatttgcaaa tgacggtgca gctcttatat tgacaccaat cgtattagcg atggtcagag 517681 cattacattt taatgaaaaa ttagtttttc cttttatcat tgccagcgga tttattgcgg 517741 ataccacttc gcttcctttt gtagtaagca atttggtcaa cattgtttca gcggactatt 517801 ttcatattac gtttattgat tatgcatcca gaatggttgt cccgtacctg ttttcgctgc 517861 tggcgagcat cattgtactt taccttttct ttagaaaaag cataccaaaa cgctatgatc 517921 tgactgaggt taaaaaacct gttgaagcaa ttaaagatca aaacatgttc agactgtcat 517981 ggtatatctt agggctgctg ttaattggat attttgcaag tgaatttttt tctatccctg 518041 tatcagtggt agcgggcagc attgcaatca ttttcttaat cgctgcgcaa aagagtccgg 518101 ccgtccatac aaagaaagtg gtgaaagagg cgccatgggc tatcgtattc ttttcaattg 518161 gcatgtacgt tgttgtgtat ggtgtccgaa atgccggatt aacggatgtc ctttcagatg 518221 tgattcaagc cgcagctgat caaggattgt ttgctgggac aattggaatg ggctttattg 518281 cggcgattct ttcttccatt atgaataact tgccgactgt tatgattgac gcattggcca 518341 ttgccggtac agatacacat gggatgatga gagaagcgct tatttatgca aatgtgatcg 518401 gttcagattt agggcctaaa ataacaccga ttggttcctt agcgacatta ttatggcttc 518461 atgttctttc gcacaaaggt atgaagattt cctggggcac gtattttaaa acaggaatta 518521 tcctcacgat acccacttta ttgatcacac ttgtcggcct gtatatttgg ctgctgataa 518581 tccattcttg tttctaaaag gacaaggtca ctatatcaag gaaaacaatg cactggtaac 518641 tcttgccgca gccaaatggc tgaagggtgg gggagaaaat accttggggc taagtggaat 518701 gtgtacagcg caggaatcga agctcaagga tgacatcgag tgctgtcaaa gcaatgaaag 518761 aagcagggat tgatatttca aatcaaacat cggagaaatt tgatgatccg gcaaaagcac 518821 acggaacaga agaagtgttt ccaaagggtc cgtgatgaaa ttggtgaccg tttaaaacag 518881 tttgctgtaa ctggggaata aagaatcgat atattcagcg ttttcttggg ttatataata 518941 caatgtgttg ttcaacaggt gtctgcgagc tgagtgcaga cacctgtttt tgtttttatt 519001 tgtctgagat tcgtaacagg gaagttattt agctggtgac agaggaaaat tgatttgtga 519061 acagaatcat gaaggagacg gtgttttaaa ggagttgtct gttttgcagg aattaacaaa 519121 aaaaaaatac agtagcttaa aaacaatgtt tgatgacaaa tattgtccca catttgtcta 519181 ttcaatatta gaccaaacca ttccgggagc tgtttatgca gatgatcaaa cctttcctaa 519241 atcgtttttt ataggaactg aatcaggcat ttattttatt gcgggagacc aagggaatcg 519301 ggattttcat gatttcattg caggatatta tgaagaacaa gtgaaatcat caaaacgatt 519361 taccttgttt tcttccagtg atacatggga tagcgtactg aaacccatac tgaaagatga 519421 cttaaaccaa atgagaagag ctgcattttc ttatcaacca aaatctttca aaaagacttt 519481 gcaactgcca aaggggcttg tattgaaaag aattgacgaa gacatcattt cacatagcac 519541 agcgtttaac agcgcgtatt atgaggagta ttggaattct gtctcacagt ttgcttcaaa 519601 aggttttgga tttgccgtat tacatggcaa tcacgtagta agtgagtgta cctctatatt 519661 tttagggcat aatcgagcgg aaatggatat ctatacactt gaagaatata gaggactggg 519721 gttagcttat tgcgtagcaa ataggtttat agcgttttgt atggaaaatg ggattgttcc 519781 tagctgggat tgtgatattt gcaacaattc gtccattgca ttagcagcta aactagggtt 519841 taagacggta acggaataca ctatttacta ctctggctaa ccttaatgaa agaaccttaa 519901 aaggagatac caaccgatgt tggtatcttt tttgttttag agttttttta cccttttagc 519961 agaaaaatgg gtgatgaaaa tcttattcat tttatttact tttaggtagg taaaacatac 520021 cccgccaact gtaaccactc cgcctagcag agagagcagt gtgggtatct cgccgatcca 520081 gagccaagat atgatcaagg ctaaagccgg tgtaacataa agtgaaaggg ttgcttctga 520141 agcaccgacg aatgaagtga catatgctag tgcgaagtaa ggaataaccg tcggcaataa 520201 tcctaagtaa acgatagaca aagttgcgct tattgaagcg ttcatcatct cttcgcctaa 520261 gcctggcaga aacacaagca taggtattgt tccgccccaa atggtgaatg taacgaatgg 520321 aataaaacca tattttttta tatagcgggc ttgaaaaacg aaataaatac tctccgaaaa 520381 tgctgccagc aggatgacca agataccgct cattgaatat gtaaagtctc ccgccccaaa 520441 tgcaatcaat aatacaccca ataaactgat catagagcca agccatttcg taaatccaaa 520501 atgctcttta taaaacaggc gggatagcat ggctgagaag atcggtgccg tagtaacgag 520561 taagcttgca actccggcac taactgtttt ttcaccgatg ttcagcaaaa tgtgatagaa 520621 tgcaaatcct aaaaacccta aaagaaaaat ggcaggaatg tctttcaagt cgggtaggcg 520681 catctgagtc aaaacagcaa aaagcaataa tgccatagag ccgattaaca aacgaaataa 520741 agcaaggtgt tctggcgtgt acccttcaag tcctgcgcga attcccggaa aagcagatgc 520801 ccataaacca atcatgagac tatgagatat cattatttga actgttttct ttcgcattcc 520861 tctcactcct ctttacaaaa accaaccagt tatttaatgt gtttctatac taataaagat 520921 ttgatgatat ggcttcaacc agttcaatag attttgaccc aaccaattta ttttaaggag 520981 accgattcta tgagctttcc agaagaaaaa aagatgaaaa agctccctaa gtacagacaa 521041 atcgttcatt ttattaaaga gaaaatagga aatggagagt ggccgattgg aagcaagatt 521101 ccaagccagc gcacgcttgc aaaagatttt caggtaaatc ggagcacagt gattacagcg 521161 ttagaggaat tgatggccga tgggctaata gaaggcacaa tggggaaagg cacagttgtt 521221 atcaacaaca catggacact gatggctaag aattctgctc ccgattggga tcaatatgtc 521281 acctctggca ttcagatgcc aagccgaaaa atcgttcaag agataaatca atcagaatca 521341 aatacagacc ttatacagct cagtaaaggt gaactttcag ctgagatttt tcctttggct 521401 gttatgaaag agatgatggg gaaggtatct caacacatgg aggcattcgg atatgaagaa 521461 ccaaaaggtt acttaccttt gagggaggca ttaagcaact atttaaaaac cattggaatc 521521 aacgtctcat cttcttccat tctgattgtc tcaggagcgt tgcaagcctt gcagctgata 521581 tcaatggggc tgttacaaag aggatcaacc gtttatcttg atcagccctc ctacctttat 521641 tcattacacg tatttcaatc agctggtatg aagctgactg gacttcctat ggataatgaa 521701 ggacttttgc ctgaaaatgt tcatttaaca agaggagagc ggggaagggc tatcttatat 521761 acaaatccat gttttcacaa tccgactggt attcttatgt ctaaaaagcg acgggaagaa 521821 atcctagcag taagtgagaa tacacagctt cctattattg aagatgacat ttatcgtgag 521881 ttatggatcg atgaaattcc gccatatcct attaaaacaa ttgataaaaa tggacacgta 521941 ctgtacatag gaagtttatc gaaaacatta agcccaggtt tgaggattgg atggatcgtc 522001 ggaccggaac cggtgattga acgtttatct gacattaaaa tgcaaacaga ttacggatcc 522061 agttcgctat cccagagagt agcggcagag tggtttactt ccggccacta ccagcagcat 522121 gtagaaaagg ttaggcagca attaaaggtg agaagagaat tggccttgag tgctttagaa 522181 actcatttga aagaagtggc gacatggaat atcccaaaag gagggttttt tgtctggata 522241 aaaatattgc cttccatatc aatgaaatta ctttatacta aagccttatc aaaagggatt 522301 ctgatcaatc tcggcagtat ctatgctcag gaaaaaggga attatattcg cttatcatat 522361 gcttatgcat ctcttgaaga ccttcaaaag gggatttatg agttgggttt aatgattaaa 522421 gaattggcaa gcaggtaact tttatatcct taaatggatg tttcactaaa aaagagatca 522481 agcctaatga tcgcttgatc tgataataac aagggttact agaatagacc aaatcatggt 522541 tcggtcttaa aataatcatg tctctgaacg aaaagtcttt ccgacttctc ttcctaaacc 522601 aaagtagtgt ctgaaattat agataagcgg gctccatttg gaagggttga tatggttttc 522661 gtccagaatg atactttcct cggcatgaaa atgtagtgcc tgcgtctcta caattgcgaa 522721 tgacgattca tattctggaa gccgaatgtg tttcacttcg gcttcgattt ggatagggca 522781 ttctttaatt cgtgttggtg atactgtttt tgattgtaaa ggcgttaacc ctgctgcctc 522841 gtatttttct tttttatatg taaatccgat ctgcttcttt aaaggcggta tactcttttt 522901 tccgctataa gatgaaattc tttcaacgtt ttcccataaa tccgggccag gcaagtttat 522961 gacacactct ttgtgtcttt ccaaattgtc gatggctttt cctcccagtc ctactccaag 523021 gattatataa tgtccaagag cccaagaaga agacatagga ctaatattag tggttccatc 523081 ctcattcaat gtggttagaa gaaatgtcga ggtaccataa tacatgatct tgggtttgat 523141 ttccttaaat cgacgagtgt cttgtttttt gatgtccaac gttttttcct ccttgtcacg 523201 cttacattta tattgtaaag gattaacatt tcaactatca tcgaaatatg aatgtaagga 523261 ggaaaatcat gaatcctaat attgcaaaaa tctcttcgtt gctatcagat ccctcgcgtt 523321 cttccattct tctcagtctg atggatggaa ggatacaccc tgcgggagag cttgcatatc 523381 tcgctaacat taaacctcaa actgcaagtt ttcacctgaa taaattgctt gaagcaaagc 523441 tgattagcgt agagaagcat gggagacatc ggtattacag attggctgac tcagatgctg 523501 caaatgtgat cgaacaattg cttcatattg cgcctaaagc aaaagtcaaa tctttaaaag 523561 agtcaaaaga gaaaaaggac ttgcatttcg cccggacctg ttatgatcat ttggcaggtt 523621 atgtgggcgt gcaaatggca cattcactag ttgagcaggg gatgttaaaa aaagttgatt 523681 taaactttga ggtgacttca gagggtgctt tattcttttc gaagttaggc atcaatgaag 523741 agcaacaacg gaataagagg agagcctttg cccgctgctg tttggattgg agtgaacggc 523801 agcatcatat tgcaggagca ttaggaaacg ccctattggt gcgcatgtta gaagaagaat 523861 ggatcgttcg tatgcctaaa acgagagcga ttaggattac acaaagcggg aaaatcgcgt 523921 ttgaaaagca cctaaacgtg aagatttagg attttgaagc ggaaacatca gatgatgagg 523981 cacgatatct aggaggagta agatttgttc taatcttact ccttcttctt attttgaagc 524041 agctcgattc cccattgcaa tagagatgcg gttccaactg tttatttgat taatgatcag 524101 aacaaggtca acatattgtt cctcatcata atgttcccgc acccgatgat atagctcatc 524161 aggaaccctt ttagatggaa tgagcgtgat gtgttcagat agttcgagag ccgctttctc 524221 ttcaggtgag taaaaatcac attcattcca agcatgtaaa cagtaaattc gctgttcagt 524281 ttctcccatt ttgcgggcat cggacgtatg catatctatg cagaaggcac agccgttcat 524341 ttgagagact ctgattttga ttagttctct cgtcgttcgg ttaattgagg attgtttcgt 524401 gtatttctcc atatccatca tgattttcat accttcaggt gcaatctcat agtaggacac 524461 tctttgactc ataaagcaag actcctttcc atagaatacc tagattgtat cccggtattg 524521 atcattttac caatgtgcgg tttgaatgac agctgtttca gcgtcttttg gaaagaagct 524581 tctttgaata aaaataaggg tagccagcaa tgatgagtgg agctgctaat gcaagcagta 524641 tccatgagcc tgattggctg tctctagtga ctctaatgaa tatataagta ccgatcagaa 524701 aatataataa agcacctaga aaccaataca tgttcattcc tctttttcct tgctttttgg 524761 ttgcgcattt ttgtctgtca tatggcttaa tcgatcaggg ttctgatttt ttaatacctt 524821 ttcggtccgg attccttttc tctttaatga taaaattgtg agatcaatcg atttcaatga 524881 tgatcattcc ttcaatgaat agtaagttcc ttatgatttt aaaggtaaat ttgaaaagat 524941 aaaacgtaca tagaggcaga acgttcatgt acgtttgggc aatgatcact tgttggaaac 525001 tctaatgttt ccctgcacct gatattgttg tgttccttct cttcctataa aatgattgga 525061 tacatgtatg tttgcacgtt gaaatatggg ttcgattttc atgaatctct attcggtgaa 525121 acaggtaaag gaagtggata aggtttgctt ataaggaatc cttttaaaga taaatattac 525181 tcacatgata ggcgggcatt aaacatgctt gcactcagag tgccgggcct ggcttttatt 525241 ctcatgatct atatagcctc tatcgtgctg caatttgttt ctgggggctg gtccatttta 525301 ttgctttatg cgtttaccat attaatcgcc atttttgctt tgcttcattg gcactcatat 525361 cgctgggtta agaaaagagt gattctgtat ttcgcggtac aaggtttgat cacctttgca 525421 cttgctaatc tcatgactgg cttctttata cttgtgatta tcggccttta tgcattttta 525481 attggacaaa ttataggaat ggcagacaga agaaggactt ttctcattct ttatctattg 525541 ctgctgctgg tcataaattc ggcgtatcac cttcataaag gtgaagtttt gcattttatt 525601 gttattgctg cgccgatcat gattgtcatc atcacttatg ccgcaacatt ttttgcccaa 525661 gtcgatgaaa aaataaaagc tcaattgact cttgaaaggc tggagctggc tcatcagcag 525721 gtagaacagc tgacgctgca gaacgaaaga cagcggatgg cccgagactt acacgatacg 525781 cttgctcaag gtcttgtcag tttaaatatg cagctggatg cgattcatgt tcatctcgcc 525841 aaaggcaaca cagagagagc gaaggaaatc atacaacaat cgatgaaaag agtgaaaagc 525901 acaatagctg atgcacgttc agctattgac gatctccgca gcaaatcaga agaaatcggt 525961 gttttaaaag aaagaattac ctcgctaatg gatcatttta tagagtcgac aggcatggct 526021 tgtttattag attacagatt gcatcaggtg ctggatgtgc gtacagctga aaactgttat 526081 tacatcattg gagaatgcat gacgaatgcg gcaaagcatg ctgaggcgaa aacaatctgg 526141 atatccattt gggatgatga aaagggaagg ctccatttaa cagttaagga taacggcaag 526201 ggatttgatg ttgaaaaagg aaagaaaaag agaggacatt atgggcttct tggcatacaa 526261 gaacgcgtca gggcaataaa tggccaattc aatatcaaga gtacaaaatt gaaaggaaca 526321 caaattgaga tcactgtacc aattcaggga gagatgcaag atgaataagg ttttaatcgt 526381 tgatgaccat cttgtcgtga gggaaggtct gaagctttta attgaaacga atgatcaata 526441 caccattata ggagaggcgg aaaatggaaa agtagcagtc cgtcttgcag atgaattaga 526501 accggatatc attctgatgg atttgtatat gccggagatg agcgggttag aggccattaa 526561 acaaataaaa gaaaaacacg atacccccat cattattttg actacatata atgaagatca 526621 cttaatgatc gaagggattg aattaggagc gaaaggatat ctgttaaaag atacgagttc 526681 agaaaccctt tttcacacaa tggatgcagc catcagagga aatgtgctat tgcagcctga 526741 tatccttaaa cgtctgcaag aaatccaatt tgagcggatg aaaaagcagc gcaatgagac 526801 gcagctgaca gaaaaggaag tcattgttct aaaagcaatt gctaaaggtc ttaaaagcaa 526861 agcgattgcc tttgatttgg gcgtctctga gcgaacagta aagtccagat taacgtccat 526921 ttacaataaa ttaggcgcga attcaagaac tgaggcagta acgattgcca tgcaaaaagg 526981 tattctgaca atagacaact aaactgcata tttgaaaatt gcccaaacgt acatgcccga 527041 atgtacgttt ttttcatttc attgtcaact acaatgagaa agaatgtgat caagcaatgt 527101 gttgaaagga gattatcatg tcaaaaatgt tatatacatt aggaggatgg gttgctcgca 527161 atcgcataaa agcaatatgt gcgtggatcg ttgtgttagt tgctgcgata ggccttgcag 527221 tgaccttgaa accaagtttt tctgaggata tgtccatacc tgacacacct tcggaaaaag 527281 cgatggatgt gattcaaaaa gaatttcctc atggtcctga taaagggagc atacgggtta 527341 ttttcggtgc tggtgatggg gagaaactta ctgggaagcc agcaaaaaaa gcaatagaag 527401 atacgttcaa agaaatcagt aaagatgatt ctgttgactc gattgcaagt ccttttgtga 527461 cagggacaat cgcgaaagat ggcacagttg cctatgctga tatccagtat aaatcatcag 527521 cagatgatat aaaggattac tctatcaaac acttaaaaga cagtttgaaa atggctgatg 527581 atgaaggatt gcaaactgag ctaagcggag atgtaccggg agcggagatg gagataggcg 527641 gtgtctctga aattgtcggc attatcttgg cttttgtcgt tttagccatt acattcggtt 527701 ctttattaat agcaggtttg ccgattttaa ctgcactgat tggtttaggt gtaagtattg 527761 gactggtttt gattgggaca caagtatttg atattgcttc tgtcagtctt tcattagccg 527821 gaatgattgg ccttgctgtt ggtattgatt atgctttatt tatttttacg aaacaccgcc 527881 agtttttagg cgaaggcata caaaagaatg aatcaattgc gagagccgtg ggaacagcgg 527941 gaagtgcagt ggtttttgcc ggacttactg ttatcgttgc actttgcgga ttaactgtcg 528001 ttaacattcc ttttatgtct gcgatggggc tgacagcagg gcttagtgta ctgatggctg 528061 ttttggcttc catcacactt gtgcctgcgg tcttatcgat tgcagggaag cggatgattc 528121 cgaaatcaaa caagaaaata gaaaaacaaa gcactgaaac aaatgtctgg ggacgctttg 528181 tcaccaaaaa tcctatcatg ctaagtgtat gcagcattct gattttgatc gtcattagta 528241 tcccatctat gcatttggaa ctgggcttgc ctgatgctgg gatgaaagct aaggataatc 528301 cggatcgccg ggcatatgac ttgcttgccg aaggctttgg agaaggattt aatggccaat 528361 taacaatcgt agcggatgcc acaaatgcta cagaaaataa ggcggaggct ttcgcagatg 528421 cagtgaaaga aataaagggc ttagaccatg tagcaagtgt cactcctgca atgcctaata 528481 aagaagggaa ctttgccatc attacggtcg ttcctgaaac aggtccaaat gatgtcacaa 528541 cgaaagattt ggtacatgat gtacgcagtt tatcagataa aaacggagta gatttgcttg 528601 ttactggatc aactgcagtg aatattgaca tttcagatcg cctgaatgat gcgataccgg 528661 tgtttgctgt acttattgtt ggctttgcgt ttgtattgct gaccatcgtt ttccgttcgc 528721 tgcttgtgcc gcttgttgct gttgcaggtt tcatgttgac gatgacagcc actcttggaa 528781 tctgtgtatt tgtcttgcaa gacgggaatc tcatcgactt tttcaaaata cctgaaaaag 528841 ggccgatact cgcgttcctg ccgattttat cgattgggat tctgttcggg ttagccatgg 528901 attatcaagt attccttgtc agcagaatgc gtgaagaata tgtaaaaaca aacaatccag 528961 tacaagccat tcaggctgga ttaaaacaca gtggtcctgt tgttacagca gccggcttga 529021 tcatgatctt cgtttttgca ggatttatct ttgcaggcga agcttctatt aaagccaatg 529081 ggctggctct ttcctttggt gtactctttg atgcctttat tgtaagaatg acactgattc 529141 caagtgtcat gaagctgatg gggaatgcag cctggtattt gccgaaatgg ttagacaaga 529201 ttattccgaa tgtggatata gaagggcatc aactgacaaa ggaaatacag ccggaaatag 529261 atcatgaaca aaagaaacaa atcagtgtgt aatagaaaaa gcagatcttt tatgatctgc 529321 tcttttgctt atggtagtat ttagaagatg aagtcggcag ttaaaaggag acgcttatgg 529381 cgccatcact cattttcgat atggatggaa ctttgtttca tattggcaga agctgcatca 529441 tactagcagg catcccagga gaagtgacat gattttttga ctttgcattc actacttgat 529501 gccaaggatc ttgagaatcc ttcttgaaaa taaaggattt tacaactgat catataagaa 529561 acctaaagaa acaagcacac aaaaccagct gcgggttttg tccaagaaaa atagagtcca 529621 taagagggac tctatttttt gaagtgcccg gctagaagca tattgcagga ctttatgaat 529681 gcaaatcact atcttataag cccttaccgt gaaatgcctg tttctgcatt gaaaaaacgc 529741 attacacgtt catttacgta agtgggttgt tccatcgata aaacatgtcc ggcattttta 529801 atgacttccg cctcaatatc tggaacgaat gaagaggctc ggtgcagggc tgagtgggga 529861 tcatagatga cttcatgttc accaagtaat aataggatag gaactcttgc tgaacgtaat 529921 tcctcatcgg taaaaacata cggaaatccg tcggcattag gatttggatt tcttgatcca 529981 tcctgccaca ttacccctgc cttaaactgc ttcacaaaaa tcgggtgcag cacattctga 530041 tcattcatca tccaatttaa gaatgtttca actccatttg acgctgtaag gccaagagcg 530101 tatttgtaga aatcgtgatg aaatggcaaa aacgtttctg ccggactcag tatagctgcg 530161 ctttttactc tctcaggcat acgtaaaagg aaattcatcg tatggagacc gccaagcgaa 530221 agtccgatca tgtgggactt ttcgatcccc agattgtcaa acacatcaag aagccaattg 530281 gcgtaatccg ttcttgtacc gcttacattc tcaggaatac tcttgttttt atcacctatg 530341 atatcaactg cataagttct gtatttactg ctccaatcgg cgatgttggg ataccacatc 530401 gtcgagctga ataatgctcc gtggagtaat acaagcggcg gggcatcctc tgggccgctt 530461 gcaatcacat gtgtttgacc aaaacgagta gatatataga atgatttaca acggaccggc 530521 caaagactaa ggctttcatt ataagtttga taatagcgga taccgttgtc acttaattcg 530581 ggaatactag atgaatggtt tgacatacaa atgcccctcc caattttgtt taaatgaatg 530641 tgccgtttcg tgatggggaa tctgattttg atataacaga ctttatttac aatataatac 530701 agttgttatt agacgtcaaa tccaagatga aaaggaaaaa aacgattgaa acagattatt 530761 gaaaatcaat ataacagaat attaacctcc tttgtggagc cgcttcatta aaaccgcaat 530821 ccaaatgcat gaatcacaaa aatcacaaca ggagggatca ggagggaagg cagcagattc 530881 agtgttttga acttcttgat tccaagaatg cttagacctg aactgaggat gagtatgcct 530941 cccacaattg tgatttcatt aataaggtct gtattgattg cgctctccat tacttgtgca 531001 aataaataga tggagccctg ccaggaaaat aatacaagtg cggcagccgc tattccaaaa 531061 ccaaaagttg aagcgagcac aatggaggtg atcccatcta acatcccgtt tgtcagaagg 531121 tatgtataat ctccatgcaa agcggcttca acagggccta atattgacag cgaacctata 531181 caaaataata agaccgcagt tgataagccc tctgctaaat tgcttttaga aaatttgttc 531241 accagcttgt tgaatcgtaa ttctaaattg atgatctggc ctagcaaacc tccaatggct 531301 aaactcacga tgaatagaat ggggtattta ctatcaggca aatgctgtgt aatggcgttg 531361 atccccagtg cgaccgcagc gaatcccatt gcctgcatca aaatatcctg gtattcatct 531421 ttaatgcctt ttttgaatat ccccccgatt atgcttcctg caatgatcat cactgtgtta 531481 aaaatcgttc caaacataag ctttctcctc caaaaatcat tcctgcataa aaaataaacc 531541 ctctagttag tagagagtca agggagatca aaacatattc atgagattat ttgatgggca 531601 gcaggatttc agtcacgtaa ttatctaggt tattcgtaat gccataatca atgagtgtga 531661 tttcgattga gtcccctgct acctcataat gatgttcttt catatatgcc agtaattttt 531721 tgtagtatgg ttcggcttct ggatgtgacc ctttaaacct aatttgcaga tattctcttg 531781 aaggaaagat gatttctgaa gaagtttttt cattttcatc ttcaagaatc ataaatatac 531841 tggaatattt gtcaaactgt tttgctttca catttgctgc agaaatggat aaaccaatct 531901 tgcctatgaa tatatcttcg tttacattca ggtgggttct caattcagct aacgaatgtt 531961 cgatatcatg gccgagaaca tattcatgct gcaaataggc cacacgcatt gcgggaagtt 532021 tgatttttga aatttgatgt aacggcatgt taacggcatc ttctatatgt gtgatgcgtc 532081 gggagatctt tcgttcaatg cgttccaatt ctttcttctt gcgatcaatt tcaacctgct 532141 ggctttttag taaatgaaga agagtgtttg tattttgaga gttataaaaa tcaagaagct 532201 tattgattgg caggcctagg gccctcaaat acttgatggt atccagccgc tcaaactgtt 532261 gggtagaata atatctatag ttcgtttgct catctttata ttccggtttc aaaaggccga 532321 tttcatcata ataccgaaga gcagagattt tcacattgaa taactttgac acttctccaa 532381 tcgaaaaaaa ttccttcatt ctaacaacct ttctgtccta tgattgatat acacacatta 532441 tatagtacgg cgagtactaa aggtaaagtt tgcagcataa agaaaaaact ccttctaaaa 532501 aggagctttt cattcttcga aataaggatt tacatggatg agcacttctt ctacatctga 532561 aaactgtctt ttgatttcat ttcgaatttc gcgggcaatg tcgtgtccct gcttaattgt 532621 caaatcatga tccaaagata aacggacatc aagcaattta tagtggccat gttctcgcgc 532681 gcggattcta tcaattcgtt ttacctgatc acattgaaaa ataacagctt tatattcctc 532741 tatcagctcg ggatcaacac tcttttccat gagcacatca acagacggcc tgattaattc 532801 cattgaaatc ttaaaaatga ggtaagcaac gattgcactg gcaatggcat cggcgtacaa 532861 cagataggac catccacggc tgtttccgat gatagccaac aggacgccga taaaagcggc 532921 aagagaggca acgatatcgc ctttatgatc gtacgcaatc gctataatcg ctttgctgtt 532981 ccattttttc ccttgcttta tagaataacg atataagatt tccttagcca cgtacgaaat 533041 cagagccgca aacaatgcgc tgtattgggg aacgcttggc cctttaacaa aggacagaat 533101 cgcttctatg aggatataaa cggatacgat cactaagata attcctacaa tcgcctcact 533161 aatgacttca gcttttccgt gaccaaaagg atggtcttga tcgggcggtt tattggaaat 533221 tccgatcact gccaagactg caatcgaagc aacgacatct gccgcggaat gtattccgtc 533281 tgcaaacacg gcttcactat cgcctaccag cccaaaaaag acctttcctg ccattaagat 533341 cagattggcg atcaatgcaa tcaaagcaac ttttctgctt atttgttctc tttcacttgc 533401 cattttttcc tcctataaaa ctgcacaaaa aaataggagt gctctatata cgctctccgt 533461 atcctttcct gtgtaatcac tttgtttatc ataccaattc aatttcgagt gggtctatag 533521 caacgttgtt tcctgtttac taataaataa ggtgacagaa aaaaagttgg agctatgcta 533581 aaaaggtcat acagcaaaca aatgagttct tatgtaacaa cagtgatgat tcgctattaa 533641 aatgctgccg tcagtgaaaa atttccacct aattttcaaa aacctattga catgagaaga 533701 tctgtatttt actattatct catattcaag atattttaat ttgagatatt tggtcggaaa 533761 gatcagcgat caagcgcaac tctaagtgtt caatcgttgt cagttctttt acacaatatt 533821 caatatgatt ttttataaca taatatctcg aattcgagat aaaagggagt gtagcgtaat 533881 ggctgaattt actcatttag tcaatgaaag acgatctgca agcaattttc tttcaggtca 533941 tccaatcaca aaagaagatc tcaatgagat gtttgaattg gttgcattgg caccatcggc 534001 ttttaatttg cagcatacaa aatatgtgac ggttcttgac caggacgtaa aggaaaagct 534061 gaagcaggcc gcaaacggac aatataaagt ggttagctct tctgcggttc tcttggtatt 534121 aggggataag caggcatatc aacaagcggc cgatatctat gaaggtttaa aggtattggg 534181 gatattaaat aagcaagagt atgaccacat ggtgcaagac accgtttcgt tttatgaaaa 534241 caggggagaa caatttaaga gagatgaggc gataaggaat gcttcacttt ctgcgatgat 534301 gtttatgctg agtgctaagg aaaaaggctg ggatacctgc ccgatgatcg gctttgatgc 534361 ggaagccgta aaacggattt tgaacataga cgaccaattt gaggttgtca tgatgattac 534421 gattggaaaa gaaaaaacag agagcagaag accgcgcggc taccggaagc ctgtgaatga 534481 gtttgttgag tatatgtaaa aggagcggat aaaaatggct aaaaaaacga tgggaattca 534541 tcatattaca gcgattgtcg gtcaccctca agagaacaca gatttttacg caggagtgct 534601 tgggcttcgt ttggtcaagc aaactgtcaa ttttgatgac ccaggtacgt atcatcttta 534661 ttttgggaat gaaggcggga agccgggaac aatcattacc ttctttccgt gggccggagc 534721 ccgccaaggc gtcattggag acggtcaagt tggcgtgact tcgtatgtcg tgccgaaagg 534781 ggctatggca ttttgggaaa agagactaga aaagttcaac gttccctaca ccaaaatcga 534841 gcgctttggg gaacaatatg tagaatttga tgatcctcat ggactgcact tagaaatcgt 534901 ggaaagagaa gaaggagagg ctaatacgtg gactttcgga gaagtaacgc ccgatgttgc 534961 cattaaaggt tttgggggtg caaccctatt atcagagcag cctgacaaaa ccgctgacct 535021 tttagaaaac atcatggggc tggagcgagt cggcaaagaa ggagacttcg ttcgttatcg 535081 ttccgccggt gatatcggaa atgtgattga ccttaagtta acgcctattg gccgcgggca 535141 aatgggggcc ggaacggtgc atcacatcgc ttggcgggct aacgatgatg aagatcagtt 535201 agattggcaa agatatattg cttcccacgg atatggtgta actcctgttc gggatagaaa 535261 ctactttaat gccatttact tcagggaaca cggggaaatc ctgtttgaaa tcgcaactga 535321 tcccccaggc tttgcacatg atgaaacaca ggaaacaatg ggcgaaaaac tgatgctgcc 535381 tgtgcaatat gaaccgcatc gcacacaaat tgaacaaggg ctgctgccgt ttgaagtaag 535441 agagttagat tgatttgaca cataaaaaat aaagaaacat atattcaatt gatgattgct 535501 ggatggtact gtcagcaaag aatcagataa aatcaaagat gaggagagat acaaatggaa 535561 gatgcaggac tgttgcttat tcgtataatg attggtgtgg tgtttttgtt ttatggcaca 535621 caaaaattat tcggctggtt tggcggatac gggattaaag gaaccggaca atggttcgaa 535681 tcaattgggg tgaaaccagg aaacgttgcg gccgctctat caggtcttgg ggagttagta 535741 agcggaattc tatttatttt aggcgtattc ctcccgcttg gagctgctat cataacaatc 535801 atcatgttag gtgctatcgt aaaagtccat ggagcgaaag gttttgcgaa tggcgccgga 535861 ggttttgaat ataacctggt gctcattgca gtttccatag gggttgcact catcggttca 535921 ggagcttacg ctttgcattt ttaatacgaa agtatgtaag aacagttgct gcttgtcagt 535981 aactgttctt ttattttcac attttcggca agcttgcagg tactctgcaa agcaaaaaag 536041 cggatatcat aaatataaat ctgtatagtg aatgatacgt attgatgagc ttggtcatga 536101 aaaacagacc tatttgaagg agtaaatgga tgaaagagat gacaggatta cattcattag 536161 tttctataga aaactttatc aaacagcaca aattcagttt tatttatata tcaaggcctg 536221 gctgtacagt atgtcacgca gttctgcccc agctcagaat agtattggat cagtttccaa 536281 acatcaaatt ggggcatatc aatgctgacg atgtagcaga ggtcgccggc agattttcag 536341 ttttcaccgt tcctgtgctt cttttgttca ttgatgggac tgagtttcta agagaagccc 536401 gttttgttca ttttgaacag cttgaacaaa agctgaaaag ggtttatcga ttatatgaag 536461 gcgaataaag gaataaggca aaaaaagaac tcaaatgagt tcttttttta ttcttcacta 536521 ggcgaagaag ggttatcaac ctgcccttga tcacttgtat cattatcaca acttgctgaa 536581 ataataattg aatgagaagg agagtaatct cctaatgtga aattcactcc gtaatttttg 536641 ctgttcgcag tatggctgtt ttgcaagttt tgtccgatat ctgtattggc gttttgtgtc 536701 attccattta tcgtgagatt tgagatgttg atttgagatc gcatgcttca aaaactcctt 536761 tcactcagaa gtagctgtca taaaggacgc tggcagtcta tttacttcta tgatattgcg 536821 tttttatatc attgcatcaa cataatggta aaaataatag cgagtgaatg atcatctttt 536881 gaagatgatc aacctatcag cagaaataaa gccgcctgat aaagaggcgg cagatcgtta 536941 tatgtcatct atgaatttga tgtatcgttt ttcgtttgcc tgaaggataa gatagtcgtt 537001 tttaatgatg agtaggagcc tatagcagcg tagccataaa accagcccat aaatacgcca 537061 gaaaagaggc tgtgtcgatg gcttatgaaa acagaaatga caaggcctgt tattaaggca 537121 actgacggta caaaagtttt ggggattttc aataatattt tgaggatttg ggttatcaat 537181 atgatgattg gaacagctat cacagcatcc caaaagttcg tgtgaataat tggaaaagcc 537241 atacggcacc tcatgaagtg tttatttctt aatttttacg ctaaaagctt ggaaagcagc 537301 tcttggatcg catatgttac attttgggct tgattggcgg agcttgtttg gcttaaagca 537361 ttggattcaa aaaccaaacc tgtattactc ccaccggaac cctctgttgt tttagacaca 537421 gagaacgggc tgatggaaac tgcaaatccg ttattaaaaa cgctgttccc ggatatcgaa 537481 tgaatataaa ctgggaattt catcattcat ctctcctctc tgttatgact gtttatacaa 537541 tatggtgtgt gagcagcagt tgcttaaaca aaacggcaaa aactttcagt aagagacaaa 537601 aacctgcaaa atgccacaag cgccttttgt taatgcagct ttttagggac gtttttttta 537661 ttttttttgc caacttcatc aaaaatattc tgattgccag actgggcttg tccgtcctta 537721 tttatgaaat cggggtgaat gagttttttc agatccctga ctgttaaagg cttggcgtca 537781 tcagttaatt ctattcctaa ttgcccgttt gcctctaatg tcgcaatttt gacatcttgt 537841 atagccgtaa cgccgtgaag ccttagctgc atttcaagct ggtcagctgt aagtctcatc 537901 ttctttaagt tttcgatatg aagctgtccg ttttcaatga cgatttttgc ttttccggtt 537961 aacatctttt caatggtgtt cgatttcatt tggatccatt ccataacgat gagtgtgctt 538021 gtgaaaattg ccgctgcaat taatgttttg aagaggctgt actcgatgat tggctgaacg 538081 ataatagttc cgatcgaaat catgacaacc gtttgagtcg acgtcatttg tgcgattgat 538141 ttccttcctg aaattctcag caaaatgacc ccggctacaa tgagaacaag agattcccaa 538201 gtgaaattca tgctaccacc tgaccaatga tgaattagat ttgtcatggg attggctttt 538261 cttccggcca atcgcaattt aatatatccg aaaggcagtc ggttcattct gtcctgaacc 538321 gaacaatatt tttggtatag atggatatat taagccaaac aatgatagca acaggagttt 538381 tttggccgaa acaatctggg aagcggggag cgccataaca tgattgaact tgaagttgtc 538441 attagaacgg ttgccagctt tggcttgctg ttaatcgcag aacgaatttt aggcaaacag 538501 acaatctctc aaatgacgat ttttgatttt attgcggcga tcacactagg ggcgattgct 538561 gccggattag cttacaatac ttcaataaaa ccgcacaata tggccatttc gtttagtatt 538621 tttgtgctaa ccatttttct aatttcgttt ctgtcgataa agaacaggaa gctgaggaaa 538681 ttttttgccg gagatccaac agtgctgatt caaaacggga agatacttga atcaaatatg 538741 aggaaaatgc gttacacact tgattattta aatcagcaat tacgggaaaa agaaatattt 538801 aatatcgaag aagttctttt tgccattctt gaaacgaatg gtcagctgac tgtgttaaga 538861 aaaccgcaat tccggcatgt gaccaaacag gatttaatga ttgcggtaaa ccaagaacaa 538921 aggcttccga tagaacttat tatggacgga gaaatcattg agaataattt aaagcagaat 538981 cgtttgacgg aatcctggct tttggaagaa ttgcgaaaaa gagacataaa ggtgaaagag 539041 accgtgtacg cagtgctgct gggtaatggg gatatttatg tggatcaata taaagaccat 539101 atatcagtcc ctatggataa ggaatgaagg aacaatcaat cttaaagccc cttattgaac 539161 gcaacggttt caacttgtct tgggtacgaa atatgcagaa gcccgtttaa cagctgaatc 539221 tgtaacaaat gagtttcagc ggcttcggga agctgaatga ttcgctcaat ttctccgtaa 539281 taccgttcac gcagcacttc catttcggct ggaaaaacag gcgtgatcgt tcctttgatc 539341 agcagctggg ttttagacag taaacggatc gttaattctt cctcatacac accgggcatt 539401 tccacaatga taaaattata ttcctcatct tgataaaagt cgtaaacaaa cgtagaagct 539461 tcggaatcaa aaaaatgttc cggggcttta tatttgagca catttgtcca aaagtcactt 539521 tgtttatatt cattcgtaat ctcaagccac tttcgaattt tttcgaaatc catatgagat 539581 tctccttaaa tttgatttga aatcggcgca gaagggtttc cgatttggtc ttggtcacta 539641 acgtctgaat caatatttcc agtgtttaaa agtgaagacg taggcgaaag atcccctaag 539701 gaaaagtttg ctccaaaata tttgctgttc gcagtatggc tgttgtgcac agtcggaccg 539761 acatctatat ttccgttttg cgtgacgccg ttgatcttaa tatttgcgat attaatttga 539821 tatggcatag acgaaacccc tttaatctaa aattggcggt ggtgcaatcg gaggagcatt 539881 aacgttggat gtatcagagt tgccgataga tgtctggtca tttacatcag gatcgtttaa 539941 gaagttttcc attacggatt ctgtaggtga tgtatcaccg aaagaagagt tggtcccttg 540001 agatttttga ttgttggtag ggctgttata agcagcttcg cctattgtaa ttgaaccatt 540061 gcccgaaata ctgttgatct tcaaataata taggttgatt actgtagacg gcatcccatc 540121 acacccttcc atctttctgt acagtacatt atgcgccgct gcacccaatt gttccttgca 540181 tttacgggca aaactctatc tggccccgga gtgatgctca attatcagtg aatgaaaagc 540241 cattgatata ggaatcaatg aattgattca gttattcgaa atgcatgaga ccttttaata 540301 aaggaagctg gcaaacagga tcagtttgaa ataattgaca atgaagctaa tgccatgaaa 540361 taatactcgt gagtaacatt actcgtgggt attatttttg gggtggtcct agttgaaaag 540421 taaaggagta gaaagccgaa aacgattact taaagctgcc gctaatgaat tttcggttcg 540481 gggattccat gacgcgaagg taagtgaaat tgtgaaaaaa gctgggttca cgcagccttc 540541 attttacctg tactttcaaa gcaaagaagc catctttgcc gagttaataa ccgattttca 540601 ctctcgagtc agaaagctga cagagtcact tcttctggaa aacggattaa acacggagga 540661 tgtgtcaaaa cgggtactgc tagctgtaga gactgttttt caatttttgg atgaggacaa 540721 ggatttaacc aagatcggct tttttctcaa cccggaagca aaacaaatga aaaaagactt 540781 ggcgatggtt ttgaaagaga acttagaagc agaacagcgg cttggctatt ttcactctga 540841 actggatatg gaaactgtcg ctgagtgttt ggtcggcatg attgaacatt taaccgaatc 540901 atttttgtta accggaatca aagatccggc aagcctcgca gcagaggttg tgaatctttt 540961 aatttacggg atgcttccga aagggaatga tgtaagatga tatctattat gatgaaagtc 541021 agtttggcag tttttatgct tgcgggaggc atcataaagg taagccgcgt tccctttcaa 541081 gttgagcatt ggcggcatta tcaatatcca ttatggtttc tgactgttac tggcattctt 541141 gaaatagccg gggcacttgc tatgacagcg ggaatttgga atcggtatgc agcaattgga 541201 gcaggtgttc tgtttgtcgt tctcatggcg ggagcaattc atgcgcatat gtttcgagca 541261 agacaatctg tcatcatggc gatacaagcg atgatttgtt tgattgtttc aatcatgatc 541321 atcatgggga gttacacgta agcttttcac taatgtttaa gaacaagccc atttgcagga 541381 aatctccttt tcttatcgaa taatagaaag tccaggaatt aactgaatca gtaaaataga 541441 gctccatttc tgtgttattc gtccggcatc agctgggctt tttttataaa ggaggaatac 541501 aggatggcat tcactttgga agacatgact gaggaagagt tcgaagcctt tcgcgggatg 541561 tccgtgcaaa attttgcgaa acaaaacata acgtcaggaa cttggacgga aaaagaggca 541621 tttgagaaat cggagcaggc atatgagaac atgattccga atgggcgaga cagcagcaat 541681 cattattttt ggaacatcac aaatgaccaa ggagaaagaa tgggctggct ctggctgtat 541741 gctgatccat tacatccgca aaaggaagcg tttatctatt cctttggatt gtatgaagcc 541801 tttcgcggaa aaggacttgc tcaattggcg cttcaaacgc ttgatgaaag agcaagagag 541861 cttggtgcgg aaaggctggc tctacatgta tttgcacaca acgagacagc cgtctatctt 541921 tatcagaaga tgggctatgc catgaccaat atacgtatgc ggaaacagct atgctgaaaa 541981 gccgcttacg ttacccaaat acaacatgcc tatctggaag cggtggcagg gtactataag 542041 tcatcattag aaagattaag gtcatgggag gcttgaacat ataaagaaaa aggacaacag 542101 ctgttgtcct tttcaatgcc gcttgaactt tctccctcag tcttttttgt cttgatgatc 542161 cagctctttt attcgtttcg taagctcatt gaaagcctga tcaagctcct tatacccttt 542221 atcatttggc gtcataaaac tgagctttcc cagcacttct tgtctttctg tctcaagctt 542281 taaccgaagc tcctcccgct catttctttc tgaaggaacg tcgtttaact gcttttcgat 542341 gccgttgttt gagatgacga gtttactgtt tgttgttttt tcgagaaagt atcggtcatg 542401 tgaaaccgcc agcaatgtgc cgctgtattg tgacagtgtt tcttccagct gttcgcgtga 542461 cggcaggtcg agatggtttg tcggctcatc taaaatcagc acgtcttttt cctccagaat 542521 atatgccatc agcttgatct ttacacgctc acccatactc atatgcttga tcggttcagt 542581 ccattgggcg gctgtaaaac ctaagtgcct catcagattt tgaacgtgcc cccttgcttt 542641 gaatgtttca ttctcaaata actcttccgg tgtttgttct aaaggcaaat caaacacctc 542701 ctgcgttaaa tagccgatgt ttgcggacgg cgacacccat acacttcctt ctgctgtttc 542761 ctgtcccaga atgatgttca gtaatgtcgt ttttccgctg ccattggggc ctatgatcgc 542821 aaccttttcg ccgtgctgaa ttgtaaagtt tgcgttttta aagagagtcc tttctccaaa 542881 cgcttttgtt acattctgaa cttctaaaaa acgttttcct gttttgtggg ttgtatcgat 542941 tgaaaagcgg actgtatatt ctggggtaac gggttccgcc tttgcttttt caagctcttt 543001 ttcaagccgc ttctgcttgg attttatctg ggcatccgta cgcttcgctt ttacccggtg 543061 atattcttta aacccttcct ttttcgtcga ttgagcatgg gctttttccg accaagaagc 543121 gagcccattc atttgtgctt caatccgttc aaccattttt tgctgctttt catattcacg 543181 ctgctgggtg agtcttttct tctcccggaa cttcatatac ccggagtaat tccctttgaa 543241 ttcaatcagc gtctgatcct caagcgacca tatttttgtt gcggcttcgt ctaaaaaata 543301 tcgatcgtga gaaacgagaa tcacagtgcc gttataatgt ttcagctgtt ggatgagaaa 543361 ttgcaagctt ttttcatcaa ggtggtttgt cggttcatct aacagcagca gatctgcatc 543421 ctctgatagt cctttcgcca gccgcgcttt cagtttttca ccgccgctta actgatgaaa 543481 atcacgaaga ggcacatgcc atttctccag taacttcttt tcggcaggtg tctgatccgc 543541 aaaggaatac gccgcggttt cctgttcaac caaagccagt tttatatcct tccgaaggat 543601 ttgaccctgt gcaggggcta agtcattgtg aatgaggtgc agcaacgtag atttcccagc 543661 gccgtttttg ccgataatcc caatgatatc tccttgctga acactggcgt ttacatgttt 543721 aaaaacagtt tgatccttta cttcatagct aacgtttgtt aatgttacga tctctttcat 543781 ccatatccct cgctttaaag ggagaataaa aaaatcctcc caaatgtgtt ggaaggatta 543841 gccgtgcctg tgcatgatca aataagctat tttttataaa tagcagtgtc gtatatatag 543901 aaaatgggca gactaatcct attttttgat ttgaaatatt gatttcaaac ggtaaaaata 543961 agattagtta atcattgtcc acccatcatc ccttcttgtt ttgattacaa acactatagc 544021 atacctttaa attcaaaagc aaaggtcatt ttcatcaaaa aaactcctgc tctcattttt 544081 gaggcaggag ttttgagtct tattgatgct tcgcttttct cactttataa atcacaatca 544141 gcaaaataaa ccaaaccggt gtgacaaata aggaaacacg agtatcctgt gccagtgcca 544201 gcacaaccag aacaaacgcc aggaacgcaa gaatcaggta atttgtaaac ggataaagcg 544261 gaagcttaaa cttgtttgtt ttcgctaatt caggtcttgt tttgcggtat ttcatatggc 544321 agatgaccgt aatcccccaa atgtagataa agcatacggt tgaaatactt gtgatcaggg 544381 tgaatacgcc ttctggcatg atgtagttta acgtaacacc gattaaaatc acgatagctg 544441 aaaagaataa agcatttcta ggcactttac gctgagtcag tttcgccatt gactcaggcg 544501 cattgtgatc tttcgccagg gaatagacca tacggcttgt actgaataca gcgctgttgc 544561 atgctgaagc agcggatgtc aacacaacaa agttgataat acttgcagcc ccgacgatgc 544621 caacagcgac aaatacttgt acgaatgggc tttcgctggg attgatgata tcccaaggat 544681 agatgctcat aatcacgaga agagccccga tataaaaaag cagcacacgg acaggaatat 544741 tgttgatcgc cttagggatt actttttcag ggttttctgt ttcaccggcc gtaagcccga 544801 caagctcaat gccgacaaaa gcaaacacaa ccatctggaa cgagaggata aacccgtgca 544861 tgccattcgg gaacaggcct ccgtggctcc agaggtttgt gaagctggac actcctgagc 544921 ttgtggaaaa gcctttgaaa atcatcacaa ggccaatgac gattaacgcc aaaatggcaa 544981 tgactttaat caaagcgaac caaaattcta attctccaaa aagcttgact gtcgccagat 545041 tcataatcag taaaataata agagcgatta agccaggcac ccattgcggc acacccggga 545101 gccaatattg agtgtagagc ccgactgctg tcagatcagc catcgcaatg gaaatccagc 545161 agaaccaata tgtccagccg gtgataaaag ctgccatatc gcctaggtag tcttgtacaa 545221 aatccacaaa agagtgatag ttcaagtttg ataacagcag ttcacccagc gatctcataa 545281 ttaaaaagca aatgatccct gtgatcatat aagcaaataa aatcgaaggt ccggcaaaat 545341 gaatcgattt gcccgagccg agaaataagc ctgtcccaat ggctccgccg atggcgatga 545401 gctggatatg cctgtttttc aagcctctct gcaacgtttg ctgatttata ttgtctttcg 545461 tcatgtcgtc tgtcacttta tgtgttcctc cattgaaaat tgtttattga gtcagcaatc 545521 tatttttaat gattattata acactaaaat ttctatcttt tttactaaaa aaggattgat 545581 gaaaagaatt ttaatgtgat ttggactatt tcccgaaaaa agcggctcca tttagggagc 545641 cgctttttta tgctttttca gtttttgtca taaacaggta gagcccgtaa tctgtcggtg 545701 cggatgcgta gcctgcctgc cgcagcattg ctgtgatatt gccgcggtgg tatgtcccgt 545761 gattgacaac gtggggaagc agttcggaaa cagttgtttt catgattccg cttgagggat 545821 tttgaatctg gagtggctta ttgagctgtt ctttttgctg taaaaatagt atatagcgct 545881 cggataacct cagaaaaagg tcttccattt cctctatttc tttagcctct gtctgttctt 545941 taagctgttc agctaaagcc aacgcatcgc tcaaggtttt gccggaaaac acttcaatcc 546001 agccgagatc agaaagataa acatgagaca atacatggga tattgacgga aacacgcttt 546061 gaatttcttg atggtatatc tcttttggaa gctcttttaa tcggttgaat atttgttgat 546121 tggcccagac gttatattca tacaatttga atgcaaaatc tgacatgtta aaattccccc 546181 tttcgtgtgt atagctttca ttatacacga acatgagttc ttatgtagag tgctcgaaaa 546241 taaaatttgt tgacatatat agtttagagg aataaactaa ttgacattga acataaagtt 546301 tagcggggta aactataatg cgtctgatta gagctcattt cataaattct tgttttttgc 546361 agcacacctg tcgactcaag aagcaggtta tccagcaggt cagtaattaa gtttccgtgg 546421 ttatacaccc acgacccgtt ccacggattg ccccctgcat caacaggaag ggaactttgc 546481 gctccaataa tataatgatg aggattagca tgtttaaccg cttcatcaag tggcgcttga 546541 tctgtacctt gactgccgac accttcaccg cctgattcat ctaataaagc attgattgtg 546601 ttttgaacca gttcaacgtg ggcaatctcc tctaaaaaaa tgccgcgaag cagatcgcgg 546661 tactgtttct gctttcctct gaaattagag ctttggaaaa aaactgcatc attgtacgca 546721 tttctccgta atgaccgcct aatatctcct gcaggacctt agcagctgcc gggtctggct 546781 tgtccggttt aatgatatta atcagttcct ctttgtagta atacataaca cgcctcattt 546841 cttcttaaga gattttctta tattatttgt aagatgagat aaaatatata catgataagc 546901 atgggaaggc gtgaaagaag aaaataaaaa aatacaggaa aagtgttgac caaataaaac 546961 aggcatggta tattattaaa cgtcgctgat gaacagcgtg aaacaaaaca gaaaaacaaa 547021 aaagttttcc taaggtgttt acaagatttt aaaaatgtgt ataataagaa aagtcgaatt 547081 gaaaaagatt cgaaaaaaca ttaaaaaact tcttgacttc aacatcaaat gatagtatga 547141 tagttaagtc gctcaataag cgcccgtagc tcaattggat agagcgtttg actacggatc 547201 aaaaggttag gggttcgact cctctcgggc gcgccatata agataccacg cgggtgtagt 547261 ttagtggtaa aacctcagcc ttccaagctg atgtcgtgag ttcgattctc atcacccgct 547321 ccattattga atgatctttg aaaactaaac aagacaaaac gtacctgtta attcagtttt 547381 tgaaaatcgc acagcgatgt gcgtagtcag tcaaactagg gcctgcacga tgcaggtcac 547441 acaggtgtca ccgcgggatg cggtggactt aacctgtgat ccatttatcg gagagtttga 547501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cgaacagatg 547561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 547621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 547681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 547741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 547801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 547861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 547921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 547981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 548041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 548101 gcccccggct caaccgggga gggtcattgg aaactgggaa acttgagtgc agaagaggag 548161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 548221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 548281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 548341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 548401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 548461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 548521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 548581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 548641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 548701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 548761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 548821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 548881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 548941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 549001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 549061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 549121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaattag taatacaaga 549181 tatcacatag tgattctttt taacggttaa gttagaaagg gcgcacggtg gatgccttgg 549241 cactaggagc cgatgaagga cgggacgaac accgatatgc ttcggggagc tgtaagcaag 549301 ctttgatccg gagatttccg aatggggaaa cccaccactc gtaatggagt ggtatccata 549361 tctgaattca taggatatga gaaggcagac ccggggaact gaaacatcta agtacccgga 549421 ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc gaaacgggat tagcccaaac 549481 caagaggctt gcctcttggg gttgtaggac actctgtacg gagttacaaa ggaacgaggt 549541 agatgaagag gtctggaaag gcccgccata ggaggtaaca gccctgtagt caaaacttcg 549601 ttctctcctg agtggatcct gagtacggcg gaacacgtga aattccgtcg gaatccggga 549661 ggaccatctc ccaaggctaa atactcccta gtgaccgata gtgaaccagt accgtgaggg 549721 aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc tgaaaccgtg tgcctacaag 549781 tagtcagagc ccgttaacgg gtgatggcgt gccttttgta gaatgaaccg gcgagttacg 549841 atcccgtgca aggttaagca gaagatgcgg agccgcagcg aaagcgagtc tgaatagggc 549901 gcatgagtac gtggtcgtag acccgaaacc aggtgatcta cccatgtcca gggtgaagtt 549961 caggtaacac tgaatggagg cccgaaccca cgcacgttga aaagtgcggg gatgaggtgt 550021 gggtaggggt gaaatgccaa tcgaacctgg agatagctgg ttctctccga aatagcttta 550081 gggctagcct caaggtaaga gtcttggagg tagagcactg attggactag gggcccctac 550141 cgggttaccg aattcagtca aactccgaat gccaatgact tatccttggg agtcagactg 550201 cgagtgataa gatccgtagt cgaaagggaa acagcccaga ccgccagcta aggtcccaaa 550261 gtatacgtta agtggaaaag gatgtggagt tgcttagaca accaggatgt tggcttagaa 550321 gcagccacca tttaaagagt gcgtaatagc tcactggtcg agtgactctg cgccgaaaat 550381 gtaccggggc taaacgtatc accgaagctg cggactgttc ttcgaacagt ggtaggagag 550441 cgttctaagg gctgtgaagc cagaccggaa ggactggtgg agcgcttaga agtgagaatg 550501 ccggtatgag tagcgaaaga ggggtgagaa tcccctccac cgaatgccta aggtttcctg 550561 aggaaggctc gtccgctcag ggttagtcgg gacctaagcc gaggccgaaa ggcgtaggcg 550621 atggacaaca ggttgatatt cctgtaccac ctcctcacca tttgagcaat ggggggacgc 550681 aggaggatag ggtaagcgcg gtattggata tccgcgtcca agcagttagg ctgggaaata 550741 ggcaaatccg tttcccataa ggctgagctg tgatggcgag cgaaatatag tagcgaagtt 550801 cctgattcca cactgccaag aaaagcctct agcgaggtga gaggtgcccg taccgcaaac 550861 cgacacaggt aggcgaggag agaatcctaa ggtgatcgag agaactctcg ttaaggaact 550921 cggcaaaatg accccgtaac ttcgggagaa ggggtgctct gttagggtgc aagcccgaga 550981 gagccgcagt gaataggccc aggcgactgt ttagcaaaaa cacaggtctc tgcgaagccg 551041 taaggcgaag tataggggct gacgcctgcc cggtgctgga aggttaagag gagcgcttag 551101 cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat aacggtccta 551161 aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca acgatctggg 551221 cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca ggttacccgc 551281 gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg ttggtacagc 551341 ttgtacagga taggtaggag ccttggaaac cggagcgcca gcttcggtgg aggcatcggt 551401 gggatactac cctggctgta ttgaccttct aacccgccgc ccttatcggg cggggagaca 551461 gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg aggcgcccaa 551521 aggttccctc agaatggttg gaaatcattc gcagagtgta aaggcacaag ggagcttgac 551581 tgcgagacct acaagtcgag cagggacgaa agtcgggctt agtgatccgg tggttccgca 551641 tggaagggcc atcgctcaac ggataaaagc taccccgggg ataacaggct tatctccccc 551701 aagagtccac atcgacgggg aggtttggca cctcgatgtc ggctcatcgc atcctggggc 551761 tgtagtcggt cccaagggtt gggctgttcg cccattaaag cggtacgcga gctgggttca 551821 gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg caggaaattt gagaggagct 551881 gtccttagta cgagaggacc gggatggacg caccgctggt gtaccagttg ttctgccaag 551941 ggcatcgctg ggtagctatg tgcggacggg ataagtgctg aaagcatcta agcatgaagc 552001 ccccctcaag atgagatttc ccattccgca aggaagtaag atccctgaaa gatgatcagg 552061 ttgataggtc tgaggtggaa gtgtggcgac acatggagct gacagatact aatcgatcga 552121 ggacttaacc atatttttga atgatgtcac acctgttatc tagttttgag agaacactct 552181 caatttgttt ggtggcgata gcgaagaggt cacacccgtt cccataccga acacggaagt 552241 taagctcttc agcgccgatg gtagtcgggg gtttccccct gtgagagtag gacgccgcca 552301 agcattactt ttatcatcgc ggggtggagc agttcggtag ctcgtcgggc tcataacccg 552361 aaggtcgcag gttcaaatcc tgcccccgca accaaatata tggttaaata aggagtgccc 552421 taagggtgca accaaaataa tcctatacaa atatggtccg gtagttcagt tggttagaat 552481 gcctgcctgt cacgcaggag gtcgcgggtt cgagtcccgt ccggaccgcc attaatgtaa 552541 acgaaacgat catgttttcg ttttttttgt gttttctttt actgtatctt ctgcttggtg 552601 tcatagccaa gctttcttta tatcgggaac atcttggata ttccagcaaa attcgataaa 552661 ctaggaagag cacaaatagg cataagcagg gttgaaagga ggttttggtt catggatgaa 552721 tttgatttga tacatagcat tactccgcgg accattcacc attcttccgt tgatgtagga 552781 ataggtgatg atgcagcgct ctacactgcg aaacacggcg ttcaggaaat tgtttgtgtt 552841 gatactatgg tagaagacgt gcacttcaaa ttacactatt cctcacctga agatatcggg 552901 tacaaggcgt tagccgttaa tataagtgat attgccgcga tgggaggcat tcctaagttt 552961 tatctggtat cacttgcggt accttcaaaa tggactgaat ctgaaatcaa ggcgatgtat 553021 gaaggaatga atgaactggc gaaactatat catatggatc tgattggcgg cgatacagtt 553081 tctaccgctg acaaattagt cgttacagtc actgtaatcg gtgaaattga aaagggacag 553141 gcctgtttgc gcagcttggc aaaaccgaat gatattgtgt ttgtaaccgg tgaaatcggt 553201 tcttctgcag cagggctttc tttattgctg gaagagacta atcctcaaaa ctcatctgtg 553261 gaaacggatt actttatcca caggcataaa cggcctgagc caagagtaag cgtcggcaga 553321 ttatgctcga tttttaaacg ggcagcttta aatgatgtta gtgacggatt ggctagtgaa 553381 ctgaacgaga ttgcagaagc cagctgtgtt tcaattgaaa ttgttgaaag catgcttcca 553441 attcattctg atttgcctaa gcttcatcct aactggaaag aatgggcttt gtttggcggt 553501 gaggattttg agctgacagg gacggtttca aatgaggagt gggaagtgtt gaagcaggag 553561 tgcgcagcgc ttcatcttcc cattacaaag attggctatg tcagggaaaa aacaaaatct 553621 aaagtgatcc taaaaacaga tcaaacatca atgatcttag agaaaaaggg atataatcat 553681 tttaaataag acgggtgact cgtgtgaagc aattaaaatg gagaactgta aatccagaag 553741 aaacaaaagc aattgccaag ctgacggcag cgtttgctaa accgggagac gtcctgacat 553801 tagagggcga tttaggtgca ggaaaaacga cttttacgaa aggttttgca gaagggctgg 553861 gaattacacg tattgtaaac agtccgactt ttacaattat aaaagaatat aacgatggcg 553921 tacttcctct ttatcacatg gatgtgtata gaatggaaga tgaaagtgaa gatttgggac 553981 ttgatgaata ttttcacgga caaggtgtct gtctcgttga atgggctcat ttaattgaag 554041 aacagctgcc acaggagcga ctgcaaattg tcatcaaaag agctggtgat gatgagcggg 554101 aaattacctt tactgctgtc gggaatcggt atgaaatgct ttgtgaggag ttaagtagac 554161 atgacaatat tagcaattga tacatcaaat tatacattgg gcattgcgct gcttcgagaa 554221 gacactgtta tagcagaata cattacatat ttgaaaaaga accactctgt aagagcgatg 554281 cctgctgttc attcattgct gaatgattgt gatatggcac cgcaggacct ttctaaaatt 554341 gtcgttgcaa aaggccctgg ttcatacaca ggagtaagaa taggtgtgac gttggccaaa 554401 acacttgcct ggtctttaga cattccaata agtgctgtat caagtcttga gacgcttgcg 554461 gcaaatggcc ggcattttga cggtctgatc agcccaatct ttgatgctag acggggacag 554521 gtgtacacag gtctgtatca atataaaaat gggcttttag agcaagttgt tccagatcaa 554581 aatgtgatgc tggcagattg gctggagatg ctaaaagaaa aggaccgccc tgttttgttt 554641 ttaggccatg atacttctct tcacaagcag atgatcgagg atgtgcttgg aacaaaagga 554701 ttcattggaa ctgccgccca gcataacccg cgcccttcag aattggcttt tctcgggaag 554761 gaaaaggaag cagctgatgt tcatgggctt gtcccggatt acttgcggct ggcagaagct 554821 gaagcgaaat ggattgaaag tcaaaagtag ggtgatagga tgaaaacaaa agcagcggtc 554881 agaaatatgc ggcttgaaga tatagatcac gtatacgaaa tcgaagcatc ctcctttacg 554941 tctccttgga cgaaggattc gttttatcat gagctgctgg aaaatccgta tgctcattat 555001 ctcgtgattg aaaaggacgg ccatcttgct gggtattgcg ggatttggat tgtgatggac 555061 gatgcccaga ttacaaatat agcgataaaa ccagagtatc gcggccagtc tttaggagaa 555121 acgctttttc gctcagctgt tgaactgtgc aaagaaaaag acgcaaggcg gctttcgctt 555181 gaagtgaggg tttcgaatca tcctgctcaa ggcttatata agaaattcgg gatgcagccc 555241 ggcggaataa gaaagaacta ttatactgat aacggggaag atgcgttaat tatgtgggtg 555301 acgataaatg agtgagcaaa aagacatgta cgtattagga attgaaacaa gctgtgatga 555361 gactgctgca gctattgtga aaaacgggaa agagatcatt tcaaacgtag tagcctctca 555421 aattgaaagc cataagcgct tcggaggcgt tgttccggaa attgcttcaa gacatcatgt 555481 tgaacaaatc actttggtta tagaagaggc gtttcgcaaa gctggcatga cgtatagtga 555541 tattgatgcg attgcagtaa cagaaggtcc gggactggtg ggagcgcttc ttatcggagt 555601 gaatgccgct aaagcattga gctttgcata taacattccg ttagtaggcg ttcatcatat 555661 agccggtcat atatacgcga accgtcttgt agaagacatc gtgttcccgg cactggcatt 555721 ggtcgtttca ggaggccata cagaactggt ttatatgaag gaacatggat catttgaagt 555781 cattggggaa acccttgatg atgcggcagg agaagcctac gacaaagtgg cgcggacgat 555841 gggattgcca tatccgggtg gaccgcaaat tgacaagcta gctgaaaaag ggaatgacaa 555901 tattccgctt cctcgcgcat ggcttgaaga aggctcttac aacttcagct ttagcggatt 555961 gaagtctgcg gtgatcaata cgcttcataa tgcatcccaa aaagggcaag agattgctcc 556021 ggaagatttg tctgccagtt tccaaaatag tgtgatcgat gtcttggtaa ccaaaacggc 556081 gcgcgcggca aaggaatatg atgtcaaaca ggtcctttta gccggaggag tagctgcaaa 556141 cagaggcctc agagctgcat tagaaaagga atttgcccag catgaaggga ttacgcttgt 556201 cattcctcca ttagctttat gcacggataa tgctgcgatg attgctgctg ctggtacaat 556261 tgcttttgaa aaaggaattc gcggtgcata tgatatgaat ggccagcccg gccttgaatt 556321 gacttcttat caaagtctca cgagataata gcgtgagact ttttatctgt ttgttattaa 556381 cagacaattc acaatttatc cacatatctg tgagtaatta tagagatatt gatggataaa 556441 gggctgaggt cactgttaat aaagtggata aattcagaat attttgtgga tagtgtgtat 556501 aaagcgctta ctttgtttat ttattagggg atgttctgtg gataaaaagc acctctaaaa 556561 agaggtgctt gactttttta atcttcttct gtggatagtt cttcccattc ggacaaaaga 556621 gattccagct cctgattaag cttctcattg tctgcatgga tagcttgtac tttttcatga 556681 tcctgataga cttcagggtc acatagcaat tcatcattgc ggctgatgtt ctcctcaatg 556741 gtttgaacgg tggtttcaat ttcttcaatc cgacggagtc gttggcgctc tttctttttc 556801 cattcttttt cttcctcgta ggaacgtttg gagtcagact tcactgtagc tggcgtttta 556861 tcagtttcct cttgctgatt cattttctcc aattcaagct gctctgtttt tttctctgta 556921 taataatcgt aatctcccag atactcctct atatggcttg aagaaagctc caatactctt 556981 gtggcgattc tgttaataaa atatctgtca tgtgagacaa ataacagtgt gcctggataa 557041 tcaatcagcg cgttttcgag aacttctttg ctgtctaaat ccagatggtt cgtcggttca 557101 tcaaggatga gaaagttggc tttttgaagc atcagcttag ctagagccaa tcttgctttt 557161 tcgcctccgc tcagtgaatg aactggtttc agcacatcat ctccggagaa taagaaattt 557221 ccgagacacg ttctgatttc tttttctggg agcccggggt actcgtccca cagctcatca 557281 aggacacgtt tagaggaagt caactcagcc tgttcctggt cataatagcc gacactgaca 557341 tttgagccgt aagaaattgt tccctgatct ggttttaggg tgtctattaa tgttttcagc 557401 aatgtcgatt tacctattcc gttagggccg acaagcgcag cgctttctcc tcttgtgagc 557461 atgaatgaca cttctgttaa aagcggcggc tggttttcat agctgattgt gagatcctga 557521 acacgaagga cttcatttcc gctctgtttt gtaatatcaa aatgaaagtt tgcggatttt 557581 tcatcgccaa gcggttttga catgacatcc attcgctcaa gctgctttct gcggctttgc 557641 gcccttttgg tggtagaggc tctcgccaga tttcgatcta cgaagtcctg cagctttgca 557701 atctcgtcct gctgcttttc atacattttc agatcttttt catactgcgc ggctttttgg 557761 tcgagataag cgctgtagtt gccgtgatac tttttgcttt ctgctcttga tacctcgtat 557821 acctggttta ctactttgtc caaaaagtag cggtcatgcg aaacgatgag aatggcgcct 557881 gaatagcctt gtaaataatg ctcaagccag gtaagcgtat caatatccag atggtttgtc 557941 ggctcatcaa gaatgagcaa atcaggctgt gttaatagaa gcttacctaa agccagtctt 558001 gttttctggc ctccgctgag gctttgaacc tgtgtagaat cgtcaaaatg gctgaagccg 558061 agaccatgca gcacagatct aacatccgct tcatattgat aaccgccttt atctttgaat 558121 tcctgctgaa gacggtcgta ggttttcatg atgctttcta attcacccgg gtcagctgcc 558181 gccatttttt cttccatagc ccgcatttcc ttttccattg cttttaagtg gtcaaaaaca 558241 gtcagcagct cttcttttat ggtaagctta gaatccaagc cagtatgctg ggcgagatat 558301 cccattgtaa tatctttcgg tttaataatt tcgccctttt catacgaaag ctggcctgcg 558361 ataattttaa ggagcgtgga ttttccggcg ccatttcttc ctacaatggc gatgcgatca 558421 cgatttctga cttccagctt tatattgttt aaaatagtat cagcaccaaa tgatttggac 558481 agctgattaa cttgtaagat catcatatta tttcacctct gctataataa gttaagtgta 558541 gcttatgaac cagaagtcag caaacaatac attggccata taagacatag agaagaaaat 558601 agtgtatgat ctgtttaagg agcgttttaa tatgaatgga ttttctcatt ttaatgaaca 558661 gggcagagcc cagatggtgg atattagcga aaaatcttcg actgtccgta ctgcggcggc 558721 tgtttcaagc gtacacatga agaatgaagt gtacgagaaa atacaaagtc acgatatcgg 558781 caaaggagat gtactggctg tcgcacaggt ggcaggcatt atggccgcaa agcaaacgtc 558841 gaatatcatt ccgatgtgcc atccgctttc attgagcggg gtagatatat cgtttgactg 558901 gaaaataaaa gaagcagaag ttatacttca tataaaagca caggtcaaaa cgaaagggag 558961 tacaggtgtg gaaatggaag cgctcacttc tgcatcggtg tgcgctctta ccgtttacga 559021 tatgtgcaag gcccttgata agggaatggt catcggccct actttcttgc tggagaagac 559081 aggcgggaaa aacggtgact ttaaaagaga actatccgag tataatttgg aggaccaaaa 559141 atgaataagg atcaatcaaa aattccgcag gcgacggcga aacggctgcc gctttactat 559201 cgctttttaa agaatctgca tgcgtcagga aaacagcgtg tatcatccgc tgaactcagt 559261 gatgccgtaa aggttgattc tgccacgatt cggagggatt tttcctattt tggagctctt 559321 ggcaaaaaag gatacggata taatgtggat tatttgctgt cttttttccg gaaaacgctt 559381 gatcaggatg agatgacaga cgtcatcttg attggtgtcg ggaacttggg aacggcattt 559441 cttcactata atttcacaaa aaacaataac acaaaaattt ctatggcttt tgatataaat 559501 gagagtaaaa taggaactga ggtaggcggc gtgcccgtct ataaccttga tgaccttgaa 559561 caacacgtaa aagatgaatc agttgccatt cttacagtgc cagcagttgc cgctcaatcc 559621 attacagaca gattggtcgc attaggaatc aagggaatcc ttaattttac gccggcccgt 559681 ttgaatgtgc cggaacacat tcgaattcat catatagatt tagcagttga gcttcagtca 559741 ctggtttatt ttttgaagca ttattcagtt ttagaggaaa tcgaatagag ggaaaggagg 559801 agcccaaata tgccgatcgg tcctggaagc cttgctgtta tcgcaatcgt tgctctgatt 559861 atcttcggtc ccaaaaagct gcctgaattg gggaaagcag cgggagacac acttcgtgaa 559921 tttaaaaacg ctactaaagg attaacgagt gatgaagagg aaaaaaagaa agaagatcag 559981 taagttagga tgacacgaat gaaagtgaat caaatgtcgc tgctggagca tattgctgag 560041 cttcgaaaac ggttgctgat tgtagcgctg gcgtttgtcg ttttctttat tgctggattt 560101 tttttagcaa agccgattat tgtgtatctg caagaaacag atgaagcgaa gcagcttacg 560161 cttaacgcgt ttaacctgac agacccgctt tatgtgttta tgcaatttgc gtttatcatc 560221 ggcatagtct tgacctcgcc ggttattctt tatcagcttt gggcttttgt gagcccgggc 560281 ctctatgaga aagagcgcaa agtaacgctc agctacattc cggtctctat tttgctgttt 560341 ttagcgggct tatctttttc atattatatt ttatttcctt ttgttgttga ttttatgaag 560401 cggatttctc aggacttgaa tgtcaatcag gtgatcggaa ttaatgaata ttttcatttt 560461 cttctgcagc tgacgattcc gtttggactg ctgttccaaa tgccggtcat cctcatgttt 560521 ttgacaaggc tcggaattgt gacaccgatg ttcttggcga aaatcagaaa gtatgcgtat 560581 tttacgctgc tggtgatcgc agccctgatt acaccgcctg agcttctgtc ccatatgatg 560641 gtcacagtcc cgcttttgat tttatatgaa atcagtatcc ttatatcgaa ggccgcttat 560701 cggaaagcac agaaaagcag tgctgccgat cgggacgtgt cttctgggca ataataaaaa 560761 atccatttct catgcgagaa atggattttc tttatttttg gttctttttg attttaaatg 560821 aaaaggcgaa catcttaaaa gaaatgctga tgttgtaagc ggcgaacacc atcagcagga 560881 tggagtaaaa tgaccacatg ctgcctggcg agcttgcggc aagataagta aagatgcacc 560941 ctacggcaaa gtagatcatt ccccaaacta ccgggtttct cataaaaata atcctccaat 561001 aatcaattgc atttgtgtgc tctgctgttc aaggtaatta cgaacaggct caagctgcat 561061 gatgacgacg aatgtattca tcattaaatg ggcgaaaatc ggcacccata tccgttttgt 561121 tctcgcatat aaaaaggcaa aggtaaagcc cattgctgta tatagaagga gatgcttcaa 561181 atcagcgtga acaataccga agataaccga gctgatcagt cctgcgaaaa agaaattcgt 561241 tttttcgtac agcgcgccga aaatgatttt tctgaagatg atttcttcta atataggccc 561301 gacgatggaa gaaacgataa tcatgagcgg gactgcctga atgacatcca gaatcgcttg 561361 tgtattttct gattctcttc cgatgccaaa aacataatat tcaatagagc ctgctattcc 561421 ttgagagaaa agggcaatga aaaaaccggc tatcgcccaa aggatagaaa gtccgattga 561481 gtccttctgt ccgtttcgca gcgtttcttt cggaacggtt ctcagaatga gcagaacaac 561541 aacgagacag gcgataaagc tgataacgga ccataatcct tgtgcatgca gcatattttc 561601 atctgtaggc tgtcctccgg cataaccgaa tttaaataac aagggaatcg cgattaatgc 561661 ggaaaactgc atgatgatat atgtcaaaat aataaaccaa tactgttttc tcaaatggta 561721 tgtactcctt tgttaagtgg gtttcgttca tctacagcta ttgtaacata atcggtacgg 561781 gggtgaaaaa gctaacggaa aagggagcgg aaaagaatga tgtaagcgtg aaaaattttt 561841 tatcttatca cttgaaattg gaagggagat tctttattat aagaattgtg ttagcactct 561901 ttagtgctga gtgctaaaat tacatattca tactattgag gaggttattt cattgttaaa 561961 gccattaggt gatcgcgttg tcattgaact cgtagaatct gaagaaaaaa ctgccagcgg 562021 aattgtgttg ccggattctg caaaagaaaa accgcaagaa ggcaaaatcg tggcagctgg 562081 ttcaggtcgc gtgttagaaa gcggagagcg cgttgcttta gaagtaaaag agggcgaccg 562141 cattatcttc tcaaaatacg caggtactga agtgaaatac gaaggtactg aatacttaat 562201 cttacgtgaa agcgacattt tagctgttat cggctaattc ttaaataaac aatacttaaa 562261 acatttgagg aggtcttgta aacatggcaa aagaaattaa gtttagtgaa gaagctcgcc 562321 gcgcaatgct tcgcggtgtc gatgcacttg ctgatgctgt taaagtaact ttaggaccaa 562381 aaggacgcaa cgtggttcta gagaaaaaat tcggttctcc gttaatcaca aatgacggtg 562441 taacaatcgc taaagaaatc gagctagaag acgcgtttga aaacatgggt gctaagcttg 562501 ttgctgaagt agccagcaaa acaaacgacg ttgccggtga cggtacaaca actgcaacag 562561 ttcttgcgca agcaatgatc cgtgaaggcc ttaaaaacgt aacagcaggc gctaaccctg 562621 taggcgtgcg taaagggatg gaacaagctg tagcggttgc gatcgaaaac ttaaaagaaa 562681 tttctaagcc aatcgaaggc aaagagtcta tcgctcaggt tgctgcgatc tctgctgctg 562741 atgaggaagt cggaagcctt atcgctgaag caatggagcg cgtaggaaac gacggcgtta 562801 tcacaatcga agagtctaaa ggcttcacaa ctgagcttga agttgttgaa ggtatgcaat 562861 tcgaccgcgg atatgcgtct ccttacatgg taactgactc tgataagatg gaagcggttc 562921 ttgacaatcc ttacatctta atcacagaca aaaaaatcac aaacattcaa gaaatccttc 562981 ctgtgcttga gcaggttgtt cagcaaggca aaccattgct tctgatcgct gaggatgttg 563041 aaggcgaagc acttgctaca cttgttgtga acaaacttcg cggcacattc aacgcagtgg 563101 ctgttaaagc tcctggtttc ggtgatcgcc gtaaagcaat gcttgaagac atcgctgtcc 563161 ttactggcgg agaagtcatc acagaagatc ttggccttga cctgaaatct actcaaatcg 563221 ctcaattggg acgcgcttct aaagttgtcg ttactaaaga aaacacaaca atcgttgaag 563281 gcgctggcga aacagacaaa atttctgccc gtgtgactca aatccgcgct caagtggaag 563341 aaacaacttc tgaattcgac agagaaaaat tacaagagcg tcttgctaaa cttgctggcg 563401 gcgtagctgt catcaaagtc ggcgctgcga ctgaaactga gctgaaagag cgtaaacttc 563461 gcatcgaaga cgccttgaac tcaactcgcg cagctgttga agaaggcatc gtatccggtg 563521 gtggtacagc gcttgtaaac gtatataaca aagtcgctgc agttgaagct gaaggcgatg 563581 ctcaaacagg tatcaacatc gtgcttcgcg cgcttgaaga gccaatccgt caaatcgcac 563641 acaacgctgg ccttgaagga tctgtcatcg ttgagcgcct caaaaacgaa gaaatcggcg 563701 taggcttcaa cgctgcaact ggcgaatggg taaacatgat cgaaaaaggt atcgttgacc 563761 caacaaaagt tacacgctca gctcttcaaa acgctgcgtc tgtagctgca atgttcttaa 563821 caacagaagc tgttgtcgct gacaagccag aagaaaacgg tggcggcgca ggaatgcctg 563881 atatgggcgg catgggcggt atgggtggaa tgatgtaata aagggatatt aacccttata 563941 catcaatgtt ttaaccgtct taaaaaacta gacaaagcgt gaataaaaaa agagaaggtc 564001 tttcatcagt ttactaaact gttgggagac cttttctcca tattagcggt catatgagca 564061 taaatgtcca tcgtcgtatt tatgtccgaa tgaccaaatt gttgctggat ttctttaatg 564121 cctactcctg cctcaattag taaggaggta tgggtatgcc taaaagagtg gggggtgaca 564181 ttctttttat cccagctttt ttgagcagcc gtttaagtct agtctcaata acctttctta 564241 attgcggatg accatcctcc cgctcaaaaa taaatgatga gtcttgataa atcaatctat 564301 ttttaagctt aatttcattt tgataaattt tatttttttt tagtagattg acatcgtttc 564361 atcaattcga acgatatcaa cagatcctgt tgttttaggt gttagcaatt ggtatttttc 564421 aatttgattg ttaggggtgt atagggtctt tgtgacctgg cttatcattg aaatctgtcc 564481 attttaaagc aagaagttca ccaattctta ggtcggtcta ggcaagtacg gtaaagacca 564541 aatggtccat ttctagcccg tcagattgag cgagctttag aaaatgtgtc agcacctctt 564601 tttccaatgc tttgttgctt cttgggtaat tgaaaatccc cagttgggtt cattttaata 564661 atcccttgag ttttagcttt tcggaaaatc atacggccgc aggcatgaat acctcccaaa 564721 caattgtgac tgtattgctc gttcagttct aacgtgcggt cttcatacat ttttttgtgt 564781 tttgctaatc gggtattgac ccaatactgc gataaaatgc atcattttct tttcactggc 564841 ccgtacactg cttattttta ccccactccg gttgtaaatc ttaagccaac cttttgcaaa 564901 tgttttgaag ggcatatctg actccttaat aaaagtcccg ttgtcgtttt ggagttctac 564961 gtgacgggct gctactgggg cttctttctt tgttttaaat cttcctttgg atatttctag 565021 acgttttttg gttaaagggt caatgcctag tagatatgat aactccacgt cttaccgcat 565081 tgcttgagtt ttgccattta tttgtcccta actaattttt tttcatcaaa ttggtcttta 565141 agtgagttta ataatttttg tttctctcga ctggtcaata attgcccttc atatttcaaa 565201 agattggata aatttgagat ggaatcaatc ctgatggatg gtaccgtaga ctttaataag 565261 aaacgaaagg ccaactgcga cttcagttgg cctttcctat ttataataaa gaaattgagt 565321 gagattgctg acagaactac gtactactcg ttttctttag ttgcccttgc taatcgttca 565381 acctctcccc gaatcccaat cgcaggctcc cacgaatcaa tcaaacgaat cgccttctga 565441 ttagattcca ccgctttcgt tttctctcct ttacgataca acagctgcgc cattccgtag 565501 tgatagtaga tcagttcaac ttgattggcg ttatgtttgt catagagcat ttgctcaaag 565561 gcttcttccg ctttttcaaa ctgatcacat ttcacgtaag cgacacccag attgaaatag 565621 gcttctatcg ttttttcgcc gccgtatgtg gagctgattt catttgccgc ttcgtataat 565681 tgaatggctt ctacatgata acctctcgca aagcttaagt caccgcgaac caatagaact 565741 ctgtgttgaa tggtagggga aatcggttga ttttcgattt cgtttaaaat tgtctctgct 565801 ttttcctgtt gcccgtcttt taaaaacagc cttgctttga gtgcatgtcc ccaaaccttt 565861 agatcatagg catcgtgagc gtctgattgt tcaagaatct tcagcccggc ttctatttgc 565921 tgaagcgctc cgtctaaatc attgacttcc atcaatgccc agcctgaggt gtcgattcgg 565981 aagtacgctt ctcgtgtgtg ttggcctaag tgatgggcgg cgtcggccgc tttgcgtccg 566041 tattcgattc gcaggggcag gttgattctg cttagaaaat ggctaatgcg ggtgatgagt 566101 tcgattagga tttctttttg ttcagtttca cttgcccatt ggatgacctt taagatgttt 566161 ggccattctt gtttcatttg atctaagttc cgtcccagca ggtagctcca atagatagag 566221 ttgggctgtt cccgctttaa atgggtttcg gcataatcaa tataatagtg cgcccagcga 566281 ttgcgggctt ctttttcata ttcgtgctgt tcggacaagt gctgttctcc gtaagcgaca 566341 acggtttggt gcgctaagta ttgtgtcctg ccttggcttc gttccggctg aatcagcgca 566401 tatgaccgca tttgttccat agcgtaatga aaacggcggg cgtctaatcc ggctgctgcc 566461 gccaggcttt tttcatcagg cggcttgctg aaaaagcaaa gcgtctgcca gagctttcgc 566521 gtatcttcat tgcatctatc ccaggtgcgg ccaaagagga attcaaacaa ttccagcagt 566581 gagtagcctg cttttccaag ctcatgaatc agctgctgag cggggatgtc atcgtctgac 566641 atataggcaa tgctgagtgc catggctttc gggtttccgg cagtcgctga aatgaattcg 566701 tttttcaggt cagatgatag atgtaacagc tgctccagct tttcccgttt acgtgggagg 566761 ttgcatgttt gtaagcagtg atgcacttct tgttgaaaaa attcgtgggc atctgtttgg 566821 tcaagaccgc ttagctgaat ggctgtcatt tctccgaagc tttcccgata agtttgcttt 566881 acgttttccc gcgctgtaag gagaactttt acgccttgcg gaaggctggt gataaattca 566941 tgaatgtcac gttctgcagt atcaatgctg tcaacgatca gcaggatcgg tttttctcta 567001 gtgtaattgg ctaacgcatt gcggacgaca aaccgtttta cattgattga tttatcgatt 567061 tgttctttgc gtccgagctg ataggcgatc gtatttaaaa aatcgctaaa gcttaatcct 567121 ttccaatcag cgctgaccca gatgatgctg ttgaatgccg gccaaactga agtatcgtcg 567181 acacaggaat aggcggcttc aagagcaatt gtggtttttc ccatgccggc ccagccggtg 567241 attaaacaga ctggtgatgg agaaagcatc cattgccgta tcgcttccat atcaaagctg 567301 cgtccgataa agcgtccgga ccagcgtgag ggtaaattat gcgtgatggg ctgttctgta 567361 agcgcattcg tttcttggcc gggtctgtca tgaaacagcc gttttactac attttcaatt 567421 tcgccttcac tcggagcccc gaataatccg tcttttcgca gtattttcgc ttttttcaaa 567481 caggatgctg cccatacagg caatgcgggt ttgatgactg ggatagtggt ggcttccagc 567541 aagtcggtca accactcgat atccaagtcg gtcttttcga gaatgatcca gatcattccg 567601 aacagttttc cgtcgtcgat tcttccggga atgtagtttg cccccatctg tccgatccag 567661 cttttgatcg tgtttgggga gactcccagc tggagtgcga ttttatctat gtaagactgt 567721 cctgtttttt cattcttttt ccttctgact ttataatcag gatgaagttt tagcgttttg 567781 acgccaggtg ccagcatttg tgcaaattgt tttcggtttt caagttcagc cataagcctg 567841 cacctcctat tagtactatt ttatcaatcc agcgtttttt gtatatgaaa aaataaaagt 567901 acagtgccgc tgtcctttta tacagcagga aaggctgttg aacgtgttaa aaagcagata 567961 aaatgggggc agtaacagag aaaacaaaaa tgtatgcact tacattttat tttctaaaga 568021 aaggaacttg ccaaatgact cacacagtac ctcaaaacat gaaagcggct gttatgcaca 568081 acacaagaga gatcaaaatt gaaacattgc ctgtgcctga tatcaatcat gatgaagtgt 568141 tgattaaggt gatggctgtc ggaatttgcg gatctgatct gcattactat acaaatggcc 568201 gaataggcaa ctatgttgtg gaaaaaccat ttatccttgg gcatgaatgt gcgggtgaaa 568261 ttgccgctgt cggatcatct gtcgatcaat tcaaggtggg agaccgcgtc gctgtagagc 568321 cgggtgttac gtgcggacgc tgtgaggcgt gcaaagaagg acgctataat ctttgcccgg 568381 atgtacagtt tttggctaca ccgccggtag acggtgcgtt tgtccaatat attaaaatgc 568441 gtcaggactt tgttttttta atcccagact cactttctta tgaagaagct gctttgatcg 568501 agccgttttc tgtcggtatc catgcggcgg ccagaacgaa gctacagccc ggatcaacga 568561 ttgcgattat ggggatgggc cctgttgggt taatggctgt tgccgcagct aaagcatttg 568621 gggcaggcac aatcattgtc accgacttag agccgctgcg gttagaagct gcgaaaaaaa 568681 tgggagcgac tcacattatt aatatacgtg aacaggatgc acttgaagag attaaaacga 568741 tcacgaatga tagaggcgtt gatgttgctt gggaaacagc agggaatcca gcggcattgc 568801 aatccgcact ggcttctgtg cgccggggcg gaaaattggc gattgtcggt ttgccttcac 568861 agaacgagat tccgctcaac gtgccgttta ttgcggataa tgagattgat atttacggga 568921 tcttccgtta tgccaatacg tatccaaagg gaatcgaatt tcttgcttca ggcattgtgg 568981 acacgaagca tctagtaacg gaccaatatt cgctggagca gacgcaagat gcgatggagc 569041 gggcgcttca atttaagaat gaatgtttaa aagtgatggt gtatccaaat cgctgagtga 569101 acagggagga tcttcgtatt ctccctcttg tttactggaa atgaaaacgg attcttgggg 569161 tgggaaatga tgattggaac agaaaaagta acggcattga aggcgaagca tcagtcaaaa 569221 tccagcaccg gcctgtcctg gtttgaacga atcggttatg gattcggcga tatgtcgtat 569281 aatattatct ttcagtttgt aaacgcatac ttattatttt attatacaga cgtcggcggc 569341 attcagcctg cggtaatcgc aactttgttt cttgttgtgc gtgtgctgga tgctattttt 569401 gacccgatca tgggattgat tttagataaa acgaatacaa ggtggggaaa agcaaggcca 569461 tatttgctgt gggtggcatt tccttttgcg ctattcacat tcttatgttt cacgacgcct 569521 catttcggtg agaccggaaa tatggtatat gcgtatgtca cttatattct gcttgggatg 569581 tcctttagta tgcaaacgat cccggtgaac agcttaacgg ggcggatgac gaattcggtg 569641 gaggaacgaa cggttctgac cacaacccgg atgattttgg tgtatatcgg cattctttta 569701 tccatttcct gtgcgacacc gcttgcaact gctatcggag gagaggatca ggcgtttgga 569761 tttcagatga cggcgctcat ctatgcggct gtcagcatcg ttttgaatct atttagtttc 569821 tttactgtac gggagcggat tcagcctaaa aagagaaaaa aacaagggat caaaaagacg 569881 ttatccgttt tattcaaaaa caaacccttg ctcatgttaa tttcatcatt tttggctttt 569941 gcgatcgggt ttaatattaa gctcagcacg atggtgtatt attttacgta taacgtaaac 570001 cataaagagt tcgtgtttat gggcaccgtt ttatttttcg gggcagcgct gatcagcaat 570061 ttgtttattc ctttcttttc tgagaagtgg ggcagaaaac aagtcatgat tatcacggca 570121 gctctatcgc ttatttctta tgccggcctg cattttacgc cgtattcttc aattccactc 570181 attttcattt ggcttttcgc ttcgggattt ttcacaacgc ctttaaatac gcttgcttgg 570241 ggaatggttg cggattgcgt cgattatgcg gaatggaaaa ccggaattcg cgcggatggt 570301 gttgtgattt cgagcatgag ctttattaat aagctgggtg ttgcgttagc cgggtcattt 570361 tcggccattt atttaggaat cgccgggtat gtggcgaata cagaccagac agttgcgtcg 570421 ttgaatgcga ttaaaaatat gaatgctttg attccgggat ttttcatttt gctttctatt 570481 attcttatcg ccttctatcc tttaacggaa aaaagatata aacacatcat ctctgagctg 570541 gagcaaaggt ctgcgagata aatagatgta aaatttttaa tattcaatgt tgtatttatg 570601 gcaaaaagta atatactgag actgtaatct agactttata aatgagtgtg ataatatgcg 570661 tagtcattct gtagtttgta ttggggaatt gttgattgat ttcttttgta ccgatgttga 570721 cgttgattta atggaagggc gccaattcct gaaaagtgcc ggcggggcac cggcgaatgt 570781 gtcggcagcg attgccaagc tgggcggaga cgccgctttc agcggaaaag taggaaagga 570841 tccgtttggg tattttctga agcgaacatt ggacgctgta catgtcgata cctctatgct 570901 ggtgatggat gagaaagcgc ctacaacgct tgcttttgtt tcattaaaac aaaatggaga 570961 gcgtgacttt gtttttaata gaggcgcgga cgctttgttt acgctggagg acattgacca 571021 ggaaaaacta aacgaagcga aaatccttca tttcggctct gcgacggcac tgttatcgga 571081 tccgttttgc tcagcctatt tacggttgat gtcgattgcg aaagacaatg gacagtttat 571141 ttcgtttgac cctaactacc gtgaagattt atggagggga agagtctcag agtttgtaag 571201 tgttgcgaaa aaagcgatcg ctgtaagtga ttttgtgaaa gtcagtgacg aggaacttga 571261 gattatcagc ggtgtgaagg atcatgaaaa gggagttgcg atccttcatg agatcggagc 571321 caacattgtc gctgtgacac ttgggaaaag cggaacgctt ctttccaatg gaaaagaccg 571381 tgaaatcatt ccaagcattc cggtgacatc aattgactca acaggggcgg gagatgcttt 571441 tgtcggtgcg gctttatatc aattggcaaa cacggatcag attcaatctg tagatgctga 571501 ttttgtgaaa ctgcgtgaga ttgtggcgtt tgccaataag gtcggagctc ttgtgtgcac 571561 taaaattgga gcgattgatg cactgccgag tttggatgag attggagttt ctttgtaaat 571621 cattgaagat gtttcttgaa agtctttgga cttttggggg catctttttt tattgcttac 571681 atttttgttc aggtaaaaag ttgtatattt tttgtttgaa atgtcatttt ttattaaaaa 571741 agtgaaactt ttaacgataa taaatagtat atgtaacaag ggttaccgaa ttagctttag 571801 gaggaacgat ataatgagta taattggaag atttaaagat attatgtctg cgaatatcaa 571861 tgctttattg gacaaggctg aaaatccgga gaaaatggta gatcaatatt taagaaatat 571921 gaatagcgat ttggctaagg ttaaggcaga aacagcagct gttatggctg aggagcagag 571981 agcaaaaaga gaatatcacg aatgccaggc ggatatggaa aagatggaaa gctatgcaat 572041 gaaggcgctg caagccggga atgagagcga tgcgagaaaa tttcttgaaa gaaaaacatc 572101 tttggagtca aagctttctg agctgcaggc ggcgaatcaa attgctgcaa ccaatgccgc 572161 acagatgaga aagatgcatg acaaattggt atctgacatt ggagagctgg aagcacgcaa 572221 aaatatgatc aaggcgaagt gggcagtagc gaaaacgcaa gaaagaatga acaaactggg 572281 cgcttctgtt tcaagtacaa gccaatcaat gtctgcattc ggccgaatgg aggacaaagt 572341 aaataaggca cttgatcagg ccaatgcaat ggctgaactg aacagcgctc cgcaggatga 572401 tatggctgat ctgtctgcaa agtatgacac tggcggttca agccaggttg atgatgaact 572461 tgcggcgtta aaagcgaaaa tgatgctcga taagtaatac ataggaggcc gcagctttcg 572521 gctgcggcgt cattttatca taaaatgtga gagggaacgg taatgataat atcttataag 572581 tgtccgaact gcggcagtga tatggcattt gacagtgaaa ccggctcgtt atcctgcagc 572641 agctgcggaa gacaggacaa tattgaaagc cttccgaaag aaaacattgc ggcacggttt 572701 tctgatgatg aagcaaaaga atatcaatgt aaaaactgcg gtgccgtttt gatcacggaa 572761 gctgaaacga cagcaacgac gtgcagcttc tgcggaggtg ctgcaatact tgccgatcgt 572821 ttatcaggac atttggcgcc ggcgaaggtc attccattta caatcagcaa gcaagaagcg 572881 gagcaggcat ttcgaaagtg gtgcaaaaaa ggccttctga caccaagagg tttcatgtct 572941 gctgatcgta tcaaaagcat caccggcatg tatattccat tttggatgtt tgatttaaat 573001 agtgaagtac aggtgagagc aaactgtacc agagtccatc aatatgaaga aggggattat 573061 atttgcacgg aaacagagca ctttgaagcg tttcgtgata tcaatctcga ttatttgaaa 573121 atccctgtcg atgcctctga aaaaatgaaa gacgaattaa tggacaaatt ggagccttat 573181 tcatacgaag agctgaagga ctttcaaacg gcatatttgg ccggttatat tgcggaaaag 573241 tacaattata ccgatgagga gctttttccg agggcaaaag agaaaatcag cagttatata 573301 gattcataca tccattctac tttttccgga tatacgtcag tcaatgtgag ggacaaacat 573361 attcacacga aaaacgtgaa cagcttttac gttttgcttc ctgtttggat ggtcagttac 573421 gattatgaaa gagcggagca tatctttgcg atgaacgggc aaacaggaaa ggtcgttgga 573481 aagccgccga tcagtcgagg aaaagtggct gcatggttta gcggaatagc aggcgggaca 573541 tttcttgcgt tgaagctcgt ctcattgatg atgggaggcg gattttgatg cgtggatttt 573601 ttgggaaagc gatctttgtt gtgctggctg ttttcatcat gatgccttta ctgggtatcg 573661 aagcggtaag agcctctgaa ttgcagcagc atgtgtacga tcgcgctcat ctattgtcaa 573721 aagcggagat cggaaaactt gaatctctct cggcaaagct gggtgcaaag agggacactg 573781 atttcatcat tattacgacc aaaagcacaa acggtgaaga tattgcagac tataccggcg 573841 atttttatga tcgttacgga aaaggcagta cagccattct gacgattgat atgacaaaca 573901 gagaagtgtt tatcgcaggc tttaaaaaag ccgaacagta tttggacaac agcaggctca 573961 atagcatcag aaatacgatt tcatctgatt tatccaatga aaattatttt gaagcttttg 574021 agacatatat tcagctttcc tataaagata tgggcataaa accgggagta aaccctgaca 574081 acatattctt tacatggtgg tttcagctga ttgctgccat cgcagtcggg ggaattgcgg 574141 tttcaatcat gctttatcat gcaggcggca aagtaacggt taatggaagt acatatatgg 574201 atcagcgtac gtctgatgtg attgatcaat acgacactta tattagaacg actgtaacaa 574261 gagaaagaaa accatcagat aaagacagcg gcagcgatgg cggtgttacg aaaggcggca 574321 cgtcatacag tgggagccgg ggcagttttt aaatgtaaga aatagagaaa gggagaggcg 574381 taatgtcgtt tttcagaaat caattagcga atgtagtaga gtgggaagaa tttagagatg 574441 atatgatttt ttataaatgg aacaatcgtg aaatcaaaaa agggagccgt ttaatcattc 574501 gtcccggaca ggatgctgtc tttttgaaca atgggcgggt tgaaggagtc tttcaagatg 574561 atggcgatta tgatattgaa tcagaaatta ttccattcct ttcaacgtta aagggcttta 574621 agtttggctt taacagcggc atgcgagctg aggtgctgtt tgtcaatacg aaggaattta 574681 ccgtaagatg gggaacaaaa caggcgataa atattccggc agcgggaatg ccaggcggga 574741 tgcccattcg cgcaaacggc acatttaatt tcaaggtgca ggactatatc agcctgattg 574801 ataaaatcgc tggcgtgaaa gatcaatatt ttgtagagga tattaaaacc cgtatcattt 574861 ctattctgga tcagcttctc atgaagtgga tcacaagaga agggaaagat atgtttaatc 574921 ttcaagcaaa cgcttttgat attgccaagg gaattcaaga ggacttagat atgcaattaa 574981 taagcgacgg gatgacggtc actggttttc aaatcatgag ctttaattat cctcaagagg 575041 ttcaagatat gattacaaag aacgcttcct acggtatggt tggggatgtg aacagatacc 575101 agcaaatatc aatgacggat ggaatggcat ccggaaagat gagcggaagc ggagcggctt 575161 cggatatggc tggaatgatg atgggaatga atatggccaa tcagatgatg aaccaaatga 575221 atcagaatca gcaggcacag tcatcaggcc cacagtcaac tggcagcgga agcaaaccga 575281 atttctgtcc aaactgcgga acaaaaacgg gcgaagccaa tttttgtccg aattgcggcc 575341 agaagcttgt ataagaatca tacagtgaaa agtccggagt gatcagcact cgggactttt 575401 ttatttagga gaataagcat tacctattgc ttgctcctga acaggccatt ttcgagcccc 575461 cgcttggata attcccagca gcaattgacg acgttccttt attgaattga cggcaatttg 575521 aaatgtttgc tttgataaag ccggtatgcc tgattgttga agctttgaga tgtctggttc 575581 tggcggcgct tgttctgcag gatggatata ggcagtatga acggtatcca gatagttttt 575641 gatacttgag cgcgcttctt tgatatgaag ctgattcggc tgatattgtt caggaattcc 575701 gtatttgaaa atggttagag cctcatccaa tacagcaaca gctataatgg atgattcctg 575761 atgctgcgtg ctgtggtaaa aatgaaggat ggggaaggcg ttatgctgag cggtcagctt 575821 tcccagttct gatgaggcag cgacaagaag aaaatcaatg tcgtgaaaat ctttgccatt 575881 ccatgcatta tggacgattt cagttccgtc atgccctaga cttaatacac tttgggcaaa 575941 ggagcgtttt tgattaaccg cactcaagac ggaaatcaaa tacgtgacag aaaatgtgat 576001 ggtaagcagt ccttgagctg tttcaataat cgtgacaagc ttccataggc ctccgttcgg 576061 agcgaggtcg ccatttccta atgtaaacat gacatagccg gaaaaataaa ttcggtctga 576121 ccaggaagcc ggttcttttg attgagtttc cataagtgag tgagggtcac tcgagtaaat 576181 caaaacccac ccgctccaaa atagactgat ccatatcact aacgtcaggc ataacagcag 576241 aggaccagcc atacttagaa cctttgcgtg gtcaccgctg attttgcggc agcccttcca 576301 cagccaggca gacaggcatc ttgtgatcgg gccggcaccg ctctctaacc ataacgtggt 576361 ccataaaaaa tcaatcatcc ccgctgtcaa taataaaagg cctgcaatga tataaccctc 576421 attcattttg gttgcctccc ttaagtcagc cttcttttat tttcttctct atttcctttt 576481 atcctgagtc tgaaacaatt gaacgaatgt ttgattttac agagaaaaat aggtgggagt 576541 tacccaacac ttactcattt ttcaatatga acagaaaatc acaagatttt tgacttgatt 576601 cacacatttt catgaagaaa aacgttcatt ttccccttga attggtgatt ttccttttat 576661 agagtaaaaa attttcagaa atttatattg actgaaagcg tttttataat tatgataata 576721 tcagatataa caaaaatgtc actataacat cactacaatt gaactattaa gtgactaata 576781 aataccaaat gaacgaggtt atgcacaaag aaatgaccat tgttctttta acgagaaatg 576841 aaatcgcttc catagggatt gacatgctaa gaagaaggga aggttatgag gttattggat 576901 aaaaacatga acaactattt tctgaagcct gcttacgaaa tgtgaggaag gcagcagccc 576961 tggaataagt ttttgacata cgcattttga aaaagactgg gggaaacagt atgaataaac 577021 aaggaaatca aatgtcattt ttacgtacaa ttattttagt ctccactttc ggcgggcttc 577081 tttttggcta tgataccggt gtgctcaatg gagctttgcc gtatatggga gagccggatc 577141 agcttaatct caatgccttc acagaaggcc ttgtcaccag ttcacttctt tttggagcgg 577201 cactgggtgc tgtgtttggc ggcaggatgt ctgattttaa cggccgccgc aaaaatattt 577261 tgttcctcgc tgttatattt tttatttcaa cgattgggtg tacgtttgca ccaaatgtta 577321 cggtcatgat tatttcccgt tttgtgctcg gtattgcggt tgggggtgca tccgtaacgg 577381 tgcctgccta tttagcagag atgtctcctg tggaaagcag gggacggatg gtgacgcaga 577441 acgaattgat gattgtatca ggacagcttt tggcctttgt ttttaatgcg atccttggaa 577501 caacaatggg agacaactcc catgtgtgga ggtttatgct ggtcattgcg tcacttccag 577561 ccttgttcct gtttttcggc atgatcagaa tgcccgagag tccccgttgg cttgtttcta 577621 aaggaagaaa agaagatgct ttgcgtgtat tgaaaaaaat cagggacgaa aaacgggcag 577681 cagctgagct gcaagaaatt gaattcgctt tcaaaaaaga agaccagctt gaaaaagcga 577741 catttaaaga tctttcagtc ccatgggtgc gccgtattgt gtttattgga ttagggattg 577801 cgattgtaca gcaaattaca ggtgtgaatt cgattatgta ttatgggact gaaattctaa 577861 gaaattccgg tttccaaacg gaagccgctt taatcggaaa tattgcgaat ggcgtgattt 577921 cggtattggc aacattcgtc ggaatctggc tgctgggaag agtggggcgc cggccgatgc 577981 tgatgacagg cttgatcggt acgacaacag cattattgct aatcgggata ttctcacttg 578041 tacttgaagg atcaccggca cttccgtatg tagtcctgtc attaacggtc acatttcttg 578101 cttttcagca gggcgccatt tcaccagtga cttggctgat gctatctgaa attttcccgc 578161 ttcgccttcg cggactggga atgggtgtta cggtattctg tctgtggatg gtgaattttg 578221 cagtcagttt cacgtttccg atattgctgg cagctatcgg gctgtccaca acgttcttta 578281 tcttcgttgg attaggaatt tgctctgtct tgtttgtgaa gaggtttttg ccggaaacga 578341 aagggctttc gcttgagcag ctggaggaaa acttccgcgc ttatgatcac agcggggcaa 578401 agaaggattc tggggctgaa gtgattggat aatttaaaaa agaatccgca cccgagtgcg 578461 gattcttttt ggtttcaaat tagttaggtc taacaaggat tttgacttgg cttttctctt 578521 taataagagc cccgaagcct tcctcgatca aatcatctag tacgattttt ttcgttacga 578581 gtttgtcggc tgagaaatag ccttctttca ttaatgacaa tacagccggg aagatgtcgc 578641 ggtatccgat aattcctttt actgtacgtt ctttgattac gatatcgttc ggatggattt 578701 cagcaccttt ttcccaaatg ctgacgatga cggtttcacc ggcaattgta gtggactgga 578761 tggcttgtcg taacaccact gggacaccag tgacttcgaa tgctacgtca acaccgcctc 578821 ctgtacgttc tgcaatctca gcgactacat cgtctgtttt agacggatca acgatgatcg 578881 cgccaagctc ctcagctttt tgctggcgtt caggagaaag ctcaacagcg taaatatcag 578941 ttgcaccggc agccttcagc gcttcaatga caagaagtcc gatcgggccg cagccgaata 579001 cagccgcttt gtcgcctgct ttgagtttgc ttgagcggac agcgtataga gcaactgcag 579061 aaggttcaac gagcgcgcct tgttcatatg ataattcatc aggaagtttg aacaaaagct 579121 cttcatccac agagacgtat tcagagaaac cgccgcctcc gccggctaag ccgaggaatc 579181 ccatttgttc atcaaggttg taggcgcctt ggtggccgtg tgtagcaaaa atcggctcga 579241 ctacaacgcg gtctccaact ttataatttt caacgccttc tccgacttcg acaacttcac 579301 cggagaattc atgccccatt gtgacaggtg ccgtttcatt tgttaatggg tgcggtttgt 579361 caaccggaat aaagatcggg ccgcccagat attcgtgtaa atcacttccg cagatgccgc 579421 accatttgac tttgatcttt acttttcccg gctccgtttt tggctcttcg atatgttcaa 579481 tacggatatc cttttggtta tgccatcttg ctgccttcat ggattaccac tcctataact 579541 tttgatgtga gtaattccgc accggtcaat atgaactgtt cacaaaatcg ccatttttaa 579601 aaccaaaaaa gaaatgaaat ttttatataa tataatctac gtttttttga aaaaaagaaa 579661 ctttaaagaa aaaagggtct cgcacactct tttttcttta tatgagagta tcaatcgttt 579721 acatagctat gaatttggtt tgaacaatac ggtaatggtt cgttcatatt gaatgcgaca 579781 actactctat caataattat aactctaata ctgctattat aataggataa tcttccatgg 579841 tttattttag cagaggtaac ttttttgact ttgtaacatt actgtaagga tattgaaata 579901 aaaaatagct ggttgatcgt gtataatctt cctagatgtt aacaaacagg gggacgaaat 579961 gttgaagaaa gtcattttag ccgcttttat cttagtagga agtactttgg gagcttttag 580021 tttttcatca gatgccagtg cgaaacatgt gaacggaaat attacttggt ataatggagt 580081 cgggaaaaaa ggctcttcag gtaagaaact tggacattgg gattgtgcga ccaaaatcgg 580141 atttgatgtt cctagaaacg ggacaaaaat cagagcttat gcaaaagcga agcctaaaaa 580201 ggtgattacg gtttataaaa atgatgttgg cagaatgcct aatgcagtgc tggatgttag 580261 ccctaaagcg tttaaagcgc ttggataccc attaagcaaa ggtaaagtag cggggcatta 580321 cagctattaa tgtacatata taatctggaa agcaagaagt cacattcttg ctttttctat 580381 tggtggagat aaaagatgaa aaaaagaatc atattattat tagcagtgat aatagcggca 580441 gctgccgcgg gggttgcgtt ttatgttgca aaggataaag gccatgagaa ggctgctgat 580501 gtttcagtca ataccgaaag cggtgatgag ctgctggttt caattacaga tacggatctg 580561 ctgacaaagt attatgaaaa tgacaaggtg atccatgagg agaagctgac cagctatccg 580621 gcatttgcct tggatcaaaa acagcaggtg ctctattata cgggcaataa tgaacagaat 580681 gaaatgaggc tttttaaatt ggatctgaag tctcataaaa aaacgatgct ttataaaggc 580741 gcggagagtg cggacagttt atttttatca aaggaccgtt caaccatcta tttccgctta 580801 ggaaaagcgg acgaaagcaa ttttcgaatc gccgcttttg atctgaagac gaaaaagtat 580861 aaaaatcttt atcctgccgc taatgatcag gatgacaccg tcagcagctt cttttataac 580921 caaaaaaacg attcatttgc attgcttcat tattctgtag aagaagacta caagaaaaca 580981 gatgaagcaa acgaaaaggg catcgaccct gaaccgacaa cgattcattt tgcggaaggc 581041 cgccaaaata aatttaatga gctgaaaagc ctgaaccaat ttatcagcga tattgctgtt 581101 tctgatgatg ataaacgtat tttattcaca tcatatacgc aaaaaggaac ggagcaaacc 581161 gcttctattc aaatgctcaa tgcggatacg aaaaaatatg aaagcatcat ctcaaatcaa 581221 aaatcattta agctgttaat tgacgcacag cctcagtttt ctaaggatgg gaagaacatt 581281 tattttcttg ccgaagccaa gggggctaaa aagctgaagg acgaaacagg gcgtgaagct 581341 aaggtgcgga cgatttattc ctatagcctt gagaataaga ccttcaaaaa agtatgggaa 581401 aatccgaacg gcatcatcaa cagctttttt gtgattaact aataaaaacc actcggcatg 581461 agctgagtgg cttttttaat ggatgaggtg cagggctaat gatccgagcc atttaaagat 581521 atgaatcaga ggtaccgaca aaaacagaag ttcaacatat gagttcattg caacattcag 581581 ctttttgaac gcagctcttt ttttcaagtc tttttgctgc tggtttgaga tcacgttatc 581641 actcctctta tatccatatt ataccattaa aacagacaaa aaagccctaa acgtttacag 581701 ttttgggctt ctttcttcgt atttggcctc ttgcaatgag aggcttttat tctgaaatat 581761 agaattttgt ctccgttcgg ggtttgtttg cttgcgggag actgcatttg ttatagggaa 581821 gaactagctt gttttcgttt ggctgttgtt ttggagattc actaatgaac ggatgccgtc 581881 gaccatttta cttccgcaca aagggcacaa tggcgtatca ctgctggcga agttttttcg 581941 ggtccagcca ttacagtctt cttttgtgca ttcccaagta ctcacatctt cctttggcag 582001 cggttcttga tttcgtttgt tatagtaaga cataaagtca cttcttccct catgtatttt 582061 actgcacatt tcctattgtc tcatactttt ccctaatctc ctaattcctt tttctttatg 582121 actttccaat aaccccatct aaaaaggaga ggagtgtgct gttaaaagca tctggctctt 582181 ctaaaaacgg gcaatggctg cttttaggaa aggtaacgag tgtcgcgttt ggaatattgc 582241 tgcgcaagtg ttccccagct gctgtagaga aaaatttctt gtcttccccg aagcacagca 582301 atgccggcac attgatgttt tggagggtgc cccggtaatc agcggccgtt tggttaaata 582361 aaatcgtgct agaaatggca gccggctgtt tgaggatttc tgccagcatc cattctgttt 582421 cggtctcggc aggcggttct gcgaacatat tctggatgaa gctttcgtag aaaggcagcg 582481 ggtcagtttg aatggcgtgc atcgctgttt ttaagccgtc aaaatcaaat ggaccatgtt 582541 cccagccctc ccattgatag tccgaagcgg attgatcgat gatcacagcg gcttgaatgt 582601 tatcattccc aaactgattg agataatccc atacgacaaa agcacccatt gaccagccgg 582661 caagaacgac atgatcaagc tccattgcat ttagaaattc ccttatgtca cgggcatatt 582721 gggaaatggt gtggccgtga agcactttgt cagattcgcc gtgtcctcta agatcaagac 582781 gaatacattg ataattggca gaaagcaccg aaaattgttt gtggaaaaat tgtccgctca 582841 tcagcacccc atgtataaac aggatcggcg tcccgctccc gtgtgtttca tagtaaaggc 582901 gtgtctgatc ttctaatatg atgtatggca tgtttctcct cctttagttt ccatcatgag 582961 tatggctggc tgctgttgag ctgatgatgg cagctgtcgc ggctgcctgc tgcgcttgaa 583021 tgactgtttc gatagcggtg tatagtcctg attccatcag cagatttttc tccatatgct 583081 cactgagata gaggctgaca gcaattttaa agttcatttc cttttgccat ttaaaagctt 583141 tttcctggtt taattcgtca gtgatgcaca aaacggtttt gatatctggc tcttccagaa 583201 atgtgaggag agcaaggtct ggataatgat aatcctttgt ttttttgaca gattcagtga 583261 tcgattgata tatctgtttg caagcggaaa caagcatttc gggctctttt tcactttgca 583321 aggccagaat atggctgacc tgatgtaagt actgtccttt tttaaagccg ttggctgcca 583381 gcagttgata gcatgtttcc gccttctgta gcgcctgcaa accttttccg ttttctccaa 583441 gcagtacggc aagcggaaca ttctgagttg aagtgaggaa ataatgattt ttcttcatct 583501 gctgataaac agctagcccc atgttcatct gttctttttg gtttgtcgtt tcagatttgc 583561 cggtgagcaa gatcagagcg gaaaggtatg tgaacatatc ccgcttatac cctagcttca 583621 ccatttcatt gtatacatcg atgaaagtct gaaatgtttg ttttgcctca tgctgaaaat 583681 gaatgtccag aatagatgca acagtaaagc ggtggtgtga attgagtgtt gagaagctgc 583741 cgatgtttga tttgatatag ctgctcaaat cataaaagcg ctgaaaatca aactctcttt 583801 tattcacaat atatgcagaa gaaatgagca ttaatatctg atcgtgtgaa actttccatt 583861 ttaattttgt ttttaattca gcataaatgg aaatgtaatg ctttgttttt tcatgtagat 583921 cgtgtgtgag cataaaaagc agctcctttt gttgttttta cgtaatacga taaatagggc 583981 caaaggtttc ataaagaaaa aacttgcctg ctagaggcaa gtttgtcggg ttatttatgg 584041 ggatcagtta tatccatcgg tctcatcatg tcatagtctt catgctctag aatatggcaa 584101 tgccatacgt atcgtccgct gtacggaccg aatgtcgccg cgattctcag gacttcacct 584161 gcatgcgctt gaatggtgtc tttccagccc ttttcacttg gcggcggcgg gacagccgga 584221 ccggtatagg acaattcccc gctttcttga taacgggcga tatcaaacgg ccgccggtct 584281 aatacacgga aggagactag atgcaggtgg atcggatgtg ttccgcgtgt cgggttgata 584341 atggaccata tttcagttgt gccgactttt ggtgtttctg tgacgggatc gtgccagcgt 584401 ttgttattaa gcagaaggac gggtctgccg tattcgtcct gggtgcctgc cagttttaac 584461 gttctgatgt tttgtattct ttcatgctgt accgaagggt atgaggcgag gtacttcggc 584521 tttctgcttt cgtctttttg tgccaatggt tttgtgactc tgaattgcat gatattcgca 584581 tctgtttcag gattgacgtc accgccgcag cccgcgctgt ttgccaaaat gatcgattct 584641 ccttcatatg ctgtgaagtc aatgatgata tcgtaacgtt cagcaggcgc aaggctgaaa 584701 gaattcagtt taacagatcg cggcaggagc cctccatctg aaccaatctg aataaaatct 584761 ccgccattat cgagtgacag gttataggtt cttgtattgg aggcgttgat gacacggaat 584821 cggtatttcc ttggctcgac ttccaagtat ggccatacct tcccgttgac gagtatggtt 584881 tctccgcaaa aagccggaac gattgaagga ttaggcagtg acggagaagg gttttccggt 584941 gcgctcggat aaaacaaaga accatcctca ttgatcgtgc ggtctgtgat aagaagcggc 585001 acatcgtatt cgtctgaagg cagttttaag cgtttttcct ttgggtcatg aatgatatat 585061 gcaccgacaa gtccggcata gacatttagc ctggtgagcg ccatggcgtg atcgtgatac 585121 cacaatatag ccccgcgctg ctggtttgga taatgataaa cctctctttt gaaataaggt 585181 cctgtttgtt caaagtcttt ggaaaaccaa gcctccggat acccgtcact atcatctggc 585241 gtgacgccgc cgtgtaaatg aacaacagtc tttacctcgg gctcttcatg ctggctgtca 585301 ctgtgatgaa tggtgtgatc aatcggaagg aaatgcgtgg aaggaaggtt attcatccat 585361 tttacatata cgttttcatt tcttttaacc tcaatggtcg gtcccggaaa taagccgttg 585421 tagccccaca ggcgggttgg agggagatcg cgatggagct gatgagtgca ttcctccatg 585481 gtgacttcgt agtatgtttt ttcttttgat tgctgtactg gctttagtgt atctgggatt 585541 gggagagcat ccacaaattt ttcaagtgtc attttcatct gtccttatct aaattttcca 585601 aattggtact atagttaatg acaataagga cgtgatggtt acaaaaaatc ttcgtgctgc 585661 agcccgcccg aagaagaaaa taacaaaatc ctaaacggca ggccgtttag gatttgatca 585721 gcattaaggc aggatatcgg gttgctgctg tgtgactggg ttggcagccg ctttctcgct 585781 caccttgcgt tttctgaaca caaggtaaga aatcagaacg attcccgtga tgacgcctgt 585841 cagcagcagc tcgtctctca tggaatcaat aaacgccatg gacactaaaa ttccgcaaat 585901 ggcgatgatg gtcaagtagg ttaggaaagg gaagagccac attttgatct tcaatgcttc 585961 tgggtttgtt ttttcgagtt ttttccgcat tttcagctgg gaaacggcga tgacaagata 586021 gacgagtaaa gcgattgcgc ctgatgagtt gactaagaat aaaaagacgg tatccggtga 586081 aaaatagttc attacgaccg cgatataaga gaaaaatgtc ccggccacaa tggcttgtac 586141 gggaacgcct tttttgctca atttcataaa acggcgcggc gcttcatttc tttctgcaag 586201 tgaatacagc attctggatg tggtatacaa acctgaattc aggcaagaga gtacggctgt 586261 gaggacgata aagttcataa tctgtgcggc tgcgggcact cctatatgct caagtacagc 586321 gacgaaaggg ctttctaaaa tatttgctga attccatggc aacagcgcca cgacaatggc 586381 gattgagccc acgtaaaaga cgatgatgcg ccatacaacg gatctggtgg cttttgtcac 586441 agattcgatc gggttggatg tttcccctgc tgcaatggca acgatttcag ttcccataaa 586501 agagaagatg acaacgacaa tgccgagcaa tacggagctg atgccctccg ggaaaaatcc 586561 gcctttgcct gtaagattcg aaaaaccgac tggctcactg cccggtgcaa agccaaaaat 586621 aaaggcaaaa ccaacgatta gaaaagcaat gatagtcaca actttaatga gggagaacca 586681 atattcaaac tcaccgaaag acttaacgga gtagacgttt gtcagggtga gcacaatggt 586741 caagatcaaa cttgtcagcc acagcggaat atcatggaac cagtattgaa taatgccagc 586801 accggcaatg gcttcgatcg ctatgacgat cacccagaaa aaccagtaca gccagccgat 586861 tgtaaatcct gcccacggtc cgatggcgtc gtgagcgtat tgagaaaacg atccgctcgt 586921 cgggtttacg gcagacatct caccgagcat tctcataata aaaatcacca ataatccggc 586981 taacgcgtaa gaaacaacgg cacccggacc ggtcgagtga atcactgaac cgctgcctac 587041 aaataggccg gctccgatta caccggcaat cgaaatcatt gtcatatggc gggtctttaa 587101 ttcctttttt aatcctgatt gagactggtt cataagttac ctccttttaa aatgcaatca 587161 ttactgaata ttatgataat tgaaactcta tcataaatat acagtttgtc gaaaattcgt 587221 gtaagaaaat ataccagctt atttcaaatt tgtagtgttt tgtttgcgct ttcagcgaat 587281 gtgtggaaaa aatgtttcgt tttttattcg ctgtgtgatt ttgcgtaata tttacaattc 587341 gatagaatgc gagaagcact ggtgtccttg ggtttgatgg gatttttggc ggagcaaata 587401 aattggatga gagaaaaagt gttccttcgt cactattttt ctgtggcggg tgaatcatgt 587461 ttctgtagac ccactgcgga tcagctttgt aagataataa taggaaaatg tgagcgagag 587521 gaggttttgt atggagagat atgatgaact gaaaaaggga gaatccggag cgctggtcag 587581 cattgccgcg tatctagttc tttccgcaat taaactgatc atcggttatc tttttcactc 587641 ggaagcactt acggcagacg ggttaaataa cacaactgac attattgctt ctgttgctgt 587701 gctgattggc ctgcgcatct ctcaaaagcc tcctgacgaa gatcatccat acggccactt 587761 tcgagcggaa acgattgcat cgcttatcgc atcgtttatt atgatggttg tcggactgca 587821 agtgctgttc agcgccggag aatctatttt ttctgctaaa caagagacgc cagatatgat 587881 tgcggcttgg acggcagcgg gcggggcagt cctgatgctg atcgtttacc ggtacaataa 587941 aaggctggcc aaaaaggtga agagccaggc gctccttgct gcggctgctg ataataaatc 588001 agacgcattc gtcagtatcg gcacatttat cggcattgtg gctgctcaat tccatcttgc 588061 ttggattgat acggtcactg cgtttgtgat cggtctgctt atttgcaaga ccgcatggga 588121 tatctttaaa gagtcatctc actctttgac agatggattc gacataaagg acatttccgc 588181 ttataaacag acaatcgaaa aaatctccgg tgtgagccgt ttaaaagaca taaaagcaag 588241 atacttgggc agtacggttc atgttgatgt ggtggttgag gtatcggcag atttaaatat 588301 tacggaaagc cacgatatag ccaatgaaat tgagcggaga atgaaggagg agcatgcgat 588361 tgattattcg catgttcata tggagccttt agaacaaaaa taatggagct tcctgtcaca 588421 ggaagcttca gcgtgtcgac aaaccctcgc attcgttgtc aggtctgcgc ttcggtgctc 588481 acgaattaga acattcgctc cgctcctatg ctcgtccttc ctagacttca agggttttca 588541 atcacgctga aaagatgaca aaaccctaaa atgaaagcca ttttaggatt ttgtcaacaa 588601 tctggagctt cctgccacag gaagcttttt tgtgtgtttt ggccagcttt attggtaaca 588661 atttgctaga atcgtttttt tatacagatt gctttttgtg gtaaagttag gttacattat 588721 gatgaatttt gtagatgact aggaggaaaa taatggcata tcaagaagac ctgcatcctt 588781 tgctggggaa agcagttgaa catattaata gagtaatggt tggaaaacga gacatcgcca 588841 tactcagctt agcagccctt cttgccaaag ggcatgtgct gcttgaggat gtacccggag 588901 tcggaaaaac gatgatggtc cgcgcgctgg caaagtcaat cggcgccgat ttcaaaagaa 588961 tccaattcac tccggatttg ctgccatctg atgtaacagg ggtatctatc tataatgcga 589021 aaacgatgga atttgaatat cgtcccggcc caattatggg aaatatcgtg ctggcagatg 589081 aaatcaaccg tacctctccg aagacacagt cggctttgct cgaagcgatg gaagagggga 589141 gcgtcacggt agatggccat acgatgcagc ttgccgatcc gttttttgtg atggcaacgc 589201 aaaacccggt cgaatatgaa gggacctatc ctttgccgga agctcagctt gaccgttttt 589261 tattcaaact tcggatgggt tatccgtcct ttaatgaaga gcttgacgtc ttatctcttc 589321 aggaaaaaag ccatccgatt gagacgcttg agccggttat tgcaaaagaa gacttcatct 589381 ttttacagag ggaagtgcaa aatgtccgtg ctgatgacag cattaaggaa tatatcgttg 589441 aaattgtgca gaaaacgaga cagcatcctt ctgttcaatt aggcgtcagt ccgcgcggct 589501 caatcgccct catgaaagcg gcacaggcat acgcgctgct gcatcatcgc gactatgtca 589561 taccggatga tattcaatat ttagctcctt tcacgctgcc gcaccggatg atgcttcatc 589621 ctgaggcaaa atttgaaggg attcaggcag aagcgatcgt aagggagatc atgtcagctg 589681 tgaaggtgcc ggttcaaagg tcggcggtcc gctgatgaat aagaaatggc aatggctcgt 589741 atatggttgg aagctgatta tattaacttt attgacggct gctgtttttt cttatgcgat 589801 gtttcagggc ggctttgtca gctggttttt gttttacgcg tttctccctt ttgtcttgta 589861 tgccgggctg ttggccttgt atccgctccg ttcttttcag gcttcaaggc aaatggataa 589921 aacacaattg catgcggggg acaggctggg cgtaacggtt acgctgagaa gaaagctgcc 589981 atttccgctg atgtatatgg tgattgaaga ttgcctgcca gaaggtatcg agtcattaaa 590041 tcgagacgga gccgcggcca aacggctcgt ttttccttgg tttaaacgga gcatgacgat 590101 gtcgtatgaa ttagctcggg taccgcgcgg agagcatcac tttcattctg tcagggtgcg 590161 aaccggggat gttcttggct tgattgaaaa aacagcattt tttgagctgg atgatacctt 590221 gtttgtttat ccattctatc agcgtttttc ctatcaggtg aatgagaggc atcaggaaga 590281 cggtgtaagc ggttcttctc ctattcatca gcaccattcc tcagtcgcag caagtgtgcg 590341 gaattatcag ccgggagacc ggtttgctgc gttagattgg aagacatctg cacggcggag 590401 ccagctgatg acgaaggaat ttgagccttc tcgcagcaaa aatctgtttc tgctgatgga 590461 ccgtttttcc tcagacgcat tcgaagaggt cgtttcagtg acagcttcga ttcttcattc 590521 tgttttaaaa aacggcgcgg gtgctggtct ggcttccatc gggaaggaaa aaaacatttt 590581 ccctattcag gaaggggatc agcattttaa gcacatgctt cggcatttag ccatcgctca 590641 ttgtgatgcg gcagacccga taagccgata tgcacgggaa gagctgggaa agccatctgt 590701 tcgccaagct gatcaagttg ttgtcacggg acagttaacg gaagatatgc tgcacctcgc 590761 agaaatagga ggcggccggg ttacggtgat actggcaaaa gagaaagatg ctgagctctc 590821 tcaagctgaa aatgtcatga ttgaacgcat gatgaaacgc caaatcagag ttcggatcat 590881 gaggggcggg cgagtttcgc gtgttgttta gaaagagagg tgactggttc acatgccgca 590941 cgatgatcac aagggaagcc gtttgagctt gctgttattt tattttctgg cttttttatt 591001 gctgtgggag tggcttaggc cgcttgacag ttttactgaa acgaaacata caggcttttt 591061 tagtgtcttt atcggcttga cgtttctgct gacttttttc aggatgaggt ggtttgtcac 591121 cgttcctttt tgtgtcatat ttacattgat ctcgatacac atcctgtttt atcaaggatc 591181 tatattcgac ttgagctggg tcagctcttt tttgcaggat gtctatctga atatcacgct 591241 gattcaatca gggcaatgga atgacatgat tccttcattt cggaccctgc tgttttttgt 591301 gctgctgtgg ctgctggtct atctcctgca ttattgggtg atttaccaga gaagaatttt 591361 gtttttcttt ttgatgacag tagcgtatat tacgattctt gataccttta cgccatatga 591421 tgccactttt gccgtaatcc gtatcgtgct gatcggcttc tttatgctgg gccttttata 591481 cttggaacgc attaagctga tggaaagaat cacactgcca aaaacatctg tcctgaaatg 591541 gtttcttcct ttatctgtat tggttttggc tgcaacggga ttcggactcg ccgctccaaa 591601 atcagagccg gcttggcctg atccggtgcc ttttcttaaa aaaatcactc atcaagaccg 591661 cgtgtctgca ggggaaagca aaatcggata cgggaatcat gatgaatcac tcggcggccc 591721 gttccagcag gatgctacac ctgtttttac atggcaggga aaagagcgta cgtatttccg 591781 tgtggaaacg aaggacacgt ataccggaaa aggctggatt gaaacagaca caggcatgtc 591841 gtatcagctt agcaatggaa aagttgaaaa tctgtggttt gaccataagg ttgcgacaga 591901 gcgccgcacc gtccgtgtaa aagtcgataa gcactacggg tataaccatc tgatgtatcc 591961 gattggtgcg gaaaccattc agccaaagca ggctgtctca cttgaaatga acggcaacac 592021 ggagcaaatt tctccgatca gtgaacaagc cggtgaaatc agaaatatgg ggaattatac 592081 agtaacgtac aattccccgg tctataagct ggatgaactg agaaaggtaa aagtgagaaa 592141 aaacagtgag gagtacacat tcagcgatcg ctacatgcag cttccagatt cactgccaga 592201 gcgggtgaga acccttgcga tcaaactgac tcaggatcac gacaatatgt ttgataaggt 592261 gaaagcggtt gaggactatt tagggtcaaa tgcgttcaca tatgaaacag aaaacgtgac 592321 cattccgaag aatgatgaag attatgtcga tcaatttctc tttgaaacga aaatgggtta 592381 ttgtgataac ttttcttccg ccatggtggt gctcttgcgc tcggccggca ttccggcccg 592441 ctgggtaaag ggttatacgt ccggcgaata caaagaagca gggaacaaaa atggcagcat 592501 ttacgaagtg acaaataaca atgcccattc ctgggtagag gtgtatttcc cggaacaggg 592561 ctgggttaca tttgagccga ctaaagggtt tacaaatccg gctcaattta catcttctga 592621 cacaaaagac tctggcagcg atagcagcag ctcgccgaag aaagcaaaag agaaacagaa 592681 agaagagaaa aaacagccgc aaaaagagga aaaacaaaag gaaaagcggg agccagctgt 592741 ttctaaaaag ccgtccgctt cgcatactaa tgccggtgcg ggcttgtatg cagcgcttgc 592801 ggttcttgca gtcctcctgg tggcagctgt attgctgtat gttttccgct cgttatggat 592861 tcctgttttc gccgtgagga aattgaagcg gcgcagtgat cagcacgcgt tttttgaggc 592921 atatggcgcg ctgctgaaac aactgaagag aaaaggactg ccgaaacgag acagtgaaac 592981 gctgcgtgat tatgcaaaac gaattgatga aaaatacgac atagaagaca tgtcaaagct 593041 gacattaagc tatgaaaggg cgctttacag aaatgaagat tcttcggcgc tatggaatga 593101 ttcgagagag ttatgggaaa atttaattaa aagaagatgg tcttgaccgc ttatcgacgt 593161 gttgttagaa ttagtgaata ttatcggagt ctgggagcga gttggcctga ctccggcaaa 593221 cggccttgcc aaagagggcg gagcgagctt catatctgtc ctcgtttttt tctgtgtcaa 593281 aaaacttaga ggagattagg tgacaaccat gacaaagtta gtgaatgaaa tgattcttgt 593341 ccttgatttc ggcagtcagt ataaccagct gattacacgc cgtatccgtg aattcggtgt 593401 ttacagcgag ctgcatccac atacattgac ggctgaagaa attaaaaaaa tgaatccaaa 593461 aggaattatt ttatccggcg gtccaaacag tgtgtatgat gaaaactctt tccgctgtga 593521 cgagaaaatc ttcgagcttg atattcctgt tttgggaatt tgctacggca tgcagctgat 593581 gactcattac cttggcggta aagttgaagc ggcaagccag cgtgaatacg gaaaagcaaa 593641 catccgcatc gaaggcacac ctgatttgtt cagagatctt ccgaatgaac aagtggtttg 593701 gatgagccac ggcgatttgg ttgtagaagt tcctgaaggc ttcactgttg acgcgacaag 593761 ccatcactgc ccgaactcag caatgagcaa agcggacaaa aaatggtatg gcgttcagtt 593821 ccacccggaa gtgcgccact ctgaatacgg caatgatctt ctgaaaaact ttgtattcgg 593881 tgtttgcgaa tgcgaaggcg aatggtcaat ggagaacttt atcgaaatcg aaatgcaaaa 593941 aatccgtgaa acggtcggag acaaacaggt tctttgcgcg ctaagcggcg gcgttgattc 594001 ctctgttgtt gctgttttga ttcataaagc gatcggcgac cagctgactt gtatctttgt 594061 agaccatggt cttctccgta aaggcgaagc tgagggtgtt atgaaaacat tcagcgaagg 594121 ctttaacatg aatgtgatta aagtagacgc aaaagatcga ttcttaaaca aactaaaagg 594181 cgtttctgat cctgagcaaa aacgcaaaat catcggtaat gaattcattt acgtgtttga 594241 tgatgaagcg gacaagctca aaggcatcga ctaccttgca caaggtacgc tttacacaga 594301 tatcatcgag agcggtacag caacggcgca aacgatcaaa tctcaccaca atgtcggcgg 594361 acttcctgaa gacatgcagt ttgagctgat cgagccgtta aatacgctct tcaaagacga 594421 agtgcgcgcg cttggcacag agctcggcat tccggatgaa atcgtatggc gtcagccgtt 594481 cccaggaccg ggactcggaa tccgcgttct tggcgaagta acagaagaaa aacttgaaat 594541 cgttcgtgaa tcagatgcaa tcttgcgtga agaaattgca aatcacggct tagagcgtga 594601 tatctggcaa tacttcactg ttcttcctga catccgcagc gttggtgtta tgggtgacgc 594661 aagaacatat gattacacaa tcggaatccg cgccgttaca tcaatcgacg gcatgacatc 594721 tgactgggcg cgtatcccgt gggatgtgct tgaagtcatt tcgacacgta tcgtaaacga 594781 agtgaagcac attaaccgcg tggtgtatga tattacaagt aagccgcctg cgacgattga 594841 gtgggaataa gaatcaatta atggaaacca tctttttggc aattttgccg ggaagatggt 594901 tttatttgtt tattacgaac aaaatccgat tttgcgcgac tattgttcgc tttttgtatt 594961 gttttttcaa aatgaacttg gtacaataga cacagaaatc aaataagatg aattcgtata 595021 atcgcgggaa tatggctcgc aagtctctac caagctaccg taaatggctt gactacgtaa 595081 acatttcttt cgtttgatat aaataaaaca cggttattta ttcaaactga aatccgtctg 595141 tagtcaagcg tcccaaaatg tattgggacg ttttttattt ggcgttttca ggacagaata 595201 aatagcaaag agtgaaggga gtcaaatagc ttgaaaacgt tttttcagtt tgatgagctg 595261 ggcaccagct atcgcaatga aatcattggc ggattaacga cttttttatc tatggcatat 595321 attttgttcg tcaatccgat tacgcttgct ttggagagcg tgaaagattt tccggaggcg 595381 ctgagaattg accagggtgc ggtctttacg gcgacagcgc tggcgtctgc agcaggctgt 595441 atcttaatgg gattaatagc gagatatccg attgccatcg cgccgggtat ggggctgaac 595501 gcgttttttg cgttttctgt tgtccttggt atgggtattt catggcaggc agctttgtcc 595561 ggtgttttta tttcaggtct tattttcgtt gctctttctt taacaggttt tcgtgaaaaa 595621 atcatcaacg ccattccgcc tgagctgaaa ttggcagtcg gtgcggggat cggcctgttt 595681 attacatttg ttggattaca aggttcagga atcattacag cgaatccttc tacgctcgtc 595741 acgatcggaa acattcacag cggtcctgtg ctgttaacga ttttcggtgt gattgtcacg 595801 gttattttaa tggtgcttcg cgtgaacgca ggcgtgttta tcgggatgct attaacagcg 595861 gtagccggca tgattttcgg tttggttccg gttccgactc aaattatcgg cagtgtgcca 595921 agccttgcgc cgactttcgg acaagcgtgg attcacctcc cggatatttt ctctgtacaa 595981 atgctgatcg ttattttaac attcttgttt gtcggatttt ttgatacagc tggtacactt 596041 gttgctgtgg caacacaagc tggtttaatg aaggaaaaca aattgccgcg tgcgggccgt 596101 gcgcttttag ctgattcatc ttctattgtg atcggtgccg tgcttggtac gtctacaaca 596161 acttcttacg tggaatcaag ctcaggtgtc gctgcgggtg cccggtcagg atttgccgca 596221 attgtaacag ggattctctt tttactggct acgtttttct cgccgctcct atcagtcgtt 596281 acgtcaaatg taacagcgcc ggcgcttatt attgttggtg cattgatggt ggcgccgctt 596341 ggcaaaatcg cttgggataa gttcgaagtg gccgttcctg ctttccttac catgatcatg 596401 atgccgttaa cgtacagcat cgcgactggt attgccatcg gatttatttt ctatccgatt 596461 acaatggtgt gcaaaggaaa agcaaaagag gttcatccaa tcatgtacgg gctgtttgtc 596521 gtatttatcc tgtactttat cttcttaaaa taaggaatga aaaaccagct gcactggcag 596581 ctggtttttt tgttgcaaaa gataaaacca tttcatacga tataccgtca tgtagatgtg 596641 ccgccatgct ttacttaaat ggaaatgact tgactgttca ggaaggcttc ggtaccttat 596701 ataagtgttt tattttcttg ctgaatggta ttccgccgta tttttttgat aggagttgct 596761 gacatgacgg aagaaagaaa agaaacgttt gaagaagaaa ttaaccagag tgaaagaata 596821 gatgcagatg aagaaccgct atcgagaatg tccagaaagg cgagccggca aagcaagcag 596881 aagcaaaaac aaaagcagaa accgcgccag gaacgcggtg aatcaactgt taaagacaag 596941 cttgcgtctg tttgggcagc catcaacaga tattgcggtt ttgcgttctc gattttaaaa 597001 tctccggcga aaactgtcgt aacggatggt ttttctcatt ataagtacgg tctgatttca 597061 atgcttatat tcagtatcat tttttcaatt gggaattggt ttcagttaaa ggcaagctgg 597121 aatcggccgc tcggtttcgg agaacgccat catgctttct atgacgggtt tttagttgtt 597181 cttgtgtatt tgctgatctt tttcgcggta atggtctttg ctatatgggc tgtctcccgc 597241 tatatgatga agcagaaggt gacgttcaga gaagcggctg ccgtattggg ttcattgctt 597301 gtacccgtaa ttgctgtttc aatcctttgg ctgatctttg cgatcgtaaa tatcccaatg 597361 ctgacagtac tgtttacggt gctgatcttg ttttccatct tttttatcat cgcgctgtat 597421 gtacagcgtg tgtaccaggc ggcacaagat gcaccaattg attatatcta ttgtgtattt 597481 gcagtagttg cgatagcgct gctgtttacg gcagtgactt ggccgtttat ttctgaatat 597541 attacggcgt cgttgattcc gctttaatga aaaaaccggc taatcctagc cggttttttt 597601 atgtcacact ttttacaaat atatctaaaa aacatagttg atttgtagga ttaacccgtg 597661 tatgatgggg aaaatgctga aaacgtccag cgcaaaaacc tttatgttta aggaggatga 597721 tggacatggc tgatgtactt cgccgagcaa ttaaccaaaa gaagcaattt ttaaaaacca 597781 aattactgct ctcggaattt tatcaaggaa gaggggaaca gcttgctgac tacacgctga 597841 gtgagcttga gaaagaatac aagtcccttc agaaaatgaa aaaagagatc tgacaataga 597901 tataaagagg tgagtctgct gaaaagcggg cttttttgtt ttgattttga aaaggcgaga 597961 aagagggtaa actactactg ttcaacacat aaaagcgtgt cgaaatattt tgcttaagct 598021 tacgggcgaa gctgattgta aacggctcat ttctctagta gaatatgaat gctttgtgca 598081 agctgaagag tagggggatg aataaaatga tgcaaaccat cttatcaaat gggatagcca 598141 tggttctcat aattctcatt attaatattg tctatgtgtc attttttacg ataagaatga 598201 ttttaacgct gaaaggacag cgttatttag cggccggcat cagtacgatt gaaatactgg 598261 tttatgtgac aggactgagt ctggtgctcg ataacttaga ccagattcaa aatgtgatcg 598321 cgtacgcgct cggttacggt cttggcgtaa ttgtcggcat gaaaatagaa gaaaaattgg 598381 cgcttggcta tattatggtc aatgtgatta cgaaggagct cgatcttgat cttccgaagc 598441 agctccgtga aaaaggctac ggcgtgacaa actgggtggc aggcgggctt gaaggcgacc 598501 gcacagccct tcagatcctg acgccgagaa gatatgaact ccagctatat gatacgatta 598561 aaacacttga ttcaaaagcc tttattattg cgtacgaacc aaaaacaatc cacggcggct 598621 tctgggtcaa agcggtgaag aagaggagaa ttaaagaata atggcaaagc cgaagaagaa 598681 aaagtttgaa gtgacagagc agcaaacgat tgatgcggtg cttcagcaaa tgaaagaaga 598741 aggatatctg cctgtaaggc gaatggaaga gcctattttt atggaaaaaa aggaaaatgg 598801 gtcaattcag atcgttccgt gcgggaaaaa aatcgtattt gaagggaaat tgatctaaaa 598861 cacgaacatt agtagaatga atttttgtat cgttcgataa tatcgttgac attatccatg 598921 tccgttgtta agataaacat gaaatcaaaa cacgacctca tataatcttg ggaatatggc 598981 ccataagttt ctacccggca accgtaaatt gccggactat gcaggaaagt gatcgataaa 599041 actgacatgg atatatcgca gaagcgaacg actgacgata catgtaccat gcccggtttg 599101 tattgcttcc tcataagtgc aatgcagagc gggtattttt tattttctga aaacaaaagc 599161 attagaaggt ggggaacaga atgcagccgc tagtaggaat catcatggga agcacttccg 599221 attgggagac aatgaaacac gcatgcgaca tacttgacga actcaatgtt ccgtacgaaa 599281 aaaaggtcgt ttccgctcac cggacgcctg atttcatgtt tgaatatgct gaaactgcta 599341 gagaaagagg catcaaggtg attattgccg gtgccggagg agcggcgcat ctgccaggga 599401 tgacggctgc gaaaacaaca ctgccagtca ttggagttcc ggttcagtcc aaggcgctga 599461 acggaatgga ttcacttctt tccatcgtcc aaatgcctgg aggcgtgcct gttgcgacaa 599521 catccatcgg caaagcgggt gctgtgaacg caggcctgtt agcggcgcaa attttgtcag 599581 catttgacga agaccttgcc cgtaagctgg atgagagaag agaaaataca aaacagacag 599641 tgttagaaag cagtgatcag cttgtctaaa caaatcatct atccgggagc tgtaatcggc 599701 attatcggcg gcggccagct tgggaaaatg atggctgtgt ccgccaaaca aatggggtat 599761 aaagtcgcgg tcgttgatcc ggtgaaagat tcgccgtgcg ggcaggttgc ggatgtcgaa 599821 attaccgctc attataatga ccgtgaagcg attcgaaaat tggctgaaat cagcgatatc 599881 atcacatatg agtttgaaaa catcgactat gatgcgctgc attggctaaa agatcatgcg 599941 tatctcccgc aaggaagtga gctgctgctt attacccaaa accgtgaaac agagaaaaaa 600001 gcaattcaat ccgcgggctg tgaagtcgca ccgtacagca tcgtcaaaac aaagaatgaa 600061 ttgaaacagg cagtacagga gctcaggctt ccggcagtgc tgaaaacatg ccgcggcggg 600121 tacgacggca aaggccaatt tgtgataaaa gaagaggcgc aaatggagca ggcagccgct 600181 ctgttagaac acggaacttg cattcttgaa agctgggttt cttttaaaat ggaactgtcg 600241 gtgatcgtcg ttagatcggt aaacggtgaa atttcaacat ttccgacagc tgaaaacatt 600301 caccacaaca atattctttt ccaaagcatc gtgcccgcac gggtagagaa agggattcag 600361 cagaaggctg ctgatctcgc agttaagctt gcagatgagc ttaaccttgt cggaccgctt 600421 gctgttgaga tgttcctgac agaggacgga gagcttttgg tcaatgaact ggcgccaaga 600481 ccgcacaatt cagggcatta tacgctggac ctttgcgaga cgagccagtt tgagcagcat 600541 atcagagcgg tatgcgggct tccgcttggg aagacagatt tgctgaagcc gggcatgatg 600601 gtgaatcttc tcggcgatga agtgaagctt gttgaggaag acccggagct tttaaaagag 600661 gcaaagctat atatatacgg aaaacatgaa atcaaaaaag gccgcaaaat ggggcatatt 600721 acatttatga agcagcctga agacgaatgg attcaggaga tcacaaataa atggatgaat 600781 agagacggag gacaagcaga atgatcgaac gttattcaag acctgaaatg tccgcgattt 600841 ggacggatga aaacagattt caagcatggt tagaggttga aattcttgcc tgtgaagcgt 600901 gggcggagct tggcgtcatt ccgaaagaag atgtaaaggt tatgcgcgaa aacgcgtcat 600961 ttgacatcaa ccgcatttta gaaatcgaaa aggacacgcg ccatgacgtt gtcgctttta 601021 cgcgcgctgt atccgaatca ctgggcgaag aaagaaaatg ggtgcattac ggcttaacgt 601081 caactgacgt tgttgatacg gctctttcct acttattaaa acaggcaaac gatattttgc 601141 tcaaggatct tgagagattt gttgacatta taaaagaaaa agcgaaagaa cataaataca 601201 cagtcatgat ggggcgcaca cacggcgtac acgctgagcc tacaacattc ggcttaaaac 601261 ttgcgctttg gcatgaagaa atgaaacgta atcttgagcg cttcaaacaa gcgaaagcag 601321 gcatcgaggt tggaaagatt tccggtgctg tcggcacata tgcgaacatt gatccatttg 601381 ttgaacaata tgtctgtgag aagctcggat tgaaagcagc accgatttcc actcaaaccc 601441 ttcagcgtga ccgccatgct gactatatgg caacacttgc tttgatcgcg acaagcatcg 601501 agaaattcgc tgtggaaatc cgcggactgc aaaagagtga aacacgtgaa gtagaggaat 601561 ttttcgcgaa agggcaaaag ggttcatctg caatgccgca taaacgaaat ccgattggct 601621 ctgaaaacat gacaggcatg gcgcgcgtga tccgcggcta catgatgaca gcttacgaaa 601681 atgttccatt atggcatgag cgcgatattt ctcattcttc agcagaacga attattcttc 601741 cggatgcgac aattgcgctg aactacatgc tgaaccgctt ctccaacatc gtgaagaact 601801 taacggtctt cccggaaaac atgaagcgca acatggaccg cactctcggc cttatctatt 601861 ctcagcgtgt gctccttgct ttgattgaca caggcctgac tcgtgaagaa gcctatgata 601921 cagttcagcc gaaagcaatg gaagcgtggg aaaaacaagt gccgttccgc gagcttgtgg 601981 aagcggaaga gaaaatcacg tcacgtcttt ctccagaaaa aattgctgac tgctttgatt 602041 acaattacca tctgaaaaat gttgatctga tctttgaacg tttaggttta gcatagaaga 602101 agcttttagc ggcttcttct aagccgccgc agtttgaaaa ttcccaacat tcgggttagg 602161 aggccttccg tgaatattgt gaagaatgaa cttttatacg aaggaaaagc aaaaaagatc 602221 tacaaaaccg atgacgaaaa cacgctgtat gtcgtgtata aagactccgc cactgccttt 602281 aacggcgaga aaaaagcaga aatcagcgga aaagggcgct taaataatga aatttcaagc 602341 ctcattttca aacaccttca tgctaagggc attaacaatc attttatcga gcgcatttcg 602401 gaaacggagc agctcattaa aaaggtaacg attgtgccgc ttgaagtcgt ggtaagaaat 602461 gttgtggcag gaagcatgtc caaacgtctc ggcattccag aaggcacgga gcttgagcag 602521 ccgattatcg agttttacta caaggatgac gcgctgggtg atccgctcat cacagaagat 602581 catatttggc ttttgaaggc ggcgactcct gagcaggtag aaaccattaa gtccattaca 602641 acaatagtaa atgaagagct tcaaagcatc ttcgacgatt gtcatgtcag attaatagat 602701 ttcaagcttg aattcggttt agatgcagaa gggcaagtgc ttttggcgga tgaaatatct 602761 cctgacacat gccgcttgtg ggataaagaa acgaacgaaa agctggacaa agatttattc 602821 agacgcaatc tgggaagctt aaccgacgca tacgaagaga ttttcaatag actgggaggc 602881 attcatcatg tataaagtaa aagtttatgt cagcttaaaa gaaagtgtac tagatccaca 602941 agggagcgct gtccagcatg ccttgcacag tatgacttac aacgaagttc aagatgtgcg 603001 catcgggaaa tacatggagc ttaccattga aaaatctgac cgtgatcttg acgtgctagt 603061 gaaagaaatg tgcgaaaaac ttcttgcgaa cacagtgatt gaagattata gatatgaggt 603121 tgaggaggta gtcgcacagt gaaatttgcg gtgattgtgt tacccggctc caactgtgat 603181 atcgatatgt atcatgctgt aaaggatgag ctcggccatg aagtggaata cgtctggcat 603241 gaggaaacaa gccttgacgg cttcgacggc gtgttaattc cgggaggatt ttcttacggc 603301 gattacttaa gatgcggcgc catcgcccga tttgcgaata ttatgccagc tgtcaaacaa 603361 gcagcggctg aaggaaaacc tgttcttggc gtctgtaacg gattccagat tttacaggag 603421 cttgggctgc tgccaggcgc aatgagacgc aacaaagatc tgaagttcat ttgccgtccg 603481 gttgaattga ttgttcagaa cgacgaaacc ttattcacag cttcctacga aaagggagaa 603541 tcgattacaa tcccggttgc ccatggtgaa gggaatttct actgtgatga cgagacgctt 603601 gctacattaa aggaaaacaa tcaaattgct ttcacatacg gctctaatat taatggaagt 603661 gtcagcgaca ttgccggtgt cgtgaatgag aaaggcaatg tattaggcat gatgcctcac 603721 cctgagcgcg cggtcgatga actgcttgga agcgccgacg gtcttaaatt gttccagtct 603781 atcgtgaaaa attggaggga aactcatgtc actactgctt gaaccaagta aagaacaaat 603841 aaaagaagag aaactgtatc agcaaatggg tgtcagtgat gatgagtttg cattgataga 603901 atccattctt ggaagattgc cgaactacac agaaatcgga attttttctg tcatgtggtc 603961 tgagcattgc agctataaaa actcaaagcc gattctgcgt aaattcccga caagcggcga 604021 gcgtgtgctg caggggccgg gggaaggcgc cggaatcgtt gatatcggtg ataaccaagc 604081 ggttgtgttc aaaattgaat cacataacca cccatcagct ctcgagcctt accaaggcgc 604141 tgcgactggc gtaggcggaa ttatccgtga tgtattctca atgggtgcac gcccaatcgc 604201 tgtattgaac tctcttcgat ttggtgaact gacttcaccc cgcgtgaagt acttgtttga 604261 agaagtagta gcgggtatcg ccggatacgg caactgtatc ggcatcccga cagtcggcgg 604321 agaagtgcag tttgacagca gctatgaagg aaatccgctc gtcaacgcaa tgtgcgtcgg 604381 tttaatcaac catgaagaca tcaaaaaagg ccaggcaaag ggtgtcggca acacagtaat 604441 gtacgtagga gcgaaaacag ggcgtgacgg catccacggc gctacgtttg cttctgaaga 604501 aatgtcagac tcgtctgaag aaaagcgttc tgctgtccaa gtcggcgatc cgtttatgga 604561 gaagcttttg cttgaagcat gtctggaagt catccaatgc gacgccttag tcggcattca 604621 ggatatggga gctgccggtt taacaagctc aagtgcagaa atggcaagta aagccggttc 604681 tggcattgaa atgaatcttg acctgattcc tcagcgcgaa acaggcatga ccgcgtatga 604741 aatgatgctt tctgaatcac aagaacggat gcttttggtt attgagcgcg gacgtgagca 604801 ggaaatcatc gatatttttg acaagtatga tcttgaagcg gtttctgtcg gacatgtgac 604861 agatgataaa atgcttcgcc tgacacataa aggagaggtt gtgtgcgagc tgcctgttga 604921 tgccttggca gaagaagcac cggtttacca taagccttct caagagcctg cttactatcg 604981 cgagtttttg gaaacagacg ttccggctcc gcaaattgaa gatgcgaatg aaatgctgaa 605041 ggcccttctt cagcagccga cgattgcgag taaagagtgg gtttatgatc agtatgacta 605101 catggtgcgc acgaatacag ttgtcgctcc tgggtctgat gctggtgttc tcagaatccg 605161 cggaacgaaa aaggcgctgg cgatgacgac agactgtaac gcgcgttatc tctatcttga 605221 tcctgaagtc ggagggaaaa ttgctgtcgc tgaagcagcg cgcaacatca tttgctcagg 605281 cgcagaaccg cttgcggtga cagataacct taacttcgga aaccctgaga agccggaaat 605341 cttctggcag atcgaaaaag cggcagacgg cataagcgaa gcgtgcaatg ttctcagcac 605401 tccggttatc ggcggtaacg tatcgcttta taacgaatca aacggcacgg cgatctatcc 605461 gacaccagtt atcggcatgg tcggcctaat tgaagataca gcgcacatta caacacagca 605521 tttcaaacaa gcaggagatc tcgtatacgt gatcggcgaa acaaaaccag agtttgccgg 605581 aagcgagctg caaaaaatga cagaaggccg tatttacggc aaagcgccgc aaatcgatct 605641 tgatgtagag ctgtctcgtc aaaaagcact gcttgacgcg attaaaaaag gcttcgttca 605701 atctgcgcat gatgtgtctg aaggcggctt aggcgtagcg attgcggaaa gtgtcatgac 605761 gacggaaaac cttggcgcta atgtgactgt agaaggggaa gcggcgttat tattctctga 605821 atctcaatct cgcttcgtcg tttcagtgaa aaaagaacat caagctgcgt ttgaagcaac 605881 tgtcaaagat gcagttcata ttggtgaggt aacagctgac ggaattctgg cgattcaaaa 605941 ccaagacgga caacaaatga ttcatgcgca aacgaaagag cttgaacgcg tatggaaagg 606001 agctatccca tgcttgctga aatcaaaggc ttaaatgaag aatgcggcgt ttttgggatt 606061 tggggacatg aagaagcccc gcaaatcacg tattacggtc tccacagcct tcagcaccga 606121 ggacaggagg gtgctggcat cgtagcgact gacggtgaaa agctgacggc tcacaaaggc 606181 caaggtctga tcactgaagt atttcaaaac ggcgaactca gcaaagtaaa gggaaaaggc 606241 gctatcgggc acgttcggta cgcaacggct ggaggcggcg gatacgaaaa tgttcagccg 606301 ctcctcttcc gttcccaaaa caacggcagc ctggcgcttg ctcataacgg aaatcttgtc 606361 aacgccactc agctgaagca gcagctcgaa aatcaaggga gcatctttca aacctcttcg 606421 gatacagagg ttttggctca cctgatcaaa agaagcggac acttcacgct gaaggatcaa 606481 attaaaaact cgctttctat gctgaaaggc gcctacgcgt tcctgatcat gaccgaaaca 606541 gaaatgattg tcgcacttga tccaaacggg ctgagaccgc tatccatcgg catgatgggc 606601 gacgcttatg tggtcgcatc agaaacatgc gcatttgacg tcgtcggcgc aacgtacctt 606661 cgcgaggtag agccgggaga aatgctgatc attaatgatg aaggcatgaa atcagagcgt 606721 ttttccatga atatcaatcg ttccatttgc agcatggagt acatttattt ctccagacca 606781 gacagcaata ttgacggtat taatgtgcac agtgcccgta aaaaccttgg gaaaatgctg 606841 gctcaggaat ccgcagttga agctgacgtc gtaaccgggg ttccggattc cagtatttca 606901 gcggcgatcg gctatgcaga ggcaacaggc attccgtatg agcttggctt aatcaaaaac 606961 cgttatgttg gcagaacgtt tattcagccg tcccaggctc tgcgtgagca aggcgtcaga 607021 atgaagctgt ctgcggtgcg cggggttgta gaaggcaaac gcgtcgtgat ggtggatgac 607081 tctatcgtgc gaggaacaac tagccgccgg attgtcacga tgctaagaga agcgggtgcg 607141 acagaggtgc atgtgaaaat cagttcaccg ccgatcgctc atccgtgctt ttacggcatt 607201 gacacttcca cacatgaaga actgatcgcg tcttcgcatt ctgttgaaga aatccgtcag 607261 gaaatcggag ccgataccct ctcatttttg agtgtggaag ggctgctgaa aggcatcggc 607321 agaaaatacg atgactcgaa ttgcggacag tgtctcgctt gctttacagg aaaatatccg 607381 actgaaattt accaggatac agtgcttcct cacgtaaaag aagcagtatt aaccaaataa 607441 aacttgaaaa atgacataaa ggcagcgcag ttcggctgcc tttctctttc tgccctcgtt 607501 cggggagata ttttgaaaag cgccttaaag gagtgaatag gatgtctgaa gcatataaaa 607561 acgcaggagt tgacatcgaa gccggatatg aagctgtaaa acgaatgaaa aaacacgtgg 607621 agcgcacgaa acggcttggc gttatgggca gccttggcgg ttttggcggc atgtttgacc 607681 tgtctgagct ttcttatcaa aaaccagttc tcatttcggg aacggacggt gtcggcacaa 607741 aattaaagct cgctttttcc atggataagc atgacacgat tggcgtggat gctgttgcaa 607801 tgtgtgtcaa tgacgtgctg gcacaaggtg cagagccgct gtttttcctc gattatttag 607861 cggttggcaa agcggaccca gtgaaaattg aacagattgt acaaggtgtt gcggaaggct 607921 gtgagcagtc aggttcagcc ttagtcggcg gtgaaacggc tgaaatgccg gggctctata 607981 cagctgatga atacgatatt gccggtttct cagtcggagt ggcagaaaag gacgaaatcg 608041 tgactggaga aaaaattgaa gagggccatc tgttgatcgg cctcagctcc agcggccttc 608101 acagcaacgg cttttccctt gtcagaaaag tgcttctgga tgatgcggag ctggacctcg 608161 atacaacata tgagccgttt gaacgcccgc ttggcgagga attgcttgaa ccgacaagga 608221 tttacgtgaa gcctgtgctt gccgcggtca aaagcggaaa aatcgacggc atggcgcacg 608281 tgacaggcgg aggatttatt gaaaatattc cgcgtatgct tccggaaggc ttaagtgcgg 608341 aaattgatca tggctcatgg ccgatcccgc cgattttttc tttcttgcaa gagtacggca 608401 agctaaagga agaagacatg ttcaacgtct ttaatatggg tatcggtttt gttttggcag 608461 tcaaagaaga gcatctgaca gatgtgatcg gaacgcttga aagccatggc gaaaaagcct 608521 atttaatcgg gcgtgtgaaa aaaggtgaag gcgtcacatt cggcggtgcg gcactttcat 608581 gaaaaagttt gcggtatttg catcaggaaa cggttcaaac ttcgaagcca tcgtcacgcg 608641 tttgaaggag gagaactggg atgcgtcagc agcgctcctc gtttgcgaca aaccgcaggc 608701 gaaagtcatc gaacgggcgg aagcattcca cattccatcc ttcgcatttg agccgaagtc 608761 ttatgaaaac aaggctgcat ttgaacaagc catcattgaa cagcttcgtc ttcacgaggt 608821 tgaattgatt gctcttgccg gctatatgag gctgatcggt gatacgctcc ttcaagcata 608881 tgggggaaaa atcattaaca ttcacccatc gcttcttccg gcgtttcctg gaatcgacgc 608941 agtcggacag gcgttccggg cgggtgtgaa ggtggccgga atcaccgtgc attatgtcga 609001 tgaaggaatg gatacaggtc cgatcatcgc tcaaaaggca atcgaaattg atgaacatga 609061 tacattggaa acaatcgaac agcgaattca caagcttgag cataaatggt atccgagtgt 609121 gattaaacag ctattaggat taaataacag aggtgaaaag gcatgaccat taaacgtgca 609181 ttaatcagtg tttcagataa aacaaatctc gttcctttcg taaaagaact gacagagctt 609241 ggcgttgaag tcatctccac aggcggaacg aaaaagcttc ttcaagaaaa cggtgtggat 609301 gtgatcggaa tttctgaagt gacaggcttt cctgaaatta tggacggccg gttaaaaacc 609361 ctacacccga atattcacgg cggccttctg gcggttcgcg gcaatgaaga gcatatggcg 609421 cagatcaatg aacacgggat tcagccgatt gacctcgttg tcgtcaacct ctatccattt 609481 aaagaaacga tttctaaaga agacgtcacg tatgaagaag cgatcgaaaa tatcgacatc 609541 ggcggacctg gcatgctgcg cgcggcatca aagaaccatc aggatgtcac ggttatcgtc 609601 gatccggccg attacagccc agtgctaaat caaatcaaag aagaaggcag cgtatctctt 609661 cagaaaaaac gcgagctcgc ggcaaaagta ttccgtcata ctgcggcata tgatgcactg 609721 atcgctgact atctgacaaa tgttgtcggt gaaaaagaac cagagcaatt cactgtgaca 609781 tttgagaaaa aacaatcgct tcgctatgga gaaaacccgc atcaggaagc aactttctat 609841 caaacagctc ttcctgtcaa aggctccatt gcgcaagcag aacagcttca cggaaaagag 609901 ctttcttaca acaacattaa agacgcggat gctgcagttc aaatcgttcg tgaattcact 609961 gaaccggctg ctgttgctgt gaagcatatg aacccgtgcg gcgtgggaac aggaaaaacg 610021 atcgcagaag cgtttgacag agcgtttgaa gcggataaaa catctatctt cggcggcatt 610081 atcgcgctga accgtgaagt ggacaaggca actgccgaag cgcttcacaa cattttctta 610141 gaaatcatca ttgcgccttc attcagccaa gaagcgctcg acgtcctgac tgcgaagaaa 610201 aatctccgtc tgctgacgct tgacgtatcc gccgctgttc aaaaggaaaa acagctgaca 610261 tccgttcaag gcgggctgct gattcaagat ttagatatgc acggcttcga tgatgctgag 610321 attagcattc cgacaaaaag agagccgaac gagcaagagt gggaagactt gaagcttgct 610381 tggaaagtcg tgaagcatgt gaaatcaaat gcgattgttc tcgcgaagga caacatgaca 610441 gtcggcgtgg gagcaggcca aatgaaccgc gtcggatcgg caaaaatcgc aatcgagcaa 610501 gcaggggaaa aagcgaaggg cagcgcgctc ggttcggatg catatttccc aatgccagat 610561 actgtcgaag aagcggcaaa agcgggcgtt acagccatca ttcagccagg cggatcgatc 610621 cgagatgagg attccatcaa aaaagcggat gaatacggca ttgccatggt attcaccggc 610681 atcagacact tcaaacatta aggggatgaa aacgacgtga atgtattaat tatcggtaaa 610741 ggcggaagag aacatacgct ggcgtggaag gcagcgcaaa gcagcctcgt cgagaatgta 610801 tttgccgctc ccggaaatga cggcatggca gcttccgctc agcttgtaaa cattgaggaa 610861 agcgaccacg cagggcttgt ctcatttgca aaacaaaatc aggtcggcct gaccattgtc 610921 ggccctgagg ttcctttaat tgaaggtctg gtggatgaat tcgaaaaagc gggcttacat 610981 gtgttcggtc cgtcaaaagc tgcggcgatc atcgaaggaa gcaaacagtt cgctaaggat 611041 ttaatgaaga aatacgacat tccgaccgca gaatacgaga cgtttacatc ctttgatgag 611101 gcgaaggcat atgtgcagga aaaaggtgct ccgattgtga taaaagcaga tggacttgca 611161 gctggaaaag gcgttactgt ggctatgaca gaggaagaag caattgcgtg cttgcatgac 611221 tttcttgaag atgaaaagtt cggtgatgcg agcgcgtccg ttgtcattga agaatatctt 611281 tctggtgaag aattttctct aatggccttt gtcaaagggg aaaaggtgta tccgatggtg 611341 attgcccagg atcacaagcg ggcgtttgac ggagacaaag gcccgaatac aggcggcatg 611401 ggcgcctact cgccagttcc gcaaatttcg gaagaaacgg tccgccatgc tgtagaaacg 611461 atcgttaagc cggctgcaaa agcaatggta caagaaggcc gttccttcac tggcgttttg 611521 tacgctggat tgatgcttac tgaaaacggc tcgaaggtca ttgaatttaa tgcccgtttc 611581 ggcgatccgg aaacacaggt cgtgcttccg cgcatggaat ctgatctggt acaggtgctt 611641 cttgatcttt tagatgataa ggaagttgac ttaagatgga aggataccgc ggcagtgagt 611701 gttgtgcttg catcagaagg gtatccggaa agctatgcaa aaggcacgcc gatcggcagc 611761 cttgcagcag aaactgagca ggtcgtggtc ttccatgccg gaacgaaagc agaaggtgga 611821 gagttcgtta caaacggggg gcgcgtcgcc aatgtgacgg cttttgatga aacgtttgaa 611881 gcggctagag accgagtgta caaagcggtt gatgaaattt tcaaaccggg actctttttc 611941 agaaaagaca ttggggcacg cgctttaaag gctgcccaaa aataagtgag gaaaacccgc 612001 agaatagctg cgggtttttt gttatcaaaa agcgggatgg cagctagaag aagaaagcac 612061 aacgagcgtg gttggttttc catgggccat cgaggtgtca ataaaatcct caagcgtatg 612121 taccgattca gtcacgacct ttgtcacata gctgtacatc cccgtgatgc ggtggttttc 612181 tgctacatca ggatgcgatg ttgcaaaggc ggcgtagtgc ttgcagcttt tcggctccat 612241 gagaataaaa gcggtgacat gcttgtttag tttttcgtaa cagatattcg cgctgtagcc 612301 ggtaatcact cctttgtctt ccagcttcct gacacgctcc gccgcgcttg gcgagctgag 612361 tccgacaagc tttcccagct caaccatcgt taatctgccg tttcgctgca aatgcgagag 612421 aatctgaagg tctgtatcgt ccatttgtct ggctccttta catatttagg cgaatgaatg 612481 aaaattcctt tgatcgtaag gtaatgctgt tgatttaact tcattgtagc atatggatgc 612541 cgtcttattt tttctataat aaagccatca atcagagagg gggcatcatg ttgccagaat 612601 tgcagcgctc tattacttgg atacaaggga cggcgttaac gattggggcg gttttaggat 612661 gcgggatatt aatcctgccg tctgtcaccg cggacacggc cggccccgct tctttatttg 612721 tttgggtgtt catgtccttc ttatcctttt ttcttgtcgg cacgctggcc cggcttgtga 612781 aaatagcgcc tagcgcggga ggaatcacgg cttatgtgca gctggccttt cagaaaaaag 612841 ccggggctat tttgggctgg atcatgttag ggtccgttcc gatcggcgtt cccatcatcg 612901 ctttgactgg cgcgcattac gtcagttaca tcacagaggc ggccgattgg cagattacat 612961 tgattgctgg ttgcatgctg gctatatcta ttttgcttca tatgagaggg attcaactat 613021 cagcaaacat tagtacactc gttatatgtg tcatcgtatt tctgcttgtc acttctattg 613081 ctgtgtcatt gccacacgtc acgatagcag aattcaagcc gtttcttccg catggctggt 613141 ctgccgctgg atctgtttct gttatgattt ttttctcttt tgtaggctgg gaaatgatta 613201 ccccgttggc tgaggaattt catcgtcctg aaaaagatgt cccgctcagc ttgtttttgg 613261 cagcgtcttg tgtggcgggg ctgtatatca tgctgtcatt tgtgaccgtg ggtactcatt 613321 catatggaga gaatggagaa attgcatcgc ttgccatgct catttcaaaa ggagcaggag 613381 aaagcggtgt atatgtcacg gtatgtttag cgctgtttat tacattcgcc accatccatg 613441 ccaatattgc cggtttttca agaatggtgt acgcattggc gagagagggg cacatacccg 613501 tattttttgg aaaactcagt gcgacaaaac gtacgcctat tcgcgttttg acagcgatgg 613561 ccgcagtgtt tggcttagtg cttgcagcgc atggtctgtt tcaaatcgat ttgacgactc 613621 tgttgaaagg gccgagcgcg gcttttatcg catcttacat atgtacaatg gcggcagcac 613681 tgaaactgct gggcaggaga gatataggct ggtggatggc gctcggggca tttgtggcgt 613741 gcgcggtgat ttattcattc agcggctggg cactgcttta tccggcagtg ctggcagctg 613801 caggatattt ctatatgaaa acaaagggtg ggcataaaaa aaagcttgat cacgttttgt 613861 gatcaagctt ttccatttat ccgttttgat gctcgttatt tccagaatcg ctgtgttgaa 613921 acatgtaggt cacaggacag aagcgcaaga ttcccgaacc cgctttcatg gcccccataa 613981 agatgtaaaa gagatgcatt ctgcaccaag gttttttcgt aaactttgca ctggcggctg 614041 acataatcgt caatccgcag gcgattctga acacggcatt gatgagactg atgtttggct 614101 tcaaggaaat ccgctccttt tacttaaaaa agttttttaa tcgaaccttc aaaaatttgt 614161 aacgttttta tcgtgcgtga tgaggaagga tgtgatacca tgagtctaat acatgtaaag 614221 gagagtatgt gaatgtccga acgcaccttt aactggaaaa acaaagacat cagggcacag 614281 gttgatgttg tagactcaaa gctgcttcca acgctccttt tacggaatgc tctcgtctta 614341 aatccatatg taaaacaatg gctgaaaaaa aacatttgga tttatcagga ccgcattgtt 614401 tatgtgggtc atgaacttcc gaatagagcc gaagaaattc atacgattga ttgtgaagga 614461 aaatacattg tgccaggtta tattgaaccg cacgcacatc cttttcaaat atataatccc 614521 caaacactgg cggaatatgt gtctcaatac ggaacaacga cattcgtgaa tgataactta 614581 tttttgcttt tgcaaagcgg aaaaaagaaa gcgcttacga ttttgaatga actcaaaaag 614641 cagcctgtcc agtatttttg gtggtcacgc tatgacctcc agaccgaggt tctgaacgag 614701 gaccacgtcc ttccatttga cgtcagaaaa cagtggattg aacatccgga tgtgattcaa 614761 ggcggagaaa tgaccggatg gcctcgcctg gtagatggtg atgatttaat gctccactgt 614821 atgcaagcta caaagaaaca gagaaaacgt attgaagggc attttcccgg cgcttctgat 614881 aaaacgctta caaaaatgaa gctgttcggt gcggattgtg atcatgaagc gatgacaggt 614941 gatgaagtga tgagaaggct ggaactgggc tattatgttt cccttcggaa ctcttccatt 615001 cgccccgatg taagaaaaat cttgcaagag ctgcatgaga agggcttccg ctattatgac 615061 cacttctttt acacgacaga tggcgcaacc ccgaatttct ataaaggcgg catgacaaac 615121 gagctgattc gcattgcgtt agaagaaggc gtacctgcaa tcgacgccta caatatggca 615181 tcatttaata tcgcaaagta ttaccaaatg gatgattatt taggagttgt cggaccgggc 615241 agactggcat cgctaaacat actggaagat ccgttaaatc cgaatccagt gactgttctg 615301 tcaaaaggga ccattctgcg tgaaaacggc tgtgatttga aggcgtttac aaagacggac 615361 tggcacaaag gcggtcttgt cccgcttgag ctttcatatg atatgacgat ggatgacttg 615421 cagttttcta tgccgatggg cgtgaaaatg cggaatgcgg ttattatgga gccatatatg 615481 attgagatcg acaattcgat ggaacagctc tcgtttgacc atgatgaaag ttatttgacg 615541 atgctcgaca gacacgggaa atggcgcgtc aatacgatga taaaagggtt tgcctcaagc 615601 gtgcagggat ttgtaagctc ctttacgacg acgggcgaca ttgtcgcgat tggaaaaaat 615661 aaagcggata tgctgctcgc tttcgcccgc atgaaagaaa tcggaggagg aattgtttta 615721 gcggagaacg gaaacattct gcatgaaatc ccgcttgcgc tgtgcggctg cgcctcttcg 615781 gaagcgtatg aagacgtgct tgagaaggaa caaaagctga gagatctttt gactgaaaga 615841 ggctatgagt tttgcgatcc tatctatacg ctgctctttt tgcaaagtac gcaccttccg 615901 tatatacgca ttacgccaag aggaatattc gacgtcatga aaaaaactgt actctttcca 615961 tcgataatgc gttaaaatat aaaagagcag ggagccgaca tatgaaaaaa tggatgacag 616021 tttgcgcgct gtgtttcgtg ttttttctgc tggtatcctg ccagcagaag gatgctgtcc 616081 cggatactgc aaagaagctg aaagctcctt taacggggct aaagactgaa cagaaagtga 616141 ctgaacgccg ccctgttgct gttgtggtga acaatcaccc gaaggcgagg ccgcagtcgg 616201 gtctgtctaa agccgacatt gtcatagaag cgctagccga agggcaaatc acaagatttc 616261 tggccatttt ccaaagccag atgcctgaaa ctgtcggacc tgtgcggagc gcgcgggaat 616321 atttcgtcac tctcagcaat ggctttgaca gcatatttgt ccatcacggc tggagtcccg 616381 gcgccaaaaa gcagctggaa tccggagctg ccgattatat gaacggattg gattttgacg 616441 gaagcttatt ttggagagct gatttcagca aaccgcccca caattcctat acgtcttatg 616501 attacataaa aaaggcggca gaacaaaagg gttataagct gaagcaggaa acaaatccgc 616561 tgctgtttca aacatcagat gcaaaacctg caaatgaatc ttacaatgtt cgggtagatt 616621 atggaacaaa taacgttaca aatcttgtcg aatacaacta tgataaaaaa gctgaatttt 616681 atacaagaag ctctgatggt gtcataacga cagaccggga aaccggaaag ccggttgcaa 616741 tgcaaaatat tttcattgtt gaagccagcc atcatattat tgatcaagat ggaaggcggg 616801 acatcgactt ggaatcagga ggaaaaggtc tgttgtttca gcacggaaac gtcattgaaa 616861 cagactggaa acaagtgaat ggcagaattg tgccggtaaa agacggcaag tggcttccgt 616921 ttgtgccagg aaagacttgg atcaatatcg tacctgatct tgatgcggct tccattagta 616981 aaggagaagg tgtgtaacga tgcaaatcga taaattacgc ggcaaagagc tggaccagtt 617041 atttaactcg atcttatcgc tgaaagacct ggaggaatgt taccgattct tcgatgatct 617101 atgcacaatt aacgaaattc aatcgctggc tcagcgcctt gaagtggcgc gcatgcttcg 617161 cgaaggaaac acgtatcata agattgaaac agaaacaggc gcttccacgg ctacgatttc 617221 ccgtgtgaaa cgctgcttaa attacggaaa tgacgcttat gaaatggcgc ttgaccgtgt 617281 gaaggagacg gaaacagagt cttcttccaa ataaaaaacc gccctgccgt ctggcaaggg 617341 cggtttcttt atgaaacaaa ttgatggatc aggttgtcga tattgatgat actgccatcc 617401 tctttccgat agacaacatg ctccttggaa aaatgaatcg gcgaattaat ccctgctgcg 617461 gctgcaaggt taaatagtcc ctcgcgcaat gaaataacgt agttgcagac acgatgctgt 617521 ttttcctcaa cgctcagtgc tttttgcaat ttcggatctg tcgtcgccac acctgccgga 617581 caggtgttgg tgtggcagac gagagcgcgg atgcagccaa cggaaaacat catgccgcgt 617641 gcgatgttaa caaagtcagc gccgagggct aaggcgaccg cgattttatc aggagtcagg 617701 agctttccgg aagcaaagat tttcagctgg ctgcgcaagc cgtactgttt aagaagcgtg 617761 tccacaatag gcagcgctgt cataatcgga aggccgactg tatccgcgag ctcgtaaaag 617821 gaagctccgg taccgccttc acttccgtcg atcgtgataa aatccggatg ctttccgctt 617881 ttctgcatat gagagaaaag ctcatgcaat tcttcaggat gccctgcgac cagtttgatg 617941 ccgactggct tttgtccgac atctctaagt ttttcaataa agtcgagcat ttcaggaggg 618001 tttgagaatt cataaaagcg gttcgggctg tcaatcgact ttccaggttc gacattccga 618061 atgtctgcca cttcctctga tactttggcg ccgtccacat ggccgccgcg ggttttcgct 618121 ccttgtgcca gctttagctc aaacgcttta atctggtcaa tcctgctttt tcttttaaat 618181 tcctcccacg aaaattcccc gtttcttttg cgcacgccga ataggcccgg tccgatttgg 618241 caaatgatat cggcgccgcc ctttaagtga tattcagaca atcccccttc acctgtattc 618301 atccaggtgc cgcctgccag atggagccct tttgagagcg ccgtaacagc ccgttctcca 618361 agagaaccgt agctcatggc agactggccg actaagccct tcacataaaa tggcttctcg 618421 catgtatgct cgccaatcac ctgtacatca tcaggatgga gaaaatacgg gtctgccttg 618481 atatgttcgg catgctcctt gcgtttgaac agattgtcag catccatttt atagatttgg 618541 gtttcaattt ttggcgtttg atttacatgc atttcttccc tttgttttgg aaacatagcg 618601 ttacggatat aatagccagg tttatcaaaa tctcttacag atccaaagcc catcattctg 618661 cttttgtatt tgccggagat gacggtttgc tcatattcct ttcgtgaaaa tggctgctct 618721 tcattgtcat tgctgtataa atactgtctg agctccggcc cgattttttc aaggatatac 618781 cgaaaccttc cgatgacggg atagttgcga agaattgagt gctcctgctg tttttcatcc 618841 tttatgtaga tccaggcaaa caagacgatc gggatagcga tgatcccaat gataaatgcg 618901 atgagtgcta ttatgatggt ttccatctct cagcctccct ttttatgtaa ccatttccac 618961 agtagaacac tttccaaaca atagcagaag gaatctggtg aaaaatgtgt gctcctgccg 619021 atacaggact caccatgcag gtactgccat atgctctctt tttttatgaa aaaagaatca 619081 aaacaccttt ttcagtgaat aacgagatta acggcttttt ccgtttttcc gcgctatgtg 619141 aatttgttat aatgtttaaa tggtaacaaa cgaatggagg aacgtatgac gtgtacgatg 619201 taacggagtg gaagcatgtc tttaaactcg atccaaataa agatttgcct gacgaacagc 619261 tggagattct ttgcgaatca ggaacggatg cggtcattat cggaggaagc gatggtgtga 619321 cagaggataa tgtcctgcgg atgatgtcta aggtaagacg gtttttggtg ccgtgtgtcc 619381 tagaggtatc agcgattgaa gcgattgttc ccggctttga cttatatttt attccgagtg 619441 tattaaacag caaaaacgcg gattggattg tcggaatgca ccagaaagcc atgaaggaat 619501 acggagaact gatgtctatg gaagaaatcg tggcggaggg ctactgcatc gcaaatccag 619561 attgcaaagc cgcggcactg actgaagcgg acgccgatct gaatatggat gatattgtcg 619621 cctatgcgcg tgtgtcggag ctgctgcaac tgccgatttt ttatttagaa tacagcggcg 619681 tgcttggaga catagaagct gtcaagaaaa cgaaggctgt attggaaacg tccaccttgt 619741 tttacggcgg cggcatcaag gatgcggaaa cggccaagca gtacgcagag catgcggacg 619801 tgatcgttgt aggcaatgcg gtgtatgaag attttgacag ggctttgaaa acagtagcgg 619861 ctgtgaaagg cgagtagtaa attgtacgga tttggtttat gatagaacgt atgttttgta 619921 taggcgggtg aacaaatttt gaattatatt agcaatcaat tactaagcgg tttaaacccc 619981 gttcagcagg aagcagtcaa aacaacggac gggcctcttt tgctgatggc gggagcgggt 620041 agcggaaaga cgcgtgtcct gacccataga attgcttatt taatggcaga aaagcatgtg 620101 gcgccgtgga acattctggc gatcacattt acaaataaag cggcacgcga aatgaaagaa 620161 cgtgtggaaa gcatcctcgg acccggcgcg gacgatatct ggatctccac attccacagc 620221 atgtgcgtgc ggatcttgcg cagagatatc gaccggattg ggatcaaccg aaatttctcc 620281 atccttgata cggctgacca gctttcagtg atcaagggga ttttgaagga gcgcaatctt 620341 gatccgaaga agtttgaccc gagaagcatc ctcggcacga tcagcagtgc aaaaaacgaa 620401 ttgaccgaac cggaggaatt ctctaaagtt gctggcggct actacgatca ggtggtcagc 620461 gatgtatatg ctgattatca gaagaagcta ttgaaaaacc agtcgctcga tttcgacgat 620521 ttaattatga cgacgattaa actgtttgac agagtgcctg aagtgcttga attttatcag 620581 cgcaaattcc agtacatcca cgttgatgag tatcaggata cgaacagggc acaatacatg 620641 ctcgttaagc agcttgccga gcgtttccag aacctttgcg ttgtggggga ttctgatcag 620701 tcaatctaca gatggcgcgg cgcggatatc accaacattc tttcatttga aaaagattat 620761 ccgaatgcaa gcgtgatttt gctagaacaa aactatcgtt caacgaaacg gattttgcgc 620821 gcggctaacg aggtcattaa aaacaactct aaccgcaaac cgaaaaattt gtggacggaa 620881 aatgatgaag gcatcaagat ttcctattat cgcggtgata atgagttcgg tgaaggacag 620941 tttgtggccg gcaaaattca tcagcttcac agcacaggca agcggaagct gtcggatatc 621001 gccatattat accggacaaa cgcgcagtcc cgtgtgattg aggaaacgct tctcaaagcg 621061 ggcttgaact ataacattgt cggcggcaca aagttctatg acagaaaaga aattaaagac 621121 attcttgcgt acctgcgcct cgtatccaat ccggatgacg atatcagttt cacgcgcatt 621181 gtcaatgtgc cgaagcgcgg agtcggcgcg acatcacttg aaaaaatcgc ttcgtatgcg 621241 gccataaacg gcttgtcctt tttccaagcg attcagcagg ttgattttat cggcgtcagt 621301 gccaaagcgg caaacgcgct tgacagcttt agacagatga ttgaaaacct gaccaatatg 621361 caggattact tatccattac agagctgaca gaagaaattc ttgataagac ggaatacaga 621421 gaaatgctga aggctgagaa atcgatcgaa gcccaaagcc gtttagaaaa tatcgacgag 621481 ttcctgtctg ttacgaaaaa ctttgaacag aaaagtgaag acaagacact cgttgcgttc 621541 ctgacagact tggcattgat cgcagatatt gatcagctcg atcagaagga ggaagagtca 621601 ggcggcaagg atgcgatcac cctgatgaca ctgcacgccg cgaaaggact ggagtttccg 621661 gttgttttct tgatggggct tgaagaaggc gtcttcccgc atagccgttc actcatggag 621721 gaagcggaaa tggaagaaga acgccgcctt gcgtacgttg ggattacaag ggcggaacag 621781 gagctttatc tgaccaatgc taaaatgcgc accttgtttg gccggacaaa tatgaacccg 621841 gaatctcgct tcattgctga aataccggat gatttattgg aaaacctaaa tgagaaaaaa 621901 gaaacaagag cgacgtctgc gagaaaaatg cagccgagac gcggccctgt ttcacgcccg 621961 gtatcctacg ccagcaaaac aggcggcgac accttgaact gggcagtcgg agataaggcg 622021 ggccataaaa aatggggaac aggaactgtc gtcagcgtga aaggcgaagg agaagggaca 622081 gagcttgata ttgccttccc gagccctgtc ggcgtgaaac gcctgttagc agcatttgct 622141 cctattgaaa agcagtaatt gaagaggaaa ggaagaagca gatggacaaa gaaacagcga 622201 agcagcgggc agaagaactg cgccgcacca tcaacaagta tagctatgaa tattacacct 622261 tagatgaacc gagcgtccca gatgccgaat acgacagatt gatgcaggag ctgatcgcga 622321 tcgaggagga gcacccagac ctcagaacgc ctgactctcc tacgcagcgc gtcggcggag 622381 ccgtgcttga agcgtttcag aaagtcaccc acggcacacc gatgctcagt ctgggcaacg 622441 cctttaatgc tgatgatctt cgtgatttcg accgccgtgt gcgccagtcc gtcggcgacg 622501 atgtggcgta taatgtggag ctgaaaatag acggtcttgc tgtttctctc cgttatgaag 622561 acggctattt tgtcagaggg gccacaagag gtgacgggac gacgggagag gatatcacgg 622621 agaatctgaa gacgatccgc aatatccccc ttaaaatgaa ccgtgagctg tcgatcgaag 622681 tgcgcggcga ggcgtatatg ccgaagcgtt cgtttgaagc actcaatgag gaacggatta 622741 aaaatgagga agaaccgttc gccaatccgc gaaatgccgc ggcgggatct ctcagacagc 622801 tcgatccgaa aattgcagcg aaacgaaacc tcgatatctt cgtctacagt atagcggagc 622861 ttgacgagat gggtgtagag acgcaaagcc aagggcttga ttttctcgac gaactcggat 622921 ttaaaacgaa tcaggaacga aaaaaatgcg gcagcataga agaagtcatt acgctgatcg 622981 atgagcttca ggcgaagcgc gcggacctgc cgtacgaaat agacggcatt gtcattaaag 623041 tcgattctct cgatcaacag gaggagctcg gttttacggc gaaaagcccg cgctgggcca 623101 tcgcgtataa gtttcctgct gaagaggtcg tgacgaagct tctcgatatc gaattaaatg 623161 tcggcagaac gggtgtgatt acgccgactg cgattcttga gccggtaaaa gttgccggca 623221 caacggtctc aagagcatcc cttcataacg aagatttaat taaagagaag gacattcgga 623281 ttttggataa ggttgtcgtc aaaaaagcgg gcgatatcat cccggaagtt gtgaatgtcc 623341 tcgttgacca gcgcacagga gaagaaaagg aattcagcat gccgacggaa tgtcctgaat 623401 gcggcagtga actcgtccgg atcgaaggag aagtggcgct tcgctgcatt aaccctgaat 623461 gtccggcgca aatccgggaa gggcttatcc atttcgtttc ccggaatgcc atgaacattg 623521 atgggctcgg cgaacgagtg atcacacagc tgtttgagga aaaccttgtc cgcaatgtgg 623581 cagatttata taagctgacg aaggaacgag tcatccagct cgagcgcatg ggcgaaaagt 623641 ccactgaaaa cctgatcagc tccatccaaa aatcaaaaga aaattcgtta gagcgcctgc 623701 tgtttgggct tggcatccgt tttatcggat caaaggccgc aaagacgctt gccatgcatt 623761 ttgaaagctt ggagaacctg aaaaaagcct ctaaagagga acttctcgcg gtagatgaaa 623821 tcggtgaaaa aatggctgat gctgtgatca cctattttca taaagaagaa atgcttgaac 623881 tcttgaatga acttcaggag ctgggcgtaa acacgctcta caaaggcccg aaaaaagtaa 623941 aagcagagga cagcgactct tactttgctg gtaaaacaat tgttctgaca ggaaagctgg 624001 aagagctgtc aagaaacgaa gccaaagcgc aaatcgaagc gctgggcgga aagctgactg 624061 gaagcgtcag caaaaacaca gacttagtca tcgccggaga agcggcggga agcaagctga 624121 caaaagcaca agagctgaac attgaagtgt ggaatgaaga acagttaatg ggagagctaa 624181 agaaataaga ggagtgtttt ctattgaaaa agacgttggc attggcggca acggcggcag 624241 tattaatgct gtctgcctgc tcgtcaggtt tcggggggga gaaggaggaa gagattacgc 624301 aaaagacggc gaaatcgtca gaaaaagcga ttgtcccgaa atataatatc tctgactcct 624361 attacaaaat ggtgctgccg tttaaggcag gcaaagcgcg cggcttaaca acggaacagc 624421 tgaatacaag gctggacatt gacgaatttg aaacagggct gatgcgcctt gcccaagatt 624481 ctttctcaac tgacgattat ctgttccaag aaggacaata tttagatgag gatacagtat 624541 taagctggct ggcacggaaa aaaacgggct ctgatttgaa aaaagccgaa aaagaagata 624601 agaacttcaa aaatgaaggc ttgaacccgg cgctcccgag ttctggttca acagaagaaa 624661 agaacgaaag cagcccaatt tatttagcat ccatgcttga gcacgattat ttagtcagaa 624721 aagacaagaa ttctatccag cttggcggcg tcatgatcgg actggcgtta aactcagtgt 624781 attactatcg tgaaaaaact ggcgacccgc aaaaagaagt ggagattaaa gacagcacgc 624841 ttcgccagca gggagaaaaa attgcacagg aggttattaa ccgcctccgc aaaaaagata 624901 acttgaagaa tgtgccgatt accgtggcgc tctacaagca ggcgtcaaaa acatcgattg 624961 tgccggggaa cttcatcgcc aaaacagagg tcaaagcagg ctctactgat atctcaaatt 625021 gggatgacat caatgaaaaa tatgtattct atccggcgga tacaaccaca gcagaaaagt 625081 acccggatga caccgaggtc tttaagcggt tcaaaaactc aattgaagaa tatttcccga 625141 actatacagg cgttgtcggt acagcgctgt atgaaaatga tgaaatgaag aaaatgaaga 625201 ttgacatacc aatgcaattc tacggaaaaa gtgaagttgt cgcgtttacc cagttcttaa 625261 cgggtgaagt gatggactac tactctaaga gctcagttga tgtcgaagtc aatatcacgt 625321 cctcagacgg acaggaagcg gtcattatcc gcaatgccgg agataaagag ccgactgttc 625381 acatttatga ctgatagaaa acccttgtgc catattggca caagggtttt tatgttacaa 625441 ttaacaggaa aagggaaaat attttcactt ctgccgaaac acaaatcaag gggaggtatg 625501 ttgatgctgg aaatcgtgtg aaaacaatca ttatcaaatc tatagcaatg aaaggatgtt 625561 agacgtgcat aaagatatca aaaaaatatt tcatgaagag caggttttgg cagaagctgc 625621 agcgagatac ggtttctcaa aagatcaggt gcgttttctg gctgatgcgg aaaactatgt 625681 atatgaatgt atgaaagaca atcaacctta tattttaaag attacccata cgattcggag 625741 atcttctgat tatatgatgg gagagatgga atggctccgt caccttgcaa tagggggaat 625801 ttcagtagcc aaaccgctcc cgtcgctgaa cggaaaagac gtagaagcag tgccggacgg 625861 aaacggcggg tcatttttat tgagagtgta tgagaaagcg ccggggcaaa aagtggatga 625921 atcggactgg aatgaaacgc tattttatga gcttggcaga tacacaggca gcatgcacag 625981 cctgacaaaa agctacaaat tgagcaatcc cgctttcaaa agacaggaat gggatgaaga 626041 ggagcaatta aagctgagaa aatatgtgcc tgaagatcag ataaaggtgt ttcagcaagc 626101 cgattctttg atgaatgaac tgcggaggct cccgaaaagc caggacaact acggcttggt 626161 gcatgcggat ctgcaccatg gcaattttaa ctgggatcat ggcaaaatca cggcatttga 626221 ttttgatgat atcggctaca actggtttgt taacgatatt agcattcttc tctacaatgt 626281 cctgtggtat cctgttgtgc catatgatga taaagctgcg tttacagaag aatttatgac 626341 gcattttatg aaagggtact gggaggaaaa tgagcttgac cctgcatggc tgatgataat 626401 acctgatttc ctccgccttc gccatatgct gatttacgga ttgctgcatc agatgtttga 626461 ccttaacaca ataggagaag aggaaaaaga aatgctggcc ggtttcagaa gagatataga 626521 gaatggcacg ccgattacag catttgattt ttcagcactg gtgtagatag aaaaagccaa 626581 tgggattcca gtcccattgg cttttataat gtatcacact tcacgccgac tacgccttca 626641 atggctttaa tgtcatagta gacatcggtc gtgtatctgt ttttatggac gcggaccttc 626701 acttccataa ttggaaaatc cttttcgcct aggtcgtcga tccgaacgga gtgtgctttg 626761 atatctcttc ttttcatttc ttttaaaatc tctgtcattt tgtctttatc agaaagtgac 626821 attctgatgc ggatgtcttt ttcctgcagg cggtcggggc cgatttttct gaccacccat 626881 gggagaaatt ccacactgat caggatgaac agaagactgg caaacgcttc tttataaaaa 626941 ccggctcccg tagcaagccc gagccccgct gccccccaga tcatggccga tgtcgtcagg 627001 ccggaaatga catcattgct ttttcgcagg atgacaccgg cgccgataaa cccgacgccg 627061 gagatgattt gtgccggcag acgaagcgga tccatcatga tgcggtagta tttagggaaa 627121 tgatatgccg cattaatact gacgatcgtc agcatgcatg agctgactgc gatgacaata 627181 caggttttta atccgagcgg cttatttttt aattcgcgtt caagcccgat gaccatgcca 627241 atcaatgtgg caatgcccaa tttcaataaa atatcaggat caatatacca gctcaacagc 627301 aaacttcccc cttctctatg gtgtttttaa ataaatatga ttttctcaca gtatttatag 627361 caaaacaaga gcacaaaagc caccaagctg cgcttgatgg cttattgctt actttttgcg 627421 ttttaacagc ttttccatga caccgaataa tcggtaagag gcttttgcag gacgttttgt 627481 gatcatgctg acaatgatgc cggcaatcat actgagaata aacccaggga tgatttcgta 627541 cacaccggtt gattttgcca ggccggttgt aatccagatc aacacggtcg cagccccgac 627601 aatcatggca gcaagcgcgc cccattcgtt cattcgtttc caatacagac tgagcagaat 627661 cgcaggcccg aaagctgaac cgaagccggc ccaagcgtat ccgaccaaat caagaatggt 627721 gctgttcggg ttcaatgaca agagtaccgc gataacggca atgactaaga cggacaatcg 627781 cccgatcatg accaattctt tatcagaagc ttttcgtctg aaaaatgacc ggtataaatc 627841 ctctgttaca gcacttgctg tgaccaagag ctgtgaggaa atcgaactca tgatggcagc 627901 caaaatagct gacaataaga accctgtaat taatgggtgg aacaagattt tagagaagat 627961 aatgaaaatc atctccggat cttttacagc aactccgaat ttatgggcgt atgcaacacc 628021 gattaaaccc gtcagcacgg aacctagaac tgtaatgatc atccagctca tgccgattcg 628081 gcgtgcaggt tttaaatctt taatgtcttt aatggccata aatcggacga tgatatgagg 628141 ctggccgtag tagcccaacc cccaggctaa ataggaaata atgctaatga cgctcgcgcc 628201 tttaaaaata tccaataaat gtggattaac agcgtcgatt tcatggaaag tcggagcaac 628261 gccgcccaca tgggtaaaag caacgatcgg cacaagcact agtgctgcaa acatgatcgc 628321 accctgcacg aagtcagtca gactgacagc aaggaaaccg ccaaacagtg tgtataacac 628381 gacaactgcg gtggtcagaa acaggcctaa tttgtaatcc gcaccaaaag cagattcaaa 628441 cagccgtccg ccagatacca taccggaaga ggtatacaat gtgaaaaaga tcatgatgat 628501 caatgcagat acgattttca gcagtgatga agaatgctgg aatcgtttat caaagaaatc 628561 aggaattgta atcgcatcat ctgccgcttc tgtataagca cgcagccttg gagccagcag 628621 caagtaattt gagtacgccc cgattgtaag acctaaagca agccataagg tggacagccc 628681 tgtcgcaaac atcgcgccgg gaacacccat cagcatccat ccgctcatat cggccgcgcc 628741 ggcagacaaa gcagtaacga atggtccgag gcctcttcct ccaagcatgt aatcattgat 628801 gtcagtggtt ttcttgaatg cataccagcc gattaacagc atggcaataa agtaaattcc 628861 taaagatata ataatttcaa tactcacgtt ttaccctctc ttcatttcta ataatgttgc 628921 atcacctctc aaattgatgg tgccagttaa gcagcctggc gtaagtgcaa aacaaaagaa 628981 attcttttgc gggtgcactt ggtaacttaa cctaacaaag tattcccggc cattcaagcg 629041 atgaaacatt gatcataagc tggaaatacc gttgcaaacc tagaagggaa taaagaataa 629101 aacgctttca aaaaataatt aaagtaaaaa tattcagaaa aatatttcgt ttctccttct 629161 cctcatttta gtataaaata tatagggtat tgtttcgaaa acacaggcct gtctcaaggc 629221 gttttgttgc tttaaagggc ttgtttttga tatgatcagt attatatgac ttaacggaga 629281 aatatgtgga ggtggatcat atgtcacgaa tttcaataga agaagtaaag cacgttgcgc 629341 accttgcaag acttgcgatt actgaagaag aagcaaaaat gttcactgaa cagctcgaca 629401 gtatcatttc atttgccgag gagcttaatg aggttaacac agacaatgtg gagcctacaa 629461 ctcacgtgct gaaaatgaaa aatgtcatga gagaagatga agcgggtaaa ggtcttccgg 629521 ttgaggatgt catgaaaaat gcgcctgacc ataaagacgg ctatattcgt gtgccatcaa 629581 ttctggacta aaggagggac acaagaatgt cattatttga tcataaaatc acagaattaa 629641 aacagctcat acataaaaaa gagattaaga tttctgatct ggttgatgaa tcttataaac 629701 gcatccaagc ggttgatgat aaggtacaag cctttttggc attagatgaa gaaagagcgc 629761 gcgcatacgc gaaggagctt gatgaggcgg ttgacggccg ttctgagcac ggtcttcttt 629821 tcggtatgcc gatcggcgta aaagataata tcgtaacaaa agggctgcgc acaacatgct 629881 ccagcaaaat tctcgaaaac tttgatccga tttacgatgc tactgtcgtt cagcgccttc 629941 aagacgctga agcggtcaca atcggaaaac tgaacatgga cgaattcgcc atggggtcat 630001 ctacagaaaa ctcagcttac aagctgacga aaaacccttg gaacctggat acagttcccg 630061 gcggttcaag cggcggatct gcagctgcgg ttgctgcggg agaagttccg ttttctcttg 630121 gatctgacac aggcggctcc atccgtcagc cggcatcttt ctgcggcgtt gtcggattaa 630181 aacctacata cggacgtgta tctcgttacg gcctggtcgc atttgcgtct tcattggacc 630241 aaatcggacc gattacacgt acggttgagg ataacgcgtt tttacttcaa gcgatttccg 630301 gcgtagacaa aatggactct acgagtgcaa atgtggacgt gcctgatttt ctttcttcat 630361 taactggcga catcaaagga ctgaaaatcg ccgttccgaa agaatacctt ggtgaaggtg 630421 tcggcaaaga agcgagagaa tctgtcttgg cagcgctgaa agtccttgaa ggtctcggcg 630481 ctacatggga agaagtgtct cttccgcaca gtaaatacgc gcttgcgaca tattacctgc 630541 tgtcatcttc tgaagcgtca gcgaaccttg cacgctttga cggcatccgc tacggctacc 630601 gcacagacaa cgcggataac ctgatcgacc tttacaagca aacgcgcgct gaaggtttcg 630661 gaaatgaagt caaacgccgc atcatgctcg gaacgtttgc tttaagctca ggctactacg 630721 atgcgtacta caaaaaagcg caaaaagtgc gtacgttgat taagaaggat ttcgaggacg 630781 tatttgaaaa atatgatgtt attgttggac cgactacacc gacacctgcg tttaaaatcg 630841 gtgaaaacac gaaggatccg ctcacaatgt acgcaaacga tatcttaacg attccggtca 630901 accttgccgg cgtaccggga atcagtgtgc catgcggatt agcagacgga cttccgctcg 630961 gcctgcaaat catcggaaaa cactttgatg aaagcactgt ataccgcgtt gctcatgcat 631021 ttgaacaagc aacagaccat cataaagcaa aacctgaact gtaaggggtg aaaagaattg 631081 aactttgaaa cggtaatcgg acttgaagtc cacgttgagt taaaaacaaa atcaaaaatt 631141 ttctcaagct ctccaacgcc attcggcgcg gaggcgaata cgcagacaag cgttattgac 631201 ctcggatatc cgggcgtcct gcctgttctg aacaaagaag ccgttgaatt cgcaatgaaa 631261 gccgctatgg cgctcaactg tgagatcgca acggatacga agtttgaccg caaaaactat 631321 ttctatcctg acaacccgaa agcgtatcag atttctcaat ttgataagcc aatcggcgaa 631381 aacggctgga tcgaaattga agtcggcggc aaaacaaaac gcatcggcat cacgcgcctt 631441 catcttgaag aggatgccgg aaaactgacg catacgggcg acggctattc tcttgttgac 631501 ttcaaccgtc aaggaacgcc gcttgttgag atcgtatcag agccggacat ccgcacgccg 631561 gaagaagcgt acgcatatct tgaaaagctg aaatccatca tccaatatac aggcgtttct 631621 gactgtaaaa tggaagaagg ctcacttcgc tgtgacgcca atatctctct tcgtccgatc 631681 ggccaagagg aattcggcac aaaaacagaa ttgaaaaact tgaactcctt tgcgtttgtt 631741 caaaaaggcc ttgagcatga agaaaaacgc caggagcagg ttcttctttc cggcggcgtc 631801 atccagcaag aaactcgccg ttatgatgaa gcaacgaaga aaaccattct tatgcgtgtc 631861 aaagagggat ctgacgacta ccgttacttc ccagagccag atctagtcga gctctacatt 631921 gatgatgaat ggaaggaacg cgtaaaagca agcattcctg agcttccgga tgagcgccgc 631981 aagcgttata tcgaagagct tggcttgcct gcatatgacg caatggttct gacgctgaca 632041 aaagaaatgg ctgatttctt cgaagaaacc gttcaaaaag gcgctgaagc taaacaagcg 632101 tctaactggc tgatgggtga agtgtcagct tacctaaacg cagaacaaaa agagcttgcc 632161 gatgttgccc tgacacctga aggccttgcc ggcatgatca aattgattga aaaaggaacc 632221 atttcttcta agatcgcgaa gaaagtgttt aaagaattga ttgaaaaagg cggcgacgct 632281 gagaagattg tgaaagagaa aggccttgtt cagatttctg acgaaggcgt gcttctgaag 632341 cttgtcactg aggcgcttga caacaatcct caatcaatcg aagactttaa aaacggaaaa 632401 gaccgcgcga tcggcttcct agtcggacag attatgaaag cgtccaaagg acaagccaac 632461 ccgccgatgg tcaacaaaat tctgcttgaa gaaattaaaa aacgctaata aaaaagcagc 632521 ccttagaggc tgcttttttt atggtcaaat tgagataaag acaagatgag ggcccgaagc 632581 ctttcaactt ctttgtcgtt ggttccggcc aaattggaca gcatgccttt aataatcggc 632641 ttgcgcggtt tatcctgagt caattcttcc tcgataacat caagtgacac ggtgatatcc 632701 tcgggcagcg tgctgttttc tttcactttc tgaatgtcct caagcagctg gtcttttccc 632761 gcaggcatcg ggttaaaaat gtcttttgat acaatcggat tgagtgcaga acggctcagc 632821 ccctgtacaa gatcatccag tctctcaata ataaaggctg agatttcttc tgcatcgata 632881 ttaagctcac cgttaaatac catcacgttc atataggaat gcacaatgcc tcttgccatg 632941 atggacagat ctgcgacata ccgctcgatt ccttcgccat aggataccag caaggcgttc 633001 cggtacagct tatccgtctc catggttact ttgtaaaagt attgcttgat ttcttgattt 633061 tccggaatga tattttcggt aagcaaaaga acgataaaat ctttatgatc gcgaaaatcc 633121 tcaaattgag cgccaatttg cttttttaac acttccttag gcggctttcc ggcgagatct 633181 tcttctatat ttttcatttt gttcatagac ataccgatat aatattcaca ggcagataac 633241 agcagcgctt ctttcgattt gaagtgcaaa taaaaagcgc ccttcgaaat gccgcattca 633301 ctggcgattt cttggatcgt cgtagctgcg aatccttttt tcgcaaataa acgaatgctg 633361 gtttttatga ttctctcttt tttttcattc atgacgtgct tccccttaat ccttgaaaaa 633421 tttagtaaaa ttttctggta tatgagttga cgttgttgcg ttataacgtt tagtattata 633481 tagaatgacc agtcagtcaa taaaaaatgt aatggaggat atgatgaacc acgttattaa 633541 tttcgttctg aaaaacaaat tcgccgtatg gctgatgacg attattgtaa cggcagccgg 633601 cttgtatgcg ggtatgaata tgaagcaaga gtctattcct gacgtgaaca tgccttactt 633661 gacgatcagc acgacatatc cgggtgcaac accaagccaa gtggctgatg aagtgaccaa 633721 accggttgaa caagccgtac agaacttgga cggtgtcagc gttgtgacgt cgacgtccta 633781 tgaaaacgca tcgtcggtca tgattgaata tgattatgag aaagatatgg acaaagcgaa 633841 aacagaagca gctgaagcgt tagaaaacgt caacctgcct gatgacgcga aggatccgga 633901 gatttcacgc tacagcttga actcattccc gattctgacg ctgagcgtgt ccagtgataa 633961 agataatctg caagagctga cgaaacaagt ggaggacagc ctcgtttcta agcttgaagg 634021 catagaaggc gttgcgtccg tccaagtatc aggccagcag gtggaagagg ttgaattctc 634081 tttcaaagaa gacaaactga aggaatacgg ccttgatgaa gatacagtca agcaagtgat 634141 tcaaggttca gatgtgacaa ctccgcttgg attgtacaca ttcggaaatg aagaaaaatc 634201 tgtcgtcgtc agcggcgata ttgaaacaat taaagatttg aagaatatga gaatcccgac 634261 ggcatctgct tcaagtgcag gcagcagcgc agcatctcaa gcaggtgcgc agagtgctca 634321 agcagcccaa agcgcgcaag cggcagcaca ggtgcagcaa agcgcaagca cagcagtgcc 634381 gacggtcaag ctttctgaca ttgctacaat taaagatgtg aaaaaagctg aatccgtttc 634441 acgcacaaat ggcaaagaca gcatcggcat caacatcgtc aaagcaaacg atgcgaatac 634501 ggtagaggtt gccgacgatg tcaaagctga gctgaaaaag ttcaaagaag accataaagg 634561 cttcaattac agcgcaactc tcgacatggc ggagccgatc acacagtcag ttgacacgat 634621 gttaagcaaa gccatcttcg gtgctatttt tgcgattgtg attattctct tattcttaag 634681 agatatcaaa tcaacattaa tttctgttgt ttcaattcca ttatcattgc tgatcgcact 634741 ccttgtgctg cagcagcttg atatcacatt gaatattatg acgctcggcg caatgaccgt 634801 tgccatcgga cgtgtagtcg atgactccat cgttgtgatc gagaacattt accgccgcat 634861 gagactcaaa gatgagccgc tccgcggaaa agccttggtt cgtgaagcga cgaaggaaat 634921 gtttaaaccg atcatgtcat caacgattgt gacaatcgcg gtattcctgc cgctcgcact 634981 tgtaggcgga caaatcggtg aattgtttat tccatttgcc ttaacgattg tttttgcgct 635041 tgccgcatcc ctagtgattt caatcacgct tgtgccgatg ctcgcacaca gcctgttcaa 635101 aaaatcatta accggtgcgc cgattaaagc gaaagaacac aaacctggca gacttgcaaa 635161 catctataaa aaagtattga actgggcgct gagccacaaa tggatcacgt ctatcatcgc 635221 ggttctgatg ctccttggaa gcttgttcct cgtaccgtta atcggtgcca gctacctgcc 635281 gtccgaggaa gaaaaaacga tgcagctcac atacagccca gaaccgggtg aaacgaaaaa 635341 agaagccgaa aatgaagctg aaaaagcgga aaaaatcctg cttgaccgca agcatgtcga 635401 tacggttcag tattcattag gctctggcag cccgcttgcc ggaggagatt ctaacggtgc 635461 gttattctat atcaaatatg aaagcgacac acctgacttt gataaagaaa aagataacgt 635521 tctgaaggaa atccaaaagc aatctgaccg cggagaatgg aagtcacagg acttcagctc 635581 ttcaggcaat aataacgaat taacatacta tgtgtatggc gattctgaaa acgatattaa 635641 agacacggtc aaagacattg aaaaaatcat gaaagatgaa aaggatctga aaaacgtaaa 635701 ttcaggcctt tccagcacat atgatgagta cacatttgtc gctgaccaag aaaaactaag 635761 caagctcggt ttaaccgcgt ctcaaatttc tcaggcctta atgtcacaaa catcgcaaga 635821 accgctcacc actgtgaaaa aagacggcaa agagcttgat gtgaacatta agacagaaaa 635881 agacgagtat aagagtgtga aagatttaga gaataaaaag atcacttccg cgactggcca 635941 ggaagtcaaa atcggcgatg tggcaaaagt gaaagaagga tcaacatcag ataccgtgtc 636001 aaaacgtgac ggaaaagtct atgcagatgt cacaggtgag gttacctctg acaacgtcac 636061 agccgtatca gctgctatcc agaagaaaat cgataagctt gaccaccctg ataacgtatc 636121 gattgacaca ggcggcgtat cagcggatat cgctgattcc ttcacgaagc tcggtttagc 636181 gatgctggca gcaatagcga tcgtttacct tgtgctcgtg attaccttcg gcggagcact 636241 agcgccattt gcgattctgt tctcattgcc gttcacagtc atcggtgccc tggtcggact 636301 ttacgtatca ggtgaaacga tcagtctgaa cgccatgatc ggtatgctca tgctgatcgg 636361 tatcgttgtc acgaatgcca ttgtcttaat tgaccgcgtg attcataagg aagcggaagg 636421 cctgtctacg agagaagcgc tcctggaagc cggctctaca cgactccgtc cgatcctgat 636481 gacagccatt gcgacaatcg gcgccttgat tccattagcc ctcggcttcg aaggcggaag 636541 ccaggtcatt tcaaaaggac tcggcgtaac ggttatcggc ggtttaatca gttcaacgct 636601 tctgacgctc ctgatcgtgc caatcgtata tgaagtattg gcgaagttcc gcaagaaaaa 636661 accgggaacg gaagaagagt aaaaaacaaa aagcctcagc tctgctgagg ctttcagctt 636721 gttgaaaaac cctcgcattc gttgtcaggt ctgcgcgtcg gtgctcacga attctacatt 636781 cgctccgctc caatgctccc ccttcctaga ctacaagggt tttcaatcaa gctgaaagaa 636841 tgttaaggat gacaaaagct caaaacaaga atcagttttg agcttttgtg cgttttcacc 636901 tgtaagatta tgtacatttt gttgcgattt ttttaactca tagtataatt aaaggttgtt 636961 agtgtaaaaa tggatcggat actcttaagt aggatgatga gataatgaaa cgtgcacgca 637021 taatatacaa tccgacttca ggacgggaga tctttaaaaa gcatcttgcc caggtcctgc 637081 aaaaatttga acaagccggc tatgaaacct ccacccatgc gacgacatgc gcaggagacg 637141 ctacacacgc tgccaaggaa gcggcattgc gtgagtttga cctgatcatt gcggcaggcg 637201 gagacggaac gatcaacgag gtcgtcaacg ggcttgcgcc tttagacaat cgtccgacac 637261 tcggtgtgat tcctgtcggc acaacgaacg acttcgccag agcgctcgga atcccacgcg 637321 aggatatttt aaaagcggca gatacggtca ttaacggcgt tgcccgcccg attgatatcg 637381 gacaggtcaa cggccagtat tttatcaata tcgccggcgg aggccgtctg acggagctga 637441 cgtacgacgt gccaagcaaa ctgaaaacaa tgctcggcca gcttgcttat tatttaaaag 637501 gaatggaaat gctgccttca cttcgtccga cagaagtcga gattgaatat gacggcaagc 637561 tgtttcaagg tgaaatcatg ctgtttttgg tcacgctgac aaactccgtc ggcgggttcg 637621 aaaagctcgc gccggattcc agcctgaatg acggcatgtt tgatttgatg atactaaaga 637681 aagcaaacct tgctgaattt atcagggtcg ccacgatggc gcttcgcgga gaacacatca 637741 acgaccagca cattatttat acaaaagcga accgcgtgaa agtcaatgta tcagaaaaga 637801 tgcagctgaa cctggacggc gagtacggcg gcatgctgcc gggcgaattc gtgaatctgt 637861 accggcacat tcacgtcgtc atgccgaagg agaaagcgga acagttggat gactaaaact 637921 tggcttggta agccaagctc agaatgttga caaaatccta aaacagtttt cgttttagga 637981 ttttgtcatc ttttcagcgt gattgaaaac ctttgaagtc taggaagggc gagcatcgga 638041 gcacagcgaa tgttgaattc gtgagcaccg aagcacaggc ctgacaacga atgcgaaggt 638101 ttgcctacac gctgaaactt ggcttgaata ggccaagttt ttctttcgct taaaactaga 638161 ggtgattata gatgaaaatg aaacccccag tagaaaaaaa tgaatactac gatgtgacat 638221 ttgaggattt gacacatgaa ggagcgggcg tcgcaaaggt ccaaggcttc ccgatctttg 638281 tgccgaatgc cctacccgag gaaaaagccc aaatcaaagt gacacgcgtc aaaaaagggt 638341 tcgccttcgg ccgcctgatt gagctgaagg aagaaagccc gcatagaacg gacgccccat 638401 gcccgattta caaacaatgc ggaggctgcc agcttcagca catgacctac gaaggccagc 638461 tcctgtttaa acagaaacaa gtcaaagacg tcttagaacg catcggcaag ctggaccttt 638521 caaaagtcac cgtgcacccg acactcggca tggaagaccc gtggaactac agaaacaaag 638581 cacaggtgcc ggtaggagaa cgggaaggcg gactcgtcgc gggattctat cagcaaagaa 638641 gccatgacat catcgacatg agcgcctgcc tgatccagca atccaaaaac gacgaagccg 638701 ttcaagctgt caaagacatt tgcgcaaact acggtgtcaa agcctacaac gaagaacgcc 638761 acaaaggctg gctccgccac atcatggtca gatacggcgt tgttacgggc gaaatgatga 638821 tcgtcttcat cacaagaaca agcgacttcc cgcacaaagc gaagatcatc gaagacatca 638881 cagcgcaatt cccgcacgtc aaatccatcg tgcaaaacat caacccaaac aaaacaaacg 638941 tcatttttgg caacgaaaca aacgtcatct ggggcgaaga atacatctac gacctcatcg 639001 gagacgtcaa attcgccatc tccgccagat cgttttatca ggtcaaccca gagcaaacaa 639061 aagtgctcta cgacaaagcg cttgagtacg ctgagcttca aggggaagaa accgtcatcg 639121 acgcttactg cggcatcgga acgatttctc tcttcctggc aaagcaggcg aaaaaagtgt 639181 acggtgtaga gattgtgccg gaagcaattg aggacgcgaa gcgaaacgcc gaattaaacg 639241 gcaacacaaa cgcagagttt gctgttggag aagcggaaac cgtgattcca aagtggtacg 639301 aagaaggcat tacagctgat acgctggtcg tcgacccgcc aagaaaaggc tgcgacgaag 639361 ccctcctgcg gacaattgtg gagatgaagc cgaagcgggt agtgtatgtg tcctgtaatc 639421 ctggcacgct tgcgagagat ttgcgggtgc ttgaggatgg cgggtacgtg acgcgcgaag 639481 tgcagcctgt ggatatgttt ccgcatacga atcatgtgga gtgctgtgtg ttgataaaat 639541 taaaagaata aatagtcaaa aatctatgct gatggaactg ttggttcgag ctcgcatgat 639601 cttctcagct acagcgtcga ggtgcaggaa gcagccacaa gagcgcaaat acgtgaactg 639661 gcgtcattta cagtgtgtcc gccgcatagg cgcgaattag aagaactgtc agcagagggt 639721 gtttatcagg agcaaatatt gaaaaaacga atttccatgc tggatctgct tgaaaagtat 639781 gaagcgtgtg acatgccgtt tgaacgattt ttagagcttt tacggccgtt aaaaccgaga 639841 tactattcga tttcaagctc tccaagagtg aatccgcggc aagcatcgat cacagtcggt 639901 gtcgtgcgcg gcccggcgtg gagcggccgt ggcgaataca ggggtgtggc atcaaatgat 639961 ttagctgagc gtcaagccgg tgatgatgtc gtgatgttta tccgcacacc ggaatcccgg 640021 tttcagcttc cgaaagaccc tgaaacgcca attattatgg tcgggccagg cacgggagtc 640081 gcgccatttc gcggtttcct tcaagcccgc gatgttttaa agcgggaggg caaaacgctc 640141 ggtgaggctc atctctattt tggatgcagg aacgatcggg attttattta ccgagatgag 640201 cttgagcggt ttgaaaaaga cggaatcgtc actgtccaca cagccttttc ccgaaaagag 640261 ggcatgccga aaacatatgt ccagcatctc atggctgacc aagcagatac attaatatca 640321 atccttgacc gcggtggcag gctttatgta tgcggtgatg gcagcaaaat ggccccggat 640381 gtggaggcgg cacttcaaaa agcgtatcag gctgtccatg gaaccgggga acaagaagcg 640441 caaaactggc tgagacatct gcaggatacc ggtatgtacg ctaaggatgt ctgggcaggg 640501 atatagataa agaagactgg agacatccag tctttttagt cctttcgaaa aaatggtgat 640561 cgcgctaaac attgatgcat acaataactt cagtccgccg gaagggcggg ctgtctgcaa 640621 aacctatttt tcgtttttgc tagtttatgt tattcttata ctcggtatct atttcttttt 640681 tcaaaggcac acatgacaaa agaaatcctt tttttatttc cgagaaaaaa atgtgaaacg 640741 aaatgaaggt ttctttcgtc cagtgattgg tttccaaatg gttgtaataa aaatgatatg 640801 gtgcgaaaca taaatattcc ggcttgccgc ggtgtattta ttgttgtgtg atgccttgat 640861 tttgtttgga aagaaggaat tggaaggcag gatataaaga gcaggtaaat atgaatgaag 640921 aacttaaagt gtttaagaaa gtagaggttg ccatgaagaa acttttttct tacaaactta 640981 gcttttttgt gctggctgtt atactgtttt gggcaaaaac gtatttatcc tacaagactg 641041 agtttaatct tggggtaaaa ggcacaactc aggagatcct cctgatattt aacccattct 641101 caagcgccgt cttcttttta ggactggctt tgctggcgaa agggcgtaaa tcagccatta 641161 ttatgctgat tatcgatttc ttgatgacat ttgtgttata tgcaaatatt ttattctatc 641221 gtttctttga cgatttcttg acgttcccga acattaaaca gtccggaaac gttggaaaca 641281 tgggagacgg gattttcagt atcatggccg gtcatgatat tttctatttc ttagatatta 641341 tcattttgat tgcggtattg atctggagac ctgaattaaa agaatacaaa atgaaaaaac 641401 gctttgcatc tttagtgatc ctttctggga tcgcactgtt tttcatcaac ctgcactatg 641461 cggaaaaaga ccgtccgcaa ctgctgacaa gaacgtttga ccgcaattat attgtgaaat 641521 atttaggttt atacaactac accatttatg acggtgtaca gacggctcaa acagagacgc 641581 aaagagccta tgcaagcagc gatgatttaa caagtgtcga gaattacacg acgtctcatt 641641 atgcgaaacc aaacgccgag tacttcggct ctgccaaagg caaaaatatc attaaaattc 641701 acctcgaaag cttccagtca ttcctgattg actacaagct aaacggtgaa gaggtgacgc 641761 ctttcttaaa taaacttgcg cacggcgggg aagatgtgac gtattttgat aacttcttcc 641821 atcagacagg ccagggaaaa acatctgatg ccgagctgac aatggataac tcgatcttcg 641881 gtcttcctga aggctccgcg tttgtgacga aaggcgaaaa cacctaccag tcgcttcctg 641941 cgattttaga ccagaaggaa ggctatacaa gcgccgtcct gcatggtgat tacaaatcgt 642001 tctggaaccg tgaccagatt tacaaacata tcggatatga caagttcttc gacgcaagca 642061 cgtatgatat gtcagatgaa aatgtgatta atatggggct taaggataag ccgttcttta 642121 cagaatcgat tccaaagctt gaatctctta aacagccatt ttatgcgcat ttgattacat 642181 tgacaaacca ttatccgttt aaccttgatg aaaaagacgc gtctcttaaa aaagcgacaa 642241 caggcgataa cacagttgac agctacttcc agacagcgcg ttaccttgac gaagcgcttg 642301 agcaattctt caaggagctg aaggaagccg gcctgtatga caactcagtc atcatgattt 642361 acggtgacca taacggtatt tctgaaaacc ataaccgagc gatgaaagag attcttggaa 642421 aagagatcac agattatcaa aacgcacaga accagcgtgt gccgctgatg atccgcgttc 642481 ctggcaaaaa aggcggagtg aaccatacgt atggcggcga aattgacgtc atgccgacac 642541 ttctgcactt agaaggaatt gattctcaga aatatatcaa ctttggtact gatttattct 642601 ctaaagacca cgacgatacg gtggcattca gaaacggaga cttcgtaacg ccgaagtaca 642661 catcagtcga caatatcatt tacgatacga agacaggtga aaaactgaaa gcgaatgaag 642721 aaacgaagaa tctgaaaaca agagtgaacc agcagctgag cctttcagac agtgtcctgt 642781 acaaagactt gctgaggttc cataaactaa atgatttcaa agccgttgat ccgtcagact 642841 atcattacgg caaggagaaa gaaatcaaat aagatgaaaa agagccttga gcgggcgcat 642901 tgccttcgct caaggctctt tttttggtta tacaaccaac ttgaaaaaat agattccatt 642961 tggtcaccaa ggctggcttt ctctcatatc attacagtag attttgaaac cggattgaaa 643021 tcggacaaat tatcggggaa atgccttgat agattgtgaa gatgtaccag gtttcgaact 643081 caatattcat agagatgagg ggtagagatg aaagcggtca ttctctgcgg cggaaaagga 643141 acgagaatga gtgaagtcac gaatgacatt cctaaaccgc tcgccatgat aggcggcaaa 643201 ccgattctat ggcatattat gaaaatttat cagtactacg gagtaaacga gtttattctg 643261 cttttgggct ataaaggaga aaaaatcaag gaatactttc tcgactatga atggaagcac 643321 aacagcctga cactcgacag ctctacggga gaggtacaga tgctggggca gcctgaaacg 643381 tggaaaatta cgtttttgga gactggggta gatacgctga cagccggaag aatcttgcag 643441 gcgaaagact atatcggtga tgaaacattt ctgctcacct atggagacgg gctggccaat 643501 atcaatcttt tccatctcat cagctatcat cagacaaaag gtgctgccgc gactgtcacc 643561 ggcattgaca aagtctcgca gtttggcacc ttgacagttg aggatggcat ggcgaaaaca 643621 ttttctgaga agacatcaag tgatggaatc atcaacggcg gattcttcgt tcttagtcca 643681 aaggttttcg attatttgcc gaaggacggg aacacgatgt tcgaagatga accgctgaag 643741 aaccttgcca aagatgggga gcttgctgtg taccgccatt acggattttg gacggccatc 643801 gatacgtata aaaatctctt agaagtcaac aaaatgtgga atcaaggaca acaagtatgg 643861 aaggtatggt gaattgattt gagtttctgg aaaaataaaa acgtatttgt cacgggatgc 643921 acaggtcttt taggaagcta tttggtgaaa gagctgatcg aacagggcgc aaacgttacg 643981 gggctagtca gggatcatgt gcctcaatcc aatctttatc agggagaaca tatcaagaaa 644041 atgaacatcg tgcggggctc tcttgaggac ttggctgtga ttgaacgcgc gcttggcgag 644101 tatgagatcg acacagtctt tcatcttgct gcacaagcga ttgtcggcgt ggcaaaccgc 644161 aacccgattt ctacctttga agcgaatatc ctcggcacct ggaatattct cgaagcctgc 644221 cgcaagcatc cgttaattaa gcgggtcatt gtcgcttcaa gtgataaagc ttacggcgat 644281 caagaaaacc ttccatacga tgaaaacatg ccgctgcaag gcaagcaccc gtacgacgtc 644341 tcaaaaagct gcgcagatct gatcagccac acctattttc acacgtacgg gcttccggtc 644401 tgcattacgc gctgcggaaa cttatacggc ggcggagatt tgaacttcaa ccgcatcatt 644461 cctcagacga ttcagcttgt gctgaacggg gaagcgccgg aaatccgaag cgacggcaca 644521 tttgtacggg actacttcta tattgaagac gccgttcagg cttatctgct tcttgcagaa 644581 aaaatggaag aaaacaatct tgccggagag gcctttaact tcagcaatga gatccagctg 644641 accgtacttg aactggtaga gaaaatatta aagaaaatga acagtaatct gaaacctaag 644701 gtgctgaatc agggaagcaa tgaaatcaaa catcaatatt tatccgcgga aaaagcaaga 644761 aagctgctga attggacacc ggcctacact attgatgagg gacttgaaaa aacgattgag 644821 tggtatacgg aattcttcaa aaagtaatgt gaaacgaggt gaacaagact gtgaccagcg 644881 cgtattgcac cgttttatca aaaggaagat tatatcaggc agtcgctttg tttaagtcgt 644941 tagagcaagt tgatcaagac agtcccattt ttatactttg catggatgaa gatacgcacc 645001 gcgtgttaca gaagctgaag atgaagcagc tgaaccttgt gccggtggcc gctcttgaaa 645061 atgaattgct gctgaagctg aaggaaacta gagatcaaag tgagtattgc tggacgatga 645121 agccgatctt tctgcaagct gtgctgaaca gcaatcctga gctggagcgt gtgacgtata 645181 ttgacgggga tctctttttc tatgcagatc catcgccgat ttttgaaaac cagccggact 645241 gctcggtgtt gctttcacga ggggatattg taatcccttc ttttgagaaa gagcagattg 645301 acatgctgca gcgtctttta ggcagatata attccgggtt tatcagcttc aagcatgatg 645361 atgcaggcac ggattgcttg gagtggtgga aggaacgctg tcttgaggaa tgcaaaaatg 645421 caccgggtga agggaaattc ggtgatcagg gctatttgga ttatatgtct gagctgtttc 645481 cgaatgtgtg tgacattaca acacccggcg tgaacatcgg ccattggaat tatggacagc 645541 atacgttttc ctggaaagat ggccggatcg tgctggagga tggcagtccg ctgatctttt 645601 atcatttcag cggataccga atcgtcagca tcaatgaaat caaacagatt catgaaacaa 645661 cccgcacaga tctgccgttt gtgcatgaac tgtatcaaga gacactgccg catatcattc 645721 agcacatgca aacgttagac cctgaattta acggttttgc ttcaaaagat gacaacaaat 645781 aaatgagtaa atacaggaag tgaaaatgaa gtgaaagcaa gcgttattat tcctgcatat 645841 aattcgaagg agcgtcttta caacagcctt ctgtcattaa accagcagga gtgcgatgaa 645901 gaatttgaag tcattgtagc ggacaatggc tctgaggacg ggacgctctc gatgcttgag 645961 tcatttcaag ctgattttcc gctgatcttt acacggatta aagaaaacag gggcattgcg 646021 tacggacgaa atcaggcgct tcgcaatgcc agaggagaca tcctgatttt ccatgacagc 646081 gatatgcttg cggcaaagga ccttgtggca aaacatatta aagcccatga gaacgaagag 646141 aatctcgtcg tgtgcgggtt gttttggaaa cggatctaca gtttttacta tgaacgattt 646201 gaagaagaac ataaggaaca gctcgcaaag ctcacaggtg aaatgccgaa gaaagacaaa 646261 caaaagctgc tggaggaagc ggacatcaaa aacggaagct ttcttgataa aagctttgac 646321 ctcgataccg actttataga cgtgctcaag aagattttag atgagtacgg cgatgacttg 646381 aaaggctatc atatgccatg gcgctttttt atcacgaata attcctctgt gaaacgcaag 646441 catgtggttg acctcggttt atttgacgaa ggcattgtgc ggtacgggtt tgaggattat 646501 gacctcggga tcaggcttca tcaggccgga ttgaccttca ggcttcgccg tgatattgtc 646561 agtgttcatc aggaacatcc aagcaattgt aagtctgtag acgatattcg ggcaaacatt 646621 gcctatatgt gcgataaata caataacatc cgctccttag acgttcatct cgcttttaat 646681 gggccgttcc cgcctgacat gacgaacaga atcatggctg atattcaaaa gctgctggaa 646741 tcacagaaat atgatatgct gctgaatctg tttcttgagc ttctgcatgt tgttaaagag 646801 cgcaacattg atccggattg gcgaaagaaa tccccaaggg tgacggcgaa aagctttgat 646861 ttgcaaactg tccgcaagct tctgcctaag gcgaagaaaa agctaggcgt gaacgatttt 646921 gccaacgcac tgtatgcgct tgtcaacgat ttgctgcacg tggatcttag atcattggat 646981 gtggtataag tgagtacatt tcatttttca acgatagtgt caaggacaca tatctttaag 647041 ctcatgccta tgattcattc tctccatgag cattgcgatg attttcattt atatgtgctg 647101 tgtgtcgacc agaaagcgta tgaattgctt cagcacgttc catgggagca tgtaaccttt 647161 gtgcagctgc atgaaatgga agacccggag ctgttgaaag cgaaaagcaa cagaacgttt 647221 catgaatatt gctggacgtt aaagcccgcc tttttgtttc atgtgatgag caagtgggat 647281 gacgctgaat actttgccca tatggatacg gatctatttt tcttttctga tccggcacgt 647341 atttttgcag aaaacccaac ggcgtctctg tatttgactg atcatcgtaa ttcgccgcgc 647401 ttcatgtcct actacgaccg aaccggacgc tttaatacag gctttgtcgg cgccggtaat 647461 acaaaggaag catatgaagc ggtgtggcag tggagacagg actgtattga attttgcacg 647521 gtcgaaatgg atacggaacg aaagacatat ggtgatcaaa gatatgtgga gaaatggccg 647581 gagcagttta aaggtgttca tgttgtcaaa tccataggag ccaatacagc gctttggaat 647641 atcgaaaact ataaggtcgg gcaaaaggac ggccgcgtgt atatagatga aacgccgctg 647701 attttctatc atttctctgg gtttacgctg gtgacagaaa aagagtttaa tctttgctgg 647761 tactaccgga ttgaagacga agcgacaatt aagatgattt atatgcccta tatattaaat 647821 ctgaaaagat ggattgatga aatacagtcg gcgtttccgg actttgcgga tggctttatc 647881 ccgaagcacg cagtgcctga cactcatttt atccagctgg attaaaaaac cccctgccgc 647941 ctggcagggg ttttttcagc tatgccattc tctcagcttc tggtcacttg gcaataggaa 648001 ggcaaggatg ccgaggacag ggagaaaggc aatggcgatc atcgtcgggg tcagtcccgc 648061 ggcatcaatc agagcgccca gcgccacagc gccgattgcg cccatcccga aggcaagccc 648121 gacggttaaa ccggacattg tgccgatttt tccaggaact agctcctgtg cgtagacgac 648181 cgttacagaa aagctcgaca tcagaaccaa gccaatcaat gcgagcacgc cgtaggcgag 648241 aaccgggccg gcaaatggca gcacaatcgc cagcggcgcc gagcataaca gcgaaccgag 648301 gataacgaag cgttttccaa aacggtctgc aagcgggccg ccgagaaacg tgccgatcgc 648361 gccgaacagc aagaagacaa aaatatagct ttgtgcctgc tgaatgctta cgtgataggt 648421 atccatcgcg taaaacgtgt aaaagttacc gatcgcactc gtataccaag aacgagcaaa 648481 aatgagaaat ataataataa taagagcaga tacaacagat ttggtgatgg ccgtgttttc 648541 agccgttttc ttttgcttgc ctgatttctg ggcaaggctg ccgagacgtg aggcgtacca 648601 tttcgcaata tacatgagaa acataacagc aagcgcggcg acaagcgtga accaaacagc 648661 gccgaattgc ccgagcggca caaggatcag cgcggtgatc agcggtgcca tcgcctggcc 648721 tgagtttccg cccacctgat aaatcgattg ggcgagcccg cgttttgtgc cggcggccat 648781 atacgccaca cgggagccct ccggatggaa aatggccgag cctaatccaa tgaaaaacac 648841 acagcataag atcgttatga atgacggggc aaatgcaagg cccaaaatgc caagcatgct 648901 ggcggtcaaa ccgactggca gcgcatacgg ccgcggccgt ttatcggtat accagccgac 648961 aacaggctgc atgacggatg acaccatgtt taatgtgaaa gcaatgatgc cgagctgtgt 649021 aaacgtcagg ctcatggagc gttccaaaat agggaacatg gccggaatca cagcctgaag 649081 cgaatcgttg agcatatggc aaattccgat aataatcaaa atcggataca ccgtggtgcc 649141 tggtttttga actgtttttt cttttaacgg ggcggcgata gccattgagt ctcctcctta 649201 catatataac caaagcatac caccatatta ttcataaggt gaagaattta tcaagaggaa 649261 aaaagattct tatgaaagaa ataccgtcag cctgattagc agctgacggt attttcgata 649321 ttcaaaatgt gatatagctc ttcaagctta cgaatctcat aggttggtat gatctctggc 649381 acattcggct tcatgtcagg gttcatccag caagtatcaa gcccggcgag ctgtccgcct 649441 ttgatatcag cagttagtga atccccgatg attaatgtgt gctctgctga aaattgagga 649501 atccgttcaa acacgtaatt gaaatattcc ttcatcggct tttggaagcc ggtgtcttca 649561 gaaacgaaaa tgtccttgaa gaatggaaat aatcctgaat cacggagacg cttatattgt 649621 gtgtgagaca cgccgtttgt cacgatgtac aaatcaaact gttgctgcag atttgagatg 649681 agatcaaatg caccgtcaat aagctgatgt ccttcttcaa gaaagcggcg gtatttttgc 649741 tcaagcaaag cgccgtccgc ttcgtaaccg tactccttga gcaaagcgga aaaacgtgtg 649801 tttacgactt catcccgtgt catcttacct tcttcaaagg ctctccagag accttgattg 649861 atggttttat actgcgcctt catgtcattt gttaaaggaa tgttctgatc ttcaaacagc 649921 aaacgcaggg ctaaagcttc tgccgcttga aaatcaagga tggtatcatc tacatcaaat 649981 aataaagtgc ggtatcgctt catctgtgtg tctccctttc tcatatgtat tcaaagtata 650041 gcacataaaa aaaggaaaaa gccggcgggt gaggcaccgc cggctgaaaa gagattattt 650101 gtttaataag ctgtgttttc tcgaatatag gaagtaaacc agcgttccga cagcgatcca 650161 gatgacaaat gaaagccatg tgacgccggg aaggctgtac atgaaccaaa ggcagatgcc 650221 tgcgctgata atcggcacaa ccggaacgaa tggcactctg aaggacgctt tgatttcagg 650281 atgtttcttt cttaacacaa tgacagcaat ggaaatgacc gtaaacgcgg caagtgttcc 650341 catgttcacc agatgggcca gcgttccgag gttaataaag ccggcgattc ccgctgcaac 650401 gatccctgtc agccatgtgt tgcggaacgg ggttttaaat gacggatgaa cctttgcgaa 650461 caatccaggc agaaggccgt ctctgctcat ggcaaatgtc aagcggacct gtgcgtacag 650521 caaagcgagc atcaccgtcg taatcccgat aatcgcaccg acagaaataa ttccggcaac 650581 agcgtcctgt ccgacgaatt tcagcgcaaa ggatacagga tctccgacat tcaatttggc 650641 ataaggcatc atgcctgtca gcacaagcga taccgcgatg tacagaaccg tacagacggc 650701 tagagctgaa ataatgccga cgggcatgtt tttttgcgga tttttcactt cctctgatgc 650761 gttagaaacc gcgtcaaacc caaggtacgc gaagaataca gtggcagcgc taagtatgac 650821 gcctttcatc ccgaatggca taaaaggaga ccagttatcc ggtttcacat agccgatgcc 650881 gacaataatg aacaataata tgatcgcgat tttcatcagt acgatgacgt tgttaaagcg 650941 tgtgctttcc ttgacgcctc tgctgacaat cgcagtgatg aggagaatga tcaccgcagc 651001 cggaaggtta aatacggcgc ccgccatgct tcccggcgct cctgtcagtg cagccggaat 651061 atgaagattg aagccggcaa gcagtgattg aaagtatgaa gaccagccgg tggcaaccgc 651121 cgacagtgca atgacatatt caagcatgag atcccatccg atcaaaaagg cgagcagctc 651181 tccaagtgtc acgtatgagt atgagtacac gcttcccgaa atcggaatgg aagacgaaaa 651241 ctcagcataa cagaaagcag ccagcgcaca ggcgagcccc gctaaaataa acgatatgat 651301 gagggcggga cctgcaccgg tcgctgccac tgttcctgta atgacaaaaa tccctgtacc 651361 gatgacacaa ccgataccga gcaaggttaa atcaaatgcg cttaacgtac gggcaaggct 651421 ttttgacttg ctctgcgcac tcaatgtttc aagcggtttt tttctaaata atgaactcat 651481 caaaagttcc tcctagaaat attcaaaata ttctaatcat tatatgcagt tcttgttgta 651541 ttatattgtc gaaatttgac gtagtcaata aaatattttt ctgctttaaa tgatagaagc 651601 gaaacagcgt tgtcgtatca taggatagta atttttacta atcgtatatt caattttatg 651661 caagatgaac cgatagaaaa aatagattcg cccatatttt gatttgcggt tataaaggag 651721 atgctgacca tgtttcaata tgaagagttg aataaacagt ttatcggcgg gaaatggcag 651781 gagggcagca gcccaaatgt attggaaaac aaaaatcctt atactcaaaa aacattcaca 651841 acattccgta aagcgactgc tgacgatgta gatgaagcgt atcgggcagc ggcgctggca 651901 aagaaaaaat gggatgcggt caacccgttc gagaaaagaa ccattttaga aaaagccgtc 651961 acgtatattg aagaaaatga agaagccatt atttatttga ttatggagga gctaggcggt 652021 acaaggctca aagcagcttt tgaaatcggt cttgtcaaaa acatcataaa agaagcggca 652081 acgttcccaa tccgcatgga ggggaaaatt cttccgtcaa caatagatgg caaggaaaac 652141 agattatatc gcgtgccggc aggcgttgtc ggtgtcatca gtccgtttaa cttcccattc 652201 tttttatcta tgaaatcagt ggcgcctgca ctcggagccg gcaatggcgt tgtgctaaag 652261 ccgcatgagg aaacgccgat ttgcggcgga acgctgattg cgaaaatttt tgagaacgcg 652321 ggaattccag cggggctgct gaatgttgtt gtcacagaca ttgctgaaat cggcgacagc 652381 ttcgttgagc atccagtgcc gcggatcatc tcatttaccg gttctacgaa agtcggcagc 652441 tacatcggac agcttgcgat gaagcatttt aaaaagccgc ttcttgagct tggcgggaac 652501 agcgccttca tcgtacttga ggatgcagat atagaatatg cggtcaatgc ggcggtgttc 652561 agccgattta cacatcaagg gcagatttgc atgtcagcca accgcgtgct tgttcattct 652621 tctatttatg acaagttcct tgagctgtac caggcaaaag tggaatcgct gaaagtcggc 652681 gacccaatgg accctgatac gattatcggg ccattaatca acagcagaca gacggacggg 652741 ctgatgaaga ctgtagagca agcaattgaa gaaggcgctg taccagtgaa gcttggcgga 652801 tttaacggga cgatcgtgga accgacgatc ttaaaagacg tcaaaccgtt catgagcatt 652861 gccaaggaag agctgttcgg accagtcgtc tcctttatga agtttgattc agaagacgaa 652921 gcggtggata tcgcaaacga aaccccgttt ggcttgagcg gtgccgtaca tacgtcaaat 652981 cttgagcgcg gcgtggcttt tgcgaaacgc attgaaacag gcatgattca cgtcaatgac 653041 acgaccatca atgatgaacc gaatgtagcc ttcggcggtg aaaagcaatc aggcctcggc 653101 cgtttaaacg gtgagtggag cctcgaagaa tttacaacgc tgaaatggat ctcggtccag 653161 cacgaaaaac gcagcttccc ttattaatga aaaggagtga atggaattga ccataaatac 653221 ggaaaaagaa accgcagata ttctggacgc atttatcaaa gtagcccctt atttaaacag 653281 cctggttcag gatgatatta caatcggcat ttatgatacg gaaaaactgc tcgtgaatat 653341 accggccaaa accttttcgc tgaacgtaaa agccggcgat ccgctgcagg aaggggatat 653401 catcacagat gccatccgca gcaatcagaa gaagacgagc atggttccga aagaattgtt 653461 cggcttccca ttgatcgcgc gtgccatccc gctgcacgac gagaatggaa gagtcattgg 653521 aggcgtcggc ctcggaacga gccttgagga gtcgtcaaag ctgcatgatg tcgcggaaag 653581 cttatcagct gttgttgaac aaacagccgc ggctatttcc gacatttctg aatcaattaa 653641 cgggttttca actcaaatgt cgggcatttc ctctcaggcg aaaaaagtaa gcgaaagcgc 653701 cggtgaaatc gccgatattt cagtaactgt taaaggcatc tcggaccaaa gcaatctgct 653761 cggcttgaac gccgcgatcg aagcggcaag agcaggggag tccggaaaag gattctctgt 653821 cgtcgcagat gagatcagaa agctagcgac gcattcaaaa gaaaatgtcg gccaaattga 653881 ccagattacg aaaaaaatcc acagcctgct gaaagggctg gaggaatcca ttgagtcgat 653941 taaccagcat acagacggac aagccgctgc tgttgaacaa atttccgcca cgatgcagga 654001 gatttcagga agcgcgcagc atcttgcgaa aatggccgaa aaagcgcttg aggaagagta 654061 agagaccggg gacaaacatc cccggtcttt ttcttatcct gcatttccat gaaattcgtc 654121 tgacgtttta ctagttttat tccagcggct gatttaaaat gtacacatga acttacgtga 654181 ggattgatag gaaccatgag catattaaaa gcggaaaatc tttataaaac atacggagat 654241 aaaacattat ttgaccatat ctcctttcat attgaagaga atgagagaat cggattaatc 654301 gggccgaacg gaacaggaaa atcaacgctg ttgaaagtga ttgccggctt ggaatctatc 654361 gaagaaggag aaatcacgaa atccggaagc gtgcaggtcg aatttcttca tcaagacccg 654421 gagctgcctg cggggcaaac agtgctggag catatctatt ccggtgaatc ggctgtgatg 654481 aaaaccttgc gtgaatatga aaaagcgctg tatgaactgg ggaaagatcc cgaaaatgaa 654541 cagcgccaga aacacctgct ggcagcacaa gcgaaaatgg acgcgaacaa tgcatgggat 654601 gcaaacacct tggcaaaaac cgtattgtct aagctgggcg tcaacgacgt aacaaaaccg 654661 gtcaatgagc tctcaggcgg ccagaaaaaa cgggtggcca ttgccaaaaa cttaattcag 654721 cccgctgatt tgctcatttt ggacgagccg acaaaccatt tggataatga aacgattgag 654781 tggcttgaag ggtatttaag ccaatatccc ggcgccgtca tgctggtgac gcacgataga 654841 tatttcttaa accgtgtcac caaccgcatt tatgagcttg aaagaggcag cctctacact 654901 tacaaaggca actatgaagt gtttttagaa aaacgcgcgg aacgggaagc gcaggctgag 654961 caaaaggaaa cgaagcggca aaacctgctg cgccgcgaac tggcttggct cagacgagga 655021 gcgaaagccc gctccacaaa acaaaaagcg agaattgacc gggtagagac gcttaaagag 655081 cagacaggcc ctcagtcatc aggttcactc gattttgcca ttggctcgca ccgtctcgga 655141 aaacaggtta ttgaagcgga gaacgtcatg atcgcttatg acggccgcat gctcgtcgac 655201 cgttttaatg aacttgtcat accaggtgaa cggatcggga tcatcgggcc gaacggcatc 655261 gggaaaacaa cgctgttaaa tgcccttgcc ggccgtcata cgccggacgg aggcgatatt 655321 acgatcggac agacggtcag aatcggctac tatactcagg atcatagtga aatgaacggt 655381 gagttaaaag tcattgacta tataaaagaa acggcggagg tcgtaaaaac ggcagatggc 655441 gatatgatta cagctgaaca aatgctcgag cgtttcctct tcccgcgttc gatgcagcag 655501 acgtatatcc gcaagctgtc cggcggggaa aaacgccgtt tatacttgct tcaggttctc 655561 atgcaggagc cgaatgtcct gtttctcgat gagccgacga acgatttgga tactgaaaca 655621 ttaagcgttc ttgaggatta tattgaccag ttcccaggcg tcgtcatcac cgtatcccat 655681 gaccgctatt tccttgaccg cgtcgtcgac cgtttgattg tatttgaagg aaatggtgtc 655741 atttcccgct ttcaaggctc ctatagcgac tatatggagg agtcaaaagc gaaaaaagcg 655801 gccccaaaac cggcagctga ggaaaaaacg gctgaagccg agccgaagaa aaaacggaaa 655861 aagctttctt acaaagacca gttggaatgg gacggcatcg aagataaaat tgcccagctg 655921 gaagaaaagc atgaacagct tgaagctgac atcgccgcag caggcagtga ttttggcaaa 655981 atccaagagc tgatggccga gcaggcgaaa acggcggaag agcttgaggc tgcgatggac 656041 cgctggacag aattgtccct catgatcgaa gaactggaaa gctaaaaagc gtggccgcag 656101 caggccgcgc tttttttcac ataatggaca aaaacgaacc ggcctgctta tgttaggata 656161 aagttgtgtg tcagcggcac atggaaaact aacggagatg atgaagtatg acatgggcga 656221 tcgtgatgtt aattctcatg agtctggtga aaatcgtatt aacctgtctt cctacaggcg 656281 tcatagaatg gctgctcggc aaatttgaag tgcacgccaa gctgagtgac gaaaatgcga 656341 gtctctctct agatggaaaa cgcctcgagg gtgcagagaa gcagaaagtg attgatcaat 656401 ttaacgaagc tatcttcctg gaaaaatatt atatctatcc aggtgatgaa gagcgttatt 656461 tacatccgga aaacggcggc acgcctctgg tgatagatac aaaaaaagga aaaaaagacg 656521 tgaagctgtt cgtgtaccgc tacgacgacc atatcgacgt cgtgaaacag tacaagaaga 656581 aagtgatcgc gtatcgagtg ctttctgaaa gccttcaaaa agagtctctg tcagtggcgg 656641 gaagtttagc ttaaacagga aagtgaaaga cgggtgctgt atgctgctcg tcttttttat 656701 tgttttttaa aacttaacgt ttacgttaag gttcaaaagg tgtataatgg taacagaaac 656761 ggcgaagggg gatttacctt ggaatggatg aagattgatc aagtggccaa aagaagcggg 656821 ctgacaaagc ggaccatccg gttttatgaa gaaatcggct tgattccggc gccgaaacgg 656881 acagacggcg gtgtaaggct ttattcagag gatgatatgg aggagcttga gaaagtcatc 656941 agcacaaaag aggtgctcgg tttttccctt caggagcttc agcatttcat ggaaaccagc 657001 cgccagctag agttaaacaa agaggggtat ttgttgtcac tggatcctaa ggaacggaaa 657061 gaaaaactgg aggaaattca ggaaaccctg aatcaccagc tggatttgat tgatgagaaa 657121 atccgcacat tccaaagctt taaagaacgc ctgcagggca tgaaaggcaa agcggaacgc 657181 gccattcaat caatcgaatg aaaagtttgt taaacgctat ttttgtagcg tttcttttaa 657241 tggaataaag atggaggtta ggtcaaatgg ataagacaac acaagtgaat cagaaaacgg 657301 gtttgctcag ccagccaaaa gcggtatggg ctgtcgcgtt tgcctgtgtg atttctttta 657361 tgggaatcgg gctggtcgat ccaattcttc cggccattgc cgcacaattg catgcttcac 657421 ctagtgaagt atcactcttg tttacaagtt atttgcttgt aaccggattt atgatgtttt 657481 tctcaggagc catttccagc cgcatcggcg cgaaatggac attaattctc ggacttattt 657541 ttattattgt gtttgcgggg cttggcggca gctcaagctc aatcgctcag ttagtcggct 657601 atcgcggcgg ctggggatta gggaatgctt tgtttatttc aacagcgctt gcggtcatcg 657661 ttggcgtgtc agtcggcggc agcgcccaag cgattatttt gtatgaggcc gcgctcggtc 657721 tcgggatttc tgtcgggccg cttgcaggcg gagagctcgg aagcatttca tggcgcgcac 657781 cgttttttgg agtatctgtc ctgatgttta ttgcgttaat cgcgatttct ttcatgcttc 657841 cgaagctgcc gaaaccggcg aaacgcgtcg gtgtgtttga tgcgatgaag gcactcaaat 657901 ataaaggcct gctgacaatg gcggtatcgg cattcctata caactttgga ttttttattt 657961 tgctagctta ttctccgttc gtactggatt tagatgaaca cggtcttgga tatgtcttct 658021 tcggctgggg ccttctgctg gcgattacgt cagtctttac ggcgccgctc gtgcacaaag 658081 cgctgggcac agtgcgttcg ctagtcgttc tctttatcgc ctttgcggcc attctcgtta 658141 ttatggggat ctggacagac catcagactt tgattattac atgtatcgtt gtcgctggtg 658201 ctgtcctcgg tatggtgaat acgatcatga caaccgctgt gatgggttct gcgccggttg 658261 aacgttcaat cgcgtcttca gcctacagct cagtccgctt catcggcggc gcgctcgccc 658321 cgtggattgc aggaatgctg tcagaacact ttactgcaag cacaccatat acagtaggcg 658381 gaatcgtcgt ttttgtcggc atgcttgtcc ttctcatggg acgtaaacat cttgctggaa 658441 ttaaggcggg gcattaataa cgaaagacac tgcgcatatg cagtgtcttt ttattcgtta 658501 taatgcatca taatcgaatt ggtgcaggaa aggacaacct ttatgacaca attttactat 658561 tttccggctg aaaactccct ttagaaaccg gttttttcgg tcagcaagaa cggcgttcgc 658621 ggaaagggca tccgcttcgg tcaggcattg atgcggctgg gatttatctt gcagaagctg 658681 agaatgtgtc cgttcattta cgattgccat ttcagtgatg gttcatgctg tagaggggac 658741 gtttgccatg gataaggcaa aacctgacga atatgatcag aaatgtttag aaacgctcta 658801 tcaatacata cacagcgtca tgaaaaacag cttttctcgg tcgagtggtt taccgcttgg 658861 gaagatgagg aggattttga gctgtctgcc aaaagagagc tgacacttga tgaattcaca 658921 tctccattgc agctcatttt aaaagacaga gagcttttga gaatcgttca gaaaaaatgg 658981 cagtaaaaaa cccgcccttt agcaggcggg tttttttata aattaaagca ctttcgtcgt 659041 ccaagactcg cagttccacg tttctgtcgc aatatccata taaaagtctg gctcgtggga 659101 aatgagcaga atggagcctt tatattcttt cagggcgcgc ttgagctctt ccttggcatc 659161 ggcatccaag tggtttgtcg gctcatcgag caccagcagg tttgtttctg agttgattag 659221 cttgcacaat ctgactttcg ctttttcgcc tccgcttaat acggagacgc ggctttcgat 659281 atgctttgtc gtcagcccgc attttgccag agcggcacgg atttcatact gcgtataaga 659341 agggaattcg ctccatactt cttcgatgca cgtattgttg tttgtttcct tgacctcttg 659401 ctcgaaatag ccggtataga tgtgctcacc gcgttcaaca gagccttcga gcggctggat 659461 ttcaccaagc aaacttttca gcaatgtcgt ttttccgatc ccattcgcgc cgtaaagggc 659521 gattttttgg ccgcgctcca tgcggaggtt gagcggacgg gacagcgggg aatcgtaacc 659581 gatcacgaga tccttcgttt caaaaatcag cttgcctgac gttctcgccg gcttaaagtg 659641 gaattccggc tttggctttt ctgccgcaag ctcgatcata tccatcttat cgagtttctt 659701 ttggcgggac atcgccatgt ttctcgtgct gacacgcgct ttgttgcggg cgacgaaatc 659761 cttcagctcc gcgacttcct gctgctgctt tttgtaggcc gcttcaagct gctgtttttt 659821 cacctcgtag acttccataa actgatggta gtcgccgaca taacgtgtca gctcttgatt 659881 ttcaacgtga taaatcaggt tgatgacact attcaagaac ggaatatcgt gggaaatcag 659941 gatgaacgcg ttctcgtatt cctgcaggta gcgtttcagc cattcaatat gctgttcatc 660001 aagatagttg gtcggctcat cgagaagcag aatttccggc ttttcaagga gaagcttagc 660061 gagaaggacc tttgtgcgct gtccgccgct caaatcggtg acatctcgct ctaaaccgat 660121 atcgctcaaa ccgagaccgc gggcgatttc ttccaccttg gaatcaatga cataaaaatc 660181 attgtttgtc agcgcgtctt gaatgacgcc gacttcttca agcagcttct cgagctcgtc 660241 gggatcagcc tcgcccattt tgttgtaaat ctcgttcatt tcctcttcca tcgcaaataa 660301 ataatggaat gcgtctttca ggacgtcgcg aatggatttt cctttttcca gcacggtatg 660361 ctgatcaagg tatccgacac ggacattttt tgaccattcg acttttccct catcaggttc 660421 aagctttccg gtaataatat tcatgaaggt tgattttcct tcaccgtttg cgccgatcaa 660481 gccgacgtgc tcgcctttta acaggcggaa ggaaacgtta ttaaaaatgg cccggtcccc 660541 gaaaccgtgg cttaaatcct ttacagataa aatactcatg tttacacctc tatcgttatc 660601 aaacacgcac aatcggcgtg taatattcac ccttttgatt ataaaggagg attcggaatg 660661 ttgaaaggta taggaaagaa aaagaaaaat tgcgttccgg gcgaggtttt gagatactat 660721 ggaatagatt tcaggaattg aggagaacaa aatgacgcaa acttggccat ttttacataa 660781 tgcacaatca tttatacaag agaattggaa tgcttccggc tttcaaaagc caacccctgt 660841 tcaggagcag gcagcccagc tgatcatgga cggaaaggat gtcattgcag aatcgccgac 660901 aggcacaggg aagacgctgg cgtatgcgct gccggtcttg gagcggatca aaccagagca 660961 aaagcatccg caggcggtga ttttagcgcc ttcccgtgag ctggtcatgc agatttttca 661021 ggtgattcag gattggaaag cgggctcaga gctgcgcgcg gcttccttaa tcggcggggc 661081 gaatgtgaag aaacaggtcg aaaagctgaa gaaacatccg catatcatcg tcggcacgcc 661141 aggcagggtg tttgaactga ttaaagcgaa gaaactcaaa atgcatgaag tgaaaacgat 661201 cgtgcttgat gaaacggatc agctcgtcct gccggagcat cgcgaaacga tgaagcaaat 661261 cattaaaaca acattaagag accgccagct tctatgtttt tctgccacgc tcaaaaagga 661321 aacagaggac gtgctccgcg aattggcgca agagcctgag gtgttgaagg tgcagcgaag 661381 caaggcggag gcagggaaag tgaagcatca atacctgatt tgcgaccagc gcgacaaagt 661441 gaagctgctg caaaagctgt caaggcttga aggcatgcag gcactcgtat ttgtgagaga 661501 cattggcaac ctgagtgtat atgcggaaaa actggcatat caccacgttg aactcggcgt 661561 tttgcacagt gaagcgaaaa aaatggagcg agcgaaaatc attgccacat tcgaagacgg 661621 agagtttcct cttttattgg cgactgacat tgccgcacgc ggtttagata ttgaaaacct 661681 gccatacgtg attcatgctg atattccaga tgaagatggc tatgtccaca gatcaggacg 661741 aacaggccgg gccggaaaag aaggcaacgt gctgagcctt gtgacaaaat tggaggaatc 661801 taagctgaaa aaaatggcga agaagcttgg tgttgagctg agtgaagctg tgtatgcagg 661861 cggaaaactg aagacgaaat aaaaagaagg gcgaagagcc ctttttttgt tgtaaaataa 661921 tagaaaagat tttgcgcgga ggtgggaaaa tggcttcaat agacaggttt caagtaatgc 661981 aggagccaga gctgaaaatc cttgaacact ggtttgagaa tgaggatacc agacggagaa 662041 tggatgggat gctgctatta gatgagtggt atgcacgagt aaataaagat aaacacgata 662101 ctgtcatcat ggcgtatgat ggacagctgc cggcagggat ggtcgttatt gagttcggag 662161 aggagcggac atatattgga ttgatcgtca atcctttgta ccggcttaaa gggtatggaa 662221 aacagatact gcaaaagctg atgaccgaac ctgattttac tagcgtgcga gaatgggtgg 662281 catgcattga agaagacaat cgaatcagtt tagcttgctt tcaagcagca ggattcactt 662341 tagaagacac ggaacctgat gaagatggtt ttcttacgct gattcttcgc aactgatctc 662401 atcgaaacac aaaaggaggg caaaaagccc tcccgttttc atcttcattc agctcggatc 662461 actgaccttg atcagctgtt tccctttatt ttctccctta aataaaccga gaaacgcgtc 662521 aggaatgttt tcgaagcctt ctgtgatggt ttcctcgtaa tggagtttac cagccttcag 662581 ccattctgcc agctgttttg ctccctcaga aaaacgatcg gagtagtcgc ttacgataaa 662641 gccttgcatc agcgacttcg ttttaatgag ttttgattgg acacgagggc ccatgtcatc 662701 tgcttcgctt tctgcgttat aggaagaaat ggcgccgcac accggaatgc gggcaaattc 662761 attgagcaga ttcatcaccg cgtctgaaat cggtccgccg acattgtcaa aatacacatc 662821 gacaccgtca ggacaagcgt tttgaagcgc tttttggata tcatccgctg ttttgtaatt 662881 gatggcttcg tcaaactgaa gctcctgttt taaatagtcg attttttcat cagagcccgc 662941 gatgccgacg actcgcgcgc ctttgatttt ggcaatttgc ccgactgttg aaccgacggc 663001 tccggcagct cctgagacaa ccacggtttc gccttccttc gggcgtccga tgtccagcaa 663061 tccgaagtat gctgttaagc cggtcattcc caaaatgccg agataggccg aagcgggagc 663121 aaggcttgta tcaatttttc gcaaggcaga ctcgctcaca gcggaaaatt cctgccagct 663181 gagatttccg atgacgatat cgcctttttt cagatgattc ccgtctgaca caacttcagc 663241 gataacccct ccagaaagcg ctttatccaa ggcgaacggc tcaacatatg acttcgtatc 663301 ctgcatacgg ccgcgcatat aagggtcaac cgatacataa agcgttttga caagcacttc 663361 cccttgcttg ggttcaggaa ccggaatggt ttcaaagcga aagtcttcat gaacaggaat 663421 accttgtgga cgtcttgcta attgaatttg ctgctgagat gctgtcattt tcatcctcct 663481 atcacttggt tgacaccact gtaacatgga caggagagga aatacaaaag gtaagctggc 663541 atacaaaaaa ggttatagat gagcttatgc tttctacaag ctcttttgtt ttaaaagttc 663601 tctttagtca tttatcatta ttagaaaaca gaacagaaaa agagctcctg tacacctagc 663661 taagattggc tagtgtgtat gtcgattctt tttcatattc ttgcaagcat ctgcgagggg 663721 gagcttagtc gttcacattt tgctttcgca tcaatctgca atagcaaagt ctatgcgatt 663781 tttttacatc agcaaagatt tgttcaattt tttcctttta tgccgagttt ttctgaaaca 663841 gataattgat ggtactcaac cattttcttt tggtcaataa agtaatgttt acttattaat 663901 taaacacgcg aaaaagcaaa cgaaaacata attaaatttt atatatttat taaaagctta 663961 tatgtttatt tacctttttt ttgaattgta attgagaaaa tccatatatt gcggacacta 664021 ataaaagaat acctgctgaa acataaacta aacgaactcc aaggaaatct gaaatagccc 664081 ctatagccag aattgaaaac ataaaaatga actgtactaa agaagacctt gcagacatta 664141 tattaattcg agtttgctcg gttgttatgt tctgaataag tgtttcttgt gtaagatctc 664201 ttaatatata agccggcccc ataaagagaa ccaaaattag agctaagtat gaattactta 664261 taaaaccata tattaaagtt aaacttccat atgagacagc gccaattaac ataaaattaa 664321 ttaacttatt ttgaaatctc tccgacagct tatatattat aaatccccct atcatcgaac 664381 ctaaataata tgctccatta ataaatcccc accatgattc tcctttatgc aagacttcgt 664441 taacgaaagc taaagagaca gatcctatcc aaatcattcc tgcccatgac tcaattaaat 664501 ccataataat aattgttcta agtttctttt ggctaaataa ataccgccaa ccacttacta 664561 tactcttatt gggagaattt ttttcacgta tgacagaatt agcgtggcca tgtggtagac 664621 aaaataaaag agaaagaaga gatgtaaaca acaaaaagat agtaagtata atggtatatc 664681 cctcacctaa aaatgcaatt atgagaccac ctaaagacca gcctacaaat tgaaaagttt 664741 ggtccactgt agataataat ccatttgctt ttactcttct atcaggagag attatttccc 664801 ctataattgc actttttaaa ggtgagaacc atccattaaa aaaggaaata cagctaataa 664861 taataaagac taaaatgaga gtttgattag agtaagttct taataaagca tagaacaaac 664921 atattaataa cagcatttgt atcaattgag aaataattat tgtaagaggc agttttaatc 664981 gaattgttat taacggtaat atagcacttc caaaaatacg aaaaataata cttattaatg 665041 tcaccataga ggcgatggtt gtcgaattgg tcattttaaa caaaaacgaa atcactacca 665101 tagtatatag agaaaaacct aaatttgtag tggtctggct aaataaaata gaataataac 665161 ctttactcat atgtatcctc ccttggaata atttttctcg gtaaagagct taaacatatt 665221 taaacacctt aaaacaacaa aagtaaagaa aaaatttcct tgtaaactat ttacttttat 665281 tctatttatt gttattgttt atttaagttc tctgactatt ctatcaatat tcagggaacc 665341 acatatctta ttaaaggggg gaaaaccatg agaaaattaa gaaaaaactg gagaaaatcg 665401 attgttagcc cggttcttta tactaatgaa aaatggtaaa cacttaggga atagcattta 665461 atgctattcc ttatttcaac aaacaaatcg ggaggttatc gtaatttgac tctattaatg 665521 caagatcata aatcaattta caataaagat atagaaatat taattgaagt tgaagaactt 665581 attacttctg ttccagaaaa taaaaaaaat gattttaaga gtttaatcga taatagaatt 665641 atgactctac taaataaaat tcaacaccct gtagcagcgg aaaatgtgtt tgggatgtgt 665701 attgcttatc cgaatactta cataaggtat agattaattg atttcgttga aaaatgggta 665761 ccttatttct ctgctgtaga aactataatc aatctaaccc aggatccgga tgatttagtt 665821 tcttttaaag ctatggatgt ctgtgcaaat cataaaattg aagaatctgt agcatatttg 665881 tcttcgatta ttgatgatgt ccgggagagt ataagctacc ctaaaaaacc tgtgggatta 665941 ggggcccaaa aagtattaag tacattatta gatatattcg gtgttgaaaa acatgaagag 666001 ctagtaatgc taaaaaatta ttttgatcaa aatggtatac ttcctaataa ctttgacttt 666061 gaagaaaaaa ttcctcaaag tctaatagag gaattcgaaa aaacagaaga agatgggatg 666121 attttaattc cgggtggctt ttttgaattc ggtttaaatg aaaatgaaat tcctgacaaa 666181 acatttaatt ggaaagatgc tgttcctaga caaaaagtat ggttacctcc attttttatc 666241 gataagtatc ctgttacaaa taaagattat gatatcttta ccgagttcat agaggaaaat 666301 gggcatatat tctgtcatcc taatgaaccg cagaataaac aacatagaag aaatacatat 666361 tgggatgata ggtatttaga taatcatccc gttacaggta tagattttta tgatgcattt 666421 gcttacgcaa gatataaggg gaaagaattg ccaaccgagt ttcaatggga aaaagctgct 666481 cgaggcgaaa agggtaatgt ctggccttgg ggagataaat ttgatcctgc aaaggttcaa 666541 tatgctggaa gtctttataa tgaacccatt acttctttaa agtcctggag agaaaattta 666601 ttaaaagctc atgctgataa agaattaaat catttaacaa gtgatatttt tgaacaaaat 666661 ggtgaaagtc cctatggagt atgcggtatg atcggcggaa catgggagtg gactagaagt 666721 gagcttaaaa caaagagagc tttccaccct atttttgaga atgtaccatt taatagtgtt 666781 aactcatttg ccgttcttaa aggaggatca ttcttctctc atccaggctt aatgttccct 666841 tcttttagag caaaagatat tcctttctgt cgacacaatg aaatggggat tagatgcgta 666901 aagaatattc cagtatataa aattagagaa tcaattaatg ggccaattac taataaagca 666961 atttattaat cattctaggt tagagacttg ataaaagtat actaacattg tgtagtaatg 667021 ttcagcttgt agaaaaaaca atgttttttc tacaagattt tattttaaat gcttttcaaa 667081 attatcaggg attgagaatc agaaaaagag ccattaagct cgatcttagc taggtattac 667141 gatcttctgt atattattgt gagaaatata gaagattcag ttagttagca tttcgatttt 667201 aagctgagcc tgcaatagca aagcatctgt tttgattatt ctttttctga tacataagct 667261 aattttgtcg cttttctttt ttgtcttttc acgcatttcg aggatgactt actataattc 667321 tttcagcttt tctatgtgtt aagattcgaa tagatgaaat aactttaaca agttggtcaa 667381 taagaacaga tttaacttta tgttaaaaga gtatctcgta tagaacataa gaagaatgac 667441 gagtttttta agattatcat caattatgtg agaataaaat attataaggg aaaatgaagg 667501 ctgtcacgtt tctcgacagc cctagggaat tcctctcctt ttcatttcgc ccgtaatttc 667561 gggcacagtc ccgtcggcag gcacattggc ttctggtcga tcgggcttct catgatgcag 667621 cattccaagc cgaagacttc acggaaaaat ggctgggtga acacatcttc cggtgttccg 667681 gcgttgtata tttttccgtc cagcacactg atcagatagt cagcatattg agcggcttgg 667741 tttaaatcat ggagcaccat gacaacggtg cggccatggt cgcggttcag ctttttcagc 667801 agttcaagca cttcaatctg atgtgagatg tctaaatacg tggtcggctc atcaagcaaa 667861 agcaaatcag tgccttgcgc aagtgccatg gaaatccagg ctctttgtct ttggccgcct 667921 gagagggcat caagtgtccg atccttcagt tcaatcatgc ccgttgcttc cagcgcccac 667981 tctaccatgt catgatcctc ttgggtatgc ttggataaca gctttttgtg aggatgtctg 668041 ccaaaatagc ataattcctc taccgtcaat ccttcaggag cctgaggaga ttgtggaaga 668101 atggccagtt tttttgcgac ttcttttgat ggctggcggt ggatgtcttt tccttctagt 668161 agcactgtac cgctttttgg ggccatcagc ctggcgagcg atttgaggat tgttgattta 668221 ccgcagccat tagcgccgat gagcgcagtg atttttcctt cttctatctt taagtcgact 668281 ccgtcaataa tcactgtact gtcatatgaa agagtgagct ggtctgcagc cagttttccc 668341 atggtatcct ctccctactg tttcctcgct tcgaatttca ataaatataa gaaataaggc 668401 gcgccgatca cggctgtcag tattccggca ggtatttcaa ccggaggcat gatgccgcgc 668461 cctaacgtat ctgcaattaa taatataata gcaccaatca atgccgatgc aggcagtaaa 668521 tatttagctt tttctccggt aagccgtctg gcgatatgcg gagcaagcaa gccgataaaa 668581 ccgattgagc cgacgacggc tacacagctt cccgccagcg ccaccgcggt gaaaatcagg 668641 atgaatctca gccggtttgc gttttctccg agaccctgtg caagctcatc cccgagtgac 668701 ataagatcca gcttcggtat gagtatgcag acgatcggaa aaagaatcaa aagccatggc 668761 gcaagcagct tgacttcttc ccagtttctt ccccagaggc ttcctgtcag ccaaatgagt 668821 gcagcattca cgtcgcctgg aaacttgacc atcatatatt gcattccggc gtggcagacc 668881 gcgcctaaag caatgcctga taaagccagt gaagagggct gaatgctctt ttttcgggct 668941 atcattaata atagtacagc aataatggcg gctccggcaa atgcggagaa cggaagcacg 669001 tataccggcg actcaggaaa gatgagaatc acagccatcg ccgcaagtcc ggagcctttt 669061 gaaatgccga caacgtccgg ggaagcgagc ggatttcgga tcacaccctg taaaatcgct 669121 ccggcagcgg caagtccagc acctgccaaa atcgctaata taatgcgggg aaggcgatat 669181 tgctggatga taaattcaaa ggaatgatcc agtcccagca gattcgtcac taccgcatca 669241 ggtgaaatgt ataatgcacc gattccaatg ctgatgacgg acagaacgat taaaatcacg 669301 gccaatatga gtatcgccag taaggggcgt ttttgttttc tggttgtttt cttcatttca 669361 ggtttcgccc tttccttgcc aaatataaga aaaacggcgt tccgataatc gcggtgacaa 669421 tgccgaccgg tgattcataa ggaaatgcaa tccatctggc cagaacatct gcgtacacca 669481 gcaaaatggc accgaacagt gccgaaaacg gaagcacgta ttgataatgt tctccgatca 669541 gcttgcggac aatatgcggg acgagcagcc cgacaaagcc aatcggcccg gcgacggcta 669601 cggaagcgcc ggaaagaatt aaaataatca aactgatcag aatcctgatg ccgttcatat 669661 tttgtccaag cccttttgct gtttcgtctc cgagaccgag aacagaaaca gaaccggaaa 669721 atacgagggc aagcccgatg ccaatgacag aaaaaggagc gatggttatg acgtcctgcc 669781 agttgctgcc gtcgattgcg cctgtcatcc agtacagaac atcctcacct gactcattta 669841 aaataatgat ggcctgtgtc atagaggaga ggaacaagtg cacggccatt cctgacagcg 669901 ccagcttgac aggcgtcatt ccgccggatg aggcaatcat atacacaatc gcgccgcctg 669961 ctgccgcacc cgcaaaagcg aatataacag atgaataggg cgatgccggc agaatgacga 670021 gagaagcaac aacaaaaagc gatgcacccg cattcacacc gaaaatttgg ggtgaagcca 670081 gaggatttct ggtcatagcc tgcatcagcg cccctgctac agctaggctg gcgccgacaa 670141 aaacgccgat taatgtgcgg ggaaggcgaa gagtagagat gatgagctgt tcctttgaac 670201 cgtcccatac aaaaagatat ttcaatgaat ctatgatgct gatgtctgag gctcctactg 670261 aaagattcag cccaagccca aatataaaaa taatcagtgc aatgataaac atcatcagtc 670321 ttgatgatga gcgccgtttg gctgaatgat acaacagtct cacttcctta ctgcgtctgg 670381 ttgcaaaaac gaagaagcaa ggattcccct cgcttctcat ttgtcctatt tattatacac 670441 ttttttaagc acatctttgg cgcttgtttc actagacttg atgcctctga atcttgtcca 670501 agtgtcacgg tccgcatcat agacttgtcc atttttcacc gctttgagat ttttccagag 670561 cgggttcgtt ttccactcat ctacaatggt tttgccttcg ttggctgaga tgaacaaaat 670621 atcaggatcg attttgctca attgctcaag gctgacctct tgataggcgt tatctgactt 670681 cacagcgtgt gtaaagccta gcattttaaa gatttctccg tcataggatg atgatgtatg 670741 aagctggaag gaatccgctc ttgcaacgcc gagaacgatg ttgcggtttt catctttcgg 670801 aagttcggct tttagatcgt tgatgacttt tttgtgctcg gcaagctttt cttttccttc 670861 atcttcttta tttaatgctt tagcaatggt cgtaaagctg tcgatcgttt cgtcatatgt 670921 cgcttcacgg ctttttaatt caatcgtcgg ggcgattttt ttcagctgtt tataaatgtt 670981 tttatggcgc tcagcgtcag cgatgattaa atcaggcttc aaggaactga tgacctcaag 671041 attgggttcg ctgcgtgtgc ctacagatgt gtaatcaatg gagctgccga caagcttttt 671101 aatcatatct tttttgttgt catctgcgat gcccaccggc gtaatgccga gattgtgaac 671161 ggcatccaag aatgaaagct caagcacaac cacccgctta ggtgtgccgc ttactgtcgt 671221 ttttccttct tcgtcatgga tcactctgga atccttagac tcgcttttgc cgcttccgtt 671281 gttattctgg cttgatgaac agccggatac aatgaggcag gcgagcaata aaacactcat 671341 gatggcaatc aacttgttag aataggtgcg catgtcattc ttcctttttt cagatttagt 671401 aatgagaatc attatcacat gtaacactat aatagcatgg cttatcatgt caatattttt 671461 ttagtaaaga aagctgcgtt tttactgctt tctcatgaaa gcatcatcag acacaaataa 671521 gtggtatgca gcgttaccgt gtcttcgaga caaaaacgca tgggcgttgg ctttagaggt 671581 ttcgaacata tcagcagtga cataaggaag gagagtgctg agataaccgg acaatttctt 671641 ttctatttca tctgttagtg caaattcaat gtcgccgata ttcatgataa tcgagaaaac 671701 aaagtcgata tcgatatgaa aatgttcctc ggcaaaaacc gcaagctcgt gaattcctgg 671761 tgaacatccg gcacgcttat ggaaaatctg tttgactaaa tcactcacaa tccaagcatt 671821 gtattgctgt tctggtgaaa agtattgcat tagacatacc tcctgctcgt acggataaag 671881 gcagcgtttc atggtcgtgt gctccgtgca gcggcttctc cttaattttg atttttctga 671941 aaataggtcc cgttcctatc actttaccat ggacggaaaa caaatagcta ctaccattcc 672001 tcctgttttt ctcttcaatg ttctggaatc tgtttcaggt acagacgatc gggtatgaaa 672061 gaaatataga aaacatgaag gaggaatatc gacatgaaac cagttgtaaa agagtataca 672121 aatgacgaac agctcatgaa agatgtagag gaattgcaga aaatgggtgt tgcgaaagag 672181 gatgtatacg tcttagctca cgacgatgac agaacggaac gcctggctga caacacgaac 672241 gccaacacga tcggagccaa agaaacaggt ttcaagcacg cggtgggaaa tatcttcaat 672301 aaaaaaggag acgagctccg caataaaatt cacgaaatcg gtttttctga agatgaagcc 672361 gctcaatttg aaaaacgctt agatgaagga aaagtgcttc tctttgtgac agataacgaa 672421 aaagtgaaag cttgggcata aagcaaggaa aaaaccaaaa ggccaatgtc ggccttttgg 672481 tttttttgcg gtctttgcgg tgggattttg cagaatgccg caataggata gcggaacatt 672541 ttcggttctg aatgtccctc aatttgctat tatatttttg tgataaattg gaataaaatc 672601 tcacaaaata gaaaatgggg gtacatagtg gatgaaaaaa gtgatgttag ctacggcttt 672661 gtttttagga ttgactccag ctggcgcgaa cgcagctgat ttaggccacc agacgttggg 672721 atccaatgat ggctggggcg cgtactcgac cggcacgaca ggcggatcaa aagcatcctc 672781 ctcaaatgtg tataccgtca gcaacagaaa ccagcttgtc tcggcattag ggaaggaaac 672841 gaacacaacg ccaaaaatca tttatatcaa gggaacgatt gacatgaacg tggatgacaa 672901 tctgaagccg cttggcctaa atgactataa agatccggag tatgatttgg acaaatattt 672961 gaaagcctat gatcctagca catggggcaa aaaagagccg tcgggaacac aagaagaagc 673021 gagagcacgc tctcagaaaa accaaaaagc acgggtcatg gtggatatcc ctgcaaacac 673081 gacgatcgtc ggttcaggga ctaacgctaa agtcgtggga ggaaacttcc aaatcaagag 673141 tgataacgtc attattcgca acattgaatt ccaggatgcc tatgactatt ttccgcaatg 673201 ggatccgact gacggaagct cagggaactg gaactcacaa tacgacaaca tcacgataaa 673261 cggcggcaca cacatctgga ttgatcactg tacatttaat gacggttcgc gtccggacag 673321 cacatcaccg aaatattatg gaagaaaata tcagcaccat gacggccaaa cggatgcttc 673381 caacggtgct aactatatca cgatgtccta caactattat cacgatcatg ataaaagctc 673441 cattttcgga tcaagtgaca gcaaaacctc cgatgacggc aaattaaaaa ttacgctgca 673501 tcataaccgc tataaaaata ttgtccagcg cgcgccgaga gtccgcttcg ggcaagtgca 673561 cgtatacaac aactattatg aaggaagcac aagctcttca agttatcctt ttagctatgc 673621 atggggaatc ggaaagtcat ctaaaatcta tgcccaaaac aatgtcattg acgtaccggg 673681 actgtcagct gctaaaacga tcagcgtatt cagcggggga acggctttat atgactccgg 673741 cacgttgctg aacggcacac agatcaacgc atcggctgca aacgggctga gctcttctgt 673801 cggctggacg ccgtctctgc atggatcgat tgatgcttct gctaatgtga aatcaaatgt 673861 tataaatcaa gcgggtgcgg gtaaattaaa ttaagaaagt gaaaaacaca aagggtgcta 673921 acctttgtgt tttttaatta attaaaatgt ttattaactt agttaaggag tagaatggaa 673981 aaggggatcg gaaaacaagt atataggagg agacctattt atggcttcag aaaaagacgc 674041 aggaaaacag tcagcagtaa agcttgttcc attgcttatt actgtcgctg tgggactaat 674101 catctggttt attcccgctc cgtccggact tgaacctaaa gcttggcatt tgtttgcgat 674161 ttttgtcgca acaattatcg gctttatctc caagcccttg ccaatgggtg caattgcaat 674221 ttttgcattg gcggttactg cactaactgg aacactatca attgaggata cattaagcgg 674281 attcgggaat aagaccattt ggcttatcgt tatcgcattc tttatttccc ggggatttat 674341 caaaaccggt ctcggtgcga gaatttcgta tgtattcgtt cagaaattcg gaaaaaaaac 674401 ccttggactt tcttattcac tgctattcag tgatttaata ctttcacctg ctattccaag 674461 taatacggcg cgtgcaggag gcattatatt tcctattatc agatcattat ccgaaacatt 674521 cggatcaagc ccggcaaatg gaacagagag aaaaatcggt gcattcttat taaaaaccgg 674581 ttttcagggg aatctgatca catctgctat gttcctgaca gcgatggcgg cgaacccgct 674641 gattgccaag ctggcccatg atgtcgcagg ggtggactta acatggacaa gctgggcaat 674701 tgccgcgatt gtaccgggac ttgtaagctt aatcatcacg ccgcttgtga tttacaaact 674761 gtatccgccg gaaatcaaag aaacaccgga tgcggcgaaa atcgcaacag aaaaactgaa 674821 agaaatggga ccgttcaaaa aatcggagct ttccatggtt atcgtgtttc ttttggtgct 674881 tgtgctgtgg atttttggcg gcagcttcaa catcgacgct accacaaccg cattgatcgg 674941 tttggccgtt ctcttattat cacaagttct gacttgggat gatatcaaga aagaacaggg 675001 cgcttgggat acgctcactt ggtttgcggc gcttgtcatg ctcgccaact tcttgaatga 675061 attaggcatg gtgtcttggt tcagtaatgc catgaaatca tccgtatcag ggttctcttg 675121 gattgtggca ttcatcattt taattgttgt gtattattac tctcactatt tctttgcaag 675181 tgcgacagcc cacatcagtg cgatgtattc agcatttttg gctgtcgtcg tggcagcggg 675241 cgcaccgccg cttttagcag cgctgagcct cgcgttcatc agcaacctgt tcgggtcaac 675301 gactcactac ggttctggag cggctccggt cttcttcgga gcaggctaca tcccgcaagg 675361 caaatggtgg tccatcggat ttatcctgtc gattgttcat atcatcgtat ggcttgtgat 675421 cggcggatta tggtggaaag tactaggaat atggtagaaa gaaaaaggca gacgcggtct 675481 gccttttttt attttcactc cttcgtaaga aaatggattt tgaaaaatga gaaaattccc 675541 tgtgaaaaat ggtatgatct aggtagaaag gacggctggt gctgtggtga aaaagcggtt 675601 ccatttttcc ctgcaaacaa aaataatggg gctgattgcg gctctgctgg tctttgtcat 675661 tggtgtgctg accattacgt tagccgttca gcatacacag ggagaacgga gacaggcaga 675721 gcagctggcg gttcaaacgg cgagaaccat ttcctatatg ccgccggtta aagagctcat 675781 tgagagaaaa gacggacatg cggctcagac gcaagaggtc attgaacaaa tgaaagaaca 675841 gactggtgcg tttgccattt atgttttgaa cgaaaaagga gacattcgca gcgcctctgg 675901 aaaaagcgga ttaaagaaac tggagcgcag cagagaaatt ttgtttggcg gttcgcatgt 675961 ttctgaaaca aaagcggatg gacgaagagt gatcagaggg agcgcgccga ttataaaaga 676021 acagaaggga tacagccaag tgatcggcag cgtgtctgtt gattttctgc aaacggagac 676081 agagcaaagc atcaaaaagc atttgagaaa tttgagtgtg attgctgtgc ttgtactgct 676141 gctcggattt attggcgccg ccgtgctggc gaaaagcatc agaaaggata cgctcgggct 676201 tgaaccgcat gagatcgcgg ctctatatcg tgagaggaac gcaatgcttt tcgcgattcg 676261 agaagggatt attgccacca atcgtgaagg cgtcgtcacc atgatgaacg tatcggcggc 676321 cgagatgctg aagctgcccg agcctgtgat ccatcttcct atagatgacg tcatgccggg 676381 agcagggctg atgtctgtgc ttgaaaaagg agaaatgctg ccgaaccagg aagtaagcgt 676441 caacgatcaa gtgtttatta tcaatacgaa agtgatgaat caaggcgggc aggcgtatgg 676501 gattgtcgtc agcttcaggg agaaaacaga gctgaagaag ctgatcgaca cattgacaga 676561 ggttcgcaaa tattcagagg atctcagggc gcagactcat gaattttcaa ataagcttta 676621 tgcgatttta gggctgcttg agcttgggga gtatgatgaa gccattgatc tgattaaaga 676681 ggaatatgcg atacaaaatg aacagcatga tcttttattc cataacatcc attcgcagca 676741 ggtgcaggcc attttgttag ggaaaataag caaggcatcg gaaaagaagg tcaagctggt 676801 gattgatgag aacagctcac tcgcgcctct tcctgcgcat atcggcttgt cccatcttat 676861 tacgattatt ggcaatttaa ttgataacgc tttcgaagct gtagcggagc aaagcgtgaa 676921 ggaagttttg ttttttatca cggatatggg ccatgacatt gtcattgaag tatcagacac 676981 agggcccggt gtgccgccag agaaaataga agctgtgttt gagagaggct attcttcaaa 677041 ggggatgagg agaggctacg gtctggccaa tgtgaaagac tcagtgcgtg aactgggcgg 677101 ctggatcgaa ctggcgaatc aaaaaactgg cggggcggta ttcactgtat ttataccgaa 677161 ggagaaacaa agggggaatc catttgattc acatcgcgat tgcggaggat gattttcgag 677221 ttgcgcaaat ccatgagaga ttgattaaac agcttgatgg attcaagatt atcggcaagg 677281 cggctaacgc aaaagagaca ttggcgcttt tgaaggaaca caaggctgat ttgcttctgc 677341 tggatattta tatgccggac gagcttggga ccgcgttgat tcctgatata cgaagccgat 677401 ttcctgaagt ggacattatg attatcacag cggcaacaga aacccgtcat ttgcaggaag 677461 cgctaagggc gggaattgcc cactatttga tcaaacccgt aacagctgac aagttcaggc 677521 aggtgctgct tcagtataaa gaaaaaagga agctgctcat gtctcagccg gaggtcagcc 677581 aatccatgat cgaccatatt tttgggaacg gtgtgaagac agctttgccg gcagaggatt 677641 tgccgactgg cattaattcg attacactgc gaaaaattaa ggaagcgctt cagactgcgt 677701 cagaaggatt gacagcggag gaacttgggg aaaaaatggg ggcgtcacga acaactgccc 677761 gccgttatgc cgagtacctt gtgtcaaagg aagaagcaag agccgagctt gaatacggga 677821 ttatcggcag gccggagaga aaatattatt tggcggcgga ttagatatga aaaaatctat 677881 aatcctattg aatattctat tgatctttat gcagggtgat atcaggcagg cggctgcgcc 677941 gcgcctgccg gacgggccga tagaaattgt cgtccctgcc gaaccttctg gcggctggga 678001 tgtcacagcg caggcgatcc aatcagtttt gaggcagaag cagatcgtga aggatgatgt 678061 tcatatcgtc tataaatccg gcggcggggg agagaaaggc tggaaatatg tcaacaaaag 678121 cagcaaacaa accatcagca tgacgtccag cctaatattg agcaatgatc ttctcgggca 678181 aagcaaatta aaaatgtccg attttacgcc gctcgccatt ctctccaagg aatggcagac 678241 ggttgcattg ccaaaaggat cagcgttaac aaatggcaag gatgtgctga atgagatcaa 678301 catgcatccc ggcaaggtga gaatcggctt tgccccgggg tttggcaatg atgatcagct 678361 ctcgttcgtc agagcggcag atatgtacgg cattgacccg tttgacattc aattctcaca 678421 gtatgacagc agcgaacagc tcattcaggc gctgatcaga catgagatag aagcggcttc 678481 catgacactt tctgaagcga aaccatatga acgaaacggc gatatcacgt tagccgctgt 678541 aacgtctgat aaaagacttc ccggttttcc aaatgtaccg acgtggaagg agcagggaat 678601 cccgtttgtt ttttctcatt ggagagggat tttgggcccg aaaaatatgt ctgaggaaga 678661 gatttcttac tgggatcaag cgctaaagaa ggtcacctcc tcacctgaat ggaagcggaa 678721 aataaacgaa caggactggg aaagctttta tttaaacagc agggaaacga aacggttttt 678781 agaagagcaa tctgcttttt atcaaagcat catgacagga aattaaaatc ccgacatccc 678841 gggatttttt tcatgccgaa aattgatcaa aaagaacaaa acggttttaa aaaattaaaa 678901 atacaaaaaa accaaattat ttacttgcgg ttggttttcc catacgatgg caaaaaggca 678961 agacaaaaag gggagtaagg gagaaaaaaa tgtaagcgga ttcatttaag ggggaatgga 679021 tgtgttagca atcttaggct ttctcatgat gcttgtgttt atggcattga tcatgacaaa 679081 acggctttct gttttaacag cattagtttt gacgccgatt gtgtttgcgc ttatcgccgg 679141 atttggattt actgaagttg gggacatgat gatttcgggg attcagcaag tcgcgccgac 679201 tgcggtcatg attatgtttg cgatcttata ttttggaatt atgattgata caggcctgtt 679261 tgatccaatg gttggcaaaa ttttaagcat ggtcaaagga gaccctttaa aaattgttgt 679321 cgggacagcg gttcttacaa tgctcgtcgc cttggacgga gatggctcga caacgtacat 679381 gattacgaca agcgccatgc ttccgctcta tttgctgcta ggcatccggc caattatctt 679441 ggcaggaatc gcgggagtcg gcatgggaat catgaacacg attccatggg gaggtgcgac 679501 gccgagggcg gcgagtgcgc tgggggttga tccagctgag cttacagggc cgatgattcc 679561 tgtcattgca agcgggatgc tttgtatggt ggcagttgcg tatgtgcttg gaaaagcgga 679621 acgaaagcgc cttggtgtga ttgaactgaa acagccagcc aatgccaatg aaccggctgc 679681 tgcggttgaa gatgagtgga agcggccgaa gctttggtgg ttcaatttat tgttaacgct 679741 ttctttaata ggatgtttag tatcgggtaa agtcagttta accgtactgt ttgtcattgc 679801 gttttgtatt gcgctgattg tgaattatcc caatctcgag catcagagac agcgcatcgc 679861 ggcgcattcc agcaacgtgc tggctatcgg ttcaatgatt tttgctgcgg gggtgttcac 679921 ggggattttg acaggcacga aaatggttga tgaaatggcg atctcgctcg tgtccatgat 679981 accggaacaa atgggcggat tgatcccggc gattgttgcc ttaacaagcg gcattttcac 680041 atttttgatg ccgaatgacg cgtatttcta cggggtgctg ccgattttat cagaaacagc 680101 tgtcgcatac ggtgtggata aagtggaaat tgccagagcc tctattatcg gccagccgat 680161 tcatatgctg agtccgcttg tgccatccac tcatttgctt gtcggactcg tcggagtttc 680221 tattgatgac catcaaaaat tcgcattgaa atgggcggtt ctcgcagtga tcgtcatgac 680281 ggctatcgct ctattgatcg gtgcgatctc tatttccgta tgataattca ggcgtaatga 680341 cacacactaa cggcatacaa cattccggag gtgtcattat gagtgatcct tatatgccgc 680401 tgacttcagt cagaagcgga gcggggttcg aagcggcaaa aggggtgcac ggcctgactg 680461 tgcaaattgc gaatgtctat tttattcagc tgccttctga acctcactca tttgttttaa 680521 ttgatgccgg catgccccaa tcagccggcg tgattgtcaa tgaagccaaa caaagattcg 680581 gtgaagggtt tcagctgaag gcgattatcc tcacacacgg gcactttgac catattgggg 680641 caatcgaaga gatccttgag cattgggatg tgcctgttta tatccattct cgggaaatgc 680701 cttatgtaac aggtaaagag gattatcctc cggctcgtcc tgacagcaag agcgggctgg 680761 tcgctaagct gtcgccgctg tttccgcggc actctatcga tatttcctca catgtccagg 680821 cactgccgga agacggttca gttccttttc ttgacgagtg gatgtggatc gcgacaccag 680881 gacacacgcc gggccatatt tcgttattcc gcgatgacgg ccgcgtgctt gtggcaggtg 680941 atgctgttat tacagtggaa caggagaaaa tggctgacgt cttgatacaa aaacaggagc 681001 ttcacgggcc gccggcttat ttcacgcctg acacagagac ggccgctgag tccattctaa 681061 agctggccgg tcttgaaccg gaagcgttat tgaccgggca cggcataccg atgaccggca 681121 aaaactttcg aagtgactta actgaattgg caaatcggtt atcgtctatt tgacacccgc 681181 accacgcggg tgttttttat tgttttccag gaagttgcag aaaaatcatt tgtcttgccg 681241 cttaaaaacg atacaatgaa aagcatgaag tgatgtgaag gggagagttt gttggaagaa 681301 aaagaaatac tctggaacga agcgaaagcg tttattgccg catgctatca ggaattggga 681361 aaggaggagg aagtgaaaga ccgtctcgcg gacattaaaa gtgaaattga cctgaccgga 681421 agctatgtac atacgaagga agagctggag cacggagcga aaatggcttg gagaaacagc 681481 aaccgctgca tcggcagatt gttctggaat tcgctgaatg ttatcgacag acgagacgtc 681541 cggacgaagg aggaagtgcg tgatgccctc tttcaccata ttgaaaccgc caccaataac 681601 gggaaaatca gaccgaccat tacgattttc cctccggaag agaagggtga aaagcaagtc 681661 gagatctgga atcatcagct gatccggtac gctggatatg agtcagacgg agaaagaatc 681721 ggcgacccgg cttcctgttc cctgacagca gcctgcgaag agctcggctg gcgcggagag 681781 cgaacggatt ttgacctgct gccgctcatt tttcgcatga aaggggacga gcagcctgtc 681841 tggtatgagc tgccgcgttc acttgtgatt gaggttccaa tcacacatcc ggacatcgag 681901 gcgttttctg atttggagct gaagtggtac ggcgtgccta ttatttctga tatgaagctt 681961 gaggtcgggg gcattcatta taatgccgcg ccatttaacg gctggtatat gggcacggag 682021 atcggagcga gaaacctcgc agatgaaaag cggtacgaca agctcaaaaa agtagcgtcc 682081 gtgatcggca tcgccgctga ttacaatacg gatttatgga aggatcaagc gctagttgaa 682141 ttgaataaag ctgtgctgca ctcgtataaa aagcagggtg tcagcatcgt tgaccatcat 682201 acagcggcaa gccagtttaa acggtttgaa gaacaggagg aagaagcggg cagaaagctg 682261 acgggggact ggacgtggct gattccgcca atttcacccg ctgccactca tatcttccac 682321 cgctcctatg ataactcaat cgttaagccg aactattttt atcaagataa gccttatgag 682381 taaacaatag aaaatcgatg atggccttca aggctgcggg attcagtcac agagatgtcg 682441 gtaacctttg agaaagggct tccgttcttt acagcctcaa caaacgattg cagggcgttt 682501 tccggaccct ctgccaaaat ctcgacacgc ccgtcatcac ggtttttgac ccagccggcc 682561 agttttcgct tatcagcttc catttgaaca aaatagcgaa agcccacacc ttgaacccgg 682621 ccgtctacaa tgattcggta ttgaagcatg taaaaaccac cttttctttt tatgataatc 682681 aatcatttta caacctgtaa aggggatgtg tttgtatgaa acaagagcgc tattcagttc 682741 tttctcttaa tctgggaaaa ccgcagacgc ttgaatatga cggaaagaaa atcgaaaccg 682801 gcatcatgaa gcggccggct aaatcagccg tcatgctgta tcgggagaat tttgaaggag 682861 acggacaggc ggacctcgtc aaccacggcg gacctgataa ggctgtctgt gtctacccgg 682921 cggagcatta tccgttttgg gaagagttcc tctcaagacc gctgtcaaat gccgcatttg 682981 gagaaaatct gacggtcgcg ggcctgactg aggagaatgt ttgcatcggg gatgtgttca 683041 gacttgatga agctgttgtt caggtcagcc agccgcgcca gccgtgtgta aagctggcga 683101 aaaagtttgg tgtaaaagaa atggtgctga aggtccagca aaccggctat acagggtttt 683161 attttcgcgt gctggaggag ggcagggtgt ctcccggcgc gaaccttgaa ttgctgtcca 683221 gaggagagaa aggcatatcc gtccagttcg cgaaccgcat caactaccat gatgcaaaaa 683281 atctcaccgc cattgaacgg attttaagtg aggctgcact atcggaaagc tggagagcgt 683341 cctttatgaa aaaaaaggac aggctgctgc cggttgaata gaaaaaagcc gcgcatatca 683401 acgtgcgcgg ctttgccata tttaagattg ttttttcttt gattcaagca ggttggcaag 683461 aaaataggtt ttatagcttt gaagctttct tccttcatgg tgcgtgatcc cctgcttttt 683521 tagttctgcc acataccagc ctttactgcc gtaatgcatg tcagaaaact cctttcccta 683581 tctgatttcg aaacgattgg cattgtaaca tctataaaaa gatgctgaaa agagatgcgg 683641 ggaaaactga gcctttcgca ctagatgtac gaatgttctt ctgaatgtat atgcggagca 683701 aaagccgaat atgatttaat ggccggttag tttgatcatg acaacgccaa atgtcataat 683761 ggcgaaaaca atgccgatat atgtgagcat cccgtttttt ttcttaacgc cgtaaacggt 683821 cataatgatg ccttcaatga aaaaaatgat gccgaaaata ataaaccaca tgcagataaa 683881 ggctcctttc acagacataa tagtagtgta gcatatctga aagagccggg ctgtgacaat 683941 atcaagaaag ccgggcgcat atcgcccggc tcatgtttta ttgtttatca accaatttga 684001 ccagaagctg tgccaaatgt tctttctcat cttcgtctgc aacgctccaa agctcttgca 684061 gcagcatttc ttcaccgttt tgcggctctt catgctttgc gaggtagtct cccaggatcg 684121 cagcgctttt tacaagcttg ccgtcatcca atcccagctt tttgcctcgg ttgacttgtt 684181 ttttcaggta gcctttaaat tcctcaaagt cttttaaaat gtcttctttt attgtgccat 684241 gcatcgcgtt catttcgttt tcaatttgga ttttttcttg atctctgttc attgcaagac 684301 ctcctcgtac agaataatga tgctttacct gcaattggag gaggttaaac ctgccggaag 684361 cccggaatgt gttttacagt ttcgtcagga taatcggttc atcttttgtg atgacgatcg 684421 tgtgttcaac ttgggcaacc atgcttttat ccggcgtctt gaacgtccag ccgtctccag 684481 cttcaacaat cgtttctgct ttcgttgaaa taaacggttc aagcgcgatg actgtgccat 684541 ttttgaacag cgcattatca aacggatcat aatagttcat gatgtggttc ggcgcttcat 684601 gcaggcttcg gccgattccg tggccggtca gggttttgat gacggtaaag ccttgagagc 684661 gtgcttcatg ataaacggct cttccgatct ggttttggcg cttgcccgct tttgcctgct 684721 gaagcccctt ttgaaaagcg ttttccgcgc attggcaaag cttatgaagg cgttcttctc 684781 cttcaccgag cacaaatgag atgcctgtgt cggaatagaa gccgccaaat tcagcggaga 684841 tgtcgatgtt gacaaggtcc cctgctttta aaattttgga tgtgcttggt atgccgtgag 684901 ccacttcatc atttacgctg atacatgtca cacctggaaa atcgtattcc ttctcaggag 684961 ctgaaacggc gccgtgctca tcaagcacag cttttccgat aaggtcaagg tcttttgtgc 685021 tcatgccggg ctctgccttc cgcttcattt cttcacgcgc aagcgcgacg attcttccga 685081 tttttttcag gccttctaat tcttgatcgt ttgttacaat catctgtcat tcccgctttc 685141 tttttaaata atctagatta agcttaccac aactgtctta aaaataggaa acacacggac 685201 ctgggaaaaa agaaataccc ccgggaaaat tggtatagat cactagatat cttatatggt 685261 atatttgaaa aaaaagggta tgagggggat gggtatgctt tcatttttac aaaaactcgg 685321 gaagtcattt atgctcccga ttgcggttct gcctgcggtt ggaattatcc ttgcgcttgg 685381 cagagaggat gtatttaata tcccgtttgt ctatcaggcg gggacggcgg tttttgatca 685441 tctgccgctt atttttgcga tcggtattgc catcggcatt tcaaaagaca gcaatggggc 685501 agcgggttta tcaggggcga tatcgtatct gatgcttgac gcggcaacaa agacaattga 685561 taaaacaaat aacatggcgg tgtttggggg aattattgcc ggtttaattg ccggttacac 685621 ctataaccgc ttcaaggata ccaagctgcc tgaatatctc gggttcttca gtggcagacg 685681 gcttgtgccg attttaacag ccattattac gatcatttta gcgggcatat tcggagtggt 685741 ctggccgccg attcaatcgt gtatcaactc gtttggagag tggatgctcg ggctcggcgg 685801 catcggggca ggcatattcg gcctattcaa caggctgtta attccgcttg gccttcacca 685861 tgtgctgaac aatattttct ggttccaatt cggagaatat aacggagtga caggggattt 685921 ggcgcgcttt ttcgcgaaag atccgactgc gggcacatat atgaccggat ttttcccaat 685981 catgatgttc ggtcttccgg cggcgtgtct ggctatggtt gtgactgcga agccgtctaa 686041 acggaaagcg acggctggaa tgatgattgg atttgcttta acggcgttta tcacagggat 686101 tacggagccg attgagtttg catttatgtt tttatctccg cttttatacg ctgttcacgc 686161 ggtcttaacc gggttatctt tatttatcgt caactggctc ggcatccgct caggcttctc 686221 tttttcagcc ggagctatcg attatgtgct cagctatgga atcgcggaaa aaccgctgct 686281 tctgcttttg gtaggtatat gctatgcggc agtatacttt atcgtgtttt atgtactgat 686341 taaggctttg aatttaaaaa cgcctggacg ggaagacgat gatgtggatg aagtgctgga 686401 tgaaaatact gttcaggatg taaatgaaaa catcatgctg aaagggctcg gcggaaaaga 686461 aaaccttcaa accattgatc attgcgccac aaggctgcga ctgactgtga aggataccgc 686521 tttggtggat gaagcactgc taaagaaagc aggcgcaaaa ggggttgtca aatcgggcgg 686581 gcaatcggtt caagtcatta ttggcccgaa tgtggaattt gcagctgagg aattgagggc 686641 tgctgtcaaa taaaaaagcg gagagggcaa cctctccgct ttttcttatt tatcttcgtt 686701 atcctttgac gtttcggaag aatcttcgtc atgttttgtg taatcataat cagaaggatt 686761 caccttctta aaacctttcg gctcgtagaa ccgcagcagg tctccgttta tgattttatc 686821 ggacatttca agttccttct tgacgagtga gtcttctgac ttgtcgactt cggattcatc 686881 gagttctttt ccggttttcg tgtcgtaata cttaccggat attttcgtgt acttcggtga 686941 aataaagtct ccgtttcgga acggaatcac ttcacggtgt tctttcgata aaatatcaga 687001 accggacatc agatagtcct tcgtatccac tccgagcaga tgcagaatgg taggagccac 687061 atcaacgtct ccggcatatt tatgaacttt ctcgcccttc acgccggcag cgtggataaa 687121 gagcggcacc cgttgaagct gggcgttgtc gtaatcagtg atttcatcct tgccaagcac 687181 tttcgccatc gctttattgt ggttttcaga gatgccgtag tggtctccgt acatcacaat 687241 aatcgattta tcatataacc cgtctttttt cagatcattg aagaattgtt caatggactg 687301 atcaaggtaa tgggctgact ggaaatagtt atcgacgaca gagtcaccaa agtctccagc 687361 cgggaagtct gtatccccct catccattcc gaatgggaag tggttggaaa gggtaatgaa 687421 cttcgtatag aacggctgcg gcaggctttc cagcagcggc attgattctt tgaagaacgg 687481 tttgtctttc atgccgtagt ttttcgtgtt ttcttcgttc atgtcatagt aagcagaatc 687541 aaagaattta tcaatgcctt ccgccttgta catttcgtta cggttccaga acgtctgcgt 687601 gttcccgtgg aaagtagcag atgtgtaatt cttagacttc agaatcgccg gaacggattg 687661 cagcgtgttt tgcgctttgt ttacgaaaac tgaaccttga gccagcgggt acagagagtt 687721 ttccatcata aattcagcat cagatgtttt accttgtccc gtttggtgga aaaagttatc 687781 aaagtagaac gtttcgttat catgtgccag tttatttaag aatggtgtca cttctttgcc 687841 gtcaatttta tagtcgatga taaatgactg caaagattca agtgaaacgt aaatgacgtt 687901 ttttccttcc gctttgccga aatacacgtt attcggcaca tcgtaattgg ctttcatgta 687961 gttttctact tccgttacgt cgctggaatc ggcaagcgcg cgctggctgt tggacttgat 688021 attctgtaca gcgtcataaa tcgtgaaatt gtatgttccc aagtatttca caagatagtt 688081 ccggtcgaat gatcttgtca gcaattcagg acggtctgat tccgcaactg ccaggttgat 688141 caagaacaca agaattgaag acgcaaaaat aattcggaac gattttttgc ttgacgtttc 688201 ggcaggcttg tttactttga tcgccaagat gatcaggatg atcgtatcga taaagtaaaa 688261 ggcgtcagtc ggtctcatca gcgaaaatgc gctgtcaccg agttggccgc cgtttgtttt 688321 agcctgcata atgaccggaa ttgtaataaa atcattgaaa aatctgtagt acacaatgtt 688381 ggcgtacagt aaaaaagaca ttaaaaaatg aatcactata atggctgtct gctgtaattt 688441 tttcttgaac aagagtccaa agccaagaaa gaacaagctt gagctaagag gattcacaaa 688501 aagcaatatt ttttgtatcg tgttgtctat tcctaagttg aaattcagga cataaccgac 688561 atacgttttg atccataaca ggacgaccgc aattaagaag aaggccagtc ctctttcttt 688621 tataaatgtt ttcattgtta cactcctttt ttccgatcca gttcgagcga aacgatagaa 688681 aaaacgaacg tatccaatat aacacgaatc agcagattag aaaagtgaaa atcgtatgag 688741 ggagaaagtg gcgaaaaacg ccgtcgaatc aacgtttcgc tttgatatta ccaaatgtaa 688801 aacaaggtat ctttctagaa ataaaggaat aaaatggtac attgagaatt gtatgataaa 688861 atataaggta tagataaaaa gaggtgaaat gatggatttt tcccatattg tgtctgaaga 688921 taaaattaag cgcgccatca aagacgggga ctttcaaaac ctcccgggaa tggggaagcc 688981 gctgccgaag gatgacgcgg cacacttgcc ggaatcgctg cgcatgggct atcgtatttt 689041 gaaaaacgcg ggaatggcag aggacgaggg cgcgctcaaa aaagagctta tgaccatcga 689101 ccatttaatc gaaaagtgct atgacgaaaa agaacgcgag caattaatca gaaaaaaatc 689161 tgaaaagcaa ttgctgcttg ataagcttgt cgacaaaaaa ggcatgtttt caaagccagc 689221 atccgctttt tataagaata aagtatatga ccggcttgga cgaaacagac cttcttccag 689281 ctgatttgtc ttgtctgcag gatggcgatt gataaaagcc atccttttta tgttccaagt 689341 tctatgtcaa aaggtttatg tttttccatc tatgggaaat gattcataaa cgaaaaaagg 689401 gtgatgggat ggaacgacta ttagtatgga tagagcatat atctgattgg ctgtggggtc 689461 cgccgctaat catcctgctg acggggacgg gcttgtattt cactattttg ctgaaaggtt 689521 ttcaatttcg ctatccttta tacattttca aacagacaat cggcagtgta ggaaaaaagc 689581 cgaagggaga aggcacagtc acaccgcttc aggcattgac ctcagccctc agttcaacga 689641 tcggtgcagc gaacattgtc ggtgtgcccg ccgctattat gtttggggga ccaggagcgg 689701 ttttttggat gtggcttatt gccttatttg ccatggcgat taagttttct gaaagtgttc 689761 ttgctgttca ttacagagaa aaaaatgagc agggtgaata cgtcggggga ccgatgtatt 689821 acataacaaa agggctgcgc atgaaatggc tcggcgtatt cttctctgtt gcgctgattg 689881 tggagctgat tcccagcatt atggttcagg gaaattcggt ttcagtctcg cttgccgaga 689941 cgttttcttt caataaaata tacgcaggaa tcggaattgc atttttgatt gggttagtgg 690001 tgataggagg ggtaaagcgg atcggaaaag taacagagtt tgtcgtgcct cttatggcag 690061 gggcatacgc aggtgccggt ctcctgattg ttctcatgaa tctatcatca gtgccggcgt 690121 ttttctctct cgttttttca aatgcgttta cctcttcttc agcagttgga gggttcgcag 690181 gtgctgcgtt ggcggaaacc gttcgctggg gatttgcccg cgggctgtat tctaatgaag 690241 ccgggatggg aacagccccg attgcacatg cggcagcaat gactgatcat cctgtgcggc 690301 aagggttttg gtctgtgatc ggcattgtca ttgacacctt aatcatctgt acgactaccg 690361 cttttatcgt ccttgcatcc ggtgtatgga cagggaagaa cgcctcaaat gacccggcag 690421 cactgacaac ggccgcattt cagcactatt tcggttctgg aggaggatac ttcgtttcgg 690481 tttccctggt cttctttgtc gtatcaacca ttatggttgt cattttttac ggcgtaaagc 690541 aagctgaatt tctgttcggg cggctggcag gacatgtgat taaattcgtt tatttagcgg 690601 ctattatcat aggtgccgca ggcggagcaa aagccatttg gggcgtattg gacttagcat 690661 tggtttttat tgttgtcccg aatgtgattg cgctcttgtt attgagcaga aaggtaaaag 690721 cgctgtacac cgaattcttt acatctgaac agtactacct gaaagatata agaaaaacga 690781 aacaaaagcc tgtttatcca acaaaagaag ctaaaaattc ctagtgtttt gcttttgcgc 690841 cgaacaatgc tttgcttttt atgatcaaat aaatgagtaa aggcagcaaa agagaaatca 690901 ctacattaat gattggtttg attctgttaa agtcgattag ctgatttgta tttaaaaaaa 690961 accaaaagcc gcatacgact gagaacatgc cggttggtgt atacatggct ttcgggtcga 691021 tttttgagtg taaaaacgaa aggccgtata ccacgatata tagggaacct gctatcttca 691081 ccataatgac cggaatccaa aaagccgcga tgatcaggtc tgagcgatcc agaaaatccg 691141 taatgcggat ctgcctgatg accatataag caggatcaaa gaaagtagat gtcaggttgg 691201 gaccaaagac agaaattgaa gaaaataaca tcacggccag caataaagcg cccagcagta 691261 tcgcgaaaat ggtgtatttt agcgggacgc tccggtttga gaagagaagc ggaaggataa 691321 tcaattcccc cattgtccca aacgcgtaat agcctgattg aaggtatggg attagacctt 691381 caaaaacagg tgtcaagttt tgaagctcaa tttgtgtggc cagcgtaaat ggaaggaaca 691441 agaccaggat gccgaatgga aataggaata tctgcgccat tctggtcaat gtttcttttc 691501 cctctctggc aatacagatc gccacaaaga taataacacc gccaagaaca gccattggtg 691561 ttctcgggag aaataaaatg ttaatcaaat tgatgaaaaa acgtatatca tgagcattga 691621 ttaacaggaa atacaaagaa aacagtaaaa tgataatccg gcctgcgatt ggtgaggaat 691681 cgctcagcag ctcatagata tttttatcct gatgcttttt catcagccta tgcatgagcc 691741 agagtgccgg aatcacgatg acaacgccga ggatgtagct gtgccaggca ttttgttttg 691801 ctgattcgat catgagaatc ggagcatgct ttaatccgac tgctaacgta tacagagctc 691861 cgaaaaataa tccttggtat gcagaggtct tgtccataaa gcacatcctt tctgtcatgt 691921 tcaaaacgga atatatttaa acaggtgccc cagccgcgga agcaggggat tcactctcat 691981 ataaatccat agaaaagcac ttcctgcaat tagcaggctg aaggcccatt ttgttagatt 692041 gttagcggaa cgaaaattct tccattcata tgcgtatatg gcaatgcaca caatcaatgt 692101 ctgtacgata tagctgatca tgctgacgca cctccattaa tggctgatcg ttttgtatag 692161 gacaccgccc tgctcaatcg tcacaattgg gacgacgtga acctccatat ccttatatac 692221 ctcttcccat tcctttttca gcagattctt cgtggttgcc gtgcttctga tggtcctgtc 692281 ttgaaagccg gccgggtccg cctttagctt ttgcaaacga tgaacggtgc tgatcacgtc 692341 cttctttatg gttctgttta atgctttttg aatgatgtaa tactggtcat tttctctcgt 692401 ctcataggtt gattggtttt ccataataat tcctttggct ctgatctcga ttgtcattga 692461 cagctttccg tttttttcag cggcatgaaa ggatgcattg gacttttgaa gctgaatgga 692521 tgcttgcccc atttgattcg gcaggtctac tatgaattct ggctggcggg cttgattcag 692581 caacatcagg gctgctgtca tgtgttcatc tttgaaaata tccatcaatc tgtccttttt 692641 aaagatcgca agcccgtcaa ttttcaaatt agatttgcct ttccctccag gttttgtttt 692701 agatgcagag atgaccggtg catacggatc actgcctatt tctactagat cagacatgaa 692761 tctgcttaag aaaacggggc ggctcgttgc gataatggcc agctcccgaa tcatttccgc 692821 cggaaactgt tcaagctgaa catcggtatt taaaatgtcc cgcgcttctc cccggctgac 692881 taaaatgagc gccgttaatc tgttctgcgg atttcgcgtt aaaatatcaa agactggggc 692941 aacgccgtct ctcgccatat cctctccaat aatgactgta cgtctgtggg acgtattgat 693001 tgtccgtgac aaggaggttt gcagcttgtt gttcgcttct ctgatcgtag tgccggaagc 693061 tgaatcaaca taccatgttt ttgaaccggc agttccgccg ccgccccctg tttgtccgcc 693121 taattggccg accaagggaa tctgcatggc cactcgatac tgatcttttt tcttatcaat 693181 ggctgagctg acaacaaatg caatgtcatt gatttctgtc cggtcccagc accccgttag 693241 aaggatacaa atgagaagcg gcaaaacaca cttatatatt gttttcttca tcttttgggt 693301 cctctctttt cgctcccttc tgtccgttgc cgcgcgaata cgtgcccggc cttctggtca 693361 tcgtccacca aggcgccctg acaaaaatat cttttacttc atctcgttta aacggagaaa 693421 tcccggataa ataaggaatg ccgaaagatt gcagcttgca taaatgaagc actaagataa 693481 tcgtgccgag cataatgccg aatatcccaa aaatactcgc caaaaacata agcgggaaac 693541 gaagcatcct gatggagata gctaagttaa accgcggaat tgtaaatgac gcgatccctg 693601 ttaacgatac gatgatcacc atgggggcag acacaattcc cgcttcaaca gcggctgtcc 693661 caatgactag ggccccgaga atactgacgg tctggccgat ggttttcggc aggcgcactc 693721 ccgcctcacg gagagcctca aaagaaattt ccataatcaa tgcttctatg atggcgggga 693781 aaggaatcgg ttcacgcgca gaggccacac tgaacattaa gtttgtcggc attaagtcct 693841 ggtggtatgt aataacggca acataaatag ccggcaaata taaagcaacg aataaaaaca 693901 tatagcgaag ccagcggatt aagttagaca tcaaataacg ctcatagtaa tcttcactgg 693961 cctgcataag ctgccaaaac gtaatcgggc ctgttaagac aaagggcgta ttatctgtga 694021 aaatggcaaa tcggccttcg agaagctggg cggcgacggt gtccggcctt tctgtgtatt 694081 gcagctgggg gaatggcgag tacgtgtcgt cttcgataaa ttcttcaata tatccgcttt 694141 ctaagacagc atcaatcttt atctttttga ttcttttttt tgctttgtca ataacctttg 694201 gatcggcaag cccgtcaata taggccaaga caacatcggt tttggttttc gtgccgattt 694261 taaaagagat cattttaagc tgaaacgttt tgacgcgaaa gcgcacaaga gcggtattga 694321 ccctgaggct ttcagtgaag ccctctcttg accctctgat ggtcgattct gttatcggct 694381 cttcaatgct tcttctttgt ccgcctttta tatttaagat caggcctttt gagtgcccgt 694441 cggcaaataa aaccgcgttc ccctcaatga tggatgcagc cactttgctc atactcgttt 694501 ctaatgcaac acttgaaatt gatagagtat tttgcagcgc ctcttcatgt tcatctattt 694561 gatccgtcaa atgcattaag aaagggcgga gggcgtgatc ctgaatatgt tcagatttta 694621 caattccttc gatataaaca ataaatccgc acagcccgtt tccaaagtca aattgtctaa 694681 atacgatgtc tgagcagcct tctgttaata aggtcagatt ttcgaggttt tccttcaaat 694741 tgggagagat cggtctgtcc tgattgtctt caagctcttt gatgagctga agcgctttgt 694801 cgcgtttatt catagaggct caccctgctt tttaatgtca tattcaataa gtgcttgtga 694861 cttttagggt aaccttgtct gtttcatata ttccagacta ggatgaaagc gctataaaaa 694921 agtgttgact acctgtatat acaggaatac aatatgatta taagttgtat atacaagtta 694981 taaaaacgga tacggagggg ttggcatggg ggaactgaac aaatcggcac gtcagattgt 695041 cgaagcagtc ggcggtgctg aaaatattgc agcggcaact cattgtgtta cacgtttgcg 695101 ttttgcttta atagatgaaa gcaaggttga ccaagagatg cttgatcaaa ttgatgtggt 695161 aaagggatca ttctcgacaa acggacagtt tcaggtcgta atcggccagg gaactgtcaa 695221 taaagtatat gctgaactgg ttaaggaaac ggggattggc gagtcaacaa aggatgaagt 695281 gaagaaggcc tcagaaaaaa atatgaatcc tttgcagcgt gctgtgaaaa cgcttgcaga 695341 tatttttatt ccaatattgc ctgcgattgt cacggcgggt cttttaatgg ggatcaataa 695401 cattttaacg gcggaaggca ttttcttcag cacaaaatcg attgtgcagg tttatccgca 695461 gtgggcggat cttgctaata tgattaacct gattgcaggc acggccttta cgtttttgcc 695521 tgcgttaatc ggatggtctg ccgtcaagcg gttcggcggc aatccgcttc tcggcattgt 695581 gctcggggtt atgctcgtgc atcctgattt gctgaatgcg tggggatatg gcgcggcaga 695641 acaaagcgga gagatcccgg tatggaatct attcggccta gaggtgcaga aagtcggcta 695701 tcagggccag gtgctcccaa ttttgcttgc ttcttatatg ctggcgaaga ttgaggtatt 695761 tttaacaaaa cgcacacctg agggcataca gctgctcgtt gtcgcaccaa ttacgcttct 695821 cttaacagga tttgcctctt ttatcattat cggcccgatt acatttgcga tcggtaatgt 695881 actgacttca gggcttatct cggtgtttgg ttcttttgcc gcactgggcg gtctgttata 695941 tggcggtttc tactcagcgc tcgtgattac cggtatgcat cacacgtttc ttgcagtcga 696001 cctgcagctc atcggttcaa agctcggcgg caccttttta tggccgatgc tggcgctttc 696061 taatatcgca caaggttcgg cggctctggc catgatgttt atcgtgaagg atgagaaaca 696121 aaaaggcctc tccctcacat cagggatttc tgcttatctt ggcattacag agcctgccat 696181 ctttggggtg aatctgcgat acagattccc gtttatcatt gcaatggtca gctctggcct 696241 ggccggaatg tatatttctt ctcaaggtgt gctggcaagc tccgtcggtg tcggcggcgt 696301 gccggggatt ttctcaatca tgagccagta ctggggcgcg tttgcaatcg ggatggctat 696361 tgtattgatc gtgccgtttg ccggaacata cgcgtatgcg agattcaaac ataaataaca 696421 agtggggagc gggacgtgtt gaacgttccc ttttcccgtt ttcaatttaa atatggtggt 696481 ggaaacagat gaaaacagaa caaacgccat ggtggaaaaa agctgtggtt tatcaaattt 696541 atccgaaaag ctttaacgat acgacaggaa atggtgttgg cgatctgaac ggcattattg 696601 aaaagctgga ttacttaaaa acgctacagg tggatgtgct ttggctgacg ccgatttatg 696661 attctcccca gcatgataat gggtacgata ttcgtgatta ttactcgatt tatcctgaat 696721 acggaacgat ggaggatttt gagcggctag tgtccgaagc acataaaaga gacctgaaag 696781 tcgtcatgga tcttgttgtc aatcatacgt caacagagca caaatggttt cgcgaggcga 696841 tctcttcaat agacagcccg taccgtgatt tttatatatg gaaaaaaccg caggaaaacg 696901 gttctgttcc gacgaactgg gaatcgaaat tcggcggctc ggcatgggag cttgacgaag 696961 catcgggcca atactatttg catctgtttg atgtgacgca ggctgatttg aattgggaaa 697021 atgaagaggt cagaaagcat gtctatgaca tgatgcattt ttggtttgaa aagggaatag 697081 acggctttag gcttgatgtc atcaacctga tttctaaaga tcagcgcttt ccgaatgcgg 697141 aggaaggcga cggccgctct ttttacactg acgggccgcg ggtgcacgaa tttctgcatg 697201 aaatgaacga aaaggtgttt tcacattacg acagcatgac ggtcggtgag atgtcttcaa 697261 caaccgtaga ccactgcatc cggtatacga atcctgacaa taaagaactt gatatgacat 697321 tcagcttcca tcatctcaag gttgactatc ctaacggcga aaaatgggcc ttggcgccgt 697381 ttgatttttt gaagctgaag gagatcctat ctgactggca aacggggatg cacgcaggag 697441 ggggatggaa cgctctgttc tggtgcaatc atgatcagcc gcgcgtcgta tcaagatatg 697501 gagatgatgg cgcatatagg gtgaaatcgg cgaaaatgct tgctacggcc attcatatga 697561 tgcagggcac gccttatatt tatcagggcg aggagctggg gatgacgaat ccgaagttca 697621 ctgacataag ctcctatcgg gatgtcgaat cgctgaacat gtatcacgcc tttaaggaaa 697681 aaggaatggc tgatcaagat attacagcca ttttacaggc gaaatcccgt gacaattcca 697741 gaacccccgt tcagtgggat gctacggaaa atggtggttt tacaacgggc acaccatgga 697801 taccggttgc aggaaattac cgggaaatca atgctgaagc ggcgctgagg gatcagaatt 697861 cggtgtttta ccattatcaa aaattgattc agattcgcaa aatgtatgac attgtgacag 697921 agggtacgta tgagataatt gcaaaggatg acccgaacat ttttgcgtat ctcagacacg 697981 gcagcaatga aaagctgctc gtgatcaata atttttacgg gacagaggcg gcctttacac 698041 tgccggactc tttagcgcct gacgaatgga aggcagaggt gctgttgacg aacgatgaag 698101 caagggaagg gcttcagaac atgacgcttc gcccatatga gtccattgtt tatcgtttaa 698161 cgaaaccgtg ttaaactaag ctgggtggtc cataatgaag gtgaataaat tcatcacaat 698221 ttataaagac atcgcacagc aaattgaagg cggccgatgg aaagcggagg agattcttcc 698281 gtctgaacat gagttgaccg cacagtacgg tacatcaaga gaaacggtcc gaaaggcgct 698341 tcatatgctc gcgcaaaacg gttatatcca gaaaatcagg ggaaaaggct ccgtcgtgct 698401 caatcgtgaa aaaatgcagt ttcccgtttc gggccttgtc agcttcaagg agctcgcgca 698461 aacgcttggc aaagaaacga aaacaactgt acacaaattc gggctggagc ctccgtcaga 698521 gctgatccaa aaacagctcc gggccaatct ggatgacgac atctgggaag tcatcaggtc 698581 tagaaagatt gacggggaac atgtgatttt ggacaaggat tactttttca gaaagcatgt 698641 ccctcacctg acgaaagaaa tttgtgaaaa ctccatatat gaatatatag aaggagagct 698701 cggtctttcg atcagttacg cccaaaaaga aattgtagcc gagccgtgta cggacgagga 698761 cagagagctg ctcgatttac gcggctatga ccatatggtc gtggtgagaa actacgtctt 698821 tttggaggat accagtttgt ttcaatatac ggaaagcaga caccgtctcg acaaattccg 698881 atttgttgat tttgcgcggc gggggaaatg agagaggcgc ctgcctgcgg cagcgcgctt 698941 ttttgtttgg tatcaaaatt gatactatcc aacaaaaatg tgcgtacttt tactttttat 699001 cataatggct acaatagaga tgagagtaat ctaaaggaga ggtgttttac atggcagatc 699061 taaagacaca aattctggat gcatacaatt tcaggcatgc gactaaggaa tttgacccga 699121 ataaaaaagt gtcagacagc gattttgaat ttattttaga aacaggaaga ctgtctccga 699181 gctcactcgg ccttgagcct tggaaatttg tcgtcgtcca aaatccggaa ttccgcgaga 699241 agcttcgtga atacacatgg ggcgcgcaaa agcagctgcc gaccgcaagc catttcgtcc 699301 tgattcttgc gcgtacagcg aaggatatca aatataatgc ggactacatc aaacgtcatt 699361 taaaagaagt aaaacaaatg cctcaagacg tgtacgaagg ctatttaagc aaaacagaag 699421 aattccagaa aaacgatttg catttgcttg aaagtgacag aacattgttt gactgggcat 699481 caaaacaaac ctatatcgcg cttggcaaca tgatgactgc cgctgcgcaa atcggtgttg 699541 attcctgccc gatcgaaggc ttccagtacg atcacattca ccgtattctt gaagaagaag 699601 gccttctgga aaacggaagc ttcgatattt ctgtgatggt ggcattcggc taccgagtga 699661 gagaccctcg tccgaaaaca agatctgctg ttgaagatgt tgtgaagtgg gtttaaaaga 699721 agaaagctgc tcgcatagcg agcagctctt ttttatgcct gattcgctct attctgtttt 699781 ctcctctgat gtaagtacat tgccgttccg agtgcgctga tcagaaatcc ggccaacagg 699841 atcgagtaca tggatgtggc tgtgtccgga agcaggccgc cagccggacc gtctgttcct 699901 gatccgcccg aaccgtttcc accagagccg ttagtcggtt gagtgccggg aggcgtatca 699961 tttcctccgt ttccgtcagt tggctgtttt ccgcctggtt tgtcggagcc tccgccatga 700021 ttgccgtcat caccgcctgt cggttgatct gacgggaatg ccggcggttt gttgtttgaa 700081 ccggaattta agatcgtgta ttcgctgaag tggtttgtat atcctgtcac catatcatca 700141 tcgactgatc cgtgacctgt ctttgtgaaa gctttctttt ttctatcgac gtgataaatg 700201 gcagggttat gggcttcttc aatatcaaac atgcgaagcg aaagctgtac gggctccttg 700261 aatgatttta tttcttttcc tttttgcttc actgtaaagt catatacatc tgacagtgac 700321 acatccaatt ctcccgtaga cttgattccg attgcagtgt ctgcggtttt aaggttcgcc 700381 attggcatct tcatgctgta ccagtagttg aacatcgtca atgaaggatc tgactctctt 700441 tctttcaaaa gtttgacctg atcttttttc actttaagat tgataggctt ctcttgagat 700501 ccttcatgta ttccataata gacaaatggc gtgttggcat ttttagcata aatcgcaaat 700561 ttgtcttcat caagtgtcca gctgccgtcc ttctgctttg tcggcaggaa tacttctttg 700621 attcgtcctt caactttagg agagaccttg tttcctagtt ttttcagctg ttcggtgaaa 700681 atctcataat caacgtagcc aaggtcttca ccatgggagg cttctgtaaa gacagaatat 700741 ccgtctcctc cggcaccgac aaaattattt gttgccacgc ggtaggtatc atccgtattt 700801 atagcaactt tgtctccgtt aggcgattca attttcactt ctaacacacg gtgtccaggt 700861 ttgttgttta atgtaaaggt atattcgatt ccggccacct gagggaaagc gccgccgcca 700921 ttttccacat tgcttaggcc ttgttcaagg gcttctttaa tttgttttcc ggttaaatcg 700981 gccacgtaaa gcgtattgcc gaacggcatc acgttgagca cctcgccgag tgtgatatca 701041 cctttgtcaa tgcctgctct gatgccgccg ccatttgtta tcgctattct ggcgccggct 701101 gcttctttcg cttttgccag cataccgtcc gcgatgaagt ttccgagatt cgtttctttc 701161 gtgcgcacat gctcacgctg gccgtcaagc gccacatccg tgtagccgac tttttcattt 701221 ttcacgtcct ctaattcatt tttgaactga tcgagctctt gttttgcttc tgggttttct 701281 tctgtatgtt catcaattgg cagcacgctc agatttgatt tatctgtttg cacaacgcct 701341 ttttcatcaa acgcgacatc aacgcgcccc aagaattggc cgtattcttt tgcctgcgcc 701401 acgatcgtcg gttcttcgtt gttcacgacc tccattttgt ctacgagggt gtgagtgtgt 701461 ccgccgatga tcaaatcaat gccttttact tttttggcta gctcaagatc ccggttatgt 701521 ccgatgtggg ttaaagcaat aattttattt accttttctt cttcttgaat cgctttgacg 701581 gtgttttgtg ctgtttcaaa ggcatcattg aatacgatgc ttttgcccgg gcttgatgtg 701641 gtggctgtat cttctgttgt caggccgaat acggcgactt tctccccgtc aacgtctaac 701701 agaatgtaag ggtgaatgcc ggcctctttc ttttcacctg ccgtaaaggt ttgcggcttt 701761 ttgacaaatg atttcagctt gggctcattt gacacatcta cgtttgcact gacaatcgga 701821 aattccggcg cttcaaagtg atagcggttc gccggatcaa cggttgcgct gtttccgctt 701881 agaaaatcag aaagcaccgt cgggcctttg tcaaattcat ggtttccgaa ggtcatggcg 701941 tcatagccca tcatgttcat cattttcaga tcggccaaac cgttccattt agtaaaatac 702001 agatcgccgg aaaacacatc tcccgcatca aggagaatat tgtgatttgt ttcgctgcgt 702061 acttcgttga ttttcgtcat tcgtctcgct gcatcatcga gatgggcgtg cgtatcattg 702121 gtgtgcatga cggtcagatc ccacagtccg tctttaggag gatctggatt tgaatcatca 702181 tcgaattgca gcttatacac accatagcct tcattcgcag acttgcctac ataagcgaca 702241 tcgtctgctt tatcggcaaa tggcttggcc aaaagcgagg attcaaacgt cagattcgtg 702301 ccggaaacag gcgcgattga ccagttgttg tctgcttttg gattgactgt tttttgttca 702361 ataatgtaat ccatcagcac ctgcctattt tcaactgcag agccgtggac aattttatcg 702421 ctcgtcagat gagggaaccc gccgcctccg gacgcacgat agttattggt gactacgaga 702481 aattcctggc ttgggctgat cggcttgcct tcataggaaa gattgatgat acgggatgaa 702541 tccgcattga tcacttttcc gttctcattg tatttagccg gttttgtcac atcgacctga 702601 tatgtgacac cgtcaatcac gtcaaaatta taggagcgga aattctcgtt cagcaaggcc 702661 tggtcgccgc ctttagctgg atcaatttga ttgaattggc ctgctgacat ctccagccag 702721 tccttgacct cgctgcctgt cagcttgacg atttgaacag tattatcgta aagatacaag 702781 tcaccgacat ttttaatcgc aagatctccg gctggaatgt ttgtatagta attggctccg 702841 tttctgccgc ctgctttaaa cggcgctcca gcggataaaa tcggcaggtt cttgtactcg 702901 gtatccttca tttctttttc agcgtaccac ttttgcgcgt cagtcacgat ctgaatggaa 702961 ggatcatctt tgacctgtgc aaagaagctg ttaatatctg cttcggtttt gccgactggc 703021 tttcggacat actccagtgt gttttggtgt gtttgctgaa tggtgtttgt aacggtttcg 703081 tttcttgatg tgacgttgcc agcaatagat tcaatacttc ctttggaatc tgctaccttc 703141 catgagccgt ccgccttttc aagcttgagg tcaatcacgc ctaaatattt gccccagctg 703201 cttggcatga cgacaggaat gccgttaatt gttccctttt ccacattgaa ctgagcaaca 703261 cccgcatact cggcggaagg aaagagtccg tgctgatggc ccgagataat cgcgtcaatg 703321 cctttcgttt tggtggcaag gtcaaacacg gcgttttctg cgcctgatga ttgcgcctgc 703381 ttttcaatgc cggtgtgggc gagggcaata atgacatctg cgccttccgc cttcattttc 703441 gggatcgttt cattggcgga ttctacgata tcctgcacct gaacttgccc ctcgagattc 703501 tttttgtccc atgtcatgat ttgcggcggg acaaagccta tgtagccgac ttttactttc 703561 tgctcattac cgttttcatc aatgagggtt ttttcattaa tcacatacgg cgtataacgg 703621 ttttcgccgc tagttgtttt gacgttggca tttacaatcg ggaaatcggc tcctttgatt 703681 gtgccgtcga gaaagtcgag cccgtagttg aattcatgat tgccaagcgt tccggcgtcg 703741 tatttcagcg cattcatgac gctgataatc ggatgggttt tcgtgccgga gataatgtcg 703801 tctttttgat atttcaccgc gtattcaccc agcggattcc cttgaatcaa gtcgccgtta 703861 tccacaagca gggtgttagg gttttgctcg cggtgctttt ggatcaattg cgctgttctc 703921 gccagaccga aatccgccgt ttctttgtcg ctgtagtaat cgtaatccat catgttggca 703981 tgaatatcag tcgtagccaa aatactcaga tgcacctgag gagccgcgct ttcttctgca 704041 tgaatgggtg gtgttgggag gattaggcta agtatcataa ttgggggcaa aagaatacgg 704101 agaatgtttt cgacgtgtgt tcgtcttttc tgtattctca ccagttctcc acctttcaac 704161 gaaatttgtg ttacagctcc tattgtaaga atattttgta actatttgta ggtgtttctt 704221 tatgattatt gtaaaaggga gaaaaatgag tattatgtag cagtatcaaa cgacaaatac 704281 tgggcattta tgcttatcgt ttgtcacaat cgcggaatgt ttattttagt gtggctgggg 704341 tagagtgttt tatgtagaca tataaagcgg gaggttatga atcatgggga aaaaaattgc 704401 agttgtttta acatattatt ttgaggacag cgagtacact gagcctgcga aagcctttaa 704461 agaagcggga catgaactga ctgtcatcga aaaagaaaaa ggaaaaacag taaaaggcaa 704521 gcagggaaca gcggaagtga cggttgacgc gtccattgac gacgtaaatt cttcagactt 704581 tgatgcgctt ttgattcctg gaggattttc accagaccag cttcgcgctg acgatcgttt 704641 cgtccaattt acaaaagcgt ttatgactga caaaaagccg gtatttgcca tttgccacgg 704701 cccgcagctt ttaatcaatg cgaaagcgct cgacggccga aaagcgacgg gctatacgtc 704761 cattcgtgtt gacatggaaa acgccggtgc cgacgttgtg gacaaggaag tggttgtttg 704821 ccaggatcaa ttggtcacta gccgcacacc ggacgatata ccggcattta accgcgagtc 704881 attggcattg cttgagaaat aagaaaaaac ggacgctctt gggcgtccgt ttttttgttg 704941 cttaggcttg agcacctgtc agtttcttgt acctgtaata caagaaagca gctgcagccg 705001 ttccgatgac cgcaatgccg aagtcgaata tgaaaatatg ggcgatgccc cccgcttttg 705061 cgataagccc tgttgcaatc ggcagcagaa tcgatgcaag acttgaagca gtcgctacaa 705121 ttccggtaac ggttcctttt cgcttccaga aaagctctgt cattaacgta atggtaattt 705181 gaaacacacc cgcagttgaa aagcctaaga aaaaggcagt gatgtccagc acaactggga 705241 tatgaacggt cagcatgact gcgagcgtac ataaagtaat aataggatat aagagcgtta 705301 tgaagacagg tttgacccat ctattcagca aaacggctaa taataaaaca gatgccagag 705361 atcctatact ataatagctc agcaattgta cagatgctga ttcagctaaa ccggctgcct 705421 tttgcgcgta gctcgggagc cagatttgag aaaccgtaaa taaagccgtg gatgtaaaac 705481 cgatgataat cagtgcggtg ccttccttct gaaaaacggg ttcagacaag aaaacgggag 705541 attcctgttg gccgctatta gttggtttct tatgtttttt aggaaacgaa agcgttgata 705601 aataaataat attcaggaga tagaccgctg ccggcagata aaaagcaaat ccgtaaaaca 705661 tgctgtggtc tgctaaaaat gtgatcaaaa gcggcaaaag tgcggccccc acagacataa 705721 aggctttaac caagacattt gccgaaccgg aagcagacgg aaagagctcg gttagggccg 705781 gatatgttcc ggcatccatg gctgaattag cgactccggc taataaagcg aacacaaacg 705841 ccagctcata gctcggtgat aaaggaatac cgactaaaaa gacggccata attcccgcag 705901 aagcgacaac aagcggcttt ctgccgattt tatctgatag aacgccggaa atgccgtatg 705961 tcagcagttt gccaaacccg atagcggcaa tgacataact gatgccggtc ggatcggtat 706021 tccactgttt tgttaatgaa gacatattgg atgcgagaat gatgttgacc atccccagaa 706081 agaagtagtt gatatacatt ccggatgctg ttttgataga tgtcgtttgc atgcttgtac 706141 tccttcaaat cttattcgaa cactttgctg ttttggtttg gggaaatgat aaaaaagact 706201 cgccgagttt ccggccagtc tccattattt acgaagcgag gctaattctt gagcaatcgc 706261 ctgcatttca cttgggctga atgattcttt tttcatcacc attctgtgaa ggtacgtgag 706321 gtcttcaatc ttctcatcac tgaaatcctc cgctttgatt acgccgacgt tcagcatgtt 706381 cagcttttgg gaaatctctt caatcatttg agttaatgtt tctgtatttg ggctggacaa 706441 agggttccat cctttctatg cgcaatatag gtatgtttta ttctaacaga attccatcag 706501 aaaaaaaccc tattctaaaa gcaggctgtt cattccaaaa aagtgaagac atcagttgaa 706561 aagaaaatga acatcctact aagatattca tgaaggtttc tttttagaga aataggggca 706621 aagaataggg aggttgcaca tcatgataag cgtgttattt gtttgtttag gtaacatttg 706681 ccggtctccg atggcggaag cgatttttag ggacctggca gccaaaaaag gattagaggg 706741 gaaaatcaag gcggactcag ccggtattgg cggctggcac atcggcaacc ccccgcatga 706801 gggaacgcag gagatattgc gcagagaagg aatcagcttt gatggcatgc tggcgcgtca 706861 agtcagcgaa caggatctgg acgattttga ttacatcatt gcaatggatg cagaaaatat 706921 cggaagtctc agaagcatgg cgggttttaa aaacacctcg catatcaaaa ggctcttgga 706981 ctatgttgaa gattcagatc tggctgacgt acccgatcct tactacacag ggaactttga 707041 agaggtctgc caattaatca aaacgggctg tgagcagttg cttgcatcca ttcaaaaaga 707101 aaaacaattg tgagtgaaag gagaatttgc atgaacaacg aacgtttaat gctgaaaggg 707161 atatttctcg gagctgcggc aggcgcggcg ttatcactgc tccataagcc gacaagacag 707221 gcgtgcggga tgagatggct gacatgcaag cataaacttt cactgtacaa aagcaaccca 707281 gagctgttaa aaaacactgt catcacaaaa gtggatgagg ccaaaaagct cgcccgaacg 707341 ctttcaaagg aagtcgactt tgtgaaccag caggtgaaag agctgaagaa aacaacgccg 707401 caagtgatgg aactcgtgca agaaacgaaa gagcattttt caaaaaaatg atcaaacatg 707461 cgaggtgaga cgacatgagt tttttgaaag agcttttcag cagatacacc cttcatgaag 707521 gacaaagtaa atcagcggag ctggcgtatt tttttctatt gtcactgttt ccgtttttga 707581 tttttatgct gacgctcacc gcgtatcttc cgctttctac cgatgatgtt ttaggagtca 707641 tagaacaata tgctcccgcc agtgcgatgt cactcgttga atccattacc catcaaacct 707701 taaataatcg aaatggcggt ttgctgtcat tcgggattat cgccgcatta tggtctgcgt 707761 ctaatggaat gaatgcgatc gtccggtcgc tgaaccacgc gtatgatgtg gaagaaaacc 707821 gctcttttat cattgttcgt ctaacctcga tttttttgac gattgccatg gtatttacga 707881 ttttagtggc tttgcttctg ccggtatttg gccgggagat tggaaggctc gcttctgact 707941 ttgtcggcgc gtcggatctg tttttatccg tctgggccgc cattcgctgg ggtgtcagcc 708001 cgcttgtgct tttgattgtt ttttccgcgc tgtatgtgat tgcgccgaac aaaaagctgt 708061 ctctccggtt tgtcatgccg ggtgcggtct ttgcgactat cggctggatc attgtcagca 708121 cattgttttc attttacgtc agcacgtttg cgaactatag cgccacttac gggagcatcg 708181 ggggaatcat cgttctgatg atttggtttt acttgagcgg cattttaatt atcctaggcg 708241 gagaaatcaa cgctctttta cataaacgta aaaagcttcc tgatgaaaat ccctaccatt 708301 agcgcaccct ataaacgaac ttcggttcaa aaagaagtcg gggggatatc gtgatgacca 708361 agcatacgaa aaaaggcgga agccataaca aacaaaactc gaaaagcaaa tcgagccata 708421 aaacaagcgg aagcgccaac ggacaaaacg gctaccatta gcataaaagc ctcctgacat 708481 gatgtcggga ggctttttga ttaagaagat gaagaatagg tttcagccgg tgaccagctt 708541 ttcggtttgc ccagcacaag ggccagccac acagagctaa gcgtgagagt aatgaagtag 708601 aacaagtttg cgctttcaaa tgtctgcata taccagccgc cggcaactgg gccgaggatg 708661 ctaccgagac tgaatgtaat gccgcaaagc aggtttcccg ccggcaggag gtgaggcgga 708721 agaaggtctg tcatatagct gatgccaagt gtaaaggttg atccgactgc cattcctgca 708781 ataaaaaagc agccgccgat cacgtagggc gaaggaaata caccggcgat gaaaaagcaa 708841 agagccccag tcagtaaaat caccagcagc acattccgcc tgccgtattt atcgctgagg 708901 atgccgagcg gaaactgaaa gataatgctt ccaatcgcaa atgcgggaag gatgatcgct 708961 actgcgtcta ctgatatccc caaacggagc gcgtacaccg gaaagcttcc gttcagcgcc 709021 gtttccagaa agccatagcc aaatgtaggc ataaaggcaa cccacccaaa cagcatggcc 709081 tgataaaatc gcctgaaact attgtctgat ttggtttcat gaggactggt ttccgggtat 709141 gcattttgta gaaagaaaac aaaaagccac gcaaacagac tgatgcagcc ggacacgata 709201 aaaggaagcg acggactcag cttgacaagc ggcaccatga acgggcctgc ggcaaagcca 709261 aggccaaagg aaagcccata aatagacagg tttcttccgc gattttgttt tgatgacatg 709321 gaggtcaccc acgtttgcgt agaaaagtga agcatgtggt cgccgattcc aatgaacagg 709381 cgaagcagga accagaccca aactgactga agccaaataa atccgaataa gcttaaaatg 709441 acaatgcttc cgcccatgac gatcagcggc ttgaacccga gctttctgag cggtgcttcc 709501 ataaacggcg aagccaaaag cacaccgata tacagcccgg tcgcgtgcag gccgttgata 709561 gcagcggatt ctccatttgt ttcaaaaatg attgaaatga caggcagcag catgccttgt 709621 gaaaacccgg aaatggaaac gagcaagaca aggataaaga aatgaaatcg tgacatcgtg 709681 tcagttctcc ttatatggaa tctatgttga tcgtacaacg ttttccaaaa gcaggcaacc 709741 tgaaaaaagc ctatatcacg ctatacattt gccctcgtgt aatcatgaag gtttttgtga 709801 agaataaaaa taaaacaagt cataaaaaag gagctatttc accatgaatc gtatcttttt 709861 tattttagtg gcggccggtg ttccgctttc tgtgattggc agtttgatgc attggccttc 709921 cgcggttcta tttgcagttt attgcgtgac gattatcgcg cttgcaagct atatggggag 709981 ggcgacagaa tcactgtcca tcattgcagg accgcgtatc ggcggtttgt tgaatgcaac 710041 cttcgggaat gcggtggagc tgattatttc cctttttgca ttaaaagaag gcctgacagg 710101 aatcgtgctt gcctctttaa ccggttcagt gctggggaac ctgttgctgg tagcgggcct 710161 atcgtttttt gtcggcggtt taaaatataa gcggcaggaa tttaatatcc atgatgcccg 710221 ccataactcc gggcttctga tttttgccat cattgtcgcc tttgtgattc cggaggtatt 710281 ctctgttggt atgggaaacg ccagcaagct caatttaagc atcggcatca gcatcattat 710341 gattctgtta tatgtggcgg cgctgtactt taaacttgtc acgcatcggg gcgtttatca 710401 gccgaataat gccgctcaga ctgaagaaga ggaagagcca gaatggtcag ggaaggttgc 710461 gacgattgtc ttgtttgcgg caacgattgt ggttgcatac atatccgaaa acctggtcca 710521 tacctttcac tcggtggctg aacagttcgg gtggagcgag ctgtttattg gggtcatcat 710581 cgtggcgatt gtaggaaatg cggcggagca tgcgtcagcg attattatgg ccttcaaaaa 710641 taaaatggac attgctgttg aaattgcagt aggctctacg ctgcagatcg ctatgtttgt 710701 cgcaccggtt ctcgtcatct gttctatctt ttttccgaca agcatgccgc ttgtatttac 710761 attgcctgag ctcgtcgcga tggtatcagc ggttctcttg atgatcgcga tttcgaatga 710821 cggggattcc aactggtttg aaggggcgac actgcttgct gcatatgtca ttatggcgat 710881 cggctttttc cttctttaac ctgaaaaaat gatggataac aacaaagcgg gatgaaaaga 710941 ctaagggaaa atgccataga aagagtgata tgatgaaaaa gctatttcat tccacactta 711001 ttgtgttgtt attctttagt tttttcggcg ttcagcccat ccacgcgaaa aagcagttta 711061 aggttcctaa ttctgtcgca agcatttcaa aggaaaacac gtatccgaat gcttcacagg 711121 atcagccaat gcttcagccg agcaagctgg caaaggaatt gctcgatcat tctgaggtaa 711181 agattgaaaa tccgcatctc atcaaaatgc tgaatgaatc caacatatcc ggcacaccgc 711241 ttgcagtagg gtaccgggcg acaatatttc tcgggaaatg ggcgctcggc tatgaatcaa 711301 atgaaacagt cgcaaactgg gaatataaaa aaatcaatac aaaccgtgcg gataaccgcg 711361 gcgggaaaga aacggctgaa atgcattatg cccaggaaca gcagtacaga gtgaagggcg 711421 gcttgacagc taaagttcca aatgctgaag atgtcaaaag catgatgatg caaaaagcaa 711481 tgaagaaaac gaacctcccg cttgcatttg agacggtcat cggggctggc acaaaacggg 711541 atcagattta taaagtcgct cctaaaaaaa tcggttatct acatgcatat gcaccggctg 711601 tgaatgaaaa aggaaaagtg acttacggag aagtgtactt agtgctgaaa ggaaataaac 711661 gaaaactcgt cgtgaaaaat gtcacgtcac agggaatcgg cgcgtggatt ccggttcaag 711721 atcatgtcac gtttggcttt cagctttcct cactgccaag ataaataaaa aactgattcc 711781 aactcggaat cagttttttt gtttattggg ttctctcgat tcggaccgct tcctcaagca 711841 tttgcacatt gttttggtag agctggcgaa cgagaacccg tcttactgca aggctggcac 711901 tgaaataatc atcatctttc accatgcctt taaccgtaaa ttcgacgccg cgattgattt 711961 tattcaatgc ggtgatgccg tggatttgaa acggttctgt cggattgccg aattcatccc 712021 gcttcaatga atcacgaagc tcttcattca gcatgtcaca tgcctcttcc aacacgctgt 712081 acacgcggtc cggatcttct ttaaagctga taagaaagga ttcggtaatc cgcataaaat 712141 caatattata gttctctatt tgtctgacct cgccgttgct gatggtgagc agcttcccgc 712201 tccattcccg gatttgcagc gagcggaggc cgatttcctc cactgtcccg ttgaacaagt 712261 tgttgacggt gacataatcg cctttgtgca gctggcgttc atatattaag aatacaccag 712321 ccagcacatc tttgatcagc gattgggcgc caaaaccgat cacgatacct gctacgcccg 712381 ccccggccaa tatcttgccg aaatcatgca caaataaaga aataacgtaa aagataaaac 712441 caattgttgc cgtatactgg gtgacagaac ggacaaggct ttcaatcgtt ttttcctttt 712501 tttcttcaat aaagtccgtc cgtttaaaaa atagctgtac cagccggttg atgataaaga 712561 caccgatcca aaggataacg gcaacgagga gaatatcgac gattttattt tgaaaaatct 712621 ccgtaagtgt ttctttcatc cgcatctaac tcctggcttg acgttttgtg aagtctgtat 712681 cctgataata actgtttttg acaagaacat tcggtccgag gcaccggaca ttcgggcagt 712741 ggcaactcag ttctttcgca agcttggtct ctctccactt ttcataggcg gaagggaggc 712801 tgtccgtctg aatgttgcca agcggcgggg tatcaccgaa atcggtcacg ataatgtttc 712861 cgtcgaaaat gttcacattc aggcgggatc ggccgtcagg gtcatttcgc actgtgacgt 712921 ttttcgccgc gcgaagccgg cgaagcagct tttggtcgtc ttcgtccgga ctgcaggcat 712981 aaaacggcag cgttccgaac agcatccacg tattttcatc acgaatatcc agcaagcggt 713041 gaatggcctg tctcatctct ttcaggctga gggattcaag agcgcttgcg aaatcgcttg 713101 gatacattgg gtggacctcg tgacgctgac atttcatatc ttctgtgatt tggcggtgaa 713161 tatgctcaat atgcggaagt gttcgtttgt tcagcatcgt ttccgcagat accattactc 713221 cggcatccac gagcgtgcgg ctgttttcga tcattttttc aaaatagcgc gcgcgctgtt 713281 cgaaggtcgg ttttctgtcc atcatggcaa agccgatttc agcaaaatct tcaactgttc 713341 cccagttatg tgaaatatgt agcacatcga gatacggaat gatccattcg taccgctcga 713401 tgtcgagggt cagatttgaa ttaatttgtg tccgcacacc ccgttcatgg gcatatttca 713461 ataaaggaac aacatattct tttactgatt tcaacgaaag catcggctct ccgcctgtga 713521 tgctgatgga tctgaggcgc gggatttcct ccagccgttt taacagaaga tctattggca 713581 gagcattcgg gtctttaggc tgcaatgtat agcctacagc acaatgctcg catctcatat 713641 tgcacagtgt cgttgttgtg aattcaacgt ttgtcagctg catgtctccg tattggtcaa 713701 catccatata ggcttcccaa gggtcaaact cgggcgtaat cggacgcagc ttcgtgtttt 713761 gtgtcatgac tatctaactc ctttataaat gggcatacta acgctgccaa cagttaattt 713821 tagacctgat ttgccaagat cgcaagtagc gcggcgattg aaaaacggca aaaaatgagc 713881 taccataata aaaaatgaat ggaggaacag aatggggaac gccgtaaaca ataaagatca 713941 gcagattgat tatttaaaga acagacttga catgtttatg aacgtcatcg attcattaga 714001 ccctgaagca accgacgttg aagatataga caggcttatc agcatgcttg atgacctgga 714061 agccaaatac gaacgtttta aaaaagattg ggaataaaac cgcgtgcccg ccgcggtttt 714121 tttattggca taaagcaaca gtataaaaca aagtctctat ctgtaaaata agaaaaaatg 714181 cagaaggagc gctggccatg aagtggatgt gttcaatatg ctgcgccgcc gtattgcttg 714241 ccggaggtgc agcacaggcg gaagcggtgc cgaatgagcc gattaattgg ggctttaaac 714301 gaagtgtcaa tcatcagccg ccagatgccg ggaagcagct gaacagttta attgaaaaat 714361 atgacgcgtt ttatttaggg aatacaaagg aaaaaacgat ttacttaacg tttgataacg 714421 gatatgaaaa tggctatacg ccaaaagtgc ttgatgtctt aaaaaaacat cgcgtaacag 714481 gaacgttttt tgtcaccggg catttcgtaa aggaccagcc tcagctgatc aaacgaatgt 714541 cagatgaggg ccatattatc ggcaatcatt cctttcacca tccggattta acgacaaaaa 714601 cagctgatca gattcaggat gaacttgatt cagtcaacga agaggtttat aaaattacgg 714661 gaaagcagga caacctgtat ttgcgtccgc cgcgcggcgt gttcagtgag tacgtactga 714721 aagaaacgaa acgcctcggc tatcaaaccg ttttctggtc ggtcgctttt gttgattgga 714781 aaatcaacaa ccaaaaggga aagaaatatg cctacgatca tatgatcaag caggcgcacc 714841 cgggagccat ttacctgctt cacaccgtat cgagggacaa tgcagaagcg ctggatgacg 714901 cgattacaga tctgaaaaaa cagggctaca cttttaaaag cattgatgat ctgatgtttg 714961 agaaagaaat gaggctgccg tctttgtaaa agagaaagac ctctccttaa acggagaggc 715021 ttttctttat tttatacatt taatcagtgc ggcccagtcc agatccccga agcctttctc 715081 aatcccgctt tcaaaatggc tcttggccag ctcggcaaga ggaagatttg cagaaacccg 715141 ttttgcggcg gcgagtgcca ggttggtatc cttcagccct aaagacattt tgaagccggc 715201 cggctcaaat ttctgctcgg ccataatggt tccgtaattt tgatagactg gagaaccaaa 715261 gagcgcgctg gcgatttcta aaaattgttt ttgttctaag ccgtatttct ccatcattaa 715321 aaaggattca gataacgcct ccagcatgga cacaagcaag aaattaatgc tgattttggc 715381 tgcatttgcc gtcttgcttt cttcgccgac gtcaaatatc tgctggctca ggctgtcgag 715441 cagaggcttg gcagcttgct ttgcttccgc cggtccggct gttatgatac ggagcgcggc 715501 tttggctgcg gcatccggtc tgccaaggac aggagcggcg agaaaaaatt gtcctttctc 715561 tgcatgagcc gctgcgagct tttctgagaa ctcaacactg attgtgctca tcgagatgtg 715621 tatgccgttc tctgctaatc cttcaagcag cccgtcttct ccgaatgtca cggtgctgac 715681 agaatcatca tctgcaagca ttgtgatgac aatatcagcg gactttgccg ccagccgcgg 715741 cgtatcagct gcctgtgcgc cttctgtgac aaggtcttct gtcttttgtt tcgtccggtt 715801 atagacagtc aattcgtagc ctgcttgaag aacatttcgg gcaatgggct gtcccatatt 715861 gccgagtccg atgacagcaa ttttcaatct aatcactccc tgaatatttt ttccattata 715921 aacaatatga acagaatatg catagcgatc ggcttacaac aaaaaagaac agctgctcgc 715981 tgtcctcatt taaaaatatt gaaccatcct ttatgtacaa accaaatcag cattccaatc 716041 acaagcgcgg ccatcaggcc aagtacagcg aaatatccgt atttccaatg cagctccggc 716101 ataaagtcga agttcatacc gtatacaccg gcaataaagg tgagcgggat gaaaatggtt 716161 gatacgatcg tcagtgtcat cataatcgca ttcatccggt ttgagtttag cgtcacgtag 716221 ctgtcacgca agtcggacgt catgtcacgg ttggattcca caatttcaga caactttaac 716281 aaatgatcat atatgtcgct gaaataggct ttcgtttccc gctgctcttt cacatggtca 716341 aggcttaaaa tccggtagag caaatcacgc atcgggataa tcgtccgtct caaatgcaat 716401 aggtctgttc tgagatcaaa cacctcgttc atcagcgttc catacgtttt gtggggacgg 716461 ctttcttcaa tttcattcag ccggtcttca attttataca cgagaggaaa atattcatca 716521 acaagctgat ccatgatcat ataagaaata tgcccgggcc cttttttcaa tatgtccggt 716581 gaagcataca aacgctcccg gactttagcg ataccgggcg tttcgtgtaa atgaaaggtg 716641 acgacaaatt tttcgccttg aaagatatcg acttcctccg tctcaagtgt ttccttattc 716701 agcgcatgaa tcacgtaaaa acgatagccg tcataatggt caagctttgg ccgctgcata 716761 tgctggaagc aatcctcaat ggcaagcggg tgaaaatgaa aaaaatctct caataacgcc 716821 gtttccgtat cctccgggcc gtaaaaatca acccagtacc atgcaatatc aggctgttcc 716881 actcgttcga tcggtatatt tttcagcagc tgatgctctg ttgtgattgc ggtaatgttg 716941 atcataaaca accctccacc tgccattata tcatgcggtc tttatgagaa aagtatacgg 717001 tactctctgc ctaattccag cggcatgtta tactgaacaa aaacggaaaa aagggtggat 717061 ctcatgtgga aggaaaaagt atctgtcacg cctccgtatc attttgaccg cgtgctggac 717121 aggctgtctt tagaccccct caatgctgtt gatcgagagg cgagggaagt ccgtgtgcca 717181 atcagaaatc aagcggggga cgtatgtatt gtaaaggtac aggcgttagg ccatgcgggc 717241 gagcctgagt tcctcgtcag cggggaaacg gatcagggag aaatgatgaa ggaaatcaag 717301 cggatttttc aatgggaaaa tcatttgcag cacgttctgg atcatttttc aaaaacgagc 717361 ctgtccgcca tttttgaaga gcatgccggg acgccgcttg ttctggacta cagcgtgtac 717421 aactgcatga tgaaatgcat tatccaccag cagcttaatc tttccttcgc ttacacgcta 717481 acagaacggt ttgttcatgc gtttggcgag cagaaggatg gcgtgtggtg ctatccaaag 717541 ccggaaacga ttgcggaact cgattatcag gatctgcgtg atctgcaatt cagcatgaga 717601 aaagcggaat acaccattga tacatcaagg atgatcgcag aaggcacact cagcttgtca 717661 gagctgccgc atatggcgga tgaagacatt atgaagaaac tgatcaaaat caggggtatc 717721 ggcccgtgga ccgtgcaaaa cgtcctcatg ttcggacttg gccgtcccaa tttattcccg 717781 cttgccgata tcggcctcca gaatgccatc aaacgccact ttcagctgga cgataagccg 717841 gcaaaggatg tcatgctggc gatgagcaag gagtgggagc cttatttaag ctatgcgtct 717901 ttgtatttgt ggaggagtat agaataattc gtctgacaat gaaggaaatc ctgcaaacgt 717961 gttatactag aaagatgtga aaaaaccatt tcactttctg ccatccgcag aaagcttcat 718021 atagaaacgg agagaacaac gtgaaccaac aaaagaaaca ggcgcccgtc gaactgaagg 718081 tcggacaaac ttttccgctg acgattaagc gtctcggcat taacggagaa ggtgttggct 718141 attttaagaa aaaagtcgtc ttcgtgcccg gcgcgcttcc tggcgaagaa gttgttgtgc 718201 aggccacaaa ggtccagccg aagttttcgg agggccgcat taagaaaatc cgcaaggcat 718261 ctgagcaccg ggtggcaccg ccttgccctg tttatgaaca atgcggcggc tgtcagcttc 718321 agcaccttgc atacagccag cagcttcggg aaaaacgtga tatcgtcatt cagtctcttg 718381 aacgccatac gaagtttaaa gttgaaaaca tggaaatcaa agaaacgatt ggcatggaca 718441 acccgtggaa ttaccgcaat aaaagccaat tccagatcgg gcgctcgcaa agcggcagca 718501 tcatcgccgg cttatacggc cttgattctc atgatatcgt gccgattaaa gactgtatcg 718561 ttcagcatcc ggcaacgaac aaaacaacag gcatcgtccg ccgcatttta gaggacttca 718621 atgtgtctgt ttataatgaa agaaaacgaa aaggcgacgt tcgcacgatc gtgacgagag 718681 tcggctttga aacaggcgaa gtgcaggtcg tgcttgtaac cgcaaaagaa acgcttccgc 718741 acaaggaaga aatcgtcaaa gcgattcaaa agcgattgcc agaggtcaaa tccattattc 718801 agaatgtaaa cggggcgaaa acctcagtga tttttggtga gaaaacaaaa cagctcgccg 718861 gaaaaacagt gattcaagaa gtgctcggcg acgtatcttt tgaattgagc gcccgcgctt 718921 tcttccagct caatccggaa cagaccgtca agctgtatga tgaagtgaaa aaagcggcgc 718981 agctgaccgg aaaagaaaaa gtcgttgatg cgtattgcgg cgtcggcact atcggcatgt 719041 gggttgcgga cggagcgaag gaagtccgcg gcatggacgt catcaaggaa tcaattgacg 719101 atgctaagaa aaacgccaaa aaacacggca tggcaaatgc cacatacgta acaggaacag 719161 ccgagcactg gctcccgaaa tggacgaaag aaggcttccg cccggacgtc gtcattgtag 719221 acccgccaag aacgggctgt gacagcacgt tcttggacac gatcaaaaaa gtcaaaccga 719281 aacgctttgt ctacgtttcc tgcaatccat ccacgcttgc gaaagatttg cagacgctgt 719341 cgaaggacta tcgcgtggac tatattcagc ctgtcgatat gtttccgcag acggcgcatg 719401 ttgaagcagt ggcgaggctt gtattaaaat cgtctaacta aaaagaacat ttcccagtca 719461 taaaatagtt ttcctaataa gacctggatt tcggtaaaat aaacaattcc gatttccggg 719521 tctttttcgt gcgcagctct tgtcctaacg gtctgttctc aattttatct tccttctttt 719581 cgcggagatc tttattttaa ctggcgaaaa gaattgaaaa aacgtgttga aaagcaggtg 719641 aaaaaaagcg ttatttaacc ggaaaaatat cctcccagta tgtttaaaat acatgagtag 719701 aatgatgtaa aatcatagat gtattttcat aatttgtaaa attatatatt gacttgcagt 719761 tattacgtgt gaaatattga tgataggaat ataaggaaag tatggcgtat atcatttcaa 719821 gagtcattcg atgtaaaaag ttgaaacatt gtaataaatg aaagaggtga aaatgatggc 719881 caaccccatt ttaaaatgca taacgtatga gcactacaac aattaaataa tagtgccgag 719941 acgataacaa ctattacagt aatacctaca atggttatat ccttgcgaca atcatgcttc 720001 ataatataat gattttagat tgacacttgg ctaaaaagta ttgcagagaa ggaaatggat 720061 aattaaatgg ataaagtata taaaagaagt tggtttcaaa catttttggc atttttagta 720121 tctcagcttt attttaattt tgtagaatta acgggatggg gtcctaagta tagagaaatg 720181 aatggattcc cagcaaacat agttgaacta gatttctttc aaacatatct ttcattctat 720241 gataatccat ggtttaatat tattactgtt ttcttgggag ttttcactat tatacaaata 720301 attacaggga taacaaagga tattcgaaat taaagcaata acttctgatg ccttatttaa 720361 tgatgaaaga aaatgtacac tttcttaatt atcttatgag tgaagactgc gacacttagt 720421 cagcagtcta ttttatggtt ctggatcagg attaccgaat tataacccta tacaaatata 720481 tagtaggttg ccacttgctg cgttggttat tttctaaatc atgagcaaat cccaaatgat 720541 tcagattgaa gttcttgaat tcttttaaat aagggtttat tttctcttct catcctcttt 720601 actccatgtg attcacaagt ggtagcagct taagtaggtt ttttcattct cttgagtact 720661 cagttatacc acccccaact caatttgctt tatctctatt agtttttccg caaatatgat 720721 atagagatac ggatatggtg tagtgttaaa tatcttatct tcaataacag ggcaattatt 720781 ttgcgttggt aatatggaga actcatatga tattctattt aggttggaat cctttttatc 720841 caaaaagttc aaaagcaagg ccactaagaa agacgaaggt cagcgccagt taaccagaat 720901 ataaaaaata gggtagataa tcatcccacg tgaaatcttc aaaatttact atagattgat 720961 aagaaatgct ttcgcatgcg ataagtgtaa aagaagcatg gtcagttttt aatttgggat 721021 aaaggttcag ccgtatccca taatgaaagg atttgatttt tgttatgaca gaaaatttct 721081 ggcgtgaatt accacggccg ttttttgtac tggcaccaat ggaagatgtg acagatgttg 721141 ttttccggca tgtagtaagt gaagcaggca gaccggatgt gttttttaca gagttcacaa 721201 actcagagag ctattgccac ccggatggga aggatagcgt gcgcggccgt ttgactttta 721261 cagaggatga acagccaatt gtggcccata tatggggaga taagcctgaa aacttccgta 721321 aaatgagtat tggcatggca gagttaggat ttaaaggact agatatcaat atgggctgcc 721381 ctgtgcctaa tgtggcgggg aatggaaagg gaagcggcct tatttgccgt cctgcagttg 721441 cggcagaatt aatacaagct gcaaaagcag ggggattgcc tgtaagcgtg aagacaagac 721501 ttggatacac ggatgtggat gaatggcgcg agtggctgac acacattttg aaacaggata 721561 ttgcgaatct ttctattcat ctgcgtacaa gggcagaaat gagcaaagta gatgcgcatt 721621 gggagctcat cccagagatt aagaaacttc gtgacgaggt ggcaccagat acattgctaa 721681 caataaacgg ggatattcct gaccgtcaaa ctggcttgaa acttgctgaa caatacggcg 721741 tcgatggaat tatgataggg cgcggtattt ttacaaatcc tttcgctttt gaaaaggagc 721801 cgaaagagca tagcagcaag gaattgcttg atctcttaag gctgcatctg gatctccatg 721861 atgaatattc aaaagaagaa gcccgtccat acaagcctct tcctcgcttt ttcaagattt 721921 atctccgcgg attccgaggg gcaagtgaat taagaaatca atgcatgaac acaaagtcaa 721981 cagatgaagt gcgtgcattg ctcgacgact ttgagagaaa gtatcttgat gggatagagt 722041 aacagcagtg cttgattcaa aaaaggctaa caaaataaag ggatttttac acaattcttg 722101 actaaaataa acctggattt tcggtaaatc cgggtctttt ttgtacgcag cttttactca 722161 gcctgtcttt tctctaattt attgtaagaa aataatggta tatttagtgg agatatcata 722221 taaaggggga gaggaaaatg aaacggctat gcatcatccc ctgcggcaag aaaaaaatct 722281 gggatgtcca gcctgatgcc gggccggtaa gagcagagga cgcttatctc agcccgtttc 722341 atcaggcgtg cgagcggtat gcaaaaacat ttttcgatga gtgggtgatt ttgtcggcga 722401 agcacgggtt cctccgccct gatgatctcg tttcgggaaa ttacgatgtc acttttggca 722461 ccggtcatcc ggaaatcatg acagcggacg agctgcgccg tcaatttcac gaaaaaggct 722521 tttctgatat cgaagagcta gtcatgcttg gcggaaaaaa atatcgaagc gttctaaacg 722581 ccgtcatcgg agaacaccag catatcagct ggccgctatc atcatacaaa ggcataggct 722641 atatgctcca agcgctgaac cgggctgttg aagaaaagca tgaactgtag cacgtacata 722701 tgaggaaaag agtgggaaca tgaaaaaact tgtgtttggc ttgcttgcca ttgtgttatt 722761 cggatgcgga ctatatatct atcatgtatg gttcggtgat ccattttcga aaaatgctgc 722821 agaacagaag ctagtgtctt atgtgaaaca aacctatcct aagaaagaaa tcaagatcac 722881 gaatggggta tataacgcta aaacgtctga atatgtattt gaagcaacct cccaatctca 722941 tcgctaccca atgtgtacga agggatttct gcatcctaaa gtaacgtgcg atggaattga 723001 agaagcgtat accgaatcag tagcaaaaca tgtaaatgaa gaagcaacga aggcaatcga 723061 agcagatctg aaaaaagcgg ttcctcgatt tataaaagct gatgctgctt tgagtatcga 723121 aaacggacag ttcacgttag atacaaaatg gaacaaaaag ctggctgaaa aagcgcctat 723181 gagcatgacg attcagttag acgccagcgg gttatcaaaa acagatgccg caaagatggc 723241 ggaaacggtc agaaaaacgc ttaatgaaaa gggatataca tactcaaacg gcacgataga 723301 ctgtatgcag aaggacgggg acggcggtat tggatatgtc aaatattcaa ttgattttct 723361 ttcaaaagca gctattcagt caaacgatgc agaggaacta ggaagttaaa aagatttcca 723421 aggaaataaa tacgtcgatc attgtcaaag gccgggtgat atccggtctt ttttttgcat 723481 gctgtaaaac gagacaaatg aatcagtttg agacaaaacg agacacacgt ctcaaactgt 723541 ctccaaagtg aagatgagaa gactgatttt acgggctcaa aagactggca cacttcttgc 723601 atttataatg gtgaacccta aatagaagga ggcgcacaaa atgaaattgt taaaacgaga 723661 aggcttgtca ttaactgagg aaaaagcgct gtggatgtac caaaagatgc tggagatcag 723721 gggctttgaa gacaaagtgc atgaactgtt cgcccaggga gtgcttcccg gattcgttca 723781 tttatatgcc ggtgaggaag ccgtggctgt aggggtgtgc gctcatttac atgatggcga 723841 cagcattaca agcacccaca ggggacatgg acattgtatc gccaaaggct gtgacctgga 723901 cggcatgatg gcggaaattt tcgggaaagc gaccggattg tgcaaaggca agggcggttc 723961 tatgcacatt gcggatcttg ataaaggcat gttaggcgca aatggaatcg tcgggggcgg 724021 ctttacgctc gcatgcggat cagcgctcac ggctaaatat aaacagacta aaaatgtaag 724081 cgtttgcttt ttcggggacg gggcaaataa ccaaggtacc ttccacgaag ggctgaattt 724141 agcggctgta tggaaccttc ctgtcgtatt tgttgctgaa aacaacggct atggcgaagc 724201 taccccattt gagtacgcat cagcctgtga ttcaatcgcc gatcgggcgg ctgcttataa 724261 catgccgggg gttacagttg acggcaaaga tattttagca gtttaccagg cagccgagga 724321 agcgatagaa agagcaagaa acggcggcgg cccgtctttg attgaatgta tgacctacag 724381 aaactacggc catttcgaag gagatgccca aacctataaa acgaaggatg aaagagttga 724441 gcaccttgaa gaaaaagatg ccattcaagg ttttaaaaac taccttttaa aagaaacaga 724501 tgctaataag ctgtcagaca ttgaacagcg tgtcagcgaa tcgattgaaa aagccgtctc 724561 gttcagcgaa gacagcccat atccaaaaga ttcggagctg ctgacagatg tgtatgtgtc 724621 atatgaaaaa ggaggaatgt aagagatggc gagagtcata agcatgtcag acgcgatcaa 724681 tgaagcaatg aagcttgcga tgagaaaaga cgaaaatgtg cttttgatcg gtgaggatgt 724741 cgccggggga gcggcggtcg atcatttgca ggatgatgaa gcatggggcg gtgtattagg 724801 ggtcacaaag ggactcgtac aggaattcgg gcgtacaaga gtgctggaca ctccgatttc 724861 tgaggcaggc tatatgggag cggctatggc tgcggcatca accggtttga gaccgattgc 724921 cgagctgatg tttaacgatt ttatcggcac gtgctttgat caggtgatca accaaggggc 724981 gaaattccgt tatatgttcg gcggaaaagc gcaagtgccg attaccgtcc gcaccacata 725041 cggagcaggg ttccgggccg ctgcccagca ttcacaatcg ctgtatggcc ttttcacgag 725101 catccctgga ctgaagacag ttgttccatc caatccgtat gatgccaaag gtcttttgct 725161 tgcagcaata gaagataatg atccggtgtt tttctttgaa gacaaaacgt cctacaacat 725221 gaagggcgag gtgccggaag attattatac aattcccctc ggaaaagcgg atatcaaacg 725281 cgaaggcaat gatgttacgc tctttgcagt cggcaagcag gtcaatactg cgcttgaagc 725341 ggctgcacag ctttcagaga ggggcatcga agccgaggtc cttgatcccc gcagtctgtc 725401 tcctctggat gaggatgcga ttttcacatc gttagaaaaa acaaaccggc tgatcatcat 725461 tgatgaagcc aatccgcgat gcagcattgc cacggatatt gctgcgcttg tcgctgacaa 725521 gggctttgat ttgcttgatg cgccgattaa acggattaca gcgccgcata caccggttcc 725581 gttttcacca gtgcttgaag atcaatattt gccgacacca gataaaattg tcagcgtcac 725641 gcttgaattg cttggcgagc cggcattgaa ttaaaggggg gacacaaatg gcggtaaaag 725701 tagtgatgcc aaaattggga atggccatga aacaagggga agtatcgata tggaataaaa 725761 aagtaggcga cccggttgaa aagggagaaa gcattgccag cattcaatcg gagaaaattg 725821 aaatggagat cgaagcgcct gaaaaaggaa cgctgatcga tatcaaagtg aaagagggag 725881 aagaggttcc gcccggcaca gctatctgct atatcgggga cgccaatgag tcggtgcagg 725941 aagaggcggg ggcgcctgtt gctgaagaca atatgccgca agccgtccag cccgtcaaac 726001 aagaaaacaa acccgcagcc tccaaaaaag atcgaatgaa aatatctcca gtcgccagga 726061 aaatagcaga aaaagcagga ttagacctaa aacaactgaa aggaactgga ccaggcggac 726121 gaatcgtgaa ggatgacgta acaaaggctc ttgctgaaca gaaaaaagat caagcaaagc 726181 ctgtttcgga gcagaaagcg caggaaatcc cggtgacagg catgagaaag gtcatcgctg 726241 cccgaatgca ggaaagcctg gcaaacagcg cgcagctgac gatcacgatg aaagctgata 726301 tcaccaagct tgccactctt caaaaacagc tttcaccaac tgcggaagag agatacggca 726361 caaaactgac gatcactcat tttgtctcaa gagccgccgt tctcgctctg caagctcacc 726421 ctgtgctgaa cagcttttat caaaatgagc gcatcatcac acatccccat gtgcaccttg 726481 gtatggctgt agccttggaa aatggcttag tggtgcctgt catccgccat gctgaaaagc 726541 tatcgctgat tgaactggct caatccatct cagaaaatgc caaaaaagca cgcgagggac 726601 gtgcgggaag cgaagaactg caaggatcta ctttctccat tacaaacctt ggcgcgtttg 726661 gagttgagca tttcacaccg atactaaatc cgccggaaac aggcattctc ggcatcggag 726721 caagctatga cacaccggtg tatcaagggg aggagatcgt cagaagcacg atcctgccac 726781 tcagcctgac atttgatcac agagcgtgtg acggcgcccc tgccgctgca ttcctgaagg 726841 cgatgaaaac atatttggaa gaacccgcag cattaatttt ataggaaaag caggtgaaaa 726901 cgacatgaca ttagccatta tcggcggcgg acctgcaggc tatgcggctg cggtttccgc 726961 ggcacagcag ggcagaaacg tgctgctcat tgacaaaggc aagcttgggg ggacctgcct 727021 gaatgaaggc tgcatcccga caaagtcttt gttagaaagc gcaaacgttc ttgataaaat 727081 caagcatgcc gacagctttg gaatcgaact tccggcaggt gcgatatcag tcgattggag 727141 taaaatgcaa agccgaaaac aacaggttgt cagtcagctt gtccaaggcg ttcagtacct 727201 aatgaagaaa aatcaaatac aggttgtaaa gggaacagcc tcctttcttt ctgaaagaaa 727261 gctcttgatc gaaggagaaa acggaaaaga aatcagagag gcggaccaag tattgattgc 727321 ctccgggtca gagccaatcg agctgccttt tgccccattt gacggcgaat ggatcctcga 727381 cagcaaagac gcgctttctc tttccgagat tccgtcttca ctagtcattg tcggcggcgg 727441 tgtcatcggg tgtgagtatg cagggctgtt cgccagattg ggatcgcagg tgaccatcat 727501 tgaaacagcg gaccggctga tcccggctga agatgaagat attgcccgtc tctttcagga 727561 gaaacttgag gaagacggtg tcgaagtgca tacttcatcc agattagggc gggtggatca 727621 aacggccaaa acggcaatat ggaaaagcgg tcagcgagag tttaaaacga aggccgatta 727681 tgtgctggtg gcgatcggca gaaaaccccg tcttgacgga ttgcagctgg aacaggccgg 727741 agttgatttt tctccaaagg gcattccggt gaatgggcac atgcagacga acgtgcctca 727801 tatttacgcg tgcggagatg ctataggggg cattcagctc gcgcatgccg ctttccatga 727861 gggcatcatc gctgcttctc atgcttccgg aagggatgtc aaaatcaatg agaaacatgt 727921 gccgcgctgc atctatacgt ccccggaaat cgcgtgtatc ggaatgacag aacgacaggc 727981 aagaagcata tacggggatg tgaagatcgg cgaattttca ttttccgcaa acggcaaggc 728041 gctcattaaa cagcaagcgg aaggaaaggt caaaatcatg gctgaaccgg aattcggcga 728101 aatcgtgggt gtctcgatga ttggcccgga tgtaaccgag ctcatcggcc aagcggcagc 728161 gatcatgaat ggtgagatga cggcagatat ggcggagcat tttatcgccg cccatccgac 728221 tttatcggaa acattgcatg aggcgctgtt aagcacgatc ggccttgcgg tacatgcata 728281 ataaaggaaa aagcaggcgc atggatataa ggcgcctgct tttttattgt tgaaagcgct 728341 ttatttttcc cctacaatag atgaaaacgg cgtgtaaggg aggagcgatc aaggaaatga 728401 attcggtccc aaacgatttg caaacctgga aacgttttgt gaaagacggt gtgcttgacg 728461 aagcccgatt aagaaaacgg attgcagagt catggcatcg ctgcaaaaaa gctgaggtca 728521 atccttattt agaaaaaggc ccgaaggttt tacagcaaac ggagctggat cagcagtcaa 728581 aaaaacattc attcttcttg acgaccgcaa agccttacct cgaaaaactg ctgcctgcca 728641 taaaagaaat ggaaatgatg gcgctgttaa ttgattcaga cggtgttgtt ctggcattgg 728701 acggccatcc gcgcgcgctc tatgaagcca aacgcatcaa tttcgtcgaa ggggcatgct 728761 ggacagaaac ggctgtcgga acaaatgcga ttggcacggc gctccacatc agcgagccgg 728821 ttgcaataca aggatcagag cattactcta tcgcttccca tctttggaac tgttcagctg 728881 ctccgattca ccatgaggat ggcagccttg cgggtgtaat tgacatatca tgcccggcgg 728941 caggcgcgca tcctcatatg cttggtattg ccacggcgat tgcctatgcc gctgaacggg 729001 aactcgcagc taaaagccgt gagaaagagc tggagctgat cagccgtttt ggggagagag 729061 ctgcatccag tgtgccgatg gtgctctgta ataccaagca gcacatcatc agtgcgagca 729121 tgccgattcg aacctcaatg ccggattggc agggccggca cctgtacgag ttgaaggaac 729181 ggggctattc aatcgaaaat gctgtcacca taggagatgg cggcacttgt ttttatcttt 729241 cggaacaaaa gaaaaagaag gcgtttcgat tcaatggagt gatcgggcaa agcggccgat 729301 cgcaagcgat gctgatgcac cttgaacgag cagctgcgac ggatgcatcg gtctgtttgt 729361 cgggtgaaac gggtacgggg aaggaggtcg cggctcgcgc gcttcatgag aacagtgaga 729421 gacggcacgg tccgtttgtt gctgtcaatt gcggagcgat tccgtctgat ttgattgaaa 729481 gcgaactgtt cggatatgca gagggcgctt ttacgggagc gaaacgaaat ggctataaag 729541 gcgcctttca aaaagcgaat caaggcacat tatttttaga tgaaatcgga gaaatttccc 729601 actcgatgca ggttgcactt ttacgggtgc ttcaggaacg caagataacg ccaatcggcg 729661 ggacgaaaga aattccggtt gatatcagag ttattgccgc cacacattgt gatttacgcg 729721 agcttgccga aaacggaaaa atcagagagg acttgtttta ccgtcttcat gtctatccaa 729781 ttgaactccc tccattacgc gatcgcaccg aggatatccc ggatctcttt gagtactaca 729841 aacagaagaa tcattggcca ggcgatcttc cttctgattt ttgtaatgtg ctgaagcaat 729901 ggaagtggcc ggggaatatc cgcgagctgt ttaatgtgtt tgaacgtctt tctatcagat 729961 ttccggacgg ccggctgaga gatgaatcgc ttcccgcttt actggaagcc gctggattgc 730021 cggccagctc tgcagaaaaa aagccggctg ctgccggcgt gcttactttt cgtgagcaaa 730081 tccaaaagga tatgatgatc aaagcgcttg aatctgcaaa aggaaacgtc tctcaagccg 730141 caaaaatcag cgggatcccc cgaagcactt tctacaaacg cctgaaaaaa ttcaacttgt 730201 ccgctgaatc ataaagcata cttccgaatt ccactcctga aagaaagtga gcagaaaccg 730261 catgcgggac tttgtccgaa aaataacggt agtgtataat gagttggaga ttattggggg 730321 agaggatcga actagaatat gattggagag accattgctg attaaaaaga atgctttatc 730381 aatattaaaa atcgtttttc ctattgctgt tttgctattt gttatttatc aatcgaaaaa 730441 agaactgaca aatctgtcat tcaaacgtac gctcatggtc atcaacggac tggaacgaac 730501 ggatttattc atgcttgtgt tgatcggctt gctggctgtt gcggctatgt cgctgtatga 730561 ttacgtcctg aagtactcac tgcgcctatc gatcacaaac ggaaaagttt tcagggtttc 730621 ctggatcgcc aattcattta ataatgtgtt gggattcggc ggtttagccg gagtcgggtt 730681 aagaatgatg ttctataagg agcatacgaa agaccataag gcactcgtga aaggaatcgc 730741 ctggctcaca tcatctatgc tgctcggatt atctgttttc agcattttcg ttgctgcgag 730801 agtgctgcca gttgatgaag tgattcatga gaagccttgg ctgtgggcgg tcgttatcgg 730861 ttttgcactg atattgccgt tatctttagc ggtgtccaaa ataaaagacc gcaaagctgg 730921 ggacgaagag aatgcggata aagtgaaaaa tccgattttc gcatatattg gagcttcagt 730981 tgttgaatgg ctcatggccg ggaccgtcat ctattttgct ttgttcgcta tgggcattca 731041 tgcagatatc aggtatgtgt tcggggtgtt cgtcattgcg gcgatcggag gaatgatcag 731101 cctcgtgccg ggcggcttcg gctcgtttga ccttttattt ttgctgggga tggagcagct 731161 tggctatcat caagaggcca tcgttacttc tattgtgttg tacaggctcg cctactcatt 731221 tatcccattt atcttgggac tgttctttgc cgccggcgac ctgacggaaa atacaatgaa 731281 gcggctcgaa acgaacccgc gcatcgcacc ggcaattgag acgacaaacg ttctgcttgt 731341 tgttcagcgt gcggtattag tgagaatttt gcaaggctcg ctttccctta ttgtgttcgt 731401 agcaggtctg attgtcttgg cctcagtttc cttgccgatt gacaggctga cggttatacc 731461 gcacattccg cgcccggcgc ttttgctgtt caacggcctg tccttaagct cagcgctcat 731521 tctgctcatt ttgccgatcg agctttataa acggacaaaa cgttcctaca cgatggccat 731581 tacagcgctt gtcggcggct ttgtgttcag ctttttaaaa gggcttaaca tcagcgcgat 731641 attcgtactg ccgatgatta tcgtattgct tgtgctattg aaaaaacaat ttgtccgcga 731701 acaggcatcc tatacactgg gacaattgat attcgctgtg gcgctgttta ctgtggcgct 731761 ctttaactac aatctgatcg cgggctttat ttgggaccgg atgaagaagg tgctgcgtca 731821 cgaatatttc gtccacagca cctcgcatat tacacatgca accatcatgg cgatcatcat 731881 tgtgccgctg ttcttcttga tatttacagt ggtctatcat aagagaacga aaccgatcgg 731941 agagaaagct gaccctgagc gtcttgctgc gtttctcaat gaaaaaggcg gcaacgcgct 732001 gagccatctt ggttttcttg gagataagcg gttttatttt tctagcgatg gaaatgcact 732061 gcttctgttt gggaaaatcg ccagaaggct ggtcgtgctc ggcgatccat ctggccaaag 732121 agaatcattc ccgctcgtgc tggaagaatt tctgaacgaa gcgcatcaga agggattcag 732181 tgttttgttc tatcaaattg aacgagagga catggcgctg tatcacgatt ttggctacaa 732241 cttctttaaa ttgggtgagg aagcatatgt agatttaaat acatttacct tgactgggaa 732301 gaaaaaagcc ggccttcggg caatcaataa ccgctttgag cgggaggagt atactttcca 732361 tgtggatcat cccccatttt ctgatgcgtt tttggaggag ctgaagcaaa tctcagacga 732421 atggctcggc tcgaaaaaag agaagggatt ctcgctcgga ttttttgatc cttcctattt 732481 acagaaagcg ccgatcgcct atatgaaaaa tgcagaagga gagatcgttg cattcgcaaa 732541 tgtcatgccg atgtaccagg aaggagagat atcggtcgat ctgatgcgct atcgcggcga 732601 cgctccaaat ggcattatgg acgcattgtt tatccgtatg tttttatggg caaaggaaga 732661 gggctgtacg tcatttaata tggggatggc acccttggcc aatgtcggca ctgcctttac 732721 atccttctgg tccgaaaggt ttgccgctgt catttttaat aatgtcagat acatgtacag 732781 tttcagcggc ctaagagcct ttaaagaaaa atataaaccg gagtggcgag ggaaatactt 732841 agcgtatcgg aaaaacagat ctctttctgt caccatgttc ctcgttacac gtctgattgg 732901 caaaagcaaa aaagactccg tctaataaga cggagtcttt ttttatttcg tttttaagaa 732961 gtaggtttca atatcatcaa gcaggtagtt tgcggcttta attccgcctg cggttgtcca 733021 tacgacgtca tcgacttcat gtgcattacc tgacttcacg gccttcaggt ttttccatag 733081 tgaactgctt gtccactgat tggcccattt ttcattttct tttgcattat cggctttata 733141 agtgaaataa aacagcacat cagcatccat atcaggaata gattctttac tgtcggttga 733201 gaacgtaaat tggtcctttt gtttcttaaa cagttccact tgtttttcag ggcgtttgaa 733261 gccaagctgg tctaaaataa tcccaggaaa tgaatcggta taatagattc ttgattcacc 733321 ggataaaaag cgtacgactg aaacggtttt gtttgtctgg tcgcccagct tgttttttaa 733381 atcagaaaca cgtttatcaa aatcggcaat gacttccttg cctttgtccg ccttattcac 733441 cgcgttggcg tatagagtca ggttatcctt ccagttcccg gccaaagatt cagcaaaaac 733501 agtcggcgca atcgcattta actgatcata aattttttcc tggcgcactt tgtttccaat 733561 aatcaaatca ggctttaatt ctgcgatggc ttccacattc ggttccgttt caagaccgac 733621 gtttttaaca cctttcatgt catctttcag atagtcatac cacgggtcgc ccttccatga 733681 ctttacggct ccgaccggct taatgccaag cgctaagagc gcctctgttc cttcattagt 733741 taaaacaaca atccgttttg gattggcggg gatgttgtct gatgtcccca ttgcatgttt 733801 gaccgttctt gttttgctgc ttgacacctc gctgttgctt gaactttctg aactattaca 733861 ggcagaaagt accataacgg ccattaaaaa tacgaatagc atgctgatat gctttttcat 733921 ctttttcctc ccaatattga aattcattat catttagatc ataataagca gtgttaagag 733981 tgtcaatccc taattgagga ttattctcaa aaacaaacat tacatagtaa ataactagga 734041 gaattagatc atgatctgca aaaaggcatc ttcaaaatgg attgtgttag tatgtctgat 734101 tttcatttta ctgacggctg tctgcgcaag cgtcgtgtat ggctatacag gtacgtcatg 734161 gagacaggtc tatcaggcgt ttacttcctt caatggaaca aatgagcatg tcatcatcaa 734221 ggatgtcagg cttccgcgcg ctttggttgc gacagtcgtc ggcgcctcgc ttgcagccgc 734281 gggcgctctc atgcaggcgc tcacaaaaaa tccgcttgcg tcaccgggga ttttcgggat 734341 taacgccggt gcaggttttt ttattgttgc cggatcgttt tttctgcata ttcagtcacc 734401 tcaggcatta gtatggagct cgtttctggg ggcagcattt accgctgcga tcgtctatgc 734461 agcaggctcg cttgggaggg aagggctgac gccaatcaaa ctgacgctgg cgggagctgc 734521 catggcagcc atgttttctt ctctgacaca gggcttgctg tctgtcaacg aactcgagct 734581 tgcccaggtg cttttttggc tgactggctc tgtgcagggc cggagtctgg atctgttgat 734641 gacgatgttt ccatatgcag cggcagcgct ggtaatctgc ttctttctcg gccaaaaaat 734701 taatctcctc gttatgggag aagatgtggc aaaaggactc ggccaaaaaa caggcctgct 734761 gaaatttgtg atggcgcttt gtgttgtcat gcttgcaggg tccgctgtcg ccattgccgg 734821 gccgatttct tttatcggca tcattattcc gcattttgcc cgctttgtcg ttggtaatga 734881 ttatcgctgg gttctgccat tttccgctgt tttgggtgcc attttgcttg tttgcgcgga 734941 tatcggtgcg cgatatatca ttatgcctca ggaagttcct gtcggggtca tgaccgccat 735001 catcggaatg cctgtgtttg tgtacatcgc aagaaggggg gcgaagctat gaaacttcgt 735061 tttggcgtta ctgcggctga aaagaaagca tggatcgtct ttttggtttt actggggtta 735121 acagctgctg tactcatcat aagcgctggt ctcggacaaa ggtttattcc tccctgggat 735181 gtagcaaaaa cattctttgg tgcaggttcc aagctggatg aactgatgat catgtcgttc 735241 cgcatgccaa gaattttgac ggctttatgc gccggtgtct gcttggcagc ggcaggcgcg 735301 atattgcagg ggctcgtcag aaaccctctc gcatctccgg atattatcgg aataacagga 735361 ggagcggcgg tagcggtcgt gcttttaatg atgttcttct cagaccgcag cagttcactt 735421 acgatcagtc tgtcatggct tccagcagcc gcatttatcg gcgcatcggc tgtcgggctc 735481 atcgtctatt tactggcata caaaaatggc gcctccacat ttcggctggt gcttatcgga 735541 atcggatttt caatgtcggc gcaggcgatg actaccctgt tgatgatcaa aggcccgatt 735601 taccgagcat cacaagccaa tgtgtatatc actgggtcag tttatgggtc aaactggcag 735661 catgtaaaaa tagctattat cttatctgtc attctcttat tcatttgttt tgtcgcgcta 735721 aaaaatatga atatacaggt gctgggtgaa gatattgcgg cgggtgcagg aagcgctgtg 735781 cagcgaaatc gttttttctt gctccttttg agtacggctc ttactggttg tgcagtttca 735841 gttgccggca caatcggttt tgtcgggctg atggcgcccc atattgcaag acggcttgtc 735901 ggctcatctt atggcgcgct gctcccagcg tcggcactta ttggagctct gctcgtttta 735961 acagctgata tcgtcggcag aaccttattt gctccggtgg aagtgccggc cggcgtcttt 736021 acagcggcta tcggcgcacc ttattttatt tatttgctct ataaaacaag aaattcttaa 736081 tcgttacacc cattttctta aaaaagaaaa tgggtttttt tgataatgac tgaagattcg 736141 taattatttt tgctatactg acagagacat tgataaagaa agggcggcag atgaatgaaa 736201 gaagcagagg tattaaaata tgaagcattt acaagcagtc ccggcaaagg aaaccccgca 736261 ggcgtcgttt tgcagggaga cgattatacg gaagacgaga tgcagatcat agctgaacgt 736321 gccgggtatt cagaaacctc ctttatccga aaaagcgagt cggccgatct tgaactccgt 736381 tactttaccc ctggacacga aatgaatttg tgcggtcatg cgacagttgc ttctctttac 736441 gcattatgtg agaaaggaat gctggagagc ggtaaaacgt acagcatcca aacgaaagcg 736501 ggtatcctgc ctgtgaagat ttctgaaaaa gatggccgca ttcatatcac gcttgaacag 736561 gcctctccgc aattcaaacc atttacaggc gatcggaaaa aacttgcgga cgcactgggt 736621 atcaccgatg aagattttca tgaagacctt ccgattgtgt ttggcagcac tgggatatgg 736681 acagccatcg ttccgcttaa atcattggag gcttccaaaa aaatggtgcc agataacaaa 736741 caatttccgg aagtgttagt tgatctgcca aaagcttcag tccatccgtt tacctttgaa 736801 accgtccatc ccgacagcga cctgcacggg cgccactttt catccccgta ttcgggaacg 736861 attgaagacc ccgtgaccgg cacagcatcc ggcgtgatgg gggcttatat gaaacattat 736921 ggcaatgccg agcagcataa atttatcatt gaacaagggc aggaaattgg aaaagacgga 736981 aaagtggaga tcgaaatgaa cgaagccggc ggccatgtga aagtgaacat gacaggaaca 737041 gccgtttact cagaaacccg tattcttaaa atctaatacg gatgatggtt tacaaaaaga 737101 tgcactttcc gttatcatta tgaaatgata atcattttca attgcatagg aaggtgagac 737161 ggtatgcctc aaaccgaaca aatacatcag cattcagtac tgagggacat catacgcagc 737221 agaagatcga ttcgaaagtt taaacaagag ccagtacctt cagcagtcat tcttgacatg 737281 cttgaaacgg caaaatatgc gccaaatcac agagtgacag agccatggag atttatttac 737341 gtttccagtg agacaggtaa agcgaacctc attaatacat ttgcagcgtt ctctaagaaa 737401 tccaagccgg atatgacaga ggaaaagctt caaaatttca aaaacacact tgggcgcgtt 737461 ccgggatttc tcctcgtcgt gtttcaggaa gatgaaaacg aaagagcgcg ggacgacgat 737521 tttgcggcaa caagctcgtt gattcaaaat cttcagcttc tcgcttggga aaaaggaatc 737581 ggcatggttt ggaaaagcgg aaaaatcctt tatgacaaag aagtccatca ggcctttggt 737641 ttacaggata atgagcgttt cgccgccatc atacaaacag gttatcctga cgaggcgccg 737701 gaagtgaaaa aacgcacacc gatccgcgac cgattcactg aaatgtaaaa aaccccttgt 737761 ctcaaacgga gacaaggggt ttttcattaa cgagatttct ttttcgctct gttgtcggct 737821 gctttcgcac gctcttgcgc ttcgcggtca tctgcatcag caagctcggt tgaatattct 737881 tcgtaaacgc cgtcagtttc cctttttaag gcatcgggaa cttgtggaag cttttgtttg 737941 tttttatcac ggtttttgtg gatatgattt ctgcccatat caaattcccc ctaaaaagtg 738001 atatcaaaca aatatagtat ttggttttaa ggggctatgt attcctactt ccgcttagca 738061 gctttttccg cttttttaaa ttcgcctgaa taaagaactt cctgcatttt tttcaggttg 738121 gcgccttgct ggtgcttctc cctctttttt tccataaaaa ggacctcctt caaccatgtt 738181 attcttaagg ttgacgcttc ctgctgtttt tatacagtct ttcggtccgc tatcagctgt 738241 gagagtgcaa attcaagatc cgaatatgta aaacgaaatc cagaggttat cgcttttttc 738301 ggaagagcgc gctgtccttt cacaatcaaa agactcattt cacccaatgc ttttgataaa 738361 aagaattccg ggacggggag ccagtgcggg cggtgcttca cccgtgcaat cgtttttccg 738421 aattgcttca tgtccacagg attgggcgcg gtgacattca ttgggcctga gatgccggcg 738481 ttttccaccg catatcggat catctgggcc gcatcctcga catgaatcca tgacagccac 738541 tgccttcccg ttccgatcgt tccgccggcc agaaacttat aggggagaat catgagcggg 738601 agagcgcctt tttctccaag catcacgcca aatctcgcat aaactgtccg gatgcccatc 738661 gcttcaatat gctgtccttc cttttcccac aggtgtgcag tatggctgag aaaatcctca 738721 tctgacgttg cagaatcctc tgtgaaagtt ttctcaaggc ttgtgccgta aatgcccacg 738781 gcactggctt ggatcaatgt cttcggcttc tccttctgtt tctgaataag ccgctgcact 738841 tcacgcgtcg cattgatacg gctggagaga atgtgctgct tcgttttttc tgtccagcgg 738901 ccaaaaatcg attttcccgc aagatttatc cagacatcaa tatgaggaag ttcctgctcc 738961 ggtgcggctc cttccgacag ccattggaca tatgtcatat ttttttgttc agtttccctt 739021 gcgtttcttg ataaaatata aacatggtgt ccctggcggg taagaacgcc tgtcagatgc 739081 tggccgagaa aaccggttcc gcccgtcatt gcgatattca tgaacatctc tcctcatcgt 739141 tctaataaat atactttacc tcattgtaat aaaagaaaac gcgtttcagg cctgagaagg 739201 gagattaaga tgccgtttat tacaaaaata tcaacgcaaa aaaagaatac ggaacgcttc 739261 aatatttttc tggatgataa atacgccttc agcgtggacg cggatgtgct cgtgaaattt 739321 gagctcaaga agggaaaaga actcgatgat cttgacatca ttgagattca atacggcgat 739381 gaagtgaaga aaggcttcaa ccgtgcgctt gactttttat cctatcgaat gcggtcgacg 739441 aaagaggtcg aggatcactt aaagaaaaaa gaaacctcgc cccccgtcat tgcggaagtc 739501 atccataggc ttaacgatta caagtactta aacgaccagg aatttgccgc agcctatgtc 739561 agcactcaca aaaaaacaaa cggaaaaggc cctgatgttt tgttcagaga gctaagagcg 739621 aagggaattg atgacgatac aattaaggag gcgctaagtt ccttttcctt tgaagatcag 739681 acaagagaag cggtcaagca tgttgaaaag cttctcaaaa aagataaaaa gctttcgacg 739741 aaagaactca aacagcgcgc ccagctgcag cttcagcgca agggcttctc atttgatgtt 739801 atcagcgcgg cgatggatca gattgaatat gaaaatgatg aagacacaga gaaagaagcg 739861 ctgcgccttc acgcggaaaa agcgtttaga aaataccgct atgacggctc atatgaaagc 739921 gccatgaagg tcaaacaatt tttattccgc aaaggattct cactcgattt aatcgagcaa 739981 ttactgcagg aagaggagta ctgaaatgga gaaacgatac agtcaaatga caccgcatga 740041 actcaatacc gaaatcgcat tactttctga aaaagcaaga aaagccgaac agcatggaat 740101 cataaacgaa ctggcagtgc tcgaacggaa aattacgatg gcaaaagcat atttgctgaa 740161 cccggaagat tactcaccgg gagaaacata tcgtgtggaa aacactgagg acgagtttac 740221 catcagttat ttaaatggcg ttttcgcatg gggatacagg acctcttccc ctcagcaaga 740281 ggaagcgctg ccaatctcag tattgcaaga aaaagaataa agcgtaacag gaggctgatg 740341 atcagcctct ttttgtttgc agcacattta cacgaattct taaagaaaaa atcattgaat 740401 tcacttgaaa aatcttttaa gatgaaactc gttgtttttt aaaatcaaag gaggcgatga 740461 cgttgagtat caaaaaccca tctgtaaaat ttattatatt tgttcttatg atttgtacat 740521 tttcaatcgg ctatacagaa tacgcggtga tgggtatttt gacgtcgatt gccaatgact 740581 ttcatataca ggtttcatcc gcagggcttc ttgtcacggc ttatgcggca agcgtttgtt 740641 tgacagggcc gctcgtcacc atcatttccg tcaagcttcc gagaaagcct gtgcttcttg 740701 ggctgatggc gatatttatc ctttccaacc tgatgagcgc actggcgccg aattttgcgg 740761 tattggccat ttcaagaatt ttatctgcgt ccattcacgg cgctttcttc gcgattgcca 740821 tggtattcgc aagtgaaatg gttccgccgg aaaagcgtgc tgcagctgct gcttcaatga 740881 acggcggact gacagtggct ctaatgcttg gtgttccatt cggctcttat ctcggagatg 740941 tcctgaattg gagagcggtg ttttccatca ttacggcact tggtgtcatc ggatttttag 741001 gccttatggc tgccgtgccg aacagaaaac caaaagtgat cccaatgctt atgaatgagt 741061 ggggtgtttt taaacacaaa caagtgctgt tttccttcgc gattaccatt ttaggctatt 741121 ccggtgtctt tatcgcctac acctttatcg aacccatttt gaggcattca gccggattca 741181 gcacggttgg cattacaggt gctctctttg cgtatggatt gggaggcgtt gccgggaatt 741241 tctttgctgg aaaggtaccg ctgcctttgc tgactcggac gatgatcggc gtaatgatcg 741301 gtttaatcgg tgttctggct gtatttcctt acatcgccat ttacccggct gcagccattg 741361 tggcaacgtt cctattcggg gcatgcgcat tcggcacgcc gcctcttctg caaacaaagg 741421 tcatttcctc atctgagggc ggcacaacca ttgccgcagc tgtcagcgta tcagcattta 741481 accttgccaa tgcccttggt gcatggatcg gcggaatgat tttaaacgga acaggctctt 741541 attcctggct gtttgcagga ggtgcgctta tgaccgcatg cggacttgtg ctttctacct 741601 tcgcacactt atcagaaaag aagagcgtct acgaatatca agtcaataaa gggtaaaaaa 741661 cagctgcagt gtatgcagct gttcttcttt accgtttgcc tgaggctctc attctttctt 741721 gaggatgctg attgatagat ccgtcagcac gctttgaagc atagtcgtcc tttgctctcg 741781 gttcaccctg aaatttgttt tcgttttcgt aaggaaatcc tttttcttta tttcggacca 741841 tgtcatatcc ccctaggttc gagatcaaaa agttgcgtct tttcagatga agacgtaagg 741901 ttagtatatg gagaacacca cgtaataaag cgttattttt ttcctgaaga aaggagactg 741961 cacacatgaa tatgtacatt gagaaactga ctaatctgct tctggaaaag aacgagatga 742021 tcagctatat acaggcaaaa acgtgggtgg aattgttatg gagcgatttc gaagcaacct 742081 acgcaaaagc cggacacgcc tatcaaggtg aaaaaatgac tgaaaaaatc gtcacacaat 742141 ggattgaaaa ctatggcggc cagctccacc tttttcaaag ctcccgtaac gacgtgaatg 742201 attacttaaa tcaaagcaga ggccttttgc attaaaaacc tgccgttaac gaccggcagg 742261 ttttttcatt ttcttaaaat taccttaaca ggaagaaatc ataaacaaaa catgtttcac 742321 cagcctgtca atcagggaat accacttata tcttgtcaaa atgcgaggag gagctttata 742381 tgaaaaagaa acaagtaatg ctcgctttaa cagctgccgc aggactgggt ttgacagcac 742441 ttcattccgc tcccgcagca aaagctgcgc cccttcacga catatctgtc agcatgccat 742501 catccgatac ttacatcata aaagcaggaa agctgaatgt ccggactgag ccaaatcatg 742561 aaggtgatat tctcggcact gtatcatcag aacaaaaggt aaaagtcgat aggttcgtaa 742621 atgccgattg ggctcaaatt catttcaaag gaaagaaagc atatatttca actcactttt 742681 taatgaaaac cgcaagccaa gcgaaaacaa cgaaacagac agccttctat acaccgacgc 742741 ccgaaaacgg aaaagctaag cagctctcat ctggaacaga ggtgacaata cttgggtggg 742801 gattcagtga aaacggcgga tttgacttca cttgggcgtt cgtggattat ggcggagtta 742861 aaggctatat tcacacaaag gatttacaaa tgcgataaaa aggcaggccg aggcttgtct 742921 ttttgcctat gcatgaaaca tttcttcttt ctgcacgtaa caatgagaaa ggagatgatg 742981 atatgacggg tttagtcggc ggagggctta tgatcattgc gggcatactg atcaaactgt 743041 ttcctcccaa atcgatcaac agtgtgtacg gatacagaac gagacgctca atgtcagatc 743101 aaagattatg gaatgaagcg aaccgttaca gtgcatcatt aatgatcctg tcaggcttgg 743161 tgattgcggg aatgggtttg ctgctgggat caaacttgtt tattcttcag cttatcctgc 743221 tgattgccgc ctgtgtcata acatttatgc taacggagaa aaggctgaaa atcatgacgc 743281 acagtcaagg aggagataga agtggacgga gttaaatgcc agtttgtcaa tacgaacgga 743341 atcacgcttc acgttgcagc cgcaggacgg gaagatggcc cgttaattgt cctgctccat 743401 ggatttcctg agttttggta cggctggaaa aatcaaatca aaccgcttgt tgatgcgggt 743461 taccgggtca ttgctcctga tcagcggggc tacaatctca gtgacaaacc ggaaggaatt 743521 gattcgtatc ggattgatac attaagagat gatatcatcg ggcttattac gcaattcact 743581 gatgaaaaag caattgtcat cggtcatgac tggggaggag ctgtcgcatg gcatttggct 743641 tccacacgcc cggaatatct tgaaaaactg atcgcgatca atatcccgca cccgcacgtc 743701 atgaaaaccg taacgccgct ttatccgccg caatggctga aaagctcgta tatcgcatac 743761 ttccagctgc ccgatatacc ggaggcatca ctaagggaaa atgattatga tacattagac 743821 aaagcgattg gattatccga ccgtcccgcg ctttttacat ccgaggatgt cagcaggtac 743881 aaagaagcgt ggaagcagcc gggcgcgctg acagctatgc tgaactggta cagagccctc 743941 agaaaaggaa gcttggcaga gaaaccctct tacgaaacag taccttaccg aatgatctgg 744001 ggaatggaag accgcttttt gagcagaaag cttgcgaaag agacggaaag gcattgcccg 744061 aatggacatc tcatctttgt tgatgaagct tcccattgga ttaaccacga aaagccagcc 744121 atcgtcaatc agctgatttt ggaatatctt aagaaccaat aagctaaaat ttctctccat 744181 ccgtctgtca taatggcaga ctttttctgt gcgttttttt tcatagtctg ttttaaacat 744241 gacaaaataa cattaaaaat catgaatgtc accataaaat tgtaacaaaa aacaggttta 744301 aacgacttta aaaaaaggaa tagccttact gaagatttgt gtaaaactcc cctaaggcaa 744361 tacttaaaaa gaataataaa aagaaggtgc cttaatgaag caaggattaa tctcgattat 744421 tatcccgtct tacaatgaag ggtataatgt taaactcatt catgaatctt taaaaaagga 744481 atttaaaaac attcattatg actatgaaat attcttcata aacgacggaa gtgttgatga 744541 cacgcttcag cagatcaaag acttggcagc gacgtgcagc cgggtaaaat atatatcttt 744601 ttctcgaaac tttggaaaag aagccgcaat tttggcgggc tttgagcatg ttcagggcga 744661 ggcggttatt gtcatggatg ccgatctgca gcatccgaca tatttgctga aggaatttat 744721 caaaggctac gaagaagggt atgaccaagt cattgcccaa aggaacagaa aaggggacag 744781 ctttgtccgc tcactcttat catctatgta ttacaagttc attaataaag cggtggaagt 744841 cgatttgcgt gacggtgtcg gtgacttcag attgttaagc cgccaagctg tgaatgcact 744901 tttgaagctg agcgaaggaa accgcttctc aaaaggcctt ttttgctgga ttggctttga 744961 tcagaaaatt gtattttatg aaaatgtcga acgaaaaaac ggcacctcca aatggtcgtt 745021 cagcagtctg tttaactacg gaatggacgg cgtcgtttca tttaatcata agccgctgag 745081 attatgtttt tatacaggca ttttcatcct gctgctttcc atcatttata tcattgccac 745141 attcgttaaa attctgacta acggtatttc tgtgcctggg tatttcacca ttatctcagc 745201 agtgttattt ctcggcggag tacagctgtt aagtcttgga ataataggtg aatatatcgg 745261 ccgaatctat tatgaaacaa aaaaacgccc gcattatttg atcaaagagg cgaatatccc 745321 gaacaaagac ctgcctgaaa cgaacgaatt aaaaagcatg cggcgtctga caaaaatgca 745381 ctgaaaatac caagcgccat tggcagtgct ttttttgcgt gtctattatc ttaaaagcaa 745441 gactggagaa ttcatatgaa aagaaaacat atcatgatct atgcggccag tttgctggtg 745501 tccgttctgg cacacgcttt ttttgtgaaa gaatgggcgg aaggcaggta tatgacaggt 745561 ccgggtgacg ggcttgcgca aatgatcgta tttaaaaaat tattatttga ccaatataca 745621 cacgggaatt ttttctacaa ttattcattc ggacttggcg gcggcacatt cagtcagctc 745681 ggctattatt tttctgcgtc ttttcttttt cttgctgtgt ctgccgctgt ttggctgctt 745741 caagccgtcc agctgatcgg agaaacggat acgctttttt gggcagagtc agctgttttt 745801 atcagtattt tcaaattgag cttgatcatc tttacgtccg cttctgtttt tcattatctt 745861 cttaagcaca gggcggcatc gttcacggga gccgtgttat acggcgtctc aattatttat 745921 ttccgtcacg aagcgtattg ggaatttttc accgatacaa tggtttggct tccgctgctt 745981 gtgcttggcg cagaaaaaat tattagagag cggcgtccgg cgtggtttat cgttgcgtgt 746041 tcgctgacgt taatcaacaa tttttacttt gcatacataa accttatatt catcggaatc 746101 tatgtgctgt tcagatggct gatccgtttg gaaccacatg aagagaaaag atggattcaa 746161 atcagattat ttctcgtttc aggcttcatt tcttttggca tcagtgcggc ggcgtttgtg 746221 ccggtagtat acggtttttt aaacaacctg cgccctccat acagccagaa aatagagtgg 746281 ctcaatttcg atgataatat cttattttcg agccggatca tcattgtgcc ggccgctttt 746341 ctgctgtttt tgtttattat ttctttttac aaaaaccgtg tgtttcgtct ctttgccggg 746401 ttgagcctgc tgtttattct gtttcatttc agtccgtatg cggcaagcgt ctttaacggt 746461 ttttccgccc cgcaaaaccg gtttgaatat gttctggcct ttaccattgc gggagcagct 746521 gcggctggtt tgtcacagct gtctgaattg aaacggaaag aactgctccc ggccgcagct 746581 gtcgtcctgc ttctttactt gtatcatatc caaaggtata agctcgatat atggaagcct 746641 gcgaatgaaa gtattctatt gctcttactc atgacaatcg cagccttgtt tgctgcagct 746701 tttgcgaaaa aacgggcaaa aatggctgtg tacggtataa tcattctttc ttcgctgttt 746761 gtcgccaact cctatcaaaa atacgcgctc tcagaaggcg gcgatttgga cagtgtgaca 746821 aaagaatatc ttacaagtga ggaatacaga gggcgggaat catctgagct catcagacgt 746881 ttacagaagg aagacgatga cccgctcatg agaatcgact ggatgaacgg ggtccgcaat 746941 aatacgccaa tcatttacgg atttaatggc ttcagcgcgt attccagcat tttaaacaaa 747001 gatctgctgg ccttctattg gaatgattta agcatcgata tgggcaggga aagcgtcagc 747061 cgttacgcgt cattgggaga cagggcgaat ttatacagcc tgctttacgg caaatattat 747121 atgaccgaaa aaacaaacga agccagcgtc ccgtacggct tcaaaaagca tttagaaaca 747181 gagcattatg cagtttatga gaatcagtac atgcttccat tcgttaaaac agcggatgcc 747241 atatacagcg aaagtgagct ggaccgattg cccgctcttg cgaaagaaca ggcgatgctg 747301 aaaggaatta tattaaaaga tccatcagga aaaacggagc agacaccaaa accgtccaat 747361 ttgatcacca agtcggacat caccgcaaaa caagcccagt atcaaaacgg gctgctaacc 747421 gtaactggag aaaacggagg agagctgatc atcaccccga aacagccatc atccgctccg 747481 ggagactact atgtcagctt ttatttgaaa agcaaagcaa aagacaaagg atttacatta 747541 aaggtaaatg attatgtcac aacaaggaaa tcgaacaaat cgatctataa aaccggagta 747601 aataatataa cggtaagagt gcctaaatca ggccatatct caatcaatct tccgaaagga 747661 acctatgagc tgagaaacat agcgctctat gaagaaaatt accaaacgct gaaaaacgct 747721 gtaatgcaaa ataaaacaga gaaagcagac aaactgaatt ggaacaaaaa tcgactgacc 747781 ttttcctatc atctgtcaaa agaccagtac atcatgcttc cgatcccata tgaaaaaggc 747841 tgggagctga agatcaacgg aaaaacacag aagatcgaaa aagcggatta tgcttttata 747901 ggcttcaagg cgcaaaaggg agacaatcac attgagctga cttactatcc gccatacttc 747961 aaaatatcgg cgatcatatc tctcgtcagt ctgctgcttg ctgtttttta tataagacgt 748021 aaaaagcccg gctctatata gagccgagct ttaatttttt ctgaagtttt tcttcgctga 748081 atatccatcc cgtataggat gaacgaatcg tgagatcatg gccgatatga acaattgcga 748141 caaacggata atggcctttg ctccgataac gcaggtcgat aaatctcacc tcataatgat 748201 ctttaaacgt atccacttcc caccggtata ccggagaaaa ggacagaaac gccgcgatgt 748261 tatcatcctg ctttgccgca tgcattacat cggtttcagg aacaggcacc cgattaaatg 748321 tatccagaat cacgacatgt ccttccatgc ttcttcctac atagaaagca tgtgctgtcg 748381 tcactgcgat tcgccattgc ctgaatttca tcgttggaga aataataatg ctttcgatct 748441 catcatgaat catctcatga agcttccgtt taattctcag ctgcatgatc aggcgcacca 748501 agtagtagcc taccaatatg atatataagc tgagaaacgt gatgccggga ctcccgcctg 748561 cataccaaat cgcgatagct gccagatggc tgataaaaat aaacggatca aacgtattaa 748621 tcagcccgag cgcaacccat tttttcgaaa acggacgaat ggcttgtgtt ccataggcgt 748681 tgaatatatc aacaaagaca tgcagaacga ctgccagcag tgtccacagc cacaggtgca 748741 gaaaatcggc ctgaggataa aataaataca gaatcgccgg gatgatgaca gaccaaaaca 748801 aaacggcggg aattgaatgg gtaaatcctc tgtgattcct tatataaaca gcattgtttt 748861 taagctttaa cacagtatca atatccggag cctgagagcc cgcaagcgtt gcgatcataa 748921 cagcgtgagc cattgccgga tctgatccga caacaggatc aagcgtcgca ataccgccca 748981 gtgcgatgcc cataacgaca tgtgtgcccg tatccatagg tgacctcctt gcagggtgat 749041 cctgcacatt cactttgtaa gaaattcccc attttcatat acccaatttt taaactgatt 749101 caatcgttct catatgtttc cgctttttct ttattactat ttaatgtaac atattatcgt 749161 actgtgccct tagtgtacaa caaaaaacag tctaaagaaa agcggggcgc gaaagactgg 749221 ggagaaacac atatgaacgt acttgaagac aaattaaaac aaaaagacat acagcaattt 749281 cgcgatgatt taatctcatg gtttgaacga gagcagcgcg ttttgccgtg gagagaggac 749341 caagatccat ataaggtgtg ggtatctgaa gtgatgctgc agcaaacgag agtagagaca 749401 gtgattcctt actttctccg gtttgtagaa caattcccga cagtggaagc gctcgctgat 749461 gctgatgaag aaaaggtgct gaaagcatgg gaagggctcg gctattattc gcgagtcaga 749521 aacctgcaaa gcgcggtaaa agaagtgaaa caggaatacg gcggcattgt tcctccagac 749581 gagaaagatt ttggcgggtt aaaaggcgtc ggcccttata caaagggagc ggtgctcagc 749641 attgcctaca ataaacccat tcccgcggtt gacggaaatg tgatgcgtgt catgtccagg 749701 attctatcta tttgggatga tattgccaaa ccaaaaacaa gaacgatctt tgaagacgcc 749761 atacgagctt ttatttccaa agaaaaacca tctgaattta atcagggctt gatggagctt 749821 ggagccttga tctgtacgcc aaaatcaccc tcatgcctgc tttgcccggt tcagcagcat 749881 tgctcagcat ttgaagaagg cactgaacgg gagcttccgg taaaaagcaa aaagaaaaag 749941 cccgggatca aaaccatggc cgcgatcgta ctgactgatg aagacggaca agtgtatatc 750001 cacaaacggc cgtctaaagg tttgctcgcc aacctgtggg aattcccgaa tcttgaaaca 750061 caaaaaggga tcaaaactga gcgtgaacag ctcattgctt tcttagaaaa cgaatatggc 750121 atacaagctg atatcagtga tctgcaaggt gtagtcgagc atgttttcac ccacctggta 750181 tggaatattt cagtgttttt cggtaaagta aaacaagtgt cggataccag caagctgaaa 750241 aaagtaacga aagaagagct cgaacaattt gcgttcccgg tgtcacatca aaaaatctgg 750301 aagatggcag gagaagcagc cgccatctcg gctgctccgt aaaccattct taatcgtaag 750361 agacgcgcgt gccgtggctg tagtccgctt cattgcgctt cattccgccg cgcgcttcaa 750421 tttcttgcgt taattcccgg tattttgatt ggccttcttc gttcaaataa ggcataattt 750481 gctgaaaggc atgatgaaaa taagcgagtt cactgttctt ccaatctttt ttggaaacca 750541 tgttcaattc gctcatatca cgtccgacat acataacaga agaccccctt taaagttctt 750601 gccattattg tttgtggaaa taaaagaact atacgctaca aggagatgag gaaaaatgga 750661 acaaaataaa tgtgcactcg taacaggaag cagccgcggt gtcggaaaag cggccgcgat 750721 cagacttgct gagaacggct ataacatcgt cattaactat gcacgcagca aaaaagcagc 750781 attagaaaca gcggaagaaa tcgaaaagct tggcgttaaa gtgcttgtcg taaaagcaaa 750841 cgtaggacag cctgcaaaaa tcaaagaaat gtttcagcaa attgatgaaa cgttcggcag 750901 acttgatgtt tttgtcaata atgccgcttc aggagtacta agacctgtca tggaattaga 750961 agaaacacac tgggactgga cgatgaacat taatgcgaaa gcattgcttt tctgcgctca 751021 ggaagctgcc aagctaatgg agaagaacgg tggcgggcat attgtcagca ttagttcatt 751081 aggctctatc cgctatcttg aaaactacac cacggtcggt gtatcaaaag cagcgttaga 751141 ggctttaacc cgttatcttg ccgttgagct ttcaccaaaa caaattatcg tcaatgctgt 751201 ttcaggcgga gcgatcgaca cagatgcgct gaagcacttc ccgaatagag aagatctgct 751261 tgaggatgcg cgccaaaata cgccggcggg acgcatggtc gaaattaaag acatggttga 751321 tactgtggag tttctagtgt cttccaaggc tgacatgatc cgcggacaga caattatcgt 751381 tgacggcgga cgctcactgc tcgtttaaaa atttttaaaa aagaggaata gctatacgat 751441 cacctgcaca ttctaatgac cgtggaggtg ataacaatgg ctaactcaaa taacttcagc 751501 aaaacaaacg ctcaacaagt tagaaaacaa aaccaacaat cagctgctgg tcaaggtcaa 751561 tttggcactg aatttgctag cgaaacaaac gctcagcaag tcagaaaaca aaaccagcaa 751621 tcagctggac aacaaggtca attcggcact gaattcgcta gtgaaactga cgcacagcag 751681 gtaagacagc aaaaccaatc tgctgaacaa aacaaacaac aaaacagcta atcactgaaa 751741 cagaaaaaag cacttcatct tcgggtggaa gtgctttttt ctgtttgaaa aacgacaaaa 751801 cttgtggaag gtctacagaa tgagtcaaag ggtttgcttt atggagatcg aaatgattaa 751861 aggaggaaat gtttatactt tcatcaggct gaaggaggaa ccgatgaccg aatttgaaaa 751921 gctggtaagt gaacagatga aaacgatgga taagcttctc gatctccaat cagagctcga 751981 ccgctgcaaa caaattgagg cggaactccg gcatttggaa agggatgcaa ggctgcgtgg 752041 gattcaggct gaaattgcgg taaaacggaa acaccttgcc gatatacagg atatgtttca 752101 aaagcagaca gagcaggtca ttcgttcata tcgcagctca gaaaagccgt cttcctttgt 752161 gtagtgcagg aatgtgccat tccccggccg gaatggctct tttattttca tttttcaatt 752221 tgtaacgtta taataggtaa aagacgttgt cggtaagcaa atttggacat actaactgta 752281 gggctttata gaaagtaggg gagaaatatg ggctatccca aggaaggaga aaccattcaa 752341 attcacagct ataagcacaa cgggctgatt catagaattt ggaatgagac aacaatctta 752401 aaaagtacag aaatgtgtgt catcggagcc aatgaccgga cgatggtaac cgaatcagac 752461 ggccggacat ggataaccag agagcccgca atctgttatt ttcacgcaag acaatggttt 752521 aatgtcatcg ggatgctgag ggaagacggg gttcattatt attgcaacat cagttctccg 752581 tttgcctatg atggcgaagc aattaaatat attgattatg acttagatgt taaggttttt 752641 cctgacatga cctacaatat tctcgatgaa gacgaatatg atgatcatcg gaaagccatg 752701 aattatccaa aagaaatcga cagtatttta agagactact taaatacgct gctccattgg 752761 attcaccagc gtcagggacc gtttgcgccc gagtttgtcg atatgtggta tgaacggtat 752821 ttgcgctata caaaataatg gttacgtaaa aacctgttgc ggggtacaac aggtttttca 752881 catgggctca cacacatcat gataaagaga gagggggaat caaccgtggg ggttatgaaa 752941 cgctacatgc aattcgtcaa accttataag aagcaaattt tcgttacagt gttaatcggg 753001 atcgtaaaat tctccattcc gcttgctctc ccattgcttc tgaagtacgt agttgacgac 753061 attattcaag gaggcggcac ggccagtgac aaaaccacgt cattgttcac gattatggcg 753121 atcatgttcg ccttattttt aattttgcgc ccgcctgttg aatattaccg gcaatatttt 753181 gcccagtgga ctgccagcaa ggtgctttat gatataagag ctaagctgtt tgaccatata 753241 caaaaactga gccttcgttt ttacgcgaat acaagaacag gggaagtcat ttcccgagtg 753301 attaatgatg tagaacaaac aaaggatttc gtcatcacag ggctgatgaa tatatggctc 753361 gatatgctga cgattttgat tgtaatctct atcatgctca cactggacgt taaattaacg 753421 ctgatctcta tcgttttatt cccattatac ggaatatcag tgaagtattt ttacggccgt 753481 ttacgaaagc tgacaaggga gcgctcacag gctcttgctc aagtgcaggg gcatttgcat 753541 gaacgcattc aaggcatgcc tgtcatcaga agctttgcga tagaagatca tgaacaggct 753601 caatttaatg agaaaaacgg tcatttctta gataaagcca tccgccacac gaattggaac 753661 gcgaaaacct ttgcggtcgt taataccatt acagatttgg cgccgctcat cgtcatagcg 753721 tgcgccgggt attttgtcat taatggaccg ctgacagtcg gaacaatggt cgcgtttgtc 753781 ggatatattg acagaatgta caaccctgtt agaaggctga tcaattcctc tacaactttg 753841 acacagtcaa tcgcatcaat ggacagggtg tttgaattta ttgacgagcc ctatgaactc 753901 actgacaaac caaatgcgat aaaggccgat cagattcgcg gaggagtgga gtttcaaaac 753961 gtttcgtttc aatatgagaa ggacaaagaa aatattcttc atgatgtatc cttaaaagta 754021 aatagaggag aaactgtagc tctcgtcggc atgagcggag gaggaaaatc aacgctcgtc 754081 agcctgatcc caagatttta tgatgtaaca agcggcagac tgctgattga tgggacggat 754141 attcgcgatt atgaagcaag aagccttcgc aaccaggttg gtatggtgct tcaagatacc 754201 tttttattta gtgaaacgat tcgggaaaat atcgcgatcg gcaagcctga tgccacactt 754261 gaagagataa tcgaagccgc caaagctgca aatgcccatg aatttatcat gagttttcca 754321 gaaggatatg agacccgggt gggggaacga ggcgttaagc tttcaggcgg acaaaagcag 754381 cggatctcaa ttgcgcgggt attcctgaaa aatccgccgc tcctcatttt agatgaagct 754441 acatcagctc tggatttgga aagtgagcat tacattcaag aagcgatgga caaactggcg 754501 aaggatagaa caacttttgt tgtcgcccac cgtttatcga caatcaccca tgcggataag 754561 attgttgtca tggaaaacgg gacaatcatt gaaatcggaa cccatgatga actcatggac 754621 tatgagagcc aatacaagca cttatttacc attcaaaatt tgaactaaaa catcaatctt 754681 atatcctttt aacgaaggat ataagatttt tttgtatata aaaaaacccg gctgtttaac 754741 cgggttactc ttctgtttct atttcgcagt ctttcggatg atacgtttga aaacttgtga 754801 taagtgtttc taaatgttca agctgctcgc gatattccac ggcgcttgcc ataatattga 754861 gcatgttgta atcaataagc tcctcatccg tattctgctg attttttaaa aatgactttg 754921 ttaaaagctg cttataccgg atgccttctt caaccgcgtc atcatgcggc ttgatttttc 754981 cgacaaacct catcaaaatc cgctcgtgcc agtaaagcag gtaatcaagt tcttcagtca 755041 atgtttcctg aaactcttcc ggcatatgat agatctcgtt ttccagacga tgcagcttct 755101 tcaatgtatc aagcgcccga tttgcagtaa taatggcctg tctgaacagg acaagctttc 755161 ttgatttcac ataagtcgtt ttcttaaagt aacttctttc ttctttatat agaagatatg 755221 tctgatcaag cttgatcatt ttttctttca gtttttcaat atcctctttc aaaatcgaat 755281 gctctgtcga ctgccgcatg gacaatctga tccacttcat aatttcttcg gtgttttcga 755341 cggtattatg aatcagcttt gtttcgtact taggaggcaa aaacacaagg ttgacgataa 755401 aggaagaaag cacccctaag atgactgtgc ttgttctgat cagcgcgaac attaaaaagt 755461 cgtcaccggc agattctaat atcgcaatga ctgttacaag agcaattgaa attgtatgtt 755521 caattttaag tttcagcatg attgtaatga caataactgc tgttaacccg atcataatcg 755581 ggctgggtcc gaaaataagg ccgaacactg tggcaatcac agctccgatg atatttgctt 755641 gaacctggtc aataataatg agaaaagagc ggtaaatcga cggctggatc gcaaatatcg 755701 ctgcaattcc agcgaaaatc ggcgcgggaa gcccgatcca cgaagccaaa taaagggcaa 755761 gtgtaatcgc aatcccggtt ttgaaaatgc gggcaccaag tttcattggt ttgtgcgtgc 755821 attcctttct atagtaaatt gtgtgacata gcaaatgggc taatccttaa aattcccggt 755881 tagtttattt gctaaacaat taagtaatat acagggatcg atacaaatat tcaagctatt 755941 tttctagaaa aagaccaaaa tcttacacgc tgtttgattc cataaaaaaa caggagctca 756001 aagctcctgt tcaaggtatt tgattctagt tttttagatg tttaaatgca tcctcgaccg 756061 ctgtaagcgt gtctttaata tcctgctctg tatgtgctgt ggtaataaac caagcttcat 756121 acttagaagg tgctaaatta attccgcgtt ccagcatcag cttgaaaaac gtagagaatg 756181 tttctccgtc actccgttca gcctgctcgt aattttccac tttctcatca gagaagtata 756241 ccgtgagcgc accttttaac cggttgaccg taatggtgat gccgtgtgtt tctgcgtgct 756301 tcaaaatgcc ttcctcaagc atagcgccaa ggtgatcaag cttttcatac acgccttttt 756361 ctttgagcac ttccagacaa gcgatgcctg ataggatgga agcggggttc cctgccattg 756421 ttcctgcctg ataagcaggc cctagcggag ctacctgctc catgatttct tgtttgccgc 756481 cataggcccc aatcggaagt ccgccgccga taattttccc gagtgctgtt aaatctggtt 756541 tcacctgtaa gagatcctgc gcgccgccat acataaagcg gaaagccgta atgacttcat 756601 cgtaaataac gagagcccct gcattatgtg ttaattcatt tacttgttct aagaagccct 756661 ctttcggctc cacgataccg aagttgccga caatcggttc aacgagaacc gccgcgattt 756721 cactgcccca tttttcaaga gctgctttat agctatcgat atcattaaat ggtactgtga 756781 tcacttcgtt tgcaatgctt ttcggtacac cggctgagtc tggtgtgccg agagtagacg 756841 ggccggagcc tgcggcgaca agcacaaggt ccgaatgccc gtgatagcag cccgcaaatt 756901 taatgatttt tgtccggcct gtatatgcgc gagccacgcg gatggtcgtc ataacggctt 756961 ctgtacccga attgacgaat cttactttgt ccatagcggg aatggcttct ttgagcattt 757021 ttgcaaatgt aacctcgtgt ttcgttggtg ttccatacaa tacaccgttc tctgctgctt 757081 ttttaatcgc ttctgtaata tgcggatggg catgtcctgt aataatcgga ccgtacgccg 757141 ctaaataatc gatgtatttg ttgccgtcca catcccaaaa ataagcgccg cttgctttct 757201 ccattgcaac aggagaaccg ccgccgactg ctttatatga tctagacggg ctgtttacac 757261 cgccgacaat gtgctgtaat gcctcattgt gaagttcaat tgattttgta tgcaagaata 757321 aaaacctcct atatctccat gcgtcctttc tattgtagca tgcttccgaa caagaacaat 757381 ggcttcgggc ttcagattca gctgagatgg ttgtaatctg gacaagaatt ggatacgctt 757441 aataaaaaaa catccggagg taacgtaatg actatagaaa tcggacaaaa agcgcctgat 757501 cttgagttaa aaggtgatca tggggaaaca gtaaaattat cggattataa aggaaagtac 757561 atcgtgcttt atttttatcc aaaggacatg acaccgggat gtacaactga agcatgcgat 757621 tttcgggaca gtcacgaaag cttcgccgaa ctggatgccg tcattatcgg cgtcagcccg 757681 gacagccagg aaaaacacgg aaaatttaaa gagaagcata accttccatt tctgcttctt 757741 gttgatgacg agcataagct ggcggaagca tttgatgtgt ggaagctgaa gaaaaacttc 757801 ggaaaagagt atatgggaat cgagcgttcc acttttttaa ttgataaaga aggccggctc 757861 attaaagaat ggagaaaagt aaaagtaaag gaccatgtag ccgaagcgct tcaaaccctc 757921 aaagatatgt ctgaaaagta aatctctatg agcctatgct tacttttacc ctgatatcaa 757981 ttgacaaatt atcgtagaaa gagttacact aattataaac attacaatgt aagaattttt 758041 tttagaagag aggtgcatga cggatggctg cacatgaact aaaagaagcc ttagaaacgt 758101 tgaaggaaac cggagttcgc attactcctc aacgtcatgc gattctggaa tatctcgtta 758161 actctatggc tcatccaaca gcggacgata tatataaagc tctggaaggg aaatttccta 758221 acatgagcgt agcgacggta tataacaatt tgcgtgtgtt ccgggaatca ggtttggtaa 758281 aagagctcac atacggtgat gcttccagca gattcgattt tgtcacatcc gatcactatc 758341 acgcgatttg cgaaaactgc ggtaaaattg tggacttcca ctacccgggc cttgatgaag 758401 tggagcagct cgctgcccac gtcacgggct tcaaggtaag ccaccaccgt ttagaaattt 758461 acggcgtctg ccaagagtgt tcgaaaaaag aaaatcatta aaaataagct gaccgcacga 758521 aacggtcagc ttattttatt tcgacatttt ctttttatta taagactcat caaattcttt 758581 tccttctaat cccttatcta aagtcagcgg ctctcggcaa tgcatgcaca tatcgactac 758641 tcctaaaacc tttgtctctt tatcacagcc tggacaaatg acgcgaaccg ctttagtcga 758701 aagcattccg atccaaaagt aaactaccgt gctgagaccg atggataaaa gcccaagtat 758761 cataaacaaa ctagaaagca aaactgactc tttgaaaaag atcccgatgt acataatgat 758821 aaacccaacg aaaaccaaac ttaacgcaaa tgttctgatt ttattaattt tgctggagta 758881 tttcgccatg tccatccccc tctgttttaa ctatagcaca aacccgatgg gattttcttc 758941 atgttttcgg ttgaactgga atttacatat ggagagttac tgtgaaattg tttataatag 759001 ttcaatgtgt ttagaaaaaa ggaatttcgt tttaaccata gaattgaatc aaatagagaa 759061 taaaaaaatt tgaacaattg cattggagga atagtgatgg aaaatcttct ccgtccaatt 759121 taccaagaaa gagcaagtca ccccaataca ttggctgtca ttatgattga gagaagaaac 759181 aaaacatctt ccttaacaga taactttgat gcagctttgc tggtgattgt aaaggatgct 759241 gatgagccag tttttataaa gcattatgaa tttgatcatc aaacagcttc tttgcatgtg 759301 gtaacagatt ctcagattca agaatggatt ttgcttggaa caaatagaag aatcatagat 759361 tggattgtaa atggcagagt cttgtttgac cgtaatgaat acgtagttga actgattgac 759421 aggctgaata catttccgtt tgccgaacgt aaactgaaga tcggactcga atacggcaaa 759481 ttaatcagaa ggtatgttga agggaaagct ttttttgaag ccaatcaatt tttagatgcc 759541 tacaatgccg ttgttcatgc gctgcatcat ttagcacgta ttgaagtaat cgacagagga 759601 ttccatcccg aaaccacggt gtggagccaa gtgcgccaga tggagcccca agtgtacaaa 759661 ttatattccg agctgattga aagtcatgag agcctggaaa aaagacttga attattattc 759721 ttagcaaatg attttctcat ccattccaaa gccgagatcg gttcggcgca tcttttcgaa 759781 gtaatgaaag aaaaagacat ttggcaattc ggtgagcttc ttcaacatca tgacctaaag 759841 cactttaccc aagatcttgg cgttatgctt gattacttga cggaaaaggg acttatcaac 759901 gtctgccaga tagaaacgaa aggacaggct gtctatcacc gaggatattc ttttaaaaaa 759961 ggtgttgact ctgattcttg accgtgttat attattaaac gtcgctgatg cgcttctgag 760021 aaaacaagct cacagcggcg ggaaaataaa tcaaaaaaac atttgacaaa agaaagtcaa 760081 aatgttatat taataaagtc gcttcaacaa gaagtgaaaa tgatctttga aaactaaaca 760141 agacaaaacg tacctgttaa ttcagttttt aaaaaatcgc acagcgatgt gcgtagtcag 760201 tcaaactagg gcctgcacga cgcaggtcac acaggtgtcg ccgcaggatg cggtgaactt 760261 aacctgtgat ccatttatcg gagagtttga tcctggctca ggacgaacgc tggcggcgtg 760321 cctaatacat gcaagtcgag cggacagatg ggagcttgct ccctgatgtt agcggcggac 760381 gggtgagtaa cacgtgggta acctgcctgt aagactggga taactccggg aaaccggggc 760441 taataccgga tggttgtttg aaccgcatgg ttcaaacata aaaggtggct tcggctacca 760501 cttacagatg gacccgcggc gcattagcta gttggtgagg taacggctca ccaaggcaac 760561 gatgcgtagc cgacctgaga gggtgatcgg ccacactggg actgagacac ggcccagact 760621 cctacgggag gcagcagtag ggaatcttcc gcaatggacg aaagtctgac ggagcaacgc 760681 cgcgtgagtg atgaaggttt tcggatcgta aagctctgtt gttagggaag aacaagtacc 760741 gttcgaatag ggcggtacct tgacggtacc taaccagaaa gccacggcta actacgtgcc 760801 agcagccgcg gtaatacgta ggtggcaagc gttgtccgga attattgggc gtaaagggct 760861 cgcaggcggt ttcttaagtc tgatgtgaaa gcccccggct caaccgggga gggtcattgg 760921 aaactgggga acttgagtgc agaagaggag agtggaattc cacgtgtagc ggtgaaatgc 760981 gtagagatgt ggaggaacac cagtggcgaa ggcgactctc tggtctgtaa ctgacgctga 761041 ggagcgaaag cgtggggagc gaacaggatt agataccctg gtagtccacg ccgtaaacga 761101 tgagtgctaa gtgttagggg gtttccgccc cttagtgctg cagctaacgc attaagcact 761161 ccgcctgggg agtacggtcg caagactgaa actcaaagga attgacgggg gcccgcacaa 761221 gcggtggagc atgtggttta attcgaagca acgcgaagaa ccttaccagg tcttgacatc 761281 ctctgacaat cctagagata ggacgtcccc ttcgggggca gagtgacagg tggtgcatgg 761341 ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc gcaacgagcg caacccttga 761401 tcttagttgc cagcattcag ttgggcactc taaggtgact gccggtgaca aaccggagga 761461 aggtggggat gacgtcaaat catcatgccc cttatgacct gggctacaca cgtgctacaa 761521 tggacagaac aaagggcagc gaaaccgcga ggttaagcca atcccacaaa tctgttctca 761581 gttcggatcg cagtctgcaa ctcgactgcg tgaagctgga atcgctagta atcgcggatc 761641 agcatgccgc ggtgaatacg ttcccgggcc ttgtacacac cgcccgtcac accacgagag 761701 tttgtaacac ccgaagtcgg tgaggtaacc ttttaggagc cagccgccga aggtgggaca 761761 gatgattggg gtgaagtcgt aacaaggtag ccgtatcgga aggtgcggct ggatcacctc 761821 ctttctaagg atattatacg gaatataaga ccttgggtct tataaacaga acgttccctg 761881 tcttgtttag ttttgaagga tcattccttc gaaacgtgtt ctttgaaaac tagataacag 761941 tagacatcac attcaattag taatacaaga tatcacatag tgattctttt taacggttaa 762001 gttagaaagg gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac 762061 accgatatgc ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa 762121 cccaccactc gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac 762181 ccggggaact gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt 762241 agcggcgagc gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac 762301 actctgtacg gagttacaaa agaacgaggt agatgaagag gtctggaaag gcccgccata 762361 ggaggtaaca gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg 762421 gaacacgtga aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta 762481 gtgaccgata gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg 762541 aaagagatcc tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt 762601 gccttttgta gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg 762661 agccgcagcg aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc 762721 aggtgatcta cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca 762781 cgcacgttga aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg 762841 agatagctgg ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg 762901 tagagcactg attggactag gggcccctac cgggttaccg aattcagtca aactccgaat 762961 gccaatgact tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa 763021 acagcccaga ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt 763081 tgcttagaca accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc 763141 tcactggtcg agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg 763201 cggactgttc ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa 763261 ggactggtgg agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa 763321 tcccctccac cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg 763381 gacctaagcc gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac 763441 ctcctcacca tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata 763501 tccgcgtcca agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg 763561 tgatggcgag cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct 763621 agcgaggtga gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa 763681 ggtgatcgag agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa 763741 ggggtgctct gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt 763801 ttagcaaaaa cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc 763861 cggtgctgga aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag 763921 taaacggcgg ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc 763981 cgacccgcac gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt 764041 atagtacctg tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta 764101 ctgcagcctg atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac 764161 cggagcgcca gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct 764221 aacccgccgc ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt 764281 cgcctcctaa aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc 764341 gcagagtgta aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa 764401 agtcgggctt agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc 764461 taccccgggg ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca 764521 cctcgatgtc ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg 764581 cccattaaag cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc 764641 gtcgcgggcg caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg 764701 caccgctggt gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg 764761 ataagtgctg aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca 764821 aggaagtaag atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac 764881 acatggagct gacagatact aatcgatcga gggcttaacc atatttttga atgatgtcac 764941 acctgttatc tagttttgag agaataagtt tttcaaaaaa acacttgatt ttctcaagaa 765001 tacatagtat aatgttaaat gtcactgaaa ttgtctggtg atgatggcga agaggtcaca 765061 cccgttccca tgccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 765121 ccccctgtga gagtaggaca tcgccaggca gacttcattc cgcagtagct cagtggtaga 765181 gctatcggct gttaaccgat cggtcgtagg ttcgaatcct acctgcggag ccattattgg 765241 agagctgtcc gagtggtcga aggagcacga ttggaaatcg tgtaggcggt caactccgtc 765301 tcaagggttc gaatcccttg ctctccgcca ctgatactta tacataatta caattgaaag 765361 tctgggcccg ttggtcaagc ggttaagaca ccgccctttc acggcggtaa cacgggttcg 765421 aatcccgtac gggtcattat atgatggagg attagctcag ctgggagagc atctgcctta 765481 caagcagagg gtcggcggtt cgagcccgtc atcctccacc attatatcat cgcggggtgg 765541 agcagttcgg tagctcgtcg ggctcataac ccgaaggtcg caggttcaaa tcctgccccc 765601 gcaaccaaat tttaaaatgg tccggtagtt cagttggtta gaatgcctgc ctgtcacgca 765661 ggaggtcgcg ggttcgagtc ccgtccggac cgccatttga atacttaggc tcggtagctc 765721 agttggtaga gcaacggact gaaaatccgt gtgtcggcgg ttcgattccg tcccgagcca 765781 ccacctatgc cggtgtagct caattggtag agcaactgac ttgtaatcag taggttgggg 765841 gttcaagtcc tcttgccggc actgtttttt caaaatttaa tgtggagggg tagcgaagtg 765901 gctaaacgcg gcggactgta aatccgctcc ctcagggttc ggcagttcga atctgccccc 765961 ctccaccatt tataggggca tagtttaacg gtagaacaga ggtctccaaa acctccggtg 766021 tgggttcgat tcctactgcc cctgccaaat ttatgacatc ttgagattat ggcggttgtg 766081 gcgaagtggt taacgcacca gattgtggct ctggcactcg tgggttcgat tcccatcaat 766141 cgccccatat tatcattggg ctatagccaa gcggtaaggc aacggacttt gactccgtca 766201 tgcgttggtt cgaatccagc tagcccagtc tcacttttta tatcaactgc atataatgta 766261 ttaagtccat taaaaatgcg gaagtagttc agtggtagaa caccaccttg ccaaggtggg 766321 ggtcgcgggt tcgaatcccg tcttccgctc caattacggc ggcatagcca agtggtaagg 766381 cagaggtctg caaaaccttt atccccggtt cgaatccggg tgtcgccttc ttattgccgg 766441 ggtggtggaa ttggcagaca cacaggactt aaaatcctgc ggtaggtgac taccgtgccg 766501 gttcaagtcc ggccctcggc accaatttta cttacatggt aagttgaatt ggtgtttgtg 766561 ttttatcatt ataactaatc atattaatga tctacataag tagatcattt ttttaatgct 766621 ttgatttatc ataacaagtt aagttccgag gcctattata aagcggctgt atagctagtc 766681 tttcaacact tttattttat atttccataa aaactttttt gaaatacgtt gacactttat 766741 gagatccatg atatatttat attcgtcggt tagatacgac gtaaaacttg ccggtgtggc 766801 ggaattggca gacgcgcacg actcaaaatc gtgttccttc tggagtgtcg gttcgacccc 766861 gaccaccggt atactgaaaa acccgtttct taacagaaac gggtttttat tttttattaa 766921 agaaaaggag cctcggctcc tttttatact tactcagcgt attggtctag gatctcttct 766981 agcacctctt ctagctcttc tgtatcttca agctctgatt ggctgaaacg gacgcgtaca 767041 agctgttctc cgtcattata catctcttcc aaccaccctc ggagtcctct tgctctgcgg 767101 tcgacttcga aaatgatttc caaaccgtct tcgtctaaaa ggaaaatgag ctctaattca 767161 tcaagcatct gacgataata tccggaagtc ggaacgaatt cgaattcttg aacgaacgga 767221 agacgacgct ggaagtaggg cgcttgttcg cagtctgctt cgttaagacg gaagcccagg 767281 ttttcgattg cttcaagcac attttcaatc caagggtgcg cttcaacgaa aatgcggtca 767341 tgatcggatt tatcgatacc gccttgaatg tcaaggtctg tcaccacggc aacctctact 767401 ttccctacag tgatcggcgt atctagaggc agagtgaatg tgaacggaaa ttgatgctct 767461 tcaccaggct gtatggtaaa tgaaccagtg acccggaaag aatgaattgt agcgtatttc 767521 cggtgctctt catcgtcttt tacaatgaca taccgtgtgc taagctgtaa atcgatataa 767581 cggatgtcct gagcgatttt tccgcctttg acatgtaccg ttccctgtac ttcttctcct 767641 ggaaaatatg cgtctttttc taaaattgta tctacttttg cagctccaat tccggcactt 767701 gccgcaagct tcttaaaaaa tgacatgtta gatcttcccc tttttctttt ttctcaacag 767761 atatacgtaa gaaggaggaa aaaagattcg tttgattcat acttttttcc tattattcgt 767821 ctcggcctag ggacagacta agaataatat tgaaaataaa ggagtcgatg gaagtgaata 767881 aagaaagttt ggttgcagat gaattacaca gaatgttttt ggctggtgag ctgcaaatca 767941 cagtagagga ggatataaac aatatttccg aaaggctgag aaacggcgat ctcagtttag 768001 accgattaag cggtgaagac gtgtttataa aagaaacggt aaatgaggct ttaagaagag 768061 tggagcaata aaaaagagac ggcatctcat ctttgagatc ccgtctcttt ttgtggtctt 768121 tgctgtaaga taaaagcgaa tcgatttgga attgctcacc cgagccaccc cttttctaac 768181 agaagatctg acagttcatc atggagataa acagctgtat ctaattgatc atgcaatgct 768241 cttctgatgt ggggattttc ggttgctgtt gttgcgacag tgtatttgtt aatgctggtt 768301 tttattgttg ttaacaaatc aagaatatct ttgggacaaa gactttgttc aatgggaaac 768361 cacctccttt gtttttttag cagctcctga taagaaagta tttgactttg tttcttgctt 768421 ctatacaaaa tgctataata agcaacaaat tttgttgggg ggtgtgatga tgaagcagat 768481 tattgcgatg gggggcgggg gtttttcgat ggagccggat aatttgtccc tcgatcaata 768541 tatcctcaat caatcaaaac gagagcagcc tcgtatttgt tttttgccga cggcgagcgg 768601 agattcccaa aactatattc agcggtttta tcatgcattt caaacattgg attgcgtgcc 768661 gtctcattta tctttgttta agccaccatc atcagattta gtttcttttg ttatggaaat 768721 ggacgtgatt tatgttggcg ggggaaatac gcggaattta cttgtgttat ggaaagagtg 768781 ggggctggac catattctca gggaagcatg gaagaacggt gtggttgtag ctggaataag 768841 tgccggtgcg atctgctggt ttgaagaagg ggtgacagat tcagccggac cgctgacaag 768901 tttgaaaagt ttaggttttt tgcaagggag cttttgtccc cattatgacg gggaaaagga 768961 tcggagaccg gcataccacc agctgatatc taacaagttc ttatgcagtg gctatgcagc 769021 ggatgatggg gctgctctcc atttcataaa tgatcagctg tttcagactg tgagttcaag 769081 gtcgggtgca aaggcatatc gggtgatgat ggctgaacat gaaatagctg aaatcccgtt 769141 gccggtcaaa tatttagggt gaaattggct gaatattatc tatattcctc tttttttcag 769201 attgatttta tgataagatg agtgcgaaat caatagttac tgggggtgcc cgctttcggg 769261 ctgagagaga aggcaagctt cttaaccctt tggacctgat ctggttcgta ccagcgtggg 769321 gaagtagagg aattgttttt gttattgtct tgctgggcaa taatatgttt ctttctgact 769381 gtaaccgggt tcatttatat gaatccggtt ttttgtgctg gttatgggct tgattttgtc 769441 ctttcaaacg tagaaagggg aaggaaaagt aatgcaaaac aattcagtgc agcaagccaa 769501 catttccatt atgtcaagtt tttcaggcag caagaaggta tacgtggagg gttcttcttc 769561 ggacatccaa gtgccgatga gggagattgc attgagtccg acgacgggat cgttcggcga 769621 agaggaaaac gcgcctgtgc gtgtctatga tacaagcgga ccgtatacgg accctgaagt 769681 aaccattaat attcaagaag gattaaagcc gctccgccaa aaatggatca cagagcgcgg 769741 tgacgtggaa gagtatgaag gtcgggctat aaaaccagaa gataacggtt ataaaaaagc 769801 aaaaccaaac gtaagctatc caggattaaa gcggaaaccg ctgagggcga aggcaggtca 769861 aaatgtcaca caaatgcact atgcaaaaaa ggggatcatt acacctgaga tggaatttat 769921 cgccattcgt gagcatgtgt ctcctgaatt cgtcagagac gaggtagcca gcggccgggc 769981 gattattcct tcaaacatta atcaccctga aagtgagcca atgattatcg gccggaattt 770041 tcatgtgaag attaatgcaa atatcgggaa ttcagcggtt acgtcatcca ttgaagaaga 770101 agtggaaaaa atgacgtggg ccatccgctg gggagcggat acgatgatgg atctctctac 770161 cggaaaagat attcatacga cgcgtgaatg gattatccgc aattgccccg tgcctgtggg 770221 aactgttccg atttatcagg cgcttgaaaa agtaaacggc gtagctgagg atttaacgtg 770281 ggagatttat cgtgatacgc taatcgagca ggcagagcag ggagtggatt attttacgat 770341 tcacgcgggt gttttgctta ggtatgtacc gctgactgcc aaacggacaa ctggtatcgt 770401 gtcacgcggg ggagcgatta tggcgcagtg gtgtctggct catcatcaag aaagcttttt 770461 atacacacat tttgaagaaa tatgtgagat tatgaaaatg tatgatattg ctttctctct 770521 tggggatggt ttgcgtcccg gatcaattgc tgatgccaat gacgaagcgc agtttgctga 770581 attagagacg cttggagagc tgacgcaaat tgcctggaag catgatgttc aggtgatgat 770641 tgagggtcct ggacatgttc cgatgcataa aatcaaagag aacgtcgata aacaaatgga 770701 catttgtaaa gaagcgcctt tttacacatt ggggccgttg acaacggata ttgctccggg 770761 atatgaccat attacttcag cgatcggagc ggcgatgatc ggttggtacg ggacagcaat 770821 gctttgttat gtaacgccga aggagcattt ggggctgcca aaccgtgatg atgttcgtga 770881 aggagtcatt acatataaga tcgctgcgca cgctgcggac cttgcaaaag ggcatcccgg 770941 agcgcaaatc cgggatgatg cgttatcgaa agcccgtttt gaattccgct ggcgggatca 771001 gtttaattta tctcttgatc cggagagagc ccttgaatac catgatgaaa ccctgcctgc 771061 tgaaggagca aaaaccgctc acttttgttc catgtgcggt ccgaaatttt gcagcatgag 771121 aatttcacag gatattcggg attatgcgaa gaaaaacgat ctcagtgaag cagaagccat 771181 aaataaagga ttaaaagaaa aagcaaaaga gtttgtcgat acgggaagca atttatatca 771241 ataaaaaaaa tgaagatgga gaatgctcca tcttcatttt tttagaaaaa cagagagcgt 771301 cgaagcggag gaatactctg ttcaaagcgg aaaacatttt ctggatcata tgtcgttttg 771361 acacggcgga gtcgttcaac gttttcgccg taatatgttc ttggccagtt tctgatttcg 771421 atatctggcc aatttacgta gtctcccatc gtttctttcg aaagggacgt tctcagcccc 771481 tcaatccagc ggacattttg tcttttttct ccaggggatg tccagtttgt taagtattcc 771541 tgggcgatga ttgcgtcacg ataataaaat gccgtttggt cgggagcgac ccgtccggct 771601 gccccgccga gtgcttgctg ccagacactg gcgttttgat tcggagcgtg ctctaaaaag 771661 tgttttattg ttgagatcgc acgttctgat aatggctttt caatgaaaga gccggagcgt 771721 ttcatttttt gaggctgatt gcctcccggg ctgttaaaaa aggttaccgc ttcaatgaat 771781 ggcgttgttt ttaccattcc gcttgtcgga cttcctgctt tcaataaagg ctttaacagt 771841 ttttttaact ctgtttttgg cccgacaaat tggccgaggg cttctatgcg gtttacttct 771901 ttaggccaaa actctattga tgatgtaagc cggtcatctg tatacggggc ccagttctgc 771961 cacgtgttat atacttcctc aaaatcatcc catccccatg taatagaaaa aatcgacact 772021 tgagagatgg gcactgcttt aaatgtcatg gaggtgacta tgccgaaatt gcctcctccg 772081 cctccctgag acgcccaaaa taagtctgga tgatttgaac agctgactgt aatcagatca 772141 gcgccctctt tttcgtctgc tacgatcatc tcaagctgca cgaggctgtc gcaagtaaga 772201 ccggcagccc ttgttaaaag tccaattccc cctccgagag ttaaacctgt gagccctaca 772261 ttagcaatgg tgcctgcggg aagcgtcagg ccgtattgcc agagtgtccg atagacttct 772321 cccaattcag cccccgcttc aatataggcc agctttttat cctgattcac agttattttt 772381 ttcatctcgc ttaaatcaat aacaagaccg ttatttaaaa gggaaaagtt ctcatagctg 772441 tgtctgccgc ctctaatacg gaaaggcaca cggttttcac gcgcccattt cagcgcattg 772501 agtgcatcct gtttgttttg gcaaaacaca atgatgtcag gatacctttc taagcttagg 772561 ttaatattgg ttcttgcttc gttatagtcc ggatcatccc gtgtcacgat acgtccggtc 772621 aattttgtct tttccacact cccacatctc tttctctcgt attctagttt ctctagctta 772681 tgcgtcaggg gaaaagagtg tataaggaaa aagcggggat gcaatctgat acagtgtcaa 772741 caccctcaaa aaatagttga caggtcggta ttgtatgaat taacatggtc agtacaaatt 772801 tttcaaattt atcgcgctga tcggaacacc gaaggctctt atcgtttaga taagggcctt 772861 ttttgtatga aaaagggggg attattgatg ggagtcaaaa aagaaaaggg gagaaaacga 772921 ttcaggaagc gaaaaaccta cgggaatcag attttgccgc ttgagctgct gattgaaaaa 772981 aacaaacgag agattataaa cagcgcggaa ctcatggaag aaatttatat gaagattgat 773041 gagaagcata cgcaatgtgt aactaaatat aaaaaaaccc gctgactaca acgggttttt 773101 gcatttctcc attaagaatc ttttttaatc ggcaatccaa ggccttctgc cacgcgtttt 773161 ccgtattcag gatccgcttt gtagaagtgc tcgatttggc gcagcttgat ttcttctttt 773221 tctaccggct tcatggcatt aacgatattt tcaacaaggc gggtacgttc atcttcactc 773281 attaaacgat acagatcgcc ggcttgagtg tagtgatcgt agtgatcgta gcttacgctg 773341 tcagcgatac cttgtaccgg atatgctgct tgcttatcct caggtgactc ttttggaccg 773401 ccgaagctgt taggctcgta atacacagat ccgccgccgt tatcatcaaa acgcatttgc 773461 ccatcacgct gataattgtt tactttgttg cgtgcgcggt tgattggcag cgcttgatgg 773521 tttgcaccga cacggtagcg gtgtgcatca tgataagcaa aaagtcgacc ttgaagcatt 773581 ttatccggtg aaacatcaat accaggcacg agggttccag gtgaaaatgt cgcttgttct 773641 acctctgcaa agtagttttc cggatttctg tctagaacca tgcgtccgac ctcgattaac 773701 gggtagtctt tttgagacca aacttttgtg acatcaaacg gatcgaaacg gtacgtattt 773761 gcatcttcta aaggcatgat ttgcacatat agtttccatg caggataatc accgttttcg 773821 attgcgttga aaaggtcttc tgtatggtaa tcagggtttt caccggcaat ttttgctgcc 773881 gtattgacat caaggttttt cacgccttgt tctgttttaa agtgatattt aatccatacg 773941 ccttcgcctt cggcatttgt ccatttgaat gtatggcttc cgaagccgtg catgtggcga 774001 agtgtcgcag gaattccgcg gtcagacatc aggattgtca cttggtgcag tgactctggt 774061 gaaagtgacc agaaatccca tacagccgta gggtttttca ggtgtgtttt tggatctctt 774121 ttttgtgtat ggatgaaatc agggaactta atcgcatcgc ggataaagaa tacaggcgta 774181 ttgttgccga cgatgtcgta gtttccttct tcagtataaa atttaacagc aaatccgcgc 774241 gggtcgcgaa ctgtgtcagc agagccaagt tcaccggcaa ctgttgagaa acggatgaac 774301 aacggtgtgc gtttgccgac ttcagaaagg aaagcggctt tcgtgtattt tgttacgtcg 774361 tttgtcactt caaaatatcc gtgtgcgcct gctcctttgg cgtgaacaac acgttcagga 774421 acacgttctc ggttgaaatg ggccaatttt tcgagtaaat gtacatcttg aattaaagtt 774481 ggtccgcgag aaccggcagt cattgagttt tgattatctc caaccggagc gccccagcta 774541 gttgtcagtt tatttgaact catgttatca cctcttggaa tttataagaa cataatatca 774601 tctctaagta aaaagtcaat attattttat aattattata aaatagttat ctctattaat 774661 cgatatatag tatcgaaatt gttgaaaaac cttgttgtaa cagcttttta tgacacttaa 774721 taatttttgg agaaataatt tttccttctc tatttgcgaa acaagcagag taagtgataa 774781 acaaggatat caaaaatcgt atttaaaaaa gagttgacat atcggaataa tttgaattaa 774841 catgttattc aaacaaaaaa acaattgggc agctgatcgg accgccgaag gctctcatct 774901 ctacaagaac agagatgggg gcctttttgt tttttttgaa ggcggggttg gcagaaagag 774961 agggataaaa gtggctgtga ccatcagcat caaagaaaag gcatttgttc aagaaggccg 775021 caaaaacacg gtcttagaaa acatagaatt atcaatcgca ccaggcgaat ttctaacgct 775081 tatcggaccg agcgggtgcg gaaaaagcac cctgttaaag attattgcag ggcttgattc 775141 tgaatatgac gggagtgtgg aaattaacgg ccgcagcgta acagctccgg gtattcagca 775201 aggatttatt tttcaggaac accgcctctt tccttggctg actgttgagc agaatattgc 775261 agccgacttg aatttgaagg acccaaaagt caaacaaaag gtggatgaac tgatcgagat 775321 tgtcagattg aaaggatcgg aaaaagcata tccgcgcgag ctgtcaggcg gcatgtcaca 775381 aagagtagcc atcgcccggg ccctgctgcg ggagcctgag gtgctgcttt tagatgaacc 775441 gtttggtgca ctcgacgctt ttacaagaaa acacctgcag gacgtgctgc tggatatatg 775501 gaggaagaaa aaaacaacga tgattctcgt gactcatgat atagatgaat ctgtttattt 775561 aggaaatgag cttgcgatcc ttaaggccaa accggggaaa atccataagc tgatgcccat 775621 tcacctggcg tatccgcgaa accggacgac tccggatttc caagcgatca gacagagagt 775681 gctgtcggaa ttcgagaaaa cagaagattt ggagtacgca gaaggatcag ggatatagaa 775741 agggcggaag cggaaatgaa aaaaggactc attgtattgg ttgccgttat ttttctgctc 775801 gcaggctgtg gagcaaatgg agccagcggt gaccacaaac aattgaagga aattcgtatt 775861 ggtattcagc aaagcttaag cccccttttg attgcaaaag aaaaaggctg gttcgaagat 775921 gcatttgaaa aagaaggcat caaagtgaaa tgggtggagt ttcaaagcgg tccgccccaa 775981 tttgaaggcc ttgcggcaga caaacttgat ttttctcaag tcggtaattc gcctgtgatc 776041 gctggacagg cggcaggcat tgactttaaa gaaatcggtt tgtctcagga cggcttgaaa 776101 gcaaacggca tccttgtcaa tcaaaacagc ggcattcaag acgttaaggg cttaaagggg 776161 aagaaaattg cagtcgccaa aggcagcagc gggtttgatt ttttgtataa agcgcttgat 776221 caagtggggt tgtcagctaa cgatgtgaca attattcagc ttcagcctga tgaagcagct 776281 tccgcatttg aaaacggatc tgttgatgcc tggtccattt gggagccgta cttgtcctta 776341 gaaacaatga aacacggagc aaaaatcctt gtgaacggag aaagcacaga tttatattca 776401 ccgggtttta ctttagtaag aacaaagttt tcagaagagc atccagacga agtggtccgt 776461 tttctgaagg tgtttaataa agccgttgta tggcaaaagg aacatctgga tgaagcagcg 776521 gacttatatt ctgacattaa agatctcgat aaaaaggtcg tcgaaaatgt gctgaaaaat 776581 actgagccac ttaatgagat catcagtgac gacattgtga aagcacagca ggaaacagca 776641 gattttcaat ttcgaacaaa ggcgatagat aagaagattg atgtgaagga tgttgtcgat 776701 aacactttta tcaaaaaagc attagaggag cattcctcag gaggtgatca atgatgaaag 776761 cagaggctgc gggctcgctg cccaaaacga atgcggaagc ggtgcgaaaa aagcccggaa 776821 ggaagagata cggctggatg aaggggcttt tactgcccgc tgtcatcatt gccatctggc 776881 aggtcatcgg cgggctgggg gttgtgtccg ctacagtgct gcctacacct gttacgattg 776941 ttctgacctt taaggagctt attttgtccg gcgaactgtt cggccatctg caaatcagca 777001 tttatcgggc ggcacttggt tttttgcttg gcgcggggct tggattgatg atcgggattt 777061 tggccggatt ttccaaacgg acggagctgt atcttgatcc gtcgttgcaa atgcttagaa 777121 ccgtacctca tctggccgtc acgccgctgt ttattttatg gttcggattt gacgaagtat 777181 ctaaaatttt gctgattgcg ctcggtgcct tctttcctgt ctatatcaat acgtttaacg 777241 gcatccgcgg ggttgacgcg aagctgtttg aagtcgcccg ggtgcttgaa tttaaatggc 777301 atcagcagat atccaaagtg atattgccgg cagccctgcc caatatattg ctaggcattc 777361 gcttatcgct cggcattgca tggctcgggc tcgttgtggc agagctgatg ggctcaagct 777421 cgggagtcgg ctatatgatc atggatgcga gacagttttc acaaacgaat aaagtctttg 777481 cagggattat catttttgca gtggttggaa agctgacgga ttccttcgtc aggctgcttg 777541 aacgaaagct gttaaagtgg agaaacagct acgaaggata aaagatataa aggggagatg 777601 aatatggaaa ttctttggtt tataccgact catggagacg cgagatattt aggatctgaa 777661 agtgatggac ggactgcgga tcatctttac tttaaacaag tcgcgcaggc ggcagacagg 777721 ctgggatata caggagttct tctgccaacg ggaagatcgt gcgaggaccc gtggcttaca 777781 gcgtcggcac tggcaggaga aacaaaggac ttaaagtttt tagtcgcggt aagacctggt 777841 ttaatgcagc cttctctggc agccagaatg acatccaccc tagaccgcat ttcagacggc 777901 cggctgctga tcaacgttgt ggcagggggc gatccgtatg agctggcagg cgatggcctg 777961 tttatcagcc atgatgagcg ctacgaggca acagacgaat ttttaaccgt ttggcggaga 778021 cttttgcagg gagaaacggt ttcctatgaa ggaaagcata taaaagtgga aaacagcaat 778081 ctgcttttcc cgccgcagca agagccgcat ccgcccatct atttcggtgg ttcgtcacag 778141 gctggaattg aagctgccgc aaagcataca gacgtgtact tgacatgggg tgagccgcct 778201 gaacaagtaa aagaaaagat agaaagagtc aaaaagcaag cggcaaaaga agggagatcc 778261 gttcgatttg gcattaggct gcatgtcatt gcccgtgaaa ctgaacaaga ggcatgggaa 778321 gcggcagagc gcttgatcag ccacttggat gatgacacca ttgccaaagc gcaggcagct 778381 ttgagccgtt acgactcttc aggccagcag cggatggccg tccttcatca aggcgatcgg 778441 acgaagcttg aaatcagccc gaatctgtgg gcggggatcg gcctggtcag aggaggggca 778501 ggaacagctc ttgtcggtga tccgcagacg attgccgacc ggatagcgga gtaccaggca 778561 ctcggcatag aatcgtttat attctccggc tatccgcatt tagaagaagc gtattatttt 778621 gcagagcttg tatttccgct tttgccgttt gaaaatgatc ggacgagaaa gcttcagaac 778681 aaaaggggag aagcggtagg aaacacttat tttgtcaaag agaaaaatgc atgagtttaa 778741 ctaaaataca gccccccgaa catggtatga tattcaaaaa aagggggctt tttttctgaa 778801 aacattgaga agcgcggcag tcatttgcct catagctatg ctgtcagcat gcggacattc 778861 aaaacagatg gaaatcaaag cggcggacat atcagatctt gaaaaaaaca gaatggatgt 778921 cgcagcttca caggcattca ctgccgaagc cgtcaatatc ggtgaaggta tttcttcagc 778981 tgacatgtac atcgaacatt atcaaaaggg aaagcttgtt gagaggtttg gaccggttcg 779041 tgcagattat tcagaggaaa aaactgatac catacaattt gtttattttg agaatgaaga 779101 gggggaagga aagaataaac ataccaccat tcattttggc attgtggata aacagggaac 779161 tatagcggct gattcatcgg tgaaacgcga cgatagcaca acacaggaaa tgactcagaa 779221 tatttcatcg ccggaaccga ttactttcga gaagcctgct ttgatcggca gcagtattag 779281 agggactgac gagacaatgc acacctctga acataaaaaa gagctcatta agcatcaaga 779341 tgcgttactg tattatgtgg aattgcatca ttagaatggg cggcttcagg ccgtctgttt 779401 tacaaagcgg tatgcttgct tttttgaatg gtgaatgata cattttaaat cgtaacaatt 779461 tcgatttaaa gggaggctat gtgacttggc taaaaaatca aaagtggcaa aagagttaaa 779521 acgccaacag cttgttgagc aatacgctgg tattagacgc gagttgaagg aaaaaggaga 779581 ttacgaggca ctcagcaagc tgccaagaga ttcagcaccg ggaaggcttc acaaccgctg 779641 catggtaacg gggcgcccga gagcatatat gaggaagttt aaaatgtcca gaatcgcttt 779701 cagggagctg gcccataaag gccagattcc cggtgtgaaa aaagcaagct ggtaagaaaa 779761 aactccggcc gattacagcg cgccggagtt tttttcgttt ttcttgaaag agatgacgta 779821 ggaaaggtgc tggatgatca tgatgataaa cacaataata atagggaaaa acggaatgcg 779881 cgattgaaat agcggataaa aaatgagaag aaccgctgcg gcaggcagcg agaagtagac 779941 agcgatatat gacgcgcgac atgcttttgc cgtcatcatc tgctctcttt catcctgctc 780001 ttcaaactca tcaggcagaa gtagctgctt tctggcaggg cggctttttt tctgtaagta 780061 caaataaacc gcagacgccg caacaaacag aataaaggga gtgaggttta aatcaaatac 780121 catcccgccg ctctttgtgc cgaaaaaaga tgctatgcct tctgaggctt caaagtatga 780181 aatcagcgcc cagcatgcaa ggccaaataa aacaaggtga aaagctgctt ttgttttcat 780241 gctcatctta gttttcctcc tctaaccaaa agacatcctc cattttcatg gagaaggctt 780301 tgcagatttt cagtgctaac agcagtgagg gaacataatc gcctttttca atcgctgcca 780361 cagtctgtct tgtgacgccg accgtttctc cgagtttttc ctgagaatag ccgaagcgtg 780421 ccctcagctc ttttacttta tttttcatca tgacgtctgt ccccttcaca atctcgattg 780481 attatattgt atagtatact taacattatg taaatggaac ttaacaactt tacaaaaaga 780541 taactttttt tcgacaaaat ttttatattc ccttgacgaa aaataaataa acatgtaata 780601 taaaaaaagt cagagcggta ctgttgctga caatcacaaa tgcgggtgta gtttagtggt 780661 aaaacctcag ccttccaagc tgatgtcgtg agttcgattc tcatcacccg ctccatacat 780721 acgttattaa cgcagtgttt cgtttctcag ataaacgaag tattgcgttt ttttatgtga 780781 aaaagaacac ggtattcgtg ttcttttacg taagccaatg tactgtatgg gtgccgccgt 780841 gaatttgttc aaacattttc gttaatgatg ataagaggtt aacagcgctg cttttctcaa 780901 tcgatggcgg gaaaaaaatg atttgcagca tattcttagt ctcgtttgaa acgggatagt 780961 ggttgacgct gtttttgaaa tcgccaaaaa tgccgttttc atcagagaaa agcagtatgt 781021 tttctttttc tcccaatgag atccggaccg gctcatgaag ctttccggca tcataaatca 781081 taataggcag agaatatttt aatgcgaaaa aatcgattgt gtcatgggcc gagtctttac 781141 tttccatgaa ttgttccttg gatatcggga ccagcatgtc ctccattggg gttgtttctc 781201 cctcaaatga agggttaagc tgtttaaaga gtttctgcca ttccttgacg aaggattcat 781261 cggatatacc gccgtccgca tagtcgaaaa acaaggattc ttgaaacagg cggagtctgc 781321 ctttcagcat ttgcggtgag gagccgactt cgatattctc ataaatgaca gcagctgcat 781381 gtaagccggc cgcacgttca gtaataacag aatcaagttt gatattcact agcattcact 781441 ccagttacgt gatatcaacc tattataaac gctgtgtcgt tttatcacaa agaaaggagg 781501 ctgtgcaaaa catgaacgtt tatcagctca aagaagaatt aattgaatac gcgaaaagca 781561 ttggcgtaga caagattggt tttacgaccg ctgatacttt tgacagttta aaagaccgtt 781621 tgattcttca agaatcactc ggctatctct ccggctttga agagccagat atcgaaaaaa 781681 gggtgacgcc gaagcttctt ttgccgaaag cgaaatcaat agtggcaatt gctctcgcat 781741 atccttccag aatgaaggat gcgccgagaa gcacgagaac tgagcgcagg ggcatttttt 781801 gcagagcttc ctggggaaaa gactatcatg atgtgctgag ggaaaagctt gatctgctgg 781861 aggattttct aaaaagcaag catgaggata tcagaacgaa gtcaatggtt gatacaggtg 781921 aattgtctga tcgcgccgtt gcggaacgtg ccggaatcgg attcagtgcg aaaaactgta 781981 tgatcacaac acccgagtat ggctcttatg tgtatttggc ggaaatgatc acaaatatcc 782041 cttttgagcc tgatgtgccg attgaagata tgtgcgggtc ctgcacgaaa tgcttggacg 782101 cctgcccaac gggagcactg gttaatcccg ggcagcttaa tgcgcagcgc tgcatctctt 782161 ttctgaccca gacaaaagga tttttgcctg atgaattccg gacaaaaatc ggaaaccgcc 782221 tgtacgggtg cgatacgtgc caaacggtat gccctctcaa taaagggaag gattttcatc 782281 ttcatccgga aatggagcct gatcctgaga ttgccaaacc gttattgaag ccgcttttgg 782341 ccatcagcaa tcgggaattt aaggagaaat tcgggcatgt ctcaggttct tggcgcggaa 782401 aaaaaccgat tcagcgaaac gccattctcg cgcttgccca ttttaaggat gcttccgcac 782461 tgcctgaatt gacggaactg atgcacaagg atccgcgtcc tgtcatcagg gggacagccg 782521 catgggcaat cggaaaaatc ggagaccccg cctacgcgga agagcttgaa aaagcgctgg 782581 aaaaagagaa ggatgaagag gcaaagctgg aaattgaaaa aggaattgag ttgctaaaag 782641 cttcaggcat gactaaacaa ggcctgtcct gacatacgta tagagcagaa ggaaaaaaca 782701 cttgagatca tccaagtgtt ttttctctat aaaaaagtat ggcgggtggg gtgagcttga 782761 agtacatttt agaacaatta gcggaggagc ggctgggctt tctggttaac gggcatgcta 782821 tgagacagga gtctcaagtc ggagacctta aagtcatgga gcgtaagaaa aagcttctgg 782881 aaaaacgtaa agttgacatc ataaaagcga aagcaaaggc cgtgattaat catgtgcggg 782941 ttgaggatga cggaacgacc tgcctttcgt ataccatcca ttacgaatac gtgtgtaagg 783001 aacaagatga cagcttgtat atagaagagc acatagagga gcgaatggct ttcctgtatg 783061 atcacatttt gattagtgat caggaaattg cgaaaaagcc ggctggattt catgaaggga 783121 ccagtattat tgactattct gaagctgaag aggaaagaga agcgtttggc agggcttttc 783181 aatacgatcg tctcggcgct gtccaatatg ccgagaaatt ttggaacaag cgcaatcctg 783241 cttataaaaa tttcagcgat aactgtacaa attttatttc tcagtgtctt catgcaggag 783301 gcgcgccgat gcgcggtcat ccgaacaggg gatcaggctg gtggatgaaa caaagctcat 783361 ggagctacag ctggacggtg gctcactcta tgaaaatgta tttgtcgaat tcaaaggccg 783421 gactgcgtgc ggtgcgggtg aaatcagcgg aagaactgat gccgggcgat gtgatttgct 783481 atgacttcga aggagacggc cggtttaatc atacaacgat tgtcgtggca aaggacaaag 783541 gcaatatgcc gcttgtcaac gcccagactt atgacagcag gatgaggtat tggtcatatg 783601 aggattctac ggcatacacg ccgtcaatac gatatgcctt ttttcatatc gttgatgata 783661 cgacaaaaga gtaattaatg ttataatgat gggcggataa gaaaaacaga ggtgaacatt 783721 gtggcattac atgtcgtttt atatcaacca gaaattcccg ctaacacagg gaatattgca 783781 cgtacttgtg cagcaaccaa tacaacgcta cacctgattc gtccgctcgg cttttcaacg 783841 gatgataaaa tgctgaagcg tgccggactc gattattggg agtttgttaa cgttgtgtat 783901 catgattcgt tagaagaatt gtttgaggca tataaaaaag gcaagttttt ctttattaca 783961 aaatttggcc agcagcctca tacatcattt gattacactg atcttgacga ggattatttc 784021 ttcgtgttcg gaagagaaac aagcggtttg ccaaaggatt taattcaaaa taatatggac 784081 cgctgcctgc gtcttccgat gacagagcat gtcagatcgt taaatctgtc caatactgcc 784141 gcgattcttg tttatgaagc gctgcgccag caaaattacc gtgatttaaa atagtgaaaa 784201 acccgctcat cgatgatggg cgggtttttt tgcggatgtt gaaatgcttt gtttcgtttt 784261 tgggcttaac aacgtaacag tgttatgtta caatgtaccc atcaaaggag ctggacttat 784321 ggaagaacaa ttaatctcta aaaaagaatt acttgaaaga acatcgattt catacggtca 784381 gctgtatcga tggaagcgga aaaacttaat acctgaggaa tggtttattc gtaaatccac 784441 atttacaggg caagagacgt tttttccgag agaggagatt ttaaaacgta tatcaatgat 784501 tcaaaagatg aaagaaaatt tgtctttgga tgaaatgagg gaaatgctgt cgccgaaaat 784561 gaaggatgtc agcatgaccg ctgatgaatt gcttcataaa ggtttggttt caaggcctgc 784621 tcttgaagcc tattcagaag acggaggaag tccggttttt tcatccagcg atttgctttc 784681 gctgtttgtg cttgagggcc tgctgcagtc tggaaatgtc agccttgcag aagcaaaaat 784741 ggctgcagag gtattaaaga agcatgatac tgaagagatt gaaaaacaga cggagctgat 784801 tgtgctccgc aagctcggtg tcacaacttg ttttatagcg gctgcggcgg acagcatttt 784861 gtttgaatca tccgtaaagg ttgtggaacg ggtagattta ttaaaagctt cagaggaatt 784921 aaaaacaaca tttatgcagg agggccatca atggatgtag tggaaaagct ggtgataaat 784981 ggatcaggaa gttctaaggg aggaacattt caatcagttg agattaatgg cagcgggaca 785041 gtggccgggg acgtggagtg tgacactttt tcttttaatg gaaacggaaa agcggacggc 785101 agcgtcaaag cgaaagcggt aactatcagc ggttcaggaa agatacatgg agacgttgaa 785161 gcagaatcta tccggatgaa tggcactggt tttattcaag gagaggtatc tgcaaaacaa 785221 ttgaaaatcg ctggatcatc aacatttggc ggcactgtca aggctgatgg aattgacatt 785281 agcggaaaag ctgtcatgga agcagattgt gaaacagaaa cctttcaatc agaagggaaa 785341 tgcaaaatca gcgggctttt aaatgcagac caggtgatca ttaagctttc tgcaggggaa 785401 agctatgcgc gggagatcgg ctgccgccat cttcaagtga cctgcagaaa aggaatgctg 785461 acattgctca gattgatgcc gcagcctgtt ctaacagcag agctgatcga aggtgacgtg 785521 attgaattga caaatacaaa ggcgaaaacc gtgcgcggta ataaagtgat catcggcccg 785581 gattgccaga ttgaaaccgt cgaatacagc ggggactata cctgtgatcc aagcgcgtcg 785641 gttgaaacat ccacaaagtt gtaaggagga tcgtaatgga gacaacaaaa ctgggaaatt 785701 taaaattata tggcgctggg catgccgcag gaggcgcgta tcacaatgtc agcatcaaag 785761 gagaaggtat agttggagaa gggctgtctg ctgtaggctg ccgcatatac ggaacgggcc 785821 tttttctcgg aaaagcagag actgagcggc tgcgtgtgct cggagaaagt gaatgtaaag 785881 gcgatctgac agccggcaaa atcaatatat atgggacaat gaaagtcagc ggctcacttc 785941 aatttgatcg attcaatctg aaaggccaga ctgaaattgg cgggaatatg actggagaat 786001 cctgcgatgt gaaagggaag cttagcgtaa taggtgattg tgaaacagaa atgttccatg 786061 tcacaggctg tgttgatgta tcggggttat taaattcggg tgagatcaag ctgggattga 786121 gccatgatat aagccatgtg caggaaatcg gcggaacaac aattacagtg aaaagacgcg 786181 cgagtttttt tagccggaag aaagggaagc tgatcgccga tgtcatagaa ggagatcggg 786241 tttatttgga gaataccgaa gcggcagttg tcaggggaaa agaagtgatc atcgggccgg 786301 gatgcagcat cggaacgatt gagtacgaat acaaatgtga atgcgatccg cattcacaga 786361 ttaaagaaaa aacaaaactg taaaacattg ttctgttata caaaaagggt gctctttcag 786421 gagcaccctt ttttattctt ttccaggctt gctttcgtat cctgcggtaa aaattgatac 786481 taaaaaagtg acaatgacac ccatcatgat gattgttttc accgtctctc cccctcttca 786541 atttttccgt gctgtccgag tctggatgat tctgtatttt tctttattat gaacggtcgc 786601 agtctgcctt gtcaacgatg tatgagtatc tttattttta agaaaccaaa gcatgtatca 786661 cgagatggcg gcatagattg tatcaaagta ccttatttgc atagtgtatc aaacatgata 786721 gaggaggtcc ttatggatat attaaagaaa attgaaaagt acagagagga agagcagcgg 786781 ctgaaatggg aaggaacttt cgccgattat ttggagatta ttaaagaaaa tccgatggtc 786841 gcgcaatctg ctcattctcg agtttttaat atgataaaag acagcgggat agaggagatt 786901 gacggacgca agaagtacag tttttttgac cgcgagctgt tcgggcttga agaatctctg 786961 gagcgtcttg tggaagagta ttttcatccg gctgccaaac gtctagatgt cagaaagcgg 787021 attctattgc tgatggggcc tgtgagcggc ggtaaatcca cgctggtcac aatgcttaaa 787081 aaaggtctcg aagcgtacac gctgacagat aatggcgctg tatatgcgat taaaggctgc 787141 ccgatgcacg aggaccctct acatttaatc ccccatcatt tacgcgatga cttttacaga 787201 gaatacggca ttagaataga aggaagtctt tctcctttaa atgtcatgag gctggaggaa 787261 gagtacggag gaagaattga ggatgtgaag gtggagcgca tcttcttttc agaagataag 787321 cgtacgggaa ttggaacatt cagtccctct gatccgaaat ctcaggatat tgccgatttg 787381 acggggagta ttgatttctc aacaatcgcc gagtacggtt cagaatcaga tccgcgcgct 787441 tatcgatttg acggagagct gaataaagcg aaccgcggga tgatggagtt tcaggagatg 787501 ctgaaatgtg atgagaaatt tctctggcat ttgctttcct tgacacagga agggaatttt 787561 aaagctgggc ggtttgcgtt aatttctgct gatgagctga tcgtggctca cacgaatgaa 787621 acggagtatc gctcatttat ttctaataag aagaatgaag ccctgcactc aagaatcatc 787681 gtgatgccgg ttccttataa tttaaaagtg tctgaggaag agagaattta tgaaaaaatg 787741 attgcagaaa gcgatgtggc ggatgttcat attgccccgc atacgttgaa ggtcgccgcg 787801 atgttctcaa tccttacccg gttaaaagag ccgaagcggt cggatattga tctggtcaag 787861 aaaatgagac tgtatgatgg ggaaagtgtg gaaggatata actctgtcga cgttgaggat 787921 atgaaaaaag aatataatga tgaaggcatg agcggaattg atccgcggta cgtgatcaac 787981 cggatttctt caacgattat cagaaaaaat atggaatcga ttaattctct cgatgtcctt 788041 cgctccttaa aagaaggtct tgatcagcac ccatcaattt caagcgagga cagggagcgg 788101 tatttgaatt ttatctctgc cgcccgcaag gaatatgacg atattgcgaa aaaggaagtt 788161 caaaaagcgt ttgtttattc atatgaagaa tcagcaaaaa cacttatgga caattacctc 788221 gataacgtag aggcctattg caataaaaac aagcttcgtg atcctttgac aggagaggaa 788281 atgaaccctg acgaaaagct gatgagatcc atcgaagagc agatcggcat ttcggaaaac 788341 gccaaaaaag cgttccgcga agaaatttta atccgcatct cggcctatgc gagaaaaggc 788401 aagcggtttg attacaattc ccatgaaaga ctgcgtgaag ctattcagaa aaagctgttt 788461 gctgatctga aggatgtcgt taaaattacg acctcaacaa aaacgccgga tgagcagcag 788521 ctgaaaaagg taaatgaagt cgtggcccgt ttaattgatg agcacggcta caactcgacg 788581 agcgccaatg agctgctgaa atatgtcggc agcctgctga accgataagc aacgtgaccc 788641 gtccgaatag ggcgggttat tttgtcccat tttctaaata gtttgtcaat taaacgtgca 788701 tatgtgcata tgatgaatat aaatcttttc aaaagacttg tttcataatc tggcacaagc 788761 cggaatacgt atgtatcacg accacaaatg gttaaggagg ggaattcatg tcccaaaatg 788821 acagcggcca ttttttgatt tctgaggaaa actggtccct ccatcgcaaa ggcttcgatg 788881 accagcagcg ccaccagaaa aaagtgcagg aagcgatcaa aaacaatctt ccggacctcg 788941 taactgagga aagcattatt atgtctaatg gaaaagatgt agtgaagatc ccaatccgtt 789001 cacttgatga gtataaaatc cgttataact atgataaaaa taaacatgta gggcaaggag 789061 acggcgagag ccaggttgga gatgttgtgg cccgggatgg atcagacaaa aaacaagggc 789121 ctggaaaagg gcagggtgcc ggtgatcagg caggcgagga ttattatgaa gcggaagttt 789181 cattaatgga tttagaagaa gcgcttttta aagaattaga gcttccgaat ctccagcaaa 789241 aagagcggga caatatcatt catacagata tcgagtttaa tgatatccgt aaaacagggt 789301 taaccggtaa tattgataag aaaagaacga tgatgtcagc ctttaaacga aacgcaatgt 789361 caggaaaacc gtcgttctac ccaatttatc cggaggacct gaaatataag acgtggaatg 789421 acatcacaaa gcccgaatca aaagccgtcg ttttagccat gatggataca agcggcagta 789481 tgggggtttg ggaaaaatac atggccagaa gcttcttttt ctggatgacc cgttttttgc 789541 ggacaaaata cgagactgtg gaaattgaat ttattgccca tcatacagaa gcaagagtgg 789601 tctcggagga ggattttttc tcaaagggag aaagcggcgg aacaatttgt tcttccgtat 789661 atcggaagtc gcttgagctt attgatgaaa agtacaatcc cgcccgctat aacatttacc 789721 cgtttcattt ttctgacggt gacaacctga catctgataa cgcgcgctgt gtgaagctgg 789781 tcaatgatat tatgaagaag gccaatctgt tttgctacgg cgaggtcaat cagtacaaca 789841 ggcattcaac gttaatgtct gcatataaaa atgtaaaaga tgagaaattt aagtactata 789901 ttttaaaaca gaaatctgat gtttttcagg ctctaaagaa ctttttcaga aatgaagagt 789961 ctggtgtaag ccatcaattt tcgtaatgaa aagcccattt cagggctttt ttttatttaa 790021 taaaagcaag aaaacgcttg cgaaaaaaat acgggagaaa aagaaatttt tcctttgaca 790081 aatcttcttt catttattaa tattttatct tgtgaactat tattgaggaa tgaggtgaaa 790141 aggagttgac tgaatcagaa cgtgctttgc tcacttttga acagctcttc gatacgtctc 790201 gggcgatata taaaaaacag aagaagatat tggagattgt gcttgagcct tttgatatta 790261 cagtccttca atatttgctg atgtttaaaa ttcatcaaag cggaagcacc ccgctaagca 790321 agctggcaat gtcgcttgat cttaagcctg cttctgtgac gcggatgaca gatattctgt 790381 ataagcgcca attgatgaat cgatatgaca gtccggatga ccgccgtatc gtcatgattc 790441 agttaaccga agagggggaa gaactgatag aaaaagccgc tgtgcaatat gcaaaaatgg 790501 gtgctggctt gtaccaaaag cttgatacct cccagctgca gtatttgcgc aaactagccg 790561 gaagtttaac gaagcttgct gaaggctgtt cagaaaaaag cggtaattaa aaacttctca 790621 catattttca ccagctttcc gcaaaatgat agaggatgaa acgaaaggag aaaacaaaat 790681 gaacagagga cgtttaattc tgaccaacat tatcggtttg attgttgttc ttgcaattat 790741 agctggaggt gcttactact attatcaaag cacaaactac gtaaaaacag atgaagcaaa 790801 agtagcgggc gatatggctg ctattactgc tccagcagca ggtaaagtat ctgactggga 790861 tctggacgaa ggaaaaacag tgaaaaaagg cgacacagtt gcaaaaatca aaggtgaaca 790921 aactgttgac gtaaaatcca ttatggatgg cacaattgtg aaaaacgaag tgaaaaacgg 790981 acaaaccgta caagctggta caacaattgc acaaacgatt gacatggaca acctatacat 791041 cacagcaaat attaaagaaa cagatattgc ggatattgaa gtaggaaata gtgtagacgt 791101 agtagttgac ggagaccctg atactacatt tgacggtact gtagaagaaa ttggttatgc 791161 gactaactca acttttgata tgcttccttc tacaaattca agcggaaact acacaaaagt 791221 aacacaaaaa gttcctgtga aaatttcaat caaaaaccca tctgataagg tgcttcctgg 791281 aatgaatgca tctgttaaaa tttctgagta aaacagatca gtcatcaaac catgaaagga 791341 ggttgtctta gatggctaca ggcaaagaaa aaaatgcaaa aaaccctatg tcattgctga 791401 ttgtgctaat ggcgggttta tttttggcaa ttctaaacca aacactgctt aatgttgcaa 791461 tgccgcactt aatgactgaa tttggcgtaa gtgcaacgac gattcagtgg ctgacaacag 791521 gttacatgct tgttaacggt gtattgattc cgttatctgc tttcctgatt acacgatttg 791581 gccagcggag tctctttctc gtcgcgatgt tttgttttac gctcggtacg ttagtctgcg 791641 gtatcgcacc taacttctct acaatgctga tcggccgttt gattcaggcc gtgggcggag 791701 gtatcttgca gccgctcgtt atgacaacca ttctgttaat tttcccgcct gaaagcaggg 791761 ggaaaggaat ggggattttc gggctagcga tgatgtttgc tccagcggtc ggcccgactc 791821 tttccgggtg gattattgag cattatacat ggcgcattat gttttacgga cttgtgccga 791881 tcggcgcaat tgttatcatt gtggctttct tcatctttaa aaatatggtg gagccgcaaa 791941 aaatcaaact cgatactctt ggcgcaatcc tctcgattgt cggattcgcc tccttattat 792001 acggagtcag tgaagccgga tctgacggct ggaccgaccc gattgtattg tctacagtta 792061 ttatcggagc cattgcaatt gttgcttttg ttgttcagca attgcgtcat gatgatccga 792121 tgcttgattt cagagtgttt aaatatgaca ttttctcact ctcgagtgtc attaatatca 792181 ttattacagt ggcactttac actggtatgt tccttttacc gatttatctg caaaacctgg 792241 tcggctttac ggcgcttcaa tccggtctgc ttctgcttcc gggtgcgatc gttatgctga 792301 ttatgtcacc gatctcaggt attttgttcg ataaattcgg accgagaccg cttgcgatta 792361 tcgggcttct cgtgacagtg gtaacaacgt atcaatacac gcaattgaca attgatacac 792421 catatacaca catcatgctg atctattcaa ttcgtgcatt tggtatgtct ctcttaatga 792481 tgccagtcat gacagccggg atgaaccagc ttcctgcccg tctgaacagc cacggaacgg 792541 cgatgagtaa cacgcttcgc caaatcagcg gatcaatcgg aacaagttta attacgacga 792601 tttatacaaa ccggacgaca ttccattatt cacaaattgc agataaaaca agcacggcgg 792661 acccgaactt cctccatgcg ttccaaaatg cagtttcgaa tttaatggtg aatatgaatg 792721 tgtcttatga tacggcgaaa acatatgtgt actcacatat ttataaacac gcatcactcg 792781 attccaatgt catggggata aatgatgcct ttatgtgggc aaccttattc tgtgtagcag 792841 gtttgatttt aagtatcttc ctgcgtgacg tcagaaaaga taaattgcgt aagaagaaaa 792901 aagaggagct ttcattactt cctgctccaa aagaagctaa ggaatcttaa tctgtacagg 792961 gaggtttcct gaatgaaaat ttatgtagtg tatgatagtg aaggcgaaca tactaaagtg 793021 cttgcagaag cgattgctga aggcgcgaga gaaaacgacg cggctgaagt gttcatcgac 793081 catgtagatc aggctgatat ccgcaagctt aaagatatgg atgcgattat ttggggatgc 793141 ccagggcatt tcggaacaat cagctccggt cttaaaactt ggatcgacag acttggctac 793201 ttgtgggctg aaggcgagct gatcaacaaa gtcggtgctg tcttctgcac aacggcaaca 793261 acacacggcg gcttggaaat gacaatgcac aatttaatca cgccgatgtt ccaccaaggc 793321 atgattgttg tcggactgcc tggcaacgtg cctgaaaacg cactttatgg ctcttattac 793381 ggagcaggtg tcacttgtcc ggtagacagt gatgagttaa tgtctgagga aggtattcag 793441 cttggacgcg cgttgggaag acgtgtcagc caagtcacag gaaacctaac agcaggacag 793501 taaggagagg ttgaaatggc cattattata gcaataattg ctgctgtcat tgtcattgcg 793561 gcccttatta catttaacgt ccgcaacgcc tcacctggac ctgagaagca agaagcaacc 793621 gatagaatcg cacctccaga agaggaaaaa aacgaagcgc attaccctgc tgaagcaagg 793681 gctgccgagc atacgccatc cgttgtcaaa aacgattctc caaaagagaa gcgtgacaca 793741 atgggtgatg atatttacag gcaggcgctg caaaagttta agcattctga tgaagttcat 793801 gcagaagaag aggtcactga ggaaagtgac aaaatgcagg accgcagcta tcgtgatgcg 793861 ctgctctcta tgaaaaataa gaaaaagtaa tgaaaaaggc aaatccgttt actcatgcgg 793921 gtttgccttt tttgctgttt ccatcaatta tgtttttatc aaataaatcc atggaatatg 793981 ttgtattcca ccttgatcta gtgtactatg ttactcatac accgaggatt ttttccggga 794041 ggtaaagaca tgaattcttt tttaggttta ttaaagaaag atatcaagct ttcaagaatg 794101 tggctgctag tatggatatg cggaatcatt ttcttattgg gaacaggcca tattatagct 794161 tctcgcacga aagaacctct agtcattttt ggtttttttg ttgcagttgc tttttttctg 794221 cttttcttat ctcctgtttt tgttttttat caccttcgca aggaagggaa atcacagctt 794281 tggctgtaca atccaaatgg cggcttatgg ctgttttctt ctaaattggc agcatctttg 794341 ctctatcaat ttgtgattca gttggcatta acagcctatg gcatatggat gtatcatatg 794401 ctctctgtaa aaaatctgct ggagcatcaa gttgatataa cgagtacagt ggctttgctg 794461 aatatgtatg ggcttatttc ttcgttagat atgtcagtaa cagtcattgt gttttggact 794521 gtttttcact ctctcagaaa ttggcgcgga atgcggtggg ctgcgatggt tctgttggtc 794581 gcaatgtggt tattcttcga tgaatacatc ataagccctt tggttgaatc tcaaaagcat 794641 ttctggcctg taacagtcta ttgcaatttt gatttccact tccacaatgt ttggagattg 794701 gaactaaaac ctatccatct gtctgtgcta gggtttccta ttgctatagt catcacattc 794761 ttgctgctca tcatggcttc aaaactgctt gatcgtaaag tagaggtgta aatatggaca 794821 atcaattcca atcctcgaaa ccgatttatc tgcagatcgc tgatcagatc ttttataggc 794881 tggtcaggaa ggagctgctc ccaggagaca agcttccttc agtaagagaa atggcgattc 794941 aaactaaagt aaatcccaat acaattcaaa gaacttacag tgagatggaa aggctgggta 795001 ttgtggagac aagaagaggt caagggacgt ttattgcgga aaaagcagaa atcgtagacg 795061 agctgaaaga caagctgaca cgagaggtgc tggaaggctt tgtcaagcaa atgaaagagc 795121 tggggctaac gaaagaagaa atgttagaag ggattaaaac attcacagag ggaggctaaa 795181 atggaaatca agctagaaca tgtatcaaaa aaatacggcc gccatacggc cgtcaatgat 795241 gtgtcaatca ccctatcatc cggacggatt tatggcctga ttggaccgaa cggcagcggc 795301 aagtcaacga ccctgaaaat gatggctggc cttctgtttc cgacttcagg atttgtaaaa 795361 gttgatgaag agcaggttac gagagaaatg gtgcgtcaaa cggcttatct tactgagctt 795421 gatatgtttt atccgcattt cactgttaaa gatatggtga atttttatca gtcgcagttt 795481 cctgattttc atacagaaca ggtttataag ctattgaatg agatgcagct gaatccggaa 795541 aaaaagatca aaaagctatc aaaaggaaat cggggcaggc tgaaaatcgt tcttgcttta 795601 gcgagacggg cagacgtcat cttgcttgat gaaccttttt ccgggcttga tccgatggtc 795661 agggattcca tcgtaaacag ccttgtgtcg tacattgatt ttgagcagca gattgtcgtg 795721 atcgcgacac atgaaattga tgaaattgag actttgttag atgaagtaat catcctcgcc 795781 aatggagaaa aagttgcgca gcgtgaagta gaagatattc gtgaacagga aggcatgtct 795841 gttttgcaat ggtttaaatc aaaaatggaa gtttgctaga aagaggagga atatgatgaa 795901 aacagtgttg gaattgaaaa acgtgactaa aaacatcaga ggccgaacga tcattgatga 795961 tctcagtttt acgattcgtg aaggcgaggt attcggtttt ttaggaccaa acggagcggg 796021 gaaaacgaca accatccgga tgatggtggg gttaatgaag ctgtcgaaag gtgatgtcct 796081 catttgcggc caatcaatta cgaaagaata tgccaaggcg attaagcata tcggagcgat 796141 cgttgagaat cccgagctgt ataaattttt gagcggatat aaaaatctcc agcaattcgc 796201 aaggatggtc aagggtgtca cgaaggaaaa aattgatgaa gttgttgaac tggtcggttt 796261 aacagacaga atccacgaca aggtgaaaac atattctctg gggatgagac agcgtcttgg 796321 cttggcacaa tgccttctgc acgatccgaa agtgctgatt ttggatgaac cgacaaacgg 796381 ccttgatccg gcggggatca gagaaatcag agatcattta aagaagctga cccgagaaag 796441 aggaatggct gtcatcgttt caagccacct gctgtcagaa atggaactga tgtgtgatcg 796501 aattgcgatt ctgcaaaaag gaaagctgat cgatattcaa aatgtaaaag atgaaaacat 796561 tgatgagaat gatacatatt tcttccaggt tgagcagccg agtgaagccg ctactgtttt 796621 aaatcagtac gatttgctga gtaagacaaa tggtgtagaa atcaaactgg ctaaagagga 796681 agtccctgcg gttattgaat tgctggtgat gcagcaaatc cgtatttatg aggtcaaggt 796741 cataacaaaa tcattagagg accgtttctt agaaatgaca ggtgaaacaa aagaggaggt 796801 tcagcatgct taatttgatt tataatgagt ggctcaaaat tttcagccgt gccggaacat 796861 gggtgatgat cggaattctg gggctgacaa tggttggatt tgcatttttg gcgaatcatt 796921 tttctgccgg tgaatcaaat tcccattgga aacaagagct tcaagcacaa aacgccgaat 796981 taaagaaaga aatcaaagaa gatccttcac tgaaagatgg gtataaagaa acaatcacac 797041 tcaatgacta tcgcatcgag cataatatcc ctagtgacac gggctatacg gtatggtctt 797101 atgtaacgga ttcagcaaac tttaccatcc ttaccggtct gtttactatt atcatcgcgg 797161 ccggaattgt cgcgaacgaa tttaattggg gaacgattaa gctattaatg attcggccgc 797221 tcagtcgttt tcaaattttg atgtccaaat atattacagt tctcctgttt gggctcctgt 797281 tgctgttgat tttatttatc ggttctactt tattagggtt gatcttcttc ggaacgggtg 797341 gtgaaaccgc cgcgaatatt catttaatct ataaggatgg ccatgtcatt gagcaaaaca 797401 tgatggggca tttggctaca acgtatcttt ctgaatccgt ctcggcttta atggtggcga 797461 cgatggcgtt tatgctgtct gcggtattca gaaacagctc tcttgcggtt ggtttttcca 797521 tcttcttgtt ggttgccggt acgactgcaa ctgcatttat tgcagcgaaa tttgactggg 797581 caaagtatat attgtttgct aatgtcgact tgactcagta tgtggatggc acaccgttaa 797641 taaaagggat gactatgacg ttttctctcg tcatgctggc gatctacttt atcatcttcc 797701 tgttgcttgc tttcggaatc ttcatgaagc gggatattgc aaactaataa aaaaagctgt 797761 tttgcttatg caaaacagct tttttgtcaa aataaaaact gcaggtttgc acctgcagtt 797821 tttcatatca atttatgctt acgcttcttt agtaacgtta gcagcttgtg gtccgcggtt 797881 tccttcaacg atttcaaaag aaacagcttg gccttcttct aaagttttga agccttcgcc 797941 ttgaatagca gagaaatgaa cgaatacatc gtcttgacct tctacttcga tgaatccgaa 798001 acctttttca gagttgaacc attttacttt accttctaac atgaaatttc ctcctaaagc 798061 gatcataacg cttaaattca ctattcttgc tcttaacaaa ctttcaagac gaaaactctt 798121 acaaaacttt cttcttaaag atagttcgaa caaaaataat tacctttact ctaccagtaa 798181 tcttcagaaa aaacaactgc ttattgaaat ttttttcgga aaataccata tttatttttc 798241 aatttgatat ttatttacgg aaattcatct gttttctcga tatgtgatca tacgtttgcc 798301 ttagtattcc ttcattttgg gaagataagt aataggaatt gacaacctta ttggatatga 798361 gtaaggtaaa agttaatcaa tattacaaat gacaacgttt atcaactaag agagcgtatg 798421 atttttatgt ctgatattgc ttgcatgctc taatacatag ataggagtat ggtcacaatg 798481 aaaaagtggc ttatatgcag tttcgtcctt gttcttctcg tttcatttac tgcatgttca 798541 ccgtctgcag aacatgaatc gataaaaatc gggattgctg agtctgacgg ggcaatatgg 798601 aactatattg ctcaaaaggc tgaagaggca gggctggata ttcagctgat ccctttttct 798661 gattatgcgg agtctgatat cgcacttgct aacaaagaaa ttgatgccaa cgcctttcaa 798721 accatttcat attttcagtc gttcactgaa aaatacaaac ttaatttggc accgctcggg 798781 acgacataca taacgcccat gggcatttat tcaaaacgat atgaacgaat ccgagatata 798841 tcgcggggag ctgtcgtttc tgttccggat aaagcgttcg attttggcag ggcgcttacg 798901 gtgctccagg aagcgggttt gctaacgctg aaaaacggat ttaacggaac aggttcagtt 798961 gatatgatta aagataatcc gagacacctg aaattaaaag ctgtccggca acaggatgca 799021 gtgagcggtg ccgacgtgtt tgtcatgaaa ccatcagaag caaaaaaagc gggcttgaac 799081 ccgaaaaagc atacgctaaa gagcggcgga ctcatgtctg aggaagagat gaatttgatt 799141 gttgtcagag cggaggatca agatcgggaa gcgctgcaaa ccattcttga gctttatcaa 799201 gctgatgata cagcggcatt tatagaaaaa gaatatcagg gagatcttgt cccggctttt 799261 ctgcctttga aacgtctttc agattggaag aatgaattcg aacattgaat tcattctttt 799321 ttttctgaaa aacacactct gttccgtccc gtttctttcg ctttgtaaag catttgatcg 799381 gcaagaatgg gcaaggatcc tggctgttcc gtattattgg ggtaatgagc ggcccctagt 799441 gatatcgtaa ctgaaagctc gtcgccgttt gttaatacaa tcggtgcatc acttacagtg 799501 ctcctgatcc gttcagcgat ccgggctgct ttatcaagag aacagttcgg caggagcacg 799561 gcaaattctt caccgccgat ccgagcggca ggatcagtat ttcggatggt ctgcttcaga 799621 cgtaacccta gctctttgag cacctgatct ccttcatgat ggccatattg gtcattgatg 799681 gtcttaaaat gatcgatatc catataaatc agtgcaaatt gaaaatgcgg ggtatcggcc 799741 gcctgctgat acagagcttt tgtggtttct tcaaattttc ttcggttata cacgcctgtt 799801 aaaaagtcaa agtgcgcctg aaacttatat tgtttaaaaa gaagatgtgc atttgtttca 799861 tgatcaataa tatataaact gagcatgccg cccgctattg atatgatcca aaaatacaaa 799921 tgaagttcgt atgaatgtaa atctataaga aaataaaagg aaaaggagat caagctattt 799981 gtgattatta aaagatagaa agcatgtttt agttgaactt tttttcttct agaaacaatg 800041 agtgacggaa tggcagcgat acaaatgata ataaccgagt atagtgcaga tgtgttcatc 800101 gtaatcagca agcggcctgc agtgatcatg gccagggccg ttgccgttga aacccagcct 800161 ccataaagag cggcaatcat aatagggata tttcgaagat caataattga atgctgatag 800221 gtaaatccaa aaaccatcag aataaccccg agcaaaccgc aggccagtcc tttaacagct 800281 tgaaaggata tgctgtcttt tttatgtact agcctttctt taaacaggtg ggtgaagaga 800341 taattaaatg tgattaaaat ggtcaaattt acaaacagtt ctttcagcaa atattatcac 800401 ccttatataa ggtactaaag atggaaggga aagaaaagaa caaaaaaggc attatataag 800461 gtttttttac ttgaattgat aagttaaaat aattcgcact tgacccatcg gaattagtgt 800521 aatatagtaa atgagaaaat ttgaagggag agtttacctg ctttggagac tttactggtt 800581 gtattacatg tatttatttt atttttactt atcttagggc tctttgttat gcagaaaaaa 800641 catgtttcct tctctaaacg tgtatttact gcgctggggc tggggattgt attcggattt 800701 gcgcttcagc tgatttacgg cccgacttca aatatagtca ttcaaacagc cgactggttt 800761 aatattgccg ggggcggata tgtcaaattg cttcagatgg ttgtcatgcc gctcgtcttt 800821 atttcgattc tcggcgcctt tacaaagctg aagctgacaa aaaatcttgg gaaaatcagc 800881 ggtttgatta tcgggatttt agtagcaaca acagcagttg ctgcagctgt cggtatcgcg 800941 tccgcgcttt catttgatct gcaggcgatt caggttgacc aaggaagtac agagctttca 801001 cggggacagg agcttcagca gaaatcagag gatatgacag cgaaaacgct gccgcagcag 801061 attgttgaac tgctgcctgg aaacccgttt ttagatttta cgggagctag accgacttca 801121 acgatcgctg tcgttatttt tgccgctttc cttggagtgg cattcctcgg cgtaaaacac 801181 aaacagccgg aacaggcaga aacatttaaa aaactggttg atgccgttta tgccattgtc 801241 atgcgtgttg tcacactcat tttgagactg acgccttatg gggtgctggc catcatgaca 801301 aaaacaattg caacgagtga tcttgacagc attctaaaac tgggcatgtt cgtgattgca 801361 tcatatgccg cgttaatcac tatgtttatc attcatttgc tgctgctgac gttcagcggc 801421 ttgaatccgg tgatttattt gaaaaaagcg gtgcctgtac ttgtatttgc atttacgtca 801481 aggtctagcg caggtgcttt accgctgaat attaaaacac agagaagcat gggtgtaccg 801541 gagggaatcg caaactttgc cggttcgttc ggtctttcga tcggccaaaa tggatgtgcc 801601 ggcatttatc ctgcgatgct ggcgatgatg attgctccga ctgtcggcca aaatccattt 801661 gacccggtgt ttattatcac tgttatcgca gtcgttgcca tcagctcctt cggggttgcc 801721 ggagtcggcg gcggagcgac attcgcggcg cttcttgttt tatcatcatt aaacatgcct 801781 gtcgcgctcg ccggtttgtt aatctcaatt gaaccgttaa tcgacatggg gcgtactgct 801841 ttgaatgtca gcggaagcat gacatccggt cttattacaa gtaaggtcac aaaagaaatt 801901 gatcaagggg catttcatga tcaatccaga gtgattgaag ctgaagaagc gtaacatatg 801961 aaaacgtgta atccaagagg attacacgtt tttttaacgg ccaggctcta agtcctccag 802021 catttccatc atcgtgttgt cgtccatgac attcattgcg ttttgttcaa aatgaatggg 802081 ttcagcataa tgcggctgtc tttttttcgc ggctgtctca gtttgcctag tttgagactg 802141 tgtatgctga tgctgtggtt gctgctgtcc agcgtgctgg tgctgacggc cattttgccg 802201 ctggctttga tgctgcgaac ggtcctggtt atcaccgctg cttccgctgc ttccgctaaa 802261 tgcttgtttg accatgtttc ctacattaga agcatcaaac gtgttatttt ctgaatttcg 802321 tctgttcatt tgtcctgtga taaacccgct gattctttgg cggatctgag gtgataatgc 802381 agtaataagc atagttgatc ctatgatcaa tgctgcgggg ctgattcctc ttcgctggtt 802441 gaacaacatg atccctcctt tgcagtgtat tcatattttc cccctcgtta gacaaattaa 802501 ccgttatatt tcccgggaaa gcatttcctc cagatttgca tgcataatta aagccagtta 802561 gaaaaaccta taagtaaagt gataaaggag gaattcacat gtttggaaaa aaacaagtcc 802621 ttgcgtctgt gcttcttatc cctttgctta tgactggctg cggtgtagcc gaccaaggtg 802681 agggcagacg tgataataat gatgtaagaa acgtaaatta tcgaaatccg gccaatgacg 802741 atatgcggaa tgtaaacaat cgggataacg ttgacaacaa tgttaatgat aatgtcaata 802801 acaatcgtgt aaatgacgat aataacaacg accgaaaact tgaggttgct gatgaagcag 802861 ctgataaagt aacagaccta aaagaagtaa agcatgccga tatcattgtg gctggaaatc 802921 aagcctacgt tgcagtcgtt ttaaccaatg gaaataaagg tgcagtagaa aacaatctga 802981 agaaaaaaat agccaaaaag gtaagatcta ctgacaaaaa cattgataat gtttacgttt 803041 cagctaaccc tgattttgta gagcgtatgc aaggatatgg aaagcgtatt caaaatggtg 803101 acccaatcgc cggattattt gatgaattta cacaaactgt acagcgtgta ttccctaacg 803161 ctgaataaat gaaagaagcc gcacaatttg tgcggctttt tctttgcgtt aatgacacac 803221 tgcgaactca ggctgcatag agtaaaaata aaaaggtaca agacggaccg gctcagggag 803281 ggagacgttt gcgggatggc ataggaaagc gtgcggcatc cgctctattc ctgtgcggag 803341 tccttgtgat gctggctgta agctcagcca tcgtatcaag cgcgatgtat atcctgtctt 803401 ttccaggtca ggcatctgga ataacaaaag aacaagtgac gaagcacatg aagaaagagt 803461 cattcaaaca ggccgatatt tattacactt ctaaggaaaa gtccttactg ccattgacga 803521 aagaaacgct tgaatatgcg gtcagtatta atcagattat gattggatat tcgaatcaaa 803581 agcctattga cattattttt tttcctaatg aaaaacagat ggaggcttac tccggtttat 803641 tggatgtagt tggtttttat tctgaacggg agcagctgat cggattgttg cctgaagaga 803701 aaaagaaact gttagaaggg gacgaggtag cggtttattt gtaccagaga ttgttgattc 803761 atgaatactc gcaccatgcg tttcaccaga aattgaagga gcttgagacg gatcccgatg 803821 agtttccgtt atggtttcat gaagggttaa gcgagtggat tgcgaactat gaattgctca 803881 tagatccgat cacgttttct gtcgtgccct ttgaccgttt gcagactgat cgagactggc 803941 aggaagctag agccgaatat gacactgatg tctatttgca aagcttttat atgatcgatg 804001 agctgacgga caaatacggg aaagacatta tttcagaaat gattaaggaa acggcaaaaa 804061 aaggggactt tgaaaaaggg tttaaatcag caacaaagga aagtcttgat caatttgaaa 804121 aagattttaa gaaaaaattt gaaaaaaaca gtgcggcatt ggatagtatc tatccaatgc 804181 ctttgttatt agtgaagtcc ttgctgaccc attccgcctt gtgtcggagg catttgtcct 804241 tgggcagggg cgaatgaatt tcgcagctgt tccatatcct gcgcatcaag ctgaggaacc 804301 tggtaatagc cgtgtttgtt ttggtatagg aaaatttcaa atgccatttc aacatactcc 804361 tgaatttgcg cagacagtac gcgtcttacg gccggatttg tcatttccag agaagccatc 804421 gtcagcatag aagcttgtgc tttaatcgcg caaagcattt gtcggctgat gatgctgtca 804481 tcaatatcat tcatggattg aacaggtttt ttaggctgtg acggctgcat gccgtaaaca 804541 gtctggttgt cttccttcat catataagtt gctgtttttt gtgaaggttc gcttcctgtt 804601 ttgaagcatt ctgcagttat attgtattga gatgtgatga attgatgttg acgatcaagg 804661 atgtttagta attcttgatc cttacagaat tgtctcagca tcataaactg atcaagcaca 804721 gtaagtgttc cggaaagcac ctcatgcata tcaaacattt catgtccgcc gtggttttta 804781 tgcggtttgc caggaatacc tttgttcatt tgggattgct gctgctgatt gaactgatcc 804841 aaaccgaatt cctccttttt tttcagatca gctgtatttt gtgtcagtct gccgtgtatt 804901 atgcagaagc ctgaaaggaa ttatatgctg tctgtcgaaa tgataagcag acaaaatcgt 804961 tgtcattatg tgtataaggg aggaaatatg atgaggcgta ttctgcatat tgtgttgatc 805021 acggcattaa tgttcttaaa tgtaatgtac acgttcgaag ctgtaaaggc agctgaaccg 805081 caacagccta tatcgattga gaaggcaata cagcaaaaag aaggacaggc acttgtcgaa 805141 ggatatgcag tcggccaggc tgtttccccg cagcattata aactgacaag ccctttttca 805201 aatgattata atgttgcgct ggcagaccgt aaaaacaaaa catcgcccga acacatcctt 805261 cctgtgcaaa tcccctccgc cttcagaagc caatttgggc tgcaaaccaa tccgcttctt 805321 cttgggaaaa agataacggt tcaaggaaag cttgaaaatt actttaacac gacaggactt 805381 aaaaacgttc agtcgatgaa cgtaaccgat gacacaaaaa ctccgccggc tgaacagcaa 805441 gtgaccataa atgaagcacg gggaaggctg aatgaagaag taacgataaa agggatcatt 805501 acagctgatc aaaacgcaat cggaggcggg aagctgtcga cctttttgca agatgaaacc 805561 ggaggcatta acatttattc gccatcccct gaacaatttc ccgaattaaa agagggtatg 805621 gatgtcacgg tgacagggaa aatcacgtct taccaggggc tgaaagaaat cgttccaaac 805681 tcatcaggca tcaaaatcaa ccagtcaaat caatccctcc ccgcccccaa acacttaaca 805741 atcaatgaac ttattaacgg cagcctaggt gatcagtatg aaggacgcct tgtgaaacta 805801 accgcttttg tttcctcaat tccaagttct cctgccggcg gcggttacaa tgtaacaatg 805861 attgatgacg accatcatgc aatgacgctc cgggttatga atgaaacagg ggtgataaac 805921 gagcttgatg agggcaaatg gtatgaattt accggtgtgt taagcagata ccaaaccttt 805981 cagctgcttc cgcgaaaatc ggctgacctg aagctgcttg aagagcagcc cgcacctccg 806041 tctgcagagg gagaatatga agggattgtt gaccgggtag ttgacggcga taccattcat 806101 cttaaatctc cggtgcttgg aacgacaaaa atccggtttg taaatgtaga tgcacccgaa 806161 acatatcaca caccaaaaaa tgacgcagat gaaaatcaat taagatttgg caaaaaagca 806221 tctgactatc taaaaacggt tctgtccccg ggtgataaaa ttactgtcaa ggtcgggagt 806281 gaagccaagg acagctatgg cagattgctc ggacaagtca taaccgaatc aggttcaaac 806341 gtgaacttag agcttgtaaa aaacggctat gctccgacgt attttatttg gccggttgac 806401 aatgaagagg attatcagca atttcaggcc gcagtagccg ctgcaaaaaa agatcaaaaa 806461 ggaatttgga atgaaaacga tcccctcatg gaaatgccgt ttgaattcag agccagagag 806521 caagggaaag gcctgacaag atatgtgggg gactcgtcga ataaaacata tgtgcagcca 806581 gctgactgga agaagatagc tgtggaaaac agaattttct tcgcctcagc aagtgaagcg 806641 gagagcgcgg gatataaaaa aaggcaaacg gcacctcaag aacatgtgcc gcttagaatt 806701 ctcagcatga atgatttgca tggcaaaatc gatcagcaat atgagcttga tcttgatgga 806761 aatggaactg tagacggcac gtttggacgc atggattatg ccgccgcata tttaaaagaa 806821 aaaaaggctg aaaagaaaaa ctcgctgatt gtgcacgcgg gagatatgat cggcggaagc 806881 tctccagttt cctctcttct tcaggatgaa ccgactgtag aactgatgga ggacatcgga 806941 tttgatgtcg gaaccgtggg aaaccacgaa tttgatgaag gcacggatga acttctgagg 807001 atcttaaatg gcggtgatca tccgaaaggc acaagcggat atgatggaca gaactttccc 807061 cttgtatgtg ccaattgtaa aatgaaatca actggagagc cctttttgcc ggcttacgac 807121 atcattaatg tggagggcgt acccgttgct tttatcggag ttgtcacaca gtcggcagct 807181 ggcatggtta tgcctgaagg aataaaaaat atcgagttta cagatgaagc aacagcggtg 807241 aataaggcgg ccgaagagct caagaaaaaa ggcgtgaagg ccatcgcggt tctcgcacat 807301 atgtcagctg aacaaaacgg caacgccatt accggtgagt ctgctgatct tgcaaacaaa 807361 acagattctg aaattgacgt gatttttgcc gcgcataatc atcaggttgt taacggtgaa 807421 gtgaatggaa aactgattgt tcaagcgttt gaatatggaa aagcgatagg tgtcgttgat 807481 gtagagatcg ataaaacgac aaaagacatt gtcaaaaagt ccgcggaaat cgtatatgtt 807541 gatcaaagta aaatcgaacc ggatgtcagc gcgtcagcca ttttaaagaa atacgaaaca 807601 attgcggaac cgattatcag cgaggtagtc ggcgaagccg ctgttgatat ggaagggggg 807661 tattcaaatg acggcgatac acctcttgga aacctgattg cggatggtat gagagctgcc 807721 atgaaaacgg attttgccct tatgaatggc ggcggcatac gtgaagcgct gaagaagggt 807781 ccaattacgt ggggagatct ttacaatatt cagccgtttg gaaatgtgtt aacgaagctt 807841 gagattaaag gaaaagattt aagagagatt atcaatgcgc aaatctcgcc ggtttttggg 807901 cctgactaca gcatcagcgg gtttacgtat acgtgggata aagaaaccgg aaaagcagtt 807961 gatatgaaaa tggcagatgg caccgagatc cagcccgatg ccacatatac attgaccgtc 808021 aacaacttta tggcgacggc gacaggagcc aaatatcagc caatcggact gctgggaaaa 808081 aatccggtga cagggcctga ggatttggaa gcgacagttg agtacgtgaa gagttttgat 808141 gagccaattg cgtatacaaa agagggaaga attaagcttg ctgaagccag tgatattgaa 808201 gaccctgtaa cagaagaccc gataacggaa gagcctggag atgatccggg gacggaggat 808261 ccgattaaag aggatccaag gccaggtgaa gatttgcctg atataaaaga aactccggga 808321 acagcaccgg ttcatcagct tccgccttca gccatttcga gattcaatga aataccaatc 808381 aacaacacaa aaaccgctga tactgctaat agcatcagca cattgccgtt acaaaccgag 808441 actgcggaaa gcgggtctga tcatcagctt ccggatacgt cagcgggcta ctataacttt 808501 atggtaatcg gtgcggcggt gacattgtca ggaacttatc tatatgtcag aagaaaaagg 808561 agcgcctcca gaacgtgaaa aaagttattc cactattcat cattgctgcc ggcctagtga 808621 tcgcaggcta tggaggcttt aaattgatcg atacgaatac gaaaacggaa cagacattaa 808681 aagaagcaaa gctggcggct aaaaagccgc aggaagcttc ggggacgaaa aatagcacag 808741 atcaagcaaa gaacaaagca tcatttaagc ctgagaccgg ccaagcgagc ggcattttag 808801 aaataccgaa aatcaatgca gagcttccga tcgtggaggg caccgatgct gatgatttag 808861 aaaaaggtgt cgggcattac aaggacagct attatcctga tgaaaacgga caaattgtgc 808921 tgtcagggca tcgggatacc gtgtttcgcc ggacgggaga gctggaaaag ggggatcagc 808981 tccgtcttct cctgtcatat ggagaattca catatgaaat tgtaaaaaca aaaattgtcg 809041 ataaggatga cacatctatt atcacgctcc agcatgaaaa ggaagagctg attctgacga 809101 cctgctatcc gttttcatac gtcggaaatg ccccgaagcg ctatattata tatggaaaac 809161 gagtgactta aaaagccgag gcagtgcctg cggcttttct tcatgaaaaa tatgtgcggc 809221 aaaggttttt catatcagca gggaaagggg cttcagcaac tatgagctcg tctgttatcg 809281 ggtgaaccgc ttgtacttta ttggcgtgca gtgcctgcct gtttagcagc ttgctcccgc 809341 ctccgtaaag cgagtctcct gtcaacggat ggccgaggct cgccagatga acacggattt 809401 ggtgtgttct gcctgtttcc agctctaatt caacgagcga cagccgttct ttcgcattgc 809461 tggccattac cttgaaatga gtgacggctg tttgcccgcc tggtgaaacc cggcgtcttg 809521 tcgggtgtga gcggtctctg ccgatcggtg aattaattgt cccttttttc gtccgtagct 809581 taccttcagc gatagcggta tacgtacgct tcagcgtctt tttctctaac tgctggtcta 809641 agatggcgtg tgccaaacga tgcttggcaa aaacgatagc gccagatgta tcctgatcaa 809701 gacgatggac gtggcgcacc ttacatgttt cgccatttat ctgataatga tacgcgatca 809761 aattagccag tgtgccggtt tgcccatcct cattcggatg cgtcgcgatg ccagcgggtt 809821 tattgatgat gagcatatga ttgtcctcaa ataaaatatc aagctcgcca tactccggaa 809881 tgaccgaaga tgcttcactt tcctgaagat caatgaacac gcggtctccc ttttttacaa 809941 tcatattgtt taagacggat tcgtgattga cctttatctg ttgatgggac atccagtctt 810001 gtatcactgg tttagaagct ttgagcgctg ttttgagtac ggaaaacagc cattggccgt 810061 cctgtttttc attgatgagg atctcaagcc ctctgccttt ttggttcatg ttaaatggct 810121 ccttttcgaa gcggaaggct gctgtttctc ataggaaaca cttaccttag ctttcgcgtt 810181 tttttctgtg ctattcttga gtaagactta ggatattcga tggcaagaaa ggtgattgac 810241 gtgagaattg tgaacgcagc aactgcagaa caggagagct ttatcaagga gctgtctatg 810301 gagctgatcc atgatgtatt tcctctttat ttctccgaac tggacattca gcgctttaaa 810361 aagaaaggcg ttctgtcttt aaataaccat tattaccaag gaacattaaa agaagcattt 810421 caaattatgg cttgtctgca aatgatacat attatcctga ccaagccttc gccgcactct 810481 gatttgagtg atcaggcgat ttttgaaaaa aacagcaaga tgctgaatga ttttgggatt 810541 tattttccgt ttgctttttc tgactttcaa aagaagacta acaaagcctt tttcggtcaa 810601 agaaggctga tataatcatg cggcaagggc ttttctattt ttagaaaagc tctttttgta 810661 tcagagaaat catatcataa aacctttcct ctaactccct ttttaaacgg ctcgtgtctg 810721 aacatactaa tgattgaaag gggtgctgac aatgagttca gttaaagata caatgacaac 810781 gcaggtggca accgtttctc cgaatcaaac gattcaggaa gcggcttctc taatgaaaca 810841 gcataacgtc ggggcgatcc ccgttgtaga gcaaggtgtt ttaaaaggaa tgctgactga 810901 ccgtgacatt gcattaagaa ctacagctca gggccgtgat ggccagacac ccgtttcaga 810961 agtgatgtca acagaactcg tatcaggaaa ccctaatatg agtctggaag acgcgtcgca 811021 gctgatggcc cagcaccaaa tccgccgcct tcctattgta gatcaaaaca atctagtcgg 811081 gatcgttgcg cttggagacc tggcagtcaa tcagatgtcg aacgagtctg cgggatcagc 811141 gctgacaaac atttctcacc aaaacattca ttaataagaa agagcttgca gtgtgcaggc 811201 tctttcttca cataaaacct tactttttga aagcagactt gtttcggggt atagtgagtg 811261 tatacatatg tctcaattcg tactaaagga gttgtaccca gtgattaaag cgttaatttt 811321 tgattttgac gggcttattc tagatacaga aacacacgaa tatgaggttc ttcaggaaat 811381 atttgaagag cacggctcag tgctgccgct atctgtctgg ggaaaggtca tcggaactgc 811441 tgcgggtttc cggccttttg aatatttaga agagcagatc gggaaaaagc tgaaccatga 811501 agagctcaca caattgagaa gagagcggtt tgccaaacgc atggaatcag aaaaagcgag 811561 acctggtgtc gaagcgtatt tgaatgcggc aaaggattta ggcttaaaaa taggccttgc 811621 ctccagctct gattataaat gggtgtccgg ccatttgaag caaatcggcc tgtttgatga 811681 ttttgaagtt attcaaacgg cggatgatgt ggaagaggtg aagccgaatc ctgaactcta 811741 tttattggcg gcaaagaacc tgggggtatc gccagcggaa tgtctcgcgt ttgaggattc 811801 tgtcaatggt tcgattgctg cgaaacgtgc aggcatgaag tgtgtcattg tcccgaataa 811861 agtaacgggt accttgatgt ttgaagacta tgatcacagg cttgaatcaa tggcggagat 811921 ggagctcgcc ctattgcttg atcatctgaa ctcacaaaac tagaaaggag cgagtaggtt 811981 gtctgagaaa ttagatttga cccggtttga aaagaaaatg gttatccgca atatcgaaga 812041 gaaagacatc gacaagatta tcgatcttca aaaggactgc tttccaggaa tggagccttg 812101 gaagcgggag catttaatca gccatttgga gcattttccg gaaggacagt tttgtgcaga 812161 attcgaaggt gaaattatcg gttcgtgctc aagtctcctg attaactttg atgaatatga 812221 tgaccgccat acgtggcagg acattacaga tgacggttat atcaccaacc ataatcctga 812281 cggcttgaat atgtacggaa ttgaagtcat ggtgcacccg aaatacagac gaatgaagat 812341 cggccaccgt ttgtacgagg cgagaaagga cttagccaga cgcttaaacc tgaaaagcat 812401 catcataggc ggacggattc caaactatca caaatatgca gaggaaatga cagcgagaga 812461 gtatgttgaa caggtgacac gccaccaaat ttacgatccg gttctttctt ttcagctgat 812521 gaacggcttt acccttatgc gaattaaccc gaactatctc ccggatgata cagcttcgat 812581 caagtatgcg acgctgatgg aatggaataa tgtcgattat ctaccgcagc agacaaaacg 812641 ctattataaa tcggcgttcc ctgttagaat ttgtgtgatc caatacgaaa tgaagaaaat 812701 ttattccttt gaggaatttg cgaatcaagt agaatactat gtcgatgttg cttccgacgc 812761 aagatctgat tttgcggtgt tcccggaaat tttcacaacc cagctgatgt ccttccttga 812821 ggaacggtca ccgagcttgg cggtgcagag aattaccgag tatacagaag attacatcag 812881 cctgtttact gacttggctg tgaagtataa cgtcaacatt atcggcggat ctcatttcgt 812941 cgaagaggaa ggcaagatct ataatatcgc ttacctgttc agacgggacg gaacgatcga 813001 gaagcaatac aaactccata ttacgccgaa tgaacgcaaa tggtggggga tcagcgcagg 813061 agaccaagtt cgcgtgtttg atacggactg cgggaaaatc gcgatccaga tctgttatga 813121 cattgaattt cctgagcttg cccggattgc ggctgataaa ggagccaaaa tcatctttac 813181 gccattttgt acagaagacc gtcaaggcta tctgcgtgtc agatactgtt cgcaggctag 813241 agcggttgaa aatcaaattt atacggttat ctctggaacg gtcggaaacc ttccgcaaac 813301 ggaaaacatg gatatccaat acgcccagtc aggcatcttt gccccgtctg attttgaatt 813361 cgcccgagac ggcattgtcg gcgaaacaaa cccgaatatt gaaatggtcg tcatcggcga 813421 tgttgacctg gaaattctca gaagacagcg ccaaaacggt acagtgcgcc agctaaaaga 813481 cagacgacgt gatatttatc atattcaata taaaaaataa ttcccaaaaa acccgcctga 813541 attggcgggt ttttttaaac aaaagcggaa ttgtttaggt gctttcttta aaataaaagt 813601 aaattgtata gtggatgtgc cttatggagt ttctgtattt tcgccatttc ctatatcata 813661 cagaaaacgg ctaggcttca cattgctatt gcaatggctg tccaagttgt ttcgagtgcg 813721 acctttatca gtacgatgct gagcattgtc actttgcctg ttttgctttg gaagctgcat 813781 cctctttctt cttgagaaag gggatgtttt attatttacg cggtttattg actctgaccc 813841 ggtctggctt tatattgaag gcagggaaat catcaccaag acatcacata aagagaaggt 813901 ctgtttcaat tgaattggca ttatagggaa cgctaatgaa atggagatga tggggatgga 813961 aaacattcag caaaatcagg gattaaagca aaaagatgag caatttgtgt ggcatgccat 814021 gaagggagcg catcaagcgg acagcctgat agcccagaag gccgaagggg cctgggtaac 814081 cgacacagac ggacgccgct atttggatgc gatgtccggt ttgtggtgcg tcaacattgg 814141 ttacggcaga aaggagcttg cggaggctgc ctatgagcaa ctaaaggagc tgccttacta 814201 cccgttaacg caaagtcacg cacccgcaat tcaactggcg gaaaagctga atgaatggct 814261 tggcggcgat tatgttattt ttttttccaa cagcggatcg gaagcaaacg aaactgcttt 814321 taaaattgcc cgccagtacc atctgcaaaa cggcgaccac agccgttata aattcatctc 814381 aagatatcgg gcataccacg gcaatacatt gggagcgctc tcagctaccg gacaggcgca 814441 gcggaaatat aaatacgagc ctttgagcca agggttcctg catgcagctc cgccagatat 814501 ataccggaat cctgatgatg cagacacgct tgaaagcgca aatgaaatcg accgcatcat 814561 gacatgggaa ttaagcgaaa cgattgccgg ggtcattatg gagcccatca ttacaggcgg 814621 aggcatccta atgccgccgg acggatatat gaagaaggtg gaggacattt gccggcgcca 814681 cggagccctt ttgatttgcg atgaagtgat ctgcgggttt ggacggacag gtgagccgtt 814741 cgggtttatg cactacggtg tgaagcctga tatcattacg atggcaaagg gaatcacaag 814801 cgcgtatctg ccattgtcag cgactgctgt gaaacgggac attttcgaag cgtatcaggg 814861 ggaagctcct tatgaccgtt tccgccacgt gaacacgttc ggcggaagcc cggctgcctg 814921 tgctttggcg ttgaaaaacc tgcaaattat ggaggacgaa cagctgattc agcgatcccg 814981 tgatcttgga gcaaagcttt taggtgagct tcaagctctg agagaacacc cggcagtcgg 815041 ggatgttaga ggaaaagggc tgctgatcgg aatcgaactc gtcaaagaca aattgactaa 815101 agagccggct gatgccgcca aagtaaacca agtggttgcg gcgtgcaaag aaaaagggct 815161 gatcatcggc aaaaacggcg atacagtcgc cggctacaac aatgtcatcc agcttgcgcc 815221 gccattttgc ctgacagaag aggacctttc ctttatcgtg aaaacggtga aagaaagctt 815281 tcaaacgata taatataaaa gtgaattatt aaaggagcac atgatgagtt ttcacaacca 815341 gccgatctta ccggctattc gcaatatgaa gcaatttgat gagtttttga acagttcatt 815401 ctcttacggt gttattcttg atattcatct cggccagctg aagggcgtga tcaaagaagc 815461 gcaaaagcac ggaaagaaca tgatggtgca cgtcgatctc attcaaggga ttaagcatga 815521 cgaatacggt gcggaattta tatgtcagga tatcaagccc gctgggatta tttccacaag 815581 atcgaatgtg attgccaaag cgaagcagaa gaaaatttat gccattcagc gcctgttttt 815641 gcttgataca agcgcgatgg agaaaagcat ggagtttatc ggcaagcata agcctgactt 815701 catcgaagtg cttcccggca tcgttccgtc actcattcag gaaataaaag agaaaacagg 815761 gattcccatc tttgccgggg gtttcatccg tacggaagag gatgtagagc aggcattgaa 815821 agcgggggct gtagctgtca caacatctaa taccaaattg tggaaaaaat atgaaaactt 815881 tttgacggaa agtgattgac accgctttca tgcactgata caattgcact aggttaatac 815941 attgtgatgg agaactcgga gaccacagca gctctttacg gcaaatgttt atgcacccgt 816001 aaagcggttt gttgtggttt ttttattctc ttcttctcta tcatgctttt taatcgtgac 816061 tttaggagga atgtgctatg acagcatttt ggggagaagt catcggtacg atgctgctta 816121 tcatttttgg tgcaggtgtt tgtgcaggtg tcaatttaaa gaaatcgctt tcattccagt 816181 ctggctggat tgttgttgta tttggatggg gattgggtgt tgccatggcg gcatacgcgg 816241 ttggcggcat cagcggtgcc catttgaatc cggcgctaac gatagcgctt gcatttgtag 816301 gagattttcc ttggaaagag gttccggttt atattgcggc gcaaatgatc ggagcgatca 816361 tcggtgcggt gattatttat ctgcattacc tcccgcactg gaagtcaacg gatgatcccg 816421 ctgccaagct gggtgttttc tcaacagggc ccagcattcc gcatacattt gcaaacgttt 816481 taagcgaagt gattgggaca tttgtccttg tacttggaat cttggccata ggtgcaaatc 816541 aatttacaga aggacttaat cctttaatcg tcggtttcct cattgtagca atcggtattt 816601 ctctgggagg caccaccggc tatgctatca atcctgcacg tgacttaggt ccgcggatcg 816661 cccacgcttt tcttccgatt ccggggaagg gctcatcaaa ctggaaatac gcatgggttc 816721 cggtagtcgg cccgatttta ggcggatcat tcggcggtgt attttacaac gctgcattta 816781 aagggcacat cacaagcagc ttctggattg taagcgttat attggttgtg gtattgttag 816841 gactctatgt ttatacgaaa tcacattctg ctaaaacatt atcaaattct aaatatattt 816901 aatcaaaggg gagacatctt atggaaacgt acattttatc cttagatcag gggacgacaa 816961 gttcaagagc gattctgttt aataaagaag gcaaaattgt ccactctgct caaaaggaat 817021 ttacacaata cttcccgcat cctggctggg ttgagcataa tgccaatgaa atttggggct 817081 ctgtcctcgc ggttatcgcc tcagtcatct ctgaatcagg aatcagcgct tctcaaattg 817141 ccggcatcgg catcacgaac cagcgcgaga cgacggttgt gtgggataaa gatacaggaa 817201 gtcctgtcta taatgcaatc gtttggcagt ccagacagac gtccggcatt tgtgaggaac 817261 ttcgtgaaaa aggatataat gataaattca gagaaaaaac agggctttta atcgatcctt 817321 acttctccgg cacgaaggtg aagtggattt tagacaatgt ggaaggcgca agagaaaaag 817381 cggaaaaagg cgagctgctg tttggaacga ttgatacgtg gctcatttgg aaaatgtcag 817441 gcggaaaagc gcatgtgacc gattactcca atgcctcaag aacactgatg tttaatattt 817501 acgatttaaa atgggacgat gaactgctcg acattctagg cgtaccgaaa tccatgctcc 817561 ctgaagtgaa gccgtcctct catgtgtatg cggagactgt tgattatcac ttcttcggaa 817621 aaaatatccc gattgctgga gcggcaggcg accagcagtc cgcattgttc ggccaggcat 817681 gctttgaaga aggcatgggg aaaaacactt acggcacagg atgtttcatg ctgatgaata 817741 ccggggaaaa agcaattaag tccgaacatg ggcttttgac aacaatcgct tggggcattg 817801 acggaaaagt gaactatgcg ttagaaggga gcatttttgt cgcaggctct gccatccagt 817861 ggcttagaga cggtttgaga atgttccagg attcatcgct aagcgaatct tatgcagaaa 817921 aagtggattc aactgacggc gtgtatgttg ttccagcatt tgtcggactg ggaacgcctt 817981 actgggacag cgatgtgcgc ggttcggttt tcggcctgac aagagggaca acaaaagagc 818041 actttatccg tgcgacactg gagtcattgg cttatcagac caaagatgtg cttgacgcaa 818101 tggaagcaga ttcaaacatt tcattaaaga cgctccgtgt agacggagga gctgtaaaaa 818161 acaatttcct aatgcagttc caaggagacc tgttgaatgt tcctgtggag cgcccggaaa 818221 ttaatgaaac gactgcactt ggcgcggctt atttggcggg tatcgctgtg ggattctgga 818281 aggaccgttc tgaaatcgcg aaccagtgga atctggataa acggtttgag cctgaattgg 818341 aagaagaaaa acgaaatgag ctgtataaag gctggcaaaa agccgtgaaa gcagctatgg 818401 cttttaaata aagtaatact atggtataat ggttacaagt taataagaac ggtcctgaga 818461 tgaggagaga ccacagcacc aaagtgtaag catgcacttt ggctgttgtg gtctcttttt 818521 ctatttaccg tgacaacaag gaggaaacgt aatgatgaat catcaatttt caagtcttga 818581 aagagatcgc atgctgacag acatgacgaa aaaaacatat gacctattta ttatcggagg 818641 aggaattaca ggagccggaa cagctcttga cgcggcatca aggggaatga aggtcgcact 818701 aagcgaaatg caggactttg cggcgggaac atcaagccga tcaacgaagc tggtacatgg 818761 cggcttgcgc tatttaaaac aatttgaagt gaaaatggtc gctgaggtag gaaaagagcg 818821 ggcgattgtg tatgaaaacg gcccgcatgt cactacaccg gaatggatgc tgcttccgtt 818881 tcataaaggc ggcacattcg gttcatttac aacatctatt gggttaaggg tttatgactt 818941 ccttgcaggt gtgaaaaagt cagaacgaag aagcatgctt tcagcaaaag aaacgctgca 819001 aaaagagcct ttggtgaaaa aagacggctt aaaaggcggc gggtactatg tggaataccg 819061 cactgacgat gcgagactga ccatcgaagt catgaaggaa gcggttaaat tcggggcaga 819121 gcctgtgaat tactccaaag tgaaggagct tctttacgaa aaaggcaaag ccgtcggcgt 819181 attaattgaa gatgtgctga caaagaaaga atataaagtg tatgcgaaaa aaattgtcaa 819241 tgctacaggc ccttgggtcg atcagctcag agaaaaagac cattcgaaaa acggaaagca 819301 tttgcagcat acaaaaggca ttcaccttgt atttgaccag tctgtctttc cgctgaaaca 819361 ggctgtatat ttcgatacac ctgatggccg gatggtattt gcgattcctc gtgaaggcaa 819421 aacatacgtg ggaacaacag acactgttta caaagaggcg ctggagcatc cgcggatgac 819481 aacggaggat cgtgattatg tcatcaaatc aatcaattac atgttcccgg aactgaatat 819541 cactgcgaat gacatcgaat ccagctgggc ggggctgcgt ccgctgattc atgaagaagg 819601 caaagatcct tctgaaattt cacggaaaga cgagatttgg acatctgact caggcctgat 819661 caccattgcc ggcggaaaac tgactggata cagaaaaatg gcggagcaca tcgttgatct 819721 tgtccgtgat cgcttaaaag aagagggcga aaaggatttt ggaccatgta aaacgaaaaa 819781 catgccaatc tctggcgggc acgtcggcgg ttcgaaaaat cttatgtcct tcgttaccgc 819841 gaaaacaaaa gaaggaattg cagccggttt atcagaaaaa gacgcaaaac agcttgcgat 819901 cagatacggc tctaacgtag atcgcgtctt tgaccgggta gaagcgctga aagatgaggc 819961 cgcgaaacgc aacattccgg ttcatattct tgctgaggca gaatacagta tagaagaaga 820021 gatgactgca acccctgctg acttctttgt ccgcagaacg ggacgtttat tttttgatat 820081 caattgggta agaacatata aagatgccgt tattgatttt atgagcgagc gattccaatg 820141 ggatgagcag gcgaaaaaca aacatacaga aaacctcaac aagcttttac acgatgcggt 820201 cgtaccgctt gagcaataaa tcataacggg ctgtctgcag cccgttattt ctttttacgt 820261 gccgaaaggg ggagatctca ggttatcaag tgacagaggc acccgcttca tataaaataa 820321 tggcataagc tgatacatag gaggacgaat atgacttgga gaaagagcta tgaacgctgg 820381 aaacagacag aacatttaga tctggaatta aaagagcgcc ttattgaatt agagggagat 820441 gaacaggccc ttgaggactg tttctataaa gaccttgaat tcggtaccgg cggaatgcgc 820501 ggggaaatcg gcgccgggac aaatcggatg aatatttaca ctgtgcgcaa agcatcggcc 820561 gggtttgcgg catacatctc gaagcaaggt gaggaagcga aaaaacgggg cgttgtcatt 820621 gcttatgatt cccgccataa gtctccggag ttcgcgatgg aagcggcaaa aacacttgcg 820681 acacaaggca tccaaacata cgtgtttgat gagcttcgcc cgacgccaga gctgtcattc 820741 gctgttagac agctgaacgc ttatggtgga attgtggtaa cggcaagcca taacccgcct 820801 gaatataacg gctacaaagt atacggggat gatggcggcc agctgcctcc aaaggaagcg 820861 gacatcgtca ttgagcaggt aaacgcgatt gaaaatgagc tgacgatcac agtggacgaa 820921 gaaaataagt taaaagaaaa aggcttaatc aaaatcatcg gtgaagatat tgataaagtt 820981 tatacagaaa aactgacgtc catttctgta catcctgaat tatcggaaga agtagatgta 821041 aaggttgttt tcacaccgct gcatggaact gcaaataaac cggtcagacg cggtcttgaa 821101 gcactcggct acaaaaatgt aacggttgtc aaagaacagg aactgccgga ttcaaacttc 821161 tccactgtta catcgccgaa cccggaagag catgcggcat tcgaatatgc cattaagctt 821221 ggggaggagc agaatgcaga tattctcatc gcgacagatc ctgatgctga ccgcctcggc 821281 atcgcggtga aaaacgatca aggcaaatat acagtgctga caggaaacca aaccggagcg 821341 ttgctgcttc attacctgct ttctgaaaag aaaaaacaag gcatcctgcc tgataacggt 821401 gttgttctca aaacgatcgt cacaagcgaa atcggccgtg ctgtagcttc ttcattcggc 821461 cttgatacga ttgatacgct gacaggcttt aagtttatcg gtgaaaagat taaggaatac 821521 gaagcatcag gccagtatac cttccaattc ggttatgaag agagctacgg ttatttaatc 821581 ggggattttg cccgcgataa ggacgccatt caggctgcgc ttttggcagt tgaagtttgc 821641 gcgttctata aaaaacaggg aatgtcattg tatgaggcgc tcatcaatct ctttaacgaa 821701 tatggttttt atcgtgaagg gctgaaatcc ctgacgctga aaggcaaaca aggagcagag 821761 caaattgaag cgattcttgc ttccttcaga caaaatccgc cgcagaaaat ggcgggcaaa 821821 caggttgtca cagcagaaga ttacgctgta agcaaacgga cgcttctgac tgaaagcaaa 821881 gaagaagcca tcgacttgcc aaaatcaaat gtattgaaat acttcctgga agacgggtct 821941 tggttctgtc tccgtccttc tggaactgag ccgaaggtta aattttattt cgccgtaaaa 822001 gggtcatctt tggaagacag tgaaaagcga cttgccgtcc tttctgaaga tgtaatgaag 822061 acggtggatg aaattgttga gtcaacagca aaataattca agtatgagct gggtcattgt 822121 aaatgatccg gctttttctt tttctcatcc aaaagtctga aagaaaatca tcctacaagt 822181 gaagcaatga aatacaaaaa actggtataa tcttaaatac aagatcaatg ccggagtgag 822241 aaacgtgagc aaaacgagga tggaaaaatt aaaaacgctg aaaacgattg cggaaacctt 822301 aaatcaaggg cacgatatca aagcaacact ggatgaggtt ttaaaagagt tgctgagtct 822361 gacaaacctt caatccggat ggatttttct gatcgaagaa gatgggtctt atacgttagc 822421 ggccgacgct tatctgcccc cggctttaag ccgcaaggaa aaagtgctga tgtgcgaagg 822481 ggagtgttac tgcctgacga aattcaataa cggagggctt agaaaagctg caaatatcat 822541 gaactgcaaa cgcatcgaat cagcagaaaa cctgcattgt tttgacacag aagggattac 822601 gcatcatgca actgtgcctt tagaagacgg ggacagaaga ttcggattgt taaatgtagc 822661 ggcggccgga aaaaccatgt ttgatgagga agagctgcat ttactcgagt ctgtcgcctt 822721 tcagatcgga acggcaatcc agcgtatgag gctttctgaa tatcaacaaa aaaatgctct 822781 tttaatggag cgtaaccgcc tcgctcagga gcttcacgat tcagtcaatc aaatgctgtt 822841 ttccgtcagt ttaactgcca aagctgcgaa gacactaaca aaagatgaaa atttacagca 822901 gatgattgat ttcatccaaa acctatcaca ggacgcgctc gcagaaatga aagcgttaat 822961 ttggcagctt cgccccggag gattggaaaa agggctggct gaagccatta aaagctatgg 823021 tgcgctcatt ggattgaaga tcatttttac acaaaaaggc tgtcctgttc tgactgatga 823081 gcaggagcat atgctatggc gtgtcgtaca ggaagcttta aataactgca aaaagcatgc 823141 cggaacggat acggcgtatg ttagtctgac tgcttctttg tgccatgcgg agctggatat 823201 catcgatcat ggggcaggat ttcgctatga agcgcatgcc ggtctgcctt cacttggcat 823261 aaaaggtatg aaagagcgag cggaaaaagc cggagctaag ttttggattg agtcagcgct 823321 tggaactgga acaaagctgt ccatcaggct tccgctaaaa agccgaaaag gaggggcggt 823381 atgaaaattg tcattgctga tgatcatcat gttgtcagaa agggtctgcg ttttttcttt 823441 gccacccagg atgatattga agtcgtcgga gaagctgcaa ctggattaga agccctccgt 823501 gtcatcgaag agacaaagcc ggatcttgtg ctaatggatt tgtctatgcc cgagatggac 823561 ggcattcaag ccattaaaaa agcaatacag caatttccgg atacgaatat cattgtgctg 823621 acgagctact ctgatcagga gcacgtcatc cccgcgcttc aggcaggcgc gaaggcgtat 823681 caattaaagg atacggagcc cgaggaattg gtgaaaacac gacaagtgca tggtggcgaa 823741 tacaagcttt ctacagctat tatgccccat gtgctgacac atatgaaaaa tcagcacgac 823801 ccggaaaaag aaaaatacta tcaattaact agaagggaaa aagacgttct gactgaaata 823861 gcgaacggga aaagcaataa agaaatcgca gcagccttgt ttatttcaga aaaaacagta 823921 aaaacccatg tatcgaatct tttagcaaaa cttgaagtgg ccgatcgcac gcaagcagcg 823981 cttttcgcag tgaaatataa cctgaatgga gagatctcaa aatgaacatg ttagtcataa 824041 atggcacgcc aagaaaacat ggcagaacaa gaattgcagc atcctatatt gcagctctgt 824101 atcacacgga tttgattgat ctaagcgagt ttgtattgcc cgtttttaac ggtgaagcgg 824161 aacaatctga actgttgaaa gtacaggagc ttaagcaacg cgttacgaaa gcggatgcga 824221 ttgtattatt atcgcctgaa tatcacagcg gcatgagcgg cgctttaaaa aatgccttgg 824281 attttctaag cagcgaacaa ttcaaatata agcccgttgc attattggca gtagcgggag 824341 gcggaaaagg cggcatcaat gcgctgaaca atatgagaac tgtgatgcgg ggtgtctacg 824401 ccaatgtcat tccgaagcag ctggtgcttg atccggtgca tattgatgtt gaaaatgcta 824461 cagtggctga aaacattaag gaaagcataa aagagcttgt cgaagaactc agcatgttcg 824521 caaaagcagg aaatcccggc gtctaaacgc cgggatttgt ttatgtgaga agggctattt 824581 gatcttcata agtcagctct gtggcatgat caatatatcg gagaagggaa tacagcatct 824641 tttctaaaac ggcgtaatcc tgttcaaaat gatacgcatg cagaaaatgc tcaattcgtt 824701 ttgataacaa atcgtcctct gtacgcacca ttaaaattaa taaattatcc cattgagaac 824761 gatgggtgta ataaagcgct ttatcgtaat cggcataatc catgaatcgc ttctcctttc 824821 ttgggtgaga agttcatgat tagtttatgc cgcatcctct gttattgacg gggcaaaact 824881 tgccgtctgc gtcagtaaag gggtagcaat atgagggaga cataaaatca aaatgcctga 824941 atgaagatat cgcttttggt aaacctatga gggaatatat tctgggtaca ggagactgaa 825001 aaaatgaaat ccctgccgta taccatcgca cttctttttt gcggattgat tatcgtgtca 825061 atggctgcaa aaggtcattc aacggacaca gacgagtccg ttcaaaagtg ggaacagctt 825121 gcctggagca aaattcagga tgaatataag ggcgcttcat tttctgatta tgcttatatg 825181 gggcgtacag aggtgaatga tcagcagact aaagatgtct ttcgggtgac agtcagacag 825241 aaagatgaca ctttttctgt tcgggccgaa gtctattttc atccggtgac aaatcatatg 825301 atcagcatca acgtctttag gctctaataa aaaactgtac agccgttaag gccgcacagt 825361 ttctgttttt agaaatatcg ttttgcaccg agatagcgct gtttccagta agagttgttc 825421 atattggaaa tgacaactcc ggaatcgttg gcatttatga attccccgtt gcctaggtaa 825481 attccgacgt gggaagggcc ggctttatat gttgaaaaga aaacgaaatc tccgacagca 825541 ggctggctaa ctgatttcat tgtgttccaa tatcccgctg ccgttaatct agatacggat 825601 gtgactttgt tcagtacata gtaaatgaat ccgctgcagt caaacccgga cggtgtcgtg 825661 cctccccagc gatacggaac cccaagctgc gctttagcgg ccgaaatcat tgtgttaatc 825721 ttcgcactcg ttgagctggt ggtgtttgaa gaaccggatg aagacgatga tgaagctttt 825781 ccggaaatga ccagcttttg gccaacctgc aagacatccg tttttaaatt gtttttctca 825841 cgaatctgct gagctgttac attaaatttt tgagcaatca cccataagga atcaccgctt 825901 ttcaccgtgt atgtagtcgt cgtgccggag cttgcatttg acgaagaaga cgacgatgat 825961 gaagagcctg aagatgcttt acctgtcagc ttcaatactt gtccaacgta aagcacatct 826021 gatttcagat tgttgatatt tcggatttgc tgtacagtca ggttatagtt gtttgcgatt 826081 ttccaaagtg aatcaccgct tttaacggta tatttagttg ttgctgaagt ttggttcgat 826141 ttggatgaat tgtctttaga agacgtatca gagccgcttg attttgtttt caacacctga 826201 ttcacgtaaa tggtgtctga ttttaagttg ttcaagacct tcaattcagc gatggacata 826261 ttgactttgt ttgcaatttt ccaaagtgaa tctccaagct gcaccttata tgttcccgta 826321 gaagatgaag aacttgaact cttattagaa ctgctttttg aactggagct tgaactctta 826381 ttagagttgc tttttttact ggaactagag cttgaagaaa cagtaccgga cacctttaat 826441 ttctgcccag cacgaattaa atcgctgctt agtccgttta attttttcag ttcctgcacc 826501 gtcattttaa actcatttgc gatcagccaa agtgaatctc cgcttttcac tgtgtaaaca 826561 gaacttccgc tcttcttggt tgttgagctt gaagtagatg aagaagtgct ggatttgctg 826621 cctggaatag taagcgtctg gccgatcgac agaacagtag tcgaaagatg attggcggat 826681 gtgagggccg ccacacttgt gttataggtt tgggccagtt tccataaaga atctccgctt 826741 ttgaccttaa tcgttgctgc ttcagctggt gtcactacta aagttgtgcc gacaatcgca 826801 gatgctgtca gccctgctgc taatttcttt ttcatcttag ctctcctttt tcccccaatg 826861 attttgcatt tgctgtttct tttttatatc ggcacatttg tctcatcgtt ttgccttttt 826921 ataaaaatag ccaaattatc ttaacaataa gggggaaaaa gggcataaaa aaagaaggaa 826981 tcttaatcta ttccttcatt tttaaaagct tcatgatatc ttctttgttt ttgacgaggt 827041 cgcgcagtgt gtatttgtct aaaactgcga ggtaggctaa aagcgcttca ttcagcacat 827101 gttttaagcc gcaaaccggg gaaataacac agagattctt gttcgcatca aaacattcaa 827161 caatattaaa atcgtcctcc gtttttctga caacctcacc gatgttgatg tcttcagggt 827221 ccatgcctaa tcgtatgccg ccgccccgtc cgcgtatcgt ttctacgtag ccgagctggc 827281 cgagcctgta tatgactttc atgagatgat tttttgaaat agaatacgtt tcggcaatct 827341 gttttatatt tgaaagttct ccgggacgct ctgcagccag aaaaatcaac actcttaatg 827401 aataatctgt ataattggtt aacttcataa taagacctca gaataagaca ttttctatat 827461 cttatcataa tcgattgaaa aatgaaaaaa aaggaattaa aaaacatgca cccagctggg 827521 tgcatgtttt ttgcttacat gtcattcggc ggattttggt ttttacggtt tttttcgatt 827581 tctgtgtttt gcattttgcg ttcaaatgta gacagataac gtgatgcaaa atccttaccg 827641 ccaaggccga aggataaacc aaaagcaagt gcgaagccgc taagaacgat gatgaacgcg 827701 gaattgacga ttgtcgcagc gacacccagc tgatccaggg ccataaagaa agcaagtgcg 827761 ataatcgtat atttagcaat aggcgctaaa gacttgaatt cctgaccttt tatcatgctt 827821 gcgagcactt ttctcaccaa ttctcctgcg taaaggccga gtccgagaat gaatactgcg 827881 acaaggacat tcggcagata cgcgatgatg ccggtggcaa tttctacgag gaagtgcagc 827941 cgaacaattt gaagcgcctc agctgtaaag agcagaatga caatgatttg cgcaatcata 828001 ccgacaactt gagacaagga cagctttgca ggcgttccgg cttccatgcc cattttccct 828061 aagacagaat caaagcctgc gcgatggagc agtccggaca ccatggattt cacccatttt 828121 cctgcccaga tacccgctaa tacaagcacg atggcaatca tgatgttcgg aagcatgttt 828181 aaaatcgtat tcagcataga gacagctggt tttgaaatgc cggcgacatc cagctgatca 828241 agcgctgaaa tgaccaccgg aatcataatg agcacataag cgattgttcc gatgactgct 828301 gaaaggcttg tgtcttttaa gtaaattgat aaacccatac gtgccgcgaa tctttcggtg 828361 ccgatgcttg caaggaaatt cgtaatgata tcacggacaa ggcgggcaac aagccatccg 828421 attaatacga taagcgccgc tgcaaataat ttcggcagaa aagcgagcac gctttccatc 828481 atatttgtaa aaggacctga aatgccgctg attttcaaag aagataagac ccctggcaga 828541 aaaacaagca gcacgagata aaagacaatt tgtgaagcgg tattgacagc ctggtgaata 828601 tcttttcctt cagacaccaa attccacttg cgcagtttgt cactcgtgtt cagcttcatc 828661 ccgatttttt tgacaaggaa gctcaaaaca gaagctgcag cccatcctaa cagcagaatg 828721 agtccggctt tcagcacgct tgggatcgca gctgcaatcg ccgaaagcat actgacaaac 828781 ggcgatgcca ctgttgtcag gtgcaaaatg ttaaagaata aaataaagac gatgatcagt 828841 gcgataaaat aaacgacctt gcttatgact ttttccgagg aatagcgtga aggctttttc 828901 ccagcaaaga gcttgtcgtc gatttttgtt ttgctgagtc ctttgtatac cgctttttca 828961 atgattttag caatagccca gccgattaat aagacgagta aagcaatgat tacgtttggc 829021 agcttactga gataagaaga aaacacgtct gctacattca attggtatcg ctcctttttc 829081 gtagtatggt gtgtgtttac ccacttatcc aataagcaaa cagatgaatg tgccggggga 829141 attttttctt gcccgagtga gactatcatc ttttgtctgg cgggctcata cattatagat 829201 aagtccaagt aggggggatt cggttgaacg cggaggagaa gaagggatta cagcgggcaa 829261 ttgaggaaat taccgaaatt gcaaaaggat tcggccttga tttctacccg atgagatatg 829321 aaatctgccc ggctgaaatt atttatacat ttggcgcgta cgggatgccg acaagattca 829381 gccactggag cttcggcaag cagtttcaca agatgaagct gcactatgat ctagggttaa 829441 gtaagatcta tgagctggtc attaactcag atccatgcta cgcttttttg ctggacagca 829501 actcactgat ccaaaataaa ttgattgtcg cacacgttct tgctcattgc gatttcttca 829561 aaaacaactg ccgtttccaa aacacgaagc gcgatatggt ggaaagcatg gcggcaacag 829621 ctgaacggat aaaacactat gaacaggttc acgggataaa agaagtcgaa tcttttttag 829681 atgcaatcct ttcgattcag gagcatatcg atccgtcgtt ggtccgacca aagctccaat 829741 ggagtgtgga tgatgaggaa gaggagattg aagaggcagc cacgccttac gatgatctat 829801 ggtctttaga tgaaaagaaa ccgaaaaaac aagtgaaaaa atcgaaaaaa ccgttcccgc 829861 cgcggcctga aaaagatatc ctgcttttta tcgaggagca ttcccgggag ctggagccat 829921 ggcagcgtga tatattaacg atgatgagag aggaaatgct ttatttctgg cctcagctgg 829981 aaaccaagat tatgaatgag ggctgggctt cctattggca ccagagaatt atacgtgagc 830041 ttgatttaac ctctgatgaa gcgatcgagt tcgccaagct gaatgcaggt gtcgttcagc 830101 cgtccaaaac aggcattaat ccttattatt tagggctgaa aatatttgaa gacattgaaa 830161 agaggtacaa caacccgacg gaggaaatga agaaaatggg cgtgcagcct gactccggcc 830221 gggagaaaat gtttgaggtc agggagattg aatccgatat ctctttcatc cgcaattatt 830281 taaccaaaga attagtcatg cgcgaggatc tttatttgtt tcaaaaacag ggccgagatt 830341 ataaaatcat cgataaacag tggaagtcgg tgcgcgacca gctcgtaagc atgcgggtaa 830401 atggcggttt tccatatttg acagtaaacg acggcgatta tatgaaaaat aacgaactct 830461 atattaagca ttggtatgag ggcatagagt tggatttgaa atatttggag aaagtgcttc 830521 cttatttatt ccagctttgg ggaagaagcg tgcacattga gtctgtgctt gaggataagg 830581 aagtcatgtt ttcgtacgac ggaaaaggtg ttcaccgcag atatttataa aaaagaggat 830641 gcagcgttct gcatcctttt tattttccag tttttaaaat cttaaatatg atgtttgcct 830701 ggtccgtatt gttaatcaat ccgcggaatt tttcttttcc ggggccgtac gcgtataccg 830761 gtacttcttc gccggtatga tcggtactcg tccatccgct gttggagcgg gtattaaaaa 830821 tcttgatgat ggctttggag gcccctttgc ttttgtcagc ctgtgcagct gcttcaacgc 830881 ttttgatttc ttcagatgtg actttcagat tggcatagcg ggcgagcaca tctttaaccg 830941 gcttgccttc actgattttt ttggccatga attcaggtgt tttcttagcg gagagaatcg 831001 gttctgcgtg ccaattcttt tccccgtttg cgccaatggt aaagccgccg gttgtatggt 831061 cagcagttgc aatcacaagt gtatgtttgt cttttttcgc aaattcaatc gcggctttat 831121 aggcctgttc aaaatcttta acctcgctca tggctcctac tgtatcattg tcatgggccg 831181 cccagtcaat ctggctccct tcgaccatca agaaaaatcc ttttttattt tggttcaggc 831241 gatcaattgc tgaaaccgtc atgtctttga gagacggtgt tttactgtca cggtcgagcg 831301 ctttagcaag ccctccatct gcgaaaagcc cgagcacctg ctgatcttta ttttttttca 831361 atgcttgttt agttgtcaca tagctgtagc cggcttgttt gaattccttt gtcaagtttc 831421 tgtccttgcg gttaaaataa gattttccgc cgccgagcag cacgtctatt ttatgtttgc 831481 cttttatctt gtcatccata tagctgttgg cgatttggtc catgtttttc cgtgattcat 831541 tgtgggcgcc atatgcggct ggagtggcgt ggttaatttc agacgtggcg acaagccctg 831601 ttgacttgcc ttgctgtttg gcctcttcaa gtacagattt cacttttttt ccgtttttat 831661 cgacgccaat tgcattgtta tatgtcttaa cgcctgtcgc taatgctgtt ccggctgctg 831721 ctgaatctgt aatattatag tcagggtcat ccggatgcgt catcatcatg cctgtcaggt 831781 tccggtcaaa ttctgttaac ttcgggttat tcggtgtgtc accgttattt ttcatggaac 831841 ggtaggctct tatgtaaggc gtccccatgc cgtcgcctat catcacaatg acatttctga 831901 tctcagcttt gtcttgtttt ttggcgctgg ccttttctgt ttgctgaagc tcagctccgg 831961 caaagattcc agctgtaagg acagaaacag cggcgattgg cagaagtttt gatttcatat 832021 tttgaaacaa actcattttt ttcatgcctc ctttaatgta ttccgtttat catgttaggg 832081 aaactttgtt aaatgcggct gttgatcatg taaacaataa gtaaagcctt gtaaggaaat 832141 gaaaaaacgc ttttcgttat cttgccttat ttgatgtaaa gcattcattt ttcagaaaaa 832201 tctttacctc tctgtctttg catgatatgt ttgtttaaat aaaaaaactg cggataacca 832261 cagctctcct cgaatatact ttatcactca tttttccgat atatgagccg accccgaaag 832321 tttttcattt atttccttta tgttgaaaaa catcccataa aacatgacaa aagcactcgt 832381 tttttgtcac ctttgcaatg aaaatgaaat atttaatacc cttaaaaact tttttttaga 832441 acgaataatt aagaaatttg tcacatgaag tcaagactat ttctgatggg aatctatcct 832501 tataatagaa atcaataaga ttaatttaaa aaaagagata catatatata gagttaacat 832561 ttggggagga aaatatgaaa aagcaaatca ttacagctac gacagcagtt gttttaggat 832621 cgacgttatt tgcaggagcg gcatctgcac aaagcattaa ggtgaaaaaa ggcgacacgt 832681 tatgggatct ttcaagaaaa tacgacacaa cgatcagtaa aattaaatca gagaaccacc 832741 ttcgttcaga cattatttat gtgggacaaa ctttatcgat taacggcaaa tctacaagtt 832801 caaaaagcag cagttcttct tcctcttctt ctacatacaa agtaaagagc ggggacagcc 832861 tttggaaaat ttcaaaaaaa tacggcatga caatcaatga actgaagaag ctgaatggct 832921 taaaatcaga tttgcttcgt gttggacaag tcctgaaact gaaaggttca actagttcaa 832981 gcagctccag ctcatcaaaa gtgtcatcgt cttcaacttc tacttataaa gtgaagagcg 833041 gagacagcct ttctaaaatt gcgagcaaat acggcactac ggttagcaaa ttaaaaagct 833101 taaacggctt aaaatcagat gtaatctatg tcaaccaagt attgaaggtg aaaggaacaa 833161 gcacaagcag ctcaaaacct gcttcatctt catcgtcttc aagcagcaaa acgtcatcta 833221 catcacttaa tgtgagcaag ctggtttctg atgcaaaagc gttagtcgga acgccatata 833281 aatggggcgg aacgacaact tcaggctttg actgcagcgg attcatttgg tacgtactga 833341 ataaacaaac aagtgtgggc agaacaagca ctgcaggata ctggagttct atgaagagca 833401 ttgccagccc gtctgttggt gatttcgtct tcttcacaac atataaatcc ggcccttctc 833461 acatggggat ttacattgga aacaacagtt tcattcatgc aggatctgac ggcgtacaaa 833521 tcagcagcct gaacaacagc tactggaagc ctcgttacct cggtgcgaaa agattctaat 833581 ttttagagaa aacccgttca ttggaacggg tttttttcat tagacggagc acaggcgttt 833641 tggttgctcc taaaaatgaa aatgtgataa aaaatccaag aacttttttt ctttcttatt 833701 ttcataaagg gcaatcgcgt aagcgccggc atagggcagc tgtacagact gataaggaat 833761 tctgatcatc tgtttctctg ctaactcacg ctttactgta gataaaggca gaaatgaaac 833821 tccgagtcct tccttgataa accgtttcgt tatatgtgtt tgagtgacct tcattgttct 833881 cacaaatgga aatgtcattc tgacttgacg gagcaagtcg tcccagtaat caggatgatt 833941 gtgggtcaaa agcaggtatt gttcgagcac ctctttggca tcaatttcgt tgtcttctat 834001 gaaacgctta tcgggcgggg caacaaggac gacagggtct ttgtataagc agtggcagct 834061 taaagaagaa gactgtacct ttaaacagct tagtccgata tctgcttccc cggctttaat 834121 cagtgacgcg atttccgctg attcgaaaat cgtaaccgcc atttctgttt ccgtattcat 834181 tgctgtgtac cgcttcatga cagaaggaag cactgtatct gcaataagcg gagaaaccgc 834241 gagctgtaag gtttgagagt agccttgtct cactctgtga agctctgcca tgctgttttc 834301 ataatcatca agaagcctga gcgcatacgg caaatacgcc ctgccttcat cagtcagctg 834361 gatttgcctg cctttacgct cgaacagctt gcagctgatt tctttttcta attgcttgat 834421 atgtacggtc acagtaggct gagataagaa aagcgtttcc gccgtttttc ggaagttctc 834481 atattttgca gcggtcacaa aggtgtgaag ccatttgaaa tccatttcta ttctccctct 834541 gattaatatt tttaattaat tccctttaaa atattgatta ttttttaaat attatattta 834601 ctataataac agaaaaggat agggggaata caaatggtac attacggatt aaagggaatt 834661 acatgtgtag aaacatccat cagccatatt gatggtgaaa aagggcgtct gatttacaga 834721 ggacatcatg caaaagacat cgcactgaat cacagctttg aagaagcggc ttatttgatt 834781 ttatttggaa aactgccttc aactgaagaa ttgcaggtat ttaaagataa gctggctgcg 834841 gaacggaatc ttccggaaca tattgagcgc ttgattcaat cactgccaaa caacatggac 834901 gatatgtcgg tgctgagaac ggttgtttca gcattggggg aaaatacgta cacattccat 834961 ccgaaaacag aggaagcaat ccggctgatt gcaatcacgc cttctatcat tgcatacaga 835021 aaaagatgga cgcgcggtga acaagcaatt gcaccttctt cccagtacgg acatgtcgaa 835081 aactactatt atatgctcac aggtgaacag ccttcagagg caaaaaagaa agcgcttgaa 835141 acctatatga ttctggccac ggagcacggc atgaacgcat cgactttttc ggcacgagtc 835201 acgttatcta cagagagtga tttagtgtca gccgtcacgg ctgctctcgg tacgatgaaa 835261 ggtccgctgc acggaggtgc tccttctgcg gtgacaaaaa tgcttgaaga cattggagaa 835321 aaggaacatg ctgaagcata tctgaaagaa aaactcgaaa aaggagagcg cttgatggga 835381 ttcggccaca gggtgtacaa aacaaaagac ccgcgggcag aagctttgag acagaaagca 835441 gaagaggtgg ccggcaatga ccgtgatctt gatcttgcgc tgcatgtaga agcagaagcg 835501 attcgtttgc tagaaatcta caaaccggga cgaaagctgt acacaaatgt tgaattttac 835561 gcagctgcag tgatgagggc catcgatttt gacgatgaat tgtttactcc gaccttttca 835621 gcaagccgaa tggtagggtg gtgcgcccat gtactggaac aggcagaaaa caacatgatt 835681 ttccgcccgt cagcgcaata taccggtgcc attcccgagg aagttctttc ataacatatt 835741 ttggcgttta ttcatttctg tcgtgtggta acgttcagta tcaaccacat gtctaggagt 835801 gatgaatgtg aacccaatgg acagacaaac agaaggacaa gaaccgcagc atcaggacag 835861 acagccgggc attgagtcaa aaatgaatcc gctgccgctg tcagaggacg aggattatcg 835921 aggaagcgga aaactgaaag gaaaagttgc gatcattact ggaggcgaca gcggaatagg 835981 gagagcagca gctattgcct ttgctaaaga gggggctgat atctccattc tatacttaga 836041 cgagcattcg gacgcagagg aaacacgcaa acggatcgaa aaggagaatg tccgctgcct 836101 gcttatcccg ggagatgttg gggacgagaa ccattgtgaa caagctgtgc agcaaacagt 836161 ggaccatttt ggtaaactcg atatcttagt gaacaacgcc gctgaacagc atccccagga 836221 cagcattctc aatatttcaa cagaacagct ggaaaaaacc tttcgcacaa atattttttc 836281 catgtttcat atgacgaaga aagctttgcc tcacctgcaa gaggggtgtg ccattattaa 836341 tacgacatcg attaccgctt atgaagggga tacggcgtta attgattatt ccagcacaaa 836401 gggtgcgatt gtttccttta cgcgttccat ggcgaagtcg cttgcagata aaggcatcag 836461 agtgaatgcg gtggcgcccg gtccgatttg gacaccgctt attccggcga cattccctga 836521 ggaaaaagtg aaacagcacg gcttggatac cccaatggga agaccgggac agccggttga 836581 gcatgcaggc gcctatgttc tgctggcgtc tgacgaatct tcctatatga cagggcagac 836641 cattcatgtg aatggcggcc gttttatttc aacgtaatca acgaaaaacc agctcaagag 836701 ctggtttttt gtgtggtgaa aaatttcaaa ataaaaaatt tgtcgatttt tctaacaatt 836761 ttgttttcat ttttgcaatt ttatatataa tattgagtag gagaaaggaa tgattcgcga 836821 ccagtacaaa tatagtagaa aaaaaagaat aatgaccatt gttactcatg aattcagaaa 836881 attcaaataa aatatataaa aatagatgat cgggagttga aggggaatga aagggagcgt 836941 ttttaggaag aaaagcattc aggatttaat cgctgcgacg agcggggaaa agtctttaaa 837001 aagagaatta ggggcatttg atttaacgtt gcttggaatc ggcgccatta ttggcacagg 837061 gatttttgtt ctgacgggaa caggcgcagt cacggccggt cccgggctga cgatttcatt 837121 tgttgtggcg gcgttggctt gtttattcgc cgccctgtct tacgcggaat ttgcgtcaag 837181 tgtgcctgtt tcaggttcgg tgtatacatt cacttatgcg acattgggag agcttatggc 837241 ctttattatc gggtgggatt taattttaga atacatgctg gcggtaagtg cagtgtcggt 837301 cggctggtct ggttatttcc aatcgttttt atcagggctt ggcattcatc ttccggttgc 837361 tttaacagcg gcaccgggcg cagtgaaagg cacctttacc ctgtttaatc ttcctgcatt 837421 cgtcattgta atggcgatca catatttgct ttatttaggc atcaaagaat caaaaagagt 837481 caacaatatc atggttatct tgaagatact ggttgttctg ctgtttatcg cggtggcagc 837541 cgtttacgtg aagccgcaca actggcagcc gtttatgcca atgggctttg gcggcgtgtt 837601 cagtgcagcg gcgctcgtat tctttgcttt tatcggattt gacgctgtat cctctgctgc 837661 ggaagaaacg aaaaatcccg cgaaggatct gcctaaaggc attattttct ctttactggt 837721 ctgcacgatt ttatatgtca ccgtatcagc catcatgact ggggttatcc cgtttgctca 837781 atttgcgggt gtggatcatc cggtttctct tgttcttcaa agcgcagggc aaaattgggt 837841 ggcaggcatc attgatattg gcgccgtgtt gggaatgaca acagttatgc tcgtgatgct 837901 ttacgggcag acccgcgtca tgtttgccat gtcgcgtgac ggacttgtgc cgggttcact 837961 ttctaaagtg catccaaagc acaaaacacc ttatgtagcc acttggtttt tcggaacgat 838021 gtcggcgctt ctcggctcac ttgttccgct ggatgaactt gcaaagctgg tgaacatcgg 838081 gacgttgtcg gcatttgtcc tgatttctgt ggcagttatc gttttgagaa agaaacagcc 838141 tgatcttccg agagctttta aatgcccggg agttcccgtg atcccaggcc tggcgattct 838201 gttctgcctg ttcttgattt taaatctggg atgggtgacg attgtccgct tcctagtgtg 838261 gctgttaatc ggcttggtaa tctatttcct gtattcaaga aagcattcaa aattaaatca 838321 ataacctttt gataaagaga gcggccatac aggccgcctc ttttctgttc ttggcaaatg 838381 aatctataga aatgaagaca aaaataagag ataatatagg ctggaaagga agtgacgttt 838441 attgtctgag caaaaaccag tccaatgggc ttcgaaaatt ggtttcgtca tggcagcggc 838501 cggctcggct atcggcttgg gcgcgatttg gaagttccct tacgtagcgg ggaccaatgg 838561 gggaggagcc ttttttctta tcttcgtgtt atttaccatc ctcttaggct atccgctttt 838621 ggtgggggaa tttatttttg gaagacggaa ccagacgaat gccattgatg catataaaaa 838681 agaagcgccg cgatcagctt ggtttcttac ggggtggatc ggcgtagcgg cgtgtttctt 838741 agtgctgtcg ttttacagtg taatcggggg atggattttg ctgtatatcg tgaaaacagc 838801 gtcaggatca ctgtccgggc tttctcaagc acagtatggc gctctttttg cttctattat 838861 ccaaaatccg gtgcagacgc tcgcggctca gcttgtcttt atggcactga ctgtactcgt 838921 tgtcgcaaga ggggttcaaa aagggattga acgggtaagc gcggtgatga tgccgatttt 838981 gtttttattg tttattctgc tcgttcttcg gtctcttacg cttaatggtg caatggaagg 839041 cgtaaagttt ctgcttgtgc ctcatttcgg cgatctgact ccggaatcca tattattcgc 839101 gctgggacag gccttcttta cgttaacact gggggtttcg gtgatggtga cctacagctc 839161 ctatttgccg aaaacacaaa atatccctcg ttcggcagcc tccattgtct tgatgaatat 839221 cattgtgaca ctcttggcag gtttggctat ttttccggcg gttttctcat tcggttttca 839281 gccaaatgaa ggaccgacat tgctgtttac agtgcttccg gccgtttttg aacagcttcc 839341 gttcggcaca ttgtttttta tcggctttct cgttgcattt ttatttgcag ccttaacctc 839401 agcattttcg atggttgaaa ttatcgttgc cacaatcgga aaaggggacg aaaagaagag 839461 aaaaaaactg tcatggacga gcgggctttt gatctttttg gtcggaatcc catgctgctt 839521 gtcttatggc gttttgagtg atgtgcacct atttggcaaa acgttttttg atattgccga 839581 ttttaccgtc agcaatgttt tgatgccttc aggcgctctg ttaatttctc tatttatccc 839641 gctgaaaatt tcgaaaagcg aactcttggc tgaaatgcga aatggatcaa atgcaggtaa 839701 agcattcttt tacacatggt tttatttgct tcgttttatc gtgccgcttg ccattattat 839761 cgtgttctta aatttaatcg gaattttatc attttaaaaa acaggctccg tttccggggc 839821 ctgtttttta tttaataaga tgatatcaac ggtgcccatg ccgttttcag tttttggatg 839881 ccgagcctga tgtcctcttc tgacaaaccg ccataaccga ttaagacaga agtaaaaggc 839941 gtctgttcta tatatgaggg agacacggga tagagggtta caccgtggtc agcggctgct 840001 tgtattgctt cttcctcact tgctggaaac aaaaggcgca gcagaatgtg aagccccgag 840061 ttcttaccga gaatctcaac ggtgtttccc agttcagagc gaatggcttc taacaggaca 840121 gcgtgttttt ttcggtataa gcttctcatt ctatttatgt gtttttgcca ctctccggtt 840181 tcgatgaagt ctgccagtgc caattgcgag tgggcagaaa cggtctgctt cattaactga 840241 acattgtttt ggatcggttc catgagttca gggggcacaa tcatgaagct gagccgcaag 840301 gaaggcagaa gtgactttga aaaagtgccc agatatatga ctctgccatt cggatcaaga 840361 ccctgtaaag acggaatggg atggccgctg tagcgaaatt ctccatcgta atcatcttct 840421 ataatgaatg aatttgtttc tgccgcccat gccagcagct cctgtctgcg ggtaatcgtc 840481 ataatggtcc caatcggaaa ctgatgcgaa ggagtcgtat acatgagata aggattctga 840541 cggtagagct catccggcag gacgccttct gcatcagaac aaatcggagt gacatccatg 840601 tgatttgctt caaacatcct tcttgaacgg tgaaagcccg gttcttcaaa gccgattttt 840661 gtacctggct ttagcgaaag gcaaagattt tgcagaagca cggtggttcc tgcgccgatg 840721 ataatctggc cgggttcaca atttactccc cgagacagcc tgacgaatcg ggcaatcatg 840781 tgcctgagtt cgtattctcc ttgagggtcg ccagaggtgt gaaacgatcc ggaatagcga 840841 tcaagacttt ttactatgct ttttctccat gcgttaaagg gaaagagggt cggatcaacg 840901 ctgccctgat ggaagtcaat agcaggtgcg tttttttgat gtaatcccgg ctgtacagac 840961 tgctgaaaat ggtcaggagc tgtcgggaat cctggttcta cttccgccgc gaaccagccg 841021 attttcggct tgcttttgac atagccctca gcagttaatt gctcataagc tcgttctata 841081 gttgccgtgc tgacatcgag caagctggag agcctgcgtt ttgacggaag tcttgttccc 841141 tttgtgattc gcgcatgtga aatttcttgt ttaaaaaagg tataaagctg ttcatacagc 841201 ggtgttttgc tctttttatc aagaaacggc gtaatatcca tctcatgtct cctttgtagc 841261 tggcatggtc attttttctg atattggcta tttggcaaat gccatttatt agctatgatc 841321 attgtaacga aaggaaaggg gattgagaag atgatccata tgaaacaatt aacctcgaaa 841381 gaagaatggg ctgagtcgta tccgattatg agtgaattga gaacagaact ggatatagag 841441 acgtatttac aaaggcttga agcctgtgtg cagaaagaat cgtatatgct gtttgcctta 841501 tatgaaaata cagcaatcag agcgctgtgc ggggctctgc cgagagtttc cattcataaa 841561 ggagagcact tgtggattgc ggatcttgtt acaacggcac cttgccgatc aaagggatac 841621 ggcaaaatgc ttttggatta tgcctcagac tgggcgagaa aagccggact cggttttgtc 841681 agtctttcat ctggccttca gcgtaaagac gcacatcgat tttatacaga taaaatgggt 841741 tttactatag aaagttattt gttccgaaaa ccggtataac gaaaaaagac gcctgaaaag 841801 gcgtcttttt taaaagccaa actgtaaatt cgtatctaca gatacaatgg tatacacaca 841861 aataatcaca aagagattaa ggatgacgcc gagcaggcct ggacctgtgc gccctctctt 841921 gatgaagagt tcaacaacgc cgaacggaac ggcagccatg gcgaacggaa gcatttgata 841981 ggaataaaac gtgacgttgc tgataatggc caaattcagc aacagcaggg acagaaccgc 842041 tgtcccgaca gagatccagc cgaatacatt gtgttcttta aaaattctta ccagttccat 842101 aattccacct cgccgacatt cgctgatttt acagatttat ttttcagcat gcgctggatt 842161 tccttggttg gccctgtaac gaccgaaccg tatacattga caccgttttt ctctacataa 842221 tctaatcggt tatctacatt caggtctttc cgttttgaaa tgacctgagc ccatttttcg 842281 tgtttggaca tgaatttcag ggcgttgata aactgatcgc cattcgactt gccttttgta 842341 ttaagggcgg ccaagaactt tgaatccttt ccaggatagc caagaggttc tgtggaagct 842401 gtcttatttg tgtttttctc tgtttcgatt gcgttccaca aaaagctcac atcatagcct 842461 ttgaatttgt tatacacgtc ttttgtcgga tatgcacggt catatgaaag gtagacctct 842521 gataccgttc cttcaggcaa tgtgcttaac gttttttctg cttttgcggt cgtttgttca 842581 gacttgtttg aaggatgtgt aaagtaatgg ccggttttat tcacttctaa gtcatagtag 842641 tttactgccg gcgcttttac tttgttataa aacatttcaa cccgttcatt ccctacggca 842701 gccgtcttcg tgccaatctg cttttgcagc gggaattccg tattcattcc aaatagcttc 842761 acttggcttt tcagtccgga agtatcaaca agaacattcg gcatggtcag ggctacagtg 842821 actgcggcag tttccataaa ctcattgccg gtgctgtgtt ttccacccat tccgtaatag 842881 aggtagcttc ccagcgtaca aagcggcaaa atcatcaatg tcgaaatgac ggcaagcaca 842941 gaaattcgca aataagactt gcgtttgccg taggctaaaa tcgctttttg tttttcagga 843001 ctgatgctga gatcccaatc gttatcgtcc tctagttcgc tgtcaatcag ttcctgatat 843061 acttcaagct tctcgagttc ttcctcaaat gcagtcattt cctggtcgct catttcccca 843121 tttttatatt gatcaaaacg ctttttaaat tcttcattca tcattaacac ctctattata 843181 aagtgctttc agccgctgtc tggcacgaaa taaaacactt ttaaaattcg cctctgaaat 843241 attcataata tgggatgctt ctttgtagtt taactctttt aaataatata gcgttaaggc 843301 ctcccgataa ttatcgggga gctcggacat ataaccagtc agcacttcct ttatctctac 843361 ctgatgggca ggactttgaa cagcattttg aaagaggctt ccgattaagt catcagaaat 843421 ggttacttct ttcttatgct ttctgacgta atcaatgaag gcgtttcgcg ccacttgaaa 843481 aagccagggc tttactttgc tgtgatcata ggagtgaatg tgtatgtatg cccgcataaa 843541 ggtttcctgc agtaagtctt cagcaagatg cttgtctttt gtcatggaga gcaggaacct 843601 gtaaacatca ttcatgtaca tttggtaaat ttcatcgatc gtcactgcct tttctcccct 843661 ctatgttata cacgcataag aaaggtttaa agttgcacat tacatgcaaa cggctttttt 843721 atacctaatc aaacaccatt actatatagt acccaaaaat ggccgcaaaa gatagtgcgg 843781 agaaaggttt aacatttttt ccagagggga aaagatagtg aaaaagtgaa ggagtggcac 843841 aatggaatat accagtatag cagatacagg aatagaagcc tccagaatcg gcctcggcac 843901 atgggccatt ggcggaacga tgtggggagg cactgacgaa aaaacatcga ttgaaacaat 843961 ccgcgccgct cttgatcagg ggattacact gattgacacc gcaccggctt acggcttcgg 844021 gcagtccgag gaaattgtcg gaaaggcaat caaagagtac ggcaaaagag accaggtgat 844081 tctcgcaacg aaaacggctc tggactggaa gaacaaccag ctgttccgcc atgcgaacag 844141 agcgagaatt gtagaggaag ttgagaattc tttgaagcgg cttcaaacag actatattga 844201 tctttatcag gtgcattggc ccgatccgct tgtgccaatt gaagaaacgg ctgaagtcat 844261 gaaggaatta tatgatgcgg gaaaaatccg ggcgattggc gtcagcaatt tttcaattga 844321 gcaaatggat acatttcgcg ccgtcgcacc tctccatacg attcagcctc catataatct 844381 gtttgaaaga gagatggaag agagtgtcct tccttatgcg aaagataaca agataacaac 844441 attattatac ggcagtttat gcagagggct gttaacaggc aaaatgactg aagaatatac 844501 atttgagggc gatgatctgc gtaatcacga tccaaaattc cagaagcccc gctttaaaga 844561 gtatctttct gctgtgaatc aattggataa gctggcgaag acacgttatg gaaaatcagt 844621 gattcacttg gctgtcagat ggatcttaga tcagccggga gcggatatcg ctctttgggg 844681 agcaagaaag cctgggcagc ttgaggccct atctgagatt acaggctgga cgctgaacag 844741 tgaagatcag aaagatatca atactatatt ggaaaatacg atatcagacc ctgtcggacc 844801 ggagtttatg gccccgccga ccagagagga aatataacaa aagctgaggg cgaatcctca 844861 gctttttggc gtttaaacga gagaaatctt aaaaattagt accaggtaat aaaaaatatt 844921 gttataatag atgacagaaa gaatcattga ttacgacaaa ggaagtgcga tatgtataag 844981 ttttgtgcaa atgctttaaa agttattctt tctcttcgcg gaggagtgaa ggtgtataac 845041 aaagaaaacc ttccggccga ttcaggtttt gtcatcgcgt gtacacattc cggctgggtt 845101 gatgtgatta cactcggagt cgggattctt ccttatcaaa tacactacat ggcgaaaaaa 845161 gagctttttc aaaataaatg gatcggttcg tttctgaaga aaattcatgc ctttccggta 845221 gatcgggaaa atcccgggcc aagcagtatt aaaacgccga ttaagctgct gaaagaagga 845281 gagatcgtcg gtatcttccc aagcggaaca agaacctctg aggatgtgcc tttgaaaaga 845341 ggtgcggtga cgattgcgca aatggggaaa gcgccgcttg tccccgctgc atatcagggc 845401 ccttcaagcg gaaaagaatt attcaaaaaa ggaaaaatga agctgattat cggtgagcct 845461 cttcaccagg ctgattttgc ccacctgcct tcaaaggaaa gacttgcagc aatgacagag 845521 gctttgaatc agcggattaa agaactagag aataaacttg atcagctata aggcgttctg 845581 agagattgtc ctgaaactgt gaaaataaga aaagcaccct atacaaggtg cttttcttat 845641 tatgcttcct gctggttagc tgtctccaga agttcttctt cttgaagctt tttcacttca 845701 atatatgcga cgtggtggcc gtcaatttca ttaatgatga attcgcagcc ctcttcgatg 845761 atggaatcat ctttttcaac atcgtatttt tgagtaagga accagccgcc gattgtatcg 845821 acttcttcgt tctctaaatg gatgcctagc aggtcgttta cttggtcaat taacactttt 845881 ccgtcaagaa tataatggcc ttcgccgatt ttgcggattt cgctaatttc atcaatatca 845941 aattcgtcgc ggatttcacc gacaatttcc tcaatgatgt cctcaaccgt cacaagcccg 846001 gcagtaccgc cgtattcatc agacaaaatg gccatgtgga ccctctcttt ttgcattttg 846061 acaagcaggt cttggatcgg cgcagattca atgacatgaa tgatagggtt gacgaattga 846121 gaaatggtgg aatcaacaga tacctcaccg ctgatgcagg cggtcagcac ttctttaatg 846181 ttaataaccc cgataatgtt atctttatcg ccctcttcca cagggtagcg ggtatatttt 846241 tcaatctgaa tgatgtccat catttcagaa atcttgatat catgcggaag gctgacaatt 846301 tcggtccgcg gaatcataat ttctttcgcg agcctgtcgt caaattcaaa gattttattc 846361 acatatttaa actctgattg gttgatttca ccgcttttat agctttcaga caaaatgatt 846421 cgcagctctt cttctgagtg agccagttcg ttttctgaaa cggtctccag gccaaatgct 846481 ttggtcaata accgtgcgga attgttcaaa agccaaatga atgggaacgc gatgcggtaa 846541 aaccaaatca gcggtttcgc aaacagcata gacactgctt ccgccttttg gatagcgact 846601 gttttaggtg caagttctcc gacaacaacg tgtaagaacg tgataatggc atacgcaaaa 846661 ataaacgata tgacatgtga aagggaacct ggaacgttca tttggacgaa aagcgggtga 846721 agcagccttt cgatcgttga ttcacctaaa acccctaatc cgatggaagt caatgtaatt 846781 ccgagctgac acgcagataa atattcatca agatgcgtgg tcactttttt tacggctatt 846841 gctgctttat ttccttccgc gatcagctga tcgatccgtg agcctctgat tctgataatg 846901 gcaaactcag atgccacgaa aaatgccgtc agggcgatta aaacagcaac taaaatcaaa 846961 ttcactatgt ccaattagaa ccttcactct agcaatgaga atgaaggtaa cacctcctgt 847021 tagataaaat ggttttaact taacagcagc ataaatgatt ggaacacggc gagcttttca 847081 ggcgggagtt tgcttttcag cttgtcacga tcctcgggct tcagccgttc aaaccgatgc 847141 aagattccgg agatgttttg attcatatga tcaatttcta atgccagatt tccaatttca 847201 tcatcaagtt tagctgaaga gggaaactgg ttctccagtc gatctttaat atcggacagg 847261 gccaatcgct gcttcttgca atctacaata aatataagtc gtttgagtgc attttcgtcg 847321 tagtaacggt aatttgaaca ggatctggcc ggcgtaagca gaccgagatt cgtataataa 847381 tcaactgtcc gtttcgttac tccggcgagt gccgctagtt cactgatgcg ataagtctca 847441 gccccatcta tatccctccc aaccatcacg ttatagttat gagaatagtt taatatatga 847501 acggtgtctt gcacaagttt attgtttttt ttagaccgga attggaagtt gtggaattca 847561 tcatctgatt gaagtaacat aggaagatag aattttcaaa tttttatatg cggaagggac 847621 agatgaaatt ggctgggtta tcccgggaag ttgaagaaaa cttaaataaa ggatcatgga 847681 ttcgcaagct gtttgatgaa ggtgcaaggc tgaagaagga gttcggggaa gaccaggtat 847741 ttgatttttc actcggcaac ccgattgttg aaccgcctga agcttttaag agagcgttaa 847801 tagaggaagc tgaaaaaggc agccacggat acatacaaaa ccaagggctt cttgcagcga 847861 gagaaaaagt cgcgcaattt ctgggctcgc gttttgaagc tgatttctca gcggagcgca 847921 tcgtcatgac ggtgggcgcg ggaggcgctt tgaatgttgc gttaaaaagc atcgtaaacc 847981 ctggggaaga ggtcattatt cttgcacctt attttgccga atataagttg tatattgaga 848041 actacggggg aaaagccgtc agctgcccgt tgacaagccg gtttgagatc gacattgaag 848101 cggtaaggca atcgatcact ccacagacga aagggctgat tctcaataca ccgcataacc 848161 ccacaggcac tgttctcagc cagaaaaata tagacgattt aggcgcttta ttaaaagaaa 848221 tagaagagaa gagcggccag acgatttatg tgctgtttga tgaaccgtac agtcaattaa 848281 tctatgatga agagctggca aatccgtttc aatcgtacca tcgtgtgata ttggccagct 848341 cattcagtaa agatctcggc atagccggag agcggctcgg gtatatcgga ttggacagcc 848401 gaatgccgga tgcggacctt ttgatcaacg cttttgtgta ttgtaatcga acgcttggat 848461 ttgtgaatgc ccctgtcatg atgcagcggg ctgtggcacg aatggatgat ttaagagtag 848521 acgcgagcgc ttataaagag cgccgggatt taatggtaga cattttaaaa gaagccggtt 848581 ttgaatttga aatgccaaag ggaggtttct ttgtttttcc gaaatcgccg attgaagatg 848641 aagttgcatt ttgcgtgcat gccgcccaaa aatacaaatt attaattgtg ccgagcagcg 848701 gttttggaat gagcgggcat ttccgattat ccttcagtgt gccgatcgag cagattaaaa 848761 actcacggga cattttcatt tctttatata aagattttgc ttaagaaggc aaagaaaaga 848821 aaacagtttt caaggctgtt ttctttttat atccgcaaaa tccttcctct tccaatccag 848881 acaggcgcag aattgacaag caggcatgca gttaaggctt tcttcatgat aaaagtctaa 848941 aaattaaaaa tcatttttgg aatgagttgt gttacaataa aatatacaat ttataatcaa 849001 actttgactt ttggaggtgg tatgatgggg ccctctgctt aggcaacaat acaccgcgta 849061 cctcaatgtt aaggaaaaat gattatatca ggaggtgact ccttatcctt tgttgagagg 849121 atagggttaa atggacgata ttgacagtct gattttaatt ggcgtgctca ttgctttaac 849181 cgcgtttttc gttgcaagcg agtttgcgat tgttagagtg aggagatcca gaatagatca 849241 gcttatcaca gaaggaaaca aacgggcgat actcgcaagg cgtgtcatta cagatttgga 849301 tgaatattta tccgcatccc agctaggcat tacattgaca tcaatcgggc ttggcgtact 849361 gggtgagccg gcctttgaac ggctgctgca tccactgttt gaaccgctcg gcttgccgga 849421 ctcggtttca catgcagtct cttttgcagt cgcgtacggc ttgatcacgt tcctgcacgt 849481 tgttgtaggt gaactggccc cgaaaacggt cgcgattcaa aaggcagaac agctgacttt 849541 actgatagcg ggccctttgc gtttattcta tttgctcctg tttccgttta tttggatcct 849601 caatggatcg gcgcggcttt tatgcgggat gttcggtttg aagcctgcgt cagaacatga 849661 tggttcccat tctgaggaag aactcaggat gctgttatct gagagtttaa aaaacggaga 849721 gattaatccg tctgaatata aatatgtgaa taagattttt gaatttgata atcggatcgc 849781 caaagaaatt atgataccgc ggaaggaaat ggctgctgtg tcaactgaga tgacgatggc 849841 cgagatgctt gaagtcatgc tgaaggaaaa atacacgcgc tggccagtca cagatggaga 849901 caaagacagt gtgctcggtt tggtcaatac gaagcatttg ttttctgatt tgctgtttat 849961 gacagaagaa gaacgaatga agatgacgat ccatccgtat gtgaggccgg tcatcgaagt 850021 gattgaaacg atcccggttc atgacttgct gattaaaatg cagcgcgagc gcattcatat 850081 ggctatattg tcggatgaat acggaggaac ctcgggactt gtgacgacag aggatattct 850141 tgaggaaatt gtcggagaga tccgagatga atttgatgaa gatgaacagc cgctgatcca 850201 aaagcttggc gacggccatt atgtgatgga tggaaaggtt cggatcgatc aggtgaacag 850261 ccttcttggc gcatcgattc aagaagacgt cgatacgatc ggcgggctga tattaaaaga 850321 aaacatcgat attgaggctg gtgaatccat tcgcatcggt tcatatacga taaaggtgct 850381 gaagatggac ggccgattaa tcaagcaaat cgatataaaa gaagaagccg gcaacacaac 850441 cgggattacg gcgcaccaca agctgccgct gcccgagcct gtgatgctga acagtgcaac 850501 cttgagcgag aaataagctc aaggtttttt tatattgtga ttgtccagcc gcaccaaaat 850561 gcaaaaagcg acccgcaaag tgtcaggacg atgtacaaga tgctttcttt tacacgtttg 850621 gccataagga gttgaatagt ttcaacgctg aatgtggaaa aggtcgtaaa ggcgccaaaa 850681 aaccccgtgc caatgataag cgagaccgaa gcatttgcaa cgtgaagtcc tgtaaatatt 850741 ccgagcccga gagctccgag aatattgact gtcagtatgc caatgggcag gctgagacct 850801 ttggttttgg cggttatgac attgccaagc cagaagcgaa gcattgcgcc aagtccgccc 850861 cctatgaaaa tacccgctag tgtcattttt cctgcagccc ctttctttgc tgaatgcctg 850921 ctatgcgccg tcccacaaaa acaccaatca gtgcaaatat gatccctgat atcaatgagg 850981 ctgccacata taaaagagcc aatgagggtt gtccttgcaa aagcatcact gtttccttag 851041 aaaacgtgga cattgttgtg aagcctccgc aaaagccggt gcctaaaaaa gccgacagca 851101 gaggccgttt tgccccgatc ataaaaaatc cggtcaaaat gcctaataga aggctgcctg 851161 ccgcattttc cagccaggtt gccgccggga actgaccggt gtgtatccat aagtttaatc 851221 cgtatcggag gcaggcgcca agcgcgcctc cgataaaaac cgcgctatat attttcatgt 851281 ttgccatcct ttatgatgaa atccgggtaa tctgtaacga tgccgtccac gcccatggct 851341 tgtaattttg ccgctgtctt ttgattgttg acagtccatg caaatatgtt taagccattt 851401 ttattgatgg agccgatcat cagacggtta agccgtgtgt gttttatatt gacatagttt 851461 gcaaaagagc ggaaggcctt catctgattt ctggacagca tgccaaagtt gggccttgta 851521 atgaccgctg tcggaatcga aggataaagc tcgcggaacc tttggacgga gcggaactga 851581 aaggattgaa caatattatt gatagaaaaa gaaaattgcc ctaatagctg tcccacctct 851641 tcttcaattc cgacttgaga cggatggcct tttagttcaa ttaaaaggcc gatttttttg 851701 tggtagcgct tgagcaccgc ttccagggtt ggaatacgct ctccttgaaa agcgggaccg 851761 taccagcttc ctgcatcgag tttttgcaat tcctccaagg taaaatcctt aacaaagccc 851821 gatccgtttg ttgttcggtc aaccctgtca tcgtgtatca caacaatctg cctgtctttt 851881 gtaagctgga catccagttc gatcatatct gcattcattt tcaccgcaag gtcaaatgcg 851941 gcaatcgtat tttccggagc gtagccggat gctccgcgat gggcaatgat gtacaagcta 852001 agtcagctcc tcgtatgggc atttctgtta ttgtatcaaa tccatatatg caccgcgata 852061 caaactggtg aattttttct gccatatcgg aatggtccgg gctgaggaat gcgtataact 852121 aaaaaaagac actcagcgta tcagaacaca tttcgtcaga aaattaggtc tttcgacatg 852181 ttcacaacaa aatatgatcc tttataatag caaaaaagga ggcgagatca tgggaaaagg 852241 gagaatcaga gtggaggaaa gaattaaagc cgaaacggat gctgaaatgc aaaaagcaac 852301 tctccttgat cagacacaaa cgaaaaaagg taagtgactg tccctattga atctggctga 852361 tagatgaatt gagaaatgac cccggcgttt cgccggggtt ttgtgctgca taagacattt 852421 aaatgaacat ccttacgaat attttagtat aataaacaat tgattgggat agaggggaga 852481 cagtcatgcc ggattatctg cagcagtatt ttacgcttga taacatcata caaatcggca 852541 tcagcttggc gattttgctg gtgtttctta tacttagaaa attattcaca agatattttt 852601 ttaacctgct ttttaatttg acaaaccggc cgaaaacaga aatttttaaa caggtggttc 852661 tggcgtttga taagccggcc agatggtttt ttgttgccct tgggctgttt ttagcgatcc 852721 ggtattcacc gtttttagat gagcaaatgc cggtcatcag caaaatatac cgctcactga 852781 ttgtggcgct cttgtgttgg ggtctttgta atttgaccgc aacatcgtcg tttatcttcc 852841 ataaggtgaa ccagcgcttc gagcttgaca tggatgacat tctggccccg tttttatcca 852901 aattgctccg ttttgtgatc attgcgctca gtgtcagtgt gatcgctcag gaattcaatt 852961 atgatgtcaa cggatttgta gcgggccttg gtcttggcgg actggctttt gcgcttgccg 853021 cgaaggatac catcagcaac ttcttcggcg gtattatcat tattactgaa aagccgttta 853081 caattggtga ctgggtggag acgtcgacag taacaggatc agtcgaggat attaccttta 853141 ggagcacgag attcagaaca gcacaggggg cgcttgtaac ggtgccgaac tctacgctgt 853201 cgatggaagc gatcacgaac tggacaagaa tgaccaaacg ccagattacg ttttccatcc 853261 atgtgtccta cgctacgccg attgagaacc ttgaacgctc cattcattct ctcagaacaa 853321 tgctcttaga gcatgagggc gttgataatg aaataatcat ggtcaacttt gatacgtttg 853381 ccgacagcta ctacaattta ttttttaact tctatacaaa aacgacggtt tgggctgaaa 853441 accttaatat tagagaggat atcaactata aaattattga gattttaggt gcagaaggcg 853501 ttcagtttgc atatcccggc caaatggttg ttgtcaagca aaagcacgaa agcgaccaat 853561 tccaggtgaa tctaaataaa gaggaaaagg aacgggctta aaagagagac ttcgtctgac 853621 agaggcggag tctttttcat ggtaaaataa gagaaaaagg cggtgttgag ttggaaacat 853681 tcaaaagtat tctacatgaa gcacagagaa ttgttgtgct gaccggagcg ggaatgagca 853741 cagaatcagg gatccccgac tttcgttcag cagggggcat ttggacggag gatgcctcaa 853801 gaatggaagc gatgagcctt gattattttt taagttatcc gcgtctgttt tggcccaaat 853861 tcaaagaatt gttccagatg aaaatgagcg gcagctttga accgaatgaa ggccatttgc 853921 ttttagctga gctggagaag caagggaagc aggtcgatat tttcacgcaa aacattgacg 853981 gtcttcataa aaaagcgggg agcaggcatg tgtacgaact gcatggttct atccagacag 854041 cagcttgtcc ggcatgcggc gcccgatatg atcttcccca tttgctggag cgggaggtgc 854101 cggagtgcac ggcggccgga aacaatgggg acatttgcgg aacggtatta aaaaccgatg 854161 ttgttctctt tggcgatgcc gtcatgcact ttgacaccct ttatgaaaag ctggatcaag 854221 cagatctttt attggttatc ggcacgtctc tcgaagtggc tccggctaga tttgtgcctg 854281 aggatgcaag cctgattccc ggcatgaaga aagtcatcat aaaccttgaa ccaacgtatt 854341 gcgacagctt gtttgacatg gtcatccatc aaaaaatcgg cgagtttgcc cgaagtttgg 854401 gcatgaaaaa gtgagccgct ttatgcgcct cactttttta ttcatgaaca ggaaccattg 854461 tgtcctctaa cactccgaag gaatagcctt tttcttttaa tttattgatt agtaccggca 854521 gcgcatttac agtagcagga agatcatgca tgagaattac atttgggcgg cttgaagagc 854581 tgtgttccat attctcaagc tgctgtaata cggcggtcac atactgtgaa ttccggtatt 854641 tccagtccat gctgtcgatc gtccaatccc agtacacaaa cccatctttc tccagattgc 854701 gaatttgtga ggcggttagt gacggcttgc ttccgtatgg cgttctgaca agatcggttt 854761 tatatcctgt aatgtcctgc agcgtgtcac gcgcctcctg catttctttt agcggagatg 854821 tcggtgtttg atagaacaat ctgttattgt gggtaacgcc atgtaaaccg agtgcgtggc 854881 cttccttttc tgctcttttc acagcctgct tgaattcgtt catccgcggt gacagcataa 854941 aaaacgtcgc ttttacatca gcgcttttca gtacgtcgag caagcgggtt gtaacggctg 855001 aagggccgtc gtcgaaggtt aagtaaaccg ttttatctcc catgttctgc tttgtctgca 855061 gatgttttat caggagatcg ggggagtcgt ttttcagctt aaggctttcc ttctcatctc 855121 gaagctggcc gtttgttgtg acagtgactt cctttgcttt cgttgaactg ttggaataac 855181 ccaaaatcac cataagcaaa agcagcacac ataaaactgc taaacttgca aatttaaaag 855241 caagcgaaac tgcagaagga gaagcctctc ctctcgtttg tcgcataaca atctctccat 855301 tggcataaaa tctctacata atgctgtaca gcaggcagct tatgaagatg ccttatgttt 855361 acaacctatg tattaccagt caagtataca ggaataaaac tggaaagcac atagaaaatt 855421 tgtcgaaatg tcagatttta aggaaaaaat aaactccttt ccgctataga tctcttgatc 855481 tttctgtttt tcagcttgtc caatatggta gaattagtga taatgacagc ttgaatgaca 855541 tcagggacat ctcgaaaagg gagggctttt atgaaggttt tagtcaatgg ccggctgatt 855601 gggcgcagtg aagcatcaat cgatttggaa gatcgcggtt atcagtttgg tgacggcatc 855661 tatgaagtga tcagggtgta caaaggagta ttgttcggct tacgtgagca tgcagagcgt 855721 tttttcagaa gtgctgctga aatcggaatt tcactgccat tcagtataga agatctcgag 855781 tgggacctgc aaaagcttgt acaggaaaat gcggtcagtg agggagcggt atacattcag 855841 acaacaagag gtgtggcccc gcgaaaacac cagtatgaag ccggcctcga gccgcagact 855901 actgcctata cgtttacggt gaaaaaaccg gagcaagagc aggcatacgg agtggcggcc 855961 attacagatg aggatcttcg ctggttaaga tgtgatatca aaagtctgaa tttactgtat 856021 aatgtcatga cgaagcaaag ggcctatgaa gccggagcat ttgaagccat tttacttagg 856081 gacggcgttg ttacggaggg tacatcctct aacgtttatg ccgttatcaa cggcacagtg 856141 cgaacacatc cggctaatcg gctcattctc aatggaatta cacggatgaa tattttagga 856201 ctgattgaga agaatgggat caaactggat gagactcctg tcagtgaaga agagttgaaa 856261 caggcggaag agatctttat ttcgtcaacg acggcagaaa ttattccggt cgtgacgctc 856321 gatggacaat cgatcggaag cgggaaaccc ggaccggtga ccaaacagct tcaggctgct 856381 tttcaagaaa gcattcaaca ggctgctagc atttcataaa tgaacgaaga aaagagcccg 856441 ctttttacag cggggctctt tttatttttt aacaaatcca atcaaaatgg agatcattgg 856501 cgatatatag aggaagaacg taaatgggat gtagtctatg actggaacac caagtgcgct 856561 cgccataaat gcgccgctga cgccccaagg aatcaatggg ttaattaatg ttccgccgtc 856621 ctctaatgat cttgtcagaa attttcgctg gatgtttcgt ttgtcatata aagatttaaa 856681 tgattgtccc ggtattaata tcgataaata ctgttcgccc gttgccaagt tgacgccgat 856741 gcttgagcag acagttgctg caacaagacg gccttttgag cggatgcctt tcatgacgcc 856801 ttccaatagt gcagaaatca atccgatttt ctccatcaat ccgccgagtg caaaagcaat 856861 cataatgaga gagacagagc ccatcatgga ttgcagtccg cctctgttaa taattttagc 856921 ggctgcctca ttgtcagttt cgaaagttgt gccattttgt aaagctgtca taaacgcctg 856981 caggctgctg tagggtacaa aaatagcagt caaaattccc gaggaaataa ttccggcagt 857041 cagaacgggg attactgata cccgtttcat tgccagcaaa acgactaaga gcggagaaag 857101 aagggcccac ggtgtcacgt ttgcagcatc ttttattccg gttatgacct gctgaatatt 857161 atcggttgaa gcagcgtccg ctgacactga tgaaccgaga aagtaaaaca gaacgacagt 857221 gatgagcaaa gctggaatgg ttgtgcccat catatggcga atgtgttcaa agattggtat 857281 ttcgcctatt ccggctgcaa agttggttgt gtccgacatc ggcgacattt tatccccaaa 857341 acaagcgccg catatgactg cgcctgctgt ccattcaagc ggaacgccag ccgcgctcgc 857401 cacgccgatc agcgctactc cgattgtgct tacagttgtc agacttgagc caacaagtgt 857461 gctgatgatc atacatgaaa acaaagcagt caacagaagg tggcttggtt caataaagga 857521 tagggcataa actgtcatag tcggtattgc gccgctgtac atccaggcgc cgattaagat 857581 gccgatcagc gctagaacaa taatcggctg tacgccgttt ttgatcccgt ctacaatccc 857641 tttttcaatg ctcttccagg gaaatccaaa ccataaagct gctgctgaaa gcatgacaac 857701 acttaaaaac agcgggatat gaggttctac atgaagcaag aataagcaag aaataataat 857761 gcacaacatg aatataaata aaccgacggc taacggaaac gtcagctttt tttgagaatc 857821 caaaataaca ccccatattt atctttaatg cttttgtgct tttgggcacg aaagcattat 857881 aacagaaaaa aacgaaaatc tatgtttttt cacaattatg aatataaaag aagtgagcac 857941 agggcgtgct cactttacaa tcaggacggg tatatccgat ttcgctgaaa gcttttcact 858001 tacacttccg aatattagct ttttcagcct gttttggtct ctgcttccgg ttacgatcat 858061 atcggcagaa atgcggtttg catgctcgat aattgattca gccggatcgc cttctaatat 858121 atcgatatct ccatctgcct gctgttcatt cagcatcatt ctggcttcgg cgatgacttc 858181 ttccgtacgg tcttcataga tcattggctc aggtgatgtt acatccgata tcagcggatc 858241 aggaacactt gtcatgcctc cgctgatata gcttgcctca gctgcgggtc tgggcgggtc 858301 gatgacggtc tgattgtctt tcatatcatg tgaatgggcg acggtaatag cggcatttac 858361 ggttttagca agatcaatgg ctgtcagaag cgctttctta ctattttcac ttccgtcaaa 858421 cgcaacaatg atacggtcag catggaacat ccttctcacc ctttcaaagc gtcttacaac 858481 actactaccc gaatttgagc acaattaacc ttttcctatt caagtaatga ttgacaataa 858541 aaggttttgt ttatatgatg ataaaaagat gaaatcagaa tggaaggagg gtttgctatg 858601 ccaaggaatt tgcgtgttta tcaaacagtt tcatattggc gcggcaaacc ttttgttctg 858661 ttttcgtgaa cggtttttta ggtcggaccg cgcgctgaaa agcgctgtgc gtaacatatc 858721 ggttaaaaaa ggcatggagc tgacgcttca tgcctttttt atatacaaaa tctaaggaaa 858781 gacaggtgta tgggatgtga agacaaatac agaggcgagg gcagttcgtg ccaaactgga 858841 tgaaaaaagc tgcaaggaaa aaatagaagg cggctgatga ggagatgggg atagatgttt 858901 tcagttttga aaaagcttgg ctggtttttt aaggcgtact ggctgcgcta tacgattgcg 858961 attgtccttt tattagcagt caatgtcatt gaaatgtttc cgcctaagct cttggggaac 859021 gccatagatg atatgaaagc aggggcattt actgcggaag ggctgctgtt ttatatcggt 859081 atcttttttg tgctgacggc ggccgtgtat atcatgtctt atttttggat gcatcagctg 859141 tttggcggag cgaatctgat ggagaaaatt cttcgtacga agctgatggg gcatttgctg 859201 actatgtcgc cgccgtttta tgaaaaaaac cgaacaggcg atttaatggc acgagggaca 859261 aatgatcttc aggccgtcag tttaaccaca gggtttggca tcttgacgtt agttgattct 859321 acgatgttta tgatgacgat ctttttgaca atggggtttt tgatcagctg gaagctgacc 859381 tttgccgcca ttatcccgct tccagtcatg gcgattgcaa tcagtctata tggaagtaaa 859441 attcatgagc ggtttactga ggcccaaaac gcgttcgggg cgctgaatga cagagtgctg 859501 gaatctgttt caggcgtgcg ggtgattcgc gcgtatgttc aggaaacaaa cgatgttcgc 859561 cggtttaatg aaatgaccgc tgatgtttat cagaaaaata tgaaagtggc ttttattgat 859621 tcactgtttg agccgacggt aaaactgctt gtcggcgcaa gctatctgat tgggctcggc 859681 tacggagcgt ttcttgtatt ccggaacgag ctgacgcttg gagagttagt gtcctttaac 859741 gtttatctcg gcatgatgat ttggccgatg tttgcaatcg gtgaactcat taatgtgatg 859801 cagcgcggca atgcgtcatt agatcgggta aatgaaactc tttcttatga aacggatgtg 859861 acagatccaa aacagcccgc tgatcttaaa gagcctggag atatcgtttt cagtcatgtc 859921 agctttacat atccaagctc aacaagtgac aatcttcagg atatttcatt tacggtgcga 859981 aaagggcaga ctgtcgggat tgcaggtaaa accgggagcg gaaaaacgac aattattaag 860041 cagcttttgc gccagtatcc tccaggtgaa gggagcatta cattttcagg tgtaccgatt 860101 cagcaaatcc ctcttgaccg tctccgcgga tggatcggat atgtgcctca ggatcattta 860161 ctgttttcac ggactgtaaa agaaaatatt ttatacggaa aacaggatgc aactgataaa 860221 gaggttcagc aagccattgc cgaagcacat tttgaaaaag atttgcacat gcttccgtcc 860281 ggtctggaga caatggtcgg tgaaaaaggc gtggcactgt caggcgggca gaaacaaaga 860341 atttcgatcg cgagagcact catggcgaat ccggaaatct tgattctgga tgattcactt 860401 tccgctgtag atgccaaaac agaggctgca attatcaaga acatcagaga aaaccgcaaa 860461 ggaaaaacga catttatttt gacacaccga ttatccgcgg tagagcacgc tgacctgatc 860521 cttgtgatgg acggcggcgt cattgctgag agaggcacgc atcaagaact gctggccaat 860581 aatgggtggt accgggaaca atatgaaaga cagcagctgt tcactgcgga agaaggggga 860641 gcaggggcat gaaaatagga aaaacgttat ggagatacgc acttctttat cgaaaattgc 860701 tgatcacagc cgtccttttg ctaactgttg ccgtcggtgc agaactgact gggcccttta 860761 ttggcaaaaa aatgatagac gaccatatcc tcggcattga gaaaacatgg tatgaagctg 860821 cggaaaaaga taaaaatgcc gttcagtttc acggcgtctc atatgtcaga gaggaccgat 860881 tgcaggagcc tgtttcaaaa gcaaaagaag cgcatattta tcaagtggga atggcgttct 860941 attttgttga tcaggctgtc agcttcgacg ggaatagaac ggtttctgac gggaagctga 861001 cgatcacaaa cggagacaag agccgggcat atgctgccga aaagctgact aagcaggaac 861061 ttttccagtt ctatcagccg gaaataaagg gaatggtgtt actgatctgc ctgtatgggg 861121 gcttgcttgt gttttcggta ttctttcaat acggacagca ttatctgctg cagatgagcg 861181 ccaatcggat tattcaaaag atgaggcagg acgtgttttc gcacatacag aaaatgccga 861241 ttcgctattt tgacaacctt ccggccggaa aagtcgttgc gcggattacc aatgatacgg 861301 aggctattag ggatttatat gtcacagtgc tttcaacatt tgtgacaagc ggaatctata 861361 tgttcgggat attcacggct ttgtttctgc ttgatgtgaa gcttgcgttt gtatgtctgg 861421 caattgtgcc gattatctgg ctgtggtcgg tcatataccg gagatatgcg tcatattaca 861481 accaaaaaat ccgctcgatc aacagtgaca ttaacgcaaa aatgaatgag tcaattcaag 861541 gcatgaccat tattcaggct ttccgccatc aaaaggaaac aatgagagaa tttgaggaat 861601 taaatgaatc acatttttat ttccaaaaca ggatgctgaa tttaaactcc ttaatgtccc 861661 ataatctggt caatgtcatc cgcaatcttg cgttcgtctg tctgatctgg cattttggcg 861721 gtgcgagcct gaatgcggcg gggattgttt ctatcggtgt gctgtacgcg tttgtcgatt 861781 atttgaaccg gttatttcag ccgatcacag gcatcgtcaa tcagttttca aagctggagc 861841 ttgcaagggt ctccgccggg cgtgtttttg aactgcttga agaaaagaat acggaagaag 861901 cgggtgaacc ggcgaaggag cgcgcgctgg ggcgggttga atttcgtgat gtgtcatttg 861961 cgtatcaaga aggtgaagag gtattaaagc atatttcctt tactgcgcaa aaaggcgaaa 862021 ccgtagcgct cgtcggccat accggatcag gaaaaagctc gattttgaat cttctgtttc 862081 gtttttatga tgcgcaaaaa ggtgatgtct taattgatgg aaaaagcatt tacaacatgt 862141 caagacagga actcagatcc catatgggta ttgtgcttca ggacccgtac ttattctcgg 862201 gcacaatcgg atctaacgta agtctggatg acgaaagaat gactgaagaa gaaataaaaa 862261 atgcactgcg gcaagtcggt gctgagcctc ttcttaagaa gcttccgaag ggcattaatg 862321 agcccgtgat tgaaaaaggc agcacgctat cctctggaga gcggcagtta atttctttcg 862381 ctagagcttt ggcgtttgat cccgcgatct tgattttaga tgaggcaacg gcgcatattg 862441 atacagagac agaggccgtg atccagaagg cgcttgatgt cgtcaaacaa ggacgcacca 862501 ccttcgtcat cgctcaccgg ctttcaacaa tcagaaatgc tgatcagatt ttggttcttg 862561 ataaaggaga aattgttgag agagggaacc acgaggaact gatggcatta gaaggccaat 862621 attatcaaat gtatgaactg caaaagggac agaaacattc cattgcataa cgctcaaaaa 862681 cccaaaacaa tcgtgttttg ggtttttggt ttatgtagtc aataagccag tccgacacgg 862741 tttccgacat actcacctgt aacgagctca cgatataaaa agtccgcagt atcgccgacc 862801 gaaatgcttg tgccgccctc aggcaaaacg ttacgctccg tacgataaac gccggttgct 862861 gttccgtccg ggaggtaagt ggggcagatg attgtccagt ctaatgatga ttctttaagc 862921 atttcgtata cttttgcatg ctccttggct gcgcgggtct gctttcgttt cgattcattt 862981 gtttcaaacc ggtattttcc cggttcatat cgggaatcta ggatccctgc ggtgccgatc 863041 gtaataagcc gtttgatatg ctgttcctcc ataacggaga gaatgtgtgc catagcagtt 863101 gacaaggtat catcaccatc tgtgcctaga cagctgatca cgatttcagc attctccatt 863161 atttttttca catcttctaa gcggcgggcg ttccccatga cagttctgtc ttttgaaagg 863221 ggaagatcag catgttgaga tctgatcaga gcgaaaatat caaatctttc atctgctgca 863281 gcttgtgtta aaaaggcttg tccgacgcgg ccgctggctc ctaataaagc gattttcatt 863341 aaaaaacctc ctcgcctttc attataaaag gatgttctca gtttgaacag cgcgggaaag 863401 aatacctgta caaataaaca gaacgatggg aaacatattc atgaatcatg gatacactta 863461 cgaattgaac cagctcccaa ttcacaatgg tgatgaatga caccccgatt ccctcccttt 863521 ttttctagga tatgtggagc aggaaaaaag ggtgacaaaa taaagagagc gcggaaaccg 863581 cgccctctat agccatatat tgaattgtta ttgaactctg ccgcccattt gctgctgagc 863641 gaaagatact aaacgttttg tgatttctcc tccgacagaa ccgttagcgc gagaagttgt 863701 gtccgctcca aggttaacgc cgaattcaga agcgatttca agtttcattt gatcgatagc 863761 ctgagctgcg ccaggaacta gtaagtcatt tgaagagttt tggttagcca tgtgtaaaat 863821 ctccttttta tttagtatgg ttgggttaac tggagttgca ccaatctgtg aacccttctc 863881 gggtgtcact gccgcctcgg cgtaacccaa tgctttgccg gcttgttact acgtattatg 863941 ttaaaatggc cggaaaatca tgcggagaat tgtgtggtaa atcttgagaa ataaaaaaag 864001 cttagccgtt taggctaagc tagtcataaa tatgaaaaag catcagttca tgtatctcgt 864061 ttgtaagagc aggctcgtca gcgcgggcgg gaaacaagtc tccccattca atctcaccgc 864121 tcttatgata gatgccttca taatgggtcc ctttataata aaatgaaatt ttccatccgg 864181 gcagcttttc ttttgggaac aaaggtttcc agctgaaatg agaaatcatt acggccacgc 864241 tccttacatt tggtatcaat tgacctaaat aaaaacggct tatgttcatt gtatcattgt 864301 ttcagaacat cattgaagag gcctaaatat gcagtttgtc ccagctttgg ataaagataa 864361 gcccgcttta ttaaaaaagc ggacaggtta cgaaggccac aatgcttccg gagatgtgat 864421 tgccttctca gataaatatg acgcgtattc aaaacttctt cgttttgtaa gagaatcaac 864481 atgatgcaaa tttggatgag aaaaaatgct tcggcccggg cgcgaattcg cttcaaacat 864541 ccatacttta ccgttctgat caatgccaaa atcgaaacca atctccccga taaatccctc 864601 gatatgatca tgaaggacat ggcttgcagt cagtgccgct gcagaaagct ttttaatgac 864661 ctcaactctt tcagcgggat catcgtatac ttccgcaagt gtctttacag tgccgccgtt 864721 agaaagatgt gttgtaatgc tgttctttcc ggaaattttt acggcgattg ctgtcactgt 864781 ccattttcct tttctgtttt tattggtatg gacacggaaa tccgctggtt tgccttgaaa 864841 ttcgatgaga tcaacacctt gctgaatgag aaagtcggac gggttgtgat gtttttgaaa 864901 ttctgcaagg aatgaggcgg catcggaata atcaattgat gtaaaagttt tggcgtcatt 864961 cgtatgcttt accgtcaggc cgccatctgt tcttgtcagc tgataaatgc cggtgccgag 865021 tgctccattt gccggtttga tatagacttt tttgtatgcg ccacagagct catctatcag 865081 ctccacagac ggtgtcagct cggatctagg caaaaagggt gccgttcttg gatctttttc 865141 gagcaattga tgaacgttcc atttattgaa aaacgtttta ttaaaccatg ggatctgata 865201 ttcatcgatc agcctctttt ttgtatgttg caagagaagt gaatcttcaa tttttcggtt 865261 cggcaaacgg tcataaacga cgttcggcaa tggaacgatt tttttctccc agccgttttc 865321 cctgtaaagg aggccttcaa tcgtgccttc ctcccaattg atttggtgcg cgccaaaaac 865381 gaagcagtag cccccggctt gctcgtgtaa cgtgacaagt ttagaaaaaa agagggaacg 865441 atccttaaat gggcgttcaa gagatacagt aaaccctgcc gtaaagatgc cgactaacgg 865501 cccgatatgc actgtatgat catgaatcag tatatctgcc ctgcttcggt ggggaagcaa 865561 aagctcatga aacagatttt cagagagaag cacggtttgt tccagatgcc gtctgtaagc 865621 aacgtggcat ctgacaacct tcgttccgaa tgcggcatgc aaaagtccgt cttgcttcag 865681 cgaagagggc agaaacaggg tgttttcact ggttttgtct atgccgatca aaaaccgttt 865741 aggattcacg cggaagaact cctttctggc tttgctcaga aaacagatat tggcagcgtt 865801 ttaggggaca agtgtacagc tgttcttttt gctcgggaga gacacgcagg attgacttcc 865861 tgcctggttt ggaattgata tctaaaatcc aaattctccc gtcctttgca agacatatat 865921 caagaccgag ttcaaacaac ggcccatagc gctcgtcaag ataatacgga accgattggg 865981 taattgaaaa cacatcatct agtaaaacca cttgctgttt tttcggtata tcttcaaacc 866041 aggagtcaaa tgtcagcgca tcagatccgc ctgacaaatt ggccagcagc ccgtgtttgt 866101 atccgcgtct tactgccttt ccgactgtat tccattcacc tgcttcgttt ttttccataa 866161 acagacgaat atcacaaggg tattgttcct tatcttgaat gtttaagtaa ggctgaagca 866221 aatattgatg ctgaagcact tttttgcacc atgttttaaa agaagtctgg ttggaaaacg 866281 tttttgtctg cttatccttt ccgatgtgat aagtagcagt gatgtttttc ttgcccagct 866341 tcaaaagaat cacgcctctg cctcccgcgc cgaatgccgg tttaaggatg caggcttttt 866401 ctttggataa aaaggagtga atttgttcgt agcggctcac ctttatcgtt tcgggaatat 866461 agggattgat tacagagtgc tgctgcaaat cgtgaaggac ggtccactta tcgggaagac 866521 cccgcccgat aaattccgtt ttcggatatt ttttgagcca ctcaacgatt ggttttgctt 866581 tttgggaatg tgaatccttg ccgtaaaaac agcgatcata aatataatct ggaatcgcca 866641 tttcagtttc gttccatgtg ctgctggccg aatgatagac cgatgctttg acacgcaaag 866701 tgtcaggtga aatatcaaat ggtgtaaacc ggatgaaacg tatgccgaat tcgggtgctc 866761 ttttggccag ttctgcggaa taatccgctt catgctggcg ggataaggac ataaaaccga 866821 gtgttatcat ggtgagactc ccccttttat tcaaaagctg ccggcgggtg tccgcagctt 866881 tacactaaat acatgtaaga cgaacgcagc tgacggtatt ctactttaca gaatacgatt 866941 ctccaccttg ccctattcca aaagaacaag ctgattttct aagaacagga atttgtctcc 867001 tcgtttgcta agtgattgca tgagcctcta taatacgtat aggtacataa tctatatgaa 867061 aaaagctgaa gcacagatgg aggaagatga ataggaatgg gtattgcagg aacctttatt 867121 tttatgatcg tgatcggcgc tgccattgga gcggtgacca atcatttagc aattcaaatg 867181 ctgtttaggc cgtataaagc gtactatttg tttgggaaac gagttccttt tacgcccggg 867241 ctgattccaa gacggcgaga tgaacttgca aaacaaatgg gactgatggt agtcaatcat 867301 ctcttaaccc ctgaaggcat taaaaagcgg ctcgtctctg atgcagccaa aacgcaggct 867361 cttcgagtgg gggaacagct gattcaaaag ctgtcacttt ctgaagtgac agtaaaagaa 867421 gcgcttgaaa aagccgggat gaagcgcccc gaaaaagctg ctgatgcatg gatcagcagc 867481 tggaccgatg ataagctgca tgagcttttc cgccaatacg gggaccaatc gttaaaagag 867541 ctggtgccta tagaggtgca ggaaaagctt gaggaaaaaa ttccgatgat ttcaggatat 867601 atattgtcac ggagtgtccg ttattttgaa agtgatgaag gaaaaatccg tcttggcaat 867661 atgattgatg actttttaaa agagcgcggc atgcttggaa gcatggtgca attgtttctt 867721 ggcaattcaa gccttgcgga tcgcgtgctg ccggagctgc tgaaattctt gcgcaatgag 867781 gaaacaaata aattgctttc tgatctctta aaaaacgaat ggggcaagct gagggagtat 867841 acgtttaatg aagcagatga aaaatggaat gcaaaggcgc tcattttcag tttgaaacga 867901 agagtgctgc aagcattttc gactgcccct ttcttcaaca atacgattgg cacgcttacc 867961 gtccgctatg aatctgagct gacccagcaa atgctgccgg cactattaga caaattgctt 868021 gaaggtattt cgtccaacct tgaaagtgtc ttaaaacggt tgcgtcttga ggaaatcgtc 868081 aaggagcagg tggatcagtt cccggtggag cgtcttgaag aaatggtgct gtccatttca 868141 aaaaaagaat ttaaaatgat tacctatttg gggggccttc tcggcggaat tataggcgcg 868201 attcaagcat tgtttgtcat ccttttttaa gaagaaatgg tttttgatta atgaaaggag 868261 ctccatagtc tgttatagtg gagtggtatg tcaaacggca atgatgaaag gagctattta 868321 caatggctgt taatttttat gatgtagcgt atgatctgga aaatgcatta cgcgggagcg 868381 aagaattcac ccgtttaaaa aacctttacg acgaagttaa cgcagatgaa tcagcgaagc 868441 gcatgttcga aaacttccgt gatgtacagc ttagactcca gcaaaaacaa atggcaggag 868501 aagagattac acaagaagaa gtgacgcagg ctcaaaaaac agttgcgctt gtacagcagc 868561 acgaaaaaat ttctcagctg atggaagcgg agcagcgcat gagcatgctg attggtgaat 868621 tgaacaaaat cattatgaag cctttagaag agctttacgg cagtgttgaa ggctaataag 868681 caaaatccct tcttggataa gaagggattt tttattcact cagcaaactt ggaaatccaa 868741 tgaatctttt acctctccat tgatgatgac tgataatgta tgaattcctt tgtaatgctt 868801 tctggtggtt aaatccttaa aggattggat tcttgtgtat gacttcgttt cgttttttcg 868861 tatatttgtt tctgttattt taaatacttt ctgatgacgc tggcctcttg cttttacaaa 868921 atcaattgcg tactcaattc ttactttttg atccctgtct gaatgaatat agaaagaaaa 868981 ttcaaggctt tcgccaataa ctatacgttt gggctggcat gttaaatcat gtagttgtat 869041 cgaatcagca ttttcataac caaaaagcgc taaggcctgt ttatcaccct tttttaataa 869101 ggtccgatag gcgtgtttga taatccagtc tgtatgggga tgtgttccgt accattgatc 869161 tgcgactttt ctcagtaaat gaggatgcgt ttttgatata tcattaaggt tgttggccac 869221 gctttttctt acatataaag actcgtcctg catcagcttc tcaaggatcg gcaatacggg 869281 ggaagggtcc gatttcaaag ccggtatcga ttttccccat ggcaggcggg gcctgctgcc 869341 ttcgctcgca agtcttctca cgtgttcatt tttatgctca gaccatgcaa gcaattgtgc 869401 aatcatcttt tcttgatcta acagcaaaaa aggccttaca gcaaattctg aggtcgaata 869461 ttgcgtaaag gattccaatg cctttattga ttcttcccaa tgcgctaacc cgtactgttc 869521 cacataatct ggaaataaaa ttccgctgag tcctttaaaa tgaggggctg tatcccgtaa 869581 aattgtgagc gcttcaacgt attgttttgg caaagtttcg tataaagaaa ctgtcacgcg 869641 gcgcatccgc tcttttaaag tgagttcagg ccagtcctcc agccgtaatg tatccaagaa 869701 tctgtttttg ttaaaatcag gataggatga ccttacatga tggatcaact gagatatcag 869761 ttcttcatta tatatttctt ttaaatcagc catataaaca ccgctttttc gtttattatt 869821 tatattgtat gggaatgtac gttctggatc aagtgtatag tcctaaaaat taacaactga 869881 tcctaccacg gatatacaaa agttggttac tttttttagt taaaaaaacc cttgtcatcg 869941 gaaaggaaaa ctgagataat aacattgaaa gcgcctacac ttacctattt caaatggata 870001 cggtcgcata tcatgccgtt atatagaggg gataagcaac agagagtaag tgttcggagc 870061 gcatcattgg tcaaacaagg ggttcctgat acatgatttt tcgtaaatcg aaataacgat 870121 attagggaga atggctgctt cgatcgtatc ctatcaacaa gccatacata aagtctgctg 870181 agccaggctt tttttgcttt aagaaaaggt tgttctaaac acagagacag ggtcatatcc 870241 tatacacaag tacagtcatc aaggaggggg acatctctgt gtcaaaacaa ttgcttgcct 870301 taaatataga tggagcgctg cttcggtcga acgggaagat tcatcaggca acgaaagacg 870361 cgattgaata tgtaaagaaa aaagggattt acgtcacact tgtgaccaac cgtcattttc 870421 gctcagcaca gaaaatagcg aaatcgctaa agcttgatgc caagctgatc acccatagcg 870481 gggcatatat cgctgagaaa attgacgccc cgttttttga aaaaagaatt tctgatgatc 870541 atacctttaa cattgttcaa gtgctggaga gctatcaatg caatattcgg cttcttcacg 870601 aaaagtattc catcggaaac aagaaaaagg tgaattcgaa tttattaggg aaagcactca 870661 ttcatccgtc tgacccgatc ttttatccag tccagttcgt tgaatcatta agcgatctcc 870721 tcatggatga gccggtgagt gcacccgtca tcgaggtgta cacggagcac gacattcagc 870781 atgacattac agaaacgatt acaaaagcct tccctgcggt ggacgtgatt cgcgtaaacg 870841 atgagaaact gaatatcgtc ccgaagggtg tctcgaagga agcgggtttg gccctcgtcg 870901 cttcagagct gggcctgagt atggatgatg tcgtggccat tgggcatcag tatgacgatc 870961 tgccgatgat cgaacttgcc ggtcttgggg tagcgatggg gaatgccgtt ccggaaatta 871021 agagaaaggc agattgggtt acaaggtcca atgacgagca aggtgtcgct tatatgatga 871081 aggaatattt ccgaatgcag cagcgaaaag gatttcttga taagttccac atgaaacgtg 871141 tgtaaaaaag ccgctcgcgc cctgacaggt gcggcggctt ttttgccgga ttgattttag 871201 cagtttattt ctgtacacta aagaaagttt tgaatctgat aaattaggtg atgaagttgc 871261 aaattaaaat agaaggcata catgatgacc gcctgcatcg gcctctgcaa aatattgcaa 871321 atttgtttta tgaagagtgc gagcttgcgt atggcggaga ggagcccgca gattttgtca 871381 tttctttagc gttgtcacaa acggatgagc atgtgacggt ttctggagaa gtgaagggta 871441 ctggcataaa ggaacagcat acaaaattct tttctccaga catgactgaa aaagaagctt 871501 ttaagcaagt gaaaaacaca atttcttatg tgtatctcaa tcttcttcag gcgcatacgg 871561 gcattacgca gaagtgggga atcctcacag gaatccggcc cacaaagctg cttcataaaa 871621 aactgcaaag cggaatgtcc aaggagcaag cgcatgctga gttgaaaaaa gactatttaa 871681 ttcatgatga aaaaatcatg ctaatgcagg aaattgttga ccgtcagctg gcggcagtgc 871741 cggatttgta ccgagtaaag gatgaagtca gcatttatat cggcattccg ttctgcccga 871801 caaaatgcgc gtattgcaca ttccctgcgt acgctatcca aggacaggcg ggcagagtcg 871861 gctcattcct atggggactg cattacgaaa tgcagaaaat cggtgaatgg ctgaaggagc 871921 atgatgttaa ggttacaacc atttactttg gcggcgggac gccgacaagc attacagcgg 871981 aggagatgga tctgctgtat gaagaaatgg tccgctcctt cccggatgtg aaaaacattc 872041 gtgagattac ggtggaggcc ggtcgtcctg acacgattac agaagaaaaa ctcgccgttt 872101 taaacaaata tgacattgat cggatcagca tcaatccgca atcctacgaa aacgaaacgc 872161 taaaggcgat cgggcggcac catacggttg aagagaccat tgagaaatat catctgtcac 872221 gccagcacgg catgaataat attaacatgg acttgattat tggtttgcct ggggaaggcg 872281 tgaaggagtt caggcacagt ctttcagaaa cagaaaaact gatgccggaa tcccttaccg 872341 ttcatactct ttcatttaaa cgggcgtcag aaatgacgag aaacaagcat aagtacaaag 872401 ttgccggcag ggaagaggtt tctcaaatga tggaagacgc ggtagcctgg acgaaagagc 872461 atgggtacgt gccttattat ttataccgcc agaaaaacat tcttggaaac cttgaaaacg 872521 tcggatactc tttgccggga caagaaagca tctacaacat tatgattatg gaagaggtgc 872581 agacgattat tggcatcggc tgcggcgctg ctagtaaatt tattgatcgg gatacaggga 872641 aaattacgca ttttgcgaat ccgaaagatc cgaaatcgta caatgagcgc ttcgagcact 872701 acacggacga aaaaatcaaa tatttagagc agatttttga aaaaacgaca aagcagcact 872761 gattacagtg ctgctttttt tatccctgtt tttttgcggg ctgaacctca ggcttccatt 872821 taaatacctt gttcagcaag cggtaaattc gttttgattc ctttgtgaca agcggtccca 872881 aaatcgccag aatgaggaca tataatgcgg caaacggctt taatgtggcc gacagtccgc 872941 cggctatccc gagattcgca acgataatcg aaaattctcc ccgcgatacg atcgtcagcc 873001 cgatattcga tgaagcctta tgagaaagcc ctgcgcgtcg tcctgccacc attccggcga 873061 taaaatttcc cagaatggtc aaaatcactg cacccaacgc aagccaaacc gcttcaccaa 873121 gcgaaaacgg atcgatgctg aggccgaagc tgaaaaagaa catcgcaccg aagaagtcgc 873181 gaaacggaac aacgaggtgt tcaatcctat cggaatgctc tgtttctgaa aagaccaaac 873241 cgagcagcag cgcgccgatt gcttctgcta catgaatcgt ctctgaaaaa ccggcgataa 873301 aaaagagtgc tgcgaaaatg acgataataa acacttcgtt tgagcgaatg tccaacagtt 873361 tgttcaacag cggcgggagt tttcttgctg cgataaaaaa cagcagcata taaccgaagg 873421 cgatcaaaat ggacaagagt gcactcccta cggatgtcgc atcacctagt ataaggccgg 873481 aaacaacgga cagatatacg gcaaggaaaa tatcttcaaa catgatgatg ccgagaatca 873541 attcggtttc cgggttggcg gttcttttta aatcaacgag cacttttgcg acaatcgcac 873601 ttgacgagat tgtgatgacg cctgcgagga tgaggacttc cagaaaggaa aatccggtga 873661 taaacccgta aagcagtccg aggctgaagt taatcaaaat ataaatcgtc ccgccgaccg 873721 cgattgattt tcctgatttg attaacttcc cgacagagaa ttcgagtccg agatagaaga 873781 ggaggaacag tacgcccatt cgcccgaaaa actcgatgat ttcactgctt tgaataaatg 873841 ttagatcaat aatccccatt ttcggcgcgt gcggtccaac aagcattccc agcacaatca 873901 gaaacggaat aatcgaaaat ttaattttat tggcgatcac actggcgatt gccacaagca 873961 caagtgcagt tccgacttca aatacaagat ggtccatcgg ggctcacacg ccctctccag 874021 aaagaaaatc gtgaatcagt ttcttcagat gctttctctc acctgagagg acaagggtgt 874081 cattttcttc aataatcgaa tccgctccgg gatttaggag cttttcctgg ttgtgtttga 874141 taatcgcaat aacagtgaca tcgtaattct ggcgaacatc aagctcaccg agtgtgcgtc 874201 cgatcgattt ggcgcctttt tcgaccttaa accattcaat aataagatcg ctgaaggcca 874261 tttcgatgga ctccagagct tgcggtttat agaccatgcc cccgagaata gctgcaattt 874321 gccttgcttc agaatcatcc aatgaaatat ttgaaagaag ctcatccggg tcccggtcat 874381 taaaccggta aatttccctt cttccgtcat catgaatgat aatcgtcatt ttttcgtggc 874441 ttcttgtttc gatttcaaac tttttgccga tgcccggcag atcgttttct ttaatattca 874501 atgaaaatcc ctccgaatgt agtgttggca gtatggggtg agttacaaat aaaacttgag 874561 caaattatat tcggaggtaa ttagactggt atttgacagg gacggccaaa gccttttcca 874621 gcctgtttat cagcggttcg tcaagtggtt tgacagagag ctgcctgaca gactgcgcca 874681 gcgggctgta ctctttgatc agctcagccg ggtgcatgct gcccggcgat ggcgtttttg 874741 ccgattgtgt ttcctgcgga tatgaagaca taggcacata gctgtcagtg cttgcttcaa 874801 actgggaagg cagaaccacg tccgaagggg gaaagtacac cataaataaa cttaacagaa 874861 aactgatcag caatttatcc atgttccttt cctcccttct catcaagata tcccttcttt 874921 ttcactatat aaaactttat gtttccattc aaacaatatg catttttcag tatctattga 874981 ccttgaaaaa taaaaaggtt tatttgggga tggcggggaa tgtataggag aaagaaaaaa 875041 gtaagcgcat acatggaggt gcttttaatg gagtttgttc aatatgcatg taatggggcc 875101 gttgcagaga ttatcctgaa tcggcctgat gcccatcacg ccctgaatga acagatgctg 875161 tctgaattga aggaggcagt cgaaatggcg gctgcaagcg aggcgctcat cgttctcctg 875221 agaggaagcg ggaaaggctt ttcggccggc ggtgatatca ggatgatgac gtcagagcat 875281 gaccctgacc aatttaaacg gctgatggat acgattgagg ctgtcaccct gaatttatat 875341 cagatgaaga aagtgacaat tgcagccatt catggtgctg ctgcgggact gggcctgagt 875401 ttggcgcttt gtgcggacat tgtgctcgct gaaaaaaacg ccgttctcgc gatgaatttt 875461 atcggcattg ggcttgttcc ggacggcgga ggacattatt tgctgaagaa aagaatcggt 875521 gaagcaaaag cgaaaaaact gatttggagc ggaaaaaaac tatctgcctc ggaagctgcc 875581 gatatggggc ttcttgatgg gacatttgcc ggagaccctg ccgaaggcgc aagacccatt 875641 atcgaaaccc tgttggcctc ccctcttttg gcgatgatcg aaacgaaagg tatttttcaa 875701 agcctccaaa ttgaagaact gaaaaaagtg ctatcccttg agcgcagcgc ccaagagaga 875761 atgagaagga ccaaggatca ccaagaagga atccgtgcct ttttagaaaa acgggagccg 875821 aagtttcaag cgtaacagat cagccggaaa gctgatcatc tgtgaaacaa aatcagcttt 875881 ccggctgcat tgactaaacg atgagtatga ctatgaagct ctttttcttt taagagggct 875941 tcaccatgcg tttttgccgc ttcttcatgt tctgcctcga attgctcgtt taccagcgtg 876001 ttccccgaag gatcaaatac ggtaaggaaa taatcagcca tcaggtttct cctccatttt 876061 aaggtttatc agtctttctt catttatatt ctaaaaagga aatcaaaatc ctttattatg 876121 ctttatccaa aattagtata taatgggtca gggaaggagg agattcagtg cttacaattg 876181 atcacgtaac gaagacattt ggagattata aagccgttga cggattggac ttagatattc 876241 cggaacagca aatgttcggt ctattaggcg caaacggagc gggaaaaaca acaacgtttc 876301 gcatgatcct aggattatta agcattacgg agggctcaat cagctggaag ggccgtcctg 876361 tgaattatca tatcagcaac aaaatcggtt atttgccgga agagcggggc ctttatccga 876421 aaatgaaggt aagggatcag ctcgtctatc ttgccagatt aaaagggatg gagaagcgag 876481 aggctgtaaa agagctcggg acatggcttg aacgcttcaa tattacagat tacgagaata 876541 agaaggtgga agagctttcg aaggggaatc agcagaaaat ccaattcatt tcggcagttt 876601 tgcataagcc ggagctcctg attcttgatg aaccattcag cggcttggac cctgtcaatg 876661 ttgagctgct aaaagaggcc gtgatctcgc tgaaaaacag cggtgtttct attttatttt 876721 caagccatcg gatggaacat gtggaggagc tttgtgagaa cctttgcata ttgcagaaag 876781 gaaaaccggt tgtacaaggc aagctgaagg agatcaagcg ttctttcggt aaaaagaatg 876841 ttaccattca ctccgatgac gatctgcgct ttttgcagtc ccatgaaggc attcttcaat 876901 ggaaggaaac ggcagacggc gtcaagctgc agattgccaa tgaagacatt tctcaagaga 876961 tttttgcgat gctccaagga aaagggttta tcagaaagtt tgagcttgaa gagccgtcac 877021 tgcatgatat ttttatagaa aaggtggggg ccgtctatga ataaattttg gatcatgctt 877081 tctcatacat acaaaaataa gattatggca aaatccttta ttatttcgac tgtcatcacg 877141 gtgctgcttg ttttagttgt aacgaatctg gagtcgatca tttctttgtt tcaaggtgac 877201 gatgcgaaag aaaaaatcgc cgttgttgat gaaacaaacg aattatatcc ggttttttct 877261 aagcagctga aagcggtgga tacagacggc gatcttgatg tgaagctgtc gaagcaatcg 877321 gaggatgagg tcacaaagca agtcaaagat gaatcactcg atggcatgct catcatcaaa 877381 cgagatgaaa aagggaccat ttcaggaaca tataaagcgt taacgatttc tgatgaaagc 877441 acgtatcaaa cactgcagca ggcgctgacg caaaccaaaa cagctgtcgg aacagcggag 877501 ctcggcgtgt cgcaggaaac gattagcagc ctttatgcgc ctgttactgt ggggcagaag 877561 gcgctgaaag aaggggcaaa gtctgaggaa gagcttggcc agacggtagg gcttgtttac 877621 attatgctgt tcgtcattta tttctcggtg attatgtatg ccagcatgat agcgatggag 877681 gtcgcaaccg aaaaatcttc gcgagttatg gaaatcctga tctcaagtat gccgccgatc 877741 cagcaaatgt ttgcaaagct gcttggtatc gggcttgtcg ggatcacaca gcttgctatt 877801 attataggag ccggctctct gtcgcttaag ctgaaccaaa agagcgaaac ggcttcatct 877861 gtcggcggat tccttaattt gaccgacgta tctgcaacca ctgtcatcta tgctgtcatt 877921 ttctttttgc tcggatactt tttgtacgcg acacttgccg cgtttctcgg cagtgtcgtc 877981 agcagaatag aggacgtgca gcaaacgatc acgccgatga cgcttttggt tgtcgccggt 878041 tttatgatcg cgatgttcgg tttgaatgcg cctgacgcag gatttattac ggtaacttcg 878101 tttattccgt tctttacgcc aatgattatg ttcctgcgcg tcggcatgct tgatattccg 878161 ttctggcagg cggctgtcgg aatcggaatc acactgctca ccattgtcat actggccgtt 878221 atcggcgcca gaatttataa aggcggtgta ttaatttacg gcaattcaag cgcgttcaaa 878281 gcgatcaaac aagcgctacg tttagcgaaa aactgattgg aaaacagcct ggggattctc 878341 aggctgtttc tttattgaca gaacgtgcat tcgcaagaat tcggtgctaa aataagggta 878401 cttcatcctg gaaaggagca gaatgttgac tgatctaacc tttattcatg cggcagatct 878461 tcatcttgac agcccgtttt acgggatatc gcatctgccg gagccgattt ttgcccggat 878521 taaagaaagc acgtttgcaa gcgtgagaca tatgatagac gccgcagtga gagagcacgt 878581 tgatttcatt ttgcttgcgg gagatctgtt tgatgaagcc aatcgaagct taaaggctca 878641 gctctttttg aaaaaacagt ttgaaagact cagagagtgc ggaatttcgg tatacgtcat 878701 ctttgggaat cacgatcatc ttggcgggga gtggacgccg attgaatggc ctgagaatgt 878761 ccatattttt tcgtccgctg ttccagaaga aaaatcgttt tttaaagaag gcaggcgcat 878821 agcaagcatt tacggcttca gctatcaagc cagagcattg atggaaaacc aagccgcccg 878881 ctatcggaga tcaactgacg caccgtttca tatcggcatg ctccacggca cgctgtcagg 878941 atctgaagga cacgatccgt attgcccgtt tacacatgac gacctcgtga aaagcgggat 879001 ggattattgg gcgcttggcc atatacataa acgccaggtt ctatctgccg agcatccggc 879061 agtcatttac ccgggaaaca cgcaagcacg ccatataaag gagacgggag ataaaggcta 879121 ttatctcgtt catgtgacaa acggagatat atcttatgaa tttcagagag cgcatgatgt 879181 cctgtgggaa aaagcggcgg ttgatgtgac ggaggcaaag aatatgacag ccctcttcca 879241 aatggtggag gacacgtttt cgaagctgcg gaaaaagggg agccctgttt gtgtaaggct 879301 tgttttacaa gggacggcgc cggaatggct gctggaggcg ccaaaaggca ccttggatga 879361 gtttcttgaa gctcttcagg aacaagaagc ggaagaggaa cgtttcgttt ggcctcttag 879421 attggacgat gagacagaaa acgaagcaaa cctaacaaac cttgatcctt tttttggcgg 879481 tttatttgaa gacattgatc gcagcgatct gtcagacgtg ctggaagggc ttgagcggca 879541 tccagtgtat agaaggcacg cggaccggtt tagccaagag gaggtaaagg aaataaaaga 879601 gcaggcacag ataatattga aaagacagct taaggtgctt gatacatgag gcggtgacag 879661 ctttgcgaat tatatcttta catatctacc aatacggaaa attttccaat cggacctttg 879721 acttttccgc ctctcctgtc caagtcatct acggattaaa tgaggcagga aaaacgacga 879781 tgatgtcatt cattgaaagc atgctgttcg gttttccgaa aacgaaaaag tatgaaccga 879841 aaacaggcgg tgtctacggc ggtgttcttg aagctgaaca tcctgagtat ggggtgctga 879901 agatcgaacg gacgaaaggg actgccgaaa aactaagcgt gtacacagaa aagggcgaag 879961 taaagcaggg agatgtttta aagcagctgt tccagggcac agacaggtcg ttgtacaaag 880021 ccatatattc gttcgacgta ttcgggctgc aggaaattca cgcctttaat cgggacaaga 880081 taggggaatt tttgctcttt tccagcttgt ttggtgctga agccgtatca aagcttgatt 880141 caaggctgac gaaggaaagc gaaaggctct ataaaccaaa tgggcgaaac cctcaattga 880201 atcaggagct ggaaacgctt aagcagctgg cagttaagct aaaacaggct gaagcagagg 880261 aagcgggcta tcatcagctt ctcgaggaaa aacgaacgct tgaagcccgc cttgcagccg 880321 cggaaaccga attgaaagag acggcgggac atatccgaat gattgaggga gcgattgagc 880381 gaaagccgct gctaaatgaa aaagcgacac tcgaacaggt gattgcagaa tttccggaac 880441 acgcaggaca atttcctgct gacggactgc atcagctgga aaaatatgaa tcccatcttc 880501 acccgaaatc agcacagctt gaggcgcttc gggtgaagat ggcggagttg gacaaacaga 880561 ggcaaaagct tatccccgat aaagaactat tggcgaaaga aacgctgata caagagcttt 880621 cggcagcgtt tcatatgtac caatcctggg gagaacagct ggcagccatt caggcacagc 880681 tgcgccagac gtctgcgcag acagcggcag ggctggaaca gctcaataaa acggatgaaa 880741 atgagctcct gaatatgaac acctcatatg attatgaatg gcagcttcag caagcggtgc 880801 agcaatatgt acaggcaaga gacagaaaac ggcagcttga cgagacgttt gaacttgccc 880861 ggcaagagct ggaagacgcg gaaaaggccg ttcgtgccgc ttcgtccgcg attcttgaaa 880921 acagccaaag aaaagataaa gaagcagctc ttagagcata tgatgaaaca caggggcagc 880981 accaagagca agcgaagctc agagaacagc taacgttttt tgaaagacag caggctaaac 881041 agaaaaagac tgtcattgca gctggtatgt tgttcatcgt tctcttttct ctgctgcagc 881101 aatggattcc cgccataagt ttcggcgctg cacttattgt gtattggctt gtttcaggaa 881161 agtcgtcttc tcgaaacagc cgagagacaa gacagcccat gacggatatt tcaccagcag 881221 aagctgaaat gcttagagaa gcgttatggg aggatgaccg caataagcag caccttctca 881281 cacagcgtgc agcgctccag caaaaagagg cggcgtatga aagggtcatc cagcagtttg 881341 aacagtggga agccgaaatg gcgccgtcct ttacacaggt tgagcgtttt atgaatgagc 881401 tcggatttaa ggaagatcca tcatttttgc ttgatgcata cagcttaatg aaggatgtta 881461 aaaaagaagt gaagaaaaag catgagctga ccatagaagc aggcaggctg aaaaagcacc 881521 ggagaacatt cgaagaacgc gtcagtatgc ttcttcccgt gaatcagagt caggatatct 881581 ccatttcgga cgcccttcac acattgcgga aaaacattga acgtgaaaaa gaaattgaga 881641 agcaaaaaaa ggaaattgaa acagatattc attatacaaa ggaacagatg cttgaacttg 881701 agcaagaaat acagtatttc cacgcacaga ttgaacagtt atttgccgcg gctgctgcaa 881761 aagacagaga tgcgtttttt gccatagccg ccatcagcag gcaattgaag gatacggaga 881821 acaagcttca tcacgtaaac gcacagcttc aaggcgggta cccggaggaa cttgaactgg 881881 cggattccaa tacgctttct gaattgaaag ataagcaatt tgttgagaat gaaagaaaag 881941 agcggctgac tgaggagatc gagcagctcc gcagccaaat cgcactgctc tcagtcaaac 882001 aggaacaatt agaggcttcg ggaatggtct cagacctcaa gcttcaaacc gaaatgcaaa 882061 aagaacgtgt gaaagaaacg gctaaaaaat gggcctccat acaaatggtc aaacaggtga 882121 tcagaaacaa attggagcgg cataaaaaaa tcgagcttcc gcgccttctg gagacggcag 882181 gagaattttt ccgtcctctg actgacggaa actaccaaac catttatttt tccgaaacgg 882241 atgattcgat catggttatg catcgcgatg gcactgtcta tcatgcggaa gagctgtcac 882301 aagggacgtg tgaacagctg tatacagcga tccgctttgc tttggccgtt acgcgccagg 882361 gtgagtcaaa gcttccgttc cagcttgacg acagttttgt tcattttgat caggaaaggc 882421 tgaaacgtgt attacatgtt ctgtatgatt tatctgaagg cggtaggcag attttgtatt 882481 ttacatgcca tgagcacgta aaagatgcat ttcatagcag ccaaatcatc catttggtgt 882541 cataaaagag gttctatagc tgaaaatcgg tatgtgatat actggtatta tgtaagatac 882601 ggagggagct ttaatagaat ggctaaaggg attatgctac atgaggttgg cgaacaggtg 882661 gaccagtatc tattgattaa atcctcgacg aaagggattg caagcaatgg aaaaccgttt 882721 ctgacgctga tgctgcaaga ccagtcaggc gatattgaag cgaagctgtg ggatgccaag 882781 caaagtgatg aagtgaccta tgcgccgcag acgattgtca aggtcgtcgg cgatgttcac 882841 cattatcgcg gacgcaccca gctgaagcta agaaatatca gaccggtaag cgagcaagaa 882901 aacgtcaata ttgatgattt tttagaaacc gcgccgattc cgaaaaatga aatgatggat 882961 accatcactc aatatatatt tgaaatgaaa aatccgaata tccagcgaat cacaaggttt 883021 ttggttaaaa aacacgaagc tgagtttatg gattatccgg cggctacgaa aaaccaccat 883081 gagtttgtct caggtttggc gtatcatgtt gtctctatgc tgaacctggc gaaagcaata 883141 gcagatttat atccttctct tgatcgtgat ctgctttacg ccggtgttat cctgcatgat 883201 cttggaaaag tgaaggagct gtccggccct gtttccactt catatacggt tgaaggcaat 883261 ttgctcggcc atatttccat catggtgaca gagctttcaa aagcggctga ggagcttcaa 883321 atcgattctg aagaggtgtt aattcttcag catttgattt tgagtcacca cggcaaagca 883381 gaatggggca gcccgaaacc gcctatggtg aaagaagcgg aaattcttca ctatatagac 883441 aatctggatg caaaaatgaa tatgatggac agagcgcttg agcgcgtgaa gccgggcgag 883501 tatactgaac gtgtatttgc actggaaaac cgttcctttt ataaaccgac atttcataaa 883561 taacttaaaa aggactgatg ctgacatatt cagctcagtc ctttttgatg cgtctttccc 883621 gcacataact cgtctcattc ccgcatatgg ttaagaataa agaatctatg caaaggggga 883681 ggagcccgtg ttattttttc cgtggtgggt gtatctttgt attgtaggca tcattttcag 883741 cgcatataaa cttgtggcgg cagccaaaga ggaagaaaaa gtagaccagg cttttattga 883801 aaaagaagga cagatttata tggagaggat ggaaaaggag cgagaacgcc gcagttctca 883861 gcagcatgaa gaagaaaatc aaaaccattc catcgcataa aaaaagctgt gcggctcaat 883921 gagccgcaca gcttttttta ttatttagaa ttgcttgaag atgaagaagt gctgttgctt 883981 gttgaagatg tattaaatgt gtctttcaga tctttatctt ttacttcgat gtcagccttc 884041 ttcatgactt tttgaacagc ttcctgaaca gctgcgttgt catttaattt ttgttcaagc 884101 acttcagatt tcagttcttt tttcatatca tcatatttgc cgcgttcttc tgtcttttta 884161 atgatatggt agccgtattg cgttttgaca ggatcactga cttcacctgt ttttaatttg 884221 aatgcagctt tgctgaatgt ttcgtccatt tggccttctt ttgcgaacca gccaagatcc 884281 ccgccttttg aagcagagct gtctgttgag tattctttcg caaggtcttc aaacttctcg 884341 ccttttttca gctttttctc tacttcttca gctgtctttt tatcagcaac aaggatgtgg 884401 cttgcacgga ttttgccttt taagccttcc cagtactctt tgatatcggc gtctgttact 884461 ttgatgttat ctttagccgc tttttgtgtc agcaattcat attttacttg ttctttcagg 884521 taatctttgc catattgctt ttcgagggca gtatattgat cgccaagctg cgttttgtat 884581 tctttcagct tgttgtcaat ttctttatcc gaaactttat acttcttgtc caatactttt 884641 tcttgcacta gctgtgtcag tacgcttgcg ccagctgttt tcttcatgtt tgtgtaaagc 884701 tcgccttttg tgacatcgcc tgcgtctgtt tttgcgataa cttctttgtc gccgctgctg 884761 caagcactga gagcgaggat gcttgtagca gtgatagctg ctattgcgat tttcttcatt 884821 gttttcaaac actcctaatc attccaaatt aaattaccta tgcgtatcat aacatattgt 884881 ggctttctgt aaaaagattt taaataaagg gcattcgtct agtcaaactt ttgctgatga 884941 catacttata tattgatcaa gaaaaggagg tatgtaacat gagcggagga tactctaacg 885001 gattcgcgtt gctcgtagta ctgttcattt tgcttatcat cgtaggtgca gcttacatct 885061 actaagcagc ccgaggatcg cttgcaacat aagcgatcct ttattttcac tagcgcctaa 885121 tcgtttcaaa catgaattgc ataacatgta attggtaaat aaagcttatt acaggaggtg 885181 ctatttaaga tgggtgaagt atttgcaggc ggattcgctt tattggttgt gttatttatt 885241 ttattgatta tcatcggcgc ttcttggctg tactaatcaa cataaaaaag catagctgct 885301 taatcagcag ctatgctttc tttcgtattt acactgtaaa ggagatctcc acaaacgaag 885361 agatcagtaa aattaatata gatacattaa taaatcggaa taccttatct tgccgctctt 885421 caggaatctc tctgacaagg cataatgtat tggtgagcct gtttatgaaa tataaaataa 885481 acacggcagc cacgataaaa tagaataaaa tgatgggaga ttccccctct ctctgaactg 885541 tcccatatta cattaccaaa tatttattaa aaaagataga atgcaaattg aaaaatcgcc 885601 accagcacca gggtttgact acttttcaac aagaatatcc aagccgtcag cttcctgatc 885661 aataaaagcg gttttcggtg cttttatcag cttgagagcc agcaggaaat caggcagaca 885721 gtagccggcg tgaatgcccg agatcatgca aaaataatga gcgtgattcg gaaatgccag 885781 tgctgcgtaa aacaataccg gtgtaatcag caagaacggg ctgacgagtg aaatcagcat 885841 tgttgttttt ggtatacgtt tccatgtgcg catgcgcaat atgtaaaact ttttttctat 885901 ttttcttttt ttgcagatga ttggcaggac atggatgact ttatgtacaa ataaaataac 885961 gacgagcaaa ccgccgaata aagatacata ttcatcgctt aagcttgtgc caggccgcag 886021 cagctcaaaa gctaaaaagg tagatataaa aaccaaaatc ataaaacata cagcagttaa 886081 tattatgcga acggcgccat aatccttcat gagatttatg gtcttccagc aattcatcaa 886141 agtcatcctt ccatacatct tgaatagaat ctcaaaataa tttactcctc ccaagagaaa 886201 aaatcaatgc ttttttaaga aaaaatatca tccggcaggt atttttttga aacaagcaaa 886261 caaactgcga aatatggggt tagaactttc ttctcagtga attatcagct aaaataagat 886321 taaagataga aagaagtggt gtggatggat tcgatggatc atcgcattga gcgattagaa 886381 tattacatac aattattagt gaaaacagta gatatggaca ggtacccctt ctatgcgctt 886441 ctcattgata aagggctgag caaggaagaa ggggaagcgg ttatgaggat atgcgacgaa 886501 ttgtcggaag agctggcaac acaaaaagcg caaggatttg taacctttga taagctcctt 886561 gcgctttttg ccggacagct gaatgaaaaa ttagatgttc atgaaacaat ttttgccctg 886621 tatgagcagg ggctttatca agagctgatg gaagtcttta tcgacatcat gaagcatttt 886681 gattaactgt ttacaggttc gagctcttca gccggttcat ccgccgcact gtcctttgct 886741 tttttcttca attttccgtt tacgctttca aagtcattgt caatattggt gagtgacgtt 886801 tcgaaaattt ccataaaatc atcgccgtag atatggcgta tcatacacat catttctgcc 886861 acttcaggaa attttccgaa taaatgatat aaaggctgtg accctttaaa aacagcgttg 886921 cgtgtcggat caaattcctc aagcaagctc cagaatacct cggtaccttc ctcagtcaat 886981 tggacatatg tgttccgttt atcattcagc cgtttggaga accttaaata tccccgttct 887041 tccagctttt ttgaaaagtt gaatgcggtt gatacgtgca tgaccccgaa tttcgcgatt 887101 tcagaaatgg aagctccatt caattgatac gcaatccata aaatatgatg ctcattaata 887161 ttcaggtcat acggtttgag ccattgctgc caatccttct cgatcgattt ccaaagagcc 887221 ttgctaagct gagccatttt ctgggtgaaa accagagctt ctttcacatc atagggcggt 887281 tccactcgat tcattacgtc acctgcttct ctttttcttt ttctctatta tgccaataaa 887341 ataaagatta ataaagatga aaatgtaaga attttttaat aaattcacaa accattgcga 887401 cgaaagggtt tttcggccaa aaaaaatacg ggtccaattt tggcccgcat ttttttcttt 887461 tgaataggat attagttttg taaggttttc tccagctgtc tgattttctc ttcgatatcg 887521 gcaatttctt tttgcagatc ctgctggtga ggcttgatct cttcctgcca ttttttaatt 887581 gatgtttgga gctcgccgcc cacgtcttta ataacatccg tgctttcttt tgccgctttg 887641 atcagctggt cttttaatgc aagcccgtct gactttaagc gtttgattgt ttcttcaaaa 887701 gaatcataat tggttttcat tttttcacgc agctgctttc ctgaggaagg tgcagtaaga 887761 agaaccgctg ctcctccgat gatgccgcct acgaatagtc ctgttaatag agaacgtccg 887821 ctcgccatta caatcacccc gtctttttct tcaaaatagg attcattcag catttttcat 887881 ttttgttgaa agcctgaact tctatacata gcttgcttta ttttagcata ttttttaagt 887941 gaaaaggagg gagaaggttg tctgtctttt tgattgtatt atcctgcatc acccttgcct 888001 tcgcttcagg cgctgtttac tatatcaaac ttctcagcca ggctgcttct tatccgccca 888061 agagggttat ccggcagaaa gcgcttgttt gttcaaccgg aaccgccttt acactatgtc 888121 ttatcttttt cacaaaactc ctcgcttaaa acatgctgac atgctgcggg cgctctgttc 888181 aaaaaaacct ctcccggaag cggaagaggt tttgtgtgac aattatttag cagcttccat 888241 aaagcttgaa cgccttaaaa tggtttgcac aatcggataa ataatgatca ttgagattgt 888301 attcagcaca gcggccggca gaacaacagc cgcgaacaat gcggcgaaac cgcccggtaa 888361 accgacgatc aataaagctg acgatagaaa cacaattcct gataagatgg tcccgatcac 888421 tgtcagcaca gcggctgcac ctgttttccg gctctttctg aacaagagaa acagggagaa 888481 gaacagaaac gctgatacgg gtttatcaat gatgttaggg atctgtccgg ctggaaacgc 888541 ggttgtaagc gcggaaatga ttccggtcac gatcccgatg acgagtacat tttgcacccg 888601 cgggaacagc agaatgccca tgaacatcat gatcagcatc atatctggtt tcatgccgcc 888661 taaaaagggc ggaataatgg aatgaagcgc tgcgccgatt gcggcaaaca gagccataat 888721 gactaactct tttgttttca taactatgct ctcctctgct aagctttttg ccctccaata 888781 atatgctcat catttattgc gaaggcttta cagaatgtgt tatgcaaaca gtataccaaa 888841 cggacggttt gcatagccag actttttact cattttcctg ctggaatttc ttcatgaacg 888901 cagctaattt ttcacagtct tcgagagaga ccgcgttata aatagaagcg cggcagcctc 888961 ccaccgaacg gtgtccgcca aggccgatca tcttcgcatc ttttgctttc tgaacgaatg 889021 ttttcgttaa ttcgtcatcc cgaagcgtga atgtgacatt catgcgtgag cggctgtctt 889081 ttctggcatg tcctttatag aagccgttgc tttcatcaat acagctgtag agaacctgcg 889141 ctttttgttc attgcgctgt tcaacagctt ccacaccgcc gttttccttg agccattcca 889201 gaacgaggct cagcatataa atcgcaaatg tcggcggagt gttgtagagt gaatccgctt 889261 tgacatgcgt ggaatatttc aagatttttg ggacgttcgc attttcattt tgcagccagc 889321 tttttttcat gatgactaca gtcacgccgg aagggccgag gttcttttgg gcgcctccgt 889381 agatcacatc aaatttggac acatcgattt ttctgcttaa aatatcgctg gacatgtcgg 889441 ctacgagcgg aattggagaa ttcggaaact cctgccactg agtgccgaaa attgtattgt 889501 tggatgtgat atgtaaatat gcgccgtctt ttacatccgt aaggtcaacc tctggaatat 889561 aactgtaatt gtctgtttca cttgtagcgg tgatagacgt gttcccgaac agtttcgttt 889621 ctgccagtgc tttttcagac caagcgccgg tcatcacaaa atgtgcggtt ttttcaggtg 889681 ttaaaaagtt catcggaagc attgagaatt gaaggcttgc cccgccttga agaaacaaga 889741 tatcgtaatc ttccggaatg cccatcagtt cgattaagag gcttttcgct ttttggtgca 889801 ccgcttcata ctctttgctg cggtgggaaa gctccataac agacatgccg gattcgttaa 889861 aatcaataaa ttctttctgt gctttttgca gaacttccag tggcagcgct gcaggacctg 889921 cgttaaaatt cgttgtacgt tccattatga tctctccctg ttttccacgt taatgtataa 889981 aataatacaa ttatcctatc acaaaaattc agttttttga taaaaaatta gaattatcaa 890041 aagaaattga cggatgtttg cgaaatgttc acaaaataaa ataacctcat cttatgatga 890101 ggccaggcgt tttgcgatag aggaagagat gttctgcaga tcctccggtt tataatcatc 890161 agcatgcgtt ttccaaaccg ctccgaatcc atctcctttt ccgtagcgag ggataatatg 890221 catatggtag tggaacacag attgtccagc tttttcgccg ttattgttca gcgtatttaa 890281 gccgatcggt tcaaattcat cccggatagc gcgggcgatt tttggaacag catggaaata 890341 ttgttttgct aattcatctg taaattcata tacattctca atatgtgttt tcggaatgac 890401 aagcgtatgg ccttttgtca cttggctgat atcaagaaag gcaagtacat gttcatcttc 890461 atacaccttc gctgatggaa tgtcgccggc aataatttta caaaagatac aattctctgc 890521 acaatgcatg agggttcctc cttatgaaat tgtttagtat gtatacattc atcgtaccac 890581 agaaatgcag aaaatagaaa acaggatgaa cggcgagcgt tcaccctgaa tgcagaggaa 890641 gagcttatat gaagaaaatg tgttatgcct ttggtaagca cctcatttgt caataaaatg 890701 aagacttgtt taatgcctaa cgattcctgc gataaacacc tcatttgaca atttgcttca 890761 tacatgaaga attcatcaat tcagtgaaga gaaatggttt gagcattgga catgtttatt 890821 ttctatccaa ctgtttctaa gacgtctttg acaaacacct catttttcag ttgatatgct 890881 tttcctctac aacttttatg atgtccagaa ccctgtctct ttatgacagc aaattcatca 890941 tttgttaaaa gggaattgtt tcaaatcagg ccttgttttt ggtactatga agaaaaacac 891001 tataagggga gaaactatgt ctctgctatc ggtaaaagac ttgaccggcg gatatacaag 891061 gaatccggtt ttaaaaaacg tatcattcac ccttgaaccg aatcaaattg tcggcttaat 891121 cgggctgaat ggtgctggta aaagtacaac aatcagacac atcatcgggc tgatggaccc 891181 gcataaaggt tcaatcgaat taaacggtaa aacgtttgct gaggatccgg aaggctaccg 891241 ttcacaattt acctatatac ctgaaacacc tgttttatac gaagaattga cgctgatgga 891301 gcatcttgaa ctaacagcca tggcatatgg actgtcaaaa gaaacgatgg agaaaaggct 891361 gcctccgcta ctaaaggaat tccgaatgga aaagaggctg aagtggttcc cggcccattt 891421 ttctaaagga atgaagcaga aggttatgat tatgtgcgca tttttggcag agcctgcgct 891481 ctacattatt gatgagcctt ttctagggct tgatccgctt gccattaacg cgctgcttga 891541 acggatgaat gaagcgaaaa aaggcggggc gagcgtgctg atgtcaacac acattttggc 891601 aacggcagaa cgctattgcg attcgtttat tattttacat aacggcgagg tgcgggcgcg 891661 cggcacgctg tcagagctca gagagcagtt tggaatgaag gacgcggcgc tggacgattt 891721 gtatcttgag cttacaaagg aagacgctgg ccatgaataa tatgcttgat atttggcagt 891781 cgcggctgca ggagcatatc aaagaaacaa gaacatacat gaaatatatg ctcaacgatc 891841 acctcgtcat tgttttgatt ttttttctag cgggcgctgc aagctggtac agcaaatgga 891901 tacgggacat tcccgctcac tttccgtcct tttgggtgat ggccgtgctg ttttcgctcg 891961 tattgacaag ctcttatgtg cgaacgcttt tgaaggaggc tgaccttgtt ttcttattgc 892021 ctcttgaagc aaaaatggag ccttacttga agcaggcgtt tgtctacagc tatgtgtctc 892081 agctgtttcc gctgattgcg ctgagcatcg ttgcgatgcc gctttatttc gcagtcactc 892141 cgggagcttc gctcgtatcg tatgccgcgg tctttgtcca actgttgctg ctgaaagcgt 892201 ggaatcaggt aatggaatgg cgaacgactt tccaaaacga ccgcagcatg aaacggatgg 892261 acgtcatcat tcgctttgcg gcgaatacac tcgttcttta ttttgttttc caatctgttt 892321 atatgtatgc gcttctcgtc tatgtcatta tggctgttct ttatctgtat atgtcttccg 892381 cagcaaaacg gaaaacattt aaatgggaga gccatattga gtccgaattg agacgaaagc 892441 agcgtttcta tcggattgcc aacctgttta ctgatgtgcc gcatttgcga aagcaagcca 892501 aacgcagagc ttatctcgac tttttgctgc ggcttgtgcc gtttgaacag cgcaaaacat 892561 ttgcctatat gttcacccgc gcctttttgc gttcgagcga ttatttgggc attcttgtca 892621 gattaacgat cgttttcgcg ctgatcatta tgtatgtctc agccagcccg ctgattgccg 892681 cggttttgac tgtgtttgcc attttcatta cgggcattca gcttctgccg ctcttcggtc 892741 actttgacca tctggcgctt caagagctgt accctgtgca aaaagaaaca aagctgaaaa 892801 gctatttctc tctattaaaa actgcactta gtattcaagc gctgctgatg tctgttgcat 892861 ctgcctatgc agccggcttg accggttttc tgtacgcgct gatcggttct gccgttctga 892921 tttttgttgt tttgcctgct tatatgacga ccaggctgaa aaagcacgga aagctgtgaa 892981 ctgaaaagag gtaatcaaat gacagataat cagctgctga tgcaggaagc tttggaatgg 893041 aaaatgcatt ttttgcgaaa ggattccatg tttgaacgct tttcgaagcg tgtccagacg 893101 aaggtgaatg aacggattcc tgaaaaaatc catacggtcg tcaccgagag tgtgaaaaaa 893161 atggtagaag cgacaatggc cggctctaat atcatcacct ataaaaagga tacaagtgca 893221 ctgtcgctca gtgaaaaaaa cgaattggcg aaaaaaacga ttgtttctta tcaaaaagtg 893281 gcagctgctg agggagtcgg caccggagcg ggcggcattt ttttaagcat tgctgatttt 893341 ccgctgctgc tttcaattaa gatgaagtgt ttatttacct tgtcttccat ttacggcttt 893401 gatgtcaagg atgcacaaga aaggatattt ttgctgctcg tgtttcagct tgcgttttcg 893461 agtgatgatg gccgtaagtc gcttttttct gtcatcgaaa attgggagac ggagaaaaag 893521 agcatcgact ggagagtgtt ccagcaggaa tatcgcgatt atatcgacgt cgtgaagctt 893581 tttcagcttt tgccgggcgt aggagcggca gtcggcggaa ttgccaatta taagctgctt 893641 gctcagcttg gagaaacggc aagacatgtt tttcatctga ggatattaaa ggaaacagcc 893701 ggagaataaa cactccggct gtttttttat agctgatgat aggtgatcgc agcgccggca 893761 aggaccttgg ccgctgtcag catggctttt tcgttgatat caaatttcgg atggtggtgg 893821 gaatagactc gctctggctg ttcgggagcg gcgcctgtaa agaaaaaagt gcccttcacg 893881 ttttgtaagt aataagcaaa atcctcgccg cccatttgtg gttcaccgtc aatgacctgc 893941 tgaacgccct cggtattctt tgcggtgctc accaagtggt tcgtttctgc aggatggttc 894001 acaaccgctg gataaccctg ttcataggtg tactcatagg acgcgccgtg catgctgcat 894061 attcctttta caaccgcttc aatttctttc tccagaatgt cccggacatt ttcatcaaaa 894121 gaacgcgctg tgccgatgag tactgcttgg tctgcgatga cattaaacgg attgtcggcg 894181 atgaaggagc ctgtcgaaat gacggcggat tgaatcggat tgactttgcg gctgacaatg 894241 tgctgcaaag aggaaacgat ttgcgaaccg attaggacgg cgtctttagt atcatgcgga 894301 tgagcgccgt ggccgccctt tccgaagact ttaatcgtaa atcggtctgc cgccgccatt 894361 acggcgccgg ggcggcagag aatagttccg agcggctcag ttgcccaaag atgagtgccg 894421 aatatcacat ccgtgttttc gagacatccg tcatcaatca ttggctttgc gcctccagga 894481 taatattctt ctgcatgctg gtggatcatc acaaatgttc ccttcagttc atgtctgttt 894541 tggtgaagga ccttggccac tgcgagaaga gctgcggtgt ggccgtcgtg gccgcatgca 894601 tgcatgacac caggcacttt ggaggcgtaa gggacatctt tttcatcttg aatggggaga 894661 gcgtcaaagt cggccctcaa agcgactgta gggccgggtt cgcttccttc tatatttgct 894721 aaaacccctc taccgccaac gtttgtgcgg attgggactc ctaacgattc ataataggaa 894781 gcaataaatg cggcggtttt ttcttcttga aatgagagct caggatacat atgaaaatgg 894841 cgcctgatct caaccatttc ttcaaaacag ccgtcgagct gtttgtttat ctctttctgc 894901 agtgtggata tggacaaagc cgcttccccc ttttctatgc ttttccatga ttgtatagaa 894961 aaagtctgaa tatttcaact catgctgttt taaagcatca tcacagctgc gagggttgtc 895021 accaaaaggc caatcgcgac gggaatgaag ttttttctgg caagctcaaa aggatcaact 895081 ttgcaaatgg ccgcggcggg aatcaaagcc catgggacca gtgttcctcc gcccacccag 895141 atggcagaga tttgtccgag cgcggtcaga atagcgggat cggcatggag agcggacgaa 895201 aagagctttg cgatggagcc ggcgagagaa atgccagaaa atcctgagcc gtcaaggcct 895261 gttatggctc cagcggcagt taatgcagtg gcggcaagct cctttgacat aggcatcata 895321 tgggataaag caatgccaag atcgttgaca atgccgtggg aacctttagg gagtgaagtg 895381 cccagtatgc tttcatagcc tgagtcgcca agataaaaga aagcggcaat cgggatgacg 895441 gggccgaaaa ccttaaaacc gaacttaaat ccgtcaataa aatagccggt gattttttca 895501 agccctttat gcttatacac gaaaaaatga acggtaaaga ggatacaaat tgcagacccg 895561 ccaattaacg cggttgcatc atttccttgt aggttaaaca agagcatgca ggcgatatct 895621 gcaagaaagg caagcggaat caaaaaagcc agtatggacc gcaggcgttt tggcaagtac 895681 agcgagttgt cttgttcgcc ggaaagaacg ggggaaaaag aagtgggatg ctcctgtttt 895741 ttgcgttcgc gctgaatcat gataaaggca gcagttgttg ttgtcacacc cataatcagc 895801 acaagcggaa tactggccga gacgacatca ccgactggaa tgcctgctgc atccgcagtc 895861 agctttggcg ccgcctgaat gacaaagtct cctgacaggg caaaaccgtg tccgaataag 895921 ttcatggcca tggccgcggc aagaggcgtc aaaccggcac gtgcggctgc ggggagcagg 895981 acggcgccga tcaaagcgac acccggagaa ggccagaaga atagagaaat ggcgaacatc 896041 aggcctccaa tcagccaata ggcagtcaca ggccctctca caaggcttgc aaagggagaa 896101 atcatcgctt catttatccc tgtttttgtt aacaaatcac tcattgaaac gataaagcaa 896161 atgatgaaaa tcgtgggcag cagttcgccg gccgcataga taaagctgtg gaataaactg 896221 ctgacagaag ctgaaagtga atggctggcc catagcgata tgataaaaat gccgaataga 896281 gaaataaatg tcgtgtcttt tctcagcagc ataaatagga taattgcacc gataaaaaac 896341 acatacagaa catggacagg caaaatcccg acttccatca tcgatcactc cttccgctta 896401 cagattattc ataggcgggc ggaaggtgcc gggacagagg ggagggttat gatggaagat 896461 gaacattgat ctgtttcagc tgctcaatca gatgatgcct taatcctcta ttcgcttttt 896521 gcagatgttt tgggaagcat tcaggagaaa aaatgacgca cccttcagca agccagtttt 896581 ttctataggc gatgatgctt tccgatggct ctatatgagt tatcctcgtg ctgcatctcg 896641 tactcatcaa atccgaactg aaaaccgcag cacgggcaga tttcatgaga atgattgcct 896701 tcatgatcat atggcggttc agccaatcct taaacccgca gactgggcaa gtatgcttca 896761 ttttgctttc ctcccaataa aataagctgc cggacatgcc ggcagctatt cgacagcgaa 896821 atatgtggtg acataggaag gccgggagaa gatcgacgtt gtgtcaattc cggcagatgt 896881 atcgcgtttt ttgtgggctt ctttgtaaga accggactgc tgccagtctt gaaaggcgct 896941 ttccgtttcc cacaaggtca gaatgacata ggtgtcactg tcaagcggac ggagcactcg 897001 aattgcttca aagccaggct cgttttcgac ttttcccgct ctgtttttaa atctgttttc 897061 aaacagcgga cgcccttcct gagtaacggc aatattgttc aatactgcaa aaccgggatg 897121 tttgatctct ccgacttggt caatgacttc ataagcgtgt ggtgcctgga aaacggtatc 897181 tccgtttgtt tcatgaatta aaatggcgtt ttcctgcccc tgcatcaaaa ggatattttc 897241 tgagggatgc ttctgtacga tcgtttttaa aaaatcggct gtcccatatg taatataaac 897301 cttcatatca gccacctcct gcttgctagt atatcaaaac aatggtataa gtttctattg 897361 gcgagtgctt cgaacataat tccaaacaat ttttcccata ctacctttag aaaggcgagg 897421 tgagttcatg tttaagataa agaaaaagaa actttttata cctatcatta ttttagtgtt 897481 aactgctttt ctcgctttaa taggatatat ttcaattatt tttctcggcc attatgtcat 897541 agatgaaaaa aagcttattc ttcatgcttc ttcaaaaatt gttgatcaaa acggagatga 897601 ggttgcaagc ctgtatacag aaaatcgcga gccggtctcg atcaatgaga ttcctaagca 897661 ggtcagagaa gcgtttatcg ctgttgagga taaaaggttc tatgagcatc acggcattga 897721 tgcaaaatcc gtcggaaggg cagtgtaccg cgatatatta gcaggcggaa aggtggaagg 897781 cggaagcacg atcacccagc agcttgccaa aaatattttt ctgacacatg acaaaacatt 897841 tctaagaaaa acaaaagaag tgatcattgc gattaatctt gaacgggatt acagcaagga 897901 caagctgctt gaaatgtatt taaaccagct ttacttcgga cacggggttt acggcataca 897961 agcggcgtcc cactattatt ttaataaaga agtaaaagat ttgactgtat ctgaaggcgc 898021 tgttttggcc gctattccga aggcgccttc tacgtactct ccaattttgc accctgataa 898081 aaataaggag cggcgtgata caattctagg tatgatgaat gaccaaggct atatcagtgc 898141 gaaagaggct gtcaccgcac agggccggac gcttggactg catgtgaaga aacagtcgga 898201 aacaccttgg tttgacagct acattgacct tgtgatcaaa gaggcggaag acaagtattc 898261 catttccgga gagcagcttc ttcaaggcgg atacacgatc aaggtgccgc tcgattcgaa 898321 gctgcagaag acggcttacc aggtgatgaa agagggaagc tattatcccg gaacagatca 898381 gaatgccgag ggaagcgcgg tctttattaa taacaagaca ggcggtgtag aagcggccat 898441 cggcggaagg gattacacat ccaaaggata taaccgtgtc acagctgtcc gccagccggg 898501 ttccacattt aagccgcttg ctgtatacgg accggcgatg caggaaaaga aatttaagcc 898561 atattctcta ttgaaggatg agttgcagtc ctacggagat tatacgccga aaaactacga 898621 cagccggtat gagggcgaag tcactatgtc tgacgccatt acgtacagca aaaacgcgcc 898681 ggctgtctgg acgctgaatg agatcggcgt cgaaacaggg aaatcttatt tgaaagcaaa 898741 cggcattgat atccctgatg aaggccttgc tcttgctcta ggcggcttgg aaaaaggcgt 898801 ttcaccgctc cagcttgccg gcgcgtttca tacatttgcc gcgaatggaa cgtatactga 898861 acccttcttt atctcgagca taatagatga agacggagaa acaatagccg atcataaaga 898921 agaaggaaag cgggtattca gcaagcagac gtcttggaat atgacgagaa tgctgcagca 898981 ggtagtcaaa aagggaacgg ccacgtccgg cacctatcac ggcgacctgg cgggaaaaac 899041 aggttcaaca tcttatacag gcgtctccgg cgcgacaaag gacgcctggt ttgcaggcta 899101 tacgccgaaa ataaccgggg cagtctggat gggctatgac aaaacggatc aaaaccatta 899161 tttgaaagcc gggagctcat acccgacgcg gctgtttaag gatattttga cacaggcagg 899221 agaaaccggt catgtgttca caaagcctaa aaacgttaaa gaactggaaa gcccgattga 899281 gctgaagccg gtcaaaacac tcacagccga ttacacattt aaagcagcgg ggctctttac 899341 tattgaatta aagtgggacg ctcaagagga tgatcgggcc gtatacagaa tttatgtaaa 899401 caaggacggc gaggagacgc ttcttgattc ggttgaaggg aagggaagct atgaaattcc 899461 ttatgccaac ttattttcgg gcgcgtctta taaaattgtg ccttataata cacagacaaa 899521 aagagaaggg gaaggaaccg attacgttca gccaaaattg ttttcctctt aatggaattc 899581 ggcgattttt tgaactttga gctacatttc tataccattt gcctaaaaca aggtatagtg 899641 taataagtca agaaatacga acgtatggtt gccgtatgaa aggtggaaat cagatgagta 899701 aacgagaaac gtttaacgag acgtttttaa aagctgcgcg gggagaaaaa gcggatcaca 899761 cgcctgtgtg gtatatgagg caagcagggc gctcacagcc ggaataccgc aagctgaagg 899821 aaaagtacgg attgtttgag atcacacatc agcccgaact ttgtgcgtat gtcacaagac 899881 tgccggttga gcaatacgga gtcgatgctg caatccttta taaagatatc atgacgccgc 899941 tgccgtcaat cggtgtggat gttgaaatca aaaacgggat cggtcctgtg attgatcagc 900001 caatccggtc tctggcggac attgaaaaac tcggccagat tgatccggaa caggacgtgc 900061 cgtacgtgct tgagacgatt aaactgcttg tcaatgagca gctgaacgtc ccgctcatcg 900121 gtttctcagg tgcgcctttt acgcttgcaa gctatatgat cgaaggcggc ccgtcgaaaa 900181 actacaataa aacaaaagcc ttcatgtaca gcatgccaga tgcatggaat ctgctgatgt 900241 ccaagcttgc cgacatgatc atcgtgtacg tgaaagcgca gattgaggca ggcgcaaaag 900301 cgattcaaat ctttgattcg tgggtcggcg cattgaatca ggcagattac agaacataca 900361 tcaaacccgt gatgaaccgg atcttttcag agctcgcaaa ggagaatgtg ccgctgatca 900421 tgtttggcgt tggcgcaagc catcttgcag gtgattggca tgaccttcct ctcgatgttg 900481 tcgggcttga ctggagactc ggcattgatg aagccagatc aaaaggaatt actaaaacag 900541 tgcagggcaa cctggacccg tccattttgc ttgcgccatg ggaagtcatt gagcagaaaa 900601 cgaaggaaat acttgatcag ggtatggagt cagacggctt cattttcaat cttggccatg 900661 gggtatttcc tgatgtcagt cccgaggttt tgaaaaaact gacagcattt gtccatgaat 900721 attcacaaaa caaaaaaatg ggtcaatatt cctaagcata tcttttggta tcttaatgat 900781 atcctgtcaa aatgtttgta tcagatcatt aaagagggtg taaacagtga gtagaaagaa 900841 aatggggctt ctcgtgatgg cgtacggcac gccttataag gaagaagata ttgaacgtta 900901 ttatacacat atcagaagag gcagaaagcc tgaacctgaa atgcttcaag atttgaaaga 900961 cagatacgaa gcgattggcg gcatttcacc gcttgcccaa atcacagaac agcaggcgca 901021 taatctggaa cagcacttga atgaaattca ggatgagatt acgtttaaag cgtatatcgg 901081 actgaagcat atcgagccgt ttattgaaga cgccgtagca gagatgcata aggatggcat 901141 tacagaagca gtcagcatcg tgctggcgcc gcatttctcc acgttcagcg ttcagtccta 901201 caacaaacgc gccaaagaag aggctgaaaa actcggcggc ttaacgatta cgtcagttga 901261 aagctggtac gatgaaccga agttcgtgac atattgggtt gaccgagtga aggaaacata 901321 tgcgtcaatg cctgaggatg aaagagaaaa cgcaatgctc atcgtatccg cacacagcct 901381 gccggaaaaa atcaaagaat ttggagaccc gtacccggac cagcttcatg aatcggcgaa 901441 attaattgct gaaggcgcag gcgtttccga atatgctgtc ggctggcaaa gtgaagggaa 901501 cacgcctgat ccttggctcg gacccgatgt tcaggattta acacgtgatt tattcgaaca 901561 aaaaggctat caagcatttg tatatgttcc tgttgggttt gtcgcggatc acttagaagt 901621 gctttatgat aatgattatg aatgcaaagt ggttactgac gatatcggcg caagctatta 901681 ccggccggaa atgccaaatg ccaagcctga atttattgat gctttggcaa cagtcgtatt 901741 aaaaaaatta ggacgttaaa gaaggcgatg aacatgagtg acggcaaaaa acatgtagtc 901801 atcatcggcg gcggcattac cggtttagcc gccgccttct atatggaaaa agaaatcaaa 901861 gaaaagaatc tgccgcttga gctgacactt gttgaggcaa gtccgagagt cggcgggaaa 901921 atccagactg tcaagaaaga cggctatatc atcgaaagag ggccagactc atttctggaa 901981 cgaaagaaaa gcgccccgca gcttgttaaa gacttaggtc ttgagcattt gcttgtcaac 902041 aatgcgaccg ggcaatccta tgtgcttgta aaccgcaccc tgcatccaat gccgaagggc 902101 gctgtaatgg ggataccgac aaaaattgcg ccgtttgttt ctacgggtct gttttccttg 902161 tccgggaagg cgagagctgc tatggatttc atcctgcctg caagcaaaac aaaggatgat 902221 cagtcattgg gagaattctt ccgcagacgt gtcggagatg aagtggtcga gaacttaatc 902281 gagccgctac tatcagggat ctacgcaggc gacattgaca agctcagcct gatgtcgaca 902341 tttccgcaat tttatcagac ggaacaaaag catagaagcc tgattctcgg catgaaaaaa 902401 acaaggcctc aaggctcagg ccagcagctg acggcaaaaa aacaagggca gttccaaact 902461 ctgtcaaccg gtttgcagac ccttgtagaa gagatcgaaa agcagttaaa gctgacgaag 902521 gtgtataaag gcacaaaagt gaccaaactt agccatagcg gctcttgcta ttcgctcgaa 902581 ctggataacg gcgtcacact tgatgctgat tcagtaattg tgactgctcc gcataaagcg 902641 gctgcgggaa tgctttctga gcttcctgcc atttctcatt tgaaaaatat gcactccaca 902701 tccgtggcaa acgtcgcttt aggtttccct gaaggctccg tccaaatgga gcatgagggc 902761 acgggttttg tcatttcaag aaacagtgac tttgcgatca cagcctgtac gtggacgaat 902821 aaaaaatggc cgcacgcagc gccggaaggc aaaacgctgc ttcgggcata tgtcggaaaa 902881 gccggagacg aatccattgt cgatctatca gataatgaca ttatcaacat tgtgttagaa 902941 gacttaaaga aagtcatgaa cataaacggc gagccggaaa tgacatgtgt aacccgatgg 903001 catgaaagca tgccgcagta ccatgtcggc cataagcagc gtatcaagga gctgcgtgaa 903061 gcacttgcat ctgcgtatcc gggtgtttat atgacaggcg cttctttcga aggtgtcggc 903121 attcccgact gcattgatca aggaaaagct gccgtgtctg acgcgcttac ctatttattc 903181 agctaaaacc tccgctttat cgcggaggtt tttttgatgt gcaatggcaa tattgtgtaa 903241 aaaatgattg aattgaacag caggttatga tacatttgca tatgtactta atgactaaaa 903301 tgttcaaacg gtcagtttcg aggtgaatac aatgtcaata gatcgaaaaa agctcatttt 903361 ggaggcggct acaaagtctt tcacgcagtt cgggtataaa gcgacgacaa tggatcttgt 903421 cgcaaaactt gcgaacgtgg ggaagggaac catttatact tttttcaaaa acaaagaaga 903481 gctgtttgac gagattttca ctactttatt aaaggaaatg aagcaaaaag cggatgaagc 903541 gatggagccg agccttccgt tccatgaaaa tgtgcacaga gcgctgtttg ccattctgga 903601 gttcaggaaa acacatcagc tgacgattaa aattttccaa gagaatgccg agattggtac 903661 aatggcagtt caggaagtga tccagaaaat ggagcgatcc atcctgtctt atatcaaaag 903721 caagattgaa gacgggatca aaagcggcgc aatcaagccg tgcgaccctg agctgacagc 903781 ctttgtgatg ctgaagcttt atatcgcgct catttttgac tgggaaaaac aacacccccc 903841 gcttgataaa gagacaattg cgggactgct tgaattgtat gttgtcaaag gattgtcagc 903901 gaactagata atcctttctc tttgcaagaa aatgaccatt ttttatgatg agtcagtttt 903961 agaatggagg catcaggatg aacacaatac gaagtcagtg gaaagacatc gtaacaagta 904021 aaaaattatt gattcccatc atcgccattt tgtttgtccc gcttatttac agcggcgtat 904081 tcttaaaggc ttattgggac ccgtacggca cagttgacca gctgcctgtc gttgtcgtca 904141 accaagacaa gggagcaacg tatgaaggag aaaaacttca aatcggtgat gatctggtca 904201 aagaattaaa ggataataac aactttgatt ggcatttttc caatgatctc gaccaatcgt 904261 taaaggactt attgaatcaa aaatattatt tagttgtcga gattcctgag gatttttcta 904321 agaatgccag cactgtatta gacaaaaatc cgaaaaaatt ggatctgaaa taccatacaa 904381 atgcaggttc taactatgta ggggcaacga tcggcgaaaa agcgattgat aaactgaaag 904441 cctctgtttc aaaagaagtg accgagcaat atacgaaagt tatttttgat aactttaaag 904501 atatcgcaaa aggtttgagc gacgcgagca gcggcgcgaa aaaaattgat gacggcacaa 904561 aggatgcgaa aaacggaagc gcccagctga aagaaaatct ggcgaagctg aaggaaagca 904621 ccgctaccat cagtgacaaa acagcgcagc ttgcagatgg agcggctcag gtgacgagcg 904681 gcatccaatc acttgacagc tcgctcggta aattccagga cagcagcaac cagatttatg 904741 ataaatctag tcagcttgca gcaggatcag gcgagctgac aagcaagatg aatgaacttc 904801 ttgccggact tcaaaatgtg cagaagggta cgcctaatct tactaacggg ttggatcagc 904861 tcaacagtaa agtccaagaa ggttctgaga aagcggcaaa agcggaaaag atcattaatg 904921 cgctcgattt aacgaagctt gaaactgctg taaacaatct ggaaaagtca gaaactgcga 904981 tgaaggaatt caaaaaacag ctgactgact ttgaaaacag tttgaaaaac cgtgatcagg 905041 catttaaaaa tgtcatcaat tcgagtgact tcttaacagc ggagcaaaaa agccagctga 905101 ttaattctgt tgagaaaaag cttccgcaag ttgatgcgcc tgattttgat caaatattaa 905161 gccagctacc tacagctgat cagctgcctg acatcgcaac gataaaaagc tctcttgaag 905221 acgtgaaagc gcaggtggcg caggtgaaag ccatgccgga agctacatct aagctttata 905281 acggcgcaaa aacaatccaa gatgcgattg acagattaac tgagggagct gataagatat 905341 acaacggttc tcagaagctg acagatggcc aaactaaact gacagcgggc atcggtgaat 905401 ataataagca gttcgcaaaa gcaaaagcgg gctcagagca attggtgaca ggaagcagcc 905461 aagtatccgg cggattgttt aagctgttag acgggtctaa acaggtccaa agcggatcat 905521 caaaacttgc agacggatct gcatcacttg atacaggttt aggcaagcta ttggacggca 905581 caggagagct gtctagtaag ctgaaggatg cggctgacca aacaggagat atcgatgctg 905641 atgatcaaac atacggcatg tttgcggatc cggttaaaac caaagatgat gccattcatt 905701 ccgttcctaa ctatggaaca gggctgacac cttatatcct gtcaatgggc ttgtatgtcg 905761 gcggcatcat gctgacggtt gtcttcccgc tgaaggaagc gtcaggacgt ccgagaaacg 905821 gttttgagtg gttcttcagc aaattcaatg tcatgatgct tgtaggaatc attcaatcat 905881 tgattgtggc gacggttctt ctattgggaa ttggtcttga ggtagagagc acgtggagat 905941 tttacgtgtt tacgatcatt acgagtctcg ctttcctggc gataattcaa tttttggcta 906001 caacgatggg caacccgggg cgatttatcg cagtcattat tttagtgctg cagctgggag 906061 cgagcggagg aaccttcccg ctggaattgc ttccgaattt ctatcaggtc atccacggcg 906121 cattgccgat gacctacagc attaacggat tcagagcagt catttcaaac ggtgactttg 906181 gctacatgtg gcagatggcc ggcgtcttaa tcggcattgc cctcgtcatg attgcactaa 906241 gcattactta ctttacaatg ttaagccgga aggaagaaac atcagaagaa cagccggctt 906301 cataaagaaa aagaacttgt ttccttggaa acaagttctt tttttgttac atcccccatt 906361 taataagcaa tcctgtatag gttaatccgc cgccaaaccc gaaaagcaaa acgatttgat 906421 cttttttcag cttcccggct ttcactgcga gatcgagcgc caaaacaatt gaaaccgaag 906481 acgtgtttcc gtagtgctca acactagtga gcgttttttc aatcgggaac ggtgtttttt 906541 cacaaattga ctcgatcatg cgcaagttgg cgctgtgagg aacaaaccaa tcgagatcat 906601 cggagctgag tcctgcttta tgtaaaagcc gttcaaattc gccagggacg gttcttgcgg 906661 cccatttata tacctcgcgt ccgttttgca ccatttttcc ggaaccgaca agctgcacac 906721 cgtttatttc atttcgcagt ccggcacgat acaaaatatc gccgccgttc ccgcttgttc 906781 cttgtacaga cgcaagaaat cccggcgtct cttcatctcg ttctactaac agcgcacccg 906841 cggcatcgcc gaacagtacg catgtcgttc gatcggtata atcggttacc tttgataacg 906901 tctctccggc gatgacgaga attttttgat gaaggccaga tgtgatcaat ccatttgcca 906961 aatggaggcc gtatgtcagc ccggcgcatg tcgcattaat atccagcgcg ccggtgcttt 907021 cccagccgaa atattcctgt acgcggcatg ccgtactcgg aaaggcgtaa tcggatgtgg 907081 ttgtggcaac gaggatcata tcgacatcat caagcgttcc tttataacgg ctcttgagat 907141 tcttcaccgc ttctatgcat aaatcagagg taaattgatg ttcatccgca atccggcgtt 907201 ctctcattcc tgtgcgctga acgatccatt catcagaggt atcaacgatc ttttctaaat 907261 ctgcattggt taaacgtctg ctcggcgcat aggtgccgat agctgtaatt tttgcttttg 907321 acatatgaat cactccttat ggtcagatta taacactaga tattagtatc tggtactaaa 907381 aagaaggttt ttttacaaaa aaagagaagt gtagatagga atctatgaaa aagaaaaagg 907441 aggctgaaaa atggtcagtc aagaagcagt agtctttttg gcattatccg gggctattgc 907501 gtttctgttg ccaatcgggc tgattgtatg gtttaagcga aagtatggtg cctcgcttaa 907561 agtgtttttt attggcgctc tcacgttttt tgtcttcgct cagctgctgg aaggcggcgt 907621 tcatgtttat gtactgcaag tgaatgaaat gacgaaagaa gcgatgcagc atccattatg 907681 gtatggcatt tacggctgct tgatggccgg catttttgag gagtgcggaa ggtatttgat 907741 gatgcgattt tttatgaagc gccatcatac ttgggcagat ggtctggctt tcggggcagg 907801 ccatggcggg cttgaagcca tcctgattac aggcttgtcc tctatctcac ttattgtata 907861 cgcatttgca atcaatagcg ggacgtttga acagcttttg gtcaatggcg acgtcaaaca 907921 ggcgcttttg ccgatacagg agcagctgct gcatactcct tcgtatgaat ggatgctggg 907981 cggaatagaa agaatcagtg ccattgccgt ccagattggt ctgtctctgc ttgttttgta 908041 cgcggttaaa aaccgccggc cgctgttttt gctgtattct attcttttac atgcactgtt 908101 taatgtcccg gcggttttat atcaaagagg aatcatagag catgctgcag ctgttgaaat 908161 cattgttgct cttatagcgg ctttatcagt ttattggatt gtaaaagcaa aaagggtgtt 908221 tcaataaaag gtccaagcag cagcaatgcc cgcttggaaa aatgtgaatg gaaatattca 908281 ttaagcatgg gtcatcagaa tatttctgat tcagtcttta gcaatgacag caagaatgtc 908341 tgtgtttttt acaagagaaa caatggtgtt tctttttctt cttctcgcaa gggtcatggc 908401 attctttctt tttcttgcaa tggtcgtgga aatctttatc gaaccactcg tcaaagaacc 908461 aaaaatcatc gaaccaatcg tgacaacgac atttctgttc atgtgaatga cgacagcaca 908521 tagaaatccc tcctcttccc atgctctcta cagcatatga gagattgata ggaaaagatt 908581 ggacgggtcc ctcgggaaaa gagtatattt taagtagaaa ataaaaggag gaatgcccta 908641 tgacgtccgt acgtaaaacg atggagctca ttaaagaact tgtatcgatc ccaagcccga 908701 caggaaatac atatgaggtg atcaattata ttgaaagcct tttaaaagaa tggaaggtag 908761 aaacggttcg gaaccacaag ggcggcttaa ttgcaacgct tccaggacgc gacacatccc 908821 ggcatcgcat gctgacagcg cacgttgaca ccctcggcgc tatggtgaag gaaattaaag 908881 cggacggccg gctgaaaatc gacttaatcg gcgggttccg ctacaactcg attgaggggg 908941 agtattgcca aattgaaacc gcctcgggaa aaatgtacac aggcacaatc ttaatgcatc 909001 aaacgtctgt gcacgtatac aaagacgcgg gaaaggctga gcggaatcaa gagaatatgg 909061 agatccgcct agatgaacct gttcactgcc ggaaagatac ggaggagctt ggcattggcg 909121 tcggagactt tgtgtcgttt gatccacgtg tcgagatcac atcaagcgga tttattaaat 909181 cgcgccattt ggatgacaaa gcaagcgtcg ccttattgct ccgcttaatt catgaaattc 909241 aaacagaaga cattgagctg ccgtatacaa cccattttct tatttccaat aatgaagaaa 909301 tcggttacgg cgggaattcg aatattcctc ctgaaacagt tgaatatttg gcggttgata 909361 tgggcgctat cggtgacggg caggcgacgg atgaatattc agtatcaatc tgtgtgaagg 909421 atgcgagcgg gccgtatcat tatcagctca gaaagcattt agttcaatta gccgagaagc 909481 atcatattga ctataagctt gatatatatc cgtactacgg gtctgatgcg tcagcagcga 909541 tcaaatccgg gcatgatatt gtgcatggcc tcatagggcc gggaattgac gcttcccatg 909601 catttgaacg cacccataaa tcatctcttc gccataccgc taagcttctg tattactatg 909661 tacagtcacc aatggtataa gggggaggac caatgaagat ttataagctg aaaagcacat 909721 tcggttggga aggtgatgac gggttgggag aacagctgat tcagcagatc cttgccggag 909781 aaaaaagcgc cacgtgcgcg ccgaaatcat tgtattcaaa agatgaattg agggacgttt 909841 atcaaacagc gggtcagctt gttaccgttt atgataaaca tgacaatcca agatgcaata 909901 taaaagtaac agatgtcttt gaaaccacct ttggtgcgcc tgatatgagg ttagtcaaag 909961 gagagggcaa tggagaccga attgaggagt ttcaagagga tcatcggatg gcatgggcgg 910021 aactgatcaa aagcggtgaa ctggagctga atgaggatac tgttttgatt acagagttgt 910081 ttgtgcttgt taaagattaa aaaagcctgc ggggcaagaa ccccgcaggc ttttcattaa 910141 ccagaaatgg ttgcgttttg ttctgttttc gattgggaca taacagtttc tgctttcgca 910201 ggattaaaca tgccttccca tttagacatc acaacggcag caagcgcgtt accagtcagg 910261 ttgacaactg tacgtgccat atccatgatg cggtctacgc cggcaataaa ggcaagtcct 910321 tcagccggaa cgccgatggt gccaagcgtt gcaagcaaga caacaaaaga agtaccaggt 910381 acggcagcca tccctttgga tgtcaccatt aagacgagca caagcgtaat ttggtgccaa 910441 atcgtcaaat caatgccata tacctgtgct aaaaagagtg cggcaataga ttgatagaga 910501 acggaaccgt ctaagttaaa cgtgtaaccg atcggaatga caaatgaaac aatgcctttt 910561 ggacatccga ttttctccat tttttccatg atacgcggaa gaaccgtttc agagctggac 910621 gtactgaacg ccagtaagat ttcgtccttc atgtaagcaa ggaacttgaa gatgctgatg 910681 ccggcaattt ttgcgacaat cccgaaaata acaattaaga agaaagcaag cgcgacataa 910741 accaatccga cgagctttcc gagagagata agagaaccga gtccgaattt agacacagtc 910801 actccgataa gagcgaaaac gccgaatggc gccactttca tcacaaggtt tacaacgtgg 910861 aacatggcat gggatacacc ttcaaaaaag gctaatacag gcttgcctct ttcaccgatc 910921 gcggaaatac ccaatgcaaa tagtactgta aagcagatga tggctagaag atccccttcg 910981 accaatgact ggaagaagtt tgtcggcaca atatggagga acgtttccgc cactgattta 911041 ttactttgtt ctttttcagt ttcaacatat tgactgatgt ccgatttttg agcttcgtgt 911101 atattaactc ctgtacccgg atggaagatg tttgcaaggg ctagtccgag aataatggca 911161 aaagtcgtga tgatctcgaa gtacagaatc gttctgaagc ctaatttacc gacttgcttt 911221 ccatttcctg caccggctac accgatgatt aagctggaga caacaatagg aatcactatc 911281 attttgatta agcgtaaaaa gagatccccg attggctgca ggtaagtagg caatgctggg 911341 ttgccatacc aaatgacgcc aacaatgaca cctagaataa gtccaacgaa tatttgtgtg 911401 gctaatccaa acttaattct tttcatagat tacctcccaa aaaacaaagt atcaacatat 911461 atcatgaata gacatatatt taatctcact attagatcaa attataatag ataagaaatc 911521 aattcgtcta tagtaaatta tatttcgaaa ataaagaata ttcaatgaca ttatgataat 911581 caccagaatt atctaaaaac aggtgagctt tgacctaacc tgactattat ttcaaaatta 911641 agagatatgt gaaaaaataa gaaaatccca cgcgtaaggc gcgggatttt cgctcattac 911701 aaatcgttta cttttataca gtcattgcag atattaccat aacactcatg ctgctcttct 911761 atcttttttc cgcattccgc acactttttc gaaggcaggt ttctaaaaaa ttctgtgatt 911821 ttccccagca taaccaatcc ctctttcccc tttgtagtga tttcattgta atataacaga 911881 ttacaaaaat caataactgt tttgatacaa tgtttaaaac atgctttttt caagaaaaat 911941 gggtatattg aaggaggacc aatttttttg aaaagatagg aggacattat gaaagttaca 912001 gttatcggat gctatggcgg ttttccggcc gcaaatgaag cgacgtcagg ctatttgttt 912061 cagtcaggtg attactctct gcttgttgat tgcggcagtg ccgtattgtc taagctgttc 912121 ggatatgtgc cggcggaaaa gctggatgcg gtcgttctgt ctcattatca ccatgaccat 912181 atcgctgata tcggaccgct gcaatttgcc aagcaagtcg gttcgtttct cggcaaagga 912241 gagcatacgc ttccgattta cggacatgat gctgatatag aacagtttca aaagcttaca 912301 tataaaacac atacaaaagg gatcgcctat cagccggatc agccgctgac tgccggtccg 912361 tttacgatca cctttttaaa aacgattcac ccggtgacgt gctatgccat gcggattact 912421 gacggcagcc acactgtcgt ttatactgct gattccagct atcaggattc atttataccg 912481 ttttcgaaag atgctgattt attgatctca gaatgcaatt tttatgccga tcaagacgga 912541 acaagtgcag gccatatgaa cagcctggaa gctgggcgca ttgcaaaaga agccggagcg 912601 ggagaactgc tgctgacaca tttgccgcat tttggcgtgc atgacaacct tcgcaaagaa 912661 gcgaaaaccg tttttaacgg agaagtgaat attgcgaaat caggttttgt gtgggaagga 912721 taaaggagga gcaccatgtt atttatagac aatcaaaata tcaatgatcc gcggatcaat 912781 cttgctatcg aggagtactg tgtaaagcat ttagaccctg aacagcaata tttgctcttt 912841 tatgtgaatc aaccgtctat tatcattggg aaaaaccaaa atacaataga agaaatcaat 912901 acaaaatatg ttgaggaaaa cgggattatc gtcgtccgcc gtttatcagg cgggggcgct 912961 gtgtaccatg atctggggaa cttgaacttc agctttatta ccaaggatga cggggacagc 913021 tttcataact ttaaaaaatt cactgagcca gtgattcagg cgttacatca gcttggggtt 913081 gaagccgaat taagcggccg gaacgacatt gtagtagatg gccggaaaat atccggaaac 913141 gctcagtttg caacgaaagg ccgtattttc agccacggca ccctcatgtt tgattcagcc 913201 attgatcatg ttgtatcagc attaaaggtg aaaaaggata aaattgaatc aaaaggcatc 913261 aaatcgatca gaagccgagt ggcaaacatc agtgagtttc tcgatgataa aatgaccacc 913321 gaagaattcc gcagccattt gcttcgccat atttttaaca caaacgacgt tggaaacgtg 913381 ccggagtata agctgacgga aaaagattgg gagaccattc atcaaatttc gaaagagcgc 913441 tatcagaatt gggattggaa ctacggccgc tcaccaaaat ttaaccttaa tcattcgaag 913501 cgttatccgg ttggatcgat cgatttgcac ctggaagtca agaaaggcaa aatcgaggac 913561 tgcaaaatct tcggagattt cttcggtgtc ggtgatgtat ctgaaattga aaacctgctg 913621 gtcggaaaac aatacgaacg cagcgtcatc gctgatgtgc tcgaaggtgt gaatctcaag 913681 cattactttg ggaacattac gaaagaggat ttccttgatc tgatttacta aggcaaaaca 913741 catcgtttga aagagcggtt gtgtttttga aataatggag gcaggaggga ttcacatgaa 913801 agtgttttta atcggagcga acggacaaat cgggcaaaga ctcgtctctt tattccaaga 913861 taatcctgat cattccatca gagcgatggt cagaaaagaa gaacagaaag cgtctcttga 913921 agctgccggt gcagaagctg tgcttgcgaa tctggagggc agcccggaag aaatcgccgc 913981 tgcggcaaaa ggttgtgacg cgatcatttt cacagccggt tccggcggca gcacaggcta 914041 tgataaaacg ctgctggtgg atcttgatgg agcggcaaaa gccattgaag ctgcggccat 914101 tgccggaatc aaacggttta ttatggtcag cgccctgcaa gcccataacc gtgaaaattg 914161 gaatgaggca ctcaagcctt attatgtggc caagcattat gctgataaaa ttctggaagc 914221 gagcggttta acctatacga ttatccgtcc gggaggcctt cgcaatgagc ctggaacggg 914281 aactgtttca gcagcgaagg atctggagcg gggatttatt tcccgtgatg acgttgcaaa 914341 aacggtcatt gcctctttag atgagaagaa tacggaaaat cgggcctttg atctgacaga 914401 aggagatacg ccgattgccg aagcattgaa gaaactatga cagtactgac actcagggct 914461 ttttgctctt gagtgttttt ttctgtttct ctataatgga gaagaaagct tggcttcaat 914521 aatgaatgac tattcattca cttaaggggt gggagaatga atcttgtttc aaaattggaa 914581 gaaacagcat ctgagaagcc cgacagcatc gcatgcaggt ttaaagatca catgatgacg 914641 tatcaagagc tgaatgaata tattcagcga tttgcggacg gccttcagga agccggtatg 914701 gagaaagggg accatttagc tttgctgctt ggcaattcgc ctgattttat catcgcgttt 914761 tttggcgctt taaaagctgg gatcgtagtt gttcccatca atccgttgta cacgccgaca 914821 gaaattggtt atatgctgac aaatggcgat gtaaaggcaa tcgtgggcgt tagccagctt 914881 ttgccgcttt atgagagcat gcatgaatcg ctgccaaagg ttgagctcgt cattttatgc 914941 cagacggggg aggccgagcc ggaagctgcg gacccagagg tcaggatgaa aatgacaacg 915001 tttgcaaaaa tattgcggcc gacatctgcc gctaaacaaa accaagaacc tgtacctgat 915061 gataccgcgg ttattttata tacgtcagga acgactggaa aaccgaaagg cgcgatgctg 915121 acacatcaga atttgtacag caatgccaac gatgtcgcag gctatttggg aatggatgag 915181 agggacaatg tggtctgcgc tcttcccatg tttcacgtgt tttgtttaac cgtctgtatg 915241 aatgcaccgc tgatgagcgg cgcaactgta ttgattgagc ctcaattcag tccggcatct 915301 gtttttaagc ttgttaagca gcagcaggcg accatttttg ccggtgtgcc tacaatgtat 915361 aactacttgt ttcagcatga aaacggaaag aaagatgatt tttcttcgat ccggctgtgc 915421 atttcgggag gcgcgtccat gccagtcgcg ttgctgacgg cgtttgaaga aaaattcggt 915481 gttaccattt tggaaggcta cgggctctcg gaagcatcac ccgtcacgtg ctttaacccg 915541 tttgacaggg gcagaaagcc gggctccatc gggacaagta tcttacatgt cgaaaacaag 915601 gtcgtagatc cgctcggacg cgagctgccc gctcaccagg tcggcgaatt gatcgtgaaa 915661 ggccccaatg tgatgaaggg ctattataaa atgccgatgg aaacagagca tgcattaaaa 915721 gacgggtggc tttatacggg ggacttggca agacgggatg aggacggcta tttttacatt 915781 gttgaccgga aaaaagacat gatcattgta ggaggataca atgtgtatcc gcgggaggtg 915841 gaggaggtgc tgtacagcca tccggacgtc aaggaggcgg ttgtcatcgg cgtgccggac 915901 ccccaaagcg gggaagcggt aaagggatat gtggtgccga aacgctctgg ggtaacagag 915961 gaggacatca tgcagcactg cgaaaagcat ctggcaaaat acaagcggcc tgccgccatt 916021 acgtttcttg acgatattcc gaaaaatgcg acggggaaaa tgctcagacg ggcactgaga 916081 gatattttgc cccaataaaa tgaaaaagcg aagcggttag cttcgctttt tcattttcaa 916141 tcctttgctt cttttttaat aatatttagc agcgccgccg atgacaacaa agcgaagcag 916201 ctgatcaaca aggatgtgct gaagaaaatt gacggctaca catctgtcgg cactcgctca 916261 cagccaagca tggaaaaaat cgcttcatta aaacccgatt taattattgc tgacacgacc 916321 cggcataaga aggtgtacga tcagctgaaa aaaatagcgc cgacgattgc acttaataat 916381 ttaaatgctg attatcagga tacaattgac gcttcgctta cgattgcaaa agcagtcggc 916441 aaggagaagg aaatggagaa aaagctgacg gcgcatgaag aaaagcttag cgagacaaag 916501 cagaaaatca gcgcgaacag ccagtccgtg cttttgatcg gaaatacaaa tgataccatt 916561 atggccaggg atgaaaactt ctttacatcg agacttttaa cacaggtcgg ctaccgatat 916621 gcaatcagta cgtcaggcaa tagcgattca agcaatggcg gcgactctgt gaatatgaaa 916681 atgacactgg agcagctgct gaaaacagat ccggatgtga tcatcctgat gacaggaaaa 916741 acagatgacc tcgacgccga cggtaaacgc ccgatcgaaa agaatgtcct ttggaaaaaa 916801 ctgaaggcag tgaaaaacgg gcatgtatac cacgtggatc gtgcggtgtg gtctctgcgc 916861 cgcagtgtag acggggcgaa tgccattttg gacgagcttc aaaaagagat gccggctgct 916921 aagaaataaa agaaaagaca ggcaaacgcc tgtctttttc ttatttgata aagccggata 916981 agtggctgtt gatattatag tcttttatcc gccatttttc ttctgcaaat tcaatgttgc 917041 tgaggcaggc gttgacgaga cgggtgcttt gaagctccgg gtcaccgccg gatatttctg 917101 tcagcagggc gtgaattgcc gcaccgtgcg ccacgatcag caccttcttg tttggatacg 917161 cctgattcac ttttgccaaa ccgcccatca gcctgtcagt gagttcttct aaggtttcca 917221 tattcggata gatgttatct ggatagcgct ttgtccgttc ctccagcggc atgccctccg 917281 cgtcgccgta atcgcgttcc ttaaaatcat ccatctcgac tatcggaaga tgcagatatt 917341 cattaataat ttccgcggtt cttttcgctc ttttcagcgg gctcgtcaca ataatatccc 917401 aagaaaagtc ctttacatat tctccggttt ctcttgcttg gcgttcacct gttgcgttta 917461 gcgggatatc ggttttgcct tggcattttt gctgcaggtt ccaatcggtt tctccatgtc 917521 ttactaaaca aacggctgtc ataaaatccc cttcctgact ttattcatat cgctattata 917581 ctaaatcgaa agcgtgtgtc ctatgaaaaa gcctatgcaa gaacttcaaa taataaagcc 917641 agtccgattc cgccgccgct tccgatggct gcaacagcat attgacagtc tggccgtctt 917701 ttcgcttcat aaaacaatct ggttaccaga gctgcacctg atgcaccgta cggatggcca 917761 agagctaagg cgccgccgcg cacattgatt tttgaaaagg gaatgccgag ttcttgcgag 917821 cagacacaaa ttttgacggc aaaggcttca ttgatttcaa ataaatcgat atcatcaggt 917881 gttacatcgt gtgtatgtaa gagctgacga atcgcgacaa ccggtgccgc gggcggaaag 917941 ttggggtgaa tgccgctgac agcgctgccg ataaaccgaa gcacaggctt aagtcccagg 918001 gctgctgctt tttcttcttc cattaccaaa agagcggctg ctccgtctgc tatgccactg 918061 ctgttggctg ctgtgactgt tccggagctg gtgtcgaaaa ccggctttgc acggggaata 918121 atcgcttcta ttggccgcgt tttcaaaaat gcttcgtccg tctccaattc cccgagagca 918181 acaacttctt cacggtaaaa tccttcatca tgcgcgttcc tgctgcgttg atggctgaga 918241 agcgcgtact catcctgcat gcttctgctg atggaatagc gtgcagccgt atattctgcc 918301 gcaatgccca tgtctggatc gccgatcgca tctggagaaa agcgagcccg ttctgaaaaa 918361 ggggattggc tgctgctttc tgagccgccc gcgatataca tcgtgccggc tcccgcttga 918421 ataaggctgc aggcatagcg cacagcttca aggccggagc cgcactgtct gtcaattgtc 918481 attccgggaa ccgataaagg cagtccggct tgaagggctg acagtctggc caggttgccg 918541 cctctgccag tagcgtttcc gagaatgacc tcgtcaactt gatcctctag ctttcggctg 918601 agacagcgga tgatgggagc cgccaaatcc tccggcagga agggcttcag cagtccgttt 918661 tgatttccaa agatcgttcg ttttgcatca acaataaccg cattcattta tactgtacac 918721 tctcttccag ccattttttc actctggaac gggcaatttt tccgctgctc gtttccggca 918781 agctgtctgc aaacacccat tttttcggaa ttttatagga ggctaatttc tgtttacacc 918841 aggctttcag tgttctggca ttagcgtttc caagaatgac agctacagcg atttctcccc 918901 aatactcgtc gggaatgcca acgacagccg cgctttcaac ctctgggcag gcgagaagca 918961 cacgttcaat ttcttctggg aaaatattta atcctccgta cacgatcatc ccgttttctc 919021 ttcctgatat gtatagaaag ccctcttcat caacgtagcc catatcatct actgtcatcc 919081 attcatctgg tgtgctgccg ttcacatagc cggaaaacct catcgggctt ttgacaaata 919141 tttttccgat ttctcctggc tggcagcgtt ctcctccagc gttgcggatt tcgatccgga 919201 cattatgaaa agggcggccc gctgaatgcg gcttccgttt gctgtcttcc ggtgaagaaa 919261 acgtcacaaa actaagctct gatgtgccgt aaaaatcgta cagcttgaga tgaggccatg 919321 cagcggcaag cttcttcttg gattctgccg gccagtctgc gccggatgaa atgattttga 919381 cgggactgtc gggaaaaccc tcaatccttg cgagggcgtc tgtcatcgtc ggtacggtat 919441 agagaacact gatggattca cggcacagcc attccttcgc tttggcagga gaaaactttt 919501 tcagcaaaca aacggttcct ccgagaaaca aagtgctgac agccccatat aggaagtgag 919561 aggacattaa cgctccggga atcagaacct tatcatctga tgaaatcgaa aaatctgttt 919621 ctgtacaggt aaagctctcc atccatgagc ggtgagatcg cgtaaaggcc ttcggttttc 919681 ctgtcgagcc cgacgtaaat cccatataaa aagggtgctc cggatcaatg gtaggcaagg 919741 gatcagcggc tgcctcagaa atatctgcca tacagttatc cagcaataca acaggtgtct 919801 ggctatctgt cagtttgttt ttgaaaaagg ctaaagtaac cacaagatcc gcattgctta 919861 tggacagccg ctccttacat tcagccgggc tccagcgtgt gtcgatggga atggccgtac 919921 atccagccgc tgcggctccg gcaaacagct gtaaaaacgc gagactattt gggagcagga 919981 tcgccacacg attcggcatg ctcggctgtg accgcagcca atttgcggtt tgagagacaa 920041 gccgatccca atcatggtac gtgatttgct ccgattcagt ctggatcgct acacggccgg 920101 gcgatgtttc ggcagtagat gaataggtat gagtaattgt catgtattgt catcctcctt 920161 ttgtaaacat cgtatcagaa agagacaagg cttgagtgat ttttatcgcc agaaatgcag 920221 atacagccgc ttttatcaaa tcaccaggca catatgcaag gctcatgaag gcggcctgtg 920281 acaaatcaat atgcatgata aaagcttgta ccggtatacc aagcagataa ataaagatga 920341 tgccgaatac gatatgagtg aaaaagagac gcaatactgt caccttccgc agcctgttag 920401 cggctaaact gatcagccat gaagcgaggg gataagcaat caaaaagcct gcgctcggtc 920461 cgaaaaacac accaaaaccg cctcgtccgc cgggcaacag cggcgctccg aaggcgacga 920521 gcagcaaaaa gacaagctgg cttaagaaag cagactttgg cctgagaatg ctgcctgcca 920581 acatgacacc aagcgtttgc aatgtaatcg gaacgggtgt aaaggataag aagagagggg 920641 gcataaagcc gagcactgcc atcagcgcgg tgaaaatcgc aatatgcatc atgtcgatta 920701 atttcagcat gtgaaatcct ccaaaaagta atcaaatatg gttatacaat aaatgcaggt 920761 aattattatg tcaactgatt tttaatttaa gtttacataa tgaacgcaaa aaaaccggcc 920821 gtatggcaga ccggtttttg atggttattc ttctgtcagg atgacaagcg aatcaacgga 920881 agcggccaca tgggaaacgg cgcggctgac ttcctgaagc cctccaagaa aggcttgcag 920941 atcgacgtcg attttgcctg attgctcttt gctgattttc atgctgtgga cgatttcatc 921001 gaataagcgg ttaatttgcg tcattttttc tttactttcg ctgactagct cattcacgtc 921061 tttgatatgc ttggatacaa tgttgatttg tgtattcgta ttgttcacaa gctcagaaac 921121 agtagagacg gtttttttcg tatcctcaga aagcttccgc acttcatttg ccacgacagc 921181 aaagcctttg ccgtgttctc cggcgcgggc ggattcaata gatgcattga gcgagagaag 921241 gtttgtttgt tcagctatgc ctgtgacgat gccgaagatt ttttcaattt gctgcgcgat 921301 ttcatccagc ttgaccattt ctttttcgat ttggacaagg cttgtgtcaa ttttgttcat 921361 ctgtttttgc tggacttcta gctctttttt tccgccgatc gacttttctt caacagtgct 921421 ggatgttaca gtgccggctt tggatgcttg agaaatgcct tcagatttgt ccacaagctc 921481 ttgaactgat ctgcttgttt ctgaaaacag attggcaatc gatccagagg tttcttgaat 921541 tttctgatga agaaggtttt tcttttcttc ttgttcatca cgggtctggt tgtactcgct 921601 ttgaaacgct tcaaggacaa gctgctgttc taagttcaag atttttgttg ttgctttaat 921661 ggcttttagc agttcttgct gatttgtaat ggacgcttca taaatgtcaa tcattgacaa 921721 aaggagctct tgaaacgcac ccatatacca ttttggcaaa aggccgattc ttaaatggat 921781 ggaggcgatt cggttacgct tttcaataaa ttcatcatcg ataacgcctg caaacatttc 921841 ctgaatatgc cgttttaacg tttgttttaa gcggtcaact gagctgtgat cattaatgat 921901 atccatcaat gagctttcat ggtcaaggtt tttataaaac gcatcgacga tatttacgat 921961 attttcttga atgagtggct gaagctgctc taacacataa agctcagcat ctcccaacct 922021 gaccattttg agctgttttt tgacatctgc atgtttgttt gtgagctgaa tgcggttttt 922081 ttgttgtccg tttgaatctg aaaagtaagc tgtttcttgt tttctgtctt ttttaaataa 922141 caatacaatg atcccccttg ggaaaaatat aatttttact ttttggcttt ttaagccttt 922201 ttctttttta tcggccaagg gaaacatgaa tgaagctgca gatgaaaaat atttgaaaaa 922261 acgttcatta aaatgaacgg tttaatcgag atctatttgt tttaatggtt taatggccgg 922321 accctctaca acttcgccag atggcttaaa gcgtgatccg tggcacggac aatcccacgt 922381 atgctcactg tcgttccact cgacctcgca gcctaaatgg gtacaagtcg tatcaacgag 922441 atggaggcag cctgtctcat cacgaaatgc tcccgctcgc ctgccgttta tggtgacggc 922501 tttcccttct cctggcgaaa tgtcttcaaa ttggacatca ggcttttcaa gctttccttt 922561 tatcaaatgc ttggcgacat ctgcattgta ggaaatcact ttctgcaacc cgggattcag 922621 atggaaacgg gacggcgtga aaatgctttc gtatgggttt tcttttttct ccacaaggtc 922681 tgacaataaa gtggctgcga ctgctgagga cgtcatgccc cattttttga acccggtcgc 922741 tactagaata ttgtcctcat tttccgacat cggcccgata aacgggattt tgtcgatcgt 922801 cactagatct tgggtggacc aataatatgg aatgctttcg atgccgatgg tgctttcggc 922861 cagttgtctc agtgtttcat aatgtgtaga catggctttt ccctggcctg ttttatggct 922921 tactccgctg aagagaatca gcttttcacc gtttacaacc gtatagcgga gcgccactga 922981 cggctgatcg atactcaaat acatgccctc gggatactcg atcttcggct tgatggcaag 923041 gacataagat ctgtcggagt acattctcgc agcatataat ccgcctccgt cataaaaagg 923101 gaagtgggaa cagcatatga taaagcggct cttaatggcg tgccggcttt ttgttaccac 923161 ttcgggcctt tcgccttttt tgatatcaag cgcaacggtc tcttcataaa ttcggccgcc 923221 tttttgaaca atttgctcca gaagcgcttt taagtattga agcggatgaa attgagcttg 923281 attcttcatg acaagcgcca gcttagaacc taagggaatt ggaagatcct tgataaggtc 923341 tctttcaatt ccgagctttg tgtatgcctc atgctcggtg tggatttttt gaacagcgtt 923401 ttcatttgcc gtataaagat atgcgtcttg ctcgatccat tcacaatcaa tttgatgttc 923461 atccacaatg ccttttatgt aatcaattgc gttttggttt gcttcataat aaagcctcgc 923521 atggtttaat ccgaaatggc ggataaattc gtcgtatatc atgtcatgct gtgcggtaac 923581 tttagcagtt gtatgcgcag tggttccgtt aagaacctga tttgcttcaa tcaaaacgac 923641 acggaagcct ctcttcgtaa gttcatatgc cgttgtgatt cccgtaatcc cgcctccgat 923701 aatggtgacg tcacattcag tgtcctcttg aagcgcagga aaagaaggca ggtcagttga 923761 tgttttccag tatgtttcag gtgcttcctt tgcaaaatgt tgattagcca agccgttata 923821 cctccaatca gatttattct taatttttcc atattctatc ttttcataca taggaagcag 923881 gcattgttca taacataata aggttgaaaa ggagtgattt cattggcgaa tcaaaaaaag 923941 aaaacattac cgcctcagca ccagaaccag cagcctggtt ttgaatatct gatggacccg 924001 cgtccggttt ttgataagcc gaagaaagcg aaaaaattag agggcaaaac cgctattatt 924061 actggaggag acagcgggat tggacgcgct gtctcggtgt tattcgcaaa agaaggggct 924121 aatgtggtca ttgtgtattt gaatgaacat caggacgccg aggaaacaaa gcagtatgta 924181 gaaaaggaag gggtaaaatg cctgctgatt gcaggagatg tcggggatga agcgttttgc 924241 aatgatgtgg tcgggcaggc aagccaagtg tttccatcca ttgatatatt ggttaacaat 924301 gcagctgagc agcatgtcca gcccagcatt gaaaaaatca ccagccacca gctgatcaga 924361 accttccaaa caaacatttt ttccatgttt tacttaacaa aggcagtgct gcctcattta 924421 aaaaaaggga gctctattat taataccgct tcaattaccg cctataaagg caataaaacg 924481 ctgatcgatt attcagcgac aaaaggcgcg atcgttacgt ttacaaggtc cctttcccag 924541 tcgcttgttc agcagggcat acgggtcaat gcagtggcac cgggtcccat ttggacaccg 924601 cttatcccgg ccagctttgc cgcaaaagac gtggaagtgt ttggttcaga cgtgccgatg 924661 gaacgcccgg ggcagccggt cgaagtggcg ccaagctatc tataccttgc cagcgacgat 924721 tccacatacg tcacagggca gacgattcac gtcaatggcg gaacaattgt gaacggataa 924781 taaaaagcca atccttgaag gattggctta ttcgctctgc ttgagcgctg catattcttt 924841 agagagcgta agaaacgcat ctttatcttt ttcgtccaag gctttgttaa tttggtccgt 924901 cagcatggca agccgacggt tatacaagga ttcatcgagc accatttgaa tgtaaatatc 924961 cgtcattgtg acatcgaatt cttttgtttt ttgcgtgttg cgggacttca tgagctcagt 925021 gtacgatttt ttctctttca taaagaatcc ccccaatgcc ttttttatag tatatggata 925081 acggtcgaaa aaatcaataa atttttataa tttttagaca actaatactt ggcaatctat 925141 cgacatatcc tgcaaaatgc cgtaaaccgg caagtcttat gaaagtaaaa tcggtttatt 925201 actagtcatt tagtaccatt aaatatcatt aaaagatgat tttatcttaa atgttaaaaa 925261 aacctgtcgt tttacaaaaa cagatgatag attattagta taaattttgc agaaaaagga 925321 tggaggccat aatatgagtc agaaaacaga cgcaccttta gaatcgtatg aagtgaacgg 925381 cgcaacaatt gccgtgctgc cagaagaaat agacggcaaa atctgttcca aaattattga 925441 aaaagattgc gtgttttatg taaacatgaa gccgctgcaa attgtcgaca gaagctgccg 925501 attttttgga tcaagctatg cgggaagaaa agcaggaact tatgaagtga caaaaatttc 925561 acacaagccg ccgatcatgg tggacccttc gaaccaaatc tttttattcc ctacactttc 925621 ttcgacaaga ccccaatgcg gctggatttc ccatgtgcat gtaaaagaat tcaaagcgac 925681 tgaattcgac gatacggaag tgacgttttc caatgggaaa acgatggagc tgccgatctc 925741 ttataattcg ttcgagaacc aggtataccg aacagcgtgg ctcagaacca aattccaaga 925801 cagaatcgac caccgcgtgc cgaaaagaca ggaatttatg ctgtacccga aagaagagcg 925861 gacgaagatg atttatgatt ttattttgcg tgagctcggg gaacggtatt agaaaaatag 925921 gaaggagctg accgaacagg gcagctcctt tcataaagct atgccgtcgg aattcctccg 925981 gtgatgccat atacctgaga tgtcacatag cttgaattct ctgaagctag aaatacataa 926041 acatcggcca attccactgg ctgcccagcg cgatttaatg gagctggcgg cgtgccttgt 926101 ccgaatttcg ggatgttttc cgtcggctgt ccgccggaaa tttgcagcgg tgtccaaatt 926161 ggtccgggcg caactgaatt tactctgatg cctttggaag caagctgttt tcccagtccg 926221 acggtaaagc cgataatggc gtttttcgtt gctgcgtaat ctaacagcat cgggcttgga 926281 ttatagcctt caactgaggt agttgtgata attgaagctc cctccggcaa atacggaagc 926341 gccgctttta caacccagta aagggaaaag acgttcactt caaatgtttt atagatttgt 926401 tcagtaggca gatcttcgat gttttcgacc gcttgctgtt tgcctgcaac gagcgctagc 926461 acatcaagtc cgccgagttc gtgatgcgac tgtttgacta gatcttggca aaaggattcg 926521 tcgctcaagt ctccggggat cagcactgct tttcggcctt ctgcttcaat cagctctttt 926581 acctcttcag catctggctg ttcctcgggc aagtagttaa tagccacatc ggcaccttct 926641 ctggcgtaag caattgcggc agcgcggccg ataccggaat cgccgcccgt gacaagcgct 926701 tttcgacccg ttagtttacc tgatcctttg tagctttttt ctccgcaatc agggacaggc 926761 ttcatgttct tttgcaggcc tggcggttct tgatattgtt cgggaaattc atcatgaaaa 926821 aatgctttta taggattcgt aagatttgaa tcagacatca gcaacgctcc ttttctgttt 926881 ggtgtacatt cgtatgtgta cccctgagca taagcagaaa aacatgtttt ggcagtttga 926941 atagtgaagg aaaaagaaaa caagaaaaaa caaagccttc ttccatattt atcttgtcaa 927001 ataagactat atgaattatg ataaattcga gctataaatc aactaaatat tgggtgttgg 927061 gagagtgaat cgtcatgaaa aaagcggcgg cggttttgct gtcactcggt ctcgttttcg 927121 gtttttcata cggagctggc catgtggcgg aagccaaaac aaaggtgaag gtctataaga 927181 actgcaagga gctaaacaaa gtatacaaag gcggagtggc ccgcacatcg aaggtgaaaa 927241 acaaaggcgg aaaaacgaag tacaagcctt acgtttctaa ggcactttac gatgccaata 927301 aaaacaaaga ccgcgataaa gatcttatcg cctgtgaacg gtaaataaga aaaagcaatc 927361 tggtgtccag attgcttttt ttatgcttag gccgcctgat cggccgcagc gcttttcgcc 927421 ttccttgtca taaggctgac tgccatcatg accgtgatat tcaaaagcag ggcgacgatg 927481 ccgacattca agtcttttgc ggcttgcggc agagccggaa ataaagtgcc gatcgtcgtt 927541 tccgtcattg taatataagt aactgctccg acacctgcaa taatgccggc gaaagctcct 927601 tgctttgtca ccatattatg cttgagcagg ctgaacaaaa gggcggggaa tagctgtgtg 927661 acaaggctgt agcccatcaa aagcagcgta acgatggtat tcccgccttt gaaggtaaaa 927721 tacaccgaaa tcagcgcaat caccggcact aaaaacttag caagcgccga tacttgctgt 927781 tctgtcgtgc ggggcgcgat taccttgtac acattttttg caaacagtgt ggaggcggac 927841 attaagatca tagaccctgg cacaagtgct gtcagcagtc cggcagcacc gataattccg 927901 acaaaccaag ggtcaaatgc ttgcagagac agtctcaaaa gcgacaaatc cccgtctgcg 927961 ccattcagat ctggaacttg caggatagcc gcaaagccga cgaaaaggac gaagagcagg 928021 accagctggt acaaaggcat gatgatggcg tttttacgaa acacttttgg gttttcggct 928081 gaatacgaag cggaaaacgt gtgaggccac atgtaaaaac caagcgctgt caagagtacg 928141 gttgaactga accaggccac actttgtccc gattcgggga gcgtaagaaa gccaggcttt 928201 gccgtttcaa tctgctgaaa catgtcttga aatccgccgt agtaatgaat tggcaaatac 928261 acacctaaaa acagaacgac aaccagaatc atgatgtcct tcacaaccga tatccaggca 928321 gacccgtgaa tgcctgaaac cataacataa accgtgatgg aaacagcgcc gatccagatg 928381 gcagcggtcg gggtgatttt gccgtacgag gtttccgata caatcagccc gaggcctttc 928441 agctgcagta caagataggg aatgagtgcg gcgatgccga ccagtgaaac gagaatgcca 928501 agcagcggac tgttgtattt ttttgtgaaa aaatcagact gcgacatcag tttatgctgt 928561 ttcgcgtacg tccaaactgc tggaagaagc cagtaagaaa ggatgtaggc cagacatccg 928621 taggcgatga tataaaaggc tggaccgcct tttccgtagg cccagccgct gccgccgaga 928681 aacgtaaaag tagtataaat ttcgcctgcc atcaaaagga agacgaaaac agttccgaag 928741 ccgcgccctc cgaccgtcca ctgctccagg ttcatgtctt ttcctttttg ggcgcgtata 928801 ccgagaaaaa tactcaagag caggacaccg aagatgatga tgagagctgc attcattctg 928861 cttcctcctt tttattttcc ttgtcgagga catacacaat cgccatcagc gcagaggtca 928921 aaagagccca catcacaata taggcaagaa taaacggcat gccgaacaca tagggggtca 928981 ccttatttgc aaaagggatg ccgagtaaga ttccgataaa gggtaaagcg gcaagaacgt 929041 gaatcagttt catagaatcc tccttctatt taggattgag gtgtacaagc ctaagcgtac 929101 tgaaaatgat gtcgcagata tcgcagcaca tgtcattttt tggagtgaaa ggctgtggtt 929161 cgaattataa ataaatttat tttgtttgta tagtgtgaat tgtctgaaat taatgctctg 929221 aatcgcccga agagggaacg ggcagtatga ttcaaaaggc tcagagtctg tctggggcaa 929281 atagatagta tgttaataat tcgctgacct gctcacggat tcgcggatta aaatagcgat 929341 ggttttcttc ataaccgtcg atgacaaatg tatagagtgt aaaggcctca tcgcgttccg 929401 tctcgcggat tgcaattttt cttttcctca gttcttttct gacctccatc aaatcctttt 929461 gtgctatttt taatgattcg ctgataagct gtttataagg atgcttcaat tttaatgtgc 929521 tttcttcaat tccggcgaga tcacggttaa aaatcgtaat ggccatgggc aaaaagagag 929581 cccgttcaat taaatcgtat atttcctcct gcagatttgg catattgact ccttctttct 929641 aagggaacgt ttgttctatt tgtattctat atcggctggt gaaatgtttc aagacagaaa 929701 aaatcaccaa aactttttag ttttctgctg ataatgtgta gaataaggat agacaaaccc 929761 ggtaaggagt ataaatgttg gagcattttt tatcctattt gacacaagaa catttaactg 929821 aattatttca aagctatagg gctttcggtc cgctcattgc tgtgctgctg cctttaattg 929881 aagcatttct cccgtttttg ccgctgatcg tgtttgtggt ggcgaatacg aactcgtttg 929941 gcttgtggga aggattcatc ctatcctggg cgggatcaac tgctggttcc attctcgtct 930001 ttttgattgt ccgtcaatac ggacagagaa aattgcttgg atttatccgc agtcatccgt 930061 ctgtcagaaa gctgatgtta tgggtggaaa gacacggctt cggtcccatg tttcttctgc 930121 tttgttttcc atttacaccg tcagccgcgg tgaatgttgt tgccggtttg tcaaggatcg 930181 gaacgcggcc gtttattttg gcggcagcct cggggaagct tgtcatgatt tttatgatca 930241 gcttcatcgg atatgatctg cacgcgctga ttacacagcc gattcgaacg gtcatcgccg 930301 tattggtgat cactgtctta tggtatgtcg gcaaaaaggt ggagcggtat ctgcatgtaa 930361 gagccagtca gcgtgagcat gatggaggga gacagtaaca tgaaaaaacg gttttggttt 930421 cttgccggtg tagtgtccgt tgttctcgcc attcaggtta aaaatgctgt ctttattgat 930481 tacaaggtag aaggcgtcag tatgaacccg accttccagg aaggaaacga attgttggtc 930541 aataaatttt cgcatcgatt taaaaccatc catcgttttg acatcgtcct ttttaaaggc 930601 cctgatcata aagtgctgat taaacgggta atcggcttgc ccggtgaaac gatcaaatat 930661 aaagatgatc agctgtatgt gaacggaaag caggttgctg agccattttt gaagcatttg 930721 aaatctgttt ctgccggcag ccatgtaacg ggtgattttt ctttgaaaga tgtgacggga 930781 acaagcaagg tgccgaaagg aaaatatttt gtcgttggag ataatcgcat atacagcttc 930841 gacagccggc attttggtcc gataagagaa aaaaatattg tcggtgtgat ttctgatgcc 930901 gaataaaaag acgctaattg aagaggcgtc tttttgtatg ccgtttggaa aaatgtgttg 930961 aagaaaaatt tgtaaggagc tataatcaaa attgttacct gtgtaacaaa atttatatat 931021 ttttttgact ggagggccgt ttttattggt ttttgttcgt ttttcatgaa acaaaaggag 931081 tggtgaatga tgatgaaata tgaagcagtg attataggag gagggccggt tggatttatg 931141 ctggcttctg agcttgcaat agccggagtg ggaacatgtg tgattgaacg gcttgaaaaa 931201 cctgttccgc attccaaggc gttgacgctg cacccccgaa cgctggagct tcttgagatg 931261 agagggattt tagagcggtt cgtatccaag ggaagcaaga tacctaccgg acatttttca 931321 atgctggata cccgtctgga tttttcaggc ttggatacga gctgtcctta cacgcttttg 931381 ctcccgcagt ccaaaacaga aaagcttctt gaagatcatg cacgaagcct gggaacagag 931441 gtgtttcggg gtgccgaggc gctggcggtt acgcaaaacg gggaagcggt ccaaacaatt 931501 tttaaggatc gggacggcag tgtacggacg atcacaagca agtttgccgt tggggcagat 931561 ggcgccggga gtaccgtccg gaaacaggcg aaaattgagt ttccgggaac agacagcact 931621 gtcaccgctg cgcttgggga tgtggtgctc ctttctccgc cgccgtcagg tgtgctgtcc 931681 ctttgcacaa aagagggcgg tgttatgatt gttccgttat ctccagaccg ataccgtgtc 931741 gttgtgatca gcccttatcg cacacaaacg ccgaaagatg tgcctgtgac tgaggaagag 931801 ctgaaagctg acctcctgcg aatttgcgga actgacttcg gtttaaccga cccttcgtgg 931861 atgtcgcggt ttgggaacgc cgcgcgccaa gcgaaacggt atcgggacgg cagaatcttt 931921 cttgcgggtg atgccgcgca tattcatttt ccggcgggcg ggcaaggact gaatgtcggc 931981 cttcaggatg caatgaacct cgggtggaaa ctggcggcgg ccatcaaagg ctctgcgcct 932041 tcttggcttt tggacagcta ccatgatgag cggcatccgg cagcggaagg gctcctcaga 932101 aacacggagg cacagacaaa gctgatcgat ttcactcaag caggcctcca tttgcgaagc 932161 atgatgtcgg agctgctggc cttccctgat gtgaatcgat atgtagcggg gcaaatttct 932221 gcgctcgatg tcagatatga agctgatcgt accatgccgc cgaatcgttt gaacggggca 932281 aggctccctg acatgaagct gattctttcc gacggcaatt cggaacggct gtacagcttt 932341 ctccaaaacg ggacattcgt tttgctgtca ttgaggcagg aagctgatga tcatatcgaa 932401 gtaaaaggct tacgtacggt aaccgcctcg cttgcagaac cgaatgaaaa gttgcggaat 932461 gtgcatacca tattgattcg tcccgatgga catgtagcct gggcggtgga tgcatcagcg 932521 cccgattgtt ccgaggtgat tcaaaaaggg atcagccgct ggttttccgt caccagccga 932581 gtataattca attcgattgt ttcatctgta acaaaacggt atgatagaag aaacaatcga 932641 atgaaaaagg atggaaaacc cgatgaacac agatcatacg aaacgcaatc tttttgaatt 932701 gtatgcggag ctcattcatc agcaggagaa atgggagggg cttattaaag cctttttatc 932761 tgacgaattg aggaagctgg atgtagagca cgggagtaaa tctcaattga cgatgacaga 932821 aattcatgtt ctatcctgtg tcggggacaa tgaaccaatt aatgtcacgt cgatagcaga 932881 aaaaatgaat acgacaaaag cgactgtatc acgcatcagc acaaaattgc tcggcgcagg 932941 cttccttcac agaacacagc tcagcgataa taaaaaggag gtctacttcc gattgacgcc 933001 tgctggaaaa aagctgcaca gtttgcacaa atattatcat cagaaggctg aacagcgttt 933061 tctgtcattt tttgaccgct ataccgagga agagattctt tttgcggaac ggctgtttcg 933121 ggatctggtg acaaaatggt atccgtcgtc agaagaaatt gaaggggggc ttcctagcat 933181 ttttaaataa aaaacacgca ctgcggtgcg tgtttttcgc tttgcggccg cctcgagaat 933241 tctttcattt caccctctgg cagcactcac ttcaaatctg atccattaac aacgaaatat 933301 ccgcttatat ttcctcatct cgatggtttg cgaattaaaa gttcttgaac ccttttttca 933361 actaggcact actgccgctg attgagctct ttttgtcttt tttttcacca tgaagatggt 933421 gaagcaggcg ataaaacggc ggcagcaggg caataaccag aatgacgcga atgacctgaa 933481 ccgcaacgac aaaggtggaa tcagcatgta aggtaactga cgtcgtcgcc atctctgcaa 933541 tcccgccggg cgcaaatgcc agaacagaag tgatgagcga aattcctgtc agctcggaaa 933601 cgatcacggc gctcaaaaac attgctgcga ttaaaccgac ggacgagaca aacccgacga 933661 tgataatacg ggtgacgccg gcaaacatgc ttttgtacat cttagagccg atcgttgccc 933721 cgagaaatac ttgtgataca tggttagctt gtgacaacca ccatgccgtc atgtcgtgcc 933781 ctgtcaccgc agctccgcca acatgtacaa ttgctacacc gagcatgctg ccgagcagcc 933841 atggagctgg aaattttaaa aatttcgcag ctttgcaagc tccccaggca gcgagaataa 933901 gaatgacggt ccacaaaacg ggagcgagcc taaaatctgt cgttgcagaa gaaatcgtct 933961 ctgctgcggc acttgcggta cgatcttgtt ttgtatagat cagaatgact aaaaacggaa 934021 tggaaagcac cacgagcagc acacgcatca tttgaacgag gctgactata gcggtattgg 934081 cgcctacttc ctgtgcgatg ctcggcatgg cggaaagtcc gccgggagcg gtgccgacaa 934141 agctagtcat catatccgtt ttgctgaaac gccaaagcac atatcctgac agcatggcca 934201 gcaggataga caatatcagc ataacgccga ctgaaaacca atggtctttg agaacagaga 934261 gaacggataa attcagcttt tggcccaatt cgatgccgag gatcatctgc ccgagggcga 934321 gccatcgtcg gttaattcct ttttggtctg gtgccatcat cagccatgcc ggccgtatca 934381 tggcgaggca gcaggcgaca atcagtgttc cgatcatcca tccaattgat attccggtta 934441 atgaaagaat aaaccccccg gctgcactga ttgcgataaa ccatagatct ttgaggagat 934501 tttcgtcttt cttcaatgta aaacccttct tcctttttca cgtaacactc caattgttca 934561 cgtagtgaat gtatttatta ctatagtata tttttgttga taaagaaatt atgaattatt 934621 ttctataagc gattcacttt tcttatgacc ttgtgttcga gcttttctat tgtgtaagtc 934681 agagataaac ccgctgtcag cagacacacg gcaagagcgt aaaaaatcac ttctccgcca 934741 aatgatgtca ggatcagccc gcctgccagc ggtccgattg agcgggatat atcccaatgc 934801 agaccataga cagcataaaa ccggcccagc aaatgaggcg gcgccaattt cgatatgaag 934861 gtctggatgt gggttagccc gatgctttca ccaaccgtca tcaccgctgc cgtcactaaa 934921 agcattgtca gagaggttga gcatgcaaag ccggctgccg caagggagta gcaaatataa 934981 gtaatgaaga ggatcgtttt cattgaaagc ttttcggtcc ctttgacaag aggtacttgg 935041 agaacacagc tgaataaagc ttttgctgct gaatagatgg tcagcatgga cagataatca 935101 gaaaacatgt ttttgctgaa cagcctgtat gttgtttctg tttgtgcata taacatgctg 935161 atggggagag aaagcagcaa aagaagcagg acaggcctgt atattgtaaa gctcgcggac 935221 attttcgggg taacagctgg gtgtagcggc tttgtctcag gcagtttcag tgcagcgatc 935281 agaaagtaga taaacaatgc tgcagcatct aatgcgaata tccacacggg gttatgattg 935341 tacagcagca tccccactag cggtcctgcc gtcagacccg tcgaatagat cgcattgatg 935401 accgcaaaca cttccgaacg tctgctttcc ggcgtgcttt cagcgatttg ggcgcgggaa 935461 gcgggaatgt acaacgatct tccgatgcca ttcatgacat agagaatagc gaaaacatac 935521 gcatgctcag caaatacaaa ccctgtcatt gccgctgatt gaagaagcaa tgcggtcaaa 935581 atcgctgtgc gccgcccaag ccgatccgtc acccgtcctg cagcgagcgt caggaaaata 935641 tcagcaaatg gctgaaggct gatgatcagc attggcatca tgatactgcc gtttaattgt 935701 tcatgcagat acagcaccat aaaaggtccc atcattgcac ctgtcaggct tgtcagcaat 935761 tcgccgaaaa agcggagccg aacgggagcg gtatatctcg attttataga gtgaaaactg 935821 gtcaacatgt gatcgccgcc tttcgctgtt tgatatagta gtagtgtata gaaggggcgg 935881 cggcccaaaa agtgaagaaa agaagagata aaagttcccc ttttgtcggg aggtgcgggg 935941 attgaagctg atagagcact acgtggcgct tgtaaaaaca ggctgcgccg agtatgggca 936001 aatgaacgaa atgacgctca ctgagattgc cgactgttta ttttgtacag aaagaaatgc 936061 aaagctcatt ttacataagc tggagaacag caattggatt atccgggaaa gcggggcggg 936121 gcgcggccgc aaatctaaaa tcgcgtttct tcggaggcct gaggaactgc ttcttcaaac 936181 tgcaaaggaa tataccatgt caggaaagct taaaaaggca aaggagctgc ttcagcagta 936241 tcagtccgcg tttccagggc ttcaaaacga atataacatg tggctatcag aggtattcgg 936301 atttgtgacg gagacaggcg agaatggggc gaaggatgtc ctgcggctgt tcatcacgcc 936361 tgaatctgtc agcagtttgg atccatgcca aatatttttg cggtctgagg gccatttcgt 936421 caaacagata tttgatacac tcttcacgtt tgattcggat atgcaggagc cgaagcctca 936481 tttggttcat ggatgggaag aggtcggaaa aaaacaatgg agattttttc ttcgaaaagg 936541 tgtgttattt cataatggac agccgctgac atcgcgggac gttgcgttta catttcagcg 936601 ctttttggaa ctggctgaca acccgtataa atggcttctg cacggagtga aacaagtctt 936661 agaaaagggc ccttattgtg tggagctcat actcgataag ccgaatgcgc ttttgccgta 936721 tgctctttgt gatgaacggc tgtccatact gccggcagaa cagggcggcg ggaaaaatgg 936781 aacagggcct tttcagatga atcagcaaca tagcgggatg cttgtgcttg aagccaatga 936841 gcgctacttc aagggacgcc cctatttgga tcgcgttgag tttgtgtttt ctgagcaagc 936901 cggagagatg aacggtttta ccattcaaga aaaacaaaca tgtcctgagc agcaaactgt 936961 ctttgatgag cggcatgttc agtatttgtc gcttaatctg aaaaagaagg ggcctcttca 937021 gcaccgaagc tttagaaaag cgctccggct gctgatttcc tctgaacggc tcgttcgtga 937081 agcgggaggg caccgaagaa ttccggttac gtcctttttg catccgagtc cttttgagtg 937141 ggagggcgtt tcgccatctg aattgttgaa aaaaagcgga tacgagggcg aaacaatcgt 937201 gctttatacc ttttcggaaa cggatcatcg tgaggacgcc gaatggattc aaaatatttg 937261 cgcccagcac ggtatcaggc ttacacttca attctgtgat gctgctgatc tgcgacggcc 937321 ggaaatcgtg cagatggcgg atatcattca tgacagtgcg acgttttatc aagacagcga 937381 gtttggtttt ctgcatttgc tgctgtcgga gaacagtttc ttgtatcagc atctatctga 937441 aaagctgaca cagatttgct caggaatgac agagcggatg ttttccatgc ctgaccgctg 937501 ttcgagaatc aacatcctgc gtgacattga ccggcagatg atacaggagc tgaacgcgat 937561 cccgctgtat caaaatgtgc tccaggtgac atcaagtaaa aatgtaaaag gcctggtgct 937621 tgatgaagag ggatggattg atttgtactc cgtatggctg tccaaataaa aagagggttc 937681 ttttttgaac cctctttttt acgctgccat gctgcggcat tgttcagcac aggtgaagca 937741 ggctttcgca catgcttggc aatgatcatg atcgtgcttt ccgcattcag tgccgcatgc 937801 ttcacaaata tcggcgcaaa gtgcacaaat ttctttcata aacgggctgt ccgtttgcat 937861 ggctttgacc gccagcgcgc aaatatccgc gcattccctg tcaagccgga tgcatccgct 937921 gagatgatgc tgcacgcttt cttccaagca tttagtgaaa caatgattgc aagccttcat 937981 gcaatcgatg caagcctcaa tacaagcctc agaatattgc tccatggttg attccccctg 938041 tatgacagta tatggtttta tgtttcacgg ctgcatttga aaaaaacagg ggagtgtgtt 938101 tttagctaag gggatatgta catataccct gaatgggtat atctaacgtt ccatcagata 938161 gtataggaac cagacagcgt gattttgttc atcacgtgct gcgcgcgtaa agacgccttt 938221 cgcttttaag tttgacgttt cctcggccgc acgcaagtaa aagtcgacgg tttcttgttc 938281 atctttaaaa gcggcgtcca gtcctcttgt gaaattgtcc gggcattctt ccgtttgttt 938341 cggcatgatg tgtttgccgg taattgaacc atacagtgtg gaaaattcac ggaggtggcg 938401 aatctcgtca cgcctgattt cttcaatctg ttttctgacc tcatcgctgt gggcgagttc 938461 ggcaagcttg cggtagcatt gaatagcact gaattctccg ttgatggcct tctgcaaatt 938521 ccgaatcaaa acaggatctt cccggtatgg caccggatag ggatagtagc tgtaatgcaa 938581 ggggattcaa ctccattctt aggaattggg cttctgtaaa agtatatgtt gggcagggag 938641 agatgtgcgg agataatcag ctttttatat gtgaaaaggc cgtttttacc aatagatcag 938701 attggtcatt ttcgtcaaca ttcgataaaa tatagagaga taaaaagaga ggggtcttct 938761 aatttgggag cagagttttt agtaggcagg tccgggagtg gaaaaacgaa gctgatcatc 938821 aacagcattc aggatgaatt gcgccgggct ccattcggga agccgatcat ttttctagtc 938881 ccggatcaaa tgacgttttt aatggaatac gagcttgcta aaacgccaga tatgggcggg 938941 atgatacgcg ctcaagtgtt cagtttttca cgattggcct ggcgcgtcct ccagcatacg 939001 ggaggaatga gcaggccgtt tctgacgagc accggcgtac aaatgctcct gcggaagctc 939061 attgaggagc ataaacagga gttcaaagtc tatcaaaaag cgagtgacaa aagcgggttt 939121 accgcacagg ttgagcggat gctgacagag tttaagcgct attgtctgga accggaggat 939181 atccgccgga tggcggaaag cggaacggct tccgagtatc gcggagaacg tgttttatct 939241 gaaaagctcc atgacttatc aattctgtat cagcaaatgg aaaaaagcct cgcagatcaa 939301 tatcttcact ctgaggatta tttgacattg ctggcagagc atatcccgct tgcggaagat 939361 ataaaaggcg cccatatcta tgtggatggc ttttatcagt ttaccccgca ggaattcagg 939421 gtgttggagc agcttatggt tcatgcggag catatcacgt tttcgctcac agcggacaag 939481 ccgtcatatg agcgggagcc gcatgaactg gaattgttca gaatgacggg gaaaacctat 939541 taccgcctgc atcagaaggc gaaggaactg aatttggaca ttacgtataa agagctgagc 939601 gggactgagc ggcatacaaa gacgccggaa ttggcgcatc tagaggcaca gtatgaagcg 939661 cgtccggcca ttccatacgc agaaaaacaa gaagccctta ctgtgatgca ggccgcaaac 939721 agacgagctg agctggaagg cattgctcgg gaaattcacg ccctagtcag agagaaggga 939781 tatcgctata aggatgtagc aattcttgcg cgccagccgg aagactacaa ggatatggtg 939841 aaggaagttt tcgcagatta cgagattcct tatttcattg acggaaaagc atctatgctg 939901 aaccatccgt taattgaatt tatccggtcg agccttgatg ttctgaaagg gaattggcgt 939961 tatgaagcgg tgtttcgctg cgtgaaaacc gaactgctat tcccgctcaa tgaaccgaag 940021 gccaaagtga gagaacaggt cgatcagctc gaaaattact gtatcgccta tggtattaaa 940081 ggcgaccgct ggacaaaggg cgatcggttc caatacaggc gttttgtgtc attggatgat 940141 gattttgcgc agactgatca ggaaatcgaa atggaaaaca tgttgaatga cacccgcgat 940201 tggattgttc cgccgctttt tcagcttcaa aaacgcatga aaaaagcgaa gacggttcaa 940261 gagaaggcgg aggcgctcta tcgttattta gaagagacgg atgtgccgct gaagctggat 940321 caggaaaggc agcgtgctga ggatgacggc agaatcattg aagcgcagca gcatcagcag 940381 gcgtgggacg cagtcattca gctgcttgag gagtttgttg aaatgatggg agatgatgag 940441 atttctcttg atttgtttca gcaaatgata gaagccggcg cggagtcgct tacattttct 940501 ctaattccgc ctgcgcttga ccaggtgttt gtcggcaata tggatttgtc cagaatgtat 940561 ggcacctcct gcacctttgt gctcggggca aacgacggcg ttctgccggc acgccctgat 940621 gaaaacgggg tcctgtcgga tgatgaccgg gaatggctga aaacgattgg ggttgagcta 940681 tcctcaggcg gacgagagcg tttgcttgat gagcacttcc tcatctacat ggcgttttca 940741 agtccgtctg accggcttta cgtatcgtat ccgattgctg atgcggaagg aaaaacgctt 940801 ttgccgtcga tgatcgttaa gcggctggaa gaactgtttc cgcatcataa ggagcgcctg 940861 ttaacaaatg aacctgaaca ggtcagcgat gaggaacagc tgatgtatgt tgtgaataaa 940921 agcgtggcac agtcctttac cgcgagccag ctcaggttat ggactcggga atacgacatc 940981 agcgacgtct ggtggagcac gtacaatgtg ctgatgagtg agcaggacag gctgcaatcg 941041 aaaaagctgt tctcaagcct gtttttccgg aatgaagtga agcagcttga acgcagcgtg 941101 tcgagacagc tctatggtga acgtattcag ggcagtgtat cgagaatgga aacctttaac 941161 gcatgcccgt tttcccattt tgcgtcacac gggctgcatt tgaaggaacg gcaattcttc 941221 aagcttgaag caccggatat cggccagctg tttcattcca gcttaaagct gatttcggac 941281 aggctgcgtg agcaaaagct ggattggcgc gatttaacga aggagcagtg cgagctgttt 941341 tcctatgatg cggtagagcg gctggcaccg aaactgcaaa aggaaattct gctcagctca 941401 aaccggcatt attatgtgaa ggaaaaactg caaaaaattg tgacacgtgt gtccggcatt 941461 ttaagcgagc atgcgaaagc gagcggattc gtaccgatcg ggcttgaact gggctttgga 941521 ggaaaagggc cgcttccgcc gctgaccttt caactgaaaa acggctgtac gatggaactc 941581 gtcgggcgaa ttgaccgtgt tgataaggct gaaagctcaa aaggcctgct cctcaggatt 941641 gtcgattata aatcaagcga caaaggcctt gacttagcgg aagtatatta cggattggca 941701 ctgcaaatgc tgacgtacct tgatttatcg attacacatt cagctgactg gctcgggatg 941761 agggcgacgc ctgccggagt gctgtatttc catattcatg acccgatgat tcaatctaat 941821 ctcccgcttg ggcttgacga gattgaacag gagatcttta agaaatttaa aatgaagggc 941881 ttgctcctcg gtgatcagga agtggttcgc ctcatggata caacccttca agagggacgt 941941 tcaaatatca taaacgccgg cttgaaaaaa gacggctctc tcagatcaga ctcagcagca 942001 gtcggtgaaa aggaatttga tcttttgaca aagcatgtgc gccgcacctt ccaagaagcg 942061 ggcgaacaaa tcaccgacgg gcgcgtatcc attgagccgt acaaaatgaa gaacaagacg 942121 ccgtgcacat actgtgcgtt caaatcagta tgccaatttg atgaatcact ggaagaaaac 942181 gagtatcgcc cattaaaggc tgaaaaggac aagacaatac ttgagtggat aaaaaaggag 942241 gcggatggca atgaacattc ctaaaccggc agacagcaca tggacagatg accaatggaa 942301 tgccattgtt tcaaccggcc aggatattct tgtggcagcg gctgcgggct ctggtaaaac 942361 cgctgtgctc gttgaacgaa tgattcggaa aatcaccgcg gaggaaaacc caatagatgt 942421 agaccgtctt ctcgttgtga catttacaaa cgcctcagcg gcagagatga agcaccgaat 942481 cgcagaagcc ttggaaaaag agcttgtaca gcgccccggc tcgctgcata ttagacgcca 942541 gctgtctctt ttaaaccggg ccagcatttc gacgctccat tccttttgcc tgcaagtgct 942601 gaagaaatat tactacttga tcgatcttga tccgggcttt cggatagctg atcagacgga 942661 aggcgagctg atcggggatg aagtgcttga cgagctgttt gaagacgaat acgcaaaggg 942721 cgaaaaggcg ttttttgagc ttgttgaccg ctatacgaca gaccggcatg atctggatct 942781 gcaatttctc gttaaacagg tgtacgagta ttcccgatcc catcccaacc cggaggcgtg 942841 gctggaaagc tttgttcatt tgtatgatgt atcagaaaag agcgccatcg aggagctgcc 942901 gttttatcaa tatgtcaaag aagatattgc aatggtgctt aacggggcga aggaaaagct 942961 cttgcgcgcg cttgagctga cgaaagcgcc gggcggcccg gcgccgcgtg ctgacaattt 943021 tcttgatgat cttgctcaga ttgatgaact gattcagcat caggacgatt tcagtgaact 943081 atataagcgg gtgcccgccg tctcttttaa gcgtgccaaa gcagtaaaag gggatgagtt 943141 cgatccagcg ctccttgatg aggcgacaga tttgaggaac ggcgcaaaaa aactgcttga 943201 aaagctcaaa accgactact tcacgcgaag tcctgaacag cacttgaaaa gcctagccga 943261 gatgaagcct gtcattgaaa cgctcgtaca gcttgtcatc agctatggaa aacgattcga 943321 agctgcgaaa caggaaaaat caatcatcga tttttcggat ttggagcatt actgtttagc 943381 gattttgaca gctgagaatg acaaaggtga acgtgagccg agcgaggctg caaggtttta 943441 tcaggaacag tttcatgagg tgctcgttga cgaatatcag gataccaacc tcgtgcagga 943501 atcgattctg cagctcgtca caagcggtcc ggaggagact ggtaacctgt ttatggtagg 943561 agatgtcaaa cagtcgattt atcgattcag gcttgcggag ccgcttcttt tcctctctaa 943621 atacaaacgg tttacagaga gcggagaagg cacggggcgg aaaatcgatt taaataaaaa 943681 tttccgaagc cgggctgata ttttagacag cacaaacttt ttatttaaac agctgatggg 943741 cggcaaaatc ggtgaggtcg attatgacga gcaggctgag ctgaagcttg gtgcagcgta 943801 tccggacaat gacgagacgg aaacagagct gctgctgatc gacaacgcag aagatacgga 943861 tgcaagcgag gaagcagaag agcttgaaac ggtgcagttt gaggcaaaag ccatcgctaa 943921 ggaaattcgt aagctgattt catcgccgtt taaggtgtat gacggaaaaa agaaaacaca 943981 tcgcaatatt caataccgag atatcgtgat tttgctccgt tcgatgccgt gggctccgca 944041 aatcatggag gagctgagag cacagggcat accggtttac gccaatttaa cgtcaggcta 944101 ttttgaagcg gtcgaagtcg ccgtcgcgct ttctgtgctg aaggtgattg ataatccgta 944161 tcaggatata ccgcttgcct ctgtgctgcg ctcaccgatt gtcggagcag atgaaaacga 944221 gctgtctttg atccggcttg aaaataaaaa agcgccgtac tatgaggcga tgaaagacta 944281 cctggctgct ggtgaccgga gcgatgagct ttatcaaaag ttaaatacgt tttacggaca 944341 tctgcaaaaa tggcgcgcgt tttcgaaaaa ccactcagta tctgagctga tttgggaagt 944401 gtaccgcgac accaaatata tggattatgt cggcggcatg ccgggcggaa aacagcgcca 944461 ggccaatttg cgtgttcttt atgacagggc gcgtcaatat gaatcaacgg catttcgcgg 944521 cttgttccgt ttcctgcggt ttatcgaacg catgcaggag cggggcgatg atcttggtac 944581 ggcgagagcg ctcagcgagc aggaggatgt tgtccgctta atgacgatcc acagcagcaa 944641 agggctcgaa tttccagtcg tgtttgtagc aggtctcggc cggaatttca acatgatgga 944701 tttgaacaaa tcgtacctgc tggataagga gctcggattt ggcacgaagt atattcatcc 944761 gcaattacgc atcagctatc cgacacttcc gctcattgcg atgaagaaaa aaatgcgcag 944821 ggagctgctg tcagaggaat tgcgtgtgct ctatgttgca ttaacgagag cgaaggaaaa 944881 gctgtttctg attggctcat gtaaggatca tcagaaacag cttgcaaaat ggcaggcatc 944941 cgcgtcccaa actgattggc ttctgccgga atttgaccgc tatcaggcga gaacgtatct 945001 agatttcatt gggccggctc ttgccaggca cagagacttg ggggatttgg ctggtgtgcc 945061 agcacacgct gacatctcag gtcacccggc tcgttttgcc gttcaaatga tccattccta 945121 tgatttgctt gatgatgatc tggaagaaag aatggaagaa aaaagcgagc gcctagaagc 945181 gatccgccga ggtgaaccag ttcccggctc gtttgcgttt gatgaaaaag cccgcgagca 945241 gctgagctgg acctacccgc atcaagaagt gacgcaaatt cggacaaagc aatcagtttc 945301 tgagatcaag agaaaaagag agtacgagga tgaatacagc ggcagggccc ctgtaaaacc 945361 ggctgatgga agcattctgt acagacgtcc cgcttttatg atgaaaaaag gcctgacagc 945421 ggcagagaaa gggactgcca tgcatacggt tatgcagcat atcccgctgt cacatgtgcc 945481 gtcgatagaa gaagctgagc agacggttca caggctttat gaaaaagagc ttctcactga 945541 agaacaaaaa gacgctattg atatagaaga aatcgtgcaa tttttccata cagaaatcgg 945601 cggacagctg atcggtgcta agtggaagga ccgggaaata ccattcagct tagcgcttcc 945661 ggccaaggag atctatcctg atgcacacga ggcagatgag ccgcttttag tgcagggtat 945721 tattgactgt ctctatgaaa ctgaggacgg attatatcta ttggattata agtcggaccg 945781 gattgagggc aaattccagc atggatttga aggagcggcc ccgatcttga agaaacgata 945841 tgaaacgcaa attcagctgt acacgaaggc agtggagcaa attgcaaaaa caaaggtaaa 945901 gggatgtgcg ctttatttct ttgacggagg gcacattctg acattatagc gagatccata 945961 agctccggaa tttcaggcgg agcgggtctc gttttctata taaaagagag gtgaaagcat 946021 ttgcggattt tacatacggc tgactggcat cttggaaaaa cgcttgaagg aagaagcagg 946081 ctgagtgaac aggccgatgt gctggatgaa ctgaatacga ttgtaaagga tgagcagatc 946141 gatgccattg taatggcggg ggatgcattt gacaccgtaa acccgccagc tttagccgag 946201 cagctgtttt atgaaagcct gtctgcgctt agcgacagag gaaagcgccc gatcgtcgtc 946261 attgccggaa atcacgataa tcctgaccgt ttgtccgccg cttcaccgct gacacatgaa 946321 aacggcattc atttaatcgg ttatccgaca acagagccga ttcatattga agtgccttca 946381 gcaggagagc ttttggcggt tggagcgctg gcgtacccat ctgaagcgcg gttaaatgaa 946441 gtgctatccg atacgtttga tgaaaagctg ctccgtgatc actatgatgt gaaaatcagg 946501 caggcgtttg agcatatgac aagccggttc cggaccgatg cagtgaagat tgccgccagc 946561 catatttatg tggcaggcgg aaaccaaacc gattcagagc ggccgattga agtcggcggt 946621 gcatacacgg tggctgctga aagcctgccg gcagatgccg cttacgttgc gctcggccat 946681 ttgcatcgcc cgcaaacgat caagcgggcg cggacgcttg cgcgttattc aggatctccg 946741 ctcgcctaca gcttttctga agcgggctac gctaaatcag tgacgattgt ggacgcaaag 946801 cctggggaag aggccacttg gcaagaggtg ttattatcaa gcggcaagcc acttgtgaag 946861 tggaaagcgg caaatggatt aagtgaggtg tacagctggc tggatgaagg cagagatcag 946921 aatgcttgga ttgacttgga aatccgtgtc gcggaccagc tgtcacttga agagattcac 946981 aggctgcgga aggcgcaccc gggctttatc catatcaggc cggtttttga agaacagaac 947041 aaagaccggg aacggatcga ggttaaacat gtctcaatcg aggaccgctt taagaaattt 947101 tatgaaaaac aaactggcgg tgcggtgccg gatgaagaaa tggtgaagct gtttttagag 947161 cttgcatcag gcgttgaaga ggaggatgcg aaatgaagcc gatcgcctta agcattaagg 947221 ggctccacag ctttagagag gagcagacga tagattttga aggcctttcc ggtgccggtg 947281 ttttcggcat tttcggcccg acaggaagcg gtaaatcctc tatactcgac gcaatgacgc 947341 ttgctttata cggaaaggtg gaacgggcgg cgaataatac gcacggaatc ttaaatcacg 947401 ccgaagatac gctgtctgtg tcctttacct ttgcgcttca gacgaatcac caaatctcat 947461 acaaagtcga gcgtgtgttt aagagaacgg atgaaatgaa ggtaaaaacg gcactttgcc 947521 gcttcatcga aatcaaggac gagcatacgg tgctggctga taaagccagc gaagtgaata 947581 aaagagtgga ggagctctta gggctgacga tcgacgattt tacgagagcg gtggtgctgc 947641 cccaagggaa atttgctgaa tttctgtctt taaaaggggc agagcgcagg catatgcttc 947701 agcgtttatt taatttggag caatatggag acaggcttgt gaaaaagctg agacggcagg 947761 cgcaggaagc caatgcgaga aaaaatgaaa tgcttgctga acagtccggt ctcggtgagg 947821 cgagctcaga ggcagtggag caggctgaaa aggttctcga acaagctgaa gcccggctgg 947881 aagcgatgag gaagaaccgt gatcaggcga aggagcggtt tacagagcat caggagatat 947941 ggaatgtcca aaaggaaaaa tccacttatg aagaagagga aaaacgtctc gcagaagaac 948001 agccgcatat agacagcatg caaaaacgcc tgctggaagc agaaacagca gcagccctta 948061 agccctatgc ggaccggtac gcagaagcga tccagcatga ggagcaagct gaaaaggaac 948121 aaacgctagc ccaaaaggat ttagcagacc ggacagcttt ctttcagcaa aaacatgaag 948181 agtatgaagc gtggcgccag cataaaagcg agaaagagcc tgagctttta gccaaacagg 948241 aacagctttc acgcttgcag gaaatcgaaa tcaaactgag tgaggccaag caagaggaag 948301 agcgcaaaaa ggctgacctc cggcagaaag aagaggctct tcaatctgtc atgaatgaat 948361 tagagaccgt aacagaccgc ctgacacgag ggcaaaacag acagacagaa ttgaagcagc 948421 agctcaaatc cctgcaggtg acatccgatg agcgaaaaag ctgccagcag gccgcagaga 948481 tggcattgcg catcagacaa accgaggaac aaatcaaaaa agagaaaaaa cgaagtgaag 948541 aattgaacct cgtgctgcag aagatgaatg aagagaagaa tacactcgtt caaaagacgg 948601 aagcggaaga aaacaacatc attcaggcat atgaggcagt tcaaactgtg taccatttgg 948661 tgtgcgaaac ggaacgctca ttaacacgta tgacggaaga ggctagaaag agtcaacaca 948721 cgcttcactt acagcgtgaa aaagcaaggg tggcactgct gacaaaagag ttagcccaaa 948781 agctgactgc cggaaagcct tgcccggtat gcggttcaac cgatcatgat ccatctgcct 948841 cggtacatga aacgtatgaa gccgacagcc atcttgaaga ggacatcaaa cggacagatg 948901 tgttattgac ggaagctgca gctctcagcc aggagattct ttcagccaaa attatgcttg 948961 aagaacagtc cgcgcgcttt attgaacagt gtccgttttt gcagacaatt caagcacaga 949021 accttgaagc ggcagcttcc ttcgaacatc agccggtgta tgaagcattt gaaactgcca 949081 aatttgaatg gaaacgaatc aagcaggaca ttctttctgt taagacacga atggcacaaa 949141 tgattggcgc ctatcaggag tctttaaaaa aggccgagca gcttaatgaa aaaatcggtt 949201 ttgaaaaaag agaagccgac cgtattgaaa gcatcatcag tgagcttcaa tcctcaatgg 949261 acagcagtct gaacatgttt aaagaagcat ttcagaatca atctgtggac gaagcagaaa 949321 aatggcagca agccattgaa gaaaaggacc gggctgcaga agaatgtgaa aaacgaattg 949381 agaagagtat cgcgtttctt gctgagcatg aagcacaaaa ggaaaaactg cgggaatcgg 949441 gacaccggct tgagcgggaa aagctggagc ttcattatgc ggctgaacgc atcaagagcg 949501 tgatagctga ttatgagcac gaactcggag attatgcaaa aggagattcg attcaaatca 949561 aactccgctc tgtccagcag gatctaaagc tgttaaagga aaaagaacaa tctttatatg 949621 aagaactgca aagcgcccaa atgaagctca accaagcgaa aagccgcgct tctgcaagcg 949681 agctcactct tcaagaggcg aagggcagat tggaaaaagc aaaagctgct tggcttgagc 949741 atacaaaaaa cacctccatt acccggactg aggaggttga acaaagtctc atcccagctg 949801 atgaacttga aaagatgaaa accggcatag accagtttat ggataaactg aagcaaaatg 949861 ctgcaaactt aaaacgagta gcagagatac ttgccggcag agcattatca gagagcgaat 949921 ggaacgaaac cgttgcagca ttacaagaag ctgaggacgc atttggcgct gctatagagg 949981 aaaaaggcgc ggccgcaaaa gcactggctg tcattcgcga ccatcataaa cggtttaatg 950041 aaattgaagc tgaactgaaa aaatggcaga tgcatatcga caggctggac aagctgcaag 950101 ctgtgtttaa aggcaatacc ttcgtcgaat ttttagctga ggagcagctt gaaagcgttg 950161 cgagggacgc ctcagcaaga ctcagtatgc tgacaagaca gcgctatgcc atcgaagtag 950221 attctgaggg cggcttcgtg atgcgggatg acgcgaatgg aggcgtacga cgcccggttt 950281 ccagtttgtc tggaggagag accttcctca cctcgctttc acttgctctt gcgctgtctg 950341 cgcagattca gcttcggggg gaatacccgc tgcagttctt tttcttagat gaaggcttcg 950401 gcacactgga tcaagatctg cttgatacgg ttgtaacggc cttggaaaaa cttcagtcag 950461 acaacctggc tgtcggtgtc atcagccatg tgcaggaact gcgtgcacgg cttccgaaaa 950521 agctgatcgt ccatccggct gaaccgagcg gccgcggtac gcgggtatca cttgagttga 950581 tgtaagggag gagcggatat ggcaaagcag attgccggaa tatgtgagct gtgcggccgg 950641 agcgatgtcc agctgacaga gcatcatctt acaccgaaag aggaaggcgg aacgtttttg 950701 ccgacagcga tgctctgtat tccttgtcat aaacagattc atgccttata taccaatcaa 950761 gagctcgctg tacgtttaaa tggaatggct gaactcagaa gcgatccaga gcttgcccgg 950821 tttgtcaaat ggatcagaaa acagccgcct gagaagctga tcaaaactaa gaaatcaaat 950881 gaacgaaaaa agaaaaaatg actaaaaagc agccctctct ttgcagagcg gctgctttta 950941 tccgtttcca accatatccg gaagcaaaag ttgttgttga aaagtaacca aaaagcggtg 951001 ctcgatgcac cgctttttta tttgcgcccc cgttggactg ctgtgtacat aatggatcgc 951061 tttccgtttg aagccgtcca ttcaaaacgg tctcctgtcc cttcgctgct gtagttgtag 951121 tgatgctgca tcgcgcattg tgcggtgtca tttgaaaagt gataaaagga cacaccctgc 951181 cccgccgaag tattcgaaaa gactccttta ttataagaaa agacgcaatc gaataccgat 951241 aagccgaagc tgtgcaagtg ctgcagaaat gcgagaaagg tttcgtcgtc aagcgaatcc 951301 aaaagcgcca tgagcggccg cttgactgat ttctcatagc ggatgcgttc tccgccggaa 951361 agggagatgt tttctgcacc gcatgccaaa accaacttgt cctgaaagcc ggcttgctcc 951421 cactttcctt tatgatggat ccagattggg ctgtgttgga gactgtccgc cagcagtata 951481 tcgccttcac cgttttcgat taagcagatg ccgtcttcaa tgaggatggt gccgtattcc 951541 cactttcgtt cctctgtata taacaattgt ttccgtttca tccatgctgt ctcctttttc 951601 ttcattcctc tcttttcttt ccaattcaag cctgtcccat acaactcttt tatggacaaa 951661 tcaactatct gcctatagat gcataaactt actaaggtgc tgaaagaaac gaaattgtta 951721 cgaaagaaac gggattggag ctgatgtcac atgtgtggaa ttacgggttg ggtcgatttt 951781 aaaaagcagc tcgtccagga aaaacaaacg atggacagaa tgacagacac tctttccaaa 951841 cgagggcctg atgattcaaa cgtttggggg gagcaccatg ttttattcgg acataaaaga 951901 cttgcggttg ttgatattga aggcggacgc cagccgatgg cgtgtaccta taaaggcgat 951961 acgtacacca ttatttacaa tggcgagctt tataacacgg aagatttgcg caaagaattg 952021 cgggcgcggg gccatcaatt cgagcgtacg tcagataccg aggtgcttct gcacagctac 952081 atcgagtggc aggaagactg tgtcgaccat ctcaatggca tattcgcttt cgctgtgtgg 952141 gatgaaaagc gtaatctgtt gtttgccgcg agagaccgtc tcggtgtaaa gccgtttttt 952201 tacacgaagg aaggctcttc atttctcttc gggtcggaaa tcaaagcaat cctcgcgcac 952261 cctgatataa aagcgcgagt ggacagaacg ggactttctg aaattttcgg tcttggaccg 952321 tccagaaccc cgggcactgg catatttaaa ggcataaaag aaatccgccc ggctcacgcg 952381 ctgacatttt ccaaagacgg acttaatatt tggcgttatt ggaatgttga aagcgaaaaa 952441 catacggaca gttttgatga cacggttgcc aatgtcagat cgttatttca ggacgcggtg 952501 acgcggcagc ttgtgtcgga tgtgcctgtt tgcacattcc tatcaggcgg tctggactca 952561 agcgcgatta cagcgattgc ggcgggccat tttgaaaagg aaggaaaagc accgcttcat 952621 acttattcga ttgattacga agagaacgat aaatattttc aagcaagcgc ttttcagccg 952681 aatgatgacg gaccatggat tgaaaaaatg acagaggctt tcggcacaac gcaccacaaa 952741 tgcgtcatca gccaaaaaga cctcgttgat catttggagg aagctgtact ggtcaaagac 952801 ttgccgggaa tggcagatgt cgactcatcc ctgctgtggt tttgccggga aatcaaaaag 952861 gactttgtcg tcagcctatc gggagaatgc gcggatgaga ttttcggcgg gtacccgtgg 952921 ttccatacgg cagatgttga gtctggcttt ccatggatga gatcaacgga ggagcggatc 952981 aagctgcttt ctgactcatg gcagaaaaaa ttgaatctga aagaatacgt aaatgccaaa 953041 tatgaagaaa ccttggcaga aacgccatta ttagacggag aaacgggtgt ggataaagca 953101 agaagacagc tgttctattt aaatatgctt tggtttatga cgaacctttt ggatcggaag 953161 gatcgcatga gcatgggggc gagcctggaa gtgcgggtgc cgttcgccga tcaccggctt 953221 gtggaatatg tttggaatat tccgtgggaa atgaaaatgc atgataatcg ggaaaaaggc 953281 attttgcgca aagcgcttga gggcattttg cctgatgaca ttttgtatcg caaaaaaagc 953341 ccatatccga aaacacatca tccggaatat acaaaaggcg tcagcgagtg gctgaaaacg 953401 atcagaagcc aaaaggactc cgtgctccat accttactgg acagaaaaca attagatcag 953461 cttttagaaa cggaaggctc ctccttcaag gtcccgtggt tcgggcagct catgaagggg 953521 cctcagctga tcgcccatct tgctcaaatt catacatggt ttgaagcgta tcgcattgat 953581 attgacgaga ggtaggttca atacaaatgt gattaaaagc cagagatgta tagatttaaa 953641 taagaaggat agatgagcag ggaaatatat gctctatcta tccttttttg tacaacagca 953701 ctatcgaatt gcccccgcat tccttcaata agaatgaata ggttttaatg ttctgccgat 953761 aaaactagct gataccgggc ttaactttaa ttccctagcc catacagaaa gttgaccaat 953821 atggtgaatt tcgtgagcga tgatatggtg taatatttca tctcgcgtat ataaaacacc 953881 tgtctcccaa ggaacgctta caagttcatc ttttatttga tctgaatgtg tttgtaaaac 953941 atcaattatt tcagttcgga atgtatttga gagagatttc actttattga gtgtttgata 954001 atcagcgaac tgaacagcga tatcttcttt tccttggata gcacgaatcc aactatattc 954061 cacatcaata atatgaaaaa gggtatataa aatattctct actccgccaa gacgattttt 954121 aagtaattct tcagtggtta gttgatgaca ccaagtaaac cattgatctc taacctgcca 954181 gttatattca aaaaatttca tcactaaact cactccaata ctatcatgta tcataacaat 954241 tagccctttt ttccgtgatt cctctattaa tgaagtgatg attgagaaat gtttacattc 954301 tacctgttgt atggcattaa aaataataat gcatatctcg tcgatgatgc tgtgcgtctt 954361 gttactttta caaagtaaga atcggcattt tcttcatata caattaggaa aaaacatact 954421 agacttgaag aagcagtgat acataggagt gagaaaatga aagagataaa agaagcttac 954481 cagcaatgcg gacagattgt tggcgaatac gcgccagcct gtttcaaagc attatcatat 954541 ctcccgctaa agcaaagaca agcctcttgg gcagtattgt cgttttgcca cacggcggcc 954601 agtgcagacg aaaaggtatt gcccgcattt gaagctaaag ctgatcatgt ttaccaaagg 954661 acaaataacg gtaaacaaca tctatggaag gcttttgatc atgcgtatcg gacctttaca 954721 ttggaaagcg aaccttttcg ggagtttatt gccgcacaaa aagaagacgc caagccgtat 954781 gatgaccttg atgaactgct catgtacgca tatcggacgg gcggtgctgc cggattgatg 954841 ctgctgccga tactgacacg ccgaaaacaa gatcagctca aacaagcagc cgtctctctc 954901 ggcttggcca tacagctggt tcgcttctta agtgatcttg gcacagatca gcaaaaaaac 954961 cgcattcccc gtcaggtaat gcagcaattc ggctatacag aggctgatct ccaaaaaggc 955021 accgtaaata aagcgttcac aatgacgtgg gagtatatcg cttttgaagc agaagcctac 955081 cttgaagagt gtcaggatgc cttgccgcta tttccgcagt attctcaaaa aacggtgaaa 955141 gccgctcttc atttgcaccg ggctgtttta gaaaaaatcc gggcgaagca gcacgatgta 955201 tttcaatatc acttcgctct cacagagacc gaagtgaagc agattctgtc tgatatctaa 955261 aaaacacccg gccttgattg agccgggtgt tacgccatac ctttttgaat ccagatacgt 955321 gagcgccatc ttctgtacat taagattccc cggacccatt catccgcgat aaaagaaatc 955381 caaatgccgg caagaccgaa accgaggtgg atgccgaaaa gataagcaag cgggaggcca 955441 atgccccaca ttgaaatcat tgccatgtaa accgggaatt tcgcatcccc cgcggcccgc 955501 agagagttaa tgataatgac attaaacgag cggcctggtt caaggataat ggtcatggca 955561 atcaataggc ttgcagttgc tataatgtca gggctttgtg tgaagagtcc gatcaggtct 955621 tttgaaaaga tcgtcatcaa aacagaggta gccgcagcaa ttccgagtgc ccaatataag 955681 ctcttcatgc agcgctcata agcggcatca aattgtttgc cgccgatata acggccgatt 955741 aagatttgtg taccctggct gatcgcagtg ccgaacagca aaataaacat cgtaatattt 955801 tgcgtataca cttttgttgt caacgcctgc gcgcccatga tggcgataaa atacgtgact 955861 atcatttgcg acaggttgta tgaaagctgc tctcccgcag aaggaatgcc gattttcagc 955921 agcttgcgca aatgctcttt atgcatatga aagacttttt tcagcgacat cttcagctgg 955981 atgcgtttgt tgacaatcac aatcatcgcg attaatccga tgacgcgggc gatagatgtg 956041 gacatggcca caccggcaac accgagaaca ggaaagccga acaaaccgaa aatcacaaca 956101 aagtttccgg caatgtttaa aatgttcatg ccgatagtga caaacattgt atcttttgtg 956161 tagccgtagc tttttaagat cgcgctgaat gtcatgatta aagcctgaat aaaggacaga 956221 cctccgacaa cttgtaaaaa gactttcgca tcaggcatca gtgcgtctga taatcccatc 956281 atatgaagca gagggacagc cgcgaaaaag acgacggcgc tgatggccag gctgatgaag 956341 aagttggcgc cgattgacac ataagcgact tccatggctt ctttcttttg ccgtgagcct 956401 agaaattgtg aaatgataac ggtcgttcct gttgcgataa agctgaacat cacgataatt 956461 aaatttaaaa tctggttgct gacgccgact gctgccacgc tgttatccga gtattggctg 956521 agcatcagtg tatcggcatt acccataaac atatataatg agacctcaat aaagatcggc 956581 caagtaagcg aaaataatga gaacgttttg tcagcgggtt ttttcaaagc agttgatttg 956641 aagacagctt gtttcatcgt gtctaacccc tttcgtaaat aaaatcaacg ttttaaagtg 956701 tacctccatt tccttataat aaaaagggat agaaacgata cttcttgtaa aaatccgact 956761 taaaaaggag gatgattcaa atgcctcgca tcctgtttac agtcccgcct tttccggtat 956821 ttatcgcagc tggggaaggg gtttttaaaa aaggagaaac ccatgtgaaa cgtgtattct 956881 ccgtgtttga tctgatatat gtcaaacagg gaacgttata tataacggaa aatgaaacat 956941 cgttttctgt tgaaggcggc gagtacatct tgctttctcc cggtcttgaa cactacggga 957001 cgaagggcag tgatgaagca acctcctact attggcttca cttcgatgaa catcgatatg 957061 aatttacggc aaagggaggc agcaactggt ctgagcttca gcaggaaaaa gggagcttcg 957121 aagagctggc ccgctacgga ttggccttgc cgagaaaagg caaggtgcag cgcccgcagt 957181 ttatggcgca gcagtttgaa aagctgatcg attactccgc ggaaaactct gatttgccgc 957241 tcagaaagca aattttattt gaggagctga tgctgcatct tcaaaaagaa gcgttccaaa 957301 taccgtctgc gaaagagcgg gtagcctggg aggcggcccg gtatttacag gagcactata 957361 aggaaaagac gacaatcaag gatctgtcgc tcgcccttca ctatcatcag gattatgtga 957421 gccgctgcat gcagcaggtg ctcggcgtaa ctccggcaca atacacgaac cgggtgagaa 957481 tgacggaagc gaagcgtctt ttatcctcta caaatgataa aatgggcgtt attgcggaaa 957541 cggtcggaat ggaagatccg acatactttt caaaactctt taagcagata gaaggcattt 957601 caccaattga ataccggaaa attgtcagcc ggaaagttca ataaccagac gagggatgaa 957661 catgaaaaca acaatttacg atgtggcaaa ggcggcgggt gtttcgatca caactgtgtc 957721 ccgtgtgata aacaatacgg ggagaatcag cgataaaaca cggcagaagg tcatgaatgt 957781 catgaatgaa atggcataca cgcccaatgt ccacgccgcg gcgttaacgg gaaaacgaac 957841 gaatatgatc gctctcgtgg cgcctgatat ttcaaatccg ttttacggcg aactggccaa 957901 aagcattgag gaaagagcgg atgagctcgg ttttcaaatg ttgatttgca gcaccgatta 957961 cgatccgaaa aaagaaacaa agtatttttc tgtgctgaaa cagaaaaagg tggatggcat 958021 tatttttgca acagggattg aaagccatga cagtatgtct gctttggagg aaatcgccag 958081 tgaacaaatt ccgattgcca tgatttctca ggataagccg cttcttccga tggatattgt 958141 tgtgatagac gacgttcgtg gcggatatga ggctgccaag catcttctgt cactcggcca 958201 cacgaacatc gcctgcatta tcggagacgg gtcaacgaca ggcgaaaaaa atagaatcaa 958261 aggcttccgt caggcgatgg aggaagcggg cgtgcccatt gatgaatcac ttatcatcca 958321 gacgcggttt tccttggaaa gcggcaagga agaagcggga aaattgctcg acagaaatgc 958381 tccgactgct atttttgcct tcaacgacgt attggcttgt gccgccatac aagctgcgag 958441 aataagaggc ataaaagtgc cggatgatct ttctatcatt ggttttgata atacgatact 958501 cgcagaaatg gcggctccgc ccctgacaac cgtagcccag ccgataaaag agatggggcg 958561 gagcgtcatc gaactgctgg cagaagcaat agagggaaaa cgaaaggcga aacaaaaaat 958621 agtgctcccg cctgagcttg tagtcagaca ttctacatca ccgctcaaca catgagcccg 958681 ctaatgagcg ggttttttca ttatgacagt tgaagccaaa aaaacatatt gcgtgtaaac 958741 caaaggcggt gtaaaatata accatctttt gagaaagcgc ttgcgcaaaa tggcagagcg 958801 gatagaaccg ctgttttttt agctgttaag agaaaacgct ttctcaaagc gagcccgaaa 958861 tgagataaag gagaggatgg gacgtggaac atcaagtaag atgtgcagta ttgggattag 958921 gaaggctcgg ttattatcat gcgaaaaatc tcgtcaccag tgtgccgggg gcaaagctgg 958981 tttgtgtcgg tgatccgtta aaagggagag cggagcaggt tgccagagaa ctcggtatcg 959041 aaaaatggtc agaggacccg tatgaagtgt tagaagatcc cggcattgat gctgtcatta 959101 tcgtaacgcc gacaagcaca catggtgata tgatcatcaa agcagccgag aacggcaaac 959161 agatctttgt tgaaaaaccg ctgacattaa gccttgagga atcaaaagca gcttctgaaa 959221 aagttaagga gacaggtgtc atctgccaag tcggctttat gagacggttc gatcccgcat 959281 acgcagatgc caaacggcgg atcgacgctg gagaaatcgg caaacctatc tattataaag 959341 gctttacgcg cgaccaaggc gcgcctcccg cagaatttat caaacacagc ggtggaattt 959401 ttatcgactg ttccatccat gactatgata ttgcccgtta tttgctaggg gcggaaatca 959461 cttctgtttc aggacacggc aggattctga acaatccgtt tatggagcag tatggcgatg 959521 tggatcaggc gctgacgtat attgaatttg actcgggcgc agcgggggac gtcgaggcaa 959581 gcagaacctc tccatacgga catgacatcc gggcggaggt gatcgggaca gagggcagta 959641 ttttcatagg gacattgaga catcaacatg tgaccatcct atcggctaaa gggagcagtt 959701 ttgatatcat tccagacttt caaactcgtt ttcatgaagc ctactgcttg gagcttcagc 959761 atttcgccga gtgtgtccgg aatggaaaaa caccgattgt gactgatatt gatgcgacga 959821 tcaatttaga agtgggtatc gccgcaacca attcctttcg aaacggcatg ccggtacagc 959881 tagatgtgaa gcgcgcttat acaggtatgt aaaagctaag tatgttgcat ttgaggcttt 959941 ccgcaaaaaa agcaagggca ttttagccct tgctttctct tttctcatat aaatagtaca 960001 tataatcagt aggtacgcct gaatggtcca gctgtctcag catggcggtt acgttccctc 960061 tgtggtaagt gccgtgattg acgacatgca ggatggtgtc tgcataggtt gattccagtg 960121 tacctagttt cggatgctgc attgtgaagg tctgttctaa gtccgtctgg cggctgaaga 960181 aatcatgata ctgtgactcc agctcggcag cgtgctgttt aatcgctgcc atattacctt 960241 gcgcggactg taatttgcct gcgctgtcta taatctcttg gtaggccact cccgaaagaa 960301 cattcagcca aatgtagtca gccctgcaca tatgaagcag cacgtcgctg acagaaggaa 960361 atacgctctt tacttcttga taggcagttt cctccggcag gttttcgata tgggtaaata 960421 ttttcttgtt tgcccaagaa tgatagtcat aaaactgttt tgcatcagtc atcagcatgc 960481 ccccttttct aagaaattcg tttttttcat ctgtttctcc ttcaattgca aaagagtgac 960541 accccaaaat atcctgccgc tgcccacatt accgctgcag agcatttgtt tacgatcagc 960601 ataagcctgc cgctcgtatc tatcgtctga aacaaccggc ccgctattgc aaggctgatg 960661 aaccaaatcc aagacacagc gatgcaggcg gccataaaga gccatttctc aagccccgaa 960721 tattgaagag agctcgtgcc gatgacgccg atcgtgtcca gaatggcatg cgggtttaaa 960781 agagaaacag cggccgcaaa cgcagcttgc ttttttggtg tgaacgtatg tttctcattt 960841 tggcttgtgt tcggacggat gttccaagtc acccagccca tataaagcaa aaataaaaat 960901 ccgccggcca tcatgactgt ctcaaacaca ggcagctcct gcacaatgac agacacgccc 960961 gcaacggcta atacaattaa caaggtatcg cagactgaag cactgatgac agctgggaga 961021 gcccgccaaa tatgcttttg caacgcgcct tgctgaaaaa taaacacatt ctgcactccc 961081 agcggcaaaa ttaagccaaa cgcgagcaca attccgtgaa tgattgcatt catgctgaaa 961141 aagctccttt cacatttttt ttcaatcata agagagattg tcactaaagt ctccagccat 961201 ttggttgggt taggaaccag ccaaatgtat aatgtgtaaa aaaggggggc atgaccttgt 961261 cgcaatggca gccaagccga aagtcggatg ttccgctgca tcggcagatc gaacaatata 961321 tgaaagacaa gattcttcac ggagagtggg ctgtagggac gaaaatcccc tcacagagaa 961381 cgctggccga catgtttcaa gtcaaccgca gcacagtcac agcagccata gatgaactca 961441 cgtctcaagg cttgttagag ggaagaaaag gcggcggtac gaaggttgta aacagtactt 961501 ggagcgtgct gacggctgag cctccgcttg attggagcga ttacgtccgt tcgggcattc 961561 atcgcgccaa ttcttccatc attcaagcta ttaatcagaa cgaaccaaga gcggatatca 961621 tcagattagg aactggagaa ctttcaccgg atcttgtgcc tgctgacaca attggacgga 961681 tgtttcagca aatcaatccg ggcgtcctgt ctttaggata tgagcagccg aaaggaaacc 961741 gtcagctgcg ggaggcagtg gccgaccatt taaaaggaaa gaagatccat gtgtcaccgt 961801 ctgcaatttt aattgtgtcc ggtgcacttc aggcacttca gctcatctca attggacttt 961861 taaaacgaga ttctgtcatt ttgacggaga agccgtccta ccttcaatcc ttgcatgtat 961921 ttcaatcagc tgggatgcgg cttcgcggct tgccgatgga tgatgaaggg gtcaaagcgg 961981 ggcttgtttc ttctaatcga aaacaatatg gaggacagct gctttacacg attccgtcgt 962041 ttcataatcc gacaggcaca gtcatgtcag agcagcgaag gaaagagatc atcagcctgt 962101 caaaaaaaga gcagatgccc atcattgagg atgatgcgta cggtgattta tggtttgaag 962161 aaaaaccgcc gcagccgttg aaagcaatgg atcatgaggg caatattctg tatctgggcg 962221 cgttttcaaa aacggttagc cccggtctgc gaatcggctg gcttgccggt ccggagccgg 962281 ttattgaaag gctggcggac attaaaatgc agacagacta cggatcaagc ggcctgtccc 962341 agtgggcggc tgccgagtgg ctgtcacagg gatattatga agagcatctg acttgggtac 962401 gcaggaagct taaagaaagg agagacgccg ccgttcattt tctcgagcgg tatgccgggg 962461 acattgccac gtggcggatt cccgcaggcg gcttttatat ttgggtgaca tttcacaaaa 962521 acctgcctgt cagccgtttc ttttatgaat tgctgaaacg gcaggtgctt gtgaatcccg 962581 gctatattta tgacggtgaa gaccgaaaca gcatcaggct gtcatattcc tatgcatctc 962641 ttggagattt ggaaactggc attaaagcgg cagctgaaac agcacgccgc ctgatgatgt 962701 cctaggcttt ggttatacga tgacagctcc cagtgccctg gcgaaggcaa tcgcgtgctc 962761 aggtgcgatt ttgcagcctt tcaatttgtc gagggagaca tgaagctgtt caaaacggca 962821 cgtgctgatg tccatgtttt gaagggacgt gccggtaaag ctggcgcctt ccaattcgca 962881 tccgtcaaag tgtgtctgct ggagcaccgt atcgctgcat tcactttgca taagagcaca 962941 gtgatcaaat cgaacttgtt tcatatttga gtacgaaaat gagctgaaat gtccgtggca 963001 ttcctcgaat gaaacattcc gcagcgttgc ttccgccaca ttcattccaa ccatttttga 963061 ctgcttaact gaagttctgt gaatgacagc cccgctgaaa tcggcgtttg ataaatcgca 963121 tttttcaaag atcacatcgg tcagttcaat atgccgaaaa gacacatcga taaagacgac 963181 atttctgaat accgtttttt caacacatag tctttcgata tcttcgccgc agatggtgca 963241 atcttcaaac aaatgcatgc tgattacatc atcctgtgtc acggcatcat gaaaatctgc 963301 ggtttgcagg ttttccggta tgttcggttt ttgaattgcg attttattca tgtgatgaca 963361 tcctttgctg cccgaaaaac agaggcttcc gggttcaatt taatagatcg ttaaggaaat 963421 tgatacatat agtaaatcgt gaagagcctt ttcttggtac agcagcccgc ttgttttgta 963481 agcataaatg gaaagcttcc tatacgtcaa ggcgtttaca ggccgaaaaa gccaaaggga 963541 acaggaggaa tgcggaatgg ggcattacat caaaaccgag gagcatgtga cactgtttgt 963601 agaggatatc ggacatggaa ggccgatcat ctttttgcac gggtggccgt tgaatcataa 963661 gatgtttgaa tatcaaatga atgagcttcc gaaaagggga tttcgtttta tcggcgttga 963721 tttgcgggga tatgggcaat ctgaccgccc ttgggaaggc tacgattatg acacgatggc 963781 cgatgatgtg aaagcagtca tttatacgct gcagcttgag aatgcgattc ttgccggttt 963841 ttcaatgggc ggcgcaattg caatccgtta tatggcaagg catgaaggag ccgatgttga 963901 taagctgatt ttactgtctg cggcggcccc cgcgtttaca aaacgcccgg gttatccgta 963961 cgggatgagg aagcaggata ttgacgatat gattgaattg ttcaaagctg atcggcccaa 964021 aacactggct gatttaggga aacagttttt tgagaaaaaa gtgtctccag agcttaggca 964081 gtggtttctc aatctgatgc tggaggcttc ctcctacggg acgatccact cgggcatcgc 964141 attaagagac gaagatctca gaaaggaact tgctgcaatc aaggtgccga cgctgatcct 964201 gcacgggaga aaggatagaa ttgcgccgtt tgattttgcg aaagaattga agcgcggcat 964261 caaacagtcg gaattggttc cgtttgcaaa cagcgggcac ggagcatttt atgaggaaaa 964321 agagaagatc aacagtttga ttgcgcagtt ctccaactca taagaaaaaa cccgacattg 964381 atcgggtttt ttatataatt cctctgtttt gcagtgcgtt aatgatgaga tcagctccat 964441 cggaaataga ggtctggtca gactcaatga tgaaatcggg tgaaagcggc gcttcatacg 964501 gagaatcgat cccggtgaaa tgtttgatct ctccgtttcg cgctttttta taaagccctt 964561 ttggatcgcg ctgttcacaa acatgcagcg ggcacttcac ataaatttcg aagaactcac 964621 ctttaggaaa gagcgctcta accatgtccc gatcctctct gaatggagaa ataaaagccg 964681 ttaaaatcat ttgcccgctg tcgacaaaca gcttcgccac ttctccgatc cggcggatgt 964741 tttcaatcct gtcaccagtc tgaaatccaa gatctttgtt taagccgtgg cggatattat 964801 caccgtcaag cacgtagctc tgaatgccct tgcggtaaag cttttcatcg acagcattgg 964861 ccagcaccga ttttccggag ccggacaaac ctgtaaacca aaggacgcag cttttgtgtc 964921 cgtttaagga ctgtctgtca gactttgaga tggcagcggg atgccaaatg atgttcggat 964981 tgtgtgtcat tgcaattccc cgctgttttg cttgatggca acaggctgtt ggtgaagtcc 965041 cttgatcagc acggctgcga cctcaggccg gctgaattct ttaggcggct ttttgccttg 965101 gcggagaagc tctctcactt ttgtgcctga taagtggatg tggtctctcg ggctgtgcgg 965161 acatgttttg gaggtgccca tgtttccgca ttttcggcaa taaaagctgt gctcaaaaaa 965221 cagcggcttg atgcccagct cttcctctgt gaatgattga aaaatatttt gggcgtcgta 965281 tgttccatag tagctgccga cacccgcgtg atcacggcct acaataaaat gggtacagcc 965341 gtaatttttt cggacgagcg catggaaaat cgcttcccgc ggacctgcat aacgcatggc 965401 ggcagggaaa accgataaca tgacacgatc ctttggataa tagtgattaa gcaaagcctg 965461 gtagctctcc attctgatat cgctggggat atcgtctgac tttgtttctc cgacaagtgg 965521 gtgaagcagc agaccgtcga ccgtttctaa cgctgttttt tgaatgtatt catgcgctct 965581 gtgaacaggg ttcctggttt gaaagccgac aatcgtcttc cagccgagtt tttgaaaggc 965641 cgctcttgtt tcagcgggcg ttgcataaaa ctgttcgaaa gatttgtcag gcaggctgct 965701 gaccgtgata ggccctccga tatagtaatc cgggcgcgcc agcaattttt ttacgcctgg 965761 gtgggcagga tcgtttgttt taaaaacaga cagtgcttct tgtgttttat caggctggta 965821 tatatcggtg actgtgatca tgccgtaggt aacaccgtct ttcacaagct tgacgtgatc 965881 tccggcagac agctgtcttg ctgttttttc tccgacaggc agcgtaatcg gcaggctcca 965941 cggcaagccg tttgccagcc tcatctcttt cacaacggaa tgataatctt tttctcccaa 966001 aaaacctgtt aacgggctgt agccgccgat cgcaataagc tccagatcac tcagtgcaag 966061 ctgatccagc tctgcttggc acgcgcaccc ttcaaaatgg catgcgggat cacagcggtt 966121 gattaatacc cctccgtggg gttcgtttcc attcaacgtg ttcaacctcc atttatacgt 966181 ttccttgttt tcttttctgc acttaatgaa agtttgacat cagcgcctta acatcatttc 966241 gattctcaca tcaagaacct gccatccgct attcttgatg caggccgcat tctgttttct 966301 cccgtccggc ccatcttcca gccctctcat cgttcgggtc cggggaaggc agtgtacaca 966361 tttcacagcc tatgctcgga taatgttgat cgtgcagttt gttataaggc aaattgtgca 966421 ggcggatgta cgtccaaacg tcatcccatg tccagtggat aagcgggcaa attttgatga 966481 gctcaaactt ctggtccagg tttacgtatt gaatatgctt tctcgttggt gactgatccc 966541 ggcgcagtcc tgaaatccaa gctgtcatgc cggacaggtg ctttttgagc ggttcgattt 966601 tccgcaattg gcagcagagg ttcgggttat gcttccacag ctctccgccg tacttcgtcc 966661 cctgttctgt taagctcagc tcgggttcga gcatctggat tgcaaatccc ggatatcgtt 966721 ctttgacggt ctcgatcagc tcatatgttt cctgaaaatg aagcccggta tccaaaaaga 966781 tgatgtgtgc gtttttgttg atttttgata ttaagtcgag aagcaccatt ccttctgcgc 966841 caaagctgca ggcgtacaca atcttttctc cgtacgttcg gtaagcccat ttcaacacat 966901 cgagctcatc gatcaattga tccgttatct gtttggacag catgtcgttc caagtgtcat 966961 atgtgatggt ttcgttcaat gttttccccc cgtttgcatc tgcttttttt atctattgat 967021 cgagttatag gcagactatt cattttttgc ataaaggttc aggttttagg tgccgcgccc 967081 gcctaaaatg aggtgcggaa ccattaagag cccggctgaa tatgcttttt agcaaaatgg 967141 ttttatgccc aaggagaggt agtatgccga ttgccattta tcaggggcat catcattcgc 967201 ttgccccggc ggacattaac atcgtcattg atgtcatcag agcctttacg gtcgcccatt 967261 atgcgtttat cggcggggcg aaagagattt tgttggtccg gacagctgat gaagcctttg 967321 cgctgaaaga cacctatccg gattatgttt tgacgggaga ggaaaagggg gtcggtatca 967381 gcggatttga tttagataat tctccaaaac gtatggctgg gcagaatatg acggataaaa 967441 gcctgatcca gaaaacaaca aacggcgtca cagcagcatt gggggcgctg aacgcaaagc 967501 atctgttcgt aactggattt tccaatgcca aaacaacggc acagcatgtg aaaaagctcg 967561 tcgcaaacga ttgtgtcata aacatagtgg cttcccatcc atccggtgat gacgatatgg 967621 catgtgcgga gtatatcaaa ggcatcattg aagggacaaa tgtggtaacg gctgcggagg 967681 cgattgaaag aataaaaggc tcttctgttg cggagaagtt ttttgactgc cgccagccat 967741 tgtttgattc ggaagacatc gtttactgta caaaagaact gacgggcgat ttcgtgatga 967801 aagtgaaaca agatggagaa gttccaacga tagagagggt cataatatga atgatttttc 967861 actagaattg ccagtgagaa caaacaagcc gagagaaacc gggcagtcca ttttaattga 967921 taacggctat cccttgcaat ttttcaaaga tgcgatagcc ggagcgtccg actatattga 967981 ttttgtgaaa ttcggctggg gcacatcatt acttacgaaa gatcttgaag aaaaaatcag 968041 cacactgaaa gaacatgaca ttacattttt ctttggcggc acactgtttg aaaagtacgt 968101 aagccagaaa aaagtgaatg aatttcatcg gtactgcacc tatttcggct gtgaatatat 968161 tgagatttca aacggtacgc tcccgatgac aaataaagag aaagcggctt acattgccga 968221 tttttctgat gaatttcttg tgctcagtga ggtgggcagc aaggatgcgg aattagcaag 968281 ccggcaaagc tctgaggaat ggcttgaata tatcgttgag gatatggaag cgggcgcgga 968341 aaaagtgatt acagaagcca gagaaagcgg aacgggaggg atctgttcca gcagcggcga 968401 tgtcaggttt caaattgttg acgacatcat ttcctcggat attgatatca acaggctgat 968461 ttttgaagcg cctaacaaaa cgcttcagca agggtttatt caaaaaatcg ggccgaatgt 968521 gaatcttgcc aatattccat ttcatgatgc catcgcgttg gaaacgctgc gtttagggct 968581 aagatccgat accttttttc tgtaaaatag cggctgcggg gctctcgtcg tgaagagagc 968641 ctctgcctat tattttttat ggcggtacat aggcgtgaga tagggaagtg aggtcaggcg 968701 gatgttgtag atgaagtcga tgactcttgt cgatatcacc tggcatatga gggcttgaat 968761 gacgatgccc cagtcaataa tagacgcggt gaccataaaa atgatgcaat tcatgatgag 968821 caggatcgtt ccaggattcc cgccgcggta gatagaaatc atcagagcaa gggctccgaa 968881 tcctccgttc gaaattttat atttgtataa aagtccgatt ccgagtccca ataacactgc 968941 gccgcttgcc agatcaagcc acaggttaga tgtgatatca ggaaaaactg catcaaagat 969001 caataccgag acagaggtga cggtgataga agcgagggtg ccggtgaatg ttctcatctc 969061 cagccatttt aaagcggtaa aaagcattga tacattcaca gcccacactg aaaatccgtg 969121 ggggatttga aacagataat gcaatagcac cgcaatacct gctgcaccgc ctgtcggaat 969181 atcatgcgga aataaaaaca aggacatgcc gagtccttgt agtacgccgc ctacgacaat 969241 cataaacgta agttttgctt tcatcagcag ttcagccatt aagtcatttg ctcctttatg 969301 aaaagacttg tccgctgttt tcattttatg aggctgtcca ttatttatgt ctcaaaataa 969361 agaaatggcc cagcttaata ggctgagcca tcccacttgt agcgattgac gatctccata 969421 ttgatctctg tgccaatgcc ttttcctttc gggatgtgga ccattccttt tgaaggctgc 969481 aggctgacga gatctgtaaa aggattctcc atgacgtccc actcgatcgg ttcaatgtga 969541 tcgttcttca ttttagacca tgggggcaga caggcttgtg caaataaagc atagagccgt 969601 gagagcgatc cgtcatatgc atgggcggat gctctgacgc cgaaataacg cgcgagctgg 969661 aggcagtccc gaaactcatc aattccgttg acatgcatga catcgggctg aatgatatcc 969721 aaacagcgct gtgaaaggag aggcacatat tgcgccgggc ctttcatgtt ttctccgccg 969781 gcaacaggaa cagacaaacg gcttcgaagc atagcgtaat cctgcggctg atcaaagggc 969841 aaaggctcct caagccagcc aatgttcgtc cattcggaga aatagcgctc ccatttaaaa 969901 gccgcagcgg catcgtagct ttggtttgcg tccagaatca tcgtaatgga gctgcctgct 969961 gtatgctgca gcgcattgat gtgccggaca tcctccttga atgaagtccc gccaattttg 970021 actttgattt gctcaaaacc ttttttcaac tgggcttcaa cattggagac tgagcggctg 970081 atccattgcg gggagtctga gtacgattga aaagacgcgt acacaggaat ctcctctctg 970141 tatcgcccgc cccataattc gcaaaccgaa caatccgcag ctttggctgc aatctctgtc 970201 agcgccatgc ttacagcgga ggccgcccgc tggtgccatt tttgaatcgt gcgcactaat 970261 gacaggcggc tgccagcctg ttttcctaat agaaatggga tgatccgctt cgtaaaaccg 970321 acatggagag cagggagcca atcaacgcat tctccccagc cgtctatccc gctttcggtg 970381 ataatcctga tgagataaca agtccgatat cgtttaaacc cattggcatc tccgtatggc 970441 ttttctaatc gatgaaatag cggaaaggtt tcaatccgta caattttcac actgggtgct 970501 acctttcctc agcgggctgg agccgattgc cagccatttt agggtcttct ttttcttttg 970561 tttcttcatt gttttgcttc acatggatga gcatcatcac aagaatcccg acaacgagag 970621 tcaatcccgc gatgcttaaa aacatgccgg gtctggacca ttgcatcagg cggccgaaaa 970681 tcggaggacc gatcgctacc cctaagaaac gtacagagcc gtacagcgag gtgacaaatc 970741 cccgtctttc tttgccgaca gccccggtaa tgaaactgtt cacacaagga aggacaagac 970801 ctgagcctat actgctcagt acaagaacac tgataaaaag gacaagattt tcaatgaatg 970861 acagtgccgc gtaggatacg gtcatgaacg ccaatccaag tacgatcagc tttttcatta 970921 acgattgctt ttgcccgatt ttgcttcctg ttgtatagga cgtcacacac ataaccaaaa 970981 gcgggatcgc taaaattaag ccttttttca cgccgtcggt gtcgtatgtt ttttcaagaa 971041 catctgagag ataaaacagg atgccgaata aagtaaacaa acaggtcgca ccggctaaat 971101 aagcggtaaa cagccatctg ccttcatgtt taaagacact taacagccct tttgcatatt 971161 gtccgattgg tggcggttct ttttcctttt tcttttcttt aataaaaatc caagtcagta 971221 cgatcgaaat gatacaaaac acaggaaagg caaaaaacgc gccataccag acaagcaggg 971281 cgatcagcga gccaatgatc ggcgatagca ctttccccat gccgtttgaa gcttcaacaa 971341 ggccgagcac cttgctctcc tgggcgcctt taaacagatc tcccgtcagt gccatggcaa 971401 ttgggccggt tccggctgcc ccgattccct gtaacgctcg tcctgccatg acccaaggat 971461 aggcattgtc aaaaaaacct gccgcaaacc cggctaacaa accgccggca ccatacaaaa 971521 ttaagcaggg aataatgatg actttccttg agaatcggtc tgcgagataa ccgacaatcg 971581 gaatcgcaaa tgctgcaatc aaggaaaata ctgtgatcac gagactgact tgaaattgtg 971641 ataaatgaag ttcagatttc atttttggca aaatcggaat aagcatcgag tttcctaggg 971701 ttaatattaa agggattgaa ccgattgcca caatcgtcat tccgttattt tgttttgatg 971761 attccatctc agagcacact ccttttcttc tgcttagaat gtccctgatg gcttcgttta 971821 ttcagcgatc agacagcaaa aaaccgaaca gaagatacct gttcgggaaa aaagagggtt 971881 aaccgagagc ctgtgaaatc aaagcatata agtgtccatt ttgaataggc gcttttttct 971941 gatagaacaa aatcggaggt tcatcatctt tatgaaatcc catttctatc aggctgtcat 972001 gcagagacgt gtgttcactc ggtatatcga ttcgcatcgg cccttgtttg ccggccgcca 972061 gccttgtaat tatctgtgct gcaacatctg atgatggagc gatgataggg ccgaatttca 972121 aattggccgg tgtctgtaca gaaagtccgt agccaatgag ctgtccgtcc tgatttctgg 972181 cgatgataca ttcgcatgaa gcagaaataa gctgctgcaa aaggtttgat cgatctccgc 972241 caaaggcagc cagatccgcc gcggttaagt cgtgaaagtc ttgttctcta aaggatgtca 972301 gttcagcatc aagctttttt gtataaggtt gaaaactgtg acagctgtac tttcgcactg 972361 aacctgccgt atgaaaacct gctttttcat aaagcggcaa accttctttt gtggcgcaaa 972421 gcctgatggc ggtgttttca tccgtttggg taatacaggc gtttaccata cgccggccaa 972481 gaccgagccg ttgatattcc ttgtcaacga taacaaggcc gatagaagta agacggccaa 972541 acaaaaacaa gccgatgcag gaaataatat caccgctgac attttgataa ccgaaaaagc 972601 gtccctgctg aacaagcagt ttcagctctt gttcgccata atccggccac ccggcttgcc 972661 cgcaaagccg caataagccg gaaacgtgtt cttcatgaag cttaatcagt tcatctacta 972721 cgtccataag atcacctgct tgttctaagt gttttgtaca tgacaatatg attgccaatg 972781 ccgggaatgt caaatggttc gccaagttcc ttccagccaa gcttggcata gtagcccttg 972841 acatggtgtc ttgcgttgca ccataccgcc tgaacgccgc tctccgccag tttgtgctcc 972901 gcgtgtttga tcagcgtgct tccagctttt tgatcgcgat atccctcgag cgttgccatg 972961 cctctcagcc gatacgcaga ggcttccgtt aataaaggct gactttgcgg ggaaaaagaa 973021 gcgatgctga tcagcgttcc atcataaaac acgccgagat gaaaggagcc ttctgcgtga 973081 tcctctttat atttgcattg ttcgatggat tgatggggac gcagaatgcg atgccggatt 973141 tcatatgtat cttccacgga aatggttttg acttcgagca taatgttcct cctcatgatt 973201 gtttttctat atcgtaacac gaatctcgtt gaaaaagact gcccgattcg atcaggcagt 973261 cttttggaaa ttaatgcaaa aagatatttt ggcgctgctc atctttttgc tgaatatatg 973321 atgtgagctc agcggttaag tcagatctga ggaaaggcgt tatcaagtag atgccgttaa 973381 acagctcgca tgccgtatcc agcagggagc gtgcaattgc aaggccttcc gccttttgct 973441 tttctttatc ttcaccggca tgggccattt tttcgcgaat cgtatcagac agcttaatgc 973501 cgggaatttc attatggatg aattcggcat tccggctgct tgtcagcggc atgatgccga 973561 tatagatcgg cgtcttcaga tgttttgttt cgttatggat atcgacaagc tgctgctcgg 973621 aatagacagg ctgagaaaca aaataatctg cgccgcaatc tatttttttc tcaagccgtt 973681 ttaccgcttt atccagatgg cggacgttag gattaaatgc ggcggcaact gagaaattcg 973741 ttttcttgcc gagcggtttt ccagacagag acagaccttc attgaattgt ttgatcagcc 973801 tgattaaatc aaaagatgtt aaatcatata cagacgtcgc cccaggaaaa tccccgattt 973861 tagaagggtc acctgtaata gcaagcacgt cattcagccc taacgtatca aggcccatta 973921 aatgtgactg taagccgata atgttacggt cacggcacgt aatatggaca agggaacgca 973981 tatcgagctg ctgcttgaca agggcgccgc aggcaacatt gctgatccgc ggggtcgcca 974041 aagaattgtc ggcgagtgtc agggcatcga ttcccgcttc ttttaattca gcagcagcgg 974101 acagaaattt gtcaaagctt agttttttcg gcgggtccag ctctacgata atagagcgtt 974161 ttttcgctgc gatctcatcc aggccgggct cggttcgctc gtgatgaaca gaaatgaatt 974221 ctttcgcccg ggttttgact tctttttccg taatcggagc cagcccgcca accgcttccg 974281 ccatcgccct gatgtgattc ggcgttgtgc cgcagcagcc gccgataatc cgcgcacctt 974341 gcttacggaa ttctgacgcg ctgttttgaa aatacgtgtc gtctgtttca tagacgagcc 974401 gtccctcttc aagcgaagga agactgctgt tcggataaac ggataagaat acgtcatcaa 974461 aaatcggcac ttcgcttagc gcttcaatca tgtgataagg gccgaggcgg cagttaatgc 974521 cgacaatatc agctccgaga tccgcaatcg agcgcaatgc gtcagaaagc ggcgttccgt 974581 cctgcaatac gccttgctcg tgcatggaga cattgagcat aatcggaaga tcagtctctt 974641 tgcgcgcgat tttcagcact tcacgggctt cttccaaatc ataatatgtt tctaacagca 974701 agccatccgg ctcttcatgc agcagcagat acagctgctc gcggaagctg cgcttaattt 974761 cgtcaagact gtatgcgttt ttattaaatg tgcgtatgcc gcccatcgtt ccaagcacgt 974821 atgcatcgcc tgctgaagcc cgcgcgatct ttacggcctc ctgattcatt tttttgatgt 974881 catcctcaag cccgtgtctg gataatttaa tatagttggc tccgtacgta ttcgtttgaa 974941 taatgttggc tcccgcttca acgtacgctt tatgtatgcg ctgaatttcc tccggctttg 975001 aaatattgag ctcctcaaaa cacctgtcaa tgccatagga gtagaggagc gtccccatgg 975061 cgccgtcacc gattaacacc tgtctttgca aatcttctaa aagtcccatt gtctgcctcc 975121 tttattcaca tcagcaagga aaaaagagaa ataaaaaaag tcctcttaag aagaagactt 975181 tgtcagtgat tttgtctctt cttatcttcc aagctgttcg agcttgctgg atttagcacc 975241 ttggtcatgg ctgatcgcca ttacaccggt tgctgaagct tcgtcgggcc agtccctctg 975301 cttctcttga taagaacgga tatgaaattt tcgtgtcagg aagtgccaaa agatatctgg 975361 cgtttttccc tttctccaaa tttaccgaaa ataaagacaa taatcaatag gaatcagaaa 975421 atttatctga aatttataaa ttgaacgtca attggcagat ctgctccccg tacagctgag 975481 ataatctgct gcaggtcatc tttgtttttt ccggtgacac gcacttgatc atcctgcacc 975541 tgagacttta ctttcagtcc ggagtttttg atgatcgtat tgattttttt tgcgttgtcc 975601 ttgtcaatgc cttgaacaag ctttgcacgc tggcgcaccg ttccgcctga cgcgttttca 975661 accttgccgt aatcaatgtt ttttgtcggt acgtttcgtt taatcaattt gctgaccagc 975721 acatctttca gctggcttaa tttgaattcg tcatcggaaa cgaggaccag ctcctcttta 975781 tctaaagaaa tgtcgctttt gctgccttta aagtcatatc gggtactgat ttccttcagt 975841 gcgatttgga ttgcgttttg cacttcaggc aattccacct tggatacaat atcaaatgaa 975901 ctttcttttg ccatatgaaa acctccataa catttaactt atgtgttgat tatagtagaa 975961 taaagagaaa cttccaacag aacaaagaat caatttgtga tgattggaaa aaatgttaac 976021 aaaatccgca gagaataagc ggaacaggaa ggacgatagc atgagaccag ggcagcaatt 976081 aaccttgagt atagatcacc aaaccgactt cggttacttt ttaaccgatg gggaagatac 976141 gattctctta cataacagtg aaatgactga ggatatcgag gacagagacg aagtagaagt 976201 ctttatatac gtagaccagc aggaaaggct tgcggccacg atgaaaattc cgatcatcag 976261 cgcggatgaa tatggctggg ttgaagtggt ggataaagtg gaagatatgg gcgttttcgt 976321 tgatgtcggt ttatcgaagg acgcactagt cgcaactgag catttgccgc cgtacgaaga 976381 tgtctggccg caaaaagggg acaaacttta ctgtatgctg aaggtgacga accgggggcg 976441 catgtttgcg aaaccagcgc cggaagatat catcagcgaa ctgtttaccg acgcttcaga 976501 agatctgatg aataaagagc tgacaggtac ggtgtacagg ctgatcgcat cgggttcatt 976561 cgtgatcacg gatgacggta tccgctgttt tattcacccg tcagaaagaa aagaggagcc 976621 aagactgggt tcaagagtca caggccgggt gattcaagtg aaagaagacg gttcagtcaa 976681 cttgtcgctg cttccgagaa aacaggatgc aatgtcagtt gatgctgagt gcattctaac 976741 gtatatgaga atgagaaacg gtgccatgcc gtacagtgac aaaagccagc ctgacgatat 976801 cagagaacgt tttaatatga gcaaagccgc ctttaaacgc gcgctgggcc atttgatgaa 976861 aaacggaaaa gtgtatcagg aaaatggatg gacatacgag aaaaaatagc atgaaaacgg 976921 ctcgcctgca gcagactgcg gagcgagccg tttttttatg tctagtttaa ttcatcaacc 976981 agcggccaac tatatcatat taatttgcca aaatcgtgtt caaatatttg ttttaaggga 977041 aaacataata aagaagaaag agcggaggaa catgccatgg tactagatca aacaaaaaaa 977101 ttactcatcg tcatcatcgg cgctttactc aatgctgccg ggctgaactt atttttgata 977161 cctgcagatg tatatgccag cggatttaca ggtgttgccc agcttttatc aagcgtcgtt 977221 gatcaatatg ccccctttta catatcgacg ggaacgctct tgttcctctt aaacattccg 977281 gtcggtattt taggatggct gaaggtcggc aaatcgttta cagtgtacag cattttaagt 977341 gtcgcactca ctactctgtt tatggggatc ctgccggaaa caagcctgtc acatgacatt 977401 ttgctgaacg cggtgttcgg cggcgtcatt tccgcagtcg gtatcggctt aacattaaaa 977461 tacggagctt cgacaggcgg gcttgatatc gtcgccatgg tacttgcaaa gtggaaggat 977521 aaacccgtcg gcacgtattt cttcattctg aacgggatta tcatcttgac ggcaggatta 977581 ttgcaaggtt gggagaaagc attatatacc ctggttacac tatatgtgac aacgagggtg 977641 atcgacgcca ttcacactcg ccacatgaag cttacggcaa tgattgtgac gaaaaaagcg 977701 gacgaaatca aggaagccat ttacggaaaa atggtgcgcg gcatcacaac tgttccggca 977761 aaaggagcat ttacgaacga acagaaagaa atgatgatta tcgtcatcac gaggtatgaa 977821 ctgtacgatt tagaaaagat cgtcaaagaa gttgatccaa aagcatttac gaacatcgtt 977881 caaacgacag ggatttttgg tttctttaga aaagactgac gaaagcaggt ggaagtcgtg 977941 aaacggctgc ttgtgatgct cctccccgtg ctgcttttga taggctgcgg gaaagatgag 978001 cagacagaac ccgataagga ggtatcaggc ggaatggaga atcaagaggt tgttttatct 978061 attgacgcaa ttcaggagcc tgaacaaatc aagtttaaca tgtcgctgaa gaaccaaagc 978121 gaacgtgcta ttgagtttca attcagcaca gggcaaaaat ttgaacttgt cgtgtatgat 978181 tctgagcaca aagaaagata ccgttattcg aaagaaaaaa tgtttacgca ggcttttcaa 978241 aacctgacgc ttgaatctgg agaaacatat gatttctctg atgtgtggaa ggaagtccct 978301 gagcccggaa cctatgaggt aaaggtgaca tttaagggca gggcggaaaa tctcaagcag 978361 gttcaggctg ttcagcagtt tgaagtcaaa taagaggcta tggcgagtcg ccatagcctt 978421 tttttattgc agtttgtcca gctgattttg aaattgatgc aactgttgac gttccgcatc 978481 tgtcgaattg gcatacgcag aagatacagc atttttggct ctcagaatcg cttgctcctg 978541 atcgccttcc tcaaagccgt ttgtcaccat gaccgcctgt tgaacaaatg attttgcctg 978601 ctgaaacagt tcatttctca tttaatattc atactgcctt tcagccgagt ctcgtgccgc 978661 ggcatgctgg tgagcttctt ctaaagtaga ccgatatgga aatcttgcgg cgtgtagccc 978721 gatggagtct ttaccctgct gaataaacct tctggatttg cttcgtttac ccattttgag 978781 actgccccct tccatacttt gacgagatga gtcgtcttca atagtatggt ggggtaaagt 978841 aaggtttatg agtgggaaaa attaatacgg accttcttta aagtgagaaa tattctttca 978901 aaaaccttgc cacgccgtcc tcttcatttg tggccgtagt tcggttggca atctgcttga 978961 ccgcgtcaat tccatttccc attgcaacgc cgcagcctgc aaattcaagc atttccaaat 979021 cgttatcctc atctccaaaa gcaatgatcc gctccctcgg cacgccgtaa taatcgctga 979081 ttttctgcag gccgaccgct ttattcatgc cgcttttgat aatttcaatg acatgccaag 979141 gagcggccca tcttctatgg tcgatcacct cggcatgcac atccgataaa tatgagcgta 979201 ttgccggcac atcctcttcc tttgcatgta tgagtacgga cgtcacatct tcaccgagat 979261 tttcccgcaa gtctccgacc gttacatttg ttgtgttcat gttaaaggca tctatcaggt 979321 gctcatcatg gtaatgaaag tatacgtcgt caatcacttc agcaagcacg ttatgtacgt 979381 tgtagctctc gctgatatcc acgagctgtt tgacaacatc aagcggcagt gacgtatgat 979441 accgtcccca gctgtcgtct tgcggatgat ggacaaatgc tccgttaaaa ttgacaattg 979501 gcgttgtcag ctccatctgc tggtagtaca tggaacttga acgatacgga cggcctgttg 979561 agatgcagac ataatgcccg tcatctttta ggcgctgtat cgtatgaagg gtgttttcag 979621 atatggtttt atcatccttt aataatgttc catctaaatc taatgcgatt aaatagggtt 979681 ttgtctccat gaaaagctcc tttaacctta gattttgctt gttttgcctt acttacagtg 979741 tagcttttta ccatctttat tgtctacatg ttacacttat gattatggtt atcctaagga 979801 ggggcacatt gtgatacaaa ttgagaatca aaccgtttcc ggtattccgt ttttacatat 979861 tgtaaaggaa gagaacaggc accgcgctgt tcctctcgtg atctttatac atggttttac 979921 aagcgcgaag gaacacaacc ttcatattgc ttatctgctt gcggagaagg gttttagagc 979981 cgttctgccg gaggctttgc accatgggga acggggagaa gaaatggctg ttgaagagct 980041 ggcggggcat ttttgggata tcgtcctcaa cgagattgaa gagatcggcg tacttaaaaa 980101 ccattttgaa aaagagggcc tgatagacgg cggccgcatc ggtctcgcag gcacgtcaat 980161 gggcggcatc acaacgcttg gcgctttgac tgcatatgat tggataaaag ccggcgtcag 980221 cctgatggga agcccgaatt acgtggagct gtttcagcag cagattgacc atattcaatc 980281 tcagggcatt gaaatcgatg tgccggaaga gaaggtacag cagctgatga aacgtctcga 980341 gttgcgggat ctcagccttc agccggagaa actgcaacag cgcccgcttt tattttggca 980401 cggcgcaaaa gataaagttg tgccttacgc gccgacccgg aaattttatg acacgattaa 980461 atcccattac agcgagcagc cggaacgcct gcaatttatc ggagatgaaa acgctgacca 980521 taaagtcccg cgggcagctg tgttaaaaac gattgaatgg tttgaaacgt acttataaag 980581 cactaagtta ttaacaagag ctgaatttac gttatactgt agaaaaaagg agtgagggaa 980641 cgtggaagaa gcattaaaag aaaacatcat gggcgccctg gaacaggttg tcgatcctga 980701 gcttggcgtt gatatcgtga acctcggctt ggtatatgac gttgatatgg atgaagatgg 980761 cttgacgcac atcaccatga cgctaacatc aatgggatgc cctttagcgc cgattatcgt 980821 ggatgaggtg aaaaaagcat tagcggacct tcctgaagtg aaagacacag aggttcacat 980881 tgtatggaat ccgccttgga ctagggataa aatgtccaga tacgcaaaaa ttgcgcttgg 980941 cattcaataa aacaaaaaag gacagcctga catgtgaggc tgtccttttt tacagctgaa 981001 aggagtgaaa ggaaatgatg tacctgctgg cagttttatg cccgccgctt gctgttttgt 981061 tttcgggaaa accgtttcag gccttgctga atctcatatt gacctgtatc ttttggctgc 981121 cgggcgcgat tcacgcctgc tttatcgtcg ccgaccgccg tgccgaaaaa cgggcaagaa 981181 gataatttgg aaaaatgagg acgcagtcat ggtataatgg tcataaaaac agcagggaga 981241 gcactatgaa aaagaaattg cttgcattcg cgctttgtac tggcgcgtat gcggccctgt 981301 ttgcgtactc tgtgaactca gagcaaaaaa cagccacaag cgagatgacg gatgtcagcc 981361 gcctgatgcc tgtaaaaata aagcagacag tgaaagggca ggaagaggaa atgctcattg 981421 acacagtcaa agaggcaaat cgaaaaaaca taaaaatttc aatcgccggg gcccagcact 981481 ccatgggcgg ccatacatat tatgaggacg gcatcgttct cgacatgacg ggctacaaca 981541 aaatcctgtc actcgatcaa gagaagaaaa ccatcagggt gcaaagcggt gcaacgtgga 981601 atgatatcca gaaatacgtg aatccatacg gactcgcggt aaaagtcatg cagtcacaaa 981661 acatttttac aatcggcgga tctctcagcg caaatgcaca cggacgtgat attcgctacg 981721 gctcgctaat tgatacagtc aaatcattcc ggcttttaaa agctgacggg atgattatca 981781 ctgtcactcc aaaagatgat ttgtttacgg cggtcatcgg agggtacggc ctttttggcg 981841 tgattcttga tgtaacgctt gagctgacag atgatgagct gtatgtcatg aagacagaaa 981901 aaatgaatta cagcacatac tcagactatt tttcaaagca tgtaaaagga aatccagatg 981961 tccgaatgca tctggcgcga atttcaacag cgaaaaaagg atttctgaaa gacatgtatg 982021 tcacgaatta cgtattggct aatcatcagg atcagctgtc ctcatacagc gaacttaaag 982081 aagacgagta tacgggagcc acaaagtttg cactcggctt gtcaagacgg tatgaatggg 982141 ggaggaattg gctgtgggac acacagcaat cctatttcct gagccagaac ggcacagaga 982201 tttcacgcaa taacgtcatg cggtccgaat caaagtttct tgagtatgaa aacaatgaca 982261 acacagatgt tttgcaagaa tactttgtgc ccgtgaagga gtatgggtcc tatattgatg 982321 acctgagaca aacgctgtcg gacgaagatc tgaacctgct gaacattacg atccgctacg 982381 tgcagaaaaa tgaaaaggcc gacctttcct atgcgaagga cgatatgttt tcgctcgtac 982441 tattaataaa cgagggcttt tcaaaagaag accaggcaga taccgcccga atcatcaggc 982501 gcatgacaga cgttgccatc aagcacggcg gcagctatta tctgccttat atgacctacc 982561 agacaaaagc gcaaatgaga caggcatatc cgaaaagtga agcgtttttt cagaaaaaac 982621 gaacctatga cccggatgag cgctttatga attactttta tcagaggtat aaataatggg 982681 gaaaaacaaa ttaaaatggc tgacattatc acaaagcagc gtgtttttcg caagcagctt 982741 aatctttccg ttttatattc tgtttgtgaa aaatatcggc tcaagctaca cacagttcgg 982801 tttttcctac ggattgttcg ggttgagcgg agcgcttatt tacccgctcc tcggacggct 982861 gtctgaaagg tttgacagcc gttattttct gcttctgaac tcgtggggga tggctgttct 982921 gcttttatat gtcccgcata tcggaagcgt cgttcaagtg tatatcgtcc aagtgctgtt 982981 agggctcttt ggagcgatgc aaaagcatgg agaaaaagtg ctgatcgcta attttacaga 983041 cagtggagag cgtggaaaga agatcgggaa ttaccatttt tggacagctg tcttttcagc 983101 agcagccatt atgctcgggg gctttctcgc tgactttttc acagtgcaaa tgatttttta 983161 tgcaagctct attctatatt ttttgagtgg attgatgatg atgaaaacag gctgacgcgg 983221 tcagcctgtt tttttatgcg gctgaaatgc ggcaccgcat caacgttttt gtgctggagt 983281 cgtgctgatt ttttttgagc ggaattccca ttgaacagaa aatttataaa tgaataaaaa 983341 tattaaatat acgattgaat taatttttat tcatgttata atgttaaata atttcacaaa 983401 gaccaagagg gtgaacttgt tttgaaaata ggaattgtag gtgctacagg atatggaggc 983461 accgaacttg tcaggattct ttcgcatcat cctcatgcag aggaatgcat actttattca 983521 tccagcggag aagggaatgt ctatagcgag ggttatcctc atcttaccgg cttagcggat 983581 cagcagctga agccgattga tatgaatacg atcaaacacg aaatagatat catgtttctc 983641 gctgcgccgc ccggagtatc aagtgaattg actccaaagc tggcagacgc gggaattacg 983701 gttattgatc tgtcaggtga tctgaggata aaagaaccgg ctgaatatga aaaatggtat 983761 aaacggacag cggcaccgaa ggcggtgatt caagaggcgg tatacggtct ggcagaactg 983821 aatcaactgc aaattcaaca ggcgaaactc attgccaatc caggctgttt tccaacagct 983881 gttttgcttg gcctcgcgcc attggctcaa aagaaactgc tcgatgaatc tttcgttatc 983941 gttgacgcga agaccggtgt ttccggagcg ggaagaaaag catccatggg aactcatttt 984001 tctgagctga acgacaattt taaaatttat aaagtcaatg aacatcagca cacgccggaa 984061 attgagcagg cgctgaatga atggcagcca ggtctcgggc ccattacatt ttcggctcac 984121 ttggttccga tgacaagggg catcatggcg acgatgtata ccagattaac ctgtgaccta 984181 accgcagatg acctgcatga tttatattcg gaattttacc aagattcata ttttgtgaga 984241 gtgaggccaa aaggtcagta cccgcaaacg aaagaagtgt acggcagcaa tttctgtgat 984301 atcgccgtga ccctcgatga gagaacgaac agagtcacga tcgtctcggt aatcgataat 984361 ttaatgaagg gtgccgccgg tcaggcagtg caaaacttta atttgatgaa tggctggaat 984421 gaagaaactg gactcaccat cacgccaatt tatccataga acgggagaga atcgaaccat 984481 gattcagtta agtgaagatc aaattgtaaa agtaacaggt gatgtatcct cgccaaaagg 984541 gtttcaggca aagggtgtgc attgcggact gcgctactcg aaaaaagacc tcggcgtcat 984601 tatcagcgag acaccggccg tgagtgcagc agtttatacc caaagccact ttcaggctgc 984661 tccgatcaaa gtgacacaag acagcttaaa gcacggaccg acactgaaag ccgtcatcgt 984721 caacagcgcc attgccaacg cctgcacggg agaacagggc ttaaaggacg catacacaat 984781 gcgggagagc tttgcttcac agcttggcat tgagccggag cttgtcgctg tttcatcaac 984841 gggtgtcatc ggcgagcatt tagacatgga aaaaatccac gcggggatcg aactgctgaa 984901 agaaacacct gcgggatcag gcgattttga ggaagcgatt ttaacaactg atacggtgat 984961 caagcagacg tgctatgaac tggcaatcgg cggcaaaaca gtcacgatcg gcggagcggc 985021 caaaggctct gggatgatac acccgaacat ggccacgatg ctgggatttg tgacaactga 985081 cgcggcaatc gaagaaaaag cgctgcaaaa ggcgcttcgg gaaatcactg acgtttcatt 985141 taaccaaatc acagttgacg gagaaacatc cacgaacgac atggtattag ttatggcgaa 985201 tggctgcgcc gaaaacgagt gcctgacaga agaccatcca gactggccgg tctttaaaaa 985261 agcgctcttg ctcacttgtg aggatctagc taaagagatt gccagagacg gagaaggcgc 985321 gacaaaacta attgaagccc aagtacaggg agcgaaaaac aatcttgatg caaacgtcat 985381 tgccaaaaag attgtcggct caaatcttgt aaaaacggca gtatacggaa cagatgccaa 985441 ctgggggcgg atcatcggag ccatcggaca ctccgcagca caggtgacgg cagaagaagt 985501 agaggtttat cttggcggcc aatgcctgtt taagaataac gaacctcagc cattctctga 985561 atctatcgcc aaggaatacc ttgaaggaga tgaaatcacc attgtcatca agatggctga 985621 aggggacgga aacgggagag cgtggggctg tgacctgacc tatgactata tcaaaattaa 985681 cgcgagctat cgcacgtaat aaaggggagc gaaatgaaga aaacaatcgt ttttaaatgc 985741 gggggaagcg tcatccgtga gctgtcggag gaattttatc aaaatctgaa agagctgagg 985801 gcgtcaggct ggaagctggc aatcgtacat ggcgggggac cggaaatcac aaatatgctg 985861 aaacggttaa atatcaagac agagttttcg ggcggacaga ggaaaacaac gaagccggtg 985921 ctggaagtgg cggaaatggt tttatccggt tctgtcaata aatttttcgt tgctgagctt 985981 gccaaacacg gactgcgagc cgcgggcatt tctggtaagg atggcggtct tttggaggct 986041 gattatctag atccggaaac atacggagaa gtgggagaaa tcaaaaaagt cgatgcgtcc 986101 atggtgaacg cgctgatgga aaatggcatc atccccgtta ttgcgccgct gtctatgaca 986161 agcgactgca aaacgctgaa tgtaaatgct gatctggctg cttcagcagt cgccggagcg 986221 cttgaagccg ataagctgat gttcgtcacg gatgtcgatg gaatcatgaa ggaaaagcag 986281 cgtctggacg tcctgacccc taaggagatt cagatgctga tcaagcagga agtgatcaca 986341 ggagggatga tcccgaaggt caattcagcc ttgtcagctt tatcagatca ggtgtctgaa 986401 gtcatgatcg taaacggtaa aggatcattc ttcgcagaac aaacctttca agggacaaaa 986461 attgtcaaag caaaggaggc tgtttcatga gcagcttgtt tcaaacctac ggccgttggg 986521 atattgacat caaaaaagca aagggaacgt acgttgagga tcaaaacggc aaaacgtacc 986581 ttgatttcat tcaggggatt gcggtatcaa atctaggaca ctgccatgaa gcggtgacag 986641 aggcagtcaa aaaacagctt gacagcgtat ggcacgtatc caacctgttt caaaacagtc 986701 tccaagagca agcggcgcag aagctggcag cgcatagtgc gggagatctt gtctttttct 986761 gcaacagcgg cgcggaggcg aatgaaggtg cgataaagct tgccagaaaa gcaactggaa 986821 aaacaaaaat catcactttt cttcagtcgt tccatggccg cacgtatgca gggatggctg 986881 cgaccggaca ggataaaatc aaaacaggct tcggcccgat gcttggaggc tttcactacc 986941 tgccatacaa tgatccttct gcttttaaag ctcttgggga ggaaggcgat attgccgcgg 987001 tgatgcttga aacagtgcag ggagaaggag gagtcaatcc ggcgagtgct gaatttttat 987061 cagccgtaca gtcgttttgc aaggaaaagc aagcccttct cattattgat gaaatccaga 987121 ccggcatcgg acggacggga aaaggcttcg catatgagca cttcggactc tcaccggata 987181 tcatcacagt cgccaaagga ttgggaaacg gctttccggt cggcgctgtc atcggaaaga 987241 aacagcttgg agaagcgttt acccctggtt ctcacggaac gactttcgga ggaaacatgc 987301 tggcgatggc tgctgtgaat gccacattgc aaattgtatt ccagcctgac tttttgcaag 987361 aggctgctga caaaggggcg tttttaaaag aacagcttga ggcagagcta aagagccctt 987421 ttgttaaaca aatccgaggt aaaggattaa tgcttggaat tgagtgtgat ggcccggttg 987481 ctgacattat tgctgaattg cagacattag gcttgcttgt attgccggcc ggcccgaacg 987541 tgattcggct gctgccgccg ctcaccgtga ctaaggatga aatagcagaa gccgtcagca 987601 agctgaaaca ggcaatcgct catcattccg ctgtaaacca gtgatttttt ttcgatataa 987661 aggcataaaa attcattttt ataattaatt attcatcaag aggtgggctg ttagatggaa 987721 ggttatttag tgttagaaga tgggacatcg ttcagcggcg agctggacgg tcatgaaaac 987781 tgcacgggag aagctgtttt tttcacagga atgacaggct accaggaagt gctgacagat 987841 ccatcatata agggacagat tattgtattt acctacccgc tgattggcaa ctacggcata 987901 aatgaaaagg attttgaaag caagaaaccg caagtaaaag ccgcggttgt ctatgaggcg 987961 tgtgatcact tttctcatta tgaagcggta tacagcctca aggagtatct acagaaatgg 988021 aatattccgc tgttaaccca tgttgatacg agggctgtcg tgaagaaaat ccgggcaaac 988081 gggacgatgg gtgcgacagt cacagcctct aaagaaggag ctgagattgc ccttcaacca 988141 gagaatgtgg cagagcaggc ttccgcccag gaaatcagca cattcggcga cgggaataaa 988201 catatcgctc tcattgattt tggctataaa aagtcaatcg catcatcact tgtcaaacga 988261 ggctgcaagg ttaccgtggt gccataccag caaatggagg ccgtatacaa catcaaaccc 988321 gatgggctat cgaacggacc tggagatccg aaagccattc agccatattt aggaaagatc 988381 aaaagcatca tcagccgctt tccgactcta ggcatttgtc tcggacatca gctgatcgcg 988441 ctcgcgtttg gagggaatac ttttaagctg ccattcgggc acaggggagc taatcatccg 988501 gtcatcgacc gtaagacgaa acgggtcttt atgacaagcc aaaaccacag ctatgtggtt 988561 gatgaacagt cgattaatga agaagagctc accatcaggt ttcatcatgt caatgatacg 988621 tcagttgaag ggcttgccca taaaaaactg cctgtcatga gtgttcaatt ccacccggaa 988681 gcccatcccg gacctgcgga aagcgaatgg atttttgatg attatctaaa gaatgtgata 988741 ccagcaagga gagaaatcgc gcatgcctaa agacaccagt atttcaagca tattagtaat 988801 tggctcaggc ccgatcatca tcgggcaggc ggcagaattt gattattcag gcactcaagg 988861 gtgcatcgcg ctgaaggagg agggctaccg ggtaattctc gtcaacagca atccggcgac 988921 aattatgact gatgaagcct tcgctgatga aatttatttt gagcctctga cagcagaaag 988981 cctgacagcc atcattaaga aagaacggcc tgatgggctt cttgccaatt taggcggtca 989041 gaccgcgttg aatttagcgg tggagcttga agaaacgggt gttttaaaag agcacggcgt 989101 caaactcctc ggcacatccg ttgaaacgat acaaaaagga gaggaccggg aaaaattccg 989161 ttcgttaatg aatgaattaa aacagcctgt gccggagagt gaaattgttg ataacgaggc 989221 cgatgccctc cattttgcgg aatccatcgg ttttcctgtt attatcagac cagcttacac 989281 attaggcgga aagggcggag gaatcgcccc tgataaagaa gcctttacag ctatgattaa 989341 gcaggcgcta ttagcaagcc cgatcaatca atgccttgtc gaaaaaagca ttgccggctt 989401 taaagaaatt gaatatgaag tcatgcgtga cagcaataac acatgcatta ccgtctgcaa 989461 tatggaaaat atcgatccgg tcggcgtgca tacaggtgac tctatcgttg tggcgccgtc 989521 acaaacattg acagacgaag actatcaaat gctgcggaca gcaagtctga cgatcatctc 989581 agcacttgat gttgtaggcg gctgcaacat tcaattcgcg cttgatccat tcagcaagca 989641 atattacgtc attgaagtga atccgcgtgt aagccggtca tcggctctcg catctaaagc 989701 gaccggttat ccgattgcga agatggccgc gaaactggca gtcggataca ctcttgacga 989761 gctgaaaaat ccgctcacag gctcgactta cgcaagcttt gaaccggcac tggattatgt 989821 gatcgtcaaa tttccgcgct ggccgtttga taaattcaaa aacgcagacc gcaagcttgg 989881 cacaaaaatg aaagccaccg gtgaagtgat ggcgattgaa cggaatttag aagcggcgat 989941 acaaaaggca gccgcgtcgc ttgaattaaa aaatatcggg acacaccttc cagagctcag 990001 cgggttgtca attgatacgc tatgggattt ggcaatcact ccggatgacc gcagattttt 990061 cgttgtcatg gagctgttga gccgcagcgt ctcgattgat gacatccatg aaaaaacaaa 990121 aattgatccg tttttccttc atacctttga caacatcatc aaattggaaa accgcctgat 990181 ggaagcaggg agcgatctct cttttgaatt attgaagaaa gcaaaggaaa agggattctc 990241 agacgcaacg attgcctcgc tgatcagcaa aacagaagaa gaggtgcgcg cgcttcgcaa 990301 ggagatgggc attacgcctt cctttaaaat cgtagataca tgcgcggcag agtttgatgc 990361 gaaaacaaac tatttttact ccacatattt cggagagacc gatggagaca tcagccgcaa 990421 agagaaaaaa cgcgcgctca ttatcggatc aggcccgatt cggatcggcc aaggcgttga 990481 atttgattac agtgctgttc acggtgtgct gacactgcaa gagcttgggt tcgaaaccat 990541 catgattaac aataacccgg aaactgtcag caccgattat gaaattgcgg accgcctgta 990601 ttttgaaccg atgacaacgg agcatattgt aaacgtggcg gagcaggaaa atattgattt 990661 tgcaattgtg caatttggcg gtcaaactgc aatcaatgct gctgaagcgc tcgaaaaagc 990721 cggcattact cttcttggca catcatttca aacgctcgac gtgttagagg atcgggatca 990781 attttatcag cttcttgacg agctgggatt gaagcacgca aaaggagaaa ttgcttatac 990841 aaaagaagaa gccgcttcaa aagcgagtga gatcggctat ccggtgttaa tccgcccatc 990901 ttacgttatc ggcggaatgg gcatgatcat tgttgactcg caagcccagc tttctcagct 990961 gctgaatgat gaggacagca tgccataccc gattttaatt gatcagtatg tgtctggaaa 991021 ggaagtcgaa attgatttga tttccgacgg cgaggaagtc tttatcccga catataccga 991081 gcatattgaa cgggcaggtg tccattcagg ggacagtttt gccattcttc ccggaccgtc 991141 catcacgagc gggctgcagc agggcatgaa agatgcggca caaaaaattg cccgaaaact 991201 ttcatttaaa ggcatcatga acattcaatt tgtgatcgac aatggaaaca tactcgttct 991261 tgaagtgaat ccgagagcga gccgcacggt tcctgtcgtc agcaaagtaa tgggcgttcc 991321 gatgattccg ctcgccacac gtctgctggc gggagcgtcc ttaaaagatc taaatccggc 991381 agttcaaaat catcatggag ttgccgtgaa gttccctgtt ttttcttctc atgcgatcca 991441 ggatgtggat gtcaagcttg gaccggaaat gaaatcaacg ggagaaggca tgtgtgtcgc 991501 atatgattct aacagcgcct tgaaaaaaat ctatacaaga gtctggagtc aaaaaggaag 991561 catttatttg caaaacgttc cggaagatgt gaaggagtta gcagaaaacg caggttttac 991621 aatacatgaa ggaacatttg cctcatggat ggaacaggaa ggaaactcgc tccacattaa 991681 tctgagcggt tctgaagaag cacgcaaaga acgtttggaa gccatgacgc acggcatccc 991741 cgtctttaca gaagaagaaa ctgtgcgggc gtttttacaa agcggttcag gccatccgca 991801 gcctgtatct ctcaaagacc tctataaaaa ggaagtggca tcatgcacac agtgacgcaa 991861 accagtttat acggaaaaga tttattaacg ttaaaggacc ttagtgaaga agatataaac 991921 gccttgctcg cagaagccgg tgagctgaaa caaaacaaaa ttcagcctat attccatggc 991981 aaaaccttgg cgatgatttt tgaaaaatca tcaacgcgga cccgtgtttc atttgaagcg 992041 ggcatggcgc agctgggcgg gagcgccctc tttctaagcc agaaagatct gcagctgggg 992101 cgcggtgaga ctgtcgctga tacggcaaaa gtgctgtcag gctatgtgga tgccatcatg 992161 atccggacct ttgaacatga aaaggtggag gaacttgcca aagaagctga cattccggtg 992221 atcaatggac ttaccgataa ataccaccca tgccaggcgc tggcggatct cttgacgatt 992281 aaggagataa aagggaagct taaaggcgta aaagtcgcgt acatcggtga cggaaataac 992341 gtggcgcact ccttgatgat cggctgcgcg aaaatgggct gtgatatctc gatcgcttca 992401 ccaaagggat atgaagtgtt agatgaagca gctgaagcgg caaagacata tgcacttcaa 992461 tccggctctt ctgtcacgct gacagatgat ccgattgaag ctgtaaaaga cgcggacgtg 992521 atttattctg atgtgtttac aagcatgggg caggaagcgg aagagcaaga acgtcttgct 992581 gtctttgcgc cttatcaggt gaatgcggcg ctggtcagcc atgccaagcc tgactataca 992641 tttttacatt gtctccctgc gcatcgcgag gaagaagtga ctgcggagat tattgacggg 992701 ccgaactctg cagtgttcca gcaggcggaa aaccgtcttc atgtgcaaaa agcactgctg 992761 aaggccattt tatataaagg ggaatcatca aaaaactgct gagccaaact cagcagtttt 992821 tttgatggca acatattcac agccgcttag gcgcatacta cagcaaaaag gaaaaggagg 992881 aaaaacagtg ggacagcagc accaattccg gcccggacag aaagcgccta ataacggtgt 992941 ctacgtagaa atcggcgaga cagggagcat ggttaaaaac cctcaaaagg tccatctgtc 993001 agcaggggaa atgttccccg aaacatcaaa ccacaaccgg ctgtggacct acaaaagaaa 993061 gccgtgacca ctaaaaaacc caaaacaata aatgttttgg gtttttggct ttttaatgct 993121 ggcttgcatt tttgttcata ggcatgattt ctgctaaaac catgattaag acatacagta 993181 caacagcaat gacagatgat gttttgaaat tatacgtaac gctgttcatg cttgcaacca 993241 agtagcatgc catatgtgat aaaaggaacg tccaaataaa ggcaataata tatcgcacgt 993301 ttccacctcg tccttctcat tctattctaa aagttatcat accatacaaa aagcgaaggg 993361 ggaatccaat tttagcagaa agtgaggtga caaaagagtc tgattcgtca cactttaatg 993421 gtaaaatata aaacgtcaat cagtataata gccaaaaatg taaaaggcta ggactttacc 993481 ttattcgttt cttttctatt tacataagat agcgtgagat gaagtgtgaa aggaggcggg 993541 caagcgatgg gaataacgga aagatacttt caactgggaa cggagcataa tgtcattcat 993601 ctgccctatc gcccgaacgg cttcggcatc tttatcttgg gggacagaac ccactttgtc 993661 ggacatgatt caagcttttg gcagcagcat tatggcagaa atcagcttct gagcatgttg 993721 atgaatgaag gatacactct ttttaacagc aatctgttcg gaaggcattg gggggcggaa 993781 aaagcagtca cctatgccaa acagctgata cattctgtgc tgaagcagga aatcctcaat 993841 ccgaagattc atattttagc agaaggcatg ggtgctctcg tggccgatga actgcttcgt 993901 ttttccccgg atcatatccg ctcagccgca atgttgaatc cttgtctcga tcttcaggca 993961 cattatgaat cggaaaaaga aaataaattt ttctataagc aatttttgaa agaagtatcg 994021 aaaagctacg gaatttctga aaaagaagcg gaagcgattc gttataaaac aattcaaagc 994081 tacccgagcg gcgtaccggt tcatatatgg cagcgtatga ccggagctcc atatccctac 994141 agcgtacatg cggaagtttt caaggaaaaa cagcaaaagc aaggctcacc ggtcgacatg 994201 acatttcatt tatttgagca tccaagcaga atttatgcat caatttgcaa attctttcat 994261 agtcatgaaa aagaattata gagaatataa tgacaacagc cttctctttt gcggaggctg 994321 ttttgttttg ggaaatgaaa aaccggaagg gcggcagatg caatggaatc aacgctgatt 994381 gtaggtgcgg acgaattttt cggcctttca ttatgtgagc gaatgatgga tgaaggcata 994441 catgttgacg ttgttctggc ggaaacagaa gataaaatga gacaaatgta cttagaagaa 994501 agactcatgt ggcttgggag aaatgaactc tttcgccagc ttgaacacat tggagaccaa 994561 aattatgata caatttgtat ccagttcgga agttttttgc ctttagacca atatgattct 994621 ccttatattt tagtatatga agaagaccga aaagaatggg ataaacgtga aaaaacaggc 994681 tcggaaaaaa ccgtgatcct gccgaaaatg tacgggccat ggaaagaaga aacagaggaa 994741 gacggctatt acacaaacga cgtggctgac gagttgctga gattcctgtt agaaccaagc 994801 cgtcatagca aagatcagct ttttgaattg caagtcacag agaaaacctc aaaagaagaa 994861 gcaaaaacaa aaattatcga gtggaaaaga caattttcat caattttcga caaatattaa 994921 gaaaaacctt ccatgtttcg agttttctag atacaataaa cgtataaaaa taatacatgt 994981 tatagcttgt caaaaggagt tgaacatgac ttgatcacaa ggcttgtcat gatcttttct 995041 gtcctccttt tattgagtgg atgtggacaa actccgttca aaggaaaaat tgagaaggtc 995101 ggcatgctct ttcctgatac gattaatgac ctcgtatggg gcacaaaagg gtataaagga 995161 ttactgaata tacaatccaa atacaatgtg gacgtctatt ataaagaagg cgttaaaaca 995221 gaagaagata tcataaatgc gattgaggat tttcataaga ggggcgtcaa tctgctctac 995281 ggccatggga gtgaatatgc tgaggtgttt aacttggtcg gcgaagatta tccagatatg 995341 gaattcgtca tttccaatgc gaaagcgaaa gctgataatg taacaagtgt ccattttagc 995401 ggggaagcaa tgggcttttt tggaggaatg actgctgccc atatgtcgaa aacgaatcag 995461 gtcggtgtaa ttgcttcctt tacgtggcag cctgaggttg acggttttat caaaggggcc 995521 aagtatgaaa atccggatat agaggtaaat acgaaatata cggatcattg ggatgatgat 995581 acaacagcag taaagcttta tcagaaaatg aagaacgaag gcgcggatgt tgtgtatccc 995641 gccggagacg ggtataatgt tcctgttatt cagcaaatca aaaaagacgg tctttatgcc 995701 ataggctacg tcacagatca atcggatctg ggcgagaata ccgtattaac cagcacggtg 995761 caaaatgtgg acaaggccta tgaaatcatt gctgaacaat ttaataaagg cacccttgag 995821 ggcggcgatc attactacga cctgaacacg ggagtcgttg agatgggaac attcagcccg 995881 ctcgtcgatc aagactttca gcaaagaatc gccaagctga tcaaaacata caacaaaaca 995941 ggcgagctgc caaaaaacga gtaatggagt gacgtcacat gcagcacgaa aaatcacttg 996001 aattcttgca aattgccatg aaatatctcc ctgaagcgaa agaacagctt gagaaatcag 996061 gcattgagct ctcaatggag gccatccagc cgtttatgaa tctatttaca acggtaatgg 996121 cggaagctta tgagcttggc aagtctgacg ctaaatctga aacagaataa gaagaagcca 996181 cttttttgaa agtggctttt cacatgattt tctttttaat agcggagagc atgggcgcaa 996241 gctcctttaa agcgggcttg atttgatcaa gagagttcat aattgaaccg atttggtcca 996301 taatatgcat gtaattaatc gtctcttcgt cgtttgtctg agaaacctga gaaacttcct 996361 cttgctgttc ctcctccttc tcttctgttg gttttgctgc atcgccgaac atcattcttg 996421 aaaacacatc caactgcata cgcctccttt ccatatacca tactctatga gtaagatgaa 996481 ctgatagttt agacgaatat attgccatgt gaaaaaaaat aggatagaat tagtacctga 996541 tactaataat tgatcacaac ctgattgatc ttctaaattt aagatataaa ggagtcttcc 996601 ctaatgaaag ctggaatact tggtgttgga cgttacattc ctgagaaggt tttaacaaat 996661 catgatcttg aaaaaatggt tgaaacttct gacgagtgga ttcgtacaag aacaggaata 996721 gaagaaagaa gaatcgcagc agatgatgtg ttttcatcac atatggctgt tgcagcagcg 996781 aaaaatgcgc tggaacaagc tgaagtggct gctgaggatc tggatatgat cttggttgca 996841 actgttacac ctgatcagtc attccctacg gtctcttgta tgattcaaga acaactcggc 996901 gcgaagaaag cgtgtgctat ggatatcagc gcggcttgtg cgggcttcat gtacggggtt 996961 gtaaccggta aacaatttat tgaatccgga acctacaagc atgttctagt tgttggtgta 997021 gagaagctct caagcattac cgactgggaa gaccgcaata cagccgttct gtttggagac 997081 ggagcaggcg ctgcggtagt cgggccagtc agtgatgaca gaggaatcct ttcatttgaa 997141 ctaggagccg acggcacagg cggtcagcac ttgtatctga atgaaaaacg acatacaatc 997201 atgaatggac gagaagtttt caaatttgca gtccgccaaa tgggagaatc atgcgtaaat 997261 gtcattgaaa aagccggact ttcaaaagag gatgtcgact ttttgattcc gcatcaggcg 997321 aacatccgta tcatggaagc tgctcgcgag cgtttagagc ttcctgtcga aaagatgtct 997381 aaaactgttc ataaatatgg aaatacttct gccgcatcca ttccgatctc tcttgtagaa 997441 gaattggaag ccggtaaaat caaagacggc gatgtggtcg ttatggtagg gttcggcgga 997501 ggactaacat ggggcgccat tgcaatccgc tggggccgat aaaaaaaggt gaggtgcaca 997561 caagatgact aaaaaaagag tagttgttac aggacttgga gcattatctc cacttggcaa 997621 cgacgtcgat acaagttgga ataacgcaat caacggtgtg tccggaatcg gtccgatcac 997681 tcgtgttgac gctgaagaat atccggcaaa agttgccgct gaattaaaag attttaatgt 997741 tgaagattat atggataaaa aagaagccag aaaaatggac cgctttacac aatatgcggt 997801 tgtggctgcg aaaatggcgg ttgaagatgc agatcttaac attaccgatg agatcgcgcc 997861 gagagtcggt gtttgggtag gctccggtat cggaggactt gaaacactag agtctcaatt 997921 tgaaatcttc ttaacaaaag gcccaagacg ggtaagcccg tttttcgtgc caatgatgat 997981 tcctgacatg gcgacaggcc agatttctat tgcattagga gcaaaagggg tgaactcttg 998041 tacggttaca gcatgtgcta caggaacgaa ctccatcggt gacgcgttta aggttattca 998101 gcgcggtgat gcagacgtga tggtcacagg cggaacagaa gcgccgctga caagaatgtc 998161 attcgccggc tttagtgcca acaaagcgct gtctactaat ccagatccga aaacagcgag 998221 ccgcccgttt gataaaaacc gtgatggctt tgtcatgggg gaaggtgcag ggattatcgt 998281 tcttgaagaa cttgagcatg ccctggcccg cggcgctaaa atttacggag aaattgtcgg 998341 ctacggctca accggagacg cttatcatat cacagcgccg gcccaagacg gtgaaggcgg 998401 agcgagagcg atgcaagaag ccattaaaga tgcaggcatt gcacctgaag aaattgatta 998461 catcaatgct cacgggacaa gcacgtatta caacgacaaa tacgaaacaa tggcgattaa 998521 gaccgttttt ggcgagcatg cgcataaact tgcggtaagc tctacaaaat cgatgacagg 998581 ccacctctta ggagcagccg gcggtattga agccattttc tctatcctgg ccattaaaga 998641 aggcgtgatt ccgccgacaa tcaatattca aacacctgac gaagaatgtg atttggatta 998701 tgtgcctgat gaagcccgca gacaggaact taattatgtt ctcagcaact cattaggatt 998761 cggcggacac aacgcaacat taatctttaa aaaatatcaa tcataatcaa gccaaaccgg 998821 ctgcccttaa agggtagccg gttttttttg tgtgcatagg attaaaagag gaggcgatca 998881 catgagtgta gaacaaacat atagctggct caggaaggcc ggttcaatag atgatttggc 998941 gcattacatt atcccgcttt tttcaggtgc ggagaaaaag aactggaagg gcattctggg 999001 gcatcttcag catcatggga tgtttaaaaa cataaaagag ggtattcaga cggtttccaa 999061 gctgaaggaa aaaggttttt acggacatat ccaaaaggaa gaacagtacc tcaaaaacaa 999121 atggcaaggt cctgatgtac caattgttac gctgccggtt gatgaacgaa acaggagaat 999181 ccgtttagaa ttcggatcaa aatcaggact cgcctttcaa gacaaaatgt tcctttttct 999241 ttcgtcagat ttagattttg ggtcggtatc tgcccttatg acgcatgagt atcatcacgt 999301 ttgccggtta ggtcatctga caaaagagga aaaggatgtc acattacttg atacaatcat 999361 catggaaggg ctggcggaat atgctgttta tgagaggttc ggccgaagtc aaacggctga 999421 atggacgact tggtatacac cggaacagct tcaggcttta tatgaaaaaa agattgcgcc 999481 ccatcgggat atcaaacggg ataatcgatt atttccccag ctgttattcg gcaaaggata 999541 tcagccaaaa atgcttggat acgcagttgg attcaatatt gtaaaaaaat atttaaccgc 999601 cagcaaggca agcaccgcag acgggctgtc cattcctgct gagacctttt tggatgcaat 999661 gctttaaaag gataaaataa tggaatttca ttaataatat tacatttatc ctaaaaaatt 999721 cttgattttg caaaatgatt gtaataatat acaactataa aatttttcga taattcaata 999781 ttatttatta tttctgaata aagggattgc tttctcttga aaacgtttga caacaagagg 999841 ggggaaaggg gagctagcat gagcacactt ttagaagtga ataatttaaa gacttatttt 999901 ttcaggaaaa aggagccgat ccctgcggtt gacggagtcg attttcacat cagcaaaggc 999961 gaaaccgtcg cgcttgtagg tgaatcgggc tccggaaaaa gcattacttc tttatcaatt 1000021 atgggcctcg tccaaagctc aggcggaaaa atcatggacg gctctattaa actcgaagac 1000081 aaagacctca cctcattcac tgaaaacgat tattgcaaaa tccgcggtaa cgaagtatcc 1000141 atgatctttc aggaaccaat gacctccctt aatccggtgt taacaatcgg agaacaaatt 1000201 accgaagtgc tgatttacca taaaaacatg aagaaaaaag aagcccgtca acgagctgtt 1000261 gaactcttgc agatggtcgg tttctcccgg gcggagcaaa ttatgaagga gtacccgcat 1000321 cggctgtccg gcggtatgag acagagggtg atgattgcca tcgcactgag ctgtaatcct 1000381 aaactgctca ttgctgatga accaacgaca gcgctggacg tgacaataca agcccaggtg 1000441 ctggagctca tgaaagatct ctgtcagaag ttcaatacat cgattcttct catcacacac 1000501 gacttaggtg tcgtgtctga agctgccgat agagtgattg tcatgtactg cggacaagtc 1000561 gtagaaaacg ccactgttga tgacttattt ttagaaccgc ttcatccgta tacagaaggc 1000621 ctgcttacgt caattcctgt tatagatgga gagattgata aattaaatgc gattaaaggc 1000681 agtgtgccta caccggataa tctgccgccg gggtgccgtt ttgccccaag gtgcccgaaa 1000741 gctatggata agtgctggac aaatcagcct tcgcttttga cacacaaaag cggaagaacg 1000801 gtgagatgct ttttatatga ggaagagggt gccgaacaat catgacagca gctaatcaag 1000861 aaacaatctt agagcttcgt gacgtaaaaa aatactttcc gatccggtca ggcctttttc 1000921 aaagaaaagt cggtgatgta aaagcggtgg atggtgtttc attttcgtta aaaaaaggag 1000981 aaacactcgg aatcgttgga gagtcgggct gcggaaaatc gactgccggc agaacgatga 1001041 tcagactgta caaaccgaca gagggccaaa ttctttttaa agggcaggat atttccaatc 1001101 tgtcagagga gaagctgcgg aagagtgtcc gcaaaaatat tcaaatggtt ttccaagatc 1001161 catttgcttc gttaaacccg agaaagaccc tgcgttccat cataaaggag ccgtttaata 1001221 cgcacaacat gtataccatg cgtgaacgaa acgaaaaagt tgaagagctg cttgcaagag 1001281 tagggcttca cccgtcgttt gccggccgtt atccccatga gttttcaggc ggccagcgtc 1001341 agcggatcgg cattgccaga gcactcactt tgaatccaga gctgatcatt gcagatgagc 1001401 cggtttccgc acttgatgta tccattcagg cccaagtgat taacttgatg gaggaattac 1001461 aggaagaatt taatcttacg tatctattta tctctcatga tctgagtgtc gtccgccata 1001521 tcagcgacag agtcggagta atgtatcttg gcaaaatgat ggaactgacc ggcaagcatg 1001581 agctttatga caacccgctt cacccatata cccaagcgct tttatcctcc gttccggtta 1001641 caagaaaaag aggttctgtc aaacgtgaac gcattgtcct gaagggagaa ctgcctagtc 1001701 cggccaaccc gccaaaaggc tgcgtattcc acacaagatg tcctgttgca aaaccgatat 1001761 gcaaggaaca aataccagaa tttaaagaag ctgctcccag ccactttgtg gcttgtcacc 1001821 tttatagcta atgttgcccg cacagctttg agagggggta tgcacactac ataaacaaca 1001881 gcctagaaga acgaacattt caagaggggg aatatctaat gaaaagacgg aaaaccgcac 1001941 tgatgatgct aagtgtattg atggttctgg ccatcttttt atcagcctgc tcgggatcaa 1002001 aatcaagcaa cagcagcgcg aaaaaatcag caggcaaacc gcagcaaggc ggggatttgg 1002061 ttgttggttc aatcggagaa cccacacttt ttaactctct gtattctacc gatgacgcaa 1002121 gtacggatat tgaaaatatg ctgtacagct ttttaacgaa aacggatgaa aaactaaatg 1002181 tgaaattgtc actcgctgaa agcattaaag aattagacgg cggccttgca tatgatgtga 1002241 aaattaaaaa aggcgttaag tttcatgacg gaaaagaact gactgcagac gacgtcgtat 1002301 ttacgtacag tgtcccttta agcaaagatt acaagggaga acgcggttca acatatgaaa 1002361 tgctgaaatc cgtagaaaaa aaggcgatta cgaagtcttg tttaagctga aatataaaga 1002421 cggtaatttc tacaacaatg cgttagacag cacagctatt ctgccgaaac atattctcgg 1002481 taatgttccg attgctgatt tagaagaaaa tgagtttaac agaaagaaac caatcggttc 1002541 aggaccattt aagtttaagg aatggaagca gggccaatat attaagctcg aagcgaatga 1002601 tgattacttt gaaggaagac cgtatttaga tactgtgacg tataaagtca ttcctgacgc 1002661 aaatgctgcc gttgctcagc tgcaggcagg cgatattaat ttctttaatg tgcccgccac 1002721 tgactacaaa acggctgaaa aattcaacaa cctaaaaatc gttactgatt tggcattaag 1002781 ttatgtgtac atcgggtgga atgaaaaaaa tgaattattc aaggataaaa aggttcgtca 1002841 agcgctaaca accgctcttg accgcgagtc aatcgtcagc caagtattag atggagacgg 1002901 cgaggtagct tacattccgg aaagcccttt atcttggaac tatcctaaag atatagatgt 1002961 tccgaaattt gagtacaacg agaaaaaagc gaaacagatg cttgcagaag ccggctggaa 1003021 agatacgaac ggtgacggca ttctggataa agacggaaag aaattctcgt ttacccttaa 1003081 aacgaaccaa ggaaacaaag tccgtgaaga catcgctgtc gtcgttcagg aacagctgaa 1003141 aaaaatcggc attgaagtga aaacccagat cgttgaatgg agcgctctcg ttgaacaaat 1003201 gaatcctccg aattgggatt ttgatgcaat ggtcatggga tggagtttat ccacattccc 1003261 ggatcaatat gatattttcc attcaagcca gattaaaaag ggtttgaact acgtttggta 1003321 taaaaatgcc gaagcggata aactcatgaa agatgcaaaa tcaatcagtg acagaaagca 1003381 gtattcaaaa gaatatgagc aaatctatca aaaaattgcg gaagatcagc cgtatacgtt 1003441 cttgtattat cctaacaacc atatggcaat gccggaaaat cttgaaggat acaaatatca 1003501 tccgaaacgt gatttgtata atattgaaaa atggtggctt gcaaaataaa tttcccttaa 1003561 aggggaggga gagcgttttc tccctcttct gtttttaata aggaaagtaa agggggacaa 1003621 gtatatggct gcatatatta tcagaagaac cttaatgtct atcccgattt tattgggaat 1003681 tacgatttta tcatttgtta tcatgaaagc cgcgcccgga gatccgatga cattaatgat 1003741 ggacccgaaa atcagccagg ctgacagaga gcagtttatt gaaaaatacg gtctgaatga 1003801 tcctcagtac gttcaatatt taaagtggct aggcaacatg gtgcagggtg atttcggaac 1003861 gtctattgtc agaaaaggaa cgcctgtttc agaattgatt atggcaagac tacccaatac 1003921 gctcctgctg atgctggttt caacgatttt ggctcttatg atttctattc cgttcggtgt 1003981 cctgtcggca aagcggccgt attcaaaaat cgactatggc attacattta cctcgtttat 1004041 aggcctggct attccaaact tttggtttgg attaattttg attatggtgt tatcggtaaa 1004101 tctcggctgg tttccaactg ggggtgtcga gacactgaat accgaattca atatatttga 1004161 ccggattcat catttaattc tgcctgcatt cgttctagct acagctgaca tggccggact 1004221 gacgagatac acgagatcca atatgcttga tgtattaaat caagattata ttcgcacagc 1004281 gagagcaaaa ggatttaaag agaacagagt gctatttaaa catggattga ggaatgcatt 1004341 attacccgtc attacaattt tcggtttgat gattccttca tttatcggcg gatctgtcgt 1004401 tgtcgaacaa attttcactt ggccgggatt aggaaagctg tttgtcgatt cagcattcca 1004461 gcgcgattat ccggttatca tggcaatgac tgtgatctcg gcggttcttg tcgttgtcgg 1004521 aaacctcatt gcagacatcc tttacgcgat tgttgatccg cggatcgaat attaaaagga 1004581 gggaaacaga gatgtcagag ctgcaaacaa ctccctcgcc ggagatcagg ctgaaagaaa 1004641 atatttcgaa aaagccagaa acaatgacaa agattttctg ggaaaaattc tcgaaaaaca 1004701 aactggccat tttaggtgcc gttattcttt ttatcattat tatgtctgct gttttcgccc 1004761 ctttaattgc accttatccc caagagcagc aaagcctgct tgataaatat aaggcgccgg 1004821 gccttgaaca tctgatggga acggataaat ttggacgtga tattttcagc cggatcctat 1004881 atggagcgcg tgtctcttta ttggttggat ttgcgtccgt agtcggttcg attttgatcg 1004941 gaacggtttt aggagcatta gccggatatt tcagaggaat agtggatgct gtcattatgc 1005001 gtgtagttga cattgtgtta tccattcctg atattttctt gttgatcacg ctggtcacca 1005061 tcttcaagcc gggtgtggac aaattgattt taattttctg tctcacagga tggaccacaa 1005121 cagcacgatt agtaagggga gaattcttgt cgctccgttc aagggaatat gttcttgctg 1005181 ctaaaacaat tggaacaaaa acgcacaaaa ttattttttc tcatatcctg cccaatgcgt 1005241 tagggccgat tatcgtgtca gctacgctga aagttgggtc tgttattcta gctgaatcgg 1005301 cgctaagcta cttgggcttt ggaatccagc cgccaatcgc tagctggggg aacatgcttc 1005361 aagacgcaca gaatttcaca gtaatgattc aagcatggtg gtacccgtta tttcccgggc 1005421 tatttatttt aatgaccgtt ttatgcttca actttgtcgg tgatggcctg cgggatgcgc 1005481 ttgacccgaa aaatattaaa taaaaatgaa tatcatatct gttataaaat atcaccaaat 1005541 cagaaaaaag caggtctcct ttagtcagaa aatatacaaa gagatctgct ttttatgatt 1005601 cttacataaa cccagtgatt ccagatttcc tcaatctctt tggaataatt tctctatccc 1005661 ttgcctatac tgtggacaac agtttttata aaagtgaggg gttagagatg ttatttcttc 1005721 atgatgtgtg ggtcaattgg tttgaagggg aagaaaatgg ctacaatgta tgccactttc 1005781 acgaatggcg caaggaagat acggttgagc ttttggatca ggtgccgctg ttaagggtgc 1005841 cgtcagtact gtttcattac atagaaaacg atttgtcaga gcttccgaaa ggtttgcttg 1005901 aagacgtaca tcagaaatcg tacattcgaa aaaatcatga gcggacaaag cttgagtatt 1005961 gttttgtcgt aacagacgga atcggcattt tagctgttga cacgatcggc tacacgatcc 1006021 ctgtcagaaa aagccgtcta atcccaagac aggagcagct cgtttatgaa atggtaaaag 1006081 atgtagagcc tgaaacatat gaatttgagc caaagaagct ggaatcctcc aaggaatatc 1006141 acatcttatc attagcacca gaacatgtca gaggactgac aagaaaagaa cggcaaatta 1006201 agcagctgat gtttatggcg cttgaccaat taaaagggct gaaaaaccga gcggaaattg 1006261 gctactggta cacagagtgg aatccgcata tgtatgaaca aatcaaaagg atgagctttg 1006321 aagagatttg ggacatgctg tataacgaaa caattgaagg ctggtcggac aaacacctag 1006381 ctttttgcga aaacctaata aaaggacagc cttttttcga aaagctttgg gaaatggaaa 1006441 acgaatcaaa ggtcaactga aaaaaaccgc tctttgcaaa gagcggtttt ttgattagcg 1006501 tctttttctt ccaagaccca tggcattctc catttttttc agcattttgt ttgctgtccg 1006561 attcgctcgt tccgcgcctt catcaagaat ccggtctaat tcttcagatt ctatcagctc 1006621 gtaatagcgg tcctggatcg gttttaatgc gttcactacg acttctgcca aatcaccttt 1006681 aaactcgccg tagccttttc cttcgtactt tgcttcaagc tcttcaattg tcgtattgcc 1006741 gaggattgaa taaattgtaa gaaggttgga aacgcccggt ttgttttcct tatcaaattt 1006801 gacaatgcct tcagaatccg ttactgcgct tttgattttc ttttcaagct gcttcggctc 1006861 atccagcaat gtaatataag ctttctgatt cggatcagat ttgctcattt tcttcagcgg 1006921 atcattcaga gacatgatac gtgcaccgac ttttggaatt ttcacttccg gaatcgtaaa 1006981 gatgtcgttg tattttttgt tgaagcgttc tgcaagattc cgcgtcagct caaggtgctg 1007041 cttttgatcc tcgccgacag gtacaagatc cgttccgtac agcagaatat cagcggccat 1007101 cagcggcgga tatgttaaca ggccggagac gacagcttca ttgcctttgg atttgtcctt 1007161 aaattgagtc atccgctcaa gctcgccgat ataggcgaca cactgcatca tccatccggc 1007221 ctgcgcatgt gcggggacct ctgactgaat aaacaatgtt gctttttctg gatcaagtcc 1007281 gacagctaag taaagcgccg cgagattgcg gatattcttt ctaagctcaa gccggtcttg 1007341 aggaacagtt atcgcatgct gatcgacgat gcaaaaatag ctgttataat catgctgcag 1007401 ttcgacaaac tgcttcattg caccgatata gttgccgagc gtcactgagc cgcttggctg 1007461 aatgcctgaa aaaatcgttt gtttcatgaa aacatcaacc tcatttctta aaacataata 1007521 aaaaaggctc attcttcccc tgtaaaaaag ggacgaatga accgtggtac caccctgatt 1007581 attccattaa aatggaatca ctctgacgtt tgtaacggag actgctccgg ctgagcctac 1007641 ttttttccag ttcggtcagc tgctccaaag tccattccac attgcccgtt atctgctccc 1007701 agcaccgcag actctcttca aacaggtgaa acgtgtacta ctctttttca tagcaagctt 1007761 ttcttttgat tgcttcatta taaatcaatt ataaccaatt gtcatcatga aaaaacattc 1007821 ttttttccag taaaattgta ataatataaa taacacgagt gctgtaaaat ccttaaatga 1007881 taactgctat cagcgtaaaa acaggcagat attatatgta aaaagcaata tgggcagaaa 1007941 acacatgaaa aagtttttaa tcaatttatg ctttaaatgg tagaaggata ttatgttcat 1008001 ggaagaaaaa ctaacgaagt ttaaatattt taaattgata aaataatatt gcaataaatt 1008061 atttgtttca ttataatgaa cttgttcact ctattgttac agctttttta caaaaataat 1008121 cagaaaagac ggaacagaat aaaagttgtg gaaactcagg ttcatttgtc tgatatttct 1008181 gaggatttag ccgtaaggag ctgaaaatta ttattagggg gtttgcgaat atgaaaaaac 1008241 gttggtcgat tgtcacgttg atgctcattt tcactctcgt gctgagcgcg tgcggctttg 1008301 gcggcagcgg atcaaacggt gaagggaaaa aggacagtaa aggaaagacg acacttaaca 1008361 ttaatattaa aactgagccg ttctccttac atccgggatt ggcaaatgat tcagtatcag 1008421 gcggtgttat ccgtcagact tttgaaggat tgacacgtat caatgcagat ggtgagcctg 1008481 aagaaggcat ggcttctaaa attgaaacga gcaaggacgg aaagacatat acatttacca 1008541 ttcgtgatgg tgtgaaatgg tctaatggag accctgtaac tgcacaagat tttgaatatg 1008601 cttggaaatg ggcgcttgac cctaataatg aatcacaata cgcttaccag ctctactaca 1008661 taaaaggtgc tgaagcggcg aataccggaa aaggcagcct agacgatgtg gcagtaaaag 1008721 ctgtgaatga caaaacgctg aaggttgaat taaataaccc gactccatat ttcactgaat 1008781 taactgcgtt ctatacgtat atgccgatca ataagaaaat tgcagagaaa aataaaaagt 1008841 ggaatacaaa tgccggagat gattatgtat caaacgggcc gttcaaaatg acggcatgga 1008901 aacacagcgg ctctattact ctcgaaaaaa atgaccagta ttgggataaa gacaaagtca 1008961 aactgaagaa aatcgatatg gttatgatca acaataacaa tacggaacta aaaaaattcc 1009021 aagctggcga acttgattgg gccggtatgc cgctcggaca gcttccgaca gaatccctgc 1009081 cgaccctgaa aaaagacggt tctttacatg ttgagccgat tgcaggagtg tattggtaca 1009141 aattcaacac tgaagctaag ccattagaca acgtcaatat ccgtaaagct ttaacatatt 1009201 cgcttgaccg tcagtcgatt gttaaaaacg ttacgcaagg agagcaaatc ccggcaatgg 1009261 ctgcagtgcc gcctacaatg aagggatttg aggataacaa agaaggatac ttcaaagaca 1009321 atgatgtcaa aacagcaaaa gaataccttg aaaaaggcct aaaagaaatg ggcttaagca 1009381 aggcatctga tttgccaaaa atcaaattgt cttacaacac tgatgacgca cacgcgaaaa 1009441 tcgctcaagc agtacaagaa atgtggaaga aaaatttagg cgttgatgtt gagcttgata 1009501 actcagagtg gaatgtctat attgataagc tccacagcca agattatcaa atcggccgta 1009561 tgggctggct cggcgacttc aatgatccta tcaacttcct tgaattgttc cgcgacaaaa 1009621 acggaggaaa taacgataca ggctgggaaa atccagaatt caaaaagctt ctgaatcagt 1009681 cacaaactga aacagataaa acaaaacgtg cagagctgct gaaaaaagca gaaggtattt 1009741 tcattgatga aatgccggtt gccccaatct atttctatac tgatacttgg gtacaggatg 1009801 aaaacctaaa aggtgttatc atgccaggta ctggtgaggt ttatttcaga aacgcatatt 1009861 ttaaataagg ctacgtctga aaataaaaga cctcaaggta tatggggaga aaagccccat 1009921 atacctttct tactgatgga gtataaaaat gtaaaaacca tggaggtgtt cccccttgct 1009981 aaaatatatc ggaagacgct tagtctatat gattatcaca ctatttgtga ttgtaactgt 1010041 gacattcttc ttaatgcaag cagcaccggg cgggccattt tcaggtgaga aaaagcttcc 1010101 gcctgaaatt gaagcaaatt taaatgcgca ttatggcttg gacaagccgc tgtttgtaca 1010161 atatgtcagt tatttgaaat cagttgcaat gtgggatttc ggaccgtcat ttaaatataa 1010221 aggtcagagt gttaacgacc tgatcagttc aggtttcccc gtttcattta ctcttggagc 1010281 agaagctatt ctcctcgctt tagcgttagg tgtattgttt ggggtcattg cagcccttta 1010341 ccataataag tggcaggatt ataccgtcgc gattttaacg atatttggta tttcggttcc 1010401 gagctttatc atggcggctg ttctgcaata tgtgttctcc atgaagcttg ggctgtttcc 1010461 ggtcgcgggg tgggattcct gggcatacac ctttttgcct tccatcgcac ttgcttccat 1010521 gccgatggcg tttattgcca gactttcccg ttcaagcatg atcgaagtgt taaacagtga 1010581 ttatatccgc acagcgaaag cgaaagggct ttcccgccca gcggttacag tgcggcacgc 1010641 cattcgaaac gcacttttgc cggttgttac atatatgggc ccgatggccg cacaggtctt 1010701 aacggggagc ttcattattg aaaccatttt tgggattccg gggcttggtg cacacttcgt 1010761 caacagtatt acaaaccgtg attatacggt cattatgggt gtaacggtgt tcttcagtgt 1010821 catcttgcta ttgtgtgtat taatcgtaga tgtgttatac ggcattattg atccaagaat 1010881 caagctttcc aaagcaaaga aaggagccta ggccatgcag aacattccaa aaaacatgtt 1010941 tgaaccagcc gcagcgaatg ccggcgatgc agaaaaaata agtaaaaaga gcctttccct 1011001 ctggaaagat gcgatgcttc gcttccgcag caataagctt gcaatggtcg ggcttatcat 1011061 tatcgtactt attatcctta tggcaatttt tgcgccgatg ttctcaaggt atgattattc 1011121 aactactaat ctcttaaatg cggataagcc gccttcaaaa gatcactggt tcggaacaga 1011181 tgatcttgga cgggacattt tcgtccgtac atgggtaggg gcgcgaatct caatctttat 1011241 cggtgttgca gctgctgttc tcgatttgct gatcggcgtc atttggggga gcatttcagg 1011301 cttccgcgga ggaagaacag atgaaatcat gatgcgtatc gctgatatcc tttgggcagt 1011361 tccttcatta ttaatggtta tcttactgat ggttgttctt ccgaaaggtc tatttacgat 1011421 tattattgcc atgacgatta caggctggat taatatggcc agaatcgtgc gcggacaagt 1011481 gctgcagctg aagaatcagg agtatgtgct tgcttcacag acactgggtg caaaaacatc 1011541 ccgtcttcta tttaaacata tcgtgccaaa cgcaatgggt tctattttgg tcacgatgac 1011601 actgacagtt cctactgcga tttttacaga agccttttta agctatttgg gacttggtgt 1011661 tccggctccg ctggcaagct ggggaacgat ggcttctgac ggattgcctg cattgaccta 1011721 ttatccgtgg cgtttattct tccctgccgg atttatctgc attacaatgt ttggttttaa 1011781 cgttgtcggc gacggattaa gagacgcatt ggatcctaag ttacgtaaat aagggagtga 1011841 tacgggtgac acgcctatta gaagtaaaag atttagcaat ttcatttaaa acatatggcg 1011901 gagaggtcca ggcgatccgc ggagtgaatt tccatctgga taaaggggag acgctggcca 1011961 ttgttggaga atcaggttcc ggaaaaagtg taacctctca agcgattatg aagctgattc 1012021 caatgcctcc gggttatttc aaacgcggtg agatcctgtt tgaaggaaag gatctggtgc 1012081 cgctgtccga aaaagaaatg caaaatgtcc ggggaaaaga gatcggcatg atattccaag 1012141 atccgatgac ctctttaaat ccaacgatga aggtcggtaa acaaattacg gaagtgcttt 1012201 ttaaacacga aaagatctcg aaggaagcgg ctaaaaaacg cgcggttgaa ctgctggaat 1012261 tagtcggtat cccaatgccg gaaaagcggg tgaaccaatt tccgcatgaa ttttcaggcg 1012321 ggatgagaca gagggttgtc attgccatgg cgcttgcagc gaatccgaaa cttctgatcg 1012381 ccgatgagcc gacaactgct cttgatgtaa cgattcaagc gcaaattttg gaattaatga 1012441 aggatttgca aaagaaaatt gacacgtcca tcatctttat cacacacgat cttggtgttg 1012501 tggctaacgt tgctgaccgg gtcgctgtca tgtacgcggg acagattgta gaaactggta 1012561 cggtagacga aatcttctac gacccgagac atccgtacac ttgggggctt cttgcatcca 1012621 tgccgacact ggaaagttca ggagaggaag agctgactgc aattccgggc acgccgcctg 1012681 atttgacaaa cccgccaaaa ggagatgctt ttgccctgcg gagctcttac gcgatgaaaa 1012741 tcgattttga acaggagccg ccaatgttta aggtatccga tactcattat gtaaaatcgt 1012801 ggctgcttca tcctgacgcg ccaaaggtag agccgcctga agcggtaaaa gcgaaaatgc 1012861 gtaaactggc aaacacgttt gaaaaacctg tcttagtgag agaagttgaa tgaattgact 1012921 gaaaaactat tagaaatcaa acatttaaaa cagcactttg tcacgccgag gggaacggtt 1012981 aaggctgtag atgatttatc atttgatatc tataaaggtg aaacattagg gctggttggt 1013041 gaatctggct gcggtaaatc gacaacaggc cgaagcatta tcaggctgta cgaagcaacc 1013101 gatggtgagg tgctgttcaa cggcgaaaat gtgcacggga gaaaatcgcg gaaaaagctg 1013161 ctggaattca accgcaaaat gcagatgatt ttccaagacc cctatgcatc cctgaatccg 1013221 agaatgacag ttgctgatat tattgctgaa ggccttgata ttcataagct ggcaaaaacg 1013281 aaaaaagagc ggatgcagcg agttcatgaa ctattggaaa cagtgggatt gaacaaggaa 1013341 cacgcgaacc gctatcctca tgaattttcc ggcggccagc gccaaagaat cgggattgcc 1013401 agagcgcttg ctgttgatcc ggaattcatt atcgcggatg agccgatttc cgctttggat 1013461 gtatccattc aagcgcaggt cgtgaattta atgaaagaac tgcaaaaaga aaaagggctc 1013521 acatacctgt ttattgccca cgatttatcg atggtcaaat acatcagtga ccgcattggc 1013581 gtcatgtatt tcgggaaact ggttgagctt gcgccggcag atgagcttta tgaaaatccg 1013641 cttcacccat atacaaaatc attgctttct gcgattccgc ttcctgatcc ggactatgag 1013701 agaaatcgcg ttcgccagaa atatgatccg tctgtccatc aattaaagga tggggaaacg 1013761 atggaattcc gtgaagtcaa accgggacat tttgtgatgt gcacggaagc cgaatttaaa 1013821 gctttttcat gattcatcaa tccttcaaga gatttctctt gaaggatttt tttgcgtctt 1013881 catagaaagt gagaatgata acatttacaa ttagaggaaa aagcggaggc gaaatacgat 1013941 tcaatttctg cataacaaaa atgtttttgc gctattgctg tctcaatctt ttcaatcttt 1014001 agcaggagtc ctcgtcacaa tcgttttaat ggtccggatc tatcaaatga ctgactccgt 1014061 ttttttggcg ggccttattt tatcgttcat gtcgtttgcg agtatagcag caagcttttg 1014121 cgtctctccg gtgcttcgca ttctcggttt taaaaaggtg cttgcgggag cgaatctgct 1014181 gagagcggtc tttattatac tgatggcata cagcgtcact catcacggac aggcattctt 1014241 ttggattacg ctgctgtttg tgttttgttt ttccttcgcg ggcgcttttt ttcagccggc 1014301 aagatttgcg ctgctgccga ttattgttcc aaagaagcaa tatgtaaaag cgaatggtgt 1014361 gatctccctc tcgaatcaat tgttcttaac agcaggctgg ggccttggag gccttctgac 1014421 gtacgccgtc ccttttgaac tcgttgtcgg cgctgccatt tgcctgtttg ttctatcggg 1014481 agcttccatc agtgtgctgc atgtaaatga agaagaggct gcaggaactg ctgaaacagc 1014541 atctgtcaga agtatatgga aggatttaat gatcatccct attgtaagag acattactgt 1014601 aatggacatg ttagaagctt tggcgggttc cgtatggtca tctgctattc tcctcgcatt 1014661 tactgcggct gttttgcatg aaacagaggt gtggtggggg atgtttaacg cttcctattt 1014721 tataggcgca attgtcggca gtgtgattgc tattcgtttt tcttcttttt ttgagcggaa 1014781 tatgggctat gccattatgt tcagctcgct tgtaatgtcg gcgctgaccc ttttgttttc 1014841 attttctcca gtcccatttt tatgcgctct ggcttgtgct gcaatggggc ctttttatca 1014901 ggtgcgtgat atttgccagg aaaccatgct gcaggaagtt attcccgagc agaaacgaat 1014961 cggaatcatg gctgcaaaaa atgcgatttt gactccttgg tcaggcgtca cctactccat 1015021 tatggggcta gtggctgatg ctgctggtgc gaaaatagct tttatcgcgg ctgctgcatt 1015081 atatatcatg acatttctga ttgcactggc gcagccccgt ctggttcatt acaggcgaga 1015141 aaatcgagtt caatgagaaa cacttcaaaa tgaacggagc agctggctcc gttttgctga 1015201 aaaaaaaatg aaaccatggc ggaagttcgc acgtctttat agatgtaagg ctgtttaaac 1015261 aagaagaaat ggggtatatc taaaagtatg aagacaacga actcataagg agcaaatcaa 1015321 tgaactggta tgaaaagctt agcgagtact ttccaattga agaaatgaaa tcaaaagcgc 1015381 atatggaagc tcttctgaaa gagcgaagcg atatttatca taaagatgaa ggcaaacatc 1015441 atattttaat gtttgcggaa ttcgattctt ttatcttcgt tgattatctg tatgtgtcta 1015501 aggatgcaag agggcagggg cttggcggca aattgatcgc gaagctgaaa aagaaaaata 1015561 agcccatatt gctcgaggtg gaacctgtgg atgaagatga tactgataca gaaaaacgcc 1015621 tgaggtttta tcaaagagag catttcaagc atgctcagtc aattgggtac cggcgccggt 1015681 cattggctac gaatgaagta aacaagatgg agattctgta ctggtcacca aaaacagaat 1015741 cagaagaaga aattcttgaa gccatgaaac agacatatga aaacattcat acttataaag 1015801 atgagaaatg gtacggagaa tcgtacgaaa aaacggatga ggtcttggaa atcatcgatg 1015861 aagaaaaaca aaaaaatatt ttcgatcagt taagctaatt gagaataaga acatatcatg 1015921 aacattaaaa atttgctgga ttgacacatt tttttcttag gatactgttc acacttactt 1015981 ttttatagta taatacctgt aaagattcct tttttagagt aatttcaatt taagaataaa 1016041 atagatgttc atcctactaa ttagaggagt gaagatgaat ggttacacta tacacatcac 1016101 caagctgtac ttcatgcaga aaggcgagag cgtggctcga ggagcacgag attccatttg 1016161 tagaaagaaa cattttctct gaacctttat caattgatga aataaaacaa attcttcgaa 1016221 tgactgagga cggaacagat gaaatcatct caacccgttc aaaagtattc caaaaactga 1016281 atgtgaacgt tgaatctatg ccgctgcaag atttgtaccg cttgatcaac gagcatccag 1016341 gtttgcttcg ccgtccgatc atcattgacg aaaaacgttt gcaggtcgga tataacgaag 1016401 acgaaatcag acgtttcctg ccaagaaaag ttcgctcttt ccaattaaga gaagcacagc 1016461 gtttggcaaa ctaatagatc gtatcatcaa aagaaggctg agtcatcagc cttcttttat 1016521 ttttcaacct gctggtaata aatgctcgca aggatgacaa acgcaaccgt caaaatgggg 1016581 aggagcgttt cgactgtgcc gtgctgcgcc ataaaaagcg acagcttttt gtctctgaca 1016641 atcatttctc cgccagtata agcaagcagc ccgcttcccg cgtaaatcag aagcggtatt 1016701 ttctctagtg caatatggat gagtttgctg ccccaaataa taaccggaac cgatacacac 1016761 aatcctataa caacgagaga aaactcaccg tgtgaagctc ccgcaactgc gatgacgttg 1016821 tccagcgaca taaagagatc tgcaagcaca atcgttcgta tcgctctcca cagggaggtg 1016881 ctgcttttaa tgtgtttcgt gtcttttttt tcaatcagca gctgatatcc taaatacagc 1016941 aggaaaattc cgccggcgca ctgcaagaac ggaatgttca aaagatatac tgctgcactt 1017001 gttaatccga ttctcatggc aacggcaata aatgttccga gaataatggc ttgctgtctt 1017061 tgcttgtccg gcaaatgtct gctggccatg gcaataacaa ccgcgttatc tccgccgagg 1017121 atcaggtcaa tcccaacaat gacgagcaga gaaatcagat agtcatgctc catgaagcgg 1017181 cacctcgctt tcagtccttc gcttgtacta ctactatatg agacaggtca tattttatga 1017241 tatcagccgc ctgatctgcc gttttttagg caaaggtgca tttttatttc ttttgtgact 1017301 gttttatcat aaaatagaaa tacaaaggaa ttcacactgg ccttggttaa ggttaagatg 1017361 tggacggaat gggtaaagtg tagtaaagta caattaatcg ggagcttaga tgtcccttca 1017421 acatcttata tagaagggaa ggttggcaaa tggaaattga aagaattaac gagcatacag 1017481 taaaatttta tatgtcttac ggagatattg aagatcgcgg ttttgacaga gaagaaattt 1017541 ggtataaccg tgagcgcagt gaagaacttt tctgggaagt catggatgaa gttcatgaag 1017601 aagaggaatt cgctgtggaa ggcccacttt ggattcaagt tcaggcactg gacaaaggat 1017661 tagaaatcat cgtcacaaaa gcccagcttt ccaaagacgg acaaaagctc gaactgccga 1017721 ttcctgagga taaaaagcaa gaaccagcat ctgaggatct tgacgccttg ctggatgatt 1017781 tccagaaaga agagcaagcc gtcaatcagg aagagaagga gcaaaagctt caatttgtct 1017841 tgcgatttgg cgattttgag gatgttattt ctctatctaa attgaacgtt aacggaagca 1017901 aaacgacttt atattcgttt gagaaccgat attatttata tgtagatttt tgcaatatga 1017961 ctgatgaaga ggttgaaaat cagctaagca tcctgctgga gtacgcaact gaatcctcaa 1018021 tcagcataca ccgtcttgaa gagtacggca agctgattat ttcagagcat gctctagaaa 1018081 cgataaaaaa acactttgca tcatagcaaa ccgatttcct tccggaaatc ggtttttttt 1018141 atgcacgaaa atgccatttt agagatgtga aaaatcaaaa acatatagac aagcagaaaa 1018201 tacagcgaac aggagttgat catcttttcc agaaagtata cttcatctgg aaaggagaga 1018261 tgacaattgt ttagtgctgt gactgaagac ggccaaatgt ttcaccttct aggcgctcag 1018321 caaaaccaga aattaaagcg gagacggttc ttctgtccgg tatgcggggg agagctagct 1018381 gtgaagctcg gacttcaaaa agcgccgcat tttgcccata aacagaacaa gtcctgcgcc 1018441 atagacatcg agccggaaag cgcctaccac ttagaaggaa aaagacagct gtatgtatgg 1018501 ctgaaaacgc aacgggcttc accaatattg gagccgtata taaggacaat caaccaaaga 1018561 ccggacgtca tggcaagaat caaggagcat atgcttgctg ttgaatatca atgcgccact 1018621 atcgctccag atgtctttca aaagcggaca gagggcttca aacaagaagg aatcatcccg 1018681 cagtggatta tgggatacag ccgcttaaaa cggactgctt cgtcctttta tcagctttca 1018741 acttttcatt ggcagtttat caatgcaagt ccatacagag aactgatatg ttattgtcct 1018801 gaaaggcgtt cttttctccg gctcagccac atcattccat tctacacaaa ccattcttat 1018861 tcctcagtcc aaacgatccc tatccatcgg gcaggtgcag gcgatctttt tttcactgaa 1018921 ccgaaaccct caattcaata ttcaggctgg acgaaagcga ttcaccgttt tcgccataaa 1018981 ccccatcggt ttaactcaaa ggaaacaaat cgccttaggc tgctgtttta tgagaaacga 1019041 cagacgcctt tttcttttct gccgactgaa gtgtttgttc ctgttagaaa aggggcagtt 1019101 tttaagagtc cggtttttgt gtggcagggg tttctttatt tgtttatgac ggatcttgga 1019161 ggtaaacgtg cgccaattcg tttttcagcc gttttgcagc agtgcaaact gcacattcat 1019221 aataagaaca ttgcactcag gtccgaatgc agcgaagagt gtctttcaga agcggttaaa 1019281 cagtatattg attttttgtg caagaaggga tttttaaggg agactcagaa agaagtatat 1019341 gtgctgaatc agcctgcagg aggcatacac tccatgcagg atctcataga aagagaccgc 1019401 agctgtttta tagaatgagt ttgtcttatt tggctcaccc taagacaaag gtggtgggca 1019461 ggctgtgaaa ggcacaaaag gaaaggtttt tcgtgttttt actgcttttt tggcattcgt 1019521 tctcttcatt actgcatatg atttgacaaa aggcagtgaa aaaccggaag atattcacaa 1019581 cacaagttta ttgagaaaca gctgtttttt caattggctt gaatcaaaga agacgagggg 1019641 gatcaccatg gctgaggaaa aaaaagcaaa ccaactgcct gacagaagtg aggtaaaggc 1019701 agaagacaca tggagacttg aggatatttt tcctagtgat gaggcctgga ataaagaatt 1019761 tcaagctgta aaagaattaa ttccgaattt atctaagtat aaaggaaagc tggcagattc 1019821 agctgatcat ttatacgagg ctcttacgta tcaagataaa gtgatggagc ggctaggtag 1019881 gctgtacaca tatgcgcata tgcgctctga ccaggatact gggaactcct tttaccaggg 1019941 gctgaatgac aaggcgggaa acctgtatac acaggccgca agcgcgacag cttatttggt 1020001 tccggagatt ttatccatag aagaagacaa actgcagcag ttcattcttg aaaaagaaga 1020061 attgaagctg tactctcatg cgattgagga gattacaaag gaacgtccgc atgtgctgag 1020121 cgagaaggaa gaggcgctgc ttgctgaagc ctccgaggta ctggggtcat cttcaaatac 1020181 attcagcgtg ttaaataacg cagatataac gtttccatcc attaaagacg aagatgggaa 1020241 tgaaaaacag atcactcacg gcaactttat taatttcttg gaaagtgaaa accgtgaagt 1020301 ccgcaaaaat gcgtttgacg cagtgtataa aacgtacgga caatataaaa acacaatggc 1020361 cacgacgcta agcggcactg tgaaaaagga caacttctac gcgagagtga aaaagtacaa 1020421 gtccgcgcgt gaggctgcgc tttctaacaa cagtattcct gaggaagtat acgataacct 1020481 tgttaagacg attaataagc atttgccgct cctgcaccgc tatattgcgc taagaaagaa 1020541 agtgcttgag cttgatgaag tgcatatcta tgacctgtat acaccgcttg tgaaagatgc 1020601 tgggatgaag gtgacatacg aggaagccaa agattacatg ctgaaaggcc tcgcaccttt 1020661 aggggaagaa tatgcctcta tcctaaaaga aggactggaa aaccgctggg tggacgttta 1020721 cgaaaataaa ggcaaacgca atggggctta ttcatcagga gcttacggca cgaatccgta 1020781 tattttgatg aactggcata ataacgtcaa taatctcttt acgctcgtgc acgagtttgg 1020841 acattccgta cacagctact atacgagaaa gcaccagcct tatccatacg gcaattacag 1020901 catctttgtc gcggaagttg cctctacgac aaatgaagcg ctccttggcg aatatttgct 1020961 gaacaattta gaggatgaaa aacagcgctt atatattctc aaccatatgc ttgagggctt 1021021 caggggaacg gtcttcagac aaacgatgtt cgctgaattt gaacatctga ttcatacaaa 1021081 ggcgcaagaa ggcgagccgc ttacacctga gcttctgaca aatgtctatt acgacctgaa 1021141 taaaaagtat tttggagacg gcatggtgat tgataaggaa atcggccttg aatggtcgcg 1021201 tattccgcac ttctattaca attactatgt gtatcagtat gcgacaggtt acagcgctgc 1021261 ccaagcatta agcagccaga ttttgaagga aggaaagccg gcggttgacc gttatattga 1021321 cttcctgaaa gcgggaagct cacaataccc gattgatgtc ctgaaaaaag cgggtgttga 1021381 tatgacgtct ccagagccaa tcgaagccgc gtgcaaaatg tttgaagaaa aacttgatga 1021441 aatggaagag ctgctgatga aagtcaagca gtcttaaaaa agtaagcctg tgcggaaatg 1021501 acgcacaggc ttttttaaaa ccctttaaag gttttccggt gattcaagcg gtagagggta 1021561 aacaaaatag acagaaacag cagaggagag gtaatataaa gcggcagcat atgcatcatg 1021621 cctaagatat tcaagcagaa aaaaacagca atgcacacaa ttgagatcaa agtagacatc 1021681 atggcggtcc tcctcgtcct ttttccttat aaggatatga gtgaatgcac ttcgttatgt 1021741 tttgtgacaa aaatatgaac attaagcata gaggttgtca aaagtcgaca tcttttgtta 1021801 tcataaggat gtgaaattga tcacaaacaa acattacccc tttgtttgac cgtgaaaaat 1021861 ttctcccatc ccctttgttg tcgttaagac atatgaaacc gcgcttatcc cggcgcggtt 1021921 tctttagtgc taaaaatgga acgtacgttt ggttatggca taaaaaaaca gcctcaagca 1021981 tatgcacgcc tgcggctatt tttcacatga ttgatattca tcagaataag tgctgagaga 1022041 cttccaaaac attccgtgtt tggcttccac tttggcaacc tttttagcaa acgccagttt 1022101 tttcatttct ttttctacct cttcaaggct caggtcatat acaagagcaa tttccttcga 1022161 ggcaacgaag cggaaatatt caataaaaca ttctaaaggc ggtgtttccg acggcttcgg 1022221 ctcgtcgcca agcatctcaa ataaaatttc ttcatataca tcatatgagt agctgccagg 1022281 aactttaagc ccttcatcct catgctgcgt attaaaaaac gtcagtgtcg gattaacaga 1022341 aacatccatc tcggcagcaa ttttcatgtc acattgaagc gccttgaccg cgctttgaga 1022401 atgcagatct tttttgaatt cttcaagatc gagacttgta ttttcagcaa tctccaaaag 1022461 cacgttttca tccgtaatat ttttctttga aacaaatagg ctctcctgca tatttctgag 1022521 aaattgcatg ccggcttttc gtccttgcag ttcggctgct ttaaaagcga gagcagccat 1022581 ataaggcgat gaaagcggct gatcctgttc gaaccagaca ttgccgtcac atgacatgcc 1022641 agagcggctc gcgatctttt cccatgcttc tgcgagaaga tgcttttttc gctttttatt 1022701 taaagcggta aggcttgcgg aagcgataat gcgtaaggtg aaaaaacgtc cgtatctgat 1022761 tttcagcttt ttgatgacgg gctctaagga ccagcattca ggacataaag ggtctacaaa 1022821 catataaatt tcaagcggtt tttttggatg accgtggcaa tgggcgaagt atagctcatg 1022881 ctgatagttt gtcaagatga tcgatcctcc gcttccgttt gattcaccat atgccttgct 1022941 gtcaactcca gccggccaaa caaaaactca cgaatttcgc cctccagccc tacatggtcc 1023001 attgcgtcct tcatacagct gagccacgca tcagctctct cgtttgtaat tggaaaggga 1023061 agatgccttg ctctgagcat aggatggccg tgttcctcag tataaagagg aggcccgcct 1023121 aaatactgag ttaagaattg cttctgtttc ctggcggttt ctgtcaaatc gcttggaaaa 1023181 atcggcttca gcaaaggatg agacgcgaca cgctcataaa aagtatcaac aagttgcgat 1023241 agaagttcct ctccaatcgc ttcataaggt gcgttaaacg attgtcccat gttgactact 1023301 cctttaaata tggctaatag gaatcataaa tcctattgca aaaagtaatt ttctgtattt 1023361 cattgtttca tctagattta ttttagcaac aaggcatcat ttctacaaac aaactgcctt 1023421 ttatgcgttt gatgactcat ttcggctgac agccggggtt tgtatttcat atcatatcac 1023481 ataaaaatca ggaatgcgta agatttcact tcgcaaaaaa accagaggga aagagcacct 1023541 ctggttacgc gtaataaact gaagttattt tttttacata gttttgcgtt tcttggaaag 1023601 gaggaatgcc tccgtatcgg tcaacattcc ccggtccggc gttgtaagcc gctaatgcca 1023661 tagacacatt gccgtcgtat ttatccagca tttgttttaa atatttcgtt ccgccctcca 1023721 cattttgctg cggatcaagc ggattggaaa cgccaagtga gcttgctgtt gacggcatca 1023781 gctgcatgag gcccatcgca cctgctccgc tgaccgcttt tgcattaaag cctgattcct 1023841 gtttgatgac ggcgcggatc agtttttcat caacgccata tttatcagcg gcttttttaa 1023901 tcgcactgtc aatagagaag tctcccgaac ggatctgatt tgcttcatgt ttgtttgaag 1023961 ctgaatctgc aacagctgtt tcagtgcttt ctgccgcttt tgtgactgaa cctgaattgc 1024021 tgctcgtata tgagttaagc ccatacgctg aaagcagtga cggcgctgtt gtattcgcgc 1024081 tgttcagcat gctgagcggg cttggcgatg aagaaggtgc tgattgctga gatgtcagac 1024141 cgtttgtata ttggctgagc aaagaactga aacttgaaag cgggctttcc gtattctgag 1024201 tgtccgagct gctgcgtgca ttagatatgg actgtaatgc ctgaagctga agtaatgctg 1024261 cccaattcgt tacattcacg atgtcattcc accttatata gactttcgtt tttcttcata 1024321 aaaacgcaga attttatttt tggtttcgcg ctgaggaatg ctgaattgct gaagcagctt 1024381 ttcgaaggct tgtctgccct catgccaatc cgccgcctca aattcaattt catagtcctc 1024441 tttatttaaa tatcggctgt ggtctaaaac tattaagcct ttttctgttt ctttttccgc 1024501 acggtttgtt gctaaagatc caaagtattg tatggcatcc gtatcgatct gaagcttgtg 1024561 cagctggtcc ttcacagggc cctcgggaac tgaaaatcca gcgagatctg atacctctga 1024621 aagctgctgg tgcgtttcca gaagccccac atcagccggc tcctttaatg taaggacata 1024681 ctttccgttt tttctgcgga tacgaagcgc agcatgtttt tgtttcagcg cgaagctgtc 1024741 tgtatcaaaa taatgattct tttgatctgt aaaatctttt tctgtcagct ggagtgccga 1024801 tgctatgttt ttgaattctt gtttggtcag catgttttta aattcgattt caatctcttg 1024861 gctcatgatg ctcttccttt ccgccctgta aatcttattt ttactattat ctctttagat 1024921 gttaggttta tcaatatcga gctcgatatg ataaaatgaa tctgtacttt gtttaaaaaa 1024981 ggagagcatt atgcaaaaca gaatcgaaat tttgaatgca acattatcgg atgatcagct 1025041 tcgccttgcc tgtcagacag aaggaaacga agcggaacgc aagccgtcag gtcaaatgct 1025101 tgttgattct gaccactttg cttttgtata catacttgaa ttagctgatt cttttgaata 1025161 tgtcattata aaggaacatg tatggccgga actgaagcag gcccatgcac aaaaaatacc 1025221 ggttgtttta gaggcaggag accaaacaat tgaactggca ggcctgcatg aggagctgga 1025281 atatctttta gaaaatataa aagataatgc aaactatgga gaagaaatgg aagaaaaagt 1025341 gaaacgcgtg tttttataga aactggttcg gaattggggg atgtatgatg gatgacaaac 1025401 aatgggagcg ttttttagtg ccgtaccgcc aggctgtcga agagttgaaa gtgaagctca 1025461 aggggatccg cacactatat gaatacgagg acgaccattc accgatcgaa tttgtgaccg 1025521 gacgcgtcaa gcctgtggcg agcatacttg aaaaagcgag acggaaaagc ataccgctgc 1025581 atgaaattga aaccatgcag gacattgctg gccttagaat catgtgccaa tttgtcgatg 1025641 acatccaaat cgtaaaagag atgctttttg ccagaaaaga tttcaccgtt gtggatcaga 1025701 gggattatat tgcggaacat aaagagagcg gataccgatc ataccatctt gttgtgctgt 1025761 accctttgca gacggtatcc ggagaaaagc atgttctcgt agaaatacag atccgtacac 1025821 tggcgatgaa tttttgggcg accattgaac attcattgaa ttataaatac agcggaaaca 1025881 ttcctgaaaa agtaaaacta aggcttcagc gcgcttctga agcggcttcc cggcttgatg 1025941 aagagatgtc ggagatcagg ggtgaagtac aggaagctca agctgccttt tcaagaaaga 1026001 aaaaaggaag cgagcaacaa taggtaaagg ggaagaagag catgaaattt gccgtatcat 1026061 caaaaggaga tcaagtttct gatacgctga aaagcaaaat acaggcgtat ttattggatt 1026121 ttgatatgga actggatgaa aatgaaccgg aaatcgttat ttcagtcgga ggcgacggaa 1026181 cgcttttgta tgcttttcac agatacagcg accgtttgga caaaacagca tttgtcggcg 1026241 ttcacacagg tcatctgggt ttttatgccg actgggttcc tcatgaaatt gaaaaacttg 1026301 ttcttgccat cgcgaaaacg ccgtatcata cagtcgaata tccgcttctc gaagtcattg 1026361 tgacctatca cgaaaacgag cgggaagaaa gatacttagc tttgaatgaa tgtacgatta 1026421 aaagcatcga aggaagcctt gttgctgatg tggaaatcaa agggcagctc tttgaaacct 1026481 tccggggcga cggcctctgc ctgtcaactc catcaggcag cacagcctac aataaggcgc 1026541 tgggcggagc gattatccat ccgtctatca gggcgatcca gcttgcggaa atggcttcaa 1026601 ttaataaccg cgtgttccgt acggtcgggt cacctctgct tctcccatcc catcatgatt 1026661 gcatgattaa gccgagaaac gaagttgact ttcaagtgac gattgaccat ttaacccttc 1026721 tccataagga tgtaaagtcg atccgctgcc aagttgcatc cgaaaaagtg cggtttgcga 1026781 gattccgtcc gtttccattt tggaaaagag tccaggattc gtttattgga aaaggtgaat 1026841 agaaagagga catatcgtgg agcatttttt tatcagaaag aacattactt ccgctgagga 1026901 cgggatgact gtaaaagaat atgccggtga actgggaatt tcgaaacgtc tgctgaccga 1026961 tattaagttt ggcgggggag acctgcagat taacggtgag catgtgacgg tcaaatacgt 1027021 tttgaaagag ggagatcttc ttatcgtgaa gtttcctgag gagcaggtga gcgagacgct 1027081 gttggcagag cctgttccgc tcgatatcct ttatgaggat gaacatgtgc ttgtgataaa 1027141 caagcagccg tatgtgtcat caatcccttc gagagagcac ccctccggca gcattgccaa 1027201 tggaattatt gatcattatc aaacaaccgg agtgagggcg acagttcatc ttgtcacccg 1027261 gttagaccgg gatacatcag gtatcatgct tgttgccaag catcgatttg cccactccat 1027321 tttatcgtct gcgcaaaaaa acggccttgt gaaacgccgg tatgcggcag tggttcacgg 1027381 gcggatggca cagatggagg gaacagtcga tgctccgatt ggcagacatc ctgacagtat 1027441 tattgaacgg acggtaacgc cagacggcca gaaggctgtt actcattttt acgtcacatg 1027501 tgcaaatgat gacatgacct cggtggcatt gcagcttgag actggacgaa cccatcaaat 1027561 tcgtgttcat atgagctatc tcgggcaccc gttgtgcggc gatacactgt acggcggaac 1027621 gagacaggaa attggccggc aggctctgca cagcgagcat ctttcgttta tccatccgct 1027681 gacacaggag aacatgaggt ttcatgctcc actgcctcag gacatgagca aactgataaa 1027741 aggagagaat cattgattct ctcctttttt atatggggcg aaatcttgat tcgtcgtaag 1027801 gcagggagct tggaacagag acggtttcta tttctggaaa gcgaaagcct gtcagttgat 1027861 ttccgaacac gcagcctgta tcaatgttga tggtgcgatt gaccttccga ggctctttca 1027921 caggtgtatg accgtatacc acccaagcct ttccgttata ggctgccgcc caatcacgcc 1027981 tgatgggtct gccgtccgga tatgtttcac ccgtcacgtc accgtaaagc acaaagtcct 1028041 tcactctgcg ggtatatttg ccgatatcgt cagctcttat gccagcatgg gcgacaacta 1028101 attctccatt atgtaagatg tcgtaaagcg gcgctgtttc gtacagcttc ataaactgtt 1028161 cgctgactga ttttttctca tctttggaaa gttcctcaag ctctgccgct gttgtttcga 1028221 gaccatgcat cacttttacc ggatttcctt ttaagtaacg atataattta ttgcaatggt 1028281 ttcccgggac ataacgcaca gcgccttttt cgtaagcgcc ggctacaaat cggatgacct 1028341 ctatcgattt gggccctctg tcagttaaat ctccggcaaa aacaagcacc ctgccttctt 1028401 catggacagg tactccattt ttgattgtat agccaagctt ttggattaat gcagtcattt 1028461 cgtcatagca gccatgaata tcgctgatga tatcgtaagc catgcggtct cctccttacc 1028521 gattgtttta tttattatga agcaaagtgt tgtgagtcat cacaagcttt tatgtgcaaa 1028581 ttatagaaga agaatcattt tctaaacagg attaagacct tatcacttta tttttcatca 1028641 tcacccttgt taaaatcgcg ttatgttttt taaaaatgag gttttgttct ctgagtgaga 1028701 actagcataa ccctgactta aaaaggaggt tctgattatg gcgcatacat ctgtcgcatc 1028761 tttagttgtt gtacttatcg ttgcattttt gacacccatc cttttgcatc ggtttaaact 1028821 cagcatcccg gttgttgttg ctgaaatcat tatggggctg ataattggga aaagcggcct 1028881 taatttagtt gtggagggtg acacctggct ccagacactc tctatgctcg gatttatctt 1028941 tttaatgttt ttaagcgggc ttgaaattga tttttcgtcg tttgagaaag gaaagaaaaa 1029001 gcagttcctg ccgaatggca aggaagcgcc gaatacgttt gctgcggcat ctgttatttt 1029061 cgtcggtatt tttattttat cattgctctt gtcctatggg ttcgtcttgg ccggatttat 1029121 ccaaaatgca tttttgatga ccctgattat ttcaacgatt tcattaggcg ttgtcgttcc 1029181 aacattaaaa gaagaacgga tcatgaattc gaatatcggg cagattattt tgcttgttgc 1029241 tgttattgct gatttggcca cgatgattct tcttgctgtt ttttcttctt tatacggaga 1029301 ggacagcgga aacatgtggc tcctgatgat tctgtttgcg gccggagtgg tgctttactt 1029361 tttcggccgg gtcttcaaac atcgctcttt tgttcaatcc atgtcaaaag ggacgatcca 1029421 gatcgggacg cgtgccattt ttacgttaat cattgtactc gttgccctgt ctgaatcact 1029481 tggggcggaa aatattctcg gcgctttctt agcgggggtt cttgtttccc tgctttcgcc 1029541 aaacaaagaa cttgttcagc agctggactc attcggttat gggttcttaa taccgatttt 1029601 cttcgtgatg gtcggtgtga agcttgatat ttggactctt ttccaggata aaacaatttt 1029661 aatcatgatt ccgctcctgc tgcttgcgct gttagtcagc aaaatcattc ctgtcatgta 1029721 cttaaagaag tggtatgata accgaaccat tttcgcgtct ggtttcctgc tgacatcaac 1029781 gctttcgctc gtgattgctg ctgcaacaat cggccagcag cttcacgtga tcagtacaaa 1029841 tatgtcagga gcgctaattt tagtagccgt cattgcaagt atttttacgc cgatctgttt 1029901 taaaaaatta tacaaacggg aagagcagcc ggaggagaaa aagacgatta cgttcattgg 1029961 cgccaatcaa atgactttgc ctgtcacact cgaattgcca gaggaagagt atgacgtgcg 1030021 tgttgtacac gtctaccaag agaatgcgga ggaaaagctg tcagaatcag tgtttgctgt 1030081 tgaaacaatt tctgactatg aacacgagac gcttgaatca ctcggcattt ttgaaacgga 1030141 tatcctcgtt gtggcgacag gaaatgaaga tatgaatgca gacattgcat tacttgcaaa 1030201 agataaaggc acagaaagag tcattgcaag cgtaggatca ccggagcatg aagcagctct 1030261 gaaggagcag ggaatcagca tcttttctat tctgctgtcg acaaaaacgc tgcttcgcgc 1030321 actgattgaa gcgcctggcg tcatgaagct gctcacgaac caagagtctt cgctgtatca 1030381 aattaatatg gagaacagta aatatgatgg tgtcatttta cgggaattcc ctttaacagg 1030441 tgacgtcatc tttgtcagga tcttcagagg tgtggacagc atcgttcctc atggggatac 1030501 gaggctgaaa cttggagacc gtttaattgt caccggatct cgggggtacg taacggatct 1030561 taagaaaaca ttggaaggat aaatcttgac caaataagga ttcgtgttaa tatagaggtg 1030621 cagaacaatt caatatgtat tcgtttaacc actaggggtg tccttcataa gggctgagat 1030681 aaaagtgtga cttttagacc ctcataactt gaacaggttc agacctgcgt agggaagtgg 1030741 agcggtattt gtgttatttt actatgccaa ttccaaacca cttttccttg cgggaaagtg 1030801 gtttttttat tttcagaggg ggaatgattt gtgaagtttt cagaagaatg ccgcagtgca 1030861 gccgcagaat ggtgggaggg gagctttgtc catccgttcg ttcaaggaat cggtgacgga 1030921 acgcttccga ttgaccgttt taaatactac gtacttcagg attcctatta tttaacgcat 1030981 tttgcaaagg tgcagtcatt tggtgccgct tatgcgaagg atctttatac aacggggcgg 1031041 atggcaagcc atgcccaagg tacatatgag gcggaaatgg cgcttcatcg cgagtttgcc 1031101 gagctgttgg aaatcagcga ggaagagcgt aaggcgttta agccgtctcc tacggcgtac 1031161 tcttatacat cccatatgta ccgttcggtt ttgagcggga atttcgcaga aatcttagcg 1031221 gccctgctgc catgctattg gctctattac gaggttggtg agaaattgct gcattgtgat 1031281 ccggggcatc caatttatca gaagtggatt ggcacatatg gcggtgattg gtttagacaa 1031341 caggtcgagg agcaaatcaa ccgctttgat gagctggcgg aaaacagcac ggaggaagtg 1031401 cgtgccaaga tgaaagagaa ttttgtcatc tccagctact atgaatatca attttgggga 1031461 atggcctatc gaaaagaagg ctggtctgac agcgccataa aagaggtgga ggaatgtgga 1031521 gcttcacgcc ataacggatg acagcaagcc ggtagaagag ctagcgagaa tcatcattac 1031581 gattcagaat gaagttgatt ttattcacat tcgggaacgc tcaaaatcgg cggcggatat 1031641 tttgaaactg ctcgatctta tttttgaagg cggtatagat aaacgaaaat tggtgatgaa 1031701 cgggcgcgtg gatattgcac ttttctctac tattcaccgc gtgcagctgc caagcggcag 1031761 cttttcaccg aagcagatca gagccagatt tccacacctt catatcggga ggtcggtgca 1031821 ttcactggag gaagcggttc aagcagaaaa ggaagacgcg gactacgtgc tgttcggcca 1031881 tgtgtttgaa acggattgca aaaagggtct tgaaggcaga ggagtatctt tgctgtcaga 1031941 tatcaaacag cggatttcca tcccggttat agccatcggg gggatgacgc cggacaggtt 1032001 aagagacgta aaacaagcag gggcagacgg cattgctgtt atgtcaggaa ttttctcttc 1032061 cgctgaacct ttggaagcag ccagacgata ttcccgcaag ctaaaggaga tgcgctatga 1032121 aaaggcatta tgaagcagtg gtgattggag gcggaattat cggttccgca attgcttatt 1032181 atttggcaaa ggaaaacaaa aacaccgcat tgtttgaaag cggaacaatg ggcggcagaa 1032241 cgacaagtgc cgctgccgga atgctgggcg cccatgccga atgcgaggaa cgtgacgcgt 1032301 tttttgattt cgctatgcac agtcagcgtc tgtacaaagg tcttggagaa gagctttatg 1032361 cattatccgg tgtggatatc aggcagcata acggcggtat gtttaagctt gcattttctg 1032421 aagaagatgt gctgcagctg agacagatgg acgatttgga ctctgtcagc tggtattcaa 1032481 aagaagaggt gttagaaaaa gagccgtatg cgtctggtga catctttggt gcatctttta 1032541 ttcaggatga tgtgcatgtg gagccttatt ttgtttgcaa ggcatatgtg aaagcagcaa 1032601 aaatgcttgg ggcggagatt tttgagcata cgcccgtcct gcatgtcgaa cgtgacggtg 1032661 aagccctgtt catcaagacc cctagcggag acgtatgggc taatcatgtt gtcgttgcca 1032721 gcggggtgtg gagcggaatg ttttttaaac agcttggact gaacaatgct tttctccctg 1032781 taaaagggga gtgcctgtcc gtttggaatg atgatatccc gctgacaaaa acgctttacc 1032841 atgatcactg ctatatcgta ccgagaaaaa gcggaagact ggttgtcggc gcgacaatga 1032901 agccggggga ctggagtgaa acaccggatc ttggcggatt ggaatctgtt atgaaaaaag 1032961 caaaaacgat gctgccggct atacagaata tgaaggtgga tcgtttttgg gcgggactcc 1033021 gtccgggaac aaaggatgga aaaccgtaca tcggcagaca tcctgaggac agccgtattt 1033081 tatttgcggc tggccatttc agaaacggga tcctgcttgc tcccgcaacg ggcgctttga 1033141 tcagtgatct catcatgaat aaagaggtca accaagactg gctgcacgca ttccgaattg 1033201 atcgcaagga ggcggttcag atatgatgct acagctgaac ggtaaagacg tgaagtggaa 1033261 aaaagacaca ggtacaattc aagacctgct ggcgtcgtat cagcttgaaa ataaaatcgt 1033321 tatcgtggaa agaaataaag aaataatcgg gaaagaacgc tatcacgagg ttgagctttg 1033381 tgatcgtgat gtcattgaaa ttgtccattt tgtaggaggc ggatgagcat gttaacaatt 1033441 ggcggaaaat catttcaatc aagattgctg ctgggcacgg ggaaataccc atcgtttgac 1033501 attcaaaagg aagcagtagc tgtttctgag tctgatattt taacatttgc tgtaaggaga 1033561 atgaacattt ttgaagcatc tcagccgaat tttctggaac agcttgattt atccaaatat 1033621 acgcttttgc cgaatacagc gggcgccagt actgctgaag aagcggttcg gattgcaagg 1033681 ctggcgaaag cttcaggcct ttgtgacatg attaaagttg aagtcatcgg atgcagccgt 1033741 tccttgctgc ctgaccctgt tgagacatta aaagcgtctg aacagcttct tgaagaaggc 1033801 tttattgtgc tcccgtacac gtcggatgac gttgtgctgg cgagaaagct ggaagagctc 1033861 ggcgttcatg ccatcatgcc gggtgcatct ccgattggat caggacaagg aatcttaaat 1033921 cctttgaatc tgtcgtttat tattgaacag gcgaaagtac cggtcatcgt ggatgcggga 1033981 atcggctcgc ctaaagatgc ggcatacgca atggagcttg gagcggatgg cgtactgctc 1034041 aatacggctg tatctggcgc tgacgatccc gtgaaaatgg ctcgtgccat gaagctcgca 1034101 gtggaagcag ggcgcctttc ttatgaggcg ggccgaatcc cgcttaagca atacggaacg 1034161 gcaagcagtc cgggagaagg tcttcctgta tgacaggcag gtattcaagg caggagctgt 1034221 ttgctccgat cggcccatcc ggccagaaaa aattgaaaga agcgcgcgcc gtgattatcg 1034281 gcgccggcgc gctcggaaca gccagtgcag aaatgctggt gagagcggga gtcggctctg 1034341 tgaaaattgc cgacagagat tatgttgaat ggagcaacct ccagcgccag cagctttata 1034401 cagaagatga tgtcaaaaaa gaaatgccga aagcagccgc tgcggagcgc cgtctccgtt 1034461 cgattaacag cgatgttgat gtgaccggcc ttgtcatgga tgtgacagca gaaaatatct 1034521 tcgagctgat tagggatgca tcgattattg tggatgcggc tgataatttt gaaacccgcc 1034581 tgatcgtaaa tgatgctgcg gtaaaggaag ggattccttt tctttacggt gcctgtgtag 1034641 ggagctacgg tcttaccttt accgtggtgc cgggttctac tccttgcctg cattgcttgc 1034701 tcgatgcact tccgattggc ggagcaacat gtgacacagc tggcatcatc agtccggctg 1034761 ttttgcaggt agcagtcttt caggtaacag atgcactgaa actgctgacg ggagaggagt 1034821 gcgagccggt gctgcgctcc tttgatttgt ggaaaaacga gcggtcagaa gtgagagcgg 1034881 ccagtctcaa acatgacgca tgcccaagct gcggcacaaa ggattttccg tttttgtctt 1034941 atgaaaatca aacaaaagcg gctgtattgt gcggcaggaa cacggtgcag atcagatcat 1035001 ctattacgaa agaagcggat cttgaagcgc ttgccggtca gctgaggcag gccgggcttg 1035061 aagtagctgc gaacccgtat ttaatttcct gccgctcgga tgatatgaaa atggtgctgt 1035121 tccgggacgg cagagctttg atccatggaa caaatgatat tgcccgggca aaatccattt 1035181 atcataaatg gattgggtaa taaaaggagt gtagtgtaat gagtatatat aaagcattga 1035241 caatcgccgg atcagattca ggcggcggcg cagggataca ggctgatatt aaaacctttc 1035301 aagagcttga tgtattcgga atgtctgcga ttacggcggt aaccgctcaa aatacgcttg 1035361 gcgttcacgg ggtgcatccg ctgactgtag agacgttgag acagcaaatt gacgctgttg 1035421 ctgaggattt gagaccggat gcagttaaga cgggaatgct ctggaatgcc gacatgattg 1035481 aagaagtggc aagaaaaatt gacgagtacg gattcaatcg tgtaattgtt gatccggtta 1035541 tgatcgcaaa gggcggggca tccttgctgc gtgatgagtc agttgccacc ttaaaggagt 1035601 tgctcattcc aagaagctac gcgattacgc cgaatgtccc ggaagcagaa acgctgacag 1035661 gaatgacaat cagctcgctg gatgaccgga aaaaagcagc ggagcagctc gtcaagatgg 1035721 gtgcgcagca tgtcattatc aaaggcgggc accagcctga ggacaatcac attactgacc 1035781 ttctttttga tggcagcatg tttatgcaaa tcacccatcc ttatatcaat acgaagcata 1035841 cgcatggcac aggctgcacc tttgctgcgg ctttaacggc ccaaacggct aaaggagaca 1035901 gcatccatca ggcatttgag gttgcggcca actttgtccg tgaagcggtg gaaaatacgc 1035961 tcggcatcgg atcgggacac gggccgacaa accatttcgc ttttaaacga aacagcttaa 1036021 atacaagccg atgagatcac cagctgatgg tgatctcttt tgcgtttgct acggtatgcg 1036081 cttttcatct ggacaaggtt atgatatgat aggaattaag atcaggtact aatactatgt 1036141 ctttattaaa tataggaggc tttatacata tgaatttttc acttgaaggc cgtaacattg 1036201 ttgtgatggg ggtagccaac aaacgcagca tcgcctgggg cattgcgcgt tctttacatg 1036261 aagcgggtgc acgtttgatt ttcacatacg ctggtgaacg cctggagaaa tccgttcacg 1036321 agcttgccgg aacattagac cgcaacgatt ccatcatcct cccttgcgat gttacaaacg 1036381 acgcagaaat cgaaacttgc ttcgcaagca ttaaggagca ggtcggtgta atccacggta 1036441 tcgcgcattg tatcgcgttt gccaacaaag aagagcttgt cggcgagtac ttaaacacaa 1036501 atcgtgacgg cttccttttg gctcataaca tcagctcata ttctctgact gctgttgtca 1036561 aagcggcacg tccgatgatg actgaaggcg gaagcattgt cactttgacg taccttggcg 1036621 gagagcttgt gatgccaaac tacaacgtca tgggtgtagc aaaagcttct cttgatgcaa 1036681 gtgtgaaata tttagctgct gacttaggaa aagaaaatat ccgcgtcaac agcatttctg 1036741 ccggcccgat cagaacatta tctgctaaag gcatcagcga tttcaactct atcttaaaag 1036801 acatcgaaga gcgtgcaccg cttcgccgca cgacaacacc tgaagaagtg ggcgatacag 1036861 ctgcgttctt gttcagcgat atgtcccgcg ggattacagg tgaaaatctt cacgttgatt 1036921 ctggtttcca tatcactgcc cgctaagcag gctgttaatg atgcaagggc tgtcttgctt 1036981 tctgtagcag gggatacaaa aatcttgagc ggttggctgt tttgccgcgc ctgttagcag 1037041 ggcaagacaa atataaatgc tgtttcgccc gggtcatggc tacatataaa aggcgtcttt 1037101 cctcctcaag agcggcctcg tctccttttc ttgccgtttc taatgagaaa tcgtgcggaa 1037161 tcgagccatc tacagtgcct aacacgtaga ctgttttgaa ttcaaggcct tttgaccggt 1037221 gaatggtcat cagctgaacg ccatgttcat ccgttctgtt tttctcagcg gccctcatat 1037281 ggtctacgtg ggcaagaaag tcaggaatcg ttttgaactt cttggcgaca accttgatgt 1037341 cgcgcaggtc atcagagcct ttttccagct tgttgccctc attgccccgc ttttttaaat 1037401 actcggagaa gcccattttt ccttctgcaa aggtgatggc ttctacgggt ttcattgtgc 1037461 ggaggcttgc aaaaaacggt acgattttct tgattttgtc cagctggaat ggcttcagat 1037521 caggcaattt ggccagcgct ttgatcatgg tacagtcctc tgtaatcgag agcgccttca 1037581 gcgtattcaa agcggactgt tttaaaaaca aggcgggaag caagtgttta atcgcctcgg 1037641 tgtcatcctc attttggctg gcgtacaagt aggcgagaat ctggcggacg atccgtctgc 1037701 tgtaaaacga ttggacgccg cggtcagctg tatacggaat tgacgattga tgaagccttt 1037761 catatatagc acggcctccg ctgtttgtgc ggtaaagaac cgcaaagtct tctggactgg 1037821 ctccattttg aattttttct ttgatatcgg aaacgaccat tgtggcttct tcctcttcat 1037881 cataaggata aaacagcaca gggacctgaa tgtcatcgcg ggccgcttca agcgttttgg 1037941 catatctgtt tttgttcttt ttcacaacga tatcagcact agagacgatc gggtgcgtag 1038001 acctgtagtt cgcagttaaa tagatcgtct tcgctcccgg ataatccttt tgaaaatcaa 1038061 gaatgaaaga cggattgctt ccgcgaaacg cgtagatgga ctggtcatcg tctccgacac 1038121 agcacaggtt ttgctccggg ctggcgagca tttgcatgat tttgtattga accggattaa 1038181 tgtcctgaaa ctcatcaatt aagatatacg taaaccgaga ttgatattgt tccagaaggt 1038241 caggccgctc gataaacaat tcatagcagg ctgaagccat gtcatcaaaa tcaaattggc 1038301 tgtgttcttt tttctggcgt tcataatgtt catataaacg ataaacttgt ttttcccact 1038361 catcttttag agggatgcgt tcatttggga cataagtgtt tttccaaaaa ccgatctgct 1038421 gcagggcttg gtcaactggg gattctttct catcgatgcc ttcttcatag agtgcttttt 1038481 tgatatattg ttcccgctgc cactccattt tcagcagatg ctcaccgttc catttagcag 1038541 aattagagtg atacaagatc ttataaaaca gactgtggaa tgttcctgtc acaattcttc 1038601 tgacttttgc cggctgtaat ccgtactggt tcgccatacg ctctttcatt tcagcgacag 1038661 cttttgttgt aaaggtgaca agcagcatat tttcaggcgg tatgcctaag tgttcgatca 1038721 tgtgggcggc acgggctgtc agtacccgtg tttttccgct ccccgcacct gcaagcacga 1038781 ggagcgggcc ctctgtttcc gtgacagctt tcagctgatc cgtgtttaaa ccgacagacg 1038841 gaaaaaggct cgtatcgggt tctattgttt ttggcacaaa tggtgttcct ggtttaatgc 1038901 ttctaggacg gtgccattct gtaacagctg gggacgggtc agcggcgatc gcttttccct 1038961 tgggtaaacg aatgacacca gattcctgat catcttcttt tttcccctct ttagagggct 1039021 tcggttcgca cgcctcctca catgccggaa aatcgcctgg ctggcgatgg ataaactctg 1039081 gcggatcggc gatgttaagc cgtaacaaaa cgggctttcc gcaatgagaa caaaataaat 1039141 gtccttttat tccctcttca aagaggaatt gataatgttc tctcgaatat gtatgtaaat 1039201 gtatgattct atcattcagt cgggcgcatt tcaaaaaggg gtcctcccaa tcaaaaggtg 1039261 ttcattacag acaatgacta tcatatcaaa agaaatgtgt ttcaaaaagt aagtttaagg 1039321 gaaaagagac agcagagggg tgggtattgt atgatatatg caggtcaaat tcagaaccag 1039381 caatacgctc aatatgctaa tagaacgatt ggacataagc aggattatgc cggaaccgaa 1039441 aaaatcagct atgtcccgtt tcagcgggta tacaaagaac tggaaaagca gcaggagaat 1039501 caaacggcag ctgaaagaaa agtaaacgag atgaaacgta agcgctctct ttataagaga 1039561 ttgcgagaaa aaggaatggg gacatatatt aatcgatatg tataaaaaac cgttcatacc 1039621 agagaacggt ttttttatat gcagtaaaaa tccggatctc aaaagatccg gatgcgttca 1039681 gtccttcatc atttgtaagt gcggaatgcc ggcatcgagg aattcttttt cagaaagcac 1039741 gcgatacccg tgtttcttgt aaaacggcac agcctgtgtt tgcgcgttta aaatgaaacc 1039801 ggaagcgcct ccgtctgccg cggctttttc gagcgctttc ataatgatgc cgccgacacc 1039861 ggctgagcgg tggcttttca gtacgcaaat ccgctctaac ttgccgtagc cgtccttcat 1039921 gcgccatctt ccggcaccga caggcttttc accgtcatac acgacgatat gctctgactc 1039981 attttcaagt tcgtcaattt cttcttcagc aggcacgttt tgttctttga caaagacttc 1040041 ttctcttaca tagaatgcat ctttcagttg ttcttcattt tttgcgataa ctgctttcaa 1040101 acattattct cctctgccta gcaagaaggt ttcatatact gtccacgatc cgttttccaa 1040161 ctggtagagc aagtggaaac ggtcaacgat ttcttcatgc gacacttcct gcatttttaa 1040221 ttgtcccagc acatctgaat gctcatcgtc ggaaagattt tggccgaccg tcacatgcgg 1040281 aacgaaatta tattcctgtt ctcctgccaa cacaccggtg tatagctttt cattgagtgt 1040341 ttttaactct tccgtcggtt ctgctttgat gtaaatgaca ttattgacag gcgcaaatga 1040401 gctgtatttt gtcattttga gaacgagtgg gtgggactct tttgcgatgt ttcttaaatg 1040461 tgatacgagc tgatccgctt tctcctccgc gcattcaaag gatgctctca gcgtcaaatg 1040521 aggcgggatt agagagtagc ttgggtcata gcgctttctg taagagtttg caaggtcttg 1040581 gagctttttt gatggaaata aaacgattcc gtatttcata ttatgtccct cctggaaata 1040641 aagtatgata gagtgttaaa gcattttttt cagcgccggg gtgatgagcg gctgccagta 1040701 tgtccatttg tggtctccgt caaatggctc gaaatcataa tcggaaagct ttttctccag 1040761 cagctgtttc agctcccggt tcggttctgt aaagtccaga atgttcccgt ctgtcgtgtg 1040821 gacgtcagtt tcttttgttc cgatttggtg ataaatagag aggtgtttga tatcgtctga 1040881 ctgttttacg gcttctagta cgtgtttgtc aacataggga gactgcatga tgatgttgcc 1040941 aaacatattc ggataatcaa gcgctgtcat aagtgacacg gttgctccga gcgaatcacc 1041001 gatcagcgtt cggccgtaac cgatctgata ggttggatac tcatcatctg caaaaggaac 1041061 gagctcatgg gcgatgaacc gtttataagc cgaaaatttt gaaccctccg gatgataagt 1041121 gtttctgcgc tcttttacat ccttataggg aacaccgata ataatgctcc ggtctatttc 1041181 gcgtttcgac agcaattcct caacctgtct gccgattctc cccagcctga aataatcgtg 1041241 gccgtcctgc gcgataatga catggtattt ataaagcggg gagtagttgg acggcagata 1041301 aacaagcaag gtcatttcct cgttaagctc ttttgaaaag aatttctttt cttgcactgt 1041361 gccgtttttc ggtgccataa aaacattcct ccaggacatc actatacttt cttgcatttt 1041421 caattattgt accatgaatt attagaaatt tctctcttta aacggttcgg cacacgaaga 1041481 aaaaagtgtt gaaataaact gtgaattgcg ctaatataaa acaatcagaa aattgaaatc 1041541 gatatttctt atcgtgagag gtggagggac tggcccttag aaacctcagc aaccggcttg 1041601 ttttgcattt gcaaagcgcc aaggtgctaa atccagcaag cgttttttat gcttggaaga 1041661 taagaagaag cgttaaaccc cttcttctta tgaagaaggg gtttttattt tgaaaaggga 1041721 aggtgtcagc tatatgtcac agcacgttga aacgaaatta gctcaaattg ggaaccgtag 1041781 cgatgaagtc acgggaacag tgagtgctcc tatctattta tcaacagcat accgccacag 1041841 agggatcgga gaatctaccg gatttgatta tgtccgcaca aaaaatccga cacgccagct 1041901 tgttgaggac gcgatcgcta acttagaaaa cggcgcgaga gggcttgcct ttagttcggg 1041961 aatggctgct atccaaacga ttatggcgct gtttaaaagc ggagatgaac tgatcgtttc 1042021 atcggaccta tatggcggca cgtaccgttt atttgaaaat gaatggaaaa aatacggatt 1042081 gacttttcat tatgatgatt tcagcgatga ggactgttta cgctctaaga ttacgccgaa 1042141 tacaaaagcg gtgtttgtgg aaacgccgac aaaccccctc atgcaggagg cggacattga 1042201 acatattgcc cggattacaa aggagcacgg tcttctgctg atcgtagata atacatttta 1042261 tacaccggtc ttgcagcggc cgcttgagct gggagctgac attgtcattc acagcgcaac 1042321 caagtattta ggcgggcata acgatctgct tgctggactt gtcgtggtga aggatgagcg 1042381 gctcggagag gaaatgtttc agcatcaaaa tgcaatcggc gccgtcctgc cgccatttga 1042441 ttcgtggctt ctgatgagag gaatgaagac gctgagcctc agaatgcgcc agcatcaggc 1042501 aaacgcgcag gagcttgcgg cgtttttaga agagcaggaa gaaatttcgg atgtgctgta 1042561 tcccggaaaa ggcggcatgc tgtccttccg tctgcaaaaa gaagaatggg tcaatccgtt 1042621 tttaaaagca ctgaagacca tttgttttgc agaaagcctc ggcggggtgg aaagctttat 1042681 tacataccct gcgacccaga cgcacatgga tattcctgaa gagatccgca tcgcaaacgg 1042741 ggtgtgcaat cggttgctgc gcttttctgt cggtattgaa catgcggaag atttaaaaga 1042801 ggatctaaaa caggcattat gtcaggtcaa agagggagct gtttcatttg agtaaacaca 1042861 attggacgct ggaaacccag ctcgtgcaca atccatttaa aacagacggc ggaaccgggg 1042921 cagtcagtgt accgattcag cacgcctcga cttttcacca atcttcattt gaagagttcg 1042981 gggcatatga ttacagccgc tctggcacgc cgacaagaac agctctcgaa gaaacaattg 1043041 ccgcactgga aggcggaaca agaggatttg ctttcagttc aggcatggct gccatctcaa 1043101 cagcattttt actgctgtca cagggtgatc acgttcttgt gacagaagat gtatacggcg 1043161 gaaccttccg tatggtgaca gaggtgctga cccggtttgg cattgagcat acgtttgtcg 1043221 acatgacgga tcgtaatgaa gtggcgcgga gcatcaagcc gaacacaaag gtcatttata 1043281 tggagacgcc atcaaatccg acacttggga ttacggatat taaagcagtt gttcagcttg 1043341 caaaagaaaa cggctgcctg acctttctgg acaatacatt catgacgccg gcactgcagc 1043401 gtccgcttga tctcggcgtg gatattgtac ttcacagcgc gacaaaattc ttaagcggac 1043461 acagcgatgt gctctcaggt ttggctgctg tcaaagatga agagcttggg aagcagctgt 1043521 ataagctaca aaacgcgttc ggcgccgtcc ttggcgtgca agattgctgg cttgtcctgc 1043581 gcggattaaa aacattgcag gtccgtttag agaaagcgag tcaaacagct cagcggcttg 1043641 cggaattttt ccagaagcac ccggcggtca agcgcgtgta ttatccggga ctggctgatc 1043701 atcccggcgc tgaaacccat aaaagccagt caacgggagc gggcgccgtg ctatcttttg 1043761 agcttgaaag caaagaggcc gttaagaagt tagtcgagaa tgtgtcactc ccagtcttcg 1043821 ctgtcagcct tggcgccgtg gaatcgattt tgtcctatcc ggcaacgatg tctcatgcgg 1043881 caatgcctaa ggaagagcgt gaaaaacgcg gtatcactga tggcctgctc cgtctgagtg 1043941 tcggcgtcga acatgcagac gatttagaac acgatttcga acaagcgctg aaagaaattg 1044001 ctccagtttc ggttcgttaa aaaagaagcc ggggatagtc cggcttcttt tattattgtt 1044061 cgtcatcagg attcagaatc gcgaggactt gatgatcctc ccaaacgcca ttaattttta 1044121 cattttttcg ggcgatgcct tctttatgaa atcccgcttt ttctaaaaca cgcatggacc 1044181 cgagattacg gggcatcaca ccggcttcaa tccgatgcag tttcaattcg tggaacgcat 1044241 aatcaacaac caatctgact gcctctgtca taatgccctt tccattatgg gctttgtcta 1044301 aaaaataccc gatgaacgca gtttgcagcg cgccacggat gatttgaaag agcgaaaccg 1044361 tcccgattaa tctatcgtct gacgctgtaa agatgccaaa atgatattct tcatctttct 1044421 caagtctttc ctgatactcg gttattcgtt ttctttgccc ctcaaccgta tagtaatcgt 1044481 ctgcgcgtat catagaaaac tgttcgaaaa aatctcgatt ttcgctttgc agccccagat 1044541 tttcttcggc atccgttact tctaaaggtc taacataaat ggtttttcct tttaacatat 1044601 agtgatctct ccgttctcat gtcagcattc ctcttacatt attctcaggg aaatgcaaat 1044661 atccttttta taagaaggaa gaaaaccaat ttcccataaa agtgccaaca tagttgccga 1044721 ttaagtagcc gagcgtaccg acaagcatga tcggggcgac aagctcccgc catcccttgg 1044781 caattgccat cgcagccgca gtcgtcggtc ccccgacagt agcgttgacg gcgagcagaa 1044841 tttcttcaag ccgcacacgg aacaattttc cggcagctaa ggaaaccgct aaattgctaa 1044901 tcgcaatgat aaacacgaat aatagaataa gaggcgcatt cgtgacgatt aagcggagat 1044961 ctgcaggaat gccgatcacc acaaaaaaca aataaatcaa aaaggttcca agctcctgag 1045021 atccattgag cctttcaaaa aaacgcggga aaagaaaaat gataagaaca gttaaagacg 1045081 taagaaccag gtactgatcg ccaagcgtac cggtcagcag gggatgagaa aaaatgcttt 1045141 taaaataacc ggaaaccttc atactaaccg caacaagcgc gaaagcggca ccggcattaa 1045201 aagcgatatc ctttaaggaa atatccttcc gtttccaata gctttcagca ctgtttccgc 1045261 tgtttccatc ggcttttacc ttctcttcaa acggcatggc ataatgccgc tgaaaccatt 1045321 tgagtgcagg aatgctgatt aaaataaaaa acaaaagcgc catcataaaa ttatcagcca 1045381 caacggtagc cgacacatat tcaccaggcg tctcaaattt tgccgccatc gccgcaaagt 1045441 tgaccccgcc gccgatataa gaggcgctga tcatcccacc gattttatct aagtaaggaa 1045501 tatgctgttt gagtagaaaa aaagccagga tactgccaag cactgttcca acggagctaa 1045561 tcagaaaaat aaacagcaaa cgcctgcttt ccttaaaaat ttgcctaaca ttgatctgaa 1045621 acaataaaag tggtatcgcc agcggtacca cataagacca cacagtgtca tacacgggcg 1045681 actcaacagg aagcactcct acatttgtaa acaccatagc acctgcaagg gcgataatag 1045741 cgcccgacac agcagacgcc cacttaaagc gctgctccag cccgatgctc actgccgccc 1045801 acaccgcaat aaacccccat aatacccata catcatcaga agaaatcaaa gaatgcaaaa 1045861 ccccatcacc tctattgtta gaaaattaag acatattata atagccgggg aacggaacag 1045921 caagtccaaa aaaagttttt ctaaaaaagc agttgacgaa tagaaggtaa ggttatataa 1045981 tagaacttgt cagaaagata acaacatacc cagcaacaca tacatatcat gattccgtag 1046041 ctcagctggg agagcgctac cttgacaggg tagaggtcgc tggttcgagc ccagtcggaa 1046101 tcatagctta aacccttgcg cagcaagggt tttttacttt gcgttaataa agccggttcg 1046161 tcaaattcgt gagttgttgg cgaactgttg gcgaaattca ttgaccgcag tccaaaaact 1046221 acctccaaac ttacttgatt agttcaatag taacaaacgg aagatcggat ttctgttaaa 1046281 tcttcattga gaatagccag tccaagaccg tcacttcagc catgcatctt ttaaatgaaa 1046341 ttttgtactg aaaacatcaa ttgtattttt aaattctgct ctagaatcag cccctttata 1046401 ataatcttga taaattgctt ggggtgatac tgattcgtga tttgtgctat ggtttgcaag 1046461 gcttgtagca aaagcaggag caacagtaac gagtaaagca agggataatg caaaaccagt 1046521 taaagctttt tcaatttcat tttaagcact tcttttttta aaatacaact ttattattaa 1046581 atggaataca aaaacatcca aggtgttttt ttgttagtaa gttgagttag ggggattgga 1046641 tggcacttag aatattgttt ctgctgatgg gatgttgatt ctggatatat ttccaacacg 1046701 attacaggcc ggacatgaaa gcgaaccttg ctttgatcgg ggcaatcatt tcatttacgg 1046761 ctgcggttta ctttaaagat attgatgtat tgagagaaga gggaaaacaa atgaacggaa 1046821 tttctgagcg ttggaacacg tttaaattac aaaaatcccc tgaaccactc tagatcaggg 1046881 gattgctttc ccaacagctt attaagtagc ggaaggcatg atcaacgatt tagtatcaat 1046941 ttattaattg cgaatactag aaacataccg ttttccgcct tccttagaag taacatattc 1047001 tcgaggaaca ttaagtctat tggtagaatg ataacttaca taaagtttca tatttgctcg 1047061 gctcgttacg atagccgtat gatccatcca accatcagca tagcgaagac ctattttatt 1047121 atggtaatca tagtgatata catctccaag ctttacattt gaatatgtat cagaaacagt 1047181 cttcattttt attccgccag cttttaaaat gtatgatcta aaggctcctg cattaaccca 1047241 agcatctgta tagggtttcc attctttaaa gtacggcatt cttccagctc ttaatgcttg 1047301 ggaaacaaag ttagtacaat ctttgtcttt ataatattta tagtttttat ttggttttaa 1047361 ggcatatttt tctgcatatt tcattgcagc gtaaccacta tatcctttaa cagatgttgc 1047421 agtcacagtt agttgattag agttagcagc attgaagttc atacttactg gtttatcttc 1047481 acttttcact tcttctttat catcattttt cacttcttgc ttatattttt ttaaaaattc 1047541 atctaattta acatccgaag aatattcttc atcattttca tattgtagag ttgaagaaga 1047601 attatttaat tgtgttacat ttagttgctt agaagaatta ctcaatggta ttacatttag 1047661 ttgattagaa gaatttttaa cttgagagaa acttagatta gaagtatttg ttgattgaga 1047721 actttgttta ttagaagttg ttttgggaat ttcaagttta atattatcgc ccagagatgt 1047781 tgttactttt tcaacaccaa aaacaaagtt tcgagtaata taagcttcaa caattagctt 1047841 attgtttttt tcagaagtct taacatcgtc tatatcgtat gtaaactcgt ggaatttttg 1047901 tttgtccact ttacttaacg cagaatacag taagactcct tcgtcggaat cagtcaattt 1047961 agactcttta ggatgcgcta aaggagtgtt gtgttcaaaa tcatattttt gttgttctaa 1048021 catatcctta actttttcgt aaccaatctc gttggtaatt gaaacatttt ctttagtctc 1048081 tttattagta gtggctgcaa aaacttcatt tgttgacact aatggtgaca atgatagaca 1048141 taaaactagt gaagcaagta attctttttt catacgaaac ctccaataaa atctaaatat 1048201 aagtaatatt tatcatttac accaattgaa atatggcata aaatacatgt aataatataa 1048261 cataaaaata aatacataaa aaggtatcgg aggaaaaaat gaaaaagaaa actaaaatta 1048321 tactttctct cttggcagca cttattgtta tattgatagt acttccagtt ctatctcctg 1048381 ttgtctttac agcttcttcg gaaaaaggag caatcagaca cgaaatttat aaaagaggat 1048441 atccctacca aagctacttt gcagttctcc agaaaagaga aggagacaat gaatctggga 1048501 atctttatta tgtaaattgg ctagattgga aagatgaaac agggcaaact cctcacttat 1048561 gctattcgaa aaaatcatca gatggtgaat acgaagtaag ttgtggcaca gggccgtaaa 1048621 aataaatttt aaaattgaat aagtccaaga cggaaagcct gcggacactg atcgttttac 1048681 agagaaattt gtgcttcgat cggtgtccgt tttttttcgc aactaaccag atgtctatcg 1048741 cgattactag ctatgaaagg agtaattaga catgaaacag tccaaaaaga aaccatcaca 1048801 gaagcaacat gagcgcttag atcgtttctg gcaacaaatg atgaacacta acatgcaaac 1048861 actcagacgt ggcaaaggcg gcgcttataa acgcagaaag taaaaaggga gtttgaggat 1048921 gatgaaaaac ggattcgctt ataaaaacgg aaagcttgtg aatatctttt gcggcaaaga 1048981 agagctctat aacgagttga aagccttctt ggtcaaaacc ttcagtatca acgtgaaaga 1049041 ggtatcgagg ccctcaatat atcgcagaac aaaaagcaaa caactggaat gacacttact 1049101 ctatttaact atcaggaggg aaagcactat gacagatcaa atgattgcat gggagattga 1049161 ggaatggatt cgtgattata aattcatgct gcgggagatc aaaaggctca accgtgtatt 1049221 aaacaaagtg gattttatta gcacaaagct cactgcaaca tacggggagg aagcgggcat 1049281 gccaagggga tcagcaggcg tcagtcaggc agaattgcgg cagatggacc gaagagaaag 1049341 gcggcttcac aaatatgaat ctattgtgca ttacctggac aatgcaatgg aacacattga 1049401 agaagaaaag caccgaatcg tttacgattg catgatggaa ggcatgagct acactgctat 1049461 tgcaaaccac cttgattgct cccgggatac catcagaaag atcaaaacag ccataatcgg 1049521 caacatcgtc aataaagtca aagaagccaa ctttctgcaa tatttgaatt cgtttaaatc 1049581 ggcggtgtaa aatggggggc aggatcggcg cggcggatta ttcctgcgtc accaccaatt 1049641 tcatacaatg agtaaaacct cccagtggta agcgaggatc aactcaactg ggaggtctta 1049701 catagtgaat cggtgataaa acagcagcag tattgcgtac atgttaatat ccccgacaaa 1049761 atatgttttt ttcaacagat tcgttcgaca aattttgcaa attgttaatc gataactttt 1049821 cattcccgat attaaaaatg ggagtgaatt gtaaaatgaa aaaacagaaa aataataaaa 1049881 agaagaatat tgaaaagcga aatattgaaa agcgaaatat tgaagagaag aataatgagg 1049941 acttagaaga actggaaaat gcgatttata cttatcacaa aaaggagcta cttgctttct 1050001 ttcttgaaaa aactcgaatt ggtcatgata aggaagaata caaaaggttc caatctcttc 1050061 tttataagtt ggatattgaa tgtttagaat ttgctatatc gagattttct catatagata 1050121 ttatccatga tcattcaaaa tatgttccag cctttatccc tttatttgca gcatatctca 1050181 ccatgttctt taatttttat gaaaaacatt ggggagcttt atcttttgct gctggtacaa 1050241 ttgctgctat tgtttggata attgcagtag aaagaaaaca tagaaatcaa gcaatttcta 1050301 ttatgaaaat atttgaacaa gtcaaagaga gaaaagtgaa agacagatct aaagactgaa 1050361 aggagaaaat atgaataagg ataaattaag gtatgcaatc ttaaaagaaa tttttgaagg 1050421 taatacccct ttgtcagaaa acgatattgg agttactgaa gatcaatttg atgatgctgt 1050481 gaacttttta aaacgcgaag ggtatatcat tggggtccat tattcagatg atagacctca 1050541 tttatacaaa ttaggacctg aactgacaga gaaaggtgaa aactacttga aagagaatgg 1050601 aacatggtct aaggcctata agaccattaa agagattaaa gattggatta aataataaga 1050661 gcatcctgcg gggtgctttt tttgttccct gtaaactgct tccggtaagt ctcaggatag 1050721 acaattggcg gttaacggct tgagcacggt ggtggtttag agggaatatc ttttccaaaa 1050781 caacacgaat cagaaggggg cggcggtgaa tgtagatggc cgaaaagcac attcaggcgt 1050841 ataaggatta cgtcaaaggc atgaaataca aggaccttgc cgagaaatac ggggtgtcag 1050901 tgaacaccat taaatcgtgg aagcagcggc atggttggga aaggaaaaag ggtgcaccca 1050961 ttgaaaaaag tgtgcacaca aaaaaaggcg ggcaaccggg caacaaaaat gcattaggga 1051021 acaatggcgg cgcaccacag aagaatcaaa atgctgtgac tcacggcttt ttctctaaat 1051081 tcttgccaga agagacgctt gaaatcatgg aagagattca ggagcgttcg ccagctgata 1051141 tgatatggga tcagatacag attcaatatg cggccattct tcgggcgcaa aagatcatgt 1051201 tcgtttctga taaggaagaa atgatcaaag agctgaaaaa gaaaaggtcc ctcatatctg 1051261 aggtcagcga aattgaagat gggcttgtca ttagttttag tacgtggttt cgctacagac 1051321 tttacagtga aacaaacacc taacacattt cacattgctt cagattgcct tcaaacttga 1051381 taatataact tctaaacctt cctataaaat gaaggttttt tatttgattt caatttttaa 1051441 atcctttaca tacagcgatt gattaactcg agcaatcaat gtcgcagtta tatttatttt 1051501 tcaagaaaat gttataatga aaagccataa aatgatggga gggggaattt cgatgcatta 1051561 cataacggca tgtttaaaaa tcatcagtga taaagacctt aatgagataa tgaaggaatt 1051621 caaaaaactt gaggaagaaa cgaacaaaga agagggttgt attacattcc atgcttatcc 1051681 gcttgagcca tcagaacgta aaataatgct ttgggagatt tgggaaaacg aagaagctgt 1051741 gaaaatccat ttcacaaaaa aacacacaat agacgttcaa aaacaagaat taacggaagt 1051801 agaatggtta atgaaaagca atgtgaatga ttgaaaggct ctttaaaaag agacattcaa 1051861 tgacttagta tcagccactt gtgactaagt agtaaattgt tgtccaactc ttattttttc 1051921 tatttaatat tttttgagac gaaaatgttt ttttaagctg attttaaaat gtattcaaag 1051981 tcagctctgt ttgatttaat ggattatatt atttggatag cttgttacca tcataatgga 1052041 gatactcctt ataaattgga ggttaaaata atgagtcatt ctcaagaaaa aattgcacta 1052101 attacaggag caagcagtca aggggatatt ggtacggcta tttgtcgtaa gttagcctca 1052161 cagggtatac atatcttctt tactcactgg aattctgata cggcctggat agaagaattt 1052221 caacaagaaa ttttacgtat gggtgtccgc tgtgaggcaa tgaaaattga tttatcagat 1052281 gcacatgctg cattcacaat acatgaaaaa atttcagata aattaggata tccttccatc 1052341 cttattaata atgcagctca ttccgcaagt gataattatg tatcgttaga tgctaaatca 1052401 cttgatgagc attatgcggt taatatgaga tcgaattttc ttctttgtgt tgaattcgcc 1052461 cgtcggttta aaaaatctaa tttaatatca ggaagaatca tcaatatgac atcagggcag 1052521 gatttaggtc ctttgcctgg ggagttagcg tatgcagcaa ctaaaggagc tatttctgca 1052581 tttactaggt cgttatcaca agaacttgca ccattgggca tcactgttaa cgccgtaaac 1052641 ccaggtccaa cagattctac atggatgaca gatgaaataa gaaattttct ttcacctaaa 1052701 tttccaatgg ggcgtattgg cacaccagat gatgcagcac gaatgattgc ctttcttgca 1052761 agtgatgagg ctgaatggat aactggacaa attattcatt cagaaggtgg atttattcgg 1052821 ggctaagcta atgaaacacg gtatacacca atgtatgatg tattcccaaa actaaatcta 1052881 aacttgaagc gaaaataagg tcccttctct ttttagaggg ggaccttatt ttattcatgc 1052941 atgttttgca tccagaaaat ctggcggata aagattaata aaccgttaca tatacttttc 1053001 cgaatactgc agtaccttta aacaaagtaa tcgtggcttt cccttttgat ttagccgtca 1053061 ctaaaccatt ttgatcgact tcagcaactt tttggttatc agtccaataa cgagtagctg 1053121 aattattttt aacagaatag gtttctccaa cttttagagg taaattatag tcttgaatct 1053181 tgataacatg tgtaggtgaa atagaaatgt tctttacttc agtaggtgtg gagtttattt 1053241 catgagctga agctaccccg ctgaccgaca gagctaacgc agaaatcgat aaagcagaaa 1053301 caaccgtttt tttgaaattc attttgaaac actcctttaa agttttttgt cttgcactat 1053361 aacaattcaa taaaagtaat tattttcctt gtaaataaat gttaataata tgtgaacgat 1053421 caattgattt gagctaagaa tattgtgtgc cctgcacaga gtttgtattt atgatggaaa 1053481 attgctgaga gagaatggcc atccttaaaa tgttaatagc acacatttga tgggtattag 1053541 tttgttgagc gtgtggaaat tttgttacct gcactttatc cccgaagata ccaaatcact 1053601 tttcttcatc atgttcttac tttcgtactc atacattaga aaatcttcgt tctaaatagg 1053661 tgaagaattg gagtattttt atgaatttct gctgaatata cattacatag caaactcaaa 1053721 gagtataaaa atcgcttttt tccggaagct tcggtaaaaa acgaaacttt tgtctctatg 1053781 attttgtttt ataatgtaaa cggtttctta tatagtatac ttatactatc aatttgctca 1053841 agtagatact gacaggaagg atagaaaaac agatggaata cataaataca agacaaaaag 1053901 agattttgta tctgttgtta tctgaacctg atgactattt agttgtgcaa gatttcgcag 1053961 atagggtaca gtgttctgaa aaaacaatcc ggaatgattt gaaagtgatc gaggattatc 1054021 tcaatgagca ttctcatgca cagcttattc gaaaaccagg gttgggcgtt tatttacata 1054081 tagaagaaca ggaaaggacc tggctaagcc aacaattaca tactgaacat ttttcttcta 1054141 ggcagcggag cgataaggaa agaatgctgc acattgctta tgacttatta atgaatccga 1054201 agcctgtttc cgcaaaagac attgccgctc ggcattttgt caatcgatct tccattaaaa 1054261 aggatttata cgcagtagaa gagtggctga agcgttttga tctcacactg gtttctaggc 1054321 agcggcttgg attaaaggtt gaagggaacg aaagaaataa aagaaaggca ttggcaagaa 1054381 tatctgattt gattcacaat acagcgttta ccagccaatt tattaaaagt aagtttttac 1054441 attatgaagt agactttgtg acgaaagaaa tcaaatcact acaaaaaaag cattccctct 1054501 atttcacaga cgaaacgttt gaaagtttgt tgctgcatac attgttaatg gtccgccgca 1054561 tcaaaatgaa gcagccgatt tcattgtccc caaaagaaat ggcggcagta aaaaagaaga 1054621 aagaatatca atggacattt gcttgtttac agcggcttga accggttttt gcaattcgct 1054681 tccctgaaga agaagccgtg tacttaacat tacatatatt gggcggtaag gttcgttatc 1054741 cattgcagac agaagagaac cttgaaaatg ctgtgcttcc taaggttgta gggcatttaa 1054801 tcaatcgtgt ttcagagctg aaaatgatgg attttcacaa ggatcaggat ttgatcaatg 1054861 gtttgaacat tcatctcaat actgtgctac aacggctgag ctacgatctt tctgtagcaa 1054921 atcctatgct caatgacatc aaaaagatgt acccttattt gttccacctc atcattgatg 1054981 ttttggaaga catcaatcaa acttttgatc ttcatattcc tgaggaagag gcagcatatt 1055041 tgacattgca ttttcaggca gcgatcgaac ggatgcaggg cagcagcgag acacataaaa 1055101 aggcggttat cgtctgccac atggggattg ggatgtcaca attgctgcgg acaaaaattg 1055161 aacggaaata tcaccaaatc gctgtaatgg cttgtattgc aaaggccgat ttaaaggatt 1055221 atatcaaaaa gcatgaggat attgatcttg tcatatccac cattgcgctg gagaatataa 1055281 cggttcccca tattgttgtg tctccgcttt tagagcctgg cgaagagaag aaattaagtg 1055341 cgtttatacg tcagctgggc gaatcacacc gccaaaaaca aaaaacgttt cagatgctga 1055401 acaatacgac tccttttttg gtttttttgc agcaggaggc ggagcatcgc tacaagttaa 1055461 tcgaacagct ggcgacagct ttgtttgaga aaggctatgt tgataaggac tatgcggttc 1055521 atgcggtgat gagggaaaaa atgtcggcta caaatattgg gtcaggcatt gccattcctc 1055581 atgcaaacgc taaatttatt aaacaatcag caatcgcgat tgccacatta aaggagccgc 1055641 ttgaatgggg aaatgaaaaa gtttcgctcg tttttatgct ggctgtcaaa cacgaggatc 1055701 aaactatgac aaagcagctg tttagcgagc tttcatatct tagcgagcag ccggccttcg 1055761 tccagaagct gacgaaagaa accaatgtca tgacattttt atctcatttg gattattaaa 1055821 agcagggatt attccttgct ttttttgttc atggcagggc ttgagaaata aatttgcgag 1055881 tgaagacgcc tattctccag caatgatcta aataaaataa gagtttaata gttggagaag 1055941 aaatgttaca ctcttttctg tatatggtaa agaatgaaaa aacacgattc ggttggtagt 1056001 ccggatgcat gattgagaat gtcagtaacc ttcccctcct cgggatgtcc atcattcttt 1056061 aatatctttt atgaggaggg aatcgttatg aaattaacga tttactacga tggtcagttt 1056121 tgggtaggcg ttgttgaagt tgtggacaat ggaaagctaa gagcctttcg tcatcttttt 1056181 ggcaaagagc cgagggattc tgaagtatta gagtttgttc ataaccaact tttgaatatg 1056241 atggcccaag ctgagcagga aggagtgcgt ttacaaggca ggcgtcaaaa aaagatcaat 1056301 ccaaaaagat tgcagcgcca ggtttcaaaa gagttgaaaa acgccggagt aacttctaaa 1056361 gctcaagagg cgataaagct agagcttgaa gcaagaaagc aaaagaaaaa acaaataatg 1056421 aaagaacaac gagaacatgt aaaagagcaa aggtatatgc tcaaaaagca aaaagcgaaa 1056481 aagaagcaca gaggtaaata atccaaacaa aagcaggcgc agtgcctgct tttgtaatta 1056541 aggactctac tttgtaacat atatccaatg tttatactcc gctgatttat gattcaatat 1056601 aaaccctaac ttctccaagg ttttttgtga gcctagatta tcatgttcgc atcttgcggt 1056661 gatccgggat actgtttctc ggcttaatgc ccagtttatt agtttttggg cggcttccac 1056721 acaataacct ttgcggcgat gacttttatt tgttgcaaaa ccgatttcaa tcatgccatt 1056781 ttcgtctggg tcacctaaaa atccagttcc cccaacaatt tcataattgt ccttctttac 1056841 aataatccat gaatcaaatc cttttgttcc attgtttttg actaaaatct cgcggaaata 1056901 aggtatcgct tcaaaaaaat cagaatttgg ccattcacca tttgtttcat agcctaattc 1056961 tttgatagcc tgatgatctt gtttagacgc ggcgtcaaga aggggaatat caatcgtttg 1057021 taatcgtaat cgattcgttt caaggagaac catatattta atcctctttt ctttttactg 1057081 ggaataatga taacatataa caattttctc tggtaccttg gcagtagaga aagatgaaaa 1057141 aattgagggg gattgaaaga gtgacaggtg agagtttgcc cagaccaaaa acgggtagga 1057201 aaatgctgat gttaatgtgt ccctacccgt ttttctgttc ctgaatgcag ggtttctgat 1057261 aacatgttgt gctacctttt cgcaatcaaa taaagcgata tggctctttg ggtttgcaca 1057321 ggattatgaa tgataatgac ccattggttt cttcgtcttg gaaagcttgc taccgcatac 1057381 aatggagcag tatcgcgcgg agtgaaccca ccatttatca cgttgatatc tcttccttca 1057441 agatgacaaa ctaagtattc acctggattg atgacctgtt ggttcgtcca tgcgtaagaa 1057501 taaaagccgt ctccaagatc ttcggtggaa gatgggggga caaagccatc tacagtcaat 1057561 gtgatttctc ttcttcgctg tctttctgaa aagtctggac ttctttgagg gttatgagta 1057621 tgtgaaaagt aaggaattaa cgcagggcca taaaagtaat gatacaaagc aaccactcct 1057681 ttattttcca ttcatacaaa ttgtatgtgg gagttatttg ttcattcctg ttttgttcca 1057741 tgtagactaa taatgggcta taggcgtcca aggaaatcaa tttgtccttc cgttgattca 1057801 atgctagtaa ccttgaaaat gcaggttagg atgatagaat ttacatatta ctgcaagaag 1057861 ttagacatac atcattttga tagtgggtga aaacaatggc gaaaaaaatg gcaaaaacaa 1057921 atgcggttcg tctgatagaa cagcagaaca tctcttatga ggtattaggg tataaaacag 1057981 acggccagcc ggtagatggc atctctgttg cggaaaaaat cggttattct ttgaaatatg 1058041 tatataaaac gttggttgca gcagcaggaa caaatcatta ttatgtcttt gttgtacccg 1058101 ttgcagaaga gttagatgta aaaaaggcag caaaggtgac aggggaaaag aaaatagaaa 1058161 tgattgcaat gaaggagctg ttagcggtaa ctggctatct tcgcggcggc tgctcgccaa 1058221 ttggcatgaa aaaattgttc ccgacctata ttgatgcatc tgcagaaacg cttgatttta 1058281 ttattgtcag tgcagggaaa atcggtatgc agctaaagtt ggcgccacaa gatttagcca 1058341 gatcatgtga tgccgcattt gcagaaattg tatagatgca gatatagggg aacgaaaaag 1058401 cttagtcata tcgattaagc tttttccgca tccctttcaa atatgatttc aaaataagca 1058461 gctgccccat acccatctat actgggagcg aaaatctgaa cgaatctcca gcctcttttc 1058521 gcataatcat ggatgatttg ctggtagtct tctttaggcc ttcttctcat cgtactcagc 1058581 tcaactctta cgaattcata ttctttcatc gtttgatccc tcctattaag gtatacgtaa 1058641 aatggagcga gaagttccga aaacctaggt taaggtcgga aagtatattt cactcactaa 1058701 acaaatccat ttatgcctga tgcctgcatg catctgggaa gagttaaggg gctataaaaa 1058761 cgaattttac cgggtcagca gtccaaatga atctcttgct tattgcattt gactgagtat 1058821 ataagtaaaa aaagagcggc cagaacatat aagaaggaga tgatcattaa cgcactcata 1058881 acagggtagt gtttagcgga gtagatgaaa aaatcaagct gtgaaatttg tttggggctg 1058941 ctgacggcat caattccatt aagcagtttt gagagtttag cagtatagtt ccaatcaaat 1059001 cgatctgaaa caagctcgct tccttgatac caattaacag cagctaaaaa cagaaatacc 1059061 ataatagaaa atccaagctg aacaactaaa aatattccct tcacttttgt atgacctcca 1059121 aatctatgaa tatgggaaaa tcaaacaata tattaccacc gtatgggtta ttcttgcaat 1059181 ttcacttcca tacaactcaa acgcaagtct atttttttgt ttgtttttgg cttataatac 1059241 ctgatgatgg aaaaagagtg cgggtttata gattagagaa acaaatgtat ttcttagcat 1059301 tttttatttg tggagagagt atagaagcat tcgattagat ctgctttttc acagaaacgg 1059361 ttttcatctg tttgcctgag ctttacaatt ggctggcaaa aaaacaatga tttctttcaa 1059421 tcaaaacatg caacgatgcg acacatttta tatcttgatg acttatttca ttgcctttaa 1059481 gtcatcctat cgagaaagcg atggtatttt atgaacaaag aaaccctaaa aaacatactc 1059541 atgatttttt caatatgcgc aacactccga gaaaccgatg gtatgcgcat agctgatagc 1059601 tggattttga gtgagattat acgatttttg atttgcatgg ttgtgttttt tgccatgaca 1059661 tttctattag atgctgtttt tccaaacaaa aaagagtcac attaatgtgt ggctcttttt 1059721 gcatcatctg atcagaaaca tcataaatga atcgatcatc atgatgaaga acagcaagca 1059781 aaaataaata agcgagtaga caaacatatc ctttgcccac ttcacgtcat cgtctgtttt 1059841 gaatcctttg atgctttttt tgatccatat gcctccgaga accaaggcgg ctaagaaata 1059901 aaatgggctt atatggccgg tgccgagaga gaaaggaaat aatagcgtga ccggcaccag 1059961 gacggcaata tattgcatca tttttatttt tgttacatga ttgcctttga ctactggcaa 1060021 gagcggaacg ccagcagcgc gatattcctc tttgcgtctt atcccaatcg cccaaaaatg 1060081 cggcggctgc cacagaaaca taatcgtgta caacagcact gctgtcatac tgaagtcacc 1060141 ggttacggca caatacccca tcaatggcgg cgcagctcct gggaagctcc cgacaaatgt 1060201 gctccacaca gacgttcgtt tcacccatac cgtatagatg atcgcataaa aaataaaggc 1060261 ggccagtccg agaaaggccg ttaatggatt gagggaataa agcatggcaa gacctgcgat 1060321 tcctaaaaca gagccatatg ttaagatcat ggctggcggc attttccctg tgaccgaggc 1060381 cctgctgcga gttcgtgcca tttttgcgtc catatgccga tcaaaatagt tgttatagac 1060441 agtgccggaa gccatcacaa acgcggttcc caacattgct gttaccattg tcatcaaaaa 1060501 agccaagccg gttaacgttt tttctgcgct tgcaaacgcg atccaaaacc cgccgaaggc 1060561 tgctatcgag tttgatatga taatgcccgg ctttgcaagt ttgataaaat cgtaaatggt 1060621 tacccggttc gaagctttta tgtattttgt ttcagatatg gctgcagaat ctcttgtatt 1060681 ctccaaaaat agacgcctcc cccaaaactg catgcttttg ttatcgtaac aagaggggga 1060741 cagaatcaca attatttccc atatttgtca tgatattgtc atttttaaaa caaaaaaatg 1060801 gggagctgga ctgcccccat tttgatatgt ggcgactagt aaccgtaacc tcccccatat 1060861 cctccgccat aacctccgcc gtaaccgtac caagggtagt aaggcggtcg cgggcgcggg 1060921 tagtaataag gcgggcgcgg ataaaacggg tagaacggat aatacggtct tggataataa 1060981 taaggcggat aaaatggcgg tctcggacgc ggataataat aaggctgtct ttcatcataa 1061041 ggggtaattt gttcaaatga ctgttcattc aaagggtaat ccaagaggaa aacctcccta 1061101 gcttttttta ttccttttac catattcctg atgcttaagt tgggtgtatg tacattcatg 1061161 aaattcggtt ttttttatga tgaaattcct taaaaaggat tgacatgaac ttctaaatct 1061221 catagtatta caaatgtgaa ataaatgtta ctacaatgtt acaaaaacat ttctaaatag 1061281 atacagttcc aactgatgaa gagtaaatcg aaatggctac gaaagaagga gtttttgttg 1061341 ttggcaaaaa gaatcaaatg gtttcatgta ttaatagcag ttgtatgtgt ggtgggcctt 1061401 atcggctttt tccataatca ttcattgaaa aaagaaacgg tcatgaataa agtaagaact 1061461 gattctcaat atgggaatgt tgagatcgca acgcttgtga atgacgggaa aacttttaat 1061521 tacgcggtaa actatcctgt tttcaaaaat gaaaaaatgg attcggcatt aaaaagattc 1061581 gcagaaaaag aggttcgtca atttcaaaag gaaacaaagg acgttgacca agagcatacg 1061641 acaaaacgca acgaattaaa tgttgattat aaaattgtcc attatgccaa acagacagtg 1061701 gcgattgtat ttaatgaata taaatacatc ggcggggcac acgggcaaac cgtgaaaaaa 1061761 acgtttaact atgattttag taaacaagcg tttctttcca ttgatgatat tttcaaagag 1061821 gacgctgact acttacataa gctttcgtta atcgcttatc acgagctgaa aaagaataag 1061881 gacattgccg cggacgatgc actgttaaag gaagggacgg ctccgaaaaa agaaaatttc 1061941 agccgctttg ccatcaagga ggattatatc gaactttact ttgacacata tcaggttgca 1062001 gcaggctatc ttggagagca atcgattgcc attaagaaaa gtcttttgaa agacattctg 1062061 aaagaacaat atattgataa agcaaaaaat aaaaataaaa tcaaagaaca aaagccgaag 1062121 catgaagtga tttctttacc caaagaggaa acagttgatc caaatcaaaa agtcattgcg 1062181 cttactttcg acgacggccc gaatcctgcg acaacaaatc agattctaga ctccttgaag 1062241 aaatataagg gtcatgccac gttttttgtt ttggggagca gagttcaata ttatccggaa 1062301 acgctaataa gaatgctgaa agaaggaaat gaggttggga accattcatg gagccatccg 1062361 cttctcacaa ggctttcagt gaaagaagcg ttaaagcaga tcaatgatac gcaagacatc 1062421 attgaaaaaa taagcggata tcgtccgacg cttgtaagac ccccatacgg cggcattaat 1062481 gatgaactgc ggagtcaaat gaaaatggat gttgcgttat gggatgttga cccggaagat 1062541 tggaaagacc gtaacaaaaa aacaattgtt gaccgtgtca tgaatcaggc gggagatgga 1062601 agaaccattt tgattcacga tatttaccgc acctctgctg atgcggccga tgaaattata 1062661 aaaaagctca ccgatcaagg ctatcaattg gtgacagttt ctcagcttga agaggttaaa 1062721 aaacaaagag aagcgaaata aattagaaaa ggctgtccgt acggacagcc ttttttctat 1062781 ttaataagag cctgtggtgg cccaaacatt taagtttggt cctgaatact tgccgaaagc 1062841 gtaagaagtc cttggatcta aatcatatac catcggtgta tagcaagact tttggccggc 1062901 caccgctttt ccattgccgc ctgcagaatc acaattatat ctttttccgt ctgtgttccg 1062961 ggtaatctcc gcatttgctt catagccaga cgtcaatgta ttattcatcg tgatttttgc 1063021 ccaagccgtt ttacatgtac tgctgaattt aagctcgact actccgatga cttgattgct 1063081 ggcattcact aagtttgagg atttttttgt agagccgctg gacgcacaat cattgtaata 1063141 agggcttttt ccatcgtagg catgggtttc cgccttggcg ggtgcacctt tgacggcaaa 1063201 aacaaatact actgcgaata acaccaatga agccttcata aacagtcttt tcaatttatg 1063261 acctccttaa tatggcaaac aataaatcat atggaggaac aatcaaaaca tgcatgcttt 1063321 tttgtgaaca ataaaggcgg ccgggaggat ggagttcttg gccgcctctg gtatgaggtt 1063381 atgcttttac atcaatggtt tgtccgagag ttggatgttg aatcatcttt aaggtttgat 1063441 cggcattttg ctgggcggtg tccagccttt ttttcgttaa agcaatattt acattctggg 1063501 caagggatgc ttgatgcatc gcaaccgata aagcaggaat atccatggtt ccacctccta 1063561 tgccttacct atcggcgggt ttgtatgatt ttacagtgaa aaatggctta atttctcttg 1063621 ttgaccctta cgctgcggca tatcgtatgt ttttgacaag gagggaatca ggatgaatct 1063681 agtaatggaa aagacctttg agcaatacga aaagctgttt tcaatggaag aacagaaaag 1063741 agaagatgta tttcggtata cgatgatgag gccgtttgaa aagatgtgga ccgccatcca 1063801 agttccgctg aaagcgaagg agccaaacgg ctatgatgtg atcatggctg cgaaaatgct 1063861 gggctatttg gatgtccgtg atgctgaaag cggccagaaa gcactacaaa tactgaaaga 1063921 atcacatgtt tcagagacag ctgaatctgc acttcggcaa tgcatatttt ttgctgagcg 1063981 cgaacagctg cgggtgaatg caaaggagat caaattcggc ctttatatcg ctgatccaaa 1064041 taagcttcag ctgcaaaaag gctactgcgg gtttggcggg ataccgggct ttattcatgt 1064101 atggattaat ccgaacagtt ataacctgcc aaggattcct tccattattg ctcatgagtt 1064161 tcatcataat gtgcggtttt cgtatataga ttttcatcat ggctctgtaa gtgtcgggga 1064221 ttatcttgtg attgaaggat tggcggaatc attcgccaga gagctgtttg gtacggaacg 1064281 attgggccct tgggtaactc gttttgatca tgaagacttg caatattcca ttgatgtgat 1064341 taatgaggtg ctggatgtga aaggattttc ggaagtcagc cgttatatgt ttggtgatcc 1064401 aattgctaac gaccaaggct ttaagcctgc aggtttatcg gcttttgcgg gttatgcagt 1064461 tggctatcat gccgttcagt catttatgaa tcaacatcat atcacgataa gcgaggccac 1064521 acgtttggat gcgaagacca ttatttctca atgcggtctg ttttctacat gaaaaaagcg 1064581 tcacatacag cggcgctttt tgattcccaa aaccagcagt tctatggcgg cacaggcggc 1064641 aattccgatt gtatatgctt cgatatcgct ccataaaaaa ccgtacccta gtacaagccc 1064701 gccaagagaa gtatctctaa tctggtcgat ccattcggca tgatagagct ggctgaattc 1064761 aatgacaaaa cagaaagaaa gactgataat gcccgttatc attgtcttca gcttccgaaa 1064821 tagaaatccg catcccgtga agatcatggc ggcccacaac gagtctccca gataagtatt 1064881 gagggtatca ggaagaacac tggagaatgc tctggatcca agccccagcc caatgatcag 1064941 tatggtgaaa actgcatata tccaacgatt tcgcttcatt gcgaattgat accccgtctc 1065001 tgcttcatct ccctgtattg taaggaatat agcttttatt tgtccactaa aaaagcggct 1065061 gaatagccgc gtagggtgtt tattttgctt ttaggtttac atggtcggct gtctgatccg 1065121 tgcctattac aaaatggagt tcatagcggc ctgtatcata tacataatcg atttcatcgg 1065181 taaacgggac ggttaacacc cgatttactg gtcctaattg cttctgcagc acttccggcg 1065241 taactccgcc taaattcagc tgccgttcca caccggttcc aaagtagcgg atttctgaaa 1065301 ttgtcatgtc tttatgatag gaaaatccgt agcccggctg tcccatattc cagtgatata 1065361 aatcaaatcg attgtctccc ccgactggtc tttccggttc cccaaacgca gcgtggacat 1065421 ccccttttgt gcttttgtta atggtaaggc cttgcgcctg ctgaggcatt tcccctttat 1065481 aggcggtgtt atagaggttt ttgacaagct cagcggctga ttgattcgtg ttttctgaga 1065541 gtgtgtttgt ttgagctgcg gcctttgccg gtgctgaaaa ggacgcagcc ccaaagccgg 1065601 taaaacagct tgttactgct gctgccgcgg ttatagcaga cattgtcttt ttcatgttaa 1065661 tccctcctaa ttgatctacc attccgtttc cccgtgtttt tgcaacgaaa catgtgagtg 1065721 cgctttgtat gttttattga gttgttgtaa gggaactgaa ataggtaatt cggtatataa 1065781 agcaagaaag gggaatggag atggctggca agaaaacaat cacaataaac ggcgttgaaa 1065841 tggaagcgtc cgaggaacag acggtgctgc agcttttgaa taacagctcg attgaagtgc 1065901 cgcaagtttg ctatcatcca agcttagggc cgattgagac atgtgatacg tgcatcgtca 1065961 gcatcaatgg tgagctgaag aggtcgtgct ccgctgaatt aaaggatggg gatgtcattg 1066021 atacgctctc acctgacgtg aaaaaagcgc aggtcatcgg gatggacaag attttatata 1066081 atcatgagct ttattgtaca gtttgcgatt acaacaatgg gggatgcgaa atacataata 1066141 cggtgaagga aatgaaaatc aatcaccaaa gcattccgtt tgatcacaag ccataccata 1066201 aggatgaatc ccatccgttt tatcggtatg atccagatca atgtatattg tgcggacgct 1066261 gtgttgaggc atgccaagac gttcaggtaa ctgaaacgct gaccattgac tgggagcgga 1066321 aacgcccgcg cgtcatttgg gataacgacg tgccgatcaa tgagtcgtca tgtgtgtcat 1066381 gcggccattg ttcaacggtc tgtccgtgca acgcgatgat ggaaaaagga atggaagggg 1066441 aagccggata tttaacaggc atcaataacg aaacgctgcg accgatgatc gagatcacga 1066501 aaggcgtaga gacaggctac ggctcgattc tcgcgatttc tgatatggaa tcggccatgc 1066561 gtgatgaacg aatcaaaaaa acgaaaaccg tctgcacgta ttgcggcgtc ggctgcagct 1066621 ttgatgtctg gacaaagggc agagacattc tgaaagtaga gccgcaggag gaagcgcctg 1066681 ccaacggcat ttctacttgt gtgaaaggca agttcggctg ggatttcgtt aacagcgaag 1066741 aacgcctgac aaagccgctg atccgtgaag gcgatcattt ccgtgaagca gagtgggagg 1066801 aggcgttatt gctgatcgcc agcaagttca ctgaattaaa agaggcgttt ggcccggatt 1066861 ctctcgcttt tattacatct tctaaatgta caaatgaaga atcctatctt atgcaaaagc 1066921 tggccagagg ggtcattggc acaaataatg tggacaactg ctctcgctat tgccaatctc 1066981 ctgcgactgc cggcctgttc cggacagtcg gctatggcgg tgattcagga tcaattacag 1067041 atatcgcgca agcggacctt gttttgatta tcggttcgaa cacgtctgag tcgcatccag 1067101 tcttatccac tcggattaaa cgggctcata agctgagagg gcagaaagtg atcgtcgcgg 1067161 atatcagaaa gcacgaaatg gcagagcgct cagatttatt tgtccagccg cgtgccggat 1067221 cggatatcgt ctggctgaat gcgatcgcca aatatttaat agaaaacggc aaggccgatg 1067281 aacgattttt gagagaaaga gtgaacggac gggatgaata tgtaaaaagc ctcgcgccgt 1067341 acacacttga atatgctgag gagaaaaccg ggattgatca agaaaccctt atccaaatgg 1067401 cagagatgat cgggcaagct gacagtgtgt gcgcattgtg ggcgatgggc gtgacacagc 1067461 atattggagg aagcgacacg agcacggcga tctctaatct gctgcttgtg acaggaaact 1067521 acggaaaacc gggagcaggt tcttacccat tgcgcggcca taacaacgtg cagggagcaa 1067581 gtgactttgg gagtatgcct gacagactac cgggctatga aaaagtgacg gacgaacaag 1067641 tccgccaaaa atacgagcgt gtgtggggtg tgccgctgcc gaaggagccg ggtatgacca 1067701 accacgaaat gattgaaaaa atccattccg gacagttgaa agcgatgtat gtaaaaggtg 1067761 aagaaatggg ccttgtcgac tccaatatca atcatgtaca cgctgcatat gaaaagcttg 1067821 atttctttgt ggtgcaggac attttccttt cacgtacagc ggagtttgct gatgtggttc 1067881 ttcctgcgag cccgagcctt gaaaaagaag gaacgtttac aaacacagaa cgccggattc 1067941 agcgtttgta tcaggtattt gaaccgctgg gtgaatcaaa gccggattgg cagattatta 1068001 tggaggttgc caataagctt ggcgccggct ggctctatga gcatcctgca gacattatgg 1068061 aggaagcagc caagctgtcg ccgatttatg ccggtgtcac ctatgaacgt cttgagggct 1068121 ataattccct gcaatggcct gtaaacgctg atggaaagga ttcgccttta ctctttacag 1068181 agcgcttccc tttcccagac ggcaaggcca ttctctaccc tgtccagtgg acagagccta 1068241 aggaattcgg tgaggaatat gatatccatg tcaacaatgg gcggctcttg gagcacttcc 1068301 acgaagggaa cctgacttac aaatcaaaag ggatttcgga gaaaacaccg gaagtgttct 1068361 tagaaatttc tcctgagctt gcggcagaac gagggattca ggacggaacc ctcgtcagac 1068421 tcacatcgcc tttcggaaat gtcaaagtga agtgcctgat tactgatcga gtcaaaggga 1068481 aggaagtata tctgccaatg aacgattcag gggaagcggc gatcaacctg ttaacaggca 1068541 gccatgccga taaggatacc gatacgcctg cttacaaaga aacatcggcc aagatggaaa 1068601 ttttgaagca cgacggaatc agcccgctgc ctaagatcaa ccaccgcaac ggcaatccgc 1068661 agccgcaaat cggtgtgcag gttcataaga aatgggcgcg gaaggattat attttccctg 1068721 gtgacgctgt gaaaaggggg atgggccata atggctaaag cgattaaacg aatccaaaaa 1068781 atcgaggtaa cagaagagga tcagcgaaag cgtgatttgc gggaaattga agatgctcta 1068841 attgaccaca aagaagcgat tctcgaaaca ttgcatatgc tgggccatat gaacgagcgc 1068901 ggggtcctgc cgttgctccg cggccttttt ggtcaagggg ataaagttct tgatatcctg 1068961 gtgaaaaagg cagatacaga ggaaacagcc aatacgctga aaaatctgct tcttctgttt 1069021 ggaacactcg gcatgctgga cgtgaagcag ctggagcctc tcattttgaa agtgaatgcg 1069081 ggtgtggcaa gcgctgtaga gcagaaaaac agtgaagaaa agacaggtta ttttgatatt 1069141 atccgctcgc taaaagaccc ggaaatcaac aaatcaatta cactgctctt ttccttttta 1069201 aaaggaatgg gacaagatac aaaggagctg gaacgcacga cgcagcctcc ggaacaccaa 1069261 aaacatcatc aggaaccccg agagaaaaga ggaatgaata agcgagattg acctcccacc 1069321 cgagcggctt cagccagctc gggttttttg atgaaaaggt ctaatggact agtaaaaaat 1069381 attcaaatac taggaagaag taagattgtg atgaatgaga tagaaataat cgttactttc 1069441 ttacctgtta agaaaaggga aaatctgatt ataatagaaa tcgattactt tagatggggg 1069501 aacaatcatg aaaaaagtct tattactatt atttgtcttg acgatcgggt tagcgctttc 1069561 tgcgtgcagc caatcgagcg atgcgtcaga gaaggaaaaa ccgaaagaga aaaaatcgca 1069621 agaagagctt gaaaaggaac ttgataagga attgaaaaaa ggcggtgagc cgaagaccaa 1069681 aaaagatgat caaatacata aaataggaga aacatttaaa gcaggacata cgaattttac 1069741 agtgaataaa gttgatagag tgcaaaaagg tgaatatatg aatgttggcg gagctgtaaa 1069801 tgaggagaca aaaacaataa aagatgatga ggaacggctt attatagaag ttacgatgga 1069861 aaatataggg gaagattcaa taagctacaa ttttatcggg tttgatttaa gagataagaa 1069921 tgatcaatca gtgcggcctg ttttttctat agaagagaag ggcagaatcc ttatgggagg 1069981 aacactagta tcggggaaaa aggttacagg tgtactcagt tatgtcatcc ctaaaggaga 1070041 acagaaacat tacacactgg tatataatcc gtttttagct gatacaaata gcagtaatac 1070101 agaagagaga gtaaaggacg atattgatta cttggtgaag ttagattaga tgctaattta 1070161 cagttgcacg tttttcatct gtggaaaacg tgcatttttt atagcgaaac ttgacttgaa 1070221 aggatgagtg ataaaagtgc aaaccaaatg gctggaacgg gcacagcgga ttcgggcgat 1070281 cgcccaagcg gggcttgctt tttccaagga tgtgtacgac agggagaggt acgaagagct 1070341 aatgaagctt agcgcggaaa tgatggcgga ttactcggag aaggacattg aagttatcac 1070401 tgatttatgg caaggcgaga agggctatcc aacaccgaaa gcggatgttc gcggcgctgt 1070461 attcagagag aatcagattt tgcttgtccg ggagaagcat gatgagctgt ggtcgctgcc 1070521 gggcggattt tgcgagattg gtttatcgcc ggctgaaaac gttgtcaagg aaatcaaaga 1070581 agagtcgggg tacgatacag agccgtctcg attgctggcc gtgctagaca gccataaaca 1070641 ctctcatccc cctcagcctt atcactatta taaaatcttc atcgcatgca gcatgacgga 1070701 cgggcagggg gaaacaggga tcgagacgaa tcatgccgct ttttttccgg aagacagact 1070761 cccgccgctt tctcctaaac gaaacacacc ctcacagctt agcatgctgt ttgacttttt 1070821 gcgccatccg gacaagaaaa cgatatttga ctaaaaaaga aagagcctgt gggctctttc 1070881 ttttttataa tgtaatgtgt ttttcgttgg cgagtttcag aagggtcaaa atagaatcgg 1070941 cttgtttatg gccgagtttt tgctttaatt tgttttcttc aactaatcgg ctgccataaa 1071001 ttttgacgga ggctttgtcg acgacagtat gccagttttc ctgttttttt ccctcaacaa 1071061 gcggtttttc atgtctctca gaaaaagaga acacaaagag tacgaatgca agtgaaagta 1071121 ggattccgac aacttgtttt ttgtaatcag tctgtgctgc cacgttgttc tctccttcac 1071181 cttttacctt ctatttaatc atagaaccaa attattttac ataatgggaa agtcattttt 1071241 ggagttagtg catttggttg aaaacagaga cgttttttga gcggagcggt gcaattgaat 1071301 ccatattgga tttgcgtgct tatgcctaag gtcacgttgt gagccaaaac agcagtgcag 1071361 aatagaaaaa aattgaaaga ttatggtaag atgaacgaaa ttcgaggggg aatatatgat 1071421 gcctgcatcg aacatcgtga tcgcctgcct gctgttatca atttaattat ttgtggtagt 1071481 ccctctcttt ttcgaaagcg ggaggtgaag tggaacatta attgctgaat tctttcaagg 1071541 ggagtgaccg tacatgaatg tgttaaaccg ccggcaagcc ttgcagcgag cgctgctcaa 1071601 tgggaaaaac aaacaggatg cgtatcatcc gtttccatgg tatgaatcga tgagaaagga 1071661 tgcgcctgtt tcctttgatg aagaaaacca agtgtggagc gtttttcttt atgatgatgt 1071721 caaaaaagtt gttggggata aagagttgtt ttccagttgc atgccgcagc agacaagctc 1071781 tattggaaat tccatcatta acatggaccc gccgaagcat acaaaaatcc gttcagtcgt 1071841 gaacaaagcc tttactccgc gcgtgatgaa gcaatgggaa ccgagaattc aagaaatcac 1071901 agatgaactg attcaaaaat ttcaggggcg cagtgagttt gaccttgttc acgatttttc 1071961 atacccgctt ccggttattg tgatatctga gctgctggga gtgccttcag cgcatatgga 1072021 acagtttaaa gcatggtctg atcttctggt cagtacaccg aaggataaaa gtgaagaagc 1072081 tgaaaaagcc tttttggaag aacgagataa gtgtgaggaa gaactggccg cgttttttgc 1072141 cggcatcata gaagaaaagc gaaacaaacc ggaacaggat attatttcta ttttagtgga 1072201 agcggaagaa acaggcgaga agctgtccgg tgaagagctg attccgtttt gcacgctgct 1072261 gctggtggcc ggaaatgaaa ccactacaaa cctgatttca aatgcgatgt acagcatatt 1072321 agaaacgcca ggcgtttacg aggaactgcg cagccatcct gaactgatgc ctcaggcagt 1072381 ggaggaagcc ttgcgtttca gagcgccggc cccggttttg aggcgcattg ccaagcggga 1072441 tacggagatc ggggggcacc tgattaaaga aggtgatatg gttttggcgt ttgtggcatc 1072501 ggcaaatcgt gatgaagcaa agtttgacag accgcacatg tttgatatcc gccgccatcc 1072561 caatccgcat attgcgtttg gccacggcat ccatttttgc cttggggccc cgcttgcccg 1072621 tcttgaagca aatatcgcgt taacgtcttt gatttctgct tttcctcata tggagtgcgt 1072681 cagtatcact ccgattgaaa acagtgtgat atacggatta aagagcttcc gtgtgaaaat 1072741 gtaatagata aggagactgg agattcatga aaaagtacca tatttcgatg atcaatatcc 1072801 cggcgtacgg acatgtcaat cctacgcttg ctttagtaga gaagctttgt gagaaagggc 1072861 accgtgtcac gtacgcgacg actgaggagt ttgcgcccgc tgttcagcaa gccggtggag 1072921 aagcattgat ctatcataca tccttgaata ttgatcctaa gcaaatcagg gagatgatgg 1072981 aaaagaatga cgcgcccctc agccttttga aagaatcact cagcattctg ccgcagcttg 1073041 aggagttata taaggatgat cagcctgatc tgatcatcta tgactttgtt gcgctggctg 1073101 gtaaattgtt tgctgaaaag cttaatgttc cggtcattaa gctctgttcg tcatatgccc 1073161 aaaatgaatc ctttcagtta ggaaatgaag acatgctgaa aaaaataaga gaagcagagg 1073221 ctgaatttaa agcctacttg gagcaagaga agttgccggc tgtttcattt gaacagttag 1073281 ctgtgccgga agcattaaat attgtcttta tgccgaagtc ttttcagatt cagcatgaga 1073341 cgttcgatga ccgtttctgt tttgtcggcc cctctctcgg agaacggaag gaaaaagaaa 1073401 gcctgttgat tgacaaggat gatcgcccgc ttatgctgat ttctttgggt acggcgttta 1073461 acgcatggcc ggaattttac aagatgtgca tcaaggcatt tcgggattct tcatggcaag 1073521 tgatcatgtc ggttgggaaa acgattgatc cagaaagctt ggaggatatt cctgctaact 1073581 ttaccattcg ccaaagtgtg ccgcagcttg aggtgttaga gaaagctgat ttgttcatct 1073641 ctcatggcgg gatgaacagt acgatggaag cgatgaacgc aggtgtgccg cttgtcgtca 1073701 ttccgcaaat gtatgagcag gagctcactg caaatcgggt tgatgaatta ggccttggcg 1073761 tttatttgcc gaaagaggaa gtgactgttt ccagcctgca ggaagcggtt caggctgtat 1073821 ccagtgatca agagctgctc agccgcgtca agaatatgca aaaggatgta aaagaagctg 1073881 gcggagcgga gcgtgcggca gctgagattg aagcgtttat gaaaaaatcc gctgtcccgc 1073941 agtaaaaaca taaaaaccga aatcaatttg atttcggttt tctgtttaaa tatttttttt 1074001 catcccgcat ctccggcatt ctctaagaaa ttttccgcct tttacagagc ttttgaacag 1074061 tgtgtaatca cagttgtcgc agcgcccgct gcgggcatcc ggatattcat tgaattcgta 1074121 aacaatcgat gtatcgtagc cttttgtttc atattcttct tttttggttt ccatgtcgat 1074181 cctccgttac aagacgtgtc tgctgtttat cttacagcaa gcttccggcg tattcaatgg 1074241 attttaggag gttgggttta tcttgatttc tcccttggtt tgcgccaaaa tagctttatt 1074301 aagcttatat acataaaaag cctatgcaaa gaggagagga aacgggtatg ggaaaagggt 1074361 tacttggaaa acgcgtggca atcggtggct cacgaaaaac ggaagaaatt agtacaatca 1074421 ttgaaaaaca gggcggaata cctgtcatcc ggcctctcca aggtacagtt tacttagcag 1074481 agaagcaggt ggagccggat ttgcggacgt ttgcggaaga aaaagctgac tgggtcattt 1074541 tcacgacagg catcgggttg gagactcttg tcgatatggc agagaaaatt ggactgaaag 1074601 atgagtttct gcaggccatt cgccaagcga aagcggcatg ccggggatac aaaacgctgt 1074661 ctgcgctgaa aaagcttgga atcacaccgg aagcttcgga tgaagacggg acaacaagag 1074721 gcttaatccg ttccttggag cctcacgact tttcaggaaa aacagtcatg gtgcagcttc 1074781 atggcgaaaa agcgccggct ctcatggcat ttcttgaaga aaaaggcgcg tctgtcctgc 1074841 cgattctgcc ttatcagcac atcccgccgg aggaggaaac ggtggagcgg ttatgccgag 1074901 agctgatgaa cgatgaggtc gatgccgttt gttttacaac ggccattcag gttcgttccc 1074961 tgtttgattt tgccaagggg cgaggttata tcaatgaagt gaagaaggta ttcgaagaac 1075021 gcgccatcgc agctgctgtc ggaaaagtga ctgctgaagc actgcgggaa gagggcatta 1075081 cgagactgct tgcgccagag attgagcgga tgggtgcgat gattgttgag ctggccaagt 1075141 attatgaaga aaaggaataa caagtacaaa aagccgcttt tccctcggaa agcggctttt 1075201 gtctgtcatt cattttgctt cagctgctga tgaacggtga ataatgatgg gtatgtcagc 1075261 acgcttaaga ttacacaagt cagcgcggct gaggccatcg ttgtaaacac gattaagagt 1075321 tgaaagcgta ctgcctgaat cgggtccgcg ccggctagaa tctggccagt catcatgccg 1075381 ggaagctgga caagacccag tgttttctgg ctttcgagcg tcgggatcat actcattttc 1075441 atcgctgagg taagaatgcg ctgtatggat tgcttcggtg tgccgccaag tgacaatatt 1075501 aattgaattt cttctttgcg aacgccgact tctgagttaa gccggtttag aaacaaactt 1075561 gagagcacca tcgaatttcc gatgaccatc ccgctgatcg gaatgacata tcgtgccgta 1075621 agcggaatga tatgaagaga cagcagaatt ccctgcgtca caatttctac gattgctaac 1075681 gcggcaaaca ccctccaaaa cgaaccgata gtatttttct ttcgcttgat gacattttgc 1075741 gccgccaccg cgagcattaa cagcaccatc agcaggataa aaacagggtg gtctccgcga 1075801 aaaatcagcg acaaaacata accgatgata agcagctgca ccgcggcccg gatggtggcg 1075861 atgatcatgt ctttttctac accggcttta aaggattttg ataaaaacaa ggcgatcaaa 1075921 acaaagatca tcgttaaaga gagagaaagg taatccatta ccgagtgcct cccttcaaaa 1075981 attctttcgc tgcttcatgc tgcggagcgg agaaaaatgt gtcggtttca gcgatttcaa 1076041 gcagccggcc atctgccata aaccaaatgg tatcggctat tcgttttgcc tgctccatat 1076101 tatgagtgac ccacatgact gtccattttt tctcttgatg ctgacgtttg atcagttctt 1076161 caatctcaag agcagagacc gggtccaagg ccgatgtgat ttcgtccaac aatagaatgg 1076221 aggaaggatt tgagagcgtt ctggccagtg acagtctttg ccgctgcccg cccgataagt 1076281 ctctggcgct tctgtctaac aactctggcg gcagccctgc aagcgaagcc agcttttcag 1076341 gagagtacag ctgggattga tgcagccttt gtacaagact taaattgtca cgcactgtcc 1076401 cgtcgagcac gggagccgat tgaaacgcga gggctgccgt tcgcctcagc tcattgacat 1076461 tccattctct gacttccttt ccgtatatgt tgacttcgcc gctgtcaggc gttctcatta 1076521 aattacacat agaaaggagg gtgcttttgc ctgagccgga agggcctaaa acggctacga 1076581 ttgcaccctg ttgaatgtct ccggtgacat cctgcagcac atcataggtt tgtccatctt 1076641 gtttatagct ttttctgact gatctgaagg agatggctgg tatgttttgt gtttgatcgt 1076701 ttgcttccat tacaataatc acctttcaat ataagtaggc tgacattata tttaactata 1076761 acgtgaaaca gattcctttt ggtagcacaa ataaaggaga acaggctttc acccattctc 1076821 ctgcagatgc tacgcagtca gatttgactg tgctttcttt ttcggttttc tcggctgtga 1076881 agcgaaggta tgtaacatca tccccgctat tataatgaac aaaccggcaa atgataatag 1076941 agatgggaaa acgcctgaca gcagaacaat ttcaccaagc agcgcgaaaa tcacttcacc 1077001 ggattgagtg gcttcaacag ctgcgagttt ttgcggattg tctcttacca tatcagtggc 1077061 ccagaaaaat aaaaccgtcg caatgatgcc tgagctgacg gcaacgataa aggattgaac 1077121 ggtttgactt gctgttggaa ggccatctga ccaccagccg taagctgcta atataagcca 1077181 gaatggaagg cttgccaatg tcattccaag cacgcgctga aatgtatcaa gccggcctcc 1077241 gtattcttcg agcattcttc ggtttcctaa cggataggca aaagccgcaa tgacaaccgg 1077301 cagcacactg aaaagcagca tcctcccaga aagcgattct gcatgctgaa gctgaatcag 1077361 agccgctcca atcaggatga tcacagaagt gccaagtgaa accaggggaa tcttttggcg 1077421 aatgagctgc ggaccgcccg gcatatcttg tttgacataa aacaaaggag ataagagcac 1077481 cccggctaca attgtaattt gccaggttcc agctatgagc caccccggac cgtatgcagc 1077541 cgcaaatgta atcggtgcgt aaaaaagcac gaaaccgacg aagctccatt tgatccaata 1077601 aaacggcttt ttcctcattt ctagtaagag aggcgtgaat gtccctctca tgatgacaat 1077661 caaacataaa aatggcacca taaaaataaa gcgcagcgaa gagctccaaa gccagctgcc 1077721 tcctgataac tccatcgctc tgtttaatat aaaggtaacg gcgaaaaaga gtgaagccaa 1077781 tattccgata acgatagctt tcatgatatc cctcattctg gcattatttt tttatactat 1077841 actattcggt atcatgcaga tcaatggaat catgagaaaa acatcatgtt tggcgaaccg 1077901 ctatatgtgg aagacaaaaa agggaggtga aattgatgga aagagagaca cagacatact 1077961 tctttccgga tgacggcagg attccgaatc accctgattt tccgctcgtg gtgtatcaaa 1078021 acgcgcttaa ggacaccgga ctggcagagc ggatcgtcac ccggcatggc tggtcaaaca 1078081 gctggtcagg gagtgttttt ccataccatc attatcacag caatacgcat gaagtcctga 1078141 ttgcccttag gagagaggct gtgattcagt ttgggggaga aaaaggggct gccatccctt 1078201 tcaaatcagg cgacgcagtc gtgattccag ccggagtcgg acataaaaag ctcagctcaa 1078261 gccccgattt tactgtcctt ggcgcctatc ccggtggcgt tcagtacgat atgaagacgg 1078321 ggaagccgaa tgagcgggag gaagcggtca aacagattaa gcaggcggcg ttgccggcga 1078381 atgatccgat cacaggaaaa agagagcctc tattggaaat atgggtaaag tgaaggggag 1078441 aaattgctgg attgtcaata actagtgccg cagaaacgat atgacatgag ctccatataa 1078501 attaatttca taatcgaagc aattcacgtt caaattttgt tcaaaaagtg ttatcatata 1078561 gaaggtaatc gaattggagt tttttgtgtt tgctattttc agagagagta aaggattttg 1078621 acttattcaa ttgtttattt ttagataaaa ataatactga atatggcaag atgaaaaact 1078681 gggtagtaaa catttatttt tgtaaatgat tgtgcatgaa ttcacaatcc ttattcttat 1078741 gccttaaaag cgtgagacag ggagaggcac taccctttcc aaaaaaatca gcaaactgct 1078801 tatagtaaag gagaattgga tatgccagaa acaatcgatc aaacaaatgc gtctgtcagc 1078861 caaagccagc aagatcttat tgatcagcta ttaaagccag aagttcaaga atcattgact 1078921 gttttagttg accagcttcc gaagctgact gagttagtga atattttaac gaagtcttat 1078981 gatttcgctc agtctgtagc gactgacgaa gtgttaaaga gcgacacagt cggtgcgatc 1079041 actgaaattc tcgagcctgt aaaagaaaca gcgaaagaag tagctgcgac tgcgatcgaa 1079101 gcaaaagacc gcgcggaagc aagcaacgaa acaattggac ttttcggcct tcttcgcatg 1079161 ctgaaagatc ctcaagctca aaagctgttc cgttttgcta acagctacct tgaagtcatg 1079221 aacgaacgcg aaaaccaaaa ataatctcag attcaaattg atataaagga cggaggatat 1079281 acgatgtcaa aacatattgt cattctaggc gctggttatg gcggagttct ttctgctcta 1079341 acagttcgca aacattacac aaaagaacaa gcacgcgtga cagtggtaaa caaataccca 1079401 actcaccaaa tcattacgga attacaccgc cttgctgcag gcaacgtgtc tgaaaaagcg 1079461 gttgcaatgc cattagaaaa acttttcaaa ggcaaagaca ttgatcttaa aattgcggaa 1079521 gtaagctctt tctctgttga taaaaaagaa gttgcgcttg ctgacggttc tacattaact 1079581 tacgatgcgc ttgttgtagg tcttggttct gtaacggctt acttcggcat cccaggtctt 1079641 gaagaaaaca gcatggtatt gaaatctgct gccgatgcga acaaagtctt ccaacatgtt 1079701 gaagatcgtg tgcgcgagta ctctaaaacg aaaaacgaag cagatgcaac aatccttatc 1079761 ggcggaggcg gcttaacagg tgttgagctt gttggtgagc ttgctgacat catgccgaac 1079821 cttgcgaaaa aatacggcgt agaccataaa gaaatcaaat tgaaacttgt tgaagcaggt 1079881 ccgaagatcc ttcctgttct tccggatgat cttatcgagc gtgcgactgc aagccttgaa 1079941 aaacgcggcg ttgagttctt aacaggtctt cctgttacaa atgtagaagg aaacgtaatc 1080001 gatctgaaag acggatctaa agttgttgcc aacacatttg tttggactgg cggcgtacaa 1080061 ggtaacccat tagtcggtga atcaggccta gaagtgaacc gcggacgcgc gactgtaaat 1080121 gacttcctgc aatctacatc tcatgaagat gtattcgttg ctggagacag cgcagtttac 1080181 ttcggtccag acggccgtcc atacccgcca actgcacaaa tcgcatggca aatgggtgag 1080241 ctgatcggtt acaacctatt cgcttaccta gaaggcaaaa cgcttgaaac attcaagcca 1080301 gtaaactctg gtacacttgc aagccttgga cgcaaagacg cggttgccat cattggtgct 1080361 aattctacac cgcttaaagg tcttcctgct tccttgatga aagaagcaag taatgtacga 1080421 tatttgacac atattaaagg acttttcagc ctggcttact aatcctttta atgaatctgg 1080481 cattgccaaa agcattcctt tccgagtgct ttctggcaat gtcttttttt atgtttatga 1080541 cagcgttaac atttcatttt caaaaaagag attgatccca aaggaatata aaggtaaaat 1080601 aaaaacaaat caaaatgtta acgttaacat tttgaaatag aatgaaagac ggtgaggaca 1080661 tggaaccctt catgggcaaa aactttttat tgaaaaatga aaccgctgtc agcctctatc 1080721 acaattatgc gaaagacatg ccaattattg attaccactg ccacttaagt ccgaaagaaa 1080781 tctatgaaaa taagacattt caaaacatca cggaagcctg gctgtatggt gaccattata 1080841 aatggcgcat catgagagcc aatggaattg aggagacata cattaccgga gatgcgcctg 1080901 atgaggagaa atttatggct tgggcgaaaa ccgtgccgat ggcgattggc aacccgctct 1080961 acaactggac tcacttagaa ttgcagcgtt tttttggcat ttacgagatt ttaaacgaga 1081021 agtccgggtc ggctatatgg aaacagacaa ataaactgct caaaggggaa ggcttcgggg 1081081 caagggattt aatcgtgaaa tcaaatgtaa aggtcgtgtg caccacagat gaccctgttg 1081141 attctcttga ataccattta ttgttaaaag aagacaaaga ctttcctgtc agtgtgctgc 1081201 ctggatttcg gccggataaa ggacttgaga tcaatcgtga aggctttcct gagtgggtgc 1081261 aggcgcttga agatgccgct gccatatcga ttacaaccta tgatgagttt ttaaaggcgt 1081321 tggaaaaacg agtgcgattc ttccactcag ccggcggcag agtttctgat cacgcgatag 1081381 atacaatggt atttgccgaa acaacaaaag aagaagctgg acggattttt tctgacagat 1081441 tacaaggaac agaggtttct tgtgaagatg agaagaaatt taagacatat acgcttcagt 1081501 ttctttgcgg tttgtatgcg gagctcgatt gggcgatgca gtttcatatc aacgctttaa 1081561 gaaacacgaa tacaaaaatg atgaaaaggc tcggacctga tacagggtat gattcaatga 1081621 acgatgaaga aattgctaag cctttataca agctgctgaa ctcagttgag atgaagaacc 1081681 agctgccgaa aacgatttta tattcactga atccaaatga taactatgtc atcgccagca 1081741 tgatcaacag ttttcaggac ggtattaccc cgggaaaaat acaattcggc acagcctggt 1081801 ggtttaacga tactaaagac ggaatgctcg accaaatgaa agcgttatca aatgttggcc 1081861 ttttcagccg ttttatcggc atgctcaccg attccagaag ctttctttcg tatacgcgcc 1081921 acgaatattt caggcggatc gtctgcaatt tgattggaga atgggtggaa aacggcgaag 1081981 tgccgcgcga tatggagctt ctgggaagca tcgttcaggg gatttgctat gacaatgcga 1082041 aacactactt tcaatttcaa gaagagaaag caaacgtgta acaaagtgtc cgctcagtat 1082101 cgctgagcgg atcactatcc gaaaattctt aagacacaga ggtggaacat gcgaactgaa 1082161 ctggcaaata aggttgtgtc ggtcgaaacg gaaaaaaggc tttcattgaa agagaaaatg 1082221 tcctatggct ttggtgattt tggcaacggt tttatgtttg atctcggcca gatttattta 1082281 ttgaagtatt tcactgatgt agcgggaatc cccgctgcga tggccggcgg cattttttta 1082341 gtcagtaagc tgtttgcagc gataacagat ccaattgtcg gctcatcaat cgattatcgc 1082401 aaaaacatcg gcaaacgggg gaaattcagg ccttatctat taatcggcag catcgtgctt 1082461 gcggtgctta ctgttcttat ttttctgtct cccaatgtat caacgaccgg aaaactgata 1082521 tatgcatatg catcctatat gatttggggc atcggctatt cgtttgtgaa tattccgtac 1082581 ggctcattag gggcagcgat gactcaaaat tctgaggacc ggacctccat ttcgacgttc 1082641 cgccaaatcg gatcacttgg cgccttgttt atcacaagtg tggccgtgat gccgctgctc 1082701 gtcaagtttg ataatccgaa ggtcggctac ccggtggtca tgggcttgtt cgccgcgctc 1082761 ggtgtgtttt ggttttatat ttgctaccgc aactgcaaag agcgcattat catatcggaa 1082821 gcacccaaag aaaaattaac actctcatct gtcgtcaaaa catttattac aaataaaccg 1082881 ctgttaaccc ttgtcctgat gacgattttt tcaatttccg catacaacat taaatccgcc 1082941 atgctcgtct atttcgcaca atataacttg ggcaatgttg aattaatggc ttatatgaac 1083001 ttcatcatta ttggttcttc ctttttgggc gtcgtattcc ttccaaagct cgtcaagatg 1083061 tttggaaaga aacgaacggc aatgatcggc tttggcatca gtgtggccgc ggatctgatc 1083121 aactttatgc ttccatctaa cgtttatgtg tttacaattc tcgccagtat cgcctttatc 1083181 ggaatcagta tcccaaatgg catcacgtgg gctcttgtct ccgatattat cgactatggc 1083241 gaatggaaat ccggtgaacg gaaggaagca acgacatatt cacttttcaa tttctcaaga 1083301 aagcttgctc aatctttgtc tggctttctc tcggggatcg gtttggggat tatcggctat 1083361 gtgccgaatg cagtccagac agcacaggcg ctgattggca tcaaagcgct gcttcttctg 1083421 tatccggcca ttgctttggc attagcgatg ttcattatcg gctttcttta taaactcaca 1083481 gaccagcagc atgctcagat cgttcaggat cttcatcaaa agagctgaca atataatata 1083541 aagaatattt aaaataattt gtaaataaaa tgtgtttgta ggggtttcgc ttggagagtg 1083601 cccaaaaaac tgaaaaggaa ggaggcactt gcttgaaaac gataacaatt gcagctgaag 1083661 aagcaaagga actcgtttgg caaaagctgg acggtgccgg tttgaatgaa cgagatgctg 1083721 aaaaagtggc agatgttctc gtgcacgctg atttgcgcaa tgtacattcg catggcgtgc 1083781 tgcacacaga acactatgtg aacaggcttt tagcgggagg gatcaatcct ggggcacagc 1083841 ctgtttttaa agagacgggg cctgtgaccg gggtgcttga cggagacgat ggtttcggtc 1083901 atgtgaattg cgacatggcg atggaccatg caattgacat ggcgaagaaa aaaggagtcg 1083961 gcatggtcac ggccgtaaac agcagccatt gcggagcgct aagctatttt gtgcaaaaag 1084021 cggctgacga aaagctgatc ggaatggcaa tgacgcatac agacagtatc gttgtcccat 1084081 ttggggggag gactcctatt ttagggacaa atccgattgc ttacggagtt ccggctaagc 1084141 ataaaaaacc gtttatccta gatatggcga catccaaagt ggcttttggg aagattctgc 1084201 aggcccgtga agagggcaaa gaaattcctg aaggatgggg agtcgatgaa aacggagaag 1084261 cagtaactga tcctgacaag gtcgtctcac tttcaacatt cgggggcccg aaaggctatg 1084321 gactatcgat tgtagtggat gtgttttccg gattgctggc gggcgcggct tttggccctc 1084381 atattgccaa aatgtacaac ggccttgatc aaaaaagaaa gctggggcat tacgtttgcg 1084441 cgatcaatcc atcctttttt actgactggg atacgttttt agagcagatg gatgccatga 1084501 ttgatgaact gcagcaatca ccgccggctg ttggattcga aagagtgtat gtgcccggcg 1084561 agatcgagca gctgcatgaa gaaagaaata agaaaaacgg aatttctatc gcccggagcg 1084621 tgtatgaatt cttaaaaagc aggtgagtaa aatgaaagcg gttcaagtgc gaaaagcgta 1084681 tgatctggtg acagcggagg tgaagaagcc agttctttca aaggatgatg aagtgctcgt 1084741 gaaagtcaag cgagtcggca tttgcggttc agacatgcac atttatcatg gaacgaatcc 1084801 gctcgctacc ctcccgagag tcatcggaca cgaggtaacg ggacaagtgg aggcagttgg 1084861 tgcgaatgta cagagcctaa aacccggtga tcatgtggtg attgagccga tttcttattg 1084921 cggatcgtgc tatgcctgcc gcaaagggcg gccgaatgtt tgcgccaagc tttctgtatt 1084981 tggcgtacat gaggacggag gcatgcggga atatattgtg cttccggaaa gacagcttca 1085041 cgcggtctca aaggacttgc cttgggagga agcagtcatg gccgagcctt atacgatagg 1085101 cgcccaggca gtgtggagag gccaggtgga aaaaggtgat accgtcctga tccagggagc 1085161 ggggcccatc gggatctgtg tgttaaaaat ggcaaaactg gcgggcgctg ctgtcatgat 1085221 gactgacttg aacaacgagc ggctggcatt tgcgaaagaa aacggcgccg atgctgttgt 1085281 aaatgtccaa gcagaacatg ttgccgagcg ggtccttgaa tggactggga atgaaggagc 1085341 aaacgtggtc attgatgctg tttgcctgcc ggagactttt gcactttcaa ttgaggctgt 1085401 gtcaccggcg ggacatgtgg ttgtgcttgg atttgatgaa agagcggctc agatttctca 1085461 gctgccaatt acaaaaaaag aagtcacgat aaccggatcc cgattgcaga ccaatcagtt 1085521 tccaaaagtg gtagagcttt tgaatggagg ccggttaatg cataacgggc tggtgaccca 1085581 tacattttca gttgatgacg ttcatcatgc atttcagttt attaaggagc atccagatca 1085641 ggtgcggaaa gccgtcatca cgtttgatta aatgactgaa tccggaggtg cgagcatgaa 1085701 tatgacattc cgatggtatg gacgaggcaa cgatacagtc acacttgaat acgtgaagca 1085761 aattcccggt gtcaaaggca tcgtttgggc tctccatcaa aagcccgtcg gcgacgtgtg 1085821 ggaaaaagaa gaaatcagag ccgaaactga atatattcaa tcctatggtt ttcatgctga 1085881 agttgtagaa agcgtgaatg ttcacgaagc gattaaactt gggaacgaag aacgcggccg 1085941 gtatattgaa aactacaagc aaacgatccg caaccttgcc ggatttggcg tgaaagtgat 1086001 ctgctataat tttatgccgg tttttgattg gacacgcacg gacatgttcc ggccgctaga 1086061 agatggatcg accgctctgt tttttgaaaa ggccaaggtg gaaagccttg atcctcaaga 1086121 gctgattcgg acggtggagg aagcatccga catgacactg ccggggtggg agcccgaaaa 1086181 attggctcgg atcaaagagc tttttgctgc ctacagaacg gtcgatgaag aaaagctatg 1086241 ggacaattta tcattctttt tgcaggaaat tcttcctgtt gctgaggcct atggtgttca 1086301 aatggccatt catccggatg acccgccgtg gccgattttc ggactgccgc gcattatcac 1086361 aggagaggca agctataaga aactgcgggc gatatcagat tcaccgtcta attgtatcac 1086421 cctttgtaca ggttcaatgg gagccaatcc cgctaacgac atggtggaga tcgctaaaac 1086481 gtatgccggc atcgctccat tttcacatat tcgcaatgtg aaaatttatg agaatggcga 1086541 ttttattgaa acatctcatt taacaaagga tggttcgatc aacattcaag gcgtgatgga 1086601 agaactgcat aagcaggatt acgaaggata tgtcagaccg gatcatgggc gccatctttg 1086661 gggcgagcaa tgccgcccgg gatatggctt atacgatcgg gcacttggca tcatgtattt 1086721 gaacgggctg tgggacgctt atgaagcaat ggcaaaaaaa gaggtgggca tatgatcccg 1086781 ctgcatgaga acctggctgg taaaacggct gtcatcactg gcggcagcgg cgtgctttgc 1086841 tctgcgatgg cccgggagct agcccgtcat ggcatgaagg tggcgatttt gaatcggacg 1086901 gctgaaaaag gccaagcggt cgtgaaggag ataacggcgg ctggcggcac agcgtgcgct 1086961 gttgctgcgg atgtgctgga caggatgtca ctggagcggg caaaggaaga catccttggc 1087021 caatttggcg ctgttgatct gttaattaac ggggctggcg gcaatcatcc tgacgcgata 1087081 accgatgtgg agacatatga agaagcggga gaaggccaat ccttttttga tatggatgag 1087141 aggggctttc taactgtatt ctccaccaac ttcaccggtg cgtttctggc ctcgcaagtg 1087201 tttggtaaag aactgctgaa ggcggattca cccgcgatca tcaacctttc ttccatgagt 1087261 gcttattcac ctatgacgaa ggttccggca tacagtgctg cgaaagcatc catcaataat 1087321 tttacgatgt ggatggctgt tcattttgcc gaaaccgggc tgcgggtcaa tgcgattgcc 1087381 ccaggcttct ttctgacaaa acaaaatcat gatctgctga tcaaccaaga cggaacgttc 1087441 accagccgat ctcacaaaat tattgcggga acaccgatga agcgcttcgg aaaaccggag 1087501 gatttgctcg gtacgctcct ttggctggcg gatgaatcct attccggttt tgtcactggg 1087561 atcaccgttc ctgtcgatgg aggatttatg gcttattcag gtgtgtaacg aaagcggtgc 1087621 aacagaaact gaaccaacat aggggtgagg ttgagatgtt ttcaaaagat aagcttcccg 1087681 ttatcctttt tttgttcctg gcaggggtga ttaattacct ggatcgctcg gcgctttcca 1087741 ttgcagctcc ttttattcag gatgatctca cattgtctgc cacacaaatg ggcttgattt 1087801 tcagcagttt ttcgataggt tatgccattt ttaattttct tgggggcgtg gcatccgacc 1087861 gctatggggc aaagctgacc ttgtttgtcg cgatggttgt ttggtcgctg tttagcggag 1087921 cagtcgccct cgcttttggc tttgtcagcc tgctgattat acgcattctc ttcggaatgg 1087981 gagaaggccc gctttcggcg accatcaaca agatggtgaa caactggttc ccgccgaccc 1088041 agcgggcgtc cgttatcggt gtaaccaaca gcggcacgcc cctcggggga gccatttccg 1088101 gcccgatagt cggcatgatc gcagtggcgt tcagctggaa ggtatccttc gttctcatta 1088161 tgattattgg attgatatgg gcagtgctct ggttcaagtt tgtcaaagaa aagccgcaag 1088221 agacgatcaa ggaagcaccg gcaataaaag cagaaacgtc tcccggagaa aaaattccgc 1088281 tcacctttta cctgaagcaa aaaacagtcc tgttcacggc gttcgctttt ttcgcttaca 1088341 actacatcct cttcttcttt ttgacatggt ttccgagcta tcttgtcgac gagcggggat 1088401 taagtgttga atcgatgagt gtcatcacgg tcataccgtg gattttagga tttatcgggc 1088461 tggctgcggg gggatttgtt tctgactatg tgtacaaaaa aacggcccga aaaggtgtgc 1088521 tgttctcgcg caaggttgtg cttgtcacgt gtttgttttc atcagctgtc ctgattggtt 1088581 ttgccgggct tgtggcaacg actgcggggg ctgtcactct tgtcgctctg tcagtgttct 1088641 ttctttattt gaccggtgct atctattggg ctgtcattca agatgtggtt gatcaaaaca 1088701 atgtcggttc tgttggcggc ttcatgcatt tcctcgccaa cacggcagga attatcggcc 1088761 cggctttaac cggatttatt gttgaccaaa caggcacgtt ttctggagca tttttgcttg 1088821 ccggtgggct ggctgtcttc gcttcacttg ctgtgattcg ttttgtccgt ccaatcattg 1088881 gtaagccagc gggaacagaa gctgagaatc ctgtgtctta ttaatctgga aatatagtgg 1088941 gagaggcggt atgtttgatg atacaatata cagtaaataa tcgcagccgg tatgataagg 1089001 aagggaatta gatggtaacc ataaaagata tcgcaaaact cgcaaacgta tcccacacta 1089061 ctgtttccag agcactcaac aacagccctt acatcaaaga acatacgaag aaaaaaatat 1089121 tagagctagc agagcagctc aactatacac caaatgtaaa tgcgaaaagt ctggcgatgc 1089181 aaaagtcgca tacgatcggg ctattcttta caagcattac aaacggaacc tcacacagct 1089241 tctttgcaga cactatcaaa ggcgtcaatc aagccataag tgaggattac aatctgtatg 1089301 tgcgcggcat tgatgatctg aaaaactatg actccgttac accgatgaga tatgacggca 1089361 tcattttaat gagccaaagt gacattgata attcttttat ttaccatatt cgcgaaaaaa 1089421 acattccgct tgtcgtgctg aatcgtgata ttgatgatcg taccatcacg aatattttgt 1089481 ccaatgacaa ggaaggctct caagaagctg tagaatactt cattcagtcc ggacatcaag 1089541 acatcgccat catcgagggg atcgaaggct ttaaatcctc ccagcagcga aaggaagggt 1089601 acttatccgc actgattcaa catcatattc cgatcaagca tgaatacagt gtcaaaggac 1089661 agtacgatat ggaaagcggc tttcaagcga tggagcggct gctggcactg ccgaatcctc 1089721 caaccgctgt tttttgttcg aatgatgaca tggcaatcgg agcgatgaat gcgatattcg 1089781 caaagggcct gcgcgttcct gatgatattt cggtgatcgg gtttgatgat attgggtttt 1089841 cacagtacat cacgccaagg ctttcaacag taaagcgccc agtggagaaa ataagcgtgc 1089901 tcggtgcgca aaaactcttg tcgctgatca gcgagcccga aacaaaagca gaaaaaatct 1089961 tggaaaacac agaatttatg gtgcgtgatt cagtcagacg attgacgacg tgatgtcccg 1090021 tttttcagcg ggcattcttt atacagaaaa atgttaacgt gtgcataaag tgagagggag 1090081 gcaataaggg tgcagaagct gaataaaaat gtgtacgatc actatactca gtatccagaa 1090141 aaaattctcc aattcggaga aggaaacttt cttcggggat ttatcgattg gcagattgat 1090201 caattgaatc aacacactga ttttaatggg agcgtggcag ttgtccagcc aagaggctca 1090261 gaaaaaatca aacgattaaa tgagcaagat ggattatata cacttttttt acaaggaatg 1090321 aaagacggag aagcggtaaa cgagcatatg attatcaact caatcagccg gggaattgac 1090381 ctgttttctg attatgaagc atacaaagaa ttggcatcaa gcgaaaggct tcggtttatt 1090441 atctccaaca ccactgaggc tgggattgta tgtgatgaaa aagatcgttt agaggatagg 1090501 ccgcaaaaaa cattccctgg gaaattaact gcatttcttt actttcgcta tcaggctttt 1090561 aaaggagatc agacaaaagg gtgtgtcctg atcccatgtg aactgatcga gaataacggt 1090621 gaaaagctga gggaaacggt tcttcattat gcacatctgt ggaagctgga ggaaggattt 1090681 acacagtgga ttcatgaggc caatacattt tgtaatagtt tagtagaccg gattgttccg 1090741 ggttttcccg tcgacagcat tgatgagatc acggcagatc ttggctatca ggatgatttg 1090801 atagttgtgg gagagcaata ttatttgtgg gttatcgagg ggcctgattg gattggaaaa 1090861 gaacttccct ttgcggctgc agggctgcat acaaagatcg tcagcgacct caccccatac 1090921 cggactaaaa aagtaagaat tttaaatggc gctcatacag caatgacgcc agtggcttta 1090981 ttatacggct tgaagactgt tagggatgca gtcgagcatc cggaagtggg gcgatttata 1091041 agagagctga ttgatgacga aattcttcct gttttaaaaa tggaaggtct ttctcagtat 1091101 gctgacgatg tgctgaaccg ttttaaaaac ccgtatatta agcattacct ggaaagcatt 1091161 gcattgaacg ccatttccaa attcaaaacg agaaacctgc cgactcttaa ggaatatgct 1091221 gaacaaaagg gacagcttcc tgaacgcttg gtgttttctt tcagcgctct tctgtatttt 1091281 tatcatgata acgagacatt gcaggatgat ccggcagttc ttcaattttt caaagaggtt 1091341 tggtgtcagg aggatggcga catgcttcgg attgcatcaa gagtgttagg cgaacagcgg 1091401 ctgtgggggg cagatctcaa tgagataccg aagctgactg atagagtcgc tgtttacttg 1091461 aatcatattc atgagctggg catgcagagg gctcttgaac aatactgcat acaaggggga 1091521 gaggtacgtt gaagtcgttt ataaagattc ataagcaaga taatgtcctt cttgctctgc 1091581 gggatattca aaagggagag aggctgcatg cttacggcgt gtcgattgaa gtaaaggatg 1091641 atataaaaag aggccataag attgcattgc agtctatcaa agaaaacgac agcatcgtca 1091701 agtacgggtt tccaatcggt catgcatcac aagatatctc gatcggagag catattcatg 1091761 tccataatac gaaaacaaac ctgtctgata tccaattata cagctataca ccgagatttg 1091821 atgaaaatcc gtattctaat gagaaccgga cgtttaaagg ttttagaaga gaaaacggag 1091881 atgcgggtgt acggaatgaa ttgtggattg tcccaactgt cggctgtgtc aatggaatag 1091941 cagaaaaaat gctgcagcgt tttgtcagag aaacagggga tatcgctcca tttgataacg 1092001 tactggtgtt aaagcatcaa tacggatgct cgcagcttgg cgacgatcat gaaaatacga 1092061 agcagatcct gctgaatgcc attcgccatc caaatgccgg cggcgtcttg gtgttagggc 1092121 ttggctgtga aaacaatgag ctggcaagaa tgaaggaagc actgcaagat gtgaacttga 1092181 agcgggtgaa gtttctggaa tcccagtcgg tgaccgacga aatggaggca ggcgttgctt 1092241 tgctgaagga aattcatgaa gcggccaaag gagataagag agaagacatt ccgctgtctg 1092301 aactgaagat cgggctgaaa tgcggaggtt cggacggttt ttccggcata accgcaaacc 1092361 cgctgcttgg acgtttttca gattatctca ttgcacaggg agggagtact gtgctgacgg 1092421 aagtaccgga aatgttcggc gcagaaacca tcctgatgca gcgggctgcc aatgaagaag 1092481 tgtttcataa gatagtcgat ttaatcaatg atttcaaaca atactttatt aaacatgatc 1092541 agccggtgta cgaaaatcct tcaccgggca acaaagcggg cggcatttct acacttgagg 1092601 ataaatcgct gggctgtacg caaaaagcgg ggatttctcc tgtcacggat gtcttgaaat 1092661 acggtgaagt actcaagaca aaagggctga ctcttttgag cgcaccgggc aatgatttga 1092721 tcgcctcctc cgcattggcg gctgccggct gccaaattgt cctctttaca acgggaagag 1092781 gcacgccgtt tggcaccttt gtcccgacgg tgaaagtagc gacaaacacc gagctgtatg 1092841 aggcgaagcc gcattggatt gattttaacg caggcctttt agcagaggat gatgttcatg 1092901 aggaatatgt gctgcgtgag tttatccact atatgattga ggtggcaagc ggccagcttg 1092961 tgaaccatga aaaaaatgat ttcaaagaac tcgccatttt taaatcgggt gtgacgttat 1093021 aataagaaaa ggctatcctt caagcggata gccttcttca ttaaatcaat tttaaaccgc 1093081 tgactaaaat aatggaagcc ataataaatt gcagtggacg cggggagaat cgaggcgaaa 1093141 gatggctccc gatcagtacg ccgggaattg aaccgaggag cagattagct gccagcatgt 1093201 aatccacgct tccgaagctt gcgttcaaaa tgcctgctgc cgtaacaaga agaaaagcat 1093261 gcgcgatatc ggttccgaca atctgtgacg ctttcatgtt aaataagtaa atcatggcga 1093321 ttgcaaataa tgagccggac ccgattgatg ttaatccgac gataaaccca aacacaacac 1093381 caataagaat tgtcagcgcc ctcttatttt caagcggcat cagctgccag cggttggggc 1093441 gaagttttct atccaaaaac aaacgaacga tgattgaaat ggcaaccagc gttaacacat 1093501 atcctagagc gtgcttaata atttcttcct gatgctggtg aaaggcgggg aacaaatgca 1093561 atatgccaat ggctagcgaa gcactcggaa taccgccgat ggctaagtat tttaccaatt 1093621 taaagttaat cgttttctgc cgccaatggg aggcaacgcc aaacagcttt gtgatcgagt 1093681 tatatacaag atccgtaccg accgcgatgg aaggattaat tccaagcaca attaaaaggg 1093741 gagttaataa ggccgctcca cccactcccg tcaatccgac taaggctccg acaaacaaac 1093801 ccatcaatat gatgcttaca ctcatgataa aggcctcctg aaaacccgac tagaattcac 1093861 ccgaatctta ttcgcgttgg tcaagtatta attgtaagtg ctccatcggc tgctgaaaaa 1093921 cccgagctct atccgctccc tgatggtatc attcaattga caacacctta tacatcagga 1093981 gaacacgtct ttcaggtgca acgagcactt gcggctctgt atttttaccc tgataaaggc 1094041 gctgttaaca acggaattga cggcgtttac ggaccgaaaa cagctgacgc agttgcccgt 1094101 tttcagtctg ttaacggtct aactgctgac ggtatctacg ggcctgcgac gaaagagaag 1094161 atcgcagcgc aattaagctg atcaaagacc ataaaaatcc cggagccgct ccgggattta 1094221 ttttttcttc ttcaactttt ttataattcc agcactgcgc tccctcaccc gaagcgagta 1094281 cccggaaagc ccaaaccttc cgtaatcaac aaacttcaca cgcctcacca attttttcac 1094341 tgtatcacct gacattatcc tctgtttgta tttattatat gtcacccttt aagaaaagga 1094401 ataaggacaa gagctgtttt cccttgtcct tttagtgtga tcatgctttt tttcgtttat 1094461 actcgtcaat cagccgttcg ttttctttga agattcttgc tgtatgcgga ctgacttgat 1094521 agcttgcgac actggtggtt gaacgttttt tcaggatttt aaacggcttc gccgctctgg 1094581 gctcgcatct gttttgaaac gcacgttcca ttatccttca ccttcctcct caattggcag 1094641 caccaaatca tatatgctcg ttaatgacgt aaatagcaaa taatcaaatt ccgtgacaat 1094701 gctgtcagac gtcagcttga tgacatagtt ctgtgtctcg atggtaaaag ggatgagaac 1094761 cacttttccg tattggtcgt aataaacatc ctttcgatcg agccgtgttt gtacatctgc 1094821 cggatcatcc atatgctcgg ttaaccggtc tttatcagcc tgtgtcgaat agtggcaaag 1094881 agaagccgtt aagttcattt tatcagcata ggttttcagc agcttatcaa taccttcagc 1094941 ataagcatct atacttccat aataaacatg gatcggttcg tttttcaata ggtattggta 1095001 tgttttcagc cgattgagat acatgtggag catttcgttg ttttcttcaa gaatttctct 1095061 tgtgtctgtt tcaagctcgc tgccggccag ttttttgaca tatgcactta agaagataaa 1095121 agcatcaatc aaagcaaaac tgactgcgac aatgagatac cgttcccagt gggtaaatag 1095181 ggaagtgggc tcatatgtcc agtataccat agcgcccaga acaaacagca aataccaagt 1095241 tttccgaatg gcggacattt tttctttgac cttcgcttcg aaacgccacg tggcatacac 1095301 gtataacccc agtccggcca cgatgcacca gaccatgatc tgaaagaata aaaccatatt 1095361 cgaatccctc acatctgaaa taggttctgc ttattgtatt cgagagatcc ggatggtttt 1095421 cctgttccat caaaaaaacc gctcctttga cagaagcggt gtgacattaa aatatcatat 1095481 ttaaaataaa gtaggcgatg gcaccaagtg tcgctgaaat cggaagcgtg atgacccatg 1095541 taatgagcat tcgcttggcc gtaccccagt ttacgccttt tacgcggtgg gacgcaccga 1095601 cgccaagaat tgatgaagaa atgacgtggg ttgtactgac cggcaaatga ataaacgtgg 1095661 cgccgaaaat aatggctgct ccggttaagt cagcggaaac accgtttacc ggacggattt 1095721 tcatgatctt tccgccaacg gttttgatga ttttccagcc gccgattgat gttccgagac 1095781 ccatggctgt cgcgcaggcg aattgcaccc aggtaggaat atcattagca gaagtatgta 1095841 aattcgctgt gatgagagcc attgtgataa ttcccattgc tttttgcgca tcgtttgttc 1095901 cgtgtgtata cgattgcagg gcagctgtta caatctgcac tctgcggaat tgcttattcg 1095961 ttttcgccaa gttgctgtct ttgaaaatca gcttaacgat gctataaaga ataaaaccaa 1096021 ggacaaaggc aataattggt gatagaatca gtgcttcaat gattttaatg aagcccttat 1096081 agtttaacgc tgcaaatccg gctgccgcaa tggctgcacc ggcaatagcg ccgatgatgg 1096141 catgggatga gctgcttggg ataccgtagt accatgtgat aaggttccag gcaattgcag 1096201 cgagtagcgc agccaaaatg acaacagagc cattttccag cgtataagga tctacgatgt 1096261 ctttcgtaat ggttttggca acacctgtaa acgtcattgc tccgacaaag ttcatcacag 1096321 cagccaatat aatggcatgg cgcggtttta acgcttttgt tgataccgaa gtcgcaattg 1096381 cgtttgccgt atcatgaaac ccgttgatga aatcaaacgc cagagcacaa atgactatta 1096441 gtatcgttaa tattaataga atatccattt ttacccctcg ttacgcgttt ttcataatga 1096501 tggtttcaag attattggca acactttgac aagagtcggc gatttcttca agcgtttcgt 1096561 atatttcacg atattgaatg actttgattg gatctgtttc atttccgaaa agattcttta 1096621 atgattttct gtgcaagttg tcacaactgt gctcatactc tttaattttg attgcgtgag 1096681 gctgaatatc ctttaagcga ttttctgcca gcagctcgat cgtaatcaaa atctctttcg 1096741 cacattctct gatatatccg ctgaatttat caatatgctc gtctgatgaa gtaattgaga 1096801 aaatctccat catggcagag aaatgttcga ttccgtcaag cacatcatcc aagctgtttg 1096861 tcagctgaag gatatcttcg cgctcaatag gagtgatgaa cgctttgtta agctctttaa 1096921 tcatgacatg aacatgattg tcaccttttg tttcatattc ctttaacgta tctgcaaatt 1096981 ctttaagagt cgtttggtta gtgaccttaa aattcacaaa atattctgca gtttcgtcta 1097041 tgttctttgc aatttctgtt aaaaggagtg agaacttatc tttttttctt cttatcatta 1097101 aaaaccctcc atagtttgaa tgaacaatgc acacatcaaa ttattatata gccttttgtc 1097161 gaaaaaaaac aggtaaagtc gaaaaaaacg tatcttgact tttttgataa atcgtgtctc 1097221 cttattttga cctacttcgc tttaaaaaaa cgacccaagt ttgcaaaaac tttctgctta 1097281 acgtaaaaag tatatcaaaa gttgtgtttt tcctgtcaac ttttatcttc tgtttcacca 1097341 aaaaacggtt ccctaaacaa gggaaccgtt ttatcagctt gcttttcgtt ttttcatccc 1097401 gtaataaaca ggcagtccgg caaggccgat gaggatggat aatccgcagc tcattgtatc 1097461 tgtaatgagt gtgctgccta acacaaagaa ggagcccgcg attgccagaa ttggcataaa 1097521 tggataaagc ggaacactgt aggcgcgctt ttctcccttt gctcgcttgc ggagaataaa 1097581 cactgcaaaa aaggccatca cataaaaaat gtagatcatg aaaatggaga tttctgagag 1097641 cttatcaggg ttgctgatca gcatcataat caaagccaaa gcaatttgaa aagaaatcgc 1097701 aatccatggt gtgcggaacg acgggtgtac atgtgacagt ttttcagcaa atggaagctg 1097761 tttgcgttcc gccattgcaa atgaaacacg cgggaaagaa agcacctttc catttaagca 1097821 cccaaagatg ctgacgataa tccctacact gatcagcttt ccgccaattg aaccgaacag 1097881 catggttgca gcggtgcttg tcgcattttc accaagcgtg acaatttcgt tcgctgacag 1097941 gatgtgaagc aatgcaaaat taatgaaaat atagatcgcc gttacaatta ataatccgcc 1098001 cgtcatagcg cgtggcagca gcttttcggg atttttcatt tctccgccga gagcggcaag 1098061 gagaatccat ccgtcataag caaacaacgt agctaaaata gccgccccga agttcatatc 1098121 agaaatgctt tcgtttactg ctgtgaagat gtgctgatcg cctttccaaa ggccaaagac 1098181 gatgatgcag gcaatcggaa tcagttttcc gatcgttgtc agcgtttgga caaaaccgcc 1098241 gtattttgta ccgataatat taatgacgca taaaaagaga actgctataa ttccaatgac 1098301 ttttgatagt ccagatcccc agccgaaaag attcgccatt aaagatccaa aatataaacc 1098361 cagcgcgcca ataatcgccg ggccgtaaat gataatctgc acccagccgc acaaaaatcc 1098421 ccaaaactcg ccgtacactt cttcaaggta cgtataaagc ccgccggttt ttggaatctg 1098481 cgttccgatt tccgcgattg tcaaaccgcc cgccagtgtt aaaataccgc ctaacagcca 1098541 ggcgaaaagc gccatttttg aatcacctga ataagcaagc acagcgccgg gcttcataaa 1098601 aacaccagaa ccgataatgg ttccgatgac aagagtaagg gcaaacaaga ggcctatctc 1098661 ttttttcaaa ccgttgtctt cagtatgcat gtccttaacc tcctatgatg ttgaagcttc 1098721 atgttgaaga atctattttt tcatattgta aaccctattt tagaaaagtg aaataaaata 1098781 aattttctga ttttcgaaat ttgctttgtg tacagcagat aaaactgtag aaatacctgt 1098841 tttaatggtc tataaacgaa taaaattcat aatttttatt tacaaagttc gtgttttatg 1098901 tattaggatt ttagccggta cagaggggag atgagaattc agaaaatgaa cgaaccttcg 1098961 gtgaagctga tatgttgact ttctcatgcg aataaaatac tttgttatta gaacaataaa 1099021 tatacaatta tgatatgata tctcgaaatc gagataaaat aacctggagg gacagcatat 1099081 gaaagttaac ggcattcacc acgtatcggc attaacggcc gacgcacaaa aaaacttgga 1099141 tttctataag aaagtattag gattaaagct cgtcaaaaaa tccgtcaatc aggatgaacc 1099201 gacaatgtac catctgttct acggagatga agtggcaaac ccgggaactg agctgacgtt 1099261 tttcgagatt ccccgcattg caccgtttca tgcgggaaca aacagtattt cttctattgg 1099321 attgcgcgtt ccaggcacag aagccctgca ttactggaaa gaacgttttg aagagcagca 1099381 agtaacgcac agcggcatct ccaaaagagc cggacgtgac atattggcat ttcaagatca 1099441 tgaggggcag cgacttgtgc tgactgctga tgaggaagga aaaggatatg gcctgcctgt 1099501 taaacagagc ggcattccgg aagaattttc gtttcgcggg ttagggccgg ttgaactgac 1099561 tgtgccatat gctgaaccaa ctttacacgt attgacgaat attcttggat ttacagaaat 1099621 cagccgtgaa ccagtcgaag ggcaaggaac cgccgttatt ctggaatcag gagaaggcgg 1099681 tgctgcaacg gaaatccatt taatagaaag aaacgatctt ccgcgagagc gtcaaggcaa 1099741 agggagtgtt caccacgtcg catttcgggt aagagatgaa gaagaacttg ccgggtggca 1099801 ccggatcatc agccgcgaag gctttagcaa ttcaggcata gttgagcgct actatttcaa 1099861 ggcgctgtat ttcagagaac cgaacggcat tttgttcgag ttatcaacag acggaccggg 1099921 ctttatggta gatgaaaatc ttgatgagct tggccaaacg attgctcttc cgccatatct 1099981 agagcatcga agagcagaaa ttgaagcaaa attgaaaccg atccaataaa ttgtgattct 1100041 tttgccttcc ggcgccgccg gagggctttt tttattacca taattaattt tgacctaaac 1100101 agcatgcctt attagggagg aaatatcaga tgctgattgg gagaaatggc ttaaaaccct 1100161 ttgcaaatat gggtgattgg tatggaatgg cctcggcaaa aatattgtct ttgtttatta 1100221 atagtttatt catatttgct tgttacacta tttcaaagtt agacaaaaag gagtgaaaaa 1100281 taagtggaaa agaaaaaacg cgagctggat atcgtcctcc tcctcatttt gctcgcatct 1100341 gcattcttaa atatctataa catttggaag gacgacacgg tgaatcctta ttacaccgcg 1100401 gcagttacaa gtatgatgca aagctttcat aatttctttt atgcttcgtt cgatgctgcc 1100461 ggctttataa cagtagataa accgcctgtt acataccaaa tccaaacgat cagcgcactg 1100521 atattcggta tgcacggctg gagcgtcatc ctgcctcagg cacttgctgg tgtaggttct 1100581 gtccttctta tgtacttgct gataaagccg acatttggaa aaacggcggc gcgtattgcc 1100641 tcatttgtta tggcatgtac gccgatagct gtagctgtag cacgtacaaa caatgttgat 1100701 gcattactgg tatttttctt attgcttgct acatggcttc tctttaaagc gatcagaaaa 1100761 ggaaagctga tctggctgtt agcagcattt ttcgttgttg gagtaggttt taatacaaaa 1100821 atgctgcagg cttacatgat tttaccggct ttcttattgt tctatctgat tgcggcaaac 1100881 gccacaatca agaaaaaaat cgtttcattg gtaagtgcgt tagccgtatt agcagccgtt 1100941 tcgttatcgt ggccgctcat tgttgacaat atccctgcaa gcaagcggcc ttatatcgga 1101001 agcagccaaa ccaactctgt tttggaattg gctttcggct ataacggaat ccagcggctg 1101061 acaggccaaa attcaggcgg cggccagggt gcgccaaaca aagacgcttc aaaagaaatg 1101121 tcttcttctg ataacactca agcaccgcct aatcagtcat caagcaacag ctcatcaagc 1101181 gatggtaaat cctcaaatgg caatatggcg gcgcctccat ccaatggcca aatgccaagc 1101241 ggcggtcaag gaggccctcc aagcggcgga gatggcggcc aaggcggacc cggcggagac 1101301 ggagggaaag gcggtacagg aaccggttcg aaaatgcaat caggttcagg gatgtttgga 1101361 acgggaacac ctggtccact gcggcttttc caacaagagt tatctgatca aatcagctgg 1101421 cttctgccat ttgcgatatt tggaatcgca ggcttactga tcgctggcgc aagagaaaga 1101481 agaagattat ctgtagagca gaaggaaacg gtgttctggg ttgcgtggct tgtaccgatt 1101541 gccggattct tcagtgtcgc agaatttttc catcattatt atctcatcat gctggcaccg 1101601 ccgattgcgg ctcttgtcgg tgcggggtgg gtcgctcttg ttcatctgta ccgcaatcag 1101661 acaggctgga aagcatggct tttgccggga gcaattattg cgacaactgg atttgaattg 1101721 tttattctca gaaactacaa cgatcaaatc ggtgttggat ggagtatcgg ggtaggtgtt 1101781 atcggcgtgt tgtcagcgat tgctttgctg ctgtttaaac agcgccaaaa accgttcagt 1101841 tattatgttt cacttgcagc tctcctcgca ttgctggtga tgccgatgta ttgggcaagt 1101901 acaccgcttc tgtacggagg caacagctca ctgcctgaaa caggccctca actcgcatca 1101961 atgagcggaa aaggcatggg aatgtctgat gcgactgtaa atgaaaaact gatcaaatat 1102021 ctagaggaga ataactccgg agctgaatac ctattcgcca caaccgattc gaacacagcg 1102081 gcaccatata tcattaaaac gaaaaaagct gtcatggcta ttggtggata cagcggttct 1102141 gacccggcaa tcacactgac tcaattcaaa aaacttgtaa aagaaggaaa agtgaaatac 1102201 ttcttggctt ctggaatggg aagaggcgga aacaatgaca ttgttgaatg ggttgagaaa 1102261 aatggaaaag aagtagcatc agaaaaatgg caatcaagtt ctgatcaaaa aacagaaaat 1102321 actgattcag ctgatacatc aagcagcaag gcttcaggtg aaaacggcaa aatgggcgga 1102381 cctggcggaa tgaatcagtc agcaacatta tacgaactac atgctgatga ataggaggca 1102441 aaaacatgag cagacatatt caatattcaa ttgttgtacc tgtgtataat gaagagcttg 1102501 tcattcatga aacctatcag cgcttaaaag aggtcatgga tcaaacgaag gaaaactacg 1102561 agctgctttt tgtcaacgat ggcagcaaag accgcagtat tgagatttta agagagcaca 1102621 gcctgatcga tccgagagtg aaaattattg atttttcaag gaattttgga catcagatcg 1102681 ccattacggc aggtatggat tatgcacagg ggaatgcaat cgtcgtcatt gacgccgatt 1102741 tgcaggaccc tcctgaactg attttagaaa tgattgaaaa gtggaaggaa ggctatgaag 1102801 tcgtgtacgc cgtacggact aaacgaaaag gggaaacctt tttcaaaaaa caaaccgcgg 1102861 ctatgtttta ccggcttctc agcggtatga cagatattga tatcccgatt gatacggggg 1102921 attttcgcct catggacaga aaagtctgtg atgaaatgaa gagattaaaa gaaaaaaatc 1102981 catttgtaag agggctagtc agctgggtgg gtttcaaaca gacagcggtc gagtatgtac 1103041 gtgatgaaag gctcgccgga gaaacaaagt acccgctcaa gaaaatgctg aagctgtcaa 1103101 tggacggcat cacgacattt tcacataaac cgctgaagct ggcaagctat gcggggattt 1103161 taatgtcagg tactggattt ctgtatatgt ttatcgtgct gtatctgaag ctattcacag 1103221 acagcacgat taccggctgg tcatcactta ttgtgatcca gctcctgttc agcggcattg 1103281 tccttctgat tttgggcgtg attggcgaat atatcggcag aatctacgat gaagccaaag 1103341 acaggccgct ttacatcgtc caaaaatcgt atggaattga aaataaaaga ctctatagag 1103401 accagcatat gtcataacct caaaccccct gtccgtaatg gacagggggt ttttatgctc 1103461 tgagcacgat ctaaagcaaa agatgctgat agatatatgg aaattgggta aagaagagat 1103521 tgtgagcttg tactgcggtt cagtcatgct gaaataaaaa cagcaaaact taaagatttc 1103581 gtcctcggct ttgctgcatg tcagctgtta tattgggggg cttttaagaa acgcatgatt 1103641 agagccgtac cagttatgtt taatagaata ctcgtaccca atacaattcc ccacgtcaac 1103701 gtcgattcag agagaagaaa gctcagcaaa agaaaagcca atcctgcgca gatcataccc 1103761 agtcccacgg ttttcatgtt catgcctcct agcaaacgat gtttctagca tctgatgtga 1103821 atgatgtcaa tctgtatgat atacggatat ctcgtcagaa agtttcatag aacaattagg 1103881 tcttttatct aataaaaagc ctcagaccgc ttttacggcc tgaggcatta tgtcttacga 1103941 agttttctct tctttttgat ccagtttaat ttttttcgtc atttctttgc cgtttcggag 1104001 aattttcact tcaacggtat caccgatctt tgcgtcttta tataagatat tgcgcaattc 1104061 actgcctgta tcaatttctt taccttttag gccgatgata atatcctccg cttttaatcc 1104121 ggccttttca gcaggagagc ctgaagcgac ctcacggatg taaacgcctt tattcagctg 1104181 gctgccgaac aggccgagtg tgccttcttg gtaattttgc ggcacttgct ctagatcaag 1104241 catgctgaca ccgatatatg gacgttcaat ttgtccttta gacagcaatt cttcagcaat 1104301 cggttttacg tcattgcttg gaatggcgaa tccgataccc tcaacatcat cctcactgat 1104361 tttcatactg ttaatgccga caattttgcc gtctgtattt aacaaaggac cgccgctgtt 1104421 acctggatta attgctgcgt ctgtctgaat gacgttaatg ctcgtttcgc cggctgatgt 1104481 agacattgaa accgttctgt ccacgccgct tacaattcct tgtgttactg tgcgggacag 1104541 gtcttttcca agcggatccc caatcgcaat aacggtctcg cctgttctaa gatcagatga 1104601 atcaccgaag tttgccactt ttgtgacgtg gtcatcactg atttggagga cggctaaatc 1104661 agttaacgag tcactgccta ccagctttgc agtaacctca gtgccgtcat ataaagatac 1104721 cttcagtgat gatgcccctt ctacgacgtg gttatttgta atgatataag ccttgccatt 1104781 ctcttttttg aaaatgacac ctgaccctga accgctttct gtatcttcgc tggaatcaga 1104841 agaactagag ccgaacaaag agctgtttga ttgtgcctga agatttgtaa taccgacaat 1104901 cgctggtgaa aggtcttcta ccatatctga gattttagaa gagtcctcgc tcttgaatgc 1104961 agatgagctg cttgagcttt ttttagattc agaggaggtg cttgttgctg taacagattg 1105021 cgtttgctgc tggctggatg attgttttgc agtgtcctga gaatcatggt caccaagcgg 1105081 tgtaaacgtg taaatgccaa gagcaagact gccgccgatc actccgccaa gcaacggtct 1105141 gaaccatccg aatcctcgtt ttttcttctc ctgatcatga atgacattgc gggccgagta 1105201 ggaggcgctc tgatcgttct ctttcgttaa aaagacctca ttctcattac ctttcgttct 1105261 gttttcatca cgatagttat ccatcatgtt cactccgttt ctctattttc acatgtctat 1105321 ttatattgat aggtttatga cttgagttta tcataaacaa aaactgtggg ataaaaatga 1105381 aaagattatg ggaaattgtg aaaaagtgcg gaaaacggta cacttcatat tgtatatgaa 1105441 aggactgagt cgatggaaca gattggattg attggatatg gcagcatggc ggatatgatc 1105501 gctagacagc tgttgaaaca tgaacaaata aaagagaatg agctatttat tgagacgaga 1105561 acgaaggggg agcggctgcg ggcactcatg tcagattatc caaacgtatc ggctgatccg 1105621 ttggagaatt gggcaaatac gtgccaattg attttgatat gcgtcccgcc actccatgtc 1105681 atcgaaacaa tgcgccgtct gtacccgtat gtgaacagaa atactcacat cgtatccata 1105741 gctgccggtg tgccgctgcg tcttttggag gcagaaacag aagccggtat ctcacgtgtt 1105801 attcctgcca ttacgtccga agcagaagcc ggcatctcac ttgtcgttca cagtgaagca 1105861 ctggctgcag agaaaaaaga acgtctgaat gaattgttat cggttttcag ccgtgtacgg 1105921 gaaatcaaag aatcgaattt agatgtggcc agcaatttaa cgagctcggc accgggattc 1105981 atagctgcaa tctttgaaga actggcactg tctgccgtca gaaacagcag cctgtccaaa 1106041 gaagaagcct ttgattttct gattcattcg ctatacggaa ctggcaagat gctgatcgaa 1106101 aaaaatatgt ctttcgagga gacgctggaa cgtgttgcaa ccaaaggcgg aataacggga 1106161 gagggagctg aggtgataca cgcctctgtg ccggacgttt ttgatgaggt atttgaaaga 1106221 accctgagaa aatatgaact gcttacagaa caggttggta aacaaacatg aatccttgaa 1106281 agaggattct ttttttatca ctgaatgatt gagatttttc ccagttatat tgcatttttc 1106341 ctcttttttt aatataattt gttagaatat tcataattta gtaaaaaagg aggagcgtta 1106401 tgaaattgta catgtcagta gatatggaag gtatttcggg tcttccggac gatacctttg 1106461 tggattccgg caagcggaat tatgaacgcg gacggcttat catgactgaa gaagcaaact 1106521 actgtattgc tgaagcgttt aacagcgggt gtaccgaggt gctggtcaat gacagtcatt 1106581 cgaagatgaa taatctgatg gttgaaaagc ttcaccctga agcagacttg atttctggtg 1106641 acgtcaaacc attttcaatg gtggagggac tggatgatac gtttagaggc gctttgtttc 1106701 tcggttatca tgcgagagcc tcgactcctg gtgtcatgtc acacagcatg attttcggcg 1106761 tccgtcattt ttacataaac gatcggcctg tcggtgagct tggattaaat gcatacgttg 1106821 ccggttatta tgatgtcccg gtattaatgg tagccgggga tgaccgggcg gcgaaggaag 1106881 cagaagagct tatcccgaac gtgacgacag ccgcagtcaa acaaaccatt tcaagatccg 1106941 cagtgaagtg cttgtcgcct gcgaaagccg gacggctgtt gacagaaaaa accgcatttg 1107001 ccctgcaaaa caaggacaaa gtcaagccgc tcacaccgcc tgacaggcca gttctgagca 1107061 ttgaattcgc caattatggc caagcagaat gggcgaatct gatgccggga acggaaatca 1107121 agacgggaac tacaaccgtt caatttcagg cgaaggacat gcttgaagcc tatcaggcga 1107181 tgcttgtcat gactgagctt gcgatgcgga catcattctg ctaaaggggt gttttaggct 1107241 ttggcgcgat acatgataaa gcgtttttgg gcaatggcag ctacgatttt ggtgattacc 1107301 accctgactt ttgttctcat gaaggtcatt cccggatctc cttttaacga ggagagaggc 1107361 acaaatgaag ccgttcaaaa aaatctcgaa gcctactatc acttagacga tcctctcatt 1107421 ttccaataca ttttctactt aaaatccatc attacattcg atttcggacc ttcaattaaa 1107481 aaaccgtcgg acagcgtaaa tgatatgctg gaacgcggat ttcccgtttc ctttgagctt 1107541 gggatgacag cgattgtcat tgctgtgatt tctgggctgg tgctgggcgt aatcgctgca 1107601 ctccgccgca atggcttttt ggactacgcc gcgatgagtc ttgcagtact cggcatctcc 1107661 atcccgaatt ttattctggc aacattgctc attcagcaat ttgctgtcaa tctcaaacta 1107721 tttcccgctg cgacatggac gagcccgatt catatggtgc ttccgaccgc agcgcttgct 1107781 gtagggccaa tggcgatcat tgccaggctg acacggtcga gcatggtcga agttctgaca 1107841 caggattata tccgcacagc aaaagcaaaa gggctttctc cgttcaaaat tatcgtaaaa 1107901 cacgcactca gaaatgcact catgcccgtc attaccgtcc tgggcacact cgtcgccagc 1107961 atcttaacag gaagctttgt cattgaaaaa atctttgcca ttccgggaat gggaaaatat 1108021 tttgttgaaa gcattaatca gcgggactac cccgtgatta tgggaacgac cgttttttac 1108081 agcgtcattc tgattatcat gctgtttttg gtcgatttgg cctacggtct cttagacccg 1108141 cgcattaaac tgcataagaa agggtgaagc gtgtgaatct ccctgtacaa acggatgaac 1108201 gccagccaga acagcacaat caggtgcctg atgagtggtt tgtcttgaat caggaaaaaa 1108261 atcgggaagc cgattcggtc aagcggccga gtttgtcata cacgcaggat gcctggagga 1108321 ggctgaaaaa aaataaatta gcgatggccg gactctttat tcttttattt ctttttgtca 1108381 tggcagttat cgggcccttt ttatcgcccc atagtgtcgt acgccaatcg ctgacagaac 1108441 aaaatcttcc gccctcagcc gatcattggt tcggcaccga tgaactcggc cgggatgtgt 1108501 ttacccgaac atggtatggc gcgagaatct cgttgtttgt cggcgtgatg gcagcactga 1108561 ttgatttttt gatcggtgtc atttacggag gcgttgccgg ctataaaggc ggcaggattg 1108621 acagcattat gatgcggatt atcgaagtgc tgtacggact gccgtatctg cttgttgtca 1108681 ttttgctgat ggtgctcatg ggaccgggac tgggcacgat tattgtggcg ctgactgtga 1108741 ccgggtgggt cggcatggcg agaattgtaa gaggccaggt gcttcagatt aaaaattatg 1108801 aatatgtact cgcctcgaaa acctttggcg cgaaaacctt tcgcatcatc cggaagaatt 1108861 tgctgccgaa tactatggga gcgatcatcg tacaaatgac attaaccgta cctgccgcca 1108921 tattcgcaga atcattttta agctttctcg gcctgggcat acaggctccg tttgcaagtt 1108981 ggggcgtgat ggcgaatgac ggcctgccta cgattttatc tgggcattgg tggcgcctgt 1109041 tttttccggc ctttttcata tctctgacga tgtacgcgtt taatgtgctg ggggacggat 1109101 tgcaggatgc gcttgaccct aagctgagga ggtagctgta tggaaaaagt tctgtcagtc 1109161 caaaatctgc acgtgtcttt tacgacttac ggcgggacgg ttcaggcggt cagaggggtg 1109221 agctttgatt tgtataaagg agaaaccttt gcgatcgtcg gcgaatccgg ctgcggcaaa 1109281 agcgttacct cccaaagcat catgggcctg cttccgcctt attcggcgaa ggtgacagac 1109341 ggcaggattc tatttaaaaa caaagacctt tgccgtctct ctgacaaaga aatgagaggt 1109401 ataaggggag ccgacatttc tatgattttt caagacccga tgacggcgtt aaaccctacg 1109461 ctgactgtcg gcgaccagct gggggaagcg ctattgcgcc acaaaaaaat gagcaaaaaa 1109521 gcggcacgga aagaggtgct ttccatgctg tcattggttg gtattccaga tcccggagag 1109581 cgcctaaagc aatatcccca ccaattcagc ggcggtatga gacagcggat tgtcattgcg 1109641 atggcgctga tttgcgagcc tgatatctta attgcggatg aaccgaccac cgccctggat 1109701 gtaaccattc aggcacagat tttagagctg tttaaagaga ttcagagaaa aacggatgtg 1109761 tctgtcattc tgattacgca cgatttaggg gttgttgccc aggtagctga cagagtcgca 1109821 gtcatgtatg ccgggaaaat ggcggaaatc ggcacaagaa aagatatttt ttatcagccg 1109881 cagcacccat atacaaaagg cctgctgggc tctgtcccgc ggctggattt aaatggcgct 1109941 gagctgaccc cgattgacgg aacgccgccg gatttatttt cgcctccgcc gggctgcccg 1110001 tttgccgccc gctgtccgaa caggatggtt gtgtgtgaca gggtgtaccc gggccagacg 1110061 atcagatctg actcgcacac cgtcaactgc tggctgcagg atcaacgagc agagcatgcg 1110121 gtgctgtcag gagatgcgaa ggattgaaca tgaaaagggg gaagaggatg aaacgagtga 1110181 aaaagctatg gggcatgggt cttgcattag gactttcgtt tgcgctgatg gggtgcacag 1110241 caaatgaaca ggccggaaaa gaaggcagtc atgataaggc aaaaaccagc ggagaaaagg 1110301 tgctgtatgt aaataatgaa aatgaaccga cttcattcga tccgccgatc ggctttaata 1110361 atgtgtcatg gcagccgtta aataacatca tggaggggct gacgcgtctt ggcaaagatc 1110421 atgagcccga gccggcaatg gcggagaaat ggtctgtttc gaaagataat aaaacttaca 1110481 catttacgat tcgggaaaat gcgaaatgga caaacggaga tcctgtaaca gccggagact 1110541 tcgaatacgc gtggaagcgg atgcttgatc cgaaaaaagg cgcttcatcg gcattcctag 1110601 gttattttat tgaaggcggc gaagcatata acagcgggaa agggaaaaaa gacgatgtga 1110661 aggtgacggc aaaggatgat cgaacccttg aagttacact ggaagcaccg caaaaatatt 1110721 tcctgagcgt tgtgtccaat cccgcgtatt tcccggtaaa tgaaaaggtc gataaagaca 1110781 atccaaagtg gtttgctgag tcggatacat ttgtcggaaa cggcccgttt aagctgacgg 1110841 aatggaagca tgatgacagc atcacaatgg agaaaagcga cacgtattgg gataaggata 1110901 cagtgaagct tgataaggtg aaatgggcga tggtcagtga cagaaataca gattaccaga 1110961 tgtttcaatc aggggaactt gataccgctt atgtccctgc tgagctgagt gatcagctgc 1111021 ttgatcagga taacgtcaat attgttgacc aggcgggtct ctatttctat cgatttaatg 1111081 tcaacatgga gccgttccaa aatgaaaaca tcagaaaagc ctttgcgatg gctgtggatc 1111141 aagaggaaat tgtaaagtac gtcacgaaaa ataatgaaaa accggcgcac gcctttgtat 1111201 cgcctgggtt tacgcagcct gacggcaaag atttccgtga agcaggcgga gacctgatca 1111261 agcctaacga aagcaaagcg aagcagctgc tcgaaaaggg catgaaggaa gaaaactata 1111321 ataagcttcc tgcgatcacg cttacttaca gcacaaagcc ggagcataaa aagattgccg 1111381 aagctattca gcaaaaattg aaaaatagcc ttggagtcga tgtgaagctg gccaatatgg 1111441 aatggaacgt atttttagag gatcaaaaag cgctgaaatt ccaattctct caaagctcat 1111501 ttttgcctga ttatgcagac cctatcagtt ttctggaagc ctttcaaacg ggaaattcga 1111561 tgaaccgcac aggctgggcc aataaagaat acgatcagct gatcaaacag gcgaaaaacg 1111621 aagccgatga aaaaacacgg ttctctctta tgcatcaagc tgaagagctg ctcatcaatg 1111681 aagcgccgat cattccggtt tatttttata atcaggttca cctgcaaaat gaacaagtaa 1111741 aaggaattgt ccgtcaccct gtcggctata tcgatttaaa atgggcagat aaaaactgat 1111801 ggaggcgatt gaggaaatac tgcttcttta tgcgaaggag cggtattttt tctctttctt 1111861 gcacgtatac gtagggtgca gagcaaatga aaggagtgtt ttcgttgaat tacaagccga 1111921 aagcgttgaa caagggtgat acagtcggag tgatcgcgcc cgcaagtccg ccggatccaa 1111981 aaaagcttga caccgcgctt ttatttttag aagagctcgg tcttcaggtg aagttgggca 1112041 aggcgctgaa aaaccagcac ggctatttag cgggacagga tgatgagcgg ctggcggatc 1112101 tccatgagat gttcagagac gatgaggtaa aagcagtgtt gtgcgcatgc gggggttttg 1112161 ggacaggacg tatcgccgcg ggcattgatt tcagcttgat ccgcaaacac cctaaaatct 1112221 tttggggata cagcgatatt acgtttttac atactgccat tcatcaaaac acaggtcttg 1112281 tcactttcca tggcccgatg ctcagcacgg atattggcct tgacgacgtt cacccgctga 1112341 caaaagcgtc atataagcag ctcttccagg agacggaatt cacctataca gaagagcttt 1112401 ctccgctgac cgagcttgtt cctggaaaag cggaaggcga gcttgtcggg ggaaatctgt 1112461 ctttgctgac gtctacactg ggcacgccat ttgaaattga tacgagagga aagcttctgt 1112521 ttattgaaga tattgacgag gagccttatc aaatcgaccg gatgctgaat cagctgaaaa 1112581 tgggggggaa gctgacggac gcggcgggaa ttctagtttg tgattttcac aattgtgtcc 1112641 cggtgaagcg agagaagtct ctctcgcttg agcaggtgct ggaagactat attatttctg 1112701 cgggcaggcc tgctctgaga ggatttaaaa tcggccactg ctcgccaagt attgccgttc 1112761 cgatcggtgc gaaagctgct atgaatacag cagaaaaaac agccgtaata gaggcgggcg 1112821 tttcagaagg ggcgctgaag acatgaaaat cattcgaatc gaaacaagcc gaatcgctgt 1112881 cccgctgaca aagccgttta aaaccgcact tcgcactgtg tatacggctg aatcagtcat 1112941 agtaaggatt acttatgaca gcggtgcagt cggatgggga gaagcacccc cgacgttagt 1113001 gattacagga gacagcatgg atagcattga aagtgccatc caccatgtgt tgaagccggc 1113061 attgcttgga aaaagcctgg cgggctatga ggccattctg cacgacatcc agcatcttct 1113121 tacaggaaat atgagcgcga aggctgctgt agaaatggct ctatacgacg gctgggcgca 1113181 gatgtgcggg ctgccgcttt atcaaatgct tggcggatat cgagatacgc tggaaacaga 1113241 ttatactgtc agtgtcaact cacctgaaga gatggcagct gatgccgaga attatctcaa 1113301 acaaggcttt caaacgctga aaataaaggt cggaaaagat gatattgcaa cagatatcgc 1113361 ccgtatccag gaaatcagaa aacgtgtcgg atcagctgtg aaactgcgtt tagacgctaa 1113421 tcaggggtgg aggccgaagg aagcggtaac tgccattcgg aaaatggagg atgcgggcct 1113481 aggcattgag cttgtcgagc agcctgtcca taaagatgat ctcgctgggc ttaaaaaggt 1113541 gacagatgca acagatacgc cgattatggc tgatgaaagt gtttttacac cgcgccaggc 1113601 gttcgaagtt ctgcaaaccc ggagcgcaga cttgatcaat attaaattga tgaaagcggg 1113661 cggcatcagc ggagcagaga aaattaatgc catggcggag gcctgcgggg tggagtgtat 1113721 ggtcggcagc atgatcgaaa cgaagctggg cattacggcc gcggcgcatt ttgcggcaag 1113781 caagagaaac atcacacgct ttgattttga cgcgccgctg atgctgaaaa cagatgtatt 1113841 caatggcggc ataacatata gcggcagcac gatttcgatg cctggcaaac cgggcctcgg 1113901 aatcatcggg gctgcgcttt tgaaagggga aaaagagcaa tgatgcacac tgtcatatca 1113961 gcagtggcca acatctggac agcgcctgat tcacctcgtc cgtctgatca attcatgctt 1114021 caaccgactg taatgatcag agactggctg gagcgcatga cgtatgatga acggcttgga 1114081 ttatgtacag acaatgtaat ccaaactcag gttctctttg gcgaaaaggt acttgtgacg 1114141 gcggaacagg gggaatgggt ttctgtgatc gtgcctagcc agccatcccg aaaggatccg 1114201 cgcggatacc cgggctggat gaaaaagtac cagctggaaa aaacaaagcc catccataca 1114261 caacacgatg tgatgatcag caaacctgct gcctttttgt acagaagcaa tggggaaaag 1114321 gagatcgaat taagcttttt gacagttctg ccccttattg caaaagaaaa cggatatttt 1114381 aaggtttcga ccgtttttgg ggaaaggttt gtgaggcaaa gtgatgcagt gcctgtcagc 1114441 caacagaaag ggactgctga agacatcatt caaacgggtg cgttttttct tggccttccc 1114501 tacctgtggg gagggatcag cgggtttggg tttgattgct ccggatttat gtacagtata 1114561 tttaaggcga atggatacag catcccccgt gatgcgggag atcaggctaa ggcagggaag 1114621 ggtgtcccgc ttgatgatat gaaagccggt gatctgctgt tttttgctta tgaggaagga 1114681 aaaggagcga ttcatcacgt cggtctgtat gtaggcggcg ggaaaatgct tcattctcca 1114741 aagacaggga agtcaatcga aatcctcaca ttaacagaga caatctatga aaaagaatta 1114801 tgtgcggtgc gccgctgttt ttcagaataa ggagggagac aaatgaggcg actgcctttg 1114861 ttagaggtca gccagctgaa aatgcatttt gacgcaggga aaaagcggac agtcaaagct 1114921 gtcgacgggg tcacctttca gattcgtgaa ggagaaacgt tcgggctagt cggggaatca 1114981 gggtgcggga aatcaacctt ggggagagtg ctgatgcgcc tttatcagcc gacagaagga 1115041 agcgtgacat accgcggcac aaatcttcat gcactaagtg aaaaagagca gtttgccttc 1115101 aaccgcaaac tgcagatgat ttttcaggac ccttatgctt cacttaaccc gcgcatgacc 1115161 gttcgagaaa ttattttgga gccgatggag attcataatc tctacaatac ccataaagca 1115221 cggcttctcg tcgtggacga gctgcttgag gcagttgggc ttcaccccga ttttggcagc 1115281 cgttatccgc atgaattcag cggcgggcaa aggcagagaa tcgggattgc gagagcactg 1115341 tcgctgaatc ctgaatttat cgtggcggac gaaccgattt ctgcacttga tgtctctgtt 1115401 caagcgcagg tggtcaacct gctgaagcgg cttcaaaaag agaaagggct tacgttttta 1115461 ttcattgccc atgatctttc gatggtgaag catatcagtg acaggatcgg tgttatgtac 1115521 ttaggacaca tgatggaaat tacagagagc ggcaccttgt atcgtgaacc gctccatccc 1115581 tatacaaagg cgcttttgtc ctcgattccg attccagatc ctgaattgga ggacaagcgt 1115641 gagcgtattc tcttgaaagg ggagctgccg agcccggtca atccgccaag cggctgcgtg 1115701 tttcgtaccc gctgtccgga ggcgatgcct gaatgtggag aatctcgtcc ccagcttcaa 1115761 gaaatcgaac ccggccgttt tgtcgcttgc catttgtatc gaaatgctga aacgaaggaa 1115821 aaagtaagat aaataaaaag agtggctcct ttttactaga gccactccat ttgtttatac 1115881 ttgatgtaaa aactttacac aaaccgggta agggacagaa accgttgatg ggaggagtgt 1115941 caatcggccg gtttctttgt ctctttcaaa caagacaagg ttgcctgttt cttcatttga 1116001 agcaacgagg aacccttccg ttgggtcaaa tacaaagtca cgaggccagt ttccttctgt 1116061 cgacactctt tctacgaaag ccagctctcc tgaatattga ttcacttcaa atacggcgat 1116121 actgtcatgg ccgcggtttg cgacataaac aaaacgtccg tcctgcgtga catgtattgc 1116181 gcttccctgg ctgttatctg taaaatcatc agggatggca gaaacgactt ggatttctct 1116241 aaattcgccg gctgtcgggt tgtattcaag cgcaatcact tcattgctta attctgtcat 1116301 gacataagcg tatttttctt tcggatgaaa agcgatatgg cgaggtcctg caccgggagc 1116361 gaaggaatgg cttccggatt cagtcaacac accgtcttta agcttatagg tgtagagctt 1116421 atctatacct aaatcaaccg ctaccacata attgtgttca ggtgtgaacc ccgcgtagtg 1116481 tgtatgcggt ttttcttgtc tttcgtgcgg cccttttcct gtgtgagcgg cctctgaaac 1116541 aggtgattgc aagctgccgt cttcctgaac cggaaaaacg tgtaccttcc cgctgtgata 1116601 attggcagtc agtacgaatt gattttgatc atcaacgctt acgtggcatg gcgaagggcc 1116661 atcaattaac tgatgattca gaaatgtcaa ttcgccgctg tttttatcga tttgataggc 1116721 agcaactccg ccttggccgt ctgctttttc gatggaataa aggatggtgt tgtttttatt 1116781 cgtcgccaca tatgtcgggt tgcccagctt agcggccagc tttggctcgc tgagtgcttt 1116841 tttctcagta tcaagctcaa atgaataaat tccttcgctt ccgccttttg tatatgttcc 1116901 cacatatcct atgtattttg tcatgcgatt tcccccttaa aaatgatgtc acctctatat 1116961 taacgtatct tgataaaata agctgttcaa aacatgaaaa aggggaagat tcttcattcg 1117021 cctcgaatca gcggcattgt gcagcacctg aaggagccgc ctgatttaat aatttctgac 1117081 aggtcaattt cgataatgtg atagcctctt ttcgatagct gttgattgac atggcggttg 1117141 ccagggagac tgatgatcgt tttttttccg attgaaagga cgttggtgcc aagcgtaaat 1117201 tgttcgtcct cgggcacctc aataagatca taacgttttg ccagcatatc ggctgcatct 1117261 ggctcaatgg cctgtgaata aattaacgct tcgctttcag atataatgtt aaatacgcag 1117321 tccaaatgca aaaatttttc atgaagcttc actggaacga tcgtatattc aggaagtgcc 1117381 tcttctagct ggccgatagc tgaaatgtcg gtgcgctggc tgattccgac atagacaatg 1117441 tcatcatcga taatgacgtc tccgccttca atactcgtat caagcatgcg ggtgtaagag 1117501 ataccttggc tgtgaaaaaa atcttttata acggcttctt ctccttggcg aatcggttca 1117561 gtcatgcttg acagaaaggc tttttctccg atgacaaatc ctatgtccct agtaaaaacc 1117621 tgttctggga gtccgtcgcg aacgggcaaa aggacgacct caacgttgtg tgacctaagt 1117681 gcctccacta agcggctgtg ctggtcgtta gcggttttta catgaatatt gtcatcttca 1117741 aaatgttttt gtgtttcgtt tataacatct tttatggtca tgtgctcagg tttgcataag 1117801 atcacttttt gaagtgtgcc gtattccgtt cggcataccg ttttgtgctg agatttcggg 1117861 atggatacgt ccatttgttt ttcctcctaa agtgtgaaga atacatttat tattccctca 1117921 tcatgaaaat cattaaacca ttttaaattt tagacaaatg gaagagaata ttgtttaata 1117981 ggagaatata agtgcattta gctaaaagat cagacatcaa aggggagaaa ggtatggaaa 1118041 caccggaaac aagattttgt aaagagtcaa aggttgtgaa aaccagcagg gtgttcccgc 1118101 ttgacacgaa caaccataat acgctgtttg gcggaaaatt aatgagctac atagacgaca 1118161 ttgcctctat ttcagcggcg cgccattgca gacgtgaaac ggtaacagct tcaatggatt 1118221 ctgtagattt tttaaagccg atcgggcaaa aggattctgt ctgcctagag tcatatgtga 1118281 catgggtcgg cacatcttcc atggaagtat ttgtgaaagt tattaaggag catttgatga 1118341 ctggcgaacg ggaactcgct gccacatcct ttttgacatt tgtcgcatta gattcaaatg 1118401 gcaagccggt gcctgtaccg agggttgtac cggaaacaga agaagaaatc atgctgcata 1118461 atacagctgt acagcgtgct aatgaacgta agaaccgcaa gagacacagc caggcgcttg 1118521 caaatgcgct cggaactgat aagccttggt gaacgttaaa cccaaaacat aagttgtttt 1118581 gggttttttt gtacttttca atggtgatta ttacaatggt tagtccgttt ttgctagggg 1118641 attctataaa aaagcaacaa atgtcatgtt aaattgataa ttttgtgaca actttattaa 1118701 agattcattt tagatatatc ttttattcgt aagatcatgt attttaaaga tatattttaa 1118761 atacatcttt tcgaaaggat tgtttataaa atgttagata acaaaacaat cgaaattatt 1118821 aaaagcactg tacccgtatt gcaacagcat ggagaaacaa tcactggccg tttttacgat 1118881 cggatgtttc aagaccatcc agagcttttg aacattttta atcaaacaaa ccaaaagaaa 1118941 aaaacacagc gaactgcact ggcaaatgcc gttattgcag ctgcggcaaa cattgaccaa 1119001 ttaggaaaca tcattccggt tgtcaaacaa atcggccaca agcaccgcag tatcggaatt 1119061 aagcctgagc actacccaat cgtcggtaaa tatttgctga ttgcgattaa agatgtattg 1119121 ggagacgctg caactcctga cattatgcag gcatgggaaa aagcgtacgg agtcattgct 1119181 gacgcgttca tcggaattga aaaagacatg tatgaacagg ctgaagagca agccggcggc 1119241 tggaaggagt ataagccatt cgttatcgca aaaaaagagc gggaaagcaa agaaattaca 1119301 tccttctatt tgaaaccgga agacagcaag ccgttacctg aattccaagc agggcaatat 1119361 atcagcatca aagtgcggat tcctgattct gaatatacgc atatccgcca gtacagcctg 1119421 tctgatatgc cgggaaaaga ctattatcga atttcagtga agaaagatgg tgtcgtgtct 1119481 tcctacttac acgatgggct gcaggaggga gattcaatag agatcagcgc accggcaggg 1119541 gactttgttt tagatcatgc atcacaaaaa gatctcgttt tgatcagtgc cggagttggc 1119601 attacaccaa tgatcagcat gctgaaaaca tctgtttcca aacagcctga acggcaaatt 1119661 ctgttcattc atgcggcgaa aaacagtgaa tatcatgcat tgcgccatga agtagaagaa 1119721 gcagcaaaac attctgctgt taaaacagca tttgtgtatc gcgagccgac agaggaagac 1119781 cgtgcaggtg atctgcattt tcatgaagga cagattgatc agcaattcct caaagaactg 1119841 attgccaaca cagatgcgga ttactatatt tgcggttcac cgtcgtttat tacggcaatg 1119901 cataagcttg tatcagagct cggatcagcg ccggagtcta tccattacga gctattcggc 1119961 ccgcaattaa gtttggcgca gtccgtttga acacatacat gaaactcttc tcctttcaga 1120021 gaagagtttt ttattgagat ataagaaggc agacaagcgc cggtttctac atccggacaa 1120081 tcacagaccc gctgccattt gtgcatacac ggttttgctg ttcttgcatt gttctcagca 1120141 attcattgtt tacctcaatc gctctaatta gttgcttcat tcttagctcc aaaccggcca 1120201 gcctgtcgat tgtttgctgc tggtagccct cgggttgggg agccaatggc agatcaaagg 1120261 gccaaagggt attcgacttc tgatttttca tattgcgtat tgcgcctcca atcggtgtca 1120321 ctttctatta tgttatgttc aggcgatatg cacgttcgcc tagacactga tgcatagagg 1120381 gcctgccacg gggcacaata ggctcaatat gaccagcgga tggaggtaaa gatcggtgtt 1120441 atggatggta tgggtatttt tactgaagcc agttatcgta ttttcgattg catatatttt 1120501 gtttcggctt gccggtaaaa aagctgtgtc acaaatgaac aattttgacc tgcttttgac 1120561 cttcgcaatc ggaaccatta tcagtgagcc gatccttaca tccaagctgc cgatgtcaat 1120621 ttattatgcg ggtgcttttt tggtgcttta tcttatcatg agcaagctct ctttatctaa 1120681 taaatggcga tggctcctag tcgtgagccc gactgtccta atccgaaacg gggatattga 1120741 tgaacgcggc cttcgtaaag aaaggctgac tgttaatgag ctgctcggaa agctgaggga 1120801 aaagggctat gccgacccgg ctgacattga tcttgctatc attgaagaaa cgggagaagt 1120861 aagcgtcatc ccgaaagagg aagcgagagc ggtgcaggtg cgggatttga atatggaagc 1120921 tgaacggaat tttatcccga ttccgctcat actggatggc gaaatccttg atcataattt 1120981 gaaatatctc caaaaaaacc gatcctggct gtttgagaag cttgaggaaa aagggtacag 1121041 ccccaaactg ctgtcttcga ttatccttgg cacgatgaat gcacgcggtg atatatccct 1121101 tgatttaaat accgctaatg aaccgcagca tgatccttac ttatataaac cgggaaataa 1121161 caattaagat ggctctctct tgtaatgaga gcttttttct tttttaaagg gaatttttgt 1121221 ttggtgtcaa atgtacctag ttaggagggg aactgaacat gaaggactta tccataagaa 1121281 acgacatggc gccaacggtc agtttgctgt attccgcagt ggaagaaaac agtctccgtc 1121341 tggcttccat cgtaagccat atgacacaca gtgaacttta ctataagggg cgctgccaaa 1121401 caaaaaacag cacggctcag cttttgcacc atatcacaaa tgttgatatc agatgggtct 1121461 ggcgtatcaa ggaaaatcgg atcccggacc atattgaaca ggcatacggc ccgatgacag 1121521 atgaaagcgg acggctgcct gaaccggtga atcagccaga cttagatgaa ctcctgaaaa 1121581 gacatcagca tgtagtagag aagctgaaat cggtatgctt cactttaact gaaaatgctt 1121641 tgaaccagcc gctttccttc gaaggtgaca ccgcgacgat acgatgggga atttggcata 1121701 tggcagatca taaccgctat catcaggcac atattgaagc tctcaaaaaa gaatggaagc 1121761 aggatgtggc gaagtatgaa cgctaaaacg aagcttgtga ctgatcgaat tcgtttgcgc 1121821 tgtatggaag atcgggatca agccactttg tttgggctgc tttttaatga tcctgacgtc 1121881 atgacatatt attccggttt aaaagataag aggcaaaccc gcgagtgggt caattggaac 1121941 caacgaaatg aaaaagggta cggcgttagt ctgtggatcg ccgaagataa gcggacaggg 1122001 gagtttttgg ggcaatgcgg catcgttccc cagcagatcg aaaatcaaac cgtaatggaa 1122061 attggctata tgtttgcccg ccgccactgg gggaacggct atgcgcaaga agcggctcgg 1122121 gcctgtctgg actatggctt taacgagcgg cagttcggca aaatggcggc tttgattgat 1122181 ccgggtaaca aagcgtccat acgggtagcg gagaaaatcg gcatgcatta cagcaaaacg 1122241 atcagaaaat ggaataaacc gatcgcggta tatgaaagaa aatcttacaa ttgaaagata 1122301 gagctgagtt tagtatcatg atatcatgta aagttttcta gggttccgca tgtcaattga 1122361 catggactgg tccgagagaa aacacatacg cgtaaataga agcgcgtatg cacacggagg 1122421 gaaaaaagcc cgggagagtc aatctcatgt gagacgactg tccggggttt ttttgttttc 1122481 ggagaatctt aatagataga aaggaatgac tcaaaatgaa atggggattg gtcgtgcttg 1122541 ccgctgtttt cgaggttgtt tgggtgatag gcttaaagca cgctgactca gccttaacat 1122601 ggagcggcac tgccatcggc atcatattca gcttttacct tctaatgaag gcgactcaca 1122661 gtctgcctgt tggtaccgtg tatgccgtct ttaccgggct cggcacagcg ggaacagtac 1122721 ttagtgaaat cgttcttttt catgaaccgg ttggatggcc gaagctattg ttaattggcg 1122781 tgctcttaat cggtgtaatc gggttgaagc ttgtgacaca ggatgagaca gaggaaaaag 1122841 gaggcgaggc ataatgctgc actggatcag tttattgtgc gcgggctgtt tagaaatggc 1122901 cggcgtggcc cttatgaatc aatatgcgaa agaaaaaagc gtgaaatggg tgctgttgat 1122961 cattgttggt tttgccgctt cattttcctt gctgtcgtac gcaatggaaa ccactccgat 1123021 gggaacggct tacgcggtct ggacaggaat tggcaccgcc ggcggggcgc ttatcggcat 1123081 cctcttttac aaggagcaga aagacgccaa acggatcttc tttatcgcgt tgattttatg 1123141 ctcagcagtt ggtttaaaaa ttctgtcata aattgatttt tatcaaatct tcagtataat 1123201 ggataaatag tttagactta caaagataag agggattatt catgaaatca tatatgactc 1123261 agcggttgga cgaataccgt gacggaaatg aggataaagg tcggctcttg gtcagctgcc 1123321 ccgatcagcc gggtatcgtc tctgcagttt ccgcgttttt atttgaacac ggtgccaata 1123381 ttatagaatc aaatcaatat acgacagacc ctgaaggcgg ccggttcttc ctgagaatcg 1123441 aattcgactg cgcaggcatt cgtgaaaaaa aatcatcact tcaggcagcg tttgcctctg 1123501 ttgcggaaaa attcgacatg acatggagct taactttggc gagcgaactg aagcgtgtcg 1123561 ccattttcgt ttcaaaggag ctccactgcc tgcatgagct gatttgggaa tggcaaaccg 1123621 gcaacctgat ggcggagatc gctgttgtca tcagtaacca tgaggaagcg agagagctgg 1123681 ttgagcgcct gaacattcca ttccactata tgaaagcgaa caaagacatc agagcggaag 1123741 tcgaaaagaa gcagcttgaa ctgctggagc agtacgatgt tgatgtgatc gtgctcgcac 1123801 gctatatgca gattctaact cctgattttg tttcggctca tccgaatcgc atcatcaata 1123861 tccaccattc attcctgcca gcttttatcg gtgcgaatcc gtacaaacgg gcctacgagc 1123921 gcggcgtgaa actgatcggt gcgacatctc attatgtgac aaacgatctt gatgaagggc 1123981 cgatcattga acaggatatt gagcgtgtgg accaccgcga taatgcggaa gcgctgaaaa 1124041 acatcggaag aacaattgag cgcagcgtgc ttgcccgtgc tgtgaaatgg catttggaag 1124101 accgtgtcat cgttcatgaa aataaaacaa tcgtctttaa ctagactgca agaggcccgc 1124161 gcaatgcggg ctatttttga tgacaaaaaa ccttgacaag tgtctttttt ctttgcataa 1124221 tataaaaaaa tcattgagcg ttgaagagga ttagtaagca gacctttctg tgacagagag 1124281 caaaatgaat cgctgaaaca ttttgccgca tgaaacctgc cgaacctgcc ttggagtcct 1124341 agggggaaaa cctaggcgca taacctggcg ttacaggaga gcggagcgtg cacaagcgcg 1124401 ttcaatcaag gtggtaccac ggaaacccat ttcgtcctta tgaatcagga tgaaatgggt 1124461 ttttttattg tagaagagcc gcggaggaga ataaatgaaa aaacaaagaa tagtagtgaa 1124521 aataggaagc agttcgctca cgaatagcaa aggaagcatt gatgaggcaa aaatcagaga 1124581 gcatgttcag gcgatttccg tgttaaaaaa agcggggcat gaaatgattc tgattacctc 1124641 gggtgccgta gcggcggggt tttccagcct cggttatcca tcccgtcccg ttaccatcaa 1124701 aggaaaacag gcggcggccg cggtcggaca aacactgtta atgcagcaat atatgaatca 1124761 atttaaacaa tactcactga ctccgggaca aatcctttta acgagaaatg atttttcgaa 1124821 aagagaacgg tatcgaaacg cgtatgctac gataatggaa ttattagagc ggggcgtcat 1124881 tccgattatc aacgagaacg attctacatc tgttgaagaa ttgacattcg gagataatga 1124941 tatgctttct gcgttagtca gcggattgat tcacgcggac cagctcatga ttctcactga 1125001 cattaacgga ctgtatgatg ccaatccaaa tgaaaatcct gaggcgaaac gatttgatta 1125061 tttgccagag atcacgcctg aattgcttgg atatgcaggt tcagctggat caaaggtcgg 1125121 caccggcgga atgaaatcaa agctgttagc cacacaaacc gcgctgtctc tgggagtgaa 1125181 agtattcatt ggaactggca gcggagagca aaaacttgcg gacattttgg acggcagggg 1125241 agacggcact tatatcggag acaaagaact atcttcggtt aacaacacaa ggcagtggat 1125301 tcagttccac tcgccgatat cgggagaaat tatcattgat gcgggtgccg aagaggcgat 1125361 gatccataat ggaagcagcc ttttgcccgc tggagttgtg ggcgtgaacg gaagctttcc 1125421 gaaaggggcg gttgtggaag tcaggggacc gggcggcgtg atcggcaaag gccaaactca 1125481 ttactcctcc gaggagatta tggaggctaa aggcaaacgc agtgacgaac ttgattttga 1125541 gaaaacgttt gaggttattc ataggaatga ctgggtcaat gtaaaagact aggaggcgga 1125601 aaaatgagtg aagtttctgt aaaagcgaag ctggcgaaag aagcagcagc cgaaatgatc 1125661 atgaaaacaa cagccgagaa ggatgaggcg ctcagcctca ttgcaaacgg actccgcaaa 1125721 gaactggatt ttctcttggc ggagaatgca aaagacattg tgaacggaaa agagaatggt 1125781 ttaacaccgg acatcattga ccgtctctca ttggatgaga aacggatacg cgatatcgcg 1125841 gacgcggtgg agctcttaat cgacttagcg gacccaatcg gcgactctct tgaaacgatt 1125901 gaaaaagaaa acggcctgtt tattgaaaaa atccgtgtgc cgctcggtgt cgtaggaatg 1125961 atttatgagg cgaggccaaa cgtcacagtt gatgcggcta ccctttgcct gaagacaggg 1126021 aacgcggttg tgctgcgggg aagctcctca gccatccaca gcaacaaagc gctcgtcagt 1126081 gtcatttaca gagcacttga gcaatcagcg cttccgattc acgctgtgca gctgattgag 1126141 gatacgagca gagagacagc aaaagagctc tttacgttaa atgatggctt agacgtattg 1126201 attccgcgcg gaggcaagaa actgattgat ctcgttgtga gagaatcaac agttcctgta 1126261 ttagaaacgg gagcaggaaa ctgccacata ttcattgacg aaacagccaa accgcaaatg 1126321 gcagaaaagg ttgttgtaaa tgccaaaacg cagcgccctt ctgtatgcaa cgcgattgaa 1126381 tcattgctga ttcacaaggc ttgggcaaga cagcacggaa aagaattgct ggaccagctg 1126441 gaaaacgcgg gagttgaaat tcgcggtgat gaattggtat gtgaacttca tccttcaagc 1126501 aaacaagcat caaaagaaga ttgggaaacc gaatttttag cgcctgtcct cagcgtaaag 1126561 acggttgaaa acgtccaaga agctgtaaag catatccaac aatacggcac caatcattct 1126621 gaagcgattt taactgaaaa tgacaaaaat gcggtatatt ttcaaacggc tgtcgatgct 1126681 gccgctgtct atcataacgc gtcaacccgc tttaccgacg gctttgaatt cggctacgga 1126741 gccgaaatcg gcatcagcac gcaaaagctt catgcaagag gaccgatggg gcttcctgca 1126801 ctgacttcta caaaatacat cattaaagga actgggcaaa tccgtgaata gcggggtaat 1126861 gttcaatgaa aaagcttatc tcattacgag ataagctttt ttatacgcga aaaattgaca 1126921 tttcaaattt aattgtgtac aatttaattg tataaaatat attgggggaa tgaaaaatga 1126981 gtcagccatt atttaccgca actgtttcag cggtaggagg aagagaagga aaggtcattt 1127041 catcagaccg cgttcttgag cttgatgtcg caatgccggg gacaccgaga gccaagaaat 1127101 tagaaaaagc gacaaatcca gagcagctgt ttgcagcagg ttatgcagct tgctttgaca 1127161 gcgccctgca gcttgtcgca agaacagaac gggtaaaagt agagacagag gttacagcaa 1127221 atgttagcct gttaaaggat gaagcggacc agggctataa gctgggtgtg acgctgcaag 1127281 taaaaggaga aggagtcagt gcatcagaat tggaggcgct tgtgaaaaaa gcgcacggcg 1127341 tctgcccgta ctcaaaagca acctccggaa atattgatgt gacacttgaa gttgctgaat 1127401 aaataaaaag aggatgcctg tacaaggcat cctcaatttt tttgatgaag tgtttccagt 1127461 aatgtatata gagcggactt taactgtttg agatcctccc cagactgctt tgagagcccc 1127521 agaattgtcc ctggaatgtc aaccgctttt tcttttaata acgctccgtc ctctgtcagg 1127581 ctgatcaaca cggaccgctc atcctcttca gatctttttc tcgtaatcaa accctgttgt 1127641 tccattcgtt taagcatcgg agtgagcgtt cctgaatcta aatacagctg ttcgcccatt 1127701 tttttgacag taagcgtttc atgttcccat aacaaaagca aagccaaata ttgagggtat 1127761 gttatattca gcttatcaag cagcggcttg tattgctttg tcatctcccg cgaactcgca 1127821 tatagcaaaa aacaaagctg attctccaat ttcatatgat caaatttatt ttccattttg 1127881 ttcaccaact cttttttgtc attcgattct attgtatctg aaaaacctca cttttcctat 1127941 tctcggcaaa catagcatgt ttaaaaagat cagaaaggga aatataacaa ctagatacaa 1128001 ataaggaggt tgggaaatat ggcactattt acagcaaaag taaccgcgcg aggcggacga 1128061 gcaggacata ttacatcaga tgacggtgtt cttgattttg atattgtcat gccaaatgcc 1128121 aaaaaagaag gacaaaccgg cacaaatccg gaacagctct ttgcggcagg gtatgctgca 1128181 tgcttcggcg gcgcgctcga acacgtagcc aaagagcaga atatcgaaat tgattcggag 1128241 attgaagggc aggtcagcct catgaaggat gagagcgacg gcgggtttaa aatcggtgtc 1128301 acacttgttg tgaacacgaa agatttagat cgggaaaagg cacaagagct tgtcaacgcc 1128361 gctcatgaat tctgtcctta ctcaaaggca accagaggaa atgttgatgt aaaactagaa 1128421 ttaaaataat gaccggcatc ctgaggattc tcaggatgtt ttttggtgtc ggacatgcgg 1128481 ggcgggcaca gatttatgat aaaacttcag agaagcgttt gaagcatgcc tttaaaccaa 1128541 aagttacaga tgaagcgggt ggctggcacg gtgtctgccg tgctgaattg cgcgtatatg 1128601 ctgttttgta tttgcacagg gcatagcggc tacttggaga aataacaagg accaggccgc 1128661 gcatgcctga tccttttaat attctttctt attggcgaag ttccgccatg cttgaaacgg 1128721 ggataaatgc tctgttagtg tcacttgata aaaggggatc gttctttctt cagcaggttt 1128781 atcaatttct ttataaatga atgaatcatc aaacccggct tcggcagcgt ctgtgtgctc 1128841 agctgcatag aaaacggctt taggccgggc ccagtagatg gcgcccaagc acattgggca 1128901 tggttcacag ctcgtataca aaatgcagtc atcaagctgg taggctccta gcaccttaca 1128961 ggctttccga atagctgtga cttccgcgtg ggcagtcgga tcattgcttg ttgtgacgtt 1129021 gttctgtccc tctgcaataa tggctccgtc tttcacgata acggctccaa aaggcccgcc 1129081 gattcctgca ttcactcctt cacatgcgag agtgacagcc cgttttaaga acgtttcatg 1129141 attcatccca atccctcctg tcaatagagt gttattagta tagccgaaaa gaatgcaaag 1129201 aacattctta aaaaagtgca aaataaacaa agtatttggg ggatttgcta aataagaaac 1129261 cgattgtggc tgtattatag aaaaaaacca tctgccaaat gcagatggtt ttttcaaatt 1129321 atactagctg tgtctgctgt gctcttgcct gttttgcggc ttcaaccata tttttcaatg 1129381 ctgcaaccgt ttcttcctgc tgtcttgttt tcaatccgca gtctggattt acccagaagc 1129441 ggtcagtcgg acagacggca agcgcatcaa cgataatatt gtacatttct tcagttgacg 1129501 gcacacgagg gctgtgaatg tcatatacac caaggccaag ccctttcaaa tacgggtggt 1129561 tttttaagta atctaaaaat cctccgtggc ttctgctatg ttcgattgta atcacatcgg 1129621 catcaagatc attgattgta tcaacgatat cttcgaagtt gctgtagcac atatgtgtat 1129681 gaatttgtgt ctcgtttttc acggaagaag tggttaatct gaaagcttct gccgcccaag 1129741 tcaaatactc atcccaatcg cgggttttca atggaaggcc ttcacgcagc gctggttcat 1129801 cgacttgaat gatttgaatg cctgcgtctt caagcgcttt aacttctttg cgaagggcaa 1129861 gcccgatttg gaaggcgatt tctttcctcg agatgtcgtt tcgagggaaa gaccagttta 1129921 agattgtaac cgggcccgtc agcattcctt tcacatgctt ggaagtcaat gactgtgcgt 1129981 agactgtgtc tttcactgtc atcggttcaa taaattcaac atctccgtaa atgactggcg 1130041 ggcggacaca gcgtgagccg tatgattgaa cccaggcata tttagtgaag gcgaaaccgg 1130101 ccagcttttc accgaagtat tcgaccatgt ctgtccgttc aaattcgccg tgaacaagga 1130161 catcaagctc caattcttcc tgaatatcaa tccatctttt tgtttccgca ttgataaagt 1130221 tttgatactg ttcatcggac cactcagctt tccgccattt ttggcgtgcg ctccgcactt 1130281 cagcagactg cgggaagctg ccgatcgttg tcgtcggcaa aagcggaagg ccgagagatt 1130341 cattttgtag ggctaaacgt tcttcaaacg gaatcgggcg cttgaagtct ttatcagtta 1130401 attgctcaag ctctttcttt tgttcagaat tggcgcctgt tgcaaactgt ttaagcgcct 1130461 ggatatcagc cttagcctgc tgaatctctt cgctgatcgc cgcttttcct gatactaagc 1130521 cttctttcaa agctgtcagc tcggccagct tttcttttgc gtaggataat ccgttcaata 1130581 ggtctttttc caaatgctca tcagggtgtt tcgctactgg aacatgcagc aggctgctgg 1130641 aaggctgaat ccacagttca tcaacttttg caatgctgag aatatcaaga acggcatcga 1130701 gacgctcttc aaggtccgct ttccaaatgt tgcgtccgtc gataacgccg gctgccagca 1130761 ctttatctgt cgggaagcca tgtgttttaa gctgttccag gtttctgcct ttgtcgtgaa 1130821 cgaaatcaag gccaattccc tgaaccgggt aagagatcag ctcttcataa gcatcaacag 1130881 aatcaaaata cgtctgcaaa agcacattca aggatgaaag ctcacttgta atgctttcaa 1130941 ataattcttt tgcgccgcgt acatcttcac tagaggcggt aacgagcgcc ggctcatcga 1131001 tttgaaccca ttttacgcct tcttcttcaa gctctttcaa aagctgtaca tataatggca 1131061 caaggcgttt ttggatcgct tttgcttcag acggttcata gcctttagca agcgtaacga 1131121 acgtataagg gccgacaatc acaggctttg tttccacacc gtattcctgt ttgatccggc 1131181 gataatcttc gagttgtttg tttcttgtca gacggaactc aatgctctcg tcatattccg 1131241 gaacgatgta atggtaattt gtattaaacc attttgtcat ttcactagat acagcgtctt 1131301 tgattccgcg ggcgatagcg aagtatgtat cggtagcgtc agtcaaatgt ctgaaccgtt 1131361 tcgggatcca gttgaagctg actgctgtgt cgagtacatg gtcatactgt gtgaaatcag 1131421 aaacaggcac aacatcaatc tgctggtcaa tttgtgtttt tactgcggat aaaaatagtt 1131481 cgtcgatttg cttcaaaaac gtatctttat cagtactgcc tttccaatac gcttcaagtg 1131541 cttttttcca ttcccggttc agtccgattc tcggaaatcc taaattcgat gttttgatgg 1131601 ttgtcattgt ttctcctcct ttatatgtaa aacactctct ttcacccgcg gatacaggct 1131661 gctaagaggt tttctcacaa caaaaagcct ctttcccatg agagaaagag gcttttctac 1131721 gtaaaacact gcctctctca tctctcagac acaatctgat ggaattagca ccgtgcctta 1131781 tgagacatca gtctcggcgc gaaaagcagt gcgccccatt tcacaatggt attacggtcg 1131841 gttgctgttg gggtcaaaag gccaatccct cgcccaactc tcgataagag aaaatgttat 1131901 taattttttg aaaagttgaa tcatttgttg gtaatcttaa cagtaattca aattcattgt 1131961 caacatagaa tttgaaattt ttatttacat gatgtggtgt atattatata agaaaaataa 1132021 tcttataggg tcaacaaatg tgattgctct gctttttctg cgagctcatc aggagctgtt 1132081 aaatacagga atccattgcc tgccagcgtt tttgcaatat caagaggaag tgtcctgcgg 1132141 attagctgtg cgaaaacctc agattcagaa agctttcttt gaaatgattc ttcttcatag 1132201 cttttgatta aagcaagcgc accgctgaca tgaggggcag ccattgaagt gccggtcagc 1132261 ttaccgtact tcttgttggg aagggtggat aagatgtttt ctcctggtgc cacaaggtca 1132321 atctctttat tcgcgttaga aaattctgat aattctcgcg ctacagaaac agatccaact 1132381 gcaatcactt cattataagc tgcggggtag gaaagctctt ctgtgcgttc gtcgccgtca 1132441 ccttcatttc ccgctgcaca aacgacaagc actccgtttt tcactgcgtt tttcactgct 1132501 tcttttagct ctggcacatc gcttggccct ccaagggaca ttgagatgat gtcgactttc 1132561 tgttccaccg cgtagttgat gccgttaatt atccattcgt attgtccgct gccgttctcg 1132621 ccgccaagaa ccttcacaat caataggctt gcctcaggcg cgactccggc aatgcctccg 1132681 tttgaatcat tagctgcaat tgttccggcg acgtgtgtgc cgtgtccgtt gtagtcggaa 1132741 atcgcatctt ccttgccgcc gtcgtcatcc gtgaagttct ttccgccgat gatttgattt 1132801 tttaaatcag ggtggcttgt gtcgcagcct gtgtctaata cagcaacttt aatatttttg 1132861 ccttttaccc cttttgccca catttctggc gccttaatca ctttaatgcc ctcaggaagc 1132921 tcgtttacat ccatgatctg ctcattcgtc acatacggga tcaagcggat ttcaccattc 1132981 ataaaaaagc cctccttttt tatgcttgca agtggattca agggtgttgc ctcatattat 1133041 atgaaaaaag caagcgctcg gacagagcca tttgaagcat tttgaaaaaa taggatacac 1133101 accaaagaat tagtaatctt caaaatattg gatggcttca acatgtatga ctgggattca 1133161 actgtaagtc aagttataat agtgttgggg aaaggagcag tgtcatgaaa ctgaatgaaa 1133221 aattatatgc atttttttca gagcatgtgg aacaaatggc cgaggaatgg attgaaacga 1133281 tggaggaaag tgatccgaat tcgctttacg ccctacataa tgcaacagta acggaagaat 1133341 tgaaagagca ggacagagaa ttttaccggc atctgaatta catgtatgtt ttaccggaaa 1133401 aacaatttct cgaagagttt caagagtggg tcattgagct gaccaacgat caaaaacatc 1133461 tcgacacacc ggttcagtat gtcattcggg agtttatgag aaacaggaga ttatatacga 1133521 agtattttga gaagttcgca gaagaaaatg aatcagcgtt tgaaccggga gagaagcaaa 1133581 aatgggcaga tttgattgta aaagtatttg atttcaccat ttatacattc gttgatcacg 1133641 ctgaaatgaa tgccaagcag caattaaacg cccaaagaga aatgatattg gaattaagct 1133701 cacctgtcat taccctgagc aaatcaacag ctctgctgcc gcttgtcggt gacattgata 1133761 ccgaacgggc gaagtttatt ctggaaaaca cgcttcaagc ttgtgcgaaa agacgtgtgg 1133821 agcatctgtt aatcgatctg tcaggtgttg ttgtggtgga tacgatggtg gcgcaccaga 1133881 tctttaaatt gattgaggcg cttaatctga tcggtgtccg gtcaaccctg tcaggaatca 1133941 ggcctgaaat tgcgcaaact gctgtacagc tggggattga cttttcgaat attactatta 1134001 aaaccaacct tgcccaagca ttaaactatc atcaataaaa aaatccgcta tctgtgatag 1134061 cggatttttt atgatgcgaa acataaagat acgagaaagg atcccgcgaa taataagagg 1134121 acgaggcaaa agaacaccca gtcgcgccgg ttcacgctca atgtcctgta gtatgtccgg 1134181 tttctgcttc ctgtaaatcc tttcgattcc atcgcaagcg ctgtccgttc cgcttttctg 1134241 atggcgcttg ccaatagcgg tatggtatat cgttttaacg cactgatttt attaatgatg 1134301 ccgctctccg ccgctcctcc tctgatttta tgagcctgct gaatcagctg gacctcatcc 1134361 tttaacagcg gaagaaagcg aaagcctgca atgacaccgt acgcgagctt tggtgagagc 1134421 ctgcactgct ggacaaggct cagcataaat agaatcggat cggttgtaaa aacaaacatc 1134481 atcgataagg cggaaaagca taaaatacga aacccgagag agatgccgac agacacatta 1134541 tcgctgttaa tggagatagg gcctgcttga aacaaaaaat tatccggtgt tgtcggcact 1134601 tttccaaaaa ctgcggctgt ccacacgcat ccgaatgcta aaatcaaaaa cggaatcgta 1134661 aacaacaacc attttttcaa tgggattccg gccgccagta aaacgcccgc aacgatgatg 1134721 atataaaaac atgccggagt gtaagggttg taaataaacg acagcatgac gacacaacaa 1134781 aaaaccgccg ccgctttcac agtcggatta atgagatgta acggttgctt catcacgcac 1134841 ctcctcttga aatgccatcc attcatatag aaggggaagg gtgagctttg ctttttgaac 1134901 aagccctgtt tcttgagaaa acaactgcgc tggagatccg tcaaaggcca ggcctgtatc 1134961 gtgaagcaca agcacgctgt cagcatacga agagactagc tccatatcgt gtgtaatcat 1135021 aaggacagca gttccctctg ccttgatacg ttgaatcatt tccatgcatt cagccgccgt 1135081 gcgggcatcc tggccaaagg ttggttcgtc taataataaa acctttacgt catgcatgag 1135141 catagtagct acgctcagtc gccgtttttg cccttggctg atcgcaaacg gatgatgatc 1135201 agccaaatgc gcaagaccaa aacgctgcag caggtgttgc gcttttttct cagtttcagc 1135261 atttgctttc tggccgaaca gaagctcgtc atacaccgta tcggtgacga attgatgctc 1135321 agggttttga aaaacaaatc ccatccgttt acgcaattct ttttctttat atttctgcag 1135381 cggctgatca tagagaagga ttttgccgct ttgcggtttc atgagactgg ccagaactga 1135441 taggagcgtc gattttccag ttccgttcgg accgacaagc gccgttaaag agccttcgcg 1135501 caacgaaaag ctgatgtctt tgaaaatcgc ctgctgtcct ctcgcgaacg aaaggctgct 1135561 gacttcaagc acactctccc cagaaggggc tttcttcttt ttgacatgcc cggcaggaat 1135621 aggctctttg aacagcatct cttttgataa agtaaacggc atactcagct tttcctgcag 1135681 atgacagacc tttggaatgg cgatgcccaa tttctttagt gtctccgctt catgctgaaa 1135741 tagatttttc gtcaggccat ccagtgcctt tttgcctgat ttgtcgagta cgatcgttct 1135801 ctcaatccaa ggcgcccatt catcaagctg gtgctcaatg acgaggaggc tgaaaccttt 1135861 ttcccgctga agatccttca tcagatgaac gaactcccga gctgagaaag ggtctaaaag 1135921 agaggtcggc tcatctaaaa taataagctc aggctccatc gccaaaatac aggcgagagc 1135981 cactttctgc ttttgtcctc ctgaaagggt tgagatcatt ttttctttta aatgggtaat 1136041 gcgtaatttt tctaatacgg cgttgatttt ctctgtcatt tcttcttttg gaatttgcag 1136101 attttccagc ccgaacgcta tttcgtcctc caccgtcagc atgcagaact gctgatcagg 1136161 atcctgaaaa acgaccccgg catgctgagt aatcgtttcg gaggtttcag catctgtgac 1136221 cggcttttga aatagaaata catgtccgga ctgaatgccg tcgcaagcct ccggatatag 1136281 accgtttaaa caaagggcga gcgagctttt accgcatccg ctcggtccta ataataaaac 1136341 acattctcct ttttgaagct caaacgaaat gtcttgaaaa accggtttct cgtcttcttc 1136401 ataagagaag ctgagctgct caaccgtcag aagctcatca aaggcttgca tgttctgacg 1136461 cccgcttccg tttctttttc agttcctttc cgagtgccat tccgtttaac acacctgtat 1136521 aagcgagaga gtcgctgaca gcttttccga gaagccccgc caaaagcgcg ccggaaatga 1136581 ggcggatcac aagcataatg agcagataac ctggtgaata ggctgcatag ccagaaacaa 1136641 agagatcata gataaagctg gctactgaag accccatacc ggccagcata aggacaggga 1136701 gagagtatgc tttccagcgt gttgcaagaa atacagcctc agccccgagc ccttgaacaa 1136761 tgccaatgac gatgaccatc gggccagacg gatttcccag caggcactca acgagagcgg 1136821 caatgatttc agaaacgagc gccgcacccg gttttcgaat catgtacgcg gcgatcacag 1136881 aaacgataaa ccaaatgccg taaattggtt cataggcgat tggcccaaac atacctgcaa 1136941 gtacgtttcc gaaatgtgta aataataaat aaacaacggc aaatacgata ctgataacgg 1137001 acatgatgac aatttctttt actttccagc ttttcatgtt atccctgctt tctgtttttt 1137061 cttgatggac tgttagccga aagattcaca gtcatggtga tgtggtttgt ttgctgctca 1137121 gccatgcgga aaacggcctc caatgtgctg aatacgtcat gcgcatcccc gtcaagctcg 1137181 ctcgcgtaat ggacaccctg tacgaaagtg ccttgggctt ttgcaatgtc gacagcctcc 1137241 ataatcaatc ccatataatc cggctcattc attggataaa gggcaaattg gcacggcgct 1137301 tccgccttca agcctcggac agcatcttca ttgacacgct tatcaccttt ggaaagatat 1137361 gtatccccct gtgtgtcacc cgggcatcca atggaaaacg tgccgttcat gacgatgtgt 1137421 tgttcgctgt ttgctgcatg aaggtaaatg gcttttgcag catcgaatac atgatcaatc 1137481 gatccgcgta acaccgtgct gatatggtcg gttttcgtcc aaaccttgga tgtatctgtt 1137541 tttttcagcg cagacttgat cacactgata aaatcatccg tcatcggata taaagagaag 1137601 cgaaaaccgg cgattctgct tgtaccgcaa atatgctcca tttctccgac ctcctgtttt 1137661 tttggtaaaa taaaaaactg catatcctaa gggaatatgc agtcatagat cgattaagcg 1137721 cacaaaaaaa tacaccattc ggtcaacctg cacttcccca cgctggtatt atccagatcg 1137781 ggtcataagg gatcaaagcg cgtttcttcc gcgctttatc tcagccaaaa cagcacccct 1137841 agtgctttcc gtatacaatt ttttattttg acatcataat agatgataag aatcattttg 1137901 taaacaacga aatcattttt ttcatatagg gacgggagag gatggtcaaa tttggaaaaa 1137961 ggacacatat taattgtgga agatgaagaa aaaatcgcca gggttcttca gcttgaattg 1138021 gaatatgaag gatacagcgt cacgatcaaa cacaatggca cagaaggtct tgatgcggca 1138081 gcggaaggcg ggtattcctt ggtgcttctt gatgtcatgc ttccggggct tagcggactg 1138141 gaagtgctgc gccgcttgag aaaaacggat tcgcagacac cggtcatatt attaacggcg 1138201 cgagacagta ttcctgataa ggtaacaggt ctggacatcg gtgcaaatga ctatgtcacc 1138261 aagccgtttg aaatcgagga attgcttgcg agaatcaggg cggcgctgcg gcaaaatgga 1138321 acaaaaactg aagatatcgg cacctttctt acatatgacg atttgcgggt gaacgaaaaa 1138381 acccgtgaag tgagacgcgg agacaaagag gtggaattaa cgccgcggga atttgatctg 1138441 ctcgtctata tgctaaagca tccgcagcaa gtgctgacac gggagcaaat tctaagctca 1138501 gtatggggat ttgattatat cggtgataca aatgtcgtgg acgtctacat aagatacatc 1138561 agaaaaaaac tggactatcc ttacgaaaaa cagctgatcc atacgattcg cggggtcggc 1138621 tatgccatta aggggtaaac gatgaagctg aagaccaaga ttcatctata cacttcgata 1138681 tcactgttga ttttattaat tttggttcat accgcagtat atctcatttt ttcgtctgcg 1138741 ctgacatcaa aggatgcggc ccggcttgct gatgagacgg ataacattgc cgaagcgctg 1138801 cgtgccgctg aaacagaagg agtggctttg caggatatgc tgcaggccta tcttccggca 1138861 aatggcatgg tgcgtgtagt gaatggtgat caaaaagccg ttatgacgat cacaaaagaa 1138921 aaagcctata aagattttcc tctctctttt catagcggcg aaacggcaga tgtgaggaaa 1138981 cctgacggca agctgtttgc cgaggctgct gttccggtga tttggaccga tggacaagtc 1139041 gtgtctcttc agctggttga aagactggag aacacagaag agagtctgtt tctgctgaaa 1139101 atcatcttaa tcgctgcaag tgctgctgtc tgcattgctt ctttttttgc aggcagcttg 1139161 ctagcccgcc gaatcatcaa tccgatcaga cgattaatga tcacaatgaa agacatacag 1139221 cgagacaaag aatttaaaac gatttcttta gaaggacagt ccaacgatga attgtatcaa 1139281 atggggctga catttaatga aatggcaatg atgctgaagg agcactatga taaacagcag 1139341 caatttgttc aagatgcttc acacgaattg aaaaccccgc tcactattat agaaagctac 1139401 agcagcctga tgaagcggtg gggtgcaaaa aagccggagg tgcttgagga gtcgatagaa 1139461 gccattcact cagaagcggt gcatatgaaa aaactgacca atcagctttt ggcgctggcc 1139521 aaaagccatc aaggactcga ggttgatctg aaaacaatcg atctgattaa agcggcgcgc 1139581 gcggttatgc aaacgctcca gtccgtttat cagcgtgaca tattgcttga aacagataaa 1139641 gagagcctgc ttgtaaaggc agatgaagaa cgcatcaagc agctgttgac cattttgctt 1139701 gataatgcaa taaagtatag tgaaaagcct attgagatgt cagccggaac gaggaatgga 1139761 cggccatttc tatcagtgag ggatgaaggc atcggaatac ctgaggagca tatcccgcat 1139821 ttgttcgaac ggttctaccg ggcagatgag gcacgaaaca gaaaaacagg cggaacaggt 1139881 ttaggccttt ccattgccaa gcaaatcgct gatgagcatg gcattgagct gtctgtcaaa 1139941 agcaagccgg gacaaggaac agctgtcacc atgcaattca gcgaacagaa tgggggaggc 1140001 cgatgactaa aacaataaaa acagtatctt ttgctgcagc agccatttta gttgtcatca 1140061 tctgtacgtt tctcatcatt cggcaaaccc atgagaacgt attgtcaaag gagactgtcg 1140121 taaaaaaagt cgaagcctct tatgaaggca aggtcacgaa agcaacacaa tcaaaggata 1140181 aaaaaacata tgatataacc cttgaaaatc caaagggaac ttactttgta aaagcagacg 1140241 caatatcggc tgacattctt tcaatgaata gagtaaaagc agtgaatcca tctgccatga 1140301 cagaaaaaga agccgagcat ctcgcgcttg agcgggtgcc gggaacggtc aaaaaacaaa 1140361 cacggcaaag tcaagttgcc acttatacca tacaaaaaga agacgggaaa acatacgaag 1140421 tgaaggtaga catgcaggca aaaacagtct tgtctgccga tcaaatcagc agcaaagatc 1140481 aacaaaaaac gccgattacg aaaaaagaag ccaaaacaat tgcagagcga aaaacgggcg 1140541 gaacagcgga tgacgcagat ctcgaagaaa gtgagggcac tctcatcttt gaagtagacg 1140601 ttgatcttcc tgataataag gaagcgacag tgaaaatcaa tgcctacaca ggaaaggtag 1140661 ctaacattgt gtatgaagac tgacggtttc tcatcaaatt ctcatcttgc tctcgttttc 1140721 ctttcatgtt gagtatgtaa actgtactca tacaaaacaa aggagggctc acaaatgctc 1140781 aagaaaaaat ggatggtcgg tcttttagca gggtgcctag cggccggagg attcagctac 1140841 aacgcgtttg ccacagaaaa caatgaaaac agacaggctt cttctaagac ggatgcactc 1140901 actgaacaag aagcagaagc aattgctaaa acagttgttg acggcacagt agaagacatt 1140961 gacagagacc tttacaacgg caaagaagtc tatgaagtgg agattgaaaa agaaggtgaa 1141021 gactacgacg tttatgtaga tattcataca aaacaagcgc ttaatgaccc gttaaaggag 1141081 aaagcagaac aagtcgccat aaccaaagaa gaagctgaag aaattgcttt aaagcaaaca 1141141 ggtggaaccg taacagaaag taagcttgac gaagatgacg gtgcttacat ctatgaaatg 1141201 gaaatccaaa cgaagcaagg aactgagaca gaatttgaaa tttccgcaaa agatggacgc 1141261 attatcaaac aggagataga tgactaatca aaacccccgc tgcagcgggg gtttttcatg 1141321 ataagaaacc ttcttttgga caatctaagt agaaaaggag gcgaaacgca tggaaaagaa 1141381 agaggagcaa tacatcaatc aggctgaata tgtccctcat ccgacgaagg aaggagagta 1141441 tgccttattt cttcatgaaa cgtatcattt gctttctgaa gatgacgaga cacaaacaac 1141501 agaataaggg cttaggccct tgttttgttc cgtaattgtg atgtaagcgc atttattact 1141561 tttttgagtt gacatagctt gtttttttct gtaatctcag tgtgtcaatt caattaggaa 1141621 cttcgttagg tgaggctcct gtatggagat acgctgctgc ccaaaaatgt ccaaagacgc 1141681 caatgggtca acagaaatca tcgacataag gtgattttta atgcagctgg atgcttgtcc 1141741 tatgccatac agtgctaaag ctctacgatt gaaggcgccc gcacgctttt tttgccgtgc 1141801 ttctttcacc ttcaatcccg aaggcttttt ttatgccttt aaaacgaaac caatcaaagg 1141861 aggtgcggag tatggattct ccccattcga gtcaatctga agaagtaccc atatactatg 1141921 acagcaagac aattgattac acgatgagga gacgaactgc cgcaccttct ggcgaggccg 1141981 gcacgtctcc gtagaggagg tacgagtccc gatggttcaa aacatgacct atgacgaact 1142041 cattttacgc atcattattt tactgcgaga cgggaaaatc agggatttta gaagtgttat 1142101 tgatgagctt cagccctatg acatggcatt tatttttaaa gaaatgccgg aaaaacatcg 1142161 cgcccgctat ttatcttatt taactgtaga cgatatcact gatatgatcg gggagctgga 1142221 acgcgaattt cagcttgtcg tcttaaataa agtcggaaaa acaaaagcaa cactggcgat 1142281 gaacaaaatg gacaacgatg acctcgctca attgcttgaa gaaatggacg aagaactgaa 1142341 ggaacagctt ttatccagca tggaagcgtc agaatcaaaa gctgtacagc tcttgatgaa 1142401 ttacccggct gattcagcgg gacgcatgat gacaaaccgg tatgtgtgga tccctcagca 1142461 ttacacggta aaagacgcgg tcgtcaaact gaaaagcttc gctgaaatag ctgaatcgat 1142521 caactactta tatgttatta atgaaagcaa acagctggtt ggggttcttt cctaccgcga 1142581 tttgattctg ggtgaacctg aagaaaaggt gcaggattta atgtttaccc gcgtcatatc 1142641 agcagatgct cttcaggacc aggaagaagt tgcccgcctg atagaacgtt acgatttttt 1142701 ggcaataccg gttgtagaag aaaacaacgt gcttgtcggc attgtgacgg ttgatgatat 1142761 tatcgacgtt gttattcggg aagctgatga ggattacgaa aaatttgccg cttccggtaa 1142821 agacatcacc tttgacacaa aagcttacgt ggcggcatac cggcgtctgc catggctgat 1142881 tttactctta tttatcggac tgatttcagg aagcattatc agctattttg aagacgcgct 1142941 gaagcaggtt gtcgcgcttg cgtttttcat gccgatggtg tcagggatga caggaaatac 1143001 gggaacacaa tctcttgcgg ttgtcatcag aggtttgtct aaagaagaaa tgaacaaaaa 1143061 aacgattgtg cgcctgatct tccgggagtt cagaacaagc atttttatcg gagcggtttg 1143121 ttctgtgctg attgcgattg tttctatcat atggcagggg aatgcgcttt tgggatttgt 1143181 tgtcgcctct tcactgttct taaccttaat catcggcacg atgtcaggaa cgattatccc 1143241 tattattttg cacaaactga aagtagaccc ggcgattgct tctggaccgc tgattacaac 1143301 gttaaacgat attttatctt tattaatcta ctttggcatt gccactgcat tcattcactc 1143361 attataaacg taaaaagtcc gtctcaactg cgagccggac ttttattatt taacggtttt 1143421 tgtaccgaaa gtgagcatta agctgcccct ccagcatttt tttccgcact tgcggatcgt 1143481 tttttaacat ctgttctttt ttgcgcatat cctttaaaat ctctgccgtc tgtacgccgt 1143541 cttcacgctt attggcgata tccatcagcc gctccacatc ggcaaaggag tattttcttg 1143601 tcccccttga agaacgctgc gggtaaatga gctttcgttc ctcataatac ctgatctgtc 1143661 ttacggacaa tcctgtcaat tcactcacaa ttccgattga aatcactttt ttgtctttat 1143721 aagaatgatc ttctgtggtc atttttccac ccctggatgt cttttgataa tagtatataa 1143781 aaaacaaaga gaaaaaacct gacgcttgtc atattttcta acatcaaata gaagattttt 1143841 gaaaaaatac ggaagaaaaa ttaacaagaa taatgcgtaa cacccaagcg cgttttatcc 1143901 tttatgtaac gaatcaaacg aggaggaagg ataatcatgg aggaagaaaa agcagtctca 1143961 ctggcaaaag aaattataga gttggatatc aagcgtgatg aaatgctgga gacgtttatg 1144021 cagcttgccg gagaacaggc ttttcaatta ttaagatcgg ttcaaaacgg acaataccga 1144081 aaatcttcgt aaacataaat tctttacatt agattcatac cacgttcatt taaaaagagt 1144141 atcttttgta taggatacct caaaatgaag gaggacgcta tgagtaattt attgaaatcc 1144201 gctttagaaa aagaacgacg ccattattct gaaaaactct atcagatagg ggtttataat 1144261 aaagaggtca tgaacaaaat gacgatttct gagcttcgga aagaatacgc ttatttcttt 1144321 cgaagcatta caaatcataa aaattatcct tatacaagat aatgtataag gatttttttg 1144381 cttttagaag gaatttctcg aattatagcg aatacgtata gtaagggact gaactcttat 1144441 tatatgtaag ggttttcatt atttttttat aaaaatccta tatacgaggt agatatgatg 1144501 agattatcgt ttaacgaaga agaagttgag cgtgcgatga atttgtacag agtttttgca 1144561 agggctttca aaagtgtgtc cgaacatagt atccgtgata gcaaagagca cggttttaat 1144621 cccactgaat ttgctgtact ggaactcctg tacacaagag gcccgcaaaa attacagcaa 1144681 attgggtcga gacttctgct tgtaagcgga aacgtcacat atgttattga caaactagaa 1144741 agaaacgggt ttttagtaag ggagcaggac ccgaaagata aacgctctgt ttacgcacat 1144801 ttaactgaca agggaaatga gtatttggat aaaatttatc cgattcatgc actgcgtatt 1144861 gcgagagcgt tttcaggtct ttcgcctgat gaacaggacc agctgatcgt cctgctcaag 1144921 aaagcaggca tacacagcca gcatttgctg tttcgttaac tattctacac tctctatttc 1144981 aggagagtgt ttttttgttt ccatatgatt ctttttaaaa catctttaat cttcctatca 1145041 gacatttcgc caaggtatcc attgacgtgt tttttatact ccttcatctg ttcgttcgat 1145101 tgaaaaaatg ccgcgatata ctcttctgct ttctgcatgt cccagtttct catatctgtg 1145161 acgagtttcc tttcatgtag aaggtttaaa ttcatttcct cctgtcccgg cagtgcatga 1145221 taaataaata ccggaagccg tttctgtaag cattcactga tggtcacgcc tccgggttta 1145281 gtcatgatgc ctgtcgcctg ttcgtacaaa cggttcatct ctgctttgct gtgaaggtaa 1145341 ggaatcgcct caatcaaggg gtggtgtaaa cttttgacat aggagtagag cttttcgttt 1145401 ctgccgcata atattttgta taagatcttt ccgcctggcg acagttcctg cacccatttt 1145461 aaaatcccac cgacccccat actgccccct gtgatgatga tggtatatgg cgggtggtgc 1145521 tgcaaggtat ctgctgattc catttcaaaa ttttggtgaa ctggaatgcc ggtcaagtat 1145581 atgttgttct gatcgatacc ctctgatatt agctgcttct ttacttccgt gctcggaaca 1145641 aaatggtaat caatgttctt ccgtccccat aattgattca cgaaaaaatc agtgtataca 1145701 ttcacaaccg tcagattcgg atattcaggc tttagtcggt tcagcagata agaaggcagc 1145761 gcatgtgtgc agaaggcgat atcaggctgt ttttcttgga ggatgtgcct catttgctgt 1145821 gtgaacagcc attcgtacat gaaatagcgt ttgtcatgct gaaattctcc gcaggcgagg 1145881 agcctgtaaa tgccgctgta cgttttcggg aaatattgaa tccattttaa ataagccacg 1145941 gaggacaatt tttctaaccg cctatacgaa tgtgaaaaga tatcaatctt ttcagctgcc 1146001 agcccttgag actctaattc agcctgcaat gcatcagcca catgatgatg gccggtggaa 1146061 atgcttaaaa aaggaaaaat gagaatgttt ttcatgacag tcctcctaaa aaaatatggc 1146121 aactatattt tgaggagaac gttcacaaaa tataagggtg tttttgatca taaggaaggt 1146181 gaaaagatga aaacttgttt cctttccata tggagagtgg ttgatccgat ttatttcttt 1146241 ttttcaaggc taagcttgat tgacaacgat caaaaaagcg tttttcgagt caggctgacg 1146301 aagtacaaag gacatcatgt cgtgcttagc gacggaacgc atataagaaa aaatgatgtg 1146361 ctcgttaaaa tccacctgca taacataaag ctgatcaggg agctgcaaag cattgagagc 1146421 gcagtcagaa agggaatcat tatttatcag aaagtatatc aatcgatgcc gcttcttctt 1146481 gactatatca acaatcataa aaaaagcgag aaaatcaaag gaatcattgg gattacaatg 1146541 cttgacaaag gtgtggaaag gctcggcttt gatgtgatca ccccggtgaa ccctttttac 1146601 agatgcttta aaaaagtgtc tcatgtgccg attttatatt tgacttcaaa gcctgtgagc 1146661 ttgcggcatt taccgaattc atcctatttg tttatctcaa aagaaaagct gcagaaaacc 1146721 tatcaaaaaa aagactgatg cctcggtcag cacagtcttt tttgattaaa tctgatgaaa 1146781 tgtcacttca gggcggcttc cgacacggat atttacgccg gtttgtccca agccctcgct 1146841 gatataaaat ggtttatcgt gatgataatg aaggccttta atcatgttca ttcgcacgag 1146901 ctttcccatt ttcaccaaat gatacggttt tggccagtga atttgcccgc cgtgaaaatg 1146961 ccctgacagc aggtaatcat aatgaacatc tttcatatcc agaataatat ttgggtcatg 1147021 tgttaagaca agatgatagc cattttccag actttgataa gagccggtga tattactccg 1147081 attcgtactg taatcatcaa tgccgataat attgactggt cctgcagccg tctcgattcg 1147141 aacatgttca ttttgcagcg tgatacagcc gttttcctct aaaactcgct tcaatctctg 1147201 aaagtcctct tctttcaata cataatcgtg gttaccgaac accgcgtaca ttccatatgc 1147261 aggctttagc ttttgcaagg cgttcaagta acctgccagt ttcggaatat tacgtttccg 1147321 atcaagaaaa tccccggtaa gagcaatgat gtccacaggc tgatcttttg ttaaatgata 1147381 cagctcctca ggtgagactg aaatgttttc caagtgaaga tcagataaat gaaggatatt 1147441 taattttttt ctggctggaa ggccgtcttt ttggtcgatt gaaatggtgt tgactttcac 1147501 atcttttgta ttgcggttcg ctttatatag aaatggcaca aatacgagta tggccaatga 1147561 aagtaagatt gtaaacaaaa tatatcccct cccttctatc agtatagtaa gtgatcaagc 1147621 cctatggata gcgggaatta atgggtagag acaggttgaa aaacggattg tcatatgatg 1147681 aatgatttgg aagggaaaag ggataataaa ttttgacaca tgaggcagaa catgccgacg 1147741 gagtcagaat aacaaatgga tgtgtaagca atgttacgat tgatgagaca acaaaaaaaa 1147801 gaaacatatt atctctggat cgcattattt cttcttttat tgtatgtatc cccgcttttt 1147861 attttaaagg aagatgccca tatccgggtc cacgataatt tagattccaa catcgcttgg 1147921 tacaaggttc tggccgatag cggagaaatc gtcggcaagg ttgacgctgc cattccgcaa 1147981 atcattaacg ggctgccccg ggatgccttt ggcaccgagt ggagcggaat tgtttggctc 1148041 catgctttct tttcttccat gaccgcctat gcaataagcc agacggttac aagagttgtc 1148101 gctttttttg gaatgtatgt gctgctgaag aaacatataa tcccggaacc aaaagcggct 1148161 ttcatccgaa ttggcgtatc gcttgcattt gccttaacac cgttctggcc ttcgggaatg 1148221 ctgagtacgc ttgggtaccc tttggcactg tgggcttttt taaatatccg aaaaggggat 1148281 atctcatgga gagagtggct gacgctgggc ttgctccctc tatactcaag ctttgttcta 1148341 ggcttcttct ttttcctggc agggatggcg tgtttttggc tgtatgatgc cattacaaaa 1148401 agaagatgga atttgatgtt cttaggcagt attgcattta tgacgagtat ctatcttttc 1148461 gttgaatatc ggcttgtcta ttcgatgctg tttgagcacg caccgatgca tcgtatcgaa 1148521 tttatctcat ctaggcatga cgtttggcat tctcttcgac tatccataaa aaactttgtc 1148581 tatggccata atcatgtgat gaccgttcat accgttgtca tccttccgat cctgatggtc 1148641 gtatttgctg ctctgctgtt caaacgaaat cggacaaagc cagaaaatgt ttatctgttt 1148701 ttatgtgtgc ttaattacgg gttgtcatta tggtatgcgt tttggttcaa caaaatttgg 1148761 gctgttccaa agcagaaatt tgctttttta gcagaattta attttgcccg ttttcatttt 1148821 cttcggccgc ttgttatata cgtgagcttt gcgcttgctt tatatctcat ttggcggatg 1148881 gggaaaggat ggaaatggct tgtgtacgcc gcagtcgctg cacagctgat ggtgttggcg 1148941 ccttttaatg aagaatatac gtatggtgtt cattacaacg cgccgacatt cagggagttt 1149001 tatgcatcag agcaattcaa agagattaag gaatatatcg gacgtccgca agattcgtat 1149061 agggtggcga gcatcggact gcatccgtct atcgcccaat ataacgggtt ttatacgtta 1149121 gatacgtata acaatctgta tccgctctca tataaatatg aatttagaaa aatcatcgaa 1149181 aaagagctgg aaaaaaattc tcggctgaaa caatactttg atgaatgggg cagccgctgc 1149241 tacctttttg tcgatgaact cggtaaacga tatgatttca aaaagaactc gaagaaaacg 1149301 atcaacaacc ttcaattaaa tacagatgta tttaaaaaaa tgggtggacg gtacattttt 1149361 tcttcagttc cgatcatgaa tgctgaacaa aaccatctcg cgctcgtaaa gacgtttgac 1149421 cataaagatt ccgcctggcg catttattta tatgaaacaa gataaggagg atatcgattg 1149481 aaacagtcac agccagtatt aaccatcgtc gtcccgtgtt tcaatgaaga ggaagtgttt 1149541 caagaaacaa gccatcagct gacagaggtt gtagatgatt taattgaaga aaaattaatt 1149601 gctgaagaca gtaaaattct gtttgtcgat gatggcagca aagaccgcac ttgggctttg 1149661 attgctatgg agagcataag aaacaagaag gttaccggct taaaattagc ctgcaatgtc 1149721 ggccaccaaa aagcgctttt agccggattg cataaagcga agaataggtc agactgcgtc 1149781 atttcgatcg atgctgatct tcaggacgac atctctgtga tccgggattt tatgctgaaa 1149841 tatcatgagg gctgcgagat cgtttacggt gtacgccgga gcagaaaaac cgataccttt 1149901 ttcaagcgca cgaccgcgtt agggttttat cgtctcatga ataaacttgg gattaaatta 1149961 atttataatc atgctgattt tcgtttaatg aataaaaggt cccttgaaga gcttgagcgt 1150021 tatccggaag cgaatctgtt tttaagaggt attgtcccca tgatcggctt taaatcggcc 1150081 gaagttttgt atgaccgcaa ggaacgcttt gccggcaaaa cgaaatatcc gctgaaaaag 1150141 atgctatcct tcgcttttaa cgggattact tcattcagtg tcgcaccaat tcgattcttt 1150201 acgcttttag ggtttgtttt gtttttcctc agcgctgtgg cagggattgg cgcgtttatt 1150261 caaaagctgc tcggccatac gaatgcaggc tgggcgtctc ttatcatatc catttggttt 1150321 ttgggcgggc tgcaattgat gggaattgga atcatcggag agtatattgg aacgattttt 1150381 tctgaagtga aaagacggcc gaaatacgcg attgatattg atttgtataa tgaacagctg 1150441 agcccgcttc agcgccagga aaaagagcgg ttagaaaaaa agtacagtta aacacggaaa 1150501 gagctgactt cattagtcag ctctttttct tcaactgatg caatatagcg ctaagcggtt 1150561 cgtcttgcgg gttgcggtaa aaatcaaaaa atgggcagcc ctgcttctta attcgatcga 1150621 tgaccgtatc aattgtaaac agagcgggtg ttaaagatga ttgcacctca tgccagtaga 1150681 gcggggctgc aacagtccca agctcatttc ctctcgttga atagggacag ataatcgttt 1150741 ttccttctgc atgctgcaaa taatcaagat acaatttgca gtgtctgttt ttaatcaagc 1150801 gttcagtggt aaagagctcg ggaaatgcat tggtgcagta ctctgcgatc agctgcgtaa 1150861 attggcgtgt ttcttcatac gtaaatgcct cgggagacaa gggaatataa agctggatgc 1150921 ctttgttgcc ggacagcttc gggtacgatg tgatgccaaa ggaatccaac agccgcttca 1150981 gttcatttgc ggcctgcacg gccataagaa agtcatctcg cgaaggcggg tctaaatcaa 1151041 tgacaatctc agccggacgc ctgcttttaa tggtttgaaa aggaacgtga aactccaaag 1151101 caagctggtt gcaaagccat agcaatgtag acatatcctc acagacaata tgttcatggc 1151161 ttccatcata gaaagactga acaaaatccg gcgcatagtc cggcttgttt ttttggaaaa 1151221 atgattcgct cctagatcca tgcggatagc ggatgacggt gacagcccgg tttttcagaa 1151281 atgggagcag gtagtcactg acttcaatca tatactgaat aaaatcttct tttgtttttt 1151341 tattcttttc aaatatgatt ttatccaggc ttgtgaactg gagctttggg tgaaccggtt 1151401 tggagtgtcg tatgacttgc gcatacgtgc attcggtcca gtccatttgg aattcgaaac 1151461 cgataaacga tacctctctt aatgtgcctt ggagaattgt taagtattga acagctgcac 1151521 aaatcgaagg ttcaagcgta aattcgcctg agggtgtttg atgtccgtgc tgttccataa 1151581 tctcgcgtat agcgcttttt tcctcatcac gcattccgtg cgagacagag gcaatcggtg 1151641 tcattattcc gttttttaac accgataccg tcagaaaccc gttgttaggg ttgaaccctg 1151701 ttatgcaaac ataagcttgt ttaaagtttt tatatttgag ccaatcggac gaccgcttct 1151761 tttcaagcca tttgctgttt gttttcttcg ctacaattcc ttctccgtca tattttatta 1151821 ccatctccca gagttgatca aaatgatcat aacagggaat ggattgaatg gtttcttttg 1151881 cgtaaggatc tggagatgca ggaagctttg ctgcggatat gagttcacgc agcgattttt 1151941 tgcggtccaa atacgaaaga agcgttacat cttctccgct tcgctctaac aaatcaaagg 1152001 cgagaaagca gcacggccgc gcgtttgccg attcctgaat cttgtctggc cttttcaaac 1152061 gcccccgcac ttgaaggtgt tcaaaatctg cacgacaggg attcaccaaa catacgattt 1152121 caccgtcaag tgtcagcgga agctcttttt ctaggtgctg aaaggcagtt ttggcgaatt 1152181 gtgtgatttc agggaaggtg ctgctgagct ccacaccatt tctgctggtt aaggtcacac 1152241 ctgaagaatg gatgcggaga atacagcggt acccatcata ttttacttcg taacgccatt 1152301 ctgctccgat tggcggtgac gaagttaaga ccggctgcat ggtaaacgcc atgcgctatg 1152361 atgtgccgga ggcttttttt ctagttgttt tttgtttttt atctccggct cctttcggtt 1152421 cagcggcttg tgcaggtgcg gcagccggtg tctcccggtt cggccttctg gttctgtcga 1152481 tgctggcttg cagagcgctt accaggtcaa tgacatcttc acgaggtggc gctttatcag 1152541 gagtgacagc cgtttcttta ttttctagct tgtcgttgac tctttgcagc agcgcctgtc 1152601 ggtacgtgtc ttcatatttc tcaggctcaa acttagcagt cagttcatct attaatgtga 1152661 tagcagtttg cagttcctta tcgtttacat tcgattgatc aggtacacct gggacttgag 1152721 cggcgcttct gacctcatcg ggataatgga tagactccat gacgatacaa ttttcataaa 1152781 cgcggagaat cgccagctgc tgctttgacc tgattgtcat attggcgata ccgatctttc 1152841 cggttgagcg cagcgcctca cgcagcaggg tataggcctt cgtcccatta tccccggggc 1152901 cgacaaagta ggagcggtta aaataaatcg gatcaatttc ctgaagctga acaaagtcaa 1152961 caatctcaac tgctttctcc tcatgctcct gttttaagct ttttaaatct tcgtctgtca 1153021 gcactacata ttttcctttt acatattcat atcccttcac aatttcatca ggactaagag 1153081 ttttttcgca atttgtgcaa actttctcgt atttgattgg tgcgtgatcc tctttatgga 1153141 ggctgcgcag tttaatatct ttatcttctg tggccgcata tagcttgatg gggatgttta 1153201 ctaatccgaa gctgatcgat cccttccaca ttgtatgcat atcgataaac cccttttttt 1153261 ctttagtgtg aagagaagga gtacgattca tgtgtagtaa cttatgggtg aaaaaaagcc 1153321 ggcgctgtta ttgcgacggc tgttcaataa tgaattgttc gaattgttcc ggaggtattg 1153381 gcctgctgaa aaagaagccc tgcaaatggt cgcagccttt ttcaaaaaga agctgctttt 1153441 gagctgcatt ttccacacct tcggcaatca cctgcaaaga cagctgatgc cccatggcaa 1153501 taatagctcc ggtaatttgc tctgatttag gatgggtctg aatatcgtca ataaatgatt 1153561 tgtcaatctt cagcctgtga atcgggaagt ccttcaaata gctaagagag ctgtgaccag 1153621 taccgaaatc gtcaatactg attctgattc ctaattctgt tagggatgac aaaacctttt 1153681 tggagtgatt gagattgtcc attgtcatgc tttccgtcac ctccacttca agaagctgcg 1153741 gaggaagctg gtacttatta agcgtatcct tgatgagggg aatcagatct ttagattgaa 1153801 actgtctggc ggaaatatta atggcgacag aaagatcata gcctttgtca tgccaaatcc 1153861 ttgcctgctt gcatgcttca tctataatcc actttccgat atcaataata agtcccgttt 1153921 cttctgcaac accgatgaat tctccgggcg gacgcagttg cccgtctggt gtcacaaggc 1153981 gtatcagtgc ttctgctcct gtcatttttt gttttttcac actgaattgc ggctgataat 1154041 gcaagacaaa tctatcgttt tcgattgctt ctctgagtac catctcttgg ttaagcttaa 1154101 cggtttcttt gttgccgatt gaaaaagaat agtatctgta tttgcttttg tttcgttctt 1154161 tagccgcata catcgccata tcagcctttt tcatcaattc aaggccatcc gtcccgtctt 1154221 ttggagatat cgcaatcccg atactgacag atgtgacaag ggtgtgatct tgaattttga 1154281 aaggtttttt gaatttttgg ataatttttc ttgctaaaac atctgcttcg cctgttcctg 1154341 tattggcgtc tgttaatata ataataaatt catcaccgcc aagacgggcg ataaatccgt 1154401 tatcagggac tacagatgac aggcgtttag ctgcaaactg aagcaattga tcaccgacat 1154461 tatgccctaa tgcatcgtta atcactttaa accggtttaa gtcaagaaag aatacaacag 1154521 tgttataatg caaggaatgc tcgcgattca gcacctttgt tagatgagag atggcatgcc 1154581 ttctgttagg taagtctgta agcgaatcat aatgagccat tctatggatt tctttttctg 1154641 ctttgtactg cttcgtcatg tctttacaaa tgacataaat gctgtctagt tcctgattga 1154701 cctcaacagg tataagcgta atatttaagt gaaactggcc tttttcagtg ataagatcgc 1154761 tatcgctgtt catcgcttgt ttatcttttt taacttgctc aaaaaggcgc ttaaccttca 1154821 gtgatgtgta attcctccag tcatgcatgc tgaagccaaa tttgctgatc atttcctcac 1154881 cagcgtgatt ggaagatatt atgtctcctt ctaatgataa aataaaaatt gcatcaatat 1154941 tgtggacgat taaagactga aatcgctgtt cgttatcctt tatgcgttcg ctctgtttaa 1155001 taaactttcg atctgcatgg gaactgaata acaataacgt ttggatacaa aaaataatta 1155061 aagtaacaaa aattgaccaa tgaaacgttt gcacctccat atggcttccg ggcggagcca 1155121 tgtccttatg gaaagttgcc gcaagcatcc ctgtgtagtg catgcccgaa atcccaatgc 1155181 ccattacaat tgaactgacg cctttataga atataagatg ctcagaatgt ttttttacgg 1155241 ccaagtcaaa gaatattttt aacgagacga aagaggctgc aatcgcaatg ataattgaaa 1155301 ctgtaaataa aataggttcg taaataatca ttacccggga aatggcagac attccgatat 1155361 agtgcataga agcaatagat gcgccaagca caactgatcc ggtaagcagt ctgtaatatg 1155421 taagaatgtg ccggctgaca aaatataatg acacaaatga tcccgaaaca gatgcgccaa 1155481 tggctgccat taaaggcatg aattcatatt ccatcggcat ttccatatgg acggccatca 1155541 tccctacaaa atgcattgac caaataccga atcccataat aagtgagccg ccgatcagcc 1155601 aaattttact ttttaagcct gtattgatgg tgactttcct tgaaagttca agggaaatat 1155661 acgaggcggt acaggcaatt agaatagata aacatatgag agtcgtatta tatgtaacgt 1155721 gtatttccaa atggagattc cccccgtatc gtgtgttcca gtcttgttga ctctctttat 1155781 tatcggctgc ttaaccgcag agtttcagcc ttcaaaacga tagaaatacg agggagatct 1155841 atttttagtt caactgaccg tgaaaaatgt gttaaaatca tcttgatgtt ttccgaaaag 1155901 agaaaaatgt atgatacata aacatgaaac aagggagttg gtggctatcg aagagctggt 1155961 tatgtcatgg attgaagcat ttaaaagctt atcttatttt ggaatatttc tagcgctcag 1156021 cattgagttt attccggccg aagtcgtctt gccgcttgcg ggctattggg tatctaaagg 1156081 cgatatgaca cttgctggcg ttgttttggc aggatcgctt ggaggagtgg ccggtccgct 1156141 tacgctgtat tggataggcc ggtacggagg aaggccgttt cttgaacgtt ttgggaagta 1156201 tctctttatt aaacctgaag cgcttgataa gtcagataat tttttcaaaa aacatggggg 1156261 ctttgtcgcc ttcagcggcc gtttcttgcc tggtatcagg acattgattt ccataccgtg 1156321 cggaattgca aaaatgaatg tttgggtgtt ttcgctttat acattcattg ctatgcttcc 1156381 gattacattt gtatatgttt atctcggtgt gaagctcggt gaaaattgga aggcagtcgg 1156441 ctctattctt gatcaatata tgcttccgat cgggatagcg attttggcgc tgttcctgct 1156501 ctacttactg atgaaaaaga ggaagaaacg cacgcactcc gaacaattat ctgtattttt 1156561 gaaaaataaa cgttgacaaa tcactgcgct gcgcatatta ttgacgtata aaatcatatt 1156621 tcttgaaatc ccaaagggga gtagcgtccg gaatgtattc cggaaacaaa gtcgtcattt 1156681 catggattgt atccatcggc tttgttggca tgcctgaatt catgtctagc aagacctttg 1156741 ccttatgtcg gcaaaggtct tttttgcatg gtccggccgg cataagatcg gatgaagaga 1156801 aagaaaacaa cttttttggg agggtatcat ttatggatgc agcattatta ttagagtatg 1156861 gttgggttct tctcgtcttg atcgggctgg aagggatttt agccgccgat aacgcgctgg 1156921 ttatggcggt aatggtaaaa catttgccgg aggaaaaaag aaaaaaagcg ttattttatg 1156981 gattggcagg ggcttttgtt ctgcgatttg gctctttatt tgcaatttct ttcttggtca 1157041 acgtatggca ggttcaagcg attggcgcga tctatttgct gtatatctca gcaagccact 1157101 tattgaaaag atatgtattt aagaaagaag acacacataa agagacgaag caaagcggtt 1157161 tttggccgac tgttttaaaa gttgaactgg cagatatcgc gtttgctgtt gattccatct 1157221 tagcagcagt agcgctggcg gttacacttc ctgggacatc actcccgaag atcggcggac 1157281 ttgacggagg acaatttctc gtcattttgg ccggcggtat catcggactg gtgatcatgc 1157341 ggtttgcggc ttccatgttt gtgaagttat taaaggaacg tccaagccta gaaacagcag 1157401 cctttgtgat tgtcggctgg gtcggagtga agcttgcttt atatacgctt gcccatcgcg 1157461 acatagcggt tgtttctgag cactttatcc attctggaac atggaagctg atattctggg 1157521 gtgtcttagc agcaatcgcg gtttgcggct ggtttatgtc aggtgggaaa aaacagccgg 1157581 agggtgcaca aaacgaacaa aaaaacagca cccgtgaacg ggcgtaatct gaaagactct 1157641 gcttaaaagc agagtctttt tgtgtttgaa gcgttttcat aagcgaaata aaataacatt 1157701 tttataacat ctttgttaca aaaaacacgc ataaaacccc cttaattctt tagaaaggca 1157761 cgaaatcatg tatagaacgt cagaatggtt tgtcataatt gagacattgg aaatcaatat 1157821 ttctttttct cctttgcgaa tccctatcaa attagctatc attaatgagt agttataggg 1157881 aggaactgag gtgaaaccag tgcttagcct tttgtttaaa ttgggaaaaa agaagcaaac 1157941 acttgaaaaa gctgttgaga gtatacaaaa aggcaataaa gatctgcaaa atgaattaat 1158001 acagcaatat aagccattta tcgcaaagac ggtttcatcc gtttgtaaac gatatataga 1158061 tgaaaaagac gatgagttca gtattggact gatcgcgttt aatgaagcta tagaaaaata 1158121 ttcacctgaa aaaggaaatt ctctgctcgc atttgctgag cttattataa aaagaaaagt 1158181 cattgattac attagaaaag aagccagaag cgcacaaaat ataaatatcg atttacagga 1158241 aggagacgat caggagtcat cacaaagcct gattgaagcc gagctttcca ttgatgaata 1158301 ccgccgtcag attgaacagg agcagaggcg ggaggaaatc ctctattttc aaaagcagct 1158361 caaggattat ggtttatcgt ttaaagaact gcttgaaaat tctccaaaac acacggatgc 1158421 aaggcaaaac gccataaagg tggcaatgac gcttgttgaa catgaagaat tggccgctat 1158481 cctgtataca aagaagcagc ttccggtcaa acagcttgaa cagcttgtct ctgtaagccg 1158541 aaaaacgatt gagagaaaca gaaaatatat tattgcgatg tgtattatca ttacgggtga 1158601 ttatatttat ttaaaagatt atcttaaagg ggtgctgcac tcatgagaag agggattata 1158661 gtagagaaaa ataaaaaatt cgtcacgttg ctgacccctg acggacaatt tttaaaagcc 1158721 aaaaatgatc gacacagcta tgaaatcgga gaagaaatca tgcttccgag tgaaacacgc 1158781 atgggcagaa gggccagctt ttttgatttt tttaaactgc gccctttcaa aatggggatt 1158841 tttacgatga ctgctattat gctctttatt tttatagttc tccccgtttt ttctaataat 1158901 aaggcctatg cgtatatgac aatcgatatc aatccaagcg tcgaaatggc gttaaacagc 1158961 gattatgaag tgattgaact gacgcctcta aacgatgagg gacagaaagt cgtgaatgat 1159021 atagatgatt gggagaagac tgattttaaa aaggtgattg acgatattat aaccgactgc 1159081 agtgaacacg ggtatgtaaa aaaatcgaaa gaaatattga tttccactgt ttatgaaaac 1159141 acagaagaca atacatataa aaaggctgtg aaaaaacagc tgaatgatgt gactgaaaaa 1159201 tataaaacga cataccgcat ggaatctctc gagtcagata tgcaaacgag ggaaaaagcg 1159261 aagaaagaag gcgtctcaac aggcagctac atcaaatcaa atgaaaagaa tgacaataaa 1159321 gatataaaag atgactccag caaaccatcc ggggaagagg atcaaaagag tgatgaaaat 1159381 gaggatgaaa acaccgatca aactgacacc caggacagca agcaaggaga taatgaacag 1159441 ctgaatgatg cggattccgg agaccagaaa gaagagaaag cggatgacca gattgatgat 1159501 agtgacaaag ataaaaaaat aaaggaatca gatgaaaaca caaataccga aaaagatggg 1159561 gaccatgagc aaaccccaat acaagatcct caagataaag gaaatgaaaa taacggcgct 1159621 gacaagggcc aaagccaata tcacagggac tggaacaatg gtgaacaagg caagaaccgt 1159681 tcttcgtcca gaagggataa cgcttcagac cgacgtaatc caaacggcta cagcagtgat 1159741 aatcattcag ctaaaaatga agattcgccg agtgcccccg gcgaataaag acctgaattt 1159801 atttagttgt gccatttaat tgtgattgtg cttgctgtac cagccgcttt gtcatttctc 1159861 cgcctacaga gccgttagcg cgtgcgactg tatcagaacc aaggttcaca ccgaattctt 1159921 gagccacttc gagtttaaat tggtctagtg cctgctccac ccctggaaca acgagtttat 1159981 ttctgctcgc catctttttc atctcctttt tcgataaaga aattcttaac gcgtatttag 1160041 tttgaaatat acggggttta tttatgctgg caattgttgt ggagaaaaat aaaaccccgg 1160101 cctctgagcc ggggtggcgc agactataga atgtctgctg tcattttatg tgcggttgcc 1160161 tgaatatgga atgtcaaaat ggagaggact gtaatggcga taatctgtct gattttaagc 1160221 cattggctgt cattcagttc ttcaaaacgg tgacggagac gctctgtctc ctgttcggcg 1160281 atctcctgca gatttgattc tttcatagaa ggagtatctt ggtgatggat ggcatcaagc 1160341 acatatgcgc agctttcata ataagcaatc gggctgatga catcatcaga tctgtctgag 1160401 attgtgttaa aggccacttt taaaatagcc cgtatgtgtt caaagtcata aatggatttt 1160461 aaatcacgta caattaaaag aataactgcc tgttcaattg agtatttttt gcccagctca 1160521 gggtgtccga tcagatcttt gatatcacgc tttacccagt tttgaatcgc ggttgacttt 1160581 aacgaagtca gctcgcataa gttgccaagc tctacgattt catttgtaga cagaccgtat 1160641 tcttttttct gtttttttcg ttcgtatctt gtaagaaatt caggaatttc tagatgattg 1160701 gctgcttttt ctgctgacat gttcgctgat tggacgagaa tgtcgagcgg gctatgttct 1160761 ccttgtcctt ttagggaata gagcagccgc accatatcgg ttcgagagag tttaaaaatg 1160821 ttcattgttc acctctttaa acaatttgac gcggatatag gtctatgtat aagttcaaaa 1160881 ttcaagcgtc agcaaattac attaacatca tacgtcgaat tccttgcatt ttcaaatgga 1160941 tgttttataa tttaaatata cgggttcttt tgaacttaaa ataacggagg ttgttatggc 1161001 gaaaagaatt tttctgttta ttctaacgaa tattttggtg cttacaacaa tcgggatcgt 1161061 tttgtctgtt ttaagctctg ttacaggagt cgggacgtac tttacagctg atggcggtat 1161121 cgatccaatg gcgcttcttg tgttcagttt agtcgttgga tttgtcggtt cctttacgtc 1161181 tcttgcgata tccagatgga tggcaaagac gatgatgggc gtcagagtgc tgaatccgaa 1161241 aaaacactcg ctcagctatg aggaacagca attggttgat cgtgttcaca gattaagccg 1161301 ctctgccggt ttaacgaaaa tgccggaagt cgggatttac cgttcacctg aagtaaacgc 1161361 gtttgcgact ggaccgtcaa aacgccgttc acttgtcgca gtatcgtcag ggctgctgga 1161421 gcagatggat gacgcagcag ttgaaggtgt gcttgcccac gaggtcgcgc atatcacaaa 1161481 tggtgatatg gtaacaatga cgcttttaca aggtatcgtt aatacctttg tcgtcttttt 1161541 atcgcgtatc gccgcttgga tagcaagccg ttttgtcaaa gaagatctag cgccgatcgt 1161601 tcattttatt gcaatgatta tttttcagat tgtcttttcg atacttggca gcctggttgt 1161661 gtttgcgtat tcacgccatc gtgaattcca tgctgacagg ggaggagcgg atcttgccgg 1161721 caaggacaag atgattcatg cgctgcggac gcttaaaagc tattcttccc ggattttgga 1161781 agacgatcag acagctgtcc aaacgttaaa gattaatggc aagaagcgct cttcactttt 1161841 ctctactcat cctgatttag atgagcgaat cagacggctg gaagctaaat aatacaaaca 1161901 cattgttcct ctgagagaat tctcagaggt tttttatttt atccattgac taaaatcata 1161961 aaaaaataag caagttaaga aaatgtttcg taaaagcctt taaaaatgga cctaatatct 1162021 ttagaataat taccgtactt aaaaagagag gcagaaggat tttacatgag attaaagttt 1162081 ggaaaattga tacaggcctt gtcaccggcc cagctgatcg cattatatta ttttcttgca 1162141 gttactgtgg ccgttatatt gctgagtttg ccggcggccc ataaaccggg ggcggattgg 1162201 acgtttattg atgcgctttt tacagctgtc agttcagtca gtgtaacggg gctgacagtt 1162261 gttgatacag ctgatacatt cagcacaata gggattttta tattagcatt tgttctgcaa 1162321 tttggcggaa tcggaattat gacgctcgga acgttcattt ggctgatcat gggaaaacga 1162381 atcgggctga aagaacggaa gctgattatg gttgatcaaa accaatccca gttttcagga 1162441 attgtcaatc tgatgaagca ggtactgttt ctgatcttgt ggattgaatt ttttggcggg 1162501 ctgatactcg gcacatattt cttaacctac tatgactcct atcaggaagc ctatttacac 1162561 ggattttttg ccagtatcag tgcaacgaca aacggcggat ttgatattac cggtaattcg 1162621 atgattccat ttcgccacga ttactttgtg cagtttatta caatgctttt aattatattt 1162681 ggagcgattg gatttcccgt gcttgttgaa gtaaaggatt tcctgttttc aaagcatcgg 1162741 cgttatccat ttacgctttt tacaaagatc acgacgatta cgttcggctc acttgtcttg 1162801 tttggagcca ttggcatctt tgccctggaa gcaaaccatg cgttcgcagg aaaatcatgg 1162861 catgatattt tgtttttgtc cctgtttcaa tcaacggcaa cccgaagcgg ggggctggca 1162921 acaatcgata tcagccaatt atcagattcc acactctttt ttatttgtgc gctgatgttt 1162981 attggagcgt cgccaagctc agtcggggga ggcataagga caacgacttt tgctttgaac 1163041 cttcttgcgc tgtttcattt tgcccgcggc aataaggccg taaaggtatt caaacgggag 1163101 cttcaccctg ctgacttgat gaagtcgctt gttgtcacga tgatggcgat cctgctcgtt 1163161 tttggcgcga cactcattct gaccattaca gaaaaacatt ccctgctgga gcttttgttt 1163221 gaagtgtgct cggcattcgg tacaaccggc ctatcgcttg gaattacggc agatttgagc 1163281 agtgttggaa aatgcgtcat tatgattgtc atgtttatcg ggcgaatcgg catcttgacc 1163341 ttcctgtatc tgatcggaag aaaggaaatt gaagcgaatt atcactatcc gaaggaaaga 1163401 gtgattatcg gataggcaaa acaccgcata ttttgcggtg ttttttgatt accaaaaaaa 1163461 agatgtgtgc ctcctgttca gttggagaac ctaactccga caggtgcaat ttacgctcct 1163521 gcatcttaaa atgtctgaaa attggcgagg aggattcgta tgaagcgtaa agctgaagtg 1163581 aatgaagcca ttaaaaataa caatacacct accgagagca tggaccccaa ttcatataag 1163641 acacaatatc atgacgaccc caattttaga ggggcaaacc gcaattccaa acagggccag 1163701 cagggaggca tgtaattgtg aagaaaaacc gtcatagcag agacatgcaa aatcataaaa 1163761 agcctatgaa taaaaaggtg ctggaggaag aattctcaag tgaactcggg gattacaatg 1163821 ccggaaagat catcgaaacg ctggaagtca ccaagcctga aaagaaaaaa gaaaaaaaca 1163881 aaaaacaaca ataaaaaaga cctcttaggc ggcgtcccgc ttaagaggtg ctttttctat 1163941 tttaaataag catttttgcc cgttcctctg acaaattgca ataagcttgt catcctcagc 1164001 tcaatgaatg gctgagcgac tgtcttaaca aagttgctgg agaggactga tgtcagggct 1164061 gctgttaaaa gcaagaggat cactaagctt tgatagtcag taagccaatc ctcaagcccg 1164121 acctgccgta atgtcttaat aataaacccg tgaagcagat acacgtaaaa tgtccgggtt 1164181 ccccatttgg taaagaaata ccgtttttgc ggaacgagcg ctaaaaagct gaaggttgcc 1164241 ccaaaggcga gtacatacca gccgattcgg gatagtccgc ttaccagggt aacgtctcca 1164301 aatgaagaat acggttttga accaaacaga aaagaatagt caaaatcgat gccccagcag 1164361 atgacgaata ctgcggcaag cactccgagc gcaatttgtt tgccgcgttt tgatctcaat 1164421 aaatcaaaat gatgtttatt taaataaaaa ccgacaagga acatcggtaa gaatacgaat 1164481 gtccgtgaca agctcagcgt gctgctgaca aagtccagat aaccgatcag cacggcgatt 1164541 ccgcagctga caaacagcgc ccactgcttt gaaagctttg aaaaaggata taggagcagg 1164601 ttccaaaaga ataagcttac aagaaaccat aacgaccatt gcggatcaat cgggttcaca 1164661 tttgccatgc tttcatcttg cataatgtaa taaaagacgg aataaataat ttggaaaatc 1164721 aaatacggaa taatcagctt gaccgccagc ttttttacat atcccgcccg tttaaagcct 1164781 ttcgcgaaat aaccggatac aagaataaat gcaggcatat ggaatgtgta aatgaacttg 1164841 tagaggtaga gcataaaatg attatcatta ataaaggaac gaaggatatg accgaataca 1164901 acaaggaata tcaataaaaa ttttgcgtta tcgaaataac tgtcccgcga tttactcata 1164961 gcatcacctt ctctttcatc agtcactaag agattattcc ctgctggtac atattttaaa 1165021 ataaaagatg aaaaaggaat ctaaaaaaat gctgattgtt aggtcgatgt aaagtgacgg 1165081 taaggatcgt agaaaatgtc ttcgtaatgt aatgacgctg aaattttctg aaatttatag 1165141 ggcaaatgaa ggaagttccc gcattttgta gaaatattga gggataggtt ttgaagaagg 1165201 agtgtacatg catggaaact cttggtgtcc agacaaactc ggagctgcga gaggaactga 1165261 atcgcctcaa agaagaaaac gcgcgactga aaaaggaatt gaatcagcat caagtgattg 1165321 tcaacaatac gctcgatgct atttttattt gtgataacga aatgcggatt gttcaggcaa 1165381 atgaagcaac agaaaggatg cttcaagttg actcggaaga tttgaaaaag cgttctgttt 1165441 tggatttttt gttttcaatc ccaaaggatg aactgaatct ttccgtaaag aagtttttta 1165501 aaaaaggctt tctgtggaag gaggttccga tcaggcttga ttgcggggca acaaaataca 1165561 tagagtttct ggccaaaaga ggtattggtg aggatttctt ttttgttgtc atgagggaca 1165621 tatcttctaa gaagattctg gagcgggaat tctctatgaa tgaacagctt tttaaggact 1165681 tgtttgacag agcagttgac ggaatcgtcc tgtttgataa agatggcggt tttattgatg 1165741 caaatttgtc cttttgtaaa agctttgaaa tcaatcataa tgagctgtct catttatctt 1165801 tgtatgagtt catagacagc ggctcacgaa aagatttcga caatatctgg aaggcgctca 1165861 accgcaaggg aaaagcgaag ggggagctgc ctgtcaagct tcgttcagga gttcaaaaac 1165921 tatttgaatt cacgattaca tcaaacatca tcagcggttt ttatatgtcc attatgaggg 1165981 atatcacaga gaagcggtct atggagctgc agctctttaa aagtgaggag cgcttcagag 1166041 aaatctttga aaatgcaatg gacgccatca tcatctggtc gaatgacgga agaatcgtaa 1166101 aagcgaatca atcagcctgt aaaatttttg agctgccgat gaatttgctg ttgaaaagaa 1166161 agctgtgtga ttttctcgtt gactcgcagc agaaatacag cataacgaag aggaaatacg 1166221 caaaatacgg agagatcaga gaagagctgc tgtttcaaat ggggaacggc caattcaaag 1166281 agcttgaatt tacttcaaaa cggacaatcc ttgaaaatca gcatttgacg atcttaagaa 1166341 atgtaagcga cagaaagcgg atggaaaagg agcttcggga aagcgagctg aaattcagaa 1166401 aagtgttcaa cggatcaatg gacggcaatg tattgttcga caatcaatac aggatcatcg 1166461 acgccaaccc gttagcaagc catattttgg gcctgtcaca tgaagagatc aaacagcaca 1166521 gcctgttaga tattatttct gcttatgaaa tagaaaattt ggcatcaccg gcaaggcaga 1166581 ttaattttga tgaaatggac aacgaaattc catttttgct gagcagcggt gataacagaa 1166641 aactcgaatt ctcatttaaa cggaatatta ttcaaaatat gaacttggct atctttaaag 1166701 acgtaacaga gcgaaaagaa ttggaggagc gcctgcgcaa atcagatacc cttcatgttg 1166761 tcggcgaact cgcagccggt attgctcatg aaatcagaaa tccgatgact gctcttaaag 1166821 gcttcattca gcttctgaaa gggagtgtcg agggagacta cgccctttac ttcaacgtga 1166881 tcacctcaga actaaagcgc atcgaatcca tcatcaccga attcttgatt ttagccaagc 1166941 cccaggccat tatgtatgag gaaaaacatg ttacccaaat tatgagggac acgatagacc 1167001 ttctaaatgc gcaagccaat ctcagcaatg tacaaatgca acttgattta attgacgaca 1167061 ttcccccgat ttactgtgaa ccgaatcagc tgaaacaggt ttttatcaat atattaaaaa 1167121 acgccatcga agtgatgcct gacggcggaa atatttttgt aacgataaag gcattggatc 1167181 aagatcatgt tctaatctcc ttaaaagacg agggaatcgg aatgacagaa gataaattaa 1167241 agcgacttgg tgaaccgttt tatacgacaa aggaacgggg aactggactt gggcttatgg 1167301 taagctataa aattattgaa gaacatcaag gcgagattat ggtagaaagt gaagaaggga 1167361 agggcaccgt tttccatatt acgcttcctg tcagacagaa tgctgaagaa agaaggaatg 1167421 atgaatgaac tactatacga cagccgaaac gccgctcggt gaacttatca ttgccgaaga 1167481 ggaggaccgg atcactcgtc tatttctcag tcaggaagat tgggtggatt ggaaagaaac 1167541 ggttcagaat actgagcata aggaaacacc taatcttgca gaagcgaaac aacagcttca 1167601 agaatatttc gcaggcgaaa ggaagacatt ctccctgccg ctcagccaaa agggcactcc 1167661 ttttcagcaa aaagtgtggc aagcgctgga gaggattcca tatggcgaat cccgaagcta 1167721 tgcggatatt gccgctgctg tcggcagtcc gaaagcggtg cgcgctgtcg ggcaggctaa 1167781 taaacgtaac gacctgccga tttttgtccc gtgccacaga gtgatcggca aaaacagtgc 1167841 gttaacagga tacgccggaa gcaaaacgga gatcaaagca tttttgctaa acatcgagcg 1167901 aatctcctat aaagaaaaat aaaacatatg gcacgttccc ttttttcacg gccgacatat 1167961 cattttatta agttaaaaaa gttggtctga tgaaaaagga ggacaaagca attgaagccg 1168021 agccgctctg agaaacttgc cgtttttgcc gaactgtttg tgaaactgca tatcttatca 1168081 agcgctcaaa aagatgaaat catcaatgtt aacaaaaaga aacaaaaaaa ccgctgactc 1168141 ggctccaaat gagcaaagtc cagcggtttt ttaatgcacc ttttctcctt taaacagctg 1168201 ttcaatctct tcttcatagt ttccggtcat aatccctttt tctgtgatga ttcctgaaat 1168261 gagatcatga ggtgtaatgt cgaaagcggg attaaagaca ggcacattgg atggagcggt 1168321 ccgaactccg gaaatctgcc tgacttcctc gggatctcgt tcctctatcg ggatatcagc 1168381 gccgcatttg acctttgtat caaatgtaga taaaggtgcg gcgacaaaaa acggaatatc 1168441 aaaggcgttt gctaaaatag caagaccgta tgtgccgatt ttatttgccg tatcaccgtt 1168501 ctttgcaatt cggtcggctc cgacgataac agcggaaatt tgtttttcct tcatcgtatg 1168561 ggcggccatg ctgtctgtga tcagagtgac atcaatgccc ccctgcatca gctcccaagc 1168621 agtaaggcgt gaaccttgca ggacaggcct tgtttcacag gcataaatgt gtaatcccaa 1168681 atctttttgt ttggccaagt aaaacggagc tagcgccgtt ccatagcggc ttgtcgcgat 1168741 tgagccggca ttgcagatcg tcatgatcct gtcgcctttt ttgaaaagct gcagggcgtt 1168801 ttggccgatc aaccggcacg tttcctcatc ctcgacctga atctgaatgg cttcatggac 1168861 aaggtttgtt tttgcttcat ttacggaaat cgcgttttcg accgaatgac tcagtctctc 1168921 aagcgcccat gacaaattaa tggcggtagg ccgtgagctg tttaaatatt gtttgatgtc 1168981 ttccagtctg cggcggaatt ccgtgacatt gtctgtttca atgtctttgg cagcaagcgc 1169041 cagtccgaag gcagctgtaa tgccgatcgc cggagcgccc cttactttga gcgtgacaat 1169101 cgcatcaaat acatcctctt tcgtcgtcag ctccaaatat tccgtctcat caggaagctt 1169161 ttgctgattt aaaatggtaa tagctgtttc tttccattca acagaacgtg gaacagcaaa 1169221 tgaatgggtc atgaatagat cattccttta caagtaactt aaataattca ataacatctg 1169281 ttatcgtttt gaattccgaa cgtttttcga taaaggctgt gccggtttcg agcgccaagc 1169341 gttttctgcc gattcgttta tcaaacggca cgatcgtatc caggtcagct acatgggcaa 1169401 ggccgatcgt gcgtcgtatc agctcacagc ccgcaaatcc gattgcttct tcaaaaatat 1169461 ggctgagcgt atcagtgagg taaccgtcga tgttggcgta aacatccaga ctgtccttct 1169521 gccaggcttc actaaacgtc tcttcaaacg tttcccagac ctggttgaca tgttcatata 1169581 acggctctct gtcagccccg tcacggctga gtgcgttcaa aaataagttg gcgataaatt 1169641 gccctacatc aaagccgatc ggtccgtaaa aagcaaactc aggatcaatc acctttgttt 1169701 cgtgctcact tgcgaaaatg cttcctgtat gcaaatcacc atgaatcaac gtttctgcag 1169761 acgttaaaaa tgactttttc agcttagcgg cttcgatttt aacgctgtca ttattccaaa 1169821 gcttttcgac aaaaggacga agctcttctt caaaatcatt tgtgtcatgg tcgaagaaag 1169881 gatctgtaaa aacaagtctt tccgtaatgt cgcatagctc tggatttgta aactgtttaa 1169941 caagctgttt tttcacctta ggttcaagcg cgtaatctga tgagtagaaa agtgtttttc 1170001 ctaaaaattc accgatgtgc tgcgacagat gaggatagtt ttcaccctca atgagtcctt 1170061 ttcttgcgat cttgaggtga gagagatcct ccatgacggt aaccgccatt tccgtatcag 1170121 aataaaacac tcttggaacc aggtgaggca catgctcgcc ctgacggatg agagcgctgc 1170181 tttcgattct tgcacggtcg attgtcagcg gccagctttc tcccaccact tttgcatacg 1170241 gaaccgcctg tttaatgatc aatgctctgt catgttcttg atcataaata tgaaaaacgt 1170301 aatttaagtt gccgtctccg atctcctggc atgtcagcgt gcttttgctt ggaaataggc 1170361 caagcttcac cgccaacgcc acagcggagc tttcatttaa cgtttcgtat aaaggtgttt 1170421 ttgtgactcc catcatcata acctccaatt atgtaattaa ttaatatgtg gccgtaaaaa 1170481 agcctccttc tcagagagaa ggaggcttaa catctatgtc cgcctctctt atctctcaga 1170541 tcagatctga atggaattag caccgtgcct taagagacca gcgtctcggc gcgaaaaaaa 1170601 tgcgccccat ttcacaatgg aattacggtc ggttgctttt ggggtcaaaa ggccaaatcc 1170661 ctcgcccaac tctcgataag agaatatatt cacttgtttg acaattctaa tttatcagtt 1170721 gatgaacatg gtaacaggta atttagttag ttgtcaatat attttttaat ataaatcttt 1170781 tctgatatca tcgaaaacag gaatgctctc ccgaacttct gcgctttctt gaaggtcgat 1170841 ttccgctcgg actatgcctt cttcccggcc gccttcagca agtacacgtc cccatggatc 1170901 aataatcagg ctatgtcctg caaattcatt atccggattt gaaccggtac aattgcaggc 1170961 tgcgacaaag cattggtttt caatggcccg cgcaataagc aggcttttcc aatgatcaag 1171021 gcggggaaga ggccattccg cagaaataaa cagcacgttg gcgccttttg tcgtatgttt 1171081 tctgatccat tccggaaaac ggatatcgta acagatcaat ccagagcttt tgacgccgtc 1171141 aagctcaaag tatccgtctt cggaaccggc tgataaatac agatgctcat ccatcagctg 1171201 aaaaagatgg gcttttctgt actctttaat gatttgccct tccttatccg cgatgtacat 1171261 tgtattataa acatcagaat tcttcctgac agcgaccgat ccggcgacaa tatgaacacc 1171321 atgttttttt gccgttttct tcagccagct ctgagcggag cggccgtctt cgtcagcgag 1171381 ttcatcaaga ttggccagat catatccggt cgtccataat tcaggcagaa caagaacatc 1171441 agcatgtttg ctttcttttt cgatgaaaaa ttcagccttt tttatatttt ccgaaggttt 1171501 tccgtatgaa atatcaaatt gaagacaaga tatcgtccat ttcatctttt taacacccca 1171561 aatttttctt tacttttttc atttaaccat atatgatgat ggactatcat ttcaagattt 1171621 ttttagaagg tgagaataga tgaaatttga acagtctcat gtattgaagg aattgcctaa 1171681 acaattcttc gcttctctgg tgcagaaagt gaaccgaaag cttgcagaag gacatgacgt 1171741 tatcaatctg ggacagggaa atccagatca gccgactcct gagcatattg ttgaggagat 1171801 gaaacgagct gtcgctgatc ctgagaatca taaatattcg tcttttcgcg gctcataccg 1171861 tctgaagtca gcggctgctg cattttacaa aagagaatac ggcattgatc tggatccgga 1171921 aaccgaagtc gctgtattat tcggcggaaa agccggtcta gtcgagctcc cgcaatgctt 1171981 gttgaatccc ggtgatacga ttttagttcc cgatccgggt tatcctgatt actggtcggg 1172041 tgtcacactt gcaaaagcaa agatggaaat gatgccgctc gtaaaggaca gagcgtttct 1172101 ccctgattac agcagcataa ccgctgaaat aagggaacag gcgaaattga tgtatttgaa 1172161 ttatccgaat aatccgactg gagctgttgc tacttccgag ttctttgaag ataccgtgcg 1172221 ttttgcggct gaaaacggaa tctgcgtcgt tcacgatttt gcttacggcg ctgtaggatt 1172281 tgacggctgc aagcctttaa gctttttgca gactgaaggt gcgaaggata tcggaattga 1172341 aatttacacg ctgtcaaaaa cgtataatat ggcaggatgg cgggttggct ttgccgtcgg 1172401 aaacgcttcg gtcattgaag cgatcaatct ttatcaagac catatgtttg tcagtctttt 1172461 cagagcgact caggaggctg cagcagaggc actgttagcc gatcagacgt gtgtggcaga 1172521 gcaaaatgcc aggtatgaga gcaggagaaa cgcttggatc acggcatgcc gggaaatcgg 1172581 ctgggatgta acagctcccg caggttcttt ttttgcatgg ctgcctgtgc ctgaaggcta 1172641 tacttctgag cagttctcag atcttttgct ggaaaaagcg aatgtggcag ttgcggctgg 1172701 aaacggcttc ggtgaatatg gcgagggcta cgtcagagtc ggacttttaa caagtgaaga 1172761 aagacttaag gaagccgctt atcgaattgg caaactgaac ctgtttaccc aaaaaagcat 1172821 tgacaagacc ttataacgat gggataattc aaaataattt ataaaatcta tattttctta 1172881 tcaagagcag gcagagggac gagcccgatg aagcccggca accgacttat aaagcacggt 1172941 gctaattctt gcagctagcg gctgagagat aagattcgga cgagaaacga aacctcttta 1173001 gacgcgattg cagtttgaag aggttttttg atatggatga aaatgaaagg agctctggca 1173061 tgagtgagtt attagcgaca tatctcctga ccgaaccggg agccgataca gagaagaaag 1173121 cagaacaaat cgcaacagga ttgacagtag gctcctggac tgatctgccc cttgtaaaac 1173181 aggagcaaat gcaaaagcac aaggggcggg tgataaaagt tgaggagaga gagggaactg 1173241 ctgcatcaga aaaacaagcg gtcatcacaa ttgcctatcc tgaaatcaat ttctctcagg 1173301 atattccggc tttgctgaca acagtgtttg gcaagctgtc cctggacgga aaaatcaaat 1173361 taatcgatct tcacttctct gaagcattta agcgtgcact gccgggaccg aagtttggcg 1173421 tatacggcat ccggaagctg ctgggagagt ttgagagacc gctgttaatg agcatattta 1173481 aaggcgtaat cggaagggac ctgagtgata ttaaagaaca gctccggcag caggcgcttg 1173541 gcggagttga cttgattaaa gacgatgaaa ttttctttga gactggtcta gcgccttttg 1173601 aaacaagaat tgcagaagga aagcaaatat tgaaagaaac gtatgaacaa accggacata 1173661 aaacgctgta tgcggtgaat ttgaccggac gtacggctga tctgaaagac aaagcgagac 1173721 gcgccgccga attgggagcg gatgcgcttt tgtttaatgt cttcgcttac ggcttggacg 1173781 ttatgcaagg ccttgcagaa gatcctgaaa tcccagttcc gattatggcg catccagcag 1173841 tgagcggagc gtttacgtct tctccgtttt acggtttttc tcacgctctt ttactcggaa 1173901 aattaaaccg atattgcggt gctgacttca gcctctttcc gtctccatat ggttcggttg 1173961 cgcttccaag agcagatgca ctggcgattc atgaagaatg tgtgagagag gatgctttta 1174021 accaaacatt tgctgttccg tcagcaggca ttcatcccgg catggttccg ctattaatgc 1174081 gtgatttcgg catagaccac attattaacg ccggaggagg cgtacatgga catccgaacg 1174141 gtgcccaagg cggggggcga gcgttcagag ctattattga tgcggtccta gaggcccagc 1174201 cgattgatga aaaagccgaa caatgcaagg atcttaagct tgcgctagat aaatggggaa 1174261 aggctgaagc cgtatgacga ctcgaaaacc ttttattatt tgtgattttg acggaacaat 1174321 cacgatgaac gacaacatta taaatatcat gaaaacattt gctcccccag agtggatggc 1174381 attaaaagac ggcgtacttt ccaaaacgct gtcaatcaag gaaggtgtcg ggcggatgtt 1174441 cggccttctg cccagcagtt taaaagaaga gattacaagt tttgtattgg aagatgcaaa 1174501 aatcagggaa ggctttcggg aatttgtagc atttatcaat gagcacgaga ttccgtttta 1174561 tgtcataagc ggtggaatgg acttttttgt atatcctttg cttgaaggca ttgtggagaa 1174621 agaccgcatt tattgcaacc atgcttcatt tgacaatgac tatatccata ttgactggcc 1174681 tcattcctgc aagggcacat gcagcaatca atgcgggtgc tgtaagccgt cggtcatcca 1174741 tgaactttct gaaccgaacc aatatatcat catgatcggt gattcggtta cagatgtgga 1174801 ggcagcaaag ctgtctgacc tatgctttgc aagggattat ttattaaacg aatgccggga 1174861 gcaaaacctc aatcatcttc cgtatcaaga tttttatgag atcagaaagg aaattgagaa 1174921 tgtaaaggag gtacaggaat ggctgcaaaa caagaacgct ggcgagagct cgctgaagta 1174981 aaacgggaat tggcagagag agattggttt ccggcgacta gcggcaatct gtcaattaag 1175041 gttacagatg agcctttaac atttctcgtc actgcaagcg gaaaagataa acgcaaagag 1175101 acggttgaag attttctgct ggtcgatcaa aacggagagc ctgctgaaag cgggcattct 1175161 ctgaaaccgt cagcagaaac gcttttgcat acacatttgt acaataaaac caatgccgga 1175221 tgctgcctgc atgtccatac ggtaaacaat aatgtgattt cagagttata cggagaccaa 1175281 aagaaaatca cattcaaagg ccaggaaatt ataaaagcac tcggcttgtg ggaagagaac 1175341 gcagaagtga ccgttccgat tatagaaaat ccggcacata tcccgacgct agcggcactg 1175401 tttgcggaag agatttcaga agattcagga gctgttctga tccgaaatca tggtattacg 1175461 gcttggggga aaacagcatt tgaggcaaaa agagtgcttg aagcgtatga atttttgttc 1175521 agctaccatt tgaaattgaa aacactcgag catcagctgg ttaaataaaa ggaggaattg 1175581 aaatggctac aattcgaatt catgatgagg caaatacaac gattgaaaat caagaggaag 1175641 tggcaagctt tctggacagt caagaggtta tttatgagca atgggatatc acgaggcttc 1175701 cggaacatct ctcagagaaa tatgacctga cagaagaaga aaaacagcaa attcttgata 1175761 ccttcgaaac tgaaattaaa gatatctcaa cccgccgcgg ctataaagca caggatgtta 1175821 tttcattgtc agacagcaat ccgaaacttg atgaactgct tgaaaacttt aaaagagagc 1175881 atcaccatac agacgatgag gttcgtttta ttgtaagcgg acacggtatt tttgtcattc 1175941 aaggccagga cggcacgttt tttgatgtcc gtttaaaccc tggagattta atctccgtgc 1176001 ctgagaatat ccgccattac ttcacgcttc aggaggaccg caaagttgtc gcggtgagaa 1176061 tttttgtcac aactgaaggc tgggttccta tttatgaaaa agacagcgtg aatcaataag 1176121 cgtgagatag ccccgttcat cgaacggggc tttttatatt tattgcaaac gccacttttc 1176181 atattgtgac agttcttttt taatcagtgt ccaaatcaaa cctaaaacag ctgcatcgtc 1176241 aatgaatcca agaccgagga ttacgtctgg aatgatatcg agcggcatga cgatatacag 1176301 gattgcggca gttaacagca aaagtgtttt aacctgtgaa cgagggtagt cgccatttcg 1176361 ccaatcgcga agcatctgaa aaaaagtagt gatgtgctgg atacattttt ttcggttttt 1176421 cctctttaaa atcgcttttc cgcctgccgc tccgagcatt attgctttct ttttcttcat 1176481 tgggcatacc tcctgcctgg cggcgtgttt aagatattct tcacctgggt attgttcttc 1176541 taatcctatc aatatatcta ttatacctga aaaattaact tatttaatga aaatatgttt 1176601 acaaataaag tataatctgt aataatgcac aataacccaa tcaaacttgt ttcctatttc 1176661 ttagcggcga ggggtgaagt gaatgggcgg ttcttctgaa caagaaagat tgttggtgtc 1176721 tattgatgaa aaaagaaagt taatgataga tgccgctaga aagcagggat ttacagggca 1176781 tgacacgatc aggcacagtc aggagctgga ttgtttaata aatgaatatc atcagcttat 1176841 gcaagaaaac gaacattccc aagggattca aggccttgta aagaaattag gcttgtggcc 1176901 ccgcagagat gttatgccag catatgatgc aaataaatag cggcctatca gatgcatata 1176961 taaagagaga gcttttcgga agcgctcttt ttttctggaa aaaattcata tgaaagaggg 1177021 aactaatgaa ggaactggcg attctcatta ccgaaatggt caatcaattt catgatgctt 1177081 ttatttcctt atgcggaata tttggcattc atttaactga caaagaaatg catttttggg 1177141 tgatcggcat ttttggcata ttctttttcg gcgtcactca cgctgtgttt acatggcttt 1177201 ctaaatggag tatgacagcc ttgtccttta tctataccgt tacagtcatc attgtcatcg 1177261 tatttgcgat tgagattcag caaaaggtga cggggagagg gaatatggag tttttagatg 1177321 ccacggaagg tataaagggt tttttagtat tttttatgtt ttttttgctt ttgaaaatgc 1177381 tgttgcgttt catcaaaatc cttttttctg gaagaccagc aagcaaatcg aatggcaatg 1177441 cccgatcacg aagataaaaa accctcctga catggtcagg ggggctatga tgcggatacg 1177501 gggagggtga tcgtcacctc tgtgcctctt cgcccgctga ttgttatttt gcttctgtgc 1177561 ctcttcgccc gctgattgtt attttgctcc tctgtgcctc ttcgcccgct gattgttatt 1177621 ttgccctctg tgcctcttcg cccgctgatt gttattttgc tcgcactttg attttatcat 1177681 cttctaaaat cacgtgaaaa cttgtgatct cgccattatc aagcagcaga tcggtcattt 1177741 catcctcaac ccattcttgg atggttcttc taagcggacg tgcaccgaat gaagggtggt 1177801 agcccagctc agcgattttt tctttcgctt catctgtcac attcaagcta atgccccgtt 1177861 ccgccaatgt ttcttcaagt tctccaagaa gaaggctgac gattttgaca agatgttctt 1177921 tttccaatga gcggaactca ataatgctgt caaaacggtt gaggaactca ggtttaaaga 1177981 acatgctcag tgaatcaatt aatgtttgtt cttcgatgac actgtcatct gattggaaac 1178041 cgactttcgt ttgtttctca ccagcacccg cattacttgt catgatgatc acagtgtctt 1178101 tgaagcttac agttctgcct tggctgtctg tcagacggcc atcttccata atttgcagga 1178161 acatatgctg aacgtctggg tgtgcttttt caatctcatc cagcaacaca atgctgtaag 1178221 gattgcggcg caccttctca gttaattgtc cagcttcctc atggccgaca tatccaggcg 1178281 gtgaaccgat aattttagat acggcgtgtt tctccatgta ttcgctcata tcgagtcgga 1178341 taatagcgtc ttttgtgccg aataattcat ctgccagtgt tttagaaagc tctgttttcc 1178401 ctacgccggt aggaccgacg aagaggaagg agccgactgg tctgtttttg gattttaatc 1178461 cggcgcggct tcgtcttacc gcttttgcca ctttttgaac agcggcttct tgtccgatca 1178521 cgcgttcatg aagttttgct tcgagttctt tcattttcgt ttgttcgtct gcctgcagtt 1178581 tgccgacagg gatgcctgtt ttttgttcaa caatttcctg aatgtgctca gcttccacag 1178641 tgacagcggt atgagcggag gagctgttca gttttttctc caatgcgagt tcttcatcac 1178701 ggagttttgc cgccagttcg taattttctt cttccagggc ttttgttttt tcggcttcaa 1178761 ttgcagttaa gcgttcagcg gcatcctcat cattcagttc atcaattaac aggttggctt 1178821 ttgaacctgc ttcatctaat aaatcaattg ctttatccgg caggtgtctg tcctgaatgt 1178881 agcgggatga taaagtgaca catgctttga ttgcttcatc actgaatgtt acgccatggt 1178941 acgcctcgta tttgtcttta atcccttgca gaatgaggat agcctgttca attgaaggct 1179001 cctgcaccat gacaggctga aaacgtcttt ccagcgcggc atctttttcg atttgacgat 1179061 attctttcag tgttgtcgcg ccaatgactt gcagttcgcc tctggctagg gccggtttga 1179121 gaatgttgcc ggcgtccatt gatccttctg cagagcctgc gccgacgaga aggtgaattt 1179181 catcaatgaa cagaatgaca ttttttcgtt ccttcagctc agtgatcagc tgtttcattc 1179241 tctcctcaaa ttggcctctg atccctgtgt ttgcaacaag agatgcaaca tcaagcaagt 1179301 atagctcttt gttttttagt ttgtttggaa catcaccttc agcaattttt aaagcgagcc 1179361 cttcagcgat ggcagttttc cctacacccg gctcaccaat aagaaccgga ttgtttttgt 1179421 ttcggcggtt tagaatttcg atcactcgcg ccacttcatc atcacggccg atgacgggat 1179481 caatgagacc ggcttttgca ccgtttgtaa tattttgagc cagctcatca agcaaccctt 1179541 ttttttcgct ttgttttgct gcgctctgtt ctttcggctg gaatgcctgt tcaaacggaa 1179601 atccgaaaga ttgaggaccc atactcattg aaggtttacg ggtcagttcg ttatagcaag 1179661 tttcacaaag aaccatctgt ttatgaacgg aatttatttg catgttaagg cgaatcgtcg 1179721 cctcgttttg atgacaatgt tgacaacgca tttgccaaaa cctccttaat aatttgatca 1179781 tctttgacca atgaaagtga ataaaaaggt ctattgggtt tgaccttctt tgactattag 1179841 tatacggcaa acttaacggc attcaaacca atatgctcaa agcagactga atatttgact 1179901 atctttgacc aattgatttt taaaaaaggc cggtttgttt gaccaacttt gattaatagt 1179961 atactctgac tatctttgac tttcaagtct tatgcacaaa aatttttgat ttgttacaaa 1180021 gtaaaacatg ttttcttcgt cttttcaagg aacttgtctc ataggttata aaaaggcata 1180081 tatggacaaa actgcggttc gttcggaggg aagaaatgga acaatcaaaa gggtctgcaa 1180141 gtcagcttgc ttttgtgtat gtcggcacag tagtcggagc tggatttgcg actgggaggg 1180201 aaattgttga gttttttctg aagttcggct ggttcggttt tttcggcatt ctcgtcagcg 1180261 gcggaatgtt tacgttactg ggggccaagc tgatgatcat ttcaaagcga atcaatgcca 1180321 agtcatatca agaaatgaac atatttttgt tcggggcgac ggctgggcgg attatcaatg 1180381 tatttatgct gtttgttctc cttggagtta catctgttat gctttcaggg gcaggggcgc 1180441 tttttgagga acagctgggg atgtccgctc agattgggat gctcattaca atcggtctga 1180501 gtttaattgt gatgactaga ggagtaaaag gcattttcgg tgtcaatgtg tttgttgttc 1180561 ctcttttaat catcttttca atgattgtgg tggccgactc ttttatattc agcgaatcac 1180621 gaaacgcagc tcagtgggtc tggccgcatc gctgggattg gctgttatca gcagtttctt 1180681 acggggcttt aaatttatcg cttgcccaag ctgttttggt tccgctggcg aatgaaatgt 1180741 catcggagaa agtgataaaa aaaggcgctt taatcggagg cacgatgctg acgattgtgc 1180801 tgtccgcgag ttttctgtct ttgtcgactc ttccggatgt atttttgtat gatataccga 1180861 tggcgcaagt ggtttatctc tttgcacgat ctgtccattt gatttattta ctcattattt 1180921 tcggagaagt gttcacatca gttatcggta atctatatgg attagaaaaa caagtgcaaa 1180981 gctttcttcc agtgaaaagc aaatatatct ttgcagccat tatgatcacg gcttatatta 1181041 cgagccaaat agggtacggc aggcttattt caacgattta tcccttgttt ggctatgtga 1181101 gcctggcctt cataggcgct ttgctttgca aaaaagctcc tcggcggcgc agtttataaa 1181161 tatatataat gaaacgaacc gtcactatag agcgataatt gatctaggaa ccggggactg 1181221 acttttttat tgtcaagaaa aacatcatta tggtaagata gcagaagtga aaaaattgaa 1181281 gaaaatccgt gcgatatgcg ggagaggttc tagctacacc ctctataaaa aactaaggac 1181341 gagctgtatc cttggatacg gcctttttta tgtttttcta gagcaccttc cgaaaaaagg 1181401 tgtttttttg cgtgaattag ctgtagcgat gtctctcgcc ggcgttttta ttgcggagaa 1181461 ggagaggaat catgaaaaaa gaaaaagcaa ttgtcgtatt tagcggcggt caagacagca 1181521 caacatgctt actgtgggcc ttaaaagaat tcgaagaagt cgaaacggtg acttttcatt 1181581 ataatcagcg acattcgcag gaagttgaag tggcaaaatc cattgcggaa aagcttggtg 1181641 tgaaaaatca tttgcttgat atgtcacttt taaatcagct tgcaccgaat gccctgacta 1181701 gaaatgatat tgagatagaa gtaaaagacg gcgaactgcc atccacattc gttccaggcc 1181761 gcaatttggt attcttatcc tttgcgtcta tcctggctta ccaaattggc gcgcgccaca 1181821 ttattacagg agtttgcgag acagacttca gtggttatcc tgactgccgt gacgaattcg 1181881 tgaaatcttg caatgtcacg gtaaatctgg caatggagaa gccgtttgtg atccacacgc 1181941 ctctcatgtg gctcaataag gcggaaacgt ggaagcttgc agatgagctt ggcgcgctgg 1182001 attttgtgaa aaacaacacg ctgacatgct ataacggcat catcgcagac ggctgcggcg 1182061 aatgtccggc atgtcacctt cgttcaaaag gttatgaaga atatatggtg atgaaaggag 1182121 agcgtgcata aattgttatc tcaaatttat ccgcaggccc agcatcctta ttcgtttgaa 1182181 ctgaataagg acatgcatat ctcagccgct cattttatcc ctcgggaaag tgcgggagcg 1182241 tgcagcaggg ttcacgggca tacgtatacc gtaaatataa ccgttgccgg cgacgaactt 1182301 gacgattcag gctttcttgt caatttcagc gtactcaaaa aactggtgca cggaaactat 1182361 gatcacacgc tattaaatga tcatgaagat ttttctcagg acgaccggta ttcgctgccg 1182421 acaactgaag tcgtggcgaa aacgatttat gacaacgtac aggcttattt agacactttg 1182481 gagaataagc cgacctgtgt acaggtgttt gtccgtgaaa caccgacaag ctactgtgtc 1182541 taccgtccga aaaagggtgg tttgaatggc taaaggaatt cctgtattag aaattttcgg 1182601 cccgacgatt caaggagaag gcatggtgat cggacagaaa acgatgttcg tccggacagc 1182661 cggctgcgat tattcctgca gctggtgtga ctccgctttc acttgggacg ggtctgctaa 1182721 aaaagatatt cgctggatga cggcggagga gatttttgcg gagcttaagg acattggggg 1182781 agatgcgttt tctcatgtga cgatctcagg cggcaacccg gctctgttaa aacagctgga 1182841 tgcttttatt gaactgctga aggaaaataa catccgtgca gcgcttgaaa ctcaagggac 1182901 cgtttatcag gattggttta cgctgattga tgacctgaca atttctccaa aaccgccaag 1182961 ctcaaaaatg gtaacgaact ttcaaaagct tgaccacatt ttaacttcac ttcaagagaa 1183021 tgatagacag catgctgtca gcttgaaggt tgtcatcttt aatgatgaag atctggaatt 1183081 tgccaaaact gtgcacaagc ggtatccggg aatcccgttt tatttacaag tcggaaatga 1183141 tgacgtgcat acgacagatg atcagtcact gattgcacat ttgcttggaa aatatgaagc 1183201 gcttgttgat aaggtagctg tcgatgcgga gctgaatctc gtcagagtgc tcccgcagct 1183261 gcacaccctg ttatggggca acaaacgcgg agtataatag aaaggaagat gaacatgacg 1183321 acaagaaaag aatcagaatt agaaggtgta acattgctag gcaatcaagg tacaaattat 1183381 ttgttcgaat atgcaccgga cgtgctggaa tccttcccta ataaacatgt aaaccgtgat 1183441 tactttgtaa aattcaattg cccggaattc acatctttat gtcctaaaac aggccagcct 1183501 gactttgcga caatctacat cagctacatt cctgatgaaa aaatggttga aagcaaatca 1183561 ttaaagctgt atctattcag cttcagaaac catggtgact tccacgagga ctgcatgaat 1183621 atcatcatga acgacttgat tgaattaatg gacccgcgct acattgaagt atggggcaaa 1183681 ttcacgccaa gaggcggaat ttccattgat ccgtacacaa actacggaaa gcctggcacg 1183741 aagtatgaga aaatggccga ataccgtatg atgaaccatg atttgtatcc ggagacaatt 1183801 gataatcgtt aattattccg ttgtgtgata cggagtgtaa aaggaagtgg agtcacagta 1183861 aaatccgaac attcagcgtt aattttcagc ggaaatgtga cctggtcaca gcgaagtgtg 1183921 acccgcacta agctcaataa aagtgggaaa agtcacacct gaaaatggct ctactcatgg 1183981 gaattgtatt aaaaagtgtg acctgaggtg caacctgaac tgtgactttt atgcagtgaa 1184041 aaattgatag tacagaagca gattaaggcg tacaatttgt acgtcttttc ttttttatcc 1184101 gaaagaaaaa atgcctatct agagatcata ggcattaaat attattatca atatcttcat 1184161 ttattttttg gctaagtttc tgaaccttct ctttaacatt tgaaacagct cttttttgaa 1184221 tttcatcaat tctcctgaat atagtcgatg acacttctta ttagaacttc actttcaaaa 1184281 ttgaatatct catttatttc tgactgttct tcatctgtta ggtgatggta ttgaagttgt 1184341 ttagcattta cttcagcagc tacatcaatc ctaacttagt tgttctggtt gtacaatttc 1184401 atattcacct tctgcatact cttgctccgc ataatagcct ccccattgac agagctcctg 1184461 caagataggt ttaagagatt ctccaagttc agtggatgaa tattcaacct tcggcggtac 1184521 ttgattatac atctttctgc tcacaagtcc actggcttca agctctctaa gtgtttgaat 1184581 cagcattttc tgagttatat ttgggataat gcgctttaat tcactcgttc tctttggtcc 1184641 attcattaaa aagtataata caaggccttt ccattttccg ccaataactt cctttgtcac 1184701 ttcaaaccca cagctaaatt ttttcatgtc taaagctctc cattccacat ttattacttt 1184761 ttagttacta tatcacaaaa aagtgggtac ttccgataat gtgcttactg aaggatacta 1184821 tatcttgtaa gttgttcttc aagtacttaa aggtactaga cataaaataa aattaattct 1184881 aaaggagtgt taagtatggg taaatttgaa ggtaaaatag cgcttgtaac gggtggaaca 1184941 agtgggattg gtcttgctac agcacaaaaa tttgtaaacg aaggtgcata tgtttatatt 1185001 acgggacgta gacaaaacga acttgataaa gctgttaacc aaattggcaa gaacgtaacc 1185061 ggtgttcaag gtgatatttc taagcttgaa gacttagaca aactatatga cattataaag 1185121 caggaaaaag gtaagttgga cattcttttt gctaatgcag gcatcggcaa cttccttcca 1185181 ttaggtgaaa ttactgaaga gcaggttgat agaacgttcg acattaacgt taaaggaacc 1185241 atctttactg ttcaaaaagc gttatcacta ttcccggaca aagtaggttc tattattgta 1185301 acgggctcta ctgctggatc aattggcaac ccagcgttta gtgtatatgg agcatctaaa 1185361 gcagcattaa gagcactagt tcgcaactgg attcttgacc taaaaggtac tgaaatccgt 1185421 gtaaatgtgg ttagtccagg aggtattctt acacctgcct acgatgagct ttttggtgat 1185481 gcacttgaag aggtactgga aaatagcaga aatactgttc cagctggaaa agttgggaca 1185541 cctgaagaag tagcaaacgc tgtatctttc cttgcttcag acgaaagcag ttacttgacg 1185601 ggtgttgaat tgttcgtaga tggcgggcta gcacaggtat aatttcactg cgcagagatt 1185661 acaaatagtc cccaaaaaag gttaatgggg atttacttga agaagtcgta taaaaaagtc 1185721 gttttcctta aaggacaggg aattcgactt ttttatattt gaatttgatt aacgttgtaa 1185781 attcgcattt tcctggggct actactaaat gacctgtaaa aaagattaca ctgtgaataa 1185841 atgtacttaa agtaacgggg gctcttgact tttaataaaa aataatatcc ctgtccttgt 1185901 attctaatac ttttaaaaat atttaaagga atccttatgt cctgaataac cacataggaa 1185961 aatatgttgt aggttgcttt ctttttttgt ggggcatccc acacaagcta tctcgtgatc 1186021 tcacacctga acgtttttta tagactagta ccgcgacaag ttatattaca tatacatacc 1186081 aataaagtag acattaaaaa gtgaaagaga ggatggaaat gtgtgaaaat tcttttcctt 1186141 gagagtcatc ccatgtggct ctatggttta ccgaatgggt ttagggaagc aggacatacc 1186201 gtaatgattt ccggtcctgt aagtcgggaa aatataactg aaatgataga cgaatttaaa 1186261 ccagatttaa tagtatctat gggatggaca ccagagcatt caagggaaaa gcaggcctgg 1186321 attcgcaacg ctactaaaaa ggtgaatatc cctctcgttt attgggcaac tgaagacccg 1186381 ctgcacactc aaaactttac tatcccgtta attaaaaaga tgaaaccgga ttttgttttc 1186441 acggtcacgc cttctctgtg taaaacttat gaaagcatgg ggattaaagc agctcactta 1186501 gactttgcat ttcacgaaag tatacatcac cagattaaac cattagcgaa atacagttgt 1186561 gatatagcag tggtggctaa tgcttaccct aattttcttg aagaacatcc ggaagtgttc 1186621 cgttcgtcct ctttaaaaac gcttattcgt cctcttatac ggaagggtat tcgcattgat 1186681 ttttggggga gaaactggga aaaaatgagt aaatatatag gaagagaaat tccccgcaat 1186741 tggatccatg gataccttga ttatactgaa gcatataaag tttacagttc agcaaaaatc 1186801 attatcggtt tgcaaaactg tgaaagccaa cttacacaac gcacctatga gattcttggt 1186861 tccggggggt ttttattgac atcggataca ccagcagttc gaggtaaatt caaacctggc 1186921 cgcgatctca tcgtttcttc ctccccaaaa gaaacattgg aaaaggttaa atactattta 1186981 aatcatgata gcgagagaaa aaagattcag ataaacggta aaaaggctgt aaagaatgat 1187041 tcctatcggc atagagccga gagaatgctt gaggtgctaa aaagcagagg aatcataaga 1187101 aacttagggg aaaccattca ttatgtagat gttctcaaag aaaaatacgt gatccatcat 1187161 gttactcccg gtgaaacatt atcaataatt gccagtaagt ataatgtttc cctgcagcaa 1187221 ctcatggagc ttaatcattt caaatcagat caaatatatg ctggacaaat cattaagatt 1187281 agagagaaac tgtttagaaa tattaataac aaattattct aaaggagagt aatatgaatg 1187341 aaggggaaaa tacctaaaat aagaaatcaa gcgaataaag taaaaagaac gcctcgttat 1187401 atggaatttc ccgtgacata cgaagtatat catgtggaat ccggcgatac attatggacg 1187461 attgccaaat cctttgaaat tccggtacaa caacttatga atcttaataa gctttcttca 1187521 gatagaattt atcctggaca aattataaag ataagagaaa gataatcttt gaggtttcgg 1187581 aagcgaatca aattgaaatg acaatcctca tttttttatt tgtggggaac ttgatatttt 1187641 tggggatgaa ggggttatga gatgtttcaa atgagctatt actattctgg attaggatgg 1187701 gactttattc aacacgttga tcaaacgaac ggagtattaa atgttgtgtc tcctgatttt 1187761 ttctatatca gaaaagatgg atcattactt ctccgttcag ctaatcccga tgtgattaaa 1187821 gctcttcata gaagaaaatt aaaagtagtt ccttttctaa gcaatcattg ggatcaggat 1187881 ttgggacgat ttgcattaat gaaccgagtt cttttagcta aacaaatttc tcatgcaata 1187941 gaagaactgg atttggatgg agttaatatc gatatagaaa accttacaga aaaagatcgg 1188001 aatctattta cagattttat tagattagta aggaaaagta ttcctagaca taaagaagta 1188061 tcagttgcag tggcggcaaa tccttttggc tggacgaagg gctggcacgg atcatatgat 1188121 tacgagtatt tagctaaata tgcagattat cttatggtta tggcctatga tgaaagccgc 1188181 cttgctgggc ctactgcaag tgtaggatgg gtggaaaagt ccattcaata tgttctgacc 1188241 caaaaaatct ctcctcaaaa actagtttta ggattgccat tctatggccg ctgctggatg 1188301 gaaggccaat ctgcctctca agccattccc ctttaccttg ttgttagtaa aaaggcatag 1188361 cgggacaatt atttttgaca ccaagagtca atctccaaaa gctattttta ctgtcaatca 1188421 cgataaaaag gggccgttgc cttcgggaac atatacatta tggtttgaaa atgaacagtc 1188481 actcagagca aaaataaaac tcgctcaaaa atataatctg aaaggtcttg gcagctggag 1188541 tcttggacaa gaagatgcgt cagtctggaa tacagtgttt aaaaatatat aatgatttat 1188601 agttcagaac aaaattcgaa gataattgca atgaatctct aaatggacat actgaaagga 1188661 gtttattacg agtgcgggta aaacagtgag ggcattccat aggcccttct cccaaaatgt 1188721 tctacacgag gcattacatt gggcttgaaa tacacattca aacttatgtt atagtacgca 1188781 ttttacggat gtgttgaatt tattctgctt ccatgattta atcatacaca tgctacttga 1188841 tagcagggtt atcgcatttc attcagaatt gttcaggatc gatatggaag cgcacgacta 1188901 actagaactt taaaagcata cactcatata cttcctgaat ggatgctggt ttatctaaaa 1188961 aacatgatga gaattgattg tacgcatggt gaagcatgac ttgttgataa tcgaccatat 1189021 ggtttctcct tagaaatgag ggggttttta cataaaaaag acgagcgaat ccggggggaa 1189081 ttccactcgc cgctttctaa tgaaaagacg ggatgctgga tggcagctcg tctgttttat 1189141 tataatttaa cgaacgtatg tttgtaaagg tgtcttttcg aatgaattgg ttcatataac 1189201 cgttaagaac agattcattg taaacattcg ctaaggtatg ctaagatgca tggactataa 1189261 aggagtgata tgaagtgaag acattgcggt taaacaatgt aacgttagaa atggctgcat 1189321 atcaagagga gagcgagccg aagcgaaaaa ttgcatttac cttaaacgtt acgagtgaga 1189381 cttaccatga tatcgctgtc ctgttgtatg aaaaaacgtt taatgtcgag gttccggaac 1189441 gcgatcttgc cttccggggg gaaatgacaa attattcaac atcattgacc aacctgtacg 1189501 aaccaggggc cgtcagcgag ttctatatag aaataacgga aatagacaaa aacgccgatt 1189561 catgatcggt gttttttatg taaaaaagct gccggccggc agcttttgag aaagcgaatt 1189621 tcatatgtaa ggtgttaaat tgtccgtctt gcagtttttt gaataaatgt ggaaataagg 1189681 aggttttaat aggagtctct gatgatctta taatttttat gattaacaac tgtcaatgaa 1189741 tctaactcaa gatcccgata gttatccatg atcgtcacat caacgataac agaattctca 1189801 tttacttttt caacaacacc ggttaatccg tttttaaatt caatgacatt cccaacctta 1189861 gcgattttca caagcttcct ctcctttaaa cataataatg ccttttgaaa gtattttgca 1189921 gtattttcat tgagaagtaa agcgataagg agttttatct cccttatgaa ttgttctgtc 1189981 gctataaaga tgatatattg attttcgtca atagaaagaa aaggggggaa tttttgttgc 1190041 gtcccgaaga aataacagaa atgattgaac agctgcgcac cggcgccata aacgaactga 1190101 gagtccagaa agagcatttt cttgatttca gggccgtgtt atctaaacaa gatgatttta 1190161 aacatttccg aggaattgcc cagcaaggcg gagatgttat ctttcaatac ttagaacagc 1190221 caagaagctg aaggtttctc atacgtgaga agccttttta tcatatatga cagaacacaa 1190281 gccttttatt acagctgtct gtaacaggtg taaataaaat gtaaagtacc aaagatggat 1190341 aaacatgttt taatttaaca atatttatag aatttcagac tgtttttttg ccattaagca 1190401 gtgagtcatc ctctttattc catcctgata cctccttggg agagttggaa aatctttttc 1190461 cgtgaaaatg aatggatctc ttgttaaggt tatgaagtgt tttttggagc actttaagga 1190521 ggaaactgta tgacaacgaa attcactgct ctggctgttt ttcttctttg tttcatgcct 1190581 gcagccaaaa ttgagcatac acaagcttca ctactgagcg caaagaagac aaaacatgaa 1190641 gaagcgaaat ggcttacaca tatagatcga aatacgaatg aatctttccc ttcactgtct 1190701 gctgataaag acaagaaaat aaaaccgatt aagctatcag cacacactga aaagaaagag 1190761 aaagataaac cggacaaaac aaatgatgag aaagaaacat atacacagtc tgaaaaagag 1190821 ttgctgtccc gtctcgttca cgcagaggcc aaaggagaat catataaagg caaggtcgct 1190881 gtagcaagcg ttgtactgaa caggacggag aaaaaaggtt ttcctgatac gataagagga 1190941 gttatttatc agaaaaacgc ctttgaaccg gtcgcaaacg ggagcattaa ccaaaagcct 1191001 gataaagaat cgattgaagc tgccgaagaa gcgctgtcct caaaaaatag agaaacagat 1191061 gccatattct tttataatcc gaaaacagcg tcagataatt ggattcgttc aagaaaaatc 1191121 gtagaaaaaa tcggcagaca cgtttttgcc gtctaagcat agaagagaca atttgtctca 1191181 gctgtgcttt ttttcatata aagagtaaaa ataaaataat ttttgaactt gtctcatatg 1191241 atgttggtag tacaagagac aaggagagac atcatgaatc gatttgtgaa agggatcatt 1191301 cttttatcca ttgccgcctt tttcgctgaa tgccttgaat ttgtcgtcaa tatgattttg 1191361 gcgcgggagc ttggcgagca tgggatgggg ctttacatga gtattttgcc cacgatcttt 1191421 ttaattattg tcatcgcgag cctggaactg ccgatatcca tttctaaatt cattgccgag 1191481 tcaaatccta agcttcatga aagcatgctg aggcacgctt tcagaatgac agccattttt 1191541 actgcttttt ctactgccgc cgctagtatt gcgcttccgt ttattccggt atttgataca 1191601 taccacccgt ttattaaagg gattgtcatc ggcttaattc ctgttgtcgc ctttacttca 1191661 atcgccaggg gctactttat gggtgtgcag aaaatgggga agatcgcaat tgccaatgtg 1191721 ctgaaaaaaa tcatccagct cttgtgctta ttcctctttt ttcaatggta ctcatttgaa 1191781 ttggacatgg ctgtgctgat ttccttgttt gttctagtcg tgagtgatgt ggtcgtgctt 1191841 gtttatttat attcacaatt tatcatggca aggcgggcgt tatccggcca gcagcacatt 1191901 catttgcgcg gaaaggatgt aaggaaaaga ctgcttgctg tttcaattcc tacaacagga 1191961 ctgcgtattt ttcatgcggt tgtcaatgca attgaaccct ttttagtaaa aggagctctt 1192021 ttggctgcgg gcgttgccgg gacagcggcg atcgatcaat acggaatgct ggcaggagtg 1192081 gctgtgacga tagggtcgtt ccctgctttt attgcccatt cgttaatggt cgtcatgata 1192141 ccgagtattt cggaagctta tgcactttct cagtatgaca tcgtgttaaa aaggctgaag 1192201 cagtcgattt tcattacatt aggttacggt atacctgccg tctgggtcat gttccagttt 1192261 gcgggacctc tcacgcattt gttttttcac tctcctgaag cgcagtatta cttgcagctg 1192321 ttgtggcctt actttctctt tcatctgttt gtcatgccgc tgcaggcgtg cttaatcggg 1192381 atgggttttg tgaaagaggc tttttatcac aatgtatgga gccatatcgt tgcgctaagt 1192441 atgatgtatg tactgggatc aatggagaat ctgcaaatgc tcgggattat ccttggaatg 1192501 aacactggca tgattctttt gacgagcctg cactatgcca cgatctgcaa agcattgaag 1192561 gtatctgtat ttcttacggg agggaccaga acgccgcgaa ttgaaggatg ataaaggaac 1192621 agcaggggca agctaattga aaagcatgaa aggaagattc catgttgacg aagcgcttgc 1192681 ttactatata cattatgtta ttagggttga ttgcatggtt tccaggtgcg gcacaagctg 1192741 aggaaaaaca gcctgctgtt cccgctgttt ttcttatgaa aacgatagaa ggggaggaca 1192801 tctcgattcc gaataaaggg caaaaaacaa ttctccattt ttggacgtca tggtgcccgc 1192861 cctgcaaaaa ggagcttcca cagtttcaat cgttttatga tgcccatcca tccgacagtg 1192921 taaagctggt aacggtgaat ttagtgaatt cggaacaaaa tcagcaagtc gttgaagact 1192981 ttattaaagc aaacaagctg acgtttccga ttgtccttga ctcaaaaggg gaattgatga 1193041 aggagtatca tatcatcacg atcccaacat catttttgct gaatgaaaag ggagaaattg 1193101 aaaaaacaaa aattggcccg atgacagcgg aacaactgaa ggaatggacg gaagaatagc 1193161 tgagagcata gactctcagc ttttttcata tagagaagaa gtgaataaac attaatgata 1193221 attattatca aaaagaaatt aaaataatta taattgaaat tctcttcgtg cgtgctataa 1193281 taaaggaaga catcaagaaa taactgacga taaagctgcc ttttgggcag cgattttgtt 1193341 tttataagag aaatgaagat gatttacgtt ctcaattaga gaggagaatt cgatatgaat 1193401 gaacaagtta tcgttcaacg cgacccgcat gagccattga aaacagacaa gagggaaaaa 1193461 aactgggcac agcacgcgga gcttattgca gcacttgtat caggcgctct tattttggca 1193521 ggctggctct tatccggata tcaggtatta tccataatac ttttcttgct ggcttttgtg 1193581 atcggcggat ttgctaaagc gaaggaagga atcgaagaaa cactcgaatc caaaacgctg 1193641 aatgtagaac ttttaatgat tttcgctgcc attggttccg ccttgatcgg atactgggca 1193701 gagggtgcta ttttaatatt tattttttcc ttaagcggag ctttagaaac atacacgatg 1193761 aataaaagca gcagagattt aacgtcttta atgcagcttg agcctgaaga agcgacattg 1193821 atggtcaatg gtgaaaccaa aagagttccg gtttcagact tgcaggccgg tgatatgatt 1193881 gtgatcaaac ctggagaacg cgtagcggca gacggtatca ttgaatcggg ctcgacaagt 1193941 cttgacgagt cggctttaac aggtgaatca atgcctgtag aaaaaaacac aggcgacact 1194001 gtattcacag gaacggtgaa tcgcaatggc tccttgacag tccgtgtcac gaaagcaaat 1194061 gaagattcgt tattcagaaa aattatcaaa ctggttgaat cagcgcaaaa tagtgtttca 1194121 cccgcgcagg ctttcatcga acgatttgaa aatgcttatg tgaaaggtgt gctaattgcg 1194181 gtggcgctcc ttttattcgt cccgcacttt gcgctgggct ggagctggag tgaaaccttc 1194241 taccgcgcaa tggtgtttat ggttgtcgcg tcaccttgtg cgcttgtcgc ctctattatg 1194301 ccggcggcgc tgtccctgat ttcaaatggc gcccgcaacg gtatgcttgt gaaaggaagc 1194361 gtctttcttg aacagctggg ctcagtgcaa atgatcgcct ttgataaaac cggaactgta 1194421 acaaaaggcc agcctgccgt agagacgatc agaatagcag aaggattcag tgaagcggaa 1194481 gttcttgagg ctgtctatgc catcgaaacg caatcaagcc atccgctcgc ccaagccata 1194541 acggcgtacg ctgaaagccg cggcgtgaat cagtccggct acatatctat agaagaaacc 1194601 tcagggtttg gcgttatggc agaagtgtcg ggtgcgaaat ggaaggtcgg taaagcaggt 1194661 tttatcggcg aggaaatggc agcacaattt atgaaacaaa cagcatcaga tgtcattcaa 1194721 agcggtcata caattgtatt tgtgaaaaag gatgatcaaa tagcaggctg tatcgcactg 1194781 aaggaccaaa tcaggcctga agcaaaagag gtcatggaag aactgaaccg acttgggatt 1194841 aaaacggcca tgctgacagg agatcacgaa gacacggctc aagcgattgc caaggaagcc 1194901 ggcatgacaa ctgtcgtggc agaatgcctg cctgaccaaa aagtgaatga aatcaaacgg 1194961 ttaaaagaag aattcggaac gattgcaatg gtgggtgacg gaatcaatga tgcgccggca 1195021 ctcaaagcag cggatgtcgg cattgcgatg ggcggcggaa cagatgtagc acttgagacc 1195081 gctgatatgg tcctcatgaa aaacgatttg aaaaagctcg taaacatgtg ccgcttgtct 1195141 cggaaaatga acaggatcat caaacaaaat atcgtgtttt ctctagctgt aatctgcctg 1195201 ctgatttgtg caaacttttt gcaggcgatg gaattgccat ttggcgtgat tggtcatgag 1195261 ggcagcacga ttttagtcat actaaacggt ttaagactcc taaaataaaa ccagcagcct 1195321 aatcaggctg ctggcttttt atgtatcaag ctttcccttc atttttgtct ttatcagatc 1195381 ttttcataac taggatgaga gcgagggtgc agcaaaggaa acccgctgca cagcctatga 1195441 tagagctgta ataataaaag cccaccatct tcatcccgat aaaaggagcg gaaattccca 1195501 aaaccgttaa gagcataact gcttttcgtc tgaaaaaatt catcagcaaa cggaacaacc 1195561 cccctgcgat tgaacgttac tgtcagtata caggaagagg agcaggaaat aaaatgcatt 1195621 agaaaatgaa ggcgtcgtga aaggcaaaca ccggtaaaac ctgttacaat ggaagacaga 1195681 acaatgcatt gcaaatggca gggaggaaca agaagtgaat agaatacaac gcgtctcttc 1195741 atggctgaag gaagcggggc atactgccgc atttattcat acgaaagaaa atgtttttta 1195801 cttaaccggt ttttacacag agccgcatga aagattaatg gggttattta tttttcaaga 1195861 agaggagcct ttctttgttt gtccaggaat ggaagcagga caggcccgca acgcaggctg 1195921 gaatcatgaa atcattggct atgcggatca cgaaaatccg tgggagctga tagagaaggc 1195981 tttgaaaaag cgaaatatca gcatacatat gcttgcggta gaaaaggatt caatctcgct 1196041 gtcacgtgca gaacagctga agcatgcgac gggcggggct caatttgttt cagcagaaga 1196101 aacactcaat caatttcgcc tgattaaaga tgacaatgag attcgtttgc tgaaagaggc 1196161 ggcaaagctt gcagattacg gtgttgaagt cggcacagcc gctttgcgtg aaggcatcag 1196221 tgaagtggaa gtgctcgctc aaattgagta tgagctgaag aaaaaaggaa ttcagggcat 1196281 gtctttctct acaatggttt tattcggaga aaaatctggc cagcctcatg gaaatcctgg 1196341 tacagccacg ttgaagaaag gtgattttgt tttatttgat ctcggtgtta ttcttgatgg 1196401 ctattgctct gatattacaa gaacgtttgc atacaaaacc atcaatccga agcaggaggc 1196461 catttacgag actgtgcttc aagcggaaaa agccgcgatt gaggcaagca aacccggtgt 1196521 gagaatcgga gatctggatt taactgcccg cggaatcatt gaaaaagcgg gatatggtga 1196581 ttattttcct caccggcttg ggcatggact cggaatttca gtccatgagt atccatcaat 1196641 gagccaggcc aacgatacac tgctgcagga aggcatggtc tacacgatcg aaccggggat 1196701 ttatgtgcca gagatcggcg gcgtacgcat tgaggatgac gttcacgtaa caaaggacgg 1196761 agcagttgct ctgacccaat atccaaagga tttgatcata ctgtaataga aataaaaaag 1196821 gactttgttc tcgacatcgt ccttttttat ctgcattaaa taaaaaaatc atcaaatgtt 1196881 cgaaagggtt taatttcatg tttttggttg agaggtttta cagcaagaca gctgccaccg 1196941 agaacagtga gacataaccc aattaaaatg aagaaaccca tgtgatcttc tcctttcagc 1197001 taaaaacaca aaaagatatc tggtacgtcc atatcatatt gtatgaaacg cattccagat 1197061 caaggggatt tagaaagaag ggaatctatg gctaatatta aagacattgc agagaaagcc 1197121 ggtgtctctg ttacaacggt ttcccgagtc ataaacaatc atccatacgt cagtgaagac 1197181 aaacgaaaaa gagtgtttga ggcaatggaa tcattggagt acacgagaaa tattcacgct 1197241 gtacatttgt cgaaaggatt ttcaaacatg attggtgttg tcttgccgac ggttaatctg 1197301 ccatattttg cagagctgat tgcaggaata gccgacgcag ccgcggaatc cggggttcac 1197361 ctctctttat tccaaacaaa ctatgaagta caaaaagaaa tctttgcgct gtcccaatta 1197421 aagcagcgcc aggttgacgg cctgattttt tgctcaaagg cgcttgctga tgagaaactc 1197481 atggaatggg agggcccgat tttgctttgc cagaattcag ataatgcccg cttcccaacc 1197541 atcagcattc ctcaccaaga agcatttcgg aacggcttgg actatttaat tgccaaaggg 1197601 cacaaaaaaa tagccatctg tttggcaaga aaaaaaggca tgaacagcca ttttcgaatc 1197661 aaagcctaca aagaggcatt ggaagagatc ggcgaggcat ttcgtgaaga ctgggtaatt 1197721 gagaaagcga ttacaatcaa tgatgggaag gcgctttttc ataaatggaa tacgtggaag 1197781 gaaaagccga cggctatttt tgttgccaat gaccaagtct cagcagggct ttttcttgaa 1197841 gcaaagaacc agcgggtgtc agtaccggat gagcttgcaa tcttaagcgt tgataaccac 1197901 gaaatcagcc aagcgcttgg aatcacaacg atcgatattc agacaaggga aatgggaaag 1197961 caggcatttg ccatattgga aaaaagaatt caaggacagc cgattgaaag gaaagttctg 1198021 gattaccgtc tcatcgaaag atcgactgtt tagtgaatgc attgaaaaaa ggtttgacgt 1198081 gcattctgtt cgttatgtac gatatgaggt attgaatgac aaaggagctg aggatcgtga 1198141 atgggtcctt cacagtgaaa aaggtactga ataataacgt attaattgct tctcatcata 1198201 aatacagcga agtcgtttta atcggaaaag gtattggttt cggaaaaaaa caagatgatg 1198261 tcattgaaga taaaggctac gataaaatgt tcattttaaa agacgagaag gaacaaaagc 1198321 agtttaaaaa gctccttgac tatgttgatg aaaagctcgt tgatatttca aacgatgtca 1198381 tctatcacat aagcaatagg acgaatcact cattaaatga acatattcac attgcgttga 1198441 cagaccatat cgcatttgcg atcaaaaggc agcagcaggg atttgatatg aaaaatccat 1198501 ttctaatgga gactcagtca ctatatcctg aggagtacca aattgccaaa gaagtcatag 1198561 atatgatcaa tgaaaaagcg ggactctgcc ttccggaagg ggagattggt tttatcgctc 1198621 tgcatatcca ttcagcgttg acaaaccgtc cgctgtccga ggtcaatcag cactctcagc 1198681 tcatggcgca gcttgtcgag gtgattgaag actcatttca aatgaaagta aataaggaaa 1198741 gtgtcaacta tttgcggctg atcaggcata tcagatttac aatagaaaga attaaaaaag 1198801 aagaaccgac taaagaacca gaaaaattaa tgttgttatt gaaaaatgaa tatccgctat 1198861 gctacaatac agcttggaaa ttgattaaaa tcttgcagca aacattgaag aaaccagttc 1198921 atgaggcgga agcggtttat ctgacgcttc atctgtaccg attaaccaat aaaatttcat 1198981 aaattcagtt tatccttata acgtgttact gattcgatca ggcatgagtg attgagggaa 1199041 aaaaacggga agttcattct cgttcttttg cgcacccaat tttgctcatg cctttttgtt 1199101 gtgtaaaagg gcaaatgtaa acggttaaac tggaagactt acgcctgtga attcgttgtc 1199161 atgattttta gctgtaaggt cagactagta aaaagaggag gtcaattctt atgtttaaag 1199221 cattattcgg cgttcttcaa aaaattgggc gtgcgcttat gcttccagtt gcgatccttc 1199281 cggctgcggg tattttgctt gcgatcggga atgcgatgca aaataaggac atgattcagg 1199341 tcctgcattt cttgagcaat gacaatgttc agcttgtagc aggtgtgatg gaaagtgctg 1199401 ggcagattgt tttcgataac cttccgcttc ttttcgcagt aggtgtagcc atcgggcttg 1199461 ccaatggtga tggagttgca gggattgcag caattatcgg ttatcttgta atgaatgtat 1199521 ccatgagtgc ggttcttctt gcaaacggaa ccattccttc ggattcagtt gaaagagcca 1199581 agttctttac ggaaaaccat cctgcatatg taaacatgct tggtatacct accttggcga 1199641 caggggtgtt cggcggtatt atcgtcggtg tgttagctgc attattgttt aacagatttt 1199701 acacaattga actgccgcaa taccttggtt tctttgcggg taaacgtttc gttccaattg 1199761 ttacgtcaat ttctgcactg attctgggtc ttattatgtt agtgatctgg cctccaatcc 1199821 agcatggatt gaatgccttt tcaacaggat tagtggaagc gaatccaacc cttgctgcat 1199881 ttatcttcgg ggtgattgaa cgttcgctta tcccattcgg attgcaccat attttctatt 1199941 caccgttctg gtatgaattc ttcagctata agagtgcagc aggagaaatc atccgcgggg 1200001 atcagcgtat ctttatggcg cagattaaag acggcgtaca gttaacggca ggtacgttca 1200061 tgacaggtaa atatccattt atgatgttcg gtctgcctgc tgcggcgctt gccatttatc 1200121 atgaagcaaa accgcaaaac aaaaaactcg ttgcaggtat tatgggttca gcggccttga 1200181 catctttctt aacggggatc acagagccat tggaattttc tttcttattc gttgctccag 1200241 tcctgtttgc gattcactgt ttgtttgcgg gactttcatt catggtcatg cagctgttga 1200301 atgttaagat tggtatgaca ttctccggcg gtttaattga ctacttccta ttcggtattt 1200361 taccaaaccg gacggcatgg tggcttgtca tccctgtcgg cttagggtta gcggtcattt 1200421 actactttgg attccgattt gccatccgca aatttaatct gaaaacacct ggacgcgagg 1200481 atgctgcgga agaaacagca gcacctggga aaacaggtga agcaggagat cttccttatg 1200541 agattctgca ggcaatgggt gaccaggaaa acatcaaaca ccttgatgct tgtatcactc 1200601 gtctgcgtgt gactgtaaac gatcagaaaa aggttgataa agaccgtctg aaacagcttg 1200661 gcgcttccgg agtgctggaa gtcggcaaca acattcaggc tattttcgga ccgcgttctg 1200721 acgggttaaa aacacaaatg caagacatta ttgcgggacg caagcctaga cctgagccga 1200781 aaacatctgc tcaagaggaa gtaggccagc aggttgagga agtgattgca gaaccgctgc 1200841 aaaatgaaat cggcgaggaa gttttcgttt ctccgattac cggggaaatt cacccaatta 1200901 cggatgttcc tgaccaagtc ttctcaggga aaatgatggg tgacggtttt gcgattctcc 1200961 cttctgaagg aattgtcgta tcaccggttc gcggaaaaat tctcaatgtg ttcccgacaa 1201021 aacatgcgat cggcctgcaa tccgacggcg gaagagaaat tttaatccac tttggtattg 1201081 ataccgtcag cctgaagggc gaaggattta cgtctttcgt atcagaagga gaccgcgttg 1201141 agcctggaca aaaacttctt gaagttgatc tggatgcagt caaaccgaat gtaccatctc 1201201 tcatgacacc gattgtattt acaaaccttg ctgaaggaga aacagtcagc attaaagcaa 1201261 gcggttcagt caacagagaa caagaagata ttgtgaagat tgaaaaataa gggtgttagt 1201321 acgccgtgct tgtcagatga caagtacggt tgtatgatat aatattgtga agtaataaag 1201381 ctttaagtta aaaggagaat gataaaaatg gcacaaaaaa catttaaagt aactgcagat 1201441 tctggaatcc atgctcgtcc tgcgacagtt cttgtacaaa ctgctagcaa atacgacgct 1201501 gacgttaatt tagaatataa cggcaaaaca gttaacctta aatctattat gggtgttatg 1201561 tctttaggta tcgctaaagg cgctgagatc acaatctctg cttccggagc tgacgaaaac 1201621 gatgctctta acgctttaga agaaacaatg aaaagcgaag gactcggcga gtaatgcaag 1201681 aattaaaagg gattggtgct tcagccggca tcgcgattgc aaaagcgtac cggcttgaag 1201741 agccagattt aacggttgaa aagaaaaaca tctctgattc tgaagcggaa gtaagccgtt 1201801 ttgatgaagc gattgcacgt tcaaaagaag agctcgaaaa aatcaaagag cacgctttga 1201861 aagaactggg tcaggataaa gctgatattt tttctgctca ccttttagtt ctcagtgacc 1201921 ctgagcttct gaaccctgtg aaagaaaaaa tcagcactga ttcagtgaac gctgaattcg 1201981 ctttaaaaga aacgtcttct atgttcgtta ctatgtttga atctatggac aacgaatata 1202041 tgaaagagcg tgcggcagat atccgcgatg taacaaaacg cgtaaccggc cacctgcttg 1202101 gcgtcgaaat tccaaaccca agcatgatct cagaagaggt tattattgta gctgaagact 1202161 taacaccgtc tgacacagct caattaaacc gtgagttcgt aaaaggattc actactgata 1202221 tcggcggacg cacatctcac tctgccatca tggcacgttc tcttgagatt ccagcagttg 1202281 ttggaacgaa agctgctaca ggcacgatcc aaaacggcgt gactgttatc gttgacggta 1202341 tcaatggcga tgtcattatt gacccatctg cggaaactgt aaaagagtat gaagaaaaac 1202401 ataatgctta tttggctcaa aaagctgagt gggcgaagct tgtcaatgaa ccgactgtct 1202461 caaaagacgg acatcatgta gagcttgcag cgaacatcgg tactcctgat gatgtaaaag 1202521 gtgttcttga aaacggcgga gaagcagttg gcctttaccg tacagaattc ctttacatgg 1202581 gaagagatca gctgcctaca gaagatgagc agtttgatgc ttacaaaacg gttcttgagc 1202641 gtatggaagg aaaatcagtc gtcgtgcgga cacttgatat cggcggagac aaagagcttc 1202701 cttacctgca gcttcctaaa gaaatgaacc cgttcctggg atatagagcg attcgtcttt 1202761 gccttgaaga gcaagaaatc ttcagaacac agcttcgcgc gctgcttcgt gcaagtacat 1202821 acggaaactt gaaaatcatg ttccctatga ttgcgacagt taacgaattc aaagaagcaa 1202881 aagcgatcct tcttgaagag aaagaaaagc tcgtaaaagc gggacaggct gtatctgacg 1202941 atattgaagt cggaatgatg gttgagattc cgtcaactgc agtcatcgct gatcagtttg 1203001 ctaaagaggt tgatttcttc agtatcggaa caaacgattt gattcaatac acaatggcag 1203061 ctgaccgtat gaatgaacgt gtatcttacc tgtatcagcc atacaacccg gcaatccttc 1203121 gcttaattac actggtaatt gaagcagcac acaaagaagg aaaatgggtt ggcatgtgcg 1203181 gagaaatggc aggagacgag attgcgattc cgatccttct cggcttaggc ttagatgagt 1203241 tctcaatgag cgcaacgtct atccttccgg caagaacaca aatcagcaaa ttgtctaaac 1203301 aagaagctga gtcattcaaa gagaaaatct tatctatgag cacgacagaa gaagttgtcg 1203361 cgttcgtaaa agaaacattc aagtaatgta caaaaaccag acggcctccg gcctgtctgg 1203421 tttttttcat aagtaagggt atagaaggac acaataacat ggctaggagg gatagtatgt 1203481 caaaccaatt taacgcagga gatactgttt atgtgatcta cagaaatccg cacgccgcca 1203541 atgtagccca cataaaggaa gccgaaattg tgcaccatcc ataccatgaa ggcgagcttt 1203601 ccctgtttat ttatgaaacc tatcatccat tcgcagagga cgatgctgtg tttgcaagct 1203661 atgaagaagc taaatcgctt tacaaagaac tgtttgatat tgatccgtat gagtaacaag 1203721 gaaatcatta caactcatat cctttccgcc tagtgagaaa agtaacgtta gtaaaggaaa 1203781 aggatgtggc atcatgcaga acccatttgt tccgcagctt gtgtatatag aaccgagggc 1203841 gctggaatat ccgctgggcc aagaattaca agataaattt gagaatatgg gtattgaaat 1203901 cagagaaacg acatcccaca atcaggtgcg taatatccct gggaaaaatc atcttcagca 1203961 atatcgcaat gcgaaatcaa ctttagttat cggtgtccgg aaaacattaa agtttgattc 1204021 atccaaaccc tcggccgaat atgccattcc gtttgcaaca ggctgcatgg ggcattgtca 1204081 ttactgctac ctgcaaacaa ccatgggatc aaagccgtat atcagaactt atgtaaacgt 1204141 cgaagagatt ttagatcagg cagataagta tatgaaggag cgcgcaccag agttcacaag 1204201 gttcgaagca tcatgtacgt cagacattgt aggaattgat catctgacac acacgctgaa 1204261 gcgcgccatt gaacattttg gccaaagtga tctcggaaag ctccgatttg taacgaaatt 1204321 tcatcatgtc gatcacctat tagacgcaaa gcataacggg aaaacgagat tcagattcag 1204381 tattaatgcc gactatgtga ttaaaaactt tgagccggga acttcacctc ttgataagcg 1204441 gatagaagcg gcagtaaaag ttgcaaaagc aggctacccg ctaggcttta ttgttgctcc 1204501 gatttatatt catgaaggct gggaagaagg atacagacat ctgtttgaaa agctagatgc 1204561 tgctttgccg caggacgtta gacatgacat tacgtttgaa ttaattcaac accgttttac 1204621 aaaaccggcc aaacgagtga tagagaaaaa ttatccgaag acgaagctcg aattagatga 1204681 agaaaagcgc cgttataaat ggggccgtta cgggatcgga aaatatattt atcagaaaga 1204741 tgaagagcat gcacttcgag aggcacttga atcctatatt gatacctttt tccctaacgc 1204801 aaaaattgaa tatttcactt aaacgggctg ttgtgatcaa cagctcgctt ttttataaaa 1204861 aacatttttc cattccatca aaacgccgta attcaatgat tctttatcct ccaaataatt 1204921 gctgactaca cgaataggtg aacgcccgca acggaggaga aaggacagca cagggtcgtt 1204981 tttcctgcct tccatcacat cttcaacgta ctgaacagcg ctgatctcgt gtgcgtattt 1205041 ataatacaaa ggaatgcggc cgccgccgag aaggcgttcc agtcttttat caacagtcag 1205101 ctcatacatc gtattcatca gccattttcc gattccaagc tttcgataat gaggagaaac 1205161 agaaatatcc actacatata aagtatttcc atgaggttca tgatttttaa tcgatccgtt 1205221 gtcagttgct tgtgcccatg tatgatcagg agaatcaggc tcaaattgta caataagagc 1205281 agtcatggaa ccgataattc tgccattgat gagcgcgcat aaagcgcctt ccggaaaggt 1205341 tttgatatgg ctggcaagct ggtcctctga ccacagcaat tcctggggaa acggaggagg 1205401 gaaacattct tcttgaagag aaatcagcct ctcgatgtca gtctcagtgt agtttctaat 1205461 ggtcagagcc tcaaattttc tgccgtcatg cacatacatt tgttttagta tgatcatcac 1205521 tctccttatg ttgtttcatt ataacgaaga ttgaattttc agtaaatata ttccgatttt 1205581 cttataattt attttttgat tattcatttt tcaaacgaaa gggccgatat agaaattagg 1205641 aggggattgg tttgtttaaa aaacttcaca tgaagattgc tgtttttgtt tcgattatgt 1205701 taatcatcac agttgttctc ttaatgctgt cttcttattt gacgctaaaa ccgatgatta 1205761 cagaggatgg gaaaaataca actcaaaacg tgacgcagtc acttgaacaa aatattgaat 1205821 tgcaattaaa gagttatgcc atttcgttat caagattggc taatggggaa ttaacgcata 1205881 catttgtaac gaaaccaagt aaagaagctt ctcggctgtt tcacgatgac attaagcaaa 1205941 tcaaagacaa cgatgattat gttgcgatgg cttacatagg caccgcaaaa aaagaaatgt 1206001 ttacatatcc aaaagcggat ttcgctgagg attacgatcc aacatcaaga ccatggtata 1206061 agcttgcagc tgaaaccccg gatcaagttg tttggacgga accttataaa gatgtcgtga 1206121 caggagacat gattgttact gcatcgaaag cgatcttaga caggcaaaaa gtgatagggg 1206181 ttgccagcta tgacttgaaa ctctctgcta tccagagtat ggtcaataaa caaaaggtgc 1206241 cttacaaagg atttgccttt ttagctgatg cgagcggcaa tcttttagcc catccgtcaa 1206301 atcaaggaaa aaatatatca aaggatcaaa cactgcaaac catcgcatcc gagaaaaaag 1206361 ggatacaaga tgtgaatggg aaaatggttg tgtaccaaac gattggcgag acaggctgga 1206421 aggtcggaac gcaatttgat accgatcaat taatgtggat ttcagataaa atgaatcggg 1206481 ccaatctttg gatatcattg attgcgctta tcataacaat tattctcagc tacttcctgg 1206541 ccaaaacgat aaccggtccg atacagcagc tgatcgtaaa aacgaaagct gtttccgcag 1206601 gcgatttaac agtgcgcgcg gaatcaaaat ctaaggatga agtcggtatt ttaacaagag 1206661 atttcaatct gatggttgaa aatatgaagg aaatggttga gcaagtgaga ctctcttcag 1206721 ggaaagtatc tgacacctct gaacaactaa cggctgtggc tgccgaaact aatgaaacaa 1206781 gcggacaaat tgcaaaagcg attgaagaag tagccgcagg ggcatcggaa caggcttctg 1206841 aagttgaaac cattaatgaa aaatcggaaa gcctgtcaac gaaaatcagg caaatcgctg 1206901 aggaggcagg cggaattaaa gaacgctcaa aatcgtccga ggatgcaagc tataaaggac 1206961 ttgacgcgct cggccagctg ctgatgaaat caaacgaagc caatatggaa acgaaaaagg 1207021 ttgaaacgat gctgctggat ttggaaaatc aaactaagaa tattgaagaa gtcgttacag 1207081 cgatttcaaa catatctgat caaaccaact tgcttgcctt aaatgccagt attgaggcag 1207141 ccagagccgg agaaagcggg cgcggttttg ccgtcgtagc cgatgaagtg cggaagttag 1207201 ctgagcaatc agccctttct acaaagcata tcagcgagac tgtgaagctt atccagcttg 1207261 agacaaaaga ggcctctcac gcgatggttg aggcaagcag aatgaatgat gaacaaaaca 1207321 gtgcaattca cgaaactgga gaggtattaa atacgataac tgcagaaatg cagtcactgg 1207381 tacaaggtat tgatcacatt tacgcggaaa ttcaaagaat gagtgaagaa cagcttgcga 1207441 tttctgaagc cattcaaagc atttcagcca tatcacagga atcagctgcc gcagcagagg 1207501 aagtgaacgc atcaaccgat gaacagcttg tcacccttga taaagtcaaa cactcaacgg 1207561 aaacactaaa acatgcaagc caagagctta tgaacacaat tgcaaaattc acattgtaat 1207621 ccaattacat ccccaaacat catttgtttt ggggattttt tattttataa gatgaataga 1207681 tatggtagtc tagaaaatga aggaaaaatg ataaatttta actaaaatct aaacgaaaca 1207741 tctgggagga atgaccttga aaaaaacaat tggttttatc ggtcttggag taatgggaaa 1207801 aagcatggca tcacatattc tcaatgacgg ccatcctgta ttggtgtaca cccggacaaa 1207861 agaaaaagca gaaagcatac ttcaaaaagg cgcgatctgg aaagatacgg tcaaagatct 1207921 ttcgaaagaa gcggatgtta tcatcacaat ggtcggctat cccagtgatg ttgaagaagt 1207981 gtatttcgga agcaatggaa ttattgaaaa cgcaaaagaa ggtgcatatc ttattgatat 1208041 gacgacatct aagccttcgc ttgcgaagaa gattgctgaa gcggccaaag aaaaagcatt 1208101 gttcgcttta gacgctcctg tttccggtgg agacatcggt gcacaaaacg gaacactcgc 1208161 gattatggtc ggtggagaaa aagaagcttt tgaagcctgc atgccgattt tctctttaat 1208221 gggagagaat attcagtatc aaggaccggc tggaagcgga cagcatacca agatgtgcaa 1208281 tcagattgca attgcagccg gtatgatcgg tgttgctgaa gcgatggctt atgcccaaaa 1208341 atcaggccta gagccggaaa atgttctgaa aagcatcaca acgggcgcag ccggaagctg 1208401 gtcattgtca aatcttgctc cccgtatgct gcaaggcaac tttgaaccgg gattttatgt 1208461 gaagcatttt attaaggata tgggaattgc actagaggaa gcagaattaa tgggggaaga 1208521 aatgccaggc ttgtcgctcg caaaatcttt atatgacaag ctagctgctc aaggtgaaga 1208581 aaacagcgga acacagagta tatataagct ttgggtgaaa taaaaaaaga ttgcctgtac 1208641 gaaacaggca atcttttttt attattttcc gatgaattgt tgtgtccaga tgcttccaga 1208701 ctcaacgtaa ccaacaccga tgtgagtaaa gttagggttt agaatgtttt ttctgtgtcc 1208761 ttcactgttc atccaagctt ttactacttc ttctggtgtc ttttggccct tcgcaatgtt 1208821 ttcacctgct gttttgtagc tgattccgaa agatttcatc atatcaaacg gtgagccgta 1208881 tgttgggctt tggtgatcaa agtagttttt gtctttcata tcctgagatt ttgcgcgtgc 1208941 agatttgctt aacgtttcat caatttgaag cggttttaag ccttgttttt gtctttctgc 1209001 atttgtaagt tcaacaactt ttttctcata tgcacttaca gatgaaggtg cagacgttgt 1209061 tgtgtttgtt ttttcagcag ttgcgggtgc tttagaagca gtgttttgat cagcagctgc 1209121 tttttcagta gtcttttgtg caggttttgc cgtttctgtc ttttgaacat cctgaacttt 1209181 cacgttagat tgcttcgcat gtttttgaag aagctgcttc atctcttttt cgtttgcagc 1209241 gtttaacgtt ttgatatttg tgttaatatg cagttttttc actgcatcgt taagtgacat 1209301 gttttgtact gtgttccccg tttttactgt aaccacaggc tggcaggaga gttctttcgc 1209361 tgatgcttgc tgtacgcccc cgaatgtgaa taatccaacc gcagcggcag cagataaaat 1209421 aaatgctttc ttcattagtt cgtaacctcc tagagttgtt tgtttctaca gaaaaatcat 1209481 aacatagctt ttttgtcata aagattccag cactttcctt tgacaaatag agattgtcat 1209541 tttcgtaaag taaatccgtt gaatcactaa gaataaggga atcagcggta tatatgattt 1209601 tatcgtaccg ttacatagct tccttttttt tgaaccgtta gttatatttt aatgtgtttt 1209661 tatattgaca gcttttttta ctccttttcg ctgtaacaac tattacaaag gtgttacaat 1209721 taatctcagt atatgtaaat atattgaatg atttgagagg ggtaaccaga agtgactgaa 1209781 ataggacgtg aaccaaagaa aaagagcaaa ggaaacagag caatcagaat gaaccttttt 1209841 ttcctagctg tctttgttct attcactgca ttaattttta agctcggggt tgttcaaatt 1209901 gttgaaggcg aacagcatga agaagacgct gagaaatcaa atgcaaaaac agcttactat 1209961 cctgcgcctc gcgggaagat gtacgacaga aaccagaaag ttgctgtcga caaccagagc 1210021 gttccagaaa ttgtgtatgt atcaacatct agcacaaaaa cagaagataa aatcaaaaca 1210081 gcgaagcggc ttgcttcttt cattcatatt gataccgaat ttttgaagga aagggatctt 1210141 cgtgattact ggatcgcagc tcatccgaaa aaagccgccg ctctgcttaa ggaatcagaa 1210201 agcaatctga aaggagacca ggcttacaag cttcaaatag agcgtgttcc ggatcaagaa 1210261 ttaaaggcta ttcagcaaga tgacgaagaa atggaaactg ctgcgatata tacaaggttt 1210321 tcaagcggaa atgcttacga acctcaaatc gtaaaggcaa tgaatccaaa taagagcaat 1210381 agcaatggaa aaaacggagc gctgcttgat gagaagaaaa actcctcgca aagaccaaaa 1210441 aatgacttaa catatgatga aatttccatt gtttctgagc atttagaaga acttccggga 1210501 atcgatatcg taaacgattg gacacgaaaa tatccttatg acaaaaccct ttattctgtt 1210561 ttcgggggcg tcacgacacc tgatcagggc ctgctgagcg accggaaaga tttctactta 1210621 acaagaggct atgcgaataa tgacagggtg ggaaaaagtt atttagagta tcaatatgaa 1210681 gaatatttaa attcgcataa agaaaaagtg gaatacgtag aagataataa aggaaatgtc 1210741 gtcagccaaa aaaccattga taagggcagc aggggatacg atcttcagct ttcttttgac 1210801 atggagcttc aggcaaaggt agaaaagatc attgaagaag aagtaagaaa cagccgtgca 1210861 cgcggaaatt acatgcttga cagagccttt gccgtaatga tggacccgaa taacggcgat 1210921 attttatcaa tggcagggaa aaagatagat ttaaaaacca acaaaattga agattatgcg 1210981 ataggggcat ttaccaccca atatgaaatg ggatcagcag taaagggggc caccgtgcta 1211041 gccggctatc aggacgggat cccgcattat aaatattata tcgatgctcc aatgctttta 1211101 ggaacgaatc ttataaaaaa atcttatact aatatgggaa ccatcaatga attaaccgca 1211161 ttgcaaaaaa gttcaaacgt atatatgttc aatgttgcca tgcatattgc aggcgtaaca 1211221 tacaagccgc atggatctct cccggctgat cagaacgatc tactgaaaat gagaaactat 1211281 tacagccagt ttggtctggg agtaaagaca ggtattgatc tcccgcagga atcagccgga 1211341 atgcaaacca cacctaaaac tgtaggagga ttaattttag acttagcaat tggccaatac 1211401 gatacataca caccgcttca aatggctcaa tacatctcag taatcgccaa tggtggctat 1211461 cgtgttcagc ctagaatcgt cacaagtatt cataagccag gaaaaaaaga ccagctgggt 1211521 aaggcgattg aacataggaa acctaaagta ctcaataaga ttaataattc agagagcgat 1211581 ttgaaacaag tacaaacagg catgaaatta gtcacttctt cagggacagc aaaaaatacg 1211641 tttacagaag atgtatcagg gaaaacggga acagcggaaa cattttacta cggcacgaat 1211701 cgcaactggt gggggaaaaa aacatacaat ctgacttttg tcggctatta cccgtcgaaa 1211761 aaaccaaaag tggcctttag tgttgttgtt ccatcagtag atgatgatga taagatcaat 1211821 aaaattattg ccaaaagagc tatccacgcc tacgcagagc tcgaaaaaaa acacagtaaa 1211881 aaataaaaaa cagggtgcac aactaaaaga ttgtgtgccc tttcttttat tcaaaaattg 1211941 acgttcacca taagaataga aggagaatac tcattttcta gcgaatcata ctaggtaaaa 1212001 gtcaatctgt atatgtcgaa acacgatgat catgcaaagg agggattctg tggaacagga 1212061 tacgcagcat gttaaaccac ttcaaacaaa aaccgatatt catgcagtct tggcctctaa 1212121 tggacgcatc atttatatat ctgccaactc caaactgcat ttgggctatc tccaaggaga 1212181 gatgatcgga tcattcctca aaacgtttct gcatgaggaa gaccaatttt tggttgaaag 1212241 ctatttttat aatgaacatc atctgatgcc gtgcaccttt cgttttatta aaaaagatca 1212301 tacgattgtg tgggtggagg ctgcggtaga aattgttacg acaagagctg agcggacaga 1212361 acgggaaatc attttgaaaa tgaaggttct tgaagaagaa acaggccatc aatccctaaa 1212421 ctgcgaaaaa catgaaatcg aacctgcaag cccggaatcg actacatata taacggatga 1212481 ttatgaacgg ttggttgaaa atctcccgag tccgctatgc atcagtgtca aaggcaagat 1212541 cgtctatgta aacagcgcga tgctttcaat gctgggagcc aaaagcaagg atgctattat 1212601 tggtaaatcg tcctatgaat ttattgaaga agaatatcat gatatcgtga aaaacaggat 1212661 tatacgaatg caaaaaggaa tggaagtcgg aatgattgaa cagacgtgga aaaggcttga 1212721 tggcacacct gttcatttag aagtgaaagc atccccgacc gtctacaaaa accagcaggc 1212781 tgagctgctg ctgctgatcg atatctcttc aaggaaaaaa ttccaaacca tcctgcaaaa 1212841 aagccgtgaa cgatatcagc tgctgattca aaattccatt gataccattg cggtgattca 1212901 caatggaaaa tgggtattta tgaatgaatc gggaatttcc ctgtttgaag cggctacata 1212961 tgaggattta attggcaaaa acatatacga tcagctgcat ccttgcgatc acgaggatgt 1213021 aaaagagaga atccaaaaca ttgccgagca aaaaacagaa tctgaaattg tcaagcaatc 1213081 ctggttcacc tttcagaaca gggtcatcta tacggagatg gtctgcattc cgacgacctt 1213141 ttttggtgaa gcggccgtcc aggtcattct tcgggacatc tcagagagaa aacaaacaga 1213201 agaattgatg ctgaaatcgg aaaaattatc aatcgcaggg cagctcgcgg cgggaatcgc 1213261 ccatgagatc cgcaaccctc ttacagcgat caaaggattt ttacagctga tgaaaccgac 1213321 aatggaaggc aacgaacatt actttgatat tgtgttttct gaactcagcc gtatcgaatt 1213381 aatactcagt gaactgctca tgctggcgaa acctcagcaa aatgctgtca aagaatattt 1213441 gaacttgaaa aaattaattg gtgaggtttc agccctgtta gaaacgcagg cgaatttaaa 1213501 tggcattttt atcagaacaa gttatgaaaa agacagcatt tatataaacg gggatcaaaa 1213561 ccaattaaag caggtattca ttaatttaat caaaaatgca gttgaatcaa tgcctgatgg 1213621 gggaacagta gacattatca taaccgaaga tgagcattct gttcatgtta ctgtcaaaga 1213681 cgaaggggaa ggtatacctg aaaaggtact aaaccggatt ggagagccat ttttaacaac 1213741 aaaagaaaaa ggtacggggc ttggattaat ggtgacattt aatatcattg aaaaccatca 1213801 gggagttata catgtggaca gccatcctga aaaaggcaca gcgtttaaaa tttcatttcc 1213861 aaaaaaataa aaacaacggc ttaaacgccg ttgtttatcg tctgcattgc ttcacgtttt 1213921 tttaatacaa ataattctaa acggtctagg ccttctctca gcgtgtccat tgagcatgca 1213981 aaagacagcc ttacatatcc ttcaccatat gttgagaacg agctgcccgg cacgagtgcc 1214041 acgccagcgt cttccaaaag agccatacta aaatcaaatg aagtcattcc aaatgattta 1214101 atagaaggga agatataaaa cgcaccggac ggtttaacta cgtcaagtcc catggaaaca 1214161 agacggtcat aaacatagtc cagacgtttt ttgtattgtt ctctcataat caatgcatcg 1214221 tcaaagccgt ttgtgacagc ttcaagcgcg gctttttgag aaatggatga ggcgcacgac 1214281 acattgtatt gatgaacctt taaaatgtgc tttgcaatgt ctttcggtgc aaataaaaat 1214341 ccaattctcc aaccggtcat gctgtgtgat tttgacaacc cgttaatgac aatcgtttga 1214401 tcccgcaaat aggttgcgat ggagtaatgc ggtctgtcat atgttaattc actgtatatt 1214461 tcatcagaca atacgaagac atttctgcct tttaagagag ctgcgatgct tttcagttct 1214521 tcttcagata aagtcacgcc ggtagggttt gacggataag gaagcacgac acacttggtg 1214581 ttgggtgtca gagcatcttc aatcagccgg gcggtaagct taaagccgtg tgacgtagta 1214641 tcaacaatga caggcttggc cccgcacaaa ttgataatag gttcatagcc cggataaata 1214701 ggccctggca taatgacttc atcaccggga gataaaatcg tccggaatgc agcatcaatg 1214761 gcttggcttg cgcctgttgt gatgataatt tcagattcag catcatagtt gaaatccgct 1214821 tttttcttca tataaagctg cacagcttgt ctcagctcca ggtagccggc attcggagta 1214881 tatgacgtca cgttttcatc aatggctttt tttgcggcag ctttcacatg atgcggtgtg 1214941 aaaaaatcag gctggccgat tgtaagtgaa atgacgtctt cgtgttgggc tacaagattc 1215001 gagaatttgc gtattcctga aatttcgatc tctcttgctt tcggattcag caaatgttcc 1215061 ataattcatc accttaacaa atataatgag tttatcctat tttaccacta gctgatcatt 1215121 tgtcaccttt ttaactgata tatttcgatt gtatgcgcct tttttctaaa catacctttc 1215181 ttttcagaaa aaaagaagac aaccagcgat ttgattgtct ttattgtatc atgttctatt 1215241 attgtttata tgtgccaatt tcattaatag ccataatcaa aatgaaggtc ttcgtgccaa 1215301 atcagatacg gaggatgctc ttcttgaagg tcagctgatt ctttcttcat attcaggtaa 1215361 gtttcttcac tgatatcctc taaaacagtc atttcgtttt ctttaaatat tactaaggta 1215421 cccattattt acacccttct ttggaaaaat ccttgactat tttatcactg ttagttggaa 1215481 agtcaatggt tattaggaaa aaagtttctt ttttgaggaa cgcggcttgt tgccttcgga 1215541 attcgatttt gaagagctgc cattcacttt ttacaaatta cgccgatata tacagtacaa 1215601 tactgaatgc gaatagcgag ggattgaatt gtcgttacaa caatacgaaa ttttattgga 1215661 ttctggtaca aatgaattag aaattgtgaa gtttggcgtg ggtgaaaatg ctttcggaat 1215721 taacgtcatg aaggtaagag aaattattca gcctgtcgag gtgacatcag tgcctcactc 1215781 ccatcagcat gtagaaggaa tgattaaact cagaggagaa atcctccctg tgatcagtct 1215841 cttctcattt tttggagtag agcctgaagg atcaaaagat gagaaatata tcgtgactga 1215901 atttaataaa cggaaaattg tttttcatgt cggctctgtt tctcaaattc acagagtatc 1215961 ctgggaagcg attgaaaagc cgacatcgtt aaatcaagga atggagcggc accttaccgg 1216021 tattattaag ctcgaagacc tgatgatctt tttgcctgac tatgaaaaaa ttatttatga 1216081 cattgaatca gattcaggtg ttgacacgta taatatgcat accgagggct tcgatgaaag 1216141 aagaactgat aaaaagctta tcattgtaga ggactcaccg cttttgatgc gcctcttgca 1216201 ggatgaatta aaagaagcag ggtacaacaa tatcgcttcg tttgaaaatg gaaaagaggc 1216261 atatgaatac attatgaacc ttgctgaaaa cgaaactgat ttatcaaaac agattgatat 1216321 gatcatcact gatattgaaa tgccaaaaat ggacggacac aggctcacaa agctgctgaa 1216381 ggaaaatccg aaaagctcag atgtgccggt tatgattttc tcatcgttaa ttacggatga 1216441 tctgcgtcac cgcggcgaag ttgtaggcgc agatgagcaa atcagcaagc ctgagatcag 1216501 tgatttgatt aaaaaagtgg atacgtatgt tattgaataa ataaaaacag ccgttgccag 1216561 aaagaggcac ggctgttttt attttaaaag taactctcgc caagtttttt aaagaccggt 1216621 ttatggtaag ctggctgctg gcgatttggc actagcggct tttctttcat gccgacatat 1216681 tcttgcaata ggtgtttcgc ttttgttaaa gacatttgag ctttaggatt tcgatacgat 1216741 tgattaagtg tacctaaatg cggaagatgt tcgaagtctt ctttagttgg aggcatgtga 1216801 aaatagtagt ctccgattga gataagcacg tccgattgct gttggctgaa ccttggattt 1216861 tttgaaaaat gaagccctat tttctttcct ttaccttctt tgacaagctt ttgcaaagcc 1216921 cgttttttca gcagatatag gtatttaggg ttgggggcgg tttttgcatg gcggttcaca 1216981 gtgtaaactg cttttgaaag attttctacg gttggctgca gatctttcgt atatgcatgg 1217041 tcgtccatta tttctctcct ttgctcttat caatttctat atgtttagat tatacttttt 1217101 taaagttgaa atgcaaatat tgaatgtaaa aatgcgcttt tttctaagaa aaaaagcgca 1217161 tttttaacct gcattataca gatcttgcct tctttttcgg ctgttcttga aatgcttcct 1217221 gaacattcac ttccacagcc tgagcactgt attttggcag tgcaataaaa taaaaaataa 1217281 aaacgagcag gataataaca cccatgccgt aataaagata atcaatgttt gaaacaaact 1217341 tagggaataa cagcgcgact aagccgagtg tcaaagattg tgcaaacatc ataaaagggt 1217401 cctgcatgcc gcttacacgt cccatcagtt ttggatgaac aatttttggc atccaccctc 1217461 cgattgcaat gttgatcggt ccgatacaca ttcccagtgc aaaagctgcc gcgtaataca 1217521 cccataaaat attggtgtag ccgaggacga agatcagcaa acctgcaatg aaaatcggta 1217581 tcgacattaa aaagtgcggc ttcacttttt tagagatgag cgtgccgatt acgcttcctg 1217641 ccagaagccc aaacccgagt gcgatcgtaa atacagacgt atgccactca taacggtcag 1217701 gcgccaatcc atatttcatt gtaaacatcg gcaatacggc gaatcctcca ttgacaaatc 1217761 caaaaatgaa gaagccaaaa ataagagatg ccagcaattt gttttttaaa atatagagga 1217821 tgccttctct aaagtcattt attgaatcct taacagaagt ctttctccag ctgaatgcac 1217881 cgtttggctg tcgggcttct tttggaatcc ggcagctgcg gatcagcagc ccggaaatga 1217941 taaagctgac aaaatcaaga ataatggcgc cttcaatacc gattgtgttg tacataaacg 1218001 cgcctatgcc gactccaaac accataaaaa tgctaaaaag catctgatta agccctgccg 1218061 ctttcgcata atgctccttc ggcagaatgg cttgtaccaa actgttttct gccggaaaga 1218121 aaaactttgt tacagcgctt ctgataaata agatacaaaa aacaagagga atattgccgg 1218181 taaataaagt gaaaaaaagc acgacagtca ggcctgctct gatccaatca caattttctg 1218241 ccaccttttt tctatcaaac cggtccgcga cgactcccac gatcagaaat acaaatatgg 1218301 tcggaagaga atacatcagc tccgccaagg tcgtatatga aggctggctg ctgaatcggt 1218361 ccagcaaaaa aaaagcaaag gccatgttgc ctactgtcgt gcccatttga gaagcgagtg 1218421 ctgcgaaaaa tagacgaaca aaattacgat ttttaaatat atccataaaa acgctcctta 1218481 ccctaaaggt cccactttat catattataa accgcctgtt tttgaaacaa ataagaaaac 1218541 attaccggtt aatcgtgact ctcgttccgt ttggcacaat tgaagcaagt tcgatcacgt 1218601 ctttgttatg catgcgaatg cagcctttag aaacagcctt accaatcgaa gcgggattat 1218661 tcgtcccatg tattccgtag tgctgctttg aaaggctcag ccaataagcg ccaaatgggc 1218721 cgccgggatt gcgctggcgg ttaataatgt aaaactcgcc agtaggcgtt tgcgttagta 1218781 ttttaccaac ggcgatggga taggttttca ttacccgatt atttagggac agcgtaaggg 1218841 tcttcgctcc gattgagact gcgatatgat acggaattgt ataagggtcc ggcagtccgg 1218901 ggatgactat ggactgtccc gcggtgagcc ctgcctgcag tgacggatta gcctggagta 1218961 atgcagccgt gctgattctg aaatcagccg cgatgctgtt cagtgtatca ccttgcttca 1219021 cctggtacgt aagcagtttc ctcatcctcc ttttttactt ataagtattg atgaggagcc 1219081 catcctgcta cattaatttg tgctttttaa ggtgaagaca gtgatttcag gcttggcaag 1219141 aaaccgcaaa ggcagcctgg tcatcccgag gcctcggttt acgtaaatat gagtgctgcc 1219201 cgtttgatac attccctctg tgtagacttt tccatatgga ggcgtaataa tcggtccgta 1219261 aaaaggcagc tgaatctggc cgccgtgtgt atggccggaa agctgaaggt tcacgggata 1219321 atctgttgtt ttcaaggctg catcaggttc atggacgaga agaatggaaa aaagtctgtc 1219381 gctcagcctt gaaagggtgc cttcataatc tgggtttccc agcattaagt catcaagcga 1219441 agcaatctcg attttgctgc catctgcgag tgacaatgtt tgatagccat tgcgatatac 1219501 cgtgaaacct ccggccgtca tcaggctttt gtaaacggca gttccatagc ctccgtgatc 1219561 atgattgccg taaatacaaa gcttgccgaa gggagcatta agctttctca ataatggaat 1219621 gactgcctgg tggtgctggt acgtatcagg attatcaata atatcacctg taaaaacaat 1219681 gagatcaggt ttagattcat taattgtaag aatgacagtt tttaaatctt cgagagtaaa 1219741 gtaatcactc aagtgtgcat cgctgaactg cacgatttta aaaccgtcaa atccgtgcgg 1219801 gatgagagag ctttttattg tgtgttcggt tgtctcgatc atatgcggct cgagatacct 1219861 ggcatagcca tatcccccgc cggccgttaa agccccggca gcaagagcgc cgaacattcc 1219921 ttttagaaat tgtcttctgg acatcttttt catttcaaac caacctttaa tagagttttt 1219981 ctattatatc atctgtatct gataaaaatc tcatatgagc atgtgctgac agaggcaggg 1220041 atataatgat agaatattat tgaatgaata atcattcaca attggaggga taaacatgga 1220101 aaaaaaggcg gtaattatta ccggcgggtc aagcggcatg ggaaaagcga tggcaaaaaa 1220161 acaggctgaa ttagggtggc acgttatggt gacagggagg aaccatgagg cacttgagga 1220221 aacaaaaaaa gaaattcaga cctttgaggg acaggtcgct tgttttcaaa tggatgtccg 1220281 ttccgattcc gccgcttcag acatgattaa agaagcggta aaagcctttg gccggcttga 1220341 cgcgctgatt aacaacgcgg ccggaaactt tatttgtccg gcagaaaagc tgacgcccaa 1220401 tggatggaaa gccgttattg agattgtttt aaacggcaca tttttttgca gccaagcagc 1220461 ggcaaggcat tggattgacc agaagcagca gggtgtcatt ttaaatatgg cagccacgta 1220521 cgcttgggga gcgggagcgg gggtcgttca ttccgctgca gccaaagcgg gggtattgtc 1220581 attgacaaga acgctggccg ttgaatgggg gagcaaatac ggcattcgta caaacgcgat 1220641 agcccccgga ccgattgaac gaacaggcgg tgcggagaag ctatttgaat cggaaaaagc 1220701 gatggcccgc acgatgaaca gtgtgccgct cggccgattg ggcacaccgg aggaaatcgc 1220761 cgctttggca gcgtttttgc tttctgatga agcatcctat ataaacgggg attgtatcac 1220821 aatggacggg gggcaatggc tgaatcctta tccgttttaa tctgaatatt tataagtgaa 1220881 tatttaagtt attaagaact tttatgttcg aatgtaatac ctccacaatt aaccttcttc 1220941 ctatccaatt tgataacaca tagagcttta tttgtttatg aggtgttgtg tcatacgtaa 1221001 gccacctaat atatgaaagg tatattttaa aaggggagac gaaatatgaa gaacttagat 1221061 ttcaaataaa acattcatat aattacttcg ttaactaaaa agagaaatta taagaatgaa 1221121 aggtttcaag gttacatcag attgggagga aggtaatata atggacgaga tggtattatt 1221181 aactcaggaa tggctcaatg aaacgtacaa aggaaaaagt ggctacaatt ccattgagga 1221241 aaatgggaaa actggctgga aaacaatgta tgcattaact agagcattac aactagaatt 1221301 gggaattaca cagacttccg acagttttgg tcctacaact ttaagaaagc ttaaagaatt 1221361 aggcccgatt tctacgtcaa ctaattcaaa aaaaaatatt gtgaaaatta ttcaaggtgc 1221421 tctttattgt aaaggttatg gtccaggtgg attaacgggt acatttggtc agggaacgaa 1221481 agaggcgata gcagaaatgc aattgcatat ggggctttct aaaacagacg gtgtagtaac 1221541 gcctaaggtg tttaaagctt tattaaacat ggactcttat atccttttaa atggggcgtc 1221601 agagaaagtt cgttcaatac agcaatggct aaataataaa tattacaata gagagaattt 1221661 ctactttatg ccctgtgatg gcctgtattc aagggatact caaaagtctc ttgtttatgc 1221721 aatacagtac gaggaagggt taagtgatag tatagctaat gggaattttg gaccaactac 1221781 tcaaagattg attcctgtat taagaattgg agaaacagat gaaaaaaaca gttttattca 1221841 tttatttcaa gctgctctaa tctttaatgg ctacaatgtt ccttttgatg gagtatactc 1221901 tgaatctgta agatcaaaag taaaggcttt tcagtctttt gcaaaattac aacagagtgg 1221961 tactgccgac tttcaaacat gggcttcact tctagtaagt actggagacc ccaatcgaaa 1222021 aggagttgct tgtgactcaa ttactcaaat tacatcggac agggcggagt cccttaagag 1222081 ggcaggttat aagattgtag ggcggtatct aacaaatgcg ccggggagta cactaaataa 1222141 aaaaatacaa ccaggtgaat tagaaactat cttaaaatca ggtttaaatg tttttccgat 1222201 ttatcaaacc tatgggggag caacaaatta ttttaataaa gaacaaggaa agaaagatgc 1222261 gtttgctgct tataaagcag caaaagaata cgggtttaaa aataacactg taatatactt 1222321 tgcagtagat tatgatgcat atggtaacga tttaaacaac aatattattc cacacttcga 1222381 aggtataaat gaaataatga acggtttttt aggttcaact tacaaaattg gtatttatgc 1222441 ccctaggaat gtatgtacta tagtttctaa aaaaggttta gcatttgcaa gttttgtaag 1222501 tggtatgtct actggcttta gcggaaactt aggatatcct ttgccttaca attgggcgtt 1222561 tgaccaaatt tcaacaatta ctgttggaaa tggttctgga atgattgaaa ttgataatga 1222621 tatttgttca ggtttggata atggagttaa taccataaat atagtgcctt cagagaataa 1222681 gaagtttttt gatcaaattg atgttttata tgaaactgct gaaaaatatg ctcaaatgca 1222741 aagcgactta aataatgggg taaaaaaaac acaattagct aatgagttgg ttgcccagta 1222801 tttaagaaag gatgactaca aagggtggaa gtgggtccct accgcaggcc agattgatcc 1222861 tatttatcgt gaatgggcag taaagcgcta ggggaagacc tagtaaatgg aattgttgat 1222921 cctatatcaa aaactgtcat aggaacgcag catcttatgg caacttataa tgccattatt 1222981 tatagtggtg gttactctca aacactacga gattttgctg gttggactgg agatctatta 1223041 acaacaatac aggacatgaa attacacgct caagaattta attcgcctta tgatgcggct 1223101 atgaaaataa taggtaatat gtatcaattt agcctagatg atttatttag tgatgtagat 1223161 gcaattaatc tagcgaataa aacatcagtt ggtgctaatg cacaacctct aaatatcgca 1223221 attagagatt attatagtaa taatgactgt atgaataggt tcactcaatt tgtaaataat 1223281 agatttgatg gttcgttaga caaaattttc tctgaagcag agtattattt aaatacaaac 1223341 cttgacccag ttgttgttcc aattaggtta gcctttaaac gtgcttttga tgttgaggat 1223401 tatagtgaag agattggaaa aataacagca caagcattta gagatgttat cgagaaaaaa 1223461 atgatatctg aataaactgc aaaacaagcg aacgttaaaa ctggtcgttc gcttgtttta 1223521 ttttctattt aaatttatga tataattttt aaagattaag gagtgattca ttgaagaaat 1223581 tgttaaaaaa gttagttgta ttatttttaa gcagtttagt tatcatcttt aatgtttggt 1223641 actttattat ttgtgctttt tccccagagt attatcaaaa tacaaatctt acttctaatg 1223701 aaataataag atttgaaaaa ctataccaca tagattttcc tgatgaaaca aaatttatta 1223761 aagctagaga gtatttggct gggcccggag gagatacgtc agctgtatta tatgtgtctc 1223821 tgccaaccaa gcgggtagaa aaagttttat ctgattacac gtatatgaaa ataaactata 1223881 ctgacaatgt cggttcaatg tatggagttg acgtttcaaa gagtgtcgcc ggtttaacaa 1223941 ctcttacatt tggcacttac gataaaaaag gaactttcta taatatgaaa catgatgatg 1224001 attggatgta taaaggcact gactggaatc tttacttttg gacagctgct agttataatg 1224061 ctgttatttt tgtatttgtt ttggttattg tgaaacaaat gaataaaatt cttaattaac 1224121 cagtatgtag attgataatc tcaaaaaaat tttcctcttc ttttaacata ctccatacga 1224181 cctacttttc catactatga tttttttgaa atttgtggtg tagttataat tgtgcgtata 1224241 atcagacaaa gatagagaag caggtgataa catgttggat ccacttgata ttttaacgaa 1224301 cattgatgat gtccttccat attaccaggc gatttttagt gccgaggagc agaaggttgt 1224361 cggatatgag gtgcttggac gaattttggc agattcagaa atccaaagtc tcgggccctt 1224421 ctttttagat gcggggatac ccgaagaata taaattagag gttgataaca gaattatccg 1224481 ccaggctctt gaccgctttt tagaggcgga ttctgatctg ctgattttta tgaatcagga 1224541 tgccaatctg ctgatgctgg atcatggtga aagctttctg gagcttctga aagaatatga 1224601 agcgaaggga atcgaactcc accgttttgt gcttgaaatt acagagcaca attttgaagg 1224661 ggatattgag cagctctacc atatgcttgc atactatcgt acatacggaa ttaaaatcgc 1224721 agttgacaac atcggaaaag aaagcagcaa cttggacaga atcgcgctgc tctcaccaga 1224781 tctgttaaaa atcgatttgc aggcgctgaa agtgtcacag ccgtcaccgt catatgagca 1224841 tgtgctgtac agcatatctt tattagcaag aaaaatcggt gcggcgctgc tgtatgaaga 1224901 cattgaggcg aacttccagc ttcagtacgc ctggagaaac ggaggccgct attttcaggg 1224961 ctattactta gtgtctccat ctgaaacgtt tctagagaga gatgtattga aacaaagact 1225021 taaaactgaa tttcaccaat ttatcacaca tgagaaaaag aaactggaga ccgtctatga 1225081 gcactctgaa cagttttaca aacgagtgca tcaggctgtg acctctttga gaaaaaacaa 1225141 tctgtcttct gatgatgact ttattaaaaa gctggcggaa gagctgacag attgcagctt 1225201 caggatttac atgtgtgatg aagaaggcga tcagctgacg ggaaatgtgt ttaagcaaga 1225261 tggagaatgg atttatcagc cggaatatgc ggaaaagaac tggagctggc gcccttattt 1225321 tctggagaac attatgagaa tgagaaatct cagaaaaggt tttttcagtg atctgtacag 1225381 tgatttggaa acaggtgaaa tgatcagaac gttttcatat ccgatggatg atcagatgta 1225441 tttatttata gacttgcctt attcttattt atatgagcag gacggactga tttaacggct 1225501 gaaaggccgt tttttttatg aaatgaaaaa aatatcaaaa aacgattgac attgatactg 1225561 agaatcatta tcatttaatt atagagagaa gctactctct gttccccaac ccctctatca 1225621 gatcaagatc cgaaaaaact tggcgctacc cccgccaagt tttttatttg tcaaagcata 1225681 ggacaatcca atgaaacaat aaacctaact agtggtaaac gtttaacacg gggagaaaca 1225741 ttgagtgccg aacacccctg acactgctgc acgggtgagg aggaaaattc gttctgaaat 1225801 gattatttca gttccgttgt ttacctctat ccagcatgac tcccattgat tatggccacg 1225861 cgggacttca ccataaaatt caaaagaagg ttttgacaaa gttgcaaaaa ggcattctta 1225921 atgctgccaa agattcgaaa aaaattataa ttatgtgcat gacattcaaa aaaagcctca 1225981 aactaaagaa aaatagtttt tttcactttt tttctttgct taaattcagc agtgaaaatg 1226041 ccatcctgtc cgactttatg gtatgatgct caatagaact tgtattataa taaatacttg 1226101 ttgatttgaa gttgcttttt gaaaggagtc tttttttaga atgtcacaat taatgggtat 1226161 catcacacgg ctgcaaagtc tgcaagaaac agcggaagcg gctaacgagc caatgcagcg 1226221 ttatttcgaa gtgaatggtg agaaaatatg cagtgttaaa tatttcgaaa aaaatcaaac 1226281 gtttgaactg acggttttcc aaaagggtga aaaacctaac acatatccgt ttgataatat 1226341 cgacatggtt tccatcgaaa tctttgaact tcttcagtaa gattcctgaa atagggggaa 1226401 caagcttccg cctttgcaaa agtaatcgaa ataaacggta aggaacatac ttgtttcatg 1226461 gttgtaaatc cttgaaaagg agtgtcgtga tggctgattc ttttctgttt tataatcttt 1226521 cagaagcaca gatgaccttt caagatgtga tggaacggct taaagccttt gttcaaaagg 1226581 acccccgttc ttcttatgtg ttatcgatcg gaaccgattc acaggtttac cgcgattaca 1226641 caaagtttat taccgcattg catttgcatc gtacaggcaa gggagcttgg ggctgcttga 1226701 aaaatcatac agtcgacaga cccatacata gccttcggga gaagatttcg ttagaaacgg 1226761 cgtacagcca agaaacggcc gctcatattc ttgatggaca cttaatggat attaccgatc 1226821 tgctcctgcc ctttaccggt gagggggcgg atcttacctt tgaagttcac ttggatattg 1226881 ggaaaaaagg gcttacaaaa gatctgatcc aagaaatgac tggacgtatt acctccatgg 1226941 ggattgaggc caaaataaag ccggattcat acactgcctt cagctatgca aatcgtttca 1227001 caaaataatt tggctgaaaa agccaaggta aatgtcgaat tatgcggttg acgtttgtta 1227061 tctgattact tattctagcg gtagagctga aagtaagttg tcttgctttc agaggtattc 1227121 agtataaaac agggggcctg attgcgaatg agtcttatcg gtgaacgatt tacagaagaa 1227181 gaacaaaaac ttctgctgaa tatcctgatc aaccatgagt atgccatcga gctattaagc 1227241 agtgagatca acgatataga gacagggacc aaaaacgttg acggaaccac ctacaaaaaa 1227301 cttgtaacgc tatacgaccg atttcgattt gaaaattaat gggacaccct ataattgata 1227361 ctccacaaag agtatctttt ttattgaaag gaaacttttc gacaaatact gataaagttt 1227421 atattattgc aatataggga atgtattgat gatgaaaatg aaaaggggtc gaaaacatga 1227481 taagcttaca atcagatcaa cttcttgagg caacagtcgg acaatttatg attgaggcgg 1227541 acaaagtagc gcacgtgcaa gtcggaaata accttgagca tgcattatta gtattgacaa 1227601 aaaccggata cacagccatc ccggttctgg atccttccta ccgtttacat ggcttaatcg 1227661 ggacaaatat gatcatgaac agtatttttg gacttgagcg aattgagttt gaaaagcttg 1227721 accaaatcac tgttgaggaa gtcatgctga ccgacattcc gcgccttcat atcaatgatc 1227781 cgattatgaa gggattcggc atggtcatta ataacggatt tgtctgtgtt gaaaatgacg 1227841 agcaggtatt tgaagggatt tttacgagaa gagtcgtttt aaaggaattg aataagcata 1227901 tacgctcatt gaataagtag gctgtacggt cctattttta ttatataggc agagtgaaaa 1227961 aagaaagcgc atacataatt taaacgagaa tagggcttga ataagaaact aagattttat 1228021 tagaatggga gataagaaaa acttattgat aacaaaaagg aggacgacat gcagcttcaa 1228081 gagcttcata tgctcgtagt tttagctgag gaattaaata tgagaaaggc ggcagaacgg 1228141 ctttttgtat ctcagccggc tttatctcag cgcttacaaa ccattgaaaa ggcgtgggga 1228201 acaaaaatct ttttaagatc tcaaaaagga ttaacggtaa cgcccgccgg tgagaaaatc 1228261 attcagtttg cgaatgatgt gacattagag caggaaagaa taagagaaaa tattgacgag 1228321 cttgaaggtg aaattcacgg cacattgaag cttgccgtcg cctccataat cggtcagcat 1228381 tggctcccta aagtcctgaa gacgtatgtg gaaaagtatc cgaatgcaaa gatctcgctc 1228441 ataaccgggt ggagcagcga aatgctgaaa agcttgtatg aggatcaggt tcatatcggc 1228501 attataagag gcaaccctga gtggaagggg cgcaaagatt acttaatgac agatcatctg 1228561 tatttagtgg atactgaaat ttcctgcatc gaagatattg cccatacaga acgtccgttt 1228621 atccagttta aaagtgacag cacttatttt caggaaattc agcactggtg gcatcaaaaa 1228681 tttaaaacgt cgccgaaaca gacgatattg gttgatcaga ttgaaacgtg caaacagatg 1228741 gcgctgcacg gaatcggtta tgccattttg ccgtctgtta cccttcaaaa tgaagataaa 1228801 gtgaataaaa tgcctctttt agacatgaaa gggcatccga tcggtcggga tacatggtta 1228861 ttaggttatg agcctgcctt tgaactgaaa caagttcaag cttttgtaca agtgataaag 1228921 gatatgctgg atcaggaaaa tccattttaa agacagcgag gtgctgtctt ttttttattt 1228981 atctgttgac aatgaaaatc attatcattt aaagtgatac atatgatatt gaaaatcatt 1229041 atcaactaat ggggtgataa catggctaaa gccttgatta catatgccag catgtcagga 1229101 aatacagaag acattgcctt cataataaaa gatacgcttc aggaatatga gttggatatc 1229161 gattgtgtcg agataaatga tatggatgcg tcttgtttaa cctcctatga ttatgtactg 1229221 attggcacct atacatgggg ggacggcgat ttgccctacg aagcggagga ttttttcgaa 1229281 gaggtcaaac agattcagct taatggttta aaaacagcct gcttcgggtc tggcgattat 1229341 tcttatccaa agttttgcga agcggtgaat ttgttcaatg tcatgctgca agaggcggga 1229401 gctgctgttt accaggaaac actaaaaatt gaattagcgc ctgaaacaga tgaagatgtg 1229461 gaaagctgcc gagcgtttgc gagaggtttt cttgcatggg cagattatat gaacaaggaa 1229521 aaaatccatg tttcataaag gggcaaccgc tgttacggca tcggcgtttt ctggatattt 1229581 tgtggcggta caaagagaag gcatttttca ttactctttg gagcagggct ggagaaagct 1229641 ttttcgtttg aaaagtaaga tacactgtat cagctacata gggccttact tatttggcgt 1229701 tggtgaaaag ggaacagtca ttcgttcggc tgatgaaggg aaaacctgga cgatgtcgag 1229761 ctttccgaca aatgcaacag tgtgggcgat taccggcaga aacaacgggt ttgtctgcgc 1229821 ccacggtaag cattgtattt atgtatcgga tgattttggt gtctcatggc gcgtagccaa 1229881 accttttgcc gaatttcata atccccctgt tatccggtcg ttatgccttc acgggggcaa 1229941 tctctttatc ggcacgcaaa tacacgaata ttttggcggc atttgggctt acgacattaa 1230001 gcgtgacact gtccaagttg tcaaaaaaga aaaaaaccgg atgacggcat ccatgctcgt 1230061 gttcaatgaa aattggctgg tggcggcgat gggttctgtg aaaggaaagc acggtgctgt 1230121 cactgtaagg aatcttttga atggtgaaga attcaccata caatccagta tgatcagaaa 1230181 tgaagaatca tttcttgatc tttcagagga tgatggcatt atatatgtca ctacaacaca 1230241 agatgaaaat ggtttttcga gaatttacca ggttgatctc gaagcccggt cgttaaaatg 1230301 gttcgatacc attaagggac atggatggag agtggccaat cagaaagaga atttcttttg 1230361 cgcaggcttg tatgaatgta aatttgtcca gccgtacgaa gtttcagcaa tgattcatta 1230421 gaggaggaac aaggaattgg cgaagatttt gctcgtttat gcaacaatgt caggcaacac 1230481 tgaagctatg gcagatttga ttgaaaaggg gcttcaggag gcgttagcag aagtagaccg 1230541 tttcgaagca atggatattg atgatgccca gctgtttacc gattatgacc atgtcataat 1230601 gggaacctac acgtggggag acggagatct gcctgatgaa tttttagatc ttgttgaaga 1230661 catggaggag attgattttt ccggcaaaac atgcgctgta ttcggttccg gtgatacagc 1230721 atatgaattt ttctgcggag cggttgatac gctagaggca aaaataaaag aacgcggtgg 1230781 agacattgtg ctgccttcgg taaaaatcga aaataatcca gaaggtgaag aagaggaaga 1230841 attaataaac ttcgggagac aattcgcaaa gaaaagcggg tgcgctgtct gatcactcac 1230901 tgggaactgc taaaacggct gttccttttt ttcttgtctt tgtatctttc ctttgataca 1230961 gtaatgaggt agaaaatcag gaggaggact atacatatga aaatgatgga cgcaaatgaa 1231021 attatttcat ttattcaaaa tagtacaaaa tctacacctg taaaggttta cgtgaaaggt 1231081 gagctggaag gaatcaattt cggtgaatct gcgaaagctt ttatcaatgg aaacactggt 1231141 gtcgttttcg gtgaatggag cgaaatccaa acagcaatcg aagaaaacca aagcaaaatc 1231201 gaagactatg tggttgaaaa tgaccgccgc aattctgcga tcccaatgct tgatcttaaa 1231261 aacatcaaag cgcgtatcga gccgggtgcg atcatccgcg accaagttga aatcggtgat 1231321 aacgcagtca tcatgatggg tgcttctatt aatatcggtt cagtcatcgg cgaaggcaca 1231381 atgattgata tgaacgttgt gcttggcgga cgagctactg ttggaaaaaa ctgccatatc 1231441 ggcgcgggtt ctgtacttgc gggcgttatt gagccgccat ccgctaaacc ggttgtgatt 1231501 gaagacgacg tcgtaatcgg cgcaaatgct gttgtgcttg aaggtgtaac agtaggtaaa 1231561 ggagctgttg ttgctgcggg agcgatcgtg gtaaacgacg ttgagccata cactgtcgtt 1231621 gcaggcacac cagctaaaaa aatcaaagac attgatgaaa aaacaaaagg caaaactgaa 1231681 atcaagcagg aattacgcca gctgtaagga aaagtttgat aaaaaaggcg tggataatat 1231741 atccacgcct tattcgtata ggcaggagga atagaaatga agatagagga gctcatcgca 1231801 attcgcagag atctgcatcg tataccggag cttggatttc aggagttcaa aacccagcag 1231861 tatttattaa atgtcttgga acaatatccg caagacagaa ttgaaattga gaaatggcga 1231921 acagggcttt ttgtaaaagt gaacgggacg gcgccggaaa aaatgctggc atacagagcg 1231981 gatatcgatg cgctttctat agaagagcaa actggtcttc cattcgcatc agagcatcac 1232041 ggcaacatgc acgcctgcgg tcacgatttg catatgacaa ttgcactcgg cattattgat 1232101 cattttgttc accacccagt caaacatgat ttgctttttc tgtttcagcc ggcagaggaa 1232161 gggcctggcg gtgcggaacc aatgcttgag agcgatgtat taaaaaaatg gcagcctgat 1232221 ttcatcactg cccttcatat tgctccagag cttccggtag gcaccattgc gacaaaaagc 1232281 ggccttctat ttgcgaatac atcagagcta gtcatcgatc tggaaggcaa agggggacat 1232341 gcggcatatc cgcatttggc tgaggatatg gttgtagcag caagtacact tgtcacccag 1232401 ctgcaaacga ttatctctag aaacacagat ccgctagaca gtgctgttat tacagttggt 1232461 accattaccg gaggctcggc acaaaatatc attgcagaaa cggcccacct ggaaggcacg 1232521 atccgcacgc tttctgaaga atcgatgaaa caagtaaagg aacggattga agatgtagtg 1232581 aaaggaatcg aaatcggatt ccgctgcaaa ggaaaagtga catatccgtc tgtatatcac 1232641 caagtttaca atacgagcgg attaacagaa gaatttatgt cttttgttgc tgaacatcaa 1232701 ctggcgacag taattgaagc aaaagaagca atgactggag aggattttgg ctatatgctg 1232761 aaaaaatatc ccggattcat gttctggctc ggcgctgatt ctgaacatgg gcttcatcat 1232821 gctaagctga atcccgatga aaatgcgata gaaacagcgg ttcatgtcat gacaggttat 1232881 ttttctgttt atgccaatta agtacaaatg aaagaataaa attccataaa atgagcactc 1232941 tagtaaacgg aggtgttcaa aaatggctaa aaaaattgga attgaacaat cgttatcaga 1233001 tgtagaagct gctttaaaag aaaaaggata tgacgttgta atgatgaaaa gccctgctga 1233061 tgctcaaggc tgtgactgct gtgtcgtaac aggtcttgat aataatgtgc aagggatagc 1233121 cgatacggta acacaagcac ctgtcattac agcttccggg atgacggctg aagaaatttg 1233181 tagcgaagtt gagagcagaa ttcagtaata aaaaaaccga agcaaaaagc ttcggttctt 1233241 ttatttattc tgtttcttta gggaaagcgc ggtcgaacgc gttctttatt tcttttctca 1233301 acactcgttc gactcgccac tgttccatat tttctgtttt ggcaatgacc ctgattacaa 1233361 tttcagaagt ccccagttct tgaatcccga tgacatttgg gccttctttt atttgtggaa 1233421 gagccgctgc cgtttcatca caaacctgct gtaaaatatg aatcatttca tcaatatttc 1233481 tttcagccgg cactttaatg tcaacaagag cctgcatggt accacgagaa tgattgctca 1233541 cgtttgtgat gtttctgttg gggatgtaat gcagtgttcc gtcaaagctg cggatttgag 1233601 ttgtccttaa gccaacctgc tcgacaattc cgtcaaaggt ggaaacggta atataatctc 1233661 cgacatccaa ttgtttctca agcaaaataa aaaaacctgt cacgatatca ctgacaagcc 1233721 cttgggcgcc aaatccgaca gccaggccga cgattcctgc ccccgctaaa agagcgcttg 1233781 gatcataatg aaacaaatct agaaccatga cgaaaaatat gaaaatcaat gtataagcaa 1233841 atatgttaag agtcaggctt cggagcgtat gtgcacgtcc gatagacaag ctattctgct 1233901 cctcgaattt tgcaaacaga tgtttaatga ttttcatgcc taatgatcga acgataaaat 1233961 agagcaatat cataatggcg agtttaatga gcagaacacc ggcatttgta atcagtcccg 1234021 cccaatcata ttgtttaata aagtccatgt tgagctcctt ttctaattga ttgctgcaca 1234081 ttgagactag ttaccctgta catgaccatg ttaaacgttt tattcaaaaa tgtcgaagcc 1234141 aaagacatac atgatttgtt aaaaattgac tcaggaaatc tgcttttata taatggcatt 1234201 gcaatataac taaaaatggt taatcaccct ttattttcat gcgattttga cctttaagcc 1234261 aaacaataaa ttggagggat acatatggca gaacgtatgg taggtaaaca agctcctcgt 1234321 tttgaaatgg aagcagtcct tgcaagcaaa gaattcggca aagtaagtct tgaggaaaac 1234381 atgaaaaacg acaaatggac agtgctgttc ttctatccaa tggacttcac ttttgtttgt 1234441 ccgacagaaa ttacagcaat gtctgaccgc tatgacgagt tcgaagatct tgatgcagaa 1234501 gtcatcgggg tttcaactga taccatccat actcatttag cttggatcaa tacagaccgc 1234561 aaagaaaacg gtcttggcca gctgaaatac ccgcttgctg ctgatacaaa ccatgaggta 1234621 tcccgggaat atggcgtttt aatcgaagaa gaaggtgtgg ctttgcgcgg attgtttatt 1234681 attaatcctg aaggggagct tcaatatcaa actgttttcc ataacaacat tgggcgtgat 1234741 gttgatgaaa cgcttcgtgt tctccaggcg ctgcaaactg gcggactctg tccggctaac 1234801 tggaaaccag gccaaaaaac actttaattc tttccaagaa cgaaaagcgg tctagcatat 1234861 tcgttaggcc tctcttttaa aataggaggg aaaaagcaat gaaattacgt cagcccatgc 1234921 cggaattgac gggagaaaaa gcttggttaa atggtgaagt gacgagagag caattgattg 1234981 gggaaaagcc gacgcttatt catttctggt ccatcagctg ccacttgtgc aaagaagcga 1235041 tgccgcaagt gaatgaattt cgtgataaat atcaagatca gctgaatgtt gtagctgtac 1235101 acatgccccg ttccgaagat gatcttgacc ctggtaaaat taaagaaaca gctgctgaac 1235161 acgatatcac tcagccgatt tttgttgaca gtgaccatgc tttaaccgat gcatttgaaa 1235221 atgaatatgt acctgcatat tatgtgtttg ataaaacagg acagctccgt cacttccaag 1235281 ccggcgggag cggtatgaaa atgcttgaaa aacgtgtgaa ccgcgttctg gctgaaacgg 1235341 aataggtatc tgactaaata gtatttccta aaaacctgac ctcatcaggt tttttatttg 1235401 tgcaaaaagc aatggaagaa gagtaagaag cttatttttc caaatttggg tataggaatt 1235461 gatgatttgt ttgattgata cgctaaaaaa cacagctaat ttttgatgtt tttcctcaat 1235521 tttagataaa tctcatatct cataactcga aaattgtaga tattacacta aatttcttta 1235581 aagaagtaag taaaatatat attttcaaca ttataccaaa taaactagaa agccccttaa 1235641 tcccttgaga ataaaggact cttttgaaaa ataaaacatt ttcagaaaat aaggaatttt 1235701 tcatagagta aatataatag taaaatgcta aaataatagt tgataaaatt acttttgtaa 1235761 tctaatatct taattaaaga tgttaatttt gatagggggt acattgagga atgtttaatg 1235821 aaagagaagc tttgcgcttg cggttagaac aattaaatga agctgaagtg aaagtcattc 1235881 gtgaatatca aattgaacgt gataaaatat acgcaaaatt aagagagctg gacagaaatg 1235941 gaagcccttc cgaaatcaaa aaggatttcc gttctgaaaa aaaacctgac tctctgccgg 1236001 ttctcgctga gcttgcggct caggaaatca gaagctatca gccgcaatca cagcagcagt 1236061 ctgttcagcc tcagcttcaa tctatttcct ctcttcctgc cggtatacca gacggaacaa 1236121 cacgaagaag aagaggaacg gcaagaccgg gatcaaaagc agctaagctg cgtgaagctg 1236181 ctattaaaac attaaaacgc cacaacgcgg cgattaagag ctcggagctt caaaaagaga 1236241 ttgaaaaaga aagcggtctt gaaatcccta atatgacaac gtttatgcaa agcttaatta 1236301 aaatgtaccc ggaagtgaaa aagccatatc gcgggcagta cattttagag ggtgaaatcg 1236361 aatctgcaga atcagcaaac gaataaatat aaagaaaaac tgcttggcat cgctcaagca 1236421 gtttttttat tgaggttttt tctgtgaagg tttgttttct ttttcaagat taagcttata 1236481 cacccacttt tgataaggct tttcttcagc ggctctgttt ttcagctctt cgattgtatg 1236541 gctcttggcc tggtctgatg attgggcgtg ggcaagctgt ttttgaagca catgtatctg 1236601 tttggtgaca tcttcaagga tagtctctac atgatttggc tgcgcgtagg ccgctggagc 1236661 ttcttcttcc gttttttctt tttgtttcgt gccgccatca atatcggcaa aatgagaagc 1236721 aatccaggca tcgctttcat caagttgccg tttatacgat ataatagttt cgtgaaataa 1236781 tttttctttc gttttttcta tgtctagcag tctttctttc gtttctatga ttcgatcttt 1236841 catatgatca acttctattt taatatgttt tagctgatat tctttttcta ccatttgctc 1236901 ttttagacgc ccgttttcgg cttttatcaa ttcggcttgc tgttttgcct gaagcagtgc 1236961 attttgttcc tgctcaattg aggcttgaag ttcgctgatc cgtttatgaa gatttttatt 1237021 ttcttcttcg attttgactt tcgcaatatg aagtttatgt ttttcttcga tttcggctct 1237081 gcgtttatag gtttcagcag atagaagctc ctgcaaaaca acgattttat caagcagttc 1237141 agctcttatt tggtgcaggg tttggctggt gtgggaggca tgtttttctt ttgttgacat 1237201 atgtgttaat tcggcagaca gctgctggag tttttctttc atatcggtat tttctttgag 1237261 cagtttgtta tttttctgat gaaagtagct tgcttcaagt tcagaaatca gcttatggca 1237321 ccttgaaagc tcggatttta aataaaggtt ctcctgagac acgtcgtgga aaaaaggacc 1237381 tgatcttttc attcgaacca tctccctcat gatgttaaca ctacaatatg caaatactga 1237441 acagctattc ctctttaata aacagacaag cagtagcgtt gagcctttgc ttttgctatg 1237501 cttttaacga aactagaggt gagatgatat gaagcatgta aacgtactgc tggcaggggg 1237561 agcctcacgt cgctttggag aaccgaaggc gtttgtcaaa tggaagggca ggatgcttta 1237621 cgaatgcgct aaagaggcac ttggagaaca aacggttatc atcagccgtc ccgaatttat 1237681 tgatagattt caagaaaacg gtgaaaatga agtgtatcaa gatgctgagc catttcaagg 1237741 catggggcca ttggctggta tatataccgc ttttaaaaag acagacggtg atctttatac 1237801 tgttctttcc tgtgacacac cgctgataca aagaaggacg atgctggagc tcaaacgtct 1237861 gatgattgcc ggtgcggacg cggtagtccc aatttcagac ggacaagtgc agccattgat 1237921 tgcgatttac cacaaacgta tcatgccagt tctatacgat cagctttctg agaagaggtt 1237981 gagaatatca gatttattag gcagaatttc ggtttgttac gtacaggctg aaaatatcgg 1238041 agcaaacccg gcagagttta tcaacattaa tacacgtgat gattttagct gtttggaaga 1238101 aaaatcgaac tccctcaagc gggactgacg gggcaataac atgataagat gacataaaag 1238161 ataaggagaa caggtttgat ggaggaacgt tattcacggc aaatcagatt taagcaaatt 1238221 ggggaagagg gccagaaaag actggcagac agccatgtgc tgattgtcgg agcgggagcg 1238281 ctcggcactg caggagctga agggctttcg agagcgggag tcggtacgat taccattatt 1238341 gaccgtgact atgtggagtg gagcaatctt caaaggcagc agctttatac agaaagcgat 1238401 gccaaactcc gcatgccgaa agccatggct gccaaagagc atctatcagc gattaacagc 1238461 gagatacata ttgaggcgta tgttaccgaa ggaacagccg aaacgcttga gccgctgatt 1238521 gaaaaagcag atgtcgtgat cgacgcgaca gataattttg aaacccgcat gctgataaac 1238581 gatcttgccc agaaaacaaa gacaccttgg gtctatggcg cctgtgtaag cagccaggga 1238641 atgttcatga ctgtcattcc cggagaaacc ccttgtctgt cttgtttgtt tgagcaaatt 1238701 cctgtcggcg gggcgacgtg tgatactgcc ggcattattc cgcctgctgt gcatatcgtt 1238761 tcagcatatc agcaggctga ggcattaaag ctgttaaccg gccaaaaaga agcaatacag 1238821 cgggggtttg tgacatttga tgtctggaac aattcgcata tgaagattaa cgttaatcat 1238881 gtacgccgtg aggaatgccc atcttgcgga gctaatgcgg tatatcctta tcttcaggat 1238941 tggaacacac caaaagctgc tgtactatgc ggccgtgata cagtgcaggt aaggtcagaa 1239001 tcattaaaaa gaatcccgaa acaggagctc attaagcggc tgaaaacaat cggcaaggtc 1239061 gaggctaatg cgtttttgct gcatattttt tacgaggatt tcagaattgt cattttcaat 1239121 gacggacggg cactggtgca tggaacaaat gatgtgaaag aagccaactc cgtgttggca 1239181 agagtgattg gactgtaaca acaggagggg tcagaatgct ggagaaaaga acaccgatac 1239241 cggtagacga ggcagttcgg cgtgtctgcc attttcaaaa acaaggtgaa acagaatggg 1239301 tggcgcttga agacagcctt catcggtttt tagccgaaga tataactgcg gatcaccacg 1239361 tacctgcgtt tgaccgttcg ccatacgatg gttttgctgt cagagcgtgc gatacggcag 1239421 aagcttcacg tgaaaaccca gttcggtttg aagttattga ccatattgga gcgggagcag 1239481 tatctgaaaa agaacttggc ccgtttcagg ccgtgcggat tatgactggc gcgcaaatcc 1239541 ctgaaggggc agatgcagtc gtcatgattg aactgactca agcctttgag gagaatggga 1239601 agtcatttat gtctttaaaa cgccgctttc agacggggga taatatttca aaaacaggtg 1239661 aggacgctca aaaagggagt gttttactga caaagggcac ccgggtgaca ccaggagtga 1239721 cggctctttt ggcaacattc ggatacgcat ctgtgcctgt cgtgagaaag cctgtagtcg 1239781 ggattatcgc aaccggtacc gaattgctga atgtcagtga tccgctggaa ccgggaaaaa 1239841 tccgcaacag caatgcgagt atggtatatg cgcaagcgat agaagcaggc gcaacaccgc 1239901 tttatttagg gaaaatctct gatgaactgg ataaaagctt tgctgcagtt aaagaagcga 1239961 tgaaaaaggt ggacttcctg atcacaactg gcggtgtgtc agtcggtgac tttgactttt 1240021 tgcctgcgat ctatgaaaaa ctcggagcgg acgtgctgtt taataaagtt gccatgcgcc 1240081 cgggcagcgt gacaacggtg gcgcatgcaa acgatatgct gctgtttggc ctttcaggta 1240141 atccgtcggc atgctatgtc ggttttgaac tgtttgtcaa accgataatc cagacatggc 1240201 tgctcaatga aacaccgcat tcaatttgtg cggaagctgt tttgaccaag gattttccga 1240261 agccgaaccc atttacccga tttgttcgtg cgctcgtgca ccatcaggaa gggaagctgt 1240321 tggcgacacc cgttggctta gataagtcga gctctgtcac atcacttgca gatgccaatg 1240381 catttattat cctgccgggc ggtacgcgag gctacgaatc tggcagaacg gttcaagtgc 1240441 tgctcatcag agaagagaat ggaagtgaat ggccttggtc cgtcctttcc cgatcgtcca 1240501 agttgtagga tttcaaaaca gcgggaaaac aacgtttatt gagcgcattc ttgaaaaagc 1240561 ctctgaacag ggagtccatt tgggctgcct gaagcaccat ggtcacggcg gtgaaccgca 1240621 aacgctcacg gaaggaaaag acacggaccg ttacaaggcg gcaggtgctg atgtaacagc 1240681 ggtagaaggt gctggtgtgt tacagctgac tgcccgccgc aattgggatt tggcacggct 1240741 gattgagtta taccaatttc tcgaaacaga ctgtcttctg attgaaggct ttaaaaaagc 1240801 cccttatcct aaagtggtta tcctaagtga aaaggaagat ctggaagcgc tgcaagcagt 1240861 aaatataatc gccatcatct atagaaaaaa agagcatatg acagagcatc agggattacc 1240921 cgtttttcat gcggatgatc cggttgccgt ggattttgtg ctttcacagc tgaaggggga 1240981 atctgcataa tggaacggtt tgagattacg aaaacaccca ttaatactga aaacatcatc 1241041 aaaaaagtgg agaaacggga agcgggagcc attacaacat ttattggtac ggttcgggaa 1241101 tggacaaacg gaaaaagaac ggttcggctt gaatatgagg catatgaacc gatggccgtg 1241161 caaatgcttg ctcaaatcgg cgctgaaatc gaagaaaaat gggaaggtgc ctcagctgcg 1241221 atcacgcacc gtataggtgt gctcgatatc ggtgaagcag cggtagtgat tgctgtatct 1241281 tctccccatc gaaaagccgc atatgaagcc aatgagtatg cgattgaacg cattaaacag 1241341 attgtgccga tttggaaaaa agaaatttgg gaagacggtg agcaatggat cggcgaccag 1241401 ctagaaacga cagcttatcc gaacggaaaa ccagacctaa gcgagggaga gcagcatgat 1241461 taaaattctt ttatttgcag ggcttgctga acaggccggt acacaagcaa tagaaataga 1241521 tatggaacaa gcaaccacag atgaaataaa agcgagtcta aaagaacaat acggtcttga 1241581 atctattgat acggctatga ttgccgttaa cgaaagctat gtaaaagaaa atacctctgt 1241641 atcttcgggt gacacggtag ccatcatacc gccggtcagc gggggatgaa aaccggacgg 1241701 catttcagcc gtccggtttt tctgtatttc attggcatat ccccaagtat cctcagcata 1241761 caatgatttt ctgtaagcgt ttattctaca tatgttactc cctataaagt aagagactca 1241821 ctccataatt agactgaaat tttgaaaaat aatagaaatt tatttcgggt atcgatatag 1241881 tgaagatgat aaatgttgga aaggtgctgg atatggagac atttaaaaga ttaaaaatgt 1241941 attattggcc gtacagaaaa gtgtttatgt ggtcgcttct agccatgctt ttgatgactg 1242001 caattactgt cgtttatccg attatcctgc aaattacgat tgatgagatc gtactgggac 1242061 ggcagtatca gcttgcggcg tgggtcagct taggatttat tgcggtgatg gttttgaaag 1242121 gaatggctac cttttttcat cagtatttag gtgatatgtt cgggatcaaa tccgtttatc 1242181 ggctgagaaa tggtctgtat gaaaaactgc agcggctttc tttttcttac tatgataacg 1242241 cgaaaacagg agatttgatg tccaggctga ctgctgatgt tgaagggctt cgttttttct 1242301 tatcatacgg tctcgctgag ctcattcgct tcggcctgct ggtagccatc agcctgtcgg 1242361 ttatgtttta ctattctgtt cctctcacgc ttgtgacaat agctgttctg ccatttctcg 1242421 cggttgcggt ataccggttt gacaaaagag tccatcccgc cttcagaggc atccgcaaat 1242481 cgtttgcgaa actcaataca aaagttcagg aaaatatcag cggcattaat acggttaaat 1242541 ctctttccag ggaagatttt cagatcagca ctttcaataa agccaatgca gaatacaggg 1242601 cgcagtattt acaaacatca tccatttggt ctgcgtattt ccctttaatg gagttcattg 1242661 gtaacacttg tattgtagct cttctctcat acggcggtta cttggttatg caaaatcagc 1242721 tcaatcccgg cgagcttgtt gctttcttca gccttgtcaa ttatatgatg tggcccatta 1242781 tgaacttagg ttttgtcatc aatatgttct ctcaagcaaa agcgtcaggg gaacgcctgc 1242841 tcgacattct ggaaaaagaa gaagacatta cagatcatcc tcatgctttg cataaacaaa 1242901 aattaaccgg agatgtccat ttcaaaaatg tttctcttgc atacggaaaa gaacaaacaa 1242961 acgcgctgtg caatgtaagc tttgaggcaa acagcgggaa ggtaatcgga ctgttgggcc 1243021 cgacaggttc aggcaaaagc tcagtgacac agcttctcac cagattttac agtcctgttg 1243081 gcggaatgat taccattgat cacaaaccca tcacagatta ttcgttaaaa acccttcgct 1243141 ccaatatcgg ggtcgtactt caagaatcct tcctgttttc atctacgatt agatcaaata 1243201 tttcgtatgg gcggccggat gcctcaatgg aagacgtcat cgaagcggca aaaagggcgc 1243261 aggctcataa ctttattatg gagcttcctg atgggtatga caccatgctg ggagagaggg 1243321 gaatggggct ttccggcggg cagaaacagc gtattgccat tgcgagagcc atctgcttga 1243381 acccgagcat tttaatattg gatgatgcca caagcgcagt agatatgcaa acggagcaca 1243441 gcatacagct tgccttaaaa gaagtcatga aaaaccgcac aacctttatc gtcgctcacc 1243501 gcatttcttc actgaaacac gctgatgaaa ttctcgtttt taataaagga cgcattcgtg 1243561 aaaggggaac acatcatgag cttcttgaaa aaggcggcta ctataaaaag atttacgatt 1243621 tgcaataccg tgatgtcaaa atgattaatg agccgcatga ggtcggatag ggaggggcca 1243681 aatgaaacaa gcgaaaaaac agggggtttt agagcgtttc tattactctt cagatgaaat 1243741 cattgaaaag ccgtttaact gggctcaaat gtggcggctg ctgagctatg tcaaaccata 1243801 tcgaaaaaca attttgccgc tttcttttct cactgtattg attggcactg ctgtgaagct 1243861 tgtgatcccc attttgatcg gcgtttatgt tcttgatcaa gcgattacag ggagaaactc 1243921 ggagctgctg attcagctca tttttattat tagcggttta tatgtcctca attacgccgc 1243981 caatgtgtta agaatcaggt ggatgaatca gcttggccag catgtcattt acgatttgcg 1244041 acagcattta tttacccatg tgcagcgctt atcccatcga ttttttgatc agcggtcggc 1244101 gggatcgatc ttagtcagga tcatgaatga tattaactct cttcaggagc tctttacaag 1244161 cggagtcatc aatttgttga ccgacttgct gcttctggcc ggcgtgatta ttattttgtt 1244221 tacgctgagc cctgagctga ctatagccat catggtgaca ttgccgatta tgttttttat 1244281 ttcaacaagt ctcagaaaaa aaatacgccg atcctggcaa acggtacggc tgaagcaatc 1244341 gaagctcaac tctcatctaa acgaaagcat tcagggcatc cgggtcacgc aggcatttac 1244401 gcaggaagaa gaaaacatgg cgtattttga cggtgtcaat caggagaact acgaatcatg 1244461 gcgggaagca actagaaaaa atgccatgtt ccgtccgctt gtagaaatga cgaatgcgat 1244521 tgggacggct gtcttgattt ggtatggagc cacactcatc atgaatgaaa ccattacgat 1244581 tggcgtcttc gtttcttttg ctttctatct gggaatgttt tgggaaccta tttcgagact 1244641 gggtcaggtc tataatcagc tgttaatggg gatggcatca tcagaacgga tttttgagtt 1244701 tctggacgaa cagccaaatg tcaaggagaa gccgaatgcc attcataatg aaaagataaa 1244761 tggggagatc agttttgaag aggttgaatt ttcgtatgat gaaaaacgaa aagcccttca 1244821 cgccgtttct ttctctattc ctgcgggatc gacgcttgcg cttgtcgggc atacagggag 1244881 cgggaagacg acgattgcca atttaatcag ccgtttttat gatgcggccg gaggcaccat 1244941 taaaatagac ggtataccga ttaaggatct ttcccttgcc agtctgcgct ctcaaatcag 1245001 cattgtcctg caagatacat ttattttctc cgggaccatc atggaaaata ttcgttttgg 1245061 aaggccaaat gcttcggatg aagaggtgat gaaagcgtcc caagcggtcg gagcggatga 1245121 gtttatttcc gatttagcgg aaggatacgc aacagaggta gaggaaaggg gcagcgtact 1245181 gtctgccggt cagcgccagc tcatttcatt tgcaagagca ttgctcgccg atccggctat 1245241 tatcatcctt gacgaagcaa cggcaagcat tgatacagag acagaagtaa aaattcagca 1245301 agcgttaaaa acgcttctga aagggcgtac agcagtgatg atcgctcaca gattgtctac 1245361 gatccgcgac gccgaccgca tcattgttct tgatcacggc aggaaaatag aagaagggaa 1245421 ccatgatcag ctgctcgcta aaggaggcat ttatgccggg cttgtgaaag cgcaatacag 1245481 cacagcgata gaataatatg aaaagccttc aatattgaag gtttttggaa atttattaga 1245541 aaaacatgaa actttttgat atccttcccg tactatttgt tagatattct caaggaggtt 1245601 ttgaaatgga aacgaatgta gaaaaaaaca gcggaacggc gactgaaaag ccttcacttt 1245661 tcggagtaat cacaagtccg tccgttcaat ttgaaagaat aagagaaagg ccggctgtat 1245721 ggggaccgct tttgattgtt gcagcaatta tcatcgtcgg tgccgtgctg caatcactcg 1245781 gtacggatta tagtgagctt ttgaaaagcc aggatacgca agggctatct gctgaacaaa 1245841 tggaaactgt cgcaacaata accaaatttg gcggaatggc aggcgctatt atcggcggta 1245901 tcgcagcatt atttattgcc cctcttattt attggctctg tgtaaaagta tcaggcggtg 1245961 ttacgacata taaaaaaatg ctttctctca gtctgtttgt ctctttgatt agcagtctcg 1246021 gattattggt taatggaatc gttgctttta cgactgacgt gaatcctctt tacagcacga 1246081 cgtcactcgc agggattatc ccatctgacg gggctctcgc cagtgtgtta aatacctttg 1246141 aaattttcag catctggagc tttgtattat tagcaatcgg acttcacaaa acgggaggca 1246201 tctcaaaaaa agccgggtgg atttcagcaa tcattctatt cggaatttta gttgtatttt 1246261 cgcttttttc aggtttaatc aattctgtgg cgggtgcata agctcatgaa aaaagtctgg 1246321 atcggaattg gaatcgcagt tatagtcgct ctttttgttg gaatcaatat ataccggtct 1246381 gccgctccga caagcggcag cgccggcaag gaggtacaga cggggagcgt tgaagaaaat 1246441 gaaatctcat caacggttat ggttcctggc acgctaaaat tttcaaatga acagtatgtc 1246501 ttttatgaag cggataaagg gacattagaa gacattaaag taaaggaagg cgataaagtt 1246561 aaaaagggca cggctttagt cacctataca aatgagcagc tgagcctgga aaaagaacag 1246621 aaccagttaa cgtctgaatc caaccggctt caaattgacc aaattcaaga aaagttaaaa 1246681 gccttggaca gcaaagaaag agaactggaa aaacaggtag gaaagaaaga agcagaaaaa 1246741 caaatcgaat ctgaacggac agagcttcaa atgcagaaaa aaacagcgga gatcgaatta 1246801 aaacaaaccg agcttcagcg gcagtcactt gccaaccggg tgtcagattt agaagtgaaa 1246861 agcgaaattg aaggcaccgt tatttctgtc aaccaagaag cggcatccaa aaagtcagat 1246921 attcaagagc ctgtcataca tatcggcaac ccaaaagacc ttgtcgtctc agggaaattg 1246981 tctgaatacg atacattgaa agtcaaaaaa ggccagaagg tcacactcac ttcagatgta 1247041 atacagggta aaacatggaa aggcacggtt tccgcagtcg ggcttgttcc ggatcagcag 1247101 gagagcgctg cggcacaagg aacagaacag gcggtccaat acccgcttca agtgaaaata 1247161 aaaggaaatc ttccagaagg aaagccaggc tttaaattta tcatgaatat tgaaacagat 1247221 aaacggaaag caaatacgct tccttcaaag gcagtcaaaa aagaagatga ccaatattat 1247281 gtgtatacag taaaagacgg aaaagcaaag cgagttgatg tcaaaatcgg cgaagtgaca 1247341 gatgacctga cagaaattaa agaggggctt acccaagatg atcaagtcat tttgaatcca 1247401 tctgatcagg tgactgacgg aatggaagtg aaatcctaaa tgattcagct ttctaatgtg 1247461 cgaaaaagct accagatcgg aaaggaaacg tttgatgttc tccattctat tgatttggac 1247521 attcatcaag gtgaatatgt ctcgattatg gggccgtcag gatcaggaaa atcgacgatc 1247581 atgaatatta tcggctgtct tgatcggccg acttccggta catatcaatt ggacggcgaa 1247641 gacatttctt catataaaga taaagaactg gcggcagtcc gtaaccggtc catcggtttt 1247701 gtatttcagc aatttcagct tcttccgcgg ctgaacgcaa aaaaaaatgt cgagctgccg 1247761 atgatttatt ccgggatagg caaaaaggaa cgtcaagagc gggctgagag agcattggaa 1247821 aaggtcgggt tagccgatcg aatgctccac atgcccaacg agctgtcggg cgggcagaag 1247881 cagcgggtgg cgattgcgag ggcgatcgtg aatgagccga aattgatttt agctgatgaa 1247941 ccgaccggcg cgctggatac gaaaacaagc gaggcgatta tggatcagtt tacagcatta 1248001 aatgccgagg gaacgacaat cgttctggtt actcacgagc ctgaagtagc agattgcacg 1248061 aatcggatcg tcatggtgcg tgacggaaac attgttcctg ccagctccgg acaaaggagt 1248121 gtgggagaat gagcctgttg gaaaacatca gaatggctct aagctctgtc cttgcccata 1248181 aaatgcgttc gatcttaacg atgctcggca ttatcattgg tgtaggctct gtcattgttg 1248241 tcgttgcggt aggacagggc ggcgagcaaa tgctgaagca gtcgatcagc ggcccgggaa 1248301 atactgtgga gctgtactat atgcctagcg acgaggagct tgcaagcaac ccgaatgccg 1248361 cagctgaatc tacgtttaca gaaaacgata ttaaaggttt aaaaggaata gaaggcatta 1248421 aacaagtcgt tgcttcgact tctgaaagta tgaaagcgcg ttatcacgaa gaagaaaccg 1248481 atgctacggt taacggaata aatgatggat acatgaatgt caattctttg aaaatcgaaa 1248541 gcggcagaac ctttaccgac aatgactttc tcgcggggaa tagagtcgga atcatctctc 1248601 aaaaaatggc taaagagctg tttgataaaa cctcccctct aggtgaagtt gtctggatta 1248661 acggacagcc cgttgaaatt atcggcgtgc tgaaaaaagt aacaggcttg ctttctttcg 1248721 atttaagtga aatgtatgtg ccatttaata tgatgaaatc ctcttttggc acaagtgatt 1248781 tcagtaacgt atcattgcag gtcgaatcag cagacgacat aaaatcggct ggaaaagaag 1248841 cggcacagct ggtaaatgac aatcatggca cagaggattc gtatcaagtg atgaacatgg 1248901 aagagattgc ggccggaatt ggcaaagtaa ctgcaattat gacgacgatt atcggctcaa 1248961 ttgcaggtat ttcccttttg gtcggcggaa tcggtgtcat gaatattatg ctcgtatcag 1249021 tcacagaacg gacgcgggaa atcggaatca gaaaatcact tggtgcgacg aggggacaga 1249081 ttctgactca gtttttaatt gaatcagtcg tattgacgct gattggcggt ctggtcggga 1249141 ttggtattgg atacggaggg gccgcgcttg tttcagccat tgcgggctgg ccgtcactca 1249201 tatcctggca ggttgtatgc gggggcgtgc tgttcagtat gctcattggt gttattttcg 1249261 gcatgcttcc tgcaaataaa gccgcaaagc ttgatcccat tgaagcgctg cgttatgagt 1249321 agcctcatgc aacatgcatg aggttttttt atgtttagtg atttctacta tgaatataaa 1249381 agactttttt cattaaaata agaagaaaat gtcgtacaat tgtccttatt tttgtcgaat 1249441 ttacagttta caaaccctat agacatacgt taatatggag aaacgtgaaa gattttgata 1249501 gttattgaat gaatttgaat gattttagtt gcctaaaccg aaaatagcgt ttacaatgaa 1249561 attgtattca aaatgaatac gttttcatta ggaggtgaag catgctaact cctgaacggc 1249621 atcaattgat tattgatcaa atagaaaagc atgatgtggt aaagattcaa gagcttataa 1249681 atctgactaa tgcttctgaa tcaacaatca gaagagattt atcgaccctt gaagaacgcg 1249741 gttttttaaa gcgcgttcat ggtggagcgg ccaagctttc cgatatcaga cttgaacccg 1249801 atatgcttga aaaatcatcc aaaaaccttc acgataaact gaagattgct gaaaaagctg 1249861 cttctctttt agaagaaggg gattgcattt accttgatgc aggcacgacg acattgcaca 1249921 tgattgattt tatggataaa accaaagata ttgtcgttgt cacaaacggg gtaatgcata 1249981 tcgatgcatt aataaggaaa gaaatttctt tttatctgct tggaggatac gtaaagcaca 1250041 gaacgggcgc gattattgga ggcgcttcat tggttgccat ggaccagtac agatttgaca 1250101 agagttttct ggggacaaac ggtgtccata cagaggctgg atttacaacg ccggaccctg 1250161 atgaggccct tttaaaacag aaagcgatca aacaggcaaa acacgcttac gtcttagcag 1250221 acccttcgaa gttcggagaa atttcatttt cggcattcgc cggaataggc gacgcaacaa 1250281 tcattacgac tgacgctgaa gagcttacat tcgataatta ccaagaaaaa actgtcgtaa 1250341 aggtagtgaa accatgattt acactgtaac acttaatcca tctgtcgatt atatagttca 1250401 cgttgaagat tttactgtag gaggcctgaa ccgttcttcg tatgatacca agtatccagg 1250461 gggcaaaggc atcaacgtat cgagactgct gaaaagacac catgtggcgt ctaaagcgct 1250521 cggattcgtc ggcggattta ccggagaata tatcaaaaca tttttacggg aagaaaacct 1250581 ggaaacagct ttttctgaag taaaagggga tacccgtatc aatgtaaagc tgaaaacggg 1250641 tgatgaaact gaaattaacg ggcagggacc gacaatttcg gatgaagatt tcaaagcctt 1250701 tttagaacag ttccaatctt tgcaagaggg agatatcgtt gttcttgcag gaagcattcc 1250761 atcttcactc cctcacgata cttatgaaaa aatcgcagag gcctgcaaac agcagaacgc 1250821 acgagttgtt ctggatatct caggcgaggc tcttttgaaa gcaacagaaa tgaaaccatt 1250881 tttgatgaag ccaaatcatc atgagcttgg agaaatgttc ggcacggcca ttacatctgt 1250941 tgaggaagcc gttccttatg ggaaaaagct tgtagaacaa ggcgctgaac atgtaatcgt 1251001 atcaatggcc ggagacggag cgcttctgtt tacgaacgaa gctgtttatt ttgctaacgt 1251061 gccaaagggg aaattggtaa actcagtcgg agcaggggat tccgttgttg caggtttcct 1251121 tgccggaatt tccaaacagc tgccgcttga agaagcattc cgcttaggag ttacttcagg 1251181 cagtgctacc gcgttctctg aagaacttgg aacagaagaa tttgtccagc agcttcttcc 1251241 tgaagttaag gtcacacgtc tatagaggag gaaacacaag tgaaaataac tgagctttta 1251301 acgaagcata cgataaagct taatattgag agcaaagaaa aagaaaatgt tattgacgaa 1251361 atggtcactg ttcttgataa ggctggaaag ttaaatgacc gacaagccta taaagaagcc 1251421 attttaaatc gcgaaagcca aagctccacg ggtatcggtg aaggaatcgc tatcccccat 1251481 gcgaaaacgg caagcgttat caacccggcg atcgcgttcg gacgttcaaa agacggcgtc 1251541 gattatgaat cattagacgg ccagccggct cacttagtgt tcatgatcgc ggcgactgaa 1251601 ggcgcaaaca acactcacct tgaagcattg tcaagacttt caacgctgtt aatgcgtgaa 1251661 gaaatccgta agcagctcct tgaagctgag tctgaagatg ccatcatcga cattattaat 1251721 cagcacgata aagatgatga cgaagaggaa gaggaagaag aagcggcacc agcacctgcc 1251781 ggaaaaggga aaattttagc ggttactgca tgcccgacag gtattgccca tacattcatg 1251841 gctgcggatg cccttaaaga aaaagcgaaa gagcttggtg tggaaattaa ggtcgaaaca 1251901 aatgggtcaa gcggcattaa gcacaagctc actgcccaag aaatcgaaga tgcacctgca 1251961 atcattgtcg cagcggacaa gcaggttgaa atggaacgtt ttaaaggcaa gcgcgtactt 1252021 caagttcctg taacggcggg tatcagacgt ccgcaagagc ttatcgaaaa agcgatgaat 1252081 caagatgcgc cgatttatca aggcagcggc ggcggttcag cagcttcaaa tgatgatgaa 1252141 gaagcgaaag gcaagtctgg aagcggtatc ggaaacacgt tttataagca cctgatgagc 1252201 ggtgtcagca acatgcttcc gttcgtagtc ggcggcggta ttctcgttgc gatttcattc 1252261 ttctggggaa ttcactctgc tgatccgaat gatcctagct acaacacgtt tgcagcagca 1252321 ttaaacttta tcggcggcga caatgcatta aaactcattg ttgcagttct ggccggtttc 1252381 attgcgatga gtattgcaga tcgtcctggt tttgcgcctg gtatggtcgg cggatttatg 1252441 gcaactcaag cgaatgctgg attcttaggc ggcttaattg ccggattcct tgccggttat 1252501 gtcgtgattt tactgaaaaa agtatttacg tttatccctc agtcacttga tggattaaaa 1252561 cctgttttga tttacccgct gttcggtatt tttatcactg gcgtattaat gcaatttgtc 1252621 gtcaatacac ctgtagcggc atttatgaat ttcttaacaa actggcttga aagccttggt 1252681 actggaaacc ttgtgttaat gggtattatc ttgggcggca tgatggcgat cgatatgggc 1252741 ggtccgctta ataaagcagc ctttacgttc ggtatcgcca tgatcgatgc aggcaactat 1252801 gcgcctcatg cagcaatcat ggccggcggt atggttcctc cgcttggtat cgcacttgca 1252861 acaaccattt tcagaaacaa attcactcag cgtgaccgtg aagctggtat tacatgctat 1252921 ttcatgggag ctgctttcgt aacagaggga gcgatcccat ttgctgcggc tgatccgctt 1252981 cgcgtcatac cagctgctgt agtcggtgca gctgttgccg gcggattaac tgaattcttc 1253041 cgagtaacgc ttccggcgcc tcatggagga gtattcgtag ctttcattac aaaccatccg 1253101 atgctttacc ttttaagtat cgtgatcggt gctgtcgtga tggcaattat cctcggtatc 1253161 gtcaaaaaac ctgttacaga aaaataagaa aaaaagcgtc cttggttcga aaggacgctt 1253221 tttcttatcc ggccggcagg gagcgcggtt aagttatgta ttttattctt ttttatgata 1253281 aagtaaaaga agagaaacaa ctgacatagc aattgtctag gaggaaacac tttgaccgag 1253341 gaaaaaaata cgaatactga gaaaacggcg aagaaaaaaa ccaatacgta cctggaatgg 1253401 ggtaaagcga ttgtcatcgc tgttctgctg gctctcctga tccgtcactt tttgtttgaa 1253461 ccgtatttag ttgaaggttc atctatgtat cccacattac atgacggaga aaggctgttt 1253521 gtgaataaaa cagtcaacta tatcggcgag ctgaagcgcg gagatatcgt tattatcaac 1253581 ggtgaaactt ctaaaatcca ttatgtaaaa agattgatcg gaaagcctgg agaaaccgtt 1253641 caaatgaagg atgacacgct ttatataaac ggtaaaaaag tagccgagcc ttacttgtct 1253701 aaaaacaaga aggaagcaga aaaacttggt gtcagtctga caggagactt tggaccggtt 1253761 aaggttccga aaggcaaata ctttgtcatg ggagataacc ggctgaattc tatggacagc 1253821 cgaaacgggc tgggactgat cgcggaagat cgaattgtcg gcacatcgaa gtttgtcttt 1253881 ttcccgttta acgaaatgcg tcaaacaaaa taaaaacgcc ttgctggcct aggacagcag 1253941 gcgtttttat tttgaaaaag aagcgaccaa tgcaatgcat aaaaccgtga tgaacactga 1254001 accgataata gccagcacac tgaagaaaag gtgaacctgt ttgttctctt ttccgcgctt 1254061 ttctaatagc cgtttagaaa aaatgtgcga aaatatgtaa ataagggcta tgcctatata 1254121 taagccgata tctttggcgg taaagcctgt tacggcaagg taaaagcccg taaaaaagat 1254181 cagtaagcaa tattcagtaa gtgttaaaag cctcaacgtg ttcctccatg agagtgtgta 1254241 attttccagg cggatgcatt ctctctcttt aattgtaaca cagctggctg gtttgggtgt 1254301 ataagtgttt tctctctgtt ttatcaggga atcatttctc ttgccctgca ttcatggtat 1254361 acttttattg atgatagaca tgatggagga taataaatga ttgctgtaaa taatgtaagc 1254421 ttgcggtttg cggatcgcaa gttatttgaa gatgttaata ttaaatttac cccaggcaac 1254481 tgctatgggt taattggtgc aaacggtgcc ggtaaatcaa cgtttctaaa ggtgctgtca 1254541 ggcgaaatcg agcctcagac aggcgacgtg catatgagtc ctggcgagcg tcttgccgtc 1254601 ttgaagcaga accattttga gtacgaagag tatgaagtgc tgaaagtggt cattatgggc 1254661 cacaaacgcc tgtatgaagt catgcaggag aaagacgcta tttacatgaa gcctgatttc 1254721 tcagatgagg atgggattcg tgctgctgag ctagaaggtg aattcgcgga actgaacggt 1254781 tgggaagcgg aaagtgaagc tgcgatcctg ttaaaaggcc ttggtatctc agaagatctg 1254841 cacacaaaaa agatggcaga cctcggcggt tcggagaagg taaaagttct cttggcacag 1254901 gcattattcg gcaagccgga tgttctgctg ctcgatgagc cgacgaacca cctggacctt 1254961 caggcaattc agtggcttga agagtttctg attaactttg aaaacacagt tattgtcgta 1255021 tcccatgacc gtcacttttt aaataaagta tgtacgcaca ttgccgacct tgattttaac 1255081 aaaattcaaa tctatgtcgg aaactatgat ttctggtacg agtcaagcca gctggcgtta 1255141 aagctttctc aagaagcgaa caagaaaaaa gaagagcaga ttaaacagct tcaagagttt 1255201 gtcgctagat tcagcgccaa tgcgtctaaa tctaagcagg ctacatcaag aaagaaactt 1255261 ctcgaaaaaa tcacgctgga tgatattaaa ccgtcttccc gccgctatcc ttatgttaac 1255321 ttcacgccgg aacgggaaat cggaaatgat gttcttcgcg tggaaggctt aacaaaaaca 1255381 atcgatggcg taaaggtgct tgacaatgtc agctttatta tgaatcgaga agataaaatt 1255441 gctttcactg gccgaaatga acttgctgtt actacgctgt ttaaaatcat ttccggggaa 1255501 atggaagctg acagcggaac gtttaaatgg ggtgttacca catctcaagc gtattttcca 1255561 aaagacaaca gcgaatattt cgaaggcagt gatctgaacc ttgtagactg gcttcgccaa 1255621 tattctccgc acgaccaaag tgagagcttt ttacgcggtt tcttaggacg catgctgttc 1255681 tctggagaag aagtccacaa aaaagcaaat gtactttccg ggggagaaaa ggtccgctgt 1255741 atgctgtcga aagcgatgct ttctggcgcc aatattttaa ttttggatga gccgaccaac 1255801 catttagacc tagagtccat tacagcgctc aataacggct taatcagctt taaaggcgct 1255861 atgctgttta cttcccatga ccatcagttt gtgcagacca ttgccaacag aattatagaa 1255921 attacaccta acggcatcgt cgataagcaa atgagctatg acgagttcct tgaaaatgct 1255981 gatgtgcaga aaaaattgac tgaactatac gccgaataaa aaagcagaga tttctctgct 1256041 ttttttgata cctaaatgtg aaaggagatc acaacatgaa atttttggtt gtcggagcag 1256101 gtggagtagg cgggtatatt ggcggacggc tttcggagaa aggaaatgat gtgacatttc 1256161 tcgtgcgcca aaaacgagct gagcagctta aaaaaaccgg gcttgtcatc catagtgaaa 1256221 aagggaatgt atcatttcag cccgaactaa tcagtgccgg agaaacaggg caatttgatg 1256281 tcgttatcat tgcttctaaa gcatactcgc ttggtcaagt gatagaggat gtcaaaccat 1256341 ttatccatca agaatctgtc attatccctt ttttaaatgg gtaccgccac tatgagcagc 1256401 tatttgcggc attttcaaaa gaacaggtgc tgggcggcct gtgttttata gaaagtgctt 1256461 tagacaacaa aggagaaatt catcatacga gcgcatcgca tcgttttgta tttggagaat 1256521 ggaacggcga gcgtacggag cggataagag cgcttgaaga ggcattttca ggtgtgaagg 1256581 ctgaagtcat cattagcggg catatcgaga aggacatttg gaaaaagtat ctctttattg 1256641 cagcgcaagc ggggatcaca acgttatttc aacgaccgct tggcccaatc ctcgccacag 1256701 aagccggacg tcacacggcc caaactctta ttggggaaat ttgcactgtt ttacgaaaag 1256761 aaggtgttcc ggctgatccg gctcttgagg aagagagctt tcgtacgatg accagcatgt 1256821 cttaccatat gaagtcctcc atgcttcggg atatggaaaa cggccaaacg acagaaggcg 1256881 accacctgca tggatttttg attgaaaaag caaaacgttt atctctcgct gcaccagtat 1256941 tagaaaccgt ttatgcgaat ctgcaaatgt atgaagcaga aaaataaaaa aaggaggcgg 1257001 aaaagcctcc ttttatttac ttaaaaagcc caatttccgt ttctgaagat aggctctctt 1257061 ttcccgtctg ccgtaattcc gtcaatattc atatccttag aaccgatcat aaagtccacg 1257121 tgtgtaatgc tttcatttag gccttctttg acaagctctt cacgagacat ctgctttccg 1257181 ccttcaatat taaaggcata ggcgcttccg atcgccaaat gatttgacgc gttttcatca 1257241 aacagcgtgt tatagaaaag aatgtttgat tgtgatatag gcgaatcgta aggaacaagt 1257301 gccacttcac ctaaatagtg agaaccttca tctgtttcca ccagttcttt taaaatatcc 1257361 tcaccttttt cagctttaat gtcgactata cggccatttt caaacgtcag ggtgaaattt 1257421 tcaataatat ttccgccgta gcttaatggt tttgtgcttg ataccactcc gtcaaccccg 1257481 tctttttgcg gcagcgtgaa cacttcttct gtcggcatat tggccataaa ctcatggcca 1257541 ctttcattca cgcttcccgc acctgcccaa acatgcttcc taggcagctt aattgttaga 1257601 tcagttcctt ctgcttgata atgtaaggca gcgtaatgtc tctcgttcaa atggtcaact 1257661 ttttcatgaa gattttggtc atgattgatc cacgcctgaa ccgggttgtc ttcatttacg 1257721 cgcgtcgctt taaaaatttc ttcccacaga aggtggatcg cttcctcctc tgatttgcca 1257781 ggaaacacct tgtgagccca gcctgctgat gccgcaccta cgacagtcca gctgactttg 1257841 tctgattgaa tatattgtct gtatgtatgt aatgctttgc ctgctgcttt ttggaatgcc 1257901 gcaatccgtt tggaatctat accttttagc aagtctgggt tcgacgacac aacagaaatg 1257961 aaagcagctc catttttggc aagctcttct ctgccttttg cttcccattc aggatattct 1258021 tcaaatgctt caaacggcgc aagttcgtat tttaatttgg cgacttcgtc atcctgccaa 1258081 ttcacggtga cgttttttgc gcccttttca tatgcgtgtt ttacaattaa acggacaaaa 1258141 tcccgaacgt ctgttgaagc atttacgact acatactggc ctttttggac attaacgccg 1258201 acttctaccg ccagctgtgc atatgtattt aatttctgtg aaaatgaatc catgaatcat 1258261 tcctccaagc ttttttctca tcatatcaaa tatgatccta taaaggaaag aaggagccca 1258321 aagtgaaaaa cccaaaacga cacgtcttgg gttttttcaa tattatggat gattcagttt 1258381 tacagtgccg cctgcaggcg aatggggcat atttgccaaa gaaatgctca tgcctccaag 1258441 aataattccg cttaaaatgg ctgcgatcgc tactcttctt cctaaatctc ttagcatctg 1258501 tttcctcctt aacgtttctc catttcccac aatatgaagg aagtgaggaa aaaagaagca 1258561 agaaatttgc cgcgtgtgag aattttgcgg gtaaagacta tttaattgcc ttttgcagct 1258621 tatcaatcac ttctaaagaa cggcctgtgc cgattgctac agattcaagc gggttttgcg 1258681 ccacgtgtac aggcacgaca atctcttctg tgagccattc tttaattcca ttaaggagcg 1258741 cgccgccgcc tgttaaaata acgccgcgat caacaatatc tccgctcaat tcaggcggac 1258801 agtcctcaag tgtcgctctg atggcttcaa gaatatgcag gagggattca cgcattgcat 1258861 cttgaatttc gttggattga agcataatgg tttttggaag acctgtcacg aggtcacgtc 1258921 cccgaatttc cattgcctct ggtatatgtt caatcagagc atggccaatt tccattttta 1258981 cctgctcagc tgtgcgttcg ccgatcagca aattgtattt tttacggacg aaagaaacga 1259041 tatcctcatc aagctggtct ccgccgatcc tgatagaatg gcaggaaaca acgccaccga 1259101 aggaaataat agcgacctct gtcgtccctc cgccgatatc tactaccaca ttggcaaccg 1259161 gctcatcaac cggtaaatcc gctccgatgg cggctgcaac tggctcttcg attaaatgaa 1259221 cgtttttcgc gccgcaattt ttcaccgcat cactgatggc gcggcgttct actgctgttg 1259281 agcctgatgg tgtgcaaacg actacgttcg gttttctgaa cgacatgccg atgctttttg 1259341 cggctttttt cataatgtgc tttagcaggt cagttgtcat atcatagtct gcgatcacgc 1259401 catctttcat cggtctgaca gcgacaattt ttcccggtgt tttaccgatc atgtttttcg 1259461 cgtcagctcc gattgcaagc actgcttttg tcgtcgtatc cactgcgaca acagatggtt 1259521 catttaggat aatcccttta tttttgctgt aaacaagtat attagctgtt cctaagtcaa 1259581 tcccgatttc agttgattga aacatgtttt cacccaatct ctatcctaat ttaatatgat 1259641 tctacattta aagtttctca gaaatactgc gatttttggg ggtgtgcgtc ggtaaagaaa 1259701 tgtttttgta aaaaatcaag gaactgtgta acagaagtaa tacatttttc ggttttatgg 1259761 aaaaaatatc ttgtaattct tatagaaagc gggaaacttt ttcaaagttt cattcgtcta 1259821 cgatatattg aggtacatcc ttaaaacatt acatgagaaa agaaacattt aaaggaagaa 1259881 gggtttttat gaaatcaata ggtgttgtga gaaaagtaga tgaattaggc cgcattgtca 1259941 tgccgattga gttgagacgg gcattggata ttgccataaa agacagcatt gagttttttg 1260001 ttgacggaga taaaattatc ttgaaaaagt acaaacctca tggcgtttgt ttaatgactg 1260061 gagaaatcac ttcagaaaat aaagaatacg gcaacggtaa aattacgcta agccctgagg 1260121 gtgcacagct gcttctcgaa gaaattcaag ccgctttaaa agaataaaat tatgctaaaa 1260181 aaggcggagt gatatcatct ccgccttttt tgcgtgccaa tttttgatta ccgccgccta 1260241 agataagaca tcaagatatt tggtaatgaa tgatttggga tactttacat attttactca 1260301 attatttgtc gaagaatggt acaataagta gagaaacaca agcggcaggt ggtcatatga 1260361 gaaaatatca agctcgtatc atttccatca ttttggcaat gatttttata atgttttggg 1260421 attatttatt ttattttata ggcaaaaacc cgattaattg gcctgttgat attgtgtata 1260481 ctgcagtcac gctggtaagt gtctggatgt tggcttatta tattgatgag aaacagcagc 1260541 tggttaagaa aatgaaggat aacgaatgga agtataaaca gctttctgaa gaaaaaaacc 1260601 gcatcatgga taatttgcag gaaatcgtat ttcaaacgaa tgcaaaaggt gaaattacat 1260661 atttaaacca agcgtgggca tctataaccg ggttttcaat cagtgaatgt atgggaacaa 1260721 tgtataacga ttacttcata aaagaaaagc acgtagccga ccacattaac acccaaatcc 1260781 aaaacaaagc gtcttctggc atgtttacgg caaaatacgt gacaaaaaac ggcacgattt 1260841 tttggggaga agttcattat aaactttact atgaccggga tgaccaattt acaggcagcc 1260901 tgggtacaat gtcagatatc actgagcgga aagaggctga agatgagctc attgagatta 1260961 atgaacggct ggcgagggaa tcccagaaac tatcaatcac aagtgaactt gccgcaggta 1261021 ttgctcatga ggtcagaaac cctttaacat ctgtcagcgg tttcctccag attatgaaaa 1261081 cacaatatcc ggacagaaaa gactattttg acatcatctt ttcagagatt aaaagaatcg 1261141 atttagtgct cagcgagctg ctgctgcttg caaaaccgca ggcaatcaca tttaaaacac 1261201 accagcttaa tgagatcttg aaacaagtca cgacattgct tgataccaat gcaattctgt 1261261 ccaatatcgt catagagaaa aatttcaaag agacagatgg ctgtatgatt aatggagacg 1261321 aaaatcagct gaagcaggtc tttatcaaca tcattaaaaa cggaattgag gcaatgccaa 1261381 agggcggtgt cgtaaccatt tcaactgcta aaaccgcctc tcatgcagtg ataagcgtaa 1261441 aggatgaagg aaacggcatg ccgcaggaaa agctgaagca gattggcaaa cctttttatt 1261501 caacaaaaga aaagggcact ggactgggac ttcccatttg tttgagaatc ctgaaggaac 1261561 atgacgggga attgaaaatc gaaagtgaag ctggaaaagg cagcgtcttt caagtggttt 1261621 tgcctttaaa atcagacagc tgagaggaga aaaataaagt gaactcgctt ctgtttgtat 1261681 acgggacatt aagaaagcat gaaaaaaacc atcatttgct ggcacaatcg gcatgtatca 1261741 atgagcaggc gagaacaaag ggaagtttgt ttgctgcaaa agaggggccc acagttgttt 1261801 tcaatgatga agatgaaggc tatatatatg gcgaagtata tgaagcagat gaattgtgta 1261861 tacataagct cgatcaattt tttcaaggat atcataaaca aacggtgttt gtagaaacgg 1261921 atgtcgggat taaaattgcg cttatttatt ttatgaacaa agacgggtgt gccggtttta 1261981 cgaaaataag cagcggcgac tggaaagaac atcagatgat cagcaaatcg aaaaatccca 1262041 tttattattt tgcctatgga tcatgcatgg ataatgcccg ctttcaaaaa gcgggagtcg 1262101 atcactattt tcaagatcca gtaggaagag ctgttttaaa aggatacaca acccgcttca 1262161 cgctaaaaag ggaagacggt tcaagagcgg acatgttgga agacggagga acaacagaag 1262221 gcgttttata ccgtatccct tattctgctc tctcctatct atataaaagg gagggcgtcg 1262281 aatctcttac gtatcggccg gcatttgtag acgttgaagc tggcggaagg cactacaaag 1262341 actgtttaac ctttctcgtc ctccaaaaag aagcggaaat tgccccgcct cagcactatc 1262401 agattgaaat cgaacgcgga gcggagctgt atttgtcgcc tgagtttact gaaaagctca 1262461 agcggcatat gaattcgctg ccaaaaggat aacactgtaa caaaagaata tgataaaatt 1262521 tgatcaatat catgtcatat aaaggagcac cacgatgaaa aaagaatttg cggtaattgg 1262581 gctgggccgt tttggtggca gtatttgcaa agcattaagc gaagaaggcg tcgaggttat 1262641 ggcaatggat atcgatgaag ataaagtcaa cgagtatgcc aagattgcat ctcacgcagt 1262701 tatcggtgat tcgacagacg aatctgtcct gaaaaattta ggcctgcgaa attttgacca 1262761 cgttattgta gcaatcgggg aaaatattca agcgagtatt ttaacgacac tcattctgaa 1262821 agaacttggc gtccatacga ttacagttaa agcgcagaac gattatcacg aaaaagtgct 1262881 gtctaaaatt ggtgcggatc acatcgtcca cccggaacgc gatatggcaa aacgaattgc 1262941 gcataatatc gtgtccaaca atgtacttga ctatttggag ctgtctgaag agcatagtct 1263001 tgttgaaatc gtagctaaca gccgcctggc tggaaatacg cttctcgatt tagatattcg 1263061 cgcaaaatac ggtattaaca tcgtagccat aaaaaggggc aaggaagtca tcgtatcacc 1263121 gcttgcaacc gaagtcatcc accaagaaga tatactcatt gttattggat cagttacaga 1263181 catctcccgt ttcgaaaaaa gagttcttca tacaaaatag cagccaaata agccgtcctc 1263241 aaagggcggt ttttcatatt atcagaatat aacaacttta atgaactgag cgtcaatttc 1263301 ttaaaatttc attgactaag cacaggcgtt ccgatagcat attgtaccat ataataaaaa 1263361 aaggaggggc ctatttgaat aaagaagcgc tagtcaatag gctgaatgct tcagccaaaa 1263421 gacaaaaagc tgatatcgtc attaaaaacg gaaaaatcat ggacgtatat aatcaagaat 1263481 ggatatatga agatattgcg attacagatg gagttattgt aggcctcggt gagtatgaag 1263541 gcgaaaatat cattgatgca gagggacaaa tgattgttcc gggttttatt gatggacatg 1263601 tacatattga gtcgtcaatg gttacaccga ttgagttcgc taaagcagtg ttgcctcatg 1263661 gcgtgacgac ggttgttaca gatccgcatg agatcgcgaa tgtgtctggt gaaaaaggga 1263721 ttgagtttat gcttgaacaa gctcggcata caccgctgaa tatccatttt atgcttcctt 1263781 ccagtgtgcc tgccgcaagt tttgagcgat caggcgcaat tctcaaagct gccgatctca 1263841 agccttttta tgaagaagaa gaagtattag ggctggctga agttatggat tatgtgtcgg 1263901 ttcagcaggc tgaaaaagac atggttcaga aactgcttga tgcccgtgtg gcaggaaaaa 1263961 ggatagacgg tcatttagct ggtttatcaa cagacctcat taacatttac agaaccgcat 1264021 ttgtcttaaa cgaccatgaa gtaacatcga aggaagaagc ccttgatcgt atcagaaggg 1264081 gcatgtatgt catgatgcgt gaaggatcag tcgccaaaaa cacgctcaat gtgctgccgg 1264141 cggtgaatga aaagaacgca cgccggttct ttttctgtac ggatgataag catgtggatg 1264201 atttattgtc agagggaagt gtaaaccatc aggtgaaaat ggcgattcaa gccggactta 1264261 atccgttttt agcctatcag ctaggaagcc tcaatgcagc cgaatgctac ggattagata 1264321 caaagggagc gattgccccg ggttttgacg ctgatttgct ttttgtatct gatctggaaa 1264381 atgtcactgt cacaatgacg atggtaaaag ggcagactgt tgctgaagac agcaaagcgg 1264441 tctatcagga tcatgcttca actgcagcac cagatcaggc actgcttgat tctgttaagc 1264501 ttgctgctcc tcttaacaaa caggattttc atatgccaat cgattcagag cagcagatca 1264561 atgtcattca aatcatacca aatcagcttg aaacacgatt agtacaagtt ccggctcctg 1264621 ttgcccgcga atttgagcct gacactgagc ttgatttgtt aaagattgca gttgtcgagc 1264681 ggcataaagg attaaaagaa accggacttg gtgttgtgaa aggttttgga ttcaagagcg 1264741 gagcgattgc cacaaccatt tcacacgact cccataatat tattgccgtc ggaacgaatg 1264801 atgaggatat cgcggcggca gttaataagc tgcaggaaat tggcggagga ttaacaatta 1264861 taaaaaatgg ggaagagctc cattcagtac cgctgccgat tgcagggtta ttatccgacc 1264921 aatctgcaga gcaagtgaat caaagcttgc tgacgcttca tgataaattg tcgttaatcg 1264981 gtttcacagg cggatttaat ccatttttga cattgtcgtt tttagcgttg cctgtcattc 1265041 ctgatattaa aatgacgact acgggattat tcgatgtaaa atcatttcaa cacatatcac 1265101 tgcaataaaa agaggcactc ccttagggag tgcctctttt tttaaacctc cataatgatc 1265161 ggcaggatca ttggacggcg ctttgttttt tcgtacaaga aaggtgcaag cgtgtctgta 1265221 atttcgtttt tgatttcaga ccattgagtc gtttttcgtt ccattacttt ttgtaagtga 1265281 tttgaaatga gctcttgagc gtcgttgatc aagtcaccag attctctcat gtacacaaat 1265341 cctctggaaa tcaaatcagg acccgctgaa atcttgaagt cgtccatgtc aatgctgaca 1265401 acaacgatga caagtccttc ttcagagaga attctgcgat cacgaagtac gatattgcca 1265461 atatcaccga taccgcttcc gtcaatgtac actgaaccgg acgggatttt tcctgcaact 1265521 gaagcctcat cgcctttaag tgctaatact tcaccattat ccatgataaa gcagttttcc 1265581 tctgggatgc cacaatctgt tgcaagtttg acatgcatct tttgcattct gtactcaccg 1265641 tgaatcggca tgaagaattt aggcttgatt aaacgaagca tcagcttctg ttcttcctgt 1265701 ccgccgtgac cggatgtatg gatatcgtta agagggccgt gaataacctc agcacccgca 1265761 cgatacagct ggttgattgt tcgactcacg ctgattgtgt tgcctgggat aggggatgaa 1265821 gaaaatacga ctgtatcccc aggattgatt gaaatttggc ggtgtgtgcc gtttgcaatt 1265881 cttgataacg ccgccattgg ttccccttgg cttcctgtac ataaaattgt tactttatta 1265941 gcaggcatac gattgatttc gttatgctca ataaacgtat ttttaggaca gttaatataa 1266001 ccgagtgtct gtccaatttc gatagccgat tccatactgc gtccaaatac ggcaactttt 1266061 cttccatttt gtacagcagc ttcaattacc tgctgcaagc ggtgaatatt cgacgcaaat 1266121 gtggcgaaga taattcggcc gtccaccttg cggaaaatgt catgaatgct ttctcctaca 1266181 cggcgctcag acatggtaaa ctccggattt tcactgtttg tgctgtctga aagaaggcac 1266241 aaaacgcctt ctttaccgat ttcggccatt ttcgttaagt ttgccggctc gccgactgga 1266301 gtaaagtcga atttgaaatc cccagtatgt acgatgtttc cgggcggcgt ttttacaaca 1266361 atgccgtagg aatccggaat actgtgtgtt gttctgaaga atgacacagc cgttttgcgg 1266421 aactttacaa tatcatcctc gccgataatg ttcagtttcg tctgtctcaa taatccatgc 1266481 tcttcaagtt tattccgaag taagccgatc gcgagttttc cgccgtatac aggaatattc 1266541 acttgtctga gcaggtatgg aataccgccg atgtggtctt cgtgcccgtg ggtgataaaa 1266601 agccctttaa ttttatcttc gtttttgact aaatacgtat aatcagggat gacgtagtca 1266661 attccgagca gttcgtcctc gggaaacttg atccccgcat caatcagtac aatttcatcc 1266721 tggaattgca ccgcgtacgt atttttaccg atttcgccca aacctccgag ggcgaaaaca 1266781 gcagtctgat cattttttac aaatttcata ccgctcataa ctccaatact ttaaaatttt 1266841 cgctctgttg ttcatattct aagaatgcac catcaacagg tgtaataaac tcaatattaa 1266901 atttcttttc tttcagcttt gttctgacgt cacgctcaga tacgccttca atataaagtg 1266961 aatctgtctt ttcccgaaca ggtacttcgt cagccttctc ttgataaaat accttataaa 1267021 tcattccaaa tctctcctta aatgccgtat gttagactcg ctcattctat tatattcgaa 1267081 aacggaatat aaggaaagcc ttgagcaaaa taaggatctc tcaaaaagtg aaagatccct 1267141 tgtcaggcaa ttgctttctt acggagcatt ccgttccatt gtcttctgag tttctttctt 1267201 aatttacgca gcattagcca gtccctcctt taatgaaaaa tttgtcccag agttctttta 1267261 tacaaatagt atacggagat tgaggaagac ttttcgtggt tattaatgga atttaatatg 1267321 atttttgaac gaaattgttt gctgaatgac aatctttttg tatgatgagg gtgggaattg 1267381 cagaccaaga cgataaaggg gaagttgcga tggattctaa attaatcttt tttgatattg 1267441 acggcacaat atatgatcat gataagaata taccggaaag tacgagaaaa accgtggcgg 1267501 agcttcagcg ccaagggcat catgtgttta ttgccagcgg ccggtctcca tttttggtta 1267561 agccgatttt ggaggagctg ggcatccact catttatttc ctacaatgga cagtttgttg 1267621 tctttgaaaa tcaagtgatt tataaaaatc cgctgcctga aaatgcaatc aggcgattat 1267681 taaagcaggc ggatgaaggc aagcatcctg ttgtgtttat ggctgaggac acgatgaaag 1267741 cgactgttgc ggatcacccc catgttctcg agggaatcgg cagccttaaa acagattatc 1267801 cagagaccga tgaccttttt tatgaaggaa aagaaatttt tcagcttctt ttattttgtc 1267861 aggatgaaga agaaaaagct tatgccgctt ttcctgagtt tgatctagtt cgctggcatg 1267921 agctatcgac tgatgttctg ccgcacggag gttcgaaggc agaaggaatc aaaaaagtga 1267981 ttgagcgtct tccgtttgat atcggcgata catatgcttt cggcgacgga ttaaatgatt 1268041 tgcaaatgat tgaatacgtt gggacaggcg ttgctatggg aaatgctgtt cccgaactga 1268101 aagaaatcgc ggactttgta acaaaaccgg tggacgagga tggaattgca tacgctgtca 1268161 aagaattggg ccttttaaaa taaagaaacg gctggcattg tgccagccgt tttctctttt 1268221 agcgctcaat tgcgattgca ttttcaggtt ctttgaaagg attttcctta tcaatatgat 1268281 catagaacat aacgccgttc aaatgatcga tctcatgctg aaacacaata gccggaaatc 1268341 cttttaaacg aatatcaata ttttcgcctt ctagtgttgt tccttttact ctgatgcgag 1268401 catagcgggg aacataaccg ggaatcgctt catccacaga gaggcagccc tcgccgcttg 1268461 ttaagtagct tttttcaact gaatggctga cgatcttagg attaaacaga gcatagctgt 1268521 ataatttacc ggaagcatct tccgcatgaa cggcgatcat tcgttttttg atattaattt 1268581 gaggagctgc gagtcctacg ccagggcgca gcttgtattt ttcggctaat tctggatttt 1268641 ggctgttttt aacaaattcg atcatgtcgg ccagctgctg tttttctgca tcagttggag 1268701 gcagctcaac aggttcggca gtctctctga gggctggatg gccgtcacgt acgatgtttt 1268761 ccatagtaat caagaaactt cactcctaaa gcttaatatg taaattatat cggatttctt 1268821 cacaaaggtg caacgaaacg aatgaccagc cgtatatggc tggtcaattt catgctgtgt 1268881 ggttagcaac agcctccacc taaataagca gctccgacaa tgattaacag aatgaataaa 1268941 acaacgatta gcgcaaaggt gcggccgtag ccatatccgc agccaccata tccgtaacca 1269001 ccataactgc agcagcctcc gccgtaacca tatccataca tattacataa cctcctcttt 1269061 taattacgcc agagccttta taagtaggca tagcgtctaa tataacctat gtaaaaacaa 1269121 aaaagttgta tggtcatctg tcctgatttt tcactttttt gatttaattt cagtattgca 1269181 tttatacagc acggctattg ccaaatgtcc ccatggattc tatagtagaa attgtcaaga 1269241 ttgggggatt taacgtgaaa gacgctataa aacggcggcc tggaatcaag atcggagctt 1269301 tttgtgccat ggcactgata ttaacaggat gcatgggaca ggacccggtt gattcacttc 1269361 atcattcatt agaaaaagcc gcggaatcgg aaaagccgtt tcaagaagaa caaaacacac 1269421 tcaaagaatt agaggccaaa gaaaatcagc tttacgatag tgttatgaag ctcaatatgg 1269481 atgattataa aaaaattgtt gctttatcta ataaggcgct tgaaaatgtc agcaagcgcg 1269541 aagaacacct aaagcttgaa aatgacagca tgaaaaaatc ggaaacagaa tttgaggaag 1269601 caaaaacgtc agcggaacat attaaggaaa aagacataaa agaaaaggcc gatgccgcag 1269661 caaaccatat ggagaaaaga tatacatcat atggcactat gtataaagag tataaaaaag 1269721 cgcttgagct taataaaaaa ctgtatatgc agctgaaaga caaagatttg acaagagatg 1269781 atctggatca gcagatcgat aaagtcaatg cttcttatga aaagatcctt aaatatagcg 1269841 gagaatttaa tgaacaaacc gaaaaatata ataaagcccg ggaagattta tatgatgctg 1269901 caggctatcg tgtgaaaaag agctgactcg atcagctctt tttttgaatg aaatgcgatt 1269961 cggatttcgt tcaaaatttt catttctatt gtagtacagc atagtaaggt atactagtac 1270021 agttttgggt gcggttggca tctgtttttt tgatgaaaat gtaaagcgaa tacatttatt 1270081 gaaaatcagc gatgaaaacg attgacggtt cttctttatt tggtgtaaac taatccatgt 1270141 taagcggtgt tgtattagtt ttttacaact tcgaaataat acagttcaaa gcagagtgta 1270201 actatcctac ataaaaggtt ttggcaaact ggggatcggc taaaatataa tacgacttac 1270261 tgctgatact ttagggtacc ctaagtttgt atgtataaaa ggaatgcacg tctaatgact 1270321 gtttaaaaga aaggaagagg tgacttagta tggctgcaaa aacgaaaaaa gctatcgttg 1270381 acagtaagaa gcaatttgat gccattaaaa agcagttcga aacgttccaa attttaaatg 1270441 aaaagggaga agtcgtgaat gaagcggcga tgcctgattt aactgatgat caattaaaag 1270501 agctaatgcg ccgcatggta tttacgcgtg tgcttgacca acgctctatc tcattaaacc 1270561 gtcaaggacg tctcggattt tacgctccta ctgcgggtca agaagcttct cagattgcaa 1270621 cgcatttcgc gcttgaaaaa gaagactttg ttcttcctgg ataccgtgat gtgcctcagt 1270681 taatttggca cggccttcca ttatatcaag cgtttctttt ctctcgcgga catttcagag 1270741 gaaaccaaat gcctgatgat gtgaatgccc tttctccaca aatcattatc ggtgctcaat 1270801 acattcaaac tgccggtgtt gcgctaggtc ttaaaaaacg cggtaagaaa gctgtcgcaa 1270861 tcacttacac tggtgacggc ggagcttctc aaggggactt ctacgaagga attaactttg 1270921 ccggagctta taaagcacct gcaatcttcg tggtgcaaaa caaccgttac gcgatttcaa 1270981 ctcctgttga aaaacaatct gcagctgaaa caattgcaca aaaagctgta gctgccggta 1271041 ttgtcggcgt acaagtagac ggaatggatc cgcttgctgt atacgcagca actgctgaag 1271101 cacgcgagcg cgcaatcaac ggcgaaggtc caacactaat tgaaacactt acattccgtt 1271161 atggcccgca cacaatggct ggtgacgatc ctactaaata tcgtacaaaa gaaatcgaaa 1271221 atgagtggga acaaaaagat ccgcttgtac gtttccgtgc gttccttgaa aacaaaggct 1271281 tatggtctga agaagaagaa gcaaaagtga ttgaggatgc gaaagaagaa attaagcaag 1271341 cgatcaaaaa agctgatgct gaaccgaagc aaaaagtaac tgatttaatg aaaatcatgt 1271401 acgaaaaaat gcctcacaac cttgaggagc aatttgaaat ttatacacag aaggagtcga 1271461 agtaagccat ggcgcaaatg acaatgattc aagcaatcac ggatgcgtta cgcacagaac 1271521 tgaaaaatga cgaaaatgtc ttagttttcg gagaagacgt tggtgtaaac ggcggcgtat 1271581 tccgtgcgac agaaggattg caaaaagaat tcggtgaaga ccgtgtgttt gacacgccac 1271641 ttgctgaatc tggtatcggc ggtcttgccc ttggtttagg cttaaacggc ttccgtccgg 1271701 taatggaaat ccaattcttc ggatttgttt atgaagtaat ggattcagtt tctggccaaa 1271761 tggctcgtat gcgctaccgt tctggcggac gctggacttc acctgtaaca attcgttctc 1271821 cattcggcgg cggtgttcat actcctgaac ttcacgctga cagcttggaa ggtcttgttg 1271881 cacaacagcc tggtatcaaa gttgttattc catcaactcc ttacgatgcc aaaggacttt 1271941 taatttctgc gatcagagac aatgatcctg ttgtcttctt agagcatatg aagctttacc 1272001 gttctttccg tcaggaagtt cctgaagaag aatacacaat tgagcttgga aaagctgacg 1272061 tgaaacgtga aggtactgat ctttcaatca tcacttacgg cgcaatggtt catgaatcat 1272121 taaaagctgc tgatgagctt gaaaaagacg gcatttctgc tgaagttgtc gaccttcgta 1272181 cagtaagccc acttgatatc gatacaatta tcgcctctgt agaaaaaaca ggacgcgcga 1272241 ttgtcgttca agaggcacaa aaacaagccg gtattgctgc aaacgtagta gcagaaatta 1272301 atgaccgtgc gatcctgagc ttggaagcac ctgtacttcg cgttgcagcg ccagatacag 1272361 tatttccttt ctctcaagcg gagagcgtat ggcttccaaa ccataaagac gttcttgaaa 1272421 cagcaagaaa agtgcttgaa ttttaatcaa actgcataat cgagagggaa gatgaacgtt 1272481 ttccctctat tatatatctg ttttcaatgc ttacgatgta aactttaaaa ttgcttaatc 1272541 aaactaggag gtcgagaact gtggcatttg aatttaaact tccagatatc ggggaaggta 1272601 tccacgaagg cgaaatcgta aaatggtttg tcaagcctaa cgacgaggta gacgaagatg 1272661 atgtactggc tgaagtccaa aatgataaag cagtagtaga aattccttca cctgttaaag 1272721 gaaaagtatt agaattaaaa gttgaagagg gaacggttgc aactgttgga caaacgatta 1272781 ttacgtttga tgcacctggt tacgaagatc ttcaatttaa aggcagcgac gagtctgacg 1272841 atgcgaaaac tgaagcacaa gttcagtcaa ctgcagaagc tggacaagac gttgcgaaag 1272901 aagagcaagc tcaagagcct gcaaaagcta ctggcgcagg acagcaggat caagctgaag 1272961 ttgacccgaa caaacgcgtg atcgctatgc cttccgtacg taaatatgca cgtgaaaaag 1273021 gtgtagacat ccgtaaggtt actggttcag gcaacaacgg acgtgttgta aaagaagata 1273081 tcgacagctt tgtaaacgga ggagcgcaag aagctgcacc gcaagaaaca gctgcaccac 1273141 aagaaacagc tgctaaaccg gctgctgcac cagctccaga gggcgaattc ccagaaacac 1273201 gcgaaaaaat gagcggtatc cgtaaagcaa ttgcaaaagc gatggttaac tctaaacaca 1273261 ctgctcctca cgtaacgtta atggacgaag tggacgtaac aaaccttgtt gcacatcgta 1273321 aacagttcaa acaggttgct gctgatcaag gaatcaagct gacttacttg ccttacgttg 1273381 taaaagctct tacatctgca ctgaaaaaat tccctgtttt aaacacgtca attgacgata 1273441 aaacagatga agtcatccaa aaacattact tcaacatcgg tatcgctgct gacactgaaa 1273501 aaggcttgct tgtaccggtt gtgaaaaatg cagatcgtaa atctgtcttt gaaatttctg 1273561 atgaaatcaa tggccttgca acaaaagctc gtgaaggcaa gcttgctcca gctgaaatga 1273621 aaggcgcatc ttgcacaatt acaaacatcg gttctgccgg cggacaatgg ttcactccgg 1273681 ttatcaacca tccagaagtt gcgattcttg gtatcggacg cattgcagaa aaagcgattg 1273741 ttcgtgatgg cgaaatcgta gcagctccag tcttagctct ttctctcagc ttcgaccacc 1273801 gtatgatcga cggagcaact gcgcaaaatg cattaaatca catcaagcgt ttactgaacg 1273861 atccacaatt aattttaatg gaggcgtaat gttatggtag taggagattt ccctattgaa 1273921 acagatactc ttgtaattgg tgcgggacct ggcggctatg tagctgccat ccgcgctgca 1273981 cagcttggac aaaaagtaac agtcgttgaa aaagcaactc ttggaggcgt ttgtctgaac 1274041 gttggatgta tcccttcaaa agcgctgatc aatgcaggtc accgttatga gaatgcaaaa 1274101 cattctgatg acatgggaat cactgctgag aatgtaacag ttgatttcac aaaagttcaa 1274161 gaatggaaag cttctgttgt caacaagctt actggcggtg tagcaggtct tcttaaaggc 1274221 aacaaagtag atgttgtaaa aggtgaagct tactttgtag acagcaattc agttcgtgtt 1274281 atggatgaga actctgctca aacatacacg tttaaaaacg caatcattgc tactggttct 1274341 cgtcctatcg aattgccaaa cttcaaatat agtgagcgtg tcctgaattc aactggcgct 1274401 ttggctctta aagaaattcc taaaaagctc gttgttatcg gcggcggata catcggaact 1274461 gaacttggaa ctgcgtatgc taacttcggt actgaacttg ttattcttga aggcggagat 1274521 gaaattcttc ctggcttcga aaaacaaatg agttctctcg ttacacgcag actgaagaaa 1274581 aaaggcaacg ttgaaatcca tacaaacgcg atggctaaag gcgttgaaga aagaccagac 1274641 ggcgtaacag ttactttcga agtaaaaggc gaagaaaaaa ctgttgatgc tgattacgta 1274701 ttgattacag taggacgccg tccaaacact gatgagcttg gtcttgagca agtcggtatc 1274761 gaaatgacgg accgcggtat cgtgaaaact gacaaacagt gccgcacaaa cgtacctaac 1274821 atttatgcaa tcggtgatat catcgaagga ccgccgcttg ctcataaagc atcttacgaa 1274881 ggtaaaatcg ctgcagaagc tatcgctgga gagcctgcag aaatcgatta ccttggtatt 1274941 cctgcggttg ttttctctga gcctgaactt gcatcagttg gttacactga agcacaggcg 1275001 aaagaagaag gtcttgacat tgttgctgct aaattcccat ttgcagcaaa cggccgcgcg 1275061 ctttctctta acgaaacaga cggcttcatg aagctgatca ctcgtaaaga ggacggtctt 1275121 gtgatcggtg cgcaaatcgc cggagcaagt gcttctgata tgatttctga attaagctta 1275181 gcgattgaag gcggcatgac tgctgaagat atcgcaatga caattcacgc tcacccaaca 1275241 ttgggcgaaa tcacaatgga agctgctgaa gtggcaatcg gaagtccgat tcacatcgta 1275301 aaataatttt catatcaaaa acagccccgc tttgagcgag ggctgttttt ttattttgac 1275361 agcacatgct gtaatggttt aatgatgtct tctttctttt tcacacatcc ctcgattttc 1275421 accacgacat ggcgctgatc aacaaccata agggtaggga cagtttcaat ctcatcttcc 1275481 cagccttctt ttttatcata gaccttcatt ttatctattt gctcgggata atctttttct 1275541 aaatcaagca gtgcatcgta ataaggcgct tcctggtcta tttggttctc atcagaaaaa 1275601 aacaggattt gtgtatgatg aatgttgtca atccggcttt ttttcatcgg attgatggtg 1275661 gaaagcgtac agcccgataa agcaaatact attatcagca tggggaatac cgcgcgatat 1275721 cgcatctatc ttctcctctg tataaacagt agttaactag ctttagttta tcacgagaga 1275781 cggcttaatc tgcttcttgt tacctaattg ttatataatt gaaaccgttt ttaaagtgag 1275841 attacatatt atatcaatcg tttaaaatag caacctgggg tatattgaat tttttgctgc 1275901 attcttggat gaaagttcaa gaaaacgtgc aattacatta tgtgctgtgg catatatatc 1275961 gagtaaagct tctgtatgaa gaagatattg tatgatggaa aatggaaaaa caaggtgaat 1276021 atgatgatat gaaataaaat gtgttataca gtttgttgtt gacattttaa atgtgacata 1276081 ttaatataat aacaacaaaa gaaattaagc gttttcaaat ttcaaagaaa tggggaataa 1276141 gagatgggta cgattgtttg ccaagattgc aacgaagcca ttcattactt tgaagatgag 1276201 aaagtgacaa cattatatgg aacttgctgc ggacaatgtc aatgtcctgt tgatgaagag 1276261 taaaaaaaag catgcggctt aaagccgcat gctttttatt ttttattgaa ttgctttttg 1276321 ttctttgatg acccggatca tatgtaaagt cgagtcctca ggtccttgaa cagggaggcc 1276381 tgcgtcaagg tttttaaaaa tgtagctgat gttttcttct gtaataattt ctcctgggat 1276441 gaagattgga ataccaggcg gatataccat gacaaattca gcaataatcc gtccggatgc 1276501 ttcttttaat gggatgactt ccgtatttgc atagaaagca tcacgcggag tcattgccaa 1276561 taaaggtatt tctggaagca gaacctcagt ttgctgatgt gttacatctt gttctgacat 1276621 ttgctgtgcg atctcagtta aagcctctac aagccggtct gcatcatttt ggctgtcacc 1276681 aggagtgaaa atacacaaaa tattgtacag atcagaaagc tccacctcaa tattaaagga 1276741 ttcacgaagc catttttcca cgtcatgtcc tgtcaggcca agacttttca cagagataat 1276801 caattttgtc ggatcatagc tgtaagctgc tttcgaccca agaatctcag aaccgacaca 1276861 ataaatgcct tcaatctgat tgaggcgatc tctcgtctga ttggcaagct tgagtgtttc 1276921 ctcagcaagc tggcggcctt ctgttgcaag gcgttttctg gcaacatcca aagaagcgag 1276981 aagcaagtaa gaagttgacg tagttgtcag catgctcagg atggattgca ctctgtcttt 1277041 agatacaagg ccttctctca tgtttaaaat agagctttgt gtcagtgatc cgcccagctt 1277101 gtgtacactt gtcgctgcta tgtccgctcc tgcctgcata gccgatagcg gcaattcgtc 1277161 gtgaaaatga atgtgaacgc cgtgtgcttc atccacaagc actggcacat caaacgaatg 1277221 agcgagttct acgatgcttt ttaagtcggc tgcaacaccg aaatatgtcg ggttgatgac 1277281 gagaagccct tttgcatccg gatgctcggt aagcgcccgt ttagcagatt caagtgtaat 1277341 tccgtgggag atgcccaatt cattgtcaat ttcaggatga ataaaaattg gaaccgctcc 1277401 ggaaaataca atagctgtca taattgattt atgaacattt cttggaataa taattttatc 1277461 accaggtccg caaacagcca ttaccattgt cataatggcg ccgcttgttc cttgaacaga 1277521 aaaaaatgta tgatccgctc caaatgcttc agcagccaga tcttgtgctt gtttaataat 1277581 gccttttggc gcgtgcagat cgtctaatgg ttcaatatta atcaaatcta tgcttaacgc 1277641 gttttcaccg ataaattgtc tgaattctgg gtccattcct gccccttttt tatggccggg 1277701 aatgtggaat tgaacaggct gtctgcttgc atgctttttc agtcctgtgt ataagggtgt 1277761 ttcatgttgc gacaattgtt ttcccacctt tgtaatcata cctatgcata atagtgtgta 1277821 ttaaaatcag tttctcaacc gttttttaga cgtaaaacaa atgaattata ttatgaactt 1277881 gaaagaatgt aaagctagac aaaattgata gtattgtcct gtgtttgttt ttgttgaata 1277941 atatcaagat gagtcaagtg tcatgtggtg gttcattcaa gagttatgtt ttttacatat 1278001 caaggggaag atgagatatt tttgtttcat cttgaaactt tttgaaaagt ccgctgtcta 1278061 accgaatgag gccttaataa gaagtaaagg attgttgttc gtgttggagt tattcagtca 1278121 ttatgtattg catttcgaac gttattttat attaagcaga caaagcaccc tgctgattca 1278181 atggtcaatt gttgttctgg cgggcttata tcttttggtg catcatccca aaataaaccg 1278241 gcagcgcaca atgttcttgg cgggtgttat attgcggatt gtgctgctgg cgggagtgtc 1278301 tgttgaactt attcaccagg tgcaatcaac aaacttcacc agcgcttact taagagagga 1278361 cggaaaagaa ctgctgccgc tgctgcattt tttgttatac ggatatgtgc tgctgacggc 1278421 ttttcactat atgctgatgc cgcgtgatca tggcggaaag ggtaagtttt atacgttcga 1278481 ccttgctgtt gtcagtttgc cgatcgtaca aatgattttt agtttctttt cgtattggaa 1278541 ggaatacccg gatgggatgg agccgattgc attcgtgttt ctgtttttca tcatcactct 1278601 tcccattgcg ttgaatgtag tgtttttcaa gctgtattgg agaacggata agatcttact 1278661 aggcttattt tatacgctga ttatcggact gcttgtcttg ctgcttgcgc catatcccaa 1278721 tcaaatctca aaagattatg gtgcagtaat gccatatacg atttatttgg caatggcggg 1278781 atttttgatg agctatcatc tgttccaaaa gtcaggaaag gtttatgtgc gtgtgaataa 1278841 gtgggtgacg atggctgtca tggtgttttt tgtcctgctg ttaaatccga tatataacat 1278901 aggaacggct gctttcgctg tatcaaagcc agcaaatgtc catgattcat tcaattttgt 1278961 cggggagcac atttcatcag aaaaagcgga acagatacta aagtcatttt ttcctacgga 1279021 tgaaacactt tatttgcacg atacaaacat ggatgtgcat tatttctact catttgaaag 1279081 caaaggttac aaagctgagg tagatgaagt atcgcagcta attcgtaatt atgaatactt 1279141 acaaaaagca catgggaaaa agctaacgaa tcaggagtac aagcgaaagt ccatcgcttt 1279201 ccttgagcga cacggacgtg tgttacataa ggatcatatc gaaacaaagg tatctcaaga 1279261 agacggccag acagtcgtac gtatttacct gaaaaatcaa cttcataaaa aagatcatgc 1279321 tgatgatggc gcggtatttt attgggaaaa ggaaacctta atggggttta gtgaagatcc 1279381 ttcgatttat cagcttgact ctcttctgca tgttcatata acggaacaag acattcacga 1279441 caaagtggaa caaatgttta cagcgctgaa catatcaaaa cagccttatc agatcactga 1279501 tattgaaagc gacagcctgc ttggaagcat ggtgagagtt gaaacaaaag ttggaattgt 1279561 tttggaattt gagggcgaat caggttgttt acatagtctt tcgcttccga tgaaaaagaa 1279621 tatctcaatg gctaacagcc ggctgcagca tcagatatta tcgatcttcg atgctcgtgg 1279681 atcagaaaag aagaaaaaaa gcagtcaggg tgacatggtg atgtatactg attcttctaa 1279741 aacatatgag tttgttgaag ctcaaggtca gctaaacgtt tatgtataca gcgatacacc 1279801 tgatcagtca ttcccctata cgtatcgtaa tggaacattg gcttacgaaa aagtagcttc 1279861 tctatatcag gatgtcattt acaaaaagcg tatgcgtccg attatcgttc aaagagggga 1279921 tgaacggcat tatgcatggc tgatcattat tcagccgttt ggttcaaatc gccatgatgc 1279981 ctatgtagtg gatggagaaa cacaagaggt gaaaagtctt tatgaatcat aaagaaaaag 1280041 agtctgtttt tgtagactta tacgacctgt ataaagaagg agagctagag gatgaatcaa 1280101 tggaatggat gaaacagcat gaatccctat ttcaaaagaa tgcggaagac ttaaagagta 1280161 aaacttgttt aaagagaagt cccggtgctg aagaagaaag ccaaatcaga tatatgaaag 1280221 tatacctgtc ttccatgtat atctgtttca ttttattggc catttggatg acggtgtggt 1280281 tttattttta atgaagcata gggattccat tgaggacttg tatcggcagt attatcaaga 1280341 aattttaaat tatttattca gaaggactca tcatcttgaa acagccaagg acttagcgca 1280401 ggacacgttt gtaaaagctc ttaacggtct ggcttcgttt agggggcatt cttccatcag 1280461 aacatggctc tacaccattg cgcatcatac ctttatcaat tggtaccgaa gggatgtcaa 1280521 ataccaattt actgaaatca gcaaaaatga agggttaacg caaacaactt atgaccagcc 1280581 tgaacagtat ctgtcacgga cggtgaaaag cgaaacactg cggcaggagc tcctgaagtt 1280641 aaaagatcag catcaatccg ttttgatttt aagagaattc caagagcttt cttatgaaga 1280701 aatcgctgag atattaggat ggagtctttc taaggtgaat accacattgc accgggctag 1280761 attagagcta aagaaaaaca tgacgaaaag tagagaggag gagcggatat gacctgcttt 1280821 ctagtaagag acctgcttcc tctgtatctt gaaggtgatt gtaaaagaga aacggaacac 1280881 gttatagaag agcatttaaa aatgtgcagc agctgcagag acatgtatga cacgatggct 1280941 gagccatttg aattggaaag cgaacaggcc gttgaggagg cttatctgcc ggaagaagaa 1281001 ctgcgtttta aacagaggta ctatggatta ctgatcatga aagctgcctg ctggtttgga 1281061 gcggcggttg ccatgatgct gatcatcaaa ctgctgatat aaaaaaagcg cttgtccgat 1281121 tccggcaagc gcttttttac attaagcctg gggatgaatc atatcgtaaa tagcggcaag 1281181 ctgttcttgt gacagggcac tgaagagttt ttcataaacg tcagcttgca gtggcgttgc 1281241 acctgcttgt agcgctgcgt ctttatcata gctgtacaca tcatcttgta gcacaatggc 1281301 tgcttgaaga atgtgaatct tgagagaaac agcggagaaa aattgttcaa gtgcaagtgc 1281361 ttctttttct gtgaagccaa gttcaactgc tttttctgta tcaaatttgt aatttccatc 1281421 ctcgagatac acacattgtg aaacaatgct gaaaaattct gatgtcgatt cccagagtgt 1281481 agcaattacc tgagcctctt cttttgtcat tcctaactcg acagcttttt cgctgtcaaa 1281541 ataatataca ccgtcttgtt cgtatataca ttgatttaat atatcaatga atgtattgag 1281601 atcttcgtta gtgctcgcct gatgctggag ttgaacagca gtgttatcaa ccggtgtttt 1281661 tgcgctggct gcatcaggac cgaacgttaa tagagcagct gaggtcattg cggcagtcgt 1281721 taacatagct ttttttacaa atgttttctt catgtttctt ctctcccttt tatgaattgt 1281781 gctacaaatt ccattatagg gagtagtttc cggtggagga ataggcgcta tggtatttta 1281841 tgtgtatcgt tgccgaacta ctttttgaag gctgcacgtg tgatcgttag aacgattgtc 1281901 tatgtatgaa ggctgttttg catcttcctg actaagaaac aggggagata aggcttaaag 1281961 aaatgaaaaa caccgctttc tttgcggtgt tttttgatta caatgtcgcc ggcggggcaa 1282021 tgcttttaat caagcaagcc ttgttcgcgc attttctttt ttaatgtaaa tccgccgccc 1282081 atgacagcgc aaacaagtac aatgctggcg ataatgcctg cagggctttt ttcagcgata 1282141 aagacgccga tcagcataat gctgaaaacc gctgcaaatg caaataatag taaaagccaa 1282201 ttcatttttt tcataaattc catccccttt tacgtcttat attaagttta cagaaaaacg 1282261 tgacgctttt aaagaggatg tgtgatataa tatgaaagtt atctaatttt tttaggagat 1282321 gaaaaagtga aacttcgaaa tgatcttcgc aacatcgcga ttattgccca cgttgaccat 1282381 gggaaaacga ctctagtcga tcagctttta catcaggctg gtacgttccg tgccaacgaa 1282441 caggttgctg aacgcgcaat ggactctaat gatcttgaac gcgaacgcgg cattacaata 1282501 ttggcgaaaa atactgcgat taactataaa gatacacgta tcaatatttt ggacacccct 1282561 ggacatgcag actttggggg agaagtagaa cggattatga aaatggttga cggcgtagtg 1282621 cttgtcgttg acgcatatga aggctgtatg cctcaaactc gttttgttct gaaaaaagct 1282681 cttgagcaaa acctgaaccc tgttgttgtt gtaaacaaaa ttgaccgtga ctttgctcgt 1282741 ccagaggaag ttatcgatga agttctggat ctgttcattg agcttgatgc caatgaagag 1282801 cagctcgagt tcccagtggt atatgcttcc gcgattaatg gaacagcgag tcttgatccg 1282861 aaacaacagg atgaaaacat ggaagcttta tatgaaacca ttattaagca tgttccggca 1282921 cctgttgata atgcagagga gccgcttcaa ttccaagttg cccttcttga ctacaacgac 1282981 tatgtaggcc gtatcggaat cggacgcgta ttccgcggca caatgaaagt cggacagcag 1283041 gtttctctta tgaagcttga cggaacggca aagtcattcc gtgttacaaa gatttttggt 1283101 ttccaaggct taaagcgtgt ggaaattgaa gaagcaaaag cgggagacct cgttgcggtt 1283161 tccgggatgg aagatatcaa cgttggtgaa acggtatgtc ctgtagacca tcaagatccg 1283221 cttccggtcc ttcgcattga tgagccgaca cttcaaatga catttgtcgt gaataacagt 1283281 ccgtttgcag gccgtgaagg caaatatgta acggcccgca aaatcgaaga gcgtcttcaa 1283341 tcacagcttc agacggatgt gagcttgcgt gttgagccaa cagcttctcc tgatgcttgg 1283401 gttgtttcag gacgcggtga gctgcacttg tcaattttaa ttgaaaatat gcgtcgtgag 1283461 ggctatgagc ttcaagtgtc aaaacctgaa gttattatca aagaaatcga cggcgtacgc 1283521 tgtgagcctg ttgaacgtgt gcaaattgat gttcctgaag agcatactgg ctctgtaatg 1283581 gaatcaatgg gtgcccgcaa aggcgaaatg gttgatatga tcaacaacgg aaacggccaa 1283641 gtccgtctca tctttacagt tccttcccgc ggattgatcg gttactctac agaattccta 1283701 tcattaacac gcggattcgg tattttgaac catacgtttg acagctacca gccgatgcag 1283761 gcaggccaag tcggcggacg ccgtcaaggt gtacttgtgt caatggaaaa cggaaaagca 1283821 acatcatacg gtattcaagg aattgaagac cgcggtgtca tcttcgttga gccgggtact 1283881 gaagtatacg aaggaatgat cgttggagag cataaccgtg acaacgacct tgttgttaac 1283941 gtcagcaaaa tgaaacagca aacaaacgtc cgttctgcga caaaggatca gacaactaca 1284001 attaaaaaag cgcgcatcat gtctcttgag gagtctctag agtacttaaa cgaagatgaa 1284061 tattgtgaag taacacctga atccatccgt ttaagaaaga agatcctcaa taagaacgaa 1284121 cgtgaaaaag cagctaaaaa gaaaaaaaca gcaggattgt cttaatctcg tgcagaattt 1284181 gaaaagatag aacccgtacg tttacagggg agggaatctt tttgaatgac gtaagcgaac 1284241 gcctgtcgtt cttcgccgct ctatatcaag tagaccggca gcctgcggca ggcatgtggc 1284301 tgctgtacgg cacgattttt gtgttggccg ttattgtatt taagcttgga tttgctaaac 1284361 ggcttcctgt attaaaatct gcagtggtgt atgtattttt ggctttgggc tgcactgttt 1284421 tgactttttt aggggtgttt ttgcccgtgg cagaaggatt ggtcgtcgct gcgctgattt 1284481 taatcattta caaaatccgg ctgtatcagt cgaaaaaagg acagtctgca aaatcataaa 1284541 agactcagct gaaagctgag tcttttttgt gttctgtatg gttaagcggc cgctttattt 1284601 tttgactttt tcttttttct gctgtcccgg gtgaaaagta aattttcccg ttttcagccg 1284661 ttcctctgtt tttttggcaa tccgatcgtg gcattcctgg cacatatatg tatggatcgg 1284721 gcggtttcga agccgtttcg cgatcagggt atcatcatca attgtttcaa ttttatcgca 1284781 aatagaacat ttgaccctca tcatatcacc tctttcacta acatgtatta taccacggat 1284841 cagaagctgt ccaaaataag aaaaagctaa agcgcaaggc tatagcttag tcattgttgt 1284901 tctttttcat atgatgatca gattgatcgt tttgttcctt ctccatttcc tgttgctgtt 1284961 ttctatttaa ttggtcattt tgctgctttg tttgcggttc atcttcattg tcaatcacat 1285021 cgttaggcac ttcgggaagc actcggccga caattgcagc taattcatcc agtatacctg 1285081 ttaccggatg gccctcgctg atttctctgc tcatttcgcg aaggcggctg accgtatcgg 1285141 gatcagcaat gactactgcg ttggcgccat atcgatcatt ctttagcgcc tgagctacag 1285201 aatatttaat ggtttccact ttgcttctgt ccaaagtatc atcgacatca atcccaacaa 1285261 cagcatagcc tcccagcaca acggctgttg catccttgac gtcggggttt ttttcagcaa 1285321 cgctgacaag atgcttggca atatccgttc ttgttccatt gtcttttgtt tcttgagttg 1285381 tgtcctttac gtgaatcggt ttagtctcct gctgtcttgt tgattctttt tcaacattct 1285441 ggccctgttt tccttgttga taggcacaag cggacaggat aagtgtcagc tgtatgataa 1285501 tgaaaagaat tcgcacttgc gggttccctc cttaaaatgc tttcattaat tttattgttg 1285561 aattaacctt ctatctttat gcacaaaaac atatatttta gcaggcattc acctttttca 1285621 tcaaaagaga agcaggaaga actttgaccc ttatatcagg aggctgagac ttgagtaaaa 1285681 tttatgtgtt agatacgaat gtgttattac aggatcctaa cgcgatattt tcttttgaag 1285741 aaaatgaggt tgtcatccct gctgtcgttt tagaagaggt tgattcaaaa aaacggtata 1285801 tggacgaagt tgggaggaat gcaaggcacg tatctaagct aatcgatgcg ctaagacaaa 1285861 agggcaggct gcatgagcat gtaccgcttg acaccggcgg cacactgaga attgaactga 1285921 atcatcgttc gtttcaccag ctgcaagaga tctttattga aaagacgaac gataatcgca 1285981 tattagccgt tgcgaaaaac ttaagcctcg aggaagaaac caaggaaaat ggcaggccgg 1286041 ttatccttgt cagtaaggat gtactggtca gggttaaagc cgacgcaatc ggactgcttg 1286101 ctgaagattt cttgaatgac cgggttgtgg acaatgatga aatgtacagc ggctataaag 1286161 atttatatat cagccagcag ctgttcagct ctttttacgg gaaaaatcaa atttcagtaa 1286221 acgatgtgaa acagcatgcg ttttatccga atcagtttgc tttaatgaag gatgagctag 1286281 gagggtcctc ctcggcagtc ggaattgcag acaaaaccgg aacggtatta aaaagactcg 1286341 tatttgatga tgaacatata tggggaatca ggccgaaaaa tgtacagcag acaatggcat 1286401 tagagctttt gctgcgggaa gatattccgc ttgtcaccct gatcggcaaa gcgggaaccg 1286461 gcaaaacgct cttagctttg gcggcagggc tattacagac agaagacttg ggaatatata 1286521 aaaagctggt cgtcgcaagg ccgattgttc ctgttggcaa ggacatcggg tatttgccag 1286581 gcgaaaaaga ggaaaagcta aagccttgga tgcagccgat ttttgacaac ttagagtttc 1286641 tgtttaatgc gaaaaaacca ggggagcttg atgctatttt ggcgggaatt ggctcaattc 1286701 aggtagaggc gctgacttat atcagaggga gaagcattcc agatcaattt attatcattg 1286761 atgaagcgca aaatttgacc aggcatgagg tgaaaacgtt gctgacgaga gtcggtgagg 1286821 gcagtaaaat tgtcttaatg ggcgaccctg aacaaattga tcacccatat ttagacagtc 1286881 tgaacaatgg tttggcctat gtggttgagc ggtttaaagg acaacccatc tcaggcagcg 1286941 tgaagctgtt aaaaggtgag agatcaggtc tcgcccagct tgcagctgat ttgctgtaac 1287001 acttaaatga tttcgatctc ttttacatcg gtaatcggct gtttgtgatg aaccgggtct 1287061 tcaaagtaaa tatgcacggg gccgccttct tgaatcggct tgcctgcctc actgaaatgg 1287121 acaatactgt tcagagcggt ttccagagaa acggcggcct ttcccgaact tgtgacaaat 1287181 acacattgtg tcgcagagct gttcggctca gcatttttca ggacagtccc aagtctcatt 1287241 gcgaaactgc cgttcatcag tttttgcttc tcatattgct tttccgtctt taatgtaggc 1287301 ggcgcgattc gcccctctct gatgacgcgt tccggatcaa ggtcggattc atccccggct 1287361 gattgtaaat atgtgtcttg actgtcccct ttgcggtcaa acgaaaattt gcgatcatca 1287421 aaaatccata cgcttggatc aatggtaatt ggatatgtaa cattgccttt tacttggata 1287481 acgctcatga tatgaccccc ttctctcaaa attataaaag ttttcgcatg aattgtcact 1287541 ttgtgtacaa attatgtgta ttgaaatgct gagggaacga gggtgtttgc atggtatgcc 1287601 agcataatga tgagcttgaa gccttagtga aaaaggcgaa aaaagtaacg gacaaggggg 1287661 aggtagccag ctatattccc gccttggcaa aagctgataa acacgacctg tcagtggcga 1287721 tttattattc caataatgtt tgtctgtcag caggtgacgt agaaaaaaca tttacgcttc 1287781 aaagtatatc gaaagtcctt tcccttgctt tggtgttaat ggaatacggc aaagataagg 1287841 tcttcagtta tgttggacag gagccgaccg gtgatccgtt taattcaatt atcaagctcg 1287901 aaacagtgaa tccgagcaag ccgttaaacc ctatgattaa tgccggggca ttggtagtga 1287961 caagtctgat aaggggaaga acggtaaaag agagacttga ttatttgctt tcttttatca 1288021 gaaggctgac aaacaaccaa gagattacat actgccggga agtggctgaa tctgaataca 1288081 gcacttcaat gattaatcgg gcgatgtgtt attatatgaa gcagtacggc atttttgaag 1288141 atgatgtaga ggcagtaatg gatttatata cgaagcaatg cgcgattgag atgaacagct 1288201 tggatttagc gaaaatcgga tctgtattcg cattgaacgg cagacatcca gagactgggg 1288261 agcaggtcat ctcaaaagat gtcgctagaa tttgcaaaac gtttatggtg acgtgcggaa 1288321 tgtacaatgc aagcggggaa ttcgcaatta aggtcggaat tcctgcgaaa agcggcgtat 1288381 ccggcgggat aatgggcatt tcgccttacg atttcgggat cggcatattc ggccccgcat 1288441 tagacgaaaa agggaacagc attgcaggtg taaagctttt ggaaataatg tctgagatgt 1288501 acaggctgag tattttttaa tttatgtcat atgcttaaat cctcttgcat tttctgttga 1288561 taccctttat gataaataga agaattaggt actcgcctgg ggaacggagg gatacttttg 1288621 gcttcagaga tgatagttga ccatcggcaa aaagcttttg aactcttaaa agtggacgct 1288681 gagaagattt tgaagctgat ccgagtacaa atggataact taacgatgcc tcaatgtcct 1288741 ctatatgaag aggttttaga tactcaaatg ttcgggcttt cgagggaaat cgattttgct 1288801 gtccgcctgg gattggttga tgaaaaagac ggtaaagacc ttttatacac attggagcgc 1288861 gaattgtctg ctttgcatga cgcgtttaca gctaaataaa tgataaaact caaacttatt 1288921 aacagtttgg gtttttttat aaccgctatt tttctctcat ctcataaaag acggtctttt 1288981 tttacacatt ccttccgaat cgtatagaga ttcttcgtct cgtttgataa attgtagtaa 1289041 aataaaaaag ataaatacat aaaaaccata gataatggaa gttagaagca gggaagagga 1289101 tgttatgtta aaaaaaatgc taaaatctta tgattactca ctgatattcg caatcgtttt 1289161 attatgcgga ttcggtttag tgatggtata cagctcaagc atgattacgg ctgtctcccg 1289221 gtatggagta agcagtaatt ttttcttcat gcggcagctg tttgctttaa ttgcgggtgg 1289281 cgctctattt attctcatgg cgttgtttcc ttataaagca ctggcccatc aaaagtttca 1289341 gaaggggata ctgcttgtat ctgttcttgc gcttatctca ctgtttgttt tcgggcatgt 1289401 tgccggaaac gcgcagagct ggtttaaaat cggcggaatg agtattcagc cgggggagtt 1289461 tgtgaaactg gtcgtgattt tataccttgc agccgtatat gcaaaaaaac aaagttatat 1289521 cgaccatctg ttaacgggag tagcccctcc ggtagtcatg acgcttataa tttgtgggtt 1289581 aattgccatg cagccagatt tcggtacagc catgattata gggttaattg cgacgtgcat 1289641 gatcttgtgc tccggcttca gcggaaagac gctggtgagg cttgtgatac tgggcggaat 1289701 tgttttcatt ttagtcagcc ctattatcta tttgaatcag gacaaaattt taactgaagg 1289761 ccgtttagcg cgttttgaga gtcttgaaga cccatttaag tatgcaaatt catcaggttt 1289821 gcaagtgatc aattcttatt atgcgatcag ctcaggcggc attttcggcc tggggctcgg 1289881 tgaaagtatc caaaaatacg gatatctgcc tgaatcacac actgacttta ttatggctgt 1289941 cattgctgaa gagctcggca tttttggggt attgtttgtg attttcttat tgggttttgt 1290001 cgtcataaaa ggtttttata ttgccagaaa atgcgaggac ccgtttggaa gtcttctggc 1290061 gatcggcatt tcaagcatga ttgccatcca gtcgtttatt aaccttggcg gtgtcagcgg 1290121 attaattccg attacagggg ttacgctgcc atttatcagt tacgggggct cttctttggt 1290181 gctgctgctg gggagtatgg ggatattagc gaatatcagc atgtttgtga aatattcaga 1290241 gaataagaaa aagaaagagc ccttggcgcc gaagggaatg aaaaagaaac agctcaaaaa 1290301 aactgtttat ctgtaaaaaa caagtgtgta caggggaagg atattccgct atgatagatt 1290361 atattccatt cgggtaaggg ggagaaaagt ttgtctcagc aatcgataca aaaagtatta 1290421 gtagcaaaca ggggagaaat tgcaatccga atattccggg cgtgtaccga gttgaatatt 1290481 cgtacagttg cggtctattc aaaagaagat tccggttcct accatcggta caaagcggat 1290541 gaagcatact tggtcggtga agggaaaaaa ccgattgatg cttacctgga tattgaaggt 1290601 atcattgata ttgcgaaaag aaacaaagtc gatgcaattc atccgggata cggtttctta 1290661 tctgaaaata ttcattttgc gagacgatgt gaagaagaag gcatcgtatt catagggcca 1290721 aaatccgagc atctcgatat gtttggtgac aaggtaaaag cgcgtgagca ggcagaaaaa 1290781 gcgggaatcc ccgtgattcc gggaagcgac ggtcctgccg aaacgcttga agccgtcgaa 1290841 caatttggac aagctaacgg ttatccgatc atcattaaag cctcgcttgg cggcggcggc 1290901 cgcggtatgc ggattgtcag atctgaaagt gaagttaaag aagcatatga gcgtgctaaa 1290961 tcagaggcga aagcagcctt tggcaatgat gaagtttatg tagaaaaatt aattgagaat 1291021 ccgaaacata ttgaggttca ggtcattgga gacaagcagg gcaatgtcgt ccatcttttt 1291081 gagagggatt gctccgttca aagacgccat caaaaagtca ttgaagtggc gccgagtgtc 1291141 tcgctgtcac ctgaattaag ggaccaaatt tgtgaggctg cagttgcgct tgccaaaaat 1291201 gtaaactata taaatgcggg gacggtcgaa ttccttgttg caaacaacga gttctacttt 1291261 attgaagtaa atcctcgcgt acaagttgaa cacacgataa cagaaatgat tactggtgtc 1291321 gatattgttc aaactcagat ccttgttgcc caagggcaca gccttcacag caaaaaagta 1291381 aatattcctg agcaaaagga catttttaca atcggctatg ccattcagtc acgggttacg 1291441 actgaggatc cgcaaaatga tttcatgcct gatacaggaa aaatcatggc ttaccgctca 1291501 ggcggcggtt ttggtgtccg tcttgatacc ggaaacagct tccagggcgc cgtgatcaca 1291561 ccatactatg attcacttct cgttaagctt tcaacttggg ctttaacgtt tgaacaggca 1291621 gctgccaaaa tggtgcgaaa ccttcaggag tttagaatca gaggcataaa aacgaacatt 1291681 ccgttccttg agaacgttgc aaagcatgag aagttcctga cagggcaata tgatacatct 1291741 ttcattgata caacgcctga attatttaat ttccctaaac aaaaagaccg cggaacgaaa 1291801 atgctcactt acatcggcaa tgtgacagtg aacggcttcc ctggaatcgg gaaaaaagaa 1291861 aaaccggcgt ttgacaaacc gttaggcgta aaggtagacg ttgatcagca gcctgccaga 1291921 ggaacaaagc aaattctcga tgaaaaaggt gcagaagggc ttgcaaattg ggttaaggag 1291981 cagaaatctg tccttttaac tgatacgaca ttcagggatg cccaccaatc gttattggca 1292041 actagaatca gatcgcatga tttgaaaaaa atcgcaaatc cgacggctgc gttatggcct 1292101 gaactattca gtatggaaat gtggggaggc gcgaccttcg atgtagccta ccgattcctg 1292161 aaagaagatc cgtggaaacg tttggaagat cttcgcaaag aagtgccgaa taccttattc 1292221 cagatgttgc ttcgctcatc aaatgcggtc ggctatacga attatccgga caatgtgatt 1292281 aaagaatttg tgaagcaatc agctcaatcc ggtattgatg tgtttcgtat tttcgacagc 1292341 ttaaactggg taaaagggat gacgttagcc attgatgctg ttagggatac cggcaaagtg 1292401 gcagaagctg cgatttgtta tacgggagat atccttgaca agaaccggac gaagtacgac 1292461 cttgcatatt atacatcgat ggcgaaggag cttgaggcgg ccggagccca tattctcggg 1292521 attaaagata tggcagggct gttaaaaccg caggctgcat atgagctcgt ttctgcgttg 1292581 aaagaaacga tcgacattcc ggttcacctt catacgcatg atacgagcgg aaacggtatt 1292641 tatatgtatg cgaaagctgt tgaagccggc gttgatatca tagacgtggc ggtcagctca 1292701 atggcgggat taacgtcaca gcctagcgcg agcggatttt atcatgcgat ggaaggcaac 1292761 gaccgccgtc cggaaatgaa tgtccaaggc gttgaattgc tgtcccaata ttgggagtcg 1292821 gtgcgtaaat attatagtga atttgaaagc ggaatgaagt ctccgcatac tgaaatttat 1292881 gaacacgaaa tgccaggggg ccaatacagc aacctgcagc agcaagccaa gggagtaggc 1292941 cttggcgacc gctggaacga agtcaaggaa atgtacagac gcgtgaacga tatgttcggt 1293001 gacatcgtca aggtaacgcc ttcctcaaaa gtagtcggag atatggcact ctacatggtg 1293061 caaaacaatc tgactgaaaa agacgtttac gaaaaaggtg aatctttaga tttccctgat 1293121 tctgtcgtgg agctttttaa aggaaatatc ggccagcctc atggcggatt cccagaaaaa 1293181 ctgcaaaagc tgatcttaaa agggcaggag ccgattacag tcagaccggg cgaactgctt 1293241 gagccggtgt catttgaagc gatcaaacag gaatttaaag agcagcataa cttggaaatt 1293301 tcagatcagg atgctgtggc atatgccctt tatcctaaag tcttcactga ttatgtgaaa 1293361 acgacagaaa gctatggaga catctcggta ttagatacac cgacattctt ctacggtatg 1293421 acattaggtg aagagataga agttgaaatt gagcgcggca aaacgctgat cgttaagctg 1293481 atttcaatcg gtgagcctca gcctgatgcc acccgcgtcg tttatttcga actcaacggg 1293541 cagccgcgtg aagtagtcat taaagatgaa agcattaagt cttccgttca ggaaaggctg 1293601 aaagcagacc ggacaaatcc aagccacatc gcagcttcca tgcctggaac agttattaag 1293661 gtattggctg aagcaggcac aaaagtcaat aaaggtgatc atttgatgat taatgaagcg 1293721 atgaaaatgg aaacaacggt tcaggcgcct ttctcaggaa caatcaagca ggttcatgtg 1293781 aaaaatggtg agccgatcca aacgggagat ctgctccttg aaattgaaaa agcataaaaa 1293841 acaaagagtg tatatcaatg atatacactc ttgtttttta tatagaaaat gtggagtgaa 1293901 acagatggtt agaagagata taaggggact tcagagatta tagagtactg tcacaagccc 1293961 aaaataaaaa gaggcttata cagccaatat tttagatgct ttgtagtatg ccgtgcatat 1294021 ttctttaagc actatctgat ttaaaaggct ttaatactta tgttcgcgag ctatagatcc 1294081 atatgaaatt tctataatca cgatgagaaa ggggacagac cgaagtgagc cgctcactga 1294141 tcatcaagtt cggcgaaggc tggcgattga aacgcataaa gcgccaaaaa acaagacata 1294201 aaaaagacca aagccgccta aggctttggt cttgagtcct tatgattgcc tggattcata 1294261 acggaaacga gcaatcaata ataagaagta gcatagaacg ccaaacagac aggcaataaa 1294321 gaacgagtgg gcaagtgcaa agcccagagc cagttcagag tatacgatca taataccgga 1294381 cagtgcctgt aatgtaatga aaataagaca tgagatccat ccccaaaaga tctgtttttg 1294441 atctttatag gaagtaatag catgaacagc ggcaacaata atccatacaa ataaaagtaa 1294501 ggctgctgct ctgtggccca tttgcaccca ttcatggaat tgggtcggaa gtccattgtt 1294561 cagcgggctg cacagcggca cattaggaca tgccagactt gattcagtgt gtcttacata 1294621 tgcgcctgta tacacaacga tataggaata tattaaaatt cctatcatgt gaaattgcat 1294681 ctttttgccg atttgaagcg gcttaaccag tgttctgact gatttatcag cttcaaatat 1294741 gagcaatgtt aaaataagca ctgaagcaaa agaaattaat gagatgccga agtgaagcgc 1294801 cataatcagc gcgttcgaac cgaatacgac agccaatgcg ccaagcaatg cctgaagaaa 1294861 taaaaagata attgacatga tcgcgagaaa cgttgtttca cgaaaaatcg gcgtgatttt 1294921 tctccatgac caaaacgcaa ggcttagcac aaggataata gagattccgc ttgcgaatcg 1294981 gtggctccat tcaataattg aagccggatt cagttcaggg aaaaaacggc cgtgacacag 1295041 cggccactgt ctgccgcatc cttggccgga acctgttttt gtaacgaggg cacccccgat 1295101 taaaacaatt agcatgacaa atgtcgtcag aacaccgaga gcttttaatg ctttattcat 1295161 acaatattca ccttcttaac atactgctgc aattttatat acgttccaag tgtaagcgaa 1295221 tatgtgtttt gtggcaattc ccagagcctt ttgttcacaa aaatataata gaatgacggc 1295281 ttctggaaaa tgtacacttg attattcatg ccgggtctga tagaaataag gtaaacgcaa 1295341 tgccgatttg gagattgcct tcatctttgg taaaattcat aaaaagttca caaataaatt 1295401 cctgtttgtc gtttaatatt taataggatg tttttttaca agatgttatc ttgtatgata 1295461 gagttgcagg ttattttatt ctcctgcgtt aggtttgtaa gggaggttta cgttatggct 1295521 aactccagaa tcttaaatga tacagctata gacggacaaa ttgaagaaac aacggcatgg 1295581 aaagattttc tgtcccttat taaaataggg atcgtcaatt ctaacctcat cacgactttc 1295641 actggaatgt ggcttgcact gcatatatcc ggtttaagtt ttttaggcaa tataaacacc 1295701 gttcttctta cgttaatcgg gtcttcactg attattgcgg gctcctgcgc gatcaataac 1295761 tggtatgacc gggacattga ccatcttatg gagcgtacga aagtaagacc gacggttacg 1295821 ggtaaaattc agccgagtca ggcgttatgg tctggaattt tgctggttgc tttaggattg 1295881 atcatgctgc tgatgacaac tgtcatggct gctgttatcg gttttatcgg agtctttacg 1295941 tatgttgtat tgtacacaat gtggacgaaa cgccgctata cgattaacac agtagtagga 1296001 agcgtttccg gtgcagtgcc gccgcttatt ggatggacgg cagtggaagg gaatatcggt 1296061 gtcgtagcat gggtgttatt catgatttta tttatttggc agattcctca cttcttagca 1296121 ttggctatta agaaaactga ggattacaga gctgcaaata ttccgatgct tcctgtcgta 1296181 tacggatttg aagtgacaaa aagacaaatt attgtgtggg ttgcgtgcct gatgccgctt 1296241 ccgtttttcc ttggtagcct gggtcttccg attgtcattc tcggcttgct gttaaatatc 1296301 ggctggctga ttcttggctt aatgggattc cgctccaaga atatcatgaa gtgggcaacg 1296361 cagatgttcg tttactcgct taactacatg acaatctatt tcgttgccat ggttgtcttg 1296421 acgcttttct aaaaaataga tatgatgctt gttttatcgc ttcaaaataa acgatgacaa 1296481 ctagtaaatg ccgccttgac ctcttgttta atcaggcggc tttactttta tacatagatg 1296541 gcattttgag taaaaaaact cataatttaa gagaagagga aatgtaagtg ctttattggt 1296601 gataggttgg atggcgatag atttcgatcc gctttccgcc tttgtattga ccagaaaagg 1296661 ggttgggtga aatggtaaag cattggcgtc ttattttatt attagcctta gtgccgcttc 1296721 tattaagcgg atgtggaaaa ccttttttat ccacgctcaa gcctgctggc gaggtggctg 1296781 ataaacagta tgacctgaca gtgctcagca cattgattat ggtggttgtt gttgcagtag 1296841 tatctgttat cttcttttat gtgattgtga gattcagaag atcacgggtc ggtgagaaca 1296901 cgataccgaa acaggtagag gggaataaat ttttagaaat cacatggacc gtgatcccga 1296961 ttttgctgct cattattctt gtgattcctg ttgtattata tacgctggag ctagcggaca 1297021 catcaccaat ggataaaaaa ggccgcaaag ctgaggatgc tcttgtagtc aatgttaggg 1297081 caaatttata ctggtgggag tttgagtacc ctgattacgg cattatcaca agccaggagc 1297141 tgattgtacc gacagatcag cgtgtatatt ttaatttaaa agcctctgat gtaaaacatt 1297201 ccttctggat tccttcagtt ggaggaaaac ttgatacgaa tacggataat gaaaataagt 1297261 tcttcctgac atttgattca aaacgaagca aagaggcagg agatatgttt tttgggaagt 1297321 gtgcagagct ttgcggccct tcacatgcgc tgatggattt taaggtgaag acgatgtctg 1297381 caaaagaatt tcagggctgg acaaaagaaa tgaagaacta taagtctaca gcagagagcg 1297441 atttggctaa gcagggtgaa gaactgttta aagagaaaaa ctgcctgagc tgccatgcgg 1297501 tagagccgaa tgataagcgt gcagaagccg ctagaacggc acctaacttg gcgaccttcg 1297561 gtgaaaggac aaaagtggca ggggtgaaag aggccaacaa agaaaatgtg aaggcttggc 1297621 tgaaggaccc tgacagcata aagccgggga acaaaatgac aggcacatat ccaaagctct 1297681 cagacagcga aacaaatgcg ctttatgaat acttaaaagg cttaaaagcg gaaagcaagt 1297741 agggaagaaa gggagatatt gggggaggtc acatatgttg aatgcgctta cagaaaagcg 1297801 gacgcgcgga tctatgcttt gggattattt gacgacggtg gaccataaaa aaatcgcaat 1297861 tctttattta gtggcagggg gattcttctt tcttgtcggg ggaattgaag cgatgtttat 1297921 cagaattcag cttgcaaagc cggaaaatgc gtttctcagt gctcaagcgt acaatgaagt 1297981 aatgactatg cacggaacga cgatgatctt tctggctgcg atgccgctct tatttgcctt 1298041 gatgaatgcg gttgtgcctt tgcagatcgg ggctcgggac gtttcgtttc catttttaaa 1298101 cgcgcttggt ttttggctct tctttttcgg gggcattttc ttaaatctaa gctggttttt 1298161 gggcggagcg ccagatgcgg gctggacatc atatgcctca ctttcgcttc attctaaagg 1298221 gcacggcata gactttttcg tcctcggact ccaaatatcg gggctcggga cgctgatagc 1298281 cgggattaac tttttggcca cgattatcaa catgagggct ccgggcatga cgtatatgag 1298341 gctgcctttg tttacatgga cgacatttgt ggcctcggca ttgattttgt tcgcgtttcc 1298401 gccgcttacg gttggattgg ctctcatgat gctggatcgg ctgttcggaa ccaatttctt 1298461 taatccggag cttggcggaa atacggtcat ttgggaacat ttattttgga tcttcggcca 1298521 cccggaggtt tatatcctaa ttttgcctgc attcggtatt ttttctgagg tcatccctgt 1298581 gttcgccaga aagcgtttgt ttggctattc ttcaatggtt tttgcaatcg tgctcattgg 1298641 ctttctgggc tttatggttt gggtgcacca catgttcacg actggtctcg gcccgattgc 1298701 aaatgcgatt tttgcggttg caacaatggc tatcgcgatt ccgaccggga ttaagatttt 1298761 taactggctg ttgacgattt ggggaggaaa tgtgaagtat acaaccgcta tgctgtatgc 1298821 tgtctcattt attccatcct ttgtgctcgg cggtgtgacg ggagtcatgc tggcagctgc 1298881 tgcggctgat tatcagtttc atgatacgta ttttgtggtt gcgcacttcc actacgtcat 1298941 tattggcggc gttgtattcg gccttttagc cggtgttcat ttctggtggc cgaaaatgtt 1299001 cggtaaaatt ctgcatgaaa cgatggggaa aatttcattt gtattgtttt ttatcggctt 1299061 tcacctcacg tttttcattc agcattttgt cggcttaatg gggatgccgc gccgggttta 1299121 tacgtttttg ccaggacagg gtctggaaac cggcaacttg atcagtacaa tcggggcgtt 1299181 ttttatggcg gcagctgtta ttcttctgct ggtcaatgtc atatggacat cggtaaaagg 1299241 tgaatatgta ggtgctgatc catggcatga cggacgtacg ctggaatgga ccgtttcttc 1299301 accgccgccg gagtataact ttaaacagct tccttttgtc agaggacttg atccgctttg 1299361 gatcgagaag caggcagggc acaaatcaat gacgccggcg gaaccggttg atgatattca 1299421 tatgccaaac ggctcaatcc tgccgctcat catttccttc ggcctttttg tcgcagcgtt 1299481 cgggctgctg tacagaagtg attacgcttg gggcctgccg gtgatcttta tcgggctcgg 1299541 catcacattt attacgatgc tgcttcgttc agtaattgat gatcacggct atcatattca 1299601 taaagaggaa ctgccgaacg atgataaagg ggtgaaggca taatgcaagt tcaagaaaaa 1299661 ttcaccgcag aaacctttcc agcttctcct gaaaaagtaa ccctggaagg gaaaaataaa 1299721 tttttaggct tttggctttt tcttggcgga gagactgttc tgtttgcgtc tctcttcgcc 1299781 acgtttcttg cgcttcggaa ttcaaatgcc ggtgatccgc ctacgacgga aatgttcgat 1299841 gtgacacttg tattcattgc cacaatgctt ctattaacga gcagtttaac gagtgtgtac 1299901 gcgatgtacc acatgaagaa cttttccttc ggcaagatgc agctttggct gggaattacg 1299961 attttattgg gggcgggctt tttaggactg gaaatctatg agttcaagca ttacacccat 1300021 gaatttggct ttaccatcac aagctctgcc cttggttctg cgttttacac gcttgtcggt 1300081 acacacggcg cccacgtggc atttgggctt atgtggatca gcacgcttat gatccgcaat 1300141 gccaagagag ggctgaatct gtatacggcg cctaagtttt acgttgccag cctttattgg 1300201 cactttattg atgtcgtgtg ggtcttcatc tttaccgttg tatatttaat ggggatggtg 1300261 ggataaacat ggtcgataaa aaaagcagag ggcatatcaa tagcgacctt gaatttaaga 1300321 aaaaaaagca tgcccgggag atgaaatatc aagtcctgtc ttttggttta atgatcggtc 1300381 ttacgattgt tgcatttctg actgtggcca cggacggtgt cggcagctgg tttacgattc 1300441 ctttcattat tttgctagct gcaattcaag tcatttttca gctgtattat ttcatgcata 1300501 tgaatcagaa agggcatgag gcgccggcac tgtttttgta ttcaggggtg tttgtcgcgt 1300561 ttatcactgt gcttgcgttt gtgacaatta tatggtggta atttgaacag ccgccggagg 1300621 tgaagaaatg aatcagttgg agatatttgg gtttcgcgcg atgtggagcc cttatctttt 1300681 ttgtatcctg ttaggcatta cggcgcttta tctctatttt tacaggcgaa tgtcttcaaa 1300741 gccgaatcga ataactggta aagagatggt gtgctttctg tcggcgatgc tgtttttata 1300801 tgcagccgag ggaagcccgg ttgatctgct cggacatatt atgttcagtg cgcatatggt 1300861 gcagatggcc gtcctgtatt tggttgtccc gccgctgtta atcgcgggga ttcctgcatg 1300921 gctctgggaa aaaatcattt tcaggccttc aatcaaaccg gttttttcct tttttacgac 1300981 gcctttaatt gctttgcttt tgtttaacgg cattttttct ttatatcatg taccgcttat 1301041 atttgatact gtcaaaacag atccgtttta ccatacatta atcacttggc ttatctttgt 1301101 gcttgcgttc ttcatgtggt ggccgcttgt tcataaggtt gagcgtctac ggcagctcag 1301161 cggcttgatg aagctgggtt atattatggc ggacggtatg ctgctcacac ctgcttgcgc 1301221 cttgatcatg ttcagcggtg caccgttata cgccacctat acagatccgg ctttatgggc 1301281 tgaggcaatg aggctttgcg tgccagcgga tatgatgggg caggtcccat taacagggcc 1301341 agagatgttg aatacactgc ctttgttaga ggatcagcag ctcggagcag tcatgatgaa 1301401 aatcattcag gaaattgtgt acggtacttt tttggccgtt atttttttcc aatgggtgaa 1301461 gaaagaaagg gaaaaggacg ggcaggagga gccgccgtat attcagcaga cgatatcata 1301521 aaaggtacag cgaaatatgc tgtacctttt cgttacattt gaactgtttt taacatgttg 1301581 gctatgtcct gaatcagtgc cttgcttttt gtcacaacct gtacgggaaa ctcttccgtt 1301641 tctccatatt ctactccatg agggtagtaa tgctttccta ggagagggga cattaattga 1301701 atcacggcgc gcccgcttcc gacatcgcct tctgccgcaa taccttgtat ccgcaggtaa 1301761 aacgtaccct caatcgtcga aaacttcttg tcataggtga ctctctcgta atcccattga 1301821 cccgctctga taagaccttt gctttccatt aagtcgtcta gccagctgag ctcagcctta 1301881 accccttcaa gtccgctttc agtaaacttc aacactgacc cctccttata aaaattacct 1301941 ttcctgacaa tcatagtatg aaagcgttaa actttcaatg aatcttcttc ttttgaaagt 1302001 atgcaaaaat taaattttga cgacaatagc actagactaa aggaggttaa acggatgaca 1302061 aaaataaaag atctgatgac agccgacttg caatattgca cggtattaga taatgtatat 1302121 gaagctgcag taaagatgaa ggacgcaaat gtaggagcga taccggtagt tgatgaggac 1302181 ggggaaacat tggtcggcat cgtaaccgac cgcgatctcg tattaagagg aatcgccatc 1302241 aaaaaaccga actcgcaaaa aatcactgac gcgatgactg aaaaacctgt cagtgtggag 1302301 gaagatgctt cagtcgatga ggttcttcat ttgatggcat cgcatcagct cagaaggata 1302361 ccagttacaa aaaataaaaa actgactgga attgtcacgc ttggtgatct ttctttatct 1302421 gagcaaacga atgaacgtgc cggcagcgcc ttatcggata tttccgaagg ggataataga 1302481 gaagaaggct tttttcatta acacataaat ctttgacatg ttaaataggc tgtattgtaa 1302541 tgggatgtaa acaagagatt gtgaatcgcc acgggggtga tagattgaaa aatatattga 1302601 gagcaatggt tatccttttg attatctgcg gaacctatgt tctgtttatt caatatggat 1302661 ctgttcctga aaagaaatca aatgacagcg agcctcaggt gtcgaatgag gaagcgcaaa 1302721 gcggcaaacg aatacatatg ccgacttcag ggttattgtc cttcatgggc aagcacgccg 1302781 atgaagtaac gaaaaagctt ggggaacctg aacgtattga cccttcggct tatgattacg 1302841 attggtgggt atacaatcaa ggtaaggatc aatatatcca aatcggggta ttaaacaata 1302901 aagtggtcac attattcgcg tcgggtaatg atattaacgc caagcctttc aaaattggag 1302961 aatcaactgg cgaagtattc aagaccaccc aggtggcacc atttgtgaat gtagagtata 1303021 aaggaaattc ctatcggttt gaattttctg aagaagatat caatacaaga ccgactgtaa 1303081 aggtaggaaa gatgtatgtc cagctgtata tggacaaatt tgaggggaag ctatccagca 1303141 tcagggcgtt tgatgcgcag acctttgtaa agcaaagacc ttatgaggta gtgtaccgcg 1303201 gggaattaat taaaccgaaa gccgtttcag atgagaaatg gaaaaagatc caaacaacga 1303261 gcgaaaagca aatccttgat ttgacgaatg tcatacgcgt taaacatgga cttgcgaagc 1303321 ttgagtggga tcagccaacg gcggaagtgg catttgggca tagtgaggat atgaaggaaa 1303381 ataattattt ctcccatgtc tctaaaaaat acggctcgct gaaagaccgc ttagaagaag 1303441 ggcatgttga ttttcagcaa gcgggagaaa atatcgcata caattatgtg gacggtccgg 1303501 ctgctgtaga aggctggctg aatagcgaag gccatcgaaa agcgcttctg aattcagatt 1303561 atacgcatct tggtgtcgga gtagaccgga aatattacac ccaaaacttt attaagcgat 1303621 ggtaatgaaa gccgcggacg aatggttccc ggctttttct atttccatac aagctggtct 1303681 gaatgaatgt gctgatagct tacagataag gccgtttccc atcccttcag tcaggctttt 1303741 tcaccagtgt atagggatat cgctaaaaat tcatttggga atgaatatag gcgaacacaa 1303801 tgcccgacaa aacgatacat tgtagtaggt aacgattttc ggagggggtg aggattgtgg 1303861 cgaatcaaca tgccaatcat tcaatcaatg actttaaaca attcgtcaaa aagcatccca 1303921 agctgataaa agaagtgcgc aaagaacaaa gaagctggca ggacgtatat gaaaattggg 1303981 tcctcttcgg ggagagcgac ccgatttggg atccatatcg ggaaccggaa gaagcttctg 1304041 aagctgtgcc tgaaacaccg caaaaaaatg attttgtctc gaaaatggtg acagcggtga 1304101 aaaagatgga tgtcaatcaa atgaacgaac aaatcaataa aatgagccag tcgatctcat 1304161 cgttgcaaag ccttcttaat acattttccg gaagcggaca gaagcattct cagccaggct 1304221 ctggacagca tcctttttct tttcgaaagg attaaaaaag gggagctcat atgcgcaaag 1304281 aggttcagga atatatttta gcaaacgaag aacggaaacg attcatcaga gaacagccga 1304341 tatggtaccg caggctttca agaaaaccgg atgatctgtc ctcctttcag cttgaaatga 1304401 tgaattttta tgaaaaaacc attccgcatc gggtgaatca gtttacgaac gggattcaaa 1304461 tggcgcaaat gatgatgcaa atgtttcaag cgatgcggac aaaagattaa aaggccccga 1304521 agaagggtct tttttcatgc ggtcataagg ttttgttggc ggctgcggtt aagcattttc 1304581 caattggctg gtttcatggt aaactaacaa ctggaggtgc atgttatgta tgcgacgatg 1304641 gaatccgtgc ggcttcaaag tgaagctcag cagcttgccg agatgattct gcagtcggag 1304701 acggctgaga actaccgcaa ttgttacaag cgtctccagg aagatgaaga ggcaggtcgg 1304761 attattcgtt cttttatcaa aataaaagag cagtatgagg atgtacagcg ttttggcaaa 1304821 tatcatcctg actatagaga aatatcccgg aaaatgaggg agatcaaacg tgagctggac 1304881 ctgaacgata aggtggctga cttcaagaga gctgaaaatg agctccagtc cattcttgat 1304941 gaggtcagcg ttgagattgg gacagctgtt tcggagcatg tgaaagttcc gactgggaac 1305001 ccttattttg acggtttgtc ttcatgcgga ggcggctgcg gttcaggcgg aagctgcgga 1305061 tgtaaagtgt cctgacgaga ctggccgtct cgtcttttac atataagaga aaacaggcag 1305121 gtgattgtat tggagaatag gcgccagggc atggttgtgt atctgcactc cctaaagcag 1305181 agcaaaatgc tgaggaagtt cgggaatgtg cactatgtat caaaacgatt aaaatatgtc 1305241 gtactgtact gtgatatgga ccaaattgaa aaaacaatgg acaagattgc gtcttactca 1305301 tttgtgaaaa aagtggagcc ttcttataaa ccgtttttaa aattggaatt cgagtcaaag 1305361 cttgataagg caaaagaata cgattataaa atcggcatat agctataaaa aaatccccgc 1305421 aggcatctgc ggggtccttc tattccttaa tatgttaagg agaaggcaaa gggagaggag 1305481 aaaccggagg aagaacttat ggggaaacgt aagtcttctc cgcggttggc aacaacatcc 1305541 tctagatgct gttgcttata gtatggacaa ggatcatgct gcctatacac ctgtttatca 1305601 agattagcgt tcattgtttg gaagaatgct ttatgttaag ataggattga tttttttcta 1305661 tgtacatagc ggcgtccggc cgaataaaga aacaaaatag cttttagaaa aagtggtgtg 1305721 gaacatgaga gtaatttctg gatcaaaaaa aggccgttca ctaaaggctg tagccggaac 1305781 atcaacaaga ccgacaaccg acaaagtgaa ggaatccatt ttcaatatga tcggccctta 1305841 ttttgacggg ggcaggggac ttgacttatt cgcagggagc ggaggtcttg gaatcgaagc 1305901 gctttcacgc gggtttgagc attgtatatt cgttgaccgt gattttaaag cgattcaaac 1305961 ggtaaaatct aatttgaaaa cgctggagct tacaaaacat gcacaggtat accgcaatga 1306021 tgcggaacgt gctttgcacg ctgctgctaa aagagaaacc ggctttcgcg gaatttttct 1306081 cgatccgccg tataaggaac aaaagctgaa agcactttta actttgattg acgaatatca 1306141 aatgctggaa gaagacggct ttatcgtcgc tgagcatgac agagaggtcg agcttcccga 1306201 aaccgtagga gatcttgtga tgacaagaaa agaaacctat gggttaacag gtgtagcgat 1306261 ttataaaaag agggggtagt gaggtggcga gtatagctgt ctgtcccggc agttttgatc 1306321 ctgtgaccta cgggcatctg gacatcatca aacgcggggc gcatattttt gaacaagtgt 1306381 atgtatgtgt gctgaataat tcttcaaaaa agcctttgtt cagtgtggaa gaacggtgtg 1306441 agcttctgag agaagtcaca aaagacattc cgaacataac agttgaaaca tcgcaaggcc 1306501 tgttaattga ttatgcaaaa agaaaaaatg cgaaagcgat tttaagaggc ttgagagctg 1306561 tatctgattt tgaatacgag atgcagggga catcagtaaa ccgggtgctt gatgaatcta 1306621 ttgagacgtt ttttatgatg acaaacaatc aatattcgtt tctaagttca agcatcgtaa 1306681 aagaagtggc aagatacaac ggctcggtat cagagtttgt accgccggaa gtagagttgg 1306741 cgcttcagca aaaattcaga caaggatgag ggttttgact catccttttt ttgttccgtt 1306801 tgtcagtctg taagaaaaaa tgataatgta cgtaaacagc gcgcatagtg tgacagcagg 1306861 tccgatctgc acaagcagat tccagccgtt tataaaggca gttgacatgt cactgctgtt 1306921 aagagattta aatacatact gatacggatc atgccatgct gtgtaaagag gtttccataa 1306981 aagcatgacg aagacagcgg cataaacgcc ctgcagcaaa cgtgcgataa agaatggttt 1307041 aaatctaatg tcggtttccg ataaaatacc tgccacctga gcttgtacgg aaaagccgct 1307101 aaacccaaga ataaagctga cgataatggc tttttgcaga agagaaacat ctgtctcgct 1307161 gacaagcttg ctgcctaatg taatttcaaa catccctgat aaaagcggaa tgtccaattg 1307221 agtcggaagc tgaaacaaag tcagtgctcc ttttgtgaaa acagacaaaa catcagtcag 1307281 ctggaccact gacaacagcc gattgaagac agaaaataaa ataataaagc cgcctaccat 1307341 aagaagcgtt tgaacagaag acgtcacggc gtcgcctaaa attttaccta agggccgttt 1307401 ttctgcaagt ctggcggtat gaagagcgtg taaagcatct ttgactgaag ggaaaggtat 1307461 cgttttcttt cttctgagat gctgctcttc cttgcggcca taggagcgca ttgttaaacc 1307521 gacggcaaga ttccccaaat agtgtgcaga agctaataaa atgcctagtg atgcgttttg 1307581 aaagaaaccg acggcaacag cgccgaaaat aaagagcggg tttgaagaat tggtaaacga 1307641 cgcgagccgt tctgcctcta ctcttgaaat ctgattttcc tgccgcagac gggcagtgag 1307701 ttttgcgccc gctgggtttc ctgatgccat tcccatagca agaacgaagc cgccgacacc 1307761 cggcacgcga aagatcggcc gcataaaagg ctcaagcaaa acaccgacaa accgcacaat 1307821 gccaaagccg attaagagtt cggacagaat aaaaaatggc agcaatgacg gaaacacaac 1307881 ctcccaccac atagacagcc cggttttaga ggcttcgaat gaggcctgtg gatgtgagat 1307941 gacagtcgct gttaaaaaaa gaaaaaacga ggcaatcaaa agtgtattaa tcttcgacaa 1308001 gttcattctt acctccccga tgctaaaaat gcccaatgac atgtatatca tgataaaata 1308061 atgtatgatg taaaacggcc aagcagtacc tgtcctcttg attctttgta ctaatatacg 1308121 agcatagggg ttcagtttag accatagaat tcggtataca gggaattcag gcaggaggtt 1308181 aacgctttgg ccaaacctaa aatcgggtta gcgttaggat cgggaggggc cagagggctt 1308241 gctcatctcg gtgtgctttc cagtttacat aagcaccaaa ttgaagtgga tatgattgca 1308301 ggaagcagca tgggcgcttt ggtgggcagt ttttacgccg ccggacatga cgtggcaacg 1308361 atgaaaaaag tagccaaagc ctttaaacga aggctttatg ctgattatac ggtgccgaaa 1308421 ctcggttttt taaaaggtga ccgcgtcaga cagcttgtgc atgcttatac attcggaaaa 1308481 ccgattgaag agctccaaat cccgctgggc attgttgcgt gtgatctaca gacgggagaa 1308541 aagattgtgt tccgaaaagg atcagtgtca gatgcagtga gggccagcat cagcatcccg 1308601 ggtatcttta ttccgcagcg gctggacgga cgccttcttg tagacggcgc ggtcgtcgat 1308661 cgaattccgg tttctgttgt gaaagacatg ggagctgata ttatcatcgc ttcggatgtt 1308721 tccagggttc gaaaaactga aacagcagtg catatttttg atgtgattat gcaaagtatg 1308781 gatatactgc aaaatgaatt agtgcggcat caaacaattg ccgcagatat catgattcgc 1308841 ccttcccttg aaacatacag ctcaagctcg tttgccaata ttgaagaaat gatatcggca 1308901 ggcgaagagg cgacaaaccg aatgatcagc aagataagaa aagaaataga gaattgggag 1308961 ggctcataat ttgctacgta aaaaacattt tagctggatg ctcgtcatcc tcatactgat 1309021 cgccgtttta tcatttataa aacttccata ctatattaca aaaccgggag aagcgacaga 1309081 gcttgcttca ttgataaaag tggagggagg ctacccggaa aaaggaagtc tgtccttaat 1309141 gactgttaaa gtgggaccgg ctaatccatt tacatatgtg tgggcaaaga tgcaccctta 1309201 ttatgaaatt gttcctgatg agagcattaa ggaggaaggc gaatcagata aggagtatat 1309261 gaaaagacag ctccaaatga tgaaaagctc gcaagaaaat gcggttatag ccgcctatca 1309321 aaaggcagga aaaaaagtca gctattcctt taacggcata tacgcaagct cagttgtaga 1309381 aaacatgccg gcaaaaggga aaatagaagt cggtgataaa atcatcagcg cagacggcaa 1309441 aaactatcag tctgctgaaa agctgattga ttatatcagc agcaaaaaag cgggagataa 1309501 agtcacgtta aagatcgaaa gagaagaaaa agaaaagcgt gtcaccctta cgttaaaaca 1309561 atttcctgat gagccggatc gggcaggaat cggagtttcg ctttatacag acagaaacgt 1309621 gaaggtagag cctgatattg attttgaaat cgaaaatatt ggcggcccgt cagcagggtt 1309681 aatgatgtcc cttgaaatct ataatcagct gacaaaacca gacgaaacaa aaggctacga 1309741 tattgcggga acaggtacga ttgatgttga cggaaaagta ggcccgatcg gcggcattga 1309801 tcaaaaagtc gtcgccgcag acaaagccgg aaaagacatt ttcttcgcgc caaatcaaaa 1309861 cggcgccagc aattccgatt ataagaacgc agtaaaaaca gcaaaagata ttgattcaaa 1309921 tatgaagatt gtgcctgttg ataccatgca ggatgcgatt gattatttga ataagctgaa 1309981 agcgaaaagc acctgattct caggtgcttt ttctatacat ttaaaaagtg ttgttcatct 1310041 tcgtcatatc gaatcggtgc atgtccgtat tcctgtaggt caaactcagt tctcagcggc 1310101 tcttctatcg gcaggctgta aatcctgctt gcttttacgt ccagatcgag agctggatgg 1310161 gagaaagagg acagtttgct gacaagcgga acagacagtg cttttttctt ttcggataaa 1310221 taagcctgtc cttttttcgt catgccgaga agcctgatat acggcgcctt atcgttgtca 1310281 agcagctttt gcatatcctg tttttttgtt ctggttaaaa tgtgtgtatt catccgctgg 1310341 agccttgtcc acgtatagcg ttttgttttc agcagttcca taaattcctg ataggagctg 1310401 gattttctga tcgaacgaat aattctgtgc tctaaacctt cctccacctc gtatacttgc 1310461 tgtaattccc gtgccgttac agttgaaagg ctgtatttta agtaagaaaa gtagctttca 1310521 ggtgtatgcc acaatccgaa agatttgcgg taagctgcta attcacgtgc agatgcagca 1310581 gggagaaaac gaaggcaggc ttcgagattc tggccaatca tcgcttttct aatgcttgtg 1310641 gcacttgcta tatggttttc gccttcaggg agatcggcat catgatagtc cgaagagatt 1310701 cgtgccgtag tataaggttt cataggatat cccccggtta gaatcgaggt cacatactgg 1310761 tatcccaaaa tgttatttgg ttttgacaag tcaagtgcac tttcagtatg caaaatggag 1310821 ctgaaggcga tagccgccgc tgctgggtaa ctggccccct ttttaagttc ttctttaatt 1310881 cggtcattca atatatgttt atgctcatca ataagctgtg ctgtttctaa aaaaggcttg 1310941 atatccccat tttcactccc gaaaaacagc gcctcacatt caagttcgtt caggatggaa 1311001 acactgccgc gtgcaaaaat gtctgctttt tgcacggcat aaagataagg cagctcaatg 1311061 acaagatcaa ctccgctttg cagcgccatt tttgttcggg cccattttga tacaacagcg 1311121 ggttccccgc gctgtaaaaa atgtccgctc atgaccgcga cagccgtgtc acatccggtt 1311181 tgcagctttg ctgtttgggc atgataaagg tgaccgttat gaaagggatt atattcaacc 1311241 accaatccga cagctttcat attttttccg cctttcttgc tatgtttaaa aacgtatggt 1311301 acatttgcaa atgaaaactc ttacgcctta tttttgtttt aagtgtatgc atagcatatt 1311361 ccgctgtcaa cgatacttca atggcagcat tatgctgtaa agaaaaaata ttgacaaaaa 1311421 caatcttaaa agctataatc atgtttgttg ctttcctgag gtgatacaaa tgaaatggac 1311481 gatttatcag ctgcatcaaa tgccaaaaca aagttttgag tttgatgaaa cagttgagtt 1311541 aaatgagctg acaaagctga attctgacat tcgccgcatt tctcccgttc gggtgaaggg 1311601 cagagcggat atcaaatcca aacaggtttc gtttgatttt acaatttcag gcgaaatgct 1311661 tttgccatgc tcaagaacac tcgttgatgt tccgtatcca tttgaaattt caacaaaaga 1311721 actgtttata tttcatcaca cggatgatat agaagatgat gacgttcaca ttgttgagga 1311781 cgatactatc gacataactc cgatcgtgaa agaagaaatt cttttagaaa tccctatgca 1311841 aatcttttgt gaatctgaac aagaaaaagg agctgctcct caagaaggaa aggattggca 1311901 agtcatttcg gaagaagaca agaagaatca agttgatccg agacttgcag cccttgaaaa 1311961 gctcttaaaa caagatgatg aatcttaact ctttaaggag gtgggaataa tggctgtacc 1312021 ttttagaaga acttctaaaa tgaagaaaag attgcgccgt acacatttca aacttaatgt 1312081 acctggtatg acagaatgtc cgtcatgcgg agagatgaag ttgtctcacc gtgtatgcaa 1312141 agcatgcgga tcatacaacg gcaaagacat aaatgtaaaa agtaactaat gagaaaagcg 1312201 cagggtgaaa gccctgcgct ttttcttttt ctcttcctgt cagcttgcgg aaaatttgtg 1312261 agtgcaaata gtctatctaa tctattaccg gcatatgtat gagataaata agctgacatg 1312321 gagggagatt gaatttgacc attacaagac aagatgcttg gactcaggat gaggatttgc 1312381 tgctggcaga agtggtgctt cgtcatattc gagagggagg aacacagctt tcagcctttg 1312441 aggaggttgg aagggcgctg accagaaccg cggcagcctg tggtttcagg tggaactcgt 1312501 atgtgagaaa acaataccag tcaggtatag agcttgcaaa aaagcaaagg aaagaactga 1312561 gaaagcaaat cggcgttcat tcggtcaata tgccgaattc catgaagcag actgcctcgg 1312621 catcgtcaga aggaaaacga gatttgtcca ttcaggatgt cattcaattt ctcgaacaat 1312681 tcaaagaaac accgtctgca caagaatttc agcttgaaag ggaaaaattg aaggagcaaa 1312741 tccaatcgct gcaaaaagag cttgaggatt tgcggagtga aaatcagaca ttgcggaatc 1312801 agctagagat gacagaagag gattacaagg cactgatcga tatcatggat cgggccagaa 1312861 aaatggttgt ttcgaaggaa gacggaagaa tgaaaaaagc ggctcaagaa acgtaaagaa 1312921 acgcctgaaa tgaaccggcc ctatagtaag aataggccgg ttgttttgat ttctatgcag 1312981 actctcccgg tgtcatttcg cgatccatat caggatgcca gatgagcggg ttttcccctt 1313041 tgtcccgcgc catatcatac ttaacagttt taaagttcat tttgttccaa aattccgctg 1313101 atttcattct cggatttgtc cggatcggca ttttgaatga ttttgcaaat tcaaccaagg 1313161 ctctcccgta tcccctgttc tggtagcccg gaagaacctc aagcttccac agctccaaat 1313221 aatcctggcg gttgtcaaaa tagggattcg atttgccgtt aacttgatac agactcattc 1313281 gtgctacaag tttatcgcca aaataaatcc cgtaaaaagg cgaggtgctg tcattttcaa 1313341 taatattatc ctgaagttct tcaagcattg aaagctcctg aatgccgtat tctttgaatt 1313401 tcttgaattc ttccagcgtt ttatagttga taagcagacg ttctaccttt gtcaaacaaa 1313461 tctccccctt tgttgtttct acatatattg taaacgcttt atttaaaaaa tccaaatatt 1313521 taaactttaa ttttaagcac atgggatctt tgagaagtaa tttcttctta cttctgctat 1313581 gataatacgt aaatgctaaa ttgggtgtga catcatgaaa attggaatta tcggcggagg 1313641 ctccgttggt cttttatgcg cctattattt gtcactttat cacgacgtga ctgttgtgac 1313701 gaggcggcaa gaacaggctg cggccattca gtctgaagga atccggcttt ataaaggcgg 1313761 ggaggaattc agggctgatt gcagtgcgga cacgagtatc aattcggact ttgacctgct 1313821 tgtcgtgaca gtgaagcagc atcagcttca atctgttttt tcgtcgcttg aacgaatcgg 1313881 gaagacgaat atattatttt tgcaaaacgg catggggcat atccacgacc taaaagactg 1313941 gcacgttggc cattccattt atgttggaat cgttgagcac ggagctgtaa gaaaatcgga 1314001 tacagctgtt gatcatacag gcctaggtgc gataaaatgg agcgcgttcg acgatgctga 1314061 accagaccgg ctgaacatct tgtttcagca taaccattcg gattttccga tttattatga 1314121 gacggattgg taccgtctgc tgacgggcaa gctgattgta aatgcgtgta ttaatccttt 1314181 aactgcgtta ttgcaagtga aaaatggaga actgctgaca acgccagctt atctggcttt 1314241 tatgaagctg gtatttcagg aggcatgccg cattttaaaa cttgaaaatg aagaaaaggc 1314301 ttgggagcgg gttcaggccg tttgtgggca aacgaaagag aatcgttcat caatgctggt 1314361 tgacgtcatt ggaggccggc agacggaagc tgacgccatt atcggatact tattgaagga 1314421 agcaagtctt caaggtcttg atgccgtcca cctagagttt ttatatggca gcatcaaagc 1314481 attggagcga aatacaaaca aagtcttttg agctttttcg gtaacatgct atactcattt 1314541 cggatcacta actatttatt ggagaaagga agttctagaa gatgcagcta actgaacttt 1314601 ccatcaaaaa tcagaatgtg tttgtacagc actatataga tggcaaagaa gaaatgtctt 1314661 ctttttttga ttacagtatt catcataagg acatgtggcg cgaaagactg gaagacttat 1314721 cttcccggtt tttcgcaaga gaggaattgg cggcgtactt aacctcttac cataataaat 1314781 tcggttcaag tgcgatgcag tctgctattg agaagctgaa ggacccgtca agtgccgctg 1314841 tagtcggcgg acagcaggca ggacttttaa caggaccgct ttacaccata cataaaatca 1314901 tttcaatcat tgttttagca aagcaacaag aaaaggaact gcaagtgcct gtcataccaa 1314961 tcttctgggt ggctggagaa gaccacgatt tggatgagat taattttgtt cacacatctg 1315021 aagagaatgg gcctgtgaaa aaaaagctgc ctcagtctta ttggaagaaa tcatcagcag 1315081 cgagtacatc gcttgatcag gaaaagtgtg ccgcgtggat agatgatgtt tttgccgctt 1315141 ttgaagaaac agaccatacg aatacacttc tcgacaatgt gaaacgatgt ttaagggaat 1315201 ctgttacgtt tactgacttc tttgaactgc tgatcgcgga tttgttccaa gaagagggct 1315261 tagttttatt aaattctggg gatccgggga ttaaaaagct ggaaacggcc atgttccaaa 1315321 agattcttcg agaaaatgat gaactcgccc gggctgtatc agatcagcag gccttcatgc 1315381 gtcaagcagg ctacaaaccg attatcgagt ccggaaaaga gcaggcgaat ctgttttatg 1315441 aatacgaaga tgagcgtttt ttaattgaaa aagataacgg ccgatttgtc atcaaagagc 1315501 ttgatctagg atggacgagg gatgaacttc atacacatat ggaagaacat ccagagcgtt 1315561 tcagcaacaa tgttgtaacg agaccgttaa tgcaggaatt tctcattccg actttagcat 1315621 ttattgcagg gcctggggaa atcaattatt ggggcgagct caaacaggca tttgcggtga 1315681 tgggcttcaa aatgcctcct gtcatgccaa ggctgaacat tacgatactt gagcggcata 1315741 ttgagaaaaa actggctgaa cggaatatct cattacaaga cgcgattgag cgcggaacgg 1315801 agaatcaaag agagacatac ttcgagcgcc agattccgga agagtttacg gcggtgatgg 1315861 atcaggcgaa aagccaaatt gaagcgattc acaaaacggt ccggcaggag gcgttaaagg 1315921 ttgatcaaag cttggaacct ttacttctga aaaatgccgc ttttattcag gatcagcttc 1315981 aattcttaga gcgcacggtg atgaagcgaa ttgaagaaaa agaaggctac gtcttgaagg 1316041 attatgaaag aattcaaaat agcattaagc cgcttcttgc gccgcaagaa cggatttgga 1316101 atatcatgta ttatttgaac aggtacggtc caaaattctt cacgacattc aagaatctgc 1316161 cattttcttt tcaaaatcaa catcaagttg tcaaactttg aaataaagtt ttaaagaacc 1316221 ctgactagtt cagggttttt ttttatgggt aaacagtgta aaatgaagtt gtggagcgaa 1316281 gtggtgaata gtggtgagtt aaggagagaa agtggggcaa gagatcatgt ttatgggtga 1316341 atatcagcat accatcgatg cgaaaggccg catgatcgta cccgctaaat tcagagaagg 1316401 cctaggtgag caatttgtgc tgactagagg acttgaccaa tgtctcttcg gctaccctat 1316461 gcacgaatgg aaacaaattg aagaaaaact aaaagctctt cctctcacaa agaaagatgc 1316521 ccgcgcgttt acccgtttct tcttttcagg ggcgactgaa tgcgaactgg ataagcaagg 1316581 cagggtaaat atcgcatcat ctctattgaa ttacgccaaa ctggaaaaag aatgtgttgt 1316641 tatcggggtt tctaatcgaa ttgaattgtg gagtaaagta atttgggaac aatacacaga 1316701 agagcaagaa gattcatttg ctgaaattgc tgaaaacatg attgggtttg atatataatg 1316761 attcttcgtg tataacactc taaaaacaat ttcaattcat cctgataaaa ggtgggacca 1316821 acacaatatg tttcaacaca agacagtact tcttcgtgaa accgtagacg gacttaatat 1316881 taaaccagac ggtacatatg tagactgcac actcggcgga gctgggcata gtacatactt 1316941 attgcagcag ttatccgaga aggggcgttt aatcgctttt gaccaagatg atacggcatt 1317001 acagcatgct aaagaagtgt tgtccgatta taaaggacag ctcattctga ttaaaagcaa 1317061 tttcaggtat ttaaaagaat atttgaatga acaaggcgtt acagaagtag acggcatttt 1317121 atttgattta ggggtgtcct ctccgcagct ggatacaccg gagcgcggat tcagttacca 1317181 tcatgacgca ccgttggaca tgaggatgga ccagtcggct acgctttcgg cgaaagaagt 1317241 cgttaatgag tggcgctatg aggatctcgt ccgtattttc tttaaatacg gagaagagaa 1317301 gttcagtaaa cagatcgcca gaaaaattga ggaggcaaga atgaagtctc ctattcaaac 1317361 tacgggccaa ctggtcgatc taataaaaga cgcgattccc gctccagcga gaaggagcgg 1317421 gggacatccc gctaaacgcg tgtttcaggc aatcagaatt gccgtaaacg atgaacttag 1317481 ggtgtttgaa gaagctttgg agcaggcaat tgaggttctg aagccagggg gcagggtatc 1317541 ggtcattacc ttccactcgc tagaagacag aatttgcaaa accactttta aagaaaagtc 1317601 gtcgcttccg gaacttcctc cgggacttcc tgttataccg gaagagtttg aaccggagct 1317661 gaagctcatc acacgaaaac cgattacggc atctcaagaa gagcttgaag agaacaaccg 1317721 ggctcgttct gccaagcttc ggattgctga aaaaagaaaa taacgaaacg cgaacgcaaa 1317781 attaaaagga ggtcatcagc ctatgagcaa tttagcttac caaccagaga aacagcagcg 1317841 gcatgcgatc agtcctgaga aaaaagtgat tgtcaagaaa agggcttcca ttactctcgg 1317901 agaaaaagtg cttcttgtcc tctttgctgc ggcggtgctc agcgtatcgc ttttgatcgt 1317961 atcgaaggcg tatgcggcat atcaaaccaa tattgaggtg caaaagcttg aggagcaaat 1318021 ttcatccgaa aataagcaaa ttggtgacct cgaaaaaagc gttgctgatt taagcaaacc 1318081 gcagcgcatt atggacattg cgaaaaagaa cggcttgaat ttaaaagata aaaaagtgaa 1318141 aaacatacag gaatgattca aatgccaaaa aagaataaat ttatgaatag aggagcagcg 1318201 attctaagta tttgtttcgc tctctttttc tttgtcatcc tggggagaat ggcatatatt 1318261 caaataaccg gaaaagcgaa cggcgaagtg cttgcgacaa aagcgacaga gcagcatgaa 1318321 aagaaacgga ccatcgaagc gagccgcggc tcgattttag accgaaaagg aaaagtcatt 1318381 gcagaggaca cagcgacgta taaactgatt gcgattctcg ataaaaaaat gaccactgat 1318441 gtcaagcatc ctcagcatgt tgtaaacaaa gaaaaaacgg cggaagcatt gtctaaagtg 1318501 ataaacttgg acaaggccga catccttgat atcttaaata aagatgcaaa acaagtcgag 1318561 tttggctcag ctggccggga tattacgtat tcacaaaagc aaaaaatcga aaaaatgaaa 1318621 ctcccgggca tttcattttt acgggataca aaacgctact atccaaacgg agtatttgca 1318681 tctaatctaa tcggctatgc cgaggttgat gaagaaacaa atgaaatttc cggcgcgatg 1318741 ggattagaaa aagtgctgga taagtatttg aaggagcggg acggatatgt gacatatgaa 1318801 agcgacaaat ccggctggga gctcccgaac agcaaaaata aaattacagc gccaaaaaat 1318861 ggtgacaatg tatatttaac cattgaccag aaaattcaaa cctttttgga agacagcatg 1318921 acaaaagtgg cgcaaaagta taatccgaaa aaaatcatgg ccgcagtcgt tgatccgaaa 1318981 acgggcaaag tccttgccat gggacagcgc ccaagctttg atccgaacaa gcgcgatgtg 1319041 acaaactact ataatgattt gatttcatat gcgtatgaac ccgggtccac gatgaagatc 1319101 tttacactcg ctgctgcgat gcaggaaaac gtgtttaatg cgaacgaaaa atataaatca 1319161 gggacatttg aagttggcgg agcacctgtt aaggatcaca ataacggtgt aggctggggt 1319221 ccgacaacat atcatgacgg cgtcctaagg tcgtcgaatg tcgcttttgc gaaactggcg 1319281 aaagaaaagc tgggatatga ccgcctcaat caatatttgc acaaattcaa tttttaccag 1319341 aaaacaggta ttgatttgcc aggagaagtc tccagcaaaa tcaactttaa atatgaattt 1319401 gataaggcgt caactgcata tggccaagcg tctgcggtca caccaattca gcagattcag 1319461 gccgcaacgg caattgcaaa tgacggtaaa atgatgaaac cttatgtcat tgaccatatc 1319521 gttgaccctg ataaagataa aactatttat caaaataagc cggaatcagc cggaactcca 1319581 atttctgcaa gtactgcgaa aaaggtgcgg gatatattag gagaagtcgt tacatcgaag 1319641 atcggaacag ggcaagctta taaaatcgaa ggttttgatg ttgccgggaa aacaggtact 1319701 gcgcaaatag ccggtaaagg cggatattta gacggcacag ataactatat cttttcgttt 1319761 atgggtatgg cgccaaaaga tgatcctgag cttttaattt atgttgctgt acagcagccg 1319821 caactaaaag caggacaaag cagttcagat ccagtatcag aaatcttcaa tccaacaatg 1319881 aaaaatagcc tgcactacct aaacatcgaa ccaactgaaa aatctgactc agataaggaa 1319941 gaaacaaaag cgcagacaat gcctgattta acagatcaaa cggtagctgc tgctcaaaag 1320001 aaagcaaaag aggagaatct cacaccaatt gtcatcggca gtgatgtcgc tgtaaaagaa 1320061 cagtatccga aagcggatga ggaagttctc accaatcaaa aggtcttcct gaaaacgggc 1320121 ggcaaaatca aaatgcctga tatgacaggc tggtcgagaa gagaggttct gcagtacggc 1320181 gagctcgcgg gaattcatat tgaagtaagc ggacaaggct acgctgtcag ccaaagtgtt 1320241 aagaaagaca aagaaatcaa agacaaaacc gtaatcaagg ttaagtttaa aaatcctgat 1320301 taaaaagaaa gccgtcgtta tgcaggcttt ctttttttat gccttcagag gagcatcgtt 1320361 ctacctgtcc aaattcaggc ataaaatgaa acaagcctaa ataaggagtg aacggtctct 1320421 tgcgcgtctc gaatgtaacg gttagaaaac gtttattatt tgttttgctt tttggcgtga 1320481 tcgtgtttct gatcattgat acaaggctgg ggtatgttca gtttgtgatg ggcgaaaaac 1320541 tgacttcgct agcgaaagat tcctggagcc ggaacttgcc gtttgagccg gagagaggcg 1320601 agattctgga tcggaatggt gtgaagctcg caacaaataa aagtgcgccg accgtattcg 1320661 tcgtgccgcg ccaagttcag aatccgatga aaacgagcaa gcagcttgcg gcggtgctca 1320721 atatgtcaga agaaaaagta tataaacatg tgacaaaaaa agcgtcaatc gaaaagatca 1320781 ctcctgaagg gagaaaaatt tcaaatgaga aggcgaaaga aatcaaagcg cttgatttaa 1320841 aaggtgtgta tgttgcggag gacagtatcc gtcattaccc gttcggcagc tttttatctc 1320901 atgtgcttgg atttgcagga attgacaacc aagggctcct tggacttgaa gcctattacg 1320961 acgatgattt aaaaggggaa aaaggttctg ttaagtttta tacagatgcc aaggggaaga 1321021 agatgcctga tgaagcggat gactatacgc cgcctaagga tgggcttgat atgaagctga 1321081 cagttgattc aaaggttcag acgataatgg aaagagagct tgataacgct gaggccaaat 1321141 atcatccgga cggcatgatt gccgtagcca tgaatccgaa aaacggagaa attttgggga 1321201 tgtctagcag gcctgacttc gaccctgctg attaccaatc tgttgatccg tccgtctaca 1321261 atcgaaatct gccagtatgg agcacgtatg aaccgggatc tacctttaaa attattacac 1321321 ttgcagcagc ccttgaagag caaaaagtaa atttgaaacg ggatcaattt tatgataaag 1321381 ggcatgctga agtggacgga gcgagactgc ggtgctggaa aagaggcggg cacgggctgc 1321441 agacgtatct ggaagttgtg cagaactcct gcaacccggg gtttgttgaa ttaggcgagc 1321501 gcttaggaaa ggaaaagctt ttcaaatata tcaaagactt tggttttgga caaaaaacgg 1321561 ggattgatct ccaaggcgag ggaacaggca tcttattccc gcttgagaga gtgggcccgg 1321621 tggagcaagc aactacggct ttcggacagg gagtatccgt cacgccgatt cagcaggttg 1321681 cagcagtatc cgccgctgta aacggaggaa cgctctatac accttatatt gcaaaggaat 1321741 ggatcgatcc tgttacgaag aaaacggtca aaaaacaatc accaatcgca aagaaacaag 1321801 tcatttctga ggaaacatcc aaacaaatcc gctatgctct agaaagcgtc gtcgcagaag 1321861 gaaccggccg caatgcattt gtagaaggat atcgtgtcgg aggaaaaacg ggaactgcac 1321921 aaaaggttaa agatggaaaa tatcttgaaa acaaccatat tgtatcattt atcggtttcg 1321981 cgccagcaga tgatccgagt ctagtcgtct acgttgcggt ggataacccg aaaggcacga 1322041 ttcagtttgg cggaacggtg gcagcgccta ttgtcggaaa tattatgaga gacagtctgc 1322101 cggaacttgg tgtgaagccc cggaaaaatc aaatcgagaa aaaataccaa tggaacgaca 1322161 caaaaacaat agaagttccg aatgttgtag ggatgtctgt ctcagatctt gagtcactat 1322221 tggtgaatct caatgtggat gcttccggga aagggagcaa aatcgttaaa caatcgccag 1322281 ctgccggaac gaaagtaaaa gaaggctcaa agatacgcgt gtatttgact gaagaagatg 1322341 aaaaggaggc agccgattga ttcgggctgc ctattctttt attgcagaaa aaatgctgat 1322401 atctttcaag attagctgga tgtatccttt tatttacgct aaaatatgaa ctgtatgctt 1322461 aaaatcatta ccacatcatt tgatgtgact tcaatgataa aaagaacgaa ttagaatgtt 1322521 gagaggtttg atacgatgaa acttacaaag ctgcttacat acttaacaac cgaaccttct 1322581 gtaaacgact cacaagaccc tgaaataact tcaattgaga tggactccag ggaagtaaag 1322641 aaagggagtc tttttgtatg tgtaaaaggg tatacggtgg atggccacga ttttgcgcaa 1322701 aaagcagtag aaaacggtgc agcggctatt gtggcagaaa gagaggtcga tgtgaatgtt 1322761 cctgttatta ttgtccggca gtcacttcgc gcgctcagcg ttttgtctga tgcgttttac 1322821 ggacagccga cgaagaagct tcagctgatt gggataacag ggacaaacgg caaaacatca 1322881 acgacccaca tggtcgatga gattctgaaa aaagcgggaa aacgcacagg cttgatcggt 1322941 acaatgtaca tgaaaatcgg agacgaaaca cttcctgtta aaaacacgac tccggaaagc 1323001 gtcacgctgc agaaaacgtt taagaaaatg aatgacaagc acgttgacac tgcaatcatg 1323061 gaggtttctt cccacgcttt gtctttagga cgcgtccatg gctgtgatta tgatattgcc 1323121 gtgtttacga atttaacaca ggaccatctg gactatcata aaacgatgga tgagtaccgg 1323181 catgcaaaaa gcttgctctt ttcccaactt ggcggggctt tcaaccatga acatccaaag 1323241 cgtgccgtcc tgaatgctga cgatgaggcg agcgcttatt ttgaaaaggt aacagctgcg 1323301 catatctcta catacggaat taaaaacgat gctgatgtga tggcgaagaa catcagtatc 1323361 actgcacagg gcacaagctt tgatctcgtg acaaacaaag gcacgaagca catcacgatg 1323421 tctctcgtcg gacaatttaa tgtgtataac gtgctggccg ctgttgcgac atgtattgca 1323481 gcaggcatac cgtttgaaat catcactgag gctgttgaag aattgcatgg tgtaagaggc 1323541 cgttttgaat tggtcaatca gcagcaggag tttcctgtca ttgtagacta cgcgcacaca 1323601 ccggacagcc ttgaaaatgt gctggagaca tgcagagaca tgacggaagg aaagctattt 1323661 gtcgttgtcg gctgcggagg agacagagat aagacgaagc gcccgaaaat ggctaaaatt 1323721 gctgtggagc tggctgacga gccgattttc acgtcagata acccgagaag cgaagatcct 1323781 cgcgcgattt taagagatat ggaagccgga gtagagaacg catactatca cagtattgca 1323841 aaccgcgagc aggcgatctt tttcgcaatt gccaatgcca aaaaaggcga cgttgtcctc 1323901 attgccggaa aaggacatga aacctatcag cagatcggaa atgaaacttt cgattttgat 1323961 gatgctgaag tagcggcgag agccattgtt gaactcaata agaataagac gaattcatag 1324021 gaaagagatg ttactgaata atggagcttg aaaagatttt tcatatggaa aaaaatcatg 1324081 aatatgataa ctacgtatgt cgtttgaaag aaacaggagg agaaaaggac aatgcttgag 1324141 caagtcattc tgtttacaat tttaatgggg tttttaatta gtgttctgct ctctccgatt 1324201 cttattccgt ttttaagaag attaaaattc ggccagagta ttagagaaga aggaccgaaa 1324261 tcacatcaga aaaaatcagg gacaccgaca atgggcgggg tcatgatcat actttctatc 1324321 atagtgacaa caattgttat gacacagaag ttttcagaaa taagccccga aatggtgctg 1324381 cttctgtttg ttacgctagg ctacggtttg cttggctttt tagatgatta catcaaggtt 1324441 gtcatgaagc gcaatcttgg attgacatca aagcaaaagc tgatcggaca aattattatt 1324501 gcggttgtat tttacgccgt gtatcattac tacaattttg cgacggatat tcgcattcct 1324561 ggaactgact tatcatttga tcttggctgg gcttacttta tccttgtgct ctttatgcta 1324621 gtcggcggat caaacgcagt taacctgact gacggccttg acgggttatt atccggtact 1324681 gcggcgattg cctttggcgc ctttgccatt ctggcatgga atcagtctca atatgacgta 1324741 gcgattttct cagttgccgt tgtcggtgca gttctgggct tccttgtatt taatgctcat 1324801 ccggccaaag tttttatggg agatacggga tcgcttgcat tgggaggagc catcgttacc 1324861 attgccattt taacgaaatt agagatcctg ctggttatca tcggcggtgt attcgttatc 1324921 gagacattat ccgttatttt gcaggtcatc agctttaaaa cgacaggtaa acgaatcttt 1324981 aaaatgagtc cgcttcatca ccattatgag cttgtcggct ggtctgaatg gagagtagtc 1325041 gtgacgtttt gggctgcggg acttttgctt gccgttttag gaatttacat cgaggtgtgg 1325101 ttataagtgg aaaatgatca atttttacag aaacagcatt ttttaatcct tgggcttgcg 1325161 aaaagcggat atgcggcggc ctccattctt catgaaaaag gcatttatgt tgcagtcaat 1325221 gatcaaaagc cttttgaaga aaatgaaccg gcacaaaagc tttctgaaaa aggaatcgaa 1325281 gttgtttgcg gagagcatcc agtttctctg ttcgatcagc atcaaatcac gattctgatc 1325341 aaaaacccgg gaattcctta tgaaaatatc atggttcagg aagcagagaa acgaggtatt 1325401 ccggtttgga cggaaattga gctcgcttac tacctgacca gcgccaagtt tatcgggatt 1325461 accggatcga acggtaaaac gaccacgaca acgctaattt acgaaatgct caaggctgac 1325521 tcgcaaaaag cactgattgc cggaaacatc ggcacagtcg caagtgaggt tgcctatcat 1325581 gctgatggag atgaatggat cgttaccgaa ctgtcttcgt ttcagctgat gggaacacac 1325641 gctttcagac cggaaatcag cctgatttta aatgtatttg acgcccatct ggattatcac 1325701 catacgcgcg aaaactatga aaaagcgaaa cagaaagtgt accttcatca gactgcttca 1325761 gataaagcta ttgtcaacca ggatgatgaa accgtcgtgc gtcttgctga agccggaaaa 1325821 gccgaaatcg tcccattttc agtcagcaaa acgcttgaac agggcgcata tgtaaaagac 1325881 agtatgatta tgtttaacgg cgaagccatt cttcctctgg aagaggttgt actgcccggt 1325941 gctcataacc tggagaacat tttagcagct attgcagttg tgaaaacggc aggagcatcc 1326001 aatgaggcgg ttaaaaaggt gctgacaagc tttactggtg tgaagcaccg cctccaatat 1326061 gtcacaactg tgaatggccg caaattttat aacgacagta aagcaacaaa cattctggcg 1326121 acaagcaagg cgctttcagc ttttgataag ccggtcattc tgcttgcggg cggactggat 1326181 cgcggaaatg gttttgatga cttgaaacct tatatgaagc atgtcaaagc agtgcttaca 1326241 tttggccaga cggcgccaaa actcgagaaa ctcggcaatg aactgggaat acaacatgtc 1326301 aaacgtgtcg ataatgttga acaagcagta tctgcggcgt ttgcgctctc aaatgaagga 1326361 gatgtcatcc tgctgtcacc cgcgtgtgcg agctgggatc aattcaaaac atttgaagaa 1326421 cgcggtgaca tgtttataga tgccgtgcat atgcttaagt aagggcttgt cttgaagtaa 1326481 atcggcagcc ctaatgactt taagcttggg gtgtcgattg ctttgactac taaaaaaaca 1326541 tcgcctgatt tgttattggt catcattacg ttattattat taacaatcgg attaattatg 1326601 gtgtacagtg cgagtgcggt atgggcggat tataaatttg acgactcatt ctttttcgcg 1326661 aaacggcagc ttttgtttgc gggaatcggc gtcattgcta tgttttttat catgaatgtt 1326721 gattattgga cttggaggac atggtccaaa ttgctgatgg ttatctgctt tttccttctg 1326781 gtgcttgttt tgataccggg cgtcggaatg gtgcggaacg gttcaagaag ctggatcgga 1326841 gtcggagcat tcagcataca gccttcagag tttatgaagc ttgcgatgat tgcattcctt 1326901 gctaaatttc tctctgaaaa acaaaaaaac atcacatcgt tcagacgggg gttcgtccct 1326961 gcacttggca tcgtgttttc agcatttttg attatcatgt gccagcctga cctcggaacg 1327021 gggacagtta tggtcggaac ttgtattgtc atgatttttg tagccggcgc acggatcgcc 1327081 catttcgtct ttctcgggct gatcggcctc agcggatttg tcgggctcgt actatcggct 1327141 ccatatcgga taaagcggat tacctcatac ttaaatccat gggaagaccc gctcggaagc 1327201 ggatttcaga tcattcaatc gctttatgca gtggggcccg gcgggttgtt cggaatgggg 1327261 ctcggacaaa gcagacagaa gttcttttat ctgcctgagc cgcaaacaga ctttattttc 1327321 gccatcttgt cagaggagct gggctttatc gggggaacac ttattttgct cctcttcagc 1327381 gtcctgctgt ggagaggaat cagaattgcg cttggtgcgc ctgatctgta cggaagcttt 1327441 gtcgcagtcg gcattatttc aatgattgcc attcaagtca tgataaatat cggcgtagtc 1327501 acgggcctga ttcctgtaac aggcatcacg ctcccgtttc tgagctacgg aggctcttca 1327561 ttgactctaa tgctgatggc agttggtgtg ctgctgaatg taagccgcta ctcgaggtat 1327621 taacgaatgt atttccaagc ctcctgtcta acatgaagct tggaaacaat tgatgcgata 1327681 accctgtcca acaaaacagg gttatcgtta tgttatagag aaacttagac tgggggaaaa 1327741 aagaaatgcg aattgcaata agcggaggcg gtacaggggg acatatttat cctgctcttg 1327801 cttttattaa agaagtgcaa agacgtcatc ctaatgtgga atttttatat atcggaacag 1327861 aaaacgggct ggagaaaaaa attgttgagc gggagaatat accgtttcgt tcaattgaaa 1327921 ttacaggatt taaaagaaaa ttgtcatttg aaaatgtcaa gactgtgatg cgttttctga 1327981 agggcgtcaa aaagagtaaa tcgtatttag cggaatttaa gcccgatgcc gtaattggaa 1328041 cgggcggtta tgtatgtggg ccggttgtct atgccgctgc gaaaatggga attccgacta 1328101 ttgtccacga acaaaacagc ctgccgggca tcacgaataa gtttctttca aaatatgtta 1328161 ataaagtagc gatttgtttt gaagaagcga aatcacattt tcctagcgag aaagttgtat 1328221 ttacgggaaa cccgagagcc tctgaagtcg tctcaataaa gacgggacga tcattggctg 1328281 aatttgggct ttctgaagac aaaaaaacgg tcttaatttt cggcggaagc cgaggcgctg 1328341 caccgattaa ccgcgctgtc attgacatgc aggatgtgct gaaaacaaga gactatcaag 1328401 tgctgtatat caccggtgaa gttcactatg aaaaagtaat gaatgagctg aaaagcaagg 1328461 gtgccgctga taatatggtc acaaagccgt ttcttcatca aatgcctgag tatttaaagg 1328521 ccattgatgt cattgtggcc agagccggtg cgacaacgat tgccgaaatt actgctctcg 1328581 gaatcccaag tgttctgatc ccaagtccat atgtgacagc gaatcaccag gaggtcaatg 1328641 cgaggtctct tggccagcat gatgcggcga ttgtactgaa agaaacagag ctcagcgggg 1328701 agaagctgat tgaagcgcta gaccggattg tactgaatga gcaaacgtta aaggaaatga 1328761 gcgaacgaac aaagtcactc ggtgttcctg acgcggctgc ccgtttatac agcgtactcg 1328821 aggaattaaa aaaatagtag aaaagcaaat ggaatgcgga ggtttacgat ggagaaagtg 1328881 atacaggaat taaaagaacg agaagtcggc aaggttcttg caaatgaacc gctcgcgaat 1328941 catacaacga tgaaaatcgg cggacctgcg gatgtattgg tcattccaag cagtgtggat 1329001 gctgttaaag acatcatgga cgtgattaaa aaatatgatg tgaagtggac agtcatcggc 1329061 cgcggatcaa atcttcttgt tttagatgaa ggaattagag gcgtagtgat caagctgggg 1329121 gcgggtcttg accatttgga gcttgaaggg gaacaagtaa cagtcggagg cggttattcg 1329181 gtggtccgcc ttgctacatc attgagcaaa aaaggcctgt ccggtttgga atttgctgcc 1329241 ggcattccag gatcagtcgg cggagcggtt tatatgaatg ccggcgctca cggttctgat 1329301 atgagcgaga tcctcgtcaa agcgcatatt ttatttgaag acggaacgat tgagtggctg 1329361 acaaatgagc agatggattt cagctacagg acatctgtac tgcaaaagaa acgcccgggc 1329421 gtttgccttg aagctgtttt gcagcttgag cagaaggata aggaatcaat cgttcagcaa 1329481 atgcaaagca ataaagacta tagaaaaaat acacagccgt attcaagccc ttgtgcggga 1329541 agcatattca gaaatccgct tccgaatcat gccgggaacc ttgtagaaaa agcaggcttg 1329601 aaaggatatc aaatcggcgg tgcaaagata tcggagatgc acggaaactt catcgtcaat 1329661 gcggggggag catcagcaaa agatgtgctt gatctcattg accatgtgaa aaagacaatc 1329721 cgtgaaaaat acgagattga tatgcacaca gaggttgaaa tcatcggcgg aaatcgctga 1329781 ttcaagttct gactgaagct gttcatatga tatactgtaa gcaaacgaca aacggcatca 1329841 tagtatgccg tttgttttgg aatagacaga cttttaacag ctgtttcatt tgaatgaggt 1329901 gaacaggcaa tgaacccggg tcaagaccga gaaaaaatcg ttaacattga agagcggatc 1329961 cctaaaatta aagagcagag gaaacaaaag gcaaaccgcc gtctcatttc atttattatg 1330021 ctctttttta ttatggtgct gatcattgtg tacctgcaaa caccaatcag taaagtatca 1330081 acaatctctg ttacagggaa tgaaaatgta tcaaaaaagg aaattatcga cctttccgat 1330141 attaacagcg gagatactga gttttggagt ttggacaagc aaaaaacaga aaagaagatt 1330201 cagcaaaata aattagtgaa aaaagcggag atcagcaaat cgcttcctaa taaaatcaac 1330261 attgcaatcg aagaatataa agcgattgct tatttagaaa aagacgatgt gtactatgaa 1330321 gtgcttgaaa acggctcagt tctgccaaac gaagtaacgc cggatgatgc cggaccgatt 1330381 ttagtgaatt ggacaaacgc gaagaagcgg tctcaaatgg ccaagcagct cgatgcgttg 1330441 tcaaattcgt taaaacagtc gatttcagaa atttattata cgcctgtaaa aatggatgaa 1330501 aaccgtatta agttgtacat gaacgacggt tatgttgtta cggcatctat taaaacgttt 1330561 gcagaccgaa tgaagacgta tccttctatc atctcacagc taagcagcaa taaaaaagga 1330621 atcattcatt tagaagttgc cacctatttt gaagagtttg ggaaaaacga taaagctgct 1330681 aaaaaggaag atgaaaattg aggggcaaat cagcagtcct tctttccttg attatgctta 1330741 tcgcaggttt tttgatttca ttttcttttc aaatgacaaa agaaaacaac aaaagcgcgg 1330801 ctgagacgga agagtggaaa aaagaatatg cgctgagaga tgaactgctg aaacaagaga 1330861 aagaaaataa gaagtttgaa aaagaattat atcaaaagca aaacaaagtc cgccaggcgg 1330921 aaaataagct gaagaaagag aagtcggaat actataatgt cctcgaagat acagaaaaat 1330981 acaggatgta tattggggaa gtcggtgtgc agggagaagg cgttgaggtg acattggaag 1331041 atgcgtcata cataccggaa ggggagaatg tgaatagtta catcgttcac gaaagccata 1331101 tcttccaagt agtaaacgaa ctgtatatct caggagcggc agctgtcgcc gttaatggac 1331161 agcgtttgac gcatgattcg tatatcaaat gcaatggtcc tgtggtaacg gtagacgggg 1331221 tgcagcatcc cgctccgttt acggtatccg ctattggaga tccagatgtc ctgctgccct 1331281 cgttaaatat cgctggaggc ctaattgatc agctgtcaat ggatcatatt tctgtgtcgg 1331341 cagaaaaaga gaaaaacgta caaatgaaac cgattctgaa aacgaaggaa tgactgaaaa 1331401 agcgggtgaa atagattgaa aataaagcgt tccttcataa gcatcagtgt tcttatggtc 1331461 atcttcggcc tgatgatatc tgttcagttt aattcgttaa agcaccccaa agtccgggat 1331521 acaagagata tgtgggatat tagggaagag ctgacatcag agcagaagaa gcaggaaaag 1331581 ctgctggctg aaataaacaa atatgacaaa ttgctgaata gctattcgca aacgaaagaa 1331641 atgacaaaag aaaccgcgct aaataatacc ttgcaatcct taaaaaaaac agccggcatg 1331701 accgatataa caggtagcgg aattgtcatt acgatttccc cgcttttttc tgaaagctta 1331761 acaggagagc cgatcgaaaa tccgcctccg gatttgctga aaaagctgat aaatgaactc 1331821 aactcctacg gtgcagagca tatctcgatt aatgagcgaa gagttgtgaa tcatacagtc 1331881 atcagagata taaacggcac tacaaaaata gacggatacg cccttgacga ttatccttta 1331941 acagtaaaag tgcttgccaa agatccggac atgttacaca gcagagtgaa ggggtcaggc 1332001 cttgaggatc tttttgcatc tgaaaattta gcattaaaag ccggtaaatc tgaaagcaaa 1332061 ctaacattaa aagcatatga cagaccactg gacgtacaac agctgaaact gcttaaagac 1332121 tgaaaaggag gagaattgtc atgtggctgc ccgtgttggg actggtgctc ggaatagcga 1332181 ttggactaat gacaaactta acgataccga gtgaatactc aaactattta tcgcttgcgg 1332241 tgcttgccgc acttgataca ttaatcggcg gaatcagggc gcatttacaa ggtacatatg 1332301 atgaaatggt atttgtttcc ggtttctttt ttaatattat attggcaata agtttagctt 1332361 ttctgggagt ccatcttggt gtagacttgt atttagcagg tatattcgca tttggagtca 1332421 gattatttca gaatatagcc gttatcagaa gaaatctact aacaaagtgg actctttcta 1332481 aaaaaaataa aaaaaatgtg atataaaaga ggatatacat aggatataac gaatattttc 1332541 aataaacata aaatgtgaaa agcacataaa aatattctgt tgttattttt tgttacacac 1332601 ttgtaaagcc acattcattg tattgttgtt ccgcaaataa tagaatagaa atgatcgaaa 1332661 tgtgaggagg tgccatagaa tgaacaacaa tgaactttac gtcagtcttg acatcggtac 1332721 gtccaataca aaagtgatcg tcggagaaat gacagatgat tcccttaata ttatcggtgt 1332781 gggaaatgta ccgtctgaag ggttgaaaaa aggctcaatc gttgatatag atgagaccgt 1332841 tcattctata agaaaagcgt ttgaccaagc tgaaagaatg gtaggttttc cgcttagaaa 1332901 agctattgtc ggcgttaatg gaaattatat caatattcaa gatacaaacg gtgttgtagc 1332961 agtttccagt gaaaataaag aaattcaggt tgaagatgta cgccgtgtca tggaggcggc 1333021 acaggttgtt tccgtaccgc atgaacagct gattgttgac gtcattccta aacagtttat 1333081 cgtagatgga agagatgaaa tcaccgaccc gaaaaaaatg ctgggtgtgc gtttagaagt 1333141 agagggcacc ttgatcaccg gttcaaaaac aatcttacat aacttactcc gctgcgttga 1333201 aagagctggt attgaaataa ctgatatttg ccttcagccg ctggcagccg gttctgctgc 1333261 attatcaaag gacgagaaaa accttggtgt ggctctcatt gatatagggg gagggtcaac 1333321 aaccattgcc gtattccaga acggacatct cacttctacc cgtgtcattc ctctcggagg 1333381 cgaaaatatc accaaagata tctccatcgg attgagaacg tcaacagaag aagcagaacg 1333441 cgtgaaaaag caacttggac atgcctacta tgacgaagcc tcggaagatg aaatatttga 1333501 ggtaaccgtt ataggcacca atcaaaaaca aacatttaca cagcaagaag cagcgaatat 1333561 cattgaagcg agagtagagg aaattcttga aattgtttca gaagagcttc gcagtatggg 1333621 aattaccgat ctgccgggag gcttcgtgct gacaggagga caagcagcta tgccgggtgt 1333681 catgtctttg gcacaggatg tgctgcaaaa caatgtcaga gtggcaagcc cgaattatat 1333741 cggtgtaaga gatcctcaat atatgacggg agtgggcctg atccaattcg cctgccggaa 1333801 tgcaagaatc caaggcagaa aaataggctt taagatgcct gaagaagcga tacaggaaat 1333861 cgcagtctca tcatctgagg aacaagagca gcatcatcac caaaatgagg tgcagcagcg 1333921 gccaaaagga aaacaaaaaa cacaagccga acataataaa cagagcaaaa tgaaaaaact 1333981 attaagcatg ttttgggaat agatagatag tcattcggca gattaggagg atttagcatg 1334041 ttggagttcg aaacaaacat agacggctta gcatcaatta aagtaatcgg agtaggaggc 1334101 ggcggtaaca acgccgttaa ccgaatgatt gaaaatgaag tgcaaggagt agagtatatc 1334161 gcggtaaaca cggacgctca agctcttaac ctgtcaaaag cagaagtgaa aatgcaaatc 1334221 ggcgcaaagc tgactagagg attgggagca ggtgcgaatc cggaagtcgg gaaaaaagcc 1334281 gctgaagaaa gcaaagagca gattgaagaa gcacttaaag gtgctgacat ggtattcgtg 1334341 acagctggta tgggcggcgg aacaggaaca ggtgccgcac cggttatcgc acaaatcgcg 1334401 aaagacttag gcgcattaac agtcggcgtt gtgacaagac cgtttacctt cgaaggacgc 1334461 aaaagacagc ttcaggctgc aggcggaatc tcggcaatga aagaagcggt ggatacactg 1334521 atcgtgatcc cgaacgaccg tatccttgaa attgttgata aaaacacacc gatgcttgaa 1334581 gcattccgcg aagcggataa cgtacttcgc caaggggttc aaggtatttc tgacttgatt 1334641 gctacacctg gtcttatcaa ccttgacttt gctgatgtga aaacaatcat gtcaaacaaa 1334701 ggatctgctt tgatgggtat cggtattgct actggggaaa atcgcgcggc agaggcagca 1334761 aaaaaagcaa tttccagccc gcttcttgaa gcggccattg acggtgcgca aggcgtcctc 1334821 atgaacatca ctggaggaac aaacctcagc ctatatgagg ttcaggaagc agcagacatt 1334881 gtcgcttcgg cgtctgatca agacgtaaac atgattttcg gttctgttat taatgaaaat 1334941 ctaaaagatg agattgtggt gacagtgatt gcaaccggct ttatcgaaca agagaaggac 1335001 gtgacgaagc ctcagcgtcc aagcttaaat caaagcatca aaacacacaa tcaaagtgtt 1335061 ccgaagcgtg agccaaaacg tgaggaacct cagcagcaga acacagtaag ccgtcatact 1335121 tcacagccgg ctgatgatac gcttgacatc ccgacattct taagaaaccg taataaacgc 1335181 ggctaatgta aaggacaaaa tcgttttcga ttttgtcctt ttttgttttt ctcttcacac 1335241 tttccttctt ataaagtctt tttccctatt gcttccttcg cgagctcgat tatggatggt 1335301 ttacgttttg gaaaaagtaa ggtatcctag ttcgtacaaa gttttatgaa aattaaaaca 1335361 attataaaag gcaataaaga ggaggaccac gatgattttg cagcttgaca atgtctcact 1335421 aaaacggaat gggaaatgga tactgaaaga tattcattgg aaggtggaag aaaaggaaaa 1335481 ttgggtgctt tacggcctaa atggcgccgg gaagacagcg ctgttaaata tgctttgctc 1335541 atattatttt ccaacatcag gcgagatgca ggtgctcggc catgaatttg gcaaaacaga 1335601 gcttggggaa aagctcagac gtaaaattgg cctcgtctca gcagctcttc agcaaaaatt 1335661 gtatccggca gattcagctt ttgaaattgc tttgagcgga gcttacgctt cgattgggtt 1335721 atatgaaacg ccaagtaagg aaaccaggga aaaagcgata ggtttgttag aggacttggg 1335781 agcaattgaa tatgccgatc gccgctatga aaccctttct caaggggaaa aacaaagagc 1335841 attgattgct agagcactaa tggccgatcc ggagctgctg atactggatg aaccagtcac 1335901 aggactggat tttattgccc gggaaaagct gttagatacg attacataca ttgcaaacaa 1335961 agaaaatgca ccatctatcc tttatgtgac tcatcatgct gaagaaattt tgcctgtctt 1336021 tgataaagcc cttttattaa aacagggaga ggtttttgga tccggagaaa taaaggaaat 1336081 gcttactgat caaatacttt ccgctttttt tgatacgcca atccatgtat tatggaatca 1336141 ggatcggccg tttttaacaa gagctgagcc gataacgaat gcctgacaaa tatatataga 1336201 ttcatcctag gggtgctttg cgaagctgag agagactttg tctcaaccct tttgacctga 1336261 tctggatcat gccagcggag ggaagcggtg aaaagcggag tacatcggac tccgtttgtt 1336321 tttattaagc cgtttcatca catttgaaac ggcttttttg attttaaaga ataggagcgg 1336381 atttacattg gatcaacaaa tatactcttt gcaaaaaaaa gtggaagaac ataaggagga 1336441 gcttattcag cttgcgaaaa cgctgatttc ttatcaaaca cctgctccgc ctgcaagaaa 1336501 tacagagggc attcagtctt ggattgcggg atatttaaat gaattgggat tctcgatcga 1336561 caaatgggat gtgtaccctg gagatcccaa tgttgtaggg aagctaaaag gaacagattc 1336621 agcagattat tatagcctga ttatcaatgg ccatgtagat gtggcagagg taaaagagga 1336681 tgaagaatgg aagcacgatc cgtttcatcc cattgaaaaa aacggtctct taatcgggcg 1336741 aggcgcttcc gatatgaagg gcggaatggc ttgtgtgctg tttgctgtca aattaattcg 1336801 tgaagcaagc attgaacttc caggtgatct gattctgcaa tcggttattg gggaggaagt 1336861 tggagaggcc ggcacacttg aatgctgcaa gaggggctac cacgctgatt ttgcaattgt 1336921 cgcggatacg agcgatatgc atattcaagg ccaaggcggt gtcattacag gctggatcga 1336981 aatcaaaagc agtcaaacat ttcatgatgg aacgagacgg aatatgattc atgcaggcgg 1337041 aggaacattc ggagcaagcg caattgaaaa aatggcaaaa atcattgcgg ggctcggtga 1337101 acttgagcgc cactggtcta ttatgaaaag ttatcccggt tttaaaccag gcacaaatac 1337161 gattaacccg gcagttatag aaggcggcag acatgcggct tttatagcgg acgaatgccg 1337221 gctgtggatc acagtccatt tttatccgaa tgaaacccat gaccaagtgg cagcggaaat 1337281 agaagattac gtcaatcggc tgagtgacag tgatatttgg cttagggaaa accgccctgt 1337341 attcaagtgg ggaggctcat ctatgataga agacagggga gaaatttttc cggcattgga 1337401 agttgaccct ggccacccag gcgtcttagc gctaactgcc tctcatcaga aagtgaaacg 1337461 ggagtgtcca attattgacg tttctcaatc agttacagat ggcggatggc tgtatgatgc 1337521 cggtattcca tgcgtaatat acggtcctgg agatctgcac aatgcacact ctgtgaacga 1337581 gaaggtatcg attgagcagc tagtagagta tacaaaaatt atactcgatt ttatcatcag 1337641 ctggtgcagc cggaaaaaag aacaatgaca tgaaaatttc ttcttgctga caaggttcag 1337701 cctgcccgtt catatacttg aacaaaagga cggaaaaagg acgtgatgga atgatcagca 1337761 tttcagaatt tcaggtaaag gatgtcgtca atgtctcaaa cggaaaaaag ctggggagta 1337821 ttggtgatat tgatatcaat gtgaccactg gaaaaattca ggcgatcata ctcggaggaa 1337881 atgggaaagt tctcggattt tttggaaaag aagaggaatt ggtcattcca tggcgaaata 1337941 tagtaaaaat cggggaagat gtaatcttag tccgattaag tgaaccacat gcataaacct 1338001 gcttgtctgc cgcagattgg caaatgccgg aagtctcgat tcttccggca catttcattt 1338061 agaaatatgc aaatcggcgc tcaacgaatg cagtaagatg tggtaaaata agtgggaaat 1338121 tccgcttttt taaatgtttg tcgaaaggtt ggatcatcat gaatacatat cacccattca 1338181 gtcttaccac accctcgaca ctcatgatac aagactgggc tcaaacgaat caaaacaaca 1338241 aagaggtcat tgccggattt acgacaaaaa acggcggtgt cagccaaaag ccttttgaat 1338301 cgttaaatac aggattgcac gttcatgaca aagatgcaga tgtagttaaa aatcgtgaat 1338361 atattgccga tatgtttaat actgatttgc agtcttgggt attcgctgat cagacacatg 1338421 ataatcgcgt tcagaaagtg acgcagaggg ataggggaaa aggcgcccgt gagtatcaca 1338481 cggctctaaa agcaacggac gggatctata caaatgaaaa aaatgtattt ttagcattat 1338541 gctttgctga ttgtgtgcct cttttctttt atgatccggt taagtcgctt gtcggagtcg 1338601 cccatgccgg gtggaaaggc accgtcaaac agattggcag agaaatggtg aagcaatgga 1338661 ctgagaagga aggttcaaat ccctcagata tttacgctgt tattggcccg tctatcagcg 1338721 gagcatgcta tacggtagac gaccgcgtca tggatgctgt ccgcgcattg ccggtttcag 1338781 cagaccttgc cgccaatcag acggcaaagg cacaatatca gcttgatctg aaagagctga 1338841 accgtcttat actgatggac agcggtttgg caagtgaaca aatttctgtc agcggtttat 1338901 gcacggaaag cgagccgtct cttttctatt ctcatcgccg cgatcagggg aaaactggac 1338961 ggatgatgtc ctttatcgga atgaaggagg cataaaagat cttgcgtgtt gttgataatt 1339021 tacgacatat aaacgaacga ataaacgaag catgtaacag atcgggccgc agctccgatg 1339081 aagttacggt tattgcagtc acaaaatatg tatcacctga aagagcacag gaggcagtag 1339141 atgctggcat cacctgcctc ggagagaatc gggatgcgga actgctccgc aaacaggaat 1339201 tgatgaaagg gaatccggaa tggcatttta tcggcagtct gcaatcaaga aaagcaaaat 1339261 ctgtcgtcaa ttcggtttcc tatatccatt ccctagaccg gctctcatta gcgaaagaaa 1339321 ttgaaaaacg ggctgaaggt actgtacgat gctttgtgca ggtcaatacc tctcttgagc 1339381 cttctaaaca tggcatgaaa aaagaagaag tcattccatt catacaggag ctttccggtt 1339441 tcgaacatat ccttgttgcc gggctgatga caatggctcc gctgactgat gatcaagatc 1339501 agatcagaag ctgtttcagg tcgctgagag aactccgtga ccaggttcag aagctgaacc 1339561 agccgaacgc tccgtgtact gaactgtcga tgggcatgtc aaatgatttt gaaattgcaa 1339621 ttgaagaagg agctacttat attagaatcg gctcatcgtt agtcggaaat gaaacagggg 1339681 gtgtacagca atgagtatga aaaataaact gaaaaacttt ttctcaatgg aagatgaaga 1339741 atacgaatat gaatatattg agacagagcg ggaatctcat gaggagcatg agcaaaaaga 1339801 aaagccggct tacaacggga ataaacctgc gggcaaacag aatgtagtga gcttgcaaag 1339861 tgttcagaaa tcctctaaag tggtgttgag tgagccgcgc gtttatgcgg aggcgcagga 1339921 aatagccgac catttgaaga accggcgggc agttgtcgtc aatcttcagc ggatacagca 1339981 tgaccaggcg aagcggattg ttgacttttt aagcggaacc gtttatgcca ttggcggcga 1340041 tattcaaaga atcggctcag atattttcct ctgcacgcct gacaacgtag atgtatcagg 1340101 cacaatttct gagctcatat ctgaagacga acatcagagg tggtaaagcg agatgatcct 1340161 ttatcaagtt ttttcggttt taagcttatt aatcacaata tactcatttg ccctgatcat 1340221 atatattttt atgtcatggg tgccgagtac gagggaaaca gcagtcgggc gttttttggc 1340281 ttcgatttgt gaaccatatc tcgaaccatt cagaaaaatc atccctccga ttgcaatgct 1340341 ggatatttca ccaatcgtag caatacttgt gcttcggttt gcgacaaccg gcttgtgggg 1340401 actttatcgc atgattgcgt tttaatgtga cagtttgata ggggcttggc agcagccaag 1340461 cctctttaca tagaagggaa agacgatgag cgatatatat cagcacttca gaaaagacga 1340521 gcgggccttt attgatcaag cgctcgaatg gaaaagaatt gtccaggagc agtaccggat 1340581 gaagctgacc gactttttag atccccgaga gcaggtcatc ctctctgctg ttacgggaca 1340641 ggcagatgtc gggcttgcct tttccggcgg ctatgacaga gcggagcgga aacgggcgat 1340701 tctgtttcca gagtacatta ctccggaaga atcagatttt gaactgcagg cgtttaacgt 1340761 ccgttatgct gacaagtttg tctcagtaga tcatcgttct ctgcttggtg cattaatggg 1340821 cataggatta aagcggcaaa aattcggtga catcgtgttt tctgagacag cagtgcaatt 1340881 gattgtctca gccgataccg ctgattttgt ggctgcacag ctgacccaag caggcaaagc 1340941 ggcggtcagc ctagagaaaa tcgacttgtc agaccttaac attccagcag ttgatgtcga 1341001 aataagagat gacacggttt cttctttaag gcttgacgcc gtctgcgcct ctatgagcag 1341061 gcaatcccgc cagaaatcac agacgcttgt gaaaaacggc cttgtgaaag tgaactggaa 1341121 ggtggttgaa gatccttcat acatagtcgc ggaaggggac atgctgtcta tcagaggttt 1341181 tggccggtgc agcttaacaa aaatcgaagg aaaaaccaaa aaagacaaat ggagagttac 1341241 gtttgaacga caaaaatagt cggtttttca gtttttttct ccatctgtgc gaaatttgtt 1341301 ttataatgtg aactagataa ccgtactgaa atgtaaaaat ggaggtggca tcatgccatt 1341361 aacgccaaat gatattcaca acaagacgtt tacaaaaagt tttcgcggat atgatgaaga 1341421 tgaagtaaat gaattcctag cccaagtcag aaaagattac gaaattgttc tccgcaagaa 1341481 aactgagctt gaagcgaaag tcaatgagct tgatgaaaga atcggacact ttgccaatat 1341541 tgaggagaca ttgaataaat caattttagt tgctcaagaa gcggctgaag acgtaaaacg 1341601 caattctcaa aaagaagcaa agctgatcgt tcgggaagcg gagaaaaacg ctgatcgcat 1341661 tatcaacgaa tcgttatcaa aatcaagaaa aattgcaatg gaaattgaag agctgaaaaa 1341721 acagtctaaa gtgttcagaa cacgtttcca aatgctgatt gaagctcagc ttgatcttct 1341781 gaaaaatgac gattgggatc atctccttga gtatgaagtc gacgctgtat ttgaggaaaa 1341841 ggaataaatt ctctgattat cttgacattt tcttagcttg tcgaatataa tacgttcata 1341901 aattcagatg aaaaaacggt tgaaagggac agtcatgttt ccttcaggcc ttcatagcga 1341961 cccggagatg gtgagagtcc gggatggccg gaatcatgta gatcagccct ttagtttcct 1342021 tgctgaactc acagtaggtt aggacgttca tcacgttacg atgctcaaga ggaaaaagtg 1342081 tatgcttgct ttttctaaaa gggtggtacc gcgagataag ctttctcgtc ccttatggga 1342141 tgagagggct ttttttattt tctgaaaaaa tgcagtggag gaatgaaaat ggattttaaa 1342201 gacacgctct taatgccgaa aacagatttc ccgatgcgtg gaaatttgcc aaaccgtgag 1342261 cctgacattc aaaaaaaatg ggaggaagaa gatatctacc gtcttgttca ggaacggacg 1342321 aaagaccgcc cgaaatttgt tttacatgac ggacctccgt atgcaaacgg cgacatccat 1342381 atgggccatg cacttaacaa gattttgaaa gacttcattg tccgctataa atcaatgagc 1342441 ggctacaacg caccgtatgt gccgggctgg gatacacacg gattgccaat tgaaacagct 1342501 ctgacaaaaa acaaaaaggt caaccgcaaa gaaatgtcag tagcggaatt ccgcaaacta 1342561 tgcgaagagt acgcttggaa gcaaatcgag ggacagcgtg agcaattcaa acgtcttggt 1342621 gtccgcggtg actgggaaaa cccatatgtg acattaaaac cggaatacga agcgcagcaa 1342681 atccgcgtat ttggtgaaat ggcaaaacga ggctacattt acaaaggcct taaaccggtt 1342741 aactggtcac cttcaagtga gtctgctctg gctgaagccg agatcgaata tcaagataaa 1342801 cgttcagcat ctatttacgt cgcttttggt gtaaaagacg gaaaaggcgt tcttgaaaac 1342861 ggcgagcgca tcatcatttg gacaacaacg ccgtggacaa ttccggcgaa cctcggaatc 1342921 tcagtgcacc ctgatcttga gtacagcgtg attgcagtag gtgaagaccg ctttgttgta 1342981 gcaagtgcct tagtcgaaaa tgttgcatcg gcatgcggat ttgatcagta tgaagtgaca 1343041 agaacggtca aagggaaaga ccttgagaac attatcgctg aacacccgct atatggcaga 1343101 gactctctcg ttatgcttgg tgaacacgta acaactgatg ccggaacagg ctgtgttcat 1343161 acagcgcctg gacatgggga agatgacttt atcatcggcc aaaaatacgg tttagatgtg 1343221 ctttgcccgg tcgatgaaaa aggtgtaatg acaagcgaag ctcctggctt tgaaggcatg 1343281 ttctatgatg atgcaaacaa agcgatcaca cagcagcttg atgaaaaagg cgcacttgtg 1343341 aagcttgaat tcattactca ttcttatccg catgattgga gaacaaaaaa accaaccatt 1343401 ttcagagcaa cagcgcaatg gtttgcgtct attaaagatt tcagatcaga cctgctggat 1343461 gccattaaag aaaccaaatg ggttcctgaa tggggcgagc agcgtttgca caacatggtt 1343521 cgggaccgcg gagactggtg tatttccaga cagcgtgcgt ggggtgtgcc gattccggta 1343581 ttttacgctg aaaacggaga accggttatt acagatgaaa ccattgaaca tgtttctgaa 1343641 ttgttcagac agcatggatc aaacatttgg tttgaaaaag aagcaaagga tcttcttccg 1343701 gaaggcttta cgcatcctgg cagcccgaac ggcacattta caaaagaaca ggatatcatg 1343761 gatgtttggt ttgattcagg ctcttcacat caagcagtgc ttgaagaacg tgatgacctc 1343821 gttcgcccgg ctgatctata cctagaggga tctgaccaat atcgcggctg gtttaactct 1343881 tctctttcta cagcagtagc cgtaacaggg aaagcgccgt ataaaggtgt gctcagccat 1343941 gggttcgcac tggatggaga aggacgtaag atgagtaaat caatcggtaa cgttgttgtt 1344001 ccggctaaag tcatgaaaca gcttggtgcc gacatcttaa gattatgggt atcttcagtg 1344061 gattatcagg cggacgttcg cgtgtctgac gccattctga agcaggttgc ggaagtatat 1344121 cgtaaaatcc gcaacacgtt ccgtttcctt cacggcaacc ttttcgattt tgatccaaaa 1344181 acaaatgcgg tggctgtcga agatcttcgc gaagtggatc agtatatgct gattaagctg 1344241 aacaagctga ttgataaagt gaaaaaagcg tatgatgagt acgaatttgc ggttgtgtat 1344301 cacagcattc ataatttctg cacaatcgaa ttgagctcat tctaccttga ttttgcaaaa 1344361 gatattgtct acatcgagca tgcggatcat ccggatagac gcagcatgca gacagtattc 1344421 tacgaaacgc ttcttgcatt agtgaagctt tcagcgccta tccttccaca tacggcagac 1344481 gaattgtggt ctcatttaac atttgttgaa gagcagagcg ttcagttgac cgatatgccg 1344541 gaaacaatca cggttccaaa cagtgaagcg actgaagaaa aatttgaccg ctttatggct 1344601 cttcgtgatg acgtgttaaa agcattagaa actgcgcgaa atgaaaaaat tatcggtaaa 1344661 tctttggaag caaacctgaa attgtatcca aacaaagaaa acaaggagct cttggcttcc 1344721 ataaaagaaa acctttctca gctgtttatt gtgtctgaac tgacaatcag cgaagaaaat 1344781 gaagcgccga acgatgcgca aagctttgcg acgggtaaaa tcgctgtcga gaaagcggaa 1344841 ggcgaaatgt gtgagagatc tcgtgtgatt tcaaaagatg taggggcaaa tccgaaatat 1344901 cctacacttt cattacgcaa cgctgaaatc gttgaaaaat actatcaaaa ataatgcaaa 1344961 agagcccggc gtaaaagccg ggcttttttt gtgccaagag tgacatcctt tagaacgaaa 1345021 ggaaaaatct tatgggcttt agatcatcat tcacaggcaa caataaagat actacgttaa 1345081 gagcaggagt tgtgaagaat gaatgatcaa ctgaccgcaa tttatacgga acttcttctg 1345141 atgaaagaag aattacagtc gagattattt gagtattctt gctttcaggt ttctacaagc 1345201 ccgcaagcag caatcaatca aaaacaaaaa gcaactctga tctatcatat taaagaagaa 1345261 cttcaagacg ttctccttgc attgtccaaa atcgaaaacg gcacattcgg atactgtgaa 1345321 gaaactgggg cccccattcc tcttgcaaag ctggcagtgc tgccgacggc ccgaacagca 1345381 aacgattttc tttattctgt ccaatttgag aaaaaaacgc ttccgatatg gaaatcaacg 1345441 gatatcgaat atggtcaggc actgtatgaa taacagtgtc tgtccggtta atatgcctga 1345501 tatttcttta ctccagtgct ttttattgat aaaatgcata atggattaaa gtaaccgtaa 1345561 actggaggaa cgtttgtgct gtattatatg attgcactac ttattattgc agccgatcaa 1345621 ttgacaaaat ggctagttgt taagaacatg gaacttggcc aaagcattcc gatcattgat 1345681 caggtattct atatcacctc ccatcgcaat acgggtgctg catgggggat attagcgggt 1345741 caaatgtggt ttttctacct cataacaacc gctgttatta ttggtattgt ttattacata 1345801 cagcgttata caaagggaca aaggcttctt ggcgttgccc tcggacttat gcttggcggt 1345861 gccatcggca actttatcga tcgggctgtc agacaggaag ttgtggattt tatccatgtt 1345921 attattgtca attacaatta cccgatattt aacatcgcgg actcttcact atgtgtcggc 1345981 gtaatgcttt tatttataca aatgctgttg gacagcggga aaaagaaaaa ggagcaatag 1346041 catgaatcaa attgatataa ccgcttcaga agaacaaaaa agtgagcgga ttgataaatt 1346101 tttggcatcg actgagaatg attggtcaag aacccaggtt cagcaatggg taaaagacgg 1346161 acaggttgtc gtgaacggaa gcgcggtgaa agcgaattat aaaattcagc cgggtgatca 1346221 ggtgaccgtc actgtacctg aaccggaagc gctcgacgtc ctggcagagc ctatggatct 1346281 ggatatttat tatgaggacc aggatgtgct ggtcgtcaac aaacctcgcg gaatggttgt 1346341 tcacccagca cccgggcatc ttacgggcac acttgtaaac ggtcttatgg ctcattgcac 1346401 agacctttcc ggaataaatg gtgtgatgcg cccgggtatt gttcacagaa tcgataagga 1346461 cacgtccggt ttattaatgg tggcgaaaaa tgatatggcg cacgagtcac tcgtaaacca 1346521 attggtcaac aaaacggtca cgcggaaata tacggcggtt gtccacgggc ttatttctca 1346581 tgatgacggc acaattgacg cgccgatcgg acgggataaa aaagaccgtc aaagcatgac 1346641 tgtgacacgt gatggcaaaa acgctgtcac tcattttcat gtgcttgagc gttttcagga 1346701 ttttacgtta gtggagtgcc agcttgaaac agggagaacc catcaaattc gtgttcatat 1346761 gaaatatatc ggattcccat tagcaggcga tccgaaatac ggcccaagaa aaacaatcga 1346821 ctttaatggc caagcgcttc acgcgggagt tttaggtttt gaccatccac gaacaggaga 1346881 atatgtcgaa tttgaagcgc cgcttcccga ggatatggca gaattaatcg aaaacctcag 1346941 aaaaaacggt tgacagaggg tttcttttct gaaataataa acgaagctga atagattctt 1347001 taaaacagtc cagagaggct gagaaggata acggatagac gggatgcgtg tataggcgcg 1347061 caccttgtcc taaaacccct ctatgctctg gcaggagggg ttttttcttc tatatgaact 1347121 gtgaggtgtc acacattgaa tcaaaaagct gtcattctcg acgaacaggc aattagacgg 1347181 gcgctgacca ggattgctca cgaaatgatc gaacgcaata aaggaatgaa taactgcatt 1347241 cttgtcggca ttaagacaag agggatttac ctggcaaaac gccttgcgga acgcattgaa 1347301 cagattgagg gaaatcctgt tacagtcggt gaaattgata ttactcttta cagagatgat 1347361 ctttctaaaa aaacaagcaa cgatgaaccg cttgtaaaag gtgcagatat tccggtagat 1347421 attacagatc aaaaagtcat tctcgttgat gatgttctgt ataccggaag aacagtcaga 1347481 gcaggaatgg atgcgcttgt tgatgtaggc agaccttcct ccattcagct tgcagtgctt 1347541 gtggacagag gacaccggga gctgccgatc cgagcggatt atatcgggaa aaacatcccg 1347601 acatcaaagt ctgaaaaggt tatggtacag cttgatgagg tagaccaaaa cgatctcgtc 1347661 gccatttatg aaaacgaata atagatcacc tttttaaggg caatccagag aggttgcaaa 1347721 gaggtgcaca acaaaggccc aaaaagtatt cggcaggtct ttgtatgcct ctttgcgtaa 1347781 aaaagcaaag aggttttttt atacagtcat tgagtcatcc taaaatgaaa gtcaacaatc 1347841 agggggaaat catcatgagt aagaaaaaag taaatttagg ggtcagggat gtcccgacac 1347901 ctttctcttg ggtttcattc agccttcagc atttgtttgc catgtttggc tcaaccattt 1347961 tggttccgaa gctcgtcgga atgagtcctg ctgtggcgtt ggtgacaagc ggcatcggaa 1348021 cactggcgta ccttcttatt accaaaggac aaattccggc gtatctcggt tcatccttcg 1348081 cctttatttc tccgatcatt ctggtaaaag cgaccggcgg gccgggagcg gcaatggttg 1348141 gagcgtttct tgcagggctg gtgtacgggc tgattgcctt attgattagg cagcttggaa 1348201 caggatggct gatgaagatt ctcccgcctg tagtcgtagg gcctgttatt atcgtcatcg 1348261 ggctgggact ggcaagcact gcagtaaaca tggcgatgta tgctgatccg aacgcgagtg 1348321 agttggtcta cagcttaaag cactttagtg tcgcaggagt tacgctggca attacgatta 1348381 tttgtgcgat tttcttacga gggtttttaa gcctgattcc ggttctgatc ggaatcatcg 1348441 gcggatacct gtttgccctt actcaaggga ttgtcaactt ccagccggtg cttgacgcga 1348501 aatggtttgc agtgcctgaa tttatcattc cgttcaaaga ttattcaccg tcagttacgc 1348561 tcggcatcgc agccgcaatg gttcctgtcg catttgtcac aatgtcagag catatcggcc 1348621 accaaatggt gctgagcaag gttgtcggac aagacttcat taaaaagcca ggtcttcatc 1348681 gctctattat gggtgacagt gtggcgacaa tcctcgcttc cctgatcggc ggccctccga 1348741 caacgactta cggagaaaac attggcgtgc tggccatcac aagagtattc agcgtctttg 1348801 tcatcggggg cgcggcagtg attgcccttt gcttcggctt tatcggcaaa atttcagcgc 1348861 tgatcagttc agtgccgtca gcggtcatgg gaggcgtctc cttcctgctg ttcggaatca 1348921 ttgcttcaag cggcctgaga atgctgattg acaacaaaat tgattatgaa aacaacagaa 1348981 acctcattat tacatcagtt atccttgtca tcggtgtagg aggcgctttt atccaagtgt 1349041 ctcagggcgg attccaagtg tcaggaatgg cgcttgccgc aattgtcggt gtcatcttaa 1349101 acctgattct tccgcaggcg aaggaagagc aggcagacac atctgaacaa catcatattt 1349161 aaaacctttt aatgaaagtc cagagaggct tggaagggtt atgaagagaa ggaagcttca 1349221 atgctgccct ctatttaacc ataccccgag tctatcttag accggggttt tttttcagcc 1349281 ttaagttgaa aagagagggg aaagaacatg aagcatttaa cgacgatgag tgaacttagc 1349341 actgaggaaa tcaaagattt gcttcaaaca gcacaagagc tcaaaagcgg aaaaacagac 1349401 aatcagctta caggaaagtt tgcagcaaac ctgtttttcg aaccgagcac gagaacgcgg 1349461 ttcagctttg aggtcgcaga aaaaaagctg ggcatgaatg tgcttaacct tgatggaaca 1349521 agcacaagcg tgcaaaaagg cgaaacctta tatgacacga tccggacgct tgaatcaatc 1349581 ggtgtggacg tctgcgtcat caggcacagt gaggatgagt attatgaaga gcttgtcagc 1349641 caggtgaaca ttccgattct gaatgcggga gacgggtgcg gccagcatcc aacacaatca 1349701 ctgcttgatt taatgacgat ttatgaagag ttcaatacgt ttaaagggct taccgtctcc 1349761 attcacggcg acatcaagca tagcagagtg gcaaggtcaa atgcggaagt gttgacaaga 1349821 ttgggtgccc gggtcctatt ttccggccct tcggaatggc aggatgaaga aaatacattc 1349881 ggcacgtatg tctcaatgga tgaagcagtt gagtcttccg atgttgtcat gctgctgcgc 1349941 attcaaaatg aacgacatca gtccgctgtc agtcaggaag gctatttaaa caaatacggc 1350001 ttgaccgtag aacgggctga gcgtatgaag cggcatgcga tcatcatgca tcctgctccg 1350061 gtaaacagag gagtggagat tgatgacagc ttagtagaaa gcgaaaaatc aagaatcttc 1350121 aagcaaatga aaaatggcgt atttatcaga atggcagtga tacagcgtgc cttacaaacc 1350181 aatgtgaaaa gaggagaagc agcgtatgtc atatctcatt aaaaacggct ggatactaaa 1350241 cgaaaatggt gaaaaaacac aagcggatat ccgagtgact ggagaaacca tcaccgcaat 1350301 cggcaagctt gatgcaacgg ataatgaaac ggtaattgat gcaaaaggtt tgctcgtttc 1350361 acctgggttt gttgatctcc acgtgcattt cagagagccg ggcggagaga aaaaagaaac 1350421 tattgaaacc ggggcaaaag cagcggcgcg cggcggctat actacagtag cagcaatgcc 1350481 gaatacgcgg ccggttcctg atacaaagga gcagatggaa tgggtgcaaa acagaattaa 1350541 agaaacatca tgcgtaagag ttcttccata tgcatccatt acgatcagac aaatcggcga 1350601 tgaaatgaca aactttgaag cgttaaaaga agccggggca tttgctttta cagatgacgg 1350661 cgttggtata cagacagcag gaatgatgta tgaagcgatg aaacgggcag ccgcaattga 1350721 caaagcgatt gttgcacatt gcgaggacaa ctccttaatt tacggaggga gcgtacatga 1350781 ggggacattc tccaaagcga acgggctaaa cggcattcct tctgtgtgtg aatcggttca 1350841 tattgctcgc gatgtgctgc tggctgaggc ggcaaactgc cattatcatg tatgccatat 1350901 cagcacaaaa gaatctgtca gagttgtacg cgatgcgaaa aaagcgggaa tcagagtgac 1350961 agcagaagta tcgccgcatc atttgctgct ttgtgatgag gacatcccgg ggctggacac 1351021 aaactataaa atgaatcctc cgctccgcag cccagaagac agagctgctt taattgaagg 1351081 tcttttagac ggaacaattg attttatcgc aacagaccat gcaccgcata cggaagaaga 1351141 gaagaacaca gaaatgaagc tggcgccatt cggaattgtc ggcttagaaa cagcattccc 1351201 gcttctttac acacactttg tcaaaaatgg cagctggtca ctgaagcagc tgattgacta 1351261 catgacaatc aagccatgcg aagcgttcgg tctcccatat ggaacattac aaacggggca 1351321 agctgcggac attacgttaa tcgatttaga aaaagaagca gttatagaca aagagacatt 1351381 tttatcaaaa ggaaaaaata caccattcaa cggcatcagt tgcaccggct ggccggtcgc 1351441 tacaattgcg gcagggaagc ttgcttatga agaggggaga cttgtcaaat gaagagacga 1351501 ttagtactgg aaaacggagc ggtattcgag ggagaagctt tcggaagctt agaacacaac 1351561 atgggagaag tcgtttttaa tactgggatg acaggctatc aggaaatttt atctgatcct 1351621 tcttactgcg gacagatcgt aacattaaca tacccgctta tcggaaatta cggcattaac 1351681 cgtgatgatt ttgaatccat tacccctttt gtcaaagggc tgatcatcaa agaattatgt 1351741 gagctgcctt ccaactggcg ttcagcatac accttagacg agtatttaaa aatgaaaaac 1351801 attcccggac tccagggaat tgatacaagg aagctgacaa gaatgatccg cacggcaggc 1351861 gcgctaaaag gaacattcgc ttcatctgat gaagatatcg aagcagtgct gaaaagactg 1351921 aacgaaacgg aattgccaag aaatcaagta tcccaagtat cagcaaaaac agcatatccg 1351981 agcccgggaa gaggcaaacg cattgtcttg gttgacttcg gcatgaaaca cgggattcta 1352041 agagagctga acaaacggaa atgtgacgtc atcgttgtgc cttacaacat tacagcggaa 1352101 gaggtgcttc agctgaaacc ggacggtatc atgctttcta acggacctgg agacccgaag 1352161 gatgtgcctg aagcgattga aatgattaaa ggtgttcttg gaaaagtgcc attattcgga 1352221 atatgtctcg gccaccaatt attcgcgctg gcgtgcgggg cgaatactga aaaaatgaaa 1352281 ttcggccaca ggggctcaaa ccacccggta aaagagctgg ctacaggaaa agttgcctta 1352341 acatctcaaa accatggata tacagtttcg tctatcagta aaacagaact ggaagtgacg 1352401 catatcgcaa ttaacgacga tacgattgaa gggctgaagc ataaaacatt gccggcattt 1352461 acggttcaat atcatcccga agcctcacct ggtcctgagg atgccaacca tctatttgac 1352521 agattcatcg aaatgatcga aacaacagag aaagaagggg aagcggtatg ccaaaacgcg 1352581 tagacattaa caaaatttta gtaatcggat ctggaccgat catcatcggc caagcagcag 1352641 aatttgacta tgcgggaaca caagcctgtc ttgctttgaa agaagaaggc tatgaagtca 1352701 tccttgtcaa ctcaaaccct gcaacgatca tgacagatac agaaatggct gaccgggttt 1352761 acatcgaacc gctcacacct gaattcctga cacgaatcat cagaaaagag cgcccggatg 1352821 ccattcttcc tacactcgga ggccaaaccg gtttgaatct tgcggttgag ctttctgaaa 1352881 gaggcgtttt ggcagaatgc ggcgtcgaag tgcttggcac gaaactgtct gcgattcagc 1352941 aagctgaaga ccgtgacttg ttcagaacat taatgaatga actgaatgaa ccggtgcctg 1353001 aaagtgagat tatccactcc cttgaagaag cagaaaaatt cgtcagtcaa attggattcc 1353061 ctgtcattgt ccgcccggca tatacattag gcggaacagg cggaggcatc tgctcgaatg 1353121 aaacagagct aaaagaaatc gttgagaacg gcttgaaatt aagcccggta caccaatgtc 1353181 tgcttgaaaa aagcatcgcc ggctataaag aaatcgagta tgaagtcatg agagacagcc 1353241 aggatcacgc cattgtcgtt tgtaacatgg aaaacattga tccagttgga atccatactg 1353301 gagacagtat tgttgtcgcg ccgagccaaa cgctcagcga tcgcgaatat cagctcttgc 1353361 ggaatgtatc gttaaaactg attcgcgcgc ttgggatcga aggcggatgt aatgtccagc 1353421 tcgccttaga tccagacagc ttccaatatt acattattga agtaaatccg cgtgtcagcc 1353481 gttcatctgc ccttgcatca aaagcaacgg ggtacccgat tgcaaagctc gctgctaaaa 1353541 ttgcagtcgg actttcatta gatgaaatga tgaacccggt gacaggaaaa acatatgcag 1353601 catttgaacc tgctcttgac tatgtcgtat ccaaaattcc gcgctggccg tttgataagt 1353661 ttgaatcagc aaacagaaag cttggcacgc aaatgaaagc gacaggtgag gtcatggcaa 1353721 tcggccgcac gcttgaagag tcattgctga aggcagtgcg atcactggaa gcggatgtgt 1353781 atcatcttga attgaaggac gccgctgaca tttcagatga gcttcttgaa aagcgaatta 1353841 aaaaggccgg tgatgaacgc ttattctact tagctgaagc gtacagaaga ggctacacgg 1353901 tagaagacct ccatgaattt tccgctatcg atgtcttctt cttgcataag ctgttcggaa 1353961 tcgtacagtt tgaaaaagaa ttgaaggcca atgcgggcga tacagatgtg ctgagacggg 1354021 caaaagaact cggcttctct gatcagtaca tcagccgtga atggaaaatg aaagaatctg 1354081 agctttacag cttgagaaaa caagcgggga ttgcgccggt attcaaaatg gtagatacat 1354141 gcgcggcgga atttgagtca gaaacgccat acttctatag cacatatgaa gaagaaaatg 1354201 aatctgtcgt tacagataag aaaagtgtga tggtgcttgg ttcgggtccg attcgaatcg 1354261 gtcagggtgt cgagttcgac tatgcgacgg ttcactctgt atgggcaatt aaacaagcag 1354321 gctatgaagc cattattgtc aacaacaacc cggaaaccgt ttcaacagac ttcagcatct 1354381 cagacaagct gtattttgaa ccgcttacga ttgaagatgt catgcacatc attgacctcg 1354441 aacagccaat gggcgttgtc gtacaatttg gcggacaaac tgcgattaac cttgctgacg 1354501 agctttctgc acgcggagtg aaaatccttg gaacttcatt agaagattta gaccgtgccg 1354561 aagaccggga taaatttgaa caagcgcttg gagaacttgg tgttcctcag ccgcttggca 1354621 aaacagcgac atcagttaat caggcggtaa gcatcgcaag tgatatcggt tatccggtac 1354681 tggtacgccc ttcctatgta cttggcggcc gggcgatgga gattgtttac catgaagagg 1354741 aactgcttca ttacatgaaa aatgcagtca aaatcaatcc acagcaccct gtattaattg 1354801 atagatactt gaccggaaaa gaaattgaag tcgatgcagt atccgacggt gaaacagtcg 1354861 tcattccggg aattatggag cacattgaac gtgcgggcgt tcactccgga gactcaatcg 1354921 ctgtttatcc gcctcagtct ctcacagagg acattaagaa aaaaattgaa caatacacga 1354981 tcgcattggc taaagggctg aatattgtcg gtttgctcaa tattcaattc gtcttgtcgc 1355041 aaggcgaggt gtacgtgcta gaagtgaatc cgagatcaag cagaaccgta ccgtttttaa 1355101 gcaaaattac gggtatccca atggcgaatc tcgcaacaaa aatcattctt ggtcaaaagc 1355161 tggctgcgtt tggctataca gagggccttc agcctgaaca gcaaggtgta tttgtaaaag 1355221 cgccggtctt ctcctttgcc aagctgagaa gagtggatat tacgttaggg cctgaaatga 1355281 aatcaacagg tgaagtcatg gggaaagatt cgacacttga aaaggcgctc tacaaagcct 1355341 tgatcgcttc aggtattcaa atcccgaact acggttccgt gcttttaaca gtagctgata 1355401 aggacaaaga agaagggctt gccattgcta agcggttcca cgcgatcggc tacaacattt 1355461 tagcgacgga aggaacggca ggctacctga aagaagcttc cattccagcg aaggtcgtcg 1355521 gaaaaatcgg tcaggatggc ccgaacttgc ttgatgtcat cagaaacgga gaagcgcagt 1355581 ttgtcatcaa tacgctgaca aaaggaaagc agccggcaag agacggtttt agaatcagac 1355641 gtgaatcagt agaaaatggt gttgcctgcc taacatcttt agatacggca gaggcgatat 1355701 tgcgagtgct ggaaagcatg acattccgtg ctgatcaaat gccggcagtc aacacaaatc 1355761 aggaggcggc agtcactata tgaaaaaagc gtatttgaca gtatgttcta accagcaaat 1355821 tgcagaccgg gtgtttcaaa tggttctgaa aggggagctt gtccaagggt ttacaacccc 1355881 tggacagttc cttcatctta aagtgagcga agcggttacg cctcttttga gaaggccgat 1355941 cagcatcgca gacgtcaact ttgaaaaaaa tgaagtcacc atcatttatc gggtagatgg 1356001 ggaagggaca agactcttgt cactgaagca gcagggagaa cttgtggatg tcctcgggcc 1356061 tttgggaaat ggctttcctg ttaatgaagt tcaacccgga aagacggctt tgctggtagg 1356121 aggcggagta ggtgtgccgc ctctccaaga gctgtcgaaa cgcttgattg aaaaaggggt 1356181 aaatgtcatc cacgttttag gattccaatc ggcaaaggat gttttttacg aggaagaatg 1356241 ccggcagtac ggagacacgt atgtggcaac agctgacgga agctacgggg aaaccggatt 1356301 tgtcacagat gtgattaaac ggaaaaagct agagtttgat atcctcctca gctgcgggcc 1356361 gacaccgatg ctcaaggcgt taaaacagga atatgcccat aaagaagtat atctgtccat 1356421 ggaggaacga atgggctgcg gaatcggcgc atgcttcgcg tgtgtgtgcc atacaaacga 1356481 aagtgagaca tcctatgtaa aagtatgtct cgacgggcct gtatttaaag ctcaggaggt 1356541 ggcgctgtaa tgctagaggt gaaattgccg ggacttgatt tgaaaaaccc aatcattcct 1356601 gcatcaggct gcttcggttt tggaaaagaa ttttcacgtt tttatgattt gtcttgtctt 1356661 ggagctatca tgattaaggc tacgacaaag gagccgcgct ttgggaatcc gacgccgcgg 1356721 gtagctgaga ctggtgctgg aatgctcaat gcgatcggtc tccaaaatcc ggggctggat 1356781 agtgtgttgc atcatgagct gccgtggctt gagcagtttg atacaccgat cattgccaat 1356841 gtcgcaggtt ctcaagtcga tgattatgtt gaagtcgcag aacatatcag caaagcgcct 1356901 aatgttcatg ctcttgaatt gaatatttcc tgcccgaatg tgaaaacagg cggaatcgct 1356961 tttggcacga atcctgaaat ggctgccgat ttgacaaaag cggtgaaaga ggtttcggat 1357021 gtacccgttt atgtgaagct atccccgaac gtggctaata tcacagaaat tgcattagcg 1357081 atcgaggaag cgggagcgga cggtcttacg atgatcaaca cactaatcgg catgagactc 1357141 gatttaaaaa ccggcaaacc gatattagcg aataaaacag ggggactttc gggccctgct 1357201 gtgaagccgg ttgccattcg catggtgtat gaagtcagcc agatggtcaa catcccgatt 1357261 atcggaatgg gaggcgtgca aacggctgaa gatgccctgg aatttcttct cgcgggagca 1357321 agcgcagtcg ctgtcggaac agcaaacttt gtgaatcctt ttgcatgtcc agagattatt 1357381 gaacagctcc catctgtttt gctccaatac ggctatcaat caattgaaga atgcatcgga 1357441 aggagctgga atcatgaaaa acaacctgcc catcatcgcg cttgattttg cgtcagctga 1357501 agaaacactt gcgttcttag cgccttttca gcaagaaccg ttatttgtaa aggttgggat 1357561 ggagcttttt tatcaagaag ggccatctat cgtgaaacaa ctaaaagaaa gaaactgcga 1357621 gctattttta gatctaaagc ttcatgacat cccgactact gtaaacaaag cgatgaagcg 1357681 ccttgccagt cttggagtag acctcgtcaa tgttcatgct gccgggggca aaaaaatgat 1357741 gcaggcagct ctcgaaggct tagaagaagg tacgccggct ggaaaaaaac gtccgtcact 1357801 tatcgcggta acccagctga caagcacatc tgaacaaatc atgaaagatg aactgctgat 1357861 cgaaaagtct ctgattgata cggttgtgca ctacagcaaa caggcggaag aaagcggact 1357921 ggatggagtg gtctgctctg ttcatgaagc aaaagccatt taccaagcgg tgtcgccttc 1357981 atttctgact gtcactccgg ggatcagaat gtcagaggac gctgcgaatg accaagttcg 1358041 cgtagcgacg cctgccattg caagagagaa aggttcatca gcgattgtag taggacgctc 1358101 gattacaaaa gcggaagacc cggtaaaagc ctataaggct gtcagacttg aatgggaggg 1358161 aatcaaatct tgaaacaaat catcgcaaaa catctattag acatccaagc tgtattttta 1358221 cgcccgaacg agccgttcac atgggcaagc ggcattttat caccgatcta ctgtgacaac 1358281 cgccttacgc tatctttccc agaggtcaga aacgatgttg cttcaggtat cagcaagctt 1358341 gttaaagagc attttcctga agctgaaatg attgcgggaa cagcaactgc cggtattcct 1358401 catgctgctc ttgcggcgga ccatttgaat cttccgatgt gttatgtgag gagcaagccg 1358461 aaggcgcacg gaaaaggcaa tcagattgag ggagctgtgc aagaagggca aaaaacagtc 1358521 gtcattgaag acttaatttc cacaggaggc agcgtgcttg aagcttgtgc agctttacaa 1358581 gcggccggct gtgaagtgct tggtgtcgtc tcaatcttta cgtacggact tcctaaagcg 1358641 gaggaagcct tcgcaaaggc agaactgcca tactactcat taaccgatta tgatacgctc 1358701 acagaggtcg cgcttgaaaa cggaaatatt cattcagatg atctaaaaaa gctgcaaaca 1358761 tggaaacgaa atcccgagtc aaaagattgg tttaaaaaat aaaaaataaa ttcaaatgat 1358821 gtaaagaggc ttcaaagcct tgctgtactt gaaaacaggc tgtgaggcct gtttttttat 1358881 taatcctata aaaaaagtcg ggttgactta tgttagaatt gtgctaaaat ttactacaaa 1358941 tctaaaaact tatcaagagc ggctgaggga ctggacctat gaagcccggc aacctgcata 1359001 gtttgtaagg tgctacttcc agcaaaatga attccatttt gaaagataag ggctgcatgc 1359061 tgttcctgtc tttctttccg ccggattgaa agttttttat tttaagaggt aaaaaggcta 1359121 tctgtatatc agcagccgcg aatcacatta catgggaaaa gacaaccggc agaaagctac 1359181 tgtttgtttg tctccgaaag gaggaaagaa gaaatgttaa cgtatgataa ttgggaagaa 1359241 ccaacgatta catttccgga agacgatcct tataaaggag cgctgtcagt tttaaaatgg 1359301 gcatacggcc attacggcga tcagcttgtt tatgcctgca gtttcggaat tgagggaatc 1359361 gttctgattg acttaattta taaagtgaaa aaagacgcag agattgtgtt tcttgataca 1359421 ggacttcatt ttaaagaaac ctatgaaaca attgaacgag tgaaagagcg ttatccgggt 1359481 cttaatatca tcctgaaaaa accagatctc acccttgagg aacaagccga agaacatggt 1359541 gacaaactat gggaaagaga gccgaatcag tgctgctatc ttagaaaggt cgttccttta 1359601 agagaggcgc tttcaggaca tccagcctgg ctttccggcc tgcgccgtga tcaagggcca 1359661 agccgtgcca atacgaattt cttaaacaaa gatgaaaaat tcaagtcagt aaaagtttgc 1359721 ccgcttatcc attggacttg gaaagacatt tggagatata catcccggaa tgaactggac 1359781 tacaatccgc ttcatgacca aggctatcca agtattggct gtgcgccttg cacttctccc 1359841 gcttttacag cagaagattt gcgctcaggc agatggaatg gtatggcgaa aacagaatgc 1359901 ggactgcatg aataaggagc tgcaaaatgg aattagccgc tattttattt agcttgtttt 1359961 tcgcgatgaa tattggtgca agcggcgctg cagcttcgat gggggttgct tacggctccg 1360021 gagccatcaa aaagaaaact tacgctttga tcctatgcgc agtcggtgtc tttgccgggg 1360081 cggtcattgg cggaggcgag gttgtaaaaa caatcagctc cggcattatt cctgagcaga 1360141 cgattacact gacgattgtt tgcatcatta ttggagctgc tgccctgtcg ctctttactg 1360201 ctaatctgct cggcattcct ttgtcgacaa gtgaagtaac agtcggcgcg gttgtcggcg 1360261 tgggagtggc ttataaagta ttgtttgtga acaatcttct gatcattgtg tcattttggg 1360321 tttttgtccc gctgttcgct ttcggcttca cctatttcgt atctaagctg tttcgttatt 1360381 ttaagattga agtaaaatct tctaaaaagc aaaaaatcct cggcattgtt ttgttagttg 1360441 ccggattttt cgaagcattc tctgccggca tgaataacgt ggcgaatgct gttggcccgt 1360501 tagtagctgc cggtgtgctt gatgtcggaa aaggaacctt gtatggagga gcttttgttg 1360561 ctcttggcgc actgttatta ggccggcgag tgctagaaac aaacgggaag aaaattacga 1360621 ggttctccaa aggggaaggc attctcttat ccggtacagg agcgggactg gtgatcatca 1360681 gttctgtatt tgggatgccg gtgcccttgg cgcaagtcac gtcatcgtct attatcggaa 1360741 taggcatggc gaaaaacggt ccgaacgtgt tccataaaca agttgttcaa acgatgctga 1360801 aggtatggat cgtatcgccg tttttatctt tatcgatttc ttatctgctt gtatccttgt 1360861 ttttaaaagc agattattat tcgatcttta tcatggtaag tgtgctttta gcggcgggcg 1360921 gtgccatcag cctgacaaag gccattcgta aagagagacg ctcagtccac gaacaaggcg 1360981 ggggaatctg atcattaatc tgagtaattt tataagttaa ctaggaggag atggatatta 1361041 tgagcttagc accacacgga ggaacattag taaacagagt agatgaatca tatgatgtga 1361101 gcggcattca aaaagaaatt gaacttgatt taatttcttt cgcggatttg gaattgatcg 1361161 gtatcggtgc atacagcccg attgaaggtt tctttaatga aaaagattac gtatcagtgg 1361221 tcgaaaacat gcgtctttct tccggcgttg tctggtctct tccaatcacg cttccggtcg 1361281 atgcgcaaaa agcagcggaa ctgtcacttg gtgaaacggt aaagttaacg tatgaaggag 1361341 aaacttacgg cgttatccaa atcgaagacc tgtacgtgcc tgacaaacaa aaagaagctg 1361401 tcaatgtgta caaaacagat gaacaggagc atcctggtgt taaaaagctg ttcagccgcg 1361461 gcaatacata tgtcggcgga ccgattacgt tgattaaaaa agcttcaaaa cagttccctg 1361521 aatttacatt tgaaccgtca gaaacgagac gccagtttgc ggaaaaaggc tgggaaacca 1361581 ttgtcggttt ccaaacaaga aaccctgttc acagagcgca tgaatacatt caaaaaacgg 1361641 ctcttgaaac agtagacggc ttgttcttga atccgttagt aggtgaaaca aaatctgatg 1361701 acattccagc tgatgtacgg atggaaagct accaagtgct tcttgatcat tattacccga 1361761 aagatcgtgt tttccttggt gtctttttag cggcgatgcg ttatgcaggc ccgagagaag 1361821 caattttcca cgcgcttgtc agaaagaact acggctgcac acatttcatc gtcggccgtg 1361881 atcatgcagg tgtaggcgac tattacggaa catacgaagc acaggaactg tttgacacat 1361941 ttaaacctga agaactcgga attacaccgc tgaaatttga gcacagcttc ttctgtaaaa 1362001 aatgcggaaa tatgggaaca gcaaaaactt gccctcatgg cagagagcat cacgtcattt 1362061 tatcaggcac taaggtaaga ggtatgctga gagacggtgt gctgccgcct gctgaattca 1362121 gtcgaaaaga agtagtagaa gtgttaatca aagggatgaa gaaaaaagaa gaagtaggcg 1362181 tatcttaagg aggactggca gtgacaaatc gcgatattgt atggcatgaa gcctctatca 1362241 caaaagaaga gtatcagcaa aaaaacaagc ataaaagctc cattctctgg ctgacagggt 1362301 taagcggctc aggcaaatca accattgcca acgccgctgc gagagaattg tttgagcaag 1362361 gctaccaagt cattgtgctg gacggggata atatccgtca cggcctaaat agggatcttg 1362421 gtttttctga tgaagaccga aaagaaaaca tccgccggat cggagaggtg gcgaagcttt 1362481 ttgttcagca gggaaccatt gtgattactg cttttatctc tcctttccgc gaggacagac 1362541 aacaggttcg cgagcttgtg gaagcgggcg aatttaatga agtctacatt aaatgcgacc 1362601 ttgatatttg tgaacaaaga gatccgaaag ggctttacaa aaaagcaaga aacggcgaga 1362661 ttccgttctt tacaggaatt gattctcctt atgaagaacc ggaagctcca gagctcgttc 1362721 ttgattcagg acagcatgac cgtgaagcgt gtaaaaatca gctgatcgag tttgttaaac 1362781 aaaaattgag ctgaatatga tctgctgcgt tcttctcaga tgccggaatg caagcgagaa 1362841 catcatcaca gcgaatcttc tggaagaact cgaatagatc gggggaaata cgatggggaa 1362901 agtatatatt gtaggagcgg gtcccggtga ccctgatctg ctgacaatta aagcgctgaa 1362961 agccattgaa aaagctgatg tcatcttata tgacagatta gtaaataaag agattttaca 1363021 atatgccaaa gagcaagcag acctgatcta ctgcgggaag cttccggatt ttcatacgat 1363081 gaagcaggaa accatcaatc gatttcttgt gaagtatgcg caaaaaggga aaatggttgt 1363141 cagactgaaa ggcggagacc cttttgtgtt cgggagagga ggggaagaag cggaatgcct 1363201 ctctgaaaat ggaattccgt ttgaaatcat tcccggcatt acgtctggaa tcgcggcagc 1363261 cgcttatgcc gggattcctg ttacccatcg ggatgcgggc tctaacgtcg cttttgtaac 1363321 gggtcactat aaaaaagaag aagattttga ggaaaagtgg aaagcgctgg ctacaggaat 1363381 tgatacactt gtcatctata tgggtatcaa aaacgtgcag cagattgaaa gaaaactcct 1363441 tgaaaatggc cgggacggtt ctacgccagc agcctttatt cattggggga caacggacaa 1363501 gcaaaaatct gttttttgta cagttgacac cctttcagaa acggtgataa aagaaaacat 1363561 tacaaatccg agtttaattg tcattggaaa tgttgtaaat tatcactata agctggaatg 1363621 gtttgaatct gaactaaaaa aacaagattt aagcgaggcg ttgtaaaaat gaaacaagca 1363681 attttatatg tcggccacgg cagccgggtc aaaaaagcgc agcaagaagc cgcagccttt 1363741 ttggaaggat gcaaggccca catctctgtg ccagtacaag aaatcagctt tttagagctt 1363801 caggagccga caattgagac aggatttgaa gcatgtgtga agcaaggtgc cactcatatc 1363861 gcagtggtgc ctctgcttct tttaacagct gcgcatgcaa aacatgatat tccggaagaa 1363921 attgtccgtg ttgcatctcg atatccatca gtccgtattt catacggaaa gccgatcggg 1363981 attgacgaag aagtagtcaa ggctgtatat caccgaatga aagacatagg tgttccgtat 1364041 gaaaatgcca gagtggtgct catcggaagg ggaagttcag atccagacgt caaaagagac 1364101 gtaaccggaa ttgctaatct tcttcaggaa atggttccag tgaaggaagt cattccgtgc 1364161 tttttgacag catgcggccc taattacaaa gaggtttttt cagaacttga aaaagatgac 1364221 ggcataacaa cctttatcgt tccatatttg ctttttacgg gtatgctgat gaatgaaatc 1364281 gaacgagagg ttcagaaatt aaaagcccat aatccgaacg tctacctctc ttcctatatc 1364341 ggttttcatc ctcatgtgaa aaacgcattt ttgaaccgtg tgagagaaac tgcggcaaat 1364401 tctgagggac aatttgattt tgatggaggt tcatatgctt ccgctgcaca ttagcctgga 1364461 aaagaagaag gttgtgattg cggggggcgg aagcatcgct ctcagaaggc tgaaaacggt 1364521 gatttctgag ggagctgata taacgcttgt cagtccggat gtggaaccgg aaatcaagca 1364581 aatggcagaa gagcggcgta tcaaatggga aaaacggaca attgaaaaag aagattatct 1364641 caatgctttc ttcattattg ctgcgacgga taatgcggca gtgaacaaag aaattgccca 1364701 atccgcttcg ccttttcagc ttgtcaattg tgtcagtgac gctgagcttg gcaatgtata 1364761 tatgccgaaa atcgtaaaaa gagggcatgt cactgtgtct gtttctacaa gcggagccag 1364821 tccaaagcac acgaaagagc ttgctgaaaa cgtggataag ctgattgacg gcgattttgt 1364881 tgctgaagtg aacaggcttt atcagatgag aagaaagaaa taagccagag catacaaatg 1364941 ctctggcttt tctttatgcg gctcagcttt ttttgagctt gatgacagta tcagcatcag 1365001 gcgtgacaaa gacggtatgc tggctgtcat aagtgacgaa accgggtttc gcgccgtttg 1365061 gttttttgac atgcctgatt tttgtataat ctacaggcac tgaacttgaa tctttagctt 1365121 ttgaaaaata agctgcaatt gtcgcggctt ccatgattgt ttgctcatca ggttcgctgc 1365181 ttctgatcac aacgtgggag ccgggaatgt ccttcgtgtg aagccagata tcgtctctgg 1365241 ccgccactct tgtcgttaaa tattcatttt gacgattgtt cttacccact aaaattgtca 1365301 gccctgaggt ggattcatat gtttctaaca ccggattgtg cggtttttgc tttttctggc 1365361 ctttttgctg cttagggcgt aaatatttgc cctcaacaag ctcttccctg atttcgctga 1365421 tatcccgggg agaagcggac gaaagctgct gaatcagctg atcaaaatat tcgatctctt 1365481 cctgtgccag cctgatttgc tcctcgacaa ctgcgaccga atttttcgct ttctgatact 1365541 tcgtgaaata ggcctgtgcg ttttcagaag gcgttttgtt cgggtttaaa ggaatcgtga 1365601 ttgtcgggct ttcttcatca taataattga tgacctcagc ctgtttatca ccttttttca 1365661 gcatatataa attagcggtt aaaagctctc cgtaaagctg aaattccttc gcgttttccg 1365721 aatactccag ggttttctct aattttttga ttttgttggc attcttcttc cgttcgttca 1365781 caacaaaacg ctcaagatcc tgagcctgtt gcttaacccg gtctcgttca gcttttccga 1365841 aataaaaacg gtcgagcagt tcgcttaatg aatcaaaacg gcgcgcttcg ccctttagat 1365901 gagtcagctc cagcagataa aaatattcct ttccgtttac agtcgtaatg ttgggaatga 1365961 aacggtgctc tttcacttcg gcaaacagtg ccagcaacgc ttttggcagt gtgactttgt 1366021 tggcaaggcc tgctctgtga accgcttctt tggcgaaaag cggagacacg cctgaaaagt 1366081 ggtcgacaat ttgtttatca agccttcctt cttgaaagct gaggtgacgc aaaatatcat 1366141 cttctgacgc ctcaagaggc gatattttgt cctgagcagg cggaagctta taatcttggc 1366201 cgggcagtac tgtacggtag ctgttcattg acggtgataa atgcttaagt ccgtcgataa 1366261 tcacattttc tgctgcgtca gtcaaaatga tattgctgtg gcggcccata atttctacat 1366321 aaagctttcg tacggtttca tcgccaattt cgtttcggct tttgatatga aaaatcataa 1366381 tgcggtctaa gcccgcttgt tcaattttct caatgaatcc gccttcgata tgctttctca 1366441 gcaacatgca aaacattggc ggttcgcttg gattttcata agcttgtgcc gtgatatgca 1366501 cccgtgaata gctcggatgt gccgataata atagtttttg gttttttccc ttggcacgga 1366561 tgtggaaaat cacatcgtgc ttatatggct gatggatttt tgtaattcgt ccgcccatta 1366621 ttttctcgtt aagttcgtgt gtcattccgt atgtaaacat gccatcaaac gacatatgca 1366681 atacaccctc tcattcttcc tgcattcgat aattatagca tgaaatggga cgagtcagaa 1366741 taagcatgct tatagagtga tatctctata agagagcagg ggagtggacg agcggaatga 1366801 agtttcatga aatgggacaa acagatttac tagaggcaac caatacgtcc atgaaacaag 1366861 gattaacaga aaaagaggta aaaaaacgcc ttgacaagca tggaccaaac gagctgcaag 1366921 aagggaaaaa aacttcagcg cttctcttgt ttttcgcgca gttcaaagat tttatggtgc 1366981 ttgtgcttct ggcggcaacg ttaatctcag gatttcttgg tgaatatgta gatgcggttg 1367041 cgattattgc gattgtgttt gtgaatggca tactcggttt ctttcaagaa aggcgtgctg 1367101 agcaatctct tcaggcttta aaagagcttt caacaccgca cgtcatggca ctcagggaag 1367161 gaagctggac aaagattcct tctaaggaac tggtgccggg tgatattgtg aaatttacga 1367221 gcggggacag aattggcgca gacgttcgaa ttgttgaagc gagaagcctt gaaatagaag 1367281 aatcagcgct aaccggggaa tcaatcccgg ttgtgaagca tgctgataaa ttgaaaaaac 1367341 cggatgtttc actcggcgat attaccaata tggcatttat gggtacgatt gtgacccgcg 1367401 gcagcggtgt cggggttgtc gtcgggacag gaatgaatac ggctatgggg aaaattgccg 1367461 acatgcttga atcggcaggg acattgtcaa ccccgctgca aagaagactg gagcagctcg 1367521 ggaagatttt gattgttgtt gcattgcttc tgaccgtact tgtcgttgct gtcggtgtta 1367581 ttcagggtca tgatctgtac agtatgtttt tagcaggtgt ctcgttagcg gtagccgcta 1367641 ttccggaggg gctgccggcg attgtgacag tggcgctttc gcttggtgta cagaggatga 1367701 ttaaacaaaa atccattgtt agaaagcttc ctgctgttga aacgcttggg tgtgcgtcta 1367761 tcatttgctc agataaaaca gggacaatga cccaaaacaa aatgacagtg acgcatgtct 1367821 ggtccggagg gaaaacatgg agagtggcag gggccggcta tgaaccgaaa ggaagcttca 1367881 cactaaacga aaaagagatc agtgtcaatg aacataagcc gcttcagcag atgcttctgt 1367941 tcggagcgct ttgtaacaac tccaatattg agaaaagaga cggcgaatat gtgcttgacg 1368001 gagatccgac agagggagcg ctgctcaccg cggcaagaaa aggcggtttt tcaaaggagt 1368061 ttgttgaatc taattacaga gtgattgaag aatttccgtt tgattccgca cggaaaatga 1368121 tgactgtcat cgtagagaat caagacagaa agcgctatat cattacaaaa ggtgcgccgg 1368181 atgtactcat gcagcgatct tcccgtattt attatgatgg ctcagcggct cttttttcaa 1368241 atgaaagaaa agcagaaaca gaggcggtat taagacattt ggcatcacag gcgctcagaa 1368301 cgatagcggt cgcctacagg ccgataaaag caggcgaaac accgtcaatg gagcaggcgg 1368361 aaaaagatct gaccatgctt ggcctttcag gtatcattga tcccccgcgg ccggaagtca 1368421 gacaggcgat taaagaatgc cgtgaagcgg gaattaagac cgtcatgatt acaggtgatc 1368481 atgtagaaac cgctaaagcg atagcgaaag acttgcgcct ccttccgaaa agcggcaaaa 1368541 tcatggacgg caagatgctg aatgaacttt ctcaagaaga gctttctcat gtggtggagg 1368601 atgtgtatgt atttgcccgc gtttcccctg aacataaact aaaaatcgta aaagcctatc 1368661 aggagaacgg gcatattgtg gcgatgacgg gagacggcgt caatgatgct cctgccatta 1368721 aacaggctga tatcggcgtc tctatgggca ttaccgggac agatgtggcc aaagaagcat 1368781 catctcttgt tctcgtggat gataattttg cgacgattaa atcagcgata aaagaaggca 1368841 ggaacatcta cgaaaatatc aggaagttta tcagatacct gttggcgtct aacgtcggag 1368901 aaatccttgt catgctgttt gcgatgctgc ttgcccttcc tttaccgctg gttccgattc 1368961 agattttgtg ggtcaacttg gtgacggacg gattgccggc aatggcgctc ggcatggatc 1369021 agccggaagg agacgtcatg aagcgcaagc cccgtcatcc gaaagaaggg gtatttgccc 1369081 gcaagctagg atggaaggtc gtttccagag gatttttaat cggagttgcc actattttag 1369141 cgtttatcat tgtgtaccac cgcaatccgg aaaacttggc ttatgcccag acgatcgcgt 1369201 ttgccacatt ggtgctcgct cagcttattc acgtgtttga ctgccgcagc gaaacttctg 1369261 ttttctctag aaatccgttt caaaacctgt atttaatcgg cgcggtattg tcatccattt 1369321 tgctgatgct tgtagtaatc tactatccgc cgcttcagcc gattttccat actgtagcca 1369381 tcacgccggg ggactggatg ctcgtcatcg gtatgtccgc catccctact tttttgctgg 1369441 cggggtcact tttaacaaga aaaaaataaa ttcatatgat ataatcttag gggtaatagc 1369501 gtgtctattg cccttttatt atgagaacag ggaagaattg ggtgttttaa aatgatacga 1369561 agtatgacag gcttcggcag tgcaagcaaa acacaagacg atctctctgt aagcgttgaa 1369621 cttaaatctg tgaactacag atttaaagaa gtgaacgctc gtttgccaag gcctttgcta 1369681 tattttgaag ataagctgaa acagaccatt ctgcagcata ttcagcgcgg aagaattgag 1369741 cttttcgtat ccgttgacag cgatatgctt gttgagaaaa ggcttgaaat tgattggccg 1369801 ctgctcgatg agtttgtcgc agccgcgaga gatatgaaga agcggtatca attgtctgca 1369861 gagcccgatg taatggattt ctttaagctt gatcatgtcg tccaggttca tgaagaacag 1369921 acgcaaaatg acaagctgga ggcgttgatc atcgatgctg cagaagaagc ggtaaaaggt 1369981 ctctgtgaaa tgcgtgaaaa agaggggctg ctcttagcga aagactgcct gatgcatatt 1370041 gatcagcttg aagagctggt gagagaaact gaattgctgg ctgcagatgt cgtatctcgt 1370101 taccgggaac ggctgtatgc cagaatcaaa gaatggactg aagacgtatt agacgagagc 1370161 cggcttgtaa cagaatgcgc tatttttgca gaccgctctg atatcactga agagattaca 1370221 aggctgaaga gccacttcgc ccagtttcgt gatatattag ctagtggcgg agctgtcggg 1370281 cgcaaactcg actttcttgt tcaggagctc aatcgggaag caaatacgat cggctcaaaa 1370341 gcaaatgatc atcagatcac aaagcttgtc gttgaaatga aaagttctat tgaaaaaata 1370401 aaagaacaag tgcaaaatat agaatagtga ctgtgcgtat tgtttacaga cggtcttact 1370461 aggctaaact agagacgtct attttacagg gggaacgtag aagatgacga ttaaactgat 1370521 taatatcgga tttggcaata tcatctccgc caatcggatg atttcgattg tcagcccgga 1370581 gtctgcgcca atcaaacgga tgattcagga tgcaagagac cgcggaatgc taattgacgc 1370641 tacatacgga cgaagaaccc gtgcagttgt cgtcatggat agtgatcaca ttatcttatc 1370701 tgccgtccag cctgagacag ttgcacacag actttctgtt aaagaagaaa ttatggatga 1370761 agggcagggg taattgccgc atgaaagaaa gagggttatt aatcgttctc tcaggtccct 1370821 caggagttgg taaaggaacg gttcgacaag cgatcttttc gcaggaagac acaaaatttg 1370881 aatattcgat ttcagtaacc acaagaagtc caagagaggg cgaagtgaac ggagtcgatt 1370941 attttttcaa aacaagagac gaattcgagc aaatgattgc ggacaacaag ctgcttgaat 1371001 gggcagagta tgtcggcaat tattacggca cgccagtcga ttatgttgaa cagacgcttc 1371061 aagatggaaa agacgtcttt ttagaaattg aagttcaagg ggctcttcaa gtgagaaatg 1371121 ctttcccgga aggcctgttt attttccttg cgcctccaag cctttctgaa ctgaaaaaca 1371181 gaatcgtgac acgaggaaca gaaacagacg ctctgattga aaatcgaatg aaagccgcaa 1371241 aagctgagat cgaaatgatg gatgcttatg actatgtcgt tgaaaacgat aatgtcgaaa 1371301 cggcttgcga taaaatcaaa gcaatcgttc ttgctgaaca tttgaagcgt gaacgcgttg 1371361 caccaagata taagaaaatg ctggaggttg aataatcaat gttagatccg tcaattgatt 1371421 ctttaatgaa taaattagat tcaaaatata cgctggtgac tgtttctgcg agacgtgccc 1371481 gtgaaatgca aatcaaaaaa gaccaaatga ttgaacatac gatttcacac aaatatgtag 1371541 gcaaagcttt agaagaaatt gatgcaggcc tgctttcgtt tgaaaaggaa gaccgcgaat 1371601 agtagcacaa gtagcaacct atatcatgta ggttgttatt tttttccgtg cggttttgta 1371661 aagtgcagag ggggagaatt cattgcttaa caatcgaaat gtgttacttt gcgtgagtgg 1371721 aggcatcgct gtttataaag cctgtgcgtt aacgagcaag ctggttcagg caggagcaaa 1371781 tgtcaaagtg attatgactg aatccgcttg ccgattcgtt tcaccgctga catttcaggc 1371841 attgagccgc cacgaagtct atacagatac atttaaagaa caaaatccaa gcgtcatttc 1371901 tcatattgat gccgcagact gggccgactt gattatcgta gcgccggcta cggctaatgt 1371961 gattggaaaa ctggcaaacg gcatcgctga tgatatgctg acgacaacat tgttggcagc 1372021 aacggctccc gtttggatcg cgccggcaat gaacgttcat atgtatgacc acccggcagt 1372081 caaacgaaac atttctgttc tttatcagga cggttattgt tttattgagc caagtgaggg 1372141 ctatttagca tgcggttacg taggaaaagg cagattggaa gagccggaaa acatcgtaaa 1372201 gctggccgaa aaacattttg ctgaagaaac atccgctcct ttagaaggca agcatgtggt 1372261 cattacagcc ggcccaacgc gggaagcgat tgatcctgtc cggtttttta ccaataaatc 1372321 gacgggcaaa atgggctacg cactggcgga ggctgctgtt cagctcggcg cacgggtaat 1372381 cttaatttct gggcctgttt cacttgatca gcctaaaggc cttgctgagt ttatccctgt 1372441 tcaatcggct gcggatatgc gcgaagctgt gctctctgtg tatgacgcaa gcgatatagt 1372501 cattaaaaca gctgcggtag ccgattttac gccgaaaaca gtatttgacc ataaaatgaa 1372561 aaaacaagac ggcggcatga ccttagaact gaaaagaaca gtcgatattt tgaaagaatt 1372621 gggcgagaaa aagaaagagc agattttggt cggatttgcc gccgaaacac aagacattga 1372681 acactatgca cgtaaaaagc tcgccgctaa aaaccttgat ttgattgtgg caaatgatgt 1372741 gaaagcaaat ggggccggtt ttggtgctga tacgaatatc gtgacaatct ttttcaaaga 1372801 cgggcataaa cgcgaactcc cgattatgtc taagctcgat gtttcttttg aaatccttca 1372861 ggagatcgca gccctctcaa aacaaaccgg agagcgctca tgaattttgc agaagtcatc 1372921 gttgatgtca gcaccaaaaa tatagacagg ccttttgatt ataaaatccc agaccatctg 1372981 aagggcatga tcaaaacggg gatgcgggtc attgttccgt ttggcccccg taagattcaa 1373041 gggtttgtga cagcagtcaa agaagcatct gacctatcgg gaaaatctgt caaggaagta 1373101 gaggatttat tagatcttac acctgttctg acagaggagc ttatgattct gtcatcatgg 1373161 ctgtcagaca aaacgctgtc ttttaaaata acggcgcttc aagcaatgct gcctgccgcc 1373221 ttaaaggcga aatatgaaaa agaattaaaa attgcacacg gagccgatct tccgccgcaa 1373281 gtggaacggc tgttttctga aacaaagacg ctgctgtatt cagatatacc cgatcatgag 1373341 acgctgaaac tgattcaaag gcatgttcaa aaaggggaca ttgacgtgac gtataaagtc 1373401 gcgcaaaaaa ccaataaaaa aatggtcagg catattcagg caaatgcgag taaagaagag 1373461 cttgctaagc aggctgaggg attgtcccgc caagcagcaa aacagcaggc gattcttcac 1373521 tttctcatct ctgagccgga aggtgtgaaa attcctgcgg cggaattgtg caaaaaaacg 1373581 gacacgagct ctgcaaccat caaaaccctt atccaaaaag ggcttttgaa ggaaagctat 1373641 gaagaggttt acagagatcc ctatcaggac aaaatgttca aaaaaacaga gcccctgccg 1373701 ctgacagacg aacagagggc tgccttcgag cccatacgcg agacattgga cagcgatgag 1373761 cataaagtgt tcctccttca cggcgtgaca ggaagcggaa aaaccgaaat ttatctgcaa 1373821 tcaattgaaa aagtactggc gaaaggaaaa gaagccatcg tcctcgtacc ggaaatatcg 1373881 ctgacgccgc aaatggtcaa ccgcttcaag ggccgcttcg gctcccaggt ggcagtcatg 1373941 cacagcggtt tatccacagg agaaaaatat gacgagtggc gtaaaatcca ccggaaggaa 1374001 gtacggcttg tcgtcggtgc cagatccgcc atttttgctc cgtttgaaaa tctcggaatg 1374061 ataatcatcg atgaagagca cgagtcttcc tataaacagg aagaaatgcc gcgctatcat 1374121 gcgaaagagg tggcaatcaa gcgggctgag catcacagct gcccggttgt attagggagt 1374181 gctacgccga cattagaatc atatgctaga gcgcaaaagg gcgtatacga gcttctttca 1374241 ctgaagcacc gtgttaacca tcgggtgatg cccgaggttt cgcttgtcga tatgagagag 1374301 gagcttagaa acggcaatcg ctcgatgttt tcagttgaat tgatggaaaa gcttgaagaa 1374361 acgattgcca agggtgagca ggcggtgctg tttttaaata agaggggcta ctcttccttt 1374421 gtgatgtgca gggattgcgg ctatgtcccg caatgcccgc actgcgacat ttccatgacg 1374481 tatcatcgtt acggccaaag gctgaaatgc cattattgcg gacatgaaga gcctgttccg 1374541 cacacttgtc ctgaatgcgc aagcgagcat atccgctttt tcggaacggg aacacagcga 1374601 gtggaggaag agctgacaaa agtgctgcca agtgcgagag tgattcggat ggatgttgac 1374661 acgacatcac ggaaaggcgc ccatgaaaaa ttactgtcag ctttcggaga aggaaaagcg 1374721 gatattcttc tcggaacgca aatgatcgcg aaagggcttg attttccgaa tgtcacgctt 1374781 gtcggagtgt taagtgctga tacaacactt catattcctg atttcagatc ggctgaaaaa 1374841 acatttcagc tgttaacgca agtcagcggc cgggcaggca ggcatgaaaa gcccggccat 1374901 gtcatcattc aaacgtatac accgtctcat tacagtatcc agctgacgaa aacacacgat 1374961 tatgaaacgt tctatcagca tgaaatggcg cacaggagag agcaatccta tccgccatac 1375021 tactatttgg ctcttgtgac tgtttctcat gaggaagtgg cgaaagcagc ggttacagct 1375081 gaaaaaatcg ctcatttttt gaaagcaaac tgcggagctg acacgaaaat tctcggacca 1375141 agcgcgtcgc cgatagccag gatcaaagat agatatcgct atcaatgcgt gataaaatac 1375201 aaacaggaaa cccagttatc cgctttattg aagaagatac tggaacatta taaacgcgaa 1375261 attgaacaaa aacatgtaat gatttcaatt gatatgaatc cttatatgat gatgtaagat 1375321 ctcacgtctt ggagggtaac aaattggcag taaaaaaggt cgtcacacat cctgcggagg 1375381 ttttggaaac acctgcggaa accgtgactg tttttgataa aaagctaaaa aaactgcttg 1375441 atgatatgta cgacaccatg cttgaaatgg atggtgtcgg actggcagcg ccgcaaatcg 1375501 gcattttaaa aagagcggcc gtcgtagaaa tcggggatga cagagggaga attgatctcg 1375561 ttaatcctga aattttagaa aaaagcggcg agcaaaccgg aattgaagga tgcttgagct 1375621 ttcctaacgt ctatggtgat gtcacacgtg ccgattatgt caaagtgcgt gcgtttaacc 1375681 gtcagggaaa accgttcatt ctggaagcgc gaggcttttt agcaagagcc gtgcagcatg 1375741 aaatggacca cttagacggt gtgctgttta catctaaaat aagtaaatac tatacagaag 1375801 atgaactagc ggatatggaa ggatgatttg atgacgagaa tcgtatttat gggaacgccg 1375861 gatttttcag ttcctgtttt aagaaccctg atagaggacg gatatgaagt agtgggggtc 1375921 gtcacacagc cggaccgtcc gaagggcaga aaaaaagtac tgacacctcc tccggtaaag 1375981 gaagaggcat tgcgccacgg catcccggtt cttcagccgg aaaaagtcag attgacagaa 1376041 gaaattgaaa aagtgctggc attaaagcct gacctgattg taacggcggc attcggacaa 1376101 attttgccta aagagcttct cgacagtcca aaatacggct gcattaacgt tcacgcatcc 1376161 cttttgccgg aactgcgcgg cggtgctccg atccattatt ccattctgca gggaaagaag 1376221 aaaaccggga ttaccattat gtatatggta gaaaaattgg atgcgggcga tatgatctca 1376281 aaagtggaag tggacattga agaaaccgac aatgtcggaa cactgcacga taaattaagc 1376341 gttgctggcg cgaagctatt gtctgaaacg gttccaaacg ttattgccgg cagcatatca 1376401 cctgaaaagc aggatgaaga gaaagcgacg tacgcgccta acattaaaag agagcaagag 1376461 ctgctcgact ggtccagaac gggcgaagag ctttacaacc agatccgcgg cttaaatcca 1376521 tggcctgttg cttatacgac tctaaacgga caaaacttga aaatatgggc gtcgaaaaaa 1376581 atagcggcac caacaacagc tgagcccggc acagtcgttg cagttgaaaa ggaaggaatt 1376641 atcgttgcca caggtaacga gacggctctg ttattaaccg aactccagcc ggcaggcaaa 1376701 aaacgaatga aaggcgaaga ctttgtgcga ggcgctcatg ttgaagccgg tgatgtgtta 1376761 ggagtaaaca atgaaaaaaa ctagtgttcg tgacatcgcc cttgaggcgc tgatcaaatt 1376821 agaacaaaac caggcataca gcaacctgct gctgaaatcg gtcattaaat caaatgaact 1376881 gagtgatcag aacagagggc ttttgactga acttgtctat ggtacattac aaaataagat 1376941 cgcgcttgat tatatgctta aaccgtttat caataagcct caaaaggtaa agccgtgggt 1377001 gattcagctt cttcgcctat ccttatatca aatggagtat ttggagaaga ttccagacag 1377061 ggcagccatt catgaagcgg ttgagattgc taaaatccgc ggacacaaag gcattgcttc 1377121 atttgtcaac ggcgtgctcc gttctattca gcgcgaaggt gttccatcct ttgacgcgat 1377181 cgaagatcct gtccgccggc tggcgacaga aacaagccat ccggaatggc ttgtgaaaga 1377241 gtgggcggat gcgtatggat ttgaagctgc ggaaaagatt tgccgcatcc atctcattcc 1377301 gccgaaacag acgctgcgtg tcaatcaaat gaaagcagac agagctgagc tgcttgacca 1377361 aatggctgct gagggaatcg aagttgaaaa aggcgacctc gctgaagatg ctgtgaagct 1377421 cttaaaggga acaattgccg gaactcattt cttccaaaac ggcgaagttt ctatccagga 1377481 tgagagctcc atgctcgtcg cccgcgccct tgatcctaag tcagatgaaa cagtgcttga 1377541 cgcgtgtgcg gcgcctggcg gaaagtcggc tcatatcgca gaattaatga agaacaaggg 1377601 gagcgttacg tcgcttgatc ttcacaaaca taaagtgaag ctgatcaaag aagcggcaga 1377661 tcggcttggc ctgacaatca ttcatgcgga aacaatggat gctagaaaag cgggggaaac 1377721 gtttgaaaac gaacagtttg accgaatatt ggtcgatgcc ccgtgctcag gtttcggtgt 1377781 tatcagaaga aagccggaca tgaaatacac gaaaaaacct gacgacagcg cccgtctagc 1377841 tgaaatccag ctgtcgatct tgagggaaat cgcaccatta gtaaaaaaag gtggcactct 1377901 tgtctacagt acgtgtacaa tggaccggac agaaaatgat gaagtaatac atgcgtttat 1377961 acaagaacat cctgattttg aacccgattt gtctcttgaa aagcggctgc ctgaaaaggt 1378021 gagacccttt gttcgggatg gaaggcttca aatccttcct cattatttcg gaacagatgg 1378081 tttctttatt tgcagcatga gaaagaaggg ataagcaatg gcagaactta ataaaacaaa 1378141 agtaagaaaa gaattgcgga cagagcgtcc gtctatttat tcttttgaat tagatgaaat 1378201 caaacaatgg ctgacagaca atggagagaa accgttccgt gcagcccaga tctttgaatg 1378261 gctatatgaa aaacgcgtat cttcttttga agatatgaca aacctctcaa aggatctgcg 1378321 tgagaaatta aacactcgct ttgtgttaac aacgctgaaa acggctgtta aacaaacctc 1378381 tcaagacggt acgatgaagt ttttgtttga gcttcatgac ggttatacca tcgaaaccgt 1378441 tttaatgaga cacgagtatg gcaattctgt atgtgtaacg acacaagtcg gctgccgtat 1378501 tggctgcaca ttctgcgcgt caacgcttgg aggcttaaaa cgaaaccttg aagcagggga 1378561 aattgtcgct caagtagtca aagtgcaaaa agctcttgat gaaacggatg aacgcgtcag 1378621 ctctgtcgtg atcatgggaa tcggcgaacc ttttgataac tttaacgaaa tgctcgcttt 1378681 cttgaaaatc attaaccatg acaagggcct gaatatcggt gctcgccata ttacggtctc 1378741 tacgagtgga atcatcccga aaatttacga atttgctgat cagcaaatgc agattaactt 1378801 tgcaatttct ctgcacgcgc cgaacacaga aatcagaagc cgtttgatgc cgattaacag 1378861 agcatataaa ctgcctgatc taatggaagc cgttaaatat tatattaata aaacaggacg 1378921 ccgtatcagc tttgaatacg ggctgttcgg aggcgtaaac gaccaggtgg aacacgccga 1378981 agagcttgcc gacttgctgg aaggagtcaa atgccacgtg aacttgattc cggtaaacta 1379041 cgtgcctgaa cgggactatg tgcgcacacc gcgtgatcag atttttgctt ttgaaaaaac 1379101 gctgaaatcc cgcggagtaa atgtcacaat ccgaagagag caaggacatg acattgacgc 1379161 agcctgcggt cagcttcgcg cgaaggagcg tcaagacgag acgaggtgat gagggttgtt 1379221 aacagcctta aaaacagata caggaaaaat ccgccagcat aatgaagatg atgcggggat 1379281 attcaagggg aaagatgaat ttatattagc ggttgtcgct gatggcatgg gcggccatct 1379341 tgctggagat gttgcgagca agatggctgt gaaagccatg ggggagaaat ggaatgaagc 1379401 agagacgatt ccaactgcgc cctcggaatg tgaaaaatgg ctcattgaac agattctatc 1379461 ggtaaacagc aaaatatacg atcacgctca agcccacgaa gaatgccaag gcatggggac 1379521 gacgattgta tgtgcacttt ttacggggaa aacggtttct gttgcccata tcggagacag 1379581 cagatgctat ttgcttcagg acgatgattt cgttcaagtg acagaagacc attcgcttgt 1379641 aaatgaactg gttcgcactg gagagatttc cagagaagac gctgaacatc atccgcgaaa 1379701 aaatgtgttg acgaaggcgc ttggaacaga ccagttagtc agtattgaca cccgttcctt 1379761 tgatatagaa cccggagaca aactgcttct atgttctgac ggactgacaa ataaagtgga 1379821 aggcactgag ttaaaagaca tcctgcaaag cgattcagct cctcaggaaa aagtaaacct 1379881 gcttgtggac aaagccaatc agaatggcgg agaagacaac attacagcag ttttgcttga 1379941 gcttgcttta caagttgaag agggtgaaga tcagtgctaa tcggcaagcg gatcagcggg 1380001 cgttaccaaa ttctccgcgt cataggcggc gggggaatgg ccaacgtgta tttagctgag 1380061 gatatcattc tagaccgtga agtcgcaatt aaaatcctgc ggtttgacta tgcaaatgac 1380121 aatgaattta tcagacgttt ccgcagagaa gcccaatccg catcaagcct cgatcacccg 1380181 aatattgtca gcatttatga tttgggcgag gaagatgata tttattatat tgtcatggaa 1380241 tacgttgaag gcatgacgct taaagaatac ataacagcaa atgggccgct tcaccctaaa 1380301 gaagcgctga acatcatgga gcaaattgtc tcagccatcg ctcatgccca tcaaaaccag 1380361 attgttcaca gagacatcaa gccgcataac attttgattg atcatatggg aaatatcaaa 1380421 gtaacggatt ttggaattgc gacggcacta agttcgacca caatcaccca taccaattca 1380481 gttctgggct cggtccatta cttatcacct gaacaggccc ggggcggctt agccacaaaa 1380541 aaatcggata tttatgcgct tggaatcgtt ctatttgagc ttttaaccgg ccgtattccg 1380601 tttgatggag agtcagcagt cagcatcgcc ttgaagcatc ttcaagcgga aactccttcg 1380661 gcaaaaaggt ggaatccatc ggtcccccaa agcgttgaaa acatcatact caaggcaact 1380721 gccaaagatc cttttcatcg ctacgaaacg gctgaagaca tggaagcaga cataaaaaca 1380781 gcttttgatg ccgacagact caatgaaaag agatttacga ttcaagaaga tgaagaaatg 1380841 acaaaagcga tacctatcat taaagatgaa gaacttgcta aagctgctgg cgaaaaagaa 1380901 gctgaagtga caaccgcaca agaaaacaaa acaaagaaga acggcaaaag aaaaaagtgg 1380961 ccgtgggttt tgctcacgat atgcctcgtt tttatcacag ctggaattct tgctgtcact 1381021 gtttttccgt cgcttttcat gcctaaggat gtcaaaatac ctgatgtctc cggaatggaa 1381081 tacgaaaaag ccgcagggct cttggaaaaa gaaggtttac aggttgattc cgaggtgttg 1381141 gaaatctcag atgaaaaaat tgaagagggc ctgatggtaa aaacggatcc taaagcggat 1381201 accacagtca aagaaggcgc cacggtcacc ctttataaga gcaccggaaa agcaaaaacg 1381261 gagatcggtg atgtgacagg ccaaacggtc gaccaagcaa aaaaagcgtt gaaggaccaa 1381321 gggtttaatc atgtaacagt aaatgaagtg aatgacgaga aaaatgcggg cactgtcatt 1381381 gaccaaaatc cttcagcagg gactgagctg gtcccgagtg aagatcaagt caaacttaca 1381441 gtcagtatcg gacccgaaga cattacgctt agagacttga aaacctacag taaagaagca 1381501 gcgtctggat atctggaaga caacggattg aagcttgtag aaaaagaagc atactcagat 1381561 gatgttccag aaggacaggt tgtcaaacaa aaaccagcag caggtacggc agtaaagccg 1381621 ggaaacgaag ttgaagtgac attctctctc ggaccagaga aaaaacctgc gaaaacagtg 1381681 aaagaaaagg tcaagatccc ctacgaacca gaaaatgaag gggacgagct tcaagtgcaa 1381741 atcgcggttg acgatgcgga tcacagcatc tctgacactt acgaagaatt taagataaaa 1381801 gagccgactg aacgaacgat cgaactaaag attgaaccag gccaaaaagg gtactatcaa 1381861 gtaatggtaa acaataaagt tgtcagctac aaaaccattg agtatccgaa agatgaataa 1381921 caaggaggga aaatatgcct gagggcaaaa ttattaaggc gctaagcggc ttttactatg 1381981 tactggatga atcagaggat tcagataaag taatacaatg cagaggaaga ggcattttca 1382041 gaaaaaacaa aattacccct cttgtcggtg attacgttgt gtatcaagct gaaaatgaca 1382101 aagaaggata tctaatggaa attaaagaaa gaaccaacga gcttatcagg ccgccaattt 1382161 gcaacgttga tcaagcggtc cttgttttct cagcggttca gccttctttc agcacggcat 1382221 tgctcgaccg cttcctggtt ctcgttgagg ccaatgatat tcagccgatt atatgcatta 1382281 ctaaaatgga tctgattgaa gatcaagata cagaagatac gatacaagcc tatgcagaag 1382341 actatcggaa tattggttat gacgtatacc ttacctcctc taaggaccaa gatagtttag 1382401 cggacatcat cccgcatttt caggataaaa caacggtatt tgccggtcag tccggtgttg 1382461 ggaaatcctc gcttctcaac gcgatcagtc cggagctcgg attaagaaca aacgagattt 1382521 ccgagcattt gggccgcggg aaacacacaa cccgccacgt ggagctgatt cacacgtccg 1382581 gaggtttggt tgcagataca ccgggattca gctcgcttga atttacagac attgaggaag 1382641 aagagctggg ctataccttc cctgatatca gagaaaaaag ctcttcatgc aaatttagag 1382701 gctgtttaca tctgaaagag ccgaaatgtg cggtgaaaca agctgttgaa gacggggaat 1382761 taaagcagta tcgctatgac cattatgttg aatttatgac ggagattaaa gacagaaagc 1382821 cgaggtatta gcataatgat aaaggttgca ccatctattc tttccgctga ttttgccgct 1382881 ttaggcaatg agattaaaga tgtagaaaaa ggcggagccg attgtattca tattgatgtt 1382941 atggacggcc attttgtccc gaatatcaca atcggtccgc tgattgtaga agcggtccgg 1383001 ccggtaacgg atctgccgct tgatgtccat ttaatgatag aagagccgga tcgttatatc 1383061 ccggcttttg cgaaagcagg cgcagatatc ctgtctgtgc atgctgaggc atgtccgcac 1383121 ctgcaccgta ccatccagct cattaaagag caaggagtga aggccggagt agttctaaac 1383181 ccgcataccc ctgtacaagt catcgaacat gttttcgacg atcttgatct tgttctttta 1383241 atgacggtga acccgggctt cggcgggcag aaatttattc attcagtcct tcctaaaata 1383301 aaagaggtta agcgaatggc ggatgaaaaa ggaaaaaaag atctgttaat tgaagtagac 1383361 ggcggcgtca acaaagaaac cgctccgctc gtcattgaag cgggcgcaaa tttactcgtt 1383421 gccggttcag ctgtttatgg ccagtctgac cgcaaaaaag caatttctga aatcagagga 1383481 agtaaataag cagctttaga aaagagctgg gcatacaata gcctaagctc tttttcctgt 1383541 atgcagagaa aggaatcaga gatgaaaaca attaatatcg ttgcgggagg cccgaaaaat 1383601 ctcattcccg atctaaccgg ctatacggat gaacacacgc tttggatcgg tgttgacaaa 1383661 ggcaccgtca ctctcttaga tgccgggatc attcctgttg aagccttcgg agattttgac 1383721 agcataacgg agcaagaacg ccggcgaata gaaaaagccg ctcccgccct tcatgtgtat 1383781 caagcagaaa aagatcaaac agatttagac ctcgcccttg attgggcgct ggaaaagcag 1383841 ccggatatta ttcagatttt cggcattaca ggcggcagag ctgatcattt tttaggaaac 1383901 attcagcttc tgtataaagg tgtaaaaacg aacataaaaa ttaggctgat agacaaacaa 1383961 aatcatattc aaatgttccc tcctggtgaa tatgatattg agaaggatga aaataagcga 1384021 tatatctcct tcataccgtt ttccgaagac atacatgagc tgaccctgac cggttttaaa 1384081 tatcctctaa ataattgtca tattacgctc ggttcaacac tatgtattag taacgaactc 1384141 attcattcac gaggtacttt ttcgtttgca aaaggcatat taataatgat aagaagcacg 1384201 gattaagcat gtgctttcat tcaattgctg aaaacaatga acaaggcggt tacgggacgt 1384261 tataggaggg gacaaaaatg aaattttaca ccattaaatt gccgaagttt ttaggaggaa 1384321 ttgtccgggc gatgctgggc tcatttagaa aagattaatg cccaggggtt caaagccctc 1384381 tttcaccaca taaaaacgcc tgccacatat cggggcaggc gttcattttg ttatacacgc 1384441 tcaactttac cggatttcaa agctcgagca gatacatata cttttttagg ttttccgttc 1384501 acaaggatac gaaccttttg aagattcgcg ccccaagtgc gcttagaagc gttcattgcg 1384561 tgagaacggt tattcccagc tgttgttttt ttacctgtga taacgcattt acgtgccatt 1384621 tgtttccctc ctcacttgca caaaacatct actttttaac attcatataa tcttagatgc 1384681 tttcgatatg gatactttaa ataatttacc acagctaaaa aacgtttgca actattgttt 1384741 catcatcttt caagaaaatt cacttgacat cttgcggaaa cagcagcgct atagtatatg 1384801 tagaggtacg gccagcgatt attgcctggt cttttcataa tggaaaccat atagtagaat 1384861 agctgtaact ctatgcattc gaaggaggaa ctagtgtgtc cattgaatta agaacgaagt 1384921 acggacagat tgatatatct aatgaagtca tcgcgatggt tgcaggaggc gcggcggttg 1384981 actgttacgg cattgtcggc atggcctcta aaaaccagat taaagacgga ctgactgaaa 1385041 tccttcggaa agagaatttc agcaggggtg tccaagttcg ccaagaagga gaacagatac 1385101 atatcgacat gtatatcatt gtcagctacg gcacgaaaat ttctgaagtg gcacataatg 1385161 tccaaacaaa agtaaagtac acagtaaatc aaaccatcgg actggcagtg gattctgtca 1385221 atatttatgt ccaaggcgta cgagtgacga acccgtagtt aggaggagta ggattgtcta 1385281 tcagaacatt agacggcaga acctttgccg agatgattct tgcgggagcg cagaatctgt 1385341 ctcaaaacgc cagtgcagtt gatgcactga acgtgttccc ggtgccggac ggtgatacgg 1385401 gaacaaatat gaacctgtcg atgacttccg gagcaagaga agttgaacaa atggatacgg 1385461 atgatatcgg gaaggtgggc tccgcgttat ctaaagggct gctcatggga gcacgcggaa 1385521 attcaggagt tatcctatcc caattgttcc gcggatttag caaaaacatt gaaacgaaaa 1385581 aagaaattaa tgcacttgag tttgccgctg cgctgcaagc aggtgtagac atggcgtata 1385641 aagctgtcat gaaacctgta gagggcacca ttttaacagt tgcaaaagac gctgcaaaaa 1385701 aagcaatgat cttagcagaa aaagaaaccg atatcactgc gctgatgact gcagtgacag 1385761 aagaagcaga ggcgtcttta aaccgcaccc ctgaattgct acctgtccta aaggaagtag 1385821 gagttgtcga tagcgggggc aaaggcctgc tctgtgtgta tgaaggtttc cttgcttcat 1385881 taaaaggtga aactgtacct cagaaagcag ttcttccgtc acttgacgac atggtcagcg 1385941 cagagcatca caagagcgcg caaagcatga tgaataccga agatattgaa tttggattct 1386001 gtaccgaagt gatggttagg cttgatcaga caaaaagaga gttcgacgaa ggcacgttca 1386061 ggcaagacct cagccagttc ggagattctc tgcttgtgat tgcggatgaa tcgctggcga 1386121 aggttcatat tcatgctgaa gagccgggaa acgtgttaaa ctacgcccag cattacggtg 1386181 aattgatcaa aataaaaata gaaaatatga gagaacagca tacctctatc atcagtcaag 1386241 aaagcaaacc tgcagacaac gaaacaccgc cggcaaaaca gccgtatggc attgtgactg 1386301 tagcgatggg agaaggaatt gcagacctat ttaaaagcat tggcgcttct gttgtgattg 1386361 aaggcggcca gaccatgaac ccaagcactg aggatattgt tgatgccgtg aagtctgtaa 1386421 atgcagatac ggtatttatc ctgcctaaca actccaacat tatcatggct gctaaccaag 1386481 cggccagcgt agtggatgaa caggtttttg tcattcctgc taaaacggtt ccgcaaggga 1386541 tgtcagctct gctggctttt aacccggatc aagaagctga agcgaacgag gccaatatgc 1386601 taagcgccat tcagcaagta aaaagcggac aggtgacgtt ctcagtcaga gatactcata 1386661 ttgacggtaa agacattaaa aaaggcgact ttatgggcat tctgaatgga acgattatcg 1386721 gcacttctga aaatcagctg tcagccgcga aaatgctgct gtcagaaatg atcggagaag 1386781 atgatgaaat cgtgaccatt ctatatggtg aggatgcgtc tcaggaagaa gctgagcagc 1386841 ttgaagcgtt tctcagtgaa aagtacgagg agattgaggt tgagatccac aatgggaaac 1386901 agcctctgta ttcgtatata gtttcagcag aatagaaggg caatttgccc ttctattctt 1386961 atgtctgctt ttaagtgcgg cagcgctgta acgcgcccgc ttgccatttt atatctgatc 1387021 aattagtcta gaagcaaagc gctaataagc tctggttcat aaggaggaat agcatgaaat 1387081 acagaagcgt ttttgatatt atcggcccgg ttatgatcgg tccgtccagc tctcatacag 1387141 cgggagctgc tagaatcggg agagtggcca gaagtttatt tggcagagag cctgagcgca 1387201 tcattgtatc tttttacggc tcgtttgcgg aaacgtataa gggccacggc acagatgtcg 1387261 cgattatcgg cggattgctt gattttgata cattcgatga acggattaaa accgctatac 1387321 aaattgcaga agctaaagga attgatatag agtttcgggt agaagacgca gtcccggtcc 1387381 acccgaacac agcaaaaatc accatttctg atgaaaaggg tgagctggaa ctgacgggta 1387441 tttcgattgg cggaggaaag attgaaatca cagaattgaa tggttttgag ctccggctgt 1387501 caggaaatca tccggccata ttagttgttc ataatgacaa gtttggcaca attgccggtg 1387561 ttgccaatgt tctggcgaaa ttttcaatca acgtaggaca tatggaagta gcccggaaag 1387621 atatcggcca gcttgcgctg atgacaatag aggtcgatca aaatattgac gaccacattc 1387681 tcgacgagct gtcgaagctg ccgaatatta ttcaagtgac aaagattgct gactagcgaa 1387741 aagggtcagg aggagccagt tatgtttcgt aatgtaaaag aattaattga gattactaaa 1387801 gaaaaacaaa tattgatctc tgatgtgatg atagctcaag agatggaagt aacagaaaaa 1387861 acaaaagagg acatttttca gcagatggat cataacctgt ctgttatgga agcggcggtt 1387921 cagaaaggac tcgagggagt tacgagccaa acgggcttaa caggcggaga tgccgttaaa 1387981 ttgcaggcct atattcgatc aggaaaaagc ctgtctggcc cgctgatttt agatgctgta 1388041 tcgaaagccg ttgcaacaaa tgaagtaaat gcagccatgg gaaccatctg tgcgacaccg 1388101 actgcaggtt ctgccggtgt ggtgcccggt acgttatttg ctgtaaaaga aaagctgaat 1388161 ccaacaagag aacaaatgat ccgctttttg tttacagccg gggctttcgg atttgtcgtg 1388221 gccaataacg caagcatttc cggcgccgcc ggaggatgtc aggcagaggt tggatcagct 1388281 tcaggcatgg cggctgcggc tattgttgaa atggcaggag gaacacccga acaaagcgcg 1388341 gaagccatgg ccattacatt aaaaaatatg ctaggcctcg tgtgcgaccc tgttgcaggg 1388401 cttgttgagg tgccttgcgt gaaacggaat gcgatgggcg cgtcaaatgc gatgattgct 1388461 gctgatatgg cattggcggg cattacaagc cgtattccat gtgatgaggt tatcgatgcc 1388521 atgtataaaa taggccaaac gatgccaact gcacttagag aaacaggcca gggcggttta 1388581 gcggcaacac cgacaggaag agaattagag aaaaaaattt tcggaggagc gctaggttca 1388641 cgtgaaacaa catcagcaaa ctagtatagc taacattaag ggtattgggc cggaaacaga 1388701 aaaaacattg aatgaactcg gtatttatga catttctgat cttctgaatt atttccctta 1388761 tcgctatgat gactacgagc tgagggattt agaagaagta aagcatgatg aaagagtcac 1388821 agtcgaaggg aaggttcatt cagagccttc tcttacctat tacggaaaaa aacgaaacag 1388881 gctgacattc aggcttctgg tcggccacta tttaatcaca gccgtatgtt ttaaccggcc 1388941 ttatttgaag aagaagcttt cgctcggctc tgtggtgacg gtttcaggta aatgggacaa 1389001 gcaccgccaa accatctctg ttcaggagtt gaaaaacggg ccgcatcaag aagacaaaag 1389061 cattgaacca gtgtattctg tgaaagaaaa tgttaccgtc aaaatgatga ggcgctttat 1389121 tcagcaggcg ctgacccaat atgcagactc acttcctgat cctcttccgg aaaagctaag 1389181 aaaaagctat aaactgcctg actattatca agcgttaaaa gcaatgcacc agcctgaaac 1389241 aagggaagca ttaaagcttg ccagacggcg gtttgtttat gaagaatttt tgttgtttca 1389301 gttgaaaatg caggcgttcc gaaaggcgga aagagagcag acacaaggga tacggcagcg 1389361 tttttcaaac gaagaactca tgagatttat caaaagcctc ccgtttcccc tcacaaacgc 1389421 ccagtcacgc gttcttcgcg aaataacagc agacatgtct tctccataca gaatgaaccg 1389481 tcttcttcaa ggggacgttg gatcaggaaa aacggcagtc gccgccattg cactgtatgc 1389541 cgcgatccta tccggatacc aaggagcgct catggtgccg acagaaattc tggccgagca 1389601 gcatgctgat tcgctcgttt cgctatttga aaaatgggac gtcagcgttg ctcttttgac 1389661 aagctctgtt aaaggaaagc ggcgaaaaga actgcttgag cgtcttgcgg cgggtgagat 1389721 tgatattctt gtaggaaccc atgctttaat ccaagacgag gtggagttta aggcgttgag 1389781 tctcgttatt actgatgaac agcacagatt tggagttgag cagcgcaaaa agcttcggaa 1389841 caaagggcag gatcccgatg ttctctttat gacagccact ccaatcccaa gaacattagc 1389901 gatcacagta ttcggtgaaa tggatgtatc tgtcattgat gagatgccgg ctggacgaaa 1389961 gcgaattgaa acctattggg taaaacatga catgcttgat cgtattttgg catttgtcga 1390021 aaaagaatta aagcaaggca ggcaggctta tatcatctgt ccgctgattg aagaatcaga 1390081 taagcttgat gtgcaaaacg ccattgacgt gtacaatatg ctttctgata tttttcgggg 1390141 aaaatggaat gtcggcctta tgcatggaaa gctgcattcc gatgaaaaag atcaggtcat 1390201 gagagaattc agcgcaaatc actgtcaaat tctcgtatca accactgttg tggaggttgg 1390261 cgtaaatgtt ccgaatgcaa caattatggt gatttatgac gccgaccgtt tcggactatc 1390321 acagcttcac cagctgcgcg gccgtgttgg acggggtgag catcaatctt tctgtattct 1390381 gatggctgat ccaaaatcag aaacagggaa agaacggatg aggatcatgt cggagaccaa 1390441 tgacggtttc gagctgtctg aaaaggatct ggaactgaga ggtcccggtg atttcttcgg 1390501 gaaaaaacaa agcggaatgc cggaatttaa agtggcggac atggttcatg attacagagc 1390561 gcttgaaacg gcaaggcagg atgctgcgaa tcttgtggct tctgacgcgt tctggaagga 1390621 gccggaatac gctgtgttaa gagatgaatt gctgaagagc ggagtaatgg acggggaaaa 1390681 attaagctga gtatcagaag tttttggtgt tcagccagaa acaatcgttg cattccaatc 1390741 tatgaaatta tatactacta ttagtaccta gtcttaattg tccggatggt gtttagatat 1390801 gagaagaaat aagagagaac gccaggaatt acttcagcag acgattcaag caaccccctt 1390861 tattacagat gaagaactag cgggtaaatt cggggtgagc atccagacga tacgtttgga 1390921 ccgcttagag ctttccatac ctgaactgag agaaagaatt aagaacgtgg cagagaaaac 1390981 acttgaggac gaagtgaagt ccctgtcact tgatgaagtt atcggagaaa ttattgacct 1391041 tgagctggat gatcaggcga tatccatttt agaaataaaa caggagcacg tgttcagccg 1391101 gaatcagatt gcgagaggac accatttatt tgcacaggcg aattctttgg ccgttgcagt 1391161 cattgatgac gagctggcgc tgactgcaag tgcagacatc cgctttacaa gacaggtaaa 1391221 gcagggtgaa cgtgtcgtag caaaagcgaa agtgacggct gtcgaaaaag aaaaaggaag 1391281 aacggttgtc gaagtgaaca gctacgttgg cgaagaaatt gttttttctg gacgctttga 1391341 catgtatcgt tcaaaacatt cataaaggtg gagcatgcat gagaatagct gtagatgcaa 1391401 tgggaggaga ccacgctccc aaagctgtta ttgacggagt tataaaaggt atagaggcat 1391461 ttgatgatct ccatatcaca cttgtcggtg acaaaacaac gatagaatca catttaacaa 1391521 ctacatcaga tcgcatcacg gtgctgcacg cagatgaagt gattgagcct acggatgaac 1391581 cggtccgtgc cgtgcgaaga aaaaagaact catctatggt tcttatggcg caggaggttg 1391641 cggaaaacag agctgacgcc tgcatttcag cgggaaatac cggtgcatta atgacagccg 1391701 gtctctttat tgtcgggaga attaaaggaa ttgaccgtcc ggcgcttgct ccgacacttc 1391761 cgactgtttc gggagacgga tttcttctcc ttgatgtcgg cgccaatgtc gatgccaaac 1391821 cggagcacct cgttcaatat gccatcatgg gttctgttta ttctcagcaa gtgcgcggtg 1391881 tcacttcacc gagagtcgga cttttaaatg tcggaacaga agataaaaaa ggaaacgaac 1391941 tgacgaagca gacgtttcaa attttaaaag aaacagcaaa catcaatttt atcggaaacg 1392001 tggaagcgcg agacctttta gatgatgtgg cggatgttgt agtaacagac ggctttaccg 1392061 ggaatgttac actcaaaacg ctggaaggct ctgcgttgtc aatttttaaa atgatgagag 1392121 acgtaatgac gtctactttg acatccaagc ttgcagcagc tgtgctgaaa ccaaaattga 1392181 aagaaatgaa aatgaaaatg gagtattcga attatggcgg agcaagtctt tttggcttaa 1392241 aagcgcctgt gatcaaggcg cacggctctt cagattcaaa tgctgtattc catgcgattc 1392301 ggcaagcaag agagatggtc agccaaaatg tggctgcgct cattcaggaa gaagtgaaag 1392361 aagaaaaaac agatgagtag tctggaggtt tttacatcat gagtaagatt gcatttttat 1392421 tcccgggtca gggatcacaa tttatcggca tgggaaaaga gctttatgag caggtgcctg 1392481 ctgcaaagcg tctgtttgat gaagccgatg aaacgttgga aacaaaactc agctcgctta 1392541 tttttgaggg ggatgctgaa gaattaacac ttacatacaa tgcgcagcct gctttgctta 1392601 cgacaagcat cgctgttctt gagaaattta aagaatctgg cattacacct gatttcacag 1392661 caggacacag ccttggtgaa tattctgcac tggttgcggc tggcgctctg tctttcaaag 1392721 atgctgttta tactgtcaga aagcgcggag agtttatgaa tgaagcggtg ccggctggcg 1392781 aaggagcaat ggctgcgatt ctcggcatgg atgctgaagc attaaagcaa gtaaccgata 1392841 aagtcacaga ggaaggcaac cttgtacagc ttgcgaatct caactgtcct ggccaaatcg 1392901 tcatttccgg aacagctaaa ggggttgagc ttgcatctga actggcaaaa gagaacggcg 1392961 caaaacgcgc aattccgctt gaagtaagcg gtccgttcca ttctgaactg atgaaaccgg 1393021 ctgctgaaaa gctgaaagag gtattggacg cctgtgacat aaaagacgct gacgttccgg 1393081 tcatctcaaa tgtttctgct gacgtgatga ctgaaaaagc agatatcaaa gaaaaactta 1393141 ttgagcagct ttactctccg gttcgttttg aggaaagcat taacaagctg atcgcagagg 1393201 gtgttacgac ttttattgaa atcggtcccg gaaaagtgct ttcaggcctt gtgaaaaaag 1393261 tgaatagacg gttaaaaaca attgctgtat cagatccgga aacgatcgag ctggcaattc 1393321 aaacgcttaa ggaggagaat gataatgctt aatgataaaa cggctattgt cactggcgca 1393381 tcccgcggaa tcggccgctc aatcgccctt gatctggcaa aaagcggagc aaatgttgtc 1393441 gtgaactact ccggcaatga agcgaaagca aatgaagtgg tagatgaaat caaatcaatg 1393501 ggcagaaaag caattgctgt aaaagcggat gtatcaaatc ccgaagatgt acaaaacatg 1393561 ataaaagaaa cattgtctgt tttttctacg attgacattc tggttaataa tgcgggaatt 1393621 acaagagaca atctcatcat gagaatgaaa gaagacgaat gggatgacgt cattaacatt 1393681 aacctgaagg gtgttttcaa ctgcacaaaa gctgttacaa gacaaatgat gaaacagcgt 1393741 tcaggccgca ttattaacgt atcgtctatc gtcggcgtca gcggaaaccc tggacaagcc 1393801 aactacgtgg ctgcaaaagc cggcgtcatc ggtttaacca aatcttctgc taaagagctc 1393861 gccagccgaa atattacggt aaacgcaata gcgccaggat ttatctcaac tgatatgaca 1393921 gataaacttg caaaagacgt tcaagacgaa atgctgaaac aaattccgct cgcgcgcttt 1393981 ggtgaaccta gcgatgtcag cagtgttgtc acgttcctag cttcagaggg agctcgttat 1394041 atgacaggcc aaacgcttca tattgacggc ggaatggtga tgtaagtttt ttctcgaaaa 1394101 tttcatcgta gtttctctag ttttttaaaa acgaatccac tataatactt gaggggaggt 1394161 gaattgctat ggcagacaca ttagagcgtg taacgaaaat catcgtagat cgccttggcg 1394221 ttgatgaagc agacgtcaaa cttgaagctt ctttcaagga agacttaggt gctgattccc 1394281 tagatgtagt tgagcttgtt atggaacttg aagacgagtt tgatatggag atttctgacg 1394341 aagatgctga aaagattgca acagtcggcg acgctgtgaa ctacatacaa aaccagcaat 1394401 aagctgatgc taaaagtccc gccgaaacgc ggggctttag ccctttattc gtgcagttat 1394461 tacagcatgc cgcttttacg cgcgctgtat ccggtttagt cagagaagcg cggtgaacct 1394521 gatgtgccta tggaggttac tatgtcaaaa cactcacatt ataaagataa aaaaaagttc 1394581 tataaaaaag tagaacaatt taaagagttt caagaacgga tttcggttca ctttcaaaat 1394641 gaaaagcttt tgtatcaagc atttacacat tcatcttatg tgaatgagca tcggaaaaag 1394701 ccgtatgaag ataatgaaag gcttgaattt ttaggtgacg ctgttttgga actgacgatc 1394761 tccagattct tatttgccaa atacccggct atgagtgaag gagatttgac gaaattgaga 1394821 gccgcaattg tttgcgaacc gtctctcgtt tcattggctc acgagctgtc attcggcgat 1394881 cttgtcctgt tgggtaaagg cgaggaaatg acaggcggaa gaaagcgtcc tgctctattg 1394941 gcggatgttt ttgaggcatt tatcggagcc ttgtaccttg accaaggatt agagccggtc 1395001 gaaagtttct taaaagttta tgtgttccct aaaattaacg atggtgcttt ttctcatgtg 1395061 atggatttca aaagccagct gcaggaatac gtgcagcggg acggcaaagg ctctctggag 1395121 tataaaatct ccaacgaaaa aggacctgcg cacaaccgtg aatttgaagc catcgtatct 1395181 ctaaaaggtg aaccactcgg agtcggaaac ggccgttcaa agaaagaagc cgaacagcac 1395241 gctgctcagg aagctttagc taaattgcaa aaacaccata cgaaacaata aaatccccct 1395301 tatgactcag ggggatttca gtatgtatgc cgtcttattt gaccaatgtt tatgatagaa 1395361 ttgaaatact tattacataa ggaggatcgc tatgttcctc aaacgtttag acgttatagg 1395421 atttaaatca tttgcagaac ggatttccgt agacttcgtt aaaggcgtga cagcagttgt 1395481 cgggccgaac ggaagcggaa aaagcaacat cacggatgcc attcgctggg ttctcggcga 1395541 acaatcggca cgctctcttc gcggcggaaa aatggaagac atcatttttg ctgggagtga 1395601 ttcaagaaag cgattaaatc tagctgaagt tacgcttact cttgataatg atgatcattt 1395661 cttgccaatt gacttccacg aggtgagtgt cacaagacgt gtgtacagat caggtgagag 1395721 tgagtttctg attaacaatc agccatgccg cttgaaagat attattgatt tatttatgga 1395781 ctctgggctt ggtaaagaag cattttctat tatcagccaa gggaaagtgg aagagatcct 1395841 gagcagcaaa gcggaggatc gccgcagtat ctttgaagaa gcggccgggg tgcttaaata 1395901 taaaacgaga aagaaaaaag cagaaaataa actgtttgag acacaggaca atctaaatcg 1395961 ggtagaagat atattacatg agcttgaagg acaggttgaa cctcttaaaa ttcaagcttc 1396021 aatagcgaaa gactaccttg agaaaaagaa agagctggag catgttgaaa ttgcgctgac 1396081 tgcctatgat atcgaagagc tgcatggtaa atggtcgact cttaaagaga aagtgcagat 1396141 ggcaaaagaa gaagagcttg ctgaatcgtc tgctatttct gcgaaagaag caaagattga 1396201 ggatacaagg gacaaaatac aagcgcttga tgagtcagta gatgagctcc agcaagtttt 1396261 actggtaact agtgaagagc tggaaaagct tgaaggccgt aaagaagtcc tgaaagaacg 1396321 aaagaaaaac gctgtgcaaa accaagaaca gcttgaagaa gccatcgttc agttccagca 1396381 aaaagaaacg gttctgaaag aagagctttc gaagcaggaa gctgtcttcg aaacgcttca 1396441 ggctgaggtg aagcagttaa gggcgcaagt aaaagaaaaa cagcaggctc tcagtcttca 1396501 caatgaaaat gtcgaagaga aaatcgagca gctgaaaagt gattattttg agctgttaaa 1396561 cagccaggct tcgatacgca acgaactcca gcttcttgat gaccagatgt cccaatccgc 1396621 tgtcacattg cagagacttg cggacaacaa tgaaaagcac ctgcaggaac ggcatgatat 1396681 ttctgcgcgt aaagccgcat gtgaaacgga atttgcccga attgagcagg agattcacag 1396741 tcaagtcggt gcatatcgtg atatgcagac aaaatatgag cagaaaaagc gccaatacga 1396801 aaaaaatgaa tccgctctgt atcaggcata ccaatacgtt cagcaagcga gatcaaaaaa 1396861 ggacatgctt gagacgatgc agggagattt ctccggcttt tatcaaggtg ttaaagaagt 1396921 gctgaaagcg aaagagcgcc ttggcggaat tcgcggagcg gttcttgagc tgatttctac 1396981 agaacagaag tatgaaacgg ccattgaaat agcgctcggc gcttctgctc aacacgtcgt 1397041 gaccgacgat gaacaatctg cccgcaaagc gattcaatat ttaaagcaga attccttcgg 1397101 ccgggcgacg tttctgcctc tttctgttat tagagaccgc cagcttcaaa gccgtgacgc 1397161 ggaaacagcc gcccggcatt catcatttct cggggttgcc agtgaacttg tcacatttga 1397221 tcctgcgtat cgaagcgtca tccagaatct tcttggaacc gttctgatca cagaggactt 1397281 aaagggtgca aacgagcttg cgaagcttct cgggcaccgg taccgcatcg taacccttga 1397341 gggagatgtt gtgaaccccg gtggttcaat gacgggcggc gcggttaaaa agaaaaataa 1397401 ctccctcctt ggaagaagcc gggagctaga agatgtgacg aaacggctcg ctgaaatgga 1397461 agagaaaacg gcactgcttg aacaagaggt caaaaccctt aagcactcca ttcaggatat 1397521 ggagaaaaaa ctggctgact taagagaaac cggggaaggc ttaaggttaa agcagcagga 1397581 tgtgaaaggc cagctgtacg aacttcaagt tgccgagaaa aatatcaata cccatttaga 1397641 gctctatgat caagaaaaat ctgctctgtc agaaagcgat gaagagagaa aagtgcgcaa 1397701 acgcaagctt gaagaagagc tctctgccgt atctgaaaag atgaaacagc ttgaagagga 1397761 catagacaga ctgacaaaac aaaaacaaac gcaatcctca acgaaagagt ctctctccaa 1397821 cgagctgact gagctgaaga tcgcagcggc caaaaaagag caggcttgca agggggaaga 1397881 ggacaacctt gccagattaa agaaagagct cactgaaaca gagcttgcgt taaaagaagc 1397941 aaaagaagac ttaagcttct taacgtcaga gatgtcatct agcaccagcg gcgaagaaaa 1398001 gctggaagaa gcagcaaaac ataaattgaa tgacaaaacg aaaacgatcg aactgattgc 1398061 attaaggcgc gatcagcgca tcaagcttca gcatgggctt gatacgtatg agcgtgagct 1398121 gaaagaaatg aaacgcctgt ataaacaaaa aacaacgctc ttaaaagacg aagaagtcaa 1398181 acttggacga atggaagtcg agcttgataa tttactccaa tacttacggg aggaatacag 1398241 cttgtccttt gagggggcaa aagagaaata tcagcttgaa actgatccag aggaagccag 1398301 aaagcgcgtg aagctgatta aactcgcaat tgaagagctg ggtaccgtga acctcggaag 1398361 catagatgag tttgagaggg tcaacgaacg gtacaagttt ctgtcggaac aaaaagaaga 1398421 tttaacagaa gcgaaaaata ccttgttcca agtgattgaa gaaatggatg aagaaatgac 1398481 gaagcgcttt aacgacacat tcgtccaaat ccgctcacac tttgatcaag ttttccgctc 1398541 cttattcgga ggagggcgag ctgaactgag gctcaccgat cctaacgatc tgcttcattc 1398601 aggagtcgag attatcgctc agccgccggg gaaaaagctg caaaacttaa acctcctgtc 1398661 aggcggagag cgtgcgctta ctgctatagc gctcttattc tcaatcctaa aggttcgtcc 1398721 agtgccgttt tgcgtccttg acgaagtaga ggctgcgctc gacgaagcga atgtgttccg 1398781 atttgcgcag tatttaaaaa aatacagcag cgatactcag tttattgtga ttacccacag 1398841 aaaaggaacg atggaggaag cggatgtgct ttatggcgta accatgcagg aatccggtgt 1398901 ttccaaggta atttcagtta agctggaaga aacaaaagaa ttcgttcagt aacgaggaaa 1398961 gaggttaaaa gatgagcttt tttaaaaaat taaaagagaa aatcacaaaa cagacagatt 1399021 ccgtatctga aaagtttaag gatggccttg aaaaaacaag aaactccttt caaaacaaag 1399081 tgaatgatct tgtatcccgt taccgtaaag tggatgagga tttcttcgaa gagcttgaag 1399141 aggttcttat cagcgcggat gtcggtttta caaccgttat ggaattaata gatgagctga 1399201 aaaaagaagt caaacgcaga aatattcaag atccaaagga agtccagtca gtgatttctg 1399261 agaaactggt cgagatttat aacagcggag atgagcaaat ttcagaactg aacatccagg 1399321 atgggcgttt aaacgtaatc cttctggtag gtgtaaacgg cgtcgggaaa acaacaacga 1399381 tcggaaagct tgctcataaa atgaaacaag aaggaaaatc tgttgtactt gccgccggag 1399441 acacttttag agcgggagcc attgaacagc tggaagtatg gggagagcgt acaggagtgc 1399501 ctgtcattaa gcagacggca ggaagcgatc cggcggctgt catctacgat gctgttcatg 1399561 ctgcgaaagc aagaaatgcc gatgtattaa tttgtgatac ggcagggcgt ctccaaaaca 1399621 aagtaaatct catgaaagag cttgaaaaag taaaacgtgt tatcgaaaga gaagttcctg 1399681 aagctccgca tgaggtgctg cttgcccttg atgccacgac cggccaaaat gcaatggctc 1399741 aggcaaaaga attctctaaa gcaacaaatg ttaccggcat tgctttaacg aagcttgacg 1399801 gtacggcaaa aggcggtatc gtccttgcga ttcgcaacga gcttcacatc ccggttaaac 1399861 tagtcggttt aggagaaaaa gttgatgacc ttcaggaatt tgatccagaa tcctatgtgt 1399921 acggactctt ttcagattta gtggaaaaag ccgacgatta agaaaaaggc cccaacatct 1399981 tggggccttt ttctttttta tcttcttact tgataggcga aatgataaag gctgttatca 1400041 gtggatacca gtcttgactc accagaaaaa actctgaatg ggatgatgtc atagtaatga 1400101 acggaaacag atgtgtaata cgtatagtaa ccagcagctg gccccaaata cattggaacc 1400161 tcaaatgttc cgtttgcatc agtcgttcct gaagcagttt gtgttgtgtt tccgaccttc 1400221 gtgtccgctt caaatcttac gggcgcgttt ggcactggct gtccgttttg gtcgagtaat 1400281 ttgccgctta ctgtaatatt gtacttgact cgccaatatt gaccttgtcc gtaattgatt 1400341 ttaccgtata cccctccatc tgtgctgata tttgtgattg aggccttata aggtgcctca 1400401 gcagcgtctg cttgctgtgc cgggaaacct attgtaaaca gggctgccag acataacata 1400461 aacaataaac cgattttttt cataaaaatc ctccttaaaa tagggttcat atacaatatc 1400521 ggaataaatt ggatgatatt tagcgtattt tggaaaagtt aatcgccgct ttgacaagat 1400581 aaaaacttga cagtgtcatt aaaaccgtgt aaactaagtt atcgtaaagg gatttgactt 1400641 aacaaagggg agagctcaaa tgtcactcga aaagacaacg agaatgaatt atctgtttga 1400701 tttttatcag tcgttgttga cgtcaaaaca gaagagctat atgtcgcttt attatttgga 1400761 cgatttctcc ctaggcgaaa tagccgaaga atatgaggtt tcaagacaag ctgtttatga 1400821 taacatcaaa cgaacagaag caatgcttga acaatatgaa gaaaagctgc tccttttgaa 1400881 aaagtttcag gagcgtaaag agatgtttaa taagctgaag gagcttgctt ccggttcaaa 1400941 agaagaggaa gaaattacag ctctgattga agcgcttgag aaattagatt aggaggcggc 1401001 aaactatggc atttgaagga ttagccgacc gactgcagca gacgatttct aaaatccgcg 1401061 gaaaagggaa agtcagcgaa caagatgtaa aagagatgat gcgtgaggtc cgtcttgcgc 1401121 tgcttgaggc tgacgttaac tttaaagtag tcaaggattt tgtcaaaaaa gtaagtgaac 1401181 gcgctgtagg ccaagacgtc atgaaaagtc tgacgcccgg ccagcaggtc attaaagttg 1401241 ttcaagagga actgactgag ctgatgggcg gcgaagagag caaaatcgcc gtcgcaaaaa 1401301 ggccgccgac tgttattatg atggtcggtc tccaaggtgc cggtaaaacg acaacaagcg 1401361 gtaagcttgc gaatctgctg cgcaaaaagc ataatcgcaa accgatgctg gttgctgccg 1401421 atatttaccg cccagccgca attaagcagc tggaaacact cggcaaacag cttgatatgc 1401481 ctgttttctc tcttggcgat caggtcagtc ctgtagaaat agctaaacag gctattgaga 1401541 aagccaagga agaacattat gactacgtca ttttggatac ggcagggcgc ttgcatatcg 1401601 accatgaact gatggatgaa ctgaccaacg tcaaagaaat cgcgaatccg gaagaaattt 1401661 tcctggttgt cgattcaatg accggtcagg acgctgtgaa tgttgccaaa agctttaatg 1401721 aacagctcgg tttaaccggt gttgtgttga ctaagctgga tggagacaca cgcggcgggg 1401781 ctgcgctttc tattcgcgct gtcacaaaca cgccaattaa gtttgcaggt ttgggcgaaa 1401841 agcttgatgc gttagagccg ttccatcctg aacgcatggc atcaaggatt ctcggcatgg 1401901 gcgacgtgct gacattgatt gaaaaagcac aggccagcgt tgatgaagac aaagccaaag 1401961 agctggaaca aaaaatgaga acgatgagct tcacattgga cgattttctg gagcagctcg 1402021 ggcaagtcag aaacatgggg ccgcttgatg agcttctgca aatgatgccg ggtgcaggta 1402081 aaatgaaggg cctgaaaaac atccaagttg atgaaaaaca gctgaatcat gtggaagcaa 1402141 tcatcaaatc aatgactgtt cttgaaaaag aacagccgga tattatcaat gccagccggc 1402201 ggaagcggat tgcaaaagga agcgggacat ccgtacagga agtcaaccgt ctgcttaagc 1402261 agtttgatga aatgaaaaaa atgatgaagc agatgacaaa catgtcaaaa ggcaagaaaa 1402321 aagggtttaa gctacctttt atgtaatcgg ttatacatga taaaaccgtt gttaagaaaa 1402381 aacactttac aaacactttt atcattgtta atatactatc ttgttgaaat attttcggag 1402441 gtgctagtaa aatggcagta aaaattcgtt taaaacgtat gggagcaaaa aaatctcctt 1402501 tctatcgtat tgttgtagca gattctcgtt caccacgtga cggccgtttc atcgaaacag 1402561 tcggaactta caacccggtt gcaaaaccag cggaagtaaa aattgacgaa gagcttgctc 1402621 ttaaatggct tcaaactgga gcgaaaccat ctgatacagt tcgcaacttg ttctctagcc 1402681 aaggaatcat ggaaaaattc cacaacgcta aacaaggcaa gtaatgactg atcaacactt 1402741 ggaagatttg attgtccaca ttgtgacgcc gcttgttgat catccagatg acattcgcgt 1402801 cataagagaa gaaaccgatc aaaagattgc gctgcgctta tctgtccata agtcagatac 1402861 cggtaaagtt atcggaaagc aaggccggac tgcaaaagcg attcgaacag ctgtatttgc 1402921 agctggcgta cagtcttcta agaaagttca atttgaaata tttgactaaa agggagaggg 1402981 ccggcacctc cccttttttt acacgcaaaa aaagggtaaa ctgatagaag cttaggcaaa 1403041 atagaaaagc ctggacgagt aaaagtttta aaagcgggga gcttggtgcg atgcaaatta 1403101 ttcaccgtgt agccgttatg caagtcttaa ccgagcgcag taaagaaaag cttttagctt 1403161 cttttgctga gaagaaacaa atgcttgaac gagaatgcag ccagctctat tttcagctta 1403221 gaaaacatga gaaagaacag caaaacccta atatgattga acaatttaaa aaggcaatag 1403281 aaaagcgaaa agatgatata aaaatcattg attttcaaat tgctcaagta catacattgc 1403341 cgcttggcag tgagttgaaa gaaaaggaag tcgatgcgct gctgacgatt gaagccgggg 1403401 atgactggca tgagaaaaca gcagcgaaca ccatcgtcat aaaagacgga aaagtaattg 1403461 aaattcgcca gaggtgatca tatgacaaag cgatggttta atgtaggcaa aatcgtaaat 1403521 acccacggaa tcaaaggcga agtgcgggtg atttcaaaaa cagattttgc cgaagaacga 1403581 tacaagccgg gaaacacgct gtatttgttt atggacggcc gtaacgaacc agtggaggta 1403641 acggtaaaca cacatagact gcataagcaa tttcatctcc tgcagtttaa agaaagacaa 1403701 aacctaaatg aagtagaaga gctgaaaaac gcaatcatta aagttcctga agaagaatta 1403761 ggagagctga atgagggtga attttatttc cacgaaatta ttgggtgtga agtatttact 1403821 gaagaaggcg aactcatcgg aaaggtcaaa gaaattttga cgcctggagc caatgacgtt 1403881 tgggtcatcg gacgaaaagg aaaaaaagac gcactcattc cttacattga atcagtggtt 1403941 aaacatatcg atgtcaggga aaagaaaatt gagattgaac tcatggaagg gttaatagac 1404001 gaatgaaaat cgattttttg acgctgtttc ccgaaatgtt tgaaggcgtg ctcggctcat 1404061 cgattcttca aaaagcccag gaaaaagatg cggtgcagtt tcaagtcgta aatttccgag 1404121 agtactctga taacaagcac aatactgttg atgattatcc ttatggcggc ggggcaggca 1404181 tggttctcaa gccccagcct gtttttgacg cggtcgagga cctgacatca aaggcagccg 1404241 ctgctccgcg tattatcctc gtatgcccgc aaggtgagcg ttttacccaa aaaaaagccg 1404301 aacaattagc taaggaagag catttgctgt tcatttgcgg ccactatgaa ggctatgatg 1404361 aacgcattcg cgagcacttg gtaacggatg aaatatcaat tggcgacttt gttctgacgg 1404421 gcggtgagct ccctgcaatg atgatcgcag acagtgtggt cagactgctt ccgggtgtac 1404481 tgggtaaaga ggcttcccat attgaggatt ccttcagcac cggactttta gagcacccgc 1404541 attatacaag accggcagat tacaaaggtt taaaagtgcc tgaaacactc ttgtcaggaa 1404601 accatgcaaa aattgaagaa tggcggaata aagaatcgat cagaaggacc tacctaagac 1404661 gtccggatct gttgaaagac cacccgctta cagagcagca aagaaagtgg atttctgaat 1404721 gggaaaaaga atagatttta ttgcataggc tatgaaattg tgataagata ctacttgtgg 1404781 cttaagcggg cttatccgct gcaagcttga aaacgatgtt ccgctgtgcc ggtttttgtg 1404841 gccaagagca tctgttggaa ggagttgaaa acgatgcaaa aactaattga agatatcaca 1404901 aaagaacagc ttcgtactga tcttcctgcg ttccgtcctg gtgacacttt acgtgtacac 1404961 gttaaagttg ttgagggtaa ccgtgagcgt atccagatct ttgaaggtgt tgtgattaag 1405021 cgtcgtggtg gtggaatcag cgaaacgttc acagttcgta agatttctta cggtgttggc 1405081 gttgaacgta ctttcccagt acacacacca aaaatcgcga aaatcgaagt tgtacgttac 1405141 ggtaaagtac gccgtgctaa actttactac ctgcgtgaac ttcgcggaaa agcggctcgt 1405201 attaaagaga tcagacgata atgataacga acgaaaagag cttgttacct gtaacaagct 1405261 ctttttttat acagaatttg aaaatgccgg acaggcatcg taaaatacat aaaggacaac 1405321 aatgaatcat gcatactgaa gataaaggcg gtgttcgtgt cacatgacaa ttcaatggtt 1405381 cccgggccat atggcaaaag caagaaggga agtaaccgaa aaattaaaat taatcgatat 1405441 cgtatatgaa ttggtagatg ccagaattcc aatgtcatca agaaacccaa tgattgaaga 1405501 tattctaaaa aacaagccgc gaattatgct gttaaacaag gctgacaaag cagatgcggc 1405561 agttacacag cagtggaaag agcactttga gaaccagggg atccgctctc tgtctattaa 1405621 ttctgtaaat ggacaagggt taaatcaaat tgtgcctgca tcaaaagaga tcctccaaga 1405681 aaaatttgac cggatgcgtg cgaaaggtgt gaagccgaga gcgattcgcg ctttgattat 1405741 cggcattcca aacgtcggaa aatcaacgct catcaaccgg cttgcaaaga aaaacatagc 1405801 aaaaacggga gacagacctg gtattacgac ttctcaacag tgggtcaaag ttgggaaaga 1405861 attagagcta ttagatacac cgggaatttt gtggcctaaa tttgaggatg agcttgtcgg 1405921 tttgagactg gcagtcaccg gggctattaa agactcgatt atcaatttgc aggacgtggc 1405981 cgtgtttggt cttcgttttc tcgaagaaca ttacccagaa cggcttaaag agcgttatgg 1406041 ccttgatgag atcccagagg acattgccga gctgtttgat gcaataggtg aaaagcgggg 1406101 ctgtctcatg agcggtgggc tcatcaacta cgataagacg actgaagtca tcattcgcga 1406161 tattcgcact gaaaagttcg gcaggctgtc atttgaacag ccgacgatgt aaaggcgcgc 1406221 agaaatgcgg gtctttattt tttcttggct gaaccgatac atacagtaag ggagaagaga 1406281 aagtgaatac attaaccgta aaggacatta aagaccgttt gcaggaagtg aaggatgcac 1406341 aagacccatt tattgcccaa tgcgaaaacg acccgagaaa aagcgttcaa acgcttgtag 1406401 agcaatggct taaaaagcaa gcgaaagaaa aagcgctgaa agaacaatgg gtgaatatga 1406461 cttcctatga aaggctggca agaaacaaag gatttcgctt gattgcaggt gttgacgagg 1406521 tcggccgggg gccattggca ggaccagttg tcgccagcgc agtcatcctt ccagaggaat 1406581 gtgaaatact tgggctgaca gactccaaaa agctttcaga gaaaaaacgc gaggaatatt 1406641 acgagcttat tatgaaggaa gcactggcgg tcgggatagg aattgtagaa gctactgtga 1406701 ttgatgagat caatatatat gaagcttcaa aaatggcaat ggtgaaagcg atacaggatt 1406761 tgtcggatac acctgattat ttgcttgttg acgcaatgac acttccgctc gacacggctc 1406821 aggcgtcaat tataaaaggc gatgccaaaa gcgtgtctat tgcggcaggt gcgtgtatcg 1406881 caaaagtgac gagggaccga atgatgagcg cttatgccga aacgtatccc atgtacggct 1406941 ttgaaaaaaa taaaggctat gggacaaaag aacatttgga agctctcgct gcatacggcc 1407001 caactgaatt gcaccgcaaa actttcgctc ctgttcaatc tttcagataa atcaccatgg 1407061 acaaggaggc acctttttaa aatgaacata cgaaatgatg tgcaaaaggc gctgcagcac 1407121 cttttcgggc gtacagccgt cccgcaggaa acatcaaaag taaacgaagc gctaaacggg 1407181 gagaagcgtc tcctcttagg aaaagtgctt cgtttactag gagatcagca tgccctgatc 1407241 caagtcggca atcaaactgt tcagggaaaa cttgaaactc agcttcgtcc tcaggcatac 1407301 tattggtttt cctacgaaaa aaaaacggca gagcaaacag gccgtcttca ggtcgttcaa 1407361 agctttgatc aaaatcctaa aaccattcag gatgcagctg gcaaactttt aaatgctatt 1407421 tcagtgaaga cgtcaaacgc agctctcatg atgacaggag cgatgctgaa aagcaaaaca 1407481 cccgtaacag aaaatgatat caaaacagct gtccgctgga tggacacgct gccttcgcaa 1407541 gacacaaaaa aagcagttga aacggttctc ttcgctttaa agcgtgatct tcccattcac 1407601 tccgagattt tgaatggtgt tcacgctgtg aaatcgcctg ttccgttgca tcagcacgta 1407661 tcccagctgc tacaggcaat cgaccaaaac cctcagcaga gccaaatgat gtcaaagcta 1407721 aaggaagcag tcacggtgct tttaaatagt gaaatcgatg tccatgcaga acggctgatt 1407781 gataagctta tttctttaac cgacaatacg aaagcacctt ctccgacgaa tacagctgga 1407841 agcagggagc ttagcacacc agctggctcc cccggaaaag ccagcctgcc gattgcaaat 1407901 cacacagcag aacagggaag catacaagaa gagcctgtta aaacagcagc agacattcca 1407961 attaaagaag cccgccagct gctggtgaag ctgacggaat ctgctgaaaa aaacagtctc 1408021 caaattgtga aagaagcagc aaattggatt aaagcggctg cttcatcggg tgatagtaag 1408081 tcacttgcag cttcagctgt tttacaggcg gcacaagtca cagatcagga agccgaagtc 1408141 tttttaaagg ctgttcagca gacagcaccc catttggcgg ataaggcaga tgttctttct 1408201 ttcttatcca aagtgaaaac ggcaatcggc gcaagggacg aggttgcgtt cattaaagcg 1408261 tttgaacaag gaagcgcagt cacatctggc gaaatgcaat ccatcaagct ggctctttct 1408321 gccttaagag catcgcatga ggtagccgaa ccagtcaaac aagaagccga tcagcttttt 1408381 cataaattaa atggccagct tttcatgcag caggaccatc catcatacag ccaaattgta 1408441 atgtcatttc cgatgttttc gaagtcaggg gttcaggaca tgactgttct gtttaaagga 1408501 aagaaagaag cggatggaaa gcttgatcct tcccattgcc gccttttgtt tttgctgcag 1408561 cttgatacac taaaagaaac cgtcgttgat tgcttggtac agcaaaaagt catgaccatt 1408621 acaatagaga ctgatttcga gctgcaggct gcgatcgatc cgatggtgcc cgcgcttaaa 1408681 caggggctaa aggaaatggg gtacagcctt tcaggggtaa acgctaaaaa aagggttcac 1408741 accgaagaaa aggcttcaat cgatcaatat ataacaagta tcagtgatca ggaagtggat 1408801 gtgaaaatat gaaagagcag acaccgatca gaaaagctgt tgctctccat tatgacgaac 1408861 aaaaagacaa ggcgccgaga gtgattgcca cagggaaggg ccatgtagct gacaacatta 1408921 taaaagaagc gaaaaaagca ggggtcccga ttcaagaaga tcggaccctt gtcgaattaa 1408981 tgcgccattt gacggtagat gatcaaattc ctgaagctct ttatgaaacg gtagccgaga 1409041 ttttttcatt catttacaaa ttggacgaaa gcgtaaaaaa caaaaaatag ctaaaatatt 1409101 ccccatcctt ctttgaaatt tatgttttta ataaagtaaa agtttgaatg tttagaagga 1409161 ttaaaagatt ttgcatcgaa ctgtagacaa ttcttccagt attattatag aatgaaagcg 1409221 cagtctattt tagttttgtt acataagtta ggaggatggg aaatgaatat ccatgagtac 1409281 cagggaaaag aagtcctcag aaaatatggg gtatctgttc ctgaaggtaa agtggctttt 1409341 acagcagaag aagcagttga gagtgcaaag agcttatcca gctcggttta tgtcgtaaag 1409401 gctcaaattc atgctggcgg tcgaggcaaa gctggtgggg taaaaatagc aaaatcatta 1409461 gacgaagtaa aagcgtatgc cgaagaacta ttagggaaga ccctagttac acatcagacg 1409521 ggtccggacg gccaagtaat aaaacgctta cttattgaag aaggctgcga tattaaaaaa 1409581 gaatattaca tcggtctagt gcttgaccgc gccacttcaa gaatcgtttt aatggcttct 1409641 gaagaaggcg gaacggaaat tgaagaggtt gcggagaaaa caccagaaaa aatcaaaaaa 1409701 gctgtcattg atccagctgt tggccttcaa ggctatcaag ccagagaaat tgcattcgct 1409761 attaatattc caaaagagct cgtgggaaaa gctgctaaat ttatgcttgg actatataaa 1409821 gcgtttgttg agaaagactg ctcaatcgcc gaaatcaatc cgcttgttgt gactggcgac 1409881 ggaaatgtga tggcgcttga tgcaaaattg aattttgaca gcaatgcgtt gtaccgacaa 1409941 aaggacatta tggaatacag agatttggat gaagaagatc cgaaagaaat tgaagcgtcc 1410001 aaatatgatc taagctacat ttcccttgat ggaaatatcg gctgtatggt aaacggcgcg 1410061 ggacttgcaa tgtctacgat ggatattatc aagcattatg gaggagaacc ggccaacttc 1410121 cttgatgtgg gcggcggtgc aaccgcggaa aaagtcacgg aagcatttaa aatcattctt 1410181 tctgatcaaa acgttaaagg gatttttgtc aacattttcg gcggcattat gaaatgtgat 1410241 gtcatcgcag aaggggttgt tgaagcgact agacaagttg gtttgacatt gccgcttgtc 1410301 gtccgtcttg aaggcacaaa cgtggatcta gggaagaaaa tccttagtga atcaggatta 1410361 aacattacat ctgcggaatc aatggctgac ggcgcgcaga aaatcgtatc cttagtttaa 1410421 gaaagaatga aaggcagggg accaaataat gagtgttttc attaataaag atacaagagt 1410481 tattgtgcaa gggattacag gttctaccgc tttatttcat acgaagcaga tgcttgaata 1410541 cggcacaaat atcgttggcg gtgtaacacc tggaaaaggc ggaacagaag cggaaggtgt 1410601 tcctgtattt aatacagtgg ctgaagcagt tcaaacaacc ggcgctaacg cgtctgttat 1410661 atatgtgccc gcaccgtttg cagctgatgc gattatggaa gcggtagatg cggagcttga 1410721 tctcgtgatt tgtatcacag aacatatccc ggttttggat atggtgaagg tcaaacgctt 1410781 catggaaggc aagaaaacga gactgatagg gccgaactgt cctggtgtca ttacgcctga 1410841 agaatgtaaa atcggcatta tgcccggata catccataaa aagggtcatg taggcgttgt 1410901 atcacgttca ggaacattaa catacgaagc ggtgcaccag ctctcagaag cgggtgtagg 1410961 gcaatctaca gctgttggaa tcggcggcga ccctgtaaat ggaacaaact ttattgacgt 1411021 tttaaaagcg tttaacgaag atcctgacac acacgcagtc atcatgattg gcgaaatcgg 1411081 cggtacggcc gaagaggaag cggcagagtg ggtaaaagcc aacatgacaa aaccggtagt 1411141 cggttttatt ggcggtaaaa cagcacctcc tgggaagcgc atggggcatg caggcgccat 1411201 tatttccggc gggaaaggga cagctgatga aaaaatcaaa acccttaatg catgcggaat 1411261 cgaagttgca gagacacctt ctgtcatggg tgaaacctta atcaaggtgc tgaaagagaa 1411321 gaacttgttc gaaacttgta aaacgcatta ataaaaaagg gacagccgtc aaggctgttc 1411381 ctgctttttc taacaaaagg aggtcaatct attggatcag gccgctgtct gcctaacgat 1411441 ttgcagaatc aatcaattat tatccccatc ccttctatta aaatggtgga aagccgatcc 1411501 gtctatgtcg ctgacatcac ccgtgttaca aacggttact cgtgatcaaa taaaagcagc 1411561 tgcattaaaa aacgaaatag aacaatttta tccaaagctc ccgcgtgtac ttgctgctta 1411621 tcgtgagcaa ggcattaaca ccatccctat ttcttcaaag caatatcctt tctggcttaa 1411681 aagcatttat gatccccctg ccgtactgtt tgcaaaaggt gatatgactc ttctttcgaa 1411741 agggagaaaa attggaattg taggcacaag aaatccaaca gcttatggga aacaagttgt 1411801 caatcatctt acaaaagaga tctgtcgtaa aggttgggtg attgtcagcg gactggcgtc 1411861 tgggatagac ggaatgtccc atgctgcaag tattaaggcg aaggggcgga caattggcgt 1411921 cattgcaggc ggatttcaac acatttatcc ccgagaaaac cttcagttag cagatcacat 1411981 ggctaaacac catatcctgc tgtcagagca cccacctgaa actaaacccc aaaaatggca 1412041 tttccctatg agaaaccgta ttatcagcgg actaagtgaa ggcgttattg tcgttcaggg 1412101 caaagaaaaa agcggttcgc tgattactgc ctatcaagca ttggaacaag ggagagaggt 1412161 atttgccgta cccggttcat tgtttgaccc ttacgccgga ggtcctataa aactgatcca 1412221 gcagggggct aaagccatat ggtcagcaga ggatattttc gaggaacttc ctgagagaaa 1412281 cgttcaatat acggaaccct tttgaattat cgtttgacaa acggtattgt aatatttaat 1412341 aatagtgagg atttaaagtt gcatattgtt ttctatttaa ttaatgacgt tcatgataaa 1412401 gaatgaaatg ttgaaagcca aataaagaca gctgcaaaaa taaaattgaa atatcttgaa 1412461 aagagagaga acacctcttg agggggatga aaatgtctga ttatctagtc atcgtggaat 1412521 cgcccgctaa ggcgaaaacg attgaacgtt acttaggtaa aaaatataaa gtaaaagcat 1412581 caatgggaca tgtccgggat cttccaaaaa gtcaaatggg agttgacata gaacagaatt 1412641 ttgaaccgaa atatattacc attcgaggta aaggcccggt attaaaagag ctgaaaacgg 1412701 ctgcgaaaaa agccaaaaaa gtgtatctcg cagctgaccc cgacagagaa ggggaagcga 1412761 ttgcatggca tttggcacac agtcttgatt tagatctcaa ctcagactgc cgtgtggtgt 1412821 ttaacgaaat tacaaaagac gctattaagg aatcgtttaa gcatccccgc atgatcaata 1412881 tggatttagt ggatgcacag caagcgagac gtattttaga caggcttgtc ggatataaaa 1412941 tcagtccaat cttatggaaa aaagtcaaaa aagggcttag cgcaggacgc gtgcaatccg 1413001 ttgccctccg tttgattatt gaccgtgaaa aagagattaa cgactttaag cctgaggaat 1413061 attggacaat tgacggtacg ttcttaaaag gtcaagaaac ctttgaagcg agctttttcg 1413121 ggaaaaacgg caaaaaactt cctttaaata gtgaagctga tgtaaaagag attctttctc 1413181 agctcaaagg gaatcaatat acagttgaaa aagtaaccaa aaaggaacgc aaacgtaatc 1413241 ctgctttgcc ttttaccact tctaccctgc agcaggaagc ggctcgcaag ctcaatttca 1413301 gagcgaagaa aacgatgatg attgcacagc aattatatga aggaattgat ttaggaagag 1413361 aaggaacggt tggtctgatc acgtatatga gaacggattc aacccgtatt tcaaatacgg 1413421 ctgttgatga agcagctgca tttattgatc agacatatgg aaaagagttc ctaggcggaa 1413481 aacggaagcc tgcgaaaaag aatgaaaatg cccaggatgc ccacgaagca attcggccga 1413541 catcagttct tagaaaacca agtgaattaa aagcagtcct cggcagagac caaatgagac 1413601 tgtataaatt aatttgggag cgttttgttg ccagccaaat ggcaccggct gttctcgata 1413661 caatgagtgt cgacctgaca aacaacggtt tgacatttcg tgcaaatgga agtaaagtca 1413721 agttttccgg gtttatgaag gtgtatgttg aaggaaaaga cgatcaaatg gaagaaaaag 1413781 accggatgct gcctgactta caagaaggcg acacggtatt atcaaaagat atagaacctg 1413841 agcagcattt tacccagccg cctccgcgat atactgaggc ccggcttgtt aaaacccttg 1413901 aagaacgcgg tatcggccgt ccatccacat atgctccgac acttgatact attcagcggc 1413961 gcggctacgt ggcattggat aataaacgtt tcgttccgac tgaattaggt cagatcgttc 1414021 ttgacttgat catggagttt ttccctgaga tcattaacgt tgagtttaca gctaaaatgg 1414081 agagagatct tgatcatgtt gaagaaggaa ataccgaatg ggtcaagatt atcgataatt 1414141 tctacaccga ttttgaaaaa cgcgtcaaaa aagccgaatc ggaaatgaag gaagttgaga 1414201 ttgaaccaga gtatgctgga gaggattgtg aattgtgcag ttctccaatg gtatataaaa 1414261 tgggacggta cggtaaattc ttagcttgct ccaacttccc tgactgccgg aacacgaaac 1414321 cgattgtgaa acaaatcggt gtgaagtgcc cgagctgcgg agaaggaaac attgttgagc 1414381 gaaaatcgaa aaagaaacgg gtgttttacg gctgtgaccg ttatccggac tgtgaattcg 1414441 tatcatggga caaaccaatt gaacgaaaat gcccgaaatg cggaaaaatg ctcgtcgaga 1414501 aaaaactcaa aaaaggtata caagtccaat gcgtggaatg cgattataag gaagaaccac 1414561 agaagtagcg gtgagcaggg tcttgctcac cttctttgtg tgttaaaaga aggccttgaa 1414621 taataaacta ggagatgtga aagatgaacc aacaaacagt gaatgtaatc ggagccggac 1414681 tcgcaggaag tgaagcagca tggcagcttg ccaaacgtgg gattcaagtc aaattgtatg 1414741 aaatgcggcc agttaaacaa acgcctgcgc atcatacaga taaatttgct gagcttgtct 1414801 gcagcaactc tcttcgctct aatacacttg ctaacgctgt cggtgtatta aaggaagaaa 1414861 tgcgtgcgct tgattcagcc attatcgctg cggctgacga atgttcggtg cctgccgggg 1414921 gcgctcttgc agtagaccgt catgaatttg ccgcaagtgt gacaaatcgg gtgaaaaatc 1414981 atccaaacgt aaccgttatt aatgaagaag tgactgaaat tcctgaaggc cctactatca 1415041 tcgcaacggg tccgttaaca tctgaatcgc tgtctgccca gctgaaggag ctgactggag 1415101 aggactattt atatttttat gacgcagcgg cgccaattgt agaaaaagac agccttgata 1415161 tggataaagt gtacctgaaa tcccgttatg ataaaggtga agcagcatat ttgaactgcc 1415221 cgatgacaga agaagagttt gaccgttttc atgaagcatt aacatcagca gaaacagtgc 1415281 cgttaaaaga atttgaaaaa gagattttct ttgaaggctg catgccgatt gaagtcatgg 1415341 caaaacgggg taagaaaaca atgcttttcg gtccgatgaa accagttggt ctagagcatc 1415401 ctgttacagg aaaacgccct tatgccgtcg ttcagctcag acaggatgat gctgcgggaa 1415461 cactttataa tattgtagga ttccagacac atttaaaatg gggagaccaa aaggaagttc 1415521 tcaagttgat tccaggactt gaaaatgtag aaatcgtcag atatggcgtg atgcatagaa 1415581 acacatttat taactctcca agcctgttaa agccgactta tcaatttaaa aaccgcagtg 1415641 atctgttctt tgcaggccaa atgacgggag tagaaggata tgtggaatca gctgcctcag 1415701 gacttgtagc aggcattaat gcggcgaagc ttgtattggg agaagagctt gtgatcttcc 1415761 ctcaggaaac agcaattggc agtatggcac attatattac aacaacaaac cagaagaact 1415821 tccagccgat gaatgcaaac tttgggcttt tgaaagaatt gccagttaaa attaaaaata 1415881 aaaaagaacg aaatgaacaa tacgcgaacc gtgcgattga aacaattcaa acaatttcga 1415941 aaacaatata ggtattgatt gcaacctgag cgcgatttgt gataccattt aaaagccctt 1416001 cctggggagg tattaggcat ggagaatgtt aagaatttcg taaagttatt cgttgaatat 1416061 ttacaaattg aaaaaaatta ttcacaatat actattgtga attatgtgga ttcaattgaa 1416121 gaattcgaga ctttcctgcg cgttcaaggt ataaatggat ttgaagaagc tgcatatcaa 1416181 gatactagga tttttttgac agaagcctat gaaaaaggtt tatcgagaag aacaataagc 1416241 aaaaagatat ctgcattaag aagcttttat aagtttctga tgcgggaaaa gcttattgaa 1416301 gaaaatccgt ttcagcttgt tcatctgcca aaacaggaga aacggatacc gaagtttcta 1416361 tatcaaaaag agcttgagga gctgtttgaa gtttcagata taagccagcc ggccggaatg 1416421 agggatcaag cgctgttaga gctgctctat gccactggaa tgagggtcag tgaatgctgt 1416481 tccataacta ttaacgacgt tgatttattt atggacactg tgcttgttca cggtaaaggc 1416541 aagaagcagc gctatatccc ctttgggtct tatgcccgcg aagcgttgaa ggtatacatg 1416601 aatagcggaa gacagtgctt gctgatgaag gcaaaagaac ctcatgatct attattcgta 1416661 aatcaaagag gcggaccgct tacagcccgt ggcatcagac atattttaag cgggcttgtt 1416721 caaaaagcgt caagcacttt acatatccat ccgcatatgc ttcgacatac gttcgccacg 1416781 catctgttaa atgaaggagc ggatttgaga agcgttcaag aactgctcgg gcattccaat 1416841 ctgtcttcta cacagatata cacgcacgtt tcgaaggaaa tgttgagaaa cacatatatg 1416901 tctcaccatc caagagcatt taagaaaaat taaaggaggc cctttatgtc atcttttcat 1416961 gcgaccacaa tatttgccgt acagcataaa ggacgaagcg ctatgtccgg agacggccaa 1417021 gtaacatttg gtcaggctgt tgtcatgaaa cacacggcac ggaaagtgag aaaactgttt 1417081 aacggcaaag ttcttgctgg ttttgcggga tctgttgcag acgctttcac tttattcgaa 1417141 aagtttgaag ctaagcttga agaatataac ggcaacttaa aacgggcggc tgttgagctt 1417201 gcaaaggaat ggcgcagtga taaagtgcta agaaagctcg aagccatgct gattgttatg 1417261 aatcaggata ctttgcttct cgtatcggga acaggcgagg tgatcgaacc agatgacggc 1417321 attctcgcga ttggatcagg aggcaattac gctttggcag cgggaagagc actgaaaaag 1417381 catgccgggg aaagcatgtc tgcaagtgag attgccagag ccgcgttaga aacagcaggc 1417441 gaaatttgtg tttacacgaa cgatcaaatc atactggaag agcttgaata gaaaggactt 1417501 gaggcgcatg gaaaaaaaac cgttaactcc tagacagatt gtagatcggt tagaccaata 1417561 tattgtcggt cagcaaaatg cgaaaaaagc tgtcgccgtg gcattaagaa accgctatag 1417621 aagaagtctt ctggatgaaa agctgaagga cgaggtcgtt ccgaaaaaca ttttaatgat 1417681 gggtcctacc ggcgtcggga aaactgaaat tgccagacga atcgctaagc tttcaggtgc 1417741 gccatttatc aaaattgaag ctactaaatt taccgaagtc ggctatgtag gcagagatgt 1417801 tgaatcaatg gtcagagatc ttgtggagac ttctgttcgg cttataaaag aagagaaaat 1417861 gaatgaagta aaggaacagg cagaagaaaa tgcaaacaaa cgcattgttc gtctgttagt 1417921 tcctgggaag aaaaaacaat ctggtgttaa aaatccgttt gaaatgtttt ttggaggcag 1417981 ccagccgaat ggtgaagatg aggcggagag ccaggaagaa gcaaacatcg aagaaaaaag 1418041 aaaacgaatg gcgcatcagc tggctttagg agagctcgaa gactactatg taacagtaga 1418101 agtcgaagaa cagcagcctt ctatgtttga catgctgcag ggctcgggta tggagcagat 1418161 gggtatgaac atgcaggatg cgctgagcgg attaatgcca aagaaaaaga agcggcgcaa 1418221 aatgacagtc agagaagcca gaaaagtcct gacgaatgaa gaagcaagca aactcatcga 1418281 tatggatgaa gtcggccagg aagctgttca gagagcagaa gagagcggga ttatctttat 1418341 cgatgagatt gataaaatcg caaagaacgg cggtgcatct tcttctgccg atgtttcaag 1418401 agaaggtgtt cagcgggata tccttccgat tgttgaaggt tctaccgttg tcacaaaata 1418461 tggttctgta aaaacagacc atgtattatt tattgcagca ggagcgtttc atatggccaa 1418521 accgtctgat ttgattcctg agctgcaggg gcgtttcccg attcgtgtag aactgaacaa 1418581 actcacggta gacgacttcg tgagaatttt ggttgagccg gataatgcgc tgctgaaaca 1418641 atatcaggca ttattgcaga cagaaggtat atctcttgaa ttttctgacg aagctattca 1418701 taagattgct gaagttgctt atcatgtgaa ccaggacaca gataatatcg gtgcgagacg 1418761 ccttcataca atacttgaac gcctattaga agatttgtcg tttgaagctc cagatgtaac 1418821 gatggagaaa ataacgatta caccacagta tgtcgaagaa aagctcggaa cgatagccaa 1418881 aaacaaagat ttaagtcaat ttatattgtg aaaaatttaa tatgaggaat gtttaggagg 1418941 attatttatc atggctttat tacaaaaaac aagaattatt aactccatgc tgcaagctgc 1419001 ggcagggaaa ccggtaaact tcaaggaaat ggcggagacg ctgcgggatg taattgattc 1419061 caatattttc gttgtaagcc gcagagggaa actccttggg tattcaatta accagcaaat 1419121 tgaaaatgat cgtatgaaaa aaatgcttga ggatcgtcaa ttccctgaag aatatacgaa 1419181 aaatctgttt aatgtccctg aaacatcttc taacttggat attaatagtg aatatactgc 1419241 tttccctgtt gagaacagag acctgtttca agctggttta acaacaattg tgccgatcat 1419301 cggaggcggg gaaagattag gaacacttat tctttcgcgt ttacaagatc aattcaatga 1419361 cgatgactta attctagctg aatacggcgc aacagttgtc ggaatggaaa tcctaagaga 1419421 aaaagcagaa gaaattgaag aggaagcaag aagcaaagct gtcgtacaaa tggctatcag 1419481 ctcgctttct tacagtgagc ttgaagcaat tgagcacatt tttgaggagc ttgacggaaa 1419541 tgaaggtctt cttgttgcaa gtaaaattgc tgaccgtgtc ggcattaccc gttctgttat 1419601 tgtgaacgca ctcagaaagc tggagagcgc cggtgttatc gagtctagat cattaggaat 1419661 gaaaggtact tatatcaagg tactaaacaa caaattccta attgaattag aaaatctaaa 1419721 atctcattaa tcacaaaaag aacccttttt gagggttctt tttttatttc aaataaagga 1419781 aatcaataag ctttatttcc tgggttgaaa gtctttctat gtaataattt taataaattt 1419841 tgcatttttc ttcaaaaagt ttcaaaaatg ccgaaaagaa aggagaaaaa acagaaattc 1419901 tgctattttc aggcttatat caaggcgaga aatgtagttc taacaatcta ggactttata 1419961 cctagttgca aaatagataa ttgtgaggac atttttttac acgaacttca tagactttat 1420021 gcctgttatt tcttacaata agcatatagt tttacaattc tcgacaagga tattgagggt 1420081 gaaaaaaact gaaatggagg taagtggatt tgagcttatt ttctggaacg atacaaaatc 1420141 ttgaaaatgc cttgagcaga gcggatatta agcaaaaagt cataactaat aatatcgcca 1420201 atatagatac accgaactat aaggcaaaaa aagtctcttt ccaaaattta ttagatcaag 1420261 aatcctcgcg tcttgaagcg ataaaaacag actatcgtca tgttgatttt tctgatactg 1420321 attcgaatta ttcaattgtt gcgagcggag atacatcgta tcagcaaaac ggaaacaatg 1420381 ttgatgttga caaagagatg acagaattgg cgcaaaatca aatcaactat caagctttgg 1420441 ttgaaagaat gaacggtaaa tttaattcgc tgaagaccgt attaacagga ggaaaatgat 1420501 gacagctttt catagcttaa atgtttcagc atcggcttta acagctcagc gagtcagaat 1420561 ggacgttgta tcatctaact tagcaaatat ggatacgaca agagctaagc aggtgaatgg 1420621 agagtgggtg ccttacagaa gaaaaatggt ttcccttcag tcaaaaggtg aatcgttctc 1420681 ttccattctc aattctcaaa tgagcggaag cgggaatgct ggaaacggtg tgaaggtttc 1420741 aaaaattacg gaggatgatt cggattttaa tcttgtctat gatccgacag accctgatgc 1420801 aaacgctgaa ggatatgtac aaaagcctaa tgttgatcca ttaaaggaaa tggttgatct 1420861 tgtcagcagc actagatcat acgaggcgaa tgtcacggcg atgaatgcca caaagggaat 1420921 gctgatgaag gcgttagaaa tcggaaagta ggcgaactgt taaacaaggt gaaaaaacga 1420981 tttaattaag gtattagggg gataacaatg caatccttga attatgaaga tcaggtgctt 1421041 tggacgcgct ggaaagagtg gaaagatcct aaagccggtg acgacttaat gcgccgttac 1421101 atgccgcttg tcacatatca tgtaggcaga atttctgtcg gactgccgaa atcagtgcat 1421161 aaagacgatc ttatgagcct tggtatgctt ggtttatatg atgcccttga aaaatttgac 1421221 cccagccggg acttaaaatt tgatacctac gcctcgttta gaattcgcgg cgcaatcata 1421281 gacgggcttc gtaaagaaga ttggctgccc agaacctcgc gcgaaaaaac aaaaaaggtt 1421341 gaagcagcaa ttgaaaagct tgaacagcgg tatcttcgga atgtatcgcc cgcggaaatt 1421401 gcagaggaac tcggaatgac ggtacaggat gtcgtgtcaa caatgaatga aggttttttt 1421461 gcaaatctgc tgtcaattga tgaaaagctc catgatcaag atgacgggga aaacattcaa 1421521 gtcatgatca gagatgacaa aaatgttccg cctgaagaaa agattatgaa ggatgaactg 1421581 attgcacagc ttgcggaaaa aattcacgaa ctctctgaaa aagaacagct ggttgtcagt 1421641 ttgttctaca aagaggagtt gacactgaca gaaatcggac aagtattaaa tctttctacg 1421701 tcccgcatat ctcagatcca ttcaaaggca ttatttaaat taaagaatct gctggaaaaa 1421761 gtgatacaat aatgaatttc atggttagcg agtgaaaaac atgtcaacac tattatggct 1421821 tttaagcttt atgctccacg gcgttcttct gtacgctgtc attatcctgt atacgaggct 1421881 cgctgcagtg aaagaaacag aaaaacagca aaaacagata cttgaagaga cggaaaacac 1421941 cttggcggca tttctgcttg aattaaaaga agaaaatgag aaactgatag aaaataaagc 1422001 ttcatctgca agtcaatcag atgaagaatc ccaaaagtca ggccttcaga cctctgaaac 1422061 atatcaagag cgggatccag tccaagaggc agagaatctt cctgaacata ttgaaggtct 1422121 gattacagag gttgaccgtc gggaagagct cgtaaacagt gaggtccaat catttgaaga 1422181 ccaggtcata gaattatatg aacagggata ttcggcaagt caaattgccc agaaaatgaa 1422241 gagcggaaag acagaaatcg agctattttt aaaatttcgc tccaaaggtg taaaggattc 1422301 ttgattgtcg gataaagctg tgttatatta tgtcttggtg ttaaatacac acgcttaacg 1422361 atttatgcag agggtgctgc aggcggcagt tctgtacaaa aatgacctaa gcggaggaaa 1422421 aaaaccatta tattaggagg aaataacatg tcagtcattt ctatgaagca attgcttgaa 1422481 gctggtgttc acttcggtca ccaaacacgc cgttggaacc caaaaatgaa gcgttacatt 1422541 ttcacggagc gtaacggaat ctacatcatt gaccttcaaa aaacagtcaa aaaagtagag 1422601 gaagcttaca acttcactaa aaatcttgct gctgaaggcg gaaaaatcct tttcgtcgga 1422661 acaaaaaaac aagctcaaga ttctgttaaa gaagaagctc aacgctctgg catgtactat 1422721 gtcaaccaac gctggttggg cggtacatta acaaacttcg aaacaatcca aaaacgtatt 1422781 aaacgtctta aagacattga aaaaatgcaa gaaaacggta cgtttgatgt acttcctaaa 1422841 aaagaagtcg ttcaattgaa aaaagaatta gagcgtcttg aaaaattcct aggcggaatt 1422901 aaagatatga aggatcttcc tgatgcatta ttcatcatcg atcctcgcaa agagcgcatc 1422961 gctgttgcgg aagctcgcaa attaaacatc cctatcatcg gtatcgtaga tactaactgt 1423021 gatccagatg aaatcgatgt tgttatccca gcgaacgatg acgctatccg cgctgttaaa 1423081 cttctaactt ctaaaatggc agatgcaatc ttagaagcga agcaaggcga agaagaagcg 1423141 gaagttgctg aagaaactgc accagaaaca gaaacaacaa ctgcgtaacc tattcaaaag 1423201 gtgataagag ggactgcctt ttatcacctt ttttcaagaa aaatgtgtaa tatacatact 1423261 cttgtttaaa catataagga ggaatacaaa tggcaattac tgcacagcaa gtaaaagaac 1423321 tgcgtgaaaa aactggcgcg ggcatgatgg attgtaaaaa agcgttaact gaaactgacg 1423381 gagatatgga caaagcaatt gaccttttaa gagaaaaagg aattgcaaaa gcagcgaaaa 1423441 aagctgaccg tatcgcagca gaaggttcta ctcttattaa aactgacggc aacaaaggcg 1423501 ttatcctaga agtaaactct gaaactgatt tcgttgcgaa aaacgaaggt tttaaagagc 1423561 ttcttaacac tttagctgac caccttcttg caaacacgcc agctgatgtt gaagaagcaa 1423621 tgggccaaaa aatggaaaat ggctcaactg ttgaagagta catcacaagc gcagttgcta 1423681 aaatcggtga gaaaatcact cttcgccgct ttacagttct tacaaaagac gacagctctg 1423741 cattcggtgc gtaccttcac atgggcggcc gcatcggtgt attaactgtt ctcaacggta 1423801 caactgatga agaaactgcg aaagatatcg caatgcacgt tgctgcagtt aaccctcgtt 1423861 acatttctcg tgatcaagta tctgaagaag aaacaaatca tgagcgtcaa atcttaactc 1423921 agcaagccct ccaagaaggc aaacctgaaa acatcgtagc gaaaatggtt gaaggccgtc 1423981 tgaacaaatt cttcgaagaa atttgtctat tagaccaagc gttcgttaaa aacccagatg 1424041 aaaaagtgaa acaagttatt gcagcgaaaa acgctactgt tcaaactttt gtccgctatg 1424101 aagttggaga aggcatcgaa aaacgtcaag aaaactttgc tgaagaagta atgaaccaag 1424161 tgaaaaaata atggtgaaaa gatttcgcgg ctaagtcgcg tcttttcagg cagtataggg 1424221 gacacatttt gtgttcccta tttttaaaac tatatttaca aacctttttt tctcttgcat 1424281 aatagaaaac ggcaatgttt acacttggag gttatcatgg aaaaaccaaa atacaaacgt 1424341 atcgtattaa agcttagcgg ggaagcattg gcaggagaac agggaaatgg aattaacccg 1424401 actgtcattc aatccattgc aaagcaagtg aaggaaatcg ctgagcttga agtcgaagtg 1424461 gctgttgttg taggcggcgg caacttatgg cgcggaaaaa caggaagtga cctgggcatg 1424521 gaccgcgcga ctgctgacta tatgggaatg ctggcgacag taatgaattc gcttgctctt 1424581 caagacagct tggaaacact cggaatccag tccagagtgc aaacatccat tgaaatgaga 1424641 caagttgctg aaccgtacat aagaagaaaa gcgatacgcc acttagagaa aaaacgtgtc 1424701 gttattttcg ctgcgggcac aggaaaccca tatttctcaa ctgatacgac agctgcactg 1424761 cgggctgctg aaattgaggc agacgttatt ttaatggcta aaaataacgt tgacggtgtg 1424821 tataatgctg atcctagaaa agatgaatca gctgttaagt atgaatcact ttcttatctt 1424881 gacgttctta aagacggcct ggaagtcatg gattcaacag cttcctcttt atgcatggac 1424941 aatgacattc cgcttatcgt cttttctatt atggaagaag gaaatatcaa acgtgccgtt 1425001 atcggtgaat caatcggaac gatcgtgagg gggaaataac gtgtcaaaag aagtattaac 1425061 tcaaacaaaa gaaaaaatgg aaaaagcaat tgctgcttat cagcgcgaat tggctactgt 1425121 acgcgcaggc cgtgcaaatc catcattatt agataaagta acggttgaat attacggagc 1425181 gcagacacct ttaaatcagt tgtcttctat taacgtgcct gaagctcgta tgctcgttat 1425241 cacgccatac gataaaacag caatcggtga tatcgaaaaa gcgattttaa aagctgattt 1425301 aggtcttaca ccaacaagtg acggcaatat gattcgaatt gcaattccgg cactaacaga 1425361 agagagacgg aaagaattag tgaaagttgt aaaaaaatat gctgaagaag caaaagtagc 1425421 tgttcgtaac gttcgccgtg atgctaacga tgatctcaaa aaacttgaga aaaacggaga 1425481 cattactgag gatgaactgc gtgcttccac tgaagacgtt caaaaactga cagatgaata 1425541 tgtgtcaaaa attgacagtg tcacaaaaga caaagaaaaa gaaatcatgg aagtttaatg 1425601 aaaaactatg tacaatagat aatagtgaaa agaccctctc atgtttacag ggggtttttt 1425661 tgttaatact gttgattaca ttgattatca gcagggaatg taaccttttt gggtgacgga 1425721 ggaatctcat gctcaacata ctcaaaaatt ggaagaatca gcaaactgcg gcttccaact 1425781 tagaacgtta tacaaaagaa gacatactta agggagaaat tcccgaacac atcgccatta 1425841 tcatggatgg aaatggccgt tgggctaaaa aacgctctct tcccagaatt gcaggccacc 1425901 atgaagggat gaaggtggta aaaaggacca cgaagctcgc aaacgaatta ggtgtcaaag 1425961 tactgacatt gtatgcattt tcaacagaaa actggaaaag accgaaaatg gaggtcgatt 1426021 ttttaatgaa gcttccggaa gaatttttga atacgtatct tccagagctt gttgaggaaa 1426081 atgtacaggt tcggatcatt ggggatgaaa cggctttgcc ggcgcacaca ttacgtgcga 1426141 ttgaaaaagc tgtacaggac acggcgcaaa acgacggaat gatccttaat tttgctctta 1426201 actatggagg ccgtactgaa attgtcagtg ctgcaaaatc actcgcggaa aaagtgaagg 1426261 aaggctcttt gaatattgaa gacattgatg aatcgctttt ttctacttat ttgatgactg 1426321 aatctttgca ggatcctgaa cttttaattc gaacgagcgg cgagataagg ctgagtaatt 1426381 ttatgctatg gcaggttgcc tacagtgaat ttgtctttac tgacgtcttg tggcctgact 1426441 ttaaagaaga tcacttcttg caggcgttag gagagtttca gcagagaggc cggaggtttg 1426501 gcggaattta gaggatggtg gacatgaaac aaagaatttt gacaggtgtt ctggcagcaa 1426561 ttgtattttt atttttggtt attgtcggga aattgccgtt caccatatta atttatgcta 1426621 tgggcagtgt ggcgcttttt gaacttttac ggatgaaaaa gctgaagctg gtttcactgc 1426681 cgggtttgat cggtctttta ttattgtgga tgttcttatt accaagccag tattcgtttt 1426741 ttgaagcgga cgggatttcc aaaatggaaa tcgctttatt tgcggtactg ctattgctga 1426801 cttacacagt gttggtcaag aacaccttta cttttgatga agtcgggttt attacgcttg 1426861 cagcaattta catcggaatg tgttttcatt attttatcga aatcagaaat cttgaccaat 1426921 acggattaac atacattttt tatgcgtgtg ttgtcatttg gtccaccgat tccggtgcct 1426981 attttgtcgg taaatcgctt gggaagcgga aactgtggcc tgaaatcagt ccgaataaaa 1427041 cagtggaagg gtttgcaggc ggaattgtca tcgcacttgt attggcgacg atttttcagc 1427101 ttgttgcaca acttccgatc ccgtatatct atctgctgtt gatcacgctg tttttgtctg 1427161 tttttggaca actgggagat ttagtggaat ccgccttgaa aagacattac gatgtaaagg 1427221 attctgggaa tattcttccc gggcatggcg gtatattaga ccgttttgac agtttcttgt 1427281 ttgtcatgcc tttcttgtac tttctgcttg cccttttttc ataaaaaagt ctaatatgaa 1427341 tatgagactg atcatgcagc aataagaata ggagtagtgg caactttgaa aaatatttgt 1427401 cttttaggag caacaggatc aatcggcgaa cagactcttg atgtactgcg tgcacatcaa 1427461 gaccaatttc agctggtatc tatgtcgttt ggcagaaata ttgataaggc cgttccaatg 1427521 attgaggtct ttcagccgaa gtttgtctct gtcggtgatc tggatacata tcataaatta 1427581 aaacaaatgt ctttttcttt tgaatgccaa atcgggctgg gagaagaagg actgatagaa 1427641 gcagcagtga tggaggaggt tgacattgtt gtcaacgctt tgcttggaag cgtcggtctt 1427701 atcccgacat taaaggcaat tgaacagaaa aaaacaattg cgcttgcaaa taaggaaact 1427761 cttgtcactg cagggcatat agtaaaagaa catgctaaga aatatgatgt tccgctgctg 1427821 cctgttgaca gtgagcattc agccattttt caagctcttc aaggcgaaca ggctaaaaac 1427881 attgaacgcc tcatcattac ggcatccggc ggaagttttc gggacaagac gcgggaggag 1427941 ctcgaatcag taacggttga agatgcatta aaacatccaa actggtcaat gggtgcaaaa 1428001 attacaattg attcggctac aatgatgaat aagggattag aggtgatcga ggcacactgg 1428061 cttttcgata taccttatga acaaattgat gtggttttac ataaggagag catcatccat 1428121 tcaatggttg agttccatga taaaagtgtg atcgcacagc tcggaactcc ggatatgaga 1428181 gtccccattc aatatgcgct cacttatcct gaccgattgc cattaccaga tgcgaaaagg 1428241 cttgaattat gggaaatcgg cagccttcat tttgagaaag ctgattttga caggttccga 1428301 tgcttacaat ttgcttttga atcaggtaaa ataggaggaa caatgccgac agtgctaaat 1428361 gcggcaaacg aagtagctgt cgctgccttt ttagctggca agataccgtt tttggctatt 1428421 gaagactgta tcgaaaaggc actaacccgc catcaattac tgaaaaaacc gagcctggcg 1428481 gacattcaag aagtggacaa agatacccgg ggatacgtca attcaatact cacataaggt 1428541 ggtatgttcg tgaatacagt tatagcgttt atcattattt tcggaacgct cgttttcttc 1428601 catgaactgg gccatttatt gctagcccaa agagcgggaa ttctctgccg tgaatttgcg 1428661 atcggcttcg gtccaaagat tttttctttc aaaaaaaatg aaacagttta tacgatcagg 1428721 ctgcttccgg tcggcggatt tgttcgtatg gccggcgaag atccggaaat gattgaggtg 1428781 aaacccggat acacggtcgg gcttctgttt aataaggaag atcaagttga gaaagtcatc 1428841 atcaatcaaa aggaaaaata tccggatgct ttagtcattg aagtggaaac agcggatcta 1428901 gagcatgaca tgaagatcac cggttatgaa caggggaaag aggacgaact ttccagcttt 1428961 actgtcagcg aaacatcctt ttttattgta gacggagaag aagtgcagat tgcgccgtat 1429021 aatcgccaat ttggttccaa acctgtatgg cagcggatta aagcaattgc tgcagggccg 1429081 attatgaact ttattttagc ttacgtcatt ttagtgatgc ttgggctgat tcaaggcgta 1429141 ccgtcaaatg aacctatgct cgggcagctg acagacaatg gacgggcggc tgaagcaggg 1429201 ctaaaagaag gggattatat ccaaagcatt aacggagaga aaatgaggtc ttggactgac 1429261 attgtctccg ctgtaaaaga aaacccggag aaagaaatgg acgttgcagt aaaaagagat 1429321 aacaaaacgc ttcatatttc ggtgactccg gaagctgtta aagatgagaa caaaaaaaca 1429381 atcggacgtt tcggttccta tgcgccgact gaaaaaggcg tactctcagc ggttgcttac 1429441 ggcgcgacat caacagttga tgtcaccaaa gccattttaa ccaatctgag caaattagta 1429501 acaggccaat ttaaactcga tatgctgtca ggtcctgtcg gcatatatga catgacagac 1429561 caagtggcga aaacagggat cgtgaactta tttcagtttg cggcgttttt aagcattaac 1429621 cttgggattg tcaacctgct tccgattccg gcacttgacg gaggaagact gttgtttcta 1429681 tttattgaag cgattcgggg caaaccgatt aacagggaaa aagaagcatt tgttgtgttt 1429741 atcggagtag ctttcttaat gcttcttatg ctggttgtca catggaacga tatccagcgg 1429801 ctgtttttgt aaacgaaaag taaatcaatc agaggtgcga agaaatgaga caaagcttga 1429861 cgcttattcc tacgctccgt gaagttccag ctgatgccga agcaaaaagt catcagcttc 1429921 ttctgagagc aggatttatc agacagaata cgagcggggt atacagctat atgcctcttg 1429981 cgtataaggt gattcaaaac attcagcaga ttgttcgaga ggaaatggag aaaattgatg 1430041 ccgtagaaat gctcatgccc gcattgcagc aggcagagac atggcaggaa tcaggcagat 1430101 ggtatacgta tggtcccgaa ctgatgagac taaaagaccg tcatggccgt gaatttgctt 1430161 taggggcaac gcatgaagag gttatcactt cgcttgttcg cgatgaggtt aaatcttata 1430221 agcgtctccc tctgactctt tatcaaattc agtctaagtt cagagatgaa aaacgtcctc 1430281 gcttcggttt gttaagaggc cgcgaattta ttatgaagga tgcgtactct ttccatgcat 1430341 ctgcagagag cctggatgaa acgtatcaaa aaatgtacga ggcctattct aatatttttg 1430401 cccgctgcgg cattaatgta agacctgtta tcgctgattc aggcgcaatg ggaggaaagg 1430461 atacgcacga atttatggca ctttctgcga tcggagagga tacgattgcg tattctgatg 1430521 aatcacagta cgcggctaat atcgagatgg ctgaagttct tcaccaggaa gttccttcag 1430581 atgaagagcc taaagctcta gagaaggttc atacgcctaa cgtgaaaaca atcgaagaac 1430641 tgactgcgtt cttacaggtt tcggctgaag cgtgcattaa gtcagtattg tttaaagctg 1430701 atgaccgttt tgtcttagtg cttgtaagag gggatcatga agttaacgat attaaagtga 1430761 aaaacttgct tcatgcagaa gttgtagagc ttgctacaca tgaagaggtc attcagcagc 1430821 tcggaacaga gccaggcttt gtaggccctg tcggtattca tcaggatgtg gaagtatatg 1430881 ccgatcaagc tgtgaaagca atggttaatg ctgttgccgg ggcaaatgaa ggagatcatc 1430941 attataaaaa tgtcaatgtg aatcgtgacg cgcaaattaa agaatttgct gatcttcgtt 1431001 ttattaaaga aggtgatcct tcaccagacg gcaagggaac gatccgtttt gctgagggaa 1431061 tcgaagtcgg acaagtcttt aagctcggaa cacgctattc agaagcgatg aatgcgacat 1431121 atttagatga aaacggacgc gcgcagccaa tgctgatggg ctgttacgga atcggtgtgt 1431181 caagaacgct ttctgctatt gctgaacagc atcacgacga aaaaggctta atatggccaa 1431241 aaagcgttgc gccgtacgat cttcatattc ttgctttgaa catgaaaaac gatgggcaaa 1431301 gagagcttgc tgaaaagctg tatgccgatt taaaagcgga aggctatgaa gtgctctatg 1431361 atgaccgtgc tgagcgtgcc ggcgtaaaat tcgctgattc agatttaatc ggccttccaa 1431421 tccgcatcac tgtcggaaaa cgagctgacg aaggaatcgt cgaagtgaaa attcgtcaaa 1431481 ctggtgagtc aactgagatt tcagtagacg aattatctgc gtttatcagc aagcagtaat 1431541 caccataacg atttatcaaa aaacatgtta aaatagaaat aatagaaggt acctcattgc 1431601 ctgaggtacc ttcacttatg atgtttttag ggagggatac tgtcttaatg gaacagttat 1431661 cagtaaacag aaggcagttt caaattcttc tgcagcagat taatatgaca gatgatacct 1431721 tcatgacata ctttgaacat ggcgagatta aaaagctgac aattcacaaa gcttctaagt 1431781 cttggcattt tcattttcaa tttaaatctt tgctgccttt tcaaatatat gacacattaa 1431841 caacgaggct gacgcaatcg tttgcccaca tagcaaaagt gacatcttca attgaagttc 1431901 aggatgccga ggtcagtgaa agtatcgttc aagactactg gtcacgctgc attgaagaac 1431961 tgcagggcat ttcgccgccg attatcagtc ttttaaacca gcaaaaaccg aagctgaagg 1432021 gcaataaact gattgtcaaa accaaaacag atacagaagc ggctgcgcta aagaacaaat 1432081 acagttccat gattcaagca gaataccgtc aatttggctt tccggatctt cagcttgatg 1432141 ctgaaatatt tgtatccgag caagaagttc aaaagtttcg ggagcaaaag cttgcggaag 1432201 accaagagcg ggctatgcag gccttgattg aaatggagaa gaaagataaa gaaagtgatg 1432261 aagaccaagc accatctggt cctcttgtta tcggttatca aattaaagat aacgaggaaa 1432321 tccgaacact tgacagcatc atggacgaag aacggagaat tacggtccaa ggttatgtgt 1432381 ttgatgtgga gacgcgcgag ctgaagagcg ggcgcacgct gtgtatcttc aaaattacag 1432441 actatacaaa tagtattttg atcaaaatgt ttgcacgtga aaaagaagat gcggcgctga 1432501 tgaagtctct gaaaaaagga atgtgggtaa aagcacgcgg aagcattcaa aatgatacat 1432561 ttgtcagaga ccttgtcatg atcgcaaatg acgtaaacga aataaaagca aaaacccgtg 1432621 aagattcagc acctgaagga gaaaaaagag tggaattgca tcttcattcc ccaatgagcc 1432681 aaatggatgc tgttacgggt atcggaaagc ttgtcgaaca ggcgaaaaaa tgggggcatg 1432741 aggccatcgc tttgaccgac catgctgtcg ttcaatcctt ccctgatgcg tattctgcgg 1432801 ccaaaaagca tggaattaaa atgatttacg ggatggaagc gaatctcgtg gatgatggcg 1432861 tgccaattgc ttataatgcc gcacatcgtc tgctcgaaga agaaacatat gttgtttttg 1432921 acgttgagac gacaggattg tctgctgtat acgataccat tattgagctg gctgcagtaa 1432981 aagtaaaagg cggagaaatt attgataaat ttgaggcgtt tgcgaacccg catcgtccgc 1433041 tttccgccac aatcatagag ctgacaggga tcacagatga tatgctacaa gacgctccgg 1433101 atgtcgtaga tgtaataaga gatttcagag aatggattgg cgatgatatt cttgtcgctc 1433161 ataatgcaag ctttgatatg ggattcttaa atgtagccta taaaaaactt cttgaagtcg 1433221 aaaaagctaa aaacccagtc attgatacgc ttgaacttgg acgttttctc tatccggaat 1433281 ttaagaacca ccggttgaac acactttgta aaaagtttga tatcgagctc acacagcatc 1433341 accgtgcgat ctatgatact gaggcaaccg cttatttgct tctgaaaatg ctgaaagacg 1433401 cagctgaaaa aggtattcag taccatgatg agttgaatga aaatatgggt cagtccaatg 1433461 cttatcaaag atcaagaccg tatcatgcaa cattacttgc cgtgaacagc acgggactta 1433521 aaaatttatt taagcttgtg tcactttctc atattcatta tttttacaga gtgccgcgta 1433581 ttccgagatc tcagcttgag aaatacaggg aagggcttct gatcggttct gcttgtgaca 1433641 ggggagaggt ttttgaggga atgatgcaaa aatcgcctga agaggtggaa gatatcgcgt 1433701 cattctatga ttaccttgag gttcagccgc ctgaagtgta tcgtcacttg ctggagcttg 1433761 aactggtccg tgatgaaaaa gcgctgaaag aaattattgc gaatatcacg aagctggggg 1433821 aaaagcttaa taaaccggtt gttgctacgg gaaatgttca ttacttgaat gatgaggata 1433881 aaatctacag aaagatttta atatcctcac aaggcggggc aaatccgctg aataggcatg 1433941 aactgccgaa agtgcatttc agaacgacag acgaaatgct tgaagctttt tctttcttag 1434001 gtgaagaaaa agcgaaggag atcgtagtca ccaataccca aaaggttgct tctttagttg 1434061 atgacatcaa gccgattaaa gatgatttat atacgccgaa aatcgaaggc gctgatgaag 1434121 agatcagaga aatgagctat cagcgtgcaa gaagcattta cggggaagag ctgcctgaaa 1434181 ttgtcgaagc gcggattgaa aaagagttaa agagtattat tggccacgga tttgctgtta 1434241 tttacttgat ctctcacaaa cttgtaaaac gttcactaga tgacgggtat ctcgttggtt 1434301 cccgtggttc cgtaggatct tcattagttg cgacacttac tgagattact gaggtaaacc 1434361 cgctgccgcc gcactatgtt tgtcctgagt gccagcattc tgagttcttt aatgacggtt 1434421 ctgtcggttc tggttttgac ctgcctgaca agacatgccc tcattgcgga acgcctttga 1434481 aaaaagacgg ccatgatatt ccatttgaaa cgttcttagg atttaaaggg gacaaagtac 1434541 ctgatatcga tttgaacttc tcaggggaat atcagccgca agcacacaat tacacaaaag 1434601 tattgttcgg agaagacaat gtatatcgtg cgggaacaat aggcacggtg gcagaaaaaa 1434661 cagcctacgg ttatgtaaaa ggctatgccg gagacaacaa tcttcatatg cgcggtgccg 1434721 aaatagatcg gctcgtacag ggatgcacag gtgtaaaacg tacaactgga cagcaccctg 1434781 gcggtattat cgtagttccg gattatatgg atatttatga tttttcaccg atccagttcc 1434841 cggcagatgc cacaggttca gagtggaaaa cgactcattt tgatttccac tccatccatg 1434901 acaacctgtt aaaacttgat attctcggac acgatgaccc gactgttatt cggatgcttc 1434961 aagacttaag cggaatagat ccgaaaacaa ttccgacgga tgatcctgaa gtgatgaaga 1435021 tcttccaggg aaccgaatca ctcggtgtga ctgaagaaca gattggctgt aaaacgggca 1435081 ctcttggaat tcctgaattc ggaacccgat ttgtccggca gatgcttgaa gatacaaagc 1435141 cgaccacttt ttctgagctc gttcagattt caggcttgtc tcacggaact gatgtatggc 1435201 ttggcaatgc acaggagctc atccacaata atatttgtga gctgagtgag gttatcggct 1435261 gccgtgatga cattatggtt tatttaatct atcaaggcct tgagccgtcc cttgccttta 1435321 aaatcatgga attcgtgcgt aaaggaaaag gattaacgcc tgaatgggaa gaagaaatga 1435381 aaaataacaa tgtcccagac tggtatattg attcctgtaa aaagattaaa tacatgttcc 1435441 cgaaagccca cgccgcggca tatgtcttaa tggcagtccg cattgcttac tttaaagtgc 1435501 atcatgctct tttgtattat gcggcttatt ttaccgttcg tgcagatgac tttgatattg 1435561 atacaatgat caagggctct acagcaatca gagcggtaat ggaggatata aacgctaaag 1435621 gacttgatgc ttcaccgaag gaaaagaacc ttctgactgt tttagaatta gcgcttgaga 1435681 tgtgtgagag aggctattca ttccaaaaag tcgatttata tcgctccagc gccacagagt 1435741 ttattattga cggcaacagt cttattccgc cgtttaactc tattccaggg ttagggacga 1435801 acgctgcttt gaacattgta aaagctcgcg aagaaggcga attcctctca aaagaagatt 1435861 tgcaaaagag agggaaagta tcaaaaacga ttttagagta cttagatcgc catggctgtc 1435921 tggagtcact gcctgatcaa aaccaattgt cactgttcta atatggaaag cagaatttct 1435981 cagaaattct gcttctatgc atacataagc gcaaaaagtg ccatcgtaat attagagttt 1436041 ctgtcacttg cttaggtatg aaggtaagcg tatatccatt tgcaataaaa atatggttat 1436101 ggtatagttt tattggaaat gctaacgatt accgaggcaa agagtgggga aacccgctct 1436161 tttgtattga acaggagaat tttgtctcga catgttcatc gtttactttt tagcccctgc 1436221 tcttttgaag cagggttttt atgcagagtg acgagacgaa tatgagatcg acagcacaag 1436281 gaggaagaac atgagcaaaa aagtgactga caccgttcaa gaaatggctc agccaatcgt 1436341 agacagcctt cagctggaac tcgttgacat tgaatttgtc aaagagggcc aaagctggtt 1436401 ccttcgcgtg tttattgatt ccgatgacgg tgtggatatt gaggaatgtg ccaaagtaag 1436461 cgaagcttta agcgaaaagc ttgatgaggc agacccaatc agccaaaatt actttcttga 1436521 agtctcatct ccaggagctg agcgtccgct aaagaaaaaa gccgatttcg aaaaatcact 1436581 aggaaaaaac gtatacatta agacgtatga gcctattgac ggcgtaaaag tgtttgaagg 1436641 tgaactggct gaatttgatg gacaaacagt gacagttgag atcacgatca aaacaagaaa 1436701 gaaacggatc aatattccgt atgaaaagat agctaatgca agattagctg ttacattcta 1436761 atgaatacaa atgttttaag gggggagacc gttaaatgag cagtgaatta ttagatgctc 1436821 tcacgattct tgaaaaagaa aaaggcatca gtaaagaaat tatcatcgaa gcaatcgaag 1436881 ctgcgttaat ttctgcttat aagcggaatt ttaatcaagc gcaaaatgta cgggtggatc 1436941 taaaccgtga aactggctcc atccgtgtat ttgcaagaaa agatgtcgtt gacgaagtat 1437001 acgaccagag attagaaatc tcaattgaag aggcacaggg catccatccg gaatatatgg 1437061 tcggcgatgt cgtcgaaatc gaagttacac ctaaggattt cgggcgcata gctgctcaaa 1437121 cagcgaagca ggtcgtcaca cagcgtgtgc gcgaagctga gcgcggtgtg atttattctg 1437181 aatttatcga ccgtgaagaa gacatcatga cagggatcgt ccagcgtctg gacaataaat 1437241 ttatctacgt gtctttaggc aaaatagaag ccttgctgcc ggttaatgag caaatgccga 1437301 atgaaagcta caagccccat gaccgcatta aggtatatat cacaaaagta gaaaaaacaa 1437361 cgaagggtcc gcagatttat gtgtcaagaa cacatccagg cctgttaaag cgtttgtttg 1437421 aaattgaagt gcctgaaatt tatgatggaa ctgtcgagct aaaatctgtt gccagagaag 1437481 ccggcgaccg ttcgaaaatt tctgttcgca cagatgatcc tgacgttgat cctgtcggtt 1437541 catgcgtagg gcctaaaggc cagcgtgtgc aagcaatcgt caatgaatta aaaggtgaaa 1437601 aaattgacat tgtcaactgg tccagtgatc ctgtagaatt tgtcgcgaat gcgctcagcc 1437661 cttccaaagt gcttgatgtc attgttaatg aagaagaaaa agcgacaact gttattgttc 1437721 ctgattacca gctgtctctg gcaattggaa aaagaggaca aaacgcacgc ttagctgcta 1437781 aactgacagg ctggaagatt gatattaaga gcgaaacgga cgcaagagaa cttggaatct 1437841 atccgagaga acttgaagaa gatgatgagc cgctctttac ggagcctgaa actgctgaat 1437901 cggatgaata agaggtgact ttaggtgaat aaacacaaaa agatcccatt acgcaaatgt 1437961 gtagtgactg gtgaaatgaa gcctaaaaag gaactgatcc gagttgtacg gtcgaaagaa 1438021 ggcgaaatct cagtagaccc gaccggaaaa aagaatgggc ggggtgctta tttaacgctg 1438081 gataaagagt gcatcttagc agcaaaaaag aaaaacactt tgcaaaatca atttcaatca 1438141 caaatcgatg accagatttt cgatgaattg ctggaactgg cggaaaaggt gaaaaaataa 1438201 aatgtctgga atggaatggt ttcccttgct gggtctggcc aatcgagctc gtaaggtcgt 1438261 gtcaggcgaa gacttggtaa taaaagaaat caggaatgcg cgtgcaaagc ttgtcctgct 1438321 tacagaggat gcatcatcta acacagcaaa aaaagtaact gacaagtgca attattataa 1438381 agtcccttat aaaaaagtcg agagtcgcgc ggttcttgga cgctctatcg gtaaagaagc 1438441 ccgtgtcgtt gtcgccgtca ctgaccaagg ttttgcgaat aagctgatca gcttgctcga 1438501 ttaatatttt tgggggtgaa cgaatggcta aaatgagagt atacgaatat gcaaaagcgt 1438561 taaatgtttc aagtaaggaa attttgaccg cactgaagaa catggattta gaagtgaata 1438621 atcacatggc catgcttgaa gaaaaggcca ttaaaaagct agatgccaaa tataaaaaag 1438681 gcggcgcagc tgctaaatct caaaagccag cagaaacgaa caaaaacaaa cagccacaag 1438741 gggttaatca gcaatcagct ggaaatcaac caaataaaat tcgagacgga aagaagaatg 1438801 acgtgcagaa taatcaattt aacaaaaaca agaagaataa caacaacaaa aaaaataaac 1438861 gcaacaacaa caataataaa aaccaacatc agcaaaagcc tgtaaagccg aaaaaagagc 1438921 ttcctgagaa aattacattc tctggcactt taacagttgg cgcacttgct gaagagcttg 1438981 gcaaagagcc ttcagaactc attaaaaagc tgatgcttct tggcgtaatg gcaaccatta 1439041 accaagagct tgataaagac acaatcgaac tcattgcatc agaatatggt gttgaaacag 1439101 aagaggtcat tgtgcttgaa gaaacagagc tggaaaaata cgaagagcct gataatgaag 1439161 aggatcttga aattcgtcct cctgtcgtga caatcatggg ccacgttgac catgggaaaa 1439221 caacgcttct tgacagcatc cgtaaaacaa aggttgttga aggggaagca ggcggaatca 1439281 ctcagcatat cggcgcttat caaattgaag agaacggcaa gaaaatcacg ttcttggata 1439341 caccgggcca cgccgcattt acaacaatgc gcgcacgcgg tgcagaagta actgatatta 1439401 cgattcttgt cgtagctgcc gatgacggtg tcatgccgca aacagttgaa gcgattaacc 1439461 atgcaaaagc agcagaggtt ccaatcatcg ttgctgtgaa taaaatagat aaagaatccg 1439521 caaaccctga ccgtgtaatg caagaactga cggaatacgg acttgtccct gaagcttggg 1439581 gcggagaaac catttttgtg ccgctttccg ctttaactgg aaaaggcatt gatgagctcg 1439641 ttgaaatgat tttgcttgtc agtgaggtag aggaactgaa agcgaatccg aatcgtcagg 1439701 caaaaggaac ggttattgaa gctgaactcg ataaaggcag agggtcagtc gcgacgttgc 1439761 tcgtacagac tggaacactg catgtcggtg atccgatcgt agtcggcaat acatttggcc 1439821 gtgtccgtgc aatggtcaac gacattggcc gccgtgtgaa aactgccggc ccgtcaactc 1439881 cggttgaaat taccggtttg aatgatgtcc ctcaagcggg agaccaattc cttgtcttta 1439941 aggatgaaaa aacagctcgt tctgtcggtg aagcccgtgc ttcgaaacag cttgaagagc 1440001 agcgcagcga taaagcgaag ctcagtcttg atgatttatt tgagcaaatt aagcaaggtg 1440061 atgtaaaaga catcaacctc atcgtaaaag ctgacgttca aggatctgct gaagctttaa 1440121 cggctgcact tcaaaaaatt gaagtagaag gcgttaaagt gaaaatcatc catacaggcg 1440181 ttggtgcgat tactgaatca gacattatct tggcatctgc ttccaatgca attgttatcg 1440241 ggtttaatgt gagaccggac ggaaatgcta agagtacggc tgaagctgaa aatgtagata 1440301 ttcgacttca ccgtatcatt tacaaagtaa tcgacgagat tgaagctgcc atgaaaggta 1440361 tgcttgatcc tgaatatgaa gaaaaagtaa ttggtcaagt agaagtacgc caaacattca 1440421 aagtatctaa aatcggtaca attgccggcg gatatgttac tgaaggaacc attacgcgcg 1440481 acagcggcct ccgtttaatt cgtgacggcg tcgtcatctt tgaaggcgaa gtagatgttc 1440541 tgaaacgctt taaagacgat gtgaaagaag tttcacaagg ctatgaatgt ggtattacaa 1440601 ttaagaaata caatgacatt cgtgaaggtg acatccttga agcgtttgtc atgcaagaaa 1440661 ttgaaagaac gtgatcggat ttgcggagtg tgaatgcatc atttatgatg caggatcgct 1440721 aaaagaaaag cgtgccgttc tgaagcggat tttaaccagg gttcaaaaca agttcaatgt 1440781 ttcgatttcg gagattggct atcaggacac ctggcaaaga accagcttcg gaatcgccgc 1440841 tgtttcttcc tctcgcgttc aaacagaaaa agaactgcag cgcgtcctag cgtttatcga 1440901 ttcttttcct gaaattgaac ggacgatcac taggacagag tggttttaac ttagaggtga 1440961 ttgaattgag tatgagagca aaccgtgtcg gcgagcaaat gaaaaaagaa ctcggtgata 1441021 ttatcagccg caagctgaaa gacccgagaa ttggttttct gacagtaacg gatgtacgtg 1441081 tatcaggtga tttgcaaatt gcaaaggtgt atatctcggt tctcggtgac gagaaaaaac 1441141 gggaagaagc gctgaaaggg ctggcaaaag cgaaaggatt tatccgatcc gaaatcggca 1441201 gccgcatcag acttcgaaaa acgcctgaaa ttgaatttga gttcgatgaa tcaatcgatt 1441261 acgggaatcg gatcgaaaca ctgattcacg aattacattc agagaaacca tctgaataaa 1441321 aaaagagagg ataggcgtat atcgtctgtc ctctttcttc gtttataaga aaaaaactca 1441381 aaagaaggag tgaaaggcaa atggttaacg gagttctcct tttacataaa cctgttggca 1441441 tgacatcgca cgactgtgtc atgaagatcc gaaagctgtt aaaaacaaaa aaagtaggac 1441501 atacaggaac gctcgatccg gaagtatcag gcgtgcttcc gatttgtgta ggaagagcga 1441561 caaaaatagt cgaatactta actgaaaaat ctaaaacgta tgatgcagaa ataacattgg 1441621 gcttttcaac cacaacagag gatcaaaccg gagaaacggt ggaaacaaag cctgtcaatc 1441681 acgacattga taaagcggat gtagaaaagg ttttaaacag tttaaagggg aaacaagaac 1441741 aaattccgcc catgtattcc gctgtaaaag taaacggcaa aaaattatac gaatacgcaa 1441801 gagcagggat tgaagtagaa cgtccgaaac gtatgataac cattgaagac attgccctga 1441861 caacagagat taaacatcat ggagaaaccg caagcttccg gtttacagtg acttgctcca 1441921 aagggaccta tgtaaggacg ctggcggtca tgatcggaga aaagctcgga tatccggccc 1441981 atatgtctca tttaatccgt acggcatccg gagatttttc tctcgacgaa tgctttactt 1442041 ttgatgaact cgaagcacag gcccaatccg gaaccgtgga agagcataca gttcctattg 1442101 aacgtgcgct caatcatttg ccgaaatgga tcataagtga tacattagct aagaaagtag 1442161 aaaatggggc tttgcttgag acgcccgagc agttttctga aatgacaagt ggagaccgta 1442221 ttgccgtctt tactgaatcc ggaacctgct tggcgatcta tttccctcat cctgcaaaaa 1442281 aagggctgtt aaagccggca aaagtattga tgcaaaaaag cgaacaatag aaaaaaggtg 1442341 accgttctgt gaagacgata catattacac atcctcatca tttaataaaa gaggagcagg 1442401 caaaatcagt gatggcgtta ggttattttg acggcgttca tctcgggcat caaaaggtaa 1442461 tcggcacagc gaagcaaata gccgaagaaa aaggtctgac attagctgtg atgacctttc 1442521 atccccatcc ttctcacgtg ttgggcagag ataaggaacc aaaggatctg attacgcctc 1442581 ttgaagacaa aataaaccaa attgaacaat taggcacaga agttctgtat gtcgttaaat 1442641 ttaatgaagt gtttgcttct ctttctccta agcagtttat agaccagtat attatcggcc 1442701 ttaatgtgca gcacgcagtg gcaggctttg actttacgta cggcaaatac ggcaagggaa 1442761 caatgaagac catgccggat gatttagacg gaaaagctgg gtgcacaatg gtagaaaaat 1442821 taacggagca ggataaaaaa atcagttctt cgtatatccg taccgcgctt caaaacggag 1442881 atgttgaatt ggcgaatgtc ttgcttggac aaccttattt tattaaagga attgtcattc 1442941 atggtgataa aagagggcgg accatcgggt ttccgacagc gaatgtcggt ttaaataaca 1443001 gctatatcgt tccgcccaca ggtgtatatg ccgtaaaagc ggaagtgaac ggcgaagttt 1443061 acaatggcgt ttgcaatatt ggctataagc caacgtttta tgaaaagcgc cctgaacagc 1443121 cttccatcga ggtcaatctg tttgatttca atcaagaggt atatggagcc gctataaaaa 1443181 tcgaatggta caaacggatt cggagcgagc ggaaattcaa tggcatcaaa gaattaactg 1443241 agcaaattga gaaagataag caggaagcca tccgttattt cagcaatttg cggaaataac 1443301 ttgcaacgca cgcaaatttt attctaaaat atttgcatat aggcacgatt tttagtatga 1443361 tagttttcgt agtcttaaaa ccattgcttg gcaatccgaa gtcaccgacg gttgctaggt 1443421 aactggggct aaatatgatt tggaggtgaa acaggatggc aattactcaa gagcgtaaaa 1443481 accaactcat caatgagttc aaaacacacg aatctgatac tggatctcca gaagttcaga 1443541 tcgctatcct aactgactca attaacaact tgaacgagca tttacgtact cacaagaaag 1443601 accaccactc acgtcgcggt cttcttaaaa tggtaggtaa gcgtcgtaat cttcttacgt 1443661 atctgcgtaa taaagacgta actcgttacc gtgagttaat taacaaacta ggcttacgtc 1443721 gataatcgta aaaagcggga ggattcccgc ttttttatcg tattaaagcg aaatttctta 1443781 taacaaatca ttgaaatcct tttacatact actttgacat tgatatgttc aattcatttc 1443841 gttcataata ggagtaattg attatttcac acaacgaaga gaggagttcg taattgtatg 1443901 ggacaagaaa aacatgtctt taccatagat tgggccggaa gaacgcttac cgttgaaacc 1443961 ggccagcttg ccaaacaggc aaatggtgct gtgatgatcc gctacggtga tacagcagta 1444021 cttagtacag caaccgcttc aaaagaacct aaaccgcttg atttcttccc tcttactgta 1444081 aactatgaag aaagattata tgcggtaggg aaaattccgg gcggatttat taaaagagaa 1444141 ggacgtccaa gtgaaaaagc ggttcttgcc agccgtttaa ttgaccgtcc gatccgtcct 1444201 ttgtttgccg atggattccg taatgaagtt caagtcatca gcattgtcat gagtgttgac 1444261 caaaactgct cttcagaaat ggctgccatg ttcggttcat ctcttgcact ttctgtatcg 1444321 gatattccgt ttgaaggacc gattgcaggg gttactgtcg gacgcattga tgatcaattt 1444381 atcattaacc cgacagtcga tcagcttgaa aaaagcgata tcaatcttgt cgttgccggc 1444441 acgaaagatg cgattaacat ggtagaagcg ggagcggacg aagttcctga ggaaatcatg 1444501 cttgaggcca ttatgttcgg ccatgaagag attaaacgcc tgattgcatt ccaagaagaa 1444561 attgttgcag cagtcggcaa agagaaatct gaaattaagc tctttgaaat tgatgaagag 1444621 cttaatgaaa aagtaaaagc tttggcagaa gaggatctgc tgaaagccat ccaagttcat 1444681 gaaaagcatg cccgtgaaga tgccattaac gaagtgaaga acgcagttgt ggcaaaattc 1444741 gaggatgaag aacatgatga agacacaatc aagcaagtga agcagatttt atccaagctt 1444801 gtgaaaaatg aagttcgccg cctgattact gaagagaaag taagaccgga cggccgcggt 1444861 gtcgatcaaa tccgtccgct ctcttcagag gttggcctct tgccaagaac gcacggttca 1444921 ggtctattta caaggggaca aactcaggcc ctcagcgtat gtacgctagg tgctctggga 1444981 gatgtgcaaa tccttgacgg cttaggtgtc gaagagtcga aacggtttat gcatcattac 1445041 aacttcccgc aattcagcgt tggggaaaca ggaccgatgc gcggaccggg acgtcgtgaa 1445101 atcggacacg gagcactggg tgagcgtgcg cttgagccag ttattccgtc tgaaaaagac 1445161 ttcccttata ctgtccgtct tgtttcagaa gtgcttgaat caaacggttc tacatctcaa 1445221 gcaagcattt gcgcaagcac acttgcaatg atggatgccg gtgtaccgat taaagcgcca 1445281 gttgctggta ttgcgatggg tcttgtcaaa tcaggcgaac attacactgt cttgactgac 1445341 atccaaggca tggaagacgc gctcggagat atggacttta aagtagcggg aactgaaaaa 1445401 ggcgtaacgg ccctgcaaat ggacattaaa attgaaggcc tttccagaga gattcttgaa 1445461 gaagcgcttc agcaggcgaa aaagggcaga atggaaatcc tcaacagcat gcttgcaaca 1445521 ttaagcgaat caagaaaaga gctttctcga tatgcgccta agatcttaac aatgaccatt 1445581 aatcctgata aaatccgcga tgtcatcgga ccaagcggga aacaaatcaa taagatcatc 1445641 gaagaaaccg gtgttaaaat tgatattgag caggacggca caatctttat ttcctctaca 1445701 gatgaaagcg gcaaccaaaa agcgaaaaaa atcatcgaag accttgtgag agaggttgaa 1445761 gtcggccaac tttacctagg taaagtgaaa cggattgaaa aattcggggc tttcgttgaa 1445821 attttcagcg gaaaagacgg tttggtgcac atttcagagc ttgcgcttga acgcgtaggg 1445881 aaagttgaag atgttgtgaa aatcggagac gagattcttg tcaaagtcac tgaaattgat 1445941 aaacaaggac gagtgaattt atcccgcaaa gcggtgctcc gtgaagagaa agaaaaagaa 1446001 gaacaacaat cttaaatgaa aacataaaag gagcctggga gacccggctt ctttattttg 1446061 aagcttttca aaagcaggcg ggttctacct tgtccttctc cttcataatg tgaggtgagg 1446121 gggggacaga acatgtacaa aaaatttgta ccgtttgccg tttttttatt tctttttttt 1446181 gtctcatttg agatgatgga aaatccgcat gcacttgatt atataggggc aatgaaaaaa 1446241 gatacggtga ctgtcacggc gtcaaaagac ccgttatatg aagaattgct tcaaaaagcg 1446301 ccggagtacg aagttaagcc ccagaatgca agaattgata aagtgtggaa aagcattcca 1446361 ggctacaatg gattaaaggt caatattgaa caatcatata aaaaaatgaa acagcatggt 1446421 aagtttcggg aaaaagattt ggtgtacagt caagtaaaac caagtgttca tcttgagtca 1446481 cttcagcctg agcctattta taaaggaaat cctgacaaac cgatggtggc ttttttaatc 1446541 aatgtggcat ggggaaatga gtatttggaa aaaatgcttc ctattctgca aaagcaccag 1446601 gttaaagcta cgttcttttt agaaggcaat tgggtgagaa acaatgtaca gctcgctaag 1446661 aagattgcaa aagacggaca tgaaatcgga aatcattcat acaatcatcc ggatatgagc 1446721 aaactgacta caggaagaat ttccgagcag ctcgacaaga ctaatgaaca aatagaacaa 1446781 acgatcggcg ttaagccaaa gtggttcgct ccgccaagcg gaagtttcag aaaagcggtt 1446841 atcgacattg cagcagagaa acagatggga acagtcatgt ggacagttga tacaatcgat 1446901 tggcaaaagc cggctccgtc tgtacttcag acgagagtgt taagcaagat acataatggt 1446961 gccatgattt taatgcatcc gactgaccct acggcggaaa gtcttgaagc gctgattaca 1447021 cagataaaag acaaaggata tgcgcttgga acagtcactg aactaatgga tgaaacaaga 1447081 ctattgaagt aacagatgaa ggcagcttgt ctttgaatag gaggaacaaa tttgattaaa 1447141 cgatatacgt gtcaaaatgg tgtaagaatt gtgctggaaa ataacccgac agtccgttct 1447201 gttgcgatcg gcgtatggat cggcacaggt tcgagacatg aaacgccgga gataaacgga 1447261 atttctcact ttttagagca catgttcttt aaagggacga gcacaaaatc tgcacgcgag 1447321 atagcagaat cttttgatcg tattggcggc caggtcaatg cgtttacttc aaaggaatat 1447381 acctgctact atgcaaaggt gcttgacgag catgcgaatt acgcgctgga cgtattagca 1447441 gatatgttct ttcattcaac gtttgatgaa aacgagctga aaaaagagaa aaatgtagta 1447501 tatgaagaaa ttaaaatgta tgaagatgcg ccggacgaca ttgtacatga tttattgagc 1447561 aaagccactt acggcaatca ttctttaggc tacccaattt taggaacgga agaaacgctt 1447621 gcttccttta acggtgactc tctcagacaa tacatgcatg attattatac gccggaccga 1447681 gtggtgattt cggtagcggg caatatatct gacagtttta tcaaagatgt agaaaaatgg 1447741 ttcgggtcat acgaggcgaa aggcaaagcg acaggccttg agaagcctga gttccacacg 1447801 gaaaaactga cgagaaaaaa agaaacagag caggctcatt tgtgccttgg atttaaaggc 1447861 ttagaggttg gccatgaacg tatttatgat ttaatcgtcc tcaacaatgt gctcggaggc 1447921 agcatgagca gccggctgtt ccaagatgtg cgtgaagata aaggacttgc ttattctgtt 1447981 tacagctatc acagctcata tgaggacagc ggaatgctaa cgatttacgg cggaacgggt 1448041 gcaaatcagc ttcagcagct gtcggaaaca attcaagaaa ccctggccac attaaaacgt 1448101 gacggcatta cctcgaaaga actggaaaac agcaaagagc aaatgaaggg aagcttaatg 1448161 ctgagcttag aaagcacaaa cagcaaaatg agccgaaacg gaaaaaatga actgctgctc 1448221 ggcaaacata aaacattaga tgaaattatc aatgaattaa acgccgtgaa cttagagcgt 1448281 gttaatggcc ttgccagaca attgtttacc gaagactatg cattagcact tatcagccct 1448341 tccggcaata tgccgtctta aaaaggaaag cctgccccat aatggagcag gcatttttta 1448401 atccctttca tcatacatag tacaaggggg tgacagacat gcggctcagt gaattatcgg 1448461 gaaaggaaat tgtagacatc aaaagagctg aacggctcgg agtgctcggc cagaccgatt 1448521 tggaaatcaa tgaacaggat ggacagatta cagcactcct cattcccaca gttaagtggt 1448581 ttggtttgag aaagcaaggt catgacattc gtgtcccatg gcaccatatt caaaagatcg 1448641 gttcagatat gattatatta gatgtacctg aggaaatgcc tcctcgacaa gagtaaatag 1448701 cccaattgac tgtgaagcgg gctctaaaga aaacatctga aacatcggct gccggagccg 1448761 atgttttttt atatggaaaa agcgcatctt ttatattcac cggtatttcc ttttgatcat 1448821 aagatgaagg ggagcttaac aactagagat ccagtatata caaagaaggt gaacgtttag 1448881 aatgttaacc ggattgaaaa ttgcagttat cggcggtgac gcaagacagc tcgaaattat 1448941 aagaaagctc actgaacagc aggctgacat ctatcttgtc ggttttgacc aattggatca 1449001 cggttttacc ggggcagtaa aatgcaatat tgatgaaatt ccttttcagc aaatagacag 1449061 catcattctt ccagtatccg cgacaacagg agaaggtgtc gtatcgactg tattttcgaa 1449121 tgaagaagtt gtgttaaaac aggaccatct tgacagaacg cctgcacatt gtgtcatttt 1449181 ctcaggaatt tctaacgcct atttagaaaa cattgcagct caggcaaaaa gaaaacttgt 1449241 taagctgttt gagcgggatg acattgcgat atacaactct attccgacag tagaaggaac 1449301 gatcatgctg gctattcagc acacggatta tacgatacac ggatcacagg tggccgttct 1449361 cggtctgggg cgcaccggga tgacgattgc ccgtacattt gccgcgctcg gggcgaatgt 1449421 aaaagtgggg gcaagaagtt cagcgcatct ggcacgtatc actgaaatgg ggctcgttcc 1449481 ttttcatacc gatgagctga aagagcatgt aaaagatata gatatttgca ttaataccat 1449541 accgagtatg attttaaatc aaacggtact ttctagcatg acaccaaaaa ccttaatatt 1449601 ggatctggcc tcacgtcccg ggggaacgga ttttaaatat gccgagaaac aagggattaa 1449661 agcacttctt gctcccgggc ttccagggat tgtcgctcct aaaacagctg ggcaaatcct 1449721 tgcaaacgtc ttgagcaagc ttttggctga aatacaagct gaggagggga aataaggatg 1449781 tcgtcattaa aaggaaaaag aatcgggttt gggctgaccg ggtcgcattg cacatatgaa 1449841 gcggttttcc cgcaaattga ggagttggtc aacgaaggag ctgaagtccg tccggttgtc 1449901 acatttaatg taaaatctac aaatacccga tttggagagg gcgcagaatg ggttaaaaaa 1449961 attgaagacc tgactggata tgaggccatt gattcgattg taaaggcaga acctcttggg 1450021 ccgaagctgc cccttgactg catggtcatt gcgcctttaa caggcaattc aatgagcaag 1450081 ctggcaaatg ccatgacgga cagcccggtg ctgatggcgg caaaagcgac aatccggaac 1450141 aatcggcctg tcgttctggg tatctcgaca aatgatgctc ttggtttaaa cggaacaaat 1450201 ttaatgaggc tcatgtcaac aaaaaatatc ttttttattc cattcgggca agatgatcca 1450261 tttaaaaaac cgaattcaat ggtagccaaa atggatctgc ttccgcaaac gattgaaaag 1450321 gcactcatgc accagcagct tcagccgatt ctagttgaga attatcaggg aaatgactaa 1450381 atttacagaa aatctttccc aaactaaaaa attcggtcat cacccgcata ttctatggta 1450441 aaataaaacg taaaatcata gtcaaatcaa ttcaatgaag ctgattggcg gaaggagttt 1450501 tacagatggg aagaggttta cacgtagctg ttgtcggagc gacaggggct gtgggacaac 1450561 aaatgcttaa aacacttgaa gacagaaact ttgaaatgga cacacttaca ttgctatctt 1450621 caaaacgctc tgcggggaca aaagtcacgt ttaaaggcca agagctgact gttcaggaag 1450681 cttctcctga gagctttgaa ggggtaaata ttgctttgtt cagcgccggc ggaagcgtat 1450741 cacaagcatt ggcaccagaa gctgtaaaac gcggcgctat tgttatagat aatacgagtg 1450801 cgttccgcat ggatgaaaat acaccgcttg ttgtgccaga agtgaatgag gcagacttgc 1450861 atgaacacaa cggcattatt gccaatccaa actgctctac aatccaaatg gttgcggcac 1450921 ttgaaccgat ccgcaaagca tatggcttaa acaaggtcat cgtatcaact taccaggcag 1450981 tatcaggagc gggtaatgaa gctgtaaaag agctttacag ccaaacacag gcgattttaa 1451041 ataaagaaga aatagagcct gagatcatgc ctgtaaaagg tgacaaaaaa cactatcaaa 1451101 tcgccttcaa cgcgattccg caaatcgata aattccaaga taacggctat acgtttgagg 1451161 aaatgaaaat gataaatgaa acgaaaaaaa tcatgcacat gcctgacctt caagtagcgg 1451221 ctacatgtgt gagactgcca atccaaactg ggcactcaga gtccgtctac atcgaaatag 1451281 accgtgatga cgctacagtt gaagatatta aaaatctatt gaaagaagct ccgggcgtga 1451341 cacttcagga tgatccaagc cagcagcttt atccgatgcc tgctgatgct gtcggcaaaa 1451401 acgatgtgtt tgtaggccgc atccgcaaag acttggacag agcaaacggt tttcatttat 1451461 gggttgtttc tgataaccta ttaaaaggcg cggcatggaa ctctgttcaa attgcagaaa 1451521 gcctgaaaaa actaaacctc gtataaaaga gagaattttc taaagacgaa tagaagagag 1451581 taaggcgcta tcagcctgct ctcttctgtt acgtccgaat aatttggagt gaaaacagtg 1451641 aagataattg ttcaaaagtt cggcggaaca tcagtaaaag atgataaagg ccgcaaactg 1451701 gctttagggc atattaaaga agcaatcagt gaaggatata aggttgtcgt tgtcgtttca 1451761 gcgatgggcc gaaaagggga cccgtatgca acagattctt tgctcgggct gctttacggc 1451821 gatcagtcag cgatttctcc tagggagcag gatttgcttt tatcttgcgg agagactatt 1451881 tcctctgtcg tctttacaag catgctgctt gataacggtg tgaaagcagc tgcgctgaca 1451941 ggggctcagg ctggcttttt aacgaatgat cagcatacta atgcgaaaat cattgaaatg 1452001 aaaccggagc gtttattcag tgtgctcgcc aatcatgatg cggtagtcgt cgcaggcttc 1452061 cagggcgcaa ctgaaaaggg tgatacaaca acaatcggca gagggggcag cgatacgtct 1452121 gcagccgcac tcggagcagc tgttgatgcg gaatacatcg atattttcac cgatgtagaa 1452181 ggcgtgatga ctgctgaccc aagagtggta gaaaatgcaa aaccgcttcc tgttgtgacg 1452241 tatacggaaa tctgcaacct ggcgtatcag ggggccaagg tcatttctcc gcgtgctgtg 1452301 gaaatcgcaa tgcaggccaa ggttccgatc cgcgtccgtt cgacttattc gaatgataaa 1452361 ggcacattgg tgacatcaca tcactcttcc aaggtcggca gtgatgtttt tgaaaggctg 1452421 attacgggaa tcgcccatgt caaagatgtc acgcagttca aagtgcctgc gaaaatcggc 1452481 cagtataacg ttcagactga agtgttcaag gctatggcaa acgctggaat cagtgtcgat 1452541 ttctttaaca ttacacctag tgaaatcgtc tatacggtag ccggaaataa aacagaaaca 1452601 gctcagcgta ttttaatgga tatgggctat gatccaatgg tgacgagaaa ctgcgcgaag 1452661 gtatcggcgg tcggcgcggg cattatgggt gttcccggtg ttacgtccaa aattgtatcg 1452721 gctctttcag aaaaagaaat tccgatcctt cagtcggctg acagccatac gacgatatgg 1452781 gtgctcgtcc atgaagcgga tatggttcct gctgtaaacg ctttgcatga agtgtttgaa 1452841 ctttcgaagt aaatgtgatt gaatcatgat gaggtgaata aaatgaattt cggaaatgtg 1452901 tctacagcga tgattacacc ctttgacaat aaagggaacg tagactttca aaaactgtct 1452961 acactgattg attacttgtt gaaaaacgga acggattctt tagtagtagc gggaacaact 1453021 ggagaatctc cgaccctttc aactgaagaa aaaattgcgc tttttgaata tacggtaaaa 1453081 gaagtaaacg gacgggtgcc cgttatcgct ggtactggga gcaacaacac gaaagattcc 1453141 attaagctga caaaaaaagc tgaggaagcg ggcgtggacg ctgttatgct tgttaccccg 1453201 tattacaata aaccttctca agaaggaatg taccagcatt ttaaagcaat tgcggcagag 1453261 acatctcttc cggttatgct ctataatgtt cctggccgta cggttgcttc tcttgctcct 1453321 gaaacgacga tccgtttggc ggcagacatt ccgaatgtgg ttgcgattaa agaagcgagc 1453381 ggagacctcg aagcgattac aaaaattatt gctgaaacac ctgaagactt ctatgtctat 1453441 tcaggggatg atgctctaac gcttccaatt ctttcagttg gaggtagagg agttgtgtca 1453501 gtggcgagcc atattgcagg cactgatatg cagcaaatga tcaaaaatta tacgaatggg 1453561 caaacagcta atgcggcact gattcatcag aaactgctgc cgattatgaa ggaactgttt 1453621 aaagcgccta atcctgctcc agtcaaaaca gcgcttcagc tgagaggtct tgatgtcggt 1453681 tctgtgcgtc tgcctctagt cccattaact gaggatgaac gtctgagctt aagcagcacg 1453741 atcagcgaac tgtaagaaaa tttcatacag tgaaacaaac gcggtcattc tcacattcag 1453801 ctgagtttga ccgtttcttt tacatattgg ttttccctaa accttctgct ttatcttgtt 1453861 ttctaaattt actttcagtt ataataggaa caagtgatga tggacgggta tgagactagg 1453921 aggatataga ttttgaaaaa gaaaaataca gaaaacgtta gaattatcgc ccttggcggt 1453981 gtcggagaga ttgggaagaa cctttatgtc attgaaattg actcagacat atttgtcgtt 1454041 gatgccggcc ttatgcatcc agaaaacgaa atgctcggta ttgatgtagt gattcctgac 1454101 atatcatatt tgattgaacg ggctgaccgc gtcaaggcaa tctttttaac gcacgggcac 1454161 gatgaaaata tcggcggcgt tttttactta ttaaacaagc tgtccgttcc agtgtacgga 1454221 acaaaactga cgcttgcact gttaagagag aaattaaaac aatacggaca taaccgaaaa 1454281 actgatttaa gagaaattca ctccaaatct gtcattacat ttgaatcaac aaaggtatcg 1454341 ttctttagaa cgattcacag cattcctgat tctgtaggtg tgagctttaa aacatcactt 1454401 ggatctattg tatgcacggg agacttcaaa tttgaccaaa cacctgcact taatcagacg 1454461 tgcgacattg gcgagatcgc caagatcggc aatagcggcg tgctcgctct gctttctgac 1454521 agtgcaaatg cggaacggcc gggttacacc ccttcggaag cggctgtcag cggagaaatt 1454581 tcggatgcgc tgtataattc acagaaccgg gtgattattg ctgttttcgc atccaatatt 1454641 aaccggattc agcaagtcat tcatgcagcg gctcaaaatg gcagaaagat tgccgtagcc 1454701 ggaaaaaatc ttcaatctgt cctgcagctg gcgagaaagt taggatatat tgaagcagat 1454761 gatgaattgt ttatttctgt acaggatgtc aaaaaatatc cgaagcgcga agtggccatt 1454821 attacagccg gaagccaagg tgaaccatta gctgctttga caagaatggc aaacaaagct 1454881 cacaaacagc tgaacattga agaaggggat acggtggtca ttgcgtcaac tccgattccc 1454941 gggcaggaac tcatttactc taaaacagta gatcttcttg cgagagccgg tgcacaagtc 1455001 atctttgccc aaaagcgtgt tcatgtatca ggccacggct cacaagaaga gttaaagctg 1455061 atgatcaacc tgcttaaacc aaaatatttg attcctgtaa acggcgaata cagaatgcaa 1455121 aaagctcatt caaaaatcgc tgaagaaacc ggcatgaagc gcagtgacat cttcttaatt 1455181 gaaaaaggcg acgtcgttga attccgcggc caaaacgtaa aaattgggga taaagttcct 1455241 tacggcaata ttttaattga tggtttaggt gtcggtgata tcggcaatat cgtattgaga 1455301 gaccgccgct tgctttcaca ggacggaatt ttaatcgttg tcattacact tgataaacaa 1455361 aagaaacatc ttgtatcagg accagaaatt atcactcgcg gctttgttta tgtaagagag 1455421 tctgaaggtc ttatcgtaca ggctactgag cttgtacggt ccatcgtgac agaagcgact 1455481 gaaacatcaa atgtcgaatg gtcaacgctg aagcaggcaa tgcgggatgc tttgaaccaa 1455541 ttcctttatg aaaaaacgaa acgtaaaccg atgatcatcc caattattat ggaagtataa 1455601 tgactgacta aagaccggag ctgctccggt ctttattttt tgtccttcaa gccgggattg 1455661 aatgaagtat ctttgttcat aatacaaaga gaaactcgga aaggatgaaa gcgagatgga 1455721 tcatcgtatg gaaaacacag aagaagagcg tcctgaaaaa aatgatgcga aggacagcat 1455781 tatgaataaa atacagcagc ttggtgaaac gacgcttccg cagctgcccc aagatacaaa 1455841 tattcattgt ctgaccatta tcggacaaat tgaaggccat gttcagcttc ctccgcaaaa 1455901 caaaacaaca aaatatgaac atgtcatccc gcagattgtg gcaattgaac aaaatcccaa 1455961 aattgaaggc ttgctgatca tattaaatac tgtcggagga gatgttgaag ctggtcttgc 1456021 catagcggaa atgcttgcat ctttatcgaa accgaccgtt tctatcgtgc ttggcggggg 1456081 gcattcaatc ggcgttccga ttgctgtatc ctgtgattac agctatatcg ccgaaacagc 1456141 aacgatgacg attcatccag ttaggctcac cgggctggtc atcggggtgc cgcaaacgtt 1456201 tgaatacctg gataagatgc aagaaagagt tgttaaattt gtgacaagcc attccaatat 1456261 aaccgaagag aagtttaaag agctaatgtt ttcaaaagga aacttaacac gcgatatcgg 1456321 aacaaatgta gtcggtaagg atgcagttaa atacggattg atcgatcacg caggcggtgt 1456381 cggacaggca atcaataaac tgaatgagct catcgatgaa gcaaggaaag aagaaggacg 1456441 gatgattcaa tgattcttta taccgtgatg cctcaggaaa ttgtgtttgc agaacagaac 1456501 caagagacaa gcgcacatga gcaaattgaa tataaaggtg taccgcttct agtcgaaatg 1456561 aaagggaatg aagcggaagt cattcaaatc atgagcacca atccaatgca ttttctgcat 1456621 ccggacattt caccgggaca aaagctgaaa ttaaacgtat aagaatccaa ccctttttta 1456681 agggcaaaat atgctataat aggggaatcc tacagaaaaa acgcagcctg taaacggctg 1456741 ctttcttcat tatgtatgaa cttacatttt ttaacgcagt aaggtgatga gtgtggcaaa 1456801 gaaaaaacga aaatcaagaa aaaaacaggc gaaacagctc aatataaaat acgagctcaa 1456861 cggattgctg tgtatagcca tttcaattat cgcaatcttg cagctggggg tagtcgggca 1456921 aacgtttatc tatttgttcc gcttttttgc tggagagtgg tttattttat gcttgttagg 1456981 tttattggtg ttaggagtct cactgttttg gaagaaaaaa accccaagcc ttttaacgag 1457041 acgaaaggcc gggttgtact gtattatcgc aagcatattg ctgctttctc acgtgcagct 1457101 atttaaaaat ttgacgcaca aagggtctat tgagtctgca agcgtggtgc gcaatacgtg 1457161 ggaattgttt ttaatggaca tgaatggcag ctctgcttca cctgatttag gcggagggat 1457221 gatcggtgcg ctgctgtttg cggcttcaca ctttttgttt gcgtcgactg gttctcagat 1457281 catggcaatt gtcatgattt tgatcggaat gattttagta acaggacgct cgctgcaaga 1457341 aacgctaaaa aagtggatga gcccgattgg acgttttata aaagaacaat ggttagcatt 1457401 tattgatgac atgaaatcct tcaaatcaaa tatgcagtca tcgaaaaaaa cgaaagcgcc 1457461 gagcaaaaaa caaaaaccgg cccgcaaaaa acagcaaatg gaaccggagc ctcctgatga 1457521 agagggggat tatgaaacag tatcgcctct tattcattca gagccgatta tctcaagctt 1457581 ttctgatcgt aatgaagagg aagagtctcc agttatagaa aagcgcgccg aacctgtgtc 1457641 gaagccgctt caggacatcc aaccggagac aggtgatcag gaaactgttt ctgctcctcc 1457701 tatgaccttt acagagctcg aaaataagga ttacgagatg ccgtcactgg atttgctggc 1457761 agatccgaag cataccggcc agcaggctga taaaaagaat atttatgaaa atgcgagaaa 1457821 gcttgaacgc acattccaaa gctttggcgt aaaggcgaaa gtcacacagg ttcatctcgg 1457881 accggccgta acaaaatatg aagtatatcc tgatgtcgga gtgaaggtta gcaaaattgt 1457941 caatttaagc gatgatttag cgcttgcgct tgctgcgaag gatatcagga tcgaagcgcc 1458001 tataccaggc aaatcagcaa tcggaattga agttccaaac gcagaagtgg caatggtttc 1458061 gctgaaagaa gtgctggagt ctaaattgaa tgacagaccg gatgcgaagc tgttaattgg 1458121 actcggccgc aatatttcag gtgaagctgt attggctgag ttaaacaaga tgccccacct 1458181 tttggtcgca ggcgcaaccg gtagcgggaa aagtgtctgt gtcaacggca ttattacaag 1458241 tattttaatg cgggcgaaac cgcatgaagt gaaaatgatg atgatcgatc ctaaaatggt 1458301 agagctaaat gtctacaacg ggattccgca tttgcttgct cctgttgtaa ccgatccgaa 1458361 aaaagcgtcg caggctttga aaaaggttgt caatgaaatg gagcggcggt acgaattatt 1458421 ttctcatacg ggtacaagaa atattgaagg atacaatgat tatataaaac gcgccaacaa 1458481 tgaagaagga gcgaaacagc cagagctgcc ttatattgtt gtcattgtgg acgagctagc 1458541 cgatctcatg atggtcgctt catctgatgt ggaagattcg attacgagat tgtcccaaat 1458601 ggcgcgggct gccggcatcc atcttattat tgcgacacag cggccatcgg tggatgttat 1458661 cacaggggtg atcaaagcga acattccgtc acgaatcgcg ttcagcgtat cttcacagac 1458721 ggattcaagg accattcttg acatgggtgg cgctgagaag cttcttggcc gcggcgatat 1458781 gctgttttta cctgtagggg ctaacaaacc tgtccgtgtg cagggagcat ttttgtcgga 1458841 tgacgaagtg gagaaggtcg tcgaccatgt gattactcag cagaaagcgc aatatcaaga 1458901 agaaatgatt cctgaggaga cgacggaaac tcattccgag gttactgatg aactttatga 1458961 tgaagctgtt gaattaatcg tcggcatgca gacggcatct gtttcaatgc tgcaaagaag 1459021 attcagaatt ggctatacga gagcggcgcg cctgattgac gcaatggagg aacgcggtgt 1459081 tgtcggaccg tatgaaggca gcaaacctag ggaagtatta ttatcaaaag agaaatatga 1459141 tgagctctct tcttaatgaa gggagttccg ctttctatag ttgtcaataa tgatattatg 1459201 taaactgatc acctttctat ttattttttc gacaaaacat gatatagttg tcccaattgt 1459261 tcaataattt ttatcgaaag tggtttacgg aggggaaaca tgtctacaaa agctgataat 1459321 cggcacttgt atttgaaagt aattgaacga attaaagagg atataaaaaa tgggatctac 1459381 actgagaagg aaaagctgcc ttctgaattt gagctttcca aaaagcttgg tgtcagcaga 1459441 gcgacgctaa gagaagcctt gcggatactg gaagaagagc atgtgattat cagaaggcat 1459501 ggtgtaggca cttttgtcca ttctaagccg ttatttcttt cgggtattga acagctgaac 1459561 agtgtaacca agatgataga acaggcgaat atgacccctg gcacgatttt tctatcatca 1459621 caagtgctta tgccgtctga agatgatacg aagagatttc acttggcaga agggcaagaa 1459681 cttttttacc ttgaacgagt caggacagct gacggacagc cgattgtgta ttgtatagac 1459741 aaaattccga tgaatatttt gccgaattct ttttctcatc agcaagaatc tatgtttgac 1459801 ctgctagaga aaaattcagg ctccgtaatc agctatgcag taactgatat agaaccgatc 1459861 ggctatcacg ataccatttc tccagtgctt gaatgcgatc cggaaacagc tcttttgctg 1459921 ttaaaacaaa cccattacga tcagcacgat aaaccggtgc tttattcttt aaattatttt 1459981 agagcggata aattcagatt tcatgttttg cgtaaacgat tctaaaaacg gacgcctgta 1460041 tgtgtctgtt tttttatttg cactgattca tgtttctttg tacatacttt cattccggtt 1460101 aacgcaatat ataagggatg acaagaaagt gaatgggtga aaatgttgag agagaaaaat 1460161 ggaatgaaaa atattattgc attgtcttct gtcccgcttg tgatgacact cgggaactcc 1460221 atgctgattc ctgttcttcc gatgatggag aaaaagctgt ctgtgacttc atttcaagta 1460281 tctttaatca ttactgtata ttcagtagta gcaattattt gcattccgat tgccggatat 1460341 ttgtcggatc gtttcgggag aaaaaaaata ttgcttccat gcctcctcat tgcaggattg 1460401 gggggagccg tagctgcttt tgcctcgacc tatatgaaaa atccttatgc tatgatcttg 1460461 gcggggcggg ttcttcaagg cattggttct gcaggtgccg ctccgattgt catgccgttt 1460521 atcggcgacc tgtttaaagg agacgatgaa aaggtcagcg cgggtcttgg cgatattgaa 1460581 accgccaaca cgtcagggaa ggtactgagt cccatacttg gagccttact ggcttcttgg 1460641 tattggtttg taccgttttg gtttattccg tttttctgtt tgatcagctt tttgctcgta 1460701 ttgtttttgg tggccaagcc tgaagaagat gaagatgcgc ctgctgtttc tgagtttatt 1460761 aagagtgtga agaaaatttt taaacaggat ggtcgctggc tttatacggt cttcattatc 1460821 gggtgtgtca ttatgttttt gttatttggc gtattatttt atttatcaga tacgctggag 1460881 aacaagtatg ctattgacgg agtagctaaa ggcggattac tggcaatccc acttttgttt 1460941 ttgtcaacca gttcttttat agctggcaaa aagatcggta aagataaagg ccgaatgaaa 1461001 ttttgcgttg ttacaggaat gattctgtta accctttcgt ttattgcctt gtggtggaac 1461061 cacagttttt attttttatt tgtcttttta agctttggcg ggattgggat tggaatggct 1461121 cttcctgctt tagatgcatt gataaccgaa gggattgaaa gtgaacaatg cggaaccatt 1461181 tcctcctttt acaatagcat gcgctttata ggagtagctc tcggtccacc tgtttttgct 1461241 gcattaatgt ctaatgcaaa ctggattatt ttcatactct cggcgttttg cagcatcgtt 1461301 tctttatttt tagtgctctt tactgtagat gctaaaaaaa gtgaagaaga aaaaaactta 1461361 gggacggtct agccagccgt ctttttttgc gctttcttgc acagtttaca actgtaccta 1461421 tacagcatgc ggaggttatt gtttccttat aaatcctaca gttgctataa ttacatgaaa 1461481 gagtgtttct gcggatgctg aaaattggtc ataatacata ctaattaaga aatgaacgaa 1461541 ggaggttcca tatgtcatat gttaatgaac tcaaatcaaa gcacggcggt ttaaccgcac 1461601 acattgtaaa aacagaaaaa ttcaaaaccg tctcgcttat ttttaagatg cttgcgccgc 1461661 tgacaaagga tcaagtcacc aaaagagcgc ttctcccgca tgtgcttctt cgcggaacga 1461721 aaagccatcc gaaaaccgca ggattgcgtt catacttgga tgagctgtac ggcacgtcag 1461781 tatcggctga tcttacgaaa aaaggagagc ggcatgtcat tacgttcagg cttgaaatcc 1461841 cgaatgaaaa atatttaaaa gaccaaacgc cgcttctcga gaaagggctc cagcttctcg 1461901 cagaactcgt cttttcacct gctttggagg gagacgcttt tcagtcacaa tatgtggctc 1461961 aagaaaaacg gacgcttaag caaagaatcc aagccgtcta tgatgataaa atgcgttatt 1462021 cgaatttaag gctgatacag gaaatgtgca aaaatgatcc ttacgcgctt catgtcaatg 1462081 gtgaaatcga cgatgtcgat gacattacgg cagagcaatt atacgaaaca taccaaagcg 1462141 ctatccaaaa agaccagctt gatctatatg ttgttggcga cgtggacagt aaccaggtac 1462201 aatcggcaat tgataagtat ttcaaaacag aagagcgcac tcttggcatg attgaaaaca 1462261 atcacgctga tgaaaaagtt cagccaaaag aagtaattga tgaagaggat gtcaagcaag 1462321 gaaaactgaa tatcggctac cgcaccagca tcacttatac agatcaggat tatcctgctt 1462381 tacaagtgtt taacggattg ttcggcggat tctctcattc taaacttttc attaatgttc 1462441 gggaaaaagc cagtcttgct tactacgcgg cttcgcgtat agaaagtttt aaaggcttgt 1462501 taatggtgat gtcaggcatt gaagtgaaaa attttgaaca ggcggtttcg attattgctg 1462561 agcaattcca ggcaatgaaa aatggcgatt tcagtgagca ggatatagca cagacaaagg 1462621 ccgttattcg aaatcaagtg ctggaaacga ttgatacagc atacggttta tctgagtttt 1462681 tatatcagca ggccgctgct caagtcgaga ttcctatcga agactttctt gccaatattg 1462741 agaatgtcac aaaagaggat atcattaaag ccggcgaaaa gattcagctt gatacgactt 1462801 atttcttaaa agggacggag ggtgcatctt gatcaaacca atcgaatatg aacagcttca 1462861 ggagacgctg tatcatgaaa aaatgtccaa cggccttgat gtttacgttt tgccgaaaaa 1462921 aggcttcaac aagacatatg cggtctttac aacaaagtac ggctcgatag ataaccggtt 1462981 tgtcccttta ggtaaaaacg agatggttca cgtgccggac gggattgctc actttcttga 1463041 gcacaagctg tttgagaaag cggacggaga cgtttttcaa gatttcagca aacagggggc 1463101 ttctgccaat gcgtttacgt catttacaag aacggcttac cttttctcaa gcacatcaaa 1463161 tgttgaacgc aatttagaga cgcttatcga tttcgtacag gacccatatt ttactgaaaa 1463221 aacggttgaa aaggaaaaag ggattatcgg gcaggagatt aatatgtacg acgataaccc 1463281 tgattggagg ctttacttcg gggtcattga aaacatgtac aaagagcatc ctgtcagaat 1463341 tgacatagcg ggaacagtgg aaagcatttc acatattaca aaagaccttc tttatgaatg 1463401 ctatgaaacg ttttatcacc cgagtaacat gctccttttc attgtcggcc ctgtagatcc 1463461 tgaagcgatt atttctcagg taagagaaaa ccaggggaaa aagccgtata ctgatcagcc 1463521 ggagatcaaa cgagaagaag tgaaagagca agaagcggtt ttccgaaaag aaaaagagat 1463581 caaaatgaac gtgcagggac cgaaatgcct tgttgggctg aaatccaaaa atccgtttaa 1463641 attaggcaaa gagctcttaa agcatgaact ttcaatgaac ttattgcttg aagctctttt 1463701 tggcaaaagc tctgcccagt atgaatcact ttatgaaaaa ggatatattg acgaaacgtt 1463761 cagctttgat tttactgctg aatatgggtt cggttttgcg gcgatcggcg gagatacgcc 1463821 tgagcctgat caattggctg aagacatttc aagcatgctt ttgcgcgccg gtgaactgat 1463881 tactgctgaa aagattgaac ttgccagaaa gaaaaagatc ggcacattct taaaagcgct 1463941 gaattcccct gaatacatcg ccaatcaatt tacccgttat gcgttcttgg atatgagcct 1464001 gtttgatgtt gtaacggtac tcgagcagat taccctcgag gatgtccaga acgtaataca 1464061 agaggaaatc gctgcagaca gactgactgt ctgcaaggtt gttcctaaat cataaacaaa 1464121 acatccctcc agtgtgaggg gtgtttttct gcggaaagaa ggaaagagga tgaacaaaac 1464181 agcactaatc accggagcaa gcggcggcat tggcaaaagc atcagcgaaa cccttgcagc 1464241 tagaggatac aatctgctgc tgcattacaa tacaaatcaa aacgcggcag cggagcttgc 1464301 tgaaaaacta agtcagatgt ttggcgtaaa tgcggagata ttacaagctg acctgtccgc 1464361 gcaagatgga gcagataagc tgacaagttc aattgttcag ccgattgatg cgattgtttt 1464421 aaacagcgga cgaagccatt ttgggctgat tacggatgta gataacgcaa cggtccagga 1464481 aatggttcag cttcatgtgg cgagtccgta tatgctgacg agaaaccttc tgccaggcat 1464541 gattcggaat aaatcgggag cgattgtggc tgtcagctcg atttggggag agactggagc 1464601 atcctgtgaa gtgttgtaca gcatggcaaa aggagctcag cattcatttg taaaaggatt 1464661 ggctaaggag ctggcgccaa gcggaatcag agtaaacgcc gtagcgccgg gtgcagttga 1464721 tacaaatatg atgaatcaat ttaccccggc tgaaaaagaa gagatcgctg atgagattcc 1464781 gatcggccgg ctggcccggc cgcaagaaat tgcggatgca acagcttttc tcctgtctga 1464841 aaaagcgtca tatatcaccg gccaaattct gtcggtgaat ggcggctggc actgctgatc 1464901 cgaaaatatt cggtgtatag tttcttttgc gaaggacaca ataatcttgt aacttcacat 1464961 gaaatggagg aaacaagcat gtcagtatta gaaaactggg atagctggaa aaacttcctt 1465021 ggcgaccgtc tgaactatgc gcaagataaa ggtatgagcc aggatacgat tacagatctt 1465081 gcgacagaaa tcggcagcta cttggctaat gaagtggaat ctaagaacga gcaggaaaaa 1465141 gtgctggcag atctttggag tgtagcatca aaagatgaac agcacgccat tgccaatatg 1465201 atggttaagc ttgttgaaaa taacagcact cactaggaag agaggggatt tttcctctct 1465261 tttttatgtt ttcctcatca cagcaacatt cttctttcta attagagaaa aatgctttat 1465321 gataaaggaa ggtaaaattt tgccacaatg aagggggtat atcatttggc aaagctcgaa 1465381 tggtattttg aatatgaaat tcaagtgaac cgccccggac tgctcgggga tatttcatct 1465441 cttcttggga tgctttctat caacatcgta acgataaacg gcgtcgatct ttccagaagg 1465501 ggaatgctcc tcaggtgccg ccatatagat caaattaaac gattagaatc aatcttaaaa 1465561 acgatggaaa caattaaagt aacgaagctt agagaaccga ggcttcgcga ccgtcttgcc 1465621 gtacgccacg gccgttatat tcaacgggat gccgatgaca agaaaacgtt ccgctttgaa 1465681 cgggacgagc ttggcttatt agtcgatttt atggccgaat tgttcaaaaa agaaggccat 1465741 aaattaatcg gaatcagagg tatgccgcgt gtcgggaaaa cggaatcgat tgtagcctct 1465801 agtgtgtgcg agcaaaaggt ggctgtttgt gtcatcaacc ttgctgaagc agacgataag 1465861 aagccagctg attgccgatg aatacagcac tgaaaatgtc tttatcgttg acggaattgt 1465921 gtcaacacga agagggtcag aacgccatct ccagctggtc cgagaaatca tgcggctgcc 1465981 tgcaacaaaa gtggtggagc atccggacat attcgttcaa aatacagagt atacactaga 1466041 tgactttgat tatattattg aactgagaaa tgaccctgat gaggttatta catatgaaca 1466101 tgccgaggaa ccccaaatgt ttgatcaatc cgggttttca agctttgatt tttaaaattg 1466161 gaaggtgttt gttgtgactg aactaggaat ccggctcaaa gaagccagag aggaaaaagc 1466221 aatgtcattg gatgatctcc aagcggcaac aaagattcaa aaaaggtatt taaccgcctt 1466281 ggaggaagga aactatgaca ttattccggg gaagttttat gttcgggcat tcatcaagca 1466341 atatgcagaa gccgttgggc ttgatgcgga tcagctgttt gaggagcata aaaaagatat 1466401 ccctaatacg tatcatgatg atgtgtctga aaagatctcc ggcatgaatc ttcaaaagga 1466461 aatgccaaag ccagcatcta aggcgctgga gctgctgcca acaatacttg ttattctcgg 1466521 cgtgattgtc gtgattgcca ttgtgtacgc gatcattcaa tttgccaatc acaaaaacag 1466581 tgatgatcac aatgcggcat cagaaaaagc aattacgcaa agtgagagca agtacgaaat 1466641 ccctaaagat tcaacgctga aagagaatca aaataacagc tctgaaaaag agacagacac 1466701 taaaaaagaa acgaaagaaa acgaagataa gaaaaaagaa aatgacagtg agaagctgga 1466761 gattaaagct gctggcactg aaggatcgtt aacgacttat gaagtgtccg gcgctgataa 1466821 aatcgagctg gaactgaagg catcagacag ctcctggatt agagtgcgcg atgaaaacag 1466881 cagctcttta aaagaaggaa cgctgaaaaa agacgaaacc tataaaaaag acataactga 1466941 tcagaaacaa gttgatatcc gcaccggata tgcacctaat ctgaaaataa aaatcaacgg 1467001 taaggttctt tcatatgaac ttgatccgaa aaaagtgatg gcacaaacca taaagattgt 1467061 aaataaaaag gaagaaaagt catcttaatt accagatgac ttttcttcac gtccgagtat 1467121 gaaattggag gggctttatg tttaacttac caaataaaat cacactagct agaatcgcat 1467181 taatcccaat cttcatgatt atcatgctgg cgccgtttga ctggggcagg ctcgaagttg 1467241 gagacgaatc catcccggtc gcacatttgg cgggggccat tctatttatt attgcatcta 1467301 caacagactg ggtggacggg tattatgccc gaaaattaaa tctcgtaaca aacttcggga 1467361 aatttcttga tccgcttgcg gacaaactgc tcgtatccgc agcgttaatt atccttgttc 1467421 aatttgatct cgctccagct tggatggtca ttgtgattat cagcagggag tttgccgtga 1467481 caggtttaag gcttgtctta gccggaacag gagaagtcgt agctgctaac atgcttggta 1467541 aaatcaaaac ctgggcacag attattgcgg tatctgcatt gcttcttcat aatcttccat 1467601 ttgaacttgt gtcattcccg tttgcagact tggcgctgtg ggtagccgtc ttctttactg 1467661 tcgtctcagg ctgggaatat ttctctaaaa attgggaagc gttaaaaaca tctaactaag 1467721 aaagaaggac ttcgtcatgg aatttccaaa aaaagcagaa ataattgcag tcggttcaga 1467781 gttgctgctt ggtcaaatcg ccaatacaaa tgctcaattt atcagcaaac agctcgctga 1467841 aatcggggtc aacgtatttt atcatacagc ggtcggagat aacccggagc ggctgaagca 1467901 ggtcatccgc attgctgaag aacgctctga cttcattatt ttttcaggag ggcttggacc 1467961 cacaaaagat gatctgacga aagaaacgat tgcaaatacg ctgggacgtc cgcttgtgtt 1468021 aaatgatgag gcattccaat ccattgagga ctatttcaaa cgaacaaaac gcacgatgtc 1468081 acctaataac cgaaaacagg cgcttgtgat cgaaggctct gacgtgctgg cgaatcactt 1468141 tggaatggcc ccgggaatgc tcacagagca tgaatcgcgc tattatatgc ttcttcctgg 1468201 accgccgagc gaattgcgtc caatgtttga aaacgaggca aagcctcttc tgctgaaaaa 1468261 gatgggttca aatgaaaaaa ttgtgtcaac tgttcttcgc tttttcggta tcggtgaatc 1468321 tcagcttgaa gccgatttgg aagatattat tgatgcacaa accaatccga caattgcgcc 1468381 tttggcggct gatggagagg tgacgctgcg tctgacagcc aaacacgccg atgaaaagga 1468441 aacagagcgt ctgttaaaag aaacagaggc cgttatctta gagcgtgtcg gtgaattttt 1468501 ctatggttac gatgatactt ctcttgtaaa agagctatct atagcatgta aggaaaaagg 1468561 cataacaatt tctgcggcag aaagctttac cggagggctg ttttctgaat ggctgacgga 1468621 tcatagcggt gcctcaaaat tatttgccgg gggcgttgtt tgctatacaa acgacgtgaa 1468681 gcagaatgtg cttggtgtca agaaggaaac attagatcgt tttggggcgg tcagcaagga 1468741 gtgcgcatcc gaactggcta agggtgttca aaaactcact ggcagcgata tcggcattag 1468801 ctttactggt gtagcaggac ctgatgctca agaagggcat gagcctgggc atgtgtttat 1468861 cggcatttcc gcaaatggta aagaagaggt tcacgagttt cactttgcgg gctccagaac 1468921 ggggatcaga aaacgcggcg ctaaatacgg ctgccattta atcttaaagc ttttagagca 1468981 aaaataatat tttcagcaca ttatcctcct aagaaaacat gatttctctg atacattatg 1469041 atattttgat aggaatcacg ccaagaaaaa atccgaatat gcgttcgctt ttttcttggc 1469101 aaatcccttc aaacagggta tagtatatgt agtggtaaca taaaggagga aaaaatagaa 1469161 tgagtgatcg tcaggcagcc ttagatatgg ctcttaaaca aatagaaaaa cagttcggca 1469221 aaggttccat tatgaaactg ggagaaaaga cagatacaag aatttctact gtaccaagcg 1469281 gctccctcgc tcttgataca gcactgggaa ttggcggata tcctcgcgga cggattattg 1469341 aagtatacgg tcctgaaagc tcaggtaaaa caactgtggc gcttcatgcg attgctgaag 1469401 ttcagcagca gggcggacaa gccgcgttta tcgatgcgga gcatgcgtta gatccggtat 1469461 acgcgcaaaa gctcggtgtt aacatcgaag agcttttact gtctcagcct gacacaggcg 1469521 agcaggcgct tgaaattgcg gaagcattgg ttcgaagcgg ggcagttgac attgtcgttg 1469581 tcgactctgt agccgctctc gttccgaaag cggaaattga aggcgacatg ggagattcgc 1469641 atgtcggttt acaagcacgc ttaatgtctc aagcgcttcg taagctttca ggggccatta 1469701 acaaatcgaa gacaatcgcg attttcatta accaaattcg tgaaaaagtc ggtgttatgt 1469761 tcgggaaccc ggaaacaaca cctggcggcc gtgcgttgaa attctattct tccgtgcgtc 1469821 ttgaagtgcg ccgtgctgaa cagctgaaac aaggcaacga cgtaatgggg aacaaaacga 1469881 aaatcaaagt cgtgaaaaac aaggtggctc cgccgttccg tacagccgag gttgacatta 1469941 tgtacggaga aggcatttca aaagaaggcg aaatcattga tctaggaact gaacttgata 1470001 tcgtgcaaaa aagcggttca tggtactctt atgaagaaga gcgtcttggc caaggccgtg 1470061 aaaatgcaaa acaattcctg aaagaaaata aagatatcat gctgatgatc caggagcaaa 1470121 ttcgcgaaca ttacggcttg gataataacg gagtagtgca gcagcaagct gaagagacac 1470181 aagaagaact cgaatttgaa gaataaaaat aaaataagtt tcaaatgata caaaaggctg 1470241 agtgaaaaac tcagcttttt tgtattttgc aaaaaaatga taaaaatatt gctttttttg 1470301 acaacttttt tagggcttta ttcgtctaac aaaacgtgtg caaaatggaa tttattttgg 1470361 gaggaaaaaa tgaatgacaa gcccaacccg cagaagaact gcgaaacgca gacggagaaa 1470421 actaaataaa agaggaaaac tgttgtttgg tcttttagca gtgatggttt gcattacgat 1470481 ttggaatgct cttcatcgaa atagtgaaga aaacgaacca tctcaagaaa ctgcagcggt 1470541 ttcaaatacc gatcagaaaa aagaggtcaa aaagaaaact gccaaaaaat cagaggaaca 1470601 aatcaaaaca gtggatcgaa accaaaaaat cagcaattat ttaaaagaga tcggtttcag 1470661 cggaacagcc atgattgtca gaaatggaga aatcgtaaca aataaaggtt ttggctatgc 1470721 tgaccgtaaa cactacattc aaaataatcc attgacatct ttttatgtcg gttcatcaca 1470781 aaaagcgctg attgcaactg ctattttgca gcttgaggaa aaggggaaac ttcagacaag 1470841 tgatccggta agcacgtatt tacctcattt tcccaacgga caaacgatta ctttgaagaa 1470901 tctgcttaca catacatcgg ggataaacgg acatattgaa ggaaacggcg ccattactcc 1470961 ggacgattta ataaaagata tagaacttca gggaatcaaa cgtcagccgg gcgtatggga 1471021 ctacaaggat tccaactatt ctgttcttgc ttatattatt gctgaagtaa gcggtgagcc 1471081 ctatgaacag tacataaaga atcatatttt taaacctgcg ggaatgacgc atgcaggctt 1471141 ttacaaaaca tatgaaaaag aaccttatcc tgccgtcggg tataagatgg agggcagcaa 1471201 aacagttaca ccgtatatac ctgatttatc ccagctgtat ggagcgggtg atatttatat 1471261 gagcgctata gatatgtaca aatttgacca agcgctgata gacggaaaac tgtattcgca 1471321 aaaaagctat gaaaagatgt ttacgccagg gagcagctcc acatacggca tgggatttta 1471381 tgttgctccc ggaagctatt caaaccatgg tgttatgccg ggcttcaata tcttgaacag 1471441 ctttagcaaa tctgggcaaa ccattgttat tttgttctca aacattcaaa ataatgctaa 1471501 attgggccaa gtgaacaata aaatatacca gcttctaaat caagaatgat tggcgatctt 1471561 cttttggatg aattgcattc ggcacgtgaa aagaagactg gcctgcaaac gttaagatgg 1471621 caagcttgac aagtatttcc gacacattta caatgaagtt gtaacatttg tttttttaac 1471681 atgattgtta aaccatttaa acttgacaag ggcgatgaac acactcattc cctgtgaagg 1471741 ttctgtatgt tgagaaaact agacaatgta catgccgaca ctttttaagc aacaaccaag 1471801 ttcatagcaa gaggaggtga aagtatgacc ccaattatga tggttctcat ctccattttg 1471861 ctgattctac tcggtttagt tgttggctac tttgttcgta aaaccattgc cgaagcgaaa 1471921 attgcgggcg cacgcggtgc agccgagcaa attcttgaag atgcgaagcg tgatgctgaa 1471981 gcactgaaaa aagaagctct gcttgaagca aaggatgaaa tccacaaact tcgaatagat 1472041 gctgaacagg aagttcgtga aagacgaaat gagcttcaaa aacaagaaaa ccgtttactc 1472101 caaaaggagg aaaaccttga tcgcaaacat gagggaattg ataaacggga agcgatgttg 1472161 gagaagaaag atcattctct gaatgaacga caacaacata ttgaagagat ggaaagcaaa 1472221 gtggatgaga tgattcgtat gcagcagtct gagttggaac gaatttcgag tctgactcgt 1472281 gacgaagcga aacaaatcat tcttgagcgg gttgaaaacg agctttcaca tgacatcgcc 1472341 atcatgacaa aagaaactga aaaccgtgcg aaagaagagg cggataagaa agcgaaaaac 1472401 attctttcac tcgccttaca gcgctgcgca gcggaccacg ttgccgaaac aacggtatca 1472461 gttgtcaatc ttccaaatga tgagatgaaa ggacgtatca tcggacggga agggcgtaac 1472521 attcgtacgc ttgaaacgct gacaggaatt gacctgatta ttgatgatac gcctgaagct 1472581 gtcattcttt ccggatttga tccgatcaga cgtgagacag ccagaattgc tcttgataaa 1472641 ctcgttcagg atggccgtat tcatccggca cggattgaag aaatggttga aaaatctcgc 1472701 cgcgaggtcg atgactatat tcgtgagatg ggtgagcaaa cgacatttga ggttggcgtt 1472761 catggcctcc acccagatct catcaagatc ctcggccgct taaagttccg tacaagctac 1472821 ggtcaaaatg tgcttaagca ttccatggaa gtcgcattct tggccggtct aatggcatcg 1472881 gagcttggtg aagacgcaaa gcttgctaaa cgtgcgggtc ttcttcacga catcgggaaa 1472941 gcaattgacc atgaagtaga aggaagccac gttgagatcg gggtagagct tgcgaccaaa 1473001 tataaagagc acccagtcgt gattaacagt attgcatcac accacgggga cgaggagccg 1473061 acttccatta ttgctgtact ggtagctgca gcagatgcgc tttccgctgc aagacctggc 1473121 gcaagaagtg agacgctcga gaattatatt cgaagacttg aaaaacttga agaaatttct 1473181 gagtcctacg aaggtgttga aaaatcattt gccattcagg ctggacgcga agtgcgaatt 1473241 atggtgaagc cggattcaat taatgatctt gaggctcatc gactggcgcg agatatccgc 1473301 aagcgaattg aggacgagct cgattatcca ggtcatatta aggtgacagt aatcagagag 1473361 actcgagccg tagagtatgc aaaataaagt gatgcgctaa gcatcacttt atttttttga 1473421 cggcaaggaa ttttcaagaa gaaaggattt acaaaatgag aattttattt atcggagatg 1473481 ttgtcggttc accgggccgt gacatggtca aagaatatgt accaaagcta aaaacaaaat 1473541 ataagcctca ctttaccatt attaatggtg aaaacgccgc acatggaaaa ggcctgacgg 1473601 aaaaaattta tcacagctta atccagtccg gcgcagatgc aatcacaatg gggaaccaca 1473661 catgggacaa aaaagaaata tttgatttta tagatgacgt tccgaacttg gttcgcccgg 1473721 caaactttcc tgaaggaaca ccggggaaag ggatcacata tgtgaaagca aacggcaaag 1473781 aactagcagt cattaatttg cagggacgta cgtttttgcc gccgcttgat gacccgtttt 1473841 taaaagcgga tgaattgatc gcagaagctg cgaaaagaac accgtacatt tttattgact 1473901 ttcatgccga agcgacaagt gaaaagctcg cacttggctg gtacacggat ggacgggcat 1473961 cggctgtagt aggaactcat acacacgtgc aaacagcgga taaccgcatt ttgccgaagg 1474021 gaacggcata tattactgat gtgggaatga ctggcccgta tgacggtata ctggggatgg 1474081 acagagagac gattattaag cgattcaaaa cgaaccttcc agtccggttt actgtcgctg 1474141 aaggaaaaac aacgctcagc ggagttgtca ttgacattga cgatcaaacg aaaaaagccg 1474201 tgaaaattga gcgtatttta atcaacgatg atcacatgtt ctttgaatag ttgaacatat 1474261 ggttatttta taaaaatatt aaaaagaaaa gcaggaatat agcaactcct tagtgaatat 1474321 agtaaaaatg gaaggtagcc cgctattttt gaaaagcatt gtggggatgg ctttttggat 1474381 agcaacatct aataatgatt gttctaatga acactcactt atccattgta aaactaaggg 1474441 ggagcagaaa tggaaatctt aaaagtttca gcaaaatcga gtccaaattc agtggcaggt 1474501 gcgcttgcag gcgtgttgag agagcgagga gccgccgaga ttcaagcgat cggagcgggt 1474561 gcattaaacc aggctgtaaa agctgtggcg attgccaggg gatttgtggc gccaagcggc 1474621 gttgatttga tttgtattcc ggcttttaca gatattcaaa tcgatgggga agaaagaaca 1474681 gcgattaaat taatcgtgga gcctcgctaa aaacaaataa agcattctca acctgtttgc 1474741 gtaatgcaaa caggttgttt ttcatttatt gtgatatttt ctcccgatag tatttttagc 1474801 acataaatga gcgaatatac aaaatcagaa atgagctaaa acgtttcaaa aaaaatttcc 1474861 gcccattttt caagacagat acttttgtcc ttctggaaaa gacagttctg tttacgctta 1474921 ttccatatca tggtacaatc cgaatataac aagaattttt caaggaggat tgtacatgca 1474981 gagtggaaag atgaaagctc taatgaaaaa ggacggggcg ttcggtgctg tgctgactga 1475041 agttcccatt cctgagattg ataaacatga agtcctcata aaagtgaaag ccgcttccat 1475101 atgcggcacg gatgtccaca tttataattg ggatcaatgg gcacgtcaga gaatcaaaac 1475161 accctatgtt ttcggccatg agttcagcgg catcgtagag ggcgtgggag agaatgtcag 1475221 cagtgtaaaa gtgggagagt atgtgtctgc ggaaacacac attgtctgtg gtgaatgtgt 1475281 cccttgccta acaggaaaat ctcatgtgtg taccaatact gctataatcg gagtggacac 1475341 ggcaggctgt tttgcggagt atgtaaaagt tccagctgat aacatttgga gaaatcccgc 1475401 tgatatggac ccgtcgattg cttccattca agagccttta ggaaatgcag ttcataccgt 1475461 actcgagagc cagcctgcag gaggaacgac tgcagtcatt ggatgcggac cgattggtct 1475521 tatggctgtt gcggttgcaa aagcagcagg agcttctcag gtgatagcga ttgataagaa 1475581 tgaatacagg ctgaggcttg caaaacaaat gggagcgact tgtactgttt ctattgaaaa 1475641 agaagacccg ctcaaaattg taagcgcttt aacgagtgga gaaggagcag atcttgtttg 1475701 tgagatgtcg ggccatccct cagcgattgc ccaaggtctt gcgatggctg cgaatggcgg 1475761 aagatttcat attctcagct tgccggaaca tccggtgaca attgatttga cgaataaagt 1475821 ggtatttaaa gggcttacca tccaaggaat cacaggaaga aaaatgtttt caacatggcg 1475881 ccaggtgtct cagttgatca gttcaaacat gatcgatctt gcacctgtta ttacccatca 1475941 gtttccatta gaggagtttg aaaaaggttt cgaactgatg agaagcgggc agtgcggaaa 1476001 agtaatttta attccataaa gggggataaa catgacgaag gaatttgagt ttttaaaagc 1476061 agagcttaat agtatgaaag aaaaccatac atggcaagac ataaaacagc ttgaatctat 1476121 gcagggccca tctgtcacag tgaatcacca aaaagtcatt cagctatctt ctaataatta 1476181 cctcggattc acttcacatc ctagactcat caacgccgca caggaggccg ttcagcagta 1476241 tggagccggc accggatcag tgagaacgat tgcgggtaca tttacaatgc atcaagagct 1476301 tgagaaaaag ctggcagcct ttaaaaaaac ggaggcggca cttgtattcc aatcaggctt 1476361 cacaacaaac caaggcgtac tttcaagtat tctatcaaaa gaggacattg tcatctcaga 1476421 tgaattgaac catgcctcta ttattgacgg aattcgactg acaaaggcgg ataaaaaggt 1476481 gtatcagcac gtcaatatga gtgatttaga gcgggtgctg agaaagtcaa tgaattatcg 1476541 gatgcgtctg attgtgacag acggcgtatt ttccatggat ggcaacatag ctcctctgcc 1476601 tgatattgta gagctcgctg agaaatatga cgcatttgtg atggtggatg acgcccatgc 1476661 atccggagta cttggcgaaa acggcagggg aacggtgaat cacttcggtc ttgacggcag 1476721 agtgcatatt caggtcggaa cattaagcaa ggcaatcgga gtgctcggcg gctacgctgc 1476781 aggttcaaag gtgctgatcg attatttgcg ccataaaggc cgtccatttt tattcagcac 1476841 atctcatccg ccggcagtca ctgcagcttg tatggaagcg attgatgtct tgcttgaaga 1476901 gccggagcat atggagcgct tgtgggagaa tactgcctat tttaaagcaa tgcttgtgaa 1476961 aatgggtctg actctcacga agagtgaaac gccgattctt cctattttaa taggtgatga 1477021 aggtgtggca aagcaatttt cagatcagct cctttctcgc ggtgtttttg cccaaagtat 1477081 cgttttcccg actgtagcaa agggaaaagc cagaattcgc acgattataa cagcagagca 1477141 caccaaagat gaactggatc aggcgcttga tgtcatcgaa aagacggcaa aggagctcca 1477201 gctattgtaa caagaggaag agtttactct tcctcttttg attccttatt gattattatt 1477261 ctcaatgagt gtacaatgat aggttgccag ttgtgcagag cttcaataac ctttatactg 1477321 aagggtggaa gtttggtttg aaaggagaaa atatgacatg aatgaaaaac aaaaattaga 1477381 gagcggacaa gttcatccat cggacaaaaa atccgagaag gattacagca agtactttga 1477441 agctgtttac attccgcctt ctttaaaaga cgcgaaaaaa cgaggcaagg aagccgttac 1477501 ttatcataat gactttaaaa tttctgaaca atttaaagga ttgggagacg gaagaaagtt 1477561 ctatatccgt acgtacggct gccaaatgaa tgaacacgat acagaggtta tggcagggat 1477621 ctttatggcg ctcggttacg aagcgacaaa ctctgttgac gatgccaatg tcattttgtt 1477681 aaatacatgt gcaatccgtg aaaatgctga aaacaaggtg tttggtgagc tcgggcactt 1477741 aaaagcactg aaaaaaaaca atcccgatct gattttaggc gtgtgcggct gtatgtccca 1477801 agaggaatca gtcgtgaacc gtattttgaa aaaacatccg tttgtcgata tgattttcgg 1477861 aacgcataac attcatcgcc tgccggagct tttgtcagaa gcataccttt caaaagaaat 1477921 ggttgtagaa gtttggtcta aggaagggga cgttattgaa aaccttccaa aagtccgaaa 1477981 tggaaaaatt aagggctggg tcaatatcat gtacggctgt gacaaattct gtacgtattg 1478041 cattgtgcct tacacacgcg gaaaagaaag aagccgccgc cctgaggata tcattcagga 1478101 agtgagaagg ctcgcaagtg aaggctataa ggaaattact ctgttaggcc aaaacgtaaa 1478161 cgcgtatgga aaagactttg aagatatgac gtacggactt ggtgatttga tggatgaact 1478221 gagaaaaatc gatatcccga gaatccgttt tacaacgagt catccgcgcg actttgacga 1478281 ccgcctcatt gaagtgctgg caaaaggcgg aaatctgctt gatcacattc atcttccggt 1478341 tcaatcagga agctcagaag ttctcaagct gatggcccgc aaatatgaca gagagcgtta 1478401 catggagctg gtgcgaaaaa ttaaagaagc aatgccaaac gcttctttga caacggacat 1478461 tatcgtcgga tttccaaatg aaacggacga acagtttgaa gaaacgcttt ctctataccg 1478521 tgaagtggag tttgacagcg cctatacgtt catttactct ccgcgtgaag gcactccggc 1478581 tgctaagatg aaagataatg taccgatgcg tgtgaaaaaa gaacgcctgc agcgtctaaa 1478641 cgcactggtg aatgaaattt ctgctaaaaa aatgaaggaa tacgaaggca aggttgtcga 1478701 agtattagtt gagggtgaaa gcaaaaataa ccctgatatt cttgctggct atactgaaaa 1478761 aagcaagctt gtcaatttca aagggccgaa ggaagccatc ggcaaaatcg tccgcgtgaa 1478821 aatccagcaa gcgaaaacat ggtcgcttga cggagaaatg gtaggagaag caatcgaggt 1478881 gaaatgagat gacgctctac tcaaaaaaag acattgtgca gcaggctcga aaccttgcaa 1478941 aaatgatttc tgaaacagaa gaggttgatt ttttcaaacg ggctgaagcg caaatcaatg 1479001 agaatgacaa agtgtccaca atcgttaatc agattaaagc cctgcaaaag caggctgtca 1479061 atctgaagca ttatgaaaag catgaagcgc tcaaacaagt agaagcaaaa attgacgcgc 1479121 tgcaagaaga gcttgaagag attcctgtta tccaggaatt cagagactcg caaatggaag 1479181 taaatgacct actgcagctc gttgcacaca ccatttccaa ccaagtcaca aatgaaatca 1479241 tcacatcaac cggaggcgac ctgctgaaag gggaaaccgg ttcaaaggtg aagcattcaa 1479301 ataacagctg ttctctctaa acacggtgcc tttacaggcc cgtgtttttt tatcatttgt 1479361 gcggttaaaa atgaactaaa taatctatgt accaaatgtt caattggttt ttctgtgctc 1479421 agccgcgtat aaactttatc gcacttataa gtaaagtttc taggcacccc tgcatacaat 1479481 ggaacagaaa ctttgtattt ttatatttta tttataaaaa tgcacactag acaaatgccc 1479541 agcataagat aacacgaaga agaacaagga ggcatgccgg aatgtctgaa tacagggaaa 1479601 ttattacgaa ggcagtagta gcgaaaggcc gaaaattcac ccaatgcacc aacaccatct 1479661 cgcctgagaa aaaaccgagc agcattttgg gtggttggat tattaaccac aagtatgacg 1479721 ctgaaaaaat tggaaaaacg gtagaaattg aagggtatta tgatataaac gtatggtact 1479781 cttacgcgga caacacaaag acagaggttg tcacagaacg ggtaaaatat gtagatgtca 1479841 ttaaactcag atacagagac aataattact tagatgatga gcatgaagtg attgccaaag 1479901 tgcttcagca gccaaactgc cttgaagtga ccatttcgcc gaatggaaat aaaatcgttg 1479961 tgcaggcaga aagagaattt ttggcggaag tggtagggga aacaaaggta gttgttgagg 1480021 tcaatcctga ctgggaagag gatgacgagg aagattggga agatgagctt gatgaagagc 1480081 ttgaagacat caacccggag tttttagtgg gagatcctga agaataaaaa agggactagg 1480141 ggagacagta cccccaagtc tcttttttat attgatatat cattctttta tcactttttg 1480201 tttatgttat aatgaaggtt ggaaaataga aacgttgata catagtgagg gattaaacaa 1480261 tggccggtta tacgcctatg atacagcaat atttaaaaat aaaggcagag caccaggatg 1480321 cctttttatt ttttcgcctg ggtgattttt atgaaatgtt ttttgaggac gccaaaaaag 1480381 cgtcacaaga gctggaaatt acgttaacga gcagagacgg cggtgcggct gaaaaaatac 1480441 cgatgtgcgg tgtgccgtat cattctgctt ccgcgtatat cgaacagctt attaaaaaag 1480501 gatacaaagt ggcgatctgt gaacagacgg aagatccgaa agccgcaaag ggcgttgtga 1480561 aaagagaagt agttcagctg attacgcccg gaactgtaat ggacggcaaa ggcatccatg 1480621 agtcggaaaa taattttatc gcatctgttt cagcctgctc gaacggatac ggacttgctc 1480681 tgtctgattt aacaacggga gaaaatttgg ctgttttgat tgaacggctt gaagacgtca 1480741 tatcagaaat ttattcagtc ggcgcacggg aaatcgtggt ttcaggaagc ttggatgccg 1480801 atacagtggc acagctgaga gagcggtgcg gtgcaacgat ttcaattgaa gacggagaaa 1480861 cagacgaaca cgtaacgatc attgagcact taaataatga agatataaca aaaacatttc 1480921 tgcgcttata tacgtatttg aaaagaaccc aaaagcgcag ccttgatcat cttcagcccg 1480981 tgcaggtgta tgagcttgag gaagcgatga aaattgactt gtactcaaag cgtaatctgg 1481041 agctgaccga aacgattcgt tcgaaaaata aaaaaggctc ccttttgtgg ctgctggatg 1481101 aaacaaaaac ggcaatggga ggccggctac ttaaacagtg gattgaccgg ccgcttatca 1481161 gagtcaatca aatcgaagag cgccaagaaa tggtggaaac attaatgtcc catttctttg 1481221 aacgggaaga tctgcgtgaa cgtttaaaag aagtatatga cttagaacgc cttgccggcc 1481281 gcgttgcatt cggaaatgtc aatgcccggg atttgattca gctgaaggaa tcgttaaagc 1481341 aagtgcctgg catcaaacag ctggttgctt cactggctca tgacaaggcc aaggaacgtg 1481401 caaagcgcat tgacccttgc ggggatgtac ttgaactgct ggaagaagcg ctgtacgaaa 1481461 accctccttt atcggtaaaa gaagggaacc tgattaaaga tggttataat caaaagcttg 1481521 atgaatatcg tgatgcaagc agaaacggaa aagactggat tgcccgcctg gaacagcagg 1481581 agcgggaata cacaggcatt cgctctttaa aggtcggctt taataaagtt ttcggttatt 1481641 acattgaagt gacaaaagca aacttgcatt tgcttgagga agggcgttat gagcggaagc 1481701 agacgttaac caatgcagag cgctacatta cacctgaatt aaaagaaaaa gaagcgctca 1481761 ttttagaggc ggaaaataac atctgtgagc tggagtacga gctgtttacc gagctgcgcg 1481821 agaaagtgaa gcagtatatt ccgcggctgc agcagcttgc aaaacagatg agcgagctgg 1481881 acgcactgca atgctttgcg acaatcagtg aaaatcgcca ctacacgaaa ccagagttct 1481941 ctaaagatga agtcgaagtg attgaaggca gacacccggt tgttgaaaaa gtcatggaca 1482001 gccaggaata tgtcccgaac aactgtatga tgggcgataa cagacaaatg cttctcatta 1482061 caggtccaaa catgtcaggg aaaagcacgt atatgagaca aatcgcgctc atttccatta 1482121 tggcgcaaat cggctgcttt gtacccgcga aaaaagcggt gctcccgatt ttcgatcaaa 1482181 tttttacgcg aatcggcgct gcagatgatt tgatttccgg acaaagtaca tttatggtag 1482241 aaatgcttga agcgaaaaat gcgattgtca atgcgacgaa aaacagcctc attctgtttg 1482301 atgaaatcgg gcggggaacg tccacttatg acggcatggc gctggcacag gcgattattg 1482361 aatatgttca cgatcatatc ggcgccaaga cgctgttcag cacacactat cacgagctga 1482421 ccgttcttga ggacaagctg ccccagctga aaaacgttca tgttcgcgct gaagaatata 1482481 acggaacggt tgtctttctt catcaaatta aagaaggtgc ggctgataaa agctatggta 1482541 tccatgtagc tcagcttgcc gaactgccgg gagatctgat tgcgcgcgct caagatattt 1482601 taaaagagct tgagcattca ggaaacaaac cggaagtgcc ggtgcagaaa cctcaggtga 1482661 aagaagagcc ggcacagctg tccttttttg acgaagcgga aaagccggct gaaacaccaa 1482721 agctttcaaa aaaagaaaag caagtgatcg atgctttcaa atcacttaat atactggata 1482781 tgacaccgct tgaagcgatg aatgaaatgt acaagctgca aaagaaatta cattaaaacg 1482841 gggtgatgaa tgtggcaaaa gtcatccaac tgtcagatga gctttcaaat aaaatagcgg 1482901 cgggcgaggt tgtggaacgg cccgcctcag tcgtcaaaga attggtggaa aatgcgatcg 1482961 acgctgacag cacagtcatt gaaatcgata ttgaggaagc aggccttgca tccattcggg 1483021 tcttggataa cggcgaagga atggagaatg aagattgcaa gcgagctttc cggcgccacg 1483081 caacgagtaa aataaaagat gaaaatgatt tattcagggt gagaacgctc ggtttcaggg 1483141 gagaagccct gccgagtatc gcgtcagtct ctcatctgga gattacaaca agcactggtg 1483201 aaggagctgg gacgaagctc gtcctccaag gaggaaacat catttccgaa tcgcgttcct 1483261 caagcaggaa gggaactgaa attgtcgttt ccaacctgtt ttttaacaca ccggcccgtt 1483321 tgaaatatat gaaaaccgtt catacagagc ttggaaacat tacagatgtg gttaaccgta 1483381 ttgctctggc gcatccagag gtatcgatcc gcctgcgcca tcatgggaaa aacctgcttc 1483441 aaacgaacgg aaacggagat gtgcgccatg tactggcagc gatttacggc acggctgtcg 1483501 ccaaaaaaat gcttccgctg catgtgagct ccttggattt tgaagtaaag ggatatatcg 1483561 ccctcccaga gattacacgg gcgtcgagaa actatatgtc gtctgtggtc aatggccgtt 1483621 acattaaaaa tttcccgctc gtcaaagcgg ttcatgaagg ctatcatacg cttctgccga 1483681 tcggacgcca tccgattact tttatagaaa ttacgatgga cccgatttta gtcgatgtca 1483741 acgtgcatcc atcgaagctt gaggtccggc tcagcaagga aacagagctt catgacttaa 1483801 tacgtgacgg aattaaagat gtgtttaaac agcagcagct gattcctagt gcccaggtcc 1483861 cgaaaaaatc agcacctgcc atcaaaaatg agcagcagtt tataaccttt gatgaaaagc 1483921 ctccggaaaa aaaagttccg gaaaaatcga ctgcgccatc ttattcaccg atgaagctca 1483981 gctcagtcgt aaaagagccg gttgatgcgg aggaaaaatt gccccctctc caatttgatg 1484041 ctcctcctat cgttgatcag gaacaaaccc ttgaggtgtc cgatgtttca gcagaacagc 1484101 ctgaaacatt tgagcaggaa tgccatgagg aacagccgca gccagcgtct gatcgggttc 1484161 caattatgta cccgattggc cagatgcacg ggacttatat attggcacaa aacgaaaacg 1484221 gcctatatat tatcgaccag cacgccgccc aagaacgtat taaatatgag tacttccgtg 1484281 aaaaggtggg ggaggttgag cctgaggtgc aggagatgat tgtaccgctg acgttccact 1484341 actccacaaa tgaggctttg attattgaac agcacaaaca agagctcgaa agcgtcggtg 1484401 tctttttaga gtcattcggc tctaacagtt acatcgtccg ctgccaccca gcctggtttc 1484461 caaagggaga agaagcagag cttatagaag aaatcattca gcaggtgctc gactccaaaa 1484521 atatagatat taaaaaactt cgcgaggaag cggcgattat gatgagctgc aaaggctcca 1484581 tcaaagcaaa tcgccacctc agaaacgacg aaatcaaagc gcttctggac gacctccgaa 1484641 gcacatcaga cccatttaca tgcccgcacg gccgcccgat catcattcac cactcgacat 1484701 atgagatgga aaagatgttc aaacgcgtga tgtagcgggg gtggtaggca ttgatccatt 1484761 ctctgaatgg gaattcacgg ggcatacgga taataggggt atccgccata caaataagga 1484821 ttaaataaag cgcttcctat aagcccgcct gcaaggccgc cgataaacgg tcctccaaaa 1484881 aatccgaatg gccggccaaa cccataacca aatccgggtc ttccaaaccc gtaaccgaac 1484941 ccgaacggtc ttccaaaccc aaatggtctc ccgaatccga acggccttcc aaatattctt 1485001 gtatcttcag ggctgaaatg ctctaactcg ttcatgtttt ctttcctcct gtaataaagt 1485061 gtagatgatg cagtgtattc accctgcccg gatttgattg ggcgaatcga ggaaaaggag 1485121 gatgtgaaca cattgggcct gtatcagtct gactggtcaa aagcaccgcc ccacgcacat 1485181 gcttatcatg tcaaaacaac gagagaacag ggccattatc atctcatcga agggtttact 1485241 cagccggcaa acggatcaaa taccgatcag catacacatt actatacagg gatcacttca 1485301 tttgaaaacg gccattttca tcggtattac ggaatctcag gaccggcgat tcccttagca 1485361 gatggcacac attatcatga aatcgaagaa acgacgtatc tggcctataa cgagccgatt 1485421 gagatccagt acggaggggt tgtgtacgat cccggagatg acagaagaaa aacgcatcgt 1485481 cataccctga aaggaaagac aagggaaatt gtcggcaatg agccgctcgg ctggtagaag 1485541 gatgtttacc gatgcaaaaa aagggcaaaa tggataggtg gttgtccatg ttgaatgcta 1485601 taatgggggg agatttataa aagagagtga tacatattga ataatacgaa gcagcccgtt 1485661 gtcattttag tcggaccgac ggcagtgggg aaaaccaatt taagtattca gctagccaaa 1485721 tccttaaacg cggaaattat cagcggagat tcgatgcaga tttataaagg gatggatatt 1485781 ggaacagcta aaattaccga acaggagatg gagggagtgc cccatcatct gattgacatt 1485841 ttagatcccc aagactcttt ctctactgcc gattatcaaa gcttagtaag aaataaaatc 1485901 agcgagattg caaatagagg aaagcttccg atgattgtcg gcggtacagg gctttatata 1485961 caatctgtgc tttacgatta tacatttacg gaagaggcaa atgatcccgt gtttcgagag 1486021 agcatgcaaa tggctgctga gcgggaaggc gctgactttc ttcatgccaa acttgctgca 1486081 gcagatcccg aggcagcagc tgcgattcat ccgaataata caagaagagt cattcgcgca 1486141 ctggaaattt tacatacgtc cggaaaaacg atgtcccagc atttgaagga acaaaaacga 1486201 gaacttctgt acaatgcagt gttaattggc ctgacaatgg atagagacac gctttacgaa 1486261 agaattaatc agcgggtcga tttgatgatg cagtcaggcc ttcttccgga agtgaaacgc 1486321 ttatacgaca agaacgtgag agactgtcaa tcaatacagg cgataggcta taaagagctg 1486381 tatgcatatt ttgacggttt tgtgacactt tccgatgctg tcgaacagct aaagcagaac 1486441 tcgaggcggt atgcgaaacg ccagctgacg tggtttcgca acaaaatgca ggtcacatgg 1486501 ttcgatatga caccgcctgt tgatatggag ctgaaaaaaa aggaaatttt cacacatata 1486561 gcaggaaaac tcgaacttta atcgaaactg tatgatatag agaatcaagg aggacgaaac 1486621 atgaaaccga ttaatattca ggatcagttt ttgaatcaaa tccggaaaga aaatacgtat 1486681 gtcactgttt ttttgctgaa cggctttcag ttgcggggcc aggtgaaagg ctttgataac 1486741 tttaccgtat tgttggaatc ggaaggtaag cagcagctta tatataaaca tgcgatctca 1486801 acgtttgcgc cgcaaaaaaa cgtccagctt gaactcgaat agatcaaaaa atgccatgtc 1486861 aagacatgag gaaaggctgt cgggggttcc cggcggccat ttttaacatg aatccacttt 1486921 tgctccaagc tttttgtgta agctgaccat gccaaggcac ggtctttttt tatgagaaca 1486981 acatacggaa gtaaaaatgg tatattatgt ataaaatgaa tttgggagtg atcgatcttg 1487041 tttgaaagtg aagcagaact gagacgaatc aggattgcac ttgtatggat agctgtcttt 1487101 ttactgttcg gggcgtgcgg gaatcaagat accattattg aaacagacaa cggcaattca 1487161 gactatgaaa cgcctcagcc cacctcgttt ccacttgaac ataaccattt tggcgttatg 1487221 gaggacggct atatcaaaat ttatgagtat aatgagtccc gcaatgaggt aaagctgaag 1487281 aaagaatacg cggatgatga gcttgaataa aattcacaag cattcgaatt tacaaagcgg 1487341 atgccagccg ctaaactaaa tacagacaca gatcaaacag agggtgaaaa catgaagcat 1487401 aaagtgatcg tgaatcattg ggaagaaatt tgcgaagatg attcttgcta tgaatacgga 1487461 acaagtatca ttgtgaacgg aaaagaatta atcagagaag cgtcaattat cactgctttg 1487521 aaggcggttt tagaagagat cggcgcggat gttgaaatag aagaaacagt agagagcgaa 1487581 aaatgctgtg atagcttaag aaaaaaaaat ctagactact aagcagtttt ttttcatgtt 1487641 atgatataca tcggctaaaa acgacacccc gagtaggacg agagatgatt ctcgttctgc 1487701 tctctttttt gggccctaat gagtctgccc gtttgcctga tttgatcaaa atatgaattt 1487761 ttcataaaaa cgaatctata tattgtgttt ttgctagagg gtagtatact atatatagtg 1487821 ttagtgatga gagattcata ttttttgata ggtcgtgata aaacgtggta caaatcatat 1487881 ttgattcgaa aacagggaat gttcagcggt ttgtgaataa aacaggcttt cagcagatac 1487941 gcaaggtgga cgaaatggac cacgtggaca ctccgtttgt tttggtcacc tacacgacaa 1488001 acttcggcca ggtaccggca tcaacacaat catttctcga aaaatacgcc catctcttat 1488061 tgggagtcgc tgcgagcggc aacaaagtat ggggcgataa ctttgcaaaa agcgccgata 1488121 ccatttcaag acaatatcag gtgccgatct tgcacaaatt tgaactcagc ggcacatcta 1488181 aagacgttga attgtttact caggaggtag aaagagttgt cacaaaatca agtgccaaaa 1488241 tggatccagt taaataacga aatcatgatc caaaaagatg ggaaattcca gtttgataag 1488301 gataaagaag ctgtacatag ctattttgta gattatatca atcaaaacac agtcttcttt 1488361 cacaatttaa aagagaagct ggattatttg gttgaaaacc aatactacga agaggaattc 1488421 ttaagccttt attcttttga agacattaaa gaagtgttta agacagctta cgctaagaag 1488481 tttcgttttc cttccttcat gagtgcgttt aaattctata atgactatgc tttgaaaacg 1488541 aatgacaaga aaaaaatcct cgagcgttat gaggaccgga tctcaattgt tgcgctgttc 1488601 ttcgctaacg gcgacactga gaaagcaaaa gaatatgtaa acctgatgat caatcaagaa 1488661 tatcagccga gcacaccgac atttttgaat gccggcagaa aacgccgcgg tgaacttgtg 1488721 agctgcttct tgctcgaagt taatgattct ttaaatgaca tttcaagagc aatcgatatc 1488781 tccatgcagc tttctaagct tggtggcggg gtttctctta acctgtccaa gcttcgcgcg 1488841 aaaggtgaag ccattaaaga tgttgagaat gcgacaaaag gcgttgtagg cgtcatgaag 1488901 cttcttgata acgcgttccg ttacgctgac caaatgggac aaagacaagg ctccggcgcg 1488961 gcgtatttaa acattttcca ccgcgatatc aatgattttc ttgatacgaa aaagatttct 1489021 gcggatgaag atgtgcgtgt caaaacgctt tcgatcggtg ttgtcattcc ggataagttc 1489081 gttgagcttg cacgcgagga caaagcggct tatgtattct acccgcacac gatttataaa 1489141 gagtacggcc agcacatgga tgagatggac atgaacgaaa tgtacgacaa gtttgtcgac 1489201 aaccctcggg tgaaaaagga aaaaatcaac ccgcggaaac tgcttgaaaa attggcgatg 1489261 cttcgttctg aatcaggcta tccatacatc atgttccaag ataacgtcaa taaagtgcat 1489321 gcgaataacc atatttccaa ggtcaaattt tctaaccttt gctctgaagt gctgcaggca 1489381 tctcaagttt cttcatacac agactatgat gaagaagatg aaatcggtct ggatatttcc 1489441 tgcaacctgg gttcgcttaa cattctcaat gtcatggagc ataaatcaat cgaaaagaca 1489501 gtcaagcttg cgacagactc tttaacacac gtgtctgaaa caacagacat ccgtaatgcg 1489561 cctgctgtaa gacgggcaaa caaagcgatg aaatcaatcg gcctcggtgc tatgaacctt 1489621 cacggctacc ttgcgcaaaa cggcattgcg tatgaaagtc cggaagcgcg tgactttgca 1489681 aacacgttct ttatgatggt gaatttctac tccatccagc gttctgcgga aatcgcaaaa 1489741 gagaagggcg aaacgtttga tcaatatgaa ggatcaacct atgcgacagg tgaatacttc 1489801 gacaaatacg tttcaactga tttctcaccg aaatacgaaa aaatcgctaa tctgtttgaa 1489861 ggtatgcata tcccgacgac agaggactgg aaaaagctaa aagcatttgt cgctgaacac 1489921 ggtatgtatc acagctacag attatgcatt gcgccgacag gctctatctc atacgttcaa 1489981 tcaagcacgg cgtctgttat gccgattatg gaacggattg aagaacgaac atacggcaac 1490041 tcaaaaacgt actacccaat gcctgggctt gcatctaata actggttctt ctataaagaa 1490101 gcctacgata tggacatgtt caaggttgtg gatatgatcg ccactatcca gcagcacatt 1490161 gatcagggaa tcagctttac attgttctta aaagacacaa tgacgacccg agatttaaac 1490221 cgaatcgatc tgtatgcaca tcatagagga attaaaacca tttactatgc aagaacgaaa 1490281 gatactgggc aagacagctg cctttcttgt gttgtttgat taaaggagag tttatagtga 1490341 caaaaattta tgacgcagca aactggtcaa agcatgaaga cgattttacc caaatgttct 1490401 ataaccaaaa cgtgaaacag ttctggcttc cggaagagat tgctttaaac ggcgatctcc 1490461 tcacatggaa gtacctcgga aaaaatgagc aggacactta tatgaaggta ctggccggac 1490521 ttacgcttct tgacacagag caggggaata cggggatgcc gatcgtggct gaacacgtag 1490581 atggccacca gcggaaagcg gtgctgaact ttatggcgat gatggagaac gctgtccatg 1490641 cgaagtcgta ctctaatatt ttcatgaccc ttgcaccgac tgaaacgatc aatgaagtat 1490701 ttgaatgggt taaacaaaat aaatatttgc agaaaaaagc gcaaatgatt gtcgggcttt 1490761 acaaagccat tcaaaaagat gatgaaattt cactgttcaa agccatggtt gcttccgtct 1490821 atctggaaag cttccttttc tacagcggtt tctattatcc gttatatttc tacggacaag 1490881 gaaaactgat gcaaagcggt gagatcatta acctgatcct tcgtgacgaa gcgattcacg 1490941 gcgtgtatgt cggtctcctt gctcaggaaa tttataataa acagacagaa gagaaaaaag 1491001 cagagcttcg tgaatttgcg atcgacctcc tgaatcagtt atatgaaaat gagcttgagt 1491061 atacagagga cttgtacgat caagtcgggc tctcacatga tgtaaagaaa ttcatccgct 1491121 ataatgcgaa taaagcgctg atgaaccttg gatttgatcc atacttcgaa gaggaagaca 1491181 ttaatccgat cgttttaaac ggattaaaca caaaaacaaa atcgcatgac ttcttctcta 1491241 tgaaggggaa tggctataaa aaagcgacag ttgagccgct caaagatgat gacttttatt 1491301 ttgaagatga aaaagagcag atataatatc tgctcttttc ggcttgaagg ttcaaatgag 1491361 gaggacgcag tacccatggg aaaaatggac gaaatgattt tagttgcccc gcgcgatgat 1491421 gtgtttaaaa aagaaagctt aaccttccag ggcgtgtaca gtgaagatag cagagtagca 1491481 gaaatcatgg ctcagattga agcggcctat cgtgaaatga gaagagggga cgcagaagaa 1491541 gatccgcgtt tcaagcagcc gataccttat gtcgtcatta agcgtgaaga tgaagttttt 1491601 ctttacgagc ggctggctgg cggcggtgaa tcacgtctgc acaacaagct ttctctcggt 1491661 tttggcggcc atatgaacgc catcgaaggg gcagcttcat ttgctgaagt cttaaagctg 1491721 aacacagacc gtgagcttga ggaagaactg caaataaatg aagaagataa acaggcgatt 1491781 gtcacactgg gattgatcaa tgatgatgaa aacagtgttg gcaaagtgca tatcggtatt 1491841 ctttctgcgc ttcaattaaa gcctggcgca caagtggaag tgaaggagaa agaacaaatt 1491901 gcgggtaaat ggatgaaagt ttctgaatta aaacaggatg atatctacaa ccgtctggaa 1491961 acatggtcac agtttgttgt tgatattctt gaataaaaaa acccggtttc tcgcgatgag 1492021 gagccgggtt tttttatgag acgctcgtcc ccgtctcggc tatgattcta ggatcacaat 1492081 agcgtcaaag ccggcatttt tcgctctggc agcgagggtg tctgcattgt ctttggatga 1492141 aaatgcgcca atctgcactt tgtataatcc gtcctttaaa aggacaatcg agtcaaaacc 1492201 tttggcttcg gcattacttg cgagcgagtc ggcattcgct ttgactttaa atgcgccgat 1492261 ttgaacctta tataaccctg agctggaagt ctttttaagg ttaaaggctt gctccagccc 1492321 gtttgcatgt cctctcgcta agctttgaat aaaactgctc gttttcagct tatttgcatc 1492381 ggaaacggta tcaatgaagc cgttctcggt caagagggca ggcattgccg actcccttag 1492441 gacgtggaag ttcgctgttt ttttgccgcg atcggcaaag tcgacagctt gtatcacttc 1492501 agagtgaatt gtcgattgat aagtcgtcgt cggggctcct acatctggat aaatatagct 1492561 ttcaaaacct gtgcctcccc cggaattaac gtgaatggac aaaaagaaat ctgctcccca 1492621 gttatttgcg gcatttgtcc ggtcgtttaa gctgacatat tggtcgcttg tccggctcag 1492681 cagcagagaa acgccttcat attcattagt taatatcgta cgtaaggcta aagcgatttg 1492741 cagggttaac gttttctcct gaaggccatt acctgttgcg cctggatcag acccgccatg 1492801 gccaggatca ataaaaattt taaccatttt tcatcacctc attacaggat atgaaaaaac 1492861 acggcttctg cttgtacgat tatcattcaa ctgaaaaatg aggaaataac cctttcacat 1492921 ccagaaatta tttctcggga aagcgcacaa ttcaacatga agcgacaaca gatacggtcc 1492981 gacatgaaat ctgtgcatac gccatatgtt tgtatgtact atgggttcgg ttaacctgca 1493041 ctgattcctg ctggttttaa gctttgcgtt catattaaat caagcattta aaacgtaaat 1493101 tgatgaggaa agctcctttc attaaagaca ccgctttata aatcgaaaaa aagaaaaaca 1493161 cttcaggtat cttagggcgg gtaatacgtt tcgtacaaaa atcagcccgt tgtatgaaaa 1493221 agaaataatg agaaagaagc tcactataat actctgacaa aatgattaaa aacaaaatct 1493281 catggtttgt ccaccccatg tccgtgaata caataagaaa taaagtattt ctcgggaaag 1493341 cgcaggattc cttattgttc ccgaaaaaag caattgtttc gacacatgat aggcgtttgt 1493401 cacaatcggc atccgcttga atatcatata gagagaacag agaggtgaag atgttggagc 1493461 gcgctgtgac ttataaaaac aacggacaga tcaacattat tctgaacggg caaaagcagg 1493521 tgctgacgaa tgctgaggca gaggcggaat atcaggctgc attgcaaaaa aacgaagcaa 1493581 agcacggcat tttgaaggaa atcgaaaaag agatgagcgc attagttggg atggaggaaa 1493641 tgaaacgcaa catcaaggaa atatacgcct ggatttttgt gaaccaaaaa cgcgcggagc 1493701 aaggcttgaa ggttggaaag caagcgctgc acatgatgtt taaaggaaat ccgggaacgg 1493761 gaaaaacgac ggttgcacgg ctcatcggca agctgttctt tgaaatgaat gtcctgtcaa 1493821 aaggccactt aatagaagcg gagcgggctg acctggtcgg ggagtatatc ggacacaccg 1493881 cccaaaagac gagagattta atcaaaaagt cattaggtgg cattttgttt atagacgaag 1493941 cctactcgct ggcaagaggc ggcgaaaagg actttgggaa agaagcgatc gacacacttg 1494001 taaagcatat ggaagacaaa cagcatgagt ttattttgat actcgccgga tattcacggg 1494061 aaatggatca ttttctctcg ttaaatcccg gactccaatc aagatttccc atctccattg 1494121 attttccgga ttactctgtg acccagctca tggagattgc gaaacgaatg atcgatgaaa 1494181 gggaatacca gctcagtcaa gaagcggaat ggaaattgaa agattactta atgacagtga 1494241 aaagcacgac aagtcccatt aaattcagca atggacgttt tgtcagaaat gtgatcgaaa 1494301 aatcgatcag agcacaagcc atgaggcttt taatgggaga ccaatactta aaaagcgact 1494361 tgatgaccat caaaagccaa gatctttcca ttaaagaaga agcatctgga tctgcataga 1494421 cctctcagtt tttgagaggt ctgttttttg ctcgtatttc cgcttttcaa agcaatcgat 1494481 ttgtggtata cacatgcagg gtttggtatg ataatactac tgcccaatat gcaaaagaaa 1494541 ggaacatcca tttgaacgaa caagaaacga ttcaggagaa agccatttta gtcggatgtc 1494601 agctgccgca tatcacggat gagcattttg aaaattctat ggaagagcta gcatctctga 1494661 cgaaaacagc agacggaaaa gtactgacca gcgtcacaca aaaacggaac agggctgacg 1494721 ccgctacata tataggaaaa gggaaggtag aagagctgaa ggcactcgtg gaagagcttg 1494781 aagctgatct cctcatcttt aatgatgaac tgtcgccaag tcagctgaag tcattggcaa 1494841 cagcaattga agtgaagatg attgaccgca cgcaattgat attagatatt tttgcaaagc 1494901 gggcgagaac gagagaaggc aaacttcaaa ttgagctggc tcagctgcaa tatgcactgc 1494961 cgcgtctgac gggacaaggg atcaaccttt cccggcaagg cggaggaatt ggggcaagag 1495021 gtcccgggga aacgaaactg gaaaccgacc gccgccatat cagaaatcgc attcatgaaa 1495081 tcaacacaca gctttccact gtcattcgcc atagaagccg ataccgtgaa agaagaaaga 1495141 aaaacggtgt gcttcaaatt gcgcttgtcg gctatacaaa cgcagggaaa tcaacatggt 1495201 tcaaccgcct gacgagtgct gacagctatg aagaagacct cctgtttgcc acgctggacc 1495261 cgatgaccag aaaaatggtc ctgccaagcg gctacagtgt tcttctttca gatacagtag 1495321 gatttattca ggatcttccg acgacattga ttgctgcatt ccgctcaacg cttgaggaag 1495381 taaaagaagc ggatttaatt ctgcatttaa ttgattcttc aaatgaggat tatgcgggac 1495441 atgaaaaaac agtgcttcgg ctgcttgagg agcttgaagc agatgatatc ccgatgctga 1495501 cggcttacaa taaacgtgat caaaaactgc ctgattttat accgaccgcc ggaagggatc 1495561 acattatggt cagtgcgaaa tttgaggacg acgctgcagc ctttaaagaa gcgattcagc 1495621 gctatttgcg ccaagaactg ttaacgtctt ttgaagcaca tgtgccggca agtgaaggga 1495681 agctcctttc cagaatcaaa tcggaaacga tggtagaccg cttctatttt aatgaagaaa 1495741 atgaacagta tgacatatcc ggctatgtcc aagaagagca aagtatcatc ggtgaattaa 1495801 agaagtatat gtaggaagga aatataaaga catgtttgac acattaacac acggagaatt 1495861 attgaagaaa acggcaatgg aagtggaagc ggacattgcc ggcattcata aacaaataga 1495921 agaaatcagc gagcgaaatg agtggagagt gcttcaaagc tatagaaaac acaaagtaag 1495981 cgacactcat ttcacgccgt ctactggata cggctatgat gatatcggaa gagacacgct 1496041 tgaaagcata tatgcggatg tgtttggcgg agaagcgggg cttgtaaggc cgcaaatcat 1496101 ttcaggcaca catgccatct caattgcttt gttcggtgtc ctcagaccgg gggacgagct 1496161 cctttatatc acgggcaagc cgtatgatac gctagaggaa attgtgggcg tcaggggtgg 1496221 agaaaacgct ggttcgttaa aggattttca aatcggctat aatgcggttg atctgacgaa 1496281 agacggaaag atagactatg atgcagtcgc cgctgcgatc aatccgaaga caaaagtaat 1496341 cggcattcag cgctcaaaag gatatgcgaa tcgcccttct ttcttaatta gtgaaataaa 1496401 agaaatgatc cgttttgtaa aagaaatcaa tgaaaatctg atcgtctttg tggacaactg 1496461 ttacggagaa tttgtggaag agcttgagcc ttgccatgtc ggagccgacc tgatggcggg 1496521 atctctcatt aaaaatcccg gcggcggcct tgcgaaaaca ggcggctacc tcgtcggaaa 1496581 agcgaaatgg attgaagctt gctcataccg tatgacgtca cccggcatcg gcagagaagc 1496641 gggggcatct ctttactcgc tccaagaaat gtaccaaggc ttctttttgg cgcctcacgt 1496701 tgtgtctcaa agtttaaagg gagcggtgtt tacagcgaga ttccttgaaa aactcggctt 1496761 cacttcaaac ccgaaatggg atgcgaaaag aacggattta atacaatccg ttgagttttc 1496821 tgacagagaa aagatgattg ctttttgcca ggctattcaa tttgcatcgc caatcaatgc 1496881 tcatgtgacg ccttatccag cctacatgcc tggatacgag gatgatgtca ttatggcagc 1496941 agggacgttt attcaaggag caagcatcga attatcagct gatggcccta tccgcccgcc 1497001 gtatgtagcg tatgttcagg gaggattaac ctattcgcat gtgaagaatg ccatatgcag 1497061 tgcagtggat tcattgatgc aaaagcaatt aatttaaatt ttttaaaaat ttctctggat 1497121 ttgatgttaa gaatccttac atcgtattga cacataatat aacatcacct ataatgaaac 1497181 taagttaaga aaaggaggaa attgagatga gtgataatat tcgccgctca atgcctttat 1497241 ttccaatagg aattgtcatg cagttaactg agttatcagc aagacaaatt cgatattatg 1497301 aggaaaatgg actgatattt ccagccagaa gtgaaggaaa tagacgatta ttttcatttc 1497361 atgatgtaga taaactgtta gaaatcaagc acctgataga acaaggtgta aacatggcag 1497421 gaattaaaca gattctggcg aaagccgaag ccgagccaga acaaaaacaa aacgagaaga 1497481 cgaaaaaacc aatgaaacat gatctgtccg atgacgaact gagacagctc ctgaaaaacg 1497541 agctcatgca agccggccgt tttcaaagag ggaatacatt ccgtcaaggc gacatgtccc 1497601 gcttctttca ttaatccgtt agcaactgtt ttgctatata catttacctt ttaagaggag 1497661 gaattttacc aaatggcaaa gtacactaga gaagatatcg aaaaattagt aaaagaagaa 1497721 aacgtgaagt atatccgcct tcaatttact gacattcttg gaacaatcaa gaatgttgag 1497781 attcctgtaa gccagcttgg aaaagcgctt gataataaag tcatgtttga cggttcttct 1497841 attgagggat tcgttcgtat cgaagagtca gacatgtacc tgtatccaga tctaaataca 1497901 tttgttatct tcccatggac agctgaaaaa ggtaaagtag cacgtttcat ctgtgatatt 1497961 tacaatccgg atggcacacc ttttgaaggt gacccgcgaa acaacttaaa acggattctg 1498021 aaagaaatgg aagacctcgg cttcagtgat tttaaccttg ggcctgagcc tgaattcttc 1498081 ttattcaaat tggacgaaaa aggcgagccg acgcttgaac taaacgacaa aggcggatat 1498141 ttcgacttag ctccaactga tttaggagaa aactgccgcc gcgatatcgt acttgagctt 1498201 gaagagatgg gctttgaaat cgaagcgtct caccacgaag tagcacctgg tcagcacgaa 1498261 atcgacttta aatatgctgg agcagtccgc tcttgtgatg acatccaaac atttaaacta 1498321 gttgtcaaaa caattgcccg taaacacggc ctgcatgcga catttatgcc aaaaccattg 1498381 ttcggtgtaa acggttcagg tatgcactgc aatctatcac tcttcaaaaa tggtgttaac 1498441 gcattctttg acgaaaacgc agatcttcag ttaagtgaaa cagcgaagca cttcattgca 1498501 ggtatcgtga agcacgcaac aagctttaca gcagtaacaa acccgacagt aaactcttac 1498561 aaacgtcttg ttcctggcta tgaagcacct tgttatgtag catggagcgc gcaaaacaga 1498621 agcccgctta tccgtatccc ggcttctcgc ggcatcagca cacgtgttga agtacgcagt 1498681 gtagacccag ctgcaaaccc ataccttgca cttagcgtat tgcttgctgc aggattagac 1498741 ggaatcaaaa acaaactgga agcgccggct ccaatcgacc gcaacatcta tgtgatgagc 1498801 aaagaagagc gcatggaaaa cggaatcgtt gaccttccag caacacttgc ggaagcacta 1498861 gaagaattca aatcaaacga agtcatggtc aaagcgctgg gcgagcacct attcgaacac 1498921 ttcatcgaag caaaagaaat cgaatgggat atgttccgca cgcaagtaca tccttgggaa 1498981 cgcgaacagt atatgtctca gtattaatat ctcaatccct tggcactaaa agtgtcaggg 1499041 gattttttat gttaataggt aataaattat ggagcggcat agtgtttaac acagccatta 1499101 atcctcagac agtcaaatag ccatttctac tccggttgaa agcttctcta tttttgcttc 1499161 ttatttatct ttcctgtatt gatatatgta tgtagggttg gacttataac ataaactatt 1499221 ctggccattc cgttctttca attcatgacc gggcttgcca tcagcataaa tctaggctaa 1499281 cagtctccat acatcctgtg atcaccttta tcaaactctt aaatgcaact taccactaac 1499341 caattcttta tttcgcatag atcatctttg tcatgtgttt acacaagaat ctgttttgga 1499401 ctgagacact gaatataaca aaacagtcaa aaatcaatat ttaattcatt ctgtttaaac 1499461 tttctgaaaa agatgttgaa aaagtcgaaa ggattttata atattaagtc aagttagttt 1499521 gtttgatcaa caaactaatg aaatgaactt tcattatcca caagataaga tcttactaat 1499581 atggatggaa gggggataag agggtcgatt taatggagct aaacaatata agaaacgaaa 1499641 gaatgaggct tttatccttt tccaggtata taaggtatga cgaaaaaaga tgaatttttt 1499701 gcttgctgat caccatattt ttttgcactg ttttgaaagc gcttttataa aagtttactg 1499761 accgtaaatt cgagaaattg ttataccgtt tcacactgtt ccatattaaa ggatcgaaaa 1499821 ggggagaaat catgctcagt gaaaatgtaa agaagattag catggttgaa aaagttggat 1499881 atgcgtctgg agattttgct tgtaatttaa tttatgcaac agtgtctacg tatcttttgt 1499941 tcttctatac agatgttttt ggtttatcgg cagcagcagc cggtactatg tttttagtgg 1500001 ttagaataat cgacgctctc gctgatcctt ttatcggaac aatagttgac agaacgaaca 1500061 gcagatttgg acgctttaga ccgtatcttt tattcggagc ttttccattt gtcatactgg 1500121 caatactctg ttttacaaca ccagactttt cggatatggg gaaattaata tatgcctata 1500181 taacctatgt tggcttgtcg cttacataca caacgataaa cgttccatat ggcgcgttaa 1500241 cttctgcaat gactagaaat aatcaagaag ttgttagtat aacttctgtt cgcatgttat 1500301 ttgcgaatct tgggggactt gtcgttgcat tttttgttcc cttactggct gcttatttaa 1500361 gcgatacttc cggcaacgag tctcttggct ggcaactaac catgggtatt ttgggaatga 1500421 taggcgggtg ccttttaatc ttttgtttta aaagcacaaa agagcgggtc actcttcaaa 1500481 aatccgaaga gaaaattaaa tttacggata tatttgagca gtttcgtgtt aatcgtccac 1500541 ttgttgtatt aagtattttc tttattatta tttttggagt gaattccatc agtaattcgg 1500601 ttggcattta ctacgtaacg tataacttag aaagagagga tttggtgaag tggtacggtt 1500661 tgataggaag tttacccgct ttggtcattt taccgtttat tccaaggctt catcaatttt 1500721 tggggaaaaa gaaattacta aactatgcat tattactgaa tattataggc ctcttagctt 1500781 tactgtttgt tccgccaagt aatgtttacc tcatacttgt ctgtcgatta atcgctgctg 1500841 ctggaagtct cactgccggg ggatatatgt gggcgcttat tcctgaaaca attgaatatg 1500901 gagagtacag gactgggaaa agaatgggtg ggctcattta cgctataatc ggatttttct 1500961 ttaagtttgg tatggcctta ggaggagttg ttccgggtct ggttcttgat aagtttggat 1501021 atgtagcaaa tcaggcacaa accccggcgg ccttaatggg gattttaatt acaacaacca 1501081 ttattcccgt gttcttgctt gttctagctt taattgatat taatttctat aacttagatg 1501141 agaaaaaata taaaaacatg gttcgagaat tagagaatag agacaaagtt tatttggatc 1501201 atattgatga tttcaaggct taaaaaagaa aataaactga ggaggagtcc caaatgaaga 1501261 ttaccaatcc cgtacttaaa ggattcaatc ccgatccaag tatttgtaga gcaggagagg 1501321 attattatat cgctgtatct acatttgagt ggtttccggg agtccagata caccactcaa 1501381 aagatttagt aaattggcac ttagttgcac atccattaca gagagtttca caattagaca 1501441 tgaaaggaaa cccaaattca ggtggagttt gggcaccatg tttaagctat agtgatggga 1501501 agttttggct gatctatacg gatgttaagg tagtagatgg cgcatggaaa gattgtcaca 1501561 attatttagt tacttgtgaa acgattaatg gtgattggag tgagccgatt aaattaaata 1501621 gctcggggtt tgatgcttct ttgttccatg atacggatgg aaaaaagtat ttattaaata 1501681 tgttatggga tcaccgtatt gatcggcact catttggagg aattgttata caggaatatt 1501741 ctgataaaga gcaaaaatta atcggtaaac caaaagttat atttgaagga actgatagaa 1501801 aactgacaga agctccgcat ctttatcata tcgggaacta ttattattta ttaactgcag 1501861 aaggaggaac acggtacgaa catgctgcta caattgctcg ttctgcaaat attgaggggc 1501921 catatgaagt tcatcccgat aatccaattt taacgtcatg gcatgaccca ggaaatccat 1501981 tgcaaaaatg tggtcatgca tccattgttc aaacacatac agatgagtgg tatttagctc 1502041 atttaacggg acgtcctatt catcctgacg atgattcaat ttttcagcag agaggatact 1502101 gtcctttggg cagagaaaca gctattcaaa aactttactg gaaagatgaa tggccctatg 1502161 tagtaggtgg aaaagaagga agcttggagg tagatgcacc ttctataccc gaaacaatat 1502221 ttgaagcaac gtacccggaa gttgatgaat ttgaggattc aacattaaat ataaattttc 1502281 aaactttaag gattccattc acgaatgaat taggttcatt gactcaagcg ccaaatcatt 1502341 tacgattatt cggtcatgaa tcattgacct cgacatttac tcaggcattt gtagccagac 1502401 gctggcaaag tctccatttt gaagccgaaa ctgctgttga gttttatccg gaaaattttc 1502461 aacaagccgc tgggttggtg aattactaca atacagagaa ctggacggct cttcaagtca 1502521 cgcatgatga agaacttggg cgcattcttg aattaacaat atgtgacaac ttttcttttt 1502581 cacagccatt aaataataaa attgttattc ctcgtgaagt aaagtatgta tatttaagag 1502641 taaatattga aaaggacaaa tattattatt tctattcttt taacaaagaa gattggcaca 1502701 aaattgacat tgcactggaa tcgaaaaaat tatcagatga ttatatccgt gggggaggat 1502761 tcttcacagg ggcctttgta gggatgcaat gccaagatac cagtggtaat catattccgg 1502821 ccgactttag atattttcgt tataaagaaa aataatttgc acatgaaaaa ggagatttct 1502881 attttagaac tcctttttca tatgagaagg tgccatgtca ctattgcttc agaaatactc 1502941 ctagaataaa aaaactcatc tttaaagatg agctgtccat tccataaaaa attacattgt 1503001 aatcatgtcc agaaaatgat caatcacaat ggaggacatt cctaatgccg gtgcattctg 1503061 tcctaaggaa gatggcaata attcatagct attgcctaat tgggaataaa cccttgatga 1503121 tacttcactt ctcattgaat ttaaaaccat aggatgcgat tcaattatgc tatttcttaa 1503181 aattacggct tgtgggttga aagtatttag aatattggta aggcctattc ctaaatagaa 1503241 tccaaaattt tgtaatgcat ttaaggttcc gatatcattc agatgggcga ggtttatgat 1503301 atcttgatag gacagttttt tctctttggt ctgaagagat tttaataaag ccttctctga 1503361 agcatacaat tcccagcatc ctcggtttcc gcaactgcat ttaggaccat taaagtctat 1503421 tgtcatatgt cccatttctc cagagaagcc gcttactcct ctatataaat gattgttgat 1503481 aataacaccg atccctattc ctgtgctgat acttacgtaa ataatgttat cgtgattttt 1503541 tgcagctcca aatacttttt ctccatatgc gccagcattt gcctcatttt caataaaaac 1503601 aggcacattg tacttctctt gtatcgaaga ttttaagtca atatctctcc agttggagtt 1503661 cggagtgaaa acaatttttt gatctttatc aatgagtcca ggcacgcaaa tacctatacc 1503721 aataagcccg tacggagatt ggggcatttg cgtaataaag tgatgaatca tatcaatcaa 1503781 aatgtctttc gttatttctg gagaattgga ttccaaatgg cggtattgat caagaacgat 1503841 tgttccttca aggtctgtta aaatgccatt aatataatcc acaccaacat ctattccaac 1503901 ggagtatcct gcctttttat taaaaacaag catgacaggt cttcttccgc cacttgattg 1503961 tccttgacct atttcaaata ccatactttc tttcattaac gtgtttacct gtgatgagac 1504021 agttgattta tttaatccag tcatttcaga taattttgct cttgaaatag gtgaattttt 1504081 aaggatttct tttaataata acttttgatt tacttttttg acaaaggttt gatcagcgat 1504141 atccacttca tccactccat ttgtttaatc tttaaattaa gtatcaacat agtacatagc 1504201 gaatcttccc tttattatat ctaatgtgtt cataaaaaac taaaaaaaat attgaaaata 1504261 ctgacgaggt tatataagat gaaaataagt tagtttgttt aaacaacaaa ctaataggtg 1504321 atgtacttac tatatgaaat aaaatgcatc tgtatttgaa tgaatttatt tttaaggggg 1504381 aaatcacatg gctcaatctc attccagttc aatcaactat tttggaagcg caaacaaagt 1504441 ggtttacgaa gggaaagatt cgactaatcc tttagcattt aaatattata atcctcaaga 1504501 agtaatcggc ggaaaaacgc tgaaagagca tttgcgattt tctattgcct attggcatac 1504561 atttactgct gatggtacag acgtttttgg agcagctacg atgcaaagac catgggatca 1504621 ctataaaggc atggatctag cgaagatgag agtagaagca gcatttgaga tgtttgaaaa 1504681 actagatgca ccattctttg cttttcatga ccgggatatt gcaccagaag gcagtacgct 1504741 aaaagagaca aaccaaaatt tagatatgat catgggcatg attaaagatt acatgagaaa 1504801 tagcggcgtt aagctattat ggaatacagc aaacatgttt acgaatcccc gtttcgtcca 1504861 tggtgccgcg acttcttgca atgcagatgt gtttgcgtat gctgcagcac aagtgaaaaa 1504921 agggttagaa acagcaaaag agcttggcgc tgagaactat gtattttggg gcggccgtga 1504981 aggatatgaa acattgttaa ataccgattt aaaatttgag cttgataatt tggctagatt 1505041 tatgcatatg gcagtggatt atgcgaagga aatcgggtac acagggcagt ttttgattga 1505101 gccaaaacca aaagagccga ccacccatca atacgataca gatgcagcaa caaccattgc 1505161 ctttttgaag caatatggct tagacaatca ttttaaatta aatcttgaag ccaatcatgc 1505221 cacattagcc gggcatacat tcgaacatga attacgcatg gcaagagtac atggtctgct 1505281 tggctctgtt gacgcaaacc agggtcatcc tcttttaggc tgggacacgg atgaatttcc 1505341 gacggattta tattctacga cattagcaat gtacgaaatc ctgcaaaatg gcggccttgg 1505401 aagcggcgga ttaaactttg acgcgaaggt cagaagatct tctttcgagc ctgatgatct 1505461 aatatatgcc catattgcag ggatggatgc atttgcaaga ggattgaaag ttgcccacaa 1505521 attaatcgaa gatcgtgtgt ttgaagatgt gattcaacat cgttaccgca gctttactga 1505581 agggattggt cttgaaatta tagaaggaag agctaatttc cacacacttg agcaatatgc 1505641 gctaaatcat aaatcaatta aaaacgaatc tggaagacag gagaaattaa aagcgatatt 1505701 gaaccaatac attttagaag tataacagga taagctccag atcctgctat caataccaag 1505761 tcactgaatt acccgtcatg attcctttcc tattgcttgt tgttatgacg ggtaacttct 1505821 ataattagga tttatttaga gtgaatggtt ttttaaaagg gcaaggagtg aaaaaatgaa 1505881 gtatgtcatt ggaatagatc ttggaacgag tgctgttaaa accattttag ttaaccaaaa 1505941 cggcaaggtt tgtgcagaaa cgtccaaaag gtatccgctc atccaagaga aggcgggata 1506001 tagtgagcaa aatcctgaag actgggttca gcaaacaatt gaagcattgg ctgaattggt 1506061 ttctatatcc aatgttcaag ccaaggatat tgacgggata agctattcgg gacaaatgca 1506121 tggattagta ctgcttgacc aagatcgtca ggtgttacgt aatgcaattc tttggaatga 1506181 taccagaaca acgcctcaat gtataaggat gaccgagaaa tttggcgatc atcttcttga 1506241 catcacaaaa aaccgtgttt tagaagggtt tacattacct aaaatgttat gggtaaagga 1506301 acatgaacct gaacttttta aaaaaactgc tgtgtttttg cttccgaaag actacgtgcg 1506361 attccgtatg accggtgtca ttcacaccga atactccgat gcagcaggaa ctttactttt 1506421 acatattact cgcaaggagt ggagcaatga tatttgcaat caaattggta tttctgcaga 1506481 tatttgtcct ccgcttgttg aatctcatga ttgtgtagga tcgctgcttc cgcacgttgc 1506541 cgcgaagacc gggctattag aaaaaacaaa agtgtacgct gggggagcag ataatgcttg 1506601 cggcgctatt ggagcaggta tcctttcttc cggaaaaaca ttatgcagta ttgggacgtc 1506661 aggggtcata ctttcctacg aagaagaaaa agaaagagac tttaaaggga aagtccactt 1506721 ttttaatcat ggaaaaaagg attcttttta tacgatgggc gtcacgctcg ctgcaggata 1506781 cagcttggac tggtttaaaa gaacgtttgc accaaacgaa tcgtttgagc aattattgca 1506841 gggggtggaa gctattccga taggagccaa tggactgcta tacactcctt atttggttgg 1506901 tgaaagaacg ccgcatgctg attcttctat tcggggaagc ttgatcggaa tggatggagc 1506961 ccataataga aagcattttt tgagggcaat aatggaaggt atcacattct ctttacatga 1507021 atcaattgag ctattccgcg aagcgggaaa atcagttcat actgttgttt ctattggtgg 1507081 gggagctaaa aatgatacgt ggctgcaaat gcaagctgat attttcaata cgagggtaat 1507141 taagttagaa aatgaacaag ggccagctat gggggctgca atgctggctg cctttggaag 1507201 cggttggttt gaatcacttg aagaatgtgc agagcagttc attcgtgagg ctgctgcatt 1507261 ttatccaaag gcgcaaaatg ttcaaaaata taaaacacta tttgatttgt ataagaacat 1507321 ttacactcac acaaaggatc tcaatacagc tttgaagagc tttcgaaaaa actaatgatg 1507381 ttattgtctg gagatcaacc gaagaacaat taatgatcaa tcatcatcaa aggcctttga 1507441 taacatggct gccttctttt gaaaagatgg tgagaataag gtatcgcaac ctttaaacag 1507501 tattggagta tccagcagac aaaacgaacg agtggaaccg tattttgtca gcgaacactt 1507561 caagaagtgg ggaagcttag gaatgccaat gggtaagatg tatgaaaccg cgctaacgac 1507621 ggtagaggga tctcttgatt tatgaagaaa taggaaggat gttaacacac aaataacccc 1507681 tcacattgac gtgaaggggt gttttttatt gttactatac agcggaaatt ttacaggcta 1507741 gttgcatgat tttagcttgt taagcagaat ggaactagac tctccatcat ctctttctca 1507801 ttctttggaa actgcattct gctaggtttg ctgctttttt taacaaacag tgtttttcta 1507861 tttcacacag ccattaaatc ctctgttcgt cacataaccg ctcttactcc aaattgacag 1507921 tttatctgat tttgcttctt gctcatctag tctgaattgg tctatgtatt ttgtgttagg 1507981 ctcatataca tatgctactc tggccaatcc ctctttcaat aatgtctctt gaacagattt 1508041 gccgtcaaca taaacgtatg ctaacagtct tccatactta tctctgcgat cgcctttatc 1508101 aaattccagc tgtagcttac cgctgttgac caattcttta tttcgtttcg acgcatcctc 1508161 accgtatggt tgaacacaag aatttggttt cttcgtctca ggtgtatcaa cgagcaagta 1508221 gcgaactgtg tctttctttc cgttgtaaat aaccttaatc gtatctccat ctattgctct 1508281 atctaatgta acattgacca atttcttctg attttttgaa tgaggcgtgc cagccttttg 1508341 ttctgtctga ttatattcat tagagtgagt atcttgagag acttgctccg tcccattaga 1508401 atctgaatgg tttttggctg cgtgatttga tccgcaagct gccaaagtaa tacttaaaac 1508461 gattgcgatc atactgatca aaatcttctt catattgatt ccctctttat cattttctct 1508521 tttcgcgatt aaacatcatc attataacga tatggacatt ttttgtgaat ggaaaacttc 1508581 aagggaactt ataacactcc aaattgccaa tagttaactt cacaacgaga tgatcaaaac 1508641 atcaccatca catagcggaa ataaataatc ctgaaaataa tattgactga aaatgctttt 1508701 agaattatga taatatgaga aatgacaata atgtgacaaa gacattacta caacataaca 1508761 actaatagct taggtttatt ctattggtta aaaatgtaaa cggttacaaa tccagaggcg 1508821 aaaatctaag atagagatga ctttagtttt gactcaatat ccacactgaa agagcttatt 1508881 aagtattctt aaaggcaggg gaaatggata tgaatgaaca tcgaaatcga aggttgaaat 1508941 taataatgat ttcagcaact tttggagggc ttctctttgg atatgacacc ggagttataa 1509001 atggagcttt accttttatg gcaaggccag atcagcttga tttaacacct gttacagaag 1509061 ggcttgttac gagtattctt ttattaggtg ccgcgtttgg agcgttgtta tgcggaagat 1509121 tggctgatcg atatggccgc cgtaaaatga tccttaatct ttccttttta tttttcctgg 1509181 catcactggg aacagcgtta gcacctaatg ttttcatcat ggcggtcttt cgttttttac 1509241 tggggctggc tgttggagga gcctcggcga tggtgccggc ctttttagca gaaatggcac 1509301 cgcatgaaaa gagagggcgt atggtaaccc aaaatgaact aatgattgtt ggcgggcaat 1509361 ttttagcata tgtttttaat gcgatcctcg gtgtaacaat ggcaaatacg ggacatgttt 1509421 ggagatacat gctagtcatt tgtgctgtac cggctatcat gttatttgcc agtatgctta 1509481 aggtaccaga aagcccccga tggctaatct ccaaaggcaa aaacagtgag gcgctgcgag 1509541 ttcttaaaca aattcgagaa gataaacgtg cagaagctga atgtagagaa attcaagaag 1509601 cggtagaaaa agatacagca ctagaaaagg catcactcaa ggacttttct acaccatggc 1509661 tgcgccgtct tttatggatt ggaatcggtg ttgccatcgt gaatcaaatt acaggtgtga 1509721 actcgattat gtattatggc acacaaatcc ttaaagaatc tggttttggt acaaaagcgg 1509781 ctttaatcgc taatattgga aatgggctga tatcagttat tgcagttata tttgggattt 1509841 ggctggtcgg aaaagtgaga cggcgtccaa tattattgat tggtttggca gggacgacta 1509901 cagcgctcct attgattgcg attttctcaa ttgtgcttga tggatctatg gcacttcctt 1509961 atgtagtgct ttctttgacc gttttatttc ttgcctttat gcaagggtgt gtaggacctg 1510021 tgacttggct tgtcatagcg gaaatattcc ctcaaaggtt aagaggactt ggttctggga 1510081 taagtgtttt tttcctttgg atattaaact ttgtgatcgg ttttgctttc ccgatcttgc 1510141 ttagctctgt aggtttgtct tttacattct ttatatttgt ggctttaggt gtattggcaa 1510201 tcggttttgt gtacaaattc atgccggaaa caaaagggcg tacacttgaa gaattagaag 1510261 agcattttcg ttctcgacac gatcataata ctcctgaaca atcagttatt gaggtataaa 1510321 tatgttgaaa atctctcttc ttataggagg gattttttta gtttcagaaa aaacaaaatc 1510381 cctctggtag agggattttg attcagcatt ttaagatgtt ctacacgtat aatactggag 1510441 ttgatacttt aaaaatctcg ccatctctta tataaaaacg agggatgcgg cggcttaatg 1510501 tagacacgac ttcatagtta atcgtattga gcatttcagc cacttcatca acggaaatct 1510561 cggctccttt ttgcttaccg taaatcacga cttcatctcc ttgtttacct tcaccgtttt 1510621 ctcctaaact gaccatgatc atatccattg ttactcttcc cgccactggc actcgttttc 1510681 cgcgatgaag aacaaacccg cgattggaaa gggcacgaga atagccgtca gcatagccaa 1510741 tcgggagtgt agcaattact tcattaggtt ctgcgatgta tgtagcacca tagctaacgg 1510801 ttcggggttc tgtccgcatg gttttcacat aagcgatgcg tgcctttaaa cttaacgcag 1510861 gttcaagctt aacgagattt agttgtttaa tataggctga aggatataaa ccatataagc 1510921 cgatacctaa acggatcata tcagcgctaa attccggaaa tgcgatagct gcagccgtgt 1510981 tgcacatatg cacggtgggc agctcaatcc cctgtttttt taaaaagctg agaaaactga 1511041 tgaatttttc atgctgcagc tttgtgagtg ttgtgtccgg ttcatcagct gtcgaaaaat 1511101 gtgtgaaaat ccctgtccat ctgaggaatt tacttgcctt taaggctttc actacctcta 1511161 aaagttcttc ctttgtgcgt acacctaatc gtcccatgcc ggtatccacg ttaatatgaa 1511221 tggccagccg gttagcactc gcttcttttt ccaatatctc gtttgcttct ttcatccaat 1511281 caacctgaaa tgctgataat gttatattcc aagctgctga cttctttaca caactaaggg 1511341 atgtaaaacc aagcacaagg ataggtgctg taatcccagc tttacgtaaa acgattcctt 1511401 cctccacact ggcaacagcg agctcactcg ccccgtgttc cagtgcatgg cgtgccactt 1511461 ctatagaccc gtggccataa ccgttcgctt ttacaacagc cataattttg ctcttatgtg 1511521 gaatatgacg gcggatcgct cgcaaattct ttttaacggc atcaagattg acttcgatcc 1511581 aaacttctcg gcaaagcttt atcatcaacg cttccttcct tcttatggat tataaatacc 1511641 acctattgcc gcaagaataa atgttaattg ttggatgatt cgatcttatt ttattcaact 1511701 ttatttgaaa tcattcaaca gcaaatccat gtgatacgag aaggtgccta tcaatgttcg 1511761 aataatagca agtacgggat acatgaggct tgtaagtggg gtgttaatgg atgcggcgac 1511821 cgaggattac aaaaatgatt atttgttttg ggacattttt ttctaagggt agatgataac 1511881 gagaaatcta atcaggaaat acttaccgtt gttatgaaca ttgaagaacc ttttaaatga 1511941 gaagggctga ggaaattctg taaaagataa tcggttgaaa aggcagtcga ttccttgttc 1512001 cataaaccta acatcagagt atataattat actcgtattc acaaaaatcg tttaagtaag 1512061 gggtatacat gaatagggga gttagttttc aaataccgaa tgaatatgga aattttctat 1512121 ggagaatact gcagccggta gaaatagcta attataggtg gcaaacgagt ggggaatctt 1512181 attttgttgt agaaggagag ctcgatgatg aggagctttt tcatgactac gaaattgttg 1512241 agggggcagt ttttgagcaa caattaaaaa cgaatcagta ctataccatt ttcgttgaac 1512301 tgaaagcatt tccatatgga aaaatggtta atcaagtcaa tacatatgaa gagtttgctg 1512361 acagtgattg cgaacttgtc cttttgatag cagataatag ctacgtttcg atttactgta 1512421 aaaacaaaaa tatcattgaa aaactttact tcaatgcttt acagcatgat tttgaagacg 1512481 ttcaatttat aactgatgaa aatgacacaa gaacaagcct tactgtatga tactcaataa 1512541 aaattaaagg agctagtaca tgacaatgca aattaaaatc aagtatctag atgaaacaca 1512601 aacaagaatc agcaaaattg agcagggaga ctggattgat cttcgggcag ctgaagatgt 1512661 aacaatcaaa aaagatgaat ttaagcttgt cccattaggt gttgcaatgg agctgcctga 1512721 aggttacgaa gcacatgtcg tccctcgttc aagtacatat aagaactttg gcgttattca 1512781 aacaaattca atgggtgtta tcgatgagtc atataaggga gacaacgatt tctggttctt 1512841 tcctgcttat gcattgcgtg atactgaaat taagaagggt gatcgtatct gccagtttag 1512901 aatcatgaag aaaatgccgg cggttgaatt ggttgaagtc gagcatttgg gaaacgagga 1512961 tagaggagga ctcggttcaa caggtacgaa gtaaacaaaa taaatccttg gctgtcttca 1513021 tgctgtgtga ttgatcaatg gaggtttcag ccaaggtaca tataaatatt atgtataaaa 1513081 tgaatatttt aatacgaagg atttaattaa aaacaaagtt taaaaaggga agttttgaaa 1513141 aagtgaaata gtaataacta aagtcgataa agaacctaaa gatgtcaaag aaacaatttt 1513201 tctggtgctt tgcttttttg aaggtttact tagctcgtgg ataactgccc cccataaaag 1513261 catggatgct aaaattataa tacttatata cataaagatg ctccttttat tatatttaca 1513321 gtttttacat ttttatcgat tttaccacat ttaggattga gttgtcgatg aaacaagcat 1513381 ctctataaag aaatactttt atctaaattt ttataaatag gggaaggcaa ctaaaaacta 1513441 gtaatgccac taataataag ccaagttaaa tgacttgtgt tcattaataa ttgaatttta 1513501 cagcagccat gagcacaaaa aaatctgagt tcgtcgataa atatcataaa aaagcccccg 1513561 gtatgtcgcc agggaataaa tagacgttta agagatttag tgatgttttt tatatgattc 1513621 gacaaaatca taataatgat catcgtcatc ataatacttt ttttcgtaat gataatcgtg 1513681 atcatcgtaa tactttttat catggtcatc atactttttg tcgtaatcat aatgtttttt 1513741 atcatgatca taatacttgt cgcaatcata atgcttctta tcattgtcgt aatacttttt 1513801 gtaatatgtt tttttccaag tataatactc ttctttatat tttttataat aacccaatta 1513861 aattcctcct ttatgttatt cgaatttaat ttatgaagtt taaatgatat ggtatggtca 1513921 aatgaaataa gaatagtaaa aagaggctgt ttaaaacact ttctgaaaaa caaaacggat 1513981 agctgtttat gaaaataaga gcgagagaga gcactcaatc actgtaaaat aatagtaaag 1514041 tgtatagaga gattagtata cgtaaaaagg gactttctca ttgaagaata tttgaacgtt 1514101 atggttaaga ttcaagagct ctatgatgtg atttttcaca ctgcttttga aggatttaga 1514161 gttagacatc aaaaacaaac agcaaaaccg gctagaaaca gatcatataa ggaatgaacc 1514221 gctgccaaat atcataaaaa agttgttaat gatcaaatga atgaaattag agagaattta 1514281 ttttaaagaa agcccaattg cacatggaca aatgacaatt gatattgagg taaaatacaa 1514341 tgcattaaat cagaaaaagc tattggagga tttaatgtgt ttagacaatt tccaatttgg 1514401 tatacacaaa cacctgacta tttgaatttt tatgtaccgc aatatcaaac catttcgtat 1514461 aatcctcaac aatgttatca acggtgtatg taccaaactg gcggtaacta tgagctatgt 1514521 gacagactat gttatggaga aatacaggtg taaaagaggg ggattaactc ctctttaaac 1514581 acacagtgag tggaataaga tcctcacttt atctgcaagt gcttagtatt tgcgataata 1514641 ttgcattcgt aataaattat gcttagcaac tgaaaatgaa agaaggatat gaatagtcat 1514701 gacgcaattc gataaacaat acaattcaat tataaaggat attatcaata atggaatctc 1514761 agacgaagag tttgatgtaa gaaccaagtg ggactcagat ggaacaccgg cacatactct 1514821 aagtgtaatc agtaagcaaa tgagattcga caactcagag gttccgattt taacgacaaa 1514881 aaaggttgcc tggaaaacag ccattaaaga gttgctctgg atttggcagc tgaaatctaa 1514941 tgatgttaat gatttaaaca tgatgggcgt ccatatttgg gatcagtgga aacaagaaga 1515001 cggaaccatc ggacatgcat atggatttca gctggggaag aaaaacagaa gtctaaatgg 1515061 agaaaaagtg gatcaggtag actatcttct tcatcaattg aagaacaatc catcttcacg 1515121 cagacacatt acaatgctgt ggaatcctga tgaattagac gcaatggcct taacgccatg 1515181 tgtatacgag acacaatggt acgttaaaca tgggaaactc caccttgagg taagagcacg 1515241 gagcaatgat atggcattgg gaaatccatt caatgtattc cagtataatg tgttgcagcg 1515301 catgattgct caagtgactg gttatgagct tggtgaatat atctttaaca ttggggattg 1515361 ccatgtgtac acacgtcata tagacaattt gaaaattcaa atggaaagag aacagtttga 1515421 agcacctgaa ctatggatca atcctgaagt gaaagatttt tatgacttta ccattgatga 1515481 tttcaagtta atcaactata aacatgggga caagctttta tttgaggtag cggtttaatg 1515541 ctgccttttt attgtgcagt gaatagatag caggtatcct aatttcatta agcaatctgg 1515601 aagatgaata aaaattgaag gacaaacacg tataatacat aaaaaagatt aactctacag 1515661 ttaatctttt ttattcagaa gaaaatatcc taactttgaa actaaataca aagtaaaagc 1515721 aatcattaca gttctagata ttacaattcc atgaatagct agatcatatc cagcaggtat 1515781 caacgcattt gtattacaca taaaatatat agatattaga agtgctacaa taactaaaat 1515841 cattccaaaa agacttgttt tttcatattt cataccaatt tccaccctta ttaaagttag 1515901 gtttaaacaa aagagctgaa gaaacgaact atgaccagta tgctccaagg aaaaccgcca 1515961 gacaatgctg gcggcttttt gctgcttcgt ttatttatta acagagatcg taacgttatt 1516021 tcctgcaact gaaacctttg cgaaatcctg tgtatctacc acaggagtga cggctttatt 1516081 gtcgatagtg atgttgttaa aagaggtcga aaaggttgct ttgatcgcat cacgctggct 1516141 ttcatacgaa acagccgcgg tagcaagtgt tttccatttt gaaatcgtgc cgatgttggt 1516201 tccttgaatt tctgtgataa tccgtccggt gtagccgtca ttgttcgttc cccaaagggt 1516261 catgcgcgta ttgccgctta aatttttata gattgtcatt tggactgtgc ttccagggcg 1516321 gaagccttta ttgtatgtga atttgtcttt tccttcgatg tacgtttctt catttttgga 1516381 cccaaccttc atgaggggct tccagacgtt gtattgtttg ctgtactgaa gcccgatatc 1516441 ggcttcagtt ccgcttgttg ccctaaagcc agaataaata tagggagtag agaccgagtc 1516501 gttgtttttg acagtttcag gaagcacgat tttagctgta aaaacggcgc ccgtactgtt 1516561 caggtagaca cggccgccga ttccgttagg cagctcggat gctgcttttg cgacttgagc 1516621 gtctgccgcg ggtaaacctg gtatacctga tgaaagggtt ccgaaaagaa ctgctgttcc 1516681 tactgcacct gcaatcaata cttttttcac caaaattccc ccttttgata gtggtttcgc 1516741 catttattat accttatttt ggaactggat ttacgtatat aaatcgacaa aatatttcat 1516801 tttgaatgat gtaaggtcga aacgcttcgc caatctgaaa gctatatacc tttatcagag 1516861 gaaagaatga gatcacattc gttttaaccg atttgaaatt ttcctcaaaa taaaagtaca 1516921 aatgcttaaa gaaacgatta ttaaaagaat gcccgctatc gtttccaagc ctgtaaaaaa 1516981 gaggtgacgt ttcatcaatg tctgtccttg taaaatgata aaagcacaga taccgactaa 1517041 gaaaagaaaa caaatactta ggattgctaa cgctttacgt gagtatgttt tcatttcatc 1517101 tttaaaatac agcaatacga aaataaagca gataacattg gctattgttc taatcacctc 1517161 aaagcttttc atgacaactg atataaatag acaaagtaaa atgagataaa atacgatgtt 1517221 tctatacaaa aaacctctcc ttttatgtag gatcctcaaa gagtttataa aagtttcttt 1517281 gtaactgcaa taaattgaat gcgctcactt atgaactaac taaactatgt actaaatatt 1517341 cactattctt tttcagattc agtcaccaag gttttcatag aaagggaagc ttcagaaata 1517401 tacatatagt gcacaaacaa aaaagacccg gcaatagccg ggggaaagta aaaacgagga 1517461 gatgttaatg gcgtttagta gtgtttttta tgctttttat actctacaac ataatcatag 1517521 tcttttttat cgtgatcata atatttttta tcatagtcat catatttttt gtcgtaatca 1517581 cagtcataat cttttttatc atattcgtaa tacttcttat aatacgtttt tttgaccgta 1517641 taatactctt ctttgtattt tttgtaataa cccatatata ctcctccttt atttttacta 1517701 cgctttatta tacggcgagt agattttgcg gcttggacag ttaaaatcat agaaggaaaa 1517761 aagggctgtc caaatgatag aaaaagacag atgacacaaa aacaaatcaa aataaagagc 1517821 cgatttttca tcggcccaaa cgatttatcc tacatttgtt tgtcttcttt gttttctgag 1517881 tcattttttc tgatatcctg agtcagtccg cttgttgctt gtttaaattc tgataaggct 1517941 tttcctgctg cacggccaag cgccggcagt ttatcaggcc caaatactaa aaaacccaca 1518001 aacaaaataa cgagtatttt tgtgaagctt aattccatat ccttttcccc ctgattgaag 1518061 tacaaccttt taaacaaatt ataagagata gcagtacaaa tgggaatgca tttattttga 1518121 acattttaaa accagcacaa agacggattc ataaaacggc tgctgctgaa tataatgtcc 1518181 aatgccacct gcctaagaag caggaggcag gctggatcaa ttatgtagct ctgccggaaa 1518241 tgatacaaac gtagcggcta tcattgacat agaggagtgg tgtagctgat gagattcact 1518301 aaggtagttg gatttttgtc tgttttaggg ttggctgcgg tttttccatt aacggcacaa 1518361 gcagaaaaag ccggaactgc gggggctgga gagtgggata agttggggac ttacacatat 1518421 acttactcaa gtccgacggt atactcgacc ggaggagatt ttagagtgtg cctttcagga 1518481 agcactcctt tttctgtttc actgcactta tatgaggatg atcccggtga caatcctgat 1518541 gattatgtag gggcaaacta tttttcaccc ggagaatgcc acacctttgg cagtattgga 1518601 aaatttgtag atgggagcaa taacaaggcc gagttctttg ttaccgatta ctctggtaaa 1518661 tctaaaactg ttacgtttta tgattgatgg actcaaattg tgaagtataa cccttggaaa 1518721 aaaacaaaaa agagagatac ctctctcttt tttattcttc gacagcctta cgaagccgtt 1518781 catttacaat gccagtccag ccgccatcca tcttaccgcg aacgacggag cttttctcgt 1518841 ttgctttgcc gatcacttca ttcggctctt tccagccgct gtgaataagg gtaaaccctg 1518901 tcttttcccc caagtcttct aattgaaagg taacgaccca tccttctgta tcccattcaa 1518961 aagaaagttc agttggagct tgaacagcca aaactttaca aggggacggc ccaaacggcg 1519021 attgtaagtg aaattcttgt ccttctttga gctgaaagtc attgggcata aaccacttgg 1519081 caatgccttc tgaagtagag actgtctccc agactttctg aatgggagcc tccagagtaa 1519141 tgctttttgt aatatccggt aatgcatttt cgttgttttg agccatttcg tttacctctt 1519201 gacatatgat gttttttcaa ttcaatcata taataactaa taagatcatg tccatagcgt 1519261 gcattattta tgctagagct gctgttgaac agcgtgtcag tcgccagtct gatctgtgaa 1519321 tgggagaatt ctgcatgcgc gaaaaagaga gagaggtgta tgttgtcatt tcgttcattc 1519381 ttgtttgcag ccgcaactgt tatgtttgaa ctgggattcc tgttcagcca atttattttg 1519441 cgatttttgt tttaatagta aatgagccat tttctaaaac aggaggtttt ttatgcttgg 1519501 aaaaatcaaa gcagccattg ataatagtcc agggaagccg gccagaattt tagttagtga 1519561 aaaagcgttt cagcaattag aggaagaaat gcgctttgtt tacgtttcca aaccgaaaac 1519621 gataatgggg attcctgtgg aagtttcaga tcaggcagaa agcttcaagc tggaatttta 1519681 gttttcccag actgctaaaa ggctcatttt gtgttaatta tgcaaaatgg tcaggttgat 1519741 ttctttaaaa gcatgatgaa atgttcatca tgctttttta ttgagaaaaa agacgaacat 1519801 aaaaaatagg tatacgggaa aaataatcct attagagaga ggggaactga cagatggata 1519861 acatgatatc aacacttact gactggaatg tgtggtttca agcgttagta gtatttctcg 1519921 ttccatatgt aatctataaa gtgtttactt ggattcatgt ataagaaggt gcaatgatga 1519981 ggtggcggaa caatcagtac aaaacacaga agcagcataa atcagattat tcgacagctg 1520041 aaaagcagga tcaggatgtg ttaaccggta acatcggata cgacttagaa catgtaaaaa 1520101 gaaaaatagg acataacggg gacgttcatt tccgtgagct tgaaatcact caattacatg 1520161 tgaaagcggc attgatcttt gttgaaggac tgtctgatca ggacttgatt aataaaggac 1520221 tatcagtgtt agtcatgaat caacctaatc aggtaagcga tgaaatttct caatccggca 1520281 aaggtatttt aacttcgaaa cagataaaaa atcaaatcgt atcaatcggt gatgtcatag 1520341 attcagagaa aatcagtgat atcgtgttga atgttttcat gggttcgaca gcgcttctca 1520401 tcgatggaat accgcaggcc tttcttctgg gaactgtaaa aaaacaaaat cgaagtatcg 1520461 aggagccgct ttcagaagcg cttgtcagag ggccgcgcac aggctttaca gaagagttga 1520521 gtacgaatac agctcttttg agacagcaag gaaaaaatga tcaattaaca ttgcagagat 1520581 ttgaagtagg aacacgatta aaaaaggatt taattatcgc ttatatgaat gacattgcag 1520641 atccaaaagt agtcgaggaa gtaagaaaaa gagtgagagg gattgagatc gatcatttgc 1520701 cggagtcagg ctacgttgaa cagttaattg aggataatta tttgagcccg ttcccgcaag 1520761 tacagagtac agaacgtcct gatcgcgtca taagcggatt aatggaagga agagtagcta 1520821 ttctgcttga cggcactccg tttgctttga ttgttccagt cactttcagc atgatgcttc 1520881 aatcgcctga agattattat gaacggtggt tcccgagctc gctcatcaga ttgctgaggt 1520941 tcatcgcagc aatgataacg ttattcgcac ccgctttata tatatcattt atttcttttc 1521001 atcctgggtt aattccgacc aagctggcga tttcaatttc cgggacgcgc caaggtgttc 1521061 cgttcccatc tctgattgaa gccttattta tggaagtcgc gattgaaatt ttaagagagg 1521121 cggggcttcg tttgccaaaa ccaattggac ccgcaatagg catagttggc ggattaatca 1521181 tcggggaagc agctgtgcag gcggggattg tcagtccaat catggtcatt gttgttgcgc 1521241 tcacagcaat ttcttcattt gccatcccgc attatagcac aggtatagca cttcggatgc 1521301 ttcggtttgg cgcgatgttt tgtgcggcgg tgtttggatt gtttggagtc attatgtatt 1521361 atctgctgct aagcagccat gtcgtaaagc taaagagctt tggtgtgcca tacgcaagtc 1521421 cggcagtgcc ctatcactta aaagattgga aagactttgt tatcagaatg cctcttttag 1521481 tcatgaagcg ccggcctaaa atgatgaata cagataatac aaaacgggtg aagtgatgaa 1521541 ctcgacagga tggtgataaa gtctcatgtt cagcccaacc agtaaaatca caaccgctca 1521601 ggcaacgatt atcatcatta attatatgct tgctgccgga gttcttacgc tccctcggac 1521661 agtaacagaa caaacacaat ctcctgatgg atggatttca gttttattag gcggggtcct 1521721 agcggtaata gccgggatga ttatagctaa attaagccag cagtatccta aggagacctt 1521781 ttatgaatac tcccgacata ttgtaggaaa atggctcggg catctgatca gtattgtttt 1521841 tattacttat tttctggcac tcggtgcatt tgaagtcaga gtcatgtccg aaatcgtgga 1521901 tttttttctc ctcgaaggga caccttcttg ggccatcatt atgacagttc tttggattgg 1521961 gctttattca attacacaag gcctagatcc gattgcacgg ctttttgaaa tgatttttcc 1522021 gattacggtc atcatctttt taacgatagc cctcatgagt ttaggcatat ttgagatcaa 1522081 caatttgcgc cctgtattag gtgatggaat catgccggtt cttagaggtg taaagacaac 1522141 gaacctttca tttacatgtt cagaaattat gttcatttta gtagcattta tgaaaaagcc 1522201 gaaaaatgcg gtgaaagcag ttgtgatcgg gacaggcgtt gtgaccagtt tttatatgat 1522261 tacgatgatt atggtcatcg gtgcactatc agttgaggga gttgtgacga gaacatggcc 1522321 ggggcttgac ctgatgagaa gttttgaaat acctggttta atatttgaac ggtttgaatc 1522381 atttctgctt gtgatttgga ttatgcagct ttttgccacg tttattatca ctttttatgc 1522441 agcttccctg ggagtctcac aagtttttaa aaagaaaccc ctttcatgta tgtttgggct 1522501 gcttcctgtt atatatatcc tctcttgcat gccgaaaaat gaaaatgacg tctttatatt 1522561 gggcgatacg gtcagtcata tcgctttgta tatatttggc gctttgccga ttttgctgtt 1522621 agtcatttcg aaatggagga aaagaggtga aaagtaaact aaaacgtcaa ttgcctgcta 1522681 tggtcatagt atgtctgctg atgatttgcg taacaggatg ctggagcagt cgggaaatag 1522741 aagatctggg tctcacattc gctatcgcaa ttgataaagg aaaagaaacg aacactgaaa 1522801 aagagttaaa agaagagggc gggagctatc cgaaaaaaga caacattacg ctgacctatc 1522861 aatttgttaa tgaaaaagcg gcaggcgcgg gcacaagcgg gggaggcggt agcggacaag 1522921 gagcgcaaaa agcgtacatt aatataagtg aaacagggga ttcattacag cagatcggaa 1522981 gtgaggttgc attaagacgg gaccgagaag tgtttagccc gcatttaaaa gttgttgtca 1523041 tgagtgaaga tgtgctgcac acatttccta tcgacgaaat gctggatcaa ttttttcgtg 1523101 ataatgaaat caggctgagc tgtcttgttt tatctgctaa aggggaagca agagacgctc 1523161 tccagctgaa agagaacgga gaaattccgg catttcggct gattggatta ggtgaaaatg 1523221 aacataaagt ttccagaatt cttcccccta tgacactcgc gaaactaatt ggaaaactgc 1523281 attctggcag cagcttttta ctgcaaaatg tggttgcggc gaatggagcg gtcaagtatt 1523341 ccggagcagc tgtaatcaac ggaaaatcga aaaaaatgat aggcacctta aatgaatatg 1523401 aaactgaggg gattacatgg attagaggag aagggaaagg cggagttgtc aaaagtcatg 1523461 ataaaaagag ccaacagacg ttagcgtacg atatcaataa aatcaaaagc agaattcagc 1523521 caatcgtaaa agggaaagat atttcattcc atgtcgatat tgaatcagaa ggcgatttgg 1523581 ttgaaaactg gaacacaaaa gaggcgttgg acacccagtt tatagatcgt ctcgaaacga 1523641 ctattgaaaa cgaggtaaag aaaatagttg gtcaggtatt aaaaaaaatt cagcatgatt 1523701 ataaagcaga tgttgcgggt tttgatgaat cttttagact tacatatcct cacttatgga 1523761 aaagggtgaa aaataactgg gatgacacct tcagtaaagc cgacatcaca tacagtgtga 1523821 acgtcacaat tactcatttc ggcacggtta aaactcagta atgaatccca aggaagagaa 1523881 ggaaacctct cttctctttt ttatgcattt attaggataa agatactttt tttggagaga 1523941 tatacacttt tcaaatcgac caatatgcta atataggaat tgcttgaaat agaagggaga 1524001 aggggctgtg aggcagaaac cgatttatgt agaaatcgaa atgaaatctg atctggatac 1524061 actctgggaa tatacacaaa acccatcact gcataaggaa tgggatctcc ggttttcaaa 1524121 tattacgtat ttgaatagtc agccatgcga aaaacagaag tttctttacg aaacaagggt 1524181 aggctttgga ttaaaggtgt caggtacagg agaaaccgtc ggtgttttca acaaatgttc 1524241 atctgaaagg tcttcttcac tggcttttgg ctctgatcat ccattatctc tgattcggca 1524301 tggaagcggc tactggaagt atatacagag agaaaatggg aaaatgacgt ttttaacaca 1524361 gtaccaatac aaaacagcct acggactgct gggaagatgg attgatcgtt tattatttcg 1524421 gccgctgctt ggctgggcga ctgcctggag ctttgatgca ttaaggcttt gggtagagca 1524481 aaataaacat ccgaagcgct tcattcgatc tgctatcatc tatgtgttca tgtgtctgtt 1524541 tttcagcctg ttttggttct atcaaggctt tgcaggtgtt aagacaagca tattgacagg 1524601 aacagcggag ataggcttag ctattttgtg gctgcttcct ttaaaaagaa aatggatcat 1524661 tcatggtgtc caggcttgta tttttgctgg gtttgcttgt ctaggttccg aaatattcat 1524721 gtgggttcta ttgagtgtgt tttccgctgc aagcggcgct cttagcctgc agctccccag 1524781 tgccaggcgc acaaaacgaa agagaaagaa gtgacattgt gagttcgatt tatgaaaaat 1524841 caattattaa ctatcatttg ctgcatccca agctgcagaa acggtaccaa ttagacgggt 1524901 ctcatacatt cagcgggacg ggaacgatgt cagaaataag cggaggctct tttctggtta 1524961 gaatgctgtt aaagctgggt gtttttttca gatgcttctt ttcagaaaga ggcaaagaca 1525021 ttccatttac aatacaaaat agaacttgtc ttttgaaatc gcaacataca ggaatagaat 1525081 ggaatcgtac atttttcttt aaaggcaaaa aacgtttctt tgatgcgtta atgatatatg 1525141 acgagaaaga aaatagaata cttgatttct tcggcaaacc tcatctgctg ctgtctgttt 1525201 tgacgttcga ggcatctctt gacggctctc ttacgatcac atcgggaaag caatggctat 1525261 tgatatgcgg aaaaagaatc ccgctgccga aatggctgac cggtacatcc gaagtttgcg 1525321 aaacgtttga tgaaaaaaag aattgtttca ccattgaagt gcatgtgcaa aatacaattc 1525381 ttggcactct tttcttttat aagggaacgt ttcaggagga agagagagaa tcatgaaacg 1525441 aaatggcata gtcagtgcgc tttgttttat tggatttctt gcagcagaag caccggatat 1525501 ttcagtggca gaggcactcg ttttgttatc cattctattt ttcgtgccgg gaatttttcc 1525561 ttttgttttt cgtcaatctc cggttcgtgc tgctcagttt atggaaaacg ggctaatcca 1525621 gtgctatcct gtagccgcat tctttgcggt gctggctcta gtgacggagg ttgggggttt 1525681 cgcacttatc tggtggatgt acacagtttt taatgcattg tatgcgatcc tccgcctttg 1525741 ggaaacaaag atacatagaa tcgaagagac atcagttttg ttcggtctta tttatttggc 1525801 gggaggagga ttttggtttt ttgcttatgc tgcccatttg cagatcatgc aatttggccc 1525861 tctcatcatt ttgctgactg ctgtccactt tcactattct gcttttctga tcccgatctt 1525921 caacggttta ctcggcagaa ccattagaaa acatcggatg ttgtacagtt ggataacatg 1525981 ggtgattttg ctttcgcccc ttcttatcgc actgggcatc acatattcaa aaacacttga 1526041 tgtcattgcg gttagcattt atatggcggc gatttatctt catgcatttt tggtgttcac 1526101 ggcagctttt cgcaccaaga cggggacatt tcttattcgg ctttcttccg ctgttttaat 1526161 gataacgatt gctttctcga tgatttattc atttggtgtc tttcggcaag aagttacatt 1526221 gaccatcaat cagatgattt ggattcacgg ttttgtcaac gcgtttggtg ttatcttgcc 1526281 cgctctcata gggtggagaa tagaggatgc gaaacctttt gatgcagaca gtgtaaagac 1526341 attcagccgt atctacggaa aaagaaagat tggagaagaa tttttagcta acattcaagc 1526401 tgaaaataac gctcggtaca gcggacttgt ggatgatatg ggcagcctgc gttcaaaaga 1526461 tttttcacca gaaaaactgg cgccgctcat tctttcgttt tatgaacaaa ccatcgaata 1526521 caatattaaa gcaaaagtaa catggagcac gtggtttcgg ccgcttgcaa ttatttacga 1526581 atggttcagc agaagaatcg gccaaataca tctttcgacg aaccctgact ggtataggat 1526641 gtacagcaag ataaaaggtg ttcattcgaa aaaagacgga agggaaagag tacgtgcctg 1526701 gattagaaca aatgaaaaaa acgaaaccat ttttaccgct ctttattcag tgtatcgttc 1526761 aaatggagag gggtatatga atatttcttt accgcttcca ttcagcagca tgacaggtat 1526821 tttaaaacca tatcatcatc aggagaagct ggttttaaca agcaggcgga gaaaaagcag 1526881 agcgggggat gaggggattt atctgcaaac aagagcggga acttgtccgc ttcctttatc 1526941 tgaaaccttt ctgatagaag ctgtacatga caacaaatta accgctgttc atcatatgtg 1527001 gctgtttgga ataaaatttc taactgttca ttacagcatt acacatatta accagcctat 1527061 tgaaagaacc taacacaaag aagaagcttc gtctgccagt tgtaatgaga tgaactgttt 1527121 taaaattctg caccgcatca agacaggaaa ggaagggttt atggtgtttt atatcagttt 1527181 atttctgatt ctttggctgg ctgctgggtt tgcagtggga atgaaacaag tgtatgtcga 1527241 tcagctgttt gataaagctg tgatcgaaag actggaaaaa gaagcgaatg atcatggaca 1527301 tgctgaccgg atgatcaaac agcgcgtcct ttatattgca gcagtgacag taagcgggtt 1527361 tatttctgtt tattatgaaa tgaaaacaat cccgcaaagg cgaaacataa gaaaaattga 1527421 aaaaaacatc atgaaattaa atcaagcaaa aaaacgaaga atgaagagaa aataaaaagt 1527481 gcacaggcca aagggcaggt gcatttttgt tttgtatgga aaatggggga ggtggtgcca 1527541 gcttactttt cataaattca aaaatgagaa gaacagcgcc cgggctaatg gtatataata 1527601 ttgtgaattt aacaaaaatt taacaaggag gacgagagaa ttcgtgctaa agcctcaaag 1527661 agacctacat tctgttgatt tggacttaga ggcggagtag atgaaaccgg ccaaagtatc 1527721 cctgctccgc cgtttgctcc attccttgaa gcatgttgat tgtaacatag ccaaacgttt 1527781 tccatcaact attaaaattg taaaattatt gatgattttt atggtgttta ctccgatttc 1527841 ttcaatttat gctgaagatg tatatcagaa ttttgaggaa ttaaaaaaca atgaagatcc 1527901 ttctgattat ggcgttgtta cgaaagaaac cggaagccct gttcttgttt tagctattca 1527961 cggaggaggt attgaaggcg ggacaagtga agtagcgaga gagctcagca aagagtactc 1528021 gatgtattta tttgaaggct taaaatcggc aggaaactca gtcctgcaca ttacgagcac 1528081 acactttgat gaacctcggg cccttaaaat gacgggaaat catgaatatg tcatttcatt 1528141 acacgggtac gcagaagaag atcagcagat cgaagtcggc ggtacagatc gcgtaagagc 1528201 ggcagattta gttgagaaat tgcagcatgc cggttttcct gctgtattgc tcaatatgga 1528261 ccatccgcat gcgggcgtta gtccgaataa cattgcaaat aaatcaaaaa caggtttaag 1528321 tattcagata gaaatgagca cagggtttcg aaagtctttg ttcggcatct tttctttaaa 1528381 aagcagagct gttactcaaa atgagaggtt ttatgagttt acagaagtga tgttccgttt 1528441 tctcaaaaat agctactgaa aaataggagg cgataagaca gcctcctatt ccttatgctt 1528501 ctctttcgtt tcgggaaaca gctcgtccgc ggcttccgtt tgatactgca acgtgttatc 1528561 tctcgctgac agttcatttc ggaaattttc atcaagcaca tttttcagta aataccgatg 1528621 aaaaaagtat tcaaaaacag taagacaggc agcggaaagg agagccgctc caaatggtga 1528681 gaaatcgttt cttgtttggg ttaaaacaaa tacccaaaga ataacgaatg aaaggccaaa 1528741 gtcagccaat gaagctgtaa tattgtttgt tctgggtaag acgagcatgt caccagaaag 1528801 ataggaaaca aaacctaaga aaagtgcaat aaacatcaca cttaaaaagg atgcgtgata 1528861 gactctgtcc aaaatcacat ataaaagggc gagagtgaaa gcaatctttg aagcaagcgc 1528921 aatgatatgt ttcatttgac cacctaaatt gttatttttt gaagaaaatt cttgggcgta 1528981 aacaaatgat aaataatgca attcaaaacc attcataatg gtcatgttac tattttaaac 1529041 agtccgtttt tgtttacact ggtatttttt tcagctgtat gaaactttct tatgaaaaaa 1529101 gtcgtatatg tggatgatca gctttcaagg ggggaatgat ttgtggagat aaaaggaatc 1529161 aatcacttgc tattttcagt ttcgcatttg gatacatcga ttgattttta tcaaaaagtg 1529221 tttggtgcaa agcttttggt aaagggaaga acaactgcat attttgatat gaacggcatc 1529281 tggctagcgc ttaatgaaga accagacatc ccgagaaatg acattaagct ttcttatacc 1529341 catattgctt ttacaattga agatcatgaa tttgaggaga tgtcagctaa attaaaaaga 1529401 cttcatgtca atattctgcc tggcagagaa cgagatgaac gcgatcgaaa atcaatttat 1529461 tttaccgacc ctgacggcca caaatttgaa tttcataccg gaacccttca agacaggctt 1529521 cgatattaca aacaagaaaa aacgcatatg cacttttatg atgaaacggc cttttgatag 1529581 cacaaccata tttcatataa ggttaaattt aaagaagggt gttggtggag actttatgtt 1529641 tggggaaggt ttctacccga cttgttcaac gatgccatat cttttgaact gcacaagtga 1529701 ttgggtgaag gtgaaattga aatacacatt acattacatt ttatatgaag aaagcgagct 1529761 gttttatcaa atgttgaact aattaaacta tgtactaaat tttcagtata tttcaattgc 1529821 tttgcccctt aataaatata aaaccgcatc cttccacgac ctaaaaaatg aaacgttttt 1529881 aagaagatgg cgtctaatat tctaaatgtt catattttga taaaagtttc ctaaaggaaa 1529941 gaaaatttct tgacttcaac aatcttttgg tggataatta tggtgtaaac atgatgttct 1530001 ttttcctcct attcgggctc gcacccaaaa gtcagggcga gcctgctttt tttgaacaac 1530061 aaaccccctc tccgtaaagg aagagggggt tattttatgc atctgataga tcaatagatt 1530121 aatggacggt tctgaacacg ccaatcactt tccctagaat gctgacattc tgcaaaatga 1530181 taggttccat cgttgggttc tcaggctgca agcgaatgtg ggtatcctct ttatagaatc 1530241 gttttacagt tgcttcatca tcttctgtca tcgcaactac aatttcccca ttgttcgctg 1530301 tgttttgctg tttaacgatg acatagtcct tatcgagaat accagcatct atcatactgt 1530361 ctcccataat ctccagcata aatacatgct cgtctggagg aaccatgcgg tcagggagcg 1530421 gaaaatattc ttcaatattt tctactgctg taataggaga tcccgccgtg actttcccga 1530481 tgaccggtac attaacgacc tggctttgcg gaatgtctac ttcttcatca agaatttcta 1530541 ttgctcttgg ttttgtcgga tctcgtctga tcagcccttt tgtttccaaa cgggccaaat 1530601 ggccgtggac agtagaactg gacgcaagcc cgacagcctc tccgatctct ctcacggaag 1530661 gcggatatcc ttttgattta acctctgctt taataaaacg gaggatatca agttgccttt 1530721 ttgatagctt cgtcattttt cgcacctcaa aacgtcgatt ttaagaagat tatagcatga 1530781 ttttccttac agtacaaaca taggttcgaa aaaacaattg acagaaacgt ttgttcgtat 1530841 atactgaaat tataaaaatg cgaacaaaca ttcctgttgg aggttatgat catgagtaaa 1530901 gaatctatta tttttgtcgg tctgtttaca gtgattttga gcgcggttat ccttatgctg 1530961 tcatatacaa gcagcggcca agagcttaat cagtatgtta aaatagaagt ccagcaaggc 1531021 gacacactct ggtcaattgc tgatcaggta gccgatacaa aaaagataaa caaaaatgat 1531081 tttattgaat gggtagctga taaaaatcaa cttcaaacct ctgatatcca gccgggtgat 1531141 gagttagtga tcccattgaa aaagaagcat caggatgcat atgaattagc aactgtaaga 1531201 tagagaggaa agagagataa aatgaaagca ctcatttatg cccgtgtaag cacaaataaa 1531261 gaacagcagg aaacgtcatt aaagcggcag gaggaggagc ttacggccat tgcagcggag 1531321 aacggcatgg aagtggtcaa agtgatttca gaaaaagcca gcggatatga aatggatcgg 1531381 gatggtgtat ttgagctgct cgatgagatt aagaacgctg atattgatgt cattttggtt 1531441 caggatgaga caaggctcgg acggggaaac gcaaaaatcg cactgcttca ttgtatttat 1531501 agagaaggtg tgaaagtcta tacaacggct catagaggtg aactggagtt atcggaggct 1531561 gactcaatgg tcttggaaat cgtcagcatt gtggaagagt atcagcgaaa gattcacaac 1531621 atgaaaatca gacggggaat gaaacgtgca gtaaaaaacg gttttaaacc gcaaaaaaac 1531681 ttaaaaaacc aacatgggaa cagtggaaaa gaaaaaatag aggtgccaat ctcagagatc 1531741 gtccgcctga gagcgaataa actgacgttt gctgaaatcg cggctaccct aagagggttt 1531801 ggctatgatg tctctaaagc aaccgttcac cggcgttttc aggaatacat agagaatgaa 1531861 gagactgcag agtgaatcag ttgtaaaact ttttttgatc tagtactata tagacaaaat 1531921 gcaataaagg agtttaacat gatttcaaac gcgaaaattg ccagaattaa tgaacttgct 1531981 gccaaagcta aagctggcgt tattacagaa gaagaaaaag ccgaacagca aaagctccgt 1532041 caagagtact tgaaaggttt tcgttcttct atgaagaaca cgttaaaaag tgtgaaaatc 1532101 attgacccag aaggcaatga tgttacacca gaaaagctaa aaagagaaca aagaaataac 1532161 aaacttcact aatataagag gaatacggca atatcgtatt cctcttttgc atatactata 1532221 atcaaaactc ttatgtgaca aaattcaaca agtttctctc aaatttaagc tgaaacagtt 1532281 gagaaaaagt cgtcagacat ttatgatgta agggtacaac acataaggaa ggggattttt 1532341 atggatacaa ttgaaaagaa atcagttgct accattcgca cactgtcaat agacgctatt 1532401 gaaaaagcaa attctggtca cccagggatg ccgatgggag ccgctccaat ggcatacacg 1532461 ctgtggacaa aatttatgaa cgtaagtccg gcaaaccctg gctggtttaa ccgtgaccgt 1532521 tttgttttat ctgctggaca cgggtcagca ctattataca gcatgcttca tttaagcggg 1532581 tttgatctta gtattgaaga tcttaaggga ttccgccagt ggggcagcaa aacaccagga 1532641 catccggaat tcggacatac tgccggtgtt gatgctacaa caggtccgct tggccaagga 1532701 attgccatgg cagtcggtat ggcaattgct gaacgccatt tagcggaaac atacaaccgc 1532761 gattcattta acgtagtcga tcattataca tacagtattt gcggtgatgg tgatttaatg 1532821 gaaggtattt cttctgaagc cgcttcactc gcaggccatc ttcagcttgg ccgtctgatc 1532881 gtactatacg attctaatga catctctctt gatggagacc tcgaccgttc attctctgaa 1532941 aacgtgaaac agcgttttga agcaatgaat tgggaagttc tttatgttga ggatggaaac 1533001 aatattgaag aattaacagc ggctatcgaa aaagcacgcc aaaatgaaaa gaaacctaca 1533061 ttaattgaag tgaaaacgac aatcggattc ggttcaccta accgtgccgg tacatccggt 1533121 gttcacggtg cgccgcttgg taaagaagaa agcaaattaa caaaagaagc ttacgcgtgg 1533181 acatatgaag aagacttcta cgttccgtca gaagtttatg agcatttcgc tgtagctgtt 1533241 aaagaatcag gtgagaaaaa agaacaagaa tggaatgctc aattcgctaa atataaagaa 1533301 gtttatcctg aacttgctga acagcttgaa ctggcaatca aaggagagct tccgaaggac 1533361 tgggatcaag aggttcctgt gtatgaaaaa ggaagcagtt tggcatcccg tgcatcttcc 1533421 ggtgaagttc tcaacggact tgcgaaaaaa attcctttct ttgtcggagg ttctgctgac 1533481 ctagcgggat cgaacaaaac gactattaaa aatgccggtg attttacagc ggttgattac 1533541 tcaggcaaaa acttctggtt tggtgtacgt gaatttgcga tgggtgcggc cttaaacggt 1533601 atggcgcttc atggcggtct tcgtgtattc ggcggaactt tctttgtctt ctctgattac 1533661 ctgcgtcctg cgattcgcct tgcagcgtta atgggccttc ctgtgacata tgtcttcaca 1533721 catgacagta ttgcggttgg tgaagacggt ccgacgcacg agcctgttga acagcttgct 1533781 tcactccgtg cgatgcctaa cctttctttg atccgtccag cagacggcaa tgagacagca 1533841 gcagcatgga agcttgcagt gcaaagcact gaccacccaa cagcgctagt gcttacacgt 1533901 caaaaccttc ctaccatcga tcaaacatct gaagaagcat tggcaggagt agaaaaaggt 1533961 gcatatgtcg tttctaaatc taaaaacgaa acacctgacg ctcttctcat cgcttccgga 1534021 tcagaggtag gtcttgcaat tgaagcgcag gctgaattgg caaaagaaaa tatcgatgtt 1534081 tctgttgtca gcatgccttc aatggaccgt tttgagaaac aatctgatga atacaaaaac 1534141 gaagtccttc ctgcagatgt gaaaaaacgt cttgcaattg aaatgggctc atcatttgga 1534201 tggggcaaat acacggggct tgaaggtgac gttctcggca tagaccgatt cggtgcatct 1534261 gctcctggtg aaaccatcat taacgaatac ggcttctcag ttccgaacgt agtgaatcga 1534321 gttaaggcat taatcaataa gtaagctttt gaaagaggat gagtcaaatc atcctctttt 1534381 tcttgtttat ccgacaaaaa tagtattggc tgtttaacag taatagacaa ttctttcttt 1534441 tcttcttttg tataatagag agcaaatgaa atgctgctgg aaaaggggat gaaaagatgg 1534501 aacgtcacta ctatacgtac ctgatcaaag aggaatttgc caatcactat ttcggccggg 1534561 aatcggttat gtttgagctg tttcaagact atcattggac aagccttgaa aagcagcagt 1534621 atgaaatgac agagaaacag attcaatata ttacacaacc aatcccgatt ttacatatgc 1534681 atcagcggtt aaaaatgaat ttaaacaaga cggattacag gcagctggat tatatttata 1534741 gaatagcttt gccgaaagca aaaggccacg cgacgtttat gatgaaggag cacatgatag 1534801 aaattgtggc ttcgggagat tacgaggcag aaacgatatt ctttgaagtg ttaagaaaag 1534861 taagcccttg ctttttagca atggatttca attcgaagcg ttacggatgg ctaaatccgg 1534921 tgaaagaaag aaattttgtc taaaaccgaa gaaaaagaga tgtaaatgtt gtataatagc 1534981 ttttggttta gtacacttta aactagacaa catgaaggag gaaataaaat gactttatgg 1535041 gttggcatcc tagtgggcgt tgttgcattg ctcataggtg ttgcactcgg gttttttatt 1535101 gctcgtaaat atatgatgag ctacctgaaa aagaatccgc ctattaatga acaaatgtta 1535161 cgcatgatga tgatgcaaat gggaatgaaa ccttctcaaa agaaaatcaa tcaaatgatg 1535221 aaagccatga ataatcaaac gaaataatac gtaaagatta tgatatagag aaacatggtt 1535281 ataaaataaa aaacccttat acgggttttt tattttgcaa tcattcatca cccgctactg 1535341 ctcgaaggcg ctgcttttga tattgtatga gaagatggtc aagctcctga ctgagctcta 1535401 tcgtaatatg agatgtcatt ccgttcgcca tgacaatttg cagcagctct gctctttttt 1535461 tttcaatttc ttttaataga tgctctctaa tcacagggat gtatcctttc atacattaga 1535521 tcttcaaagt gaatgtttat attatatcca tatttatact aattttcaaa tgagaaggag 1535581 tataatgtct caatgtcaaa ttaaattata taagtttttt ctgaaaatag aaatccttca 1535641 agtgaaagtg ttaaaaaaat gaaatgattt tgtcataact tgaaggaatg tcaaatcatg 1535701 aagggatgat gacatgggag acgtgaatta ttttttgaca ttcggagcgg ggtttttatc 1535761 ctttatttcg ccttgctgcc tgccgcttta cccagctttt ttgtcatata ttacaggggt 1535821 cagcatggac gatgtaaaaa ctgaaaagct gctgctgcag aaaagaagct tgtttcatac 1535881 tttgtgtttt ttgcttggct tttcagtcat ttttattgct ttaggctatg gaacatcttt 1535941 tattggcagc ctgtttaggg attatcacga tgcgattcgg caaattggcg cgttgcttat 1536001 tattttgttc ggtttcatta cactcggtgt gttccggcct gaggctatga tgaaagagcg 1536061 gagaatccat tttaagcata aaccaagcgg gtttttaggg tcggtcttaa tcggaatggc 1536121 atttgcagct ggatggacac catgtaccgg tccgatatta gctgctgtta tcacacttgc 1536181 aggcaccaat ccgggctcag cggtgccata catgatgtta tatgtactcg gttttgcggt 1536241 accgtttctt ttattgtctt tttttatcac aaagctgaag tggataagga agaaccagct 1536301 tttcattatg aaagctggtg gcgttttgat gattgtgatt ggtgtgctgt tattctttaa 1536361 ttggatgagc ctgatcatta ttttgctgtc agatcttttt ggaggcttta ctggtttttg 1536421 acggtaaatt actttcgtac tactactaat ccttttgttt ttggtacaat aagactatta 1536481 tctgtggaaa tcgattgttg gaggggaata tgacaagagt tttagttgta gacgacgcca 1536541 agttcatgag agtgaaaatc agagagatct tggaagaggc aaattacata atcgcaggcg 1536601 aagcggcgga cggtgaacaa gcagctgacc tgtataaaaa actgcgcccg gaccttgtga 1536661 caatggatat tacaatgccg gtgaaaaacg gcataaaagc gcttcgtgat atcttaacct 1536721 ttgatcctaa agcgaaggtc atcatgtgca ccgccatgcg ccagcaaaga attgtaacgg 1536781 aagcaattga gctgggggca aaggatttta ttgttaagcc gtttgaggaa acaaaagtgc 1536841 tggaagctgt aagccgcgtt atgggacatt aaagtcattt cttttcaaaa tggttttttt 1536901 tattgttttg gagtatagta tatagtatca acactccgag aaacaaagga atgataagta 1536961 tgatgattat agtttcatca attattgctg tgttaatggc tgtagctgtg atggtggtca 1537021 gaataaagtc ctctgacaag cctgtttcac caaaaaaaat cattcttccg ccgattttta 1537081 tgagtacggg agcgttaatg tttttatttc cggtattttg ggtaactgga gcagagtttt 1537141 tggaagcatt cactttaggt gtgattttct ctatttttct aatcaaaact tctaagttcg 1537201 aaattaaaaa taatgaaatt tacatgaaac gctctaaagc atttgttttt atattagtcg 1537261 gtcttttggt gatcagaatc gtgatgaaat cgatcttgag cacatcaatt gattatggtg 1537321 cactgagcgg aatgttttgg attctggctt tcggtatgat tgtgccttgg agaatcgcca 1537381 tgtatttatc atatcgaaaa cttcataacg agctgcagtc atctaatatt caaatgaatt 1537441 aaaaaacctt tcctcttgtc aggaaaggtt ttttatttga gaagggtctg ataaggttcc 1537501 aaatcgattt ttttgtcccg cagatgcctt tttaagaagg tatggtctct tttaggagtt 1537561 gcgagaatat agcctttgat cataagttgc tgatcaatct ttgctacctt ttcttttaat 1537621 gcaagctcac cgattttgcc tgcgatttta gcttttgctg catctctgaa cagctctggc 1537681 acgggcgcag tcaattcatc tagaaactgt ttgttttcat cgttccataa atgtctgctg 1537741 ttttcaatat agtaatcctg ccaatcaagc tctgatctgc cgtcctcttt tggtaaacgc 1537801 tttaaaaact ttcgaaacat gaaaaaaccg ccgattgata ataagactac catcatgatt 1537861 acccaaaaca gaataaacca taaaaaccat ccttccagca tcaatcattc ccccttattc 1537921 taaccatatt gtatacgaag agagattaga agaacacagt aaaaaaagaa tagaaaaaag 1537981 tgatagacgt ctagtcaaaa gagatagtag atcatattct attgtatagt gaatctgcta 1538041 tttggccatg ggagagtcac tagagggtat ttgacgataa atggacggaa aaaaagtcac 1538101 tttcataata ggggatgaaa gtgacttttt atgtttagct gagaggaaat tgaagagaaa 1538161 aagaagagcc atcttctgtt tctttattga cggcgactgt gagtatttga ttttcgcatt 1538221 cgacttgaat gtttttgtca ttaaaataaa aaggaagcat catttgtttt tcaaaagtct 1538281 gtcctgacga tttgacagtt aagatgaact cgcatccaga aagggtaact gttacttgtg 1538341 taggctgtaa aaaagtcaga tccgcttcta taatatactg ctgacttgtt tcatataaat 1538401 caataggcaa tgtttcgtcg taccaggcga aggggtcttc aaaaaattgc cgaagccatt 1538461 catccatact atcgaaatca ttcgcatcgt tgcgttttga atggttcatg gaagcattcc 1538521 tccacatatc aaccttgctt tacatcatat gcggtggatt ataaatgggt gaacgcataa 1538581 aaaaacagac actaaggtct gcttttctta catatcatgg cttgagttgt gcttttgtct 1538641 tgtatggttt cggtttttta cttttttgct tccgcttaga ggctcgggtt ggccgggatt 1538701 gtgtccttta ggggcgtttt tatgcatatc tttacttgta ttcttattgg tcataaaatg 1538761 agaacctcct taaaagagtt cggtgttatt gattggtttt tctttttttg ttattttggc 1538821 gttctgcttc agtcagtaca agctggtcgt tttcaatata gccggcgcct ttgccttggc 1538881 tttttgcgtc attcattccg ttaatgacgt gattcgcttt tcttttgacc atcattatca 1538941 cctcaatcat aatatggctt cttttattgt gttatatgag agagcgtaaa cagtaaaaat 1539001 taccggtaca tttttctcat aagtcgaact tattgtattt aataaaaaca ttgatattta 1539061 cttatgtatg attttgtttt aatatgaaat tgtgagaaaa ttgtgatgga atgtaatgtt 1539121 catctgagaa tgatctgatc tgaaggggga ttttggagaa tggcaaacga gcaaaaaact 1539181 gcagcaaaag acgttttcca agcgagaaaa acgtttacta caaatgggaa aacatatcat 1539241 tactactctt taaaagcgtt agaagattca ggtataggaa aggtttcgaa gcttccttat 1539301 tccatcaaag ttcttttaga atcagtattg cgtcaagttg acggcttcgt tatcaaaaaa 1539361 gaacacgtgg aaaatttggc aaaatgggga actgccgaat taaaggatat cgacgttccg 1539421 ttcaaaccgt ctcgtgttat tttacaagac ttcacagggg ttccggcagt agtagatctg 1539481 gcttcactgc gtaaagcaat ggcagctgtc ggcggagatc ctgataaaat caaccctgaa 1539541 attcctgttg atctcgttat cgatcactct gtacaggtag ataaagcggg tacagaagat 1539601 gcattagcag taaatatgga cttggaattc gaaagaaatg cagagcgcta caaattttta 1539661 agctgggcaa agaaagcgtt taacaattat caggcagtac cgcctgcaac aggtattgtg 1539721 caccaggtca accttgagtt cttggcaagt gttgtccatg ccattgaaga agacggcgag 1539781 cttgtaacgt atcctgatac gcttgtcgga acagactcac acacaacaat gattaacggt 1539841 atcggtgttc tcggctgggg tgtcggtgga attgaagctg aagcgggaat gcttggacag 1539901 ccttcttact tcccagttcc agaggtaatc ggcgcgaaac ttgtcggcaa gcttccaaac 1539961 ggaacaacag ctactgactt ggcgttaaaa gtaacacaag tgctgcgtga aaaaggcgtt 1540021 gtcggtaaat ttgttgaatt cttcggaccg ggaattgctg aactgccgct tgcagatcgc 1540081 gcaacaattg cgaatatggc tccggaatac ggtgctacat gcggattctt cccagtagat 1540141 gaagaagcgc ttaactacct gcgcctgact ggccgtgatc ctgaacatat tgatgttgtt 1540201 gaagcatact gcagaagcaa tggcttgttc tacactccag atgcggaaga ccctcaattt 1540261 actgatgtgg ttgaaattga cctgtctcaa attgaagcaa acttatcggg tccaaagcgt 1540321 cctcaggatt tgatcccgct atctgctatg caggaaacgt ttaaaaagca attagtcagc 1540381 cctgcaggta accaaggatt cggtttaaat gctgaggaag aaaataaaga aattaagttt 1540441 aaactcctta acggcgaaga aacagttatg aaaacgggtg cgatcgccat tgctgcgatt 1540501 acaagctgta caaatacatc aaacccatac gtgctgatcg gcgccggact ggtagcgaaa 1540561 aaagcggttg agttagggct taaggtgcct aattacgtga aaacgtcact tgcaccgggt 1540621 tctaaagttg ttacaggata tcttgtgaat tcaggccttc ttccatacat gaaagagctt 1540681 ggctttaacc tcgttgggta cggctgtaca acatgtatcg ggaactcagg tccgctttca 1540741 ccggaaatcg aagaagcggt tgcgaaaaat gatcttctga ttacgtctgt cctttccgga 1540801 aaccgtaact ttgaaggacg tattcacccg cttgttaaag gcaactatct tgcttcaccg 1540861 ccgcttgttg tggcatatgc gctggctgga acggtaaaca ttaacttaaa aaccgatcca 1540921 atcggtgtgg gcaaggatgg tcaaaacgta tactttaatg atatttggcc gtcaatggac 1540981 gaaatcaatg cacttgttaa gcaaactgtt acgccagagc tattccgcaa agagtatgaa 1541041 acagtatttg atgacaacaa gcgctggaac gaaattgaaa caacagatga agctttatat 1541101 aaatgggata acgattcaac ttacatccaa aacccaccat tctttgaaga gatgtctgtt 1541161 gagccaggca aggttgagcc attaaaagga ctgcgtgttg tcggtaaatt cggcgattca 1541221 gtcacaactg accatatttc tcctgcgggg gcaatcggaa aagatacgcc tgccggaaag 1541281 tatttgcaag aaaaaggtgt ttcacctcgt gactttaact cctacggctc ccgccgtgga 1541341 aaccatgaag tcatgatgag aggaacattt gccaacattc gcatcaaaaa ccaaatcgca 1541401 ccgggtacag aaggcggatt tacgacgtac tggccgactg gtgaagtaac atccatctat 1541461 gatgcatgca tgaaatacaa agaagataaa accggtcttg tcgtattagc aggaaaagac 1541521 tatggtatgg gatcttcacg tgactgggct gcaaaaggaa caaaccttct cggcatcaga 1541581 acggtcattg cagagagctt cgaaagaatt cacagaagca atcttgtatt catgggtgtg 1541641 ctgccgcttc agtttaaaca aggtgaaaat gcggatacac tcggcttaac gggtaaagaa 1541701 gtcatcgagg tagatgttga tgaaacagtt cgtcctcgtg accttgtgac tgtaagagca 1541761 atcaatgaag acggcaatgt aacaactttt gaagcagtcg tccgctttga tagtgaagtt 1541821 gaaattgatt actaccgcca tggcggcatc cttcaaatgg tgcttcgtga aaaaatgaag 1541881 cagtcctgat gaatcaatag gaagagaagg catttcgctt tctcttcttt ttatgacaca 1541941 atgtgctgcg gaggtggcat atgctgaaaa aatggctcgc agggatcctg cttatcatgc 1542001 tagtcggtta tacgggatgg aatttatatc aaacatacag caaaaaagaa gtcggaattc 1542061 aagaggggca acaagcacct gatttttctt tgaaaacgct atcaggagag aaaagctctt 1542121 tacaggatgc aaaaggcaaa aaagtgctgc tcaatttttg ggcaacttgg tgtaagccgt 1542181 gccgtcagga aatgcctgcg atggaaaagc tgcaaaaaga gtacgccgac aaacttgcgg 1542241 ttgttgcggt aaatttcact tcagctgaga aaagtgagaa acaggtccga gcgtttgctg 1542301 atacttatga cttaacgttc cccattctga ttgataaaaa agggatcaat gctgactata 1542361 acgtgatgtc atatccaacg acatatatct tagatgaaaa aggtgttatc caagacatac 1542421 atgttggcac catgacaaaa aaagaaatgg aacaaaaact ggatcttgat tagattcagt 1542481 tttttttata ctcaaatatg cttacaagtt ttcagaattg gaaaaaataa aagaatatgc 1542541 ggaggtgaga agcgtgaaga agatgagaaa acgttctttt catgagctcg tcatggaaaa 1542601 caaaaaagag ctgatgacca atacagagta tttaaatcag cttgaggaaa agcttgaaca 1542661 gcgatttaag caaaaataac ctttaatttg tattcatgtt tacccctcct tttgagaaac 1542721 ctatctgttg aggagggata aacatgggaa acaacaagaa aaacggtcag cctcaatatg 1542781 ctccaagcca cttgggtaca aagcctgtaa aatataaagc caataaaggg gaaaaaatgc 1542841 atgatacttc aggacagcgg ccgattatca tgcagacaaa aggcgagtag cgaaaattcg 1542901 agtttatttc taggaggtac atccgaatga caaagaacca aaatcaatat cagcagccta 1542961 atcctgatga tcgttctgac aatgtggaaa aattgcagga tatggttcaa aatacaattg 1543021 aaaatataga agaagcagaa gcatcaatgg agtttgcttc aggagaagat aaacagcgta 1543081 tcaaagaaaa aaatgcaagg cgcgaacaga gcattgaagc gtttcgtaat gaaatacagg 1543141 acgaatctgc agcgagacaa aacggatacc gttcttaaaa aaccagggaa acctggtttt 1543201 tttctttctg atttgattat ggtaaaatgg ggctaaattg acgttaaggg agcagagtaa 1543261 tcttgcatgt atcaaaaaaa gaaatagaag tgcgttatgc agaaacagat caaatgggga 1543321 ttgtctatca cgcaaattat cttgtgtgga tggaggtcgg cagaacggcc ttgattaagg 1543381 acttaggctt tttatatagt gatatggaaa aaaaaggcgt tctgtcccca gtcgttgata 1543441 tcaatatttc ctataaaaag ccgcttcatt acggagaaac cgcggttgta catacatgga 1543501 tagaggacta taacggattt aaaaccgtct atggttacca catttataat ccggccggtg 1543561 agctttccat caaagccacc tcatctcata tttgtgtgga taaagaaagc tttaagccaa 1543621 ttcaattccg caaagctttt cctgattggc acacagcata tgaaaaggcc aaaaaatagg 1543681 gaagtgaacg ggatatggcg tttggtgtga aacgggagga acttaaccgg tggaaacaag 1543741 cagtgaaaag aggagaaatc gcatttttaa cacattactg gctggatgac cgatttccag 1543801 aagcaaagac cgtgacaaaa gccggctgtg cagacattga taagctggtt cagtggggag 1543861 cggcgtacgg gttaaaaaaa gaatggatcc ataagaaaag tgaatttccc cactttgatc 1543921 tgctggggga aacacaaaaa tatattttgg aacaagaaaa cctaaccgat catcttatac 1543981 gatttcattt gtaaaaaaag aacgcacatg aagtgcgttc ttttttattg gtattcaaaa 1544041 accggttcat cagcgtcttc tgaatagctg acgagaaggt cgtggttatc aaagtaccat 1544101 aaatcacttt cttcaataaa gaaggtaatg ccatcagctt ctgcagtgac tccagcctct 1544161 tgtggggcat ctttcgctac accgagagaa aaaccctttt gaacgttgct gcagcctcca 1544221 tagcggacga aaaagcgaac ctggtctccg ctttccaaat cgagttcttc tttataccag 1544281 ttcaatgcgt cttcgttaat tgtcatattc ataacagaac acccctttgt tcttcatttg 1544341 aattttctct attataaacg tattaggcta ttctgtgtca aaagagaagt tttttaagct 1544401 tataaccatt ttactttagg ttctgtttta ttgataattc gtttaatgtt cgctcggtgt 1544461 ctgtatatca caaaaatagt gagcagggta acgacaatca ataaatacgt atcatggaca 1544521 aagaaactat atataacagt atagatccct gttaacatcg atgagagaga aacaaattta 1544581 gtcaagtata aaaagatgaa gaataccgca accatcgtga taaataacag gggtgcgtaa 1544641 aatagcaaaa cgcctcctga tgtcgccacg gctttaccgc ctttaaattt ggcgaagatg 1544701 ggaaacacgt ggcctaaaac cgcaaagact cctgcaagaa gcgggtgaat atcaacatgc 1544761 atgagaaaag gcaatgcagt tgccagtgtc cctttcaaaa tatctccggc tatgacgacc 1544821 gaaccagctt ttacacccaa tgtacggaat gcattggtag cgcctaagtt gccgcttccg 1544881 tgctcccgaa tatcaattcc tttggcaagc ttgcccacaa ttaagccaga tggaatgctg 1544941 cctatcaagt aggccaaaat aatcaataaa gcaattaaca tctacatttc tcctttttca 1545001 aattcccttc tttttatttt aacatgagat gtcatgatct gatgataagt ttttttgtaa 1545061 agtttgctta caaatcaaat caaacatgca tcatattttg atttctcctg ttttgatcgt 1545121 gtaaaataag tgaaaaagga gtgacacacg atgcaaaacc cttctaaagc ggaaattaaa 1545181 gagattcttc aaagaagcaa acgtatagcg gtagtagggc tttcagaccg tccggataga 1545241 acgtcacata tggtttcaaa agcaatgcag gacgcgggtt atgaaattat ccctgtgaac 1545301 cctacaattg atgaggcgct aggtgtcaaa gccgtttcat ctttaaaaga gatagacggt 1545361 ccgattgaca tcgtaaatgt attccggcgc tcagaacagc ttcctggagt ggcggaagag 1545421 tttttagaga cagatgcgcc agtattttgg gcacagcaag ggctagttaa tgaggaagca 1545481 taccagatgc taaaagaaaa aggcagaacg gttatcatgg atctgtgcat aaaagtggca 1545541 cacgctgtaa caaaataggt gcagaactgc aaaaatcctt gtaaattcaa ggatttttgc 1545601 tttttaattt taagatattg tttgcgtatt acggtgaaac agatacaata aagcttgaac 1545661 agcttttttt gaataccttg tccagctggg tttcggccgt tcgatttgcg aaggtctgct 1545721 gctttatata taataaacaa acatacgttc tcatagtgta aaaacagcac tagccgatgt 1545781 tttgagaaga actgattcgt tagctctatg ttgcgattgc aaacatattg gttataatga 1545841 ggagtccaag gcagtactgg ctcgaggcga ggtttataaa aaatatctta tatacaaatg 1545901 atgtgtaaca ctgaaaagag aaagacaatg ttagtttttg aaaggggttt gtacgtttgg 1545961 ctagaaaaca gcaatttgat tacaacgaag atgccataca ggtgctcgaa ggccttgagg 1546021 ctgtcaggaa aaggccgggt atgtatattg gctctactga cgcgcggggt ttgcaccact 1546081 tggtttatga aattgtagat aactctgtcg acgaggtgct tgccggccat ggagatcaca 1546141 taatcgtcaa aatacataaa gacaatagta tttctgtaca ggatagaggc cgcggcatgc 1546201 cgaccggaat gcataagctc ggcaaaccaa cccctgaagt gattttaacg gtgcttcatg 1546261 ccggagggaa attcggccaa ggcggctata agacaagcgg cgggctccac ggagttggtg 1546321 catcagtcgt gaatgcttta tctgaatggc tgacggttac cattgagcgg gacggttttg 1546381 tctatcagca gcgatttgaa aatggaggaa aaccggttac atctctcgaa aagatcggca 1546441 aaacaaaaaa gacgggaact cttacacact ttaagccaga tccaacgatg ttcagcacaa 1546501 ccacttataa ttttgaaacg ctctctgagc gcttaagaga gtctgcgttt ttgttaaaag 1546561 gactgaaaat tgagctgatt gatgaacgca atgaccagcg tgaggtcttt tattatgaaa 1546621 acggcataga agcgtttgtt gcttacttaa atgaagaaaa agacgtcttg tctgaagtgg 1546681 tctcgtttga gggtgagcat cattctatag aagtggactt tgcgttccag tttaacgatg 1546741 gttattctga aaatattttg tcgtttgtca acaatgtcag aacaaaagac ggcgggacgc 1546801 atgagtcagg tgcaaaaact gcgatgacgc gtgcttttaa tgaatatgcg cgaaaagtgg 1546861 ctttgctgaa agaaaaggat aagaaccttg aaggcaccga tataagggaa gggctttcag 1546921 ccattatttc tgtccgcatt cctgaggagc ttcttcaatt tgagggacaa acaaaaggaa 1546981 agctcggtac cagtgaagca agatcagcgg tggatgcgat tgtttcagag cagcttgctt 1547041 actttttaga ggaaaatcgg gacaccgcaa cgcttcttgt caaaaaagca atcaaggcga 1547101 gccaggcgcg cgaagcggca cgcaaagccc gtgaagaagc aagaagcggc aaaaaacgaa 1547161 aaaaatcaga agcgacttta agcggaaagc tgacgcctgc gggttcaaga aacccggcaa 1547221 aaaatgaatt gtatctcgtt gagggagatt cagcaggcgg gtcagccaag cagggacgag 1547281 accgcagatt ccaggcggtt ctgcctttac gcggtaaagt cattaataca gaaaaagcta 1547341 agcttgctga tatctttaaa aatgaagaga tcaatacgat cattcatgcg atcggcgggg 1547401 gagtcggggc agatttctca atcgatgaca tcaactacga caaaatcatc attatgaccg 1547461 atgccgatac tgacggcgcc catattcaag tgctgcttct tacctttttc tatcgctata 1547521 tgaaaccgct cattgagcat ggcaaggtgt tcattgcgct gccaccttta tataaggtca 1547581 gtaaaggaag cgggaaaaag gaaatcattg aatatgcatg gtctgatgaa gagatggggg 1547641 atgtcctgaa aaaagtcggc aaaggctata ccattcaacg atataagggt cttggagaga 1547701 tgaacgcaga ccagctgtgg gaaacgacga tgaatccgga gtcccgcaca cttgttaggg 1547761 tcaaaattga cgatgcggca cgtgtagaga gacgtgtgac gacgttaatg ggagacaaag 1547821 tagagccgcg cagaaagtgg attgagaaaa acgtcgcttt cggcttagat gaagaaagca 1547881 atattttaga aaatgaaaac ttatcggtcg ctgaggaggt ttaatgattg tcacagccag 1547941 aattatttca tgatttacca ttagaagagg tgatcggcga ccgttttgga cgctacagta 1548001 aatatattat tcaagacagg gcgctgcccg atgcgagaga cggattaaag ccggtacagc 1548061 gcagaattct gtatgcaatg catacagatg gaaacacgtt tgataaaaac ttcagaaaag 1548121 cggccaaaac ggtcggtaac gtcatcggta actatcatcc gcacggtgac agctcggttt 1548181 atgaagcaat ggtgcggatg agccaggatt ggaaagttcg taatgtgtta atcgaaatgc 1548241 atggaaacaa tggaagcatc gacggagatc ccccggcagc catgcgttat acagaggcac 1548301 gattatctcc gatagcatct gagcttcttc gggatattga caaaaacacg gttgaatttg 1548361 tgccgaactt cgatgataca agcaaggagc ctgtcgtact cccggcgatg tttcctaacc 1548421 tattggtcaa cggatctacc gggatttcag caggatacgc gaccgacatt ccccctcatc 1548481 atctgggaga agtcattgat gctgtcatta agcgtattca aatgccttct tgctctgttg 1548541 acgaactcat ggaagttatt aaagggcctg attttccgac aggcggtatt attcagggcg 1548601 ttgacgggat aagaaaagct tacgaaaccg gaaaaggaaa aatcattatc cgcggaaagg 1548661 ctgaaattga aacaatcaga ggcggacgag aacaaattgt cattactgaa attccatttg 1548721 aagtaaataa agcaaacctt gtaaaaaaaa tggacgagtt ccgtattgat aaaaaggttg 1548781 aaggcatctc agaggttcgt gatgaaacgg atcgaacagg gctgagagtg gtcattgaac 1548841 tgaaaaaaga agctgatgcc aaaggcattt tgaatttctt atataaaaat actgatttgc 1548901 agatcacata taacttcaat atggtggcta tccataaccg ccgtccgatg ctgatgagcc 1548961 tgccgtctat tttggatgca tatatcggac accaaaagga agttgtcaca aaccggtccg 1549021 tttacgagct tcaaaaagca aaagacagac atcatatcgt agaagggctc atgaaagctt 1549081 tgtctatttt ggatgaagtg attgcaacaa tccgttcttc tagcgataaa cgtgacgcta 1549141 aaaacaattt gatcgcgaaa tatgaattta cagagcctca ggctgaagcc atcgtgtcat 1549201 tgcagctata tcgtttaacc aataccgata tcacagcgct taaggaagag gcagaagagc 1549261 tcggtaaaaa aattgaagag ctcgaatcta ttctgagcaa tgataaaaaa ctgctaaaag 1549321 tgattacaaa cagcttaaaa gcactgaaaa agaaatatgc agatacgaga cgctccgtga 1549381 ttgaagaaaa aattgaagaa attaaaatca atctcgaagt catggttgca tctgaggatg 1549441 tatatgtaac cgttacgaag gatggttacc taaaacggac gagccagcgc tcatttgccg 1549501 cttccaacgg tcaggacttc ggaatgaaag atacggacag gatgctgcat cagtttgaaa 1549561 tgaatacgac agacgtgctg ctgctcttta cgaacaaagg aagctacatc tattgtcctg 1549621 ttcaccagct gcctgatatc agatggaagg acatgggcca gcatttttca aatctaatca 1549681 ctattgaccg tgatgaaacg attgtaaagg ctataccgat aaaagaattt gatccgtcgg 1549741 catatcttct attctttacg aaaaacggta tggtgaaaaa gacagagctc actcattata 1549801 aagcacagcg ttattctaag gcacttgtag ccttaaatct gaagggtgaa gatgaactga 1549861 ttgatgtaca tgtaacaaat ggggaaagcc agatctttat ggccactcac ttagggtatg 1549921 gtctatggtt tggagaagac gaagtgaatg tagttggcgc gcgtgcggca ggtgtcaaag 1549981 ggattaactt aaaagaggat gactttgttg tctccggtga gattcttcag caatctgatt 1550041 caattgtctt gttcacacag cggggagcgg ttaaacgcat gagtctttct gagttcgaga 1550101 agacatcccg tgcaaaacgc ggtgtcgtaa tgctaaggga actgaaaaag aatcctcacc 1550161 gtgttgtagc actgttcgct tgcggtcttg aacagcgact aatggcagaa acagaaaaag 1550221 gcgacagaaa agaactgcag acaaaagagt tgcggacaaa cgacagatac agcaatggct 1550281 ctttcttttt tgatgaagag gaatcaggca aggttacagc tgtttggcgc cttcatacag 1550341 aacaataata aaaaacccgc tcatactata tgagcgggtt tcgtttgttt tttatcagct 1550401 ttcatggttg gtgaatagat ctgttacagc atgaatgact tcaatcccct gccatacaaa 1550461 taaattcagc gctgtgaaag aaaataagcc taaaatcacc attcttaaga taaacaacat 1550521 gtttaacagc ctcctcatat tttcgttaca taatcgggtg atgttgaaca tgaagtttgc 1550581 cgaaataaga cgattgataa aatttggcca gtataaagct ttttttccgc tgacgtctgc 1550641 gggagtatcc cgtacttttg ctttcagcgg tcagcagcag aacagccatt gcccataaag 1550701 cggtcagcgt aaatgcccct gtgatggatt tcttctcatc atcagcattt tggccggctt 1550761 tcatctcatg catttcctgc tggtcggcta cggctttata atgatggccg atatcaaagg 1550821 cgtggggaat tgagaacaaa tgaaaactgg caatcgccaa gaataagatg gatgctttca 1550881 atatcgttac ttttttcaaa tgatctcccc ctcctttaat attactgaat atttttataa 1550941 taatacccca atccatccta aaagtaaacc tgatttatta aatttaaaaa taaatttaac 1551001 tttgttaagt atatatcttt ttgcttattt ttgaaagaga aaacttcttt tattagcgta 1551061 tgtatacccg gtttatggtg tgaataaaaa catattttaa atgatatgtt gtttaggatt 1551121 tattacttta tttatgtgta aatcaaagag aaaggcaaga gaatgggaag aaatgattac 1551181 attgttaata gggtactctt tttttaaagc cagtttgcaa ggaatgtttt tattcgtagg 1551241 aaaataatag agaaggggtc gacagagtaa catctggcta tgacaatatt cttctcgaaa 1551301 aaacttccta attcgtcata ttgtgatata ataaaactcg ttatgttaaa aaatctaaca 1551361 tcaaaatcga attcgtattg aattgatgaa aacgggaggt aaatatggag tcttttttca 1551421 atagtttgat taatattcca agtgatttca tctggaaata cctattttat attttaatag 1551481 ggcttggatt attttttacc atacgttttg gttttatcca attccgttat tttattgaaa 1551541 tgttcagaat agtaggggag aagccggaag gaaataaagg tgtttcatct atgcaggcat 1551601 tctttatttc ggccgcatcc cgagtcggca cagggaattt gactggtgta gccttagcaa 1551661 ttgcgacagg cggaccaggc gctgtatttt ggatgtgggt agtggctgca gtaggcatgg 1551721 cttcaagctt tgtcgaaagt acattagcac agctttataa ggtaagagac ggggaggatt 1551781 tccgcggagg gccggcctac tatattcaaa agggtcttgg tgccagatgg cttggcatcg 1551841 tttttgcaat cttaattacc gtctcattcg gcttgatttt taacgctgtt caaacaaata 1551901 caattgctgg agcattggat ggcgcattcc atgtaaataa aatagttgta gccatagttc 1551961 tggcggtttt aactgcgttt atcattttcg gcggtttaaa acgtgttgtc gctgtttcac 1552021 agctaattgt gccggttatg gcaggcattt atattcttat cgctttattt gttgtcatca 1552081 cgaatattac ggctttccct ggcgttatcg ctacaattgt taaaaatgct ttaggttttg 1552141 aacaagtcgt cggcggcgga ataggcggca tcatcgttat cggtgcgcaa cgcggacttt 1552201 tttcaaacga agcaggaatg gggagcgcac caaacgcggc tgcgacggct catgtatccc 1552261 atccggcaaa gcaaggcttt attcaaacat taggcgtatt tttcgataca tttatcatat 1552321 gtacgtccac agcatttatt attttgctgt acagtgtaac gccaaaaggc gacggcatcc 1552381 aagtcacaca ggctgctctt aaccatcaca ttggaggctg ggcgccgact ttcatcgcag 1552441 tcgcaatgtt cttgtttgca ttcagttcag ttgtcggcaa ctattattat ggcgagacaa 1552501 acattgaatt tattaaaaca agcaaaacat ggctgaacat ttaccgtatc gctgttattg 1552561 ctatggttgt gtatggatct ttatcaggct tccaaatcgt ttgggatatg gcggacctct 1552621 ttatgggtat catggcgctg atcaacttaa ttgtgattgc gctgctgtca aacgttgctt 1552681 acaaagtgta taaagattac gcgaaacagc gtaagcaagg acttgatcct gtgtttaaag 1552741 cgaaaaacat cccagggctg aaaaacgctg aaacatggga agatgagaaa caagaagcat 1552801 aatataaata taaaacaaag ctgcattcaa tagttgaatg cagctttttc attattggaa 1552861 ataaatttaa tttttcgact cgaatgaaaa atgacgtgta aagtcccaat tcagtccagt 1552921 tttctttgtt ctatatgtgt catgtgtgtc ttattcattg gaggtagagc aaattgacag 1552981 gcttttaaac ctccccaaaa caagaaatta ggttgataga caatcatgag aaagattttt 1553041 acaatgagtt cgtgctcata agaagtgtag agccaaaatg atgcgaagga ggaaaagatc 1553101 agatatgaaa cggtcaatct ctatttttat tacgtgttta ttgattacgt tattgacaat 1553161 gggcggcatg atagcttcgc cggcatcagc agcagggaca aaaacgccag tagccaagaa 1553221 tggccagctt agcataaaag gtacacagct cgttaaccga gacggtaaag cggtacagct 1553281 gaaggggatc agttcacacg gattgcaatg gtatggagaa tatgtcaata aagacagctt 1553341 aaaatggctg agagatgatt ggggtatcac cgttttccgt gcagcgatgt atacggcaga 1553401 tggcggttat attgacaacc cgtccgtgaa aaataaagta aaagaagcgg ttgaagcggc 1553461 aaaagagctt gggatatatg tcatcattga ctggcatatc ttaaatgacg gtaatccaaa 1553521 ccaaaataaa gagaaggcaa aagaattctt caaggaaatg tcaagccttt acggaaacac 1553581 gccaaacgtc atttatgaaa ttgcaaacga accaaacggt gatgtgaact ggaagcgtga 1553641 tattaaacca tatgcggaag aagtgatttc agttatccgc aaaaatgatc cagacaacat 1553701 catcattgtc ggaaccggta catggagcca ggatgtgaat gatgctgccg atgaccagct 1553761 aaaagatgca aacgttatgt acgcacttca tttttatgcc ggcacacacg gccaattttt 1553821 acgggataaa gcaaactatg cactcagcaa aggagcacct atttttgtga cagagtgggg 1553881 aacaagcgac gcgtctggca atggcggtgt attccttgat caatcgaggg aatggctgaa 1553941 atatctcgac agcaagacca ttagctgggt gaactggaat ctttctgata agcaggaatc 1554001 atcctcagct ttaaagccgg gggcatctaa aacaggcggc tggcggttgt cagatttatc 1554061 tgcttcagga acattcgtta gagaaaacat tctcggcacc aaagattcga cgaaggacat 1554121 tcctgaaacg ccatcaaaag ataaacccac acaggaaaat ggtatttctg tacagtacag 1554181 agcaggggat gggagtatga acagcaacca aatccgtccg cagcttcaaa taaaaaataa 1554241 cggcaatacc acggttgatt taaaagatgt cactgcccgt tactggtata aagcgaaaaa 1554301 caaaggccaa aactttgact gtgactacgc gcagattgga tgcggcaatg tgacacacaa 1554361 gtttgtgacg ttgcataaac caaagcaagg tgcagatacc tatctggaac ttggatttaa 1554421 aaacggaacg ttggcaccgg gagcaagcac agggaatatt cagctccgtc ttcacaatga 1554481 tgactggagc aattatgcac aaagcggcga ttattccttt ttcaaatcaa atacgtttaa 1554541 aacaacgaaa aaaatcacat tatatgatca aggaaaactg atttggggaa cagaaccaaa 1554601 ttagttaagc ttttttttgg cggacatcag taacgatgtc cgtttttatc atctaatagg 1554661 aggtttgcgt tgtggatgaa atactgaaac agtatatggt gctgtataaa aaaatgagta 1554721 atatgataaa tggtcccgac tatccaggta aggaaaaaga catccagcat caaaaagatc 1554781 agatcgaagt ttacgaaaaa cagctgcagc aaggattttc tacagattat gactatgatg 1554841 tgtttgctga ttctgttatc aaatgcgcat atggcgatat gacgctggaa gatttagaag 1554901 ccgtttatta tggattgaca acaccatttt tttgatttgt cattcagcag taaaatttca 1554961 atttctgtct cactaactta agtatacttt gatattgaga cagaaattta tttattttgt 1555021 ttacttccta gaatatatat tatgtaaact agaaaagatg aagaataaag ctttgctgtt 1555081 tttatgtaca tcctttcttc ttcctgtaat tcagcaacaa aataaaaaag cgatttccca 1555141 atcggaaaat cgccaattca gacactctat tatttatgtg tgtctttgtg ctcttaacga 1555201 tttacaacaa atgttgtcac gctttgagct ggaagatgag cccaaaaatg attgcctgat 1555261 acagtgagat tcgttccagg ttgtagattg ctgctgctgc tcgtgatcca tctagatacg 1555321 tttgaagcag atccattctg caaaacaaag ttttggttga ctcctgtgtt gcttttattg 1555381 atggcaacaa taacgacctt gttgtcacct ttataggctg acacgtaaac gttcgcatta 1555441 gggtttttcg ttgcatcaat ccttacatag ccgggacgca caaactttga gaaatgagcc 1555501 atattgtagc cgcgtttgct gatcgtacca tcttctttca taggtccata tgatcttcgg 1555561 atgtaccacc atacataagc ttgaaagtcc ccctctacca tcgcattgtg aatatgctgt 1555621 gaaacatcca atgcctcagg ccatcgatcc gccgagttgg tatcactgtt tggatagtat 1555681 acttccgtca tccaaaggtc cttccccgct cctttttgtt tgaaaagagg ataagggaat 1555741 tggctgacct gggtgccgta caggtgagtt ccgagaatat ccatattggc aagagcctgc 1555801 ggatcgttca agatcgggtc cgacaaattc ttcaagtatt gaaatgactc aggcgcaatg 1555861 acgcgggcat tgatcgagcc ggcgttttct ctcataaagc gaagtatttc ttgcggcgtc 1555921 caccacgtcc actcgtgagc gtaatcaggc tcgttttgga ccgaaatcgc gtaaagattc 1555981 acaccattat tcttcatgaa ggtaacaaaa tcgttaagat gctgcgcgta tgctgcgtac 1556041 ttgttgtatt tcagccgttt agccgatgtg tcaccattcc gattaaaggt ctcaaccata 1556101 tcacttggag gattccaagg agaagcaaaa acgattgctc cgtgtttgac cgcactcttt 1556161 gcagtctcca cctctttata ccaattattt cgattttcat ctacatgaat tcttaagatt 1556221 gaaaatccta actggttctg tccattgcca aaagcagttt ctctttgagc tgctgtaaga 1556281 tccccagccc aagccggatg attcatccct ccaaaaccgc gaatcacttg tttctctgca 1556341 gatacattaa ctgttacatc acttgctgcc aaaacttcag tagcgcctgg ccctaacatg 1556401 actgacagca tagtgaaaca tactaatagt acacaaattg ttttttttat gcgtggaatc 1556461 atttattcct ctccttcgtc atgtgtcttt tacggtatta aaaaatctgc atggcatatc 1556521 cataatggcg ggctgttccg gtgctggccc gtacttcacc cgcctcgttt ttaagcggtc 1556581 ccattacgag tactatcttt gcgtaaactg ccagtaatca aaattaaaca agtttcctgt 1556641 acctgttccg gtaaatacaa agaatacttt gtgcacaccg gttgccccgc ttaccgcagt 1556701 ttctatttcc ctccacgttt gcgctccgcc tgttgaaggc acattcagag ttccaacaag 1556761 cttaccgtct gcactgtcga ggcgcacttc tattttcccg cctaaagtgg atgctacatt 1556821 tgctttaaat gacctggcac cgcccgctcc gaagtctgca tttcctacag caatccagtc 1556881 tccattttga atgcttgtta catgctgatt atttactggc ccgccgggtg ctgtggactt 1556941 ctctgtcaaa atgcgtccat tccaagcaaa cgtttcagct tctacccggt tatatgggtt 1557001 taaattggaa atttgtgtta cacctgcata atttgccgct acctcttgaa tagatccatc 1557061 tgcattatgc accagcttat taatatgggg agagcggtat cctttgccgg ccccgaacag 1557121 agcggaactg acagtttgcg catggtacac cacataccac tcgtttttaa aattgaaaac 1557181 agcatgatgg ttgtttccgc cacctccgaa aaatgcaccc ggatttttca ggaagtgccc 1557241 tctatatgta aagggaccca tgggacttga actggtcatg tagccgatct cacccggggg 1557301 tttatcggcc gggtgcgtgc cgccgaaatt gatgcaatag gagtaataat atgttccgtt 1557361 atacttgtgc aatcccgaat cttcaaacat gaaaggcgca tcaattgtag atgcacttcc 1557421 aacaacactc gtcatatcag gccccaattt tatgactcta gccgttttag gattggccca 1557481 ttgtccctgc gttggatttg aaacgccagg aacgcctccg ccggcataca ggtaaccggt 1557541 tccgtcgtca tctacaaata ctgccggatc aaaaagccat acaacaccag acattcctgg 1557601 cgtacttggc gttacgagcg gttttccgat tgggtcggtc catggaccaa tcgggctgtc 1557661 tgcggtgaga accccgatac ctccgccgct gtttgcgaaa taaaggaaga atttatcctt 1557721 gccattaatt tttttaactg cgattgacgg tgcccatgac gcacctgccc attttgcaat 1557781 tccacggcct ccattagctc cattggcacc tgctaccgga atggctccgt ggtctgtcca 1557841 gttcaccata tccgctgaag atatgacgaa tactctattc aaattggcaa atgaattatc 1557901 tttaattgtt ccgttgctat tatattcata gtcatcactt gacatataga tgtagactct 1557961 tccgttatag gtcagcgcaa ccggatccgc tcccaaatga tggtcgataa gcggatttga 1558021 attccctata tgttttgcaa ttgtagtact agtggcagca tacgcagact tcccagataa 1558081 gcagctcaat aataaaacta gaatccataa acatacgcta cactttttcc tcatcacttc 1558141 acatcctcct ttttccttaa aatgggggat tttcttttgg aatttgataa caacaggtca 1558201 cgaagattgc acgcataaag tagccggaag ctgtttagca atgttcccag ttgttctgaa 1558261 agctcatctt catgtgtctc cattctctct tttcttcgag gagatcgcac cactccttca 1558321 aaattgttca aaaaaacttc cccattccta gcgaccattg tccagaaaat aaaaagacag 1558381 gattgttcat ggcctcccac taatcacatt gaacggagat tacatcatta tccaagatat 1558441 ccctttatct aacatcctac atcattaaaa aaattgtgta tagaaacttt tggaggagtt 1558501 agtgttcgat tctacaaagg aactggatac atttattcat tgataagatg gggctaacac 1558561 tccgtttata tttgtatgtt ttcagacaca aaaaacagcc gttcaatgcg gctgtttttt 1558621 tcaagagtat aagactattg agcggtatac ccgctttttc atgttttgtt catattttat 1558681 taattgttta ttcaacactg tccgctatag taatccatat caacaaatat gactgccact 1558741 cgcatctttt atgaagggag gttcgttacg ctgaaagaaa aaataaagac attaggccgt 1558801 ttttgcaccg taggcgtcgg caatacgctg atagattttg gtgtcttctt tcttcttacc 1558861 gcttgtcatg tctcttatct gccggcgcag atctgctcct atactgcagg tatcgtcaac 1558921 agctatgtgt ggaaccggaa ttggacgttt tgtgtgaaac gtaaggctga cgggaaagag 1558981 atcgtgcgtt ttctcatgat taatattgcc gcgtcaggga tcaccttttt gctgctttat 1559041 ttgtttcaaa attgcggctg ctcgcttttg gtgagtaagc tcgccgccac tatcggcgga 1559101 atgatgatga attttatcgg aaaccgaatc tgggtatttg gagattcgct gaaaaacata 1559161 caggatcagg agtgaagatg aatgagaaaa aaagtgagaa aagcggttat acccgcagcg 1559221 ggtttaggaa cgagatttct gccggcgaca aaggcgcagc ctaaagaaat gcttccaatc 1559281 gtcgacaaac cagcaatcca atatattgta gaagaggccg cagagtcagg aattgaagat 1559341 atactgatta ttacagggag aaacaaacgc tcgattgaag atcattttga tcggtcggcg 1559401 gaattggaat tcaatctccg ggaaaaaggc aagacggaga cacttaagga aatgcagcag 1559461 attgccgatt tggccaacat tcattacatc cgccagaaag aaccgctcgg attaggccat 1559521 gcggtgctgt gtgcggagca ttttatcgga gatgagcctt ttgctgttct cttaggtgat 1559581 gatattatgg tgtctgaaac accggctctt cggcaattaa tggatgtata tgacgtttat 1559641 ggcacagagg ttgtcggtgt acagtcagtt ctccctgagg atgtcagcaa atatggtatt 1559701 ataaatacat cagggtctca agggcatgta tatgaagtga acgatttagt ggaaaagcct 1559761 tctcctgaag aagcaccttc ggaaatcgca gtaatgggac gttatgtgct gaattcttcg 1559821 atcttctccg ttttgaagac aattggcaga ggcgcgggca acgaaattca gctgacagat 1559881 gcgcttcgtg aggtttgccg taaggagccg atccatgccc ggctgctgga aggaaatcga 1559941 tatgacattg gcgataagct gggctgtttt aaagcgagca ccgaaatcgg cttaatgcgt 1560001 cccgaaatga gatctcagct tttggcctat ttagaagatg tgatcaaacg ggaaacgaaa 1560061 gaaatgctgc ggtaaaaaaa ttgtaaccat cttgctcgtc aatcagtcat ataatagtga 1560121 aaaagattag gacaggttgt gaagaatgtg ggcagtttga taagcgaaat tttaacatgg 1560181 ctgacgaaca tgggatatgc gggtattgcg attgggttaa tgattgaaat cattccgagt 1560241 gagattgtat tagcttatgg cggctatatg gtatcggagg gcacgattgg atttattggc 1560301 gcaattattg cgggtgttat cgggggcacc attgcccaga tctttattta ctggatcggt 1560361 cgctatggcg gcaggccatt tctggacaaa tacgggaagt atttattgat taaaaagcat 1560421 catatcgata tgtcggaaaa ctggtttcag aaatacggcg ccggagttgt cttctcggct 1560481 cgttttatac cggttgtcag acatgccata tccattccgg caggtattgc cagaatgcct 1560541 tttctcaaat ttgtggtact gactgtgctt gctatcattc catggtctat cctgtttgtt 1560601 tatttaggca tacagctagg aagccagtgg gatgatgttg agaatatagc aggcacttat 1560661 acaacaccga ttatgatatt ggctgttgtc gtgatagccc tttattttgt gattaagaaa 1560721 cgtacagcca tatttaaacg atagctagcg gatatgcata ggggtgactg acgctcccct 1560781 atgcatattt ttttacttgc gatgttgatt tgccagcttc agattctccg ctaaaaatgc 1560841 gacaaacact tcatcccgca cgagcgatgc ggcataattt ctcttaataa accattctgc 1560901 ctcttcaaac gctgcgaatg tttcgtcttg ggtttctccg ttaatttgaa tattccattc 1560961 gttgtctaaa gggaaaagaa aaaatctcat ttgtgcgcga ttttcatata atgatccatt 1561021 cgcagatccc tttagattat agatgttacg gaaggcatcc ggccgtacag gatcaatacg 1561081 gaaagcttca gctacaaaca actcgtatac ttcatcggtt attgaacagc cggacgcttt 1561141 tgcatgccct ccgccgccat atcggccggc gatttctgac acatcgatgt aatcatgaat 1561201 ggtgcggaga ctgactcgtt ttgaccccat gctcaaaatc gcaatgtaat cgaggtgcgg 1561261 gttatctttc cctagcctgt tccccagctc tgaatggtac gattcagcgt gaacgatgcc 1561321 tacacagtgt tcgtgaacaa aggtttgtac catttccctt ttctttctgc ggaggtagcg 1561381 ctcgattttt tcgtcttcta aatcaagcag tttttcttca aaatcatcga agaaaaattc 1561441 gtcatgcgtg gaaaggcgct ggatcatttt tgcttcaaat tcatcgattg acagcaaaaa 1561501 gaaaagatca ttaagccgct tcgcctgttt ttgatcgtac cgctcccact cccatgtatc 1561561 gtattggcgg acgagctctg tgaattgatc taaggcgttt gtcggtttca tgaagccatt 1561621 ttcaatgaga tagccatata aaagcgatgt cgcggatgtg agccttccat catcgtattc 1561681 cacctggaca aatccccatt catgctcatt caaatgaagg gctgttttat gatggtcaat 1561741 gagcttcact ttgccccctg catgaacata ctcattcaat ctctcttcgt tttcttcatt 1561801 gacggcgaga tcggtgatga ataacgcgtc ctgtctgttg ctctccttcg ctttttctaa 1561861 aaagtactgc acctgtgcgt ttaagccgtt gacagagtta taccggatct ctacgtcttt 1561921 tccgaacgcc aattttgcta cgattccgca tcctactccg tccaagtcgt tatgtgaata 1561981 taaatgatac ataatgtagg ccccttttta tgataaactg acaattgccg ctagaggtgc 1562041 ggcagccttt atttactatt ctaaaaaacc aagcgtttta tgcaatggta attagttgac 1562101 ataatgttgt tattgtaaat atataaagga gcgctttttt tgcgctccta agttcttgct 1562161 tttacaccgg ataaaccgga tgctttcgat tggtaaatgt catttccttt gtcatgtatg 1562221 ccttgagccg tttggccagc tcatcacgca gcgaattggc tgggataaca gcatcaatga 1562281 tcatttctga agccagacgg tagatattga tgtcctcttt gtattcctcc cgtttgctgc 1562341 tgataaatgc ggctctctct tcttctggca gctcggcgat ttttttagcg tagacagcgt 1562401 ttacagcggc ctcagggccc atgacggcga tttgggcggt tgggagcgct agacagcaat 1562461 ccggttcaaa tgccggccct gccattgcat acaaccccgc cccgtaagct tttcggacaa 1562521 tgacagagag ttttggaaca gttgcctccg acatcgcaga aatcattttc gctccgtgtc 1562581 tgataatccc agcctgttct acttttgtgc caatcataaa accggggata tcggctaaga 1562641 acagcaatgg gatatgaaaa gcgtcacata aggtaataaa cttagccgct ttgtctgctg 1562701 aatcgtggaa taagacgcct ccttttacct tcggctggtt tgcaacaatg ccgacaggct 1562761 gtccgtggat tcgtgcgagg cccgtcaata attccggtgc aaataaggct ttgatctcaa 1562821 aaaatgagtc ttcatctatg acccgctcaa tgagctcatg catatcaaaa ggtgcgtttt 1562881 gattttgcgg aatgacgtcg gcaagcggag tttcgaagtg ttttggcggg cgtttctcat 1562941 gaatgggcgc tttttcttga aaatttgccg gaaagtaaga caaataagcc cgcaccagct 1563001 gtatggcttc ttcttcagtt tctgcaagaa tatctccgca gccggagatt gagcaatgca 1563061 tacgggcgcc acccatttct tcgagagaca ctttttctcc aataaccatt tccgccatcc 1563121 ttggcgaacc taaatacatg gaggcgttac cgtctaccat aacgacgata tcacagaagg 1563181 ccggaatata agcgcctcct gccgcagatg gtccgaaaag cagacagatt tgcggaatgc 1563241 gtcccgataa tttgacttga ttgtaaaaaa ttcttcctgc accgcgtctc cctggaaaga 1563301 cattgatttg gtcggtaatt cgggcgcctg ccgaatcgac taaataaatg agcggacagt 1563361 ttaatttttc ggcgatttct tgaattctga tgattttttc aactgttttt gctccccatg 1563421 accccgcttt cactgttgaa tcattcgcca tgacgcaaac ggtttggccg ccgattttgc 1563481 cgatagcggt tacaactccg tcagcgggaa gcccgtctga catacattcc gcaaaaaaag 1563541 cgtcttctag ctcaatgtca tcgtcaaaga gaagggaaag ccgctctctg acaaagagct 1563601 tgcctttttc ccgattgctt tgatgatact tttccgctcc gccttttcga atccgttcag 1563661 cccgttctgt tcgttccttt tcataatcca tcagcattgc ctccctttta tattcccttg 1563721 tatacggccc gtcttttttc ttgaaaggcc tgaagccctt ctctcctgtc ttttgtcggg 1563781 atggtttgtt catacgcttt ttgttcaatc gcaaggcctg tagcaagatc tgtctccaat 1563841 cctttattga ttgcaaattt agcctgacgg acagcgatcg gtccgttggc agaaatggct 1563901 gcggccagtt cctctgcttt tggcataagg tcacaaggag ccgtgacatg ctctacaagg 1563961 ccgatttctt ttgcttcgtg tgcggtcacg cgtctgcctg tataaatgaa ttcttttgct 1564021 tttcctctgc caatcagccg gggcagcctt tgggtccctc cagcgcccgg gataatagct 1564081 aaccctgttt ccggaagtcc cagcacagct gcttcagttg cgattcgaag gtcgcatgcc 1564141 aatgccaatt ctagtccgcc gcctaatgcg cttccattta tcgcagctat gaccggctgc 1564201 ggcaaggcat caagtaaagc cgccgttctt tgaatgagag atacactttc cagaacctga 1564261 tcttctttca gttttatccg ttccttcagg tctgcccctg cacaaaacgc tttttcaccg 1564321 gtgcctgtga ggatgacgca acggatgttt gagttaaatt caatttcctg gataatcatt 1564381 tgcaggtttc taagcatttc cgctgaaaga gcatttgctg cctgaggcct gtttaaggtg 1564441 atcaacgcca tatgttcatt tttaacagta aaaagaatag aatctcccat tgtatgcgtc 1564501 ctccctttta tcaagatgat ttaaacacct gtaaatttct gctcggcagc ggtttgccca 1564561 ttttttcttc aatccatttg gccgcagata gcagtttttc tagctttaca tttgttttga 1564621 tatccatctg ttcaagcatg tacacgatat cctcagttgc ggcgtttcct gatgaacctg 1564681 gcgcatatgg gcatccccca agcccgcctg ccgagccgtc gaacaccgtg atgcccattt 1564741 ggagtgctgt gaccatgttg gccagagcgg ttcctctcgt atcatgaaaa tgcagggcaa 1564801 tttgattagc cgggaatcgt gccaaaagag cttcaagtac agtttccact tgggcgggat 1564861 tagctgctcc aatcgtatct ccaagcgaca gttcagaaat cccaaattca aatagagctt 1564921 ctgaaaggcg aatgacttgt tcaatgggga catctttttc gtacggacag ccgaaaacag 1564981 tcgagaggta ggctcttgtt gtgaggtttg ctttttgtgc gtcgttgttt acttgtttga 1565041 gtatatggag ggattcagaa gtggatttat tgatgttttt tctgttgtgc gtctcgctgg 1565101 cggacataaa aacgcaagcc tcgttaatgc ctccttcaag tgcattctcc agtcctcttt 1565161 gattcgggac aagtgccgcg tacgttaccc ctttttctcg gtcgatgcct tttgctacat 1565221 cgatagcatc tcgaagcgcc ggaatccatt tcgggtgaac gaaggatgtg atttcaatat 1565281 acgacagccc tgtccgggaa agctggttga tccaggttat tttatcctct gttgcgatcc 1565341 aaacgggctc gttttgtaag ccatcacgcg ggccgacttc tttgattgtc acttttttag 1565401 gatatggcat ggtcttcctc caaattattg agtggaattg ctcagttcga gcagtacgtc 1565461 tccttcattt acaaagtcgc cttccttttt tttgacttct tttacgattc cgcttctatc 1565521 tgcaacgatc gggatttcca ttttcatcga ttccaaaatg gctacctcct ggcccttttc 1565581 gatttggtcg ccggctttga cgtggacttt ccacaggttt cctgccattt gtatgctaac 1565641 cgtcatgaca actgcctcct ttataggtgc tgtttcaaaa agtcagtcgt gacatcccct 1565701 tctttaaatg cctttgttgc cgcagcctgt atgaggagcg gaaggtttgt tttgattccc 1565761 tctacacgat agtcgcgaag cgctgtctct agtttttcaa ttgcttctgt tctggtttgg 1565821 cctttgacaa tcatcttagc gatcatcggg tcataaaaag gggtaacggt gctgtctttt 1565881 gctaccgcac attcgtgtct gactcctttt tggtcaggaa gtgaaaacgc agtgatcgta 1565941 cctggtgacg ggaagaaggt cttgggatct tccgcgtata ttcgaacctc tatcgcatgc 1566001 ccgttccgtt ggatgtcttt ttgggagaat gtgagtgtat ggcccgcagc aatccgcagc 1566061 tgctgctcaa ctaagtccag gcctgttatt tcttcagtca cggggtgttc aacttgcagt 1566121 ctcgtattca tttcgaggaa ataaaaattt tgtttctggt caactataaa ttcgatggtg 1566181 cctgcgttcg tatagccgat tgccttcgct gcttttaccg ctgtttgacc gatcttcatt 1566241 cttagttcat cgtctacaaa tggagacggt gcttcttcaa tgactttttg gtggcgcctc 1566301 tgaacagagc aatcacgttc aaacagatgt actgtatggc cgtgttgatc ggccaaaagc 1566361 tgaacctcga tgtggcgcgc atgttcaata actttttcta tatacataga cccgtcaccg 1566421 aaaaaatctg ctgcgcgctt tttgtttccc tcgtacgctt tttttaatgc ttcttcattt 1566481 tcaacacgct gcattccgat gccgcctccg cccgctgaag ctttcagcat gacaggatag 1566541 ccgatttgac ttgcggtgcg gcaggctgcc tctatatctc cgagggattc agaaacgccc 1566601 ggcaccacag ggacacctgc agcctccatt gcttttcgcg cttcaatttt gctgcccatc 1566661 tttgcgatga tatcagggga aggtccgata aacacgatgt tttcttgctt gcagcgttca 1566721 gcgaaccggc tgttttctga taacaatcca tatcccgggt ggatcgcgtc ggcttttgct 1566781 tttttcgccg tctttatgat tctctctata tttaaataac tttcactgac tctcgattcc 1566841 ccgatcaaat atgcctctgt agcggctttt gtatggggcg cgtccttgtc tgcttctgaa 1566901 taaacagcga ccgttttaat gccgagacgg ctgcatgttc ggataattct cattgcaatt 1566961 tcaccgcggt tggcgatcag tacttttgta aacatgattt cacctcattg acttgatgat 1567021 aagttgaaca tttcaatcgt tttttctcgc agtttatatt tttgaatttt gcctgaggcc 1567081 gtcatcggat agtcatccgt aaaaataaca taacgcggaa ttttgtggcg ggcgattttc 1567141 cctttgcaat aggctttaag ctcatcaggt gaaacgcttt taccgtcttt cagtttaatc 1567201 caggctgcag cttcctcccc gaatttggcg tcaggcacac caaccacctg tacatctaaa 1567261 acagcgggat gctggtataa aaattcttca atttcccgcg gataaatgtt ctcgccgcct 1567321 ctgatgagca tatcttttaa tcttccggtg atgcggcagt acccgtcttc atccatgaca 1567381 gcaagatctc cggtaaacag ccatccgtca tgattgattg cttttctggt cgcatctttg 1567441 tctttataat agcctttcat gacgtgatag ccacgggtgc acagttctcc ctgcatgcct 1567501 ctttgaactt cttgacatgt cccgggttct acaattttca cctcagtatg tggcagggca 1567561 cggccggttg tttcgactct tcttatgaag gaatcatttg ctctcgtttg tgtaatgact 1567621 ggcgaggctt cggtttgtcc ataggcgatc gtaatgtctt tcatgcccat cctttcaatc 1567681 acagctttca tcacttcact tggacaggga gagccggcca tgattcctgt tcggagcgtc 1567741 gatagatcat atgcatcaaa atccggatga tgcagctcgg cgataaacat ggtaggcaca 1567801 ccatggagca ctgtgcattt ctctttttct accgttttaa ggacggtaac gggatcaaat 1567861 tcttgcacgg gtatcatggc tgccccgacg gatacacatg ccaaaacccc aaggacgcat 1567921 ccaaagcagt gaaaaaacgg aacagggatg cacatgcggt cttgagaggt taaagccata 1567981 cattcagcga tattagcagc gttattgatg acattgaaat gggtcagcat cacgcctttt 1568041 ggaaaccctg tcgttcctga tgtgtattgc atattaatca cattgtcttt atccaggctg 1568101 ttcattctct cttcaagctc agcatctgtc actgttttcg ccaatatctc tgtatcgtcc 1568161 caatgataca tgccagacaa tcgtttattg ccaatataga tcagcgtttt taaaaaggga 1568221 tagcgttcag atttcagttg gccgggcttt gcttcttgca gttctggaat taaactgttc 1568281 acgatgtctg gataagaagt gcccctgtat gaatccatga taataagcgc cgcggcatcc 1568341 gattgcttta acaagtaatc aagctcatgt gcttgataat tggtattgac ggtcacgagc 1568401 acggctccga tcttcgcagt tgcgaactgg acggcaagcc attcagagat attagaagcc 1568461 catatggcga cgtggtctcc ttttccaatc cccatccgca tgagaccttt agcggtttga 1568521 cggcacagac tgtcaaattg agcgtacgta tagcggatat ttcggtctgg atacacaaca 1568581 gcatctcgat cgggatacgc atcagctgtt tgttccagca gcctgccgat tgtggaatgg 1568641 atgagttcag ccattcattg ttcctccttt cttaatgata ggaaagcgtt tacattttta 1568701 ttttaaaagc tgtctggcga tcacgagacg ctgaatttca gatgtgcctt caccgatttc 1568761 cattaatttt gcgtcccgca gcatccgttc caccccatac tctttcatat agcctgaacc 1568821 tccatggatt tgaatggctt gattgcaagc tcttgtcgcc atttcagatg cgaatagctt 1568881 ggcgtacgcc gcttctttgg tgaacgggcg gttatgatct ttcagccagg cggcttttaa 1568941 caccatttgc cgtgccagat caatttccat cgccatgtca gcaagcttaa attgaatcgc 1569001 ttgaaaggaa gaaatcggct gtccaaactg ctttcgctct ttcgcatatg ccaatgatgc 1569061 gtcaagggcc gcttgggcaa tgccgactgc aagagcagcg atggagattc gaccaccatc 1569121 cagcgtatat agaaactgtt taaacccttt tgttggatcg ccaagtaagt tggccgcagg 1569181 cactcttaca tcttcaagca agatttccgc tgtattcgaa ccgcggacgc ccattttatc 1569241 gtacgggctc gtaatcgtaa gtcctggtgt gtcagttggc acgattaatg cggagatgat 1569301 gttttttccg tctttgtttt tgcctgttac ggcggttaca ataactgtgc gtgcgtagct 1569361 tgcattagtg atccagcact tttcgccgtt gattacatac tcgtcaccat ttgaaatcgc 1569421 ttttgtttga gtgcctcctg catctgagcc ggcatttggc tccgtcaggc cgaatgatcc 1569481 gagtgctgtg cctgaagcca gcggcgtcaa atgcgtctgt ttttgctctt ctgttccgaa 1569541 gtagtaaaga gggcttgcgc ctagcgagac cgctgcagca tagcttaatc cagtactgcc 1569601 gcaggctttg ccgacttctt caaccgctaa ggcatatgaa atcgtatcac cgccagatcc 1569661 gccgtattct tctggaaatg gaatacccat cagaccgagt tcacccattt ttttaaatgt 1569721 ttgcatcggg aactcgcctg tttgatctac atgttcagcg tgaggagcaa tttctttttt 1569781 cgcaaaatct tttaccattt cacgcaccat ttgttgttct tttgtcagct caaaattcac 1569841 atcgtttcct ccttcacatc tttgtaacat cctattaggc gagttctata atcattccct 1569901 gacaagaaaa gtctgaaaat taaaactgaa tcatttttta tgtgataata tcagcgggat 1569961 gagcaaatac atgcagtagg cgcataccat ccatatcgta aacgcaataa cttggccctt 1570021 tgataaagcc gggaagatga ggggaagatt ccaaagggaa atcgtatcca tcaataaacc 1570081 gaccgctgat ccccatatac ctagcttgat caccgcgaac tgtgattgat cgagtttttg 1570141 atagagaaag aacacaaggc ataaaacaag agcagtgccc gctcccaaga gaagaaagtt 1570201 cggcaaaaag gcttcttcag ccggatcagt caacacagca tctccgaaca gcacaaaaaa 1570261 taatgtggca cctaaccaga ctagaaatga aaacgtaaaa cacgtcctgt acgtgtttct 1570321 cttcgatttt atttttattt agtactagtt tctcagattc caataatggt aaatgtccaa 1570381 acaccgcctc catattcatg tgaatctcac ctttgttttt taaaaaattc agcggtttac 1570441 catcgtttcc tgtcccaaaa tcacttttta aaaaaagacg acttagaaag ccgtccttct 1570501 catttcttat tttgttgttc gtttggaagc tttgctttcg ttatgaagcc ggtctgctga 1570561 agtgacataa tacgtatatt tcttgttggg atctgccgtg ttatctaaga aggtttgctg 1570621 ctcatgtgtt tttctttgcg ttgccagcaa tgttctctgc tttttccctt cggctctgta 1570681 tatcgcataa taggctgttt ctttcgtttt ttgatttgat gggtgatctt taatctgcag 1570741 aagattgccg tttttgtctt cggtgacttt cgtaagcttc ggtttttttg gggcggtatt 1570801 gtcaagccaa ggcatttgcg gaaccagtgc cggcttgctg taaagatcgg tgctgagact 1570861 gtctttgatg ccaagcggat ttttgttgag gtccttgagg ctgaaatgca tgcttccttt 1570921 caccagttca agctggcggt tcaaagtgat ttgccgcaca tattcctcag gatcggacca 1570981 aggcggatca aaattgttat tgattttata tgctgcctgg ccaatatata agtgaacagg 1571041 cctatttttg acttcattgc tccaccaatc agccagcacg tcgtaagccg ctgcgttaaa 1571101 gccgatactc caataaattt gcggagcaat ataatcgatg tcgccttctt ggatccaatg 1571161 ccttgtgtct gcatatagat cgtcataatt tctgacgcct gcttttgtat tcgatccggt 1571221 cgggtcatct gcggcgtttc tccatactcc aaagggactg atgccgaatt tgacatacgg 1571281 ttttgcagct ttaattgttt ggttgatttg tttgacaagc tggttcacat tgtcccgccg 1571341 ccagtcatcg atattagaaa aagcgtcttt tccgtattgt tcgtactgtg cttgatcagg 1571401 aaattcctgt cccgctattt tataagggta aaaataatca tccatatgaa cagcatcgat 1571461 atcataatgt tttacgactt cttcaatgcc tttgacgata aaatctctcg cttctggaat 1571521 gcctggatga taatacagct ggtttccata ggcggcaacc caatctggat gttttcttgc 1571581 cgggtgatcc tcagacaatt tattaagatc tgtatgattc attgtaatac ggtaaggatt 1571641 aaaccacgcg tgaaattcca aatttcgttt atgggtttct tcaatcataa atgcaagagg 1571701 atcatagccg gggtccttcc cttggacacc ggttaagtat tccgaccaag gcccgtaagc 1571761 tgacggataa aaggcatcag ccgtcggttt aatctgaacg ataacggcat tcattcccat 1571821 tttttgcaca tcgtccagca gtttgatata ctcctgtttt tgctctttca cagataaccc 1571881 ttttttggac ggccaatcaa tatttaatac ggaagcaatc catacggctc tcagctccct 1571941 gtcagactgc gcattggcca taaacggaac ggaaatgaca aacgttccga tgatcaagct 1572001 gacaaggaaa cggacaatcg acttttggca aaccttcatt ctgtttcttc tcccccatta 1572061 catcactttc actattcgct attacggtat tcccgggcta taaaagggtg attaacagaa 1572121 tgtctatctc actaaataaa cgaaaaaagt cctaaagcat gttgtgaacc gcttttagga 1572181 ctttttatca ttcatcatgg tttgcagact ttttaacaca tcaataagtt ttacgccgac 1572241 accgacagcc gtttcaagga tcgcttgtgc tccggcaatg gctaaaataa agatcagcgg 1572301 tattgcaata cgaggcaaaa aaagatagcc aagtccgatc aagatggcac accaaacacc 1572361 ggcacaccag tagcaattga gcatgtatcc aaagttagaa gccggcacgc ttttttcatc 1572421 tacatgcccg ttttgatcaa caatcctttt ctttttcata aaaggttttc ggataaattc 1572481 tgtgattttg tcaaatacaa tcaaatgtgt cagcctgtaa ctggctagaa tcagcatgat 1572541 aaaagttaga aaagaaagac ggtccattga gaagcctcca agaaaaagga tgatgttatc 1572601 attcccaagt gtcccttatc cattcttgat acaaaaagaa agacggacag agaatggcct 1572661 ctgtccgcta atccgagctc attccctcca gttctcataa taagaggata agaaaatgta 1572721 gaaaaaagca gaaaaatgac aataaaagaa attatatgac tatataatcc atatatgcac 1572781 tatattaacg gatatttttt aaagtacaat aaaaaacatt aaatttttat aacatttttt 1572841 ttgaatatag tattatttct ttatttttcg tttctttttt tatcaaattt ccggatataa 1572901 agtgataaaa gtattgtttt acataaggtc ttatacacta ctttttaatc ggactaattt 1572961 tcttttgtgc atcattcttc taattgttgg aaggttcgac aaagcgttat tacagacata 1573021 aaaaaacctg ttttctcttg gaaaacaggt ctcccgctat tattgatttg ccaaaatgac 1573081 agcgatttga tcctcaatat cttttccatc ctcttcatca atcaatccat ttagaagaat 1573141 agagaaaaca agtttttttc cgctctttgt ttctgcgtac cccgatagag agcttaccgt 1573201 actgagcgat ccggtttttg ctcttacttt tccttgtgca ggagtgcctt tcatgcggtt 1573261 tctcagcgtt ccgcccacca ttctgtcagg attccccgca acaggtaaag aatttagata 1573321 agccgagaac caactctgat cctgaatgtc atataacagc tgtgaaagtt gatctgagga 1573381 tacagcatca atatgtgaga ttcctgatcc gtcccttaag acgagtgatt tagaatcaac 1573441 accaaattcc ggaagcgtac tgtttaacac ttcgagcccc ttttcccagc tcccttctcc 1573501 ttttttcact ttccccatct cttttacgag cacttcggca tgtccgttat tacttaattt 1573561 catgaacggc acaaaaagtt tcgataaagg cattgagcga tgagagagca gcacatctga 1573621 agaactaggt gcttcacccg tcttgatgtc ccctttcaca gtaatacctt gtttttttag 1573681 tgactgctta aataaatcta aggcatatcc ggcaggctcc cagacagaaa tccattcctt 1573741 tgtcttgttt gcgtcaaccg gtacgctccc ttcaattgta atcgtgtttg ttccatgctc 1573801 tctttcgatt gtgaggtctt tctctgaacc ggcagcagtc gttttagcat cgttctttat 1573861 cgttatataa tcggttttcg gagagacaga cacggcaggc tcttcccctt ctttttgatt 1573921 tggggtgacc tcaacaatca cagtgcctgc atcatagtct tcgtttggag acgctgttag 1573981 agcggagatt ggcgcgccat aatatgtgta ttcatcgctc caaggcatat caggtgataa 1574041 tcgcatgtca tcatgccacg tatcatcacc gatcagattg cctttaatta cttttacgcc 1574101 ggaatgtttc aatatctcag ccattttgtc aaaatcagat ggtaaaagtg tcggatcgcc 1574161 tttccctttc aaataaaggt taccattcag ctttttccct ttcagtgttc catccgtccg 1574221 gacctcggtt gtaaaagaat agttctcgcc aaggacagaa agtgccgcgg ccgctgtcaa 1574281 aagctttaga gaagaggcag gcctcattcg ggtgtctcct gaatgttcat atagaacagc 1574341 acctgtttcc gcagagcgaa cggtgatgcc ggccattgcg ccttcgaggg caggatgatc 1574401 agctaaaatc ttatcgatct gcccggaaag tgcatcttgt ttttcagcgg caagcgcagc 1574461 ctgatgcata taaggcaccg aagcaacgac gaaaagcagt aaaacagcaa cataaagctt 1574521 tatgcttttt ttcattaatt tccccgcctc tctgcgcttc atcattggct attgatgatt 1574581 cagttcaatg gtgatactgc ttttagctgt cgtttcttct cccggctcca gcacttgtaa 1574641 accagtgagt gacgaaggta aatcaagatt cactgcgttt gtcacccatg tgtaaggctc 1574701 agggcataaa tacccttgtt ttccgtccgc attgtataca acccaatgtt taaactgttc 1574761 atctgcctta taaataatgc tgatatgtgc atgctgatga taaatgactg cctggttttc 1574821 tccgcccctc ttctgataag aagataaaaa gacatcatcc agctgcttgt ggcgcaaatc 1574881 cattccttca tgcaaagctt ctttatacgg gacatccatc agcttcccgg tcggcagcag 1574941 gcgttcatcc aactcccatt gctgatctgc tgtcagggag aataacgagc tttctgccgg 1575001 aaatataaat gtagtatgat aaccaattcc ccaaggaaac gcttcctttc ctttgttcat 1575061 gaccgtcgca tgtttaaata gggtattctc cttgatcgtg tatgtcatcc gaacgacggc 1575121 atgatgagga aattgcttct gcacatgggg aagctcagaa agatcaattt ctgtttcaac 1575181 aatcactcct tcatcagttt gcttcgtggt cacgacattc cacttttcat ggtaaagaaa 1575241 cccgtgaaga tggttgtgtt tatccttctc gttgatatca aaatgatacg ttctgccccg 1575301 gaaactgaat gtaccgtcac ttatgcggtt aggcgggaac aggattggaa tgccatacaa 1575361 tgttggtgtg tcgtgaaaac tttctgctgt ttccggttca cgcaaaagct ggacatttgt 1575421 tgttttgtcc acgagagaaa tgacgttgct cccccactca gggacaacaa tcatttctag 1575481 atgttcgttg cccgctttga tggccggcgt tcccaaatac gtgattttct caataaagtt 1575541 tgccatgttt actcaacctc tccttgattc attgctagta taagaattca atgtactgta 1575601 ccatatttcc tccattttat attttcccct atcaaataaa aaaacaccgt tcaaacttat 1575661 gaacggtgtg attcggaggc tattggatga gacgtgtgat ttgtttcttt ttccagacga 1575721 attgataata cccataaatc aacagcaagc tgacggcaaa cgcagctgga taaccaaccc 1575781 agacgccgag tatttcaagc tttgtatagt gagaaaggac gaaagcgaca ggcacctcta 1575841 ctccccagat tgcaaaaata ctgatgacgg tcggccataa aactgttccg cttgcccgca 1575901 tcgttgcaga aataatttgg gcatttccaa acagcaaata gctccacagt gtaatcatca 1575961 aaagacggtg cgcaatgtaa agcgtctctt gctcggttaa aaataacgat aaaatctgat 1576021 gtgaaaaaac atagatcaga atgatcagta cgccgccaat gatataattc agccaaatcc 1576081 caacgcgaat gacctgcttt aagcggtcaa actcgtttgc tccgatcgat tgcgcagcga 1576141 aaatagaaac cgcaatacca aggctgacgg ccggcatctg tacatagctg gccacctggt 1576201 tgaccactcc gtatgcagct gttgcattag agccgtaatg attgacgaat gaaataaccg 1576261 ctatctctga taatgagaca agaatcatat tgatgcttgc tgggacccca agacgcagca 1576321 ggagaaccag cagttcctta tccattttca aataacgacg cactgtttta tcaaattgca 1576381 gcgggtgttt tcgctttcgt aaatacacca ttaacacgag aaaagtcgca atcgtggaaa 1576441 tgacagttgc atatgccgag ccgtatatgc ccagtttcgg aaaaccaaac atgccaagga 1576501 ttaaaacagg caaaagcgcg atgttgatga ccgtgctcac aatcagcgta taaaacggtg 1576561 tcttggaatc tcctgttccg cgcaaaaagg tagtatatgc aaaatataaa aacataaacg 1576621 gcatagcata aaataaaata cgtgcatagt tagcgctgac atgaatgaca ttttcaggtg 1576681 ttcccattaa acgaaggata tccagggtga aaatactgcc gataacggct aacacaacgc 1576741 ctaataaaaa tgtaaacgtg agtgtcgtcc cgacaacagc ctttagccgt tcctcatttt 1576801 tcgctccgta agcttgtcct atcagaatcg aacttcctga accgatccca atcgtaaatg 1576861 agattaaaag aaaaaataac gggaaaaagg atgatacagc tgccactgca tcaacaccga 1576921 gccatctgcc tacagccatc atcccgacta gctggccgac tgattgcagc acattgctca 1576981 gcagaagcgg cactaaaaag agtgacatcg accgccaaac tgatggtttg cttttctttt 1577041 gagttacaag aggttcttgt gatgtttcca tattaaagga ctcctttatt tgaaatcgtt 1577101 tttaaacatg ccctcatttt ttgacaaaaa caggatatgt aacatgttat tattcatcac 1577161 tgcacttatg aaacccttcc cgattcttct aattttacac atctttttag cttatgaaga 1577221 ataaactagc aagtaatggc gtattttttg tgagtaaaag aataaaaaat aatttatgca 1577281 aaagtattgt aatctatccg taattattgt aacatttgta acataagaga aagagatttt 1577341 gaaggagaga gcgataatga aaaaatgtct tctatttcta acaaccattg cacttattct 1577401 gtcattaagc acaaatgcat ttgcgaaaaa tacatcaggc gatttatcac aaaaacaagc 1577461 attacagttg gcattatccg ctagagaaca tttttggaac accatgagcg gccacaatcc 1577521 gaaggtgaaa aaagcagttt gcccatcagg cacattcgag tatcaaaatc ttcaatatgt 1577581 atacatgtgc agtgatctag gcactaaagc aaaagcggtg aattatttaa ctcctatttt 1577641 tacaaaaaca gcaatcgaaa aaggctttaa agattatcat ttcactgttt caaaaggaaa 1577701 acttgctgtt ccaatcggtg acggagacaa tcttttgaat tggaaaaaat caactgctaa 1577761 actgatctct aaaaaaggca gcacaatcac atacgaattt actgtcccta cattagacgg 1577821 atccccttct gcaaaacgga aagtgacatt tgtgaaagaa aataaaaaat ggaaagtcaa 1577881 tcaatttgac gcagttatat aagaaaaacg cccggtataa gcgggcgttt tttatttggt 1577941 ttgcataaag aaagacaaca ggcgaaaagt gcctgttgtc tttttgtgaa tataacgctc 1578001 taggagagat tcgaactccc gacctgcagt ttaggaaact gctgcactat ccgctgtgct 1578061 actagagctt ttggtattta tatagtagct ctgatgatca atattttcaa gcgatttgta 1578121 ttaaagccct ccaaaaacct tatatgcggc tcttgtcgta tcttcatcaa taccgatata 1578181 ccgcattgta attgatggtg atgaatgatt cagtattctc tgcagctcgg cgatgtcttt 1578241 cgttcgctga taaaaatgat agccaaacgt tttccggagt gtatgcgtcc ctatctcctc 1578301 aagtccgcac gctgcagcgg cctctcttaa aattctgtag gcctgaatgc gggaaatcgg 1578361 cttcctggtc cgcactgatt taaaaagata ttcgttttcc ttcatgtctt tcgtatactc 1578421 gtatatttcc tgtttcagcg attctaaaat aagaatcttt cttttctttt tcgttttgct 1578481 ttcagtcgcc cataaatgat ctttattttg aacgtccttc acttgcagcg gcagaatatc 1578541 agaaatacgg agcgcgctgt tgatgccgaa aataaacaga aaataatccc gcttgttttt 1578601 gttaagcaaa tactgtttga cttcttggat tttctctaga ctgcgaatcg gctgtacaat 1578661 atgcatcaaa aaactcctta aaaaccgtta tgtaacattt tgaggtctat gttactatta 1578721 tagctgaaaa acgttgaatg tcaaagtgcg gcggcgttta tgtaacataa tatacatagt 1578781 gttacataag cttttaaaaa agcttcttcc aaccttcacc ctataaaata agctttaaag 1578841 cctcttataa agcttttaac ctcttggata cttatccccc tactaatcat caaaaaacct 1578901 cttaaaatga aatctgacac tcccaatttt ctggagcttc cgcaaaaata tacaaaaaaa 1578961 gacacaattt caaattgtgt cctaatcctc atcctttaca tcaatatctt ccgggatcgg 1579021 ttcatttaat atttcctgca caagtgcttt gtaattctcc agctgttcga gatgcgtttt 1579081 gaactgttcc ttataaatca aaaattgctc cccgtcatga acggctctga ttttcccttc 1579141 gagcaccaag cttttaatat aatcctctga aagatttgta tattctgctg tttcttcaat 1579201 cgttaaatac atatagcagt cccttcttaa tccgtatgct gattctaata tagcacatgg 1579261 ctcatatcaa tataatcaat tctgcacaga aaaacggcat tatgcactat ataatatacc 1579321 atttgtcact tgtgaaaacg ctgtaatttt tttacgctaa gattgtaaca atacagcttc 1579381 atataggagg gagaacatga aaagaacgtg gaacgtctgt ttaacagctc tgcttagtgt 1579441 tctgttagtc gctggaagtg tcccttttca cgcggaagct aaaaaaccgc ccaaaagcta 1579501 cgatgagtac aaacaagtag atgttggaaa agacggcatg gttgcgaccg cacatcctct 1579561 tgcttctgaa atcggtgctg atgtgctgaa aaaaggagga aatgctattg acgcagcggt 1579621 tgccattcaa tttgcactca atgtaacaga gccgatgatg tcaggtattg gcggcggcgg 1579681 ttttatgatg gtgtatgacg gaaaaacgaa ggatacaacg ataatcgaca gccgtgagcg 1579741 tgctccagca ggcgcaactc ctgatatgtt tctggacgaa aacggcaaag caattccttt 1579801 ctctgaacgt gtaacaaaag gtactgccgt tggtgttcca ggcactctga aagggctgga 1579861 agaagccttg gataaatggg gaacccgttc gatgaagcaa ttaattaccc cttctattaa 1579921 actcgctgaa aaaggctttc cgattgattc ggtgttggca gaggccattt ctgattatca 1579981 ggaaaagctt tcacggactg ccgcaaaaga tgtattttta ccaaatggcg aaccgcttaa 1580041 agaaggagat acccttattc aaaaggattt ggctaaaaca tttaagctta ttcgctccaa 1580101 aggcactgac gctttttata aaggaaaatt cgccaagacg ctttctgaca ctgtccagga 1580161 tttcggcgga tcaatgacag aaaaagattt agaaaattac gacattacaa ttgatgaacc 1580221 gatttgggga gattatcaag gctatcaaat cgctactact cctcctccaa gctccggcgg 1580281 tattttctta ttgcaaatgc tgaaaatcct tgatcatttt aacctttcac aatacgatgt 1580341 ccgctcatgg gaaaaatatc agctgcttgc tgaaacgatg catttgtcat atgccgaccg 1580401 tgcgtcttac gcaggtgatc ccgaatttgt aaatgttcct ctcaaaggcc tgcttcaccc 1580461 cgattatatt aaagaacgcc agcaattaat caacctagat caagtgaata aaaaaccgaa 1580521 agccggtgac ccttggaaat accaagaagg atcagcaaac tataaacaag ttgaacagcc 1580581 gaaagacaaa gtagaaggcc aaacaaccca ctttacagtt gctgaccgtt ggggaaatgt 1580641 tgtttcttat acaacaacaa tcgaacagct attcggaacg ggtattatgg tccctgatta 1580701 cggtgttatt ttaaacaatg aattaacgga ttttgatgcg ataccaggcg gagctaacga 1580761 agtacagcca aacaaacggc ctttaagcag catgaccccg acgattttat ttaaggatga 1580821 caagcctgtc ctcacggttg gatctcctgg cggggccaca attatttcat ccgttttgca 1580881 aaccattctc taccacattg aatatggtat ggaattaaaa gcagctgttg aagagccgag 1580941 aatttacaca aacagcatga gctcttaccg ttacgaagac ggagttccta aagatgtcct 1581001 cagcaagcta aacggcatgg gccacaaatt cggcacaagt ccggtggata tcggaaacgt 1581061 gcaaagtata tcgatcgacc atgaaaacgg cacctttaaa ggtgtagctg attcaagcag 1581121 aaacggcgcg gcgatcggca ttaatttaaa acgtaaataa ataaaaaact gtactcgctt 1581181 caaatgagta cagttttttc atgcagatct ttaaaataaa aactgacaaa cgtctttatt 1581241 ctgctaatgc acgtctatct tcatcttttc atttcgttta tctcatcaag aaatgtctga 1581301 aacgcactcg taataaaaaa gtctttcctg tatataaaga cgatctctaa gtcttgatat 1581361 gatggtggca gctgatgaat ccatacattt gtacgatgct cggagccgtc aacagcggac 1581421 tttgggagca gcgccgtacc catcccggcg gaaacacctt ttataatagc ctccaatgtg 1581481 ccaaactcta tgattttttg attgtgtatg cctgcttcct ctagtaatct tttgaccctg 1581541 tcacgatgag aacagccagc cccaaaaaag agcatcggct gctgaagcat gtcttctgcc 1581601 gtcccttctc gtgatgaaat caaaactaat tcatcatggg agacatggag ttgtctaact 1581661 gcagcgtgtt caaccggccc atatacaaaa gcgccatcaa ctttatgatc aagaacctgt 1581721 tgaatcaaat gatgcgtatc agctgtgttc actgataaat ccacttcagg aaaacgcctg 1581781 aggaaggatg ctgcatgctc aggcagatgc gttaccgcca ttgtttccag tgatccgatc 1581841 cgcaaaggcc cttttggttg cctgctcatt cgggtcgatt tttcagcttg gtctaacagc 1581901 gataatactt gatctgcata ttgtaaaaga ttttctcctg cagcagtcag cttcattccc 1581961 cgattcgttc gatgaaaaag cctgatattc aaatcttcct caaggttatg cactctggct 1582021 gtcacattcg actgaacata attcagcatt tgggctgctt tcgttatgct tccttcgcga 1582081 gcaacagcct gaaaaatctt taaatctccg ctttccacgc gctctcacct gcttgctatg 1582141 atgaaaagtg atattggcta tcatatttgt tcattttact cgaagaaaac cgctatgtaa 1582201 aatatgtaaa gatatgaaaa tacaattaat gaggaggcag acagcatgaa agctgtaatt 1582261 cacaacggaa aagccggtct tctggggtta tcagttcagg acgttccatc aacaaagcct 1582321 ggatacggag aggtaaaggt taaattaaaa tctgcaggcc tgaatcatcg tgacttgttt 1582381 cttatgaaaa acaaatctga acaagatcct cacatgatac tgggttctga cggcgcgggt 1582441 atcatcgaag agattggtga aggcgtgaaa aatgttactg ttcagacaga agtagtcatt 1582501 ttcccgacat tgaactggga tttgacagaa aatgttccac ctgtacctga gattctggga 1582561 ggtccttcgg acggaacact tgctgaatat gtgatcattc cttcacaaaa tgcaatcaaa 1582621 aaacctgctt atttatcttg ggaagaagcg ggcgttttac ctttatccgc tttaactgca 1582681 tatcgggctc tgtttacaaa ggggcaatta aaaaaaggcg agcatctatt gatacccggc 1582741 atcggcagcg gtgtagcaac ctacgcttta tttatggcta aggcgattgg ggcaacagta 1582801 agcgtgacct cccgcagtga ggagaaaaga aaaaaggcgc tgaaattagg tgctgattac 1582861 gcatttgaca gctacagcaa ttgggatgag cagttgcagg gaaaaaagat agatgttgtt 1582921 cttgacagca taggacctgc cctcttttcg gaatacttcc gccatgtaaa accaaatggc 1582981 cgtattgtca gctttggggc aagctcaggg gataatctca gttttccggt gcgttcttta 1583041 ttctttcctc aggtcaatgt tttgggaacc tcgatgggaa gcggtgagga atttcaagct 1583101 atgctcgctt tcattgacaa acataagctg cggcctgtaa ttgaccggat atatccttta 1583161 gaaaaagcat gtgaagcata taaaagaatg caggaaggca gacagtttgg aaacatcggg 1583221 atcgtaatgg aataaaaaaa gaaaccggct ggcagccaga ccggtttctc ttatatgata 1583281 atccccttta tttacggaag aactgaactc cccatcaaat atcgatccac ttcacgcgcc 1583341 acttcacggc cttcattaat cgcccatacg attaagcttt gccctcttct tgcatcccct 1583401 gcggcgaata caccatcgat atttgtttga taatccccat atgctgcact gattttgtta 1583461 tttactgaat taacaccgaa ctgtttcaac agcggctgtt ctgtgccttc aaagccgata 1583521 gcgataaaga caagctgagc aggccatact ttttccgttc caggcagctc gcggaactcg 1583581 tattttccat gctcattttt cactttttcc atttggatgg tatgaagctc tttcagcttt 1583641 ccgtttttat ccgcgaccat ttttgtcgtt tgaatggagt attctctcgg atctcttccg 1583701 aattttgctt ctgcttcctc gtatgcatat tcaagcgtaa agacgtgtgg ctgttcaggc 1583761 cacatattgt cattcgtgcg ggctggcgga agtttcgggt gtttgccgaa ttggtgcacg 1583821 cttttggctt tttgacgcag agcggtagcc acacagtcag ctcctgtatc tccgcctccg 1583881 attacgatga catctttccc tttggcatca atgaattgct tgtctttaaa attagaatct 1583941 aaatagcttt ttgttgcaag tgtgaggtag tccattgcgt aatggactcc ttttgagtcg 1584001 cgtccttcga ttaagaggtc ccgctgtttt tgagcgcctg tgcataagat cacagcatca 1584061 aattgctcct ttagctcatc agctgtaatg tcaacaccga tttctgtgtt cgtgacaaaa 1584121 tcaattccct cttgcgtcag caatttaatt cggcgttcta caatgccctt ctcaagcttc 1584181 atgtttggaa tgccgtatgt taaaaggccg cccgctctgt ctgctcgttc aaaaacagtg 1584241 acggaatgtc ccgcttgatt cagctggtca gcactcgcca gtccggctgg gcctgacccg 1584301 acgatggcca cttttttgcc tgttcgtttt tttggaattc taggttgaat ccagccgttc 1584361 tcaaatcctt tatcgataat ggtccgctcg atgtttttaa ttgatacggc cggatctgaa 1584421 atcgctaaag tgcatgatcc ttcacaagga gcggggcata cccgccctgt gaattcagga 1584481 aagttgtttg ttttcaacag acgttccaat gcttccttcc atctgccccg gtagacaaga 1584541 tcattccatt caggaattaa gttgtaaatc ggacagccgg atgtaaatcc gttaatgtcc 1584601 gcaccgatct ggcaaaacgg tgtaccgcaa tccatacacc gcgccccttg ccgtttcgat 1584661 gcttcttctg aaaaaggagc agaatattct ttccaatcct ttaagcgagt gagagggtcc 1584721 cgctccgcag gtttttctcg tttgatctcc ataaatccag ttggtttccc catgttcctc 1584781 tccccttcct tactgtacta ccgcttgttt ttgtcccgat gctgctgtat tctgctttgg 1584841 cttcgtgttg gcctcaaaag cgaacatgat ggcttcttca tctgataaac ctgcagcttt 1584901 ttgctcttcg atgcttgcga gcatttgttt atagtttttc ggaatgactt tgacgaattt 1584961 tttcacactg tcttcccatt gatctagcag atcttctgct ttttggctgt ttgtatacgc 1585021 agtatgtctt tcaagcattg ctttgatttg ctggatttct ttctcatcct ctaatgattc 1585081 aaataaaatc atctcaaggt tgcatttgcg tttaaacgct ttgacatctt cggtcagtac 1585141 ataagcgatt ccgccggaca tacctgccgc aaagtttttg cctacatcac cgagaacgac 1585201 aacgctgccg ccagtcatgt attcacagcc gtggtcgccg atgccttcta caactacgtt 1585261 cacaccgctg tttcgaacgg caaagcgttc accagcacgc ccgttaatat atgcttctcc 1585321 gcttgtcgca ccgtaaaaag ccacgttgcc gataatgaca ttgtcatccg aagcagagtt 1585381 gaatccttct gatgacttga cgatgatttt tccgccagaa agcccttttc cgacgtaatc 1585441 atttgagtct ccgtccaaat aaagcgtcat ccctttagga acgaaagctc caaagctttg 1585501 gccggctgat ccggtaaagt gcagcttgat tgtatcttca ggaagacctt cttctccgta 1585561 acgctttgag atttcactgc cggttatcgt tccggctaca cgatttgtat tattgatttc 1585621 aatcgaaata tcagcttctt ttccagattc gatggcttct tgtacggccg ggagaattgt 1585681 tgtaatatca agtgattgat caattttatg attttgcggc gattggaacg tccgcacccc 1585741 ttcaggctga taaagaaggg tagacaaatc aagctggctt gctttccagt gctcctttgc 1585801 ccgttcactt gcatgaagta catcagtgcg gccgatcatt tcatcaaatg tcttgaagcc 1585861 taacgcagcc atgtactcac gaacttcttc ggcaatgaac agcatatagt tcacaatatg 1585921 gtcaggatct cccatgaact ttttgcgaag ctctggattt tgtgtcgcta caccgacagg 1585981 gcatgtatcc aaatggcagg cacgcatcat gacacagccg agtacaacta acggagccgt 1586041 tgcgaaacca aattcttcgg cgccgagcaa ggcagccatc acaacgtcgc ggcccgtcat 1586101 gagctttcca tctgtttcta atacaacacg gtcacgaagt ccgttcagca ttagtgtttg 1586161 atgtgcttct gcaaggccaa gctcccacgg aagccctgta tgtttaatac tggttttcgg 1586221 agaagcgcct gtacctccgt catagccgct gatcacaatg acatctgcag tcgctttggc 1586281 aacacctgca gcgattgttc ctacacctgc ttttgacacc agctttacgc tgattcttgc 1586341 gtcacggttg gcatttttca aatcgtggat cagctgggct aaatcctcaa tcgaataaat 1586401 gtcatggtgt ggcggaggtg agattaatcc gacacctggc gttgacccac ggacatcggc 1586461 aacccatgga tataccttgt tgccaggaag ctgcccgcct tcacccggct tagcaccttg 1586521 agccatttta atctgcagct catcagcatt gacgaggtaa tggcttttga caccaaaccg 1586581 tccggatgca atttgtttga tcgcacttct tctatcatcg ccgttctcat ctggaacaaa 1586641 gcgtttggga tcttctccgc cttcaccgct gttgcttttt cctccaagac ggttcattgc 1586701 gattgctaaa gcttcgtgcg cttccttact caaggacccg aatgacatcg cacccgtttt 1586761 aaaacgtttg acaatcgatt cagcggattc aacctcctcc aacttcaaag gcttgcggtt 1586821 tccgtcaaat gcgaacaagt tccgcaaaaa tccgatgcgt tcttcatcag ccgcttttgt 1586881 atactgttta aacagattgt aatcatttct gcggcacgcc cattgcaaag tatgaatcgt 1586941 tttcggatta aacgcatgat gctctccgcc atttctccat tggaagtcac ttcccggttc 1587001 aagcgttttg ctgtaatcat cctgatacgc ttcccggtgg cggcgctgtg cctcttctgc 1587061 aattgtttgt aaatcgatgc cgcctagctg tgatgcagta cctgagaaat agcggtcgat 1587121 cacatcgcgg ctgattccta ccgcctcaaa gatttgtgcg cctctgtagc tttgcacagt 1587181 tgaaattccc atcttggaca tcacttttac gacgccctca gtaatgcttt ttccatattt 1587241 gctaaccgct tcttcatagc tgatatccaa acggccttca tcaatttcct gcttgtaggt 1587301 cgcataagcg agataagggt taatcgcatc tgcgccataa ccgattaacg ctgcaaagtg 1587361 atgcacttca cgtgcttctc ccgattccac aataatgctg accttcgtac gcagcccttt 1587421 gcggattaag tgctggtgca gtgcgcttac tgccagaagc ggcggaattg gtgtcagtcg 1587481 ttcgttcatc tttttgtctg ataaaattaa caaacttacg ccttggctga tggctttctc 1587541 tgcctgtgtg aacatgtcct ttaaaccgcg ttcaagatcc tctgaaaaca gcacatcaat 1587601 tttttggctt tttaaatcag gatgaacaat cgttttcaat gcgtaaaact gttcattgga 1587661 taaaacaggt gtatacagtt taatccggcg aacatttcgt tcacttggat gaagaagatc 1587721 gccttccgca ccgagccaag tcatcgttga agtgacaagc tgctcacgaa tcgcgtcgat 1587781 tggcgggttc gttacttgtg caaacagctg tttaaagtag ttaaacagcg attgcgctcg 1587841 gtcagaaagt acagcaagcg gagcgtcatt ccccattgaa ccaaggggat ctttgccttc 1587901 tttaataaca ggaattagat acttttggat atcctcatat gtgtatccga atgccttctg 1587961 gcgagtaaga agatcactaa attgttcttc ttctcttgac tccggatcag gatttacttg 1588021 tacaagctct tcttcaagcc atttttggta cggatactca gttgcaattt gtgttttgac 1588081 ttcctcatcg gagataatac ggccttcttc caggtcgatt aaaagcattt tcccaggctc 1588141 aaggcggttt ttatataaaa cgttctcctg ttcaacttca ataacgccta cttcagatga 1588201 gaaaataata taatcatctt ttgtgacata ataacgggcc ggacggagac cgttccggtc 1588261 aaggatcgcc ccgatttgtt taccgtcagt aaatgaaata gctgtcggtc cgtcccaagg 1588321 ctccatcagg gagctatggt actcgtagaa cgcccttttt tccttggaca tatgcgtatt 1588381 ttccgtccaa ggctctggaa tgagcatcat tgccgtatgt gccggtttgc gtccagccat 1588441 cacaaaaaac tcaaatgcgt tatccaaaat ggaagagtca ctgccatcag cattgagaat 1588501 cggcaaaatc ttgtttaagt cctcaccgaa gctttcagaa acaaattgct gctcacgtgc 1588561 tctcatccag ttgatatttc cgcgaagggt gttaatttca ccgttgtgaa ccaaatagcg 1588621 gttaggatgc gctctttccc atgtagggaa tgtattggta ctgaagcgtg aatgaacaag 1588681 cgcaaaagca gaaacgaatg cttcgtcttg cagatcagaa taaaatgcat caacctgttc 1588741 aggtgttaaa aggcctttgt aaacaatggt ctggcttgaa agactggcaa aataaaaatc 1588801 aagaccttcc gttactcccc aattttcagc ctgtttacga atgacataca attttcgttc 1588861 aaaagataaa ttgtccttta gatcagaact tgcgccgata aatacctgac ggacaaacgg 1588921 acagcttttt tgcgccactg ttccgatttt tccgacattt acaggtacag ttctccatcc 1588981 aagaacgact tggccttctt gttcaattag tgcattgatt tgcttttcaa ttttttttct 1589041 ttcatcttcc ttctgtgaga aaaagaccat tcctaccccg taacgttctt tttctggcag 1589101 attgatgttt ttgcactctt ttctaaagaa agcatcaggg atttgaacca gtaagccggc 1589161 tccgtctcct gtatccggat cactgccttg ccctcctcta tggtctagct ggcaaagcat 1589221 cttaagtcct tgtttgacaa tgtcgtgagt ctgcttgccc tttaagtgtg catataggcc 1589281 gattccgcat gcatcatgtt caaattcagg acggtagaga ccttgagctt ttggcatttg 1589341 attgtacgtc ataattcctc tcccccgatc aatttccgat aataccggtc ataaaatcta 1589401 acaactctat aatcattgta ggttttcaaa acgatataaa caatatataa tttagatcaa 1589461 aagaatctca aaatgagata gatggatgtg agacaaacat ggagctgcgc caactgcgtt 1589521 attttatgga ggtggctgaa agagaacacg tttcagaagc cgctgatcat ttgcatgtgg 1589581 cccaatcagc aatcagcaga caaattgcca atcttgaaga agaattaaat gtgaccttat 1589641 ttgagcgtga agggagaaat atcaaactca cgccaatcgg aaaagaattt ttaattcatg 1589701 tgaaaacggc gatgaaagcc attgattatg cgaaagagca aattgatgag tatcttgacc 1589761 cgcatcgcgg aacggtaaag atcggctttc ctacaagcct cgccagccag cttttgccga 1589821 ctgtcatttc agcgtttaaa gaagaatatc cgcacgtcga atttttgctg cgccaaggct 1589881 cctataagtt tctgattgaa gctgtcagaa accgcgatat tgatctggcc ttattagggc 1589941 cggtgccgac gaatttctct gacataacgg gaaaaatatt atttactgaa aaaatttacg 1590001 cgcttgttcc attaaatcat ccgcttgcta aacaaaaaac ggttcattta atcgatttgc 1590061 gcaacgacca atttgtattg ttcccggaag gatttgtact tagagagatg gcaatcgata 1590121 cttgcaaaca agcaggcttt gctcctctcg tttccacgga gggtgaggat ttggatgcga 1590181 tcaaagggtt agtgtccgca ggaatgggcg ttacccttct gcctgaaagt acttttgctg 1590241 aaacaacacc tcgttttact gtgaaaattc caattgagtt ccctcaagta aaacggactg 1590301 tcggaatcat taaaccgaaa aatagagagc ttgcgccttc cgcgaatgat ttttatgagt 1590361 ttgtcattca atttttctct aagctggagc agtatcaata aaaaaaatga acccgagctt 1590421 ctatatagaa gcttcgggtt tttttctgca aattaattta caggtaaaga aaaatccaca 1590481 tggcaaacaa atgcttcttg atcaattaga gctctatttg tcagttcctt tttcttttcc 1590541 ggttcttgaa gctgtacaga agagtaattg acgattccaa ggccgatttc cgtccctttt 1590601 gaatccatca gccgaacaac tgaaccgctt ttgaatttcc ctttaatctt ctgtacaccg 1590661 tctaggtata aactcgattg tccgtttgtt atttttcgtg aacaatcatc tgataaaatc 1590721 atttcacctt ccggaccgga attaaaagcg atccattgct ccttttgatt caacggaagc 1590781 gttccttctg cttcaaaata ggtgccttcc gcctgttcat gaacggcgtg gtataaaata 1590841 tcgccagcat ctgcctgacc taggaaacct ttaatgccag acgccattac gattttaaac 1590901 gcatcaagct tagagcgcat gccgccggtg ccaacgatgc ttccagtgtc acctgcgcat 1590961 gcttcgatgt caggtgttat ttcactcacc cgctgtatct ttttcgcttc tggatttgtg 1591021 cgcggattgc cgtcatataa tccgtctata tctgataaaa tcacaagcat atctgcatca 1591081 atcaatcctg cgacttttgc tgcgagcgta tcattgtcgc caaacttgag ccgattgacg 1591141 gtaactgtgt cattttcgtt tatgatcggg atgatgccgc gctcgagcag tacattcatt 1591201 gtattcctga cattgttgta tcgatattca tcagaaaaat cgcttctcgt aattaaaatt 1591261 tgggatgcga catagccgtg tgccaaaaac agctttgaat aagcctccat tagcaatccc 1591321 tggccgattg aagctgatgc ttgtttttct ggaagcttct cgggcctttg gataaatccg 1591381 agcttccgat atcccgccgc cactgcgcct gaggaaacca aaatcacttc ataaccggcg 1591441 tctttgagtt tgacgacctg gtcgaccaac gcttctaatt ttcgaatgct gatttctcca 1591501 tgaaggcttg ttaatgaact gcttccaatc ttcacaacga ctcttttcat gcttgtatca 1591561 ggcgtcactt tatcactcct gatagcggcg ctgcagtttt ttcgatatct tcgctgattt 1591621 cctttgaacg cttagccgca tgctttattg cttgagaaat cgcttctccg ccgccgctct 1591681 ttttcaaggc ttgcagcccc gctgctgtcg ttccgttcgg tgacgtgata ttatctctta 1591741 agatctcagg atgttctcct gtttccatga gcatttttgc ggcacctaaa agtgtctgtg 1591801 cgccgatgct tcgagataac tgtttatcga ggcccgcttc ctcgcctgtc ttttcaatga 1591861 attccattaa ataataaaaa tacgcgggtc cgctgcctgc aattccggtg aatatatcca 1591921 tttgattttc ttggattgta tagacttcgc ccatgcatcc gagcaatgct tcggccagct 1591981 tcttcaggtc ttccgacaca tatttgccaa gggcaatagc tgttgcagaa gcgccaatca 1592041 tactggaagt gttgggcatc actctgacaa ccggctgttc attaagcaat gattgttcaa 1592101 taaaagaggt agttatgccg gcaaggaccg acaatattaa ttgatggggt tgaatacgtg 1592161 attttagtga tgacagagcg ttttcggcgt cttttggctt cattgccaaa atgagcacat 1592221 ccatgtcttc aatacatagt tggttcggca aggcgccttt aatgccatat tgaagttcaa 1592281 gttcagttaa tcgctctgta ttgctgcggt ttgtaacgca gatgttttgt ttcgggattt 1592341 tgttggctcg aacgatacct gatatcattc cttccgccat agatcctgct cctataaagg 1592401 ctactttctt ttgatcaaag atcggtaaca tctcctttgt tcgctttttt gttcgcattt 1592461 tcacacgttt aaaatgttac cacgtgagga aatgatgtca agtttgaagg ccattattga 1592521 tttgtattgt ttcttttcga caaatatgta taatgaaaag cagaaaacac ccggttcaca 1592581 ctgctgcgcc gggtgtttgt ttctattaaa aattatctga gagagctttt tcaatcagtt 1592641 ttttacagcg atccagctct accttcagct gttttttata tagcttggca gcttcgtaat 1592701 ctttaaattg atagaggacg acttcctgga gcttagcccc ttcttttttt actttaattt 1592761 gttttagtat cccgtcatca agaagctcat gcaaagaccg gtatacttct gtatgatttg 1592821 gtttaaaacc aatctcttta aattcagacc gaagtacttc aagcagcttt aacccataga 1592881 gtctctcttg ctctgtcatc gttatcatat aaagcttcaa aaatgcgcgc tgtttcacta 1592941 aaaagcctgt tgaactcctt ttttcttctt tcatcatatg cactccttct tctgtcactg 1593001 acaacactat gtactaaata ttcaattttc ttttattgtt ttccttcttt atattaaaga 1593061 ctgatagtcc agttatttca tgtttactga ttataggtgt agcggaaaaa ataaatttcg 1593121 actgaacatt tggtacatag ttttcttagt tctattatag cctgcattta ctgctatctt 1593181 caatttaaac gattgccagg gtttacatat ctcattttac cggtacggat ttcattcaaa 1593241 taaaaaaacc tgtcgaaaga caggttttca tttttaagga tttgttgacc ataatcccgc 1593301 tgttttgatg aaaatacgag gatctaattt cagttgtgcc accatgtact cagcaagatc 1593361 ctcaggctgc ataacttttt caggattacc gtctgttaag ttcaattcga tagacatatc 1593421 actagcgaca gtgctcggcg ttaacgcgct gactctgata ttatgttttc tcacttcttg 1593481 cataagagac tctgttaacc cgagaacggc aaatttagaa gcgctgtaag cacttgttac 1593541 agcagctcct ctttggcccg ctgtagatga aatattaatg atgtctccgg ctttgcgttc 1593601 gatcatttcc ggaagcaccg cgcgagtgac atggtacaca cccattaggt tgacttgaat 1593661 aatattttcc cactcatcag ctgacagatc taagaaaccg ccaaatttgc tgatgccggc 1593721 attattaatg aggatatcga tatcaccgag ctgttccttc acttgagcta cagcttggtt 1593781 aacctgatcg gcatctttta catctgcagc agcaaatgca gcttttacac caagcgcttt 1593841 gacttcttca gccacttttt ctacattagc ggaagtccgg ccaattaacc cgatattcac 1593901 gccttctttg gcaagcgcca gagcagtagc gcggccaatt cctctgcctc cgcctgtgat 1593961 tagtgcagtt ttatgttgta aactttgcaa ttgaagcacc ctttctttgt ttacatatgt 1594021 acgatatcac attataagta caatacatcc aatacgcaaa tcaaacgaac tgtgtaaata 1594081 tcatttcttc tgattaaaaa aacggataca gggtaatgac ataagaaaag gagtgaacat 1594141 atgattatag tttatatcag tcttgcagta ttagcagttt ctattatctt cttaggagtt 1594201 accgtgatcc aaaacaagaa aaaaatagac cccgcactaa aggagctttc ctctgttacg 1594261 caggctatgc aaaaacaaat cgaaggatta aaaacagaaa cagagctgct gacgcaaaaa 1594321 caaaagaaga ttcagcagga tgtccaaata aaaaaataca cgcttcagca gaccgcagct 1594381 gaagtgaaag aagttcccca agcagtcaaa gaggtgtggc aggcaggaca ttttaatagc 1594441 agataaggat gaatgagatc ccgttgttac gatcagaatg gacaaatggg atctcatttt 1594501 tcgaggaggc ttacacatga ttataaaccg cagctgctta aaagagttcg cagaaaaagt 1594561 acattttctt ccctcttcac ttacaaagtc cgatttactt actgatccat ttcgtctcca 1594621 tcaagaaaac gaacttggca tctactattc acctcataat gaatttatca atcgggatgc 1594681 ctcgcttgtg attgccggga tcacgcctgg tttttcccag atgaagacag cgtacgaaac 1594741 agccgccgaa agcctgctgc aaggcgggac tcttgagcaa atggcagtag acacaaaaat 1594801 agcagcgggt ttctccggat cgatgagaca taaccttatt accatgctgg atttatgcgg 1594861 gctgccgcaa gcttttggca ttcaaagcgc cgcaaagctt tttggagaat tacggcatat 1594921 gctccataca acttccgtta ttaaatatcc tgtctttatc cagcaaaaaa actataccgg 1594981 atacaaaccg gctatcactc attctcctat cctaagcact tatgcttttg ggcacttccc 1595041 tgcagagctt aaccatgtga cgggaccagc tcttctcatt ccgttaggaa aagcggccga 1595101 aacagtgtgt gaaacattga tcagacagca cagcctccag aatttgattt gccttaacgg 1595161 ctttccccat ccatcaggcg cgaacggcca tcgtttgaaa caattcagca aaaacaaaga 1595221 gcaactagaa agacaaattc gttcctttgc tgcattggtt gatttcgcta tagaaaagag 1595281 gaaataaaag ggatatgata aacaaaaaca caaacgtggg gagtggttga atgtttccta 1595341 tattagaaac ggatcggctt atacttaggc aaatcacaga tcaggatgcg gaagccattt 1595401 ttgcttgttt ctcaaacgat gaggtgacac gctattatgg gcttgaaaac atggaatcta 1595461 tagaacaggc catttcaatg attcaaacgt ttgctgccct ctatcaagaa aaacgcggta 1595521 tacggtgggg aattgaaaga cgggacacta aagaactgat cggaacaatt ggctttcacg 1595581 ctctggccca aaagcatagg cgcgcggaaa tcggttatga aatcatcccg gagcattggc 1595641 gaaacggatt tgcatcagaa gtcatttcaa aggtcgtatc ttacggattt tctgcccttg 1595701 gactgtcgcg tattggcgca gttgtattta ccgataatga agcatcaaat cgtctgcttc 1595761 taaaaatggg gtttcaaaaa gaaggcgttt taagacagta catgtatcaa aatgggactc 1595821 catatgatac aaatgtgtac tctattgtga aaccaagaga atgacggtat tctcttggtc 1595881 tgtgccacat cccttttcct ttaaaaagat aaaaagcgcc cctcaaacag ggcgctttct 1595941 aattaagatg catattgagg agatgtttcc tccttaactg ctttttcctc aggtatatga 1596001 atacattttg tcaagaccgc acttgcaagg taaagggccg caaagatcca gacgacacct 1596061 tgcgcgccga cgagaccgat gaacagccaa gcgagtgcag ggccgacaaa cgctgataaa 1596121 cctgcagcta aattcaatac agacatggct gcccctttat cttttcctgc caccgtcggc 1596181 acaattgcac caatcggcac atagcctgcc agcaaaccgc cccaaataaa gccgatcacg 1596241 ctgacaaccg ctaaacttcc gccggagaaa acaggtgcgt agtataataa gacggtgaaa 1596301 atgccgcagc cgactccgcc gaaccaaata acagtatttt tccagccgaa tttatcgccg 1596361 acaataccga agataaggtt aaacacaatg ttccccagga aaatcgttcc ccaaatttgc 1596421 agccacacat tggttgaaat tccatgctgg gccatgtgca tcggcaaaaa gactggaaaa 1596481 ccatatgtac caatgctgtt gatgattctg atgattccgc ctgtaagcac gcgcggattt 1596541 gtaaatagaa tcgtaacccc ttttaaaagc tcctcggctg tttctgatct ttttcttttc 1596601 ttcttttcaa aacggtcttt attgataaac aatgcaaaga atgcaccgag acatacccag 1596661 aaaatagagc tccaaagcgt attcaaataa ccgaacgctt tgatcgcgta gcttgagtac 1596721 caagcgccga acacaaacat gccgaggcaa tatgcaatcc aaaaccagcc gacagcagtg 1596781 ctcagtttgc tttgcggtgt tctgtaaatg acccatgtca agaaagaata agcaaaaagc 1596841 gggtaaccta acccttttac gaagtaagtc acatacatca ctggcaggtt cagctgttca 1596901 aatccaaata cgataaaagc agctgtaccg atcacataaa acaacagccc cataaacatc 1596961 gttcgttttg cgccaaatgc ttcgagacat acacccgaaa accaggaagc tatggcaagc 1597021 gcaattccgt atatactaaa aatggaagcg gactgctgaa cggtgagccc gttttcgatc 1597081 aaaaaaggac tgagccagcc ttgttcaagg ccatctccca tcataaacaa aacaacccct 1597141 aaaaatcccc aggcaagccg cttcggtatt cctattttat ccaacatatc tgtctcctcc 1597201 ttagatgcta ttattcatta ccgtattacc ttattaaagt tgaaaattaa atgattcctc 1597261 aaaacagcag aaattccgtc ttaaattaat actttgcttt ctgatcctga aaaaaagcgc 1597321 tgtgtttgct tccattcctc atataaagcc aattctatct gacagtcctt cggttcgatc 1597381 acccggacat ttgctgacat ctcctccgtt aattgaaagg tttcattgca aatgactgca 1597441 gcaccgacga cagatgcctg atgatatccc tcttggacat agaccttttt ttgaagaaga 1597501 tccgcgatat attgagtgag cgctttgctt tggaatcccc ctccgcacac ccaaacataa 1597561 tcacgttcaa acggagtaac ctctgttaaa atgtcaaagt tccatttgat tgaaaatgcg 1597621 atctcttcta gcgctgcacg tacaaaatgt gccctcttta aatgtgctga cagcggggca 1597681 tcaaaaagaa aaccgcctct cgttaacgca ttcttttcag ccgataaata agagccgaga 1597741 gccgctacac atgcatggtc ttcttttgca agtgcagaaa tctcctcctc cattacttcg 1597801 tacgtttcat tcggataaaa aatctgtttt aatttttgat aattcaagcc ggtaattccc 1597861 ggattcgttt ccacaagcca atgcccttga tccgtatgac agttcaacca ggctttatgt 1597921 tttgtgtcgc catgatcctc agtaattttg gttattggcg ttgttgtccc tgatacaatg 1597981 acaatgtcct caagtccagc tccggtgctt ttgacagcca gctgtgtatc cccgccccct 1598041 gctataacct tagcatttat tgaaaggcct aattcggatg catattcatt tgctatcgtt 1598101 ccaattgctg ttcccgctct tacaagaggc ggaaggatag atggagaaaa gccgaaaatg 1598161 tcgcacatct cttctgacca agtgttttgc ttcacatcaa atagcagggt ttctgttgcc 1598221 tgtgatggtt catatgttaa tattccgctc agttggtacg tcacccaatc actgatgctt 1598281 gtaaagcttg cagtcttttc ccataaagag ggctggcgct gttttaatcc ataaagcttg 1598341 agcgcagaaa aaagtgcagt tggcaggcgg cctgtgctgc tgtatatctc ttcccaatcg 1598401 ggaatgcccg cctcccactc tcggccgcga ttatcgatgt tcggcagccc gagaaaagga 1598461 ttgccgtttt gatcaatcaa aacaatcccc tgtctttggc tcgtcgatgt caaaccaatg 1598521 atgtcaatat cacacgaacg ggatagcgca cgttttgcca aattcatcac ctgcttccac 1598581 agcacctgag gagaaaaata acggctgtcc gggtaaagcg tctctgtgga atactcgatg 1598641 tcctcccgtt caactgttag aacactgcca gttacactca cgaccgctac cctcgcattg 1598701 cctgtgccaa tatcaaaaac gagatagcct ttttgttttt tcattctgtt agcctccttt 1598761 cttatccccc tgttttcagt gcgtccttgt tatacattgt ctgaatatta agagtttttt 1598821 cacccttcca ctttttgagg gctttattca gtatcgtcac gtgatgatcc tccacttcaa 1598881 atgttgctcc agcgagatgc ggtgttgcca gaacattagg caatgaaatc aattcataat 1598941 ctgattcctc tggaggttca tgataaaaaa cgtctagtat cgcaccgctg attttatgtt 1599001 cttttaatac aaataaaaga tcttcacggt ttacaacaac tgctcttgaa gtattaacga 1599061 aaatcgcact ctctttcatc agatcaaaat attgccgatc tatcagtccg agtgtttcct 1599121 cagtgcgagg cagatggaca gaaacgatat cgctgtctga aaacaccgtt ttaagagatg 1599181 ctttttcata caacggatga tcgtcttgaa tgtatggatc gtaatatttt atcttacagt 1599241 caaacgcagt cagcagtttt gcaatccttt gcccgactgc gccgaaccca atcatgccaa 1599301 ccgtttttcc tgttagctca tttcctttaa atttgacata agcctgcagg taatcactgt 1599361 cccactctcc atccttcagc cactgattcg aggcgctggt atggcgcaga aaggaaatca 1599421 catttccaat aaacatttcg gcaacggctt gtgcattccg ccctggtgta taaaaaacag 1599481 gtatgcccct ttttgaggca gctgccacat ccacatttga gggcattccc ctgcaaacac 1599541 cgacaaatga aagttcggga acagaagcaa atacgctgtc tgttacctga tcaagttcag 1599601 taatcaagcc tgtcgcattt gttgctttta gcagctgaat gagttcatcc tcccgatatg 1599661 ccctaccttg ttccttccaa gattgataag caactgagcc aaacaagttt tcaagctctt 1599721 ttcgtccttc ttcgttgtac ggtgctgtaa ccaaaaccgt catgctgcaa aacatccttt 1599781 tcatcgtatt tttcataaaa aaaatctctt tccgaagatg gaaagagatt catatatagg 1599841 cgcgctctgt tacaggcaga cgccggtata aaccttgctt tcctatcttt caagctagcg 1599901 cttgctggaa ttggcacaat aatgttgccg aggtttcata gggccagtcc ctccacctct 1599961 ctggatagaa aatattgagt atgtaatttt cagaatgaag aatacgttta tcataaagaa 1600021 gactcagatt gatgtcaatc tctttttttc agaattgacg ttatcatcgg aaatgttata 1600081 attcttacaa aatatctaac tagagagagg aactgggcca tgagatcttt tgccacacaa 1600141 caaaacggca ttttcaaatc cgtttgctcg ctggactgcc cggatcagtg cggattgtta 1600201 atacataaaa aagacgggaa aatcgtaaaa gtgcaaggag accctgatca tcctgtcaca 1600261 gctggaaaca tatgcaacaa agtccggaat atgacggagc gcatctatga tgaaaagcgg 1600321 ctgactacac cgctcaaacg aacaggtgcg aaaggccaag cgatatttga accgatttcc 1600381 tggaaagagg caatcgatac gatcacctcc cgctggaaac agctgattga tgaagaggga 1600441 gctgaaagca tacttcctta cagcttttac ggaaatatgg ggaaattgac agctgaagga 1600501 atggaccgcc gcttttttta ccgcatgggg tcaagccagc ttgaacggac gatttgcagc 1600561 aaagcgggat ctgaaggcta taaatataca atgggcataa gcgcgggaat cgatcctgag 1600621 gaaaccgttc atacaaaact atttattttt tggggaatca acgcggtcag cacaaatatg 1600681 caccaaatta cgatcgccca aaaagcgcga aaaaaaggtg ccaaaattgt cgtgatcgat 1600741 gtgcataaaa atcaaacagg acgtcttgca gattggttta tcccaataaa accgggaacc 1600801 gacagtgcac ttgctcttgg catcatgcac attttattta aagaaaacct tcatgatgaa 1600861 gcatttctgt ccgagtacac ggttggctat gaagagctcc gtgaacacgt gaaacaatat 1600921 gatcctgaaa aggtatcgac gatcaccggt gtcagtaccg aagatattta ccgactggca 1600981 aaaatgtacg gggaaacctc cccttctttt atcagaatcg gaaacggacc ccagcatcac 1601041 gataacgggg ggatgattgt aaggacgatt gcctgtcttc cggcgatcac cggccaatgg 1601101 ctgcacacag ggggcggcgc aattaagcat aacagcggaa ttttagaata taacacaaat 1601161 gccttgcagc ggcccgactt attgaaaggg cgcaccccga ggtcgtttaa tatgaatcag 1601221 cttggcaggg tgcttttgga aacagacccg ccgattcgct ctctatttat ttacggaacg 1601281 aaccctgccg tcgtcgcgcc cgaagcaaac aaagtcagac agggcttgct gcgggaagac 1601341 ttgtttactg tggttcatga tttgttttta acggaaacgg ctgcatatgc ggacattgta 1601401 ctgcctgcaa catccgcttt tgaaaatact gatttttaca cctcctactg gcaccattac 1601461 attcagcttc agcagccggt gattgagaga tatggggaaa gcaagtctaa cactgaggtt 1601521 ttccgattac tggctgaagc catgggattc acagaccagg agcttaaaga ttcagatgaa 1601581 gtattaatcc gccaggcgct tgaccatcca gataatccgc atttggcaga gattgattac 1601641 gattcactta ctaagcattc atttatgaaa gcgaaacgtg aaaagccgct gtttccgggc 1601701 gaacttccaa cgccaagcgg aaaaatagaa ttatattcag aaaaaatgaa acaagacggc 1601761 ttccctgctt taccgacata tacacctctt gtaaccgata atgaacatcc gtttatgtat 1601821 gttccggggc caaaccataa tttcttaaac tcaacatttt ccaataatga aaaacacatc 1601881 aagcttgaaa agacgccaaa gctctttatc aacacaaaag atgctgaaaa acacggaatc 1601941 gttgatgggg cacctgtacg aatttggaac agccggggag aatgcgagct gaccgctgca 1602001 gttggagaac aagtgctgcc aggtgtcgtt gtcagccaag gattatgggc ggatgaacaa 1602061 ggaaaaaaac agcttgtaaa cgcgctaacc ccagatcgct tgtccgatat gggcggcggc 1602121 gccacctttt tttcaggccg tgtacagatt gaaaaggttt gaaaaataat gaaacccgga 1602181 gtatgccaag cccgtataac ataacatcga cataatggag gcatacacat ggacgttttt 1602241 ttaggaattg gtattgcttt ggctggatat tttatcggtg aaggcttaaa gcagaggaac 1602301 caaaccaaag gtaatgaaca aaatgatatc ttcctaataa aagaacggga tatttacttt 1602361 tacattggac tttttttagg aataacaacg actgaagcaa aacagttagc tggagacatg 1602421 gcagacctgc cttacatcga aataaacgga aaaaaatatg tccagaaaca tatgttaaaa 1602481 gattggacat tcacattagt tgaaaaacat cagggtgaat aaaacaaatc tgaggagagc 1602541 gagattcatt gtcacgctct cctctgttta gctgtatgga tcctgccacc aaaactttgt 1602601 gctataagcg ctgataaaac gataaaccac catctatgtt ctttcctcaa acaactcaag 1602661 atgcccgttc cacaacaata gtttttatat tcctttgatg acgtgatgtt cttgatgaac 1602721 gtatgtatcg taaaacactt agaaaaccta ttcggtttga atgtgtgctc tcattatgcc 1602781 cccatactgc gcctttatcc gcggaggatt tttttaaaaa aatatgaaac ctaaagcttt 1602841 tagatcctga atttttattg aacctccata tttctccgat tggtaaaaat tagcctatac 1602901 accggaagct gtacgtttat aaaggatcag agaatcccat aaccagtaaa tcactgcagc 1602961 cgcaatactt aacatataat aaaagtacga ttgcaatgtc catgctattg acgcaggttc 1603021 attgataaca aaaaacagga aagctgcgat aaaagcaacc acactgtaaa tcaataggta 1603081 catgacattg aaagttctcg cttttttctg caacttcatt tggagcggaa cagcaaaaag 1603141 gccatacacc acaaaaccgt ataataaagc aattgctgcc gtaaacaatg caattatcat 1603201 atcgccatac ataacgaaag aataaaaccc taataacaaa ccaaatgtaa ggctggatag 1603261 ccctaatgtc attaaataat atgatgcgat ttttttcatt ttttcacccc ccttgtttga 1603321 tttattcaca gtgctgttag tataaattca caacctttgt atttctttta tcgagatgtc 1603381 ttccctaacg tgctatacgc aatgcgctaa taaaaggttt caaaaatgac gttcttttat 1603441 tagataatac gctggctgaa aacgcctctc ctgattggcc aaagcgcgaa tgaaaaaagt 1603501 gcatgaatac ctgcccaaca gacagaataa gaagagttga tatttcaaca cttttcgtaa 1603561 aggggtgaaa ccaatgagta agaaaggtat tcaaaattca agtattgaac aaataagaaa 1603621 tgaccatgag actgaaacag cttttaaagc agatgatcct aaaaaacacg gttccgatcc 1603681 taaaagaacg aaataagttc ttacccccac taaaatatca ataatctgga ggaagtaaag 1603741 tgactcaaaa aaacggtgca gacagacctg atgattataa aagattttct tcattagaca 1603801 aggaatatga ttttcagcaa tctatacgca gcaatactga gacagaaagt gtaaacactg 1603861 aaacacaaac tcataacaaa gaaaacaaaa atgacacaac agatgttgcc gggaaatact 1603921 ttgagccctc agattataaa ggaagcacgc aattagaaaa aggattggct gaaactcatg 1603981 aacaggtcag cgatgactat tttgaaggga caatcgatca aaatttggac tagccataca 1604041 aacggaacta acttaaaaga agtcagttaa ctctgttttt agaaacaacc acagtaaaag 1604101 tagccaaccc ccaccgaata agatgggggt tgcacgtaag tagcctgttt aatatttaaa 1604161 acgattaatg acggtttgaa gttcttctgc caactgagat agagattctg cggcatagga 1604221 gatttccccc attgaatgaa gctgttcctg tgatgaattt gcaaccgctt ctgtatttgc 1604281 tgacgtttct tttgtaccag cagccaatgt atgaactgtg tgctgaatca cttcaacgcc 1604341 tgaagtaagc tgttgagttg ctgctgcaac ttcttgtatt tgagaagtga cctgttccac 1604401 caggttcagt atttcattga aatttcctgt tgtctcttga gaaagaacaa tacctgagct 1604461 cacattttct tgaacaactt taatattatt taccgtttct atcgattcgt tttggatggt 1604521 cgctaccacc gattggatgt ggtttgcaga tttatttgtt tcatccgcca acttccgaac 1604581 ttcttctgcc accacagcaa atccttttcc ttgctctccg gctctggccg cctcgatcgc 1604641 tgcatttagt gccaacaaat ttgtctgctc tgaaatcgtc gtgataagcg aagagatatc 1604701 gctgatttct gctgtgctcg ctaccaatgt ttgcaatcca ttgccggctg aatctacaga 1604761 tttatcaatg aatttcatct ggtctaacat cttgttgacg gacttagagc ctatttcagc 1604821 cttgtctctc atcgaagaag aaagatccgc tatgttccct gtatttgaag cgactgatga 1604881 tatactgtct aataattcag tgatggattc tgcgctcttt tctgtcattg agctttgctt 1604941 cacattgctg tcggcagcca tctgcatggc tcgtgaaata tgttcagatg ttgatttcga 1605001 ttcttccgcg cttgccgata attcttcaga ggaagcggcg acttgttcag atgagctgct 1605061 gatctgcttc acaatttgag ttaatgaatg agtaaaagaa ttaaaagatt gggcaagctg 1605121 gccaaattca tctttatttt tcacaatgac ttttttggtt aaatcagcct cgccgtgtgc 1605181 aatttcctcc agctgcttat ttatgcttct tagtggcacc ataatggact ttaacagcat 1605241 tatgcttaga acaatgccta atattactga tatccctgtg acaatgataa tgagcgattg 1605301 actcattttc ccattgccct gtatttcatc ctttagatcc tctacctctt gatccaggcg 1605361 atcagacagc ttattgacag ccggagctac gccttctttt cttattgttc tttcttctcc 1605421 aaaatggatg gtttctgctt ttttaggatt tgaagagtag gctgttacta cttgctgatt 1605481 caaagctcta tactgagtaa aacttgtctt aatgtcttca atattggatt gatacttctc 1605541 ttcatcaatc aagtcattaa cccggtcaag gctctttaag acatcgtctg cttttccctt 1605601 cataccctcg tcgtattctt tgtctctggt aatcaagaag cctctttcat catttgataa 1605661 cccggtcaat tcatattgga tgtgttttat ctctttttgg aattccattt tgtctttaag 1605721 ttcttcattc tttttcacag tagaagaaat cataaatact gaggagcctc caattccaat 1605781 aattgaaaca actaatattg atataatccc cagcaatttt gttttcactt tcatgtgtcg 1605841 ttttcccttt ccgcacaatg taatggctga aataaaatat gttcaagcgc gtttgaatcc 1605901 aattcgctta cgctcatgtc cataatatcg acacgtgtta tcaagtttta tagtgatatt 1605961 cttatatgaa taagcaaatt ctttacgtct ctgaacttac agaaaaacct taagtaaaat 1606021 ttgcagtctt ttgcggtatg taagtcactc ttattcgttt ttctaaaaaa ggcttttccc 1606081 acctcaaatt ggctgaaccg gctgttttct cgaaaatata atacaatacg cagcataata 1606141 tgaaggagcg aaacttaaat ggggatcatc aatggtaaag aattcattga ccgattgaat 1606201 aaactagaaa acgaaatatg gtatgatggc gaaaaaataa agggtaacat ttctgagcat 1606261 cctgcattta aaggaataat caaaacaaaa agctcacttt atgaattgca aacaaaggat 1606321 gagttaatac atgaaatgac ttattgcctt cctggagatc ataatcgaat cggcctttcc 1606381 tatctccagc ctaaaacaaa aaatgatttg aaaaaaagaa ggaccatgat tgaacattgg 1606441 gctagacata ctcatggaat gatggggaga agtccggatt acatgaatac ggttatgatg 1606501 agctttgctt cgtcagcgga gcttctaaaa gataaagaga attgctttcc tgaacatata 1606561 ctagatatgt atgaacaagc tgctaagcat gacctttcct ttacccatac attcattact 1606621 ccgcaagtga accggtcaca gtcctatttt gggctaagtg aaaaaccgat atctgctaaa 1606681 gtcattgata gaaccgaaaa aggtttaatg attcatggcg cacgactgct tgccacacaa 1606741 ggcgggttga ccgatgaaat cttggttttt tcagcgccta aatttttctt tgaaacagat 1606801 gaagcttatg ctttttcaat cccttctaat acaaaaggcg taaaattcat cacaagagaa 1606861 tcatttgtat taagcgactc ttcctttaat catcccttaa gctcaaggta tgaagaaatg 1606921 gattcaattg tggtttttga tcatgtgtta gtgccgtgga atcgtgtgtt tttttacgat 1606981 aatgtggaag cagctaaaga ttttatgaca aaaagctctt ttcatgcctt tacctttcac 1607041 caggttgtca ttaggcaaat gataaaaatt gaatttctat taggtgttgc acagcttctt 1607101 gtcgacacca ttaatgtttc cgaatatcag cacatccaag aaaagctctc agaaatcatt 1607161 gtgggattgg aaacaatcaa agccctcatt gacaaatcgg aaaatgatgc tcagttagat 1607221 gaattcggct atatgcgccc ctgtttaatt cctcttcaag tcatcagtac gatcattcct 1607281 aagctatatc ctcgatttac tgaaatcata caattaattg gagctagcgg aatggtgaca 1607341 ctgcctaccg aaaatgcatt tgactcagag atacgggaag atcttgacca atatcttcaa 1607401 gcaaccaata caaatgctga agaacgtgtg aaaattttcc gtttggcatg ggatttaaca 1607461 atgagttcat tcggaactag acaaactcac tacgaaagat attttttcgg agatcctatt 1607521 cggatttcaa gcaggctgta taccagttat ccaaagcagg agcagttgaa catgattaaa 1607581 acatttttac atgcagatac agaacattga aaaaacagcg ggaaaagatc cgctgtttcg 1607641 tattttttat tcaggaaact gaacatggcc cggtactgta taggctttgg acgttccgct 1607701 ttcaggcagc tttggaatgg tgtctttcac aacttttccg cggatgtcag tcattctgac 1607761 tttgagagag ccagtaccta aattcgtact cacaaaatgg ttatagtcca ttttctccat 1607821 gttgatccac ttaccatcct tttcatattc cattttcata acaggatact tgtgatttct 1607881 gacttggatt gctgcccacc acctgctgct gccttctttg atccggtacg tgaaattgcc 1607941 ggtgattggg gctttgacaa cacgccattt aatattgatt tttccgtctt tcatattgcc 1608001 gattttacgg aaggcattag gtgacagatc aagagctccc cgagcgcctt cgggataaag 1608061 atcagtaaca tatacggttg ttttcccttt tggcccttca acttccaaat aagagccggc 1608121 aagtgccgct tttactcctc cgtaattgag atccgccgga tttattgcag taatctccat 1608181 atcggaagga atgggatcca gcaggaaagc tcctcctgaa tagcctgacc ctgtatacgt 1608241 tgcataacct tcatgcaggt cgtcatatgc tgccgaagct tgcggggaaa aacagaagat 1608301 cgtcaacaaa accataccaa caaatgcact catgatcttt ttcatatttg gtcctcctca 1608361 aaccagactt caaatgagaa tcattatcat tataagactc aatccatctg gtttgaaaga 1608421 ggaaatagat tcatagttga ttttaaggca aattcactat cattcatata tcaaatgtag 1608481 gtacttatga aaaagccaat acaaatgaac gaatgtgcac ttcagccgaa tgtcttattt 1608541 ttccctctca aaattcgcat ttcaataacg aaatgaaaca ggctgttggc ctgataacag 1608601 ctatacagga aaagctattt ttccccgctc agtttcaact tagctgtcat catgatgcca 1608661 aagatcagca caatcggaac ccaaataatg aagtgataaa aatcaggctc agccagagca 1608721 acaataatag cccctacaca atacaaaata atagccagtg ctcttaacac agtatctctt 1608781 aagaaagtct tcttttgctt cttaaaaaac aaacggccgg atatatcctc taaaagagaa 1608841 gccaaagtgc cggtcaacac agttgaagaa atacctgcaa tccccagttt ttttgctgct 1608901 gtagtttgaa tccccataga aatgctcatg agtataatta gaatgtgcac aggaacaaat 1608961 gcccggtaaa aagaaagaca agcaaagaca aacaaaatga atgcttcaag tgcgagggct 1609021 tttgtcacag cagaaggcca aagggtattt tccgcctttc cgaccatcaa tgtagcaatg 1609081 atcacgccgc atataaatcc gattagcgca gtcaaggaat taaaaacagt gacctgaatg 1609141 gatttgccga tagctaaccc caataataca atgtttccag tcatattagc tgtgaacaca 1609201 tgtcccaggc ttaaataccc gattacatcc acgattccag ctgttaaaca taaaagtgat 1609261 agcaaggtgt ttcgataagc tgctgcagtc aacggtgtat caatcctttc ttctatttca 1609321 attgttagta tgtcttttgg cgcaatctct attttttaag taacccaaca ttaattagga 1609381 agatagaacc tattattcct ttccattaac tgtaataata atccccgcaa ggaaatgatt 1609441 aaaattgaaa ggaagcatat tgtgatgaaa cgactttgtt tatggttcac cgtctttagc 1609501 ttgtttttgg ttctcttgcc tggaaaagca ttaggtgcag tcgattttcc gaatacctca 1609561 acaaatggcc ttttaggttt tgccggaaat gccaaaaatg aaaaaggcat ctctaaaacg 1609621 ggcacaacgg gtggaaaaaa cgggcagatt gtttacattc aaagcgtaaa tgatttaaaa 1609681 acccatctag gaggatccac tccgaaaatt ttagtgcttc aaaatgatct ttccgcatct 1609741 gcgaaaacaa cagttaccat tggctcaaat aaaacactcg tgggctctta cgcgaaaaaa 1609801 acgctgaaaa atatttattt aacaacttca tcagcttttg gaaatgtcat ttttcaaaat 1609861 ttaacgtttg aacacagtcc gcagattaac ggaaataatg atatccagct ttatttagat 1609921 tccggtatga actattggat tgatcacgtc acattctcag gtcatagcta taatgcaagc 1609981 ggaagcgatt tggacaaact cgtgtatatc ggaaaatccg cagattatat cacgatcagc 1610041 aactcaaaat ttgcgaatca taaatacggt ttgattttag gatacccgga tgattctcag 1610101 catcaatatg acggctaccc ccacatgaca atcgccaata attattttga gaacttgtat 1610161 gttagaggcc caggtctgat gagatacggt tactttcatg ttaaaaacaa ttacagcaat 1610221 aattttaacc aggcgattac aattgctaca aaagcaaaaa tatattccga atataattac 1610281 tttgggaaag gcagtgaaaa aggcggcatc cttgacgaca agggcactgg ttatttcaaa 1610341 gacataggca gctatccatc actcaacaag caaacctctc cgctgacttc ttggaatcct 1610401 gggtcaaact atagctatcg tgtccaaacg ccggaatata caaaagaatt tgtcacgaaa 1610461 tatgccggat cacaaagtac aactctggta tttggctact gatataaaag aggccctgcg 1610521 ttaaaaacgc tgtgcctctt tttatactat aggctatttt taagcgatcc ttgtaattcc 1610581 atcaagatcc agcgtcggtc aaactaaaaa gcatatgttc ttttccacaa taacttctta 1610641 actggctttc ttattatacc agtttatcgc aagtgaaaag aaatcattgt tctgaacctg 1610701 tattaaatga acgatcgtcc cacaaactac ttaaaaaccc ctaaaaagga tgatggatat 1610761 gtgcggcagg tttactttgt actctgcatt tgatgatatt attgaccagt ttgacatcga 1610821 tcaatttttt cctaaaggtg aataccagcc aagctataat gtcgcaccat cacaaaacat 1610881 ccttgcaatc atcaatgatg gatcaaataa tcgcttaggc aagcttagat ggggacttat 1610941 tccaccttgg gcaaaagatg aaaagatcgg ttataaaatg atcaatgctc gagccgaaac 1611001 aattaccgag aaaccggcct ttcgaagacc gcttgtcagc aaacgctgca tcataccagc 1611061 agacagtttt tatgaatgga aacggcttga ttccaaaacc aaaatcccaa tgcggatcaa 1611121 attgaaatca tctgctcttt ttgcgtttgc tggcttatat gaaaagtgga gcacacatca 1611181 aggataccct ctttatacct gcaccatcat aacaactgag cctaatgagt tcatgaaaga 1611241 tatacacgac cgaatgccgg ttatattggc ccatgatcat gaaaaggagt ggcttaaccc 1611301 caaaaataca agccctgatt atctgcaaag tttgctgctg ccttatgatg ctgatgacat 1611361 ggaagcatac caggtttcat cattagtaaa ttcacccaaa aataattcag ctgagcttct 1611421 tgatgcagaa aatcatatgt agtgattgaa aaaattctct agcaagaact tgtcaaatag 1611481 ctttgttcct taggtgccaa tccctctagt aattatgaat atttagtaca tagatcaatt 1611541 agttatcttt agcatcagtt tgaaataatt ttattatgta aacttaaata agcaatgtta 1611601 ttcctttcat ataaaatagt ttacattttt ataaaatcgc ttcacttttc tattttgtca 1611661 gcaaaaaaac tgaaccacat taaacttatg aaacctgccg cacctgtgga ttgcaaatat 1611721 gatataagcc catagaggta aatccataca ctttccctcc taagaattaa atgaaatttc 1611781 tttcatctta catgaaggtc ttctttcttt tgtttatcca gtgtaatact taataatatg 1611841 ttgatgaatg cagctggaaa atatataaat cccactccaa gaatgcctag tatcgtactt 1611901 aaacttacta tgtaattctt tgtcatcgtt tgactgtcaa tcaatattag aagtgaaatc 1611961 aatccagcta aaacacctat aaaccaagca tcgccaacag cataagaatc atccagcatc 1612021 cctaaccatc gccccaatat agagctccca atggcagtca aactggataa aaatatgagt 1612081 gctttcattt cttctcctcc tttaaagcca atcaaactgg tagaaatcgg ccattgaatc 1612141 cccattatcg aatggttacc atttcatttc cacattaaca ttttaaagct cattacaata 1612201 cgattcaagc agaaaaaccc tacataacgt atatataggg atttaataaa acacaggcca 1612261 aaattcagct ctatctactt taaaaagata tgaagggcag ctgtgtgatc tgttacgtct 1612321 ttacgtaccg ggatatttca caacaggcac tttcttcttg cgcagagaat caagcatgac 1612381 tgatccagca ttcaagttgc tttgtactaa ttctttaggc gtcaatgcca tccactgatt 1612441 gagtgacaca tctgcatagc ggttactttt gaacatttct aaaaaccata atgtttctgt 1612501 accagtgttt tgtatatagt gtccggcatt agaaggcacg tatccaacgt cgcctgctct 1612561 ataatcaaat gtgcgggcag tcccatttcc gataaatacc gtcattcgtc cctgtcctgt 1612621 tagataatat tgccactcat cgctattggg atgccaatga agctctctca tcgcgccagg 1612681 ctcaatctga acaagtgcag cggctatcgt ttttgaaatt gggaagttag aagaatccac 1612741 aattcgtaca ctcccccctg gcatttgaat tgggggttga tttaacagct cgtgtttaaa 1612801 ggtcatgggg acttttccat atggtgactg aatgtcttca ctggcgactg atcccggcac 1612861 attcccttgg tagatataga cttgctcaga cggaagagag ttgaaagcat tctccgggac 1612921 accgaaattt gcagacagaa catcttttgg tgtgtgtgca agccaatctg aaatggttaa 1612981 cgttgaaaac tcagaaaagt tcccatcatc gaaaacgagc agaaactcgc agtgttccaa 1613041 tccctgtatg gaatgcggaa ttcctgccgg gaagtaccaa aggtcgccgg gaccaacatc 1613101 agcaatgaaa tttcgtccgt cttggtcaac agcggtgata cgtgcccgtc ccaaaagcat 1613161 ataagcccac tccgcttgct tatgccaatg aagctcgcgg acgcctcccg cagttaagct 1613221 catgtttaca cctgcaatcg cagtcgaaat cggaagctgt cttacggtga tttctcttga 1613281 ccagccgccg tgatctaatt tcatgggagc gtctgagaat gaaaatctca agttaggaat 1613341 cataccctca tctgtaacag gcggaacaaa tatattcgga ttttgaatat cccgtattat 1613401 atttcgcggg cctgtatcaa tagctccagc tccatcactt cgaataggct gcggcacgtt 1613461 tctgtcttca tgattgattg gttgttgttc caacagcatg cacctcgttt tagaaatgaa 1613521 caagatttta tttcagccta tgcagaatct tagattgctg tgcctaggaa tccgcaaata 1613581 aaaaagtgac caccaatgtg atcacaaata catcaaataa actatttttt ataccatggc 1613641 ttcttatgta atttgattgc ttctgtctgt tttttctggc ctgtcctcca ctccactttt 1613701 actaatacat catgacctat cacttcatct tcaggcatat aatcaaaggt ggaaatatgg 1613761 tcctccatgc gtcccccacc cggcatttca tcacctgtgt actccgataa gtcgtactca 1613821 tctacgttat catcttgata cttttcgcca tctacataca gagtaattct ttcaacaaca 1613881 gtccactttt cttccttctt actcccctgc caatatagat ttagaaaata attgggtcca 1613941 attgaagttt tgtctgattt ttcaaggtta gacatccaca gtccgctttt cccgctgccc 1614001 tcatatttca ctttgttccc tgacaccatt acaaataatg tgatgatgca gatgatcaag 1614061 aatccagcaa tgatcaatag ccatttctta atattgttct tttttctcat gtttttcctc 1614121 actttcctaa ctttttagta ggaaaatacg atcaaaatgt taccgaaaag aaaataagaa 1614181 agggctaatg atctaacaga tgactgtcta aacttttgac ttaaattaaa gtgctttcta 1614241 aagacaagat taaaacgtat aacagctctt aaatgcattt tttgtttcat tgagtcaaga 1614301 accttaaaat ggctttttat tattaaaaat caagctagtg tattaagtaa cttttcaaat 1614361 ttatttatac tcatgatctc gtgagtcaca aatctcccat caaaaaaaac gctaaaagtt 1614421 gtccaaatag ctggtgactt ttgtgcctct tctttcgatg ataactgaat tgactgaaat 1614481 tgaacccctt tcttttcagt caattcccgc aaatcattta tcatgcccac tgcaaacgga 1614541 cactgagctg tatagtatat cgtaatcccc ttttcattga tagaatcact tttcacctgg 1614601 ctcttaaatg caggagaatc tgcaaggcca ttccaagtca aagccattaa ttgaaaataa 1614661 ggggcagctt catcttgtag agtaaacccc atatgctcaa agaaatgctt atcacttaaa 1614721 tagggcagtt ttttcttgcc tgcgatatgg ataatgccat ccatgccgca cgctttcgca 1614781 tctgctatac atttgtccaa caatcgtttc gcatgaccgt tatttttata tctgccagac 1614841 acccacagac aattaatgta cataaaatta ggcgcattga taggcaccca tgcctcattc 1614901 gcaggtaggt attcaataaa gacttttgcc cgttcatgta agcgatagaa caccaatcct 1614961 tcatccattc gagctttgag ccatctcttc ttttcattaa ctgcatgctc atattgtttc 1615021 gtgcttaatg cacagcaaat atgattgtct tcaatattgt cctttgtgat ttcaatgtag 1615081 cacatctcct ctttcccccc tttaacataa ttacatggaa ttcaacttca cactttacat 1615141 gcctaataga ataaataccc gttccaactt aaatactttt tcttttccat tttgccaatt 1615201 aactgtaaaa cccttctttt attcagatat tatcttgatt cctatatcac ccatttcaaa 1615261 tccaaagtgt gttcatcttt gaggattaga tgcactgctt atgctataaa tacagtacac 1615321 gaagtttttt atttgaagta atatttgtta cgggacagca atagtaaata agtgataaaa 1615381 ggggaattaa acttggtgga aaaatgttat tcttgtttaa tttgcggata caaaggatta 1615441 attcaaaatc ctttgtataa aggcgagtat caaaaaacgt ttgacatttg tccatgttgc 1615501 ggttttgaat ttggctacag tgaggatcat gatgtgaggt taggttttat tgtaactcct 1615561 gatcatttaa ttgaggctgc atttcaattg tatcgcaaac aatggcttga gagcgggatg 1615621 gtaattgctc atccggaaga tattccagaa gaattgaaaa atggcaattg cttaaaattt 1615681 gaagttttgt tgaaacaatt gaaaaaacta aatcttgaca tagaaaattt tgaaattagc 1615741 ggtttttaat gatgaaacag gttgcacttg tttaggtttc actgtcatta tcagtaaaat 1615801 gttaagttga aatgcgcaat cagtcacaaa gtctctattc gtattcaata aagactttgt 1615861 gatcatcgac aaacatttca ctcccatcgg ataaagtatc caaaaggcct cctctggttc 1615921 ttctctatag tcattaatca cagtcacttt gacatttgac tcagctatga ttggttttcc 1615981 aacaattttt cgttttttcc tcaggcaaag taagagatcg aatcatcaaa gccattccat 1616041 ctttactgtc taattaacgc catcttcagt gaatttaaag gtctgtttta aattgcgtcc 1616101 ttcttgcccc ttctgtgtcc aaattataac aacctctaat tcagaggcct tatctgccag 1616161 cataaaatga ttgaacttca gcggtgagcc atcatttaaa ctttcagcta acattttaga 1616221 atcttctttt ggtttgacac aattttcatc gggacatcca aaaagcgaaa accttgtgat 1616281 tgaattaggg tcatttctat acaattgcac atccactgta gctgcttttt cccctatatt 1616341 tttgacttcc aaggaatata cttgatattc tcctttatga ggtctcgtaa attcctttac 1616401 attttttgct tcacttactt ttactgacca ctggtctgtt ttttgtgtaa taggcaacac 1616461 cgtaaaagtc agggcatgcg cttttgattg gcaaaacgta aatccaactg ctgtaaaaac 1616521 aattacagaa aataataccc ttttcacttc atttatccct ccttcctttc actggccgct 1616581 ccttaaagaa ttgattttga gcaatctaca agctctctta accaaaacct tacctgaggt 1616641 tttgtcttta ctgctctgca tttatttctt tcggtatccg agaaggagct ttggggattt 1616701 ttctcaatct gctgttaatc acatcagaag agtatagcgt aataatcata cttcccccat 1616761 acctttttgc ccgaattaag attggttggt tatattggtt ttgaaagcga aagtcaggac 1616821 ctccccagct taccgtcgca tcccgtccgg gcggtacata tggtacactt ctagtatgag 1616881 aatagcgctg aacgatctgc agtcctgcac gatctactgc attaaataga gttgaggaca 1616941 cctgacaaat tcctcctcct acaccttcag acaactcccc ttttacaata atgggtgcac 1617001 ttttatatcc tttgttccga gttctcattc ccacaacttg gttaaacgaa aacgtctcat 1617061 tagggaaaac aacgtgattg tcgattgctt ttgcagaaag agaaatattg tgtgaacggc 1617121 ttttattgct tgagttaaaa tacgtcacgt actgaccaag ctgctgcgta ctgatgtgag 1617181 ctagcagctc gctgtcaact ttcggataaa tgttcatttc cggcacttct atcttggagg 1617241 gaccttgccc ataaaaatac gcataaaact tttccataaa cgcctgttga tacagtttgt 1617301 agccaaccct gcccgggacg atgcttccat gatcgttaag gacagcattt atcggctcac 1617361 ggtacacttt ctgatcaagc tgtttgatga atttactgta tttttcatag tcaaccattg 1617421 gagtgccggg aagaggcatt gtaaagtctt cacggttaac agtggcaatc gtccgtcctt 1617481 gctgtgtgac cgttaaactg tcctgcggct cactcggctg agccaataaa aaaagaccag 1617541 tgatcaaaat ttgtatcata agtcggttta cctcccaatc attagtatga acagccgctt 1617601 atcctttgat gtatttcttc ccatcgtttg tttgaatctt tagacgttga taaaaacctt 1617661 cataaaagag cttagcttta tgttcacacc gatccctgag ctcactgagg cacacggttc 1617721 attcagtcgg caagtttgaa gtagttcagc atctcccagt gatgagggat gcttttttgt 1617781 cttgtcaaaa atgaaaaggg tctcctataa caacaaaaaa tcaatccatt tcaatatttt 1617841 tttattgaga aacgataaat tttttgttac attcaattag acaacaaata aatgaggtgc 1617901 ttgttatgaa tcgaatgtcg acaatttttt taaagatagc tttggttctt attggaattc 1617961 caattcttgc tttatgcatt tttttagtgc ctaaggtagc caactattca gcagaattat 1618021 ttccaaatat cgcttatata aaatatctcg ttttcatcta tttgtatgta acggcgatac 1618081 ctttttactt tgctctttat caagcgttca aacttttaag ctatattgac aaaaacaaag 1618141 ctttctcggg tttgtctgta agagctttga agaatataaa atattgcgca gtcactatca 1618201 gtatctttta cgcagcaggc atgcctgtct tttatctgat ggccgagata gacgacgccc 1618261 cgggtatcat tgtgatcgga ttggttatta tttttgcttc aatggtgatt gcggtctttg 1618321 ctgctgttct tcaaaaactg ttaaaagaag cgattgatat aaaatcagaa aatgacttaa 1618381 cggtctgagg tgatgacatg gcgattatta tcaacattga tgtgatgctt gctaagagga 1618441 aaatgagcgt aacagagctt tcagagagag ttggcatcac catggctaat ctttcgatat 1618501 taaaaaacgg aaaagcaaag gctattcgat tatcaacttt agaagcgatt tgcaaggctt 1618561 tagaatgtca gcccggggat atattggaat accgaagtga tgaagacaca ggattcgtaa 1618621 agaaaaaata tgaaggatca acagaaaaat aaagtgattg gcggtgagct tatggacata 1618681 aacttatatc catctagctg ctatactaag cgtccctttc atacacgaag aacacaacta 1618741 tggaggaggc atacatcatg agagccataa aacaaatcgt ccattttggc tgggaacaag 1618801 ccctttcatg tttgtttcct gccgttattt ttgcctcttt ggctattacg caaatcatcc 1618861 cactgccctt cttgccgcgg tatgactggc tgctcattat ctgcgttctc atgcaattgt 1618921 ggatggtgcg ttccggtctt gagacacggg atgaattaaa agtgatcaca ttattccacc 1618981 ttattgggct tgctctggaa ctttttaaag tccatatggg ctcctggtct tatccagaag 1619041 aaggatactc caaaatattt ggagtacctt tgtatagcgg ctttatgtac gcaagtgtag 1619101 ccagttattt gtgccaggca tggagaaggc ttaaggttga actggttaag tggccgtctt 1619161 tttttgcagt tgttccgctt gccgcagcga tttatttgaa ttttttcacc caccattttt 1619221 ctatagacat tcgatggtgg ttatcagggc ttgtcatcat tgtcttttgg caaacatggg 1619281 ttacatacga ggtgaatgga gctcgttacc gtatgccgct cgcactttct tttatactca 1619341 tcggattttt tatatggata gcggaaaata tcgctacgtt ttttggagct tggaaatatc 1619401 caaaccaaat cgatacatgg agtctcgtac accttggaaa ggtaagttca tggctcttgc 1619461 tagtgattgt tagctttctt atagtagcat cattaaaaca agttaaggag cagagtccca 1619521 caaaggcaga gatggatgaa tctttttctt agcatacgca tacaagctcc caaatagagt 1619581 gaaaagcaac gttcaaatgg ttgctttttt cttttatgta actctgccgg tgagtattca 1619641 tcttcttcaa atttcatcgc aacacgataa ctgattcaga ttacaactgc tttcaacact 1619701 ttgacaaact catgcgccgc cggcgttatc tcttcaaatg aatgtgcgat gacgccaata 1619761 tcgcgtgtga ccctaggaaa gatgtccttt ttaatcaatt gatgcgggac ggatgaaagt 1619821 gtaaagtttg aaatgatgcc gatacccaag ttatttttga ccatattaat caaggtttcg 1619881 gcattttgca cagttaagtt ttcctttaat tcgatgttgt attgcgaaaa tgcgtttgac 1619941 atcgcgattt catgaccgcc tttacaaaaa atgaggtcat cttgatatgt ttcaaggtcg 1620001 acatgctttt caagttttaa ttcgtcacgc tgcggcggga tgacggccac catatagtcg 1620061 ttacacaata gctgattttc aaacggttca aatggagatg ctgcgatccc gatatcaacc 1620121 gtccgatctt caacccatcc ttttatttgg tcagaggttc cttcgatcaa ttctatgcgg 1620181 atcagcgggt agtttgatct gaatgccgca atcgcctgtg gcatgatatt tgttgaaact 1620241 gcaggaaatg aaccaatttt caccttcccg tttaacagct tgttttcccg gttggctact 1620301 tgatatattt tgctttcaat tcccttcatt tgcctcgcca gcagcaatat ttcttttccg 1620361 atgtcagtca gcattaaacc atgatgttta tccctgatca ataatttgag ctgcagtgag 1620421 ctctccaggt tttttatcgc tttacttacc gccggctgag agatgaacaa ttcttttgcc 1620481 gcttctgtaa tatttaattt ctccccaact tttacaaata tgtgaagatg gttcatgttc 1620541 ataaccattt ggttataccc ccaataataa aaatgtattt cagttataca taaatgtaac 1620601 atatgataga aaccagcacg atattttaac aagaaaggcg gcttcattat ggtaaaagtt 1620661 atgctgggaa tcatatctgt cacacttatt tggggttata cttgggttgc gatgaaagta 1620721 ggaattcatg acatcccccc gcttttattt tcgggtttgc gcctgttcat cggagcagtt 1620781 cctttatttc tcattctctt catccaaaga aaaaagcttt caattcaaaa agaacatctc 1620841 aaaagctata tcatcatgag cctgttgatg gggctgggct atatggggat tttgacgtat 1620901 ggaatgcagt ttgtcgattc agggaaaacc tctgttttgg tatatacaat gcctatattt 1620961 gttacggtga tcagccattt ttcattaaac gagaaaatga atgtgtataa aacgatggga 1621021 ctggtctgcg gcctcttcgg actgttattt atatttggaa aggaaatgct caatatcgat 1621081 caaagcgctt tatttgggga gctgtgcgta cttgtggcag cgcttagctg gggaatcgcg 1621141 aatgtgttca gcaagctaca attcaagcat atcgatatta ttcacatgaa tgcctggcac 1621201 cttatgatgg gagccgtcat gttattggtg ttttccttta tatttgaggc ggtcccttca 1621261 gccgagtgga catatcaggc ggtgtggtca ttgctgttta atggcttgct ttccaccggc 1621321 tttacctttg tcgtatggtt ttgggtgctc aatcaaatcc aagcgtcaaa agcatccatg 1621381 gcattaatgt ttgttcccgt attggcccta ttctttggat ggctgcaatt gcacgaacag 1621441 atcaccatca atattatcct cggcgcactg ctgatatgct gcgggatttt tatgaataca 1621501 tttacatttt cacgacggaa agtgtgaatg atatacattt cccctgtcat ttgggcttca 1621561 tgtgacagga gaagactatt acgagaaagt cttctagaat cctgacgaca gcctattaaa 1621621 caatgaaaaa agctaatgtc tgcatgtaga cattagcttg gctggcgttt aggctggtga 1621681 gaatccagat acttttttat taccattctg gctgatcaaa ctgaaaaccg tatagacctt 1621741 ttactttaac atctccgcaa tctggatctt ttgtcaaaat caaataatga gtcttataag 1621801 gcatcgtctc aactcgatca gttgcactaa aatcaaaatg atcccccgag aagttttttt 1621861 cactaacggt tatttcatat cctgacaaag tcattcgcat gattcttgcg ttaattgtac 1621921 atccttcagt atcgaaaatg gtgaatctgt acccaaagtg agatgtccaa tggtttgaat 1621981 ttaggtcatc agacttcata aaccattttt cattctctgt cattgtaaaa ctcactttct 1622041 cctcatcttt cacgataacg gccgaagctt cccctacatg gatagtcaaa gccaaaagaa 1622101 atgtaaaagc taacatcaac atctttttca aaagagttcc tcccgatatc ttttacttca 1622161 atatattgga agggtctttt ctgatcaaga cagtcttctc caaatgaatc tttagcacca 1622221 tgaaatgagc cttaataaga acagttttaa cccaaatcaa cctctattcg aaataaggct 1622281 taccaatcta tattcttttt aaaagtttct gcatttcttt atttagctcc tagacacata 1622341 taaaaaatgc tcctataagt tcaggagcac tacaaaaaac tgctaaagtg ttttctatcg 1622401 atttattgta ttcattagct caaagaaata ttcaggcttt tgagtcttat ttagcttata 1622461 ccatgaacgc aatgtatctg gtgcaaatac atctaatttt ttcaatactt ctaccgcaaa 1622521 ttccagagga gcaattcctg atgcagtaac caaattttca tcagatactg caggcccctt 1622581 ttcatagaat gtttctcctt tgtaattagg gcagaccata ttcatatagt cgaggtcatt 1622641 gcttgtgtgc tttctcgaat ttaagtatcc ttcattcgcg aggcccaagg ttgccccaca 1622701 aattgcagca atagtcgtgc cgagctttaa agcgtcgcca acttttttca agatcggctg 1622761 atgaatatct tctccccaag tgtttcctcc gggtaaaatg ataagatctt gactcccaag 1622821 agtacattcg tcaagagaaa tatctggttt tatgcttaat cctcccaacg tagttatcat 1622881 ttctttatta acccctactg taactacttt taaagatgct gcatcttgtt taaagtatct 1622941 ccctgagttt agttccgcaa ttaaatatcc atattcccag tctgacattg tgtgaaatac 1623001 gtagagataa acttttctcg tttgcatcca ataacactcc aatcacaatt gataaagctt 1623061 tctaatagat gactttgctg acagtcattg tcagcttttt tgttgattct attcttatgc 1623121 ccttgttctc ccaacttata aaaatataag atcaattgat tctatgttta ctagcgcaaa 1623181 ggggtttgtt acactaactg tcatgggaaa catttcaaag gtaatacaaa atcatttgaa 1623241 tgaggaggcc tgatgaagtt gaaaactaaa gcgtcaataa aattcggaat atgtgttggg 1623301 cttttatgtt taagcattac tggtttcaca ccttttttca actcaacaca tgccgaagca 1623361 aaatccatag aagacacaaa catggcaagc tgtataacga ataaaaaatt tgttcaactt 1623421 gagaaaaaat ttgatgccag gcttggtgtt tatgcaattg atataggttc aaacaagaca 1623481 atcgcctatc ggccgaatga acgatttgct tacgcatcaa cctataaagt tctagccgca 1623541 gctgctgtcc tgaagaaaaa ctcaattgaa aaacttaatg aagtcatcca ctacagcaag 1623601 gacgatcttg ttacatattc tccaatcaca gagaaacacc tagatacagg catgagccta 1623661 aaagaaatct cggaagcggc tatccgttac agcgataata ccgctgggaa catcttgttg 1623721 caacagcttg gcggccctaa aggttttgaa aagtcactga aacagattgg ggatcatgta 1623781 acgaaagcta aacgattcga gacggatcta aactctgcga ttcctggtga tattcgtgac 1623841 accagcaccg caaaagcact ggcaaccgat cttaaagcct tcactttaga taacactctc 1623901 acgactgaca aacgcatgat cttaaccgat tggatgcgag gcaatgctac tggtgacgaa 1623961 ctgattcggg caggcgctcc aataggatgg gaagtcggcg ataaatccgg agccggaagt 1624021 tacgggacac gaaacgacat tgctatcgtt tggccgccaa acagagctcc tattgttgtg 1624081 gcaattctgt caaaccgctt tacgaaagat gctaattatg ataatgctct tatcgctgag 1624141 gctgcaaaag tcgtccttaa cgatctcaaa taatatgttt agccttttgc cacaaaggaa 1624201 aagacattac ttttttaact tctaccgttc attttttgat gaacggttct ttcataagac 1624261 ctctagaatc atatatttaa acaccacaaa attaaacatt attataatta acagcaagtt 1624321 ttcattttat ggaacaagta aagtttgaat ctgacaagaa ttaagactaa gcaccctaaa 1624381 atccgttttc ttttcttcca agaatatact ccttagtgca agccattata aagatacaag 1624441 tgaacataca atgcagacaa ctctcttaag tctcttattc tgtgaccaat ttgtaatact 1624501 catgaatatc cggactcact tccaatattt cgtctcgttc gaagacacta acatatcaaa 1624561 ccacttgaat taacataact gaacttgata ttggtcactg gcagtttcaa tgcaatagaa 1624621 caacatttgt tgtctcagag gttatctata tgagaattca acaatttttt tataataatt 1624681 catatttttg tatcgttgca cttggtggat ttgactcttt tcgtgtatgg aaccacactt 1624741 ttattttttc acctcttttg agatcatctg tgttatcaat ctcacttaat cctacaatta 1624801 ctatgttatt tttaaacttg ttcataagtt gtccttcaga aagattgtaa tcttcttttc 1624861 ctggagcttt tgtatcggta atgagaattg ccctttcatt gtctttaagc acgacatagc 1624921 ctactaggct ctgcatcttt gtttcgtctc cgttttgttc atttttattg cagcctgcaa 1624981 ggaaaataat gagcataatg agcactatca agcttactcc gattttaggc atctttcttc 1625041 ctcctcttta aactcatctt taaaataaac aacaggatat cacccaaccc atctacttct 1625101 ttttgcaatt cataacagca gcatactcat tctccaattc ctcaaccttc tttttattct 1625161 ttctcaaata tttgcatgtg gtagccctcg atattatccg cttactcatt tttgcgcttt 1625221 caaatatatt attgaaggcc gcttctttct ggattccagc ataaatatac ttatccttac 1625281 tgtcgtttac tatcgcaact tccattaaaa tcgagatttt tacttttttt atgatccatt 1625341 attcacttcc aaaataactt ccaattacaa cataatatat gtataaattg taaatggagt 1625401 tgatgtaatt gaagattagg aaaatcttat tgagttctgc tttatccttt ggcatgctaa 1625461 tatccgcggt tcccgcattg gctgctggca cttcgtctga ggttgcagta aaaaatgaag 1625521 aatatgatta tgacactata taccgcatta gtcctctgcc aatggacttc cagccaacaa 1625581 tagaatacaa cggttatact tatacgctta cacgtcatta ttttgattac tcaatcgggt 1625641 tttacacggc tatttataca aaagttgttt aaacttataa aggagctttt tagctccttt 1625701 ttctcttgtt ttaagcaagg tatttctttc tatgtggtcc cctatcaaat acaacatcaa 1625761 cattctccag ttctctttga cacgaacaaa atctaaagtt tggttttaaa tgctggtaat 1625821 aaaaaattca ctttaaagaa gtgccgcccg caaaatacgg cttttgtaca ctacgccaat 1625881 tttatattga aaagccagac ctcctcaaag aggttccagc ttttcttaat gtgctatcga 1625941 tcttcgttag ttcaacggga actttatcat tcggtacaaa tgcagcctcc caacttctag 1626001 ttagggctga tggcggaata tctgacggtt ctctacacac atcagacatt agaagatttc 1626061 aatgtagcct tctgtaccat gaacgcgaat tcgttgccca tcttttatca gcttggcagc 1626121 attttcaacg ccaacaactg caggtaagcc atattcacgg gctataacag ctccatgggt 1626181 catcagcccc ccaacttcgg tgactaggcc ttttatggat acaaacaatg gtgtccagct 1626241 tggatcggta aaggaggtaa ctaatatatc tccatcttct aaatccgcat cttccatgtt 1626301 taaaatgaca cgcgctcgcc cctctataac tccggaggaa acaggtagac ctacaatcgc 1626361 tccggctggg agattttctc gtttatactc acctgtaacg atttcaccat cagacgtgat 1626421 aacacgtggt ggagatagtt tttcatataa tgtgtactcg tcttttcgtg tactgatgat 1626481 ttgataatcc agtttatgtg tgcgcacgac ttcgtgaagt tcttcaaaag tgagatagta 1626541 tatatcttct ttttcatgaa taacgcccgc ttctatgagt tgttcggctt ctttcagtaa 1626601 agcctgctta taaacgaagt atcgattaac catgccgtat tttggatatt ccctaaaccc 1626661 gctgaaattc cggatgatat ctatcgctcg ttttgtttct ttggcttttt gttcaccatc 1626721 cggtaattgc ttcaatcgat ctaataactc ttgttctttc ttcaaagctt cctgtcgccc 1626781 ttgctcaaat ttccgatggc cgacattagg ctcaaaattt ttaatattat taagaatcat 1626841 tgggacaagt gtagttggtt tttcgctcca tcgagttctt gtgatatcaa tctctccggt 1626901 acatcgcatt ccgtatttgc tgagataatc atagatcgcg tctcgggttt tgcttccgcc 1626961 atcaaactta gccagttcat ccaaaaagtt atcatctttt acatgttgta agtaatcaat 1627021 tacctctgga taaggacgaa tcacatctgc gacgtctaat agcgcaagac ccatttctga 1627081 agtaatatta tggggtacag attgagaaag cgtatctgct gcgttttttt cacctaacca 1627141 ctcgttcatt ttttcgttaa tccataatga agcattcata gcagttcgaa ttagaaccga 1627201 actttttggg ttaaataaaa tcttctttaa ttcctgaata tcttccagaa taaaacgaaa 1627261 taaatctgat cctgatttcg tttggatgtt ttgttttaac tcttctatcg atgtttgact 1627321 gctctcaatc aaatcagaca cgattgtcgg atcgttttca acttgagccg gcatatctgc 1627381 attgcctctg ctgggatttg gtgctgtttt atcatttggt atcgacttta tgaaatctcg 1627441 tcgctttatt atggtcataa gtgcgtcttt taagagctga tcgtgctgcc ccatgccttt 1627501 taagaaaact tctctgctgt caggggatgc cagatgatgt gtgacatcaa caaatagcct 1627561 tccaccggct ttacgcatgg gtgcaacagt cgtcaacaga aaaaaagaca atcccagtgg 1627621 ttttatggga tccgtcatca tttgttgatg accaacagaa atatagacgt gattttcttg 1627681 gtcactcgct tcagggatgg ggaataaagt agtgattgga cgactctgta caatataaaa 1627741 agtatcgcgg gccaaacacc attcgatatc ttgcggctgg ccgaaatgag cttcgatctg 1627801 tcttccaatg cgtgccagct gtaaaatttg ttcatcagtc agtgtttgag ccttttgctg 1627861 atcagaatcg atctgctgtg tttctgttcc gccttctttt cgtccgtaga tagccatttt 1627921 tttagttgct attctcttat cgatgatttg cccatcctgt actttaaaac aatcggcaga 1627981 taccaagcca gaaaccagtg cttcaccaag tccaaaaccg gcatcgatgg ataacacctt 1628041 tcggttggag gtaatcggat cagcggtaaa taaaatcccc gaagcctgag ggaaaaccat 1628101 cctttgaacg ataacggata aatagacttg gctgtggtca aatccatttt gcatacggta 1628161 aataaccgcg cgatccgtaa atagggacgc ccagcattta ctgatatgct gcaagattgc 1628221 atcgacgccg gtaatattta aataggtgtc ttgttgaccg gcaaaagaag catgtggtaa 1628281 atcctcagca gtcgcactag aacgcacggc ataggcatgt tcctcgccaa actgggagag 1628341 atattgagcc actgctttca caacatcgga aggaatgtct acttccataa tgatttgccg 1628401 aatcttccgg ctgatgttac caatctgatc tcggtcctca acttttagca tggtcaattg 1628461 atccaacaac acttgtaacg tttcgttttg ttcgatggct ttttgatatc ctactgttgt 1628521 gacacaaaat ccttctggta cttgtatacc ttgaattttt gataattccc ctaaatgtaa 1628581 cccttttcct ccaacgagcg aaagctgtgt tttttcaatt tcatgtaaac cgagaaccaa 1628641 agaactcatt ctacatctcc ccttcaaaaa aaaatattga caagagcttc ctagcaggat 1628701 ataataaaat tataagatgg atatctataa ctttttaact agaaagcgca cgtagtgtga 1628761 ttatatcacc gtgtctgttt ttgtgcaata taaaaagaac ctgggaaatt tcaccaggtt 1628821 cttttcttaa tttccatagc tagtcgcatt aaaaaacttg gtttgagctg attcaatcct 1628881 ctaaggaaat cctaaagttg ggttcttttt gaacttactt gctttgttcg tagagtcccc 1628941 attcataaat tggacttttt gttcttaaca gtcccacctt taactagtat aaagttatga 1629001 ggatctggtt aactactaga tatttttatt ttgaataagg cttatgtttg ataaagaagg 1629061 gttatgtaaa ggtgtctgtt gtgagcaagc gctgactaca aaaaattgat agcattctca 1629121 tttaaatacc attctattaa cctataggga aagttttaaa accagatgga gaatacccta 1629181 cctccagcaa ttccaaggcc gttcacctag tagaaaacaa cctttaacca ttactaacga 1629241 ttttaataat cattgattat aaaacttctc aaggaacgat cagcagcccg ttagctaccc 1629301 ctgattaagg atgatctgtt accacactgt tacgttagaa cttccactac tttgatatcc 1629361 ttctgtcgcc atgacttggt aagcccaatt actgcccaga ttcattccat ggctcttcca 1629421 tgcgttcaca tgattgctga aagtgattgt agcgttgctt ccggttggtc tcttcgactg 1629481 gcgaacactc cagtactgcg taaaagtagt gcgatcgcca tcaatggaag gtgcgttata 1629541 acgtgtagtt gtatatatgt catatgtacc cccatcactt tttacagtac ctttatacgt 1629601 tccagtaggt ctataagtac cccatgaatc cactacataa tattctatga gaggtgatct 1629661 cgtccaacca tataaagtta aatatccatt gccattcggc gcccaaactc cggcattata 1629721 gtttatcgtc ctaaatggcg aacctgtagt ccaaccttta ccaacaacaa aatttccggt 1629781 attagaccaa ttaacactgt aattcccgcc agacccattg acagcgttta ctataccgcc 1629841 cccatcagtc caattttgcc agtagtctgt gctagctgca gaggcggttg ccgaaaacaa 1629901 gctaatactc attaaagctg ccgataatcc aactaagaaa ttctttttaa acttaaacat 1629961 atgttacctc ctataatatt ttttccgact ttgaggtagc actcgtatac atttaaaaca 1630021 ttcttaatta ctaacgccaa agcttttgat cgtccccttc agtataatac cacgaattca 1630081 tgagcaaata ttaaaagtat ttgtaattca attacaaata cctagaaaca cattataagt 1630141 ggtcttcttc caccatatcc tgatccgagc tcgatgtaca tgcctttacg gcacacacga 1630201 atgtggcgtg tggtgcatcg cctcaatacg caaagacgtt tgccttaggc aaacgtcttt 1630261 ttttgcgtta tccgattttt gtgccgtttg ggacaggctg atccggctgc aaaaggacga 1630321 cgtcgccctg gccgggtatg ccgccgagga ccaagacttc cgatttaaat ccggcgatcc 1630381 ggcggggcgg aaagttcacg actgctatga cttgcttgtt gatgagacct tccggcttgt 1630441 aacgcttcgt gatttgtgcg ctcgattgtt ttatgccgat ttcagtccca aaatctatca 1630501 caagcttgat tgccggtact cttgcttcag gaaattcttc cgcttttaca attgttcccg 1630561 ttctgatatc caatttctca aagtcatcaa taactgccat atcaataact cctttttctc 1630621 ctattgtaaa ggagatatac aatattcttt taactaaaga gccatcattt tttatccgaa 1630681 tataaggtgt ttcgatacag gcggggcggc attcctgtgc ttttcgtgaa ccatcttgta 1630741 aaagaagaaa ggttttgaaa gcccagcgcc tcgctcacga cggtaagagt ttcatttctc 1630801 tccatcagca ttctttttgc ttcctcaagg cgaaggtcgg caatatagtt ctgcggggac 1630861 ttccctgtct gttttttgaa ccagcttgaa tagtaagctg ggtgataatg ctcgatttct 1630921 gccagcttct taatcgtcag ccgctcaaat aaatggctgt gaatgtatgc aattgaggca 1630981 tagctatggg attgaagctt ttcttttatg tattgtacta gcatatgaag cgagttggct 1631041 gttccggcct ttgcttcctc tgtcagcaag tacctgatcg aagaccagaa aggatcgagg 1631101 gcagcttcaa ttcctgatcc tgcacgatac tcatcaattt tcattgcatg aagcggaaca 1631161 tccagtacaa gacattcatt tcttccgata gaacggaagc gatgctcgca ctgcggcgga 1631221 atatataaaa aatgatccgg atttaatttc acctggcgcc cctcagtctc aagatcaata 1631281 ctcccttcaa gcggaaaaag aaattggctg tacgcgtgct tatgtgaatg atatagccgt 1631341 gtgtatgtcc gtttttcgca aattatctct tgaagcgagt ccattagcaa accccttcct 1631401 ttggtcatct tttaatccgg taatggtgtt ccgatatagg cgaaaagccg atttttccat 1631461 ataaagaaac tgccgccaga ttttctttca tcacttgtaa aaacatgcgt tccgctccgt 1631521 tgttttttgc ccattcagtc aacaccctga tcacttgggt tcctgcccct tttcctctgt 1631581 gctcctcagc tacaacgata ttactaagtc cgccataacc atcaatgaca gaaaccgtgc 1631641 caagcgctgt caggctttct ttgtcataca tcttgaaaaa agttttacac ggcggcatgc 1631701 gttcgaatat gtgtttgtaa cctttgtgac gctcgggtga aaacccttct aattgaataa 1631761 attcatctat ccaaacagat gatggctctt gttcccactt gtatgtaaat cggctgttgt 1631821 catttgttcg gctcataatt gaccggcaca acgctgtcat ctggaagcac tcgtctacct 1631881 tttcataacg gctgtctgcc aatgcgtcat caagcccttt cggtgatgcg ttgctaatat 1631941 gaaaacaaac aggtaagcct aaactttgat aaaaaagttc ggcctctagc tgaaaatccc 1632001 cttcaggcat atccgcagac gtccatacgc tatttgccct tttggttacg ccaaaattcg 1632061 ctctgagaag ccatttccct atgctttttt gaaaataagc cggccatgaa gctgccgcta 1632121 atcgttcaat cttgcgaatg tcatccattg cataatgcct ctcccctatg tatactccct 1632181 tgatattata caatattcag aaatataaga catccattta tttgtttaca taatattttt 1632241 attgtttatt aataatcctg acaaaaatgt ccgaattgaa aatgacaggc tttctaaaat 1632301 gtcctcctca cgttcaaatg cttcttttgc gattaaaaca gtaaagccat gcagcagact 1632361 tctgagcccc cttgtcgcat gaatggcagt cttttcactt gcatagccgt tttcaatgag 1632421 cagcttcgtc acaagacaga caatttggtc agagacgatt tccgtccgtt tgtcgtgaac 1632481 cttaagaaga gccgcttcat aatatccggg attttcaatt gcaaaatcaa catatgcatg 1632541 agctaaagaa agcatcgcgg aatctccctt tcgttcggtt acggagtccg ccatttgatc 1632601 aaaaagcttt gtcagtcctc tgacagcaag ttctgctctg atcgcttgca gcccgttgat 1632661 atggttatac aatgacgggg ggcgaacatt cattttttta gaaagtgcag caagtgagac 1632721 accatttacc ccttcctgat cggcaatctc tgctgcagcg tctacaatca ttttttgggt 1632781 caaacctatt ctcggtgaca tgctcatcat cctttctttg ctttttggat cgcctgtctc 1632841 atccgctctg aaggtgatcg caggaatttt ccatgtccga cagcgagaca ggaaggcgcc 1632901 ttatcggcga gcaattgtgc acttttgatg gcctcctcct tattccatgt ggcgaaagcg 1632961 ggaaaaggaa acgcccattt tatctgacct gatacagcga ttcctccgcg caactgaaac 1633021 gcatctcctg ctattaaagt gccgtttctt gtatcaagaa atgacatgct gcccggtgta 1633081 tggcccggtg ttggaatggc aagcagagaa ccaattgttt caccgcccgt cagcagttgg 1633141 tgaggctttg tttgtatgtg tttcggaata cctcctttta taggcgtctg cggctcatct 1633201 tgccgcaaag atgtgtcacc ttggagcaag aatgaatccc gttccgagat catgaccttt 1633261 gcatgcggaa atgtttgtgc caatgtatcc agtgatccga catggtcccc atgtgcatga 1633321 gtcagtaaaa tatgctgaag cggttttcca agctgattca cagcttgaat aatcccttta 1633381 tagctgcctg gcagtgcggc atcaataagg gtgacttcgt tttcttcctc tactaaatag 1633441 caattaaccg gaaacaatgc tggaaaaaaa gtcagctgcc aaaccgtttg gtactgagta 1633501 attctcatct ttttattcct cctaacaaaa actaatggtg ttagttttat tattaactaa 1633561 caccattagt ttttcaagag tttattattt ttttatcgct acataaatgt taacttgtgc 1633621 tcgctgtggc actgcggcat tttgatcata catctcaaag tcacctgtaa acgtgcgcag 1633681 atgccgctta tcccaagtcc aaatttcctt ccacgtttca agcacaatct cttcaatagg 1633741 accgattctg gaagtgaaaa cggcgtaagc ggaagccggc aaatcaatat tttcatatgg 1633801 tcccggaaga atgtcgtcgt attcctgaaa cgttccgact gaaaacgtat aaaacccatt 1633861 cgtctcttgt tcataattcg aatataaggc aataatgctc ttgtcttttt cagcctgtga 1633921 taaaagagcg ctcatatcct gcttccataa ttgatcccac agtgccggaa tcctcctttc 1633981 ttccgtcatt tccagtgcgt tgcttgtccg ttgtgatagt ccggcaaatc gtttcaggtc 1634041 taagtgtgtt atatgtgaaa agcccatacg atctcctcct ttttttaaga ttatagacaa 1634101 agaaacctga cagcagtgtg tcaggtttca tatatttttt gcatgtgatg aatggtttct 1634161 tttactttat cccttatatg aagaggctgc agaacctcaa tatcctttcc gaactggagc 1634221 aaaaaaccga tcagccattg atcttctgga agtgaaatca ccgcctggca gatttcatct 1634281 tcctcacaac agtgaaggac atcatatccg aaccattcac ctatacgctg acgtgctgac 1634341 ggctgaacaa gaataaccaa ttcagttaaa cggtcctttt ggtaccaact cttatcccat 1634401 ggcaaagtgt ccagctgaat gtcttttctg ataaatgtct gatgtaagat ggccagatct 1634461 ttcatccggt tcagtttaaa aaagcgaaaa tcatttctta ccaggcagta ggcatataaa 1634521 taccagtgcc ccgccttgca aaccaatgta taaggttcag tttcccgaag tagtgtttcc 1634581 ccgcttgcgc ttgtatatgt aaaagatatc gttaacaacc gatcgatggc agcgctgatt 1634641 ttctcgcgca gcgtcttttg atcctcagta tggccccaag ccgtcatgtc aataaaccat 1634701 ttttctgttt ggtgcttaaa tgcttgagta gattgctcag gtataaggtg tttgattttt 1634761 tgataggctg tgctgtgaga aacgggttca tacatagatg aaacgctttg caaagcggaa 1634821 gcaattgcaa acaattcctc ctccttcagc cactctcttt caagccgata cgtttccatg 1634881 atgccaattc cgcccccgga accctgtgag gtcacaatcg gaataccagc cctattgatc 1634941 gtctcaatat cacggtaaat tgttctgaca gatacttcaa acagctcagc aagctctgca 1635001 gcctgcactt gttttttgct gatcaataac acaaccatcg ctaacaaacg ttccagtttc 1635061 attctgcgca ccttttcttc ttgtattttc caacaaaaca atcataacat tttgataaag 1635121 cttgggcata tctattatgc ggcggaatac acctcgcata tgctatgaaa acaggggttt 1635181 ccccttcttt tttgtgttca gtatttattt cagctactat ttccgaccgg ataagcatac 1635241 acttctcaac ggaggggatt tcacatcatg catcttacac ttcagagcgt ttatcctgcc 1635301 ataatcatca tcttttttct gtataaaaaa attaaaaggt ccatcggata ccagccgctg 1635361 aagccccgct ggctgttcac ccgtatcatt cttttctcgc tgtttgcttt tggactttca 1635421 atcttcagcg ccattcaccc ttttttatat ggatatctca ttttgggcat tcttggcgga 1635481 tggctccttg tctttttcgc taagaaaaac atctcttttg aaaaacgcag aggaaagatc 1635541 tattttcgga ctcatatttg ggtagaggtg attctcttaa ctttatttct atcaagattt 1635601 ctgtatcgag tgacggagct ttatcttacc tcacctgatc taaaccgcct tggatcatac 1635661 agtcagtcaa tcggaacgga ccctctgaca attggcgtct gttttctgat agccgtttat 1635721 tatatcggtt tttcttcttt tatcatcaag ctcagcagaa acgaacttga acagcacgaa 1635781 tacaataaag aaaaagacat ccttgcccgc taacagcgag ttaagcaagg atgtcttttt 1635841 caatcatgct gtgtatgatg gatcatttgc tgaagaacat ctaaaacatg ttcatcctcc 1635901 ggagagtaat aaatcgatgt tccttctctg cgcgatttga caagccggag attttttaaa 1635961 aatctaagct ggtgggacac agtggattgc agtaaattca gcttttctgc aattccgttt 1636021 actgcatgct caccttggga caataaatgg agaattctga ttcgggtagg atctgaaagc 1636081 gctttgaatg tttgcgcgac tagaaacagc gtctcctcgt ccagatcagc agccgattgt 1636141 tccgtttctc taaattcagt catatgtatc acctttcttt attcatagtt ttatcttata 1636201 acaaatgcgc ttgagtgcaa accagcctgc ttgtattcca tttcaatctc atagtttaaa 1636261 tttatgtttc aaatcaggtt tttacttggt ctgatatacc ctcttatgtc ataataaaaa 1636321 aggtcatact gctccaaaca ttgagggtga aacacagtga agaaaaagag aaaaggctgt 1636381 ttcgctgctg cgggttttat gatgattttt gtctttgtca tcgcctcttt tttattggtc 1636441 ctgctttttt tcaaccggga tttaatcaaa aaacttccga tcgatacgaa aacgattgtt 1636501 ttggaacgtt taaccgatta caaacccttg gtggaagaag agcttgaaag ccaaggactc 1636561 tctaattata catcactcat attaggcatg atgtatcagg agtcaaaagg aaaaggcaat 1636621 gatcccatgc agtcctctga atctctgggg ttaaaacgca atgagataac agaccctcaa 1636681 ctcagtgtta aacaaggcat caagcaattt accctcatgt acaagaccgg taaggaaaaa 1636741 ggcgtggatt tggataccat tattcaaagc tacaacatgg gggcaggtta cattgatttt 1636801 gtagctgaac atggaggaac gcatactgag gaattggcaa aacaatactc cgagcagcaa 1636861 gtcaaaaaaa atcctgatct gtatacttgc gggggaaatg cgaaaaattt ccgctatccg 1636921 tattgctacg gtgattatac gtatgcagaa aaagtaaaag aaaaaacaaa aactgttgaa 1636981 gaatctttgc aggttgcaac acttgaaacc atggaatcca aggctcatga ataagagtct 1637041 atcaatttac tgacaaaagc ccaaaaatga atttgggctt ttgccatgtt tacacgtaaa 1637101 aaaagccata ctgagtatgg cttttaataa tacggtgaaa tcatcaaata tacaataacg 1637161 cctgtaaggc ttacatacag ccatagaggc attgtccatc tcgcaatttt tttatggcgc 1637221 tccacctgca tgctgaagcc tctgatcagc gtaaacagcg caagcggcac aataattgca 1637281 gaaaggcaga tatgtgtaat taaaataaag aaataaatcg ggcgcataat accttctccg 1637341 ccatagagcg tgttttccgc aatcgagtgg tacgtcacat agcaaatcaa aaatagtaat 1637401 gttgttgtga acgcagccaa aataaagcgt ttgtgagctt tgatattttt ctgtttaatc 1637461 ataatcagcg cggccaataa gaagataaac gtaaagctat tgaatatcgc attcagcatt 1637521 ggcaaaatgt gaatattcgc atggctgaac tgatctaatt taggcataaa aaacagcact 1637581 gcgattaaac cgttaatcag aactgtcagc gtaaggacaa tccccgtgta atttttcggt 1637641 ttattttctg tttggttcat ttggtgacct ctcctaattt gtactggcta tccaaatcgt 1637701 atgcaaattc aaagaagatg tcaacggttt cgattgcttc gtcagaaatt agacacactt 1637761 caaaggccgg aggctattag ccccggcctg ttaggtttac gcctctttta tcaaatgttc 1637821 aatgacctta tgttcatttt cattcagcag gttcttttga attttcgaat gaatgggttt 1637881 attcatatgc tgatccaaga tatcggccgt ttctttatcc ccggcaataa ccattcgttc 1637941 ccatcttttc gcggcagctt tttgatcaag gctggcagcc agccgcttat acagtctcga 1638001 ttggttctct gttacatgtt ccctcatccg gttctcttca aatggtggcg ctttgtctac 1638061 agcggaatgg ctattcttcc aagactcatt gatcatatca tactcataac gctccaccgc 1638121 ctcaattttt cctaaaacag tttcaataat tttcacttca tgctgctgag ttaaaataaa 1638181 cgccgtactt gggtatgtct ggcgcaaacc ctttagctga tccaggacag ctgtttcttc 1638241 ccagtaaaat cttgtatcta cagggacttg aagcttaata ggttcccata tgccgctgtc 1638301 ggaaacaaaa aacacgagac tgcggggcat gtcttttccc attgcattca agtattgatt 1638361 cattttagcc ctgattccat ccagacactt ttcctcctct ggatcactag ctgccaaata 1638421 ctcttttaat cggctgaatc ctgactttag ggcaatcttc cattctcccc cctgctgctc 1638481 tggatctctc atgtctgtat tgagatacag agagagaatt ttatccggcg gttccaattg 1638541 gacatactgt aatttgttaa tcaatgaatc aatcgccatt ccgattcctc ctttttcaca 1638601 ggttagtttt ctttttcctc tcttaaaaac gatcaaacct gactttccgc taatttctag 1638661 taataatgga attgttgttt acaatacgcc tctcttctaa tacaattggt aactgtgttt 1638721 ctaagctgtt ttttgaaagg agtttgatct tgtttactgt taaagaaaaa aatcgtcaag 1638781 agcttgagga agaactaaat gatttagaat ttcaaattta tcgcatgcag gagaatatga 1638841 aggatttatc taaagatgcc aaagtgcttg gtattgatca atcgaaacat gatgagtgga 1638901 tgattgtttc ctcgattgat gatggccaaa catgcaaaat tatgctaact gattgtaaaa 1638961 cggcataccg aggaaaaggc tgtttttcac ttgtagcgtc ttacaaggac gatgccattc 1639021 atatagggga tataaaaggc cctccgaatc acgggtttgg ctccatttgc atgaaatatt 1639081 taaaagatat tgcaagagac cataatatac cgaaagtcac cggagacatc gccaaacggg 1639141 attggaatca tgtagaccgg ctgattcact tttatgaaaa acatcacttc aaagtatgta 1639201 tcgatcatga tacccaatcc ggcagcatta agtgggttga tttgtaaaaa agtctggaag 1639261 aaagagccaa gatatgctgt aatggtataa aaccattgat ggagggttct atgtacgcct 1639321 caaaactgaa aaagggagac gaaatccgga tcgtgtctcc cgcgaccagc atgtctatat 1639381 tatcaaatga agcaaaaatc caagcaaaaa cggcgttaga acgcttaggt tatcgggtaa 1639441 ccatcgctga acacgcaaat gaatgtaacg aatttgattc atcctctatc gagtcaagag 1639501 tccatgatct gcacgctgcc ttttttgatc caggcgtcaa agcgatttta acgacactcg 1639561 gagggtttaa ttcaaatcag ctgctgcgtt atcttgatta cgagaaaatc aaacgacatc 1639621 caaaaattct gtgcggttat tccgatataa ccgctctttg caacgctatt tatcaaaaaa 1639681 cgggtcttgt tacgtattca ggtccccact tctcaacatt tgcaatgaaa aaaggactcg 1639741 attatacaga ggagtatttt ctttcttgct gcgcttcaga cgatccgttt gaaattcacc 1639801 cctcaagtga gtggagcgat gatcgctggt ttttggatca agaaaacagg cgtttttatc 1639861 ctaataacgg ccctgttgta atccaagaag gttatgcgga aggtacttta attggcggaa 1639921 acttatgcac gcttaatttg ctgcagggaa cggagtattt tcccgaaaca gaacatacta 1639981 ttttattgat tgaagatgat tatatgtcag acatccatat gtttgaccgc gatctgcaat 1640041 cactcatcca cctccccgct ttttcacatg taaaggcgat tttgatcggc agatttcaga 1640101 aagcatcaaa cgtatcaata gatcttgtaa aagccatgat cgaaacaaaa aaagaattat 1640161 ccggcatccc gatcatcgca aatataaatg ccggacatac ctcgccaatt gccacgttcc 1640221 ctataggagg aacatgcagg attgaagcta tttcgggtac atcacgaata tggattgata 1640281 aacattaatc agcttgtaaa tttttttaca agctttttta gcgcaatcgg ctatgcatgc 1640341 cgcacgagac atgacaaatg tcatatagga ggcatgatgt gtgctactac aaaagacttc 1640401 tctcattagc gtatactgaa ccgagacaca caatgagagg atacttacta tgactgaaca 1640461 aaccattgca cataaacaaa aacagctgac aaagcaagtc gctgcatttg ctcagcctga 1640521 aacaaaaaac agcctgattc agcttttaaa cacgtttatc ccattcttcg gcctatggtt 1640581 tcttgcttat ctcagcctcg atgtctccta tcttcttacg ttagcattaa cggtgattgc 1640641 cgcaggtttt ctgacaagaa tttttatcat cttccatgac tgctgccatc aatctttttt 1640701 caaacaaaaa cgctataacc acattctcgg ttttctgaca ggtgtcctga ctttattccc 1640761 gtatcttcaa tggcagcaca gccattcgat tcatcatgca actagcagca atctggataa 1640821 acgcggaaca ggagacatct ggatgttaac agtaaacgaa tataaagctg catccagacg 1640881 aacaaagctt gcatacagac tttatagaaa cccgtttatc atgtttattc tcggaccgat 1640941 ttatgttttt ctgatcacga accgttttaa caaaaaaggc gcaagacgca aggaacgtgt 1641001 aaacacatac cttacgaatc tggcaattgt cgcgttggct gccgcttgct gtctgatctt 1641061 tggctggcaa tcgtttttac tggtgcaagg cccgatattt ctgatttcag gttcaatcgg 1641121 tgtttggctg ttttatgtgc agcatacctt tgaagattct tattttgaag cggatgaaaa 1641181 ctggagctac gttcaggctg ctgttgaagg cagctcattt tataaactcc cgaaactgct 1641241 tcaatggcta acaggcaata ttggttacca ccacgttcat catttgagtc caaaggtgcc 1641301 taactataag cttgaagttg ctcatgaaca tcacgaacca ttaaaaaacg taccgacaat 1641361 caccttaaaa acaagcctgc aatcacttgc gttccgtcta tgggatgaag ataacaaaca 1641421 gtttgtgtca tttcgggcta taaaacatat acctgtaagc cttccgcctg attcaccaga 1641481 aaaacagaag ctgcggaaga atgcctgatg ataaaggagg tcttctaata tactagaagg 1641541 cttccttttt attgttggag ggtgcattct ggctttcaca atgataaagt tacaagtaag 1641601 atgaaaagct gaaaatgagg taagatcatg attaaaaatc attttacatt tcaaaaacta 1641661 aacgggatta cgccctatat atggacgata tttttcatcc tccccttcta ctttatatgg 1641721 aaatcatcat ctacatttgt tattattgtc ggcatcattt tgacgctttt atttttttcg 1641781 gtatatcgat ttgcttttgt ctcaaaaggc tggaccattt atttgtgggg atttttatta 1641841 attggcattt caaccgcctc cattactctg ttcagttata tttattttgc tttctttatt 1641901 gcttatttta ttggaaacat taaggaacgc gtcccttttc atattttata ttatgtccat 1641961 ttaataagcg cggccgtcgc agccaatttc agtctcgtat taaaaaagga attctttctg 1642021 acacaaattc cttttgtcgt tattaccctc atcagcgcaa ttttattgcc cttcagtata 1642081 aaaagccgca aggagcgcga acgacttgaa gaaaagctcg aggatgcaaa tgaacggatt 1642141 gcagaactgg taaaattaga agaacgtcag cgaattgccc gcgatctcca tgatacgctt 1642201 gggcaaaagc tttctcttat tggtttaaaa agcgacttag caagaaaatt gatatacaaa 1642261 gatcccgaac aagcagctcg tgaactgaaa agtgttcagc aaacagcgcg aacttcttta 1642321 aatgaagtaa gaaaaatcgt ttcctctatg aagggcatcc ggctcaagga tgaattgatc 1642381 aacatcaaac aaattctcga agcagctgac attatgttta tctatgaaga agagaaatgg 1642441 cccgagaata tctcattgct gaatgaaaac attttgagca tgtgcttaaa ggaagctgtc 1642501 acaaatgtcg tcaaacacag ccaggctaaa acttgccgag ttgacattca gcagctctgg 1642561 aaggaagttg tgattacagt gtctgacgat ggaacattca aaggagaaga aaattccttt 1642621 tcaaaaggac atggcttact cgggatgaga gaacggcttg agtttgcaaa cggaagcctt 1642681 cacatcgata ccgaaaacgg gaccaagctt accatggcaa ttcctaataa ttcaaaataa 1642741 acataaagga tggcttatat gattagtata tttattgcag aagatcagca aatgctgctg 1642801 ggcgctttag gatcacttct aaacctcgaa gacgatatgg aagtcgtagg caaaggtaca 1642861 accggccaag atgctgttga ttttgtcaaa aaacgccagc ctgatgtatg tattatggac 1642921 attgaaatgc ccggaaaaac agggcttgaa gctgctgagg agctaaaaga tacaggctgc 1642981 aaaattatca tcttaaccac cttcgccaga cccggttact ttcagagagc tattaaagct 1643041 ggcgttaaag gctatttgtt aaaagacagt ccgagtgaag agctggccaa cgccatccgt 1643101 agcgtcatga acggaaaacg catctatgca cctgaactga tggaggactt atacagcgaa 1643161 gctaaccctc ttacagatag agaaaaagaa gtgctcgaac ttgtggctga cggtaaaaac 1643221 acaaaagaaa tcgctcagga actcagcatc aaaagcggga cggtgcggaa ttatatctca 1643281 atgattctag aaaagcttga agtgaaaaat cgaattgaag ccattacccg gtcaaaagaa 1643341 aaaggctggt ttaaataaaa aaggatcttg gcatctgcca ggatcctttt tgttaacctg 1643401 aaattcccgt ttgagaacct cgtcgcaacc agaattaaat tgatccatat cctcgctcct 1643461 acgcccgctg aacgattgtt tggttaacag cccaataaaa gactggattg aatgatatcc 1643521 ctgttaaaat ggtcggccat tgcacatcag cagaatttct gatattgatt atattgtatt 1643581 ttcagtatga caaagttgtg ccacttcgct cccgaagctg ccatgcccaa ctgcaagagc 1643641 ctaatatcac aataaaaaac cgtctgaaat caatccgatt ccgtaaatgg tatctgctac 1643701 atccaactgc ttattatctg ccaaaaacac cagctcgttt cgctgatcaa agatagtaac 1643761 aaccagctat aaatgtcatg atgccgaatg tctctgtaat gtggaatcaa tcttttaacc 1643821 cgagagcccc tgaatcgcac ataaagaaaa acgggaccac tttcttttat cagcatatga 1643881 tataaacagc tctaagcaga acaaaaaaag acacaagcca aaagcttatg tcttttatca 1643941 caatctatat tattagttta agactttaac acttacagtt ttgacgcccc aattagaagc 1644001 atcactttta cttggtacaa atacgtcgat tttatttcct ttaatagcgc cgccagtgtc 1644061 tgctgctgtt gcttccccgt agccttcaac atagacttta gaacctagcg gaattacatt 1644121 aggatcaacc gcaataactt tcgcgttcgg gttcttattt aagtcaatgc ctgtagctgt 1644181 aacgccggaa atgccgccgt cgttagcagt gtaagcagta gcagtaactg ttagttcttt 1644241 tgaagcttct tgattatttg tatttgattg aacagccttc tcctctgtgt taacagaagt 1644301 ttctgcctca gcctttgttt cttgtttagg ttgctgttgt acagcttctt gtttaggttg 1644361 ctctttttgc acagcctctt gttttggcgc agcttgaggt gcgtttgttt gcgcattctc 1644421 agtagctgtg tttgctgctg ttgcctgacc ttttactgaa agagttgatc cagcatagat 1644481 catgtcagag cttaagttat tccaaacttt caggttgttg actgtcgtgc cgaatttttg 1644541 agcaatctta gaaagcgtat ctcccgcttt aattgtatat tgcccagtcg tggttgtttc 1644601 ttctgaagaa atggtcagtt tttctcctgc aatgatttta tcagaagtta acttgttcca 1644661 ttcttttaag tcctttaggt tcactccatt tttctgagag attccccaga gcgtatcacc 1644721 cttttgcacc gtaatttctt ttgcagaagc gtgagctccg aatgcagttg ttgaaagtgc 1644781 agcaactgcc acaaaggaca taatcgtctt cttcataagt aaatcctccc ttgttagctt 1644841 tttattggcg gctaacaggt gatatcgtaa cacacgtaaa tgtcaaatca ataacaaaaa 1644901 gatatgattt agattacagt tcctttacat gaaggatttc tctctgatgg aaagacttgc 1644961 tgaacccttg atataatagg cttcgcaggt ctttttattt tgaggcgaaa cagagaaaat 1645021 aaaatgtgtt ttttatagaa aaaaagattg tttttctgtt tttttagtct gtcatccttg 1645081 cataagcctg tatttcttgt aaaaaaagcc ggccgtattt tgctcttttt tgttctccga 1645141 ctccttttat agacaaaagt tcatcatcat ttacgggctg ttttcctgac atttctttta 1645201 acgtttggtc agagaaaaca acaaatggcg gaacaccctg ctcagccgca atttctttcc 1645261 gaaccatgcg caatcgttca aatagctcgt cattttcagt aatcgctgcc gcttttaacg 1645321 cttcttttct cgctactgat aattctcctt tcagcacatt ccttccttta ctgctgacaa 1645381 aaagagtcgg aaacgttccg tctgacatcc tgatgaagtc gtcagaaata agaaattcga 1645441 taaaatcact gatttcgcca acggattggt gttttaatat cccgtatgtt gaaaggtcgg 1645501 aaaagccgtt ttcaagaact tttttatttt tggagccggc aagcacctgg gcaaccatcg 1645561 tcttgccaaa ccgttctttc atgcgaatga tacaagataa gaccatttgc gcctcccgcg 1645621 tcacgtcatg ggccgctctt gtatcggtac agtttccgca ctgtccgcac gcatcaggct 1645681 ccttttctcc gaaatacata aggataaaac gctgcagaca atcttccgta tgacagtagt 1645741 cgaccatttg tctcagcttt tttaaatcct gcttttgttt ctcttcatgt tctgattgct 1645801 caattaagaa gcgctgcacc ataatatcct gcggtgaaaa caggagaaca cattcactgg 1645861 caagaccgtc ccgtccagct cgtcctgcct cttgataata gctttccata tctttcggga 1645921 tttgtgcatg cagaacaaat ctgatatttg atttatcaat acccattcca aaagcagagg 1645981 ttgccaccat cacttgaagc tcatcattaa gaaatctttc ctgctgctct tttctcacat 1646041 catcagccaa acctccatga taccggcctg ccctgacctg atttcgtttc aatctctcat 1646101 atatccgatc agcttctttt ctggtcgctg tatagacaat tcctgcttca tgcctgttgt 1646161 tttgcacata ttcgtctata aaccgatctt tattttctcc ttttactact ttaaaggtta 1646221 aattctctcg ggaaaatccg gtatataccg tgttttcttt ttgaatatgc agctgtttgc 1646281 aaatatcatc atgaacctcg ggtgtggctg ttgctgttaa cgccatgatg acaggcttgt 1646341 cgtgtaattc acggaacaag atttcaatat tcctgtagct tggcctgaaa tcatggcccc 1646401 attgagaaat acaatgcgcc tcgtctattg cgaccaaagg aacatctatg ccctgcaaaa 1646461 tccggataaa ctctatggac gttagtcgct ctggtgtaat gtaaaaaagc ttataagccc 1646521 cttctttgag tccgttcagc ctctcatata tttcctgatt ggattgtgtg ctgttaatgt 1646581 aggcggcgtt aatccccgct tcttctaacg catcaacttg atccttcatc aaggaaatca 1646641 acggtgaaat gacgatcgtc gtcccttcaa acattaatgc cggaatctga tagcaaatcg 1646701 atttgccgcc tcccgtcggc ataatgcagg ccgtattttg cctcgcttcc gtcaccaagc 1646761 ggatcgcttc atcttggccg ctccgaaact tctcataacc aaaataatga gccagaaggg 1646821 attgggctct atgtaacata acgtgtaaac ctcgcttttc cttgaatttc tcccatcata 1646881 tcataaaaaa gcggccttca tttctttcac acaaaaatgg aatattcact ataccaaacc 1646941 tttttagata aaataaaaag ccatttccga aaaggaaatg gctttcgcta cgtcttgccg 1647001 tatgcaagta agaaagtttt aaaccaccac tcctcaaagt gggtgtttgc agaaacgttc 1647061 ctgtcgtcct ctgcaatgga ggcatgacat tccggcttcg atataaaact ccctattaca 1647121 gcttaaaggt taaaacttaa ttaacaatac gcacaaagta gcttctttaa tatagtacac 1647181 catcaggcgc ttttaatcaa gaggtcagaa caattgttta gaaaaacttt ttccagtgaa 1647241 taaaactgtt ttttctccaa aatacctgac aattcgacaa acaaaaaata tattacaata 1647301 aaaaaaatag cctttattgc taaaagcgaa tgattatttt cttctatatt aatgtgtata 1647361 tacaaaaaga ctcctatttg taacgatagg agtcttggct ttattagaat tttgcagcaa 1647421 gatcttttgc ttcttgtaaa cctttttcaa cgatttcttg cgcttgatca ggtgctgcgt 1647481 tatgtccttc gatgacaact gtgtgcaagt cttgaacacc ccagaaacca agaactgttt 1647541 tcatgaagtt taatgacatt tcaagtgcag ccattggtcc ttctgagtag acaccgccgc 1647601 gagcgttaag aagcgcaact tttttgccgc ccattaaacc gactggtcct tcttgtgtgt 1647661 atttgaatgt aacgcctgcg cgagacagat aatcaacata agtatgaagc actgctggca 1647721 ctgtgaagtt ccaaagcggg aatgcgaaaa caactttgtc agcttttaca aactggttca 1647781 gatatttgtc agcaattgct gcttgttttt tctcatcttc tgtcatttcc attccttgac 1647841 ctgctttaaa tgttccgtta atcatatctc tgccaaggta aggaaggttt tccttatgaa 1647901 gatctaattc aaccacttca tcattagggt tgttttcttt ataagcagct aagaaagctt 1647961 cgtaaagttt agttgaaacg ccttcttcag ctgtacggtc gcttgatttt acaaataaaa 1648021 ctgtagacat ttgtattcct cccggtaaac tttttatatt tacttacaaa tagtatgtta 1648081 ctttcttttt tacgtaaagt caatcacttt attttgaata tgagattttt tttcaaaaaa 1648141 aagcaagtac atctaatatc ggtgtacttg cttggcattt ttacttcgaa tcttgttcac 1648201 gatccaagat ttcatacgtc tgcgagcttt tttgatcaat tgtttctttg ttggataagt 1648261 cttttacctg ttcatgaaac tctctttcat aagaaggagc atctgtctcc agatcatcct 1648321 ccacatcagc ttgggcctca actgtcattc ttgcataagg aacagcttca agtctttcgt 1648381 aaggaatctc ttggccggtt ttttcacaca cgccataagt tccgtctttc atcttttgta 1648441 atgcacggtt gacctcctct aacagctccc ggtcaatctc tttcactgtt tggtctgtca 1648501 tccggtctgt gacgagcgtc ccgtggtctg ccatatggtt gtcaacccca ttggaaagct 1648561 cccccacttc ttccgtcatt gattctgttt cctttttctc gccagacaat tctttttgca 1648621 tatcgagcaa tttatgatag agatgctgtg tttgttcttt tgtcagtgcc atgtatatcc 1648681 tctcctttct atcctgtttc ccgttttgcc ttctgtcaaa catggaaaca tcgatggaaa 1648741 gatgagctac tgcctttttg aacggatcgt gaccgctggc gtcgatggtg cttcgggttt 1648801 tcgttggcac tttttgtcct tctcttctgg cggtatataa taggttgcgc ctatatttaa 1648861 tctgccgctc agttcatcaa tggtcagctc gccgaattca agatgatagt caactttttc 1648921 gacattcagc gtttcaatat gtatataggt ttcttcagac tcttgtttgc tgctttgttt 1648981 ttgtttctca atcactgaga gtctttcttc acattcacgc agtttgtcaa gttctggttt 1649041 caagcaatgc ctgatcagcg accggaacat ttttttcatg acatcacgac cctttgcata 1649101 ctcctctttc gtctacatat ataatgaggt atatcccata gaaaggagag gttttcatgc 1649161 ttccgactaa catcaatatt tctcatctca agactaactc gataggcacc ggctcatccc 1649221 ttacctttgg ttctgcggag ttaaggaaca ggtgctctgc tatcaaaaga aataacggtt 1649281 ttggggaaca aaatgcagat ggtattgtta tggtcattcc gattgaatca attgatgacc 1649341 gtgatgtgtc agatgcactc agtatgaaaa tcaatcatca ataacaatgg ttttcgcttg 1649401 accttcgtct ttttgaatag tgatgtatag gattccgtct ttaaaaatgg cattcatctt 1649461 tccatgaaga tgatcggaaa gcggaatttt cttttcaaaa cttccgtatt tcccttcttt 1649521 ttggcgaaag tcctgttcat taaaatagga aaagcgctgc cccttcacca ctaaataatc 1649581 tccgtacgat aatatgtgaa cgtcttgttt acggtagcct ggaagataaa ttaaaaactg 1649641 cacttccgca acggtatcta caatatccat gctcggaaat gaagcatctc ctttccctcg 1649701 ctgatcttgc tgcgcaaacg gaaacggaga ttggccattt gtcataaaag gggttttttg 1649761 gtcttcatca aatacctgtt tccaaaagtc accgccgtac atctgctgtg cgaattccat 1649821 ccactgcttc atcttttcga aatccatttg aagccccctg tcttaacata ctttataacc 1649881 gccagcatac aactatagaa aggaggtttg cctgtggttc aaccaactcc gtatatcaat 1649941 attaatattt tcatgctgaa aattaattcc tttgaaaatg cttcagcggt taacgtagga 1650001 caaaatttat tggcagaatg gcaaaattca gataaaaaaa atcaaggcta cggacagaat 1650061 tttggagatg cgagcggatt tatgggcacg agaagccatg tggatgacag agaccaaatt 1650121 gattctccgg cctcttttga aagtgaagcg gttaactcct caatcaaaag gaagtgatga 1650181 gatgttcttt tcaccctccg tcgtaaatgt cggcggattt aaaatcaata cgatggatcg 1650241 aggttcctct ttaacactcg gtccgtatca gcaggtcgat tactttttat cagctaaaat 1650301 aaatcaaggg tttggagaag aaaatggcga ctttactcct cttgtcgtgc cgatttcaaa 1650361 tgtattagat gcagatcttg ttgattcgaa ctcagcgaaa aacagtgtgg tgtaataaga 1650421 acagggcgca catgccctgt tcttgttttt atatataaaa aaagcctaac cattttttga 1650481 acggctggct catcaaatat tcagctgcac aaatgctttg tcagcaccgc ctgaacctcg 1650541 cttaaatcgg tgtctttcgc aaattctaat tcgaaagttt tgcttcttgt catcaataaa 1650601 agcccagtgt ccggatcaaa cattcccgct tcttggatgg caaagctttc aattgtttta 1650661 tatggaagaa atacacgaac cttcttttta gaaaacattt tattgtcaaa gaaaatgatc 1650721 cgcttatttg taaagcaaat ttggtccact cggagcttat aaatcgattc aattctttcc 1650781 ccttcaacga gcaaagcctc aagcttcttt gcgtccgttg atctgctaac agaaaaaata 1650841 cccaatgaag aacccctctt tctgcattta tctatttgtt ttatcattca ctacataaaa 1650901 ataagtcctt tatccctata taagaatacg acatagaaga catttaaacc attacgaaca 1650961 gattacattt ttcaaatttt tgatttgttt tttggctttt aagctgttgt catcaagtaa 1651021 tacgcacata tagagaaaaa agtttcaata ttcagcaatg tttttataaa aaagtggttt 1651081 ttaatgattt ttttaatttt gttttatatt tcctgtttta accacaaaaa aaccgcagct 1651141 gagctgcggt tttatgtatc gactgctttt aacaaaatct gtttgatgct tcaaggaagc 1651201 attacatctc ttcgaagtat tctttataat agccgccgac tttattcgta ttgtcgacca 1651261 caaagagaaa ctcctctgtt tcatttttta cttcatattc ttttcccggc gttaaaacgc 1651321 ggtttacgat atattttttt gcgtttgtct gcacacactt tactttttta atggtttctt 1651381 tttcaagcca atttttatga atcatgatga aatctccttt tcttatctat aagcttattg 1651441 tagctttttt cttttgtaaa ttgcaatatc ggttattcat tgattttgcc ttgatttcta 1651501 ttatagaatg tttgtatacg cttacgtttg aagcaactat cacagcttat ttctgctatt 1651561 caatccagga atcaatgtgc tatcaccaag aatctcagaa cagaccataa aaaatgactg 1651621 gaggtttgtt acggatgagt tctttaacga tgcaagtgac gaaaaggctg gagacatttt 1651681 tacagggaac aaagaagctt tatattgacg gaaagtttgt tccgagtgcc tcaggggcaa 1651741 cctttgacac tccaaacccg gcgaccggcg aaaccttgat gacgctgtat gaagcccagg 1651801 ctgcggatgt ggacaaagct gttaaagctg cccggaaagc ctttgaccaa ggtgaatgga 1651861 gaacaatgtc tccagcttcg agaagcagac tgatgtataa gctggcagac ttaatggaag 1651921 agcataaaac tgagcttgct cagcttgaaa cacttgataa tgggaaaccg atcaatgaaa 1651981 cgactaatgg agatattccg ctggctattg agcatatgcg ctattacgcc ggctggtgta 1652041 caaaaataac aggacagacg attccggttt ccggcgctta ttttaattat acgcgtcatg 1652101 agcctgtcgg tgtcgtcggc cagatcattc catggaattt cccgctcctg atggcgatgt 1652161 ggaaaatggg cgcggcactt gcaacaggct gtacaatcgt cctcaaaccg gctgaacaaa 1652221 caccgctttc agctctttat ttggcagaat taattgacca agccggtttc cctgccggtg 1652281 taatcaacat catcccagga ttcggtgaag atgcgggaga agcgctgacg aaccacgaag 1652341 cggttgataa aattgccttt accggttcca ctgaaatcgg aaagaaaatc atgtccaccg 1652401 cagcgaaaag cattaagcgt gtgacattgg agctgggcgg aaaatcgcct aatattcttc 1652461 tgccggatgc gaatttaaaa aaagccatcc cgggcgcttt aaacggtgtg atgtttaacc 1652521 agggccaagt ctgctgtgcg ggctcacgtg tcttcattca taaagaccaa tatgatgaag 1652581 ttgttgatga aatggcatcc tatgctgagt cactccgcca aggagcggga cttcataaag 1652641 atactcaaat cgggcctctc gtaagcaagg aacagcatga gcgcgttctt tcctatattc 1652701 aaaaaggaaa agatgaagga gcaaaagcag tgaccggcgg aagctgtcct tttgaagcag 1652761 gatattttgt cgcaccgact gtgtttgcga atgttgaaga cgaaatgacc atcgcaaaag 1652821 aagaaatttt cggacccgtg ctgactgcaa ttccgtacga aacagtcgat gaagttattg 1652881 aacgggcaaa ccattcagaa tatgggcttg cagccggact atggacagag aacgtcaagc 1652941 aggctcacta tatcgcggac cgacttcaag ccggaaccgt ttgggtcaac tgctataatg 1653001 tgtttgacgc ggcgtctcca tttggcggtt ataaacagtc aggactcgga cgagaaatgg 1653061 gatcatatgc cttggataat tacacagaag tcaaaagtgt atgggtaaac cttgaagact 1653121 aacatgtatg tttaaaaaac tgctgcctgc cagcagtttt tttctttctg taatggcagt 1653181 aaaagacgct gaatatatat gcttctgaag gagttgagcg tgatgggcac acttcaggag 1653241 aaagtgaggc gttttcaaaa gaaaaccatt accgagttaa gagacaggca aaatgctgat 1653301 ggttcatgga cattttgctt tgaaggacca atcatgacaa attccttttt tattttgctc 1653361 cttacctcac tagatgaagg cgaaaatgaa aaagaactga tatcatccct tgcagccggc 1653421 attcatgcaa aacagcagcc agacggcaca tttatcaact atcccgatga aacgcgcgga 1653481 aatctaacgg ctaccgtcca aggatatgtc gggatgctgg cttcaggatg ttttcacaga 1653541 actgagccgc acatgaagaa agctgaacaa tttatcatct cacatggcgg tttgagacat 1653601 gttcatttta tgacaaaatg gatgcttgcc gcgaacgggc tttatccttg gcctgctttg 1653661 tatttaccat tatcactcat ggcgctcccc ccaacattgc cgattcattt ctatcagttc 1653721 agctcatatg cccgtattca ttttgctcct atggctgtaa cactcaatca gcgatttgtc 1653781 cttattaacc gcaatatttc atctcttcac catctcgatc cgcacatgac aaaaaatcct 1653841 ttcacttggc ttcggtctga tgctttcgaa gaaagagatc tcacgtctat tttgttacat 1653901 tggaaacgcg tttttcatgc accatttgct tttcagcagc tgggcctaca gacagctaaa 1653961 acgtatatgc tggaccggat tgaaaaagat ggaacattat acagctatgc gagcgcaacc 1654021 atatatatgg tttacagcct tctgtcactt ggtgtgtcac gctattctcc tattatcagg 1654081 agggcgatta ccggcattaa atcactggtg actaaatgca acgggattcc ttatctggaa 1654141 aactctactt caactgtttg ggatacagct ttaataagct atgcccttca aaaaaatggt 1654201 gtgaccgaaa cggatggctc tgttacaaaa gcagccgact ttttgctaga acgccagcat 1654261 accaaaatag cagattggtc tgtcaaaaat ccaaattcag ttcctggcgg ctgggggttt 1654321 tcaaacatta atacaaataa ccctgactgt gacgacacta cagccgtttt aaaggcgatt 1654381 ccccgcaatc attctcctgc agcatgggag cggggggtat cttggctttt atcgatgcaa 1654441 aacaatgacg gcggattttc tgctttcgaa aaaaatgtga accatccact gatccgcctt 1654501 ctgccgcttg aatccgccga ggacgctgca gttgaccctt caaccgccga cctcaccgga 1654561 cgtgtactgc actttttagg cgagaaagtt ggcttcacag aaaaacatca acatattcaa 1654621 cgcgcagtga agtggctttt cgaacatcag gaacaaaatg ggtcttggta cggcagatgg 1654681 ggtgtttgct acatttacgg cacttgggct gctcttactg gtatgcatgc atgcggggtt 1654741 gaccgaaagc atcccggtat acaaaaggct ctgcgttggc tcaaatccat acaaaatgat 1654801 gacggaagct ggggagaatc ctgcaaaagc gccgaaatca aaacatatgt accgcttcat 1654861 agaggaacca ttgtacaaac ggcctgggct ttagacgctt tgctcacata tgaaaattcc 1654921 gaacatccgt ctgttgtgaa aggcatgcaa taccttaccg acagcagttc gcatagcgcc 1654981 gatagcctcg cgtatccagc agggatcgga ttgccgaagc aattttatat tcgctatcac 1655041 agttatccat atgtattctc tttgctggct gtcgggaagt atttagattc tattgaaaag 1655101 gagacagcaa atgaaacgtg aatcttatca agcggagatg ttcaattggt gtgaagccct 1655161 gaaagatcag attcaaaagc gaggtcagct tgaccagttt gaagatcaaa tcgacaagat 1655221 gattgaggct ctggaagatg accaaacaac agaagaagat tggtataaac aggccgctgc 1655281 cctttatcgg gatattacag aatcagatga tacaagtgaa agacgcgctt atgtccctat 1655341 agggaaacac gtgctgccaa agcttcctta caaatactcc gccttagaac cttatatatc 1655401 acgcgatatt atgatccttc atcatacaaa acatcatcaa agctatgtcg atggcctgaa 1655461 caaagcagaa tcagagctta aaaaagcgag agcgacaaag aattatgact taatcactca 1655521 ttgggaaaga gagcttgcgt tccatggagc aggccattat ttgcatagta ttttttggtt 1655581 ttctatgcat ccaaacggaa aacggcgtcc tacaggggca ttgttccaaa tgatagacct 1655641 ttcatttgga agctattccg cttttaaaga acattttacc caggcctcta aaaaagtgga 1655701 aggcgtcggc tgggccattc tggtctgggc acctcgatca ggacggctgg agattttaac 1655761 ggcagaaaaa caccagctct ttagccaatg ggatgtgatc ccccttttac cgcttgacgt 1655821 atgggagcat gcctactatt tgcaatacaa aaatgaccgg gccagctatg tcgatcactg 1655881 gtggaatgtc gtggattggc gcgaggctga aaaacgtttt gagcaggcaa aagaagtcgt 1655941 ttggaagctc tattaaaaaa agcccccttt cctcgggggc ttcgtgtgtt aaaaaatacc 1656001 tatcacatgc aaaaacacga tgatgatggc aacaggagat agatatcgaa tgagcagcag 1656061 ccaaaccgca aaccactttc gtttgagatt ggaaccgctt ttcagctcgt caaacaaatc 1656121 ctgtttcggt atttttagcg gaacaaaaat cgaaatcagt aacgcaccta acggcattaa 1656181 aatattgctc acaagatagt cagccgcatc aaaaatagac agatgaaata tagtgacgtc 1656241 acttaagaca ccgtatgata atgcagacgg cacaccgaca ataaaaatag caataccgcc 1656301 taaccaagcg aatcgttttc tcttattgat atcgcctttc gacagtactg cgaccaaaat 1656361 ttccagcatt gaaaaagcag atgtcaatgc agcaaataaa aatagaagta aaaatgctaa 1656421 taaaaagata attccgaacg gcatttgatt aaacacagtc ggcagaacgt taaataacag 1656481 aaccgggcct tggtctggct tgaggccgaa tgaaaataca gctggaaaaa tcgcaattcc 1656541 ggccattaca gcaacaagca tgttcataac agttacagat acagcggact gtaccagatt 1656601 ttcctgtttc tctaaataag cgctatacgt taccatgaca gatacaccga cacttaataa 1656661 gaaaaaggat tgtcccattg catataaaat ggtattggca tcaattgcag ttaaatcagg 1656721 catgaggaaa aatttgattc cttccatcgc gccatcaagt gtaaccgaac gcaccattaa 1656781 aatgatgaat aatagaaaaa gcgccggcat taatacttgg cttgcttttt caattccgct 1656841 gcttacccct tttgcaacaa ctaaaattgt taccaccata aagagcagct ggcctcctac 1656901 agccaaataa ggatttgaaa tggtacttgc aaatatcgta tcaaaaccag atgtttgcga 1656961 taaaccgcca gtgaagcctt ttataatata aattaaaatc catccgccta cgacactgta 1657021 gaaagataga agaataaagc acgtcaccat gcctaaataa ccgatccaat gccacttcgt 1657081 tcctggagca agtgttttat aggactgaac ggcatctttc tgtgttcttc tgcctatgat 1657141 gaattcacct aacaataaag gcagtccgat taaaaccgta aataaaataa aaataagtaa 1657201 aaatgcgcct cctccgctgg ttccggcaac atatgggaat ttccatatcg caccaagccc 1657261 gatagctgat cctgccgcgg ctaaaataaa gccgagcttc gaagaccatt gatttgcttc 1657321 cttcaccgta tcactcctat ttgatctaac cattataaag gttcattgta agaatatctt 1657381 cctatatagt caagaacatt ttaattagtt tacatcatat atctatagac atctgccaaa 1657441 aactaatatt gaattattca gaaaattatt tataataaga gaatgttatg aaatttgtaa 1657501 gaatttctgc tgaagttctt gataagtgtg ttaggagtgt ttttatggac atcattagaa 1657561 aaataagcca ttttgcagga caaacctttg gcatatgggt cattgttttt gcagtgctgg 1657621 gattttcttt cccatcttta tttacgtgga tcagttctta tattacgatt tttctcggca 1657681 ttatcatgtt tgggatgggc cttacactgc aagccgatga tttcaaagag ctggtcagaa 1657741 agccttggca agttattatt ggagtaatag ctcagtatac gatcatgccg ctcgttgctt 1657801 tcggcctcgc atttgggctt catcttccag ctgaaatcgc agttggtgtt attcttgtcg 1657861 gctgctgtcc cgggggaact gcatctaatg ttatgacatt cttagcaaaa ggaaatactg 1657921 ccctttctgt tgcggttacg acaatttcta ccttattggc acctgttgta acaccgttgt 1657981 tgattatgct gtttgccaaa gaatggcttc ctgtctcgcc ggggtctttg tttatctcaa 1658041 tcttacaggc ggttttattt ccgatcattg caggtctgat tgtcaaaatg tttttcagaa 1658101 aacaagtggc aaaagccgta catgcccttc cgcttgtttc tgtcattggc atcgttgcga 1658161 ttgtctcagc tgtcgtcagc ggcaatcggg aaaatctgct tcaatcgggg ttgctcattt 1658221 tttcagttgt tatcctgcat aacggtatcg gttatttact ggggtttctt tgtgcaaagc 1658281 ttttaaaaat ggattacccg tctcaaaaag cgattgcaat cgaagtcggc atgcaaaact 1658341 ccgggcttgg ggctgcactt gccacggctc atttctcacc gctatctgcc gtaccaagcg 1658401 caatattcag tgtgtggcat aacctttcag gttctatgct tgcaacatat tggtcaaaaa 1658461 aagtgaaaaa gaagcaagct ggatccaaaa gcagcaatct atcactttaa atatgcatca 1658521 aaaagggtac atcactttat cgtgatgtac ccttttttat tatccttcta ataaaagctg 1658581 ttcaggatct tccagtaaat ttttgattgt cacgaggaaa ccaaccgctt ctttaccgtc 1658641 tacaattcgg tgatcataag ataaagcgat atacatcatc ggacggtttt cgaaacgctc 1658701 ttcatcaatg gctacagggc gcagctgaat cttatgcatg cccagtatac cgacttgcgg 1658761 gctgtttaaa attggagttg acatcaatga accgaaagtc cctccgtttg taatcgtgaa 1658821 ggagcctccc tgaagctcgc taagggttaa tttattgttt cttgcttttt tcgcaagctc 1658881 gccgatctct ttttcgattc ctgcaaatgt caggcgatcc gcatcccgta caaccggaac 1658941 gacaagacct tcatcagcag caacagcgat tccgatatcg tagaattttt taacgatcaa 1659001 ctcatcgcct tgaatttctg cattcaacag cggatatttt ttcaatgcag ccacgaccgc 1659061 tttcgtgaag aaagacataa agccgagctt cacttcattt tgctcaaaaa attgatcttt 1659121 gcggcgtttt ctgagattca tgacagccgt catgtccact tcattaaatg tagtcagcat 1659181 cgctgatgtt tgctgtacct ctacaaggcg ttttgcaatc gtttgtctgc ggcgtgacat 1659241 tttttgcact tcaacaggtt tgtcaaagct ttgctgtgct ttttgagcct gaggctgctg 1659301 cttttgctga ggagccggtt ttgatgccgg tttttcgtac gcttcgacat cctgcttgcg 1659361 cactcttcca agcggatctc cagttggaac ttgagacagg tcaattcctt tttctctcgc 1659421 aagcttacgg gccgacggag aagcgatcgt tcttgatttt gcttcagatt gtgcttcctc 1659481 gctcacctct tgtgcagctg gttcagcctg tttctcttct tttacgcttt ccttgctttc 1659541 tgttttctct gtaggagcag gggcagaact ttcacccgcg ccttctgaaa tcgtaccgat 1659601 aatttctccg acctggacgg tatcacccga atctttcaat acctcttgaa gtacacccga 1659661 ttcttctgct gtcaattcaa cattcacttt atccgtttct agttcaagca gatattcacc 1659721 ctgttctaca tagtcaccag gctgctttaa ccattgggct attgttcctt ctgagattga 1659781 ttctgctaat tcaggtacct taatttccgc cattttttca tttccccctt agtttttgcg 1659841 agtcaagcta tcagatacaa tacgttcctg ttctttttta tgaactgtcg gatctccctc 1659901 tgcagggctg gatcgtcttc ttcgtccaat atattgaacg cttactccct ctggtgcaat 1659961 ctctgtcaaa tacgggctga tataacccca agcccccatg ttctgcggct cttcctgcac 1660021 ccaaacgatt tctttcaggt tcggaagttt tgcaaataat tctttgactc cttttgccgg 1660081 gaatggatac agctgttcga ttctcgcaat gtgaagccac tctttaccgt cttctaactt 1660141 attaaaatga tcgctaatgt ctatagacac tttaccgctg gataatacaa gtctggttac 1660201 tttttcatag tcatgagaaa gtcccgactg ttcataaaca ggctggaagc ggctttcgct 1660261 gagctcctgc acttccgaca ccgtatttgg gttgcgaaga aggctcttcg gcgtcataat 1660321 gacgagcggt ctgatttctt cacgaagcag cattttagcc tgtcttctta aaatatggaa 1660381 atactgtgcc gcgcttgtca ggttggcaac cgtccagttg ttttccgctg caagctgcag 1660441 gaatcgctca attcttccgc ttgagtgctc aggcccctgt ccctcgtaac cgtgcgggag 1660501 cagcatgact aatccggatt tttggcccca tttcgcgcgt ccggcagaaa taaattggtc 1660561 aaaatacact tgagcagcgt tggcaaaatc tccgtactgt gcttcccaca aaacaagcgt 1660621 ttccggtgaa tgcacgttat agccgtattc aaaaccgaga accgatcctt cagacagcgg 1660681 gctgttatga acagcaaatg atgtgctgca gtcagataag tgatgaagcg gcacaaattc 1660741 tttgcccgtc tcactgtcat gaagcacaag gtttctttgg gcgaacgttc cgcgctcgga 1660801 atcctgtcct gttaaacgaa tcggtgttcc gtctttcaaa attgaagcaa acgcgagtga 1660861 ttctgccaaa gaccattcca cttttctgtc atcatcgaac gccttggcgc gtctttctaa 1660921 aatgcgcttt agcttgccga aaacattaaa tgactccggc cagttgatca attcgccatt 1660981 cagcttgcgg agcacatcaa aatcaatcga agtgtccaca tctgggaaac cgtttgatac 1661041 aggctctgga agttcaattt cacaagcagt gtgttccttt ttagacggaa ctttctgata 1661101 tgcatcctca atgcgcttcg ttaccgattt ttcgatgttt tgaacgactt cctcggtaac 1661161 cacgccttct tttaccagct tttcagcgaa aatttgtttg acggtcggat gctttctgac 1661221 agcatcatac agcattggct gagtggttga cggttcatcc atttcgttgt gtccatagcg 1661281 tctgtacccg atcaaatcaa tcagaaaatc cttgttgaat gtttttcggt attcgaccgc 1661341 aaacttaaca gctgaaagac aagcttcagg atcgtccgca ttcacgtgaa caatcggaat 1661401 ttcataaccc ttggccaggt cgctggcata ttttgtcgat ctggattcag cgctttctgt 1661461 tgtgaatccg atcatgttat tggcgataat atgaatcgca ccgcctactt gatacccttt 1661521 taaagagctt aaattcaatg tttcagctac aattccttcc ccagggaatg cagcgtctcc 1661581 atggattaaa atggccagcg attttgtttc atcttgtacc gggtatccgc tttgtgttcg 1661641 cgtttcctgt gccgctcttg tgctgccttc aacaatcgga ttgataaatt ccaagtggct 1661701 cgggttgttc gctaacgtaa tgcgcgctga ttttgtttca gcgtcttgaa gctcccgatt 1661761 cgcccccaaa tggtatttga catcccccgt ccatccgtag ctgattccaa tggatccctc 1661821 agacggtaca agatctttgt tcggcgcatg ctggaattca gagaagatga tttcatacgg 1661881 tttgccgagc acatgtgcca agacattcag gcgtcccctg tgcgccatcc cgatgttgac 1661941 acttgtcgtg cctgatttga cagattgtgc aataatgtca tcaagcactg gaacaagagc 1662001 gtccagaccc tcaatggaaa agcgcttctg cccgacgaat gtgcggtgca aaaactgctc 1662061 aaagccctct acttctgtca atctttccag cacagctgac agcttttcag ctgagttctt 1662121 ctggaacagc tcgccagatt caatctttct tgtcagccac tcgcgctctt tgaagtcatg 1662181 cacatggtca aattcaaaag agatggttct tttatacgta tttcgtaaat actgaatggc 1662241 ttctaaaccg ttcgaaatgt ttttaggagc gtctttgcag atgacagacg caggtattgc 1662301 ttttatttcc tcttctgtta gcccgtaatc ggataatgga aaaagttcgc tctttttctc 1662361 atcctttctg agcggattga cggaagcgtt caaatggcca taggttcgga tatcttctgc 1662421 aagtctgact gcggatgcga tcttttgaat cagatcggct gtaacacgtc ccttttcttt 1662481 tgttcccgag gcctctttta tatcgcttgg cggagcaccg agctcgtcga acatttcctt 1662541 caaatccggg tcaatgctgt tcggatcctg ggtatactga tcgtaaagct ccagcgcata 1662601 gccgaggttc ggaccgtaaa aatcttccca attcattcgt tgtttcatac tattttgaaa 1662661 catttgaata ttacccccaa cttaaataat caagtgattg attcactatc ttgaaataac 1662721 tttcgaacgc tgtgtccaaa attatgtaat aaaaacgctt ccaacgatat tttaccactg 1662781 tttgcaattt gattctacct tgattgttca caaaatagta aaaaaccttt ataaaaaaca 1662841 aaaaatttaa tcattcgaaa aaacaaacgc caaaaagcat aggattaagg gctatcctat 1662901 gcttttatga agcagttttt tcagcagcgg atacaaaaca tccggtagct gatcaacatc 1662961 cgggacaaat atactgaatt ttccgtacat atcctggatc gtcttcattt gcgattcttc 1663021 tatttctgag ttggagagaa aaacatttat cacttctatt cctctttttc gggcttcgat 1663081 aaccgcctca cttgtatcaa cgatcccatt ttgttcgtag ccaaatgcgg ccggctctcc 1663141 atctgagaaa acaattaaga acttttgcgc ctcgctgcga tgcagcattt ttttcgtcat 1663201 ctgcctaatt gcgtacccgt cacggttatc ttcttctggc tcaagctgca taatggccgg 1663261 tccagaatct tgtcttaatg atgattggaa gggaataacc gtattgaaat agtttggctg 1663321 gcttttttcg gttgcatcat ttgtgtcctc ccaaaaaccg acaatctgat gcggaaccgc 1663381 taccgatttc aacgcttcgt gaaacagcac gattcctcgt tttgtttcgt ccattttgtc 1663441 gaacatgctg gcggaacaat cgaccagcaa tgtaaaaact gcgtcgattt ctgaagatgg 1663501 ttcttgcttt ttgtagaaca ggcgcggatt tcgctcagtg aagtaacgaa gaagcttatt 1663561 gttcagtctc ccggcatgaa ggtctgttct cggcaatgtt tttttatgct ccagcgtttt 1663621 ttgaatcatt tgtttcaaac gcttttgata cgattcaatc gtttttgcct gctgtttata 1663681 agaaagctct tcttcactgg ttgccggctg cggttcttta taaattggaa atgcatattt 1663741 attttctttg ccgtcagcca tacccgctcc gttcggctgg tctttttggg actccagcgc 1663801 ttccagcttg gaatagtctt tccgtttcgt ttgtctggct gatccttgaa cagagccaag 1663861 ggcctgatct ccatcgtcgc cttcccttga agcatctttt cctaaatctg attttgcgcc 1663921 gtgttcaata tcaaattgaa ggaagctttt agacggtgct tctgtttccc ggtgccatgt 1663981 cggcatttct tcttcatgga tatcctcatc accgtctgat tgttttggaa gcgtgatgtc 1664041 atcactcagc ttcggcgctt ttttctcttc ttcaaataac ggctgttctg cagcttttgc 1664101 gtaatcaagc tcaggcaaaa agaagtaggt gttcaacatg tctttatcga gtacctcttc 1664161 aagtccgtcc atgaggtcct caacaatttt cagaacctgc cgtgtcgaat ctgcttcata 1664221 cacacgcaag agctgctgct caataaacgg gcgcatcaga tcgatatctt cacgcatgga 1664281 tggaagggtc tcgagcggcg attccgctgt gagcttgaaa tagatcgcgc aaaagagcgc 1664341 atcggtaaaa atgcttcgtt ccaaatttaa ggtcagctgg gttgagaaat gttttctgta 1664401 catgtctttt cgcttcgcaa atacatgttt cgtacccggg cgctcacgtt tgatgcattc 1664461 ttcgatccta atgtcttcaa gcagcataaa gagctgcttg gcaaaacttt taaacgtaag 1664521 atggcgatgg atatcattca aaaagttcgc aaactcatgc agcgagctat atcttgttcc 1664581 gactgaacgc aggtagacgt cgcttttcag acccgcttcc atgtcctcag ctgccctgtc 1664641 tttccaaaag tggctcatat agattttctt ttcaaatgga ttgtaatagg actgaacgcc 1664701 atactccact tctaccgctt cactcttggt gagtgttttg gccaaatcag tcagcatcat 1664761 aaataaaaat gaatcaatcg tgctgtcgtt aaatttgata aatttcatcg cagccccctc 1664821 attcaaacag agtttctgca atatttcgga cagccgcttt ttcccgatca tcatcaagct 1664881 tttctacaat tccccgctca atggcacgac gcggcggaat ataagcagct aaatcacatg 1664941 tatcgattaa agctctgatg gatgccgctt cttcagacac ctgtccgtta ttggcctgaa 1665001 cgatcaagtc agaggaaagc gtgataaatc tgtcaatcaa tttctcgtct ttcaaggctg 1665061 actgagacat gagcacttgt ttcagcagct cgcctttaat ataaggcaca tcaatgatga 1665121 caaaacggtt tttcaacgct tcattcagag gaacagttcc gacatagcct tcattgatgg 1665181 ctgcaatgac tccgaaaccg cttttagccc gtatgacctc gcctgtaaac ggatttgtca 1665241 tcatttttct gtaatctaat acaccgttta gaataggcag tgtttccggc ttcgccatat 1665301 tgatttcatc tatataaaga aaatggcctt ccttcattgc ctttgtaaca ggtcctgaaa 1665361 caaactcgat tgttgcctgg ccagattgat tttcaatcgt tttataaccg accaatgcct 1665421 cagcgtccaa gtcgactgaa cagttgacgc tgtgcatcgg tttatgaaaa tagctggaca 1665481 atgtttctgc cagctttgtt tttcctgaac ctgtaggccc tttcagcagg acatttttcc 1665541 ccatggctaa tgcaataatg gcgtcaaata aaatggcttc atcctccgcc tcatagcctg 1665601 atgttcctat aagcgattga aactctgggg aaataggctg ctctttatat gataaaagct 1665661 tttgttgtat atcttccggc aatgttaagt gctgtagttg agttgtcata gacagattcc 1665721 ctttcctatt catattccat taacgagtat actaaaaaag cccctgtatg ctcaatacaa 1665781 aagggcctgg atgatattac tgcttctcgt tatttcccaa aagggctccg cagacaatac 1665841 gcgcaccgga attgccgctt gggtttgtca gataatcgtc cgcttgttca tgaataataa 1665901 atgcacttcc gtcctcgtcg agaatattta gtttacttcc ttttttcagt gaagtgtcag 1665961 gcgcattcat tatgacatct acctttccat cagcaccgac ttcaaggttc ggcagatctc 1666021 cggcatgatg ccccatcgga ttattaaagc cgtgttcttt gttcagtgga ttaaagggac 1666081 cgcccgctga ttcaaaatcc ggcctgacac aagaaccttt ctcataaata tgaaaaccga 1666141 gagaagcacc tggacgcagg ctgtttgcgg aaatatgaat atcgaggcct tcatcatctg 1666201 attctttgat ctctataaaa ccgactgctt tcccttcacg attgaccagc tggacatgat 1666261 gaccaaacgc tgacgtttca accacttttt tttccggcac ccggttagga gggtctggag 1666321 gttttttttg tccgcatccg gcaactccca gtgccgtcag catcatcaac agcaagagac 1666381 ggtgcatact gtctccccct tgttttttct aacagtgtgg tcaatcattg tctggtataa 1666441 acaaaaaagc ctataaaagg ctttttgtca tactcatttt taaaaataac ttcttgcgcc 1666501 caagtaccgc tgtttccaat acgaattgct gagattggaa atgtcgacgc ccgatgagct 1666561 tgcatgaata aaatcaccgc cgcctagata aatccccatg tgagacgggc cggatttata 1666621 tgtggtaaag aagacaaagt ctcctactga cggctggctg actttctgca tgacattcca 1666681 ataccctgcc gtactcaatc ttgatataga tgatacatta ttaatgaggt aataaatgaa 1666741 gccgctgcaa tcaaaaccgg caggcgtgtt tccgccccat cggtaaggca ctccgacata 1666801 ttttttcgct tccgttatca ttctgtcaat cttcgaacct atttgaatgt ttgaccctga 1666861 gttatctttt ggctttgttg gctttgtcgg atttgaagga ttagattttg atgctcccga 1666921 aatagtcaga acctgcccga tttgcaacac atccgatgat aaattgtttt tatcacggat 1666981 gctttggaca gtgactccga gccgatttgc aattttccac agcgaatcgc ctgcttttac 1667041 cttgtacgtc gttgtttttg agggattgga gtttgacggc tttttggaac cgctgtttcc 1667101 gttcttaggt gaactgcttc cttttatttt gagcacctgt ttaggataaa gtgtatctga 1667161 tgttaagcca tttaaggttt ttaattcggc tacagtcata tttaagctgt ttgcgatttt 1667221 ccacagtgag tcaccaagct tgaccgtata tgtacttttt gaagaacctg aagaattgga 1667281 accgctgttt ttctttgatc catttgatcc gcttgaactg cttgtccctt tgatcttaag 1667341 cttttgcccc ggacgaatca ggtcactgct caggctgttt aagcttttaa gctcagaaac 1667401 actcatttta tgatttttag caatcatcca tagggaatca ccatatgcaa ctgtgtatgt 1667461 tgatgttttg cttgaattag atggggatgt cgtgcttttt ttgctgcttt caggaacctt 1667521 aagactttgt ccgacataaa gcaccgttga tttcaatttg ttttcggatt tcagagctga 1667581 tattgtcgta tcatactggc gggaaagttt ccaaagagag tcaccgcttt ttacttttat 1667641 cgtttttgct tccgcgggtg ctgcggccat cgacgaccca acaactgcag aaacagccaa 1667701 gccggctaca atcttctttt tcattcattc aacctcctaa actgtttttt tgcaaaaaca 1667761 gctagtattt tgtttccaaa aatggcacac aactgtttta tcgtcaattt ttcagcaagt 1667821 taaacccttt tcaaacattt ggcgcagcat tttcagcatc gttcgacctt taaaccttca 1667881 aataaacatc taacatttta cataagcacg atatgttttt cgaaagtcta aggaactatt 1667941 taagcgaggg taaaaatgat ggttttctat tgatgaacga agcagtttct cctcctttct 1668001 tgtctatttt tctaatcaat tctctatcgg cgtgtcaaat cccttcctct gcattcttat 1668061 gaaatggcaa aaagcctgtt ctttcgataa gaacaggctt ttacactatg catttgctga 1668121 ttgagttttt tgttttacag cttcaagaat gctgtcggct gcttttttag agccgcctgc 1668181 cgctttcagt gattgtccaa tttcttttgc cttttcagca tacgaacgat tattcattac 1668241 ttcttgtatc gtctctttca gtaggctttc agacaattct tcctttttaa ttacttttcc 1668301 tgcgccgact ttttctacct gatctgcgac aacaaattgg tcgcctccca tcggaatgac 1668361 aacgagcggg gtttcaaaat acaaaccttc acttgtgctg ttcattccgc cgtgggtcac 1668421 aaataagctg gctcttttca agatctcaag ctgagggaca tacgggcgta caatgaaatt 1668481 ctccggaatg tcgtttaact cacttgtttt aatatgcttg ccgatggaaa gcacaacttt 1668541 accgtcaaag tccttacaca cttcaaggca ttgattaaaa aactgctttt gattattaaa 1668601 aatggttccc attgaaataa acagcacgtt ttcattgtca atctgatcaa atgggaaatc 1668661 attgtttccg gctctttctg taatggaagg accgacaaat acatatcgct cgccaaattg 1668721 ctcagccagt ggctgaaatc cccttgatgt aaagacgatt gtcaagtcac catcagctaa 1668781 aaaaacatca aatggcttct tgatctctgc ttgaaaatca gcatttaacg tttctgcaag 1668841 ctgctggtat gattcataat gaggcgaatc ttcaagtgat cctttcatgt acgctcccat 1668901 catttccttc gcaaattcct cattcatcgc aaaggttgta cacaatgaaa atcttggcag 1668961 cttcagcatg ttggcaatga ctttacccgc gagaagatgg tgatcatata tgacataatc 1669021 atacgattca tgtttgactt cctcataaat atgagtcgcg atatccttac aggctttcaa 1669081 aaaagcgcag agcatttctg tgaaatctct ttcttcatcg ccggttgcgt ttttcccgaa 1669141 gtaatctcct ctgaaatcat gatactcacg aaactctata tcaagagctg tgattttttc 1669201 tttatattcc ttcactgcgt agtacgtaat gttttctccc cgggatttca gctccttcat 1669261 cacaccgata gagggattaa tatgcccttc accggggaaa ccgatcatta atacattagc 1669321 catgcggcag cacccttcct ttgagaattt atgtaatatt ttatacggta ctataaatgc 1669381 ataaacaggt aaagtatttc acttaattaa tattcatcat atataacttt tctaccagtt 1669441 tatattccct gtcttcaaga caaaaagcat tcagcttgaa gcgaatgctt taataaagat 1669501 gcgaattcag tcattttgtc tcatgatagg attcttaatc aggccctttt tattattttt 1669561 acgttcttgg tgaaattaac ggatataata caccgtcttt ggcaaacgac atcttccctg 1669621 tttcctctga aaccacgagc accagtgcat ccgtatagcc cgacatacca agagccgccc 1669681 ggtgccgggt tcccaaatgg atatccactt ccttcgtcgt cagcgggagc acattggctg 1669741 ctgacacgag tttgttttcc ctcactaata aagcgccgtc atgaagaggg tttccgggaa 1669801 aaaagatgct ttcaattaat gaagagctga tctcggcgtg tagggaggtg cctttttgaa 1669861 taaaacgttc aaccgggtct gctctttcaa tcacaattaa agctccatgc ttatgttccg 1669921 ataaggcttt aatcgccttg gccagctcaa taaatgccgg cgtaaattcc tcaatgtatg 1669981 attgcaaata aaaggaggat gcaatcccct gcatgtcctg aaaaacgtgc cccaaatcat 1670041 ctaattcaca aaggagacac tggtcttttt cgtgaagcgt tttcaagatt agagatgcat 1670101 cacctaatat ttgctctaag tacacctgta ttttcccctt gaacgcattt tctgatatct 1670161 gctcatagcg catagccttc atctcctgtt taaatttcca acttttcacg aatgcttatc 1670221 ttattgatgc acattctatt ggtaaaggag ggatgtaaag aatggaaatc gaaagaatca 1670281 ttcagtatat ttgcaccttt ttaggcgtga tttcgctttc ttttatttat gcccaaatgt 1670341 ttagaaaaac gaaaccgaca aaaaaagaat aggcccggcg ttcattgctt tttatacata 1670401 aaatgttata atttctctcg ttatgaaaaa gaaacggaga tcaatgtatg aaagaaactc 1670461 aaaacgcccg ggaaaaaatc aaacagctct tgcacatttt aataccgata ttcattaccc 1670521 aagcggggct ttctctgatc acttttctag atactgtgat gtcagggaaa gtcagccccg 1670581 ctgatttagc tggtgtcgcc attggctcaa gcctttggac ccctgtttac acaggacttg 1670641 caggtatatt aatggcggtc accccgattg tcgctcagtt attaggtgca gagaaaaaac 1670701 agaagattcc ctttactgtt ttacaagctg tatacgtggc cgcgcttctt agcatcgccg 1670761 ttttagtgat tggatatgct gcagttgacc ttattcttgg ccgattgaac cttgatattc 1670821 acgtgcatca gattgctaaa cactttttag gctttttatc actgggaatt ttccctttat 1670881 ttgtttacac cgtgttgaga tcattcatcg actcattagg aaaaacgaga gtcaccatga 1670941 tgattacact cagttctctt ccaatcaatt ttgtattgaa ttatgtattt atcttcggga 1671001 agttcggaat gccggcactt ggaggtgtag gcgcgggact ggcatccgcg ttaacttact 1671061 ggtgtatatg catcatcagt tttttcatta ttcataaaaa cgcaccgttt tctgaatacg 1671121 ggatttttct taccatgtat aagttctctt ggaaagcatg caaaaatttg ctcaaaatcg 1671181 ggctgcctat tgggttcgcc gtgttttttg aaacgagcat tttcgcagct gtcacgcttc 1671241 tcatgagcca ttttcataca gtgaccatcg cgtcccacca ggcagccatg aattttgcgt 1671301 ctcttttata tatgctgccg cttagcgtgt ccatggctct aacaattgtt gtcggatttg 1671361 aagcgggtgc agcccgtttt aaggatgcac gctcatatag cttaatcggc atcatgatgg 1671421 cgatcggctt ttctttgttc actgccgcct gtatcctttt attcagagag caaattgcgg 1671481 gcatgtacac ttctgacccc gatgtgctcc ggctgacaca gcacttttta atttatgcgc 1671541 tattttttca gctttccgat gctgttgccg caccgatcca gggagcactc agagggtaca 1671601 aagatgtgaa ctatacgctt gcggccgctt ttgtctctta ctgggtcatt ggccttccgg 1671661 tcggttatat ggtcggtacg tttacaagcc tcggtgcatt cggctattgg attggattaa 1671721 tagcgggact cgccgccgga gcagttgggc tgtttttcag gctggcaaaa ctgcaaaaac 1671781 gttattcgca aaaacaacac atttaaaaga ggtgatcaat catggcaaaa aacaaaaaat 1671841 tattcgagta tctttcccag catgcggaaa ccatcagttc aacatggtat gaaacaatcg 1671901 aggagactga tcccaattcc atttatgcct caacagaccc tgttgtcatt cacaatttaa 1671961 agagccagaa tcttgccttt aactataaaa taaaccgtat ttttatagat gatgaggacg 1672021 tatacttgcc tatactgaaa gaatgggcct ttgaagtcac acaggatcaa gagcatttaa 1672081 aaactcctat ccactatatt attcgggagt ttgtcagagt gagagattta tatgtttctt 1672141 atgtgaaaga atttgtccat ctcaatcaga atactgtgaa aagcgaagaa gccgaagacc 1672201 tgtatcacgc ccttataaaa gcgtttgatc ttgtgattca tatttttata gaagaaatgt 1672261 acaaaaacac aagccttcag cttcaggccc aaaaagatat gattactgaa ttgagcgctc 1672321 cggtcatcgt gctgtttcac agcgtcggac tgctgccttt aatcggagat attgatacag 1672381 tccgcgccaa gctgattatg gaaaacacac tgcatcaatg tgcgaaaaaa aaggtgacac 1672441 aactgtatat tgatttgtca ggagtagctg tgattgatac gatggttgcc catcagctgt 1672501 tcagtctgat tgaggcgctt cgtttaatcg gtgtttcttc aactttgtct ggaatccgtc 1672561 cggaaatcgc gcaaacagcg gttcagctag gtttgtcttt cgaaggtatt tccttgagat 1672621 ccactctcgc ttcagctatt gcatcggact taaaattaaa aaaggtataa ggcttaaggc 1672681 cttatacctt tttgattaat cattccattg atacgtccaa tatatttctt cttcaaacca 1672741 tgttgccata acaggttcat tatttttcaa tttctcttca agctctctga gcatgccttc 1672801 tgtttgtgtg cggtgagctc ttaacgcatt cattttaata tcagctactt ctttgatatc 1672861 aagtacgaca tcagcttcgc cgagaacctc ttctctgttg cgggtaatgg ccatgcagat 1672921 tgtacgcgga cggtcttctt tctttttgcg gtataatgca cggataaccg cttccccgca 1672981 tgcatcatgg tcagggtgca caccgtgtcc gggataaaat gtgacaatta aacttggttt 1673041 tacatcatct atgatctctt ccatgatatc agctaaatac tcatcgtctt caaattcgag 1673101 cgttttgtca cggagtccaa gcatccgaag gtcattgata tccatttctt tgcaagcgtt 1673161 gatgagctct tgttttctta gcagcggcaa cgtttcccga ttcgcgaaaa atggatcgcc 1673221 catatttctg cccatttcac ctaaagtggc gcaggcatac gtaacgggaa tgtctttttt 1673281 tctgtttaag gcaatgaggc ctgccactcc atatgattca tcatcagggt gaggcaggat 1673341 tactagtaca tgttctttca ttattattca cccttttctt taaactgtga acggtttttc 1673401 gctgatttgc agagaaatag ccagtttacc gcccggcagg tgtcccgcca ttaataaacg 1673461 gttttcttca tctaccgtgt attcagtcaa gccttcagca taaatccagc cttcttctgt 1673521 tttcaagcca acgcggtaag gcccgttgcc tttgattttt gcctgatgat aagtgacttt 1673581 tgcattgcga atatacgcaa caaccgtcat gttcttttca tttaagtgcg ctgaataaga 1673641 acctgtggtg gtttctaaat ggatatatac agggcggtcc gcatatcgtt ctaaagatgc 1673701 ttgcacatct tcttttatga tcgctttcat gattgctccc ctctttcttc ttttaaatac 1673761 tctgcacgtt ctgtatgtaa tttgaccagc tgatatttca cagccggttc gagctgtgaa 1673821 ttcacaatgc gctgaatcgc ggcaaaatat ttttccagca tcggttttcg gagtcttgga 1673881 tgtgttcgtt tatccaagag ctcaagatca atcgcctctg ctaccgcttc tgcgtcatca 1673941 tgtgcgagag atcggttatt ccaaagtgaa gcataggctt tcactatctc tttatcattg 1674001 tccatcgtct tgctccttta tgtcttacat acatgaaatg attatacata atatatgcat 1674061 cagctgaaaa gccaaaggcc tcaatggctt tttgacgccc gtttccactt cacttgtgaa 1674121 aacgtaaaca agagcagcgc agcccatata cagctgaatg taaaagcctt cgagcttgaa 1674181 aatggctcat ggtaaacaaa cagcccgatc agcagggtaa tggtcggcgc aatatattgt 1674241 aagataccga cttgatacag tggcagccgt ttcgctcctt ccgcaaacaa taagagcggc 1674301 aaagccgtaa acacaccggc caaaaagaga agcagccacg tccctccgct ttctgcaccc 1674361 gctggctgaa catgtccgct gaacagcaaa taccccaatg caatgggcat aatcatgaat 1674421 gtttccagcg ttaaaccgat ggcgctcggc aggcttgttc tttttttgct taacccgtac 1674481 agcccaaagc tgaatgcgag cagaagcgca acataaggaa tggagccgta ttggaacgcc 1674541 gagatgatga caccggctgc cgcaatcgaa acggccacta attgcaggcg attcagtttt 1674601 tcctttaaaa ataaaatccc aaggagcact gatacaagcg gattaatgta atagccaaga 1674661 ctagcctcaa gcaaaaagcc atggttgaca gcccatatgt atacaaacca gttgatcgaa 1674721 atcaggatag aagcaagaaa taaagagagg atccctccgt tctttttcag agagcgcaac 1674781 tcctgccatc ctattttcca ttgccgcaag aaaaaaagta cgatacacat aaaaacaaaa 1674841 gaccatataa tacgatgagc caaaatatca agagccggca gctgttcgag aagcttccaa 1674901 tagagcggaa acaggcccca catgataaat gaaacggctg tgtaaataac gccttttttt 1674961 gtttctgcat gttgcattga tatccctgcc tttctttaga gcatcttata ttatatcacg 1675021 tgaaagatct ggtgggcata tactattttg tccgtgaaga aaggatgtga agacaatgtt 1675081 tgagtggaac aagtactttc ctttccacaa tcaattttct aaagaagcat taaaaaaagc 1675141 tgatccgaaa gaagttgaaa cgtatgtcaa tcgtgtgatg gaaagtgtgt tcggcagtga 1675201 ttatgcggct caatttcctt tccgcgatcc tctcccccaa aaagaacatc ccgccaaacc 1675261 tgatgcaaaa cctgatgtca aacctgatat tgatatattc gaaacagcag accatgtgtt 1675321 tgtaaaggtg ccaatcagcg aagaatggct ggaacaagtg agaatcaaac acacatctca 1675381 cgaattatgg ttggaaaacc tcccaagagc agatcatccg aaaaaagtaa accttccttg 1675441 tttagtcaaa cgcaaaggaa caaaagccgt ctataaggat ggccttctgg aagtcatgtt 1675501 tcaaaagcag caagactaca atatgtccga ggtagaaatc atccgataaa aaacggcctg 1675561 caatcgatgc aggccgtttt ttattaatag aagccgggat atcccccgta tggcacgccg 1675621 gcaccaaaac cgtacggtcc gcctccatat ccataagggc caggaggata ggcataggga 1675681 cgagaatagt taaacagcgc actcccgaga aaaccgccta ataaaccgcc gactagagga 1675741 gcgccaaaca aaaaaggact acgcgccgga tatccggctg gacctgggat tccgcgtaaa 1675801 tacgaatgat gagggtacat gattttttcc tcctttatgt ctgcctatac gtaaagtatt 1675861 cagcaaggaa gaaaaacgat tgggctacgg actgtctatg attgttacat cacaagccct 1675921 gccaataaca cacagccgag ccctgtaacc gaaagaactg ttgtaagcag cgtccaggtt 1675981 tgaaatgttt ctttcatgct caagccgaaa aattccttta ccatccaaaa tcctgcatca 1676041 tttacatgac acgcaatgac actgccggct cctgttgcaa gcaccattaa cgcagggttt 1676101 acactgccag cctccataag cggagctgcc attcccgctg tggtaagcgc agccacggta 1676161 gcagagccta gacacagacg cagaaccgcg gcgatggtcc atgcaacgaa tagcggcgac 1676221 atgtttgttt gacggaaaaa atcagcgaca taatcgccga ctccgccgtc aatcagcacc 1676281 tgtttaaacg ctcctccccc tcctatgatg agcagcatca tcgcaatttg cgaaattgat 1676341 tctgaaatag atctgccgat ttcctgcata gatattttac gggcatatcc catcgtatag 1676401 agtgcaagca acagcgaaat gagcattgcc gttcccggag tgccgataaa ttctataatg 1676461 tcttttcctt ttgaatgttc actcaataat aaagaaaaaa ttgttgccat tgccataaag 1676521 ataaccggga ataaagacgt gacagcactg atcgcaaagc ccggtgtttc atccagctga 1676581 aattctttcc ttggtcctaa ccccgatagg tttccatgct tttgatacgc accaggaaac 1676641 cgtttcatcg caaatttatt aaataaaggc ccggcaatca cagttgtcgg aacagcgatg 1676701 atgattccaa aaagcagcac ctggccaata tgggcaccat atgcaactga gatagcagtt 1676761 ggagcaggat gcgggggcaa aaatccgtga gtaacattta aggcggcggc catcgggatt 1676821 cccagataca gaaaaggcat ttttaattct ttagcaatcg cgtaaacaat cggtatcaac 1676881 agaacaagac cgacttcaaa aaatagggca atcccgatga taaaagaggc aaccacaacc 1676941 gccgcctgta ttcgtttcct cccgaatttg tcaatcagcg taatggcgat ccggtagccg 1677001 cccccagcat ctgagacaag cctcccaagc atcgcgccaa gtccaaacac taaagctaaa 1677061 tgccccagct gcccgccaat tccagtctca attgaaagaa caattttatt gatatccatt 1677121 ccaagtccga tggctactaa aaatgaaacg acaatcagtg agacaaaggt atttaatttt 1677181 actttaataa tgagaaataa cagaatcagc actccgacag ctacaattaa aatcggcatg 1677241 gtacccctcc aaaagtgttt tatatgattc tcgcgacaat gttttggcgc ttttcatgcc 1677301 tagatgaaca gaaagcgctt tcattaataa ctaaaaacgt cttggttata tgattgttat 1677361 cttttgatca actaatatgt tcatactaat ctcctaatca atgactgtca atcgttttta 1677421 tgagcttgtc tcgattacct accgcctaac ccaatgattt attagttata tgttgattaa 1677481 cttttggtta tatgttatgt tttttaaagt tgactgccaa tcattatatc tctccattgt 1677541 ctggaagcaa atgagacaat atgagaacag acggataaca acttcataag aggaggagta 1677601 cacatgccat tattgcgttt tgatgtaatt gagggccgtg atgaaaaatc gctgcaattg 1677661 ttattagata ctgctcacca agcgatggtt gaagcatttg gtgttccgga aagagaccgt 1677721 tatcaaattg tccatcagca tcccgcaaac gagcttataa tccaggatgc gggattaggg 1677781 tttcagagaa ccaaggatat ggtcatcatt agcatgacaa gcaaagcaag aaccgaaagc 1677841 caaaaggaaa aattgtatgc tctgcttgct gaaaggctag aaaaaaaatg cgaaatttcc 1677901 cctgacgacc tcatggtatc tattactgag aatggtgacg cagactggag tttcggtctc 1677961 ggtgaggcgc aatttttgaa tggaaaacta taagatttcg tctccccaca aaaaaaagaa 1678021 gagagagctc caaagaagct ctctcttttt tcataaatgc ggaagtcatc agtatagaag 1678081 catccagcaa tacgaaaaac ctggatctcc ttttatatcc ggtttaaatg ccaattggaa 1678141 gctgactggg ttttggctga aaatataaaa ttttgctgat ttgcataata agatacatca 1678201 taatccccat ttacaatagg ttggatgtta tagcttattg atcatttcct attttatata 1678261 tccccttcat atgcacatga catttttgcc aatccggaaa tatcagtctg acaaatataa 1678321 aaagtcatgt aaacgggtgt gaaccgtact tacatgactc accatggaaa caaaggctct 1678381 ttttcaggtg ccgctttcct tatttctctt cttcacacac tgtgtcacca ggctcgcaaa 1678441 attgatcggc ccatgcctgc atttcttgaa atacagcttg aagcgctgtt cctttttcag 1678501 tcagcgtgta gatgactttg accggcgttt cagggagaac ctgccgttcg acaatctcgt 1678561 tttgttcaag ctccttcaag cgctctgcca acattttttg gctgatcatc ggtattgttt 1678621 ccgttatctc tttaaaccgt ttcggcccat ccattagcac atggatgatc agaccgttcc 1678681 atcgttttcc cagcaatgag aatgcggatt ccattttagg gcacatcgta tttcccataa 1678741 gtcttcatcc cttcatctat tgattgacat gtattcaatg atccattaca ataatctttc 1678801 aagttacatt tagtaagctt ctaacttttc tattatcata ccacgtttat ccgaaggagg 1678861 aaacactatg acgaatactc tggatgtttt aaaagcacgt gcatctgtaa aggaatatga 1678921 tacaaatgcc ccgatctcta aggaggagct gactgagcta ttagaccttg ccactaaagc 1678981 gccttctgct tggaaccttc agcattggca ttttacagta ttccacagcg atgaatcaaa 1679041 agcggagctt cttcctgtag cgtataatca aaaacaaatc gttgagtctt ctgctgttgt 1679101 tgccatttta ggcgatttaa aggcaaatga aaacggtgaa gaagtttatg ctgaattagc 1679161 aagccaaggc tatattacgg atgaaatcaa acaaacattg ctcggccaaa tcaacggtgc 1679221 ttaccaaagc gagcaattcg cacgtgattc cgctttctta aatgcttctt tagctgctat 1679281 gcagcttatg attgccgcaa aagcaaaagg ttatgacact tgcgcaatcg gcggatttaa 1679341 caaagagcag ttccaaaagc aatttgatat cagtgagcgc tatgttccgg ttatgcttat 1679401 ttcaatcggc aaagcagtga agcctgcgca tcaaagcaac cgtctgccgc tttcaaaagt 1679461 atcaacttgg ctgtaaggat atgaaaaacc ttagtccgaa atccggacta aggttttttt 1679521 atacaatcgc ctctttgtac cattcacgag cctgttcagc ttcatgctga gtcagctgat 1679581 ggcccccgtc ctgccagtaa acggaggctg atgccccgct gtcacgcaaa tagcggtaaa 1679641 gctcttctga ttcttccttc gtgcaaagag gatcgtattt cccggcaccg ataaaaacag 1679701 ggagccccgc catatcaggc agctcgatac cccgaatcgg aaccattgga tgatgcagaa 1679761 tagccccttt taacacatct ttataatgaa aaagcaggct tgccgcaatg tttgcgccgt 1679821 ttgaataacc gactgcaatc actcggccgc gattaaactg atgcgtttct gcagcctcgt 1679881 cgataaaatc tttcaattct cttgtccgca ccacaagatc cttttcatca aaaactcctt 1679941 cactcagacg tttgaaaaat cgcggcattc cattttcaag caccgatcct ctgacaccaa 1680001 gcaaatgggc atcagggtct ataaaccgcc ccaatgaaag cagatcgtgt tcattaccac 1680061 ccgtgccatg caacagcaaa agtacgttgt cagatgttcc tttctcataa atatgcttca 1680121 ttataaattc ccccttttaa agttcaggta aaatgtctgt aatttgttgt ctatgtttct 1680181 ccagccattc aggcagtttt aaggaagtcc ctagctcagc aaacgtttca tctgtcataa 1680241 agcccggttc atctgtggca atttcaaata agataccgcc tttctcccta aaataaactg 1680301 atgtaaagta ttccctgtcg agaatttctg acgaaggcag atggttttca gcaataatcg 1680361 gcagccattt cgcctgttcc tttttcttag tccgaaacgc tacatggtgt accgtaccat 1680421 atcctccgac tcctcttttt tcaggatgta aatggacatc aatgacaccg ccgaccgccg 1680481 ctgaagatgc cagtctgaca atctggtctt cttcggccac tttggtgtat ccaaagcttt 1680541 ccgttaacaa ttgtatggtc gcctgcgggt cgtaggaata tagcagcaca cctttcattc 1680601 ccgtaattgc ttcatttgtt gtgatcccgt caggcgtcca ctcgcttttg ccgcttttcg 1680661 catcctccat gatcgccagc ggaaggtctt ctgtatcatc aaaaataaga cctttttcac 1680721 caaacaacgt tttttcctct aggctcagcc cgcttttctc aagacgttcc ttccaaaaag 1680781 acagggagcc tgagggaact gaaaagtaca cccggcccgc ttggcctttt cctaccgttc 1680841 cctgtccgct tccttggaac ggaaaaaagg tcattattgt accgggatct ccgttttgat 1680901 tcccaaagta aaaatgatac gttccgggat catcaaagtt tactgttttt ttaacgagcc 1680961 tgagcccaag cacttctgta taaaatcgca agttttcttg cggatctctg gcgaatgctg 1681021 tgacatggtg caatccttct gttttcattt tctcactcct atttatctcg atttcaagat 1681081 atttattatt ttaaaccttt attgaaaagg atgcaaacca tgtgttttga ttaaataatt 1681141 gaaaaaatca tttttttcta ataattatct tgtgatcttt tcttacaact gctattatag 1681201 tgagcattat catgtttcag gaggaaagta aatggttaaa aaagcactta ttgttattct 1681261 cattcttttg ccattcgttc agctcgcgct tttgccgctt gtgaatcgaa tagaaccgat 1681321 tatgttcggc ctgccgtttt tccacttttg gctgctgctg tggattattg ttacgccgtt 1681381 atgctcgttt ggcatttatc agatgcaaaa aaaagatgga ggacttgaat aatgcaaggg 1681441 aatctgactg cacttctcat tactgctatt attgttttaa ccgttgtctg tatcggcttt 1681501 ctcgccggaa gagacaaatc ctcacgtact tctgtggaag aatggtctgt cggcggcaga 1681561 cgcttcggcg gtcttctcgt ctggttttta gtaggcgctg acctttatac ggcctatact 1681621 ttcttagggt tgaccagtac tgcttttaca ggcggaagtg ttgcattttt cgccattcct 1681681 tattctgtgt tggcctactt tatcgcctac ttcttcttgc caaaactttg gaaagttgcg 1681741 aaaattcata aattaacaac actcgcggat tatgcccggg aacgttttaa cagtaagctt 1681801 ttggcaagcc tcgttgccat cgttggggta ctcatgctta ttccgtacat atgccttcag 1681861 ctgagcggca ttcaagacac gcttcaggtt gccggcactg gctatattaa cgtaaaattc 1681921 gttgtgatca tttcatttat tcttgttgct ctttacacat tcttcagcgg gattaaaggg 1681981 cccacatata cagccatcat taaggacatt ttagtatggg tcattatgct gtttatggtg 1682041 gtgtccctcc ctctcattca ttttaacggc tggacgccaa tgattgacac gttagtgaag 1682101 gaagcgccgc aaatgctgac gataccgtca gaagggccaa aaggcattcc ttggtttatc 1682161 acagcatcta ttgtttccgc tctggcactt tttatgtggg cacatgccgc tacaggtgtt 1682221 ttcacggcga aaagcgctga tgcagtaaga aaaaacagca tgtttttgcc gctttataat 1682281 atcgtgttaa ttttggttat ttttcttggc tttatcgcct ttcttgttct gccggaagat 1682341 acaaatccaa ggctggcgct gctgcatttg attcaaacat cttacggcgg cgtggcacaa 1682401 ggctttgcat atgccactat cgctcttgct tcattaatac cttgttccat tatggcaatc 1682461 ggcgcatcga atttattcgc caacaaccta taccgggatt tgattcatcc gaatgtgtcg 1682521 caaagcaagc tgactcttgt cacacgttca atggtgtttg ttgtcatcgg tcttgcgctg 1682581 ctgtttggaa tgctgttccc gactgcctta gtgacacttc agctattagg tgtatccggt 1682641 atggtgcaaa tcttccctgc gattgctgtc agcctgttct ggaaaaacca aacgaaagaa 1682701 gcaacggtta tcggattatt agccggccta gcggtaacgt ttattgtgta tatcactcaa 1682761 tccgcacatg gcatttatga aggattctgg ggattggccg ccaacatgat cgctgtggtc 1682821 atcctgaatc cgctgttcgt taaaaacgcg ggatccaatc ctgtcattga aggtttattt 1682881 ggcaaaaaac aagacgctaa tccaaatcaa aagggcgcat aaaaaaacca tacgcggcag 1682941 ccgcgtatgg ttttttttac atttcttttt tcagtgtttc aattgccttt tccatttgcg 1683001 tatcattatc agacagcttc ttttgaagtt ctatcattaa tttcgttgtt gtatcgccag 1683061 tcagtatgcc tgtttcattc agcttctctt ttttctggaa ctgtttgacg acagatacaa 1683121 aatcctggtc atacatactg ttaaccttta ccttgtaacc aagtgctttg agcattttct 1683181 gagccacttt gacgtttgtg cctgtatcac ctgatttgta cgttttatct gcgtccaaat 1683241 acggcagctt cgcgtaatca ggcagctctg ctttcacttg aggcttgatg ccttttttgt 1683301 gaatccattc gccatcagca gtcagccatt tggcaactgt cagtttgacg gtagagccat 1683361 catcatattc ttttgccgtt tgtactgtac ctttgccgaa tgtcgtctcg ccgattaacg 1683421 gtacgtttga cgattcatga agggcagcgg ccataatttc ggctgcgctt gctgtaccgt 1683481 catttactaa aacgacggtc ggcttggtca ctttccgttc tttttcggcc ttcatgactt 1683541 cttttgaacc gtttttgtat tcaacctgca tgatgttttt ccctttatca atgaacaggt 1683601 tgctcatcgt aatcgcctgt tccattaagc cgcccgggtt gcctctcaag tctaaaatat 1683661 agcctttggc gccttttttc tctaaactgt caatcgcatc tgtcagctct ttagctgttg 1683721 tttcagagaa agaagtgatt tgaatttctc cgatgttgtt gtctttcatc tctgaataga 1683781 cagtctctac aggaatggta tcgcgcttaa tggaaagatc gatattcccc actcccgctc 1683841 tgttcagttc aagcttcacc tttgtgccct ttttgcctcg gattaaagcg acggcttcat 1683901 ttacattcat gccttttacg ctttttccat ttaccttaat gatttggtcc ctcggtttga 1683961 taccggcttt ttcagcaggt gaacctttaa ttggggatac aataaggatt tctccgtctt 1684021 tctcctctac ttgggctccg attccttcaa aagatgctga aatcgtctcg tcgaatgatt 1684081 tcgcttgctc ttgatccata tatgtagaat acggatcatc cagtgattga atcattcctt 1684141 taattgctcc gtctactaat ttgtcatcat ctgttttttg gtaataatca cttttgattt 1684201 gctcatacgc tttatttaat ttgtcgaact tgctgtctcc tgtgcttgct gatttttggc 1684261 ccaggatact ggaattgccc gtaataaata aagtaagcgc cgaagcgaca actgcagtga 1684321 tcagcacaat aaaaaacagt tttaattgcc gtttcaatta aacaccacct ttttcttctt 1684381 acattattat catggacgaa ttcttattcg tcaactcgga gcagaaatga aagagaaacg 1684441 cccttctttt gcttttcata aacctatgtc tttatacgac atatgataag gaaaaaggag 1684501 gattcgatat tgagccgata tttagaaatg ctgtccttat tcggtgtcgc aggggcgcac 1684561 ccaggcgggc tggctttttc aaaagcggtc ttgcaaaagg ctgcaccctc tccggatcag 1684621 ccgattcttg atgccggatg cggaacaggg caaacggcgg cttatttagg acatttgctg 1684681 tatcctgtaa cagtcgttga taaagatcct attatgcttg agaaagcgaa aaaaagattt 1684741 gcgaatgaag ggcttgccat ccctgcatat caggcggagc tggaacatct cccgttttct 1684801 tctgagtcct tttcctgcgt cctgtcagaa tcggtcctca gtttttcacg cctgacatcc 1684861 tctcttcaag aaatttcaag agttttaaaa cccagcggga tgctgattgg tatcgaagct 1684921 gctttaaaaa aaccaatgcc ccctgcagaa aagaagcaaa tgatggattt ttacggattt 1684981 acttgcttac atgaagaaag cgaatggcat aaactcctaa gatcctatgg ctttcaaaaa 1685041 acagaagcga tgtcacttct tccggaagac atggaatttg aaccaaccac agaaatggat 1685101 ttatcgcaaa cgattgatcc catctattac gatacgcttc aaacacatta tcagctcatg 1685161 cagttatata gtgagtacat gggtcattgt atttttatcg cgtacaagta aaacggcgta 1685221 tcgccccctg ttttcgtcca accttttttt cctatctatc atatgctgat agaaagtcag 1685281 gataggaggg gaacaatatt ggagagatat tatcatcttt gcaaaaacca tcaaggtaaa 1685341 gtcgtcagaa ttacagagag aggcgggaga gttcacgtcg gcagaattac ccgtgtaaca 1685401 agagacagag tttttatagc tccggtcggc ggagggccaa gaggtttcgg ttacggatat 1685461 tggggcggtt attggggata tggagcggct tacgggattt ccctcggttt aattgcagga 1685521 gtggctctgg ctggtttatt cttctggtaa gcatagaaca aatgctagat tcaccagaca 1685581 caatgaagcc cgcttatcta gtgtaagcgg gcttttcatt ttaaattttc ttcacttttt 1685641 caaagtactc ttcaagcgtt aaatcattat cttggatgac ctttgcggct tttttgccta 1685701 catagcgcag atgccatggc tcatattcat atttcgtgat atcttcttta tttttcggat 1685761 agcgaataat aaagccatat ttataagcat tgtcctgcac ccatttcccg tctgccgtgc 1685821 ttccgaacgc ttcatttagc tcaaagccat tgctccggct cgaaatgtcc atcgcaaggc 1685881 ctgtttgatg ctcgctttca cccgggtaag cgaccgcttc ctttgccttc ctttcccctt 1685941 ttaggcttac ttcattgtca aaaatgactt tctgtctgtc atacgaacgg taccctgaga 1686001 cagctgccag ttcatagcct tcctttttgg cagcatcgaa cattgttttt aatgcgtcgg 1686061 ccgcttcttt tctgatgtaa cgtttttgaa tcttttcttc aaaagaaaac tctacatcag 1686121 gtatgacaag atcgctaggt tcatagtttc cgggcagtgc atattgttta ttgacaagcg 1686181 cgagtatatt ttctggattt tgaatggttt ccagaccatc gactttttta atatcattga 1686241 aatactggct ttccaatgaa aactcactgt tttgagtgtt tgattttttg ctgtcagctg 1686301 ttttttgttc tgtttgcttt gtttctgctg tggttttcgt atccttttga gcatctccgt 1686361 tcgacatgct gcagccggct ccgactattg ccgttacact cagagcggca gccagtgaga 1686421 accatttacc ggactttttc atattacatt accttccttt tatcaatcgt ttccgcatgc 1686481 ataaagaaga ggctgccggc acccagcacg cctcttgata tattttattg tgatacggaa 1686541 tgtaaagcca cttctatcat atcatgaaat gtcgtttgac gctcttccgc tgtcgtttct 1686601 tctcctgtta atacgtgatc actcacggtg agaattgaca gggcttttct tccgtgcttc 1686661 gctgctaatg tatacaatgc agttgtttcc atttcaacgc caagcacacc gtattttgca 1686721 agtttttcaa tttgcgaatc gtcattgtag aactggtcag ctgtaaatac gcttcctaca 1686781 gtcaccggca cacctttatc ctttgcggca tcataggcat tttttaaaag ctcgaaatct 1686841 gcgcaaggcg caaaatcaac gcttccgaaa gcaactctgt tcatttgtga atcagttgag 1686901 gaggtcatcg ccaaaatgac gtctcgcact ttgacatctt tacgaatagc gccgcaggaa 1686961 ccgactctta ttagattttg cacatcgtag ctttgaatta attcattcac ataaattgaa 1687021 atagacggaa ctcccattcc cgtgccttgt actgagattt ttttaccttt atatgtaccc 1687081 gtaaatccat acatgcctct gacttcattg tagcattcta cattttcaag atacgtttct 1687141 gcaataaatt ttgctctgag aggatctccc ggcaaaagca cagtatccgc aatttgtcct 1687201 ttttcagcac ctatatgtac actcatctca tatcctcctg taaatctaaa ttatcatcca 1687261 gcccgtccat tttacaacga atgtcatgat gaaacaaact tcagcattga ttataaagga 1687321 atatatcgaa aaaagaaatg ttcgaggatc tgttaggcac ttcctcagaa aaacggataa 1687381 tcggggtgtt aatttgaaaa cctaaccgca ggaaggaggg gtgggacatg ggtaaaaaac 1687441 atcgtaaccg gatcaccggc caaaaaaaga acaatcatat acctgaaaaa gatatcattg 1687501 cagctgaaga agcacacggg aaagaatatt ccgctgccaa acgcaagcct taaaactgca 1687561 gaaaactgcg ggtttccgca gttttctttt cattatgtcg tttgtacaat cagacgattg 1687621 attttcctcc agccggcggg aagcagttga taatatgttt tcccttttct gccttcatca 1687681 atcaggatca cgtcccctgt ggccatgaat cttgcatcat aatcactcgg aacagtgtcg 1687741 aatacattaa acaaagagaa tgctcttttc agcacgtctt gatgatcgct cccgttcagt 1687801 tcagttcgat agacggctct gtagcccttt ttttcgccaa accggggtgt ctgaaatatt 1687861 gtcacgtcat aggaacaaga cttcttttta aacacggata acatcatcaa gatcccctcc 1687921 cttttatttc tttaacatat tggcgttttt gctgtgtttt cctctctcta tttttgtcga 1687981 aaccgcttaa tcttttcgtc aaaacctttt actaggaaaa acagaagcaa gccgaggcta 1688041 aagcctccta acacgtctgt cacaaaatga acccccagat acactctgct tatgccgact 1688101 aaaacagcaa ttacaccggc tatgatatat accatttttt tatgcttaga caaaaacggg 1688161 agatgtttca ctaaaaagta agcaataaca ggatagacac aagcagcatt catggaatgg 1688221 ccgctcggaa aactgaagga tgattcatga accagcggtg caaaatcagg cctcactctt 1688281 tcgatccatt cttttaagac tttgtttaac agccgatctg tgccgaatac taagagcatc 1688341 aacaggccgt cccatgtttt tctgtagaaa aacatgcctg ctccaatgat gacaattaga 1688401 gggagcagaa aagaagaagc accaagatgc gtgatccccg tcatgacttc attaagccat 1688461 ggctgacgga tcaaaacagc tgccttgctt attgcttcat ctgcagattg aacagcattt 1688521 gtatgaatgg ccgcagctag aattaaaaag aaaagaaaca aactaacggg cttgtacaat 1688581 tttaaccacc tcaattttca cagaagtcat agaacatgaa taataaaacc ggagctgacc 1688641 gctccggttt taagcctcac tcatcttcat ccagctcttc atctatcata catttttcta 1688701 tcaaataatc aaaggtaata tcagcgattt caaacagctc atcctcactc ggtatgtagc 1688761 cccgtcttgc aagctctctg taaaaaaatt cagcgatttc ttccgtatca atcacaagat 1688821 ctatttcttt catctccgta ccgcctcctt ttttatgttt tatgaaaaaa caggctgaat 1688881 tatacccggt gttctaaaca attctttcag tcatatattg aataaaaaac gagccatggg 1688941 aggctgacgc tatgattgct aaaatgatgg aagcactgga cggagaaaga tttgatatca 1689001 taatggaaaa aacgctcaaa ggaatgacgc gtgtgatgat ttggggctgt ctgccatatt 1689061 ttttatatgt cttgatccgt atgttcacaa attaactgaa atgctctttt aaactttcca 1689121 aaacaaacat catcatgtct ttatattctt catcctgaaa catttcgtac agaattttgt 1689181 agtcattata aatatccaga agctcatcaa caattgacac agcaaggatg tgaagggtat 1689241 cttgatcttc atcaccgcct tcaaactgaa gaagagcaga cgatgcgata tcttcgccga 1689301 tctcatggcc agtttctccg acataatgga caaacaacag ctgatgcaca aactggtcca 1689361 tttcatattt tctaagcacc agcgtgagat cctcttcctc cgtttcaagc cactctccat 1689421 cctttaaacg ggtcagctca taaatgatat cttcccagcc atcttctaaa tatctccaaa 1689481 tttctgttct atggccgata atgcgaaaga gttcttttcc ataatcttta acataaacaa 1689541 cgtccccaat aaggaattca tactcaatat caagcttctc catgtcgaca atgacaccct 1689601 cataatcttt ataaagctga atagatgatt caaagtataa aacttcgtta tgattgactt 1689661 cataaagata gtgtttatca atttggtgta cttttgtgat ggtgccgact gttccataca 1689721 taatgacgac tacgatatcc cctacttgga atttcggttt attttgcttc atggtgtctc 1689781 cccctcgccg caacatttct catacgctat cgtatgccgg gtgaagccaa ttcgcatggg 1689841 catgaaaacc aaaggaaata tccaattatg gtatgggtat ggacataaaa aaatccgcag 1689901 tgatctgcgg atgaaacagc tattatctgc cgtgcacttc agactcgtat tgatcccaag 1689961 cttcatcaaa cgtcgccatc gtgtgaaggt aatcagcatt cagctccaaa tatgaactga 1690021 tttcatgata atcggttgat gtttttggaa agctgtgatc ctcatacgcc tgattggcaa 1690081 attcactgat gctgtccttc ggcttagggt gtctgtattt caataaatag tgataaaagg 1690141 atttcatggg tttcccctcc tgatgtctgt cttttgttgt tctattatac agttcaagtg 1690201 taaaattaca acaaaagaat actgaaacat gactcaggag aagtcaaaat agttgcgttt 1690261 caaaattctt tctgtctcca tgagctgctg atatgtcagg ctttcaggca gtttttttgt 1690321 ttgaattaaa agcagctgat cctcaatctc tttaaccgtg ttttcctctt gataggtcat 1690381 accgcaggaa gaacatacca tggcaggggt gtctgtcagt tctatagccc tcgttccatc 1690441 agggagctcc cagtacaccg tgttcctgcc gggcaccgct tcgagctcgc cgcaccattc 1690501 gcatgttttc atgaagaatc ccctccgcat tcagtctctt tctgtttttt ctgctgcgcc 1690561 aaaaatttct tttctttgag ctgatctctt ttctcacgcc gatcttttaa tgtttcatgc 1690621 tccggatttg cgatgtatgc ctctctcctt ttgattctgt ctacattttc aggtgtaaac 1690681 gaaacttctt tgtcagcaaa aatggcactc agcccgatcg gctccttttt gtcagcggtt 1690741 tcagggaaaa cggactcaaa ataggcgtct gcctgattgg ggatataatt ctctggttcc 1690801 ggatatgacg taatcacacc ttcaaaattt cttaagatca ctttgtcagg actttgtgac 1690861 aggacatagt ttggctgcag ggcgatttta cctcctccgc ctggtgcgtc aacgacaaag 1690921 gtaggaaccg catagcctga ggtatgacct ctcagccctt caatgatctc caaacctttg 1690981 gaaacaggag ctctgaaatg ccctattcct tctgacagat cacattggta aatataataa 1691041 ggacggactc tgatttttac caagtcatgc atgagctttt tcataattgg aaccgaatca 1691101 ttaatacctg ctaatacgac agcctgattt ccgaccggca ctcccgcgtt caccagcttt 1691161 tcacatgcct caacggattc ttctgtcatt tcgatgcttg tgttaaaatg ggtgttcagc 1691221 cagaccggat gatatttttt caatatctcg cacagatgat cggtaatgcg ctgcggaaag 1691281 acgacgggag ctcttgttcc gattctgatg acttccagat gcggaatgct gcgcagctct 1691341 tttaaaatat attctaaaat ttggtcgttg atgagcagcc catcaccgcc tgaaattaaa 1691401 caatcgcgga tttcgggtgt ttcccggata taagcaattg cagcatcaag ctgttttttg 1691461 gggacgccca ttccgatttg tccggaaaag cgccttcttg tgcagtagcg gcagtacatg 1691521 gaacattgat tcgtgacaag aaacagcaca cggtcgggat agcggtgtgt cagaccgggt 1691581 accggtgaat cttcatcctc atgaagcggg tcttccagat cgtattttgt tttgtgcatt 1691641 tcttcagaaa gcggcacaga ctgcatgcgt accgggcatc tcggattgtc ggggtccatt 1691701 aaagaagcat agtaaggtgt aatatttaag gggatcgttt tggtagaaat tctgacgcct 1691761 tcctcttcat cctcggtcag attaatgact ttctttaaat catctaacgt tcttacagtg 1691821 tgtgtcagct gccaaagcca atcgttccat ttctcttccg gaacgtcctt ccataactcg 1691881 atctccttcc aatgccgttt cggtttatac catttgtttt tcaaacgaac tcctcctcgc 1691941 gcatattttg acttacagtt gcttgcacca aatattcatg ttttcaaggc cttcggctat 1692001 aaagcaatta ttgatcagcc ttccgccata ctgataacct gaatggtaca acacagcatt 1692061 catcccaaaa gacgaagcac gggcgagaga aaacacatga acgatatcct ctccagccat 1692121 ttctttttct aacgcctcga ttaaaaagct tgttaacgaa tggccgcgat attccggcag 1692181 cacagcgcaa tcggttattt ctgcatgccc aagctctgga ttgatttctg cgcttgctgc 1692241 gctgatcagg cggtcatgat caagcatgat ataatacacc gtatttgcat tcatcgtctt 1692301 ttcaatataa gcggggtcaa ataccggggt tgggtacgtg cggaatactt ttttatacag 1692361 catcgatagc tggtacatgt cgtttgtttc tgcttttctc atcgtaaaaa cgggtgtact 1692421 gtcgttgcga agacggggcg ctgtgcgata tatggcttcg atgatctcct gttcctctgt 1692481 ataagaatct gtttgtctcc ggctttctga aaggtaacgt accatgacac aagccgaatg 1692541 gccgagataa tagcccttta gatagccctc cggcgcaaat aattgtttgg caaggatcgg 1692601 ctcatcatgc tgcttcgcat agacaatgat tttttctgca ttctcttctt ttgccgctgc 1692661 cacgatatcc ggcagggcct tctcaatggc tccgtcataa cgaaccactc tgattcgttt 1692721 attaaagccg tcatggtcca aaactgctgt gacaccgcta ctctttattg acttgagcat 1692781 ccgcatcctc cccatctgta tgaaggccgc accaatccat gacaaaaagt gcaataattt 1692841 tagcagattc tatcatggct tcaacctcaa tgtattcatt ggcctgatga gccgtttttg 1692901 tttcccccgg cccgaaaacg atcactggtg tatctcctgc atggtacaaa agccctccat 1692961 ccgttcccca cggggaagcc tcaataatcg gctctgtctg tttcattttt tgataggctg 1693021 attgcagcac agaaattaaa gggtgatcat caggtaaatc attcggcagc cattgagcgc 1693081 caaaccattc gacttgtacg ggatggcgtt taaaccattc gtcatggtat tctaaatcct 1693141 tcagccagtt ttccaattca agttttacag cttctggttt ctcatgggga gcaattccgc 1693201 atctcccttc tatgacgaca cggtctgcaa ctgaagatgg ccaggcaccg cctgagatgg 1693261 tgccgatatt caccggtacc ggtattggga tattgtcata cagcggatct gaaattctcg 1693321 cattgcggac tttctccagc tcttgtatcg ctgtgataac gtgcatgctt ttttcaatcg 1693381 cgcttacccc ttcatagcgt gtgcccccat gtgcggataa tcccttcaca gtgatccgaa 1693441 accacatcga accctgctgc ttaataaata gtttcatatt cgtcggttca ggaatcagcg 1693501 ccccgtcagc acgatagcct ctcatgatgg cggaaagtgt accggcgccg ccgcactctt 1693561 catctacaac actctgaaac aatacatctc ccttcagttt gacatcgcag gcgtgcaggg 1693621 cttctaaagc aaaaagaagg gctgtattgc ctcccttcat atccgttgag ccgcggccgt 1693681 atattttacc gttttcttcg acagcttgat acggttcata cttccaatcc tttacgcttc 1693741 cttcaggcac aacatcgata tggccgttca aaatcaggga cctgcctccg ccggctcccg 1693801 tttttttagc cacgatattc gggctctcat gaaaatcgga tcggttagat ttaaagtagg 1693861 gatgctgttt taattgcttt atgcttggct cccatacatc aatgtccata tgaaattgcc 1693921 gcagcttttc aagcacaaca gcttgggcgt taaactctga ccccaatgtg cttttttccc 1693981 caatcagcct tttgagaaga cgaatggctt tggccgaatg ctgatcaagc cactcgatta 1694041 cttttctttc aatgtcttgc atcctcattc cccctcttaa gaaaaaggca tatctatttt 1694101 gatttcagct tctgtcagcc tcgtcacctc atcgattgtc gagccattca tcagctcttt 1694161 taaaatgaag tgatggctat cgacctcaag aaccgctttt tcggtaataa tcaaatctac 1694221 acagcctgca gcagttaatg gcagcgtaca tctttctgtt aatttaggcc ttcccttttg 1694281 atctgtatga ctcatgacga caaccacttt tttcgctttt tgggcaagct ccatcgcccc 1694341 gcccatacca ggcacctttt ttcccggaac aagccaattt gccaaatctc ctgattggct 1694401 cacctgcagg gcgcctaaaa tcgtaatgtc aattttgcct tttctgatca tcgcaaaaga 1694461 catggttgta tcaaaataag aagccccttt tacagcgcgg acaggatatc ccgcggcgtt 1694521 gcataaatgc gcatcctctt ctcccttttc gggactttct ccaatgccaa ggacaccgtt 1694581 ttccgcttga aacatgacct gcatgtcagg cttcaaaaag ttcggtacca aggaagggat 1694641 accgataccg agattcacaa tcatgccctg cttaatttca gtagcagcgc gttttgcaat 1694701 ctgttctctt tctgctactc ccaagcccat ttccacttca ctccctcgct tcgtacaacc 1694761 ccctcaacaa aaacccccgg tgtgacaatc atttcttcag aaatctcccc catcggaacg 1694821 atacgctcag cttcggcaaa ggttctcctg gcggccattg ccataagcgg gttcatattg 1694881 cgcgcggttt tgtcatacgt tagattgccg aattcatctg caatgtaagc attgatgaaa 1694941 gcaaaatcag cagtcagcgc ctcttcaatc aagtatcgtt ttcccgccac tgttacgatg 1695001 tccttttttt cgcaaaccat ttgattatca atgcccacgt cggttaaaat accgccaagc 1695061 cccgctccgc cggcgcgaat ccgttccgca agcgttccct gaggtgaaaa ttgaacctct 1695121 aacgtcccct ctgtcatctg ttttccggct actggattgg aaccgatatg cgaggcgatc 1695181 agggttttga cccgttgatt aacaataagc gggccgattc cgatatccgg gaaaccggcg 1695241 tcattgcaaa tcacagtcaa atccgttaca ccgctgtcca atatcgcttc aatcaatgaa 1695301 ggaggcgacc cgactccccc aaaaccgcca aacatcagaa ccgatccatc ccgaacatct 1695361 gcaattgctg tgtcaatgct gattgctttt tgaaatggcg ccatttaatg tcaatccttt 1695421 tttaagtttt tttcgaccgc tgcaactgtt tctgaaaaaa tagagataag ctcttccatt 1695481 tcaccgtctg aaatagtaaa aggaggagca ataatgacag catctccttc tccactgtct 1695541 attccagctt tggaaggata aacaatcagc ccgcgttttt tcgcctcgct gacaataagc 1695601 tgggttatcg cctgctctgg cggaaacact ttcttcgttt tttggtctgc cacaaattca 1695661 atgcctaata gcagtccttt tccgcgcacc tcacctataa tgccgctttg agatgccgcc 1695721 tcatcaagct tcttcttcag cacagcgccc tttttttctg attgtttgat caagccgtgc 1695781 tttaacacat atcgcaaaac ttcaagagca gctttggctg aatagggatg tgcactatat 1695841 gtgtgaccgc tcataatcac acctgaccct tgttttatgg tttcaataat agaatcagat 1695901 acgacggcag cagcaatagg tgcatacccc gcaccgagtc ccttccccag tacagcaata 1695961 tcaggtacgg tatcccaatg ctctgtcgcg agcatccttc ctgttctccc aagccccgtc 1696021 atcacttcat ctgcaataaa aagcacatcg tgtgtgcggc atacctcact taatctctca 1696081 taatatcccg gaggcggagt aatcgctgct cctgcagcac caataatagg ctcagccaca 1696141 aagccggcga tgaattggct tccgattctt ttaatcatgg tgtccagttc atcagctgca 1696201 gtctgaacaa agtcttcttc cgtctcgtga ttcagccgat aaatatgtgg agctgagata 1696261 gctggatacc gctcaatgag atgggtgaac cggtatctcc tttcataaaa accagacaat 1696321 gaaagcgctc ccaaagttat tccgtggtaa ctgctccatc gagacaaaaa gatggatttt 1696381 tgtgtttgct ttttttcctg ccaatactga atggcgattt tcatagctgt ttctatcgct 1696441 tctgatccgc tgttgacaaa aaaagaccaa ttcacatctc cgggcagctc ctgtgccaag 1696501 agagcggcta attgctcggc gggctcactc gtaaactgtg agcggtaagc aaaagacacc 1696561 tgatcaagct gttctttcag cttctcagtc acatcacgaa ctccgtggcc gatattacat 1696621 gtcaccgcac ctgacgagcc gtcgagatat ttttttccgg tctgatcata aacatatgaa 1696681 cccttcgcat aactgacaac cggataggcc gagctaagct ctggcttaat caaataactg 1696741 ctcatgctcc cacctcaaaa ccccttttac catattgtat gagtgtccaa atggcggcat 1696801 gacgttcccc gcaaaaactt tttcacataa aaagagcctt cctaataagg aaggctcttt 1696861 tgaaatttca gcatctagca aataaaagcg gctccaacaa taattaataa aatgaacaag 1696921 acaacaatta acacaaatgt atttgtcccg cagccaaatc cgtaaccgta cccagagtat 1696981 ccatacatgc tgttttcatc ctttcttatc acgatatacg acattttatg cgggccaagt 1697041 cccaaatggt ttgtgcaaac gcctatttca tgtaaggaaa taatgaaata cagtatgcac 1697101 ccgctcatat tttttaaacg tcagcttttc gtaaaactga gttgcaccgt cagtgcttgc 1697161 agccactaag taggctgctt ccattcctag tgatttggcg atggacagca tttctttcac 1697221 taagatactg ccgtagccct tcctttgaaa ctgatctaaa attgccactt cttcgatttt 1697281 agccgttttc tcttgatgat cgataaacag ctcgccgcac ccaatgggaa ctttctgtgc 1697341 ctggtcgctg taacaaacaa caagaatgat tatatctgct tcatagaaag gatattttct 1697401 ttttaatttt tgttcagcga ttgcttctcc aatataaatg gaatcgtaaa ttttcataat 1697461 agaagatccg tcgctaagac tttttgccgt cccccatgcg gttaaaggat gtcccatctg 1697521 ccccttccag tcactaagct tcatgtcata tagtagctca tcctcgacga caaaaccgct 1697581 ttttacaagt gactgcttca aaccgagcgg aaaaacatgc tgcggcgacg cttttaaatg 1697641 gagataattc gcatcaagca gctttggtac ggagggtaaa aagttaagta accgctccaa 1697701 tggaaacgta tcatggagct gaacaaagtt atgagaaaaa atttgcggaa gctgcggatc 1697761 tctgtatacg ctgtaatgat caaacgatgc cgattcagac gttaacaata tatattgatg 1697821 ttccgttttt gaataatgtc ctgtcatgaa cgtctccttt ttatgaccta tacctttact 1697881 ctgttgcaat attcaatttc tttataatct catcgtacac cggataaaac ggctttccaa 1697941 ttggaaattg ctgaatattt cggaaagaag cggagattgg cttctgatgt aaaaaaaact 1698001 tccttgttac ttgttcacta atcgggtgaa agacgccgtt tagaaacaaa aacggctcgc 1698061 gttcgatgaa aaacagacgt cggccaggcg gatttttgat caattcagat cgtttccacg 1698121 taatcggcgg cccttccgga agcgtctcca tctcttcttt tccaattgtc actatgtctt 1698181 ttctttgaaa ttgataaaat tgaaacgcat actggtccac aattcgcctt ttttttccgg 1698241 cttcgatata aaatattgca ggatggtcag cttcctttac taaaatataa ttcggaatgt 1698301 ttaaaatttt gccaatccta tattggaata aatatgggtc tggaacagcg acagtccgat 1698361 ttagatacaa aaaaccccac ttttctccaa caggatgcct tacaccctga tcaaaaaaat 1698421 acacattttg atctgaacct tttacaaaag agccgtcaat caaatcggcg ggcagaaacc 1698481 gatatgcatt ttgaaatgaa tctggggttt tataggttgt gtctaatact tcatttatcg 1698541 gcagaaatgg ggtaaagttg ttgagtctcg cccaaaaaat tgcgtcgcca tgattccaat 1698601 gcttcatatc atcatcccag tagcctccaa atttatggtg aatgagatta agtaacgaac 1698661 ggcgatgcat aactgagcaa tgatcaactt gaaaagcggc ctgatcaagc actgcattgg 1698721 catttctgta gaaatgtgag atttcctctc ccctttcgtt tacatgtaca actttttgtt 1698781 ttgaatagac cgcctgcgct tcaggcttat gtgaaaactc ttgcaccata cggctcagcc 1698841 gctcaggatg ataaacagtg tcgtcagtaa gataggaaat gtaatcgccg tctgcaaatg 1698901 ggagcgcact gttaattaat gtggcataac gggctgtttt taatcgatct gcaggatgca 1698961 cgaaactgtt atgatattga atgcgccggt catggagata cttgtgaatc accgcagttg 1699021 tttctgcatt cgaatgatca tccatgataa aaagctccca aagatcatgc gtttgctgta 1699081 tcacgctttc gatcgctttt tgcaaataat cgggtttgtt gtaacttgtt aaaataatag 1699141 acactttctc tcccatctat accgcctccc gccgtcaaac ataaaaacgg ctccgcagca 1699201 agcagagcct ctgtcatcat ttaaaaagca ccccagctta caacacttga gagtgaaaca 1699261 tgagatctcg tgttatttaa cgggttttgg aaaataacca aatcagtcag aacttctttt 1699321 acgatgacat tttgaagtgt atctccgttg atcaaattga cttttgaaac cggtacgccc 1699381 agctcttttg caaaaacaag ctggcgtctg aggtcagatg gatttccttc agaagacgat 1699441 tgacgtatca gcagaatcag caaaagcaaa ataaaatgca gatcatcttg gttttcttct 1699501 cgatccactt gtttctctaa atccaaatca tccctctccc ttatccttat ctctgtttca 1699561 caatatgtgc gacttcgatt tatggtatag gctatgtcca ctccattaaa aaatcagcat 1699621 tttccttaaa tagatgaaaa atagatcagg tacggcgttc gactcatacc aaataacagc 1699681 cggaagaata tgaataacgt gagttcacta tcgaatagga ggtgtgtgta atgagctctg 1699741 aaaatgcaca gttaaaaaag gatttaatta aagccgtttt aagcccttta tttccaactg 1699801 caacagaagg aggagaaaat atggatagta atcttaaagc cttgcttgat gctgccatcg 1699861 atcaaaaagt agatgaaagt gaaacggtta cggcagaatc tattttagac ccttctcttc 1699921 cggcaagatg gatttttgcc agaattacgc caggcactac aatcagcatt gtgactgatt 1699981 caggtgacat gatcggaccg gttgttttcg ttgctttcga tcaggttcac gggatcgtat 1700041 ttgtaacaca ggaaagctcc gtcactccgg caggccaagc tacaacatta attgatgtag 1700101 acaaagtaga aagcgttacg ttcttttcat aacatccgat gaaagtcttg tatatccagt 1700161 cgggatacgg aggaatatac agttattttg atcgctgggc tgaagaatgt tttcagaaca 1700221 ctcatacaga gtatatgatt gcagataaac ctgaagcaga atctttgatg aagatcgaag 1700281 cgtttcagcc ggatttcaca cttatgatgg ttggagaccg cgttcctcac gactggctga 1700341 cctggttaaa gggtaaggat atccccgtgt atgtttggct gaccgaagac ccattttata 1700401 tggatatcag ccttcaggta attaagcttg ctgacgccat attaacgata gaacaaaatg 1700461 cagctctcta ctatcaagag ctcggctacc agaacgtcta ttatgttccg ataccagtta 1700521 accatcggct gtttaaaaaa atgggcaccg aacattccta tcattcaaat ctgttaatca 1700581 tcggctatcc ttaccctaat cgggttcagc ttatgaaaga agcggtccat ctgccattca 1700641 cggttcgggt aatcggcaag gaatggggaa aatatctgcc taaaaaagtg ctcaaacagc 1700701 cgcatattga tgtcgtcagc acatgggttc cacccgaaca ggccgttcat tattataatg 1700761 gggcagacat cgtaattaat gcgcatcgtc cctatcattt tgctttcaac caaaatacta 1700821 tgcgcatcaa aaatgccagt tttaataacc gaacgtttga tatcgctgca tgcgaagcat 1700881 ttcaattaac agatttaccc gcggcgcatc ctttttcatc cattatttct tatcacggca 1700941 tgaacgactt taaggaaaaa gccgctttct atatcaacca ccctgaagaa cggcaaaaag 1701001 ctgcagcagc caattataaa gagaccgtac ccgcatttac gtttgatgag cttcctgcaa 1701061 aactaaaagc gattcatctg gcgctttctt gaaaaatcgt tcattgctat gaacgatttt 1701121 tttattcata gaaaaaagca gctgcacaag ctgctttcta ttctagccgt cagaacggtc 1701181 tttcagcttc ctcggattta cctgtttatg aagatcaggc atttcgccga gatgctgtgc 1701241 aatttgttcc cacgatacaa ttttgaaatt ttgattgacg gcttgtccgt tatcaatatt 1701301 ttcgccgtcc tgcgccacaa aaatcccgta cggatatttt gggccaagtc cgaaaccgag 1701361 aacatcaata ccatccgtgt cactagtacc gtctatcttc tcgccatctg taatctcaaa 1701421 gttggctaca tagcgatttt tcccctgccg ttcatacatt gcatagctgt tatttccttg 1701481 acttgaagcc atgagatatc ctttgccatt tggtgcataa tagattgtca gtccttcaat 1701541 atcagctgtc aaatgatctc ctgtcgcacg gtcaacaacc tgcccctttg accctccgcc 1701601 gggctcagcg ttaaatttcc agatggcctc atcttcctct gctatgtata ggtttccgta 1701661 ctcatcatcc gcaacaaggc cttcggtctg agaattcaac ttaaattcac gcaccttttt 1701721 ccctgttaca taaccctttc caccatcaac aatttcatac tgctcaaatt ccccttgttt 1701781 gcctgtcact aatgcgtaaa atgctcctgt tttctggctg tgatacaagc tgaatccata 1701841 aacctcagaa atattggtgg aaataggatg gttcggatct gtaatgcttt tcaattttcc 1701901 tttatccccg tctattgcat atacttcaat tgtatttttt ccttcggacc ggttggatgc 1701961 ggcagcaata tcaatttttt cgccgttcaa tggaaaatca tagcgcagat cgacattatt 1702021 gagcttgcca aactcataag aatgaagctg ttttccgtct aaatcataca caacgagccc 1702081 tgacttctta tttgttgtaa tcaacttgct tttttccggg tgtttttcat gaacccaaat 1702141 ggccgggtca tctgctgcat catcgccaga tgcgaccgga tctgtctccg tgtgtgcagt 1702201 cactttgaaa tgatgttcct cattcacata atgagccgac accgaggttg ctgtcaggct 1702261 aagcaataaa cccgcggcag tgcttagcag cattgttttt ggaaccttca tttggtaccc 1702321 tcctctttta tcactaacac tactattgta aaatatatac aggtgattac cgtgaggaaa 1702381 atgaaccttt ttttataggg tttctgactc ataaacaact tattccccaa agaggtggtg 1702441 agatgacttt gccagattta cttttgcgga gcgaaataaa aatatgttga atatttagta 1702501 cattatttat ttagttttgt ttttccctag ttacgtccgt ttttccattt tctattaaaa 1702561 aagaacactt tgtgacatga tcattcccct aaattttgtt ttattggttg ctttcattaa 1702621 ttcgattaca aagttgaaca tatgatgcat ggtagagaaa cgagagttgg aggataagcc 1702681 atgcctaaac agcaaacagc agaactaaaa ccatttttcc ataacaaaac agttttagtc 1702741 actggcggaa cgggttcaat cgggagtcaa attgtcaaac gccttttgat gcttacacct 1702801 aaacaggtga ttgtattcag caaagacgac agtaaacagt atgtcatgag ccaaaagtat 1702861 gcggaggata agcggctatt atttgtactt ggagatgtac gcgatcacag aagggtgaat 1702921 caggtgatga aaggcgtcga tatcgtcttt cacgcggctg cgctgaaaca ggttccgaca 1702981 tgtgaggacc atccatttga agcgatccag accaatctca tcggcggaca aaatgtggtg 1703041 gaagctgccc tttcacaccg agtgcagcat gtcattaata tcagtacaga taaagctgta 1703101 tctcctgtga acacaatggg tgccaccaag ctgttatctg aaaagctgtt tcatcaagca 1703161 aaccgccacg tccaaaacaa aggaaccttg ttttgttcgg tccgctttgg aaatgttctc 1703221 ggttccagag gttcggtcat ccccatatta tttgaacaga tgatggaggg tgaacctctg 1703281 accatcacag acaaaaacat gaccagattt ttcatgtcaa tagacgatgc agctacattg 1703341 acattacaat cggctgctat tacaaaaggc ggagaaacct ttattttcaa aatggaatca 1703401 ctgaaacttg aagaactgat tcatgggttt gaagaatatg catcgcagca cgggctcccg 1703461 cggccggctg cagtagaagt gggcaagcgt ccaggtgaaa agcttcacga agaattaaca 1703521 tctccacatg aaattgaatc actgtatgaa tggggcaacc tttatgcgat ccttccagag 1703581 ccggaaaaac atcctgactt tcgcaaagtc aatctgcctg ggtatcaatc agatcaagcc 1703641 ccgctcatta cgaaagaaag aattgctcag attattgaag aattgcatca agagaaaaag 1703701 gcataaaaac aagcctgtct atccattagg caggcctgtt tttaacagtt tatttattaa 1703761 agagatgcag atagctttcg tatccttctt cttttagctt atgcttcgga acaaaccgca 1703821 gcgctgctga atttatgcag taacgaagtc cgtttggccc cggtccgtca ttaaatacgt 1703881 ggccaagatg agaatcagca gttcggcttc ttacttctgt gcgaatcatg ccgtggctcg 1703941 tgtccagttt ttcttccact tcttcttcaa tcggctttgt aaagcttggc cagccgcatt 1704001 gggaatcaaa tttatctttg gatgtaaaca atggcttgcc tgacacaatg tctacataca 1704061 acccttcttc cttatgatcc caatattcat tttgaaatgg cggctccgtg ccgttatttt 1704121 gcgttacttc atattgcatg cgatttaatg actttatttt ttcttcttta ttgtacgcca 1704181 tttatttagc cccccaatgc tcgctgataa atcccgctcg tccggaacct gtccggtagc 1704241 gctgataatg tgctggattc tttttataaa aatgctgatg gtagccttcc gcttcataga 1704301 aaggttcagc ttttaaaatg tccgttacaa tcggatcttt aaagatgccg ctttccgcca 1704361 gacgttgctt ggaagcttcc gcaagctcct tttgtttatc attatgataa aaaatggctg 1704421 cgcgatagga actgccgcga tcagcaaatt gccctccggc atctgtcgga tcgatttgct 1704481 gccaaaataa ttcaagcagt ttttcataag ggaatacatc aggatgaaac gtgatttgaa 1704541 cggcttcacg atgtcccgtc gtttcactgc acacctcttc gtacgtaggg ttttcagtat 1704601 ggccgcctgt atacccggac accacttttt caattcccgg ctgttcgtca aaaggtttaa 1704661 ccatacacca aaaacagcct cctgcaaatg tggcgatttc ttttttttca gacatactgg 1704721 tgcctccttt gttaatacgt ggtattatta tattatagca tgtaaaaata gaatgaaaat 1704781 gattctgctt ttcaataaaa tctataggtt ttaagcaata tgcttatgta atggaggttc 1704841 acaaatttga aagtaagaac acagatgatg tacgatatgg aaactttact ccgtaaagtc 1704901 tttaaacaaa tacgcaatga aatcaatgaa attttagata aagagctgtc gcggaatgaa 1704961 ttcaccattc ttcgaatcct tagtgaacaa gggcctaaaa aagtcactga atttgcgcct 1705021 attttagagg tatcggcaag ccacattacg gctgtgaccg atgcgctggt agaaaaggaa 1705081 tggattacga gaatcagatc gaaggaagac agacgcatca tccgcattca tatcactgaa 1705141 gcgggcgaaa aagtccttca gcactttaac gagaaaaaaa cggaatattt ctttaaacgc 1705201 tttgactgct acactgatgc tgaacttgcc acgttaatcg agctcttcag caaacttgat 1705261 aaaaaacggt gaaaaaaagc acataccgat atataggtat gtgcttttcg cagtgcttca 1705321 cttatttttc agtaaacagc ttcattgctt tccagcggcc atatctataa tacaaaaatg 1705381 ccgcgcagct gctaaataaa aaactcattc cgattccaag cccgattcct ttttgtccaa 1705441 gccaagctga aaatagagct gtgaaaggat acctcaacac ccaaaacgag atcaaattta 1705501 ataccagaac ctgcagcatc gctcccgcgg ccctgacgat tccgttcagc acaaaattaa 1705561 ccccaataaa agggtagaaa aacgcgatcc acttcaaata ttgttcacca aatgcgaccg 1705621 catcaggctc actgataaat aaccttatga ggtatttacc aaatacccaa atcataaccg 1705681 caatcaccag catgcaggaa ataacagcta tcacacctag ccttgcaatt gttcccactc 1705741 ttttttcgtt tccgattcca atattttgcc ctgccatact attgacggcc gtaccggcag 1705801 ccattgctgg aagcgtgatg atgctatcaa gccgctgcac cgcgccaaag cctgatacca 1705861 cgtgatcccc gtatgagtta acaacactca taatcgccat cataccgcct gtaatcacca 1705921 tcatctgcag acctgccgga atcccgagtt tcaaaatcag cgcggactct tcccacttgg 1705981 gcattctcgg aatcgagaat ggcacaagct tgtgtttgat gacataaaac aacccataca 1706041 aaaacgcaat gccctgtgac aaaatcgttg aataagccgc tcccgctatt cccatgcgga 1706101 acacagaaat aaagagcggc gcaagcactg tattcagtac aacagcaaac gcaataaacc 1706161 ggagaggtgt cttgctgtcg cccagcgcac gaagcacagt actgataaag ttataaccaa 1706221 acaaaaataa aatgccgata aattgaatct gtaaatacgt ctcagcaagc ggtatcattg 1706281 actccggcgt ttttagaaga cgcagcaaaa gctctgagag aaaaaaaccg gccgcgccga 1706341 atccgatgct taggcctgtt aataaaacaa caaaagcgtt aatatacgac gccattcctt 1706401 ttatatcatc ttttcctttt tgctgagata aaatggttaa cgtcgcattg ttaaggccca 1706461 aaataaaaga cagcacggtc aaaacaatcg tgcttgatac cgcggctgcc ccaagggcct 1706521 ttgcccccag taaattgccg atccacaagc tgtctataaa ttgaaaggaa acctgcaatg 1706581 cgtttccgag cataataggc attgaaaaca gtacaagctg tttcagcacg ttcccctgtg 1706641 taaaatcgta tgctttcatc ttttctcctt gtgttctcaa attttcttcg gaccacacga 1706701 aaaaagagac gttgtttcat gtctcttttt tcatgactta tcggtttttt ttcggtctcg 1706761 cataccgaat gtaaacacca tcacacttag gaacaaggca caataggaaa cattcaaata 1706821 catttgatcc atatcttcag cagccagatg atgataagca agccagccga agtacaggga 1706881 aaatgtaaag gataataaac tgaaatactg gtaaatccgt ttcattttca gtcacctcta 1706941 ttgtttagga tggtaatagg aaaactcaat ttcatctttt tctaaattta tcttatccgc 1707001 tttgacatac attccattcg ttaaaggcat ttctgacaaa cgcacttcaa tgcttttatc 1707061 tccggggtga acatggacaa atgacggcaa ttcataaaag ctgtccatat aatttaacac 1707121 aaagctaatt ggtatactca atttccctaa cgaaaatttc gtgacattca gctctacatc 1707181 accgtttttt ttcacggtcg gctcaaaagc gataaacgca tcaatagacg tggaaaatgc 1707241 cttgattttc cctgcgacat gaacatcatc atcaatctct actttataat caagcttgtt 1707301 tgatgctttg tcgtttaaat atgagttaac aaacgcagct aatgattctt ttgtgcttgt 1707361 cacttgaaat ccatactcgc tctcagatgc atctttcacc tgagcctgtt cccccggaag 1707421 caaaacaagt gccacaaacc cggcggcgag gataaaattg attgcaagca atataaaaaa 1707481 cagtcgcttc cacttattca tgctgtcacc ctactctttc ggtaatcctt cttttttaat 1707541 ggcttgatag acgcgctttg cgataagaga ataacccgta ccattaggat gaaaatcatc 1707601 ttcctcagaa attcggctgc tgtcactttt ttgattaaac aaatcttcga tatggacgat 1707661 ttttgcatgt ttatcttttt tcagctcttt ttcagcaata tggttccaat ccgtgacgac 1707721 accatttatt tcatttagtt ctgataatgt aaacgtaaac ggattgtaca tgctgacata 1707781 aatcagctca gcgtgatcat tcagctcgcg aatttcagaa atgatttttt caaagcgctt 1707841 ttcgtacggt ttttccgctt cctgaaacgg ttcaacggtt aattgcagaa agttttggcg 1707901 aaggattttc atcaaatcat taccgccaat tgtaaaaaag acataatctg cgtcctttat 1707961 gcctttttga acctttttat cttttagttt ttctaataaa tcatccgaac ggttcccttt 1708021 tacagcataa tttttcacgt cgaccgtttt gacttgttta tctgaccgga tagaatccgc 1708081 caccttgccg acatatccct ttccgtcggg atctccgact ccttctgtca gcgaatctcc 1708141 gacagccgct atgacaatgt gttcttttgt tttcgtttca tgggcttttt gttttccctc 1708201 agatgatgta cgtatgctcg tacacgcagt aagaagcaaa atcaaactgg ccatgattga 1708261 aaaaatgcgc agcttcaatc ttgttgctcc ttcccattct actagtggaa agtgtatcat 1708321 gttttagaag atttgcaaat gcctagtctc ttagcttact tgagtgtact ggctgacttc 1708381 acatcggaaa tgatatcatc gtacggtgta ttctccactc cattgtaatc tttcagcacc 1708441 ttaccgtccg gacctaccaa ataaaaagaa gattgatgaa tcacttggtc ctctccctcc 1708501 ggcttcttta cgatcgcttt aaagctctta agtgcgaact cctcaatctc actctggctg 1708561 tatcccgtga gaaaatccca gttatcaaaa gataatggat aatttgcggc aaatttcttc 1708621 agctgtttcg gcttatcgtt ttctggatca acactaaatg atatgatgcg gacatctata 1708681 ttttcggctt tcagtttttt ttgcagatcg gtcatatgag cggtcattgg cggacatata 1708741 gtttcacaat tggtaaaaat aaaatccgcc agccatactt ctccttttaa actctctaaa 1708801 gaaacgttct tgccgtcttg gttttgaaat gtaaaaggct ccacctcgta attgagcgga 1708861 tctttaatct gctgtcctcc gcatgcacac aaaaacagaa aaatcagccc agccgttaac 1708921 cccttgataa ccttcatgac atccatcctt tccagccagc ataaaaacgc tttctaaaac 1708981 cgtccttact gtcccatgtt tgtattcgat actgagcaaa aaaaatcctg catgcctccc 1709041 cattaacgat tacaaaggag ggcatgcagg taaaaaacgg catgttacgc gttgtgcttt 1709101 aacacctctt gatgaaatac agcctgataa tctgcccact tcatccgccg cttcatataa 1709161 tgtcggaaag aatacacttt tgccctgctg tttgatgaaa acacttcttt taagtagaat 1709221 tgcaaatggt gatgtaacat aaagaaatag tgctcatctt cctttaatac aggtatttct 1709281 gtcactttca cctgaatccc gtcaccgcgt ttgaactcta ggcttttgag taacaagcta 1709341 tcaatcctct tttttgtttt tcttctatta tatatgatgc cagccgggct gtctgtcatt 1709401 ttgcgcggtt gtgtaaaaaa attagattag caaatggaac aagtcctcat ccttgttcac 1709461 ctctacataa tgaaacggtt ttttgttcat ccgttcaatc agcggcccat aatcggcttt 1709521 gttctgcagc tcgatgccga caagagcagg tccattgctt ttattatttt tcttcgtata 1709581 ttcaaacctt gtaatgtcat cattcggccc gaggacttcg tcaagaaatt cgcggagcgc 1709641 ccccgctctt tgtggaaaat tgacgataaa ataatgctga aggccttcaa aaatcaagga 1709701 acgctccttc atttcctgca ttcttccgat atcgttattg cccccgctta ccacacacac 1709761 cacgtttttc cctttaattt gatccttgta caaatcaagc gctgcgacag aaagagctcc 1709821 agccggttca gcaacaaccg cacattcgtt atataattca agaatggatg tacatacttt 1709881 tccttcaggc acaaggagaa tgtcatcaac gacagtttcc agcgtccgga aggtttcctc 1709941 gccaattttt ttaacagccg ccccatctac aaacttatca attttatcaa gtgtgacgac 1710001 atgcccagct ttgtttgatt caaagtagga tgccgctccc gccggctcaa cagcaattac 1710061 ctttgtatca ggagacacgt ttttcaaata tgtacctacc ccagagagaa ggccgccgcc 1710121 tccgacactt gcaaaaagaa aatgcggttc tgtatcaatg tcgtttaaaa tctcgactgc 1710181 gagcgttccc tgtccggcca tcacatccgg atcatcgaac ggatggataa acgtccgaga 1710241 ttccgcctca cagcattcag cagcgctttt atacgcgtcg tcaaacgtat cgcctgtcaa 1710301 aataatatcg ataaatcctt ttccgaatag ttcaacttga gatacttttt gtctcggtgt 1710361 agtagacggc ataaaaattt tcccgtgaat gccaagatgt ttacacgaaa atgccacacc 1710421 ttgagcgtgg tttccggcac ttgcacacac aactccgttc tctgtctgct cgctggaaag 1710481 ctgtttcatt ttatgataag cccctctgag cttaaaagat ctgacaactt gcaagtcttc 1710541 gcgttttaaa tagatattgc attcatatct ctcagaaagt ctgtcattcc tctgcaaagg 1710601 tgtgtgaatg acaacgtcct ttacgttttg gtgagccttc aaaatgtctt tcacttggat 1710661 gagagagttt tctttaagca acggtttcat gtacagattc ctttcttgtt ttaaatccct 1710721 atttaatatg ccattataac atgaatattc aaaaaataag acaattattt ttatttaata 1710781 attaaaaaaa tacagactat gtccaccaca tcttgtggta acttctgttc aaccattatc 1710841 ctgcagagcc aagaaaaaag atgatcgtaa aataaagggt gttttcaacc aaaaggcatg 1710901 atataatgaa accaattaga accaaaagga gccaattgat gaatagtgca ccaaaactca 1710961 atacatttca acatctaatc ggagaacatc aaacttttct ggaagcgaag cgaatcgcca 1711021 agcagttctc gttatcggag cttcctgtct taataacagg aaaaatcgga acaggcaaaa 1711081 atcacttcgc acatgccata cacttggaat cttcgagaag caatgaaccg tttataagcg 1711141 tcaattgcag cacccattcg gaagaaaccc ttattcatga gctttttggc cctaacggaa 1711201 acacaggtgt ttttcaaaaa gcggtacgag gaaccctttt tcttgatgat gtatggcgca 1711261 tgcctgcttc tgtacaagct cagctgttaa aagcgcttga ttcagacacg gagaaaccgc 1711321 gaatgatctg tgcttctgca gaccgatccg tggaacatac attcaggcaa gacttattct 1711381 acagactgaa cattttaacg ctcacactgc ccgaattatc ggaacgaaaa agcgatattc 1711441 cgcttttgac acagcatttt ctctcaaatt ctggtcagca attgttaatc gatccctccg 1711501 tttttcccgt gcttgagaag catgcatttg aaggcaatgt cagggaatta aaaaacgctg 1711561 cagattatat ggcggcagta tcaagcgggg gaacgattca gccatatgac ctgccgccgt 1711621 atattagagg cacgatagac ggaaaaacgt cgaagaaaaa agcgaaactg cttactttaa 1711681 tggaaaaagc tgagtttttg tttattttgg aaacaataaa agtattgaac gaaaaaggag 1711741 aacctgccag cagacggatc atttctgaac acagcaaaaa tacccaaacc tcgttaactc 1711801 ctcagcaggt cagaagccgt ctcgactatt tggagaaaaa agattatgtc accaaaagcc 1711861 gcggacgcgc aggcacaaaa attacctttg agggcttgag ctttatagag acgttaaaaa 1711921 atcaaatgat ctagcgatcg aaaggagaat gtacttgttt acaatcaaag aagagatcgc 1711981 caatgcgatt acacacggca tcggtgtcct cttatccatc ccagcattag tgtttctaat 1712041 catatttgcg gctaattacg ggtctgcatg ggacattgtc agctttacaa tattcggtgt 1712101 ctctatgctg ctgttatatt tgagctccac cctgcttcac agcatcacac ataaaaaaac 1712161 gaaggacatt ttggagatta ttgatcatag cgcaatttac gtactcatcg ccggaaccta 1712221 cacgcctttt ttgcttgggc cgctgaaagg cacactcggc tttaccctgt tggttatcgt 1712281 atggtcactt gccctaggcg gaatcgtttt taaaattttc tttgtgaaac ggtttatcct 1712341 attgtcaacc ttcgtgtatt tagtcatggg gtggctgatg attattgcag ttaaaccttt 1712401 atatgcttca ctgagcggag cgggattcag cctccttttt ctcggcggca ttttatactc 1712461 tgtcggaacc atcttttaca tttggaaaaa gatccccttc catcacgcca tttggcacag 1712521 ctttgtattg ggcgggagcg ctgccatgtt tttctgcgtg ctcttctatt gtgtaaaggt 1712581 gcctttcctt tcgtaacagt aacagaaaag cgcagtcttc acgactgcgc ttttttatgc 1712641 acgtaattgt ttttcattgg caggtatata agcttttgaa aaggacaatt caatgtctgc 1712701 cggttttaag cgtttaaaaa acgagccatt ttgcatgtta tctgttcctt tcgtttccac 1712761 catcaccaac ggaagatgat agcgggccgc aagttctaca ggatcaatag aaccatctag 1712821 tgaaagaatc aggctttgtc ccttttccag ctgttttgtc acatcttcat ataccttttc 1712881 tgaatccccg tctgaaatca catccatccg atccagccat tgcccgataa aaggcaagcg 1712941 gaacactttt gggttagcga taaagccggc cggttcctca atatatccag caattaaggc 1713001 cagttcagcc aaacgcaaac ggggatgcac atacaaaaca ggaccgtgtg gtattggctc 1713061 tggctgatgg atcgtcacaa ctgaaccgga gatgccgata cagccttcta aaaacgcctt 1713121 tggctgttcg tacacaagag ccatctgttt tttgtatgac agacggggat cgagcattgt 1713181 ttgattaaat aattgtttca tattttttaa cagcatatac acaatataaa ccactagaag 1713241 gctgtagcga accaattaaa atcctcccgc tttagaagaa ttcttttttt catacattag 1713301 aaattcgtaa tcatacgggt ttttttcgtc tttggtcccc tgctcagaag aaaccagctt 1713361 ccaattggat tcatcaaatt caggaaagtg acggtcaccc tcaaactcgt gatgaatttt 1713421 cgtcatatac agtctgtccg cataagggaa caggtccgta tagagctgag cccctccgat 1713481 cacaaagcat tcttcagggc ctgaacaaat gtccagtaca tcctttaatg aactgacaac 1713541 cgtgcatccc tgaaattctg aatccggcgc tgaggtaacg acaatatttt tccgatttgg 1713601 aagcggacgt ccgatcgatt caaatgtttt ccggcccata atgattgaat ggcccgatgt 1713661 tattttctta aagtatgcaa gatcattggg caaatgccac ggcaaatcat tgtctttgcc 1713721 gataagcctg ttggcatcca tcgcaaaaat gaatgaaatc atacgctgac cgcccctttt 1713781 atatgaggat gcggatcata atcctcgatg ataaagtcct caaatgcaaa gttaaaaata 1713841 gaatcaacct ttctggcgaa acgaagctgc ggaagcggtc taacatctct ttccagctgc 1713901 aaattgactt gttcaatatg attttggtaa atatgaacat caccaaacgt atggatgaac 1713961 tcgcccggtt caagcccagt cacatgagca atgatcatgg ttaggagggc ataagatgca 1714021 atattaaacg gcacacctaa gaaaacatcg gcagagcgct gatacagctg acaggacagc 1714081 ttgccgtcag acacatagaa ttggaacagg caatggcacg gcggcaacgc cattttatca 1714141 atttcaccaa cattccaggc gctgacgatt aagcgtctgg agttcggatt tgttttaata 1714201 tcttcaataa gacgggaaat ttgatcaatg gtttctccat cagctccccg ccaagaacgc 1714261 cattgggagc catatacagg tccaagttca ccgttttcat cagcccactc attccagatt 1714321 cgcactccgt tttcctgcag atagcgtaca ttcgtatctc cttttaagaa ccacagcagt 1714381 tcatgcgcaa ttgatttaaa gtggagtttt ttagtggtga gcatcggaaa gccttcccgt 1714441 aaattaaatc tcatttgata tccgaaagtg ctgattgttc cggtcccagt ccggtctccc 1714501 tttttctcac catgctctaa aacatgtctg cagaaatcct tatactgttt catttttttc 1714561 atcctttaaa agtagtcttc tagtagtgta acacaataaa aaatcatttc tgaacccaga 1714621 aatgattttt ttatagtcag ctgacgacag gcttttcatc ctgttctttt tcttcatctt 1714681 gcagatcctg atgcgtatgt gcaattctgc tcgccgctgc tgcagcaaga gctgccacaa 1714741 tatcatccaa aaaggtgtga ataccgtctg gactttcatc aagttcctta ataattccaa 1714801 tcttctcttt atccaaataa ccgaaattgg tcaaaccgat cgacccgtac acattaacga 1714861 ttgaaagcgg gataatttca tctatgccgt aaagcggttc atccgtttca acaaggtgct 1714921 gcagcggttc ggggagaagt ttctgttctg caagctgatc gagtgcaagg cctgtcaaaa 1714981 cagcatgaat aatttcacgt ttgttcagga ctttttctac attctccatg caaacactga 1715041 gcggcagatt tggattgtat ttttcctgaa gtttttgaac aatccgtgca atatcttcta 1715101 tcataacgcc ccgtttgttc agcatatcct ttgttatatc gaccatttca ttcattgtgt 1715161 actttttcat gtctaatggc atctccttta ggcactcatc cagttgggag gcgtgttgcg 1715221 gtcccagtaa atgctcccaa gctcatgatg tgattgaaat ccatcttctg ctgtatgata 1715281 atgaaaatta aaccagtagc cgtcatgagg cgggtggtct cttcgcacat ggaatctgag 1715341 aagatcttct ccagttgtcc gattgtaaac gttgaaaatt ttttccgttt tgcccgctga 1715401 aggcatgctt gagatcacaa catcttggta cgcctcatca tcttgcaatg tcgctaaata 1715461 atcactaatc acattttcga tttttggcag gatctctttc cgatagtcat cctcaatgac 1715521 aggagcgatt ctgctgccga attttaaaaa ggactgatcc tcagcgctgt caaggagctg 1715581 ttccttgtac gattgaaaaa gcagttcagg atctcgcctg tcatccgact catcatcgta 1715641 caggtcatgc tcatcataaa aagcggtgta atcattctgc tcaagactgc tcggctgtcc 1715701 ggaaggcttg tccgccataa gggcagccgg aggagatacg agcccgaacg ttacaatggt 1715761 aaataaaacc acaagggtct ttctcatcca caatttcatg actgcttatt cctctctatt 1715821 ttattgtcat gtttctctta ttttagcaca tccaaaacat gcaagtcatg tactatatga 1715881 aactgatatg caaattagga gattcgttgc tatgcacttt gtgtaaaaac gcttacaata 1715941 tttcatgaaa ggaggctttc cgcatgattg acgctctgtt tgccacagtt tcactcttaa 1716001 cattattata ctttgtcgtc atggaggtca ccgattaaca gaaagcccgt gatatgaatc 1716061 acgggcttgt ttgaatgacg ccataatgga acagtgctgt ttttcttttc atgacgttaa 1716121 aaccaaactg ttcaaaccgc gggcttttcc agtggtcttt tagcacaacg ctttttctgg 1716181 cgactcgtac cgcttcattg atacatcctt cgtgcaaaac ggaatcctct gccaaatcac 1716241 gtaaaggcgc gatgccgtca gaggtttcta caggttcatg aaacattgga tcgaaataaa 1716301 ccacatcaac agagttgtca gggagctgct tgatgtgttc aaagcaatca ccattcttca 1716361 cctggattct tctcatcgca gcttgaagct cttctatacc cgtttcccat gaatgcagcc 1716421 ccgtcctcac taaaacagac acaagatggt ttttttcaat cccaacaaca gaacccgttt 1716481 cgcctactgc catacttgcg ataatggcat ctgaccccaa cccgagtgtg caatctaaaa 1716541 acgtatcccc ttcagataag ccggcagccc gaagcatagg ttctttctcc ccctgtaaga 1716601 agcgtttggc tctgaacatc gctgtattcg gatgaaaaaa gaatttggca ccttgtttcg 1716661 tatacagctc aaaccgctct ttgccgacca caagcaaatc acgttcagct gatttcagca 1716721 ggtgctcaac cgtttgttta ttccggccgc agtatggcat atttagctct ttagaaagct 1716781 gctttgcagt ttttatggtg tgttcagacg gtctatagct tgttgttatc atcttctgta 1716841 ctcccaaaaa gaaaatgccc ggagaacggg catttagcag tgcgcatcga aggcagcagt 1716901 cagatttttc atgatttctt ccatatcgtg tccttcaatt tcatgacgcg gaataaaatg 1716961 tacgacttct ttgcctttca aaagagccat tgatggtgaa gaaggctcct ggccagtaaa 1717021 atactcacgc attttcgcag tagcttcttt atcttggccc gcaaatacag tcaccgtatt 1717081 gtcaggtgtt ttgtcattct ggaggactgc ctgtgtagcc gcaggacgcg caaggcctgc 1717141 cgcgcagccg catacagagt taacgactac aagagttgtg ccctctgcct tttccataaa 1717201 gttttctact tcttccgctg ttgttaactc ttcaaaacct gctccagtca gctcgcggcg 1717261 catcggtacg acaagctggc gcatgtattc ttcataagcc attgacataa aaaaagcccc 1717321 ctctagtatc cttcatctga agtaaaggat actatagaga gggccggatt tcaaatgttc 1717381 acgccttaaa ataaaagaaa gtgtccccag ctatctagat tttcataata ccgccggtgt 1717441 tggcacttgt cacaagttta gaataacgtg ccaggtagcc ggttttcact ttcggttcaa 1717501 aacctttcca gttcgctttt cgtttttccc actcttcttc tggcacttgt acatccaaga 1717561 tgcgtttttc aatatcaacg ataatatggt ctccgttttc aacaaaggca agcggcccgc 1717621 cctcagcggc ctcaggtgat acgtggccga ttgagaggcc acgggaggct ccggaaaaac 1717681 gtccgtccgt aatcaatgcc acttttggcc cgagtcccat tccaacgatt tgggatgttg 1717741 gcgccagcat ttccggcatg ccaggtccgc cttttggccc ttcgtatctg atgatgacaa 1717801 cgtcgccttc ttttactttt cggttgataa tgccgtcaag cgcctcgtcc tgagaatcga 1717861 atacgacagc cggcccttcg tgtcttgtaa tcccattctg tacgccgcct gttttaatga 1717921 tagcgccgtc cggagctaga ttaccgaata aaacagcaag gcctcccttt tcagtgaatg 1717981 gttgatccag cgggtgaatg acgtcataat cctttacttc atgtccggca atggtttctc 1718041 caagagtttt tcctgtaaca gtcagcgcat ctaaatgaag cgctccttct ttcttcgaaa 1718101 gctcattcag agccgctgaa acgccgcccg cttcgtgaag atcttcaata aacacatccg 1718161 atgcaggcgc cagcttagcc aagtgcggca cgcgctcagc gacttcgtta atgcgttcta 1718221 aagagtattc aacgccggct tcgtttgcaa gggcaagggt atgaagaacg gtatttgtag 1718281 aacctccgag cgccatatcg agtgcaaacg cgttatcaat cgcttttact gtaacaatat 1718341 cacgcggttt gatatctttg cgaatcgttt ccattaattg cgcagccgat tttctcacaa 1718401 actctttgcg ttccggagat gttgccagaa tggttccatt acccggcaaa gcaagaccaa 1718461 gtgcttctga cagacagttc attgagttcg ccgtaaacat gcctgagcaa gacccgcacg 1718521 ttgggcatcc gaactgctct agttcttgaa gctcgttttc gttgattttc cctgcttggt 1718581 aggcgcctac cccttcgaat actgaggaaa gggagatttt tcgcccgtca cttgttcttc 1718641 ctgccgccat cggtccgccg ctgacaaaaa tcgtcggaat gttgatgcgc attgccgcca 1718701 taagcattcc cggtgtgatt ttgtcgcagt tcggaataca gaccattccg tcaaaccagt 1718761 gtgcggatac aaccgtttcc acagagtctg cgataatttc acggcttggc agcgaatatc 1718821 tcataccgat atgccccatt gcgatgccat catctacccc aatggtatta aattcaaacg 1718881 gaacgccccc tgcttctctg attgcttctt ttacgatttt cccaaactcc tgcaagtgaa 1718941 catgaccggg aacgatatca atgtatgaat tacacaccgc aataaacggc ttgccgaaat 1719001 cctcttcttt tacccctgct gcacgaagca aactgcggtg cggagctcta tcgattcctt 1719061 gtgtgatcat attactgcgt aattctgcca tggtgatcct cctaaattct ttcaattgtt 1719121 tgattggatt ttattttgac aattttcagt ttatttatgg gctgtttttg caaataagat 1719181 aaatacaggc cgccctcacc ttgttttgtt ctttcgtgtt tttatattta tatagctttc 1719241 tttcgatttg aaccctccaa ctattaatat tgttacttac tataaatagt tttcggatat 1719301 ttttcaacaa tattcgaaat aatttttata aaaagtgaat tcacataaaa aaggtgcatg 1719361 atctgcacct tttttatctt tattcgcctt tttttctgct ttccgtcatt tgtttccaaa 1719421 cagaaccttt tgcttcttct ccatgctcaa tacgttcaag cgccattttg acttgaaggc 1719481 tgacctcaaa ttcggggtca tcttcggcag cgcgcaaagc ttcaattgca ctttcatcgc 1719541 cgacttcgta caggaacatg gcggcacgcc agcgaacaag cttgctggag tcgcttaatg 1719601 acttgatcat agcaggaatg gcttgaggat cgccgatatc agacaggcag tctccggccg 1719661 ttcttctgac tgatacagct ttgtcctcaa gtgctttata caatagagga agaacatcag 1719721 gtgtttcaat cattcctaag tacacaacag cctgtcttct gatggacacc tttggatcat 1719781 ccaatgcctt ctgtaaaacc gggatatcct cttctttcgg atccatctgt tccaagtgtg 1719841 cataacgctt tttccagtcc tcatcatcca gcatatcaag cgttacttta tacgctttgc 1719901 gctgtacagc ttgttttgct tcgccctttc cttgagcggc tgcttcagtc agtcgtttca 1719961 gccgttcatc actgtatgcc gcttgaagct cttctgtcac atcatggccg atttcatcaa 1720021 agtcaccgaa tctgacacct tgttctttcc aagcccgctc aaacacaaca ttggaagctt 1720081 cagatctaag ttttaagatc gcctgctgaa agcgttcagg taagccgaag cgttcttccc 1720141 gctctccatc ggttaattta acttgcatag gaatgccgct gaacatctgc acaaaaactt 1720201 ttacctctcc aaaagattct tgatcagaac gattttcttc tgcgctttca gcactttcca 1720261 tcccaaatgc agtgcggact tgcggtaaaa tgtctttcca gtcgtatctt gcattccgtt 1720321 caacagcaag aaaatctgcg acgtgatata cccctttaac tccatctatt ttaaggattt 1720381 ccgctataac aagcggtgcg ccttctgctt gctcaggttt atagttattg cttttgcccg 1720441 ccggaagctc ttccgttaag atgactttca ttgtattcgg gcttggtgta ggttcaattg 1720501 attttatctt catgatcgtc ctcctatagc atatctgtga cttattctat catagtcgct 1720561 ccaagccttc tattacgacg tttcggcatc aatcccgggt atgtcttttt ctaattggcg 1720621 gacaaattga agcataaaat tgtgtctttc ttctgccagt tcccgtgcag tgtctgtatt 1720681 catcatatct ttcagccgca gcagcttatg aaaaaaatga gcgtaggcgc tttgctcatc 1720741 tccataaagg ccatgccctt ttgcgcccgc aaacatgaaa gctctcgcaa tgccgacagc 1720801 accaatcgca tcaagtctgt cagcatcctg tacagctttt ccttcaattg agagcggctc 1720861 cttcgccaat ttccccctgt cccgaaagga catccttgtt ataatatgaa tcaccctgtc 1720921 agcattctct tttcctactc cgaaaaaaac gagctgatca tatacttcgc tcacagaaag 1720981 cctgaccgtg tcaggcagct tcacatcaat taaatcatga accaaagccg ccgtttcaac 1721041 aatgaacaaa tccgcttttt ccttttctcc aatatacgct gcaagatctg ctactcttga 1721101 tacatgatgc cagtcatgtc cagagctttc gtcagtcagg atagattgaa cccatgtcct 1721161 gatttgctct gcctgcttca attccttcac aaaaacaccc tctttttatt gctctaatag 1721221 cttcacgata tcgtcttcca actctttcgg atttgtattt ggtgaataac ggccaacgat 1721281 ttctccattt ctatccacta taaatttcgt gaaattccac ttgatcgcct tagttcccag 1721341 catccctttc gcatgttctg tcaaatacac aaacagcggg tgggcgtttt tcccgtttac 1721401 atccactttt gaaaacatag gaaatgtaac accgtaattt gtttcacaaa attcctgtat 1721461 gtcagcctct tcaccaggct cttggttcat gaattgattg caggggaacc ctaagatctc 1721521 cagcccctcc tgctgatatg tatcatataa ttcctgcagc tgcttcaatt gggaagtaaa 1721581 accgcactta cttgctgtat tcacgatcat cagtaccttt cccgcgaaag gctgaagtgt 1721641 catgtctttc cctgtgattg tacgtacctt catatgataa atagacatgt aagtccctcc 1721701 tatgtccttg gtgctgatta ttttaccttt tttaaatcgc aattcaaaat gtaaacatca 1721761 attaagaact cataagaaac ctaacgatat gagcgtcagt tcattatcaa ttcatatggc 1721821 tcgtttttta tcttatcatt ctataaaaca ttacaattcc ctcttacatc tttgaaaatc 1721881 attttactgt gaaaccaaaa ggcgtgtcag tgcgttttat ttaaagagtt ttctgttgtt 1721941 tccccctcaa cacgtataga tagattgaaa attggcgtga aaattcctat aatgaagaaa 1722001 attaaacggg gaaataatgg aggtggcacg ttgcctatta atataccaac acacctgccg 1722061 gcaaaacagg tgcttgaaag tgaacatata tttgtaatgg atgaaagcag agcatttcat 1722121 caggatatcc ggccgcaaaa aattattata ttaaatttga tgccgaaaaa aatccaaaca 1722181 gagactcagc ttctcagatt gcttggaaat tcgcctttac aggttcattt cacattttta 1722241 atcccaagca cacacacgcc gaaaaatact gcgagagaac accttgacga attttacacg 1722301 actttttcca atatccgtca caagaggttt gacggcatga ttatcaccgg tgcgccgatc 1722361 gagcatttgg cgtttgaaga ggtttcatat tgggaagagc tcaaggaaat catggagtgg 1722421 agcaaaacaa atgtcacttc aaccttgcat atttgctggg gtgctcaagc aggtttgtat 1722481 taccattacg gtgtggaaaa aattcaaatg ccgaaaaaaa tcttcggtgt gttcgaacat 1722541 accgttcttt caaaacacga aagattggta agaggttttg acgagctata ctacgtgccg 1722601 cattcccggc atacagatat aaatatggaa cagcttcaag cagtgcccga gttaaacatt 1722661 cttaccgcat caaaggaagc cggggtttgc ttaattgtgt ctaaagacga aaaacaagtc 1722721 tttttgacag ggcaccctga atatgataca aatacgcttc ttcaagagta tgaaagagat 1722781 ttggaacgaa acctttctac tgtcgaggcc cctaaacatt attttgcaaa aggcagcaac 1722841 gagccagtga atcgctggaa agcgcatgcc acattattgt ttatgaattg gctgaattat 1722901 tacgtttacc aagaaactcc ttatgaatgg gactaatttt tcttttttta gtgatacgct 1722961 gagcaaaaaa tatgataaaa tacatctgat tcagtctgcg tataacaaaa atttaaaata 1723021 ctggaatcca aatcatttaa aattagctta actttttcac tgcattaata attcgattat 1723081 gtatttgtgt tatgtttatg tatagacaat aactccttac gatgcatgaa gcttgcttgt 1723141 tgttgattac attgaggtga atttacttga ataccaataa aagagtatta attttgactg 1723201 caaattacgg aaatggacat gtgcaggtag ccaaaacact ttatgaacaa tgtgtacggc 1723261 tcggctttca gcatgtaaca gtttctaatt tgtaccaaga gtcaaatccg attgtttcag 1723321 aggtaactca atacctttat ttaaaaagct tctcaatcgg gaaacagttt tatcgtttgt 1723381 tttattacgg agttgacaaa atctataata aacgtaaatt caatatttac tttaaaatgg 1723441 gtaataaaag attgggcgaa cttgtcgatg aacatcagcc cgatattatt attaatacat 1723501 ttccgatgat cgtcgtgccg gaatacagac gccgaactgg aagagtcatt cctaccttca 1723561 acgttatgac tgatttttgt cttcataaaa tttgggttca cgaaaacgtg gataaatatt 1723621 atgtggcgac agattacgtg aaggaaaaac tgctggagat cggcactcat ccaagcaatg 1723681 taaaaatcac aggaattcca atcaggccgc aatttgaaga atccatgcct gttggcccga 1723741 tatataaaaa gtacaatctt tcaccaaaca aaaaagtgct tctgatcatg gcaggtgctc 1723801 acggtgtatt aaagaacgta aaagagctgt gcgaaaacct tgtcaaggat gaccaagtgc 1723861 aagtagttgt cgtgtgcggg aaaaatacgg ctttaaaaga atctttgagt gcgcttgaag 1723921 cggaaaatgg tgacaaatta aaagttctgg gctatgtgga gcgcattgat gagctatttc 1723981 ggatcacaga ttgcatgatt accaagcccg gcggcattac tttgacagaa gccacagcca 1724041 ttggagtgcc tgtcattctg tacaaacccg tgcctggcca ggaaaaagaa aatgcaaact 1724101 tctttgaaga ccgcggagct gccatcgttg tgaaccgtca tgaagagatt ctcgagtcag 1724161 tcacttccct tcttgcagat gaagatacct tgcatcgcat gaagaaaaac attaaggacc 1724221 ttcatttagc aaactcctct gaagtgattt tagaggatat cctgaaggaa tcagaaatga 1724281 tgaccgccaa acaaaaagcc aaagtgctat cgtaatggcg tacttgagag catacgaaaa 1724341 tcgtgtgctc tttttattta tattcagcca tcaataaaag cggttacatt tttttatgga 1724401 acttgccctt cttttgaaaa ataagccgtt tcgcaacttg acgggtgctc ccagatggtg 1724461 tatagttgaa ccatcattta acaatgaatc aaagttagat gatgacaaaa ttttttttag 1724521 cacatgggtg ctacagtact aggaggaatt aagcaatatg caaaacggta aagtaaaatg 1724581 gttcaacaac gaaaaaggat tcggcttcat tgaagttgaa ggcggagacg atgtatttgt 1724641 tcacttcaca gctatcgaag gagatggata caaatcatta gaagaaggac aagaagtttc 1724701 ttttgaaatt gtcgaaggta atcgtggacc tcaagcttct aatgttgtaa aactctaaac 1724761 tcaatacatg atgatgagat gacaaataga ggagaggcat tcgcctctcc tatttgattt 1724821 tcatctggat ttcaatcgcc aaaatgtttt gtttacacct ctgttcaatc tcttcaacat 1724881 acttttccat tgatggtttt ccttttttcg cgatatcggc cagttcttct aaatcactgt 1724941 atatttctat aaatgttttg tgaaggatca acttcaagtc tttatcatcc atagctgcgt 1725001 tccccttctc tatcaagata cctcaaatag taaaacggtc ctatttattc tggttcaata 1725061 gttatatcgg cttattttta ttttcttttc tattttggta cataaatttc aaaaaaactc 1725121 tgcaaaataa tggcggaggt gttttttgtg acttcagaat ttcataatga ggatcagacc 1725181 ggctttacgg ataagcggca gctggaacta gcggtggaaa cagcgcagaa aacaacagga 1725241 gccgcgacga gaggccaaag caaaacatta gtcgactctg cataccaagc cattgaggat 1725301 gctagagaac tgtcacaatc tgaagagctg gcagctctcg atgatcctga atttgtaaag 1725361 cagcaacagc agctgctaga tgacagcgag catcagctgg atgaattcaa agaataaaaa 1725421 ccgcagcttc tgcggttttt atttttagtg attggttaag acatctccgt attgtttcaa 1725481 cttttcacca accgtacatt tattgataca aaatgaatgc gcataagttt tgccaaattc 1725541 tttgcgaaac tgcttcttaa taaaacagtc cttgcaatat tcatcgtgca gttctgtcag 1725601 ttctttaaag atcattttct tatccaatat cgtcatctcc gttacggtct aatttcgtgt 1725661 ggctttctac gaattgatgg gatagaattt ttttagcgag gccgtcagct tcctgattgt 1725721 cttttcgttg tattgtttcg taggttggag taagcttcag cgattcaagg agtgcttcta 1725781 ttttgtccag ccattcatta tgagatggat cataacaagg ccagctgccg tcaagctgat 1725841 tcagcacaac aagcgagtcc cctttgattg taattgaatt tctgcttgcc ccaagctctc 1725901 ttacttctct tattgcttca taaagcgctg cgtattcagc ttcattattg gttttcagcc 1725961 ggaagctttt attttttctc aagcgatgcc gggttcctcc caatgaataa tagatgacga 1726021 tcccgagacc ggccagttcg ctctctttat cgaaactgcc gtcaaaataa acagtaatgt 1726081 catcaggctc ttgagcaagc tcctctgtca gcttttccaa ttccttcagc gtccagctgc 1726141 cgcctttctc gtcttcgaac tctagctcct tcatgtatgg aaaacggcca agttctctgg 1726201 cgaacgtacg tgcctgctgt gctgtcagcc agtcttcgct aaaaaatgag acggatcccg 1726261 ttccttttgc ttctattttc aaatgcggtc tgagcttcat tacaatcacc ttaccattca 1726321 ttagttgccg ggcttatgct ataatcaaac caatcttacc ccggaaagga agctttttca 1726381 tcttgtttaa taattcgttt tggatctttt ttgcgatcat tcattttatc attgttcttt 1726441 tattttataa aggatttggc aaaatgggac tgtttgtttg gatcggtttt gcgacagtct 1726501 gcgccaacct ccaagtcgtc aaaacagtcg aactgtttgg cttaacagcg acactcggga 1726561 atgtgatgta tggcacaatc ttttttgcga cagatgtgct gaatgaaaaa tacggaccag 1726621 ctgaagccag aaaagcggta tggctcggat tctcaacgct cctgacgctg acatttgtca 1726681 tgcagggcgt gctgcttttc gaaccggctt ccagcgacat atcacaaaca gcgctggaaa 1726741 cgatcttcgg attccttccg cgagttgcgt taggaagtct gcttgccttt atcttcagcc 1726801 aaacgctgga tgtttatgta tattcggcaa ttagaaggat atttccttct gatcggcttt 1726861 tatggctcag aaacggcggc agtacagcag tcagccagtt gtttgataca ttcatattca 1726921 ctgcagtcgc ctttctcggc atttatccgg cagacgtgtg gcttcatatt tttatttcta 1726981 catatttgat taagtttgcg gtatctttaa tttcattgcc ttatgcctat gcagccaaaa 1727041 aaatgatacc taatgatgaa aggagttcat aatgcctaca gaaatatatg tagacggcgc 1727101 aagcgccggt aatccagggc cttccggtat cggcattttt atcaaacatg agggaaaagc 1727161 agaatctttc tctattccaa tcggagtgca tacaaaccag gaagcggaat ttcttgcatt 1727221 aattgaaggg atgaagctat gtgcaacgcg cgggtatcaa tcagtttcct ttcgaaccga 1727281 ttcagatatt gtggaacgcg ccactgagct tgaaatggtt aaaaatataa cgtttcaacc 1727341 gtttgtagaa gagatcatcc gattaaaagc ggcattccct ctttttttca tcaaatggat 1727401 accgggcaag caaaaccaaa aagccgatct tctggcaaaa gaagcgattc ggctgaatga 1727461 aaagaattaa atcttgatca ttggttcatc ctaatggcga ggtgaactaa catgaaaaag 1727521 aaagataaag gccggctgac cggcggtgtt actccgcaag gcgacctgga aggcaataca 1727581 cataatgacc ctaaaacaga gcttgaggag agagcaaaaa aaagcaatac aaaacgctag 1727641 agaggatcta aacgatctct ctagcgttca gcttttcaag catacgctca attcctttaa 1727701 tttggtggcg gcgaagcatg tcagccgcct gctccatttg caaagtaaat aaagcgtctt 1727761 tcagtgtgca ggccagcggc actgagcaat ggatttccgc aagcttcctc gacatctcca 1727821 aatcgcttaa accttgctga atttttccct gctgtccttt tggaagaaga gaaagatttt 1727881 ccaataaacg gtcaatcgtt tcgtattcac gaatcagttt gtaggctgtt ttttctccaa 1727941 tgcctttgac tccgggatag ttatcactgg aatcacccat aagcgcttta atatcaatca 1728001 aagccttcgg cattacgcct gtttcttcat aaaaagtctc ttttgtatag actttataat 1728061 ttccgattcc tttttgaagc aaagcaacgc ttactttatc cgttaacagc tgaagtaaat 1728121 ctctgtcccc tgttaccacc gtaatgtccg cttcattcgc aaataaatcg gcaagagtac 1728181 cgatacagtc atccgcttca tagccggcaa agccaatatt catgattcca agctctgcgg 1728241 ctgcttcctt tgccaaatca aactgcggaa tcagctccac aggcggcgcg ctgcggttgg 1728301 ccttataatc ttggaacaag tcatttcggt acgttttgct ccccatgtcc cagcagcaga 1728361 cgacgtgtgt cggctggaat gtttccacag ctgtaatcaa atgctttaaa aagccgttga 1728421 cgccgttcgt cggcaccccg ctgtcattta tcataaagtt gcgatgtacg gccgtggcaa 1728481 aaaaggcccg gaataaaaga gccatgccgt caaccagcaa tagtttatta ttattcatca 1728541 aataactccc ttttctttca ttccttctat tttatcataa agcagcccaa aaataaaaaa 1728601 cagtatctct ttaattagag atactgtttg aatatttatc aatcgttgtg tcttttgttg 1728661 ctggcgatca gcttttcagc ttcgcgtcct gcgtaagagt caaaatgggt ttgaaatccg 1728721 tttttctttt tggcgttgtt attcgcctgt gcatttctgt ttccgagctt tgttctgccc 1728781 aacatgaatc cccccttacg tcggatgcat atagtatatg cttccggcag gaggttcact 1728841 cgcgacagga tcatccagct tacatgcggc ttacgtattc tctgaccatt tcttttgata 1728901 caagccgtct tgtcgggacg atgccttttt tagcgagctg attcatttgc tcggtaattt 1728961 cattaattgc atctgtagta taaggctcat cgtttctgca tttagcaaca gcttcttcaa 1729021 tcgccaattc acgcatattt tcaagacgca taaatgcttt gatatgctcg tgctgttttg 1729081 atgaatgtgc tgaaattgct ttatgtacct ctgacattaa tcgttcatct cgcttttttc 1729141 tatttagtct atcatgactt gaaatacaag ccaactgaat tttacatttt tattgtattg 1729201 tctgaatttt tccaggagat gcacgcctga tacgccattt caatctcttt cgcatgttcc 1729261 ccttccgcat atcctcttaa atatgtctct ttttgatccg ttatttgcgc gattgctttt 1729321 tcacccatat cttcctgtaa gcgtctgagg tgagcagtgt aatgagatat caggctttct 1729381 tcttcatttt ttatccatgc ctctgtgatt ttcgtaagtt tcatccgtac agcttcgata 1729441 aaggtcgctt ttcctttctg ctcaaaaaac tgcttcggtg atttgatctc ttttagttcc 1729501 tgctcaaaag cacgttcttc tatttccggt tcaacttcct tcaactgtat gccgttcgaa 1729561 tgctgatcac ccgcataaac ggaaaaataa ccgtcctcgt ttaatgtttt ttgaaaatga 1729621 tccagccatt cttcattgat atgccgttcg atgaaaccgc tcatgcgaac atcaagcgtt 1729681 ttgatttcct gaatatattc aaatagatat tcatgtaagg ctgttgtcat cgctttactg 1729741 acgttctttt tccaatcccc gttttgcagc ccgggatgaa atgccgattt taataaatca 1729801 tttgcaaaat atgataatcg ctgtgcaatg tgatatagct gctctcttgt atcttttttt 1729861 actttttcaa tgatggtttt tgagttccgc cgtttctcga tatcggccgc tgtccgctca 1729921 aatgacagca taaggcactg tttctgcgct tccttctctt ctcgggactg atgctgggat 1729981 tggtgaagct gaaaaacagt ttcgcatagt ttgtctgcct ccgaactgag ctgcgctgct 1730041 gacgcttttt ttacatccac ttcgataaac cggtctaagt gttttcttac tttcgagaac 1730101 tgattataaa atgactccgg ttttcccacc agttcctcct tacttgatac ggtaaagagc 1730161 tgcggctcat aaaccccttc ttttacaagc tctgcgctga cataatcggt cactgtttcg 1730221 agctctgttt tatcttttgc aaggtctgca gcattaataa taaaaaacat tttatccatg 1730281 ctgagcgatt ctttcacaag tccaagcttt cgcaaaaatg aacggtctcc ttttgaaaaa 1730341 gagtgctgat aataagtcat ataaaaaaat gcatcagcat ctttgatata ttggaatgcc 1730401 agttctgtat gccgtttatt catgctgctc gcgccgggtg tatcaacgat cgtaatccct 1730461 ttttcagtga gcgggcatgt atagtagacc gttacctctt tcacagcaca ggccgttgtt 1730521 tcctctgcta catacggctt taattcagag agcggaatcg ttaatttctt ctgttcctgt 1730581 atatactgct gatacttctc gtatgcaagc aggaaattgc tgatcaattt cacgtgttct 1730641 tcctgcagcc tgtttttttt gactgccttt tcccacttct ctgtgaagga acggcctgcc 1730701 ggctcctttg gtattccggt gagctgcaaa atttcagccg ttaagtcatc ctctgtctta 1730761 aacactacat tcgctgtttt gtttaagttg ccattgattg gctttgtgat cttgttaatt 1730821 gtcgctgtgg ttggcgttgg tgaggatggc agcactcttt cgccgacaag cgcattggca 1730881 aatgatgatt tccccgagct aaagcctcca aaaagagcga gtgtaaattt ccgttcctca 1730941 agccttttca ccctttcacg aaacgctgaa gtttgcttta acaacatgct gcattcgcct 1731001 aaaatgtcag acaaagtgta aaagcgtttg atttggtctt gaagcggcat ttcttgttcc 1731061 attttgattt ctgatttcgg catcggctgc gccgtcagct ggcttcggcc ttgtttctgc 1731121 tctggagccg ccactcttgt tttcttcgat ttaaaccatt ctgtgtctat atgcattggg 1731181 catgcggact cttcttccca aatggcccac aggcgatcgg ttttctctcg ggcattattc 1731241 tctaaacgtg cctgttcttg aagaaagaca agtttttctg attcttggac gagccggtcg 1731301 ttaattgttt gcacatcttt ggaaacacgc tctttcacca tagcggagag cacctttatg 1731361 atgtctgcgg cttctctttt cgcctctttc cggatgagct ctgccaagtc ttttgtatat 1731421 tgcaatacat attcagagga aaaggctgca ccatgcttga ccgcgtgttc aatgatgctt 1731481 atatcaagcg gtgtgcgata ggcctgaatc agcttttcac tttcagcggt atagacatca 1731541 aataccttgg cgagtttatg aagcgtgtct atcatatgcc aatccgcttc ggcctctgtt 1731601 cgttttgcca catcagagaa aaaagcattc cgccttttat ctctttcctg tgcagttttc 1731661 gctttagaaa agaaaaagcc ggttttaaag gaaggctctt gtgattctaa aaatgcagcc 1731721 gccaattcac gcatttcaaa aggcgtcagg ttggcgtttt ttaaaatacg attgatttct 1731781 tcctgcatcc tcttctctgc ctcagtcatt tgtttttcgg cctcatccaa ttgatcacgc 1731841 agcgattgga ccagtccagt atggatatta agctgttcag cgaaactcgg agcgcctgtt 1731901 tcgtctttct tcagcatttc cgtatgttcc tttagcagat tacggacttt ttgttcggtt 1731961 aaagcctgca tattgctttt tgattgctgt tctattctgc ttaactcttc tctcagggcc 1732021 cccatctgat tgaacgggtg atccggttct gttactgatg taaaatagag cgcttccctt 1732081 gaaatccctt cattgcaaag catctcctct acctgcgctt gatagtctcc aaatttcgtc 1732141 tccgtctcat catggcggtc aatttgattg acgataaaat acacattcgg aatgctttct 1732201 tttattgatc tgagaaactt tacattttcc tcagcgtgca cgtgattata gtgaacgacg 1732261 taaaacagcg catccgcttg gtgaagaata gaagcagccg atagaaaatg cgcatcatct 1732321 gttgaatcta tccctggagt atcaatatac gcaaccccgg aatcgatctc agtatacctg 1732381 tcaaaaattt cgacgctttc aatctgttcc ccgtctttac aatattgctg caccttgtct 1732441 ttctggtaag tcccttccag ctcagcacac gctccgtctg ttgtatgaag ccgaactcgc 1732501 ttttccccgt ttctgatcac aacaaggtta gcgcttgtcg gaatcgggct tgtcggcaaa 1732561 atattctcca ttaacaggca gttcagcagt gacgatttcc ccgctgaata atgcccggta 1732621 aacgcgatat aaacctcttc atcagccgct tttttcatga ccgcagccag tttagcagcc 1732681 ctttgttcat cttgattctc aataaattgc ttataaagtt ccccggtttt atgcaaaagc 1732741 tcttttctgt tttgatctgt cataagtctg aacccctttg tgccgtttca attgtgaacc 1732801 tttttcgaaa gatctgaatt cattcccttt tcattttaca caagaataaa ccaaatttct 1732861 ttaggagaat agaaaaaagc cgccattacg gcagcttcta taaaagaaaa tctgcaactt 1732921 ttacaagttc cagattcatc aaacagattt attagagatt ccttttaata caaaaccaat 1732981 taatacacta tatgtacaaa ccgctccaag caaaaacagc attgtcattt gcttcaccat 1733041 cctgattgag aatctttttc aaacccattt taacatggtt gagaatgatt ttcaatcgct 1733101 attttacgct gtattcctgt aatgctttgt cttctgcgcg aattctgacg cttaacaaca 1733161 cggcattgaa aatggaaaac agacacatgg tgacgtatgc ttgataaagc agcggaatca 1733221 gcaaaatttc gaggataaca acggcatagt ttggatgttt catccattta tatggacctt 1733281 tttttacaag ctctacacct ggaacaacaa ggattttcgt attccaatat gctcctaagg 1733341 aacaaagcgc ccaataccgt acgatctgta cgcttaaaat cactgcagcg ataccgagcc 1733401 accagctgga cggctgttta ttcatcagca gcacctcggc aattaaggac aggaaaaaaa 1733461 ggatatgcat cgtaatgata tacggatagt ggctctcgcc aaattcaatt gctccttgct 1733521 tctttacctt ttgttcgttt tgcctggcca ctgccatttc tgctgctctt tgaacaatga 1733581 gaatggcgat caacaaccaa aacatgagtc aggccccctt ttcccagctg aataatagca 1733641 actctgatga gaaacccggc cctaatgcgc caatcagtcc tcgttcagct tcctttttat 1733701 gtccgttctg cagatggtct ttgatcacat acaagattgt ggctgaagac atatttccgt 1733761 gcttttgcaa aatgctttgc gcagatgaaa gcttttctga cgacagcccg agacttttga 1733821 tgtatgcatc gatcactttt tttccgcctg gatgcgccaa aaaaacactg atatcatgga 1733881 atgacagctt atgtttgtcc aaaaaaatct gtacatttgt tttgagccat ttttccacca 1733941 aggtcggaat gtctcgtgag aaaatgactt tgaatccttg atcggtaaag tcccagccca 1734001 tgacatcttc tgattgtttc atcaaaacag attgggcgtc cattatcttc ggcgcaagct 1734061 tcagctttga caccctgcgg tccgccttct ctccgcataa taaagctgcg gcaatgccgt 1734121 caccaaaaag cgaggtgccg atcagattgc tttttgtttt atcttccggc tggaatgtca 1734181 ggctgcacag ctcggcagaa atgacaagca caaaagcctc aggatacgct ttgcagtatt 1734241 cggctgcacg cgcaagtccg ctggctcctc ctgcacagcc aagcccccaa atcggaatcc 1734301 gcttcgtata tggagaaaac ggaagttcat tcataagccg cgcctcgata ctcggtgtgg 1734361 aaagacctgt actggagacg aaaaaaacag cttccacttt ctcataagga atggcttctt 1734421 gaaaaaattc cggatgagag aggcactcac gaacagccgc tctgctgtgt ttaagtgttt 1734481 cttctatgta tatttgattt ttttcttcaa agctgtgccc ctctttatac cattcaatcg 1734541 gcttaacaaa ctgtctcgaa tggatttgcc cgtttttaaa ggaggataac agcctgtcaa 1734601 tatccttaaa agaatgctga aacatatagc gggcgaactc ggccgctttc tcttggttta 1734661 cattatacgc aggaagactt gttccaatgg ataaaataaa cgccatgcga tcacctcttt 1734721 gcatacattg tgccgcaaca atctttttta tatgcaaaaa aaactccgcc gcggcggagt 1734781 tagactgctg ttttttgttc agcgaggtca gcttcttgtt ctattttttt agctttagaa 1734841 aaaacgttat atacaatatt taagacgact gcagtaaagc tgcccgccac aatgccattc 1734901 gttgtaagca gcgttaaggc actcggaagc tgtttgaaaa tatccggcac aacggtcaca 1734961 ccgagcccca atcccactga gcaagcaaca atcagcagat tttcctgttt cgcaaaatca 1735021 atgcggctga gcattttaat tccgtaagca atcaccattc caaacatcgc caccattgca 1735081 ccgcccaaaa cagcggatgg aataatagtc gtgaaagcag cgatctttgg aaacagccca 1735141 aatgccatta ggatcacacc tgtgaccaca atgacggcat tttttttgat ccctgtgagc 1735201 tgaacaagcc cgacattttg agagaatgcc gtgtaaggaa aagcgttaaa aataccgccc 1735261 agaagcacag ccagtccttc agctcgatag cctttagaca aatctatctc tgtcaaacgg 1735321 cggtttgtca ggtcacctaa agcaaagtaa acaccagttg actccacaag gctgacaatt 1735381 gcaacgatgg acatcgtaat gataggcgct gcgtgaaaag acggcgctcc gaagtaaaat 1735441 ggctgaatca tttgaacaac tgccgcgtcc gaaacattat caaattgaac ttttcccata 1735501 aaatatgcga tgaaggtgcc aatcaaaata ccgatcaaaa tcgagacgga cttgataaag 1735561 ccttttgtaa aacggtatag aagcacaatg atactcaaca cggtaaaagc aagtgcaaga 1735621 ttggagagat ctccgaaatc tgcacttcct tctccgccgg ccatgttatt catggcaacc 1735681 ggcatcagtg taataccgat aatcgtaaca acagagcctg tcacgaccgg cggaaaaaac 1735741 gatacgagct ttccaaagaa aaatgaaata agaatgacaa gaatgcctga agcgataatg 1735801 ctgccgtaaa ctgttgaaac cccatattca gatccaatcg ctatcatcgg cgatacagct 1735861 gtaaaggtac agccaagcac taccggaagc ccgatcccaa aaaatcggtt gctccacact 1735921 tgcagaagtg tagccacacc gcacataaaa atatcaatcg atactaagta agtcagctgc 1735981 tcgacagtca gtcccattgc ttttccgaca atcagaggaa cgacaatggc gccggcatac 1736041 atggcaagaa catgctgaat ccctaaagac agcgttttgc cgaatccatt tctcatgaat 1736101 gaacctcctg tacgaaggac acttttcctt cttctaaaga ctgaattctt gccaaagatt 1736161 ccactcggta gcccagtttt acaagttcat ctcttcccgg ctgaaatgac ttttcaataa 1736221 caatgccgat tcccgcaata gaagctcccg cttgcttcac aatcgacaca agcccgtgcg 1736281 ctgcctgtcc atttgccaaa aaatcatcga taatcagcac atgatcctga tccgacaggt 1736341 gggtcccaga cactgcgatt tggctttctg tttgcttcgt aaaggaataa acagacgctg 1736401 tcagcaagtt gtcggtgagt gttaacgatt tatgctttct cgcgaagaca actggcacac 1736461 ccagcttcaa gcccgtcatt acagcgggag cgatacctga tgattcgatt gtcacaattt 1736521 tggtaatacc gtcttttgca aacctagacg caaattcatc accaattctc tgcataagca 1736581 gcggatcaat ttggtgattc aaaaaagaat ccactttcaa tacctgatca gataatacga 1736641 cgccttcttc ctctattttc cgtttcagtg cttccatcct gtctacctcc gttatgagaa 1736701 taaaaaaagc attgcccgct caaataaaga gcaagcaatg ctgatatcac aaaaaaccgt 1736761 acacgtgcgg ttccattgct cacccatagt cggacattta cggtgcccgg tagaaacttg 1736821 cgtgccatat ccacgcgatt atatgagtgt tcctattata ttgtaataaa ttatatcaag 1736881 attctaatct cttgcatagg ctgaaaataa aaattcccga actttaattt tgttttttta 1736941 gatatcattc gtatttcaag gggattcgat ataaaagagt ctgacgaccg cgccgccagg 1737001 cttttgatta taacagatag agatttgaat atttgtttga taaataatca attaaatagc 1737061 gaacattcag ctcttctcct gttgcatctt taataatgtc taacggcttt ttccgttttc 1737121 cgtgaatgtg caccttttcc gtcagccatt gctttatcgg atggaactct cctctttcca 1737181 agagagcgtc aaattcaggg agatcctcaa gcattttttg tttcagctga gccgcataca 1737241 tgtagccgag cgcataggat gggaagtagc cgaaatctcc acctgcccaa tggacgtcct 1737301 gtaaaatccc ctctgcgtcg gtctgcggtg taatccctaa ataatcctgg tatttttgat 1737361 tccaaagcga cggcagatct tccacagaca cttcattgct gaaaatcgct ttttcaattt 1737421 cataacggat gatgatatga agaggatacg tcaattcatc cgcttcgacc ctgataaatg 1737481 aaggttttga ttcattgatt gcccggacaa aatcatccag ggagatgtcc ttgaactgta 1737541 caggtgatgc ctcttgaatc ttcttatagt acggagtcca aaaatgcttg ttgcggccga 1737601 taaaattctc gtaaaataat gattgcgatt catgaattcc catcgatgcg ccgtctgaca 1737661 agttcgtgcc actgagtgct tcatcaatat tttgctcgta aatcgcgtgc ccgcactcat 1737721 gaatggtccc aaagatcgcc gtccggaaat ctttttcatc atatctcgtc gtgacccgaa 1737781 cgtctccccg attcagcgta gttgcaaacg gatgaacggt ttcatcaagt cttccgccat 1737841 caaaatcgta gccaagctcc tgtaaaaaat acagactgag ctctttttgc ttttctttcg 1737901 ggaacgcttt tgtaataaag cttgtatctg gtttatttcc ggaagctgtc acctgtttaa 1737961 caagagggat aatcgcttcc ttcagctcag caaacaactg atcaagcacc tttaccgtga 1738021 cgccgggctc aaacaaatca agcaatgcat cataaggatg ctcttgatat ccccaatacg 1738081 taataaaacg tttattgaat tcaatcagct gttctaaata aggagaaaac aagctgaaat 1738141 cagattttcc tttcgcttcc tcccacgctg tttctgcctt tgaacacaga atcacgtatt 1738201 ctttgtattc agcctcaggg attttcttat tctcttcata ctcttttttc gccagttcca 1738261 ctgctttttt cgtatcttcc gacaagtcat caaatcgttc atacaggaca tcgataagct 1738321 ccttcattcg atctgatgtt tggatattga atatatctgt tgaaagctgg ccgatacttt 1738381 cggcacgatc ctctgagcca tttttcggcg cgcctgttct ggagtcccag tgcattaacg 1738441 caactgcttc gctgtaatgt gagattcttt ttaaaagatc aaaaaattct ttttcatatg 1738501 tatgtatctc catatccatt ccctccctat tctagccgtt ccattacagg ctaatggaag 1738561 ggggtatgaa agtcaaattg tttgtataaa aggctgccgg tatgttttgt ggcagccttt 1738621 ttattcagtt gatcgtcatt tgattttttg gcggaggtgt tctccgcttt ttctgcttga 1738681 tttttttatc tacccacact gttgccagcg gggttaagag cgaggtgaca ataacgcttg 1738741 tcgcgataat tgcagttgcc gactcagcaa ctggcgcaaa tgaggcattc gcttccgcta 1738801 atgcatatgg cacggctaca gccgcccctg ccgtagaaga agcggccact cccgcgacac 1738861 catctccccg cgcaataaaa cgatcaagca aaaacaaaga actgcccgat aaaatgacga 1738921 cagaaactcc gataaaaatg ccgagcagcc ctgattggat cagcattcca aaattcaagg 1738981 tattgccgag cgaaaaggcg aaaaatggaa tgatcgccgg cacaaccttg ctgaataagt 1739041 ctctgagatc atgatccaga tttccaagta tacatccaag taaaaacggg atgactgtcg 1739101 ctgccagcgt ttcccatggg aatgcggcaa gtcccgtcac accaaacgtc accatggtca 1739161 taaaaggacc agattctgta ctgataaagg cgaaagcgcc cgcatcctct tttcttccca 1739221 tgtgattcat gagcgccaaa tacagtccgc cgttcgtttc attcattacc gcgacaattg 1739281 ctaaaacaga aaggcctgca aaaaagccgg attgtatgcc atcgtcaggt ataaattgcg 1739341 ctgcgatcac gccgagcagc gccgcaaatc cgatcttccc caataataac gtgattcctt 1739401 ttcttgcgat atagcctgaa gaacgaaaat caatcgttgc tcctacgcaa aagataaaaa 1739461 cacccagtat cggcagcgtt ccggtaatca aagcacccgt aaaccctcca aagaactccg 1739521 ctgttccagg cgcaaacgtg ttgagcgccg ctccaagaaa tagcggaata atcatcattc 1739581 cgccaggtac ccgttcaatt gtcgccttga ttttcatatt gtggattctc ccatcctccg 1739641 gttatgaaaa aacaattcca cttacacttg gaaaacagcc tgcaaatcct cttttgaaca 1739701 gctgcccaac tggctgccga ctccgacggc gccagctccg gctctaagcc aatcaggcac 1739761 ttcagacgga tgtatcccgc ctgtcggaat aaaggtcacc tgcgggaaag gacccgctaa 1739821 atttttcata aacggaatgc caaacacacc gcttgggaac agctttaatg tcgtaaaacc 1739881 gaatgtcagc gcttccataa tttcgctcgg agtcaagacg ccggggatat aatgtgtctt 1739941 tacaaaagat agatgttcag caagatcagc tgaaaaaccc ggactgacaa taaactgcgc 1740001 gccagcctta gcagcttccc cagcttgctg cgcgctgatg accgtacccg cgccaattaa 1740061 aatatcttcc ctattacgga aggattcgat aatatctgat gccccggggg tcgtatacgt 1740121 cacttcaact gcacgaatcc ctttatctaa taaactctca atctgctgac aggcctcctg 1740181 cttatccttt gaacgaatga ctgcaatcag ctttgcttct ttcagacggt tttcaacgac 1740241 tttggactcc atattaataa tcccctttct tttggtgaac cgttctttga gcagataaaa 1740301 aagaagctaa tttctccctg gtcggcaaac cgtccatatc ccccggtgcc tgcacttgca 1740361 aagcgccaat cgcatttccc ctttgcaccg catccttgta cgacaaaccg tctaggatac 1740421 cgctgattac accgactgca aatccgtctc cggcgccgac cgtatcaacc acccggtcga 1740481 cccggcagcc ttctagaaat ccttcacttg tccccgtttt aaagtaagcg ccttcttttc 1740541 caagtttaat agcaacaaag ctggcacctt ttttcaaata atagtcggca atgccttcag 1740601 gtgttttttc tccggtcaat agctctccct ctgcgatacc cgggaaaaac cagtctgcaa 1740661 gcccagccag atcattgatt gtgtgtacca ttgttgcttg atcaggccaa agcgaaggtc 1740721 ttacattagg gtcgaatgaa atggtcttcc ctgcgtttct catgtcgttc atgacatgat 1740781 acgtgaagtc tttcatctcg gctgataaag caggcggaat acctgtcaca tgcaaatggc 1740841 ctgcgcattg aaaataatct ctcggatatt cagctgtagt taatgtgctt gcagctgagt 1740901 ttttcctata gtaggtaact tgcgggtcgc cttctttcac ttttgacttc agcagcagcc 1740961 cggtgggatt ttcgtcctgc gagcggatca cgcgggacac atccactccc tcttttttaa 1741021 gctcttgtaa aataaacgtt ccgagctgat cattgccgac cttgctcatc catcccattc 1741081 gaaatccgag tctggcaagg ccgcaggcga cattgctttc tgctccggca agccctttag 1741141 aaaaagtgga tacttcatga aggcctccat actcatttgc ataaaacatg gccattgatt 1741201 ccccgaatgt caccgcatca agcttcatct cttcccaacc tcctcttagt tgagggcacc 1741261 taggattaaa gtgactttct catgatgact tttgcctcta attcaatggt ttgaggcgct 1741321 cctttgtcac cttcaatcct ttttaataca cgttccatcg ccgtcctgcc catatcatgt 1741381 gacggctggg cgatcgttgt aatgcctgga ccgatcagtt tgtaccactc cgtatcatcg 1741441 aatcctgcaa tccctatatc ttgagggatg cgcaggccaa gctcttccat acagctgatg 1741501 attttcagca taatcaagcc attcaaagcc agaatcgctt ttttttgctc cggcatttcc 1741561 ttgtgaaaag aacgaagctc cgccttaagc tgctccttgt cctttacgtc aatttcatgc 1741621 aatctgacaa gcccgttcac attttgaacc gaagccattt cctgatacac agctgctctt 1741681 tctgcacgag ggctgataga ggaaatcggt tcggtaaaca gcgcgacatc agtataccct 1741741 ttgctgtaca ccttctgaag aatctctttt gtgatccatc tgttgtcagt cgttacggta 1741801 tccagtttca gatccggcag tttccggtca attaagattg ttggaatttg ctgttcagca 1741861 aaagcgcgga gtacatcctt gttttcccct gttgcgttta aaatcaagcc ctcaaccgaa 1741921 tgggcttcta gctttaagag catttcccgc tctttttcag gactgttatc tgtgttgcac 1741981 accataatgc tgtatccata ttgatcacaa acctcttcga ctcccctgaa agcagcgacc 1742041 gaaaaaggat ttgtaatgtc agccacaaca aatccgatta acttgctttt ttttattttc 1742101 aaaccttgtg ccattttact cggccgataa ttcaattctg cgattgcctt tttaatgttt 1742161 ttcacttttt caggagaaat cgcgtcaatt tttccgttaa tatagcggga aactgtcgat 1742221 ttcgaaactc ctgcacattc agctacgtct ttgatggttg tatggcctgt tgttttcttt 1742281 ttcattcaag tgctcctgta tctcatatat ttgaaaccga tttcaaaacc gttacaacaa 1742341 aagaatacca taattttaaa atttgggaag agttttttta ataatatgtc aattcattat 1742401 tttttcgttg actcttttca ctatttatcc taaaattttc tttgaaaccg ttaccaaaat 1742461 attttcattc aagtgatgct gaaatcctaa ccaaggggga aatataatgg aaaatcgtta 1742521 ttctgtacat cctgaacaag taaaacgctt tacaacagag gagcttcgca gtcatttctt 1742581 aatggattct ttatttacag aaaacaaact tacgatgtat tactcacatg aagaccgggt 1742641 tgtcatcggc ggagcggctc cagggcaaag tgaactgaag cttgatgcag gtgattttct 1742701 aaaaacagac ttctttttgg aacggcgtga aatcgggatt attaatgtcg gccagcctgg 1742761 tgccgttaga gtcggcgatg atgaatatgt gcttcaaaca aaggattttc tctatattgg 1742821 aatgggcaat caggatgtat cgttttcaag cctgaacggg gaaaaagcga agttttactt 1742881 cgtctccgct tgcgcccaca aaagctatcc gacacaaaaa gccgccctat ctgaactgac 1742941 accggaccgc cttggtgatg atgcagcgtc taatgtcaga agtctgtaca aagtcattca 1743001 tcaggatggc attaaaagct gtcagctgat gatgggaata acgatgttag atcaaaacaa 1743061 caactggaat accatgccag cacacgttca tgaccgtcgg atggaggctt atctttatct 1743121 ggatcttgaa aaggactcaa aggtatttca tttcatgggc cagccggacg aaacacgcca 1743181 tcttgttgtt ggaaatgagc aggctgtcct ttctcccgct tggtctattc attctggcgc 1743241 aggaacatca aactatagct ttgtgtgggc gatggctgga gaaaattaca catttacgga 1743301 catggatctc attccaatgg atgggctgaa ataagatggg ttatctacat gacgcctttt 1743361 cattaaaagg aaaaacagcg ctggtgacag gcccgggaac agggatcggt caaggaatag 1743421 ccaaagccct agccggggct ggcgctgata ttatcggcac atcacataca agcagtctgt 1743481 ctgaaacaca gcagcttgtg gaacaggaag gccggatatt tacatctttt acattggaca 1743541 tgagcaagcc ggaagcgata aaggattctg cagctgagct gtttgaaaac aggcagatcg 1743601 acatccttgt caataatgcc ggcattattc atcgggaaaa agcggaagat tttccagaag 1743661 agaactggca gcacgtactg aatgtcaatc taaacagcct gtttattctg acacagcttg 1743721 ctggcaggca catgctgaaa agaggtcatg gaaagattat taatattgcc tctctcctgt 1743781 cttttcaagg cggcatcctc gttccggctt acaccgcgag caaacacgct gttgccggtt 1743841 tgacaaaatc atttgcaaat gagtgggcag cgtcaggtat tcaggtcaac gcaatcgccc 1743901 caggctatat ttctactgcg aatacaaagc ctattcggga tgacgaaaag cgaaatgagg 1743961 acattttaaa gagaattcct gccggccgct ggggccaagc ggatgatatc ggggggactg 1744021 cagtcttttt ggcatcacgt gcttcagatt atgtaaatgg acatatttta gcagttgatg 1744081 gcggctggct atcccgctga caaataaaaa agctgacgaa cgatcgtcag cttttttcca 1744141 ttacatcatg tgcggttcaa caggcaagac ctttttgacc tcatcaatga tgcgttcatt 1744201 ttctccgcca gcgtaaatgt gaatcgagcc gctgtcttga ttcgagcgaa tcaggcgccc 1744261 gatgccctgc cgtacacgta acaacatata tggcagatca acttcttcga acggatcttt 1744321 tttcgctccg ttgcgcttcg ctgtaaatac aggatcgtgt ggcgggaacg gtaatgacca 1744381 aatggtaaca ttcttcaatg cgtcaccggg aatgtcgagt ccttcccata agtgaactga 1744441 acaaagtact gtttcttctt cctcttggaa tttctctact aagctgctga tttcctcatc 1744501 accttcgaag aaaattggat acggcagctc ccatgccgcc gacagctctt taaactcgtt 1744561 taattcttca aaagaaggga aaagcaccag cgttcttcct ttgtatcgtt tgattgtttc 1744621 aatcgtttca gccgtttttt gttcagcgtc catatctgtt tttgcgtata gattaatact 1744681 catttgctcg tcataatcat aaggggaatc aacagttaat gacaaataat catgaatccc 1744741 aagactgtcg gcaatataat caaacgaacc gccttctgac agcgtagcag aagaaaagat 1744801 ataaggaatt ttcttagaaa acactttttc gccaagtact tctgctaccg ttctcggcat 1744861 cacgacaaag gttgattctg cttccttttt ctccagccag ctgatcgcat ccttttgata 1744921 tagagataat gaatacgcca tttgttcaac atattcttcc actactgaca gttcgtattg 1744981 atcaatcgta tacatttcag actcaaatac aagtgcctca ccgattttat caagtaaacg 1745041 gcaaagctcg tccgccgcct ttttgacacg atggtcattt tttatttcta aacggtgtga 1745101 accggctact tcctttgatt cttcagaaag aacatagaaa aattcgtcgt ttgcgagaag 1745161 cgcatcttca atcaattctg caaactcttc tctgatgtca ttttgcagca atcgttctaa 1745221 aaacaattca agagtagact gcttcactct ataggttagc gctttttgcg cagcaaactc 1745281 taacaagtgc ccctcatcaa atacaactgc actatgatca ggcaagagcg gcagctggcc 1745341 ctctcgtttg cgtgattctt ccgtccacac atgctccata taaaaatcat gggaacaaat 1745401 gattaagtcc gttgacttgc ggtagtaatc tctggaaagt gtcagaccgc atctgtgtct 1745461 catatcacaa gtcagacagt cctgaaacga gtcgtagctt acgtcagacc actcttcatt 1745521 cgatagattt gcgtactgct tacggtcgcc atacggataa aagcgctgca tcgcctggga 1745581 ctcgtggaca aatgacggta acgactcata aagatccagc catttatcat catcagaacg 1745641 ctgcattgtt ttttcaagct tcttcaagca taaatattgc tcatgtgatt ttgacagcct 1745701 tgtatcaatt ttcagatcaa gatgctcagc cagcttagaa atatcgccct cttttttcac 1745761 cagctgttca attaatgttt catccgcaca agcgatgatg gcaggtttgc cgacatacct 1745821 tgcatagctg attgcaaaaa gaagatatac cagcgttttc cccgttccca ctccagcttc 1745881 ggcgaacatg acttttttct ctttaaacgc ccgctccagc tgaaaagcca taaatacttg 1745941 ctcgtcccga agatcaaacc ctttttcggg aaggatatcg taaaacacgt caccaatcca 1746001 attgttcaat tcttcataaa aattctttgt tttcgttaaa gaaaaaggca aacgtgatgt 1746061 tgtcacctag ttccaacccc caactattcg acattcagac caccaataat atcattttcc 1746121 gctgatgaat acaataaaaa acttggcaat gccaagtttt ttgcagttta cttacgattg 1746181 atcacatgcg acgataaaaa aggatggtct gttgaataaa tatgttctac cgctttttct 1746241 aaatcagttt gcgcatgcga aatcacagac ggagacgaat cagtcccgag ctccttcagc 1746301 tcgtttgctg ttgcgtcaag cgccctttga ataagattaa aatgttcgct gttcagcatg 1746361 agatcacctc tgatggaaat aatcatcatt gtatgcgaac ttttcatttt atatacatgc 1746421 tttaccgcat gttatcaccg aaacatgcac aaactacact tgatattccg tctccggatt 1746481 atccgtctta tcaacaatat tctatcaggg agtgatgttg acatgagtta tagaaaccga 1746541 ttagatcagc attctgaact gtttcatcac aattggacgc ggcctaaacg ttcaaagtct 1746601 caagtaaacg gtcacactga aatgtcccaa accaacatta tattgagaag caacgcgaaa 1746661 gctcaccgtt ggtaacgata gaatagggct gaaagatgaa agaagacgca tgcagagcgt 1746721 cttcttttta tgcgttttct gttttcttgc gctgcggtct tacttttgac cagtattgat 1746781 aataatccgt tttaataaac ccgttaaaga gttttcgttt cttcgttgct tttctgccat 1746841 atgcttcctc aaagttttca tttgatgtca gcatatacac agaccaagta tcaagcggct 1746901 cgaacgcctg ccccatttct ttgtacatct gctcaacggc ttttttctcg ccgagacgct 1746961 ctccatatgg cgggttgccg acaattacgc caaattccag atttgtggta aagtctttga 1747021 cctgcatctg tttgaactgg attagatctc ccaatcctgc ttcctctgca ttttcttttg 1747081 cgatttgaac catgcggtgg tctatgtcgc tagcgaaaat tgtaagcggc tgatcataat 1747141 ttgccttttc ttcgacttca agccgcgctt tgttccacag atctttaccg atccattccc 1747201 aatcctctga tacaaaatcg cggttgaatc ccggggcgat gttttggccg attagcgccg 1747261 cttctatcgc gattgttccg gagccgcaga aaggatcaac aaacgggcgg tcaggcgtcc 1747321 aattggttaa ttgcaccaaa gcggcagcaa gtgtttcttt aatcggcgca ccgccctgat 1747381 cgacacggta tcctcgtttg tgaaggcccg tccctgatga gtccagtgta atcaaagcct 1747441 gatctttcaa taaagatatt tccactttat actcagcacc tgtttcttca atccaatcat 1747501 tggctttgcc ggactgcagc ttgagctttt cgacaattgc ttttttgacg atccgctgac 1747561 agtcaggaac gcttgcaagt gttgatttta ccgattttcc gatgacaggg aatttcccgt 1747621 tttcaggtat aaatgagcgc cagttaatcg ctttcgtttt ttcaaacagt tcatcaaatg 1747681 ttttcgcttt aaaagaagca acctgaacct ttatgcggtc ggctgttcta agccaaaggt 1747741 tcgcacggca gatggcaagt gcatcacctt caaaaataac tttcccgtta tcaaccttgc 1747801 attcgtatcc taaatctcgt acttcctttg cgacaacagc ttcaatgccc atcggcgccg 1747861 ttgcaattag tgtatacttc ttcatcgtat caccctgtct tttaaaactt ttctcttttc 1747921 aagataaaag ctctccttat acgggagagc ttgttttcat cattttaaat gtaagtggtc 1747981 taacgttctg taagccatgt tttgttccat cgtactgcaa acggctcatc acctcgtact 1748041 caggcggcaa tcatctatct acagaaagca ttctgtcctt ctctccgttg aattccgtta 1748101 agaaggttcc cctaccaaaa tttgggtttc tcgctcgagg ggtttaccgc gttccactct 1748161 caccatttct agtgagactt cgtcactgtg gcactttcaa ggatactcag ccatatccga 1748221 agacgtaggc ttttttcctg ccgtcagcct ctaaagactg ccctagctta tgacttcgct 1748281 aggcacgaac actacgggca tctcagcacc gtgcgagcat ggactttcct ctacagattc 1748341 aagatctgca gcgattaccc gaacgttaag aacatgaatt attatataac aactgattac 1748401 aatttacaag cgccattttt ttcaagcgtg atcaatcata aagcttgctg ccaaaaacgt 1748461 gtttttctaa gttagacagc cgttttaaaa tatcaaagtt tgttgtgtta gattgcacag 1748521 gctgtttttt gctggcttct tcaagctgtt ttttcagctg cagattttcc tgctgcagtt 1748581 cttcaatttc ttgatggaag gtttcataat ccttaataat catatctaaa aatttgtcaa 1748641 cgtcttcttg cttgtagcct ctaacgcctg ttttaaattc tttttccaaa atttctttcg 1748701 cagaaagctt tactttatca gcaagcatct ttttcacctc gtatcgtgaa tcatcacata 1748761 tattttttca gaaatctgta cggttgtcaa atttctctct cattgttagt agctgtcttc 1748821 ctccactgtc actctcaagt catccattgt aataaagtag atgggatagc catcctgttc 1748881 gcgccttttt tccgctgtcc caagcatata cttaggggag ccttcctttt ccgggtcata 1748941 taaaagcaga agcccgtcgg acttatcaat gaagaactga tttttttgtt tgaattgaag 1749001 cgggctttca taaggacggt gagtcaggct tgcttcatag tctgcctgag ccagaactgc 1749061 ttcatactgt tctttattcg gttctttcca gttcttttcc tgctcgtaaa atggtgtgat 1749121 gacagctacc tttaagtcag ggtattcctc ctgcaaatca tatgcagctt ctgccgccca 1749181 cagctcaact ccaagctggc ccgaaattaa aatccattct aatccttcat ccaaaaaagc 1749241 aatcagccgg tttttaatgg ctttttttat gtaatacagc gccttgtcat cctgcttaaa 1749301 tatccccagt tcaaacggtt tatagcccgt tattgccaat actttcatca tttcacctgc 1749361 tttaaaaaat ggggctcccg tgggccccat ttgttgtgct gcattgttta caccatcaag 1749421 ctgcacgttt tccatactag tagtcgcagc aaggttttcc tgcttgaaaa tgctgatgcg 1749481 tagccgggtc aacatttgag aaagtgtgtg gaaagtagtg aacgtgctga aaatgctggt 1749541 ggtttacgtt tgttgtatgc tgtgggtgaa tgtgcggcac gatagtcttc gaaaacgtat 1749601 ggtgttcaca gcaatgagta ggatggacaa ttggcgccat catatgcggt ctgcagtgat 1749661 gcatgataaa atcccctttc cataaacttt attacaatac taagttatga aaaataaggg 1749721 gtacatgttc tgatgcaaag acctatttta aaagtgtgca attaagctgt ctttaaagtt 1749781 tgaaaacaca aaagcaatca aaaataccac aacaaagaac aagtaaaaaa cacccttata 1749841 cataccaact ctccctttaa aaataactaa cgtcatttta caggattcgc cgctattcta 1749901 caacaaaatc aatgtgaatt cagcaaaaaa aattcatggc gaaacaagtc gtcttttgcg 1749961 ctttcccggg gaatatttaa gaggaatatt tcctctttag ccgggcaatt ctcacatgca 1750021 gtttttcagt ttctttctct gataagcatg ccgcatcgct aagcgattgc tctgctactt 1750081 gcaatgcttt tccgaattct tttttcttat gctcaaaata tttcgcgagc tctattacag 1750141 cagcgtatct gcacttctgg ttttgcgagc gggacagctt ttcccaaagc ggcactgctt 1750201 cttccaagcg gttttgtttt ttgtacagga gcgataaatc cagccgtgca ctgtcctggt 1750261 cctcaaacga tttttctata agcctttcca actgcttgat cgcttggtcc gtttctttat 1750321 gagccataaa ccatttcgcc atagcatagg cttcactgtg ttcttttggc gcatgtgatt 1750381 ctgaaaggat ttttttagac atatggatgt acaatgaaat gagtgataac acatccattt 1750441 cattatgatg caggacacct tttaaaagat ccggctcttg cgccttgata aaatgaaagt 1750501 aaagcattgg cgccaagtag cccggtgtgt cttctagcct gcggatgccg agctcctctt 1750561 tttcaaccgt gccaagagat acacggtcca ttttgtgttt ccacaggcgt ctagctccat 1750621 gcaaaagatc aaagtggcca aactccggaa gcttcggaag tctgtcacgg atcaaggtgt 1750681 gccttgtttt cacctgcggc caatcaaagg ctttgccgtt gtaggtcaca agtgatgtaa 1750741 tgtcaacctc gcttaaaaag ctttggtaca aggcgacttc gttccccggt ttgggcaaaa 1750801 gatgctgttt gactgtcact cggtcttcat atactctcgc atgcccaagc aaaaaaatgg 1750861 tattcccagc tccaccccca agaccggttg tttctgtatc aaagaaaaag aggttgtttt 1750921 tgttataccc ttttgctgac aatgtatgcg acaggccgct ttgattccac agtgtgatca 1750981 cttcctcaag ctcagaaaag ctgtataacc catggcggtg agaaagcgga tattctactt 1751041 ctctgatgag gcaatattca tcttcgaaga tgaaaggctt catgccaaaa gcctcccact 1751101 cttctaaaaa cgggatgtca tcaaagtggt tttcttgttt gcctgcttct attttttgtt 1751161 ctccttcgtc gagcgccatg tgctttttca tccgttggag tttccctttt aatgacatat 1751221 ccggcctccc tccttacgac atttgatcca acagctgcaa aattctttcc tttgctttta 1751281 tcccttctat ttccgtacct atacaagacg gacagccgtc atgacaagga caatgtgtaa 1751341 tcagttgttt cgccgcttca ttaatgtctg aaaaacgttt aaagacttcc tccgccaaac 1751401 cgataccgcc cggataatga tcatataaaa atatggttgg caatccggta tgggctgctt 1751461 taatttgaga aacaacatga acatcatttc gatcacacat gatatacaca gggacaatat 1751521 gctgcagcac attcgagatg ccaagaagca gctgttccag tgtcttttcc ccgatgtctt 1751581 catccgctgt tttgatttcg agccaagctg cacttgtatg cagttcttct tccggcaaat 1751641 gaataggtcc agacccaata ttttcaaaag tggtcatttt tattttttta aaaatggtcg 1751701 gcagggcatt gacagtgacg tctccgtagt gcaatgacgt acggcttttt tctttcgttt 1751761 tatcgatttc taataccttc agctgaactg ccaggtttgc atccgtataa tattcgacat 1751821 cgacttttct gacatacgcc tttttatggt cccaatcgag cttctcaact tgatactgaa 1751881 cgccttcatg caaataaatc gcttcatcat gcaaaagcgt catcgcacta aaacggtcca 1751941 tttcaccgat aatccttaca tttgcaatat ccgactgatc aactataacg acattttcct 1752001 gggaggcgga acgcaaactg atgtttgacg cagggaacga ctcacttgcc caatggtacc 1752061 gttcgccgtt gcggtgaaga acagcctctt cctgaagata ctcaagaata tcactgactt 1752121 ccatggctcc aaattcttca tcagctctaa aaggaagctc ataagccgca cactttaagt 1752181 ggtctactaa aataatcaaa ttctccggat tgattcttgc agattccggc gaacgattaa 1752241 agaaatattc aggatgccgc acaatatatt ggtcaatcgg tgttgaattg gctaccatga 1752301 taatcaaaga ttcaccgtgt cttctgccgg ctcgtcccgc ctgctgccaa gcacttgcaa 1752361 cacttccggg ataccccgtc attacacaca cttgcagctg gccgatatca acaccaagct 1752421 ctaaggcatt cgtactgacc actcctaaaa tgtcgccttc tctcagtcct ctttcgattt 1752481 ctcttcgctc tttcggcaga tagcctcccc gatagcctct gattgatttt gttccaatct 1752541 cttttttcac aagctcctga atatggctta aaataatttc cacccgaact ctgcttctgg 1752601 caaaaacaat ggtctgcact ttgtttttaa ggaactcttt cgccagttca ttcacttctg 1752661 cggttgcgct ccttctaata ttcagcggtt tgttcacaat tggcggattg taaaacacaa 1752721 aatgcttgcg tccgctcggt gcgccgttgt catcgaccag ccgcatcggt ttgcctgtca 1752781 gctgctctcc caattccttt gggttggcaa tcgttgcgga agtacaaata aaaactggat 1752841 cacttccata aaaccggcag atccgcttca gccgccggat cacatttgcc acatggctgc 1752901 cgaacacacc tcgatacgta tgaagctcat cgatgacgat atacttaagg ttttcaaaca 1752961 aactgaccca tttcgtatga tgcggtagaa tggcagaatg cagcatatcg gggtttgtaa 1753021 tgacaatatg acctgctttt ctcacctttt gtctgattgc cggagacgta tccccgtcat 1753081 atgtaaagct tttaatatca atgcccattt catcaataat ttcatttagc tcgctctttt 1753141 ggtcttgtgc cagcgcttta gtcggaaata aatataacgc ccggtttgtt tcatcttggg 1753201 cgatggactg caggactggg aggttgtagc ataacgtttt tcctgatgct gttggcgtta 1753261 cggtaacgat gctctctcct ttttgcacat attgaaaagc ggaatattgg tgagtatata 1753321 gttcatcaat gccccttttc gaaagggccg ctttgattct ctcgtctata ctttcgggca 1753381 taggccttgt ttttgcttcc cgaggctcaa tttcatgcca attcacaacg ttttcatttc 1753441 cttttaaatc agaaatgagt tcagtcagtg atttcttttt cattctttac acctctttgt 1753501 caagtacagt ttaccgaata tttgtttgca tggctaggtg caaattttat acagttgaat 1753561 aaaaaaagca aggcatacgc cctgcttatt tcgcttttat tgtaaagagc tttgattcgc 1753621 ctttacgagc agccttttcg cctgccgata ccattgatcc tacagcctca ccattcatta 1753681 taacgattgg gatgactgtg ctgctcgctt tttcttttat taattccaaa tcacatgtaa 1753741 tcagcgggtc accgaccttc actttatccc cttctttaat gtgggcagta aatccttctc 1753801 cgttcatatt gactgtctcc agcccgacat gaattaacag ctcaattccc gagcgagtcc 1753861 gaatgccaac ggcgtgtttg gtgtggaaaa tctgaatgac ttcaccttca gcgggagaaa 1753921 cgatttcacc gctagaaggt tccaccgcta ttccttctcc catcattttc tgtgaaaaaa 1753981 cagggtccgg tacatctgac aggtccatta ctgtaccgtc tgccggagaa taaataacct 1754041 cttctgtcac cttttcctga attttgccca ttccgaataa ttttttcagc aatgtatttt 1754101 ctcccttctc attcacttca accgttatcc cttcattcac cactatttaa ccacactttc 1754161 aattttgctt caatttataa caacatctgg catagacgca taatctggtt aaaaaaggcg 1754221 gtggcgatat tggaattcca tgatgacaaa aagaacgaac tgcaaaagaa agaagaaatc 1754281 ataacggagg caatcgacac tctttttcaa tcctcagcgt tcggcaacct tataaacgga 1754341 tttcagaacc taatcaactc gagtttaaag gatgtgcaga cgaccataca tgtcagagaa 1754401 agagatactg ggctgtatat cgatattacc attccggcga cgtttcgaga tggcgagatc 1754461 gtcgttgatg ttaaatcgag gtatctccat gtaacactcc aagaaaaaca gaaacaccaa 1754521 aatgaggcta cctttacaag catgacaaga acggttcagc tgccttatga agttcgccaa 1754581 gaagatatgg aaacgtcttg gaacgagcag acaatgacac ttttctttcc aaaaaataag 1754641 catgaatgaa cgattcattc atgcttctat catttaaaaa agctggtaaa tccctttatt 1754701 aaagatccga cctgattcat tgcactcatt acttgacctg tcgtatccat cattttatta 1754761 aaatcaaatt gcccattggc ttttttgaac tgcgacataa tgctttgaaa ttgtgaaggc 1754821 tgctgttgat taggccttgg gataggataa gggttagaaa atacaggcgg ctgcataggc 1754881 ataggctgga tcggagcata aggctgataa taatcctgct gtccataatg ctgctgaggc 1754941 agttgttgct ctaaataacc gggtgcagcc tgctgataat atccttgcat atgctgagga 1755001 taataatagc ccatttgccg aggatagctt cgagagctcc cgttcattgc gattcccccc 1755061 taaacacaac atatttctct tctatatatg tatgaatgac ttctattgtt tgtgtcacaa 1755121 gtgatgatta gcatttgtca aattgtgtcg aaagtttaaa ttttttaaaa acagaaaaaa 1755181 gtcgaatcat tatggtacca tattttcaat acagatgaga ggggatgcac cataatgaac 1755241 gtatcatact taagcaaacg ttttgcagaa atgaagaaat atgaaacaga ctgtatgaat 1755301 aaactgatgg actttgccaa gttcctctat attcaaggac atctcagcat aactgagttt 1755361 cgtaacagta tgaaggttct cgaagcaaat ggagcagaaa gcccggcata tgagatgaat 1755421 taacgtccgg ccccctataa aaacgaaaag aagacagcct tttaccggct gtcttctctt 1755481 gcaatttcat cctttactgc gtgcaatgta taaaggactg actcagtgat gtccttgaat 1755541 cgttttttat gaatatgatg aacataagat tgaaggacca attccaggaa attatccttt 1755601 acggcctcaa tttgctcttt atgcacatat tttggccggc ggacttttat caattcaaga 1755661 gcaccctctg cccagcgagc agccagttca tcattctctt caactgcagg ctttatcgtc 1755721 tcaaaaaaat cataagaatg attactgttt tttccttcct gataccgatc agcgcctttt 1755781 tcagcaactt caatcatttg ctcggtcatt tccagcaaag tttgtgatag caatatcttt 1755841 cacctcaatg cctatcgtac caaatttcac tcacaaattc agccgatgcg gtataccttc 1755901 tcaaacgcat acctgtgttc aggcgattga tacagctcat ttatacaaat atgaagatct 1755961 atgatttctt cttcgagcac acttaggcga tcgttctccg tttcccgcat ctcagcctct 1756021 aatgcattta cagaatgatt caggctttgc tcagctcgcg ttaattcatc ttctatatca 1756081 gaaagcatac ggagaatatc tgtcttgcat acataaccgg acattcgtgt acctcccttt 1756141 ccttgtctct cccggttaac attctttgct ctcaaggctc tttccttcct catgacaaaa 1756201 ctagaagcaa atcgccaaac aaacaggtat tccacgaaaa gctgaagttt tcgacaaaaa 1756261 cacccgcaaa aattgtatga tcctcctcat taatgcaaac gatacttgtg aggaggtgcc 1756321 gtatgaaaac aagaccgaaa aaagccggcc agcaaaaaaa gactgaatca aaggcaatcg 1756381 attctttaga taaaaaatta ggcggcccga accgcccttc tacgtaagaa gcaaggaatt 1756441 tccttgcttc tttatttttt cagccactgc tccaccgcaa aaagcgcatg aagctggcgc 1756501 tttttatgta aataccagtc tgtcaattca atctgcttcg gcaattcctc gcgcctaaag 1756561 aacgttttct ttatctttcc atgaaaccaa tctgttttcg ttccgtctaa tgagtggatt 1756621 aactcagggt agcatgtcct tagcatagga gatgttcttt ttgtaatccc gatcatcttt 1756681 tccatatcaa aacgggaacc tgtgtgcggc actgtgtgca aaaagtgata aaaagaggag 1756741 aacaattctg gcttgaacag caattgagac agctgctttc ccagccttat cctttcctcc 1756801 gcctttgaaa agcgtttcac tgaaatgccg taaaaaaacc catttgagga aggaaaaata 1756861 acggtgttaa aatgaaacca gtcacttaaa taaaaaggaa tcgtgtcaaa aacattcttt 1756921 ttaaacgaag gattttgtat aataggtgtt tggatagtgt tttgttcatt tataatgagg 1756981 gcatacatta gccgctccgt atttcgctca tgccaaaaac gggtccattc ttccgacata 1757041 aattgtgaga cgccaaacac atgcagcaga tgaaacagcg gtttcccaac tctttttgac 1757101 cagtggtata aaagaagctg cggataggca tccgaaaaaa taagccagtt cgctctttca 1757161 taggctaaaa agaaccattt ttgctgtctc tcacggagtc caagctgaaa cagactgcct 1757221 tttaagtcag tcattgacca gccggcatta cgagaaacga aagaagccaa aagcgaccat 1757281 ttgatttccg gatgacggtc gtaaaatgct ttataagcat ttgttcttga aatgttatcc 1757341 gcgtttttca tttttgtctg ccgctcaatc cggctcagaa gctttctgat ggcctgttgt 1757401 tcttgcacgt tcattcactt ccgtcatgat tagtttaata aggaggatga gaaagtgatt 1757461 cggtatccta atggaaaaac atttcagccg aaacattcgg tttcatccca aaacagtcag 1757521 aaaagggccc cgtcttacag taatcgcgga atgaccctcg aagatgactt aaacgaaacg 1757581 aataagtatt atctgacaaa ccaaattgcc gttatacaca aaaagccgac acctgttcaa 1757641 attgtaaatg tccattatcc aaaaagaagt gccgcagtga ttaaagaagc ttactttaaa 1757701 caatcatcga caacagacta caatgggatt tacaaagggc ggtatattga ttttgaggcg 1757761 aaagaaacga aaaacaagac ctctttcccc ctgcagaatt ttcatgacca tcaaatcgag 1757821 catatgaagc aggtaaaggc tcaagacggt atttgttttg ttattatatc cgctttcgac 1757881 caggtttatt ttttggaagc cgataagctg ttttatttct gggacagaaa agaaaaaaac 1757941 ggcagaaaat caattcgaaa agatgagttg gaagaaacag cttatccgat ttctcttgga 1758001 tacgcaccca gaattgatta tattagtatt attgaacagc tttatttttc gccatcatct 1758061 ggtgcgaaag gttgattaac gaaaggttga gatgttatgt cagatcaatt taacagccgt 1758121 gaagctcgac gaaaagcgaa cagcaaatcg agtccttcac cgaaaaaagg caagaaacga 1758181 aaaaagggcg gattgtttaa aaagaccctt ttcactttac tcattctgtt tgttttaggc 1758241 gtagtcggcg gtgctgttac atttgccgtc atggtttctg atgcgccgtc ccttgatgaa 1758301 agcaaattga agacgcctta ttcatcaacg atttatgata aaaatggaaa agagatcgcc 1758361 gaagtcggcg ccgaaaaacg gacctacgtc tcgatagatg aaattcccga tgttgtaaaa 1758421 gaagccttta tcgcgacaga agacgctcgt ttttatgagc accacgggat tgaccctgtc 1758481 cgtatcggcg gtgcattagt tgccaacttt aaagacggct tcggggctga aggcggaagt 1758541 acgatcaccc agcaggtcgt caaaaactcc cttctttcac atcagaagac gttgaaacgg 1758601 aaggtgcagg aagtatggct ttcgattcag ctggagcgca attactctaa agatgaaatt 1758661 ttagaaatgt atttaaaccg gatttatttt tctcctagag catacggaat cggaaaagcg 1758721 gcggaagaat ttttcggcgt tactgattta agcaaattga ctgtcgaaca ggctgcgacg 1758781 cttgcaggaa tgccgcagag cccaacagcg tacaacccgg tcaaaaaccc ggataaagcg 1758841 gaaaaacgac ggaacatcgt actcagtctg atgaaaaagc aaggatttat ttctgattct 1758901 caatataaca aagcgaaaaa agtggcagtg aaagacgaag gcgtcgtgtc acagaaggaa 1758961 tatgaaaaag caagtacaaa caaatacagc gcatttgttg aagaggttat gaaggaaatt 1759021 gatgaaaaat ctgatgtcga tccatctgct gacggattaa agatctatac gacattagat 1759081 acaaaagcac aagataaact agatgaatta atggacggag acaccgtcgg atttactgaa 1759141 ggcatgcagg gcggtgtgac gcttctcgat accaaaaacg gagaagtccg agcgattggt 1759201 gcgggacgca atcagcctgt cggaggcttt aactatgcta ctcaaactaa ggcacagcct 1759261 ggttcgacca taaaaccgat tttggactac ggaccagtta ttgaaaataa gaaatggtcc 1759321 acatacgaac aaattgatga ctcagcttat acgtattcta acggaaaacc gattcgtgat 1759381 tgggaccgca aatatctagg gcctatctca atgcgttacg ctctggccca atcaagaaat 1759441 atacctgctt taaaagcatt ccaggcagtc ggtaaagata ctgctgtaga ctttgcaaat 1759501 ggactcgggc ttggtttaac aaaagataat gtaacagagg cctattctat tggcggtttc 1759561 ggtgggaacg atggtgtttc tcctctgaca atggcaggtg catacagcgc gtttggaaat 1759621 aacggaacgt ataatgaacc gcattttgta aaatctatcg aatttaacga tggcacgaag 1759681 cttgacttaa caccaaaatc aaaatcagcc atgagtgatt atactgcgtt tatgattaca 1759741 gatatgctga aaacagctgt gaagacaggt actggacagc ttgcacaagt acctggtgta 1759801 gaagttgcag gaaaaacagg aacgactaac tttgatgata atgaagtcaa aaggtacaat 1759861 atcgctagcg gtggcgcccg agattcttgg ttcgttggct acacaccgca atatacagct 1759921 gccgtctgga cgggaatggg agaaaacgag gctggaaaga aatcactttc agctgaagag 1759981 caaaaagttg caaagcgcat cttcgcccag ctcatcgccg atgtcgatga cggaagcgga 1760041 tcatttgaga agcctgacag cgtagtggaa gccaccgtag aaaaaggttc taatccggca 1760101 aaactggcag ggccaaatac gccaagcgat aagaagctca cagagtactt tgttaaaggc 1760161 acagctcctt ctactgtttc taaaacatat gagaaagaag aaaaagagga aacagctaaa 1760221 ctgtctggtt taaacgtgaa atacgataaa gacaatcaat ctttaacgtt aagctggaat 1760281 tacgacggag atgcgacctt tgctgttaag caatctgttg acggcggcag ctactcggaa 1760341 attcaaaaca gctctgcaaa agaggcagtt atttcgggtg tgcagccagg atctgtatac 1760401 aaattcgaag taacagccgt cagtgatgat ggcaaaagta cagcttccac atcttatgag 1760461 gtgccaaaag ctgaagacga tgaagataaa aaagaccagc aacaaacgga tgatgaaaaa 1760521 caagatgatg agaagactca ggatgataca caaactgatg attctcaaaa agatgacggt 1760581 cagacggatc aagatcagac agatgattca acaaacgatc aagacaaaaa acaagacaat 1760641 acgaacacca atccgtccga caacaataac caagaccaat caaacgataa tgataacgac 1760701 aacagtaaca accaggatac gtcggatggt gattcgaact ctggtaagaa tgattcaaca 1760761 ggttctgaca cgaataaaaa taaaacagac acatctaata aaacacaaac aaactcatca 1760821 tccattgaaa aaacaaatta aacaaaaaag ccgtcacctt tggggtgatg gcttttttgg 1760881 tacacaataa aaaacctccc gttttaacag gaggttttat cgattcatcg catgatattt 1760941 ataaaaatgc tttttcattt cggtaatcag ctcatcaagc tgaataaagc aatggtattg 1761001 ggtcggctta agaagaataa attccactcg ttcagcccaa ttaatcggct ttgcgggata 1761061 tgatttctcc ctcagttctt gccaatcgag cgatttcacc ggctcacctg ctgtccaatg 1761121 taacgaagcc agcaaacaca caatgccctt taacatttcg ttttggtcac atctcgattt 1761181 tcgtgtttga aagactggga gaagtgatgc tttgatgtca tcccacactt caaataaaag 1761241 cggaacgtat ttcccgctgt cctcccatgg caaatcgcct tgtaattccg tgcagaaatc 1761301 aaaatacacg ggattggtct gcaaggtttt cttcatatcc gaggaactct tctggccaag 1761361 actgcgcaag tattgctcat aggaagccaa cacttctttt gcttgcgtca tcgtttcacc 1761421 agtccttttt tatccctctt ctgcccttct ctgcacaaag aaagcagcgg acactccgca 1761481 cagcgcggag attgggcttt acagtgatat ctgccgaaga aaataagccg gtgatgcgta 1761541 acggaccaat cttctttggg aaccttgcgc atcagcgtct tttcaacttc cagaaccgag 1761601 tccttccacc ggcaaatgcc caatcgtttg ctgactctct ccacatgggt atctacggct 1761661 atggccggca cgccaaacgc aacggatacc actacgtttg cggtctttct cccgacccct 1761721 ggcagtttga caagctcatc gcggtctctc ggcacttctc cgccgtaatc ttcaataatc 1761781 attttactca gcttttgaat atttttcgct ttattacgat ataaaccgat tgatttaata 1761841 tcctgctgaa gctcttccag cggaacagcc aaatagtctt ccggccgttt atatttttgg 1761901 aataatgttt tggtcactct gtttacaagt gcatctgtac attgcgcaga taaagcaaca 1761961 gccaccacta attcaaaagg attggaatga accagttcac actccgcatg aggaaacatg 1762021 tcacctatct tgtctaaaca gaattcaatt tgttttagat ttaacacgat tgtcaccttt 1762081 tcactttatt gttcaagcca attgtaaaaa ggaacctgcc ttttatactc tttttgcggt 1762141 tcattctgct ttgcttgtac acgccggaat ttttggctgt gtatttttgc ctgctccaca 1762201 gttttaagcc catttttctt ccattcaaac aaaatccggt caatgtagcg gaaactgagt 1762261 tttcctgata gtacagcctc ttttaacgcg tgtttgatca gttgtgcgtc atgctgatcc 1762321 tggtcctgcc agatcgccag cgtttcacac tccaaaggcg ataacggtct tgcgaactct 1762381 tcctcaaaaa tggtataaag gcttttttgt tccccttctg cttttctttc ctgtgtttga 1762441 ttctgtgcaa gctgaatata ctcgtacagc ttgccccata aaggctgaag agaatatttc 1762501 tcaaatttga tgccgttttg atcctcgcat tcttcaataa acagaaagcc tttttgaata 1762561 aacatccgca atctgtttgt acattcttca acagaaattg acataccttc ctgcagctga 1762621 ttcggtgtag gaaaatatga tcctttttct aaatgcattt taatttttaa cagcagaata 1762681 agttctgttt cattaagccc aagctgttta taatgcgtga gcagaagatt ggggatggtt 1762741 gatgttccct gctcctgcat atcaataaat tgctgttttt tcatcgtcac acctcttact 1762801 gtaaaggatt gtgattgccc ctttactgta aaaagtctcc cttgcaggag actctttttt 1762861 gtttcatttg aatgtattac ggatacagac ggtttaacag tcttgggaac ggaatcgttt 1762921 cacgaacgtg aggcgctccg ctgatccaag ctactgtccg ctctaatcca aggccgaagc 1762981 cggaatgagg aactgatcca tattttctaa gttcagcata ccatttataa gcgtcagaat 1763041 ccagtccatg ttctttaaga cgcgattcca aaagttccat atcgtgaatc cgttcagacc 1763101 cgccgatgat ttctccatag ccttccggcg caatcaagtc agcgcaaagc acaacgtcct 1763161 cacggtcaga agccggctgc atatagaacg gttttaagga cgtcggatag cgagtgatga 1763221 ataccggttt gtcataatgt tcagcaatcg ctgtttcatg aggcgctccg aaatcatctc 1763281 cccactcgat atcgtcaaag cctttttctt tcagaaattc aatcgcttca tcatacgtaa 1763341 ttcttgggaa cggggctttg atttgctcaa gttttgacgt gtctcttccc aatgtgttta 1763401 gttcaatttt gcaattttta agaactgatt gcacgatgaa agaaacgtaa ttttcctgta 1763461 cttgaaggtt ttcttcaaat tctacaaacg ccatttccgg ttcgatcatc cagaattcga 1763521 ttaagtgacg ctttgtttta gacttttccg ctctgaatgt cggtccgaaa gagaatactt 1763581 ttcctaaagc cattgccgca gcttccatgt agagctgtcc gctttgagac agatatgcat 1763641 cttcatcaaa gtactttgtc gcaaagagtt ctgttgttcc ttcaggtgcg cttccagtca 1763701 aaatcggcgg atccactttt acgaagcctt cgttattaaa gaattcgtaa gtcgcgcgaa 1763761 tgatttcatt acggattttc atgatcgcat gctggcgctt tgaacgcagc cataaatgtc 1763821 tgtgatccat caaaaattcc gttccgtgtt cttttggtgt aattggataa tcggtcgctt 1763881 cgtgaatgac ttcaatatct gtcacagcaa gttcatatcc aagcggagaa cgctcgtcct 1763941 ctttgacaat cccttttata tagagcgacg tttcctgcgt cactgattta gctgtttgga 1764001 aaatgctttc ttccacttcc gcttttacta cgacaccctg aataaaaccg gtaccgtccc 1764061 gaagctgtaa aaacgcaatt ttcccgcttg aacgcttatt agcgacccaa gctccgatcg 1764121 ttacttcctc acctacgtgc ttgtacactt ggttgattgt tgttttcaac atatttccct 1764181 ccaaaacaag aaagacattc ggaagctcat tgccccgcga actcttttat catcacttta 1764241 ttatacccgc tcttaactaa ccgggtcaat gcagataaaa agcggctttt ctgtcagccg 1764301 ctttttgatc tgttagctat gtttttctac aaaacgcttg attctttcaa tggcttcttc 1764361 aagaagatct aacgatgttg cataagaaag acggacattc tcaggagagc caaatccgga 1764421 tcctggaaca atcgcaactt tttcctcctc gagaagcgct ttaacaaatt catctacatc 1764481 tttgaaaccg caagattgag ctgcctcttt tgcatttggg aacaagtaaa aagcaccttc 1764541 cggcttcacg cagctgaacc ctgggatttc tatgagcttt gcatagatcg tatttaatct 1764601 atgttcaaat gcttctctca tttcttccaa tggctcagaa ggcccgttat aagcagcaat 1764661 cgctccgtat tgtgcgattg atgtcgggtt tgacgtgctg tggcttgcaa ggttcgtcat 1764721 cgctttaata atgtcttcag agcctgccgc ataaccgatt ctccagcctg tcatgctgtg 1764781 ggacttcgat acgccgttta taatgaccgt ttgctctttc agtctgtctg acagctgtgc 1764841 aatggaaaca tgtttctttc cgccgtatgt aagtttttca taaatttcat ctgacacaat 1764901 caagatatca tgttcaaggc acacttcacc gagcgcagat agttcttctt ccgtatacat 1764961 gacaccagtc gggttgcttg gagagttaat aacgattgct tttgtttttt ccgtaattgc 1765021 atttttcagc tgctcaggcg aaattttgaa gtgattttcc tcaagccctt ctacataaac 1765081 aggctttccg ccagcgagtt tcacctgctc cgggtagctt acccagtaag gcgttggaat 1765141 aataacttca tcttcttcat ccaaaatcac ttggaaaagg gtatacagag catgtttggc 1765201 accagtgcag acaataattt gagacggttt gtattcaata ttctggtcgc gtttaaattt 1765261 ctctgcaatg ctgtttttca gttcagccaa accaccggaa ggcgtgtatt tcgtatggcc 1765321 ctcgttcatc gaacgcacag cggcatcaat aatatgctgc ggtgtattga agtcaggctc 1765381 gcctgctcct aagccgatga catcatggcc tgcggctttc agttctttcg ctttcgctgt 1765441 gattgccagt gtggttgatg gtgttaatgc ggatactctt tttgccagtt tcaacttgaa 1765501 ctccccctaa ttcgtcttaa ggcgtgatat ttttgagaat ctttccagtt gtaaagtcca 1765561 cataacttaa actgtattgc ccttctttgt ctaagtacgt cacttcccaa agcaggacgt 1765621 ttccttctct tgccagatga acctcttttt gctttgaaac cagcccttca tcctttatga 1765681 ttttcgccgc tttgtcttca gagattccct ctttcgcttc ttttgagaga atttttgctt 1765741 ttttatcagc aggaacccag acatataatg cagtgccttt tttatccgtt ccctttacaa 1765801 cataatattt ttcttttccg acaaatgttt cgacttgatc aacatgggcg agatcggttt 1765861 cttttttagc ttcagcagct gctgcttcgt gcccctcttc cttttgtgcc atggctgatt 1765921 tataaatgct tgccgagaca agaagtactg ctaaaaaaat aataccaaaa atgacggtaa 1765981 atattaatgc tttttttctc atcttctcac ctacgtacga taaatggtaa aaacggcttg 1766041 gtttttgttt tcttcatcca gcgcaaggcc gaacatcaga ttgtctcttt tcagtgtacg 1766101 attcaatgtg tccacaattt tatacagatc atcagaatgc tctacattaa ttgttgaaag 1766161 aatttcgatt ttactttcca ttttttcatc ctccagtttg aacaaatatt gttagtcata 1766221 ctccatttca ggacacgcca tactagtatc acagagcggg aaatccgctt ttaaataaaa 1766281 caccatccta ctcccacacc gcaaaagccg ctttatgcgg cttttattct ttttcccctg 1766341 caacataagc ttcaagctcg ctgtcagtca tttcggatac tgaggttgtc ggcaaggcat 1766401 caagaaacag ccggccgtaa ccagcggttt taatccgtct gtccaatata ataatcgttc 1766461 ccttgtctcc cgcagaacgc agcaagcgtc cgattccttg cctgaaggtc agcacagctt 1766521 ccggtaatga cactgtttga aacggattct ttcctttttt gcgggcaagc tcacattttg 1766581 cagcatgaag cgggtgatca ggggaccgga atgggagcct cacgatcatt actgtcgtca 1766641 gctcatcacc agggaaatca acgccttccc aaaaatgatt tgttccgagc aggatcgcct 1766701 gattggatgt tttaaaagtc ttcatcagtt tgccgggact tccgcctgta atcccttgtg 1766761 ccaagagctg aatgccggaa gcactcatgt tatgcttaag ctcctggtga acctttttca 1766821 gcatatcatg ggatgtaaac agcacaagga ttttaggctg tttttccttt gccatcagtt 1766881 cgatataacg ggctgtatcc tgtataaatt caggttgccc tgtatcctga attgatttca 1766941 tttcttttgg aatcatcacc tgcatacgct catcgtaaga aaagggtgac tcaattctca 1767001 ttgtccgcgg gaaaaagtca ctcagtccca gtcgttcaat cataaattga aaagaacctt 1767061 cgactgtaag agttgcagat gtcagcacca cactattttt gcgcgcgaaa aactgatcag 1767121 ccagaagttc accaggttca agaggctgtg cgtaaatggc cactgcattt ttcgcaccct 1767181 ttgcatctat ttcaatccaa accgcttcat cgtcatcaga gccaaagaag agcttctgca 1767241 acgtctgaca gtaatgctgc aagcctttca tgcttctttg gtattcatcg gctaaaaaga 1767301 cggttttgct cttcatgccc ttcaaatgtt tttccataag ggatgactgc gcctcaaaaa 1767361 gctgctgcaa atgtgtcagc atggaacaaa gcctctccgc accatctgtt aagatcgacc 1767421 agcttttatc ctggctttct ttgttcacct taaacactag acggtttaag tcttctttag 1767481 gttttcttcg tttgacaaaa gaatgtacag agctaaagaa agcatcactt tctgcttgaa 1767541 cgtgctgaag ccactcttcc aattcgaaaa atgaatcaac cggcaggctg tttcgctgga 1767601 atagctgtct catctttttt agaagtccct gctccttcag agtgccgatt ctgctcaatt 1767661 tcgtatgcaa ttctatgtac gtggctcttt tccctaaatg ttcgcttgcc gcacgttcaa 1767721 aatggtgtgc ttcatcaata ataaatgtgc cgctttcggg aagccttttt ttatggctgc 1767781 cttcatcggt cagcaaaaga gaatgattgg tgatcaccaa atcggaacgc atagcaatct 1767841 gtttggcccg ctcgtaaaaa ccgatcacat gctcactgcg acttctttta taggagtcat 1767901 cgtcataagc caatctgtcc cacagcaatt ttccgcctga aggcaaattc agttccgcta 1767961 catctcctgt atttgtctct gtcagccaaa caagaagctg tgcctttgtc agtacggcat 1768021 cataattatc atcttcttca tgaagcacct gctcaaattt atacaggcat aaataatgcg 1768081 attgcccttt taaaatcgcc gctgttaccg gaaatggaaa cagatcttgg acaatcggca 1768141 aatcctttgt gagaatctgc tgctgtaaaa gcgtcgaata cgtgctgatt atgaccggct 1768201 tttttgattt cttggcaaaa agcgcagccg gaataagata gccaatcgtt tttccgatgc 1768261 ctggaggagc ttcaatcagc gcatgctcac gattggcaaa cgcatcagcc acctctctca 1768321 tcatcatcat ttggccgtct cttttttcat acccaggcat taactctgac agcgcttttt 1768381 catttcccgc ttcccagctt tcgatctcaa atgagaagtt ctcgtcctca tttatacgaa 1768441 catcgatagc ttcaggttct ctgacagaaa acgaagaaaa gcgcgtatag cccggtatct 1768501 cggtatgtct gttttcatta atgaacatat ccaacaaatg cgtcagatca ctgatgaaat 1768561 gctgcgaaag ccttcttaac tgctttaatg tcggataagg aagctgccgc agcttttcaa 1768621 ggatttccaa aaaaataagc cctgtcactt cagcatcgct gtcagcccgg tgcggctgat 1768681 catgccgcag ctgaagctcc tcgcttaatt ccgtcagctt atacccttca aatcccggaa 1768741 aaacaatgcg tgagagctcg acagtatcaa gcacttcaca atctgggagc tgaaagcccg 1768801 ccttatgtag ctcatacttg acaaatccaa ggtcaaaatg gatattgtgg gcgacaaaat 1768861 aagcgccgtc aagcaattgg aatacttctt cagcaactgc ttcaaatggc tgttcattct 1768921 cgaccatttg attagagatt ccagtaagct gctcaataaa agcagggatt gatttatttg 1768981 gattaatgta ttttgaaaac cgctcagtaa tttgtccatt ttcgattaca accgctgcga 1769041 tttgtatgat tttatcgcct ttcttcggcg aattccctgt tgtctctaca tctataacaa 1769101 cgaaccgttg cttattcatt aaaatggaca cctcaattct tgcatacgac aaaagtgtaa 1769161 cacgttttgt acggaaatgg agcggcaaaa ccgttttact ctcaaaatct taaaagaaaa 1769221 cccccgataa agggggcttt tcttctacaa aattgtacgg gctggttcgt tccccagcat 1769281 ttgttcaatt ttgttttgat cattcagaac agccactttc ggctcatggc ttgccgcttc 1769341 ttgatcagac atcattttgt aggaaataat aatgacctta tctccttcct gcacaaggcg 1769401 tgcggctgca ccgtttaagc atatgacgcc gcttccccgt ttaccaggaa taatatacgt 1769461 ttcaagacgt gctccattat tattattcac aatttgtact ttttcattag gaagcattcc 1769521 cacagcatca atgagatctt catcaattgt aatgcttccc acatagttca ggtttgcttc 1769581 cgtaacagtt gccctgtgaa gtttgccgct catcattgtt cgatacatat tatattctct 1769641 ccatttctcg aatatcaata atgatattat ctattaaacg cgcttttgaa aaagcaactg 1769701 caacagcgag aatcatcttt ccagcaattt cattcacagg ctcgagttcc ggataggaat 1769761 aaagctctac atagtctatg gttccgctag tcgtttcaat gatatctttt gcagctttta 1769821 tcaccgcttc aggatctctt tcaccggctt ggacaagttc cgcacttgtt tgaagggccc 1769881 gatacagctt aggcgcttct tttctttcct cagctgttaa gtatacattg cgagagcttt 1769941 tggctaagcc gtcttcctct ctgaccgtat cgacaggaac caattcaata tccatgaaga 1770001 agtcgctgat taacccatca acaacagcta cctgctgcgc atcttttaaa ccgaaatagg 1770061 cacgagtcgg cttgactaga ttgaaaagct tcgtcagtac gatcgcgacc ccgtcaaaat 1770121 gtccttctct tgagcgcccg cataacacgt ctgtgcgtct ttctacatga atcgtgacat 1770181 tcttttcacc gggatacata tcatgagcat ctggcgtaaa aagaatatcg actccggcgt 1770241 tttctgcaag agctgcatcc cgctcaatat cgcgcggata tgcttcaaaa tcttcattag 1770301 ggccgaattg tgcaggattc acaaaaatac tcataataac ggcgtcgttt tcttgtcttg 1770361 ctttgtctgc taaggttaaa tgcccctcat gcagaaaccc catcgtcgga acaaatccga 1770421 ttgacttgcc ctctgaatgg tattgtttta tggcttcttt cagctgtgaa atatcagtaa 1770481 tctgtctcat cttattttcc cccgtacaag ccgtcaagca ctgtctggtt catttgaaag 1770541 gaatgctttt gttcagggaa agcacgatgt cttacatcct gaacatatcc gctgattgct 1770601 gtttcgatgg tttcatcaat gcgcgtatat tgctttacaa atttaggtgt tctctcaaca 1770661 ccgtggccga taatatcatg ataaacgaga acttgtccgt ccgctttcac accagccccg 1770721 attccaatga ccggtatgct tagcgtctcg gcaattttgg ctgtgagttc tgccggcaca 1770781 cattccagca caagcatcat agctcctgct tcttcgcatt ttatactgtc ttctattaat 1770841 tttttggcgc tttgttcgtc tttgccctgt actttatagc cgcccagtac gccgactgac 1770901 tgcggtgtca aacctaagtg actgactact ggaatgcctc caagcgtcaa tgcgcgaatg 1770961 gattcaaaca cgccttctcc gccctcaagc ttcagtgcgt cagctccgct ttcctgaacg 1771021 atagccgctg catttttcag cgtatcttcc ttagacaggt gataagacat aaacggcata 1771081 tctgtcacaa taaaggtatt cggcgcaccc cttttaacgg cttttgtatg atggatcatg 1771141 tccgcaactg tcacaccgac agttgaatca aggccgagga cgaccattcc aagtgaatca 1771201 ccgactaaaa tcatgtcaac tcccgcttgt tcagcaagtt tagctgccgg ataatcataa 1771261 gcggtcagca tgacaatcgg ttcttcagac tccttcattt ttagaaaatc cagttttgtt 1771321 ttcatgtttt ctcctcctca tgtttagagg agatgatctg ccgttttctt ctgcaagcca 1771381 aaaaaccttc cgttacaacg agaaggattc ttcactttct aaagttcggc gagtttcatc 1771441 cctctgtccc agtccttttt tggatcaagg cagactgctg caatgtctat ctattttaat 1771501 aataggtgca gttcgcaggc gatactgccc aatggaagta taccaaaatc aacgggcttg 1771561 taccaacaca ttagcccaat tcgatatcgg cagaatagat ttttttaatg ccttcgttcg 1771621 tttctaaaag cagaacgcct tcatcatcta tacctaacgc cttaccgtaa aaggttccgt 1771681 ttaacgttct ggctctcata ttagtgccaa taccgagcgc atagctttcc cataaaagct 1771741 taatcggcgt aaatccgtgc gtcatataat cccggtaccg tttctcaaag catagtaaaa 1771801 tatgctggat gacgccggcc cgatcaattt tttccccagc agcttggctg aggcttgtcg 1771861 cgatgtcctt caattcatct ggaaaatcat taggctgctg gttaacgtta atgccgatcc 1771921 caatgatcac tgaacgtacg cggtcttctt cagcctgcat ttccgttagg ataccgactg 1771981 ttttttttcc gttaatcaaa atatcatttg gccatttaat atccgtttgg atgcctgctg 1772041 cctcttctat tccctgcaca acagctactg cagcaagcag agtcagctgc ggtgtttttt 1772101 ggagcggaat gtcaggccgc aaaatcaggc tcatccaaac accgtttcct tcttgagaat 1772161 gccataccct agacattcgg ccccttccgg ctgtttgttt gtcagccacc acaagggtgc 1772221 cttccggtgc gttattattc gcgagctcat gagccgtttt ttgcgtgctt gaaagaacgt 1772281 catggtaaat aagatgctgg cccatcactt ccgtttttaa tccaaaacga atttcgcttt 1772341 cactgagttt tccgggtttt ttgatgagcc gatatccttt tcttctaacg gcttctactt 1772401 cataaccctc tttccgaagc tcttcaatat gcttccacac agcagttctt gaacagccga 1772461 gagcatcact gattttttgg ccggaaataa attcattgcc ggcctgagaa aataattcaa 1772521 taaggtcttt tcttaatgtt gaccgcatgt cttcagccac tcctctatgt gtttcttttg 1772581 attggagagc ttccctgtca caacagcctg ctcgatccac tgtaattctt ctgacaccca 1772641 ttttccggcc ggccggtttc gaagcgcaag caagtcctta cccgtgatat caagatcctt 1772701 aaggcttttg atcggcaggt tttgataagc gtactgaatg tccttcagtt tcttttcatc 1772761 cagtttttcg ttttgccgaa gctgcgatat tttggccgct gagagcagtg cttttttccc 1772821 agctctgtac attgtcattg cgtcaaggct ctggccaaac gtatcggcaa tgtgaatggc 1772881 ttccttgatc acttttcccg ggagcttcca ggctttcagg aaaaggggcg cgtctttcaa 1772941 aactatgcca aggttaatta aaagagcagc ccaaagctcc tcacgggatg ttaaagagaa 1773001 gaatggaaac tcactcgttg aaatcaggtt ttctcgttta tgataaaaac caggaagctc 1773061 ttcatacaat ctcgtttgaa tgagtgtttg aagcgcctgg cgagaagctc ttccctgcag 1773121 caatttctca aactctatag tttttcgttc gactgaaaca tgggagagga gtgatttttc 1773181 tttcgcaatg gcttcttctg tttccggtga aagcgtaaag ccaagctggc tcataaagcg 1773241 tacggctctc agcatacgaa gcgcatcctc ttgaaatcta tcctcaggct ttccaacggt 1773301 tcgaatcact ttctgatcaa tatctttctt gccgccaaaa taatcaagca ccttcccgtc 1773361 cgctgtcatg gccatcgcat tgatcgttaa atctctgcgt tttagatcct cttctaatga 1773421 tgagataaat tgcacttctg acggtcttct gaaatcaaca taatcagatt cagtccggaa 1773481 tgtcgtgact tcataggttt catcctccca gagcacaata atggtcccgt gctctttgcc 1773541 tacatcaaca gtccgctgaa acagccgttc tacttgatca ggtgccgcat ctgtcgcgat 1773601 atcgacatct ccgatcgttc gtttcatata gctgtcacga actgcgcccc cgacaaaata 1773661 agcctgatgg cccgcttcga ttaagatgcg gagcacggga agtgctttga taaaaacttt 1773721 ttccatgtga tcactccggt tctgctaaat cggcataaat ctgttcatac tggctgacaa 1773781 tttttttaga agaaaattca ttttcaagca tctctattgc cgcctttgta aaacgattgc 1773841 ttagctgttc atcttctaaa atgctcatcg cgcgggctgt tgcggccgta acatcaccga 1773901 catccaccaa aaatccgctc acattgtttt ttataacctc agggataccg ccaatgtttg 1773961 ttccaataca aggcactccg caagccatcg cttcaagcag gacaaggcca aagctttctt 1774021 tttcagatag cagcagcttc aaatcgctaa tagaataaag atcttcaaca cggtcttgat 1774081 ttccaagcat taagacttgg tcttccaagc catattttct gataagctcg caggctgtcg 1774141 atttctccgg accgtctccg actaaaagca gcttcgcttt cgttttgcca gcgatattgc 1774201 ggaacacacg gatgacatcc tgcacgcgtt taacttttct gaagttggac acatggatga 1774261 cgactttttc atctggtaaa attccatgtt tctctttaat tgccgctgtg tttttcttca 1774321 gatacacgcg ctcgtctata aagttataaa tcgtttcaat ttttttctcc ggtttaatta 1774381 aatcgtatgt ttcagccgca agcgctgagg agacggccgt caccctgtct gatgactcaa 1774441 tagcaaaacg gatcagatct tttagagacg gatcataacc taacaccgtg atatccgtgc 1774501 catgcaaagt ggtaacaatg ccgatattgc gtttcagcat ttgttttgca agataggcgc 1774561 aaacggcatg cgggagagca tagtgagcat ggataatgtc taaattctcc cgttccgcca 1774621 cctcagcgat tttgcttgcc aatgtcaaat catacggagg atacttaaaa acagcatatt 1774681 gattaacctc aacttcatga aaatgaatat tgggatgata tgtattcagt ctaaacggaa 1774741 tgcttgatgt gatgaaatgg atttcatgtc ccttttcagc aagctgcttc cccagttctg 1774801 tcgcaatgat acctgagcct ccaacgctcg gatagcatgt gattcctatt tttagttttc 1774861 tcattgttcg cccccaagca catcatgatc aagcatcagc atccgtttgg aaaagaaacc 1774921 ttcggcatac tccacgcccg cttctttacc gtaaagcttt tctctcgctt caacgatttc 1774981 aatataccca ttcgtcagag gagtagaaac ggaatccttt gacgggataa actggctttt 1775041 gtaggcgttg aggctttgtt tctttgcctc tattgtatcc gagatatcaa taacaaaatc 1775101 cggctgatga aaaccattta tcatataata gtaaaccttg ctgactttat gcgccggaag 1775161 gcttttttcg tctttatatt tatggattcc ggcggaaaag atcgcttctt ccaccagtgc 1775221 agccgcattg ccgtgatccg gatggcgatc ctttttatac ggcataaaaa ccgcttttgg 1775281 ccgacagatt ctgatgacag tgacaattga ccgaattgcc tgatcactca ttattaggcc 1775341 gcggtctgga agcgttagct gaattctttt atctgcgcct aatatgcggg ctgcttcagc 1775401 tgcttcttct ttacgcaaac tgaccgtacc gttagaagag agttccgctt ctgtcaaatc 1775461 gcatatcatt actttttttt cctgtttgac aaacttcgct attgtgccgc ccattccgat 1775521 ctcgacatca tcactgtggg cgccaaaagc aagaacgtca gcattataca ttcggctctt 1775581 ctccccgaag aaggtcacgg aattcgaaaa caccttcatc aagtgtgcgc acaagaattt 1775641 ccgcagtacc catatttgtg gcgagcggaa tggaatacac atcacataaa cggattaatg 1775701 ccgagacatc cggttcatgc ggctgcgcgg tcagcgggtc gcgcaaaaaa atgacaagat 1775761 cgagtgcatt ggcagcgatc agtgcaccga tttgctggtc tccccctaaa gggccggatt 1775821 gaaaacgttc aatttgaaga cctgtcgcct catgaatttt caaccctgtg gttccggttg 1775881 cgtatagatc atgattcttt aaaatatccc gataggcagt cgtaaattga accatatcct 1775941 gttttttctt gtcatgcgcg atcaaagcaa ttttcattgt ttatcccccc gtctaatcaa 1776001 tgatattttc taaaccatac acaagctgat caatcttcat gacttgttcg actgacagtt 1776061 taacgcctga catgaaagaa gcacggttat aagaatcatg gcgtatctga agcgtttggc 1776121 catccatgcc gaacatgacc tcctgatgcg cgatcagtcc cggaagacgg acgctgtgca 1776181 agcgaatacc gttttgctcc gctcctcttg ctcctgggag aatttctttt tcatccggat 1776241 gtccttgctg cttttcttta cggacttctg aaatcatttc cgctgtttta agcgcagttc 1776301 cgcttggtgc gtcaagcttc tggtcatgat gaagctcaat aatctcaaca tcctcaaaat 1776361 agttggcagc catttttgaa aatttcatca tcagtatcgc accgagcgca aaatttggcg 1776421 cgatgatggc tccgatccct ttttcttctg ttaaagatgt gagctctttt aaatcagctt 1776481 ctgagaaacc ggttgttccg acaactggac ggactccgtg ctctaatgca atttttgtat 1776541 gtacttttcc gatttcgggc gttgttaaat caatcaagac atccggttgt gtttctgtaa 1776601 aacaggcatg gatatctgtg taaatgaaag catctgactc aacaggcatc acatcagata 1776661 atttttgctg atcgtatgta tggtctatgg cccctacaag gtcaaaatgt ggtgttcgtt 1776721 ctgccaattt aacagcttcc tgccccattc ttccacgcgg tcccgcaatg actaatttaa 1776781 ttgtttcgtt tgacatcttg atctcctcta ctttccttct tcttttctgg tccagcgatc 1776841 tttatctctt gtattaaatt tatgcatgac tcggtcgtga gcttcctcta aagagatatc 1776901 aagagagttg gctaaacaaa ccaatacaaa tagcacatcg cctatttcct cttccatgct 1776961 tttatcatct tcagtcgctt tttttggttt ttctccataa cggtgattca cttctctggc 1777021 aagctcgccc agttcttcag tcagcctcgc catcatggcc agcgggctaa aatatccttc 1777081 tttaaattgg cctatgtaac ggtctacttc agcctgtatg tctttcattg ttttatcact 1777141 cactgaacga aacctcctat catcctctta catgttagct aattcagata cgtttgacaa 1777201 atgtttaagc acgtttgctg ttttcttttt catccactat aatataaacg ctatctaatg 1777261 gaaggaaaag gggttttgtg tgatgcttgg agaaattaga ttaaaaaaca tattttttat 1777321 tttaatcgga gcggcaattt tttcatttgg cttggttcat ttcaatatgc agaacaatct 1777381 ggctgagggc ggttttacag gtattacact tttgctttat gcccttttcc acatcagccc 1777441 ctctatatcg aacctggtgt tgaacattcc gatttttttt attggctggc gtttgctcgg 1777501 caggacaatg tttgtttata cccttgtcgg cactgtagcc ttgtctttgt tcctcagcat 1777561 ctttcagcga tatgaaatcc atatgcccct tcagcacgac ttagcgctcg ccgctttatt 1777621 tgccggcgta ttcatcggag ccggactggg tattattttt aagttcggcg gtacgacagg 1777681 cggtgttgat atcatcgcac gtttagtgaa taagtatttt gggattccga tgggcagaac 1777741 gatgtttgct ttcgatgcct gcgtcatcat tttgtctttg cttacttatc tctcctataa 1777801 agaagcgatg tatacgctgg tagctgtatt tgtagcggca agattaatcg attttattca 1777861 ggaaggcgga tacgctgcta aaggcgctac gatcatctct tcgaaaaacg acctgattca 1777921 gaaaaagatt cttgaagaaa tggaacgggg cgtcaccatt ttgaaaggac aaggttccta 1777981 cacaaaagag gatatagatg tactttattg tgtggtgccg aaaaatgaat tggtgatgct 1778041 gaaaagcgtg attaactcca ttgatcccca tgcctttgta gcggtaagcg atgttcacga 1778101 tgtgctcgga gaaggattta cgcttgatga aaataaaaat ccgcttccgc gctgacatgt 1778161 aatagaaaaa aggcggctga ccgccgcccc tcatccttat ttagggtagt cccttttttt 1778221 cagcttgttt ttttccgcct tgtactttct gtaaccgaca taggtaagag cagtaatgat 1778281 gatactgccg gttgtaatga tcacccagag taaagacgga tcggcatcat cctcctccac 1778341 cctgtcaaac acatttttca ggtcatgctg aagaagggaa agccgttcaa gcttcgtgct 1778401 ctctgtcatt tgctgaaatt cctcttgctc aataacatct atatgttttc cgactgtttc 1778461 aagctgatcc tctgatacat cgattgtaag actggggtaa atcaagtcat ataaactgat 1778521 aaattcattc catttttcat gaaagcttgt gcttccattc ttttggacat ctcgcttcag 1778581 ttcagtaaaa gcttccataa tcggtttttc cagtgagccc caaagcgggt cagaccgatt 1778641 gtcaaccgca tccatcagca ttctgaactg cgcggctgct ctgagttttt gtgtgtctga 1778701 tgtatcagct tgctttaaac tccgaaccat atcattatag cccaatgtga tttgacgaat 1778761 ttgggctccc gttagcatgg ggtcttgctg ttttttctca gcggatttta atgttttttc 1778821 aaaatactcc aagacttgaa gcgcctcttc atatttcgcc tgtcgggtca tttgaaagac 1778881 tgtatcggat aaatcattca attcctcgag gcttccccgc tctgcagcct tggcatttcc 1778941 attataaaaa ataagtgcaa tcaacaaaca gatcgtcagc tttcgtttca tgcaggtccc 1779001 tcccactctc tctccttaca gaatatgaag aaagggacaa ggatagacca acattgtctt 1779061 tacatcagct caagcttcgt ttgctttttt gagaccacaa gaaagtaagc aagcgcgatt 1779121 gaaaagatac ttagccaaaa tgttccgtat cctatttcag tcatataatc agaaagcata 1779181 gagtattgcg gcatcatatc aaacaagtag tcaatgacat cgttatgcag tgtccagact 1779241 gcagcaattg caagatgcca aaatgaaaaa cgaaaatacg gactgtataa tacgccttga 1779301 actgccattg caaaatgcga agcaattagc atgtagccct cccacggcaa gtcaccagtt 1779361 actgcaagca caagaaaatt catagccacc gcccataggc catactttac gagggtaact 1779421 agcgcaagcg cctctaaaag cggagcattc cgtttcatga gaaaggcaag cagcacaaac 1779481 agaaagaaaa acgttgctgt cggactgtcc ggaacaaaaa tcaggaaacg ggccggtgtc 1779541 tccaaaagct gcggcaagta ccaatagtag ccgtaaaccg ttcccagaaa attaatggct 1779601 aagacaagaa taagcatcgg ccgctgccct aatacatatt gaaaccattt cacatcgaat 1779661 caactctcag tctgtaaaaa taatatgtcc atataaaaaa gctgacgccg ggtcagcttt 1779721 tgataataaa agtatatcct tccatttgac aattcacaat acgttatttt gcggttgttt 1779781 cagaaataaa ttttgcaagt tcttcgagct gcttatcatt tcctttgaac acacccgccg 1779841 gcattttgcc tttcccttct acagcgattt ttttgatttc atccggtttc agcccgctgt 1779901 caaccaatga aggcccggcc gctcctccct gaaggttatc cccatggcaa gaaatacagc 1779961 cctgttcctt aaaaacctta tatccttctg cattggtgtc aatgtcggct tcttttgtaa 1780021 ttttcccctg ttcttctgcc ttggcccagt catgagtagc aactgactgc cacgtcaaaa 1780081 atacagcagc ggaaatggcc agaagcatca taccgacagc gaccggacgc ttccacggcc 1780141 ttctttctgt ccctctgtct aggaatggag ccaaaagcag ggccccaaaa gcgagacctg 1780201 gcataatcat ggcgccgacc actgtaaagc ttccggcggc gtattcatac ttcaacagct 1780261 ggtataagaa aagaaaatac caatccggca gcggaatata accagtatca gtcgggtccg 1780321 ccatccgctc taaaggcggc tgatgcacaa tcgtcaaaac gagaaaaccg atgagaaaga 1780381 cagctccaac catccattcc tttaacaaga aatttggcca gaaagcctct gttttacccg 1780441 gatactccga ataatccttc ggtatattcg gctttttttc agccggtatc cttgagtcgc 1780501 ctacaaattt catccctttg ccccggtgca tgtcatcccc tcccttttat tcgcagatca 1780561 agagtttaaa gcggtcctga aatcccctgc ttccggatca taataaaatg tgcagccatc 1780621 agcccgaaca atgcggcagg aagaaaaaat acatggatcg caaaaaacct agtcagcgtt 1780681 tgggcgccta caatatccgg atgccctgca aggagcgttt taacttgcgt tccgatcaaa 1780741 ggcgtggctt cggcgatctg cagtccgact tttgttgcaa acagagcctt catatcccaa 1780801 ggaagcaagt agcctgtaaa gccaagaccg agcataacaa aaaagatcag cacaccgaca 1780861 atccagttca gctcgcgcgg ttttttatac gcgccttgga aaaagaccct cagcgtatgt 1780921 aaaaacatca tcacaatgac caggctcgca ccccagtggt gcatccccct gacaatctgg 1780981 ccgaatgcca cttcattttg caaataatat accgattccc aggcattttt gatatcaggc 1781041 acataataca tcgttaaaaa cattccagat aatacttgga taacggttac aaaaaacgtc 1781101 agtcccccaa agcaatacac aaacgcagag aaatgatggg cgggattcac atgttccggt 1781161 acttcgtgat cggcaatatc cctccacatc ggtgtaatat caagccgctc gtctacccag 1781221 tcataaattt tgttcagcat gtcacccttc ccccttaggc tttgcttttc caagatacag 1781281 gaagccgtct tttacttctt gctcataatg atcaagaggc gcaagcggcg gcgtgccagg 1781341 gacattggtg ccgtcctttt catagagtcc gtaatggcat ggacaaaaga atttattcgg 1781401 gtttttagga tcactattcc agttcaccgt acaccctaaa tgcttacaaa ttggcgaaag 1781461 tgctacaatt tcatccccgt ttttgaagac ccaggctgat cttgactctt ctgactcata 1781521 ccaggcatcg acttgattaa ttttaaaatc aaagcgctgc ggctcttttg tcaactcatc 1781581 aacgctgaca acctgaacca tatcctgctt ccctgtcgat tttaataccg ggtcgagtgc 1781641 gaagcgaacc ataggcatga gcatactagc cgccataaaa cctcctacgc ctgtgagcgt 1781701 ataattcaaa aattgacgtc tggatatatc atgttttccg cccatctctt ctcccccctc 1781761 taagtcaccc ctgcaaactg actaaaatag aaaatattgc aataactcta gacaccctca 1781821 taatatatga atctctcagc aaggtcaata tagccaaaat attgtttata aggaaatgta 1781881 agtgttttta taaagtgctc cataactgta acaaaacgtt caaaatttca gcagtgcgtt 1781941 catccaatat ttttcttttt aaagagtcat ttaaatgctc taatggaaca gacgatgtaa 1782001 caatcatttt gcctaacgca tcctcagctc tccaactttc gtcagatgtg agcaggacaa 1782061 catgcggaaa ttccgttatc agctcttccc gcaaatcctt aagcccttga acggttattt 1782121 catttctatc aacatatgta taaggcggaa gtaaatatac ccgtcccttt aactgccttt 1782181 caagttcttc tgagagaagc tgcgtaaact cgcctttctc cgccgccatt ttaaaatggt 1782241 tattaaccct tatgttaatt aatggtatga cagcggtatc aatgtaatcc ttagcttgta 1782301 aatagtcctt ggcatcagtg attctccacc tcatcgttct ccccctttac ggcaacaagc 1782361 cttgcaattc actgcaaggc tggtcatatt atgtgagctg atttaattgg cgcgataatt 1782421 gttcaaatgc ctctttatca tgacgatcta acgcgtcgtc aatgtctttt aataattttt 1782481 ctctttggaa tgtggaaata gcgtgctcta aaatctgttc cgccaatccc tgatcttttt 1782541 tattctcaaa aaggtttttc ggaatatgcg ggttggactc cagcaccgcc gcatattcag 1782601 gtgagctgta agccgaacgg aaattaagct ggataaacaa atcctgctgt ttatttaatc 1782661 taatatcatg aaaagatttt tccgcgtcgg tagtcatgac attctcttta tagaaccgga 1782721 acggaacttc ttcaacacaa tgtgttgaca ttataatgcc tctcgggcaa aattcagcct 1782781 gctccacaaa atgaaccttc tccatgagag aatcatggct cattaagtag ttcaagatcc 1782841 aaacgcactc tcggcgcttt aactgataat ggtttaaaaa ccaacggata aaatcttttt 1782901 tctcattgac agaaacaggg gtctgcatgt aattccctcc tctatcgttc gtataatcta 1782961 tatacttata tgttccacat gaatggttaa tattcctgct tatctagaaa attcatcctc 1783021 gattcgcaaa atcgtttctt caagctcttc attggctccg tccatttcaa gaaccttttt 1783081 caaaagcggc agcgcttctt tttgaagacc ttcttctaat aggaagcttg cgtattcata 1783141 taagaaatct ctatcctccc ggtaatgaag ataggcagcc tcaaaggatt gttttgcttc 1783201 ctcgtattgc tctaattcag tatatgcgct tgcaagatac caattgtatt taggatcttc 1783261 ttcaccgtag cttcgaacct cttgaataag atcaatgatc tgatcataat cctcttcttt 1783321 gtgatacacg gcaagaagtg tatgaagcgc ctcgacaaag cccggatcaa gcgcaagcgc 1783381 ctcctgaagc agcttcttcc cctcttctga cttcccgatt ttcaaggcca ttttggcggc 1783441 ataaaggaaa agttctttgt tatattcatc atatctgatc ccctcttttg ccgtttttaa 1783501 tgcctcttca tacattcctt cagcttcata gcttttcgag agcggcatat aaagtgaagt 1783561 ataagatgga tcaagctcct ttaaatcaga cagctgctta atagctgttt tcacaagccc 1783621 cgcctgtaag gctgtaaaac catagccgaa aatcgtatta ggatcaggat tctcatcgac 1783681 agctttctca taccatggaa tggcatcctc aaattcacct gaggcactta acgattctgc 1783741 cagtctttga tggacattaa cgcccccgat ctcactctgc tcctcagccg ttgttttaaa 1783801 atattgaacc gcttttgcat aggctccctg agcaaagtaa agttctccca gtgcaaaatc 1783861 aataacaggt tcattgtcca gaatggactt tgcctggaaa agcttttgtt cactgacttc 1783921 gaataacccc tgcatctgat aaagatccgc cataagcagc aaactttccg gatatgatgg 1783981 atctgtttcc ggaatagtct ccagcacagc gagggctttt tcttcttcgt caatatctat 1784041 taaaagttca gcgtagaaat tcgtcagttc tgtttcattt ggatataaat catgtagatc 1784101 actaatcagt gaaatggctt tttctacatc gccccactcg taataaagct gggctgcaat 1784161 ggctttatct tcatcatgca gctgtttttc agccttcgag agcgtgttga ggcctttttc 1784221 tgtttcacct gcttcaacta attttatggc ttcttgaatc aatgtattca aatcggaccg 1784281 gtcctttctt ttcctataca acatcaacca tacaaaaaaa gctttatttg ttcgggttaa 1784341 tcttatcata attcagacga atgcccccgg caaataagat gcttctgtac ggaagggaat 1784401 tattgagtct tattagttta ccaaaagatc ttgagataga aaatgaaaaa aggaagatcg 1784461 ccctctgtac agtaaagcag ctctttgacc tgccggcttg taagtaaagc acatcccccc 1784521 ttttcgtttt tctatccgtt ctataagaca agctatgttt tttcgcctcg aattatgatc 1784581 tgcataaaaa atcctgaagt aaaacttcag gattttttcg aaagcttatt taaatgctcg 1784641 aagaaggttg gataagaaac gtgaatggca tccgtgtgct cgatttcaat cggctcctcc 1784701 gttatacagg aagcaatacc aagcatcatt ccgattcgat gatctccgtg gctggacact 1784761 gcagcgccgc ctttcaacgt ttgtttgcca taaaccttca ttccatctgc tgtcggttca 1784821 atttcagcac ccagcttgcg aagctcagaa acaacagtat caatacggtt tgtttctttc 1784881 acttttagct ctgccgcgtc cttaataacg gtggttcctt ccgcctgagt cgcaagaagc 1784941 gcgatgatag ggatctcatc aattaaacgc ggaatgatat ctcctccgat ttcaactgcc 1785001 tttagagatg acgtttctat aatcaaatct ccataaggct ctgcaccgct atcagcagat 1785061 ggtttgattt caagttttgc ccccatgttt tgaaggacat caataatacc tgtccgagtc 1785121 ggatttaaac ctacgttttt caatacaatt ctgctgtttg gaaccatcgc gccagcagca 1785181 aggaaaaacg cggctgaaga aatgtctcca ggaacaaaaa tatcagcagc tgtcagtttc 1785241 tggccaccag caatggaaac actcgtttga tcttcagaaa gcttaacgcc aaaagcagaa 1785301 agcatccgct cagtgtggtc ccgagattta tggggctctg ttacagttgt tgtgccctca 1785361 gcctgtaatc cggccagcaa aacagcagat ttaatttgcg cgcttgcaac aggtgataca 1785421 taatcaattc cttttaatga agcgccgctc actgacagcg gtgtaaactc tccgccggct 1785481 ctgccgtcga ttttagcccc catttttttc aaaggctcag tcacacgctt cattgggcgt 1785541 ttcgcaatgc tctcatctcc ggctaccgcg ctgtaaaaag gacggcccgc caatattccg 1785601 agcatcaggc gaatcgttgt acctgaattt ccgacatcta aaaggctttc tggctctttc 1785661 agggcatcga ttccttttcc gtgaatcacg acatcgctgc tgctttgctc aatgtgaaca 1785721 cccatttttc taaagcaatc gatcgtgctc agacaatctg ctcccggcag aaagttttta 1785781 actgttgttg tgcctgccgc tagcgcgcca aacataacag agcggtgaga aatggattta 1785841 tcaccgggaa tatgtatttc tccatgtaag gtctgcacct tatctcgttt cattttttcc 1785901 acctcaatca gcataaaaag tttcatattc cgcccgggct tcaatgcatt gttctgccct 1785961 tttgcggtcg tcatcagact gaaaactgat ccttaaaatc ccgttaatat cctctcgtgt 1786021 ttcgataatg cggatattcg tgatactgat gcgctccgca gctaagatcg ctgttatctc 1786081 ggatattaca cccggatgat cgggtacatc cacatataaa tcataaaatg caggtatcgc 1786141 tcccttctgc cgaagcggca gcccgtcgcg ataatccttg gctgttttaa aataacgaaa 1786201 tagattttcc gcatcttctt gttctacata tgtacggatc ttgtcaattt cacgaatcca 1786261 ctcatcaaaa cggtctaaga ttttatcttt attatgtaat aaaatatccc gccacattgc 1786321 cgggctgctt gatgcaatcc ttgtaatatc tctgaacccg ccggcagcaa aacgcttaac 1786381 aagcggatac aggttttccg aatgatgggt ttggtgaaca aggctagctg ctacaatatg 1786441 cggaaaatga ctgattacgc ttgtaacgcc atcatgctcc tctggcgaca tttccacaaa 1786501 atgggcattc gtccccttca gcaggttttt taactgttcc acagcttgtt tgtccgtttt 1786561 ctggcctggc gttaaaatat aaaatgcatt ttcaaacagg aactccttcg cagcggccac 1786621 tcctgattta tgtgaacccg ccatcggatg ccctccgaca aattgatagc ggctaggcag 1786681 cacttgatca gcgtaatcaa ccactttttg ctttgtgctt cctacatccg taatcaaaag 1786741 ctcatgttca attcctgaat gagccagctc ttcaagcata accagtgttt gttcaacagg 1786801 tgtcgcaatg attactgtag ctgcctcttt cacaccgcta ataaacgaat cagcacgatc 1786861 gtctatcacg cctaatttta atgccgctac cgcctgttca tcagagatgt cgattccgat 1786921 aatccgtttg ccgggatgat tttttttgat ggctagggca atcgaaccgc ctatcaatcc 1786981 gagaccggcg agcaatattg tatctttcat ttgattcata cgtcatcacc tggtttatag 1787041 actaaagagg tgatatttga tcacctctta taaaatttca gctaaaatgg caagtatttc 1787101 ttcattttgc tcttttgttc cgatcgtaat ccggagtgat gtcgggaaac ctaatgcgtt 1787161 tcctgaccgg acgatatagc ctttttccag cagagcctga aacagttcat cagcaggacg 1787221 tttaaagtca attaacacaa aatttgtctg tgaagggtag cactttaaac catgagtttt 1787281 cgcaaaatca taatactgct gaaggcctgc attattttgc tcgacacagg aagcaataaa 1787341 cgcttgatca tcaagtgctg caatcgccgc agcctggccc agacggctgg tattaaacgg 1787401 ctctctcgcc ggctcaatct ggcgaatcag gttctcgtca gcaattccgt atccgactct 1787461 gagcgctgcc agaccgtatg cctttgaaaa tgtgcgcaaa atcatcaaat tggaatactt 1787521 gcttaagagc ggcacggttt ccgggtaatc ctctgctgtt acatattcat aatatgcttc 1787581 gtcaagaacg acaaggacac gagaaggaac gcgctccaga aatgcgagta attctccttc 1787641 agatgtataa gtgccagtcg gattattcgg gctgcatatc caaacgactt gtgtctgttc 1787701 gtcgatggct tctaacatgg cgtctaaatc atgtgagccg tcgggacgaa gtgcaatttc 1787761 acgtacttca gcaccttcaa taaccgcatt atgtttatat tgcggaaaag tgggggcagc 1787821 agtaaccgtg tttgttttat cgtttaaaaa tgcccggcag atgatctgta tgatttcatc 1787881 agaaccgttg ccgaaaataa gtgatgtttc gctgacattg aggtgcttac tgagccttgt 1787941 ccgcaaagcg gcgctatacc cgtccgggta aagggctagc tgttgaatct catgatgaag 1788001 cgcctctttt gcagcctctg aacagccgta aggattctcg tttgaagcaa gcttcacaac 1788061 tttatccaag ccatattctg atttcactgc ttcaatcggc tttccaggct gataaggctt 1788121 cagctgtttt aaatgttctt tgatacgcaa atcagtcacc tcattttaaa ctgtacaagc 1788181 cgctaaacgc cattgcataa tcctcaaact cctgcagcgc ctgatttctc gtttcagcgc 1788241 tgatgagccg gtcctttaat tcttctattt ttctgacgag cgcacttccc actacgacac 1788301 cgtcactaat ttcattcatc tttatgacct gttcacggtt tgatataccg aaccctacag 1788361 caaccggaac agtgctgaga ttcttcacag tacgaatgaa cgggtacacg gatgaattga 1788421 actcattgcg gacaccggtc acacccagag aagatacaca gtagacgaac ccctcggctt 1788481 gttcaataat ggttttcaaa cggctttcgc ttgtcggcgc aactaaagaa atatacgtca 1788541 cctcatggct tttacattcc tcttgaaggc tgttgctttc ttctaatggc agatccggaa 1788601 caagcagacc gtcaatatga ttttcccgca gtaaagcgaa aaagtattct ttgttcaatt 1788661 gtaacacagg attataatac gtaaagagga taatcggaat attcactccg ttttttttca 1788721 tttctccgcc taattcgatt gcctttacga tattcattcc ttgatcaagc gcccgctttg 1788781 aagcccgctg gatcaccgga ccgtctgcaa gcgggtcaga gtatgcaaca ccaagctcca 1788841 atgctgtggc gcctgctttt tggagtgact tcgccagttc aatcgaaacc tcaggaactg 1788901 gatcgcccgc cgtaataaac gggataaaca atttttctga tggttgaaga tccaatttaa 1788961 acatgggctt tcacctcttc ttccaataca ttcattaatg tgttgacatc cttgtctccc 1789021 cggcctgata aacagacgag aatgagttga ccgcgatcca ttcctttggc gagtttgaat 1789081 gctttcgcta acgcatgggc agattcgatt gccggcaaaa tcccctcttt ttctgacaaa 1789141 agctttaatg catccaccgc ttcttcatcg gttatactgt cataagtgac acggccgctt 1789201 ttatgcaaat atgcatgctc cggaccgatt ccaggatagt cgagaccggc tgaaatagag 1789261 tagggctcaa taatttgccc gaactcatcc tgaatgagat aagtcaatga accgtgaata 1789321 acccctacgg ttcctttcga aatagtggcg gcatgaagag gtgtatcaat tccttttcct 1789381 gctgcttcag cgccgatcag ttcaacatct tcatttaaaa atgcctgaaa catacccatc 1789441 gcattgcttc ctccgcctac acatgccact actttatcag gcatagtgcc ttcaatacgt 1789501 ttcaactgat ccttcgcttc ctctccgatc attttttgaa attcacggac cacttgcgga 1789561 taaggatgcg ggccgacaac tgatccaatc atataaaagt gatcctcaca atgctgaacc 1789621 cagtaccgga tcgcctcatt tgtggcatcc ttcaatgttc cgtttccgct tgttacaggc 1789681 actacctccg ctccaagaag cttcatgcgg aaaacgttca gagactggcg ggcaacatcc 1789741 tcttcaccca taaacacagt acaggaaaag ccgaatttgg ctgcaactgt tgcagcggca 1789801 acaccatgct ggccggcacc ggtttcagca atgattttcg ttttgcccat ttttttagca 1789861 agcagcgctt gacctagcgc attattgatt ttatgagaac ctgtatggtt taaatcttct 1789921 cgtttcaaat agattttcgc gccgcctaag tattcagtga ctcgatcagc gtatgttaat 1789981 gcagtcgggc gtccggaata gtcctttaac agcttataat actcttcacg aaaagcggga 1790041 tcatccttga tttgtttaaa tgctgtttgt atttcatcta acggctgcat gagtgtttcc 1790101 ggaacaaact ttccgccaaa atcaccgtat ctgcctattt cattcggata tggatacata 1790161 tcggttcatc ctttcttcta aaagcctcat cagattctga tctttttgtc cgtttttttc 1790221 aattccgctg gcaaggtcaa ttccttctgg ctgccatttc aataggcgtg tgatgctatc 1790281 cggattcacg ccgccagcga taaagcagcg tttaccaata gccgcctgct gatattccgg 1790341 cacacattcc caagaaaatg caacaccagt tccgcctcta gaccctttta cagatgaatc 1790401 aatcacaaag ccgtcaacat tatctttaaa gcgggctatt tcttgagttg tgttatcttg 1790461 atggtgaagc gccttccata tttcacagcc tgtcagcttg cgaagagcag cagcatccgc 1790521 cggtttttca tcaccgtgaa gctgaatgac gtcgagcttc aagctcttgg caatacgtga 1790581 catcgtctct attgattcat taacaaaaac acctgcaacc tgtttttcga cacgaacttg 1790641 gttcagccat tttttcacat cttccggaga tacttttcgt ttgctttcag caaaaataaa 1790701 tcctaggtaa tcagcctgtg attccgccgc aagctgcaaa tcctttagtg accgaatacc 1790761 gcaatatttt aatgccggtt tcttcacaac ctcactccct aaacaaagca tggattgctt 1790821 tacgctgaga agtttgtctc atcaatgatt caccgataag tacagctcgt gctccatgtt 1790881 ctttgacaaa tgttaaatgt tctaaagaac cgattccgct ttcgctgaca agcagtgatt 1790941 ctttcggagc aagagatgcg atttgttctg tctgcatgat agaggtttca aaagttttta 1791001 ggtttcggtt gtttatgccg agaatatcag gcgtgaatac tttcaatatt tgttctagcg 1791061 ttgttgcatc atgaacctcc actaacacgt ccatctcctt ttcacctgct tcaagatata 1791121 attcatgaag gtgtaaggga tcaagcactt cgccgattaa caatatggca tccgctccga 1791181 ttcttcttga ttcctccact tgaagagaat caataataaa atcttttctg agtacaggta 1791241 tcgaaacagc gcgctttacg tctgataaat agctgttttc cccttgaaaa aacggggtgt 1791301 ctgttaaaac ggaaagcgca tctgctttcg cagtttcata gtcttttgca atccgcacag 1791361 gtacaaaatt ctctttaata agcccttttg acggcgacgc tttcttcact tcagcaatca 1791421 acccgataaa ccgattcagg cttgccagcg cctctttaaa tgaacgtttt tcgaaaggct 1791481 gctctaccgg cagaaccagt gttttcactt cttctttctt ttgtttgatg attttttcaa 1791541 gcatagatct cttcctcttt ctgctttagt cgttcaagct gcgcggcagc gcctccgctt 1791601 gtaatcgtct ctaacgccag ctccgttcct tccttcagtg aggcggtaat tcccgccgtg 1791661 taaatcgcag cacccgcatt aaaagccgta atagataaag cggaactgct gcttttattt 1791721 tcaaaaatat tctgaatgag ataagcgctc tctttcggag actgcacctg taaatcttca 1791781 agtctgccat ttgtgaaacc gaaatcttcg ggtgaaacgg tatactcccg gcgctctccg 1791841 tcctttaatt caatcacgtc ggtcggtgct gtaattgaaa gctcatctaa accgtcacgg 1791901 cttgatacaa acataacgtg cttcggctga aacgtctcca gtgcgcttgc catcagtcca 1791961 gctttttcaa cagaatagac cccaatcacc tgacgcttcg cctgtaaagg attgctgagc 1792021 ggcccaagca gattaaatac cgttctgaaa cctagctctt ttctagtacc tgctacatgt 1792081 ttcatagacg aatggtaaag cggcgcaaaa agaaatccca tgttgtttgt ttcaatgctg 1792141 cttttgacct tttcgggagt ggtttgaata gaaacctcta gctcctctaa aacatcagcg 1792201 cttccgcttt tagaagagac agagcgattg ccatgcttag cgattttcgc accagctgcc 1792261 gaggcaacaa ttgccgaggc cgttgagata ttaaaagtgg aaataccgtc tccccctgtt 1792321 ccgcatgtat caacaatatc aggaagtcca tcgactgtaa gagcgtgtgc ccgcattgcc 1792381 ttcacaaaac ccgcaagctc ttctggcgtc tccccccgat gagcaagaat tgacaatatc 1792441 ccccccattt cagaaggagt catttccgct gccatcatca tattcatcag cgtttcagcc 1792501 tcaccggcag taagggtttt tccgtcaacg cacaattgta gaaatctgtt catcagcttt 1792561 atcctccttg ctatgaaaca tgtcttctgc aatatgaatc gttttcagca gcgcaccggc 1792621 tttattacag ctttcttcgt attcggcttc cggaacagaa tcagcaacaa tgccagcacc 1792681 tgcctgtatc gatgcaacac cgttctttac actcatcgtg cgaatcgtaa tacaagagtc 1792741 gatattcccg tcaaacccaa tgtaggcaat acaccctccg tatgtctctc tcggtgttgg 1792801 ctcgagttct tgcaaaagct gcatggcacg gattttgggt gcgcctgtta aagtccccgc 1792861 cgggaaagca gacatcagtg catcgacagg atgaacccct tttttcaatc ggcctgtaac 1792921 caccgagata atgtgcatga catgtgaaaa ggaaacaatt tttgtgaact ccggcacaga 1792981 aacagaacca tactctgcta ctctgccgat atcgtttcgg gcaagatcaa cgagcatgta 1793041 atgctccgct ttttcttttt catccttcat gagctcaacc ttcagtctct catcttcagc 1793101 tttgtctgca ccgcgttttc tcgtaccggc aatcggatgg atttctaagt gcccgtcttg 1793161 aacgtgtatt aaccgttccg gagagctgcc gactatttct ctgtctagca gtttcatata 1793221 atacatatac ggcgaaggat tgacgatcct aagcactcgg tataactcaa aagcatctgc 1793281 ttttatcggc acctcaaatt tttgtgataa aacaccctgg aagatatcgc ctgcttttat 1793341 atagcttttg attttttcta catcagccat aaaagccgat ttttcataat tagaagatac 1793401 tgtctcaaag ctgggtgtct tgtatgaatc agcagaaaga aacagctctt ttatgttttt 1793461 ttggtccatc attttttcaa tgagattttg aagctccaga tgattttgat ggaatacatc 1793521 cattttttcg ttttttgttt cctctccagt gagccttgca tattggataa agtggacgtt 1793581 tttggtttca tgatcatacg caattaatgt ccggcaaaca aacagcatac acttttccat 1793641 gtctgtttct ttggtatgcg aaggaacaga aggctcaatc agcgggatca tatcatagct 1793701 taagtacccg acagctccgc cgacaaaagg aatgccaagc tcaggtgttt tgattttgta 1793761 tgtggtattc atccagttca gcacttcttt tagttcattt cctgtgtaaa gagatttgct 1793821 gtcctgatca gcggccgaaa aacggccctg ctcttcttta attgtgagaa atggattcag 1793881 gccgataaac gaatatctgg accaagtgga tgtatcgtcc ttgctttcaa gaagatacgt 1793941 aatctccctg tcaagcttct ctatcatttg aatgggtgtc agtgtatcga ctgtgaaggt 1794001 ctccacaatc ggtatcgtgt ggtgggacaa gctgtcctct aaaaatgcgg aaatgtttga 1794061 ttggaaattc attgctctca ctccttatgg caaggagaat gagaagatgg catgagagga 1794121 taaaatacta tataacaaat aaacccaaaa gaaagacttc ttttgggtag aataaacata 1794181 atgtctcagc tcaactaaac tcattctctg ctaccctatt ctctaactca actcattcta 1794241 attgctttat acacactctt gtgtatttct aagctgttct tatcgtatta caattcagta 1794301 ttttttgtca atgataaatc gggcctcaat acgacaactt tttctaaata tacatgtctg 1794361 atctgatcct gagggacatc tgtctggacc gtcatcatga ctcttatgca ctttttcaga 1794421 ccgcctgtta cgtccatttc ctgcatacat gttaccggta catactgcca tcctgaaagc 1794481 tcgcgaacag cttttgccgg gaaaacagcg tgcaaatcag gtgtagccga cagaagcatt 1794541 tgaacaacat cttccggttt tgtatgattt tcttctatga ttttctctaa cagctgttta 1794601 gttttttgta aaatttcttc ttcagtatcc cgttcaactg tagttgctcc gcgaattccg 1794661 cgaatcatca tgatgtctcc tccaatcgcc atttgttcag ccagctctca agttcatttc 1794721 tggaaaatgt atgatcagca actttcccta attcgttgag cacaataaac tgaatcttcc 1794781 cgccacgggt tttcttatca ttcatcatac ggttcaagag aaccgaagtt tccgtctctt 1794841 ttctgatttg acttggataa cccaggcttt ttagccagct gaccaaacgt tttctgtcca 1794901 tttcacagcc tacagtcttt tcgcttatat ataaagcaaa ctgcattccg agggctacgg 1794961 catcaccgtg agtgatctgc ccatatccat attccgcctc aacggcatgg ccgagcgtat 1795021 gcccaaagtt taagtaagct cttatcccct cttctttttc atcctgctga acgacagacg 1795081 ctttaattga aatgccttta aaaatcatgt cattcagctg atcattagtg atatcacgca 1795141 gtgagtggat attcagcagc tcctccagaa acgctctgtc atagataaaa gcgtgtttaa 1795201 tcacttctgc cattccggac ctaagctctt tttcaggcag agaacgcagg aaatctgtat 1795261 catagagcac ggctttcggc tgataaaacg caccgattag attttttcca agcggatggt 1795321 tcacggctac ttttcctccg actgcgctgt catgcgccaa gagcgtcgta ggcatttgga 1795381 tgaaatcaat gccgcgcata aaagtggcag ccacaaaacc ggcaagatcc cctacaacac 1795441 cgccaccgaa tgcgatgatg catgaggagc gatccatatg aaaacgaatc gcttcactct 1795501 gcaattttgt gtacatgtcc atggattttg cctgctctcc actcggtacc gtcacttttt 1795561 tcacaggcca tttttcttgc agcaaatgga gcatttcatc accatacagg cggtccactt 1795621 cttcatccgt gacaaacata atccttgtta aaggcctgtt taaagaggtt aatagttcgc 1795681 aagccttttt tctgatacct tgtccgataa aaacaggata tgacgaggaa gcagtttgaa 1795741 catgcagtgt cttcattaaa attccctcga cagttttctc atattctcca cattttctct 1795801 aatgcggtca atttgatcta atccgaattg ttcaacgact gcgttcgcaa tttcccaagc 1795861 gacagccgct tcagcgacta cacttgccgc aggaacagca cagctgtctg aacgttcaat 1795921 gctggcagaa aacggttctt tcgtttcaat atcgacactt ttcagcggtt tatacaaagt 1795981 cggaatcggc ttcatgactc cgcggacaac aatcggcatc cctgtcgtca tgccgccttc 1796041 cagtccgcca agtctgttag tagcacgggt gtatcctttt tcctcgtccc aaatgatctc 1796101 gtcatggact tcgcttccat ttcgccctgc tgcctcaaat ccgatgccga attccacacc 1796161 tttaaatgcg ttaattgaca gaacagcggc agcaagcttg ctatccagct tgcggtcata 1796221 atggacatag ctgcccacgc ctaccggcat tccctcgaca atgacttcta ctattccgcc 1796281 gatggaatct ccgtttgcct ttgcttcatc aatggcagcc atcatttttt tgcctgcctc 1796341 ttcatcgtag catctgacag gagactcttc cgttacacgc tgcaagtctt caattgacgt 1796401 atactctgtt ttttcagctt taacagcgcc aatttgcaac acgtggcccg ccaccttaat 1796461 gccaagctca gaaagaatct ttttagctac agcccctgcc gccactctga cagttgtttc 1796521 ccttgctgaa gaacgctcaa gcacatttct catatcacga tgattatatt taattgcacc 1796581 gtttaagtca gcgtgcccag gtctcggtct ggaaatctgg cgcttcattt ccttttcttc 1796641 atcttctgta atcggagcgg cgcccatgat ttttgtccaa tgcttccaat cgttattttc 1796701 aactacgaga gcaattggcg aaccgagtgt acgtgcatgg cgcaccccgc tcataatttt 1796761 ggcctggtct ttttcgatct gcatgcggcg gccgcggccg tgtccttttt ggcgtctggc 1796821 aagctcaaaa ttgatatctt cctccgttat gtaaagcccg gcaggtacac cctcaataat 1796881 ggttgtcagt tgggggccgt gtgattctcc ggctgttaaa tatctcatga cttcttctcc 1796941 cttcatcgca ttaacgcttt taagtaagac tactataaca tatttttcag caaaaagtca 1797001 gtctatcttt tttgataaaa gaatgtatcg gctgggacta ggccaaattt ctcgggattg 1797061 aagatttgct cggtgctgcc gacaaaaaga actccattct tcttcaagct atgtgccatt 1797121 tttaaataca gctcttcctt cgcgctttct gtaaaataaa taaatacatt gcggcacacg 1797181 attaagtcaa agtcttgttc ataacgatcc gccagcaaat tgtgcttttt gaatgtaata 1797241 ttctttttga tttccgtttt cacttcataa cttctatttg cgttttgcgt aaaataacga 1797301 tctttcacag atagcggcac ttcctgtaaa gaccgctcct gataaacgcc ttttttcgct 1797361 ttttccaatg ctttttcatc aatatccgtc gctaaaatct gatagcccgg aagacctttt 1797421 tgctggtcca aaagcatggc aagcgtgtat ggctcctccc ccgttgagca ggcggcactc 1797481 caaattttta aaggcctaga ggtcttgatt aacggcagaa ttgcagtctc aagaacttcc 1797541 catcttttat aattacgata aaattctgaa acattgatcg tcattctgtc caatgtttca 1797601 tttaagagag cttgatcctt ttccaatgcc gcagcaaagt ccttaaagct ttggaacccc 1797661 tttttctcat aaagtgacgt tagccttctc ttcatttgtg cttctttata tagtgttaaa 1797721 tcgactccgg ttaattgttt ccatttcgtt gtaaatacgc tgtatgtatc catctctact 1797781 ctcccagtct cgctgtcttt ttgtcctagt atagcttgtt ttatcaggaa attgtattgt 1797841 ttcaataaaa aaatcagctt ttcagctgat tttagatcgt tgggaaaggc agaggtctga 1797901 tgcacactgc cattcaaccc tttattcact ttaatgtaaa cctttacaaa acagaacaaa 1797961 aaccggcggc gttatatgtt gccggctctg ttgcttattt tcacaatgat taatagatcc 1798021 agcctgccat aagctgctga tatgatacta attcttcatt cttaaagaaa atgttaatct 1798081 cgcgttctgc actttcgaga gaatcagagc cgtggatgat gttttttccg acaaacatgc 1798141 cataatcccc acgaatcgta ccaggtaaag cttctttagg gtttgttttc ccgatcagct 1798201 gtctcgtcac ttcaatgaca ttttcgcctt cccacaccat tgcgaataca ggtcctgaag 1798261 taataaactc aacgagctct ccgaagaaag gcttaccttg atgttcggcg tagtgtttct 1798321 cagccatttg ttcagtcact ctcattaact tggcgccagc taattgtaag cccttacgtt 1798381 cgaatctaga taaaatgtcc ccaatgagct gacgttggac accgtctggt ttcaccatga 1798441 taaaagtctt ttccatcata ttctccaccc catcattatg tatgtatagg ctttcacact 1798501 gcacaccgaa atcgtaacat ctttctgata attaatcaat ccggggcgga gaaatttctt 1798561 aatatctaca aaaattaaaa ttttctttta ccgatatatt ttgcgatggc tgcaagagac 1798621 gagcgtgcgc gccctcgagg aagcgtgttt aatttctgaa aagctttctg cagatacatt 1798681 tcgcttactg ccatagatgc ttcaattgca tctgtttttt tgatttcttc aatgattggt 1798741 tcaagctgtt cctgcgttgt ctcactgtta atcaatttaa gctggttttt taatgcagga 1798801 tttttcaggg catacagcac tggcaatgtg acgtttcctt gaagcaaatc tcctcctacg 1798861 ggtttaccca gctcttcctc agttgaagta aaatcaagaa tatcatcaat aatctgataa 1798921 gacatgccga cgtaataccc aaaccagtac aatgccttat gaatcttctc atcagctcca 1798981 gacgcaatgg caccaagctg gcagctgacc gcgatcaaga gagctgtttt tcttttgata 1799041 cggcggagat acgttctgag attttgttcc atgttgtatt tgtctttgat ctgctcaatt 1799101 tcccctagac aaacttcaac gatcgtctgt gacaaaatcc tatgggcttt cggttcgtta 1799161 attctcgtca tcatttcaag agatcccgca agcatataat cgcctgtgta catcgcaata 1799221 cgattgtccc actttgcttt gattgtcggt tttcctcggc gaagctctgc atcatcaatg 1799281 acatcatcat gaaccaaaga tgccatgtga atcatttcca gagtgacggc gacatattta 1799341 atcttattaa tatcataatc gccaaacatg ccagaaagca gcacgaaaac aggccgaata 1799401 cgtttccctc cggcctgcag caggtgaaga cctgcctcgc ttaaaagcgg gtaatcggaa 1799461 cgtacggttt gttcaagttc tctttcgatt acatcaatat cgtcatttaa aaaagagtag 1799521 gccattttaa atttcatatc attcacccaa acatctgtgt tttcatttcc atccgatatg 1799581 cgtggcagcg actccgccag taaacgaatg atatttaaca tttttcaggc ccgcctcttc 1799641 aaacaggcct gccagttcct tcattccagg gaaatctctg gctgattctt gaagccaaga 1799701 atattcttta tagctcttcg caaacagttt cccgaaaaac ggcataatat acttaaagta 1799761 cataaagtaa gcctgtctga atccgaacat ttccggctgg gacgtttcca gacataccac 1799821 ctgcccgccc ggcttcacta cacgtctcat ctctttcagt acagtcaagt aatcagggac 1799881 attgcggagt ccgaagccaa tggtgacata atcaaatgta tcatcatcaa aaggaagctc 1799941 catcgcattt ccgtgcagca gttcaatttg gctgaatccg ccgtctttta ctttctgctc 1800001 gccgacactc agcatatttt cactgaaatc caagcccttg atctcgccgc ttttgcctgc 1800061 cgcttttgca agagcgatcg tccagtcagc cgttccgcag cagacatcaa gtgcttttgc 1800121 gccttccttt acattcatga tgcgcatcgt tttgtcgcgc cattttttat gctgctgaaa 1800181 actgatgaca gagttcattt ggtcataatt tttatatatt ttttcaaata ctccgtgtac 1800241 gcgctgttct tttgagtcct gcataatggt ttacccttct tccactttct gatgataggt 1800301 ttgatcttgg ctgattgtct tcagacggtt tattaaaatg ttctgaatag gtgaatttag 1800361 aggcagaagt gactcaatgc tgtttttcgc ttttttaaaa caatcttcta atatctcttc 1800421 ttttgttttt cccagctgta taaaactgcc gatcacatcc agaaatgcat catttccgtt 1800481 cataagccgc ttaaatacaa aaaaatcact cgacagcttt ttccagcgcg ggaggttgaa 1800541 gtgttccgcc acacgatgga ataaagctga ttcaacgatg ccgacacttt cgaaaaaatc 1800601 gttttcgtcc ttgaaagaac ggtcatacag acgaatttta tgttcgttga tttctttaat 1800661 ggctgtagca agcgtccgaa tcatgtagat atccttcatt tcagatagta aagagtagta 1800721 cagcccgctg aaataatcgc ccgcgagaac agtcaattgg cggtttttgt tttcgtctcg 1800781 ttttatgact ctagctgtcg tcacttcatc atgggtatca agggcgcttt gtacaagcat 1800841 cgctgttaca atataatttt ctctgtcgtt gttttttatg tcggcttctt caaataaagc 1800901 atgaaaaaga agaagcttat cctcatcaat tttcggcgca gaaatatgct tcgctaaata 1800961 aggatgagac agcttttgtt ttaatttcgt gttcagattg gctaaagttc cgtagatgtc 1801021 ttgcaaaaat atcacccttg tccccaaatt cacatttatt tcttaatcta tgtatgagtt 1801081 ttatcttttc attcgcttac gcaggtatca ttatagcata aaaaaaagaa attggctgta 1801141 tcctcccgct gtttgcgagc atttgctttt aacagcgggg acagccagct tatttttttt 1801201 cgcttttcat ttctccgtac gcggtttgaa tcagtgcctc tcctctgact ttaatggcag 1801261 aagtatgctc tgtaaactga gcgatgatca cttctccctt gtcgagtttt tcggaatggt 1801321 gaaactttgt gtctgttcct cttgtcaggc cgatcacatt cactccgtcc tcaacggctt 1801381 taatgacgac aaaatcactt gaatgctttt ggttcattta tagcaccctc tatctttatt 1801441 agtcctggcg tttaatatgt tccaatactt ctgcacgggc agcggcatca tctttaaaaa 1801501 cgcctctgac tgctgaagtc acagttttcg cacccggttt tcttacaccg cgcatcgtca 1801561 tgcacatgtg ttccgcttca accactacca ttacgccatg cggatcaagc gtttctacga 1801621 tgctttctgc aattgtagaa gtgatgcgtt cctgaagctg cgggcgcttt gcaacggctt 1801681 caacggcacg tgccagtttg ctgagtcctg tgacctttcc gcctcgcggg atatatgcaa 1801741 catgtgcttt tccataaaag ggaacaaggt gatgctcaca catagaatga aacgctatat 1801801 cttttacaag aacaagctcc tcatggtttt caccgaagat agtctggaaa tgttcttttg 1801861 gatcttcatt caagccggag aatacttcgg catacatctt tgcgactctt ttcggagtat 1801921 caagaagccc ttctctattc gggtcttctc cgatcgcttc taaaatttga cgaacagctt 1801981 gttcgatttg ctctttatta acttctttca tgttctatgt cctccaccaa tgaatacatt 1802041 taatttcgat tctagcacat atgccccgct aaaagcaaag tgaatgccct gtcaggaagc 1802101 ccatgctctt gaaatatgaa aagcccctta gaaaggggct tttctgtgaa gaaataaagt 1802161 gtatgtaagc tagatgcata cacgatctat attcacaatt attttccggc aactgcgtct 1802221 ttaagcgctt tacctggttt gaaagcaggt actttgcttg ctggaatttc gatttcttca 1802281 cctgtttgag gattgcgtcc tttacgtgca gaacgttcac gcacctcgaa gttaccaaaa 1802341 ccgatcagtt ggattttatc accgttttta agtgcatcta agatcgtatc aaaaacagag 1802401 tcaactgctt ttgtagcgtc ttttttagac aattcgcttg cttctgcaac cgcattgata 1802461 agttctgttt tgttcatgcc tttcacctcc tcccaaaagg atacattcag ttcgtttatt 1802521 atcatttctt cacagttcag tctgattcta aacctgtctc agaaaaaaat gagagcaagt 1802581 aagagaaaga caattaaacg gctttttaag aaaaactgca ctctgaggaa tgtttgtcca 1802641 acaaagtgaa gaatttctgt atgtagagta acacatataa aaagccatat caagcatttt 1802701 aaagcgtcaa tcccttgctc gtcaaggatt taaggtgatt taccgaacga atattccttt 1802761 ttttcctttt ttcatcctat tccttgatcc ttttccatta ttaagagcaa agaaaaaaga 1802821 cctcccattc tataaagagg tctaccggta ttacaggatg atggcgatta agccgccaga 1802881 gccttcgttt atgattcttt ctaatgtttc ttttaattta taccgtgcgt tttcaggcat 1802941 caatgacagc tttgcctgaa tcccttctct cacaattgag ctcagcgacc ttccgaagat 1803001 atcggaattc cagatggaga gcggatcatc ctcaaagtcc tgcattaaat agcgtacaag 1803061 ctcttcactt tgtttttccg ttccgataat cggggcgaat tcgctttcga catctacttt 1803121 gatcatatgg atcgacggag cgacagcttt cagcctcaca ccgaatcgcg agccctgcct 1803181 tataatttcc ggctcatcga gactcatatc agctaaagca ggcgctgcaa tgccgtatcc 1803241 cgtctgtttg accattttta aggcatcaga cacttgatca tattctgttt tcgcatgggc 1803301 gaagtcttgc atgagctcaa gcagatggtc tcttcctctg atttcgacgc ccacaacttc 1803361 ttttaggatt tgatcatata gatgatcagg cgcgtacaaa tcaatttctg ccaccccttg 1803421 gcccagctca attccggcta atccggcact ttcaatgaat tcaaactcgc tgaattggcc 1803481 gacaaccctg tctacgtccc ggagccgttt aatatcctta accgtttcct tcacggactc 1803541 ctgatagctt tcacgcaacc aatggttttc tttcagcacc attacccagc ttgggagatt 1803601 gacattcact tctagcaccg gaaactcgta gagggcctct ctgagcacac tcagcacatc 1803661 tgattcccgc atgctctcta cactcattgc caataccggg atatcatatt tttcgcttaa 1803721 atcctggcgc atggcttccg tttccgggtg atacggcctg actgagttga tgaccataat 1803781 aaaaggtttg ccaacctctt tcagctcttc aatgactctt tcttcagcct ctatatagtc 1803841 acttctggcg atatctccaa tggtgccgtc tgtcgtaatg acaactccga tggtcgagtg 1803901 ttcttgaatg acttttcgtg tgccgatttc agcagcctca tgaaatggga tcggttcttc 1803961 gtaccaaggc gtattgatca tccgcggccc gttttcatct tcatatcctt tagcgccggg 1804021 cactgtgtaa cctacacaat ctactaatct tatattcaca tcgagtccgt ctgacacatg 1804081 aacagacatc gcctgattcg gaacaaattt aggctctgta gtcataatgg ttttgccggc 1804141 tgcgctctgc ggcagttcat cctgcgctcg ggcccggtct gcttcgttac tgatattcgg 1804201 gagcaccaca agctccataa attttttaat gaacgtggat tttcctgtac ggacagcacc 1804261 tacgactcct aagtatatat cgcctcctgt tcgttcagcg atatccttga aaatatcgac 1804321 cttttccaag tgatcccctc ccggacttcc tatccttttc aattttatta agctctttca 1804381 atcaaacaca ggacactata tgtgtatgac gttgtcctat ttgaatatga catctttaga 1804441 aaatttctca tcctcaatct attaatataa aaaaaccttt ctccctattt gtatgcaagg 1804501 gagaaaggtt cattcctttt tcatatcatt ttctaaaaaa acaggttcct gtttgtcatt 1804561 taccgtatat tttacagaaa acgcggggac aaagggggtt tcatgccaaa tcatatcctg 1804621 gatttcagtc ccgggtttaa acgttttttt gctttttttg aggcaagaag ccagctcagt 1804681 ccggtaatcg gcatatattt ctccgtctcc gtcaatcata agcggcaagg aattccctga 1804741 gattgggctt gtcactgtaa gagagctgcc atccccaagc ttcttctcat cgagtgtaaa 1804801 taaatcacga gatagcacat ccttgtaagg cggatattga tgctcctgac gatacatttg 1804861 gatgcgcaat ttcacatcgc gaattttttc tgccatcttt agatcaatta atttaacagt 1804921 cggatcgttc tctacgtcaa caagcacgta ttgatagtct cccccgcttt caaatgccgt 1804981 acttggaggt tcagctatgt atcttggcgc taaccggtta aagtctatcg gatatttttg 1805041 atatagcggt gtcgacatat ctttggtttg aataggaagc agccctccat ttgccttttg 1805101 aaattcatca acagcagatt gaacctgctt tagctggtct tgataaggaa tggcatgcac 1805161 actgcttttc cgttcatttg gatataaaca tccggataaa aacacgactg ccgcaaaaat 1805221 gattgcgcac ttcagtttac ccatacagca cttcctttta cagctttatt cattgacagg 1805281 gccgctaaaa accacgacaa acacaataat tccagatatg agcatacaca tgtatgcgaa 1805341 tgatgaaatc gcaatcttca aaaaacggtt ttggcactta aagcggctta aatagatgga 1805401 agctacagcc agaaacatca gacccatgga ccctagagca aaccacattt tcatcaatgc 1805461 cagattcaat gacgtgcgcc tccccgatat gtaagatata agcgttatat tatattttaa 1805521 tatacagcgc cggaaaagat caaccagatt ttccatccat tgatagaaca aaaaaactga 1805581 agcaaagagg gggaccttcg cttcagtcaa cttgactata ttcacctgca cgtttaagaa 1805641 acactctctt ggacttcgat gctatagtat gcgacttggc atacagatgc atcctctatt 1805701 gcctaaatcg gcaaaatgtt tcaggagatc ccaagacttg ggtgttcttc tgtttttcgg 1805761 gctttcgttc aattaagata tgcgattcac catttgattg acacttttac ttcacttgat 1805821 tttcaaacgt atttaccaaa tcctccatct cgtgggtttt ccctctcgcc attaaagatt 1805881 caacagcggt ttccactttt tgtccgttga ataggacctg atggagagct tctgtaatcg 1805941 gcattttaac atcatatttc ttcgaaagct gataagccgc tttcgtcgtg cggacgcctt 1806001 cgactaccat tcccatctct tcaagaacat cttcaagctt gtaccctttt ccgagcaaat 1806061 tgcccgcacg ccagtttctg gaatgaacac ttgtgcacgt cacaatcaga tcgcctactc 1806121 ctgtcaatcc agagaacgtc aagggatttc cgcccatttt cgttccgagt ctcgcgattt 1806181 cggcaagtcc gcgtgtaatc aaagcagctt tggcattgtc accgtaccct aaaccatctg 1806241 taattcctgc agcaagggca ataatatttt ttaaagcccc tccgatttca actccgataa 1806301 tgtcaggatt tgtgtacacc cgaaaattgt gattaataaa tagatcctgc acctcttctg 1806361 ctgccctcat gctctttgaa gatgcagtaa cagttgtggg gtgccgcagc cctacttctt 1806421 ccgcatgact cgggccggaa aggacaacga tatcttttct gacatcactc gggagctcaa 1806481 tttccataat ttcagaaatg cgcagaagtg aatctggctc aatacccttg ctgacatgaa 1806541 caaagactgc ctttttcgtt ataaaaggga cagcctgtct cagcacttcc cgaattgctt 1806601 ttgtcgggac cgcaacgata atgacatctg cgtctgaaac agcctctttc atatctgttg 1806661 ttcctttaat ggatgtagac agcttaacat tcggcaaata atctttgttt tcatgcaact 1806721 cattaatttg atgaattaaa tctgcacggt gagcccacac acacacttca tttccattat 1806781 cagttagaac taaagccagt gctgttcccc aactccccgc tccaagcatt gtgacttttt 1806841 tcatgtttga ttcacacctt tttattttct agctcttgca aatattttga ttggtgtccc 1806901 ctcaaaaccg aacgcgtctc tgattcggtt ttctaaaaac cgttcgtatg aaaaatgcat 1806961 cagttccgga tcgtttacaa acacaacgaa gcttggcggc tttaccgaca cttgagtcgc 1807021 atagtaaatt ttcaaacgag aaccgttatg agtcggtgtc ggattcattg ccacagcgtc 1807081 catgatgaca tcatttaaga cgtttgtttg aactcgaagt gaatgatttt cactagcttt 1807141 gataatcgca ggcatcagag tatggatccg ttttttcgtt aaggcagaca taaataggat 1807201 tggcgcataa tccagaaatt gaaaatgatc gcgaatattt tcttcaaatt ctttcatcgt 1807261 gctctcatct ttgtcaacag catcccattt gtttacgacg atgacgacgg ccttgcccgc 1807321 ttcgtgtgca taaccggcga tacgcttgtc ctgttcaata atgccttctt cgccatccag 1807381 cacaaccgcc acgacttctg agcggtcaat cgcttttagc gcccgcagta cactatactt 1807441 ctcagtcgtt tcatagactt tccctttttt tcgcatacct gcagtatcga caatgacaaa 1807501 ctcctgctgg ttgtaagtaa atgacgtatc aacagcatct cttgtcgttc cagccacgtt 1807561 gctgacaata acgcgttctt cgccgagcat cgcattcaca agtgaagact ttccgacatt 1807621 tggacgtccg atcagacaga attgaataac ttcttcattg tatttcgttt caggaatgtt 1807681 tttaaaatgc tctgcaacgg catccagtaa atcacccagt ccgagtccgt gtgttcccga 1807741 aattggatac ggctcgccaa agcctagcga ataaaaatca taaatattcg ctctcatttc 1807801 tgtgttatcc agtttattaa ccgctaaaac aacaggcttt tttgtgcggt acaaaatttt 1807861 cgccacttct tcatcagcag ctgtcacgcc ttcacggccg ttcaccataa aaataatcac 1807921 gtccgcttca tccatggcga tttcagcttg ctggcgaatc tgcgctaaaa acggctcatc 1807981 accgatatca ataccgcccg tatcaatcaa attaaaatca taattcagcc attcagccga 1808041 gctgtatatc cgatcccttg tcacgccagg ggtatcttct actattgaaa ttctttctcc 1808101 cgcaatccgg ttaaagattg tggattttcc tacatttggt ctcccgacaa tggctacgac 1808161 aggtttaccc atagtaccct tcctttcaat ccagccgctt tcatttttac ataaattttc 1808221 aaccggttat taaaatcatt tcattcactt ttatgaaaag aaacccttca gaggaagggc 1808281 ttaactcatt tattatatca gtttttactg ggatcacaac tattcttaaa aatgtttcac 1808341 gatcaaatac acgtcatctc cgattctgtg agctattcca tcaaggatcg cctcaagatt 1808401 tttagcgaaa agctccatct ccttttggtc attgcaaaaa aagacaggtg ctccccctgc 1808461 aacccgattt cgatttgtcg tgattacaga caaaatcact ttcgtaagag attcactcat 1808521 cctatcacct tatcctgatt cttgataaat tcagtcggca ttctaatcgc attttccagg 1808581 gttggaacat tgctaataat ttgaacagcc gtttcgggat ggtgaatttg cgggagaaca 1808641 aatactgcca ctctcccatc atttaaatcc cgttttgcaa ttggtgtcaa agatggctct 1808701 cctgaatccc gataaacccc gagcacattg gaaacatcaa ataaaatggc ctgacgctgc 1808761 cctaaatttg ctatcgtcgc tgctgaatta aagtttttcg gcgtcaaaat aaagcccatg 1808821 ccatgcttta aaatcagttc ctgtttctct ggaagcccga tattcatcat ataaatatta 1808881 tcaacaaaca gtcccggacc gtcaaagcgc ggctttatgt actcgatatc tacaatatcc 1808941 ttcaacacac tgcccgacat aaacttcatg gccagtaaaa aacaaacgac agccgctatg 1809001 actgcagccc agatggataa aaacacatac gcagaggttg tcaaaagcgc tgtaaagatc 1809061 acaatataat ttctgctttc aaacgcaatg gcaatcccct caatatatgt gcttcccctt 1809121 gagacaagtt catacgaatc catttgcgtc aatgtgttcc gctccatgtt tcggacatct 1809181 ctaaattgcg tcgctgccaa tgttaaaaat gtgatggccg taaattcctc ctgcaaaagc 1809241 gccggcataa taattgcacc taaaccagcc gctatcaacc ccagtgcgat gtgaatcact 1809301 ttcccatgaa cataggtcgg atactggcgg taatccgttt tcagcatata aagccttgtc 1809361 gcaattccgg caatgacccc agcaataatc ggatagatgt aatcactcat gacattttgg 1809421 tagctccttt gtttgatctt ttgcttttct gaccaatctg gcttgcgagg tgttcgtatt 1809481 tagatatgcc aaacagcaat atcatccccg cagaacacgc attcagccat tgaaagccgc 1809541 cgacagccat agccccggcc aacttctgga tcacaaatga atacaccagt tcgccttggc 1809601 acatccctag gacaaataag acaagctgct tctcaaaatt cctttcaaca gaagctgtta 1809661 aaagcactat taatataaca gcagcccact caggttttat gatgaaccaa accgggtcat 1809721 ataatgcaaa aagataaaca aacgcatacg cggcaacaag cgtcagatag accatgatgt 1809781 aacgaaaacg atacattccc aaatacccgg catagacaca tccgcaaacg aaaaacatca 1809841 aatatgcagc attcagggaa aaatataaag cgatgtcatg tatgcttaga ataatattag 1809901 ttaaaataaa gacagagacg gcaattcgtc ttttcgtctt ttcaaaaata aatgttgtca 1809961 gaacccacag aaaccacatt gaccaatagt aataaaattg ttccatttta cttcctccat 1810021 attcccagta tggagttcaa gcacattttt taaacaatcg atctcacatt aaggagtatg 1810081 atcatgggaa aagacagaca agagaaaaaa ctcaaagctt caggcagagt cgaatcagat 1810141 cgcgaccagt ccattcacta tgacggagcg acaagccttg aacaaaacgg aagattcaaa 1810201 aagcgaaaat cataatacaa aaagcccaaa ccacatatgg ttttgggctt ttatcattta 1810261 tcgcacacta tagcttgatg tattgacccc tctctctgtg agccaatgat gggtttcacc 1810321 tttgatcaca aggggcgcct tttgtaaatc ggcaattgtt ctggcaccca gcacggtcat 1810381 aatcaacttt aattcctcaa ggatcagctg aatctcctca agcagtcctt cctcaccgct 1810441 gtcagtcagc gcttttaaaa aatgccctgc cattccggtg caagaggccc ccagcgcaat 1810501 tgcctttgcc acgtcaagcg catcttgcag accgccagag gcgatcatgg tgcttgcagg 1810561 aaactcagag cggatttccg ccaaacttgc agctgtcgaa atgccccacg aattaaaaaa 1810621 ggagatttgc cgctgtcttc ggagattttc gattttcgag aaatttgttc ccccgtaacc 1810681 gccaatgtca acagctgcag caccagcttc atacagcttt cctgctgatg ctttgctcat 1810741 accgaagccg acttctttca caatgaccgg tacactgacc cggctgcaaa tttgttcaat 1810801 gcgtttcaat gcgccgctaa agcttctgtc cccttcaggc atcacaattt cctgaatcac 1810861 attgaggtgg atctgcagtg cgtttgctcc aatcatctca acggcttcct ttgcctgagc 1810921 agccgttgcc tcgcttccca ggttggcaaa aatcagcccg tttgggtttt cctttcgaac 1810981 aatttcatag gaaagacgct ctgatggatc ttttaatgct gacatttgcg atcccacagc 1811041 aaggggaatt ccagcctgag aagccgctcg cgcaagcgat ttattaatct catatgtaag 1811101 ttttccgccg ccgccagtca ttgcattgat aaaaatcggc gaactgcttg aaagttcgcc 1811161 gatttttgtg gaaatatcta cttgttctaa tgcaagatcg ggcagactga cgtgaacaaa 1811221 cgtaatatca tcaagacctg tttcccgctt ctggccgatg gacaaggcat gattgatgtg 1811281 ttgtcttttt cgttctgctc gagtcacgtt tatcaccaat tattttagtt tattcagctt 1811341 atctccgatc agatctccaa gctggaagcc agtgcttgtt tcttccttcg cttgatattg 1811401 acggtaatct tcctggtcag ctttaggcgt ttcttcaagt tcacgcatgc ttaatgaaat 1811461 gcgctcctca ttttcattca catcaagaac cttcactttt acagtctgtc cttcttcaag 1811521 gacttcatgc ggcgtgccga tgtgtttatt ggaaatttga gaaatatgaa cgagaccttc 1811581 aacacctgga aggatttcaa caaaggcacc gaagcttaca agacgctgta cagttccttc 1811641 aagcacatcg ccaggcttca ctttttcgcc gatttggttc caaggtccag gcagtgtatc 1811701 tttgatcgat aaagaaatac gttcattatc acggtcaacc gataacactt tcacttttac 1811761 ttcttgtccc tcttcaacaa cgtcagacgg cttctctaca tgagagtggg aaagctgtga 1811821 aatgtgtaca agtccgtcga tgccgccaat atcaacaaac gcgccaaagt cagtcaggcg 1811881 ctgtactttg ccatcaagta cacttccaac ttcaagagac tgaagaagtt cttgtttttt 1811941 attcgcttgt tcactttcaa caacagcacg gtgtgaaagg atcacgcggt ttttatcacg 1812001 gtcaagctct acaacgagca gtgacagtgt ttttccttta tagtcagtga agtcttcaac 1812061 gaaatgtgct tcaacaagtg atgccggaat aaaaccgcga acgccgatat caacgacaag 1812121 gccgcctttc acgacatctt tcacttcagc ttcaaacact tcttttgttt caaatttttt 1812181 ctcaaggtct tcccaagcgc ggtctgcatc aacagcacgt ttagataaaa tcaaagcatc 1812241 gtcttccact tttgttactt tcaggtcaag ctcgtcgtct actttaacaa catccgatgc 1812301 tttctctaca tgaagacttg ataattcact gattggaata ataccggatt gtttgacatt 1812361 gataatttct acatctacat gtttgtcttc tacctttgtc acaatccctt taactacatc 1812421 tccaacctct ggcacttgaa catcaatttg attcatttcc tctgtcattt gaataacctc 1812481 cttggtccaa acctacacag cttaattaaa acggtttgaa agctgaacat ataacatgcc 1812541 cgcttttagc cgaatatgta ttaaagaatc atccaaaaaa gttttttgaa tgatcaataa 1812601 aaagttttat tagtattaac ttctaataaa aggacaggtt tgtcaagcaa taacattcta 1812661 tcttcgttga aaaattcaaa aaaagtggca tttgccatcc tcagcgggac ttttgctcca 1812721 cagcctcgag gattttatca gctacctctt gaatggaaag cgatgtcgtg tcgatttcaa 1812781 gagcgtcttc tgctttacgc agcggagata cttcgcgctc tgaatcaagc ttgtctcttc 1812841 ttgcaatttc ctcaattaat gtttcgtagt tgacatcaaa gccttttttc acattttctt 1812901 cataacggcg tttcgctctc tcttccacag atgccaaaag aaagattttt acttctgcat 1812961 ttggcagcac atgcgtcccg atgtcacgac catccatgac gacgccgcct ttttccccaa 1813021 gctgctgctg gcgtttcacc atttcttctc tgacacttct gtgcttggcc gcaattgaaa 1813081 cttggttgct gatttcatct gttctgatcg cctcagttac atcggtgccg tttacaaaca 1813141 ctttttgtcc atcttttgtt gtaatcagct caatgtctgt ccgctttagc agctcagcca 1813201 gtttttcttc atctgtcaga tcaacgtttt cctgtaaagc cgcgtacgta atcgcccgat 1813261 acatcgctcc tgtatcaata tatatgtacg attttttctc agccacaatt ttggcaacgg 1813321 tgcttttccc cgcagctgcc gggccgtcga ttgcaatcga taatttcttt tccataattc 1813381 ctctccttgc tcttttctcc tctaaggatt gtatcacgaa ctttatgaaa aagggtgaaa 1813441 aattgatgaa taattaatgt ttgaaggttt caatcctatt gttttcctcc attttatcca 1813501 ccccttcata ttgaatcact tttgatacgt atggttcaat atgctgatag tgaaaaagaa 1813561 attggacacc aagtaaaatg atggcctgaa tgaacaataa tttgatcagc agccgttcaa 1813621 atgttttcat tggagcacct ccattacaaa tagtatggaa gtgtttgccg atgtttattc 1813681 cattcgggcc tttcttctct tatttaactg gcgcctgatg cagtattgaa gcaaagcctg 1813741 ctggtcacct gctgcaattt ctgaatactc taaagtcatt tttcgttttt ctgacttggg 1813801 gtcattaaag attcgtctga caactgcttc tgtttctatt tgacgtgtgt gctcctcttc 1813861 aggaagacgg atgatcaggc gcaatgattc ccccgattga aaagaaaggc catcagctaa 1813921 aaccacggcg atgccgcctg cactgatgtt ataggatagt gtgcggatct cttcttcatt 1813981 tcccggctga atttgcacat ctaataccgc atcagttctt acatattggc ggcgctggat 1814041 tcttttcatt ttttcacggg gaggcatttc aagacagatc atttgaagtt tgtccttcac 1814101 tttacctttt atacggctta taaagcgata aggaacttcg tcttttccca caaactctac 1814161 cgttacttcc atatcgttat gtaaaatcac agttcgccct gtaactacat caacaggata 1814221 cgcgatcaaa agttcattgt tttcgatgct gaccgccttg ctttttgcct ttttcaattc 1814281 attttcttct atatattcta aaagtacatt ttctccaatc tctatcattg acttcactct 1814341 ttcgcattca atatactcac gtttttatta aagcacgtaa tgaaaaaaag gaaaagacat 1814401 ttagtccttt cctcctgttt ttataggtct ttatatatag gttctgcatt ttttagtttt 1814461 tcaacctttt cttccgatcc gtctttggca ttgatataca ttctgaatgt gtcattttca 1814521 attgtcccaa gcatttcgta gcataacact tcttgaccta gttcatttgt aatcaaagcg 1814581 agccttgttt ctctcacttg tacattttta tttaatttag actttgcctc tgcttcagta 1814641 attgcaggct taggtatggt tctttttctg tgagatgtga ggaagtctct tgctgaaaag 1814701 ccgacaacct caccgtcatc caaggccact ttcatacgaa ttgcctcggg gtacatccgg 1814761 actttatttt caacaggaac atatgaaaat acaccgattt tatcatattg ggcactttca 1814821 tcaatttcca aatcatctgt ttcaaatccg tttttcttta aaaatgcaag cgctcggttc 1814881 gatccgtcat ttaaactgat tttctgatct ttcacttctc tgttttggat caagtatacc 1814941 ggatgcccgc ccttcttcgt aatatccata taaatcactg ctttatggtc tgggtctttc 1815001 atgctgatgc tatatacatc gcgatttgtt ttttttccgc tctttaccac tttaattgaa 1815061 taattgtcat ctggggcaaa gcgctcagca atttgttttg cttcctgttc ggaaatttgt 1815121 tttcccttca gatggctgaa gcctttctct tcttttttcg tactggtgaa actcgggcca 1815181 agatcagtgc cagtggagaa tgcaccaaca tttttttcga ctgttttaaa gctgttgata 1815241 atcgtattat cactttgttt ttcgtcagaa gccagagcca tttctacgtc catccagcga 1815301 aggtttttgc tcatgacaag gtgctgaaca tgacgcaatt cattttgtat atcttcggac 1815361 tgctgatata gcttatttag tgatgtatac tcgtttttat caagcggctt ttggtccaaa 1815421 tctctgactg acgttttata gctgaaatcg ccgatctttg ataatagctc ttcagtttta 1815481 ttaaacggca ttaatgtaag cggcagctga ctgacgctgt tatgagcttc tgatgtaatc 1815541 ctccacacat cgatcaatgc aggcgacagt gatttttggc tgttcatggc aagtgttgtt 1815601 ccgattttat catgaagctg atccacctga taggtaagct catgaaacgc ccgctgatag 1815661 ttattttcag catgaagaag aactgcgtct ttttcctggt gttctttgta tccccagtag 1815721 cctgtaccga ctattgcaat accaagcacg gcgattaaaa ttcctctgat catttatcac 1815781 acctcttttt atgctttctc atatctgcta ctcacagaaa atgtgtttac cgattctttt 1815841 aatctgcgga cgcccccaaa tccacggact tgtagccgta tccggattaa agtagtaaag 1815901 tgcttcctct gatgggtccc agccattgat ggcatccagc actgcttctc gtgccgtttc 1815961 attcggctgc atgtaaattt gtccgtcggc tactgctgtg aaggcaagcg gctcaaaaat 1816021 aacccccgct actgaatttg gaaataacgg gctgttcaaa cggtttaaaa tgactgctgc 1816081 aatagcaacc tgcccctcgt acggctcgcc ccgggcttcg ccataaaccg cttgagcaag 1816141 cagcctgata tcgttgttgg aaaatccacc aggcatgttc gctgctaccg catcctgttt 1816201 tcttgctttt gctggtgtat tgttttgctg tttattcgca ttcgctttag gcttctgcgt 1816261 tgttttttcc gcaggctgtt tctgccgtgc ttctgcttgt tgtcttgcct tttgtgttgc 1816321 tgcttttgat ggtttcgtct gatactttag cggaattttt ccgtaatgcg tgaatgtatt 1816381 ccctttattg agctgttcca tgacatattc acgatagtat tttgatttac atattaaggt 1816441 ttgctttgtt ttagctccta caaggccgtc aacctctttt aacccgaatt gatcctgaaa 1816501 atttcgaact gcccagtacg tcccccatcc ataaaccccg tcaatttttc cgttataata 1816561 tccgttgtat tgaagacgcg cctgaagctc gaccacatca tcccctgttg cccctctttg 1816621 aatgacctga ttcgaaaagg cagagatcgt ttcagtatta ataaacgtcg ttattgtaaa 1816681 ggaaaaaagg atgagacatg ccataatcga tcctttggac ttcatctttt caagcctcct 1816741 actgcaaatt tttaagtgta atcgtatttt ctgtaacgag gttattttta tacactcttt 1816801 ccttgttatc cctcagaaca taaaaactgc acacaaaaaa gccgcacggt tgctgtgcgg 1816861 cttctatact tgcatcatat taacggaacg ggcttttttc gctttacgca aaccaaacca 1816921 ccataaaaat accataaatg gaagcatata ataaatccaa ttgctaagcg ctgttaggat 1816981 aaaatcatat gatccatgca aaagggatgg gacaactaaa gaaagagtaa gccactttac 1817041 acgcgcctta tcagcggaaa aacgggcttt tccaaggtaa aatcccatta taacgccaat 1817101 caaggcatgg catgaaacag gcagcagcgc cctgacaaac gcatgctcca cgccgtggcc 1817161 aattaaataa agaatatttt cgagggttgc aaaaccgagt gatacacttg caccgtacac 1817221 aatcccgtca taatgctcat caaagtgggc gtgcgggtaa acactgatca tcagtataaa 1817281 ccattttaat gattcctcca aaaaccccga agataaaaaa gaaacgaaaa agcttccgcc 1817341 tcctacattc tctttttcaa gtacatactg gataaacatg atgggaaata caagaacaac 1817401 cccgagaaaa aacgaccgta gcaccatatg tacaggttca ttatcatact gatcttttaa 1817461 ataaaaataa cttaataacg cgatgccggg ggcaattcct gcagagatga ttgcaaacat 1817521 caggcaacct ctttccttta tattcctaca tctatcctac catgttgttt aaaattttac 1817581 atctgtctgc acttaaaaaa acaaaaagag catacgaatg catcatatgc tcctcatctt 1817641 taatggtttt ctcttttggc gatttccgct gcgatatgcc ccccgtgaaa cctgccgttt 1817701 tcaataaata tttcatttgc attgtttccc gcagcaataa caccggcaat aaagacacct 1817761 tcaacgttcg tttccatcgt ttcttcgttg aaaaatggac gccctgtttc tttatcaatt 1817821 tcaacaccaa ttttttcaag aaattgatga tcgggatgat agcctgtcat ggcaaataca 1817881 aaatcatttt taatggtaat gagttctttc tctccggagc gaaacacaac ttcattctcg 1817941 gtgatttttt cgacacaagc tccaaattcc atacggattg taccgtttct gacgagagct 1818001 tcaaattccg gcagaatcca cggcttaatg ctcggagaat actcattgcc cctatataaa 1818061 actgtgacac gcgccccaga tttcacgagt tcaagggcgg cgtccacgct tgaatttttc 1818121 ccgccgatga caacaacatc tttatcaaaa tacgggtggc cttctttaaa ataatgaaat 1818181 actttcggca aatcctcacc gggtacgccc atatagtttg gatgatcata atagcctgtg 1818241 gcgatgatac aatatggcgt cgtgtaggtc tcttttgacg tctcaataac gaatgtgtta 1818301 ttttgcgttt tcgtcacttt acgcaccatt tcaaacgcat taacacggat gtttttccgt 1818361 ttaacgactt cccggtaata cgataaagcc tgaattctga caggcttcct gttctctgta 1818421 ataaatgcca catctccgat ttcgagcttt tcacttgaac tgaaaaaggt ttgatgcgtc 1818481 gggtaattgt aaatactgtt aacgacattg cctttttcga tgacgagggc atcaatgcca 1818541 atttgtttta ggtgaatggc agcagatagt ccacaaggtc ctccgcctat aataattgct 1818601 ttttcttgaa tcatttctgt caactcctgc gattggcatt tcacttcata ttttctattt 1818661 ccgaataaaa aaatctccta ttttatcata ggagattttt tatttttatg caaatcatca 1818721 acttatatcc agcctctaaa acgcgaagct tcagccattt tgcgaacgcc gaccatatat 1818781 gcagcgagcc tcatgtcaat tcttcggttg ttagccattt cgtaaatatt gttaaatgat 1818841 ttgaccatca ttttttctaa tttttcttct acctcttctt cactccagta gaagccttgg 1818901 ttattctgaa cccattcaaa ataagaaact gttacgccac cggcacttgc cagcacgtct 1818961 ggtacaagca gaatgtcccg gtctgaaaga atttttgttc cttcaagcgt tgttggtccg 1819021 ttcgctgctt caacgacaat tttagcccgg atattatggg cattttcttc tgtaatttga 1819081 ttttcaatcg cagcaggaac gagaatatca caatccagct ccagcagctc ttggttggta 1819141 atggtatcgt tgaaaagctt tgttacggta ccgaagctgt cgcgtcggtc gagtaaataa 1819201 tcgatatcaa ggccttccgg atcataaagt ccgccatacg catctgagat gccgacaact 1819261 tttgcccccg catcatgcat aaattttgcc aaatagcttc ccgcgtttcc gaagccttgg 1819321 acaacgacac gcgcaccttt aatatcgatg cctctcttct tagccgcttc tttaatacag 1819381 atggtaacac cttttgctgt cgcagattct ctcccgtgag atccgccaag cacaagcggt 1819441 ttgcctgtaa taaatccagg cgaattaaat tcatcaattc ttgaatactc atccatcatc 1819501 caagccatga tttgtgagtt tgtaaataca tccggtgccg gcacgtcttt tgtcgggccg 1819561 acaatttggc tgatcgctct gacataccct ctgctcagac gctccagctc tctaaacgac 1819621 atatcccttg gatcacaaac aattccgcct ttaccaccgc catatggaag atcaattatg 1819681 ccgcatttta aactcatcca aattgaaagc gccttcaccg ccttcacctc tttttctgtt 1819741 acgttcgggt gaaaacgtat cccgcctttc gttggaccga cagagtcatt gtgctgcgca 1819801 cgatatcctg tgaaaatctt tactgaaccg tcgtccatac gaacaggtat ttttaccgtt 1819861 aataatctca tcggctcttt taacaattcg tatacctctt cgggatatcc caatttttcc 1819921 agagccttat gtattacggt ttgggttgat tttaatacat caagtttgtc ctcttctgta 1819981 tgaccggtgt ttcgatcggc tgccatttga gttaacctcc tagaatcttc tgtttctcac 1820041 atgctccctt tcagagaata gtatacacct tcatatgatc tgtgcataga ataaacgtta 1820101 tgtttttcca tgttttttaa cgaaaaaaaa ctgctgaaat cagcagtttt ccgttgcatt 1820161 cttatgaaaa atgagtttgt atcgtttcta cggcattacc gtccataatg agcttaccat 1820221 actcttgcag gcgataaatc gttaaagttg tcggattgcc gtattcagcc agaaccgcca 1820281 caaccccttc agccgtatgt gaccctagat cttcaaggct taaaaagtac tgcccgtcat 1820341 agtggtagac agttccccct gtgataccga ttcgctgtaa gctttctgaa agctgaatga 1820401 tatcttcaaa ggaatggaat tgatatatga tgtccgcgct ttcatcaagc ttgacttgca 1820461 tttcgatgta atcatcatca tactcatcgt cttctgaatc ggcgtcttgg ttctttgtta 1820521 caatcacgac catcccttgt gcttggagag aatacacttc cactgcaatc ggtccattcg 1820581 cttcaaagcc gagctctgta tttgcttcat tcatcatatc tttaaataac tggtggactt 1820641 taaatgagtc cttccagagg tcttcttttg tcaatccccg gtctgtcaaa tcatcgaggg 1820701 ttaaaaagat tttgatctta ttataattca gacgctcaag ccgcataacg ttccctcctg 1820761 cctctacttg cacacaaatc atataacaca ttatatgaga tgatgagtca taggttctta 1820821 attgttatca gtttacactg agttcactag taagacaagc acaatgcagt ttttattgcc 1820881 atacggattt ttgcttttta gaagttattc tggcccgcaa agagtcacaa tgtgagtttc 1820941 aggctcagca cctaaacgaa gaggcacttt tgtcgtgccg tagccgttgc tgatcagata 1821001 tgccgcgttt ttaacaatac ctgttttccc cagttcataa ggaccgaatt ttccaaacct 1821061 gatctggcct ccatgggtat gtccgctgag tatcacatca ataccgtcat cttcattgat 1821121 ttgttcatga atctccggat tatggcaaac cagaatattc agctggcttt catcaagttc 1821181 tttgatggct tcctcataat gatccatctc catcctgata tcatcaaccc ccgcaatcgc 1821241 aatcgtatgc ccattgtatg aaaacgggac tgactcattt ctcagagtga tgacgccgtg 1821301 cgctttaaat atggaataca gcttatgctg cctgacttca taatcattat tcccccacac 1821361 aaacacgata gggaccccga aatgtacgag ccttttgatg ttttcctcga ttctcgcact 1821421 gggcaccccg ccctcagcta aatcaccgcc gattataacc aagtgggggg catggcttcg 1821481 cgctttttct aaaaggtctt gatcgatgag acgtttgtga atgtctgaaa taaaaaagat 1821541 tgtcagaggc ggcttgccct tcatctttga taaaggaaac gtatgtgtct tcaaatgatt 1821601 gccttttgct gttgcataca tttttgccgt cattgccgct gccgcaacag ttagtacacc 1821661 ggcaattttc actgatagct tcataaaaaa ctctccattc tttttagaac ttatcaataa 1821721 gacggacaat aaaaaaagac gtttctatcg tttgagaaaa cgccccattt tatttacttt 1821781 caaaatatag attaatgtca tatttgtgct tcatcatatg aaaaacagac tctctcgcct 1821841 tccatttatc gggctgcggc cagagatcag tgcttttctg aataatttca catctcagtt 1821901 tatggaaatc agtctcggat ttttcttcct ttttcttgaa ataatatgaa gtgcagtagg 1821961 caaaagcggt tgccagcatc caaaataaat aaaaggtatg gctaagtatt tcttgaagta 1822021 taagctgagg ctccgggctt ttgatcatga tcataacaca taataagcct aggcagataa 1822081 gtgaagccca tcgccatctg cggcattgtg ctgcataatt ttcgaatttt tgttttcgtt 1822141 ttaccagcgc ttggagcatc tgtttggtcg gcgcgtctgt aaactgatcc agctgattcc 1822201 ataaggattc catacgcttc acaccttgtc cattttcatt gctacaatat atgaacgtaa 1822261 aataaaaata ataccctatt catccattaa agggatgtcc aaaacttgtc cggtgtaaac 1822321 atcatttcca ttcagatgat tatatgctcg aattttttct tctcctgtcc ggcttttata 1822381 atacttcatg gaaatgcggt atagcgtttc tttcttttgg acggtgtgct tgacaacgcg 1822441 attcggcaca ttttgaactg gctcagctgg ctgttcttgc tgttgtactg ttgattggga 1822501 agaggaagca gccgcggcgg ttgcttcctc cttatttggc gagtcttctt tttccgctac 1822561 agcagtctgt ttcttatcag cagctgtttg ctcttttggc ttggaatctt ctggctcttt 1822621 ttttgactcc ttctgcagtg cggtttcttt agtgtctgcg gtatcgtttt tatcctctga 1822681 tttcgggaca acctcatatt tgctttggct gctgtcaata aaaacatctt cataatcgtc 1822741 atgattatcc gggtggctct ttagataaaa taaggtgact aaaacgataa ccggcacaaa 1822801 tacaaatatt actgcgagta ctgtgaataa tggcgttttt gttttgcctt gctttttttt 1822861 ctgttctctt tgatttttta cagattgtct tgtcggaagg ctttctccat catcgacata 1822921 atcgtccgcc aatgcggcgt tttgatcttc ataaagattc tgggcttttc ttctctctac 1822981 tctcgacatg ttcgtcatgt ttatccctcc tcacatgttc aaaacgaatc tgacaggcaa 1823041 acacggcatc aatgataaaa tgcgccgtca tcggaacaaa taagttgccg gtccattcat 1823101 acatcagacc gagcaaaaag ctgattgctg tcaccataat aaataacagc cattttgaca 1823161 aataccgaaa gtgcagagcg gcaaatataa ggctggccgt ccataaaccg atatgagtct 1823221 gcagcactcc tctgaataac atttcttccg cgaaagcaat cagaagcgtt aaaaatataa 1823281 tatgagggat tgacctctta ctgaatattt ttttattgat tccgccgtca tcatataaat 1823341 gagacggaaa ccatttcatt actgccatat cggctaaaat aacaataaca gctatagaaa 1823401 caccatacca gatgattcgc atatcgcgaa tgtcccagag ctttaatacg tcccgtacat 1823461 cctcaaaaaa gaacagtcct gctgcagcag cggcaaagat gatgagtagc tgcgtcaaat 1823521 ataactgctt cagcatatca tggtcagtca tatgctgaat ataatctttt tgctgtttca 1823581 gttcagctca cctacagtct gcaagctgaa tatccggtgc aattccgaac tccagctgtc 1823641 taatggcgcc attttactcc gttccccttt ttgttcatac aaggataaat caaaaccgca 1823701 atgtgaacag cacgggaggt ttccgtcatc aggctcgtat gattcatcaa agtaggttaa 1823761 cagtgcctgc cttaaacagc cgtcacgctg aagcaaaaat gatacacggt gcattttttc 1823821 cagcttcagc tccatgcgat atgaaatttc tttcttcatc agttcaactg atgtttttcc 1823881 ctgcataaag agatgaatca tcatacgggc ctgtgtctct ccgacgccat actgaagtaa 1823941 tacgtcacgc agccttctct catcccgctc ctccgtcttc tctagcacac ggattacgtc 1824001 ggcgatttct tcagctgtga cactctccat ctggataatt tgttcctgca attcaaaatc 1824061 ccctggcgcc cgcagcaaaa tgctgacact cggctttccg tcgcgtcccg ctctgccgat 1824121 ttcctgcata aaagcttctg ccgtctgcgg gagatgaaaa tgaatcacat atctgatatc 1824181 aggtttatcg acacccattc caaacgcatt cgtacaacat atcacatcaa gctggttatg 1824241 aataaactgc tgctgaatta aaatcctgtc ccctgactcc aaaccgccat ggtaaaagtc 1824301 ggctctgctg ctcgttttgc ttttaatttc acccgctaat tccttagccc atttccgtgt 1824361 tggacaataa acaattcccg gaccttgcag gttttcaacc agctgaatga ccctatctat 1824421 tttttcggca gtatccgccg cattttcaac cctcagtgcg atgtttgggc ggttgactga 1824481 gttgagatgg cgtacagcat gctgcagctc cagcaggttc atgacatctt gcagcgtttc 1824541 ctttgtagcc gtggcggtca atgccagaac gggtgggtgt ccaagttttt ttctcagctg 1824601 tccgagcttt gaataatcag gcctgaagtc gtgtccccat tcagaaatac aatgcgcttc 1824661 gtcaataaca aataggctaa tcggaacgct tttcaatttt tccaatacat atggagactg 1824721 taaagcttca ggagacaagt acaaaaattt atatcgatga atatgttcta aaacaaattg 1824781 tctttcctgc ctgttaagca tgctgttcaa agctgcagca cgcttttccc cccgggcttt 1824841 gagctgctgc acctgatcct ccattaaaga aagcagtgga gaaacgatta ataccatgcc 1824901 atcaagcata taaccaggca gctggtagca aagcgatttc cctcccccag tcgggagcat 1824961 tgcaatggta tccttcccgc tgagtatgct ttcaataatg tcctgctgcc cttttttaaa 1825021 ggaagtaaaa ccaaaaaact gatataacgt ttgctgtaat ttagtcatat tgctgcacct 1825081 gctttgtcaa tgccagtctg atttgaaagt agctgaaccg ctgttccagc ccgtcgcgaa 1825141 tttgtttgat tttattcgtc cgcatccgtt tggcaaactc tgcgatttga agctggtctt 1825201 ctgctgatac atagtcatta atcataaacg caggctcatg gagagaaatc tcgacaatgt 1825261 ggtcttcaat cgtcgctgtt ttcagctttc tgatttcagc aattcgctgt atcggaaacc 1825321 cttgtttgac catctgccat gttttcctcg tcgactctgt cagggcatta tctaagtgca 1825381 catcagaaag gagatccttt aacaaagcat cttcacactc cggaagagaa tgaataaaat 1825441 aatgtaccga agcccaaaac atgatataga cataccattc gtcttctttc agcgtatcag 1825501 caagctgcct gctcgtataa ccgatccgat ggtgcgaggt taaggagtag acaaaaattt 1825561 gcgctgcttt gttttcaatc tttttcaaat gcgcctcaag catggcaaaa aggctttttg 1825621 ccatctctat atgatccgta tgccgggaca ggtatttctt tacccagtga agtgtcttat 1825681 gatcctttgt gacagggata tactgcctgc tcccttgctg tttatgggat aggacctgca 1825741 caagcagcga aagccttttc caaagcacgc cggcagcctg ctgataatga gcgccgtgac 1825801 aatgaacggg ccaaggccgc tcgctaaggg catgtctcaa aactgctgcg ccgctggctg 1825861 tcactttgta tgtatctgat tcagacattg gcgcgagata tgaatgcttt tcaagcttgt 1825921 caagcgacgc agaaatatcg cttctcgaac attttgccgc cattccaaag tattttgcag 1825981 tctgaaataa gccggcatct tgaatggtct gtgacgatct cttgcctttg aataggtgaa 1826041 aaacagcgct tcccgaccgt tccccgttta ttttgcaaag acaatcgaga accataatat 1826101 cgaagtaatt taatgacaac ctatccacct acattcttcc tgacaaaaat cgttgatttg 1826161 ctctttttat tttaacagat ttcaaacaga aatcgacgtt taaagtcatc attaaggggg 1826221 atgttatgta gataacccct tatgtgataa gcattctcaa tcatttttct gttgaaatgt 1826281 ggcagcaaca tcattacaat aagtaagagg aataggtgtt aaattgatta aatataaaga 1826341 ttgatccatt tgttccacca agaacaatct gggaggtttt attcatggca aagtacacaa 1826401 tcgtagacaa agatacatgt attgcatgcg gcgcttgcgg agctgctgca ccagacattt 1826461 acgattacga tgatgaaggc atcgcgttcg taacgcttga tgaaaacaaa ggtgttgtcg 1826521 aagttcctga ggtactggaa gaagatatga ttgacgcatt tgaaggatgc cctactgatt 1826581 ccatcaaagt ggcggatgag ccatttgaag gcgacccgct taaatttgaa tagaagtaac 1826641 taaaaaaagc tcccgaacgg gagctttttt atttaatgga tatgtgcact tcgctgctgc 1826701 tcaatccatg gcttaagctt gataaaaatt agtgagaata caaccgtaat tacaatacct 1826761 tttatcatgt taaacggcag gatacctgcg acgactgctg tttttagcgc gctgtcggat 1826821 aatgccggtg aatgtaaaaa ccacgtgtat gccggaagaa tcagaacata atttaaaata 1826881 ctcattaaaa tggtcatcgc tgcagttccc aaaagcaggc tgacagccaa gccctttgct 1826941 gagttgagtt ttttaaataa gaaagcagtc ggtaatataa agagtgttcc tgcaataaaa 1827001 ttcgcaactt gccctacagg aactccggcc atgcttccct gaatgatata ctgaagaaca 1827061 ttttttatcg cttctacggc aatacccgcc aaaggtccgt aaatcagaat ggcaataatt 1827121 gcgggaacgt cgctaaaatc gatttttaaa taatccggaa gacccggaaa cgggaaattt 1827181 aacagcatca aaacaaatgc aatgctgctc agcatgctga ccacaactaa tttttttact 1827241 ttcacttcat tctctccttt tcgatcacat cttactcgaa aacggaaagg ttcttttcca 1827301 gccaataaaa aaaccgcttc atatataaaa gcggggtttc gaaaattagg ctaggcaaag 1827361 aaacgtttga aaaattcaat ttcaaaacgc ttatgaacct ccatcttctc ccatccagac 1827421 tgtactgtcg gctccggaat ctcaccgaat cctgctgtaa agacagctcg cgggcttaga 1827481 gccattggct catcaccgcc ggtagggaat ttcaccctgc cccgaagatt gatcatatga 1827541 aatttaatta cattataaac gataactggt tggctgtata gagaattgct tcaaattaaa 1827601 tatattacct gcaagctgtc agatcattga tttattaggc tttactttta tcctttactg 1827661 cgtcaataca cgttgacact cttttgagaa tatgttaaat tatcagatat ttagtttgtc 1827721 aatttaggag gaaatctaac gatgtttcga gtattggtct cagacaaaat gagcaacgac 1827781 ggtttacagc cacttattga atcagacttt attgaaatcg ttcaaaaaaa cgtagcagat 1827841 gcagaagatg aattacatac ttttgatgct cttttggtgc gaagcgcgac aaaagtaaca 1827901 gaagaccttt tcaacaaaat gacttcttta aaaattgtcg gaagagccgg tgtcggtgtc 1827961 gataatatcg atattgatga ggctacgaaa cacggggtaa tcgtgatcaa tgctccgaac 1828021 ggcaacacca tttcgacagc tgagcataca tttgcaatga tctcttcttt aatgagacac 1828081 attccgcagg ctaatatctc agtgaaatcc agagagtgga accgcacagc ttatgtcggt 1828141 tcagagcttt atggaaaaac gcttggtatt gtaggattag gccgaatcgg aagtgaaatt 1828201 gcacagcgtg cgagagcgtt cggtatgact gtgcacgttt ttgatccttt cttaacggaa 1828261 gaaagagcga aaaaaatcgg cgtaaacagc cgtacatttg aagaagtgct tgaaagtgcg 1828321 gatatcatta ccgttcacac gcctttaaca aaagaaacaa aaggcttatt gaataaagaa 1828381 acgattgcaa aaacgaaaaa aggcgttcgc ttaattaact gtgcgcgagg cggaattatc 1828441 gatgaagcag cacttctcga agctttggaa aacgggcatg ttgcgggagc agcgcttgac 1828501 gttttcgaag tcgaaccgcc agttgacaac aaacttgttg atcatccatt agtcattgcc 1828561 actcctcact tgggagcatc aacgaaagaa gcacagctca atgtcgccgc ccaagtgtca 1828621 gaagaagttc tgcagttcgc aaaaggcctg cctgtcatgt cagctatcaa cctgcctgcc 1828681 atgacaaaag atgaatttgc taaaattaag ccttaccatc aaattgcagg aaaaattggc 1828741 agccttgtat cacagtgcat gaaagaacca gtacaggatg ttgccattca atatgaaggc 1828801 acaattgcta aacttgaaac atcgttcatt acaaaagccc ttctgtcagg ctttttaaaa 1828861 ccgcgcgtag actctactgt taatgaggtc aatgccgggg gtgtcgcaaa agaacgcggc 1828921 attagcttca gtgaaaaaat ttcctcttct gaatctggat acgataactg catcagcgta 1828981 aaagtgacag gagaccgcag cacctttact gtaacggcta cgtatattcc tcatttcgga 1829041 gaacgaattg tcgagatcaa tggatttaat attgattttt atccgactgg tcacttggtg 1829101 tatatccagc atcaagatac aacaggtgtc atcggccgag taggacgtat tctcggagat 1829161 aatgatatta acattgcaac tatgcaggtt ggccgtaagg aaaaaggcgg agaagccatc 1829221 atgatgcttt cctttgacag acatctggaa gataaaattg tgaaagaact aacaaatgtc 1829281 cctgatattg tgtctgtgaa gctcattgat ctgccataat taaaaaaact caagctatat 1829341 agcttgagtt tttttattgt tctatccccg tgtgttttta tgcaaaatat ctaagacact 1829401 ccttagctca gaaacaggaa tttggcctgg tgcggacgcc tcttctccag ctccaaaagt 1829461 acaagccgat ccaaaaacct caccgctcag cctgctgatg agccctgttg cagccattga 1829521 cattgtaata atggggcggt ctgcatatat tgttttcatt gtatacgtcg catcaagcag 1829581 tgttaggaga tctccagtat cattcggcat gacagccatt tttggaatat gcgcgcctaa 1829641 gtcctgcatt tttcgaagtc tggaaataat ttcatctttt acaggtgttt tttcaaagtc 1829701 gtgatttgac atcaccacat agacgttgtt ttcttccgcc agcgatacta acgcttttac 1829761 atttgcatct cctgaaaata attcgatgtc tatcagatcg atgtcttttg tttggattgc 1829821 cgattccagc aaagcaagat aggagctttc gtccatctcc atgctcccgc cctctttgtg 1829881 ggttctgaat gtaaatagaa atagcttgtc ttctaaagat ttacgaagct tagaaatgag 1829941 ctttgtgacc gcttctctgt cattcgcttt ttcaaatacg tcgactctcc attcaacaat 1830001 gtccggattc agtaatttta ctgcctctgc ttcattcaga atttgttttt ccgtctttcc 1830061 catcagcgga atgatgattt tcggcatccc ttccccgatg gaaactcctt taatcgttaa 1830121 cacgttcact cgtctcaaat cctttcaatc tttaccttgt tttattatac acgtacaact 1830181 tttttttgaa aatttctatt atatgaatag caactaaaaa agagccttaa agggctcttt 1830241 ttagtttaag gaaatcggat ttggagcagc tggcaccgga attgcatctg atatgtcata 1830301 tttgccgatt tttttcgttc tggtttccgt aaaggtcact tctgtgaagc caaactcttt 1830361 tgcagtcaaa agtagtccct caatcattaa aataccggca atagaatcat caacttctga 1830421 ctcctttgaa aagcggatat ataagtgttt ctgtttcttc gttacagatt ggacagcacc 1830481 cgcttgaata agaggtgtcg tatcttcttg gctgctcgat tccatttcct taatcgcttc 1830541 ttttactgta tcaaaagaat gatttgacgg aacgagaaag tcttgtcctt gtttattttg 1830601 gtacaagtag taggatcgtt ttgactgttt gggaatcgaa atttccgtaa aagtgccata 1830661 tgagccaatc cgaaccccag tctcattttg atccgataaa aatttgactt tttcataagg 1830721 actccatttt aaggattctt taagcaattt ttttaacagt gtatcatctt ttatagaaaa 1830781 tgccgtagct ggctgatgga ctcgtatact taattccttc tgctttggtt tttcctttat 1830841 ttctacttca tctatgaagg ttggaattgt aatggcatga tcaaggatgc ccaattcact 1830901 actttcaaac agcatatcct ggatcgtttg gtctgcattt gttttttgaa tgctgacggg 1830961 tatgattgca gatgtatcgg catcagcaac cgctacagtg atgtaattgt cttgttcctt 1831021 ttcaggaacg acaaacgatg tctgatccaa ggacgatgca gcttttgggc tgtcttctgt 1831081 ctcagttttc gttactgcgt tctcttggga cgcttctttt tgttgaggct gtgcctgatc 1831141 aaagaaatga ggagaaataa tgaaggcgat ataaaccgca attgcagcgg cacacgcggg 1831201 gccaatccac ctgacagcgg gcttattttt acgctttgcc atcgtcagcc gcttgtaaat 1831261 atcctgaggc gaacgatggt ctttaactgc cggaagttga cttaacaact cctttatctg 1831321 ttcttcgttc cattctgact tcatcatcca ttagctcctc cctcaaaagc tccatatgtt 1831381 tccgaagtac tttgagccct ctgtgttggg tcgtttttac tttgctttcc gagaagcgca 1831441 gagccttggc tgtttcctgt attgaatatc cctgaataaa ccgcaagata atcacagctc 1831501 tttgatcgat tgtacattga tcaagcgcag cataaatttc ccggacattt tcatgttgaa 1831561 ccgcaagttc gtccggcagc aattgctgat ccctgacatc ctgtgtatcc cagtcaaatg 1831621 taccgagtat acgctgtctg attgtttgct gtttacggaa ccagtctatc gcaacatggc 1831681 gtgcgataga caaaagccat gttttttcac tgcttcttcc ttcaaacgta tgataagaat 1831741 ttaatacccg gatataaacc tcttgaagaa ggtcttctgt ctggttttta tcctttacca 1831801 tataaaataa aaattggtac aaatcttgat gatatgtatc atataataat tgaaaggttt 1831861 cttccatttg aaacccctcc gttcactttt ttgtcgtatg aatagcttga aaagttacat 1831921 tacaactata ttacgagtaa ctggaatttg gaagggaatt tatattaaca tatccttaaa 1831981 ttttattaat gttggctatt aaaaaaacac ccgctcagtc agcgggtgtt tcttatggaa 1832041 caagattctt cggcaaattc agactcgatt ttaccgtttt gtcggaatat aaaaagaaaa 1832101 tgttgttcct ttatctattc ggctgtgcac agtaattgat ccgttgtggg cttccacgat 1832161 atttttaacg atagccagcc ctaacccggt tcctgctctg ccccttgtcc gcgctttatc 1832221 tgccttataa aaccgctcaa agataaatgg cagatcttct tccggtatgc cagacccgga 1832281 gtctttgata tcaattttca atccatcctt cacagaatgg actgaaatgg agacactgcc 1832341 gccggctgaa gtatgccgca gcgcgttatc aatcaaattg gtaaatacct gctccatctt 1832401 gtcttcatca aacataaatt cctcttctgt gagagaaatg tcatgatcta aagcaatatt 1832461 tttttctttc gcaacaccgg aaaacttccg aatgatcttt tctaaaaact cattcacatt 1832521 gattttttca taatgtaagc ctgtatggcc tgattccatt cgggctaaat caagcaaatc 1832581 attaactaaa cggcccattc ggagcgattc gtcataaatg atttgggcaa tttctttccg 1832641 gtcttcttca gagcttgcaa tgtcatcgac aattgcttca ctgtatccct gaagcatgga 1832701 gatcggtgtt ctcagctcat gactgacatt tgcgataaag tcctcccgca gcttatcaag 1832761 gcggcgttct tctgtcatgt cacgcagtac ggcaaccgct cctctgacgt gcgattccgc 1832821 ataaagcggc gacatcaaaa gcacccatga tctgccttga agcgtcatct caatcatttg 1832881 ttctttttca gtgctgacag cgttttgaaa cagctctttt gcttcaggcg gaagattgtc 1832941 gccttctttg atattcatgt tctgttcata ataccaagcc tgaagaaaac gttcagccgg 1833001 cgggttggtc acaagaatcg taccgtcaat attaatggta ataaccccgt cagccatact 1833061 gctcaaaatg ttagaaagct gctctttttc ttgattgagc gcattgatat gaaagttaag 1833121 ctgccggccc atttgattaa aagcggtcgc cagttcaccg atttcatcct gagttaaaat 1833181 cgggattttt gtatcgaact tgcccttcgc caaatcctgc gcgccttctc tcatttttcg 1833241 gagagggtac gtgaccctgc ttgataaaaa gaatgcgaaa aatgtggtca gcacaatcgc 1833301 aattccagcg gcaagaaaaa tatagcgggt cgtatgtttt gttgtatctt taacggcaag 1833361 caaagactgg gataaaaaga ccatgccttt ctttccgtct ttttcatacg ggacacctac 1833421 aatcaggcgt tcattatccg tgtctgtatc gctcagtccc gtccgtttgc ttactttttt 1833481 atggtctttg agagctttat ttaagtcttt gtcatgctgt atttgctcaa ccgtaataga 1833541 cgacaggcga tttttatcat tcggagaata ccagtggttc ttctcatcct ggatgatggc 1833601 aatgcttgtt aagttatcag cgagttccca agtgattgac cttgccagtg cctggtcctc 1833661 gtgattttct aggatgacag caactttatt cgcaagctgt gttaaatcat tctcagcttc 1833721 ttccacatgg tagttttcaa taaactccag caaaagaacc gttaaaatga acaatacgat 1833781 caagacgagt gaaaggatcg taaaccacag cttgcctact acgcttttcc aaaatttcat 1833841 tcagcgccga cctcaaattt ataacctaca ccccatacgg tgacaatttt tttcgcagct 1833901 tccggagata ccttgttcag cttctctctc aagcgtttga cgtgagtgtc cactgtccgt 1833961 aaatcaccaa aaaactcata ttgccacact tctttcagaa gcttttcccg atcatacacc 1834021 ttgtcaggcg ttttcgctaa gaaatataga agctcatact cttttggcgt caggctcact 1834081 tctgttccat cagctgttac gcggtgagca tcatggtcta ttgacagatg tgaaaacacg 1834141 agcacatttt tcgtcggtgt attggcattg aaataagagg tttgggatgc tcttctcaaa 1834201 agggccttta cacgcagcac gacttctctc gggctgaacg gcttaacaat ataatcatct 1834261 gttcccgctt caaacccctg cacccggttt gcttcttctc cttttgcggt cagcataata 1834321 atgggtgtcg cttttttttc acgaatttgc cggcacactt caattccatc agtccccggc 1834381 atcatcagat caagcaaaat taagtcataa ttggcttcaa gccctttggc aatggcttca 1834441 tcaccatttt cagcttcatc tatagcataa ttttcacgtt caagatacat tcttaaaagg 1834501 cggcgaattc tggcttcgtc atcaactact aatatttttg tttcgttcgt ttggtccatg 1834561 ttttccccct gctttccttc tgttactttc attttatcaa atcgtgagaa agtttgagaa 1834621 ctgtgtcgct ttcaaaggac tatgcataag aatgaagtcc ggcaagcaca agatttacga 1834681 atattaaatt aaacataata atagcaaaac cgattacggc cagccatgct gacttctcac 1834741 cgtgccagcc tcttgacagt cttaaatgca agtaagcggc atagaacaaa aatgtgatca 1834801 gcgcccatac ttccttaggg tcccagcccc aaaatctggt ccacgcgagc tgagcccaaa 1834861 tcattgcaaa gatcagcgcg ccgagtgtaa agatcggaaa tccgattgat acggccctgt 1834921 acccaacctc atccaccaga tcaagattga cgtttttcac cagcggatgt aatagagcgc 1834981 tgattctttt tctgatgatc agacggagag ccccatacaa cacaagacct gctccaaatg 1835041 accaaatgac agtgttcact tttctgcctg agaaaagcgc gggaagatca acaagcggtt 1835101 ccattcttcc ttcggtcaaa agctctccct gatgcggacc gacaagcgcg ggcatttcgt 1835161 acaccatcac gcttttttct ttacttttgt ccacccagtt aaactccgct tcatagcctg 1835221 caagacgaaa tgccgatgtg attgcaataa aggcgacggt tgtgaccagg ataaacataa 1835281 tcgcttcaag ccagaaggtc tttttgcttg gctttgtctg gtctacatgc ttcaaaagaa 1835341 agatgacacc agcgacaaag ctgatggcaa gtatagcttg cccaagcgcg gccgttgtta 1835401 cgtgaatata cagccagtta ctttggagcg aaggaattaa aggcgagata tctgtcggaa 1835461 acatgctggc gtaggcaatc agcaataaag caattgacag cgtaaacagg cctaatgaag 1835521 gcaatctata gagaaaataa agaatgataa acgccaaaac aagcatcatg ccaaaagcgg 1835581 tggtgaattc aaacatattg ctgacaggcg catggccgct tgcagcccac cttgtgatga 1835641 aatatcctag gtggcagaaa aaaccgacaa tagaaagggt gattccaatg ttggcccatc 1835701 ggtttggcct gcccttttta tctttattcc cgcgtatggc cccgccgaag attgggacag 1835761 cgattaaata cacaagaaag gccgcataaa gaaaatttcc gctcagctct gccatgacat 1835821 cactcccttt tcgcctattt ctgtgttttg attaattctt tttggtccac cggttcagtc 1835881 agtccggaat cagccaatat aaatgctaaa tccttcttca ggccaaacca gtttttattg 1835941 gtatgccctg ctaccataac tgcaccgtcc tgtgagtgca gccaaattct tcgatgctgc 1836001 cagtacatac cttgaatgac accgatcata aaaatggctc cgccgacagc aagcacccag 1836061 agtgtcagat cctttctgac tgtaagtcca gtaatgtttt tcgtttcgac atggtcaaat 1836121 ttcagcttgt atttattatt gcctgatcct tcgatggttt cttggatggc gacaaagctc 1836181 ttttcgcctt tcggtttgtc cggcgttatg atattaaaga caaaagccgg attgttaggg 1836241 atctttgttt ttgtgctcgg ctctccgtcc tgattaaaat agaagtcagg caggtagctg 1836301 gcgatttcca ccttgtaacc gttaccaaga tcatagactg aatctggatc cagaaggttg 1836361 atcttcaggc tcccaaagga tttttttgtt tttttatcaa tcagctggaa caccatttgg 1836421 tcaagctgat tctctttgta atccacctgg taaacggaaa aagaatcaaa acgcagcggc 1836481 tgattgacac ggatgtcttc ttctgttact ttttccagct tcggcttctc gccataaaca 1836541 atttttcctt ctctcttgta gagtacggca tcagtttgaa agttctttgc cactctaccg 1836601 tccccgactc tgtcaatggc atctgcaaat accttttttt ccgttttgct gttataggtc 1836661 tctacgctga attgattgtt tttcaaataa tattttccgt ctgtacccgg aattgctgcg 1836721 gtttcgcctt ctctgaccca aagcgtctca tcgacgtaca tgccaggcac aaatctcagc 1836781 atcgcaccaa tcagaaagat gatcaatcca atgtggttga catacgggcc ccagcgggaa 1836841 aagcgtcctt tttcagcaag aatgctgccc tctttttctc tgattctata atgttttttc 1836901 tttaatagag taactatctt ttctttcgat tccccgttca gtacagtaac tgtttcactg 1836961 aacaagcgct gccttcttaa aaaggccggg ctccttctga caccttggtt ttttaacgct 1837021 ctatacaacg gaatgacccg atcaaggctg caaatcacga gtgaaatgcc gatcgaggca 1837081 atgagcagca aataccacca agaaccatat aaatgatgaa acccgagcaa ataataaagc 1837141 tggccaaacg tgccgtactg ctccttgtaa taagtatcag cctgtgcgcc cggaggcaga 1837201 taggcttcct ggggaaaaat ggtgccgaac gctgatgcgg caagggttat gacgataagc 1837261 catattccca ccttaaccga ggaaaagaaa ttccaaattt tgtcgatgat cgttttgtta 1837321 taggtttgcg aacgtcttgc gcttccgtca tatctcatat cagcgagcgg aggttgagtt 1837381 tcctgaagag ctcttccgca cgattcgcat aaaacggttc cgaccgggtt tatatgtccg 1837441 cattcacatt tgacttgctt catcccgaag tctctccggg ttttatgaga ttcatataat 1837501 cgtgtatcat gctttctgtc atagtgccgg tcaccacctt gacaactttt ccttccggat 1837561 tgatcaaaaa ggttgtcgga agcggagata cgtcataggc atcaagcact tggcgatctg 1837621 tatccagaac aaccgggaaa ttgactccgt aggatttcat aaaattatgt actgctatct 1837681 ttgactcccc aacatttaca gcgacaattt caacaccttg gcttttaaaa tgcttatatt 1837741 ggtttgccat ataaggaaac tcttttttgc acggttcaca ccatgtaccc cagaaattca 1837801 aaaaaacacc tttccctttt aagtcactga gctcgatacg tttcccattc gtatcctcta 1837861 ggacaaaatt cggtgcgtcg gacccttcgg atatactctc tttgccggca aatacagcgt 1837921 tgtaaatggt atagccgagt gcgcagatta aaacgagaag gatgccggtc cgaatgaata 1837981 aacgcctttt tttcttcatt gtccactgcc cccttccccc tattgcagat ccattcaatt 1838041 atatcattgc acgttcattt cacatttctt actttttgaa ggttatgtga aatttagaaa 1838101 gcgtttttac cgtgatccgc cagtgctctg agccttttta cttcgtgagg cgtaagctct 1838161 ctggcatcgc ccgtgtgcag gcctcgcagg tttaaaaacg cgtattcctc acgcttcagc 1838221 ttgattacct catgtccgat cgcttcaaac atgcggcgca cttgtctgtt gcgtccctca 1838281 tggatcgtca gctgaataat gcttgtctgc tttttcttat ccaaagacag cagcttcgct 1838341 ttagcaggcg ctgttttgcc ttcctccagc ctaattccgc gctccagctt tctgagcagc 1838401 tctttaggcg ggattccttt caccttcgcc acgtatgttt tgtctatttc atacttagga 1838461 tgcattagct tattggcgaa ttcgccgtca ttggttaaaa gcaaaagacc gctcgtatca 1838521 tagtccagac gcccaatcgg ataaatgcgc tgcggaatat ttttaaaaaa gtccgtcacc 1838581 actttgcgtc ctttatcatc ttgcgctgcg gaaataacgc ctcttggttt atataagaga 1838641 aagtaaaccg gctcttcgcg ttcaaccttt aacccgttta cctcaatctg atcagaaccg 1838701 gtgaccttaa cacctagctc tgttactact ttgccattca cctttacttt tccttcttta 1838761 atcagctctt ctgcctttct gcgcgacgca actccggcat gagcaatcac tttttgcagt 1838821 ctttccatgt ctttcacctc aagtattatc ttactttttt caaccttaac aaacaagctt 1838881 tttcaaattc ctatgccaaa tctaaaaaaa acgccgtttt caggcgctcc caaataataa 1838941 cgtaacgatg atgatagatg caactacgcc gattaaatct gcaagaagtc ccacctttaa 1839001 tgcatcaccc atttttttaa tgccgactgc tccgaaatac acagtcagta cgtaaagcgt 1839061 tgtatctgta gatccctgca tgacggaagc cagcctgccg ataaaggaat cgggcccgta 1839121 tactgcaatt aaatcggtcg tcattccaag tgcggccgta ccggagatcg ggcggatcag 1839181 agcaagcggc actacttcag cagggatgcc gatagcggag aaagccggtt ttaaaagatc 1839241 cattataaaa tcaagcgcgc ctgatgatct gaaaacagtt atagcgacaa gcattccgac 1839301 taaatagggg ataatggaaa aggcaatttc tatcccctct ttcccgcctt cgacaaacga 1839361 ttcatatgtc ggaacctttt tgatcgttcc ataaagaaga attccggcaa taatgattgg 1839421 aatcatggct aaagacagcc agttgatgat ttccatccgc tcaccttccc ttctttttgc 1839481 ggcggtaata aaaataccga tcaatgataa tggcaccgat tccggaaata agcgttgcca 1839541 aaatgcttgg cccgacgata tctgtcggcg ttttggagga ataagccatt cggacagcga 1839601 tcaccgttgt cgggatgagt gtgatgcagg acgtattaac agctaaaaaa gtaatcatcg 1839661 accggcttgc ttccgatcgg tttccgttca gctttttcat ttgttccatt gctttaatgc 1839721 caagcggagt tgctgcattt ccgaggccga agaaattcgc cataagatta gataaaatat 1839781 agcccatcgc cgggtgatcc ggcggtatat cagggaacag tttagatata aaaggtctgc 1839841 acatccggct gaaaatatcc aaaagccctg actgctcggc gattttcatt aagccaagcc 1839901 agaaaacaag cacgctcatc aatccaaatg agatcgtaat cgcttctttc gcacccttaa 1839961 acacggcttc atttacatct tgcagagttc cgttgcacat cgcaaaaacg agtccgatca 1840021 cggttaaact gacccaaatt atattgacca ttttgctccg cctgccgcat tcagaaagat 1840081 tgatttaaac gtttcaaaaa attgtttctt cggtttttga tgccgctcat tttcataata 1840141 gatcggcact tttgcgatgg ttgcatcgtt gaacatgatc tccatgtgcc ctacgatgtc 1840201 agggattttc gaggcatctt tttcccatgc ttttttcggc ttgagcagtg tggtattaat 1840261 ttttacattt tctttttcct cttcggtcag caaataggtg atatcacgtt tgataaaagc 1840321 cttcgattca taaaatgtgc ctttcagctt tggaatatcc cctttttttg caattaaata 1840381 ggtttgataa tgctcaaaca catagttaaa catcttcata tggtcatccc aatcattagg 1840441 gtcattaatg gtgacggcta tcaggtcaat gccgtccttt gaagccgtag agaccagtgt 1840501 ccgttttgca agttttgtat agcctgtttt tcctcctgtg ctgtacggat aaagcatggt 1840561 cagcagtttg tttttgtttt tccatacgct ttccatcgtt tccgctttgt atatttttgt 1840621 gcctgaaatc ttttgatagt ctttcagctt catagcatac ttagttaaaa tggccatgtc 1840681 ataggctgtt gaataatgat tttcatggtc gtccaatccg tgcgggtttt gaaaacgggt 1840741 gtttttcata ccaagctgct cggctttttg attcatcata taaacaaacc catcgaggct 1840801 cccaccgaca tgctcagcaa tcgcgacagc ggcatcgttt cctgatctta gcatcaggcc 1840861 atacacaaga tctttcagct tcactttttg accttctgtt aaataaatgg cggagccttc 1840921 tgttctgaca gcatttgccg aaaccgtcac tgtttgatcc attttgccgg attcgatggc 1840981 gaggacggcg gtcataattt ttgtgatgct cgcgatccgc cttttttgat gctcatcctt 1841041 ggcatataac actctgcctg acgcaccgtc aataatgatc gcgctttttg cactgacatc 1841101 tatagcagca tgtgctgtat tcacatttac ggttgcaata agaaaagaaa tcatgatcac 1841161 gaatactgct tttttgaaaa tgcgcatgtt tgctcacgtc cttgtggtgg tttgtacaag 1841221 tttatgcgca tgtccatcag ttatgaataa caattatatt tctggaagca aacataaaaa 1841281 aactctccct gaaaaaggga gagtaaacgt tatctgattg gcgccatgct tgatccggac 1841341 gcttcgtaat gagccagctc ttccctcatc ttcagaaagg ccgcgctcaa cggcaataat 1841401 aattgctcaa gcgacgcagg aacagcatga taaaactcaa ttgcgctgac cccggtataa 1841461 gacgcccggc tattttcaca ccacgtgtct tttttcggca taaagaactc ttcaatgcat 1841521 tggtgataca cattataaag tgttttttcc gctctggctt cctgaaaagg ctcctgcatc 1841581 aggagacgac ggcacgcttc tgcgcctcct tcacaaaata ctgccattct tctcagagtg 1841641 ctaagcacat cacagcagta tcctttttca ataggcaatt cagcctgtaa ggactcaagc 1841701 gtcgtttgat ttaggtaatc gttcacggta ttgacaacca ttgataagaa ttcgcctgtt 1841761 ttttgagtct gcgctcgcac aatcgaatgt cccatttcgt ttggtatctt cccctcatgt 1841821 atttgtctct cacattttgc ttctttcatg atagcttctt ccttatatct tatgatgatg 1841881 aaaaagcgcg attcattaaa cttctatttt atatcttcga aggtttggtt aaagttttca 1841941 aaaaataaat ctgcttcttc ttgaagaacg tcttcttccg cattttcagg cagcggcgga 1842001 agctcgtcca gcgttttcag accgaattgt tcaagaaaag tcggcgtagt accgtataaa 1842061 atggcccgcc ccggaccatc ggcacgccct acttcacaca atagcgcctt cgcgacaaga 1842121 ctgtgtaaaa tccgctctga ttttactcct ctgatttctt caatttctgc tctcgtaatt 1842181 ggctgtttgt atgaaacaat ggccagtact tctaaagatg cttgagaaag gccctttgac 1842241 ggcacttcaa tcagtttttt caagtaaggc gcaaagtctt ttttggtaga gagcatgtac 1842301 gtatctgcat actcaataag ttcaatccct cgtgtatctc cgcggtattc gtccgccaca 1842361 tccgccatga tcgtgttcag ttcaggctct tcgatttcaa gcactgttaa cagctgcttt 1842421 tttgtaagcc cttcatcgcc tgccgcataa agaagggctt ccacaatagc tttccaattc 1842481 acgatatcaa gccccatgaa tggattcact ccccgtaatg taaatatctg aaaaattgtg 1842541 ctcctgttca atgaggacca gctgattttt catcagctca agaacagcta gaaaggtcac 1842601 tactaaatgt tctttttgct catatggaaa cagatccata aagttaattc tcgttcctct 1842661 agatttcaag ctgtgcacga tttcgttcat tctggcttcg attggtatgt cctgtcttgt 1842721 aattgttgtt tccatcggcc tgtttatttt tttgcgtttc agcacttttt gaaaagctcc 1842781 gatcatatca tagaccgtga cagagagctt ttgctcagac tgttttactt cttttgcata 1842841 ttcactcaaa tcactcggcg gtttcgtgaa cgatttttgt ctttcttctt cccgttcttt 1842901 taaatccttc gccgcatctt tatattttcg gtactcaatc agcttttcaa tcagttcctc 1842961 ccgcggatct tcttcttcaa gtaattcatc ttcaaaaagc tcctcctctt gcttcgggag 1843021 cagcattctg cttttaatgc tgagcagcgt ggcagccata accaaatact cgctggcaat 1843081 gtcgagctca agcacgcgca tcgtatgtac atataataaa tattgttcag tgatcttcgc 1843141 cacaggtata tcatatatgt caatttcaag acgattgatt aaatgaagca gcaggtccaa 1843201 tgggccctca aacgtatcaa ttttcacttg atattcttcc atcatctcac cattttcaag 1843261 tatcactctc attgccggaa aaactggcta ccctatagta taagccacca aaaagctctc 1843321 gtccaatact atttcatatc ctgttttgaa ggagtttgta cagaatattc aaaacacaag 1843381 aggtgtttgc tcggagcgca gaagcgggag aaaaagcctt tgcttctggt tttcctttct 1843441 aagaagcact agaggccggg cgttcttttt tccttttatc ccttctatgg tacactaaaa 1843501 gcacattaaa ggaggaagca ccttgtatcc gaaagcttat atagattatc tcgttgagtt 1843561 tcatgcgaca cgggattatt ttgaatgcca tgaaatatta gaagaatatt ggaaggaaga 1843621 tccgccaaag aaacgaaaac gctattgggt gggctttatt cagcttgcag tggctttata 1843681 tcatcacaga aggcagaata cagccggggc aaaaagactg atggcgaaca gcatccggat 1843741 tcttcaagca gaacaccggg cagtcgaaga cttagggctt gatcatggcc gtttgctcga 1843801 acttatgcaa tcggtttacg aacaaatcga aaccgtctct gcctataaaa gcattatact 1843861 gccaatcaaa gatgagaaac tggaggaagc atgcaggatc gaatgcagga aaaaaaagta 1843921 tacatggggg cagcccagtg cactcagcaa catatttctt atcgacaaac accgtttgcg 1843981 ggatcggact gacgtcatcc gtgaacgtga aaaagaaata gaacgcagaa aaaaaagcag 1844041 agactgatca cagcctctgc ttaattattg tatgaaatgt cttgatcctg ctgaccttga 1844101 caacgttcga aaaagctctg cgttaattca tttggaacca gtacttgcgt tttgaataaa 1844161 tgctttaaag catccatcat ctgttttccg attccttgat ggcgatgaga aggattcaca 1844221 ctgatatgcc ggatctcaac ctcagaatcc tttttttcga ctccgattgc tccgacgata 1844281 tcctcgtcct ctttccaaag aaagagctgg cggtctgtat ccgtttcgta gtccttaatt 1844341 gtctgctgaa gctgcttaag gtctttttca ttcggcataa acgaaagaag ccccatcgca 1844401 atcttttcaa acgatttttt ataacgaatt aacataaaaa cccctctata tccaaaatgt 1844461 ccagtctgct attaacggat acgaataggt gatccgtttt ctcacattat atcattttcg 1844521 ccatattttt aaactgtttt cagcaaatta ttcaaatgag cggtttaaat ttgccatttc 1844581 aatggcagaa acagcacaat ctacaccttt gttgcccgct tttgtgccgg cacgctcgat 1844641 agcctgttcg atgttttcag ttgttacaat tccaaagatg acaggtacac cagtagtgtt 1844701 tgctgcttgc gcgatgcctt ttgcagcttc attgcagaca taatcgtaat gtgtcgttgc 1844761 gcctctgatg acagtgccca atgtgataat agcatcatat ttttttgttt ccgccatttt 1844821 tttcgcagca aacggtattt caaatgcgcc tggaacccaa gccacatcaa tgtcatttgt 1844881 gtctacgcca tgtctgagca gcgcatcttc tgctccgctc agcagcttgc tcgtaataaa 1844941 atcattaaat cttcctacta cgattccgat tttaagacct gtaccaacta aatttccttg 1845001 tatgatattc atatgattcc catccttttt tgtgatattt gtgattagaa atgaagtaaa 1845061 tgacctagct tgttcatttt ggtttgcaaa tattttttat tgtgttcttt cgcctccatt 1845121 tgaagcggca ctctttctga aatactgagt ccgtagcctt caaggcctgc gatttttcgc 1845181 ggattattcg tcaaaagctt catattccgg acaccgaggt cgcgtaaaat ttgtgctccg 1845241 atgccatagt tgcgaagatc cggcaagaat ccaagcgcct cattggcttc tacggtgtca 1845301 tagccttgtt cctgaagctt ataagctttt aatttattga ttaaaccgat gcctcgtcct 1845361 tcttggcgca agtacaggag cactccacgg ccttctgcgg caatttggtt cagcgcggcg 1845421 tgcagctgcg gtccgcaatc acagcgatga gagccaaaca cgtcacctgt gagacattct 1845481 gaatgcaccc ggaccaatac cggttcttct ccgaacggca catctcccat cacaaatgcg 1845541 acatgctctt ttccatctac ctcatttgtg tatccataaa ccttaaatgt cccaaaatca 1845601 gtaggcagcg taatgtcaac ttcacgctcg acaagtgttg tcagattgta acggtattga 1845661 atcaaatcct taatggtgat catttttaat tgatgctttt tcgcaatttc aatgagctca 1845721 ggcactctcg ccatcgttcc gtcttcattc ataatttcac aaatgacgcc ggctcctgga 1845781 gatccgcaag cttcagcaag atcaacagca gcttctgtat ggcccgctct tttcaggaca 1845841 cctccttttt tcgcaatcag tggaaaaatg tgccccggac gctgaaaatc agatggcacg 1845901 gatttgctgt ccagcaatgc ttgaacggta aaagatcttt cttgagcgct gatacctgtc 1845961 ttcgtttcac gatggtctat gcttacggta aatgcagtgt ggtgagagtc tgtattatgc 1846021 tcaaccatag ggtgaagatc aagcctgtct gcgatttcct cactgagcgg cgtgcagatc 1846081 agtcctctcc catgtgtcgc cataaagtta atgacttccg gcgttgcatg ctcggcaaga 1846141 gccacaaagt ctccttcatt ttctctgtct tcatcatcta caacgatgat gacttcgcct 1846201 ttttttaaag cgtccagtgc ttcttctatc ggatgaaaca tgcaaatctt cctctctaaa 1846261 agccgttttc gcttaagaag gcttttgtaa tggtttgttg ggtcttattt tcattggctt 1846321 tatgcaaaaa tcgatacata tattttccga tcatatcgca ttcgatattc actttagagc 1846381 cgatcgtttt ttctgaaaag atcgtttcgc tgatcgtatg cggtattaag gagatcgtca 1846441 ctgtgtcttc tgtcaggccg aatatggtta agctcacgcc atccacagta attgatccct 1846501 ttaaaaccaa tgtttttgtt aatgacgggt ccatttttaa atcatagtaa actgcgttgc 1846561 ttttctcttc aattcgtgtg atttccgcag ttccgtcgac atggcctgag acgaaatggc 1846621 ctccgaaacg gccgtttgcc gccatcgctc tttccagatt tactttgctt ccttttgtta 1846681 aatcattcag tgacgtagct ttgactgttt caggcataac atccactgtg aattgatttt 1846741 ttgtaaaatc agtgacagtc agacaaatgc cgttcactgc aatgctgtcg ccaagatgaa 1846801 catcctctaa aatctttgag catttaatag ttaaggccat tgcatgccct gcttttttca 1846861 tggattcgat tgtgcctgtt tcttcgataa ttcctgtaaa catggtcacc atcctattcc 1846921 tttgtcggtt ttgccgtcag tttgatatca cggccgattt gggttatatc agtgaattgt 1846981 aataagggga catctttcat tgattgaaaa ccttcaccgg agattaagct gggagcatgc 1847041 gttcctccga ttagtttagg ggcaaaatag aagatgattt cttgaaaaca gccttctttg 1847101 acaaagcttc cgtgaacagc tgaaccgcct tccacataca ccgacatgat gccttcttcc 1847161 gctaggatct tcaaaacatc aggaatttga atgcgctcgg tttcaagtgt aaatatgttc 1847221 actccgaaag ctgaaagccg ttttttcttt tcctcgtctg cgcgtgccgt cgtaaaaatc 1847281 catgtcggcg ctatttgatc gcaaatcact ttagcgtcct caggaatcga gagtacggta 1847341 tcaagtatga cccgaaccgg ctgttttgtt acattcggca gtctgcaggt taagctcgga 1847401 ttgtcggctt tcactgtgcc aactccgact aaaatgcttt ggtgtgtttt cctgtattgc 1847461 tgagcatcct gtcttgcagc ctctgacgtg atccatttgc tgtcacccgt gctggtagct 1847521 atcttgccgt caaggctggc agccgctttt agcgtgacgt acggaaggcc tgtcctcata 1847581 aagtgcagaa atttttcatt cagcctctcc gcctggtctg ccaggatgcc ttcccttacc 1847641 tcaatgccag cttctttcat catgctgatc cctcttccag ccacaagcgg attaggatct 1847701 ctcatcgcca cgaacactct tttgatacca gagttgataa tcaattctgc acatggcggt 1847761 gtttttccgt aatggctgca cggttcgagt gtaacgtaaa tgtcggcacc ctctgcatgt 1847821 gctccagcca tatggatggc atgaacttct gcatgagctt caccatattt taaatgggcg 1847881 cccattccga caatttgtcc gtcctttacg acaacagcgc cgacgagcgg attggattcg 1847941 gtctgtcctt cgccctgctt cgcaagatct aaggccagct tcatataata ctcttccatt 1848001 tgtttccctc ccctcttttg ttatttaccg tcaaaaaagc cccgaattta taaaaaattc 1848061 ggggctttag gtattttacg caataggaaa taacactatg catttttaaa cattttgcat 1848121 agcggctcat catccttctc ccatccagac tttcactgtc ggcttcagct taaactgaat 1848181 ccaccgcgtg cttatgcaca cgggtcacgg gctctaaagc aaatgtgctt tactaccgcc 1848241 ggtcgggatt tccaccctgc cccgaaggat acaatcttta ttcatttgtc cttattggtt 1848301 attatagcga tcctttttaa agtacgcaat gaaataaact tacaatttga gaaaaacaaa 1848361 acatcaccct tcgatccgaa aggtgatgtt ttttaatcat tcacttttgc aaccttgatt 1848421 aatccgtcga tccgctttga tttgctgaag taagccttaa tcttgtcacc ttcttttata 1848481 tcagataaat cctgatttaa tttttttccg ttgaagatga ttttcgttcc gttttctgct 1848541 actccatgat actctgagcc gtcaattttc gtcactttat attcctggat ggtgtattcc 1848601 tcttcttccg aggacaaggt ttgtccaatt gctgtcggaa catccttcag ctcaatatca 1848661 tttatgtaca tataaccgcc tgcaagtaaa agcaaaagca ctaacagaat ggtaatcttg 1848721 gtttttattc ttcccatttc taaacctcca gccaatatga atctattcat tcatatgagt 1848781 tattcctttt tttcatgaat aaaaaaccgt aaattctcgt aaattattaa tataacgatg 1848841 cataacggga atatgtttca catttctgca aaaatttctt ttctatagat atacgaattt 1848901 atgttctgtt tttaggggat gaccgtaaaa aagatataaa aaaagcagcc ccaatgggaa 1848961 gctgcttgat cctaatttgt tttgcgcatt tcgttaaacg ggtagaaaac aaactttgac 1849021 gtacccgcaa tttgtttttt cgtgaagagg ccaaggccgt tacggctgtc catggaattg 1849081 cgacgattgt cacccatcac aaaatacttg ttatcaggca ctttaaccgg gccgaaatca 1849141 tcggtcaaat ggtcaaaacc gtcctgtttc gctctctttt tattagccgc caaataaggt 1849201 tcgtccacct ttttcccgtt gatatagagc tggtcatttt tcatctcaac cgtatcgccg 1849261 ggaaggccga taatacgttt gacatagtga acatcatctc cgtttaacac gacgatgtct 1849321 cctctatcaa actcgccgat gtatttgact gtcatattaa caaaaaccct ttcacggttg 1849381 tgaagtgtag gatacataga gtcaccatca acgacatacg gcgcaaaaat aaagttgcgg 1849441 atgagcaaag caagaacgac agcaatcaca attgcttttg cccattctaa tattgacttt 1849501 ttcttcgaaa cattttctga tttcaactga tttcctccaa taaacaacgg tcttcaattt 1849561 atgttatcac gaatcgaaaa aaaatcccat taggaccatt gaagtgattt tacaaactgt 1849621 taatcttcat cttctaccca catcatgcct attttttctt gtcgatcata actaggcctg 1849681 aaaatattga aagaaatgaa tcgcataatt cagaagcgat ggactcagaa gaaagagagt 1849741 tctcatatgc aaaatcttta gatcgtatat aaagcatgag gttacgggca gtttgttcat 1849801 ttactgcatt ccattgatct cccagtccat gatacccatg gcacttgaca aaacaattaa 1849861 cgtcatgaag gttactggaa tgtttgcggc aacctatttc acaggtgata accgcacccc 1849921 gttttttgct ttcataatat gtttaaaatc attcaagctc gaaaacatgg atcagcctcc 1849981 aaaaaataaa tccaatatat tcccggcagt tgaagactct ttattataaa actctgaata 1850041 tccgcagttc ttacagtaaa ccactagaaa tcggttatgc tgcacgtcaa acagctttga 1850101 taatcccgtg ccggttgtag ctatttcttt ttgtccggct tcagtactac cgcattttat 1850161 acagcctttg ttgttcatat cgcgatctcc ttttcattac atcacgtttg tttgatttat 1850221 tttactacaa aatatcaatc ccaatgaccc gtactacttt aaagtttact taattttgat 1850281 tacatactaa ttgggttcgt ttctcagctt ggtaaatctt ctggagaaac ggaaaagctc 1850341 catgaccaaa acattcaaac tcagccaaac accgccgaag gcgtaacccg cagcaacatc 1850401 actcggatac tgctcataaa gtacacacgg ctcagcccga tgaggaataa aacgataata 1850461 aacaaaaaaa tgcaacagtt tgcagacgcg tcttgtgaga atgacgaaca aaaagataag 1850521 cacaaaaacc aaaaatgaca aatgccgtta aagtctgttc gctcgggaat ggatataata 1850581 catgactttc caaaggagcg tgaacaggat gaagggaatg aaagagccgt ctgattccct 1850641 cttcataaag ctccccacca atgactagga aaaataagaa agagagttcg attttccgat 1850701 cttgccctct gaataccgtc caaaaaaaag ttagaacaat aacggctaac agaacacctc 1850761 tcgacgcaaa agctttctga attgcagctg ggcccagtct atacccgatc caatacgaca 1850821 tgctcactcc cacagctccc caatccggcc gctaacatgc ttagcaccca gtttaacttt 1850881 tcttgaaaca cgagaacacc ggcaaactct cccggtccaa gtaaagctag aagctctaac 1850941 atcaagacaa taaacaagac ggcatatccg tactgttcga gcaaccccgt caaaacttgc 1851001 atgtgattct ccttaaactt ttttgttctt ttatcattcc caatccactt tttgtataat 1851061 cagcacaatt ttatcttcag tcgtccaaca acattgtcta tggcgggatc ttctctcata 1851121 cattcttttt tgacatagga ggagcaatag catgaaatgg gaggaaacaa aagatacgca 1851181 gggagtttgc caaaattttg ggcagttcgt tctgccaccg agtcaggtgt ttgtttgccc 1851241 acctcatccc ttgtcaattc cccatttttc ccgtttgagg ttcgaaatgg taaagtattt 1851301 cacttagttt cttacatgaa gaggtaaatt ctttgctcac cgaactagga tagcggcgta 1851361 tggcgatttc tacattgcat aaccactggt tatttagtga gccgtgagca atgtatatgc 1851421 actttgagtc agcacaggat gatcctatta cattcgccag aaaagcagct gccgcattca 1851481 gagtagttaa aagaatagac agatatctgg gcttccggaa gctttaaagg aggctctttt 1851541 ttcgagcatt tttataaatc aataaaaaca ggcatctcct aaatattttt gccgataagt 1851601 ttacgctaat caactctagc actaatacat ataaaaaata gaatgatatg aaaggagact 1851661 tgatagtatg attgattatc ctattaatat aaacaacgtt tccgggaaca gtgtaattaa 1851721 cgtaggcggc gcttttatga tcaggccttt aactttgtcc aaatctgtgt ttggctccgg 1851781 aggtttaaac acaggaattg tctttgaaaa taactttgta agcaaagcta aaatgattaa 1851841 tcatcaattt actgatcaaa acgtcaccaa aactttttaa tgtattcaat acacgggggt 1851901 cactaactaa acacctggtt ttgccaaccg ccatcagcat tcggcggttt tttattgaac 1851961 atttttggcc aataaaaaaa gcttcctctc taagaggaag ccttttgcct gccgattagc 1852021 cttctacacg aacttctttc atgacatcgc cattagacat gtttttcgcg aattctaatc 1852081 cgcttgttac tttaccaaat acagtgtgaa caccgttcaa atgaggctgt ggctcatgaa 1852141 cgatgaaaaa ttggctgccg ccagtgtctt ttccggcatg tgccatagaa agtgcgcccg 1852201 cctcatgtgt atgcgggttg ccttctgttt cacatttgat tgtgtatccc ggaccgcctg 1852261 taccagttcc gtgcgggcat ccgccttggc tgacgaagcc agggatcact cggtggaatg 1852321 taagcccgtc ataaaagcct tcgttcgcaa gcttttcaaa gtttgcaaca gttccaggtg 1852381 cagcttcagg ataaagttca aattcaattt tgttcccgtc ttctaataaa aagtaacctg 1852441 ttttcaattg tatgcctact ttctttattt taattttcaa aggagattat gtataggtta 1852501 tagcctgtct ctccttgtcg cggctattat accacacctt tcgggggaaa acgaatctcc 1852561 cgagctttac taaaaaataa aaatgaaacc tgaatctctt tatctccgtc taacctaacg 1852621 gaactgtatt tttcatgatt caggtcctca caaagcagca ctatccagct gcttgtgaaa 1852681 ttgaaggagg tcaaactgct ttgaagaaaa tttggattgg aatgctggca gcggccgttt 1852741 tgctgctgat ggttccgaag gtcagtctcg cggatgccgc agttggagat gtcattgtaa 1852801 cactgggtgc tgatttgtca gaatctgaca aacaaaaagt gcttgatgaa atgaatgtcc 1852861 ctgataatgc cacaacggta accgtgacca ataaggaaga acatgaatat ttaggaaaat 1852921 atatatcgaa cgcgcaaatc ggatcgagag cgatttcttc atcgtcaatc accattgcca 1852981 aaaaaggctc cggattgaat gttgagaccc ataatatcag cggcatcaca gatgaaatgt 1853041 acctgaatgc actgatgaca gccggtgtta aagatgcgaa ggtgtatgtt acagcaccgt 1853101 ttgaagtatc cgggactgcc gctttaactg gattgattaa ggcgtatgaa gtttcttctg 1853161 acgaagcgat ctcggaggat gttaagcagg tcgccaacca agagcttgtc acgacatcag 1853221 agcttggaga caaaatcggt aacgaaaatg cggcagccct gattgcaaaa atcaaagaag 1853281 agtttgctaa aaacggggtg cctgataata aagctgacat cgaaaaacaa gtggatgacg 1853341 cagcttctga tttaaacgtc acacttacag acagccaaaa gaatcagctt gtctccctat 1853401 tcaataagat gaaaaacgct gacattgact ggggacaggt cagtgaccag ctagataaag 1853461 cgaaagataa gattacgaaa ttcatagaat cagatgaagg caaaaacttc atccagaaag 1853521 tcattgattt cttcgtatct atctggaatg cgattgtatc tatattcaaa taagaaaagc 1853581 gccgaaaaat cggcgctttc ttttattgct ttacacccgt tttaaatggc agatcaagtt 1853641 ttacaatatc ttcgtatgtt tctcgcttca cgactaaatg agcctcaccg ttttcgacaa 1853701 atacaacggc gggtctcgga atacggttat aattgttggc catgctgtat ccataagcgc 1853761 ctgtacaaaa aacggcaaga agatcgcctt cttttacttc cggcaggtca atatcccaaa 1853821 tcagcatatc tccgctttca cagcactttc cggcaattga taccgttttg tcatgcgctt 1853881 ctccgatcct gttggctgcc gcagcttcat atttagcttg gtaaagcgca ggacgaatat 1853941 tgtcgttcat gcctccgtct acagccacat attggcggac acccggcact tctttttgag 1854001 agccaaccgt ataaagagtt gtgcctgcgt ctcccacgag agaacggccc ggttcgatcc 1854061 aaatttccgg aatgtcaaaa ccgtaacggg aagcattttc tttcacagct tcgataattt 1854121 tttcaacgta ttcagtggca tgaagcggtt catcatcttc cgtataacga atgccgaaac 1854181 ctcctccaag attcagcacc ttggatacaa atgaatatga atctctccat tcgtctagtt 1854241 ttttgaagat tttttccgct gctaacacaa aaccggccgt atcaaagatt tgcgagccga 1854301 tatggcaatg gacacccagc agctgaatgt gttccgattg taatacttgt tcaatggccc 1854361 gttcagtttg tccgttatga agatcgaaac caaactttga atcttcctgg cccgttgtaa 1854421 tgtagtcatg cgtatgcgct tctactccgg gcgtgatccg aagaagaaca tcgatggagt 1854481 gacccgtttc tttacatagg tcttcaagaa gcgcgatttc atagaaatta tccaccacaa 1854541 tgcagccgat gcggtgctca agcgccatcc gcagttcttc cctgctctta ttgtttccat 1854601 gaaagtggat gcgttctgcc ggaaagcctg ctgcaacagc cgtatatagc tctcctccgg 1854661 atacgacatc taaagaaagt ccctcttcct cagcgagctg aatcattgcg actgatgaga 1854721 atgctttgct cgcatatgcc acctgtgctt tcagccctgc agaaataaac gcctgcttaa 1854781 agcttttagc acgctcacgt attaaagcca catcatatac gtaaagaggt gtaccatatt 1854841 tctccgctaa atagagagca tccacacctc cgatttctaa atgaccatgt tgattttgtc 1854901 tgcttgtgcc gtgtaagaac aatgtcattc cctctttctc cgcttatgga tgaaaggaca 1854961 gttttatgga ctgtcccttc ataattaaga catacattat catactcttc agtcagtttc 1855021 aatgcgatta tgaattggta ggctgcctta agcgattttt ggggtgaacg atgctgggtc 1855081 ttacttttgc gccaggtttc gctgtgcgga caagaacctg ccacagcgcc tttccgttaa 1855141 agggaatcag cggccataag tacggtgtct gaagggattt gatgcttgcc atggcaataa 1855201 ttagcactgt aaatccgatg acgagccctt ttatatgaaa taaagcaacg agtatcatga 1855261 ggacaagacg gctcattttg tttgccaagc ttaattcata actaggcgtc gtaaaggttc 1855321 caatcgccgc aagtgagacg tacagaatca cctcaggaga aaaaaggccg acctcaatcg 1855381 caatctgccc gatcagaaca gcggcaatta aacccattgc tgtcgataaa gccgtcggtg 1855441 tgtgaatggc agccattctg agaaactcga ttcctaagtc agctaaaaat atctgcagga 1855501 tgatcgggat atgcgtatct ttatttaaac cgataaattt catgttgtcc gggagcagat 1855561 caggctgaag cacaaagaga aaccagatcg gaagaaataa agtagaagca agaataccga 1855621 aaaatcttac ccgagctcgt ggtcattcgg cataattact taaattttgt ccagtctccc 1855681 atcgtccgct ttaagaatgt gataaacccg gctttcttca tatcttcttt tgcagcaaca 1855741 ggactttcag cgagtacttc tccatccttt ttcagaacaa gagtgccaag ctcttggcct 1855801 ttttgaatcg gagcactaat attgtccttc atcttgattt cttttttcac atcgttcata 1855861 tcctcgcctt ttttcgtcaa tattgaaatc ggctcagatg tagtgagttc gataaatttt 1855921 tgtttccctt ttttgacctt tacttttgct actgtttgat ttcgtttata taaaggatgc 1855981 gtttcatatt ggctaaaggc gaagtcaagc atttttgtca cttgcgcgtt tctttcttta 1856041 ggcgtgctcg ctccgaatac aaccgctatg gcccgcatgt ttcctttttt agccgaagca 1856101 gtcagacaat atttcgcttc gcctgtatag cctgttttta cgccgtctac accaggataa 1856161 aatttgataa ggcgatttgt atttacaagc caaaactttt tatctgtatt ttcacgcaga 1856221 taatcttcat acgtgccggt aaacttcgta attgattcgt atttcaataa ttccttagcc 1856281 atgattgcca tgtcataagc agagctgtag tgtccttcct cggtcagtcc tgttgggttt 1856341 ttaaaggatg tatttttcaa tcccagctct tttgcttttt tattcatttt cttcacaaat 1856401 tcttcttcag agccggaaat aaattcagcc atggcgacgg aagcgtcatt tcccgaagcg 1856461 attgcgatgc ctttcagcat ttctttgaca gtcatttctt cgccgggctc aaggaatatc 1856521 tgtgagccgc ccattgacgc cgcatgctcg cttgtacgga ccttatcact cattttgatt 1856581 ttgcctttat ctaaagcttc cataatcaaa agcatcgtca taattttcgt catgcttgca 1856641 ggcgccagtc tctcattgct gttcttgttg taaagcactt ttcccgtgtc acgttctatc 1856701 agcaccgcag acttcgcttc atgagcaagc tccgatgtac gttttccgtc ttgttttgca 1856761 aatgcagacg gtgcaaatgt aagcagcatt ataccaatca acaaagtgga taaaagacgt 1856821 ttcatctcaa aagccctcca tttcataatc ctttttattt tttccaagcg tgatggtttt 1856881 atacgccact gatggaaaat gtttcgaatt ttgggcataa aaaaagacag ctgtgtgata 1856941 tcagacacag ctgtcttttg gtcctgcatt gattcatatt tattcgtact gagcgacgat 1857001 cgctttaaca agctttaaga atccagcttt tactttttcg gtcacttcca taacttcatc 1857061 gtgacttaaa ggctgatcca gaattccggc tgccgcgtta gagatgcagg aaatgccaag 1857121 aacccgcatt cccgcatgat tcgctacaat gacttccgga acagtagaca tgccgactgc 1857181 atcagagccc atcgttctta agaaacggac ttctgccggt gtttcgtaag aaggtcctgt 1857241 cacagcagtg tacacgcctt tttgaattgg gatattaagg tctttcgcaa tcttttcagc 1857301 caggctggac agatctttgt cataggctga agacatatct ggaaatctgg cgccgaaatc 1857361 tgcttcgttt ggcccgatta acgggtttgt tcccataaag ttgatatgat cggtaataat 1857421 cattaaatct cccgcacgga attcagtgtt gacaccgcct gcggcatttg tcacgatcaa 1857481 cgcttccaca ccgagcgctt tcatcacgcg tacagggaat gtgactttct ccattgagta 1857541 gccttcataa aaatgaaagc ggccctgcat tgcaatgacg gaaactcctt caagagtgcc 1857601 aagcacaagc tgtccggcat gcccttcaac agtagatacc gggaattcag gtatatcttc 1857661 atatttcagc ttgaccggat tttcgatttc gtccgccaaa atgccaagac ctgagcctaa 1857721 aataaggccg atctttggag attccggcag gttttgttta ataaaagcgg ctgcgcgttc 1857781 aattctgtcc ttcaagaaac agtcccccta ttgtaataaa gataaaaagc ttttcccgta 1857841 tttcggttta tttgtttgga aattatcagc gatcgttgcg ccaatatcgg caaatgtatc 1857901 tgcaagcggc agcatttgcg ctttcttatg ttttttgctg taagcgagaa tcggcacata 1857961 ctcgcgtgta tggtcagtcc catgatgaat cggatcattg ccgtggtcgg ctgtaataat 1858021 taacagatcg tcttctctca ttttttcaaa cacttccgga agccgcgcat caaattcttc 1858081 aagcgcgcgt ccgtagcctt cagggtcacg gcggtgtccg aataacgcgt caaaatcaac 1858141 aaggttcgca aagctcagac ccgtaaaatc ttctcccagc gtatcgatca ccttgtccat 1858201 tccgtccata ttagaaaccg ttctgcgtga agaagtaatg ccttctccgt cgtaaatatc 1858261 agagatttta ccgattgaaa tcacatctaa gccgcagtct ttcaattcat tcatgacagt 1858321 gcggtcaaac ggcttcagcg cataatcatg gcggtttggc gtccgtttga attgacccgg 1858381 ctctccgacg aacggccgtg caataatgcg gccaaccata tatttcggat caagcgtcag 1858441 ctctctcgcc gtttcgcaaa tgcgatacag ctcctcaagc ggcacaacct cttcgtgagc 1858501 ggcaatttgc agaacagagt cagcagacgt gtaaacaatt aaagcccctg tctccatgtg 1858561 ctcctggcca agctcatcca aaatcgctgt gccggaagcc ggcttgtttc caataatttt 1858621 gcggccagat ctcttttcca gctcttgaag caattcatca ggaaagcctt ccgggaacac 1858681 tttaaacggt ttatcaatgt ataaacccat aatctcccaa tggccggtca tcgtatcttt 1858741 gccgtttgac gcttcttgca tttttccata ataggcaagc ggatgttctg ttttttctac 1858801 acctttgata tcttcgataa gaccaaggcc gagctttgcc atattcggca tatgtaatcc 1858861 gttcatatgc tcggcaatat gaccgagcgt atgagcgcct tcgtcattaa agtcagcggc 1858921 atccggcgct tcgccgattc cgactgagtc catcacaatt aaaaacacac gattatattt 1858981 gtatgcaggc atcttgaaag cctccttttt ttctatacgt ctattgtatc gctaagaggt 1859041 ctgacaactc aagtataaac cgttttcatt cccgttgaca atgtatttgg aaataatgag 1859101 aaacttcaat attttctgtc gctctaaaca aaaaagccgc agccacctgc ggctatgctc 1859161 gcggatgaaa ctgcttgtac acatccttca gccttgtttt cgtcacatgc gtataaattt 1859221 gcgtcgtgga tatatccgca tgaccgagca tttcctgcac cgctcttaaa tctgccccgt 1859281 tctcaagcag atgcgtcgca aaggaatgcc tgagtgtatg cggagtcagc tctttcttaa 1859341 tgccggcttc caatgcgatt tttttcaggt tcttccaaaa tccctggcgg ctgatctgtt 1859401 tgccgtgatg atttaaaaag agggcgtcag atacattatt ttttaacagt tttcccctgg 1859461 cttttgtcat atattcctca atggcggaag cagcggcttc accgattggc acaatccgtt 1859521 cttttcttcc tttgccgaag catcggataa accccataga taaatgaaca tcagccgttt 1859581 tcaattcaat catttcactg actcgtatgc ctgtcgcata aagcagctcc agcattgctt 1859641 tatcccgata tccgaaaggg ctcgtcagct taggcgtgtc caataaccgc tcgacttcat 1859701 tgagcgcgag caccttcgga agcgcccgtt ccgtcttttg tgtttcgata tgaacggaag 1859761 ggtccttatc cgttactttt tccctgagca gaaattgatg aaaagagcga atggatgcca 1859821 aatgccgcgc cgatgtcttg ccggatttcc ccgagtcctt caaatgcttt aagtattgga 1859881 taatatgtat gcgggtaacg tgattccaat ctgtaacatg aagggtttct gttaagtaga 1859941 gagaatagct tttcaagtca cgttcatagg atacgatcgt attttgagag agccctctct 1860001 ctaccataac gtagtggatg aaatccttta tttgatcttt cactcttgat ctactccccg 1860061 ttttggtaaa aaaagatcaa ccggtcgaac catccgcctt tttcatcctg atccatttca 1860121 acaactttta cagcggagcc ttccggttta tcataccgat gatagttttc atactcttga 1860181 ttcacccata tcatagcata atagaacaaa gcggtaaaac cggtaaacag gatgaaaact 1860241 ttcaatgcat cgacagctgt tttcaggaat cttcccatgt cctaatcgat cctttcccta 1860301 tggttccagt tatataaacc atatgccaaa tcagaaaggt tttatacata gaaacagcaa 1860361 aaaacccttt ccccatgaga aaaggttcgc gctcggcacc gtctattcag tttcttttcc 1860421 gttacagcgg tggcaaatgc cgtgaaacgt caatctatga tctttaatct taaatttcca 1860481 atcacgttca atgatttctt ccacgtcttc aagcaaatct tcttcaattt catcaacggc 1860541 tccgcactcc atgcacacca agtggtgatg aaagtgagct gcgccctctt tccgaaggtc 1860601 gtaacgggac acaccgtctc caaagttaat tttatctacg acttttaatt cagttaataa 1860661 ttcaagcgta cggtatactg tagcgagacc gatctcagga gatttctctt ttacgaggag 1860721 gtatacatct tctgcgctta aatggtcttc ttcgttttca agcagcactc ttactgtcgc 1860781 ttcacgctgt ggcgtaagtt tatagctgga tgagtgcagt tgtttcttaa tacgatcaat 1860841 acggttttcc atgtctttcc ctcctacgcc gcattccatg actcattata acaaaatacg 1860901 cgcagagttc caactataat tattataaac tgataaataa aatggttttc ttttaataat 1860961 gattttaaaa aagtctagat gtaagctttt ccattaaaac aggagataag tatgcttcaa 1861021 agagagatga aatcagcgct aaaaacagaa tgaccagcag cacaaaggca taccgcccga 1861081 accattgaat cggcgcgtca tgcaggcttc gtttcacgaa cagctgtctg attaacttta 1861141 aagaaaacgc aattgcacat gtgcccataa tgagataagc cggaatcagc agcacatttt 1861201 gcggcaaaac ggagacaaat gataggaaaa acccgcttac tcccatctga ttgactagga 1861261 acccgacagt aaagccgacg acgatccctt tcagaaagat cataatgaaa ataatcggca 1861321 tcccaatgac ggaaattccc agtatccaca tcaggcctaa atactttgca ttatgaaaga 1861381 tactttgccc aaacatatca gctgaacttg cctgttttcc atccgaaagc tgtccaaaaa 1861441 attgacttaa gtagtagtat aaatcttctt tctggctgat ggtcatactg ttgacaataa 1861501 tcgcgccaaa gatgacaccc atgaaaaaca gcactgacac aaatatataa agagagagat 1861561 gatctttgac atgcctgaga aacatgtcct tataagagat ttttcgcata ccgtttcctc 1861621 ccgcccgctc tagtgatttg atttaataga ttgtatgaaa gaaacagaaa aacatgccct 1861681 ttttcaaaaa gaaacaatag agatgaatgc taggcggctt tttggggcac aaaaaaatcc 1861741 ttatcatcaa ctgctgtatg atcataagga ttcttatgct tccgtttatt caaaatctct 1861801 tttttgcttt ttgtcattct tccatgtgtg ctgaaagatg gtgtgctgcc tcttgataat 1861861 aagacgtcac gtccgccgtt tctcaatcga tgcccccgct tctttttcgc ttggcttttt 1861921 gccatgtgat cactcccttt tttattttca tagtaatgat aacaaaattg aacaatgata 1861981 agaaaaaaac agcacctgct acgacaggtg ctgtttagct acatttattt cactgctgta 1862041 agagctgcat gctcgacagc tgctgctacc gcatgatgga cttttgaatc aagcggctga 1862101 gggacaacat caccttgttt agtgcaagct gcgatggcct ctgctgctgc gacaagcata 1862161 tcatgattaa tctccgtgct ttttgcgtta agcgctcctc taaaaatccc tggaaaaccg 1862221 agtacattat taacagaacg cccgtcagct gcatatgcgg cgccagcctg cagtgcggcc 1862281 tccggctcaa tttccggctt cggattcgat aaagccagaa tcacttgacc agaacgtaca 1862341 aatgccggtt ttattaaacc cggaacgccc gttgtagcaa tgacaatatc acatgtttcc 1862401 ataagctcct caatactgga aactgcctgt ccgccgtatt gttcgagacg gttcattgct 1862461 gactctgatt tgtctgttcc gtatacagca ttcacaccat aagccatgaa catccggcag 1862521 atggccacgc ctgctgcgcc aaggccgatt tgccccactt tcgcttcctt caggtcaacc 1862581 cccgcactcc tgcatgccga aatggcagct gccagcgtca ctacagctgt accatgctgg 1862641 tcatcgtgca taacagggat gttcagctcc tcttttaggc gatcctcgat ttcaaaacaa 1862701 tgcggcgaac cgatatcctc aagaaggatg ccgctaaagc ccggagaaat atgttttact 1862761 gttttgatga tttcttcagg atcactcgta tcaagcagta tcggaatgcc gctaataccc 1862821 gccagctgat caaataaagc agcctttcct tccatgacag gcatgccagc cacagagccg 1862881 atattcccaa ggcctaaaat tgcggttcca tccgttacaa ttgcaacaga attgctgatc 1862941 gttgtataaa tagaagcttt ttcaggttct ttttcgatca gtcggcacac gtccgcaaca 1863001 cctggtgtgt agacacgtcc cagctctgcc agtgaacgga tcggcatttt gcttttcatt 1863061 tggatttttc cgccttcatg tgcggacagg acttcatcag atacggtgtg aagcctgatc 1863121 ccttctccga gggcctgtac agccgcgatc acttcctgaa gctgttcttc attctccact 1863181 tgaacggtaa tattccgcat tgtgtaattg ggtccgactt ttaccgtctc cacttcacca 1863241 atatccccgc ccagaaggcc gatggccgta gccacccttc caagatttcc gggaaccgaa 1863301 ggcgtttcga tcatcagtgt ccgaatcatg tgtttcgcta tcattcagtg atcctcccct 1863361 attagcctag tttttcggct ttaactgtat tgtttttcgt ataccatata aattttcctg 1863421 tataaccata gataattgca agacctattg ctacaaaact gagccacata aacggcagat 1863481 aagagaaggt agaaacacct aaaataccag ccatgtaaat cccattatca gaccaaggaa 1863541 ccatccccga agtcaatgtt cccccgacct ctgagttacg tgataacact cttctgtcca 1863601 gatgtaagcg atcatagctg tcttccataa ttttcggagt caaaataaga gatacataca 1863661 tcgcacagcc gaagatgttt gctaaaaacg ctacgatcag tgtagacaat gtgacattgc 1863721 cggctgaagt taatttcttt tcaaacgttg aaacaatgac ttttaacacg ccgagtttct 1863781 caagcagacc gccaaaacca aggccaaaga tgatgacgac gagagaatca agcataccga 1863841 caattccacc gcggtttaac aagccgttca aaaattcaac atccgtttta atagagaagc 1863901 cgttgtacgc agttgcaatc gcatgggcaa tatccattcc ttggaaaaca acagcccaga 1863961 ttgcaccgag taaagcgcca attacgataa ctggcataga tggctttttc atcgccaata 1864021 agactatgac gagaactgcc gggatcagca tccaaatatg aatgtcaaac gtgttttgca 1864081 aagatgattt taagaattca actttatcaa gatcaatatt tttcccgccg tacataaatc 1864141 caacaactgt aaagagtata gctgtaatga cataagcagg tattgataaa taaagcattg 1864201 ctctcacgtg agccaataca tcgacttttg atagtgaaga agctagaact gtactgtcag 1864261 acagcggaga cagcttgtcc ccaaaataag cacctgaaag aatagctccc gctactagag 1864321 gaagcggaat gcctaacccc tctccaattg cgatcatggc aatgccggca gttccgactg 1864381 ttccccatga cgttcctgtt gccacagaca taatggaaca aataattaac gttgccagta 1864441 aaaagatact tgggtgaata aattccagtc cgtaataaat caaagtcggc acaacgcctc 1864501 cggcaatcca tgttccgatg agcgccccaa ctgaaacgag aatcagtacg gcttcaaggc 1864561 catttgatat cccatgtaca atcgcatttt gtaaatcttt ataagaataa ccgagtctaa 1864621 tacctaaaag cattgcaata aaccatgaaa caaaaagcgc cagctgtatc ggcaagtcga 1864681 gaaagactgt aaacgataga acaagtgcta aaaatactcc tagtacaata ataatttcaa 1864741 atagtgttgg caatcttaca tccttcaaaa gaagtccccc ttcatgtaaa agctaaaacg 1864801 ctttcaatat atagtgcaac acgtatacta tacttcctca tccctatgtt gtaaacagct 1864861 tattcatccg actattcgga gatgaataag ctgtatttta tacaaatttt atttttctaa 1864921 tagttctttc cctgcgatac ctggtttggt catctcatat gggtttaaaa taatatccaa 1864981 ttcttcttca gtcagcacat catgctgcag acaaagatcc cggacagatt gccctgtcat 1865041 aattgcttcc ctggcaattc tagctgccgc ttcataccca agatgcggat tgacagctgt 1865101 gatcacgcct gcgctttttt ctacgtattg cttcatacgc ttttcgttgg cttcaatgcc 1865161 ttttaagcag ttgtcagtga acgaacggaa gccgttgttc atgatgctga tggattgaag 1865221 caaattaaag acaagcacgg gctccatgac gttcaactca agctggccgg cttctgaagc 1865281 aaggcagatt gtattgtcat ttccgataac ctggaacgca atttggttga tcagctccgc 1865341 cataaccgga ttgactttcc ccggcataat agatgaaccc ggctgacgtg caggcagaga 1865401 aatttccgca agtccggcgc gcggtcccga cgccattaag cgcaggtcgt ttgcgatctt 1865461 cgacatgttc atcatgcaga cttttaatga agctgatacc tctgtatagg catctgtatt 1865521 ttgtgtcgca tcaacaagat gatcagcgcc gacaagagga agcccgctaa tatcagcaag 1865581 gtgctttact acctgtttga tatattcagg atcagcgttc agccctgtac caacagcagt 1865641 tgcgcccatg ttgacttcat acaggtgctg gcgcgattgc ttgattcgtt tgatatcacg 1865701 ctcgagaaca cggctgtaag cttcgaattc ctggccaaga cggatcggaa ccgcatcttg 1865761 aaggtgtgtc cggcccattt taataacaga gtcaaactcc tgtgcttttt gcttaaacac 1865821 actatgcata tcttccattg ttttcagcag tttttctaag agcttcaatg tggaaatatg 1865881 gatagcagtc gggaacacat cgttcgtaga ctgtgacatg ttcacatgtg tgtttggact 1865941 taaatggata taatctccct ttttatgtcc catgatttca agcgcccggt ttccgataac 1866001 ctcattcgcg ttcatgttca tagaagttcc ggcaccgccc tgaatcggat cgacgataaa 1866061 ctgatcgtgc cacttgcctt ccagaatctc gtcagcggct tgtacgatag cttggccaat 1866121 tccttcatac agccgtttca cgtccatgtt ggcaagagcc gcagcttttt tcacaatcgc 1866181 cagtgcgtta atcatttcct catggatttt gtatcctgtg atcggaaaat tttcagaagc 1866241 acggagcgtc tgaattccgt aataaacatc tgcttcaatt tgtttttccc caaggaagtc 1866301 tttttccacg cgatattctt tttggccgtt taacataatc tttaaccttc tttctctttg 1866361 ctggttatcg tttttacatt ttacaggaca acgtcatcag ctatcggcgt ttccataatt 1866421 ctcttgacga caggaagatc cgaagactga cctagcgccc acatcaattt tggcacaatt 1866481 gcttctgtgt tcatatttct tgatcggata attaagtctt ggttgactct gcggccaacc 1866541 tcgtaaatgc tcatgtcttc gccttcttca agacattgag tcgtaatgac gacgacaatg 1866601 ccgctttcga tcagttcatt cacttttgac aaaatgtctc tgccttcaaa cggcactcct 1866661 ccgctgccat aactctcaat gacaattcct ttgtacatgc ttttcagggc atcaaacatt 1866721 tcgggcttta agcctggatg cagcttcagc agacatacat ctgtgcatag tgaagtgtca 1866781 actgtgaagg tgtcgttctc aggttccgtt acttgtttgt tgtattcgat cccgtcttca 1866841 ttgataaaag cgatatatgg gtaattgatg ctttcaaatg cgtcgtagct tttcgttctt 1866901 aatttgatcg cacgcgttcc ctgaatgact ctgccgtcaa acacaacata aacgccgccc 1866961 acgccttcac aggcaaatcg aatggcatct gtaatatttt ttttggcatc ggttttttgg 1867021 aacgtgatcg gaatctgcga gccggtgatg acaatcggct ttttggcatg ctgcagcata 1867081 tacgatagtg cggcagatgt ataggccatt gtatctgtac cgtgagtaat aacaaacccg 1867141 tcataggcat cataattttc cttaacggct tctgctattt ccacccagta ttcaggctgc 1867201 atattggtgc tgtctatatt cataagcgac tgagtttcca ttgtgtaatc gttatcaagt 1867261 tttgatacgt aacttaataa ttcatcagcc ttgactccgg gagccagccc attttcccct 1867321 tcaactgaag caatcgttcc cccagttgtc aacatcaata attttttcat accatgcacc 1867381 tcttcactgt atctaaagat gggttgcgag aaggtattcg cttttcgcat acttttaatg 1867441 caattataga cacggaaaat aaaatacgca agacattatt attcaattcg cgtacacttc 1867501 ctaataccta tatgatataa tcagctcaag gtgaaaaagg agcggaagtt catgaatcta 1867561 gatcgtttaa ctgaattgag aaaaaagaaa aattggtcgc ttcaatatac agctgacctt 1867621 ctcggtatcg caaaaagcac atatgccggc tacgagtcag gctaccgacg gccttcactt 1867681 gaagcgcttg ccatgctggc tgacctcttt gacacaacct gcgatgaact tttaggccgc 1867741 gagaaacaaa agcagactgc tcctcaggcc atagaattgg ccacgtggag cagcctcgac 1867801 tttaccattt ctgttgatgg ccagccgctg agtgaagatg aaatcatcca gctgattacc 1867861 tttatacgca caaaaagaaa agtacaggag gaactgagtt aatctttagc tcacggttta 1867921 attttaccgt aggttcctcc tcctccggct ttcaattcca gttttccgga tctcgctttt 1867981 acgataagcg ccgcggtttt cggcgggaca acgcgagcca aatcttcttc tgcagcctca 1868041 tgaagaacag ccatttctgt tccgaaggct ttttttagtt tgtccagcgt tttcgggcct 1868101 acacccggaa caaattgcag cgggatctga tgtacatatc gcggacgcgg gacgcgaact 1868161 tcaagctgat cactcaattc acgcaatcta tcgctgactc ccttggtaaa tctggctttt 1868221 ccgcaattcg cgcacgctgt ttccccgctt acagcaggct ctccgcacgc ttcgcaagcc 1868281 gtctgataat atttccccaa taacgggtcc aagccataat ttgcgataat tttcctgtca 1868341 tcttgtccct ttaatgcaag agcaaattca gtaaaatcag ctgactgcac atataattca 1868401 ttatattctc tgccgatttt ccccaacgaa tgcgcatcag aatttgttaa aaaaggatac 1868461 ggattcaatt gcgatacgtg tgatgccatg tctgtatcac agcttaatcc aagctccacc 1868521 gcgtctatca tagatggatc aaaaacctca gttaagcttg atttaacccc ttttccatat 1868581 aagcttttat gcggcgtaaa gatatgggcg gggataaaca ggccgcccat atcctgcact 1868641 tttttttgca ggtttaagcc cgtttcataa atccgctgcg agcttaaatg aatatttttc 1868701 agccgggctg acagccagtt tgaaaactgt ttcatatcag ccagcgtcgg cataaatacg 1868761 agcacatgga tcggtccgct gcaggcttca tcataaatct ccagctcgct ccccaataaa 1868821 agagtcgtgc tgcgataacg gattcctccc ccgtcaagct cgcgatattt tccagatgaa 1868881 atgccttcct caagctctag aatgacttcc ggagaatgac agtcgataat gccgaggagt 1868941 tcaattcctt tatgttcact ggcttcaacc aaaattctgt ccagcgttaa tgttttggcg 1869001 cctgttattt tgacagccct tcctgtaaag gtccggccga tatgaatgtg caaatccgcg 1869061 taaatctttt tcatttttgt gcttggagcg cttctttcag ctgaagatac tgaatcgcgt 1869121 aggctgtttt agcatcatat acttcacgcg attcaaccag ctttagcgca tcttcaagcg 1869181 tcacctccat cacttcaaca aactcgtcct catcaagctc ccgtttttct tcaagcacag 1869241 aaagctcctc agcaagaaaa acgtgaacga tttcatctgc aaatccgggt gatgtataaa 1869301 acgcagttat ttttgtcagt ttttttgctg tataaccggt ttcctcttca agttcccgaa 1869361 gtgccgtata ctccggctcc tcaccttttt caagcttacc ggccggaatt tcaacgatcg 1869421 tccgctcaag cggcttacgg aattgtttga ccatgatgat tttcccttca tctgtgacgg 1869481 ctagtaccgc tacagctcca gggtgtttca caatttcacg tttactggct ttgccgtttg 1869541 gcagctctac atcctcgaca taaagatcaa tgactttacc cgaaaaaatc tgttctttgg 1869601 caattgtttt ttcttctaat gatttcattt cttcatctcc cgttctgtct ctatatgatg 1869661 ccccatacat tttatcatac tagagcaaaa gggggcttct tcgtgaaagt gcaccgcatg 1869721 ccaaaaggtg ttgtcttagt cggaaaagca tgggaaattc gagcgaagtt aaaagagtat 1869781 ggacgcacat ttcaatatgt gaaagattgg atctcaaagc cataaaagtt gaaactttag 1869841 ctcctttata ttacggtcaa tacaaagcct aaaaaaggag tgtgcacatg agaaagcgca 1869901 aattgggtac atctgattta gacattagcg aagtcggact cggctgtatg tctcttggaa 1869961 ctgaaaaaaa caaagcattg tccattctgg atgaagcgat cgagcttggc atcaactatt 1870021 tggacacagc ggatttgtat gaccggggac gcaatgaaga aattgtcggt gatgcgatcc 1870081 aaaacagacg ccatgatatt attctggcaa caaaagcggg aaaccgttgg gatgacggaa 1870141 gcgagggctg gtattgggac ccttcaaaag cttacataaa agaggcggta aaaaagagcc 1870201 ttacacgtct gaaaacagat tatatcgacc tttatcagct ccacggcggc acgatagagg 1870261 acaacattga tgaaacgatt gaagcgtttg aggaattaaa acaagaaggt gtcatccgct 1870321 actacggcat ttcttccatc cgcccgaatg tgattaaaga atatgtaaaa aaatcaaaca 1870381 tcgtcagcat tatgatgcaa ttcagcctgt ttgacagacg ccctgaggaa tggctcccgc 1870441 ttttagagga acatcaaatc agcgtagtcg ccagaggtcc tgttgccaaa gggctcttaa 1870501 ctgaaaaacc gcttgatcaa gcttcagaaa gtatgaaaca aaacgggtac ttgtcctatt 1870561 cattcgagga actgacaaat gcccgtaagg caatggagga agtggctccc gatctttcca 1870621 tgacagaaaa gtcgctgcag tatctgctag cacagccggc tgtcgcttca gtgattacag 1870681 gcgccagtaa gattgagcag ttacgggaaa atattcaggc agcaaatgca cggcgtttaa 1870741 ccgaagagga aatcaaagcg ctccaatctc atacgaaaca agacatttac aaagctcatc 1870801 gctcatagca gaaaaaccag cacctgtacg ggtgctggtt tatttatatt gatgccaatc 1870861 catttggctt tcatttagga gttcttcaaa gctcttattt ttttcgatct cttttttctt 1870921 tctaatctgt tctgcttttt ctcttttctg cctcttttca tcctcttcct tcaattggct 1870981 cttcatctcc ataagctttg ctttgatatc ggattgaagg ccgtctttta gctggtgttt 1871041 gtcaatggat ttttgttttt tcatgcagac ttcccccatg ttttgttttg aagccagttt 1871101 atcacggagc atataaactg aacaagcaga ctctcttctg atcactttct cagcgtagca 1871161 gtgtttaggt ataatgatct taaacacgaa ttgcctatat atttcgttga aaggtgctgt 1871221 gacttttgaa gaaaatcctt ttggccattg gcgcgctcgt aacagctgtc atcgcaatcg 1871281 gaattgtttt ttcacatatg attctattca tcaagaaaaa aacggatgaa gacattatca 1871341 aaagagagac agacaacgga catgatgtgt ttgaatcatt tgaacaaatg gagaaaaccg 1871401 cttttgtgat accctccgct tacgggtacg acataaaagg ataccatgtc gcaccgcatg 1871461 acacaccaaa taccatcatc atctgccacg gggtgacgat gaatgtactg aattctctta 1871521 agtatatgca tttatttcta gatctcggct ggaatgtgct catttatgac catcgccggc 1871581 atggccaaag cggcggaaag acgaccagct acgggtttta cgaaaaggat gatctcaata 1871641 aggttgtcag cttgctcaaa aacaaaacaa atcatcgcgg attgatcgga attcatggtg 1871701 agtcgatggg ggccgtgacc gccctgcttt atgctggtgc acactgcagc gatggcgctg 1871761 atttttatat tgccgattgt ccgttcgcat gttttgatga acagcttgcc tatcggctga 1871821 gagcggaata caggctcccg tcttggcccc tgcttcctat cgccgacttc tttttgaagc 1871881 tgaggggagg ctatcgcgca cgtgaagtat ctccgcttgc tgtcattgat aaaattgaaa 1871941 agccggtcct ctttattcac agtaaggatg atgactacat tcctgtttct tcaaccgagc 1872001 ggctttatga aaagaaacgc ggtccgaaag cgctgtacat tgccgagaac ggtgaacacg 1872061 ccatgtcata taccaaaaat cggcatacgt accgaaaaac agtgcaggag tttttagaca 1872121 acatgaatga ttcaacagaa taaaaaagcg aaaggcctct tcggctcttt cgctttttta 1872181 tgttacagaa cgtcggtaat gccatccata ttttctctga tccattcaat cgcaagatct 1872241 atcgttgtaa actcctgcgt ctcgaaggtc atttcatcct gcaatagcca gacatctttc 1872301 ttgatggact ctgctcctcc gattgaccag tgaagcaagg tataaggatg gttttgattc 1872361 aggaaggata cccacgtttt attttgtgct gtgttcttca ttgccttcag cttttgttcc 1872421 acgtttcgcg tctcctactt tactaatatg ctcattctgg ggctgagcat ttcagccggg 1872481 cttttcagcg ccaatgtttt ggctttttca ttgtaatcga tcgtcatttg atcgtcaaaa 1872541 aacacttttt gcgacgattg gatatacagc ggaatgccgt tcgtttccag ctgctcgcac 1872601 tgtcccgtta attcttctgc cagccagatt gtcgggacac cgcttaccgc gcagccgcat 1872661 ccttctgcat cgtaacgaag ctgggctttt tttcccgggt tggcgtcaaa cgcctgctgc 1872721 agtgcctgtt ttgctgcatc tgtcacatgt atgttcataa ggtgaaaccc ccgttttcat 1872781 cattttcgct attgtagcat acaatactgc cattcgcatt gtttctgcct tttttccacc 1872841 gcttcgcatt ttcttctgca gtcttgatcc actcatcttt cccttgtata tactgattga 1872901 tgctgtcagg gtgctgggcc gccagctgtt ttttgagaac ggcgtattct ttcgctatgt 1872961 ttggatgagc tctgagataa tctctgaata acagatgcct ttcaatagca gggtttccct 1873021 gttcgtacat atggacatga tgagtgcgtt tatttccgcc cttttggaaa taacgcctgc 1873081 ccgctatacc gttctcacct tttggtgtat agccgttggc cttcatttgt tcatcaaatt 1873141 ggctcacggc ttcaatgctt ctgacttcaa ttaacatatc aatgattggc ttcgctgcca 1873201 tgttaggtat tgatgtgctt ccgatgtgat gaatagcgat aatctccggc ccgaacacaa 1873261 gtttcagccg ttctttttct tcatcgaaac attctgccca tttttcgttg tagagaatga 1873321 tctcaacttt tcttttcgga tacaaatgaa agaccgacag caatagaccc tgcgctgctt 1873381 tgacggtttc tgccttttgg aatccggcct gtgtatagag tgacacagcc ggggtattgt 1873441 tctcggctgt gactacttcg attttctcag cgtcttcatt atgatcaatg acaaattgca 1873501 gaagcgctcg tccaattcct tttctgaaac cgtcaggatg cacaacaagc ctgcaaatgg 1873561 tgagataatg catgtttttc tcatatgaaa tgacaccgat cagcttgccg tttttccgat 1873621 atcccgcaaa ccgttcatgg gatgcttgaa tatcctttac cttctcttgt aaagcgggaa 1873681 taccgtcaaa accgataatc tctgtttcct ttatgtaggc ggggatctgt acggctaaaa 1873741 tctcacgcgc tatagtggct tccttatgct ggagaaattc aatcattcgt gttctcctga 1873801 aacagccgct gtctgtcgac ttttgcgacg cggactgcat acgactcgta ccaaacgctt 1873861 cttccttttt cttttgctgc ttgatgttca gtgtgatgcc tccaatggtt aattgcgtcc 1873921 atactgtccc aataggaaac tgtgatgccc cttccatccg cttcacgtac gctttccacg 1873981 cctaaaaatc caggctgatc cgccgcaagt gataccatcc gctccgctgt ttctccatat 1874041 cctgtgtcat tttcgctttt gacagaagaa aaaatgactg catagtaagg aggctcaggt 1874101 gtttttgata aaaaatccat catatttccc cctcatatgt ttttgacaaa tagtaccctg 1874161 tcttggcccg ggccatcata gtttgcaaac actgagatgc catttaccgt tttggtgccc 1874221 ttttcaatat caaaccccaa ttttgtgtga tatgcgattg ataccttatt cacaggtgaa 1874281 gtgacacact tcacccgggt gcagcccctt tgttttactg tttcgataaa tacatcatac 1874341 aattgtttcc caatttgcat ttttctgaaa tccggatgca caccggaaaa atgaatgtac 1874401 gccgtttcag gatcggattg cgattgaaat ccgattaaaa atcccgtcat gctgttatgt 1874461 tcggatgtaa taaagcttgt gtcctgaaaa tgctcaaaaa atagtctcgg caatttttct 1874521 ttcagctgtc tgccgcccca ccattcattc agtacagacg ttaccatttc ataatctgaa 1874581 gacgtgattg ttcgaatatc cattacgatt tgatctccct ccgtctggca aaacgaatgt 1874641 cagctctttt tctcacaata taaaaattat attttgcctg gctggaattg taaatgcctt 1874701 ctttcctgta tcatacgttt ccagactgcc gagggaacaa tgtttgatca ttttacgcct 1874761 atttctcccc caaacaggag gagagacttt acagcacaat atcaagcact tgatcaagtt 1874821 tcagcttata aagctgatcc tcgtctcctt ttatccatac tgctttttca aactcttcat 1874881 accggcagat tttcccggtg cagcagacaa tctcaccgtc ctgaaagcag ctgacagtga 1874941 tatcctgagc aaactccatc gcggcgcaaa gcgtttgatt catctcttcc agcttatcgg 1875001 ggtcaaggat cggcttttgc agcttctgtt taagtcgctt tctctccagc aggctttgct 1875061 tatgttccgg cagaaacatc ctgctccctt cccacagcag gttgcccctt tttaaatggt 1875121 cgttcattta taatgccccc ctattttagc cgcacgttca aatgcctggc ctgccgctgt 1875181 cagtgacgcc gccctgatga ttgctgtatc gccgaatcga tttttaatgc catccatcac 1875241 atagcctagg ctcattttct ttgcataatc ctgaaataaa ttgagctgcc atatgtcatc 1875301 agatgagagc tgagacagat tgacaccgag gcggcggacg ggtttcccgt cccaaaatgt 1875361 aagaaacagc cgtcgtacag cctcatatac atcctgcgta gaattagtcg gctctgccag 1875421 cttcacttgc cggttgaagc ccgtcggcca atcaaaatca gcaccccggc agctcactga 1875481 cactgtctgc cccatgaccc cggcgtttcg gcttcgcctg cacacctctt cactcagctc 1875541 aagcaatacg accttgattt ctttgtcaaa gtgttcgtag tctctcggga gagtcattcc 1875601 atgacctatc gccttttgcc cgtccagaga cgaagttgac acaggggaat agtcgattcc 1875661 gtttgccgtc atccacagca cgtggccgtt aatgccccat ttctttttta aaagatcgag 1875721 cggaaaagcc gcgagcccgc cgatcgtgct gatgcccatt cgatttaaat gatgcttcat 1875781 gcggctcccg acgccaaaca tgctgcccac cgggagcggc cacatttcgg ttttcatatt 1875841 ttctttcgtt aaggtaaaaa taccgttctt attctttttg gcaaaattgt cacacgcaat 1875901 tttggccagc gctttgttag ggccgattcc gacccgtgca taaacgccga tctcccgcat 1875961 gattctgccc tgaatgcttt tcgcgatctc catcggcgtc ccaaacagct tctggctgcc 1876021 tgtaatgtcc atgaactgtt catcgatgga atacggctcc acaaggtctg tatactcctc 1876081 gagaatggcc gtaatttgca gtgatacatc aatataccgc tgcatacgcg gccggagcac 1876141 aacagcctca ggacactttt cctgcgcctc ccacagccgt gaagcattca ccacaccctt 1876201 ttgtttcgcc agcgggcagg cagccaatac gactccgccc cttttttcag ggtcacccga 1876261 aacaatgacg ggcctatttt tcaaatgtgg attttccgct ttctctacag atgcataaaa 1876321 cgattgcatg tcaacgagaa aaatcacttt ttctttcatc atacacacct ctaaaaagaa 1876381 cttatgttcg cttttcatta tatgcgaaag tatgttcgtt ttatactggt aaatgattct 1876441 tgtctgacag aaaatatgat ccaagggttt gagagaagaa aaacatttag tagaataaaa 1876501 gcgaagcata aggataggag agtcatgatg gagaaatttg tcgaaaaaat gctgggacag 1876561 gcattgcggc aatacggcag aaacgttgct atagatccgt taagcccgta tgaaaaacaa 1876621 agcctgaaag cggctctaca agagagacgg aatgaagaac cagatgagga tttgcatgcg 1876681 catatagaag atatcattta tgactatgtc acaaaccaag gcctgttctc ttaaacgcat 1876741 gactgtcagt tctttcagcc gctgatgcgg cttccctttg aaaacaccgc ctgaaacaaa 1876801 taaacagtct caggcttaca gaaaaaaagc aggattttct cacgctccat agattcatat 1876861 ggcctggcgt aaaattcccc tcaatgctcg cgcaaaacgg aataagctgt ccatgatcac 1876921 gcgtatacac tttttcgaag agatgtgctc tcttgttctg tcatgcggtc catgccggtt 1876981 ttcagcgtac atcttgatct catagccggt ttcactgccg atatgatcca cgttctggcg 1877041 gcttaaacta acacaccctc actgaccaat cgctttgctt ttcatcggac atcccgtcat 1877101 tttccttctt tcaagatgta aactccgtca gccacacgca tcctcaacgc atagtatatt 1877161 gccatccata caatcaggca tactacatgt caataacgaa atattttgaa cgatctattg 1877221 gagaaggaaa ttttttcata tatgatagag aaagatcata catacaggag agaatataat 1877281 tcatgaagaa atggaaagat atccacccga tcagctggac aattataatc ggaaccattt 1877341 tcggcagaat ggcaacatcg atgagcattc cttttttagc gatttatttg acagccgtcc 1877401 aaggcgcatc agcttcctat gcagggctgg tcatcgccgc gagctcatca gtcggcatcc 1877461 tcgcaagctt ttacggcgga tatatctcag ataaattcgg cagaaaaaac atgatgcttg 1877521 tatcgatttt cggatggatg ctggtatttg caggctttgc ggcagcatct aatctctggg 1877581 tgttttttgt agtaaacgca ttaaacggtc tttgcaaatc actgtttgag cccgcttcaa 1877641 aggccttgtt gtctgatatg acagaagaaa aaacgagact gctagttttt aatttacgct 1877701 atgcggctat taatatcggc gttgtcttcg gacctgtgct tggcctatat ttcggctcat 1877761 cgcaatcgac tacgcccttt ttggtgcctg cagtcattta cggactatac ggaattgtgc 1877821 ttgccctcca atttaaaaaa catccatcct tatcagcacc agcccagtcc cgaaatatga 1877881 gcgtgcggga agcgtttatg gtcacgcaaa aggattatct ttttaccatt gctttggtcg 1877941 gcattacgct atgcaccttc ggctactcac aattcagttc cacattccct cagtatatgg 1878001 cgcagaaccc cttgatcggc aatggaacga agctgtatgg gctgatgctg acattaaacg 1878061 caatcgttgt gttggcgacg caatttccca ttgtccattt tgcaaaacgg ttttcgccgc 1878121 tttgttctct gatgctcggt aatgtgatgg ttagcatcag catggccatt ttcaccgtat 1878181 cacacggtgt tccatcaatt gtgatgattg tcatcacatt tacaatcggc gaagtgcttt 1878241 tattctctat gatggatttg tatgtagacc agattgcaaa accaggatta aaaggcactt 1878301 atttcggggc aatcggtttt tcacagctcg gaaacgtcat cggcccttgg gtcgggggga 1878361 tatgtataga cctgtttggc gctggccggc cgatttatat tttttctgtc ctgagcggca 1878421 ttaccctgct cggcctgcca tttttagcgt tcgcctatcg gcaaatgaaa atggagacca 1878481 caaaacaccg ttcccgtctg gaaaagccgc tttaaataaa aaacggaaga gaatgaatct 1878541 ctcccgcaaa catgaggtga agaacatgaa tataggtgat gtgatgtttc agctgtttgt 1878601 atttattata tttgccgctg tcgtctttgc ggctgttaca ggcttcaagt atgcgaaaaa 1878661 ccgaaaagcg cagctggatc gcattgagaa aaagctgaac agcctgtccg aagatcacga 1878721 ttaacagctt ggggcaacga gctctacctt aatccggtct ggatcctcac aaaagactgc 1878781 ataatgcccg tctcctccgg caaaaggatg cctgtctcgg tacaacacac gatagccttt 1878841 tgccgtcaat ttttcagtca tctgatcgac ttgaagcttg gattcagcat gaaatgcgag 1878901 atggttcaga ccgactcggc atctatggta ttccggctct agaaatggct ctttcgcctg 1878961 cacaatcact aggtaaaaac gatctttctt ccagctgatg cctgagctcc atttttgata 1879021 ctctttataa ccaagttctt ttaagaacca gccccaaaac cgcctagacg cctccaaatc 1879081 agagacatac agttcaatat gatgcacatt tcataccctc cttaccaaca cttcctcgac 1879141 cttatgcccg tctcccttac gcaaaatgag atctgacctg aatttagttg gcaaaatatt 1879201 ttcatataaa ttcggccggt tgacactctc ccaaatcgag gctgccatct cgtcagcctc 1879261 ctgatcggac aagtctttaa atttatgaaa atatgaatca ggattttgaa aagctgtttc 1879321 ccgaagcagg cgaaaacgct ctaaatacca agtgaaaatc cggctttcct ccgcatccac 1879381 ataaatcgaa aaatcaaaga aatcggaaac aaaaatacgc gggttttccc ggtcatcctc 1879441 caaggtgggc gactgaagaa cattaatgcc ttcaataatc acaatatccg cctgttctac 1879501 aacctcgaac acaccttcct cgcggtcata ggttagatgg gaatacaccg gggcctttac 1879561 gctgtccttt cctgatttta agtcattcaa aaattcgagc agcgccttta catcatagct 1879621 ttcaggaaat ccttttcttg acatcatatt tttctttttc agctcggcag taggaaataa 1879681 aaaaccatct gtcgtgataa ggctcacttt tggacggtca ggcaaacgcg aaagcagctt 1879741 ctgcaagatc cgcgccgtcg tgctttttcc gactgcgaca ctgccggcaa tgccgataat 1879801 aaacggaatt ttggctgaat gtgggtgctt caaaaaaaca ttgacatgct tattgcgttc 1879861 agccgcagac ttgacatgta aatgaagcaa gcgaacaagc ggaatataga tcgtctccac 1879921 ttcttcaaca gatagataat cattcaatcc ttccacagct tttgcctctt cttcagatac 1879981 agcaatcgac aaatgccccc caaaaccaga ccaagactcc cgattgtgct gtgtatataa 1880041 agtatgtagg ttaagttctt tatttttcac tgtttacacc tgactctctg taggttaaaa 1880101 cccttacaaa gattgtaacg gaaaaccttt tcactgtctg cttatttttc atttcgtttt 1880161 tttagcaaat cagcaccgat tcggttatac gcagccattt catcttttgg aaccatgctt 1880221 cctcccgttc cccagacgac atgtacggca tgttccatct tatatttctg agcatagcgc 1880281 cttccctctt ctgtcgaaaa aagctgaacc ggcccgaaca tgccagcaag agcagagggc 1880341 tctaaatatt tatcttcaga tacagccagc atatgaagca aagtataaag cgtattgtcc 1880401 tctaccgtat aacagccgct cagaagcggt tcaatcagct tgccgacaaa tcctgacggc 1880461 ctccctacgg caagtccgtc agcagccgtc tgattatcca ggccgatatc ctggacggag 1880521 atcttctcgt gaagtcctga ataaagccct aacagcatac aaggtgaatg agttggttct 1880581 gcgaaaaaca catgaacatc atctccgtat aaaagcttca gcccaaatgc tacaccgccc 1880641 ggtcctccgc cgactccgca cggcagatac acaaacaagg gcgtctcaag acttggcttt 1880701 atattcatac agtcaagctg tgtttttaat cggcttgcag caacagcata tcctaagaac 1880761 agctgacgag aatgttcatc atcaataaaa taacagaatg gatcttgttc cgcctgccgt 1880821 ctcccttcgt tcaccgcttc actgtaatct gtttcgtact ccataacagt gactcccttt 1880881 tggcggagga gatccttttt ccactgctta gcatcggcgg acatatgcac tgtcacgcga 1880941 aacccgagtg ccgcgccgat gatgccgatg cttaaaccta gatttcctgt cgaaccgaca 1881001 gcaatcgaat agcgggagaa aaacccggta aaccgctctt cctgtaagat gcggtaatca 1881061 tcggtttcct gaagcattcc ttcttgaagc gcgagatttt cagcatactt taacacttca 1881121 taaatcccgc ccctcgcttt aatcgatcct gaaatcggaa gctcatggtc gcactttaaa 1881181 agccatcttc cgggaaatgg ctgctgatat gccgcttcca gctttccctt catatgctgc 1881241 acctcaaaaa gcggagactc gatgattcct ttagcgcctt tcgtctcagg aaacacctcg 1881301 gcaatgtaag gtgcaaaccg ctgcattctt ttttccgctt ccgctatctc ggttgcccac 1881361 tcatctgcac ggggtaatgg cccctctttc ttgcctgaat ttgcccagaa tacaggctct 1881421 gcatcaatca gtttctgaat aaacggatct ttaagcagag catgaaggac ttctgaatga 1881481 actgacattc aacaatctct cccttccact atcaaaaact gccccgtgag aaacaagcca 1881541 ctccaccaca ggcagttcta tcattatttt ttcatgagcg cgcgtcctgc cagcttttct 1881601 acaagagctg gaaacagctg atacagctta gtgccggcat tcattaaacg cggaagattg 1881661 atctcccgct ttttcgtaaa aattgcagct gtaatttgag ctgccacgtc atcaggatca 1881721 agcatccagc ggccgacatt tttggcgtag tccccgcctt tatcagcaat ggaaaaaaag 1881781 tccgtctgaa tcgggcccgg gttgactgtt gtcacataaa tgccggttcc cgaaagctcc 1881841 atccgcaaag cgtttgagta acctaacacg gcatgtttgg tcgcggaata caggctagac 1881901 ttcggtgtgg cgattttccc cgcttgagag gcgatattga tgatatgtcc ctttttttgc 1881961 tcaagcattt gcggaagcac cgcttttgta caggcgatca ggccgaagac attcacatca 1882021 aacatcgctt tcatgtcatc caatgtagag tctaaaaccg tttcaaatat accgaagcct 1882081 gcattgttaa tcagtacatc aatcgagccg atctgatcgc ggacccgggc gatatcctct 1882141 aggcggccga catccagagg aaaaatctca cactgtccgc tccattcctc ggttattttc 1882201 cttttgattt ctatcaaacg atcctcgcgt ctagccgaca gcaggacatg ggctccttca 1882261 gccgcgcata agtatgcgat tctttctcca agccctcctg aagcgccggt tatccaaatc 1882321 ctttttcccg ctatatgttt cacccatttc acctcttcat tgttttaaag tatacggtat 1882381 ttccttccca atatgacgtg atggcttctt cagcctccaa cacatcaagg tgacctgccg 1882441 tttctgacat cgttaaaaac aattcctttt catatacagc aggaaaaagc tgctgacaga 1882501 cctgaaaagc ggtcatcggc ttttcatcca gcatgcgacg cacatcctcc gtcctgttcc 1882561 tctgcttgtc aaaacgcttc tcaatcagcg cttgtacact ggtgataggc tcgccgtgac 1882621 caggaaatac gattgttgga tcaagttgag acagccttcg caatgaccgc tgataatcca 1882681 ctaaaggctt tgacctgacg tctcccgctt tcggcgcttc caaaatcgga ttagacgagc 1882741 tgtttgccag cagtagatcg ccgccaagca tccttccgct tttttcatgg aacagaacaa 1882801 tatgcgattc agcatgtcca ggcatctcca acacagacca gccctcaagc ccatctatgc 1882861 ccataccttc tctgattgat tttgtcagag atctcgtaca ggaaaatgcg tacgctgatc 1882921 gaatcagctt ttccgccttc cccgtatcaa atggaacgcc taattcaggc agcagctttt 1882981 gaaaaaaacg tttttgccaa tccataaagg cttgattttg gctgatataa ggttcgttga 1883041 atgtatgccc aatcacttcg atttcatctg aaaagacatc aagcaagcct gcatgatcag 1883101 catgatggtg agtcagtaca acctgctcga tatctgacaa tttcacattt acagcggcaa 1883161 gctgctcttg taaggctctg gcagcctctt ttgtattcgg cccggcatcg ataagtgtca 1883221 gcgcatcacc ttttacgagg taaacgataa catcgccgac agcaaacggt gtcgggacgc 1883281 ggatcgcaat tacatcttca gttgtcatcc tttcgctcct tgtcttcatt cattattcat 1883341 attttagctt tttctcggtc ttgtgtcatt attgcagaat gagaacaaac ctttttgaaa 1883401 aagctattga cattagcttg tccgccattg cataatgaac aacaaactaa aacgagaacc 1883461 attggaacgc tatgacgagg aatagtatac aaggcaatgg cctaagagag cgataccccc 1883521 ggctgaaagg tgttgcggcc cgcttgtttg tagaacctgc cctcaagtcg cggttaggaa 1883581 aacctaaacg tttcccgcgt tacggggatt tgagctgagc acaatttgtg ctaatgaggg 1883641 tggtaccgcg aaccttttcg tcctttacgt gatgaaaagg ttttttgttg ttctaataga 1883701 aggaggatat caatgaaaaa gataggattt gtcggcgccg ggtcaatggc agaagcaatg 1883761 atcaacggca ttttgcaaag cggcatcaca aaaccagaac atatctatat tacaaatcgc 1883821 tcaaatgacg agcgtctgat tgaattaaag gaaacgtaca gcgtgcgtcc atgcagagat 1883881 aaaaatgagt ttttcactca caccgatatc attatcctcg ctttcaaacc gaaagacgcg 1883941 gcggaaagca tcgacagcat ccggccgtat atcaaggacc agcttgtcat ttcagtactt 1884001 gcaggcctta ccatcgaaac cattcagcat tattttggca gaaagctcgc ggtcattcgc 1884061 gtcatgccta atacatcagc ggcaatcaga aaatcagcaa ccggattttc cgtaagcacg 1884121 gaagcaagca agaatgatat tattgccgca aaagctctat tggaaacaat cggtgatgca 1884181 acactggttg aggagcggca tcttgacgct gtcactgcaa tcgcaggcag cggcccggcc 1884241 tatgtgtatc gttatattga ggcgatggaa aaagcagcac aaaaagtagg attagataaa 1884301 gaaacggcaa aagcactcat tttgcagaca atggcagggg caacagatat gctcctccaa 1884361 agcggcaaac agccggaaaa gctgcgtaaa gaaatcacca gtcctggggg cactacagag 1884421 gcaggtcttc gcgctttaca ggactcccgc tttgaagaag caattattca ctgtattgaa 1884481 gaaacagcta aacggagcgc agaaatcaaa gaacagtttg ccggtgccgc cttagagaga 1884541 cattcttaga tgtaaggaca aaaacagaag gcacagtgcc ttctgttttt tatttttccc 1884601 gcagcagctg gccggcagat tctgattgct ttaatagcgc ggagatcgta aatgaaagca 1884661 aatcgggaag cacttcaaag gaataaggca tatacaatct ttccgtccat ttatgcgggt 1884721 ctttaccagc cggaccgaca tttaaaactg ggacatataa agcctgattt ttaccgcttg 1884781 gcaatgaata ccctctgtta aagagcggca tattgcttgt gtatgcatca acctcctgtt 1884841 tttccagctg aagataactc aagtccgaaa gtccggggaa gtactgaacc tcccgtaatg 1884901 caatgccgta tcgctcagcc gcataatgct ttatctgatc tgctgtattt ctgatcaatt 1884961 gatcatcctt tgaagaaaca gctggataaa gcggcggact ataaaacaga acgatgagcg 1885021 gcgcatcctc cttacaaagc gaagcaagct cagaaacaat tttcgtcgaa aaatccctgt 1885081 ctccaagctc ccccctgtta gcaaaggcat aatttagagc ccgctctgtt tccgagatcc 1885141 ccgcacgctt ttttgcacgc gagaccagct catcaaatgt caaaacagtg acgtcccgct 1885201 caatcggctg aaatggctca aattgttgaa aatcctgtgt tttcttccga acgttcgaca 1885261 tgatttcctc cgccgcctgt tctgctgttt taagcagcat ctgatgcagc tcactagctg 1885321 agcgtttcat tgacagcaca ttaaataatg tgacggctgt atgcggtgtc tggactgaat 1885381 atgcctcttt caagtccttt tgcattaagt ttaccggcgg cggagtgacc tcgccatcaa 1885441 ccttttcgca ataatcagca ttcagttcaa gcaaacggtt aatctcagat accattaaat 1885501 ttgcgtttag acctgaaaac ggctctccaa catgtgtctc aatccccttg cagaaaaaac 1885561 ccgcaagcac cttgccaatg cttcctgtat aaaaatattg ctgctgatcg ccgggaaatt 1885621 tttcaaacat cggttcggca ttcaggcaag cggttaatgt gatatcatgc tttttctcca 1885681 tctccttcaa tgcaggaacc gcttcaatca tgcctcttga attcacttcc tcgtccggaa 1885741 ccgttatcaa cagcagattg ccctcaaaat gcccgttcat tgccctctcc agcatcgaca 1885801 gttgaataca aagccccgct ttcatatcca tcgtccctct tccgaacagc cagtctccgc 1885861 tttcggcatc tcttctcaca cgttccggga gcagctcttt tttctctaaa aaggagctca 1885921 aaagctcagc aggcttgcaa gccatatgtt taaattcgcc gtaatcttct atgtcaacga 1885981 catcaaaatg actcagcaga agcactgtct ttttgacatt cttctttttg actagagccg 1886041 taagaaaaga tctgccatcg tccatcggat gaagtgttac atcatcaggg tgcttttgaa 1886101 aatagggctt gtccttcaaa ataaaataaa gatactctgc aagcgctacc tcgccctttg 1886161 aaccggtgat gctttcgtat tgcacaagag aagttaaaag tgccagcaat tcgtccttcg 1886221 tctgccaatt cattgattcc gcccctccta tgaataaaaa tgcttctata ctgaaaaata 1886281 aactgatttc tcgtctatta tacagaaatg tttgacaaaa gcggttcatt tgagcagttt 1886341 atatgacggg aaagaaatga cttgatataa tcaatctcta aaaaccttac gggaggcgaa 1886401 agaaatggcc agaaaattat ttacacctat tacaattaaa gatatgacgt taaaaaaccg 1886461 cattgtcatg tcgccaatgt gcatgtattc ttctcatgaa aaggacggaa aattaacacc 1886521 gttccacatg gcacattaca tatcgcgcgc aatcggccag gtcggactga ttattgtaga 1886581 ggcgtcagcg gttaaccctc aaggacgaat cactgaccaa gacttaggca tttggagcga 1886641 cgagcatatt gaaggctttg caaaactgac tgagcaggtc aaagaacaag gttcaaaaat 1886701 cggcattcag cttgcccatg ccggacgtaa agctgagctt gaaggagata tcttcgctcc 1886761 atcggcgatt gcgtttgacg aacaatcagc aacacctgta gaaatgtcag cagaaaaagt 1886821 aaaagaaacg gtccaggagt tcaagcaagc ggctgcccgc gcaaaagaag ccggctttga 1886881 tgtgattgaa attcatgcgg cgcacggata tttaattcat gaatttttgt ctccgctttc 1886941 caaccatcga acagatgaat atggcggctc acctgaaaac cgctatcgtt tcttgagaga 1887001 gatcattgat gaagtcaaac aagtatggga cggtccttta tttgtccgtg tatctgcttc 1887061 tgactacact gataaaggct tagacattgc cgatcacatc ggttttgcaa aatggatgaa 1887121 ggagcagggt gttgacttaa ttgactgcag ctcaggcgcc cttgttcacg cagacattaa 1887181 cgtattccct ggctatcagg tcagcttcgc tgagaaaatc cgtgaacagg cggacatggc 1887241 tactggtgcc gtcggcatga ttacagacgg ttcaatggct gaagaaattc tgcaaaacgg 1887301 acgtgccgac ctcatcttta tcggcagaga gcttttgcgg gatccatttt ttgcaagaac 1887361 tgctgcgaaa cagctcaata cagagattcc ggcccctgtt caatacgaaa gaggctggta 1887421 atgcccataa gagatatcct gtagaggata tctctttttt tatttttaga gaaacgatcg 1887481 gctaaggttc tccgtctccc tagtagaacc aattagagga gatgactcca atgaaatcag 1887541 cttggatgga aaagacatat acaattgacg gatgtgcgtt tcatacacag caccggaaag 1887601 gatcaagcgg tgtaacgatt gtctttgagg ccggctatgg tacttcttct gagacgtgga 1887661 aaccattaat ggcggacatt gatgatgaat ttggcatttt cacatatgat cgggcaggca 1887721 taggaaaaag cgggcaaagc agagctaaac gaacagctga tcaacaagtg aaagaattgg 1887781 agagtttgct taaagcagct gatgtaaaac ctccttattt ggctgtttca cactcatacg 1887841 gagctgtcat caccggttta tgggcctgca aaaacaagca tgatattatc ggcatggtcc 1887901 ttcttgaccc agctttaggc gattgcgcca gctttacctt tatacccgaa gaaatgcaca 1887961 aatcacatac gagaaagatg atgcttgagg gcacacatgc agagttttca aaaagtctgc 1888021 aggagctcaa aaagcggcaa gtccacttag gaaacatgcc tcttcttgtg ttgtcatcag 1888081 gagaacggac tgagaaattc gctgctgaac aggagtggca aaacttgcac agcagcatat 1888141 tgtctctatc taaccaaagc ggctggattc aagctaaaaa cagctcccac aacatccatc 1888201 atgatgaacc tcatatcgtt cacttggcta tttatgacgt atggtgcgca gcgtgccagc 1888261 aggccgctcc tctttaccag gcagtcaatt aacgtaaaaa aagaccgggc cgtaagggat 1888321 tcccggtctt ttatattatt ttgtttcacg gtgaagggta tatttcttta aacgcggtga 1888381 atattttttc agctccaaac ggtctggatt ggtgcgttta ttttttgttg tgatgtaatt 1888441 tcggtctccc gtttcagtgc aaagctaaag taacatttac tctcataatt aacatctcct 1888501 tataaaacgt aatgattacg ttttattata caacgtcatc acaaattgtc aaataagagc 1888561 tccgccttca gcctcgcggg acgtttacct ctaagaaatc atatgccgcc acgctattgg 1888621 ggaaaacgtc aaccgcttct ttttgaagct ccaaagaagc atctccctga tatcttgcgc 1888681 tgatatgggt taaaatgagc tgcttcgctc ttgcttcttt cgctgttaca gccgcttgtt 1888741 ccgttgtact gtgataataa tcataagcaa gtttacggtc ttccttagca aaggttgctt 1888801 catgaacaag cacatcacaa tccctcgcaa gctcttttag tttgtcactt actctcgtat 1888861 caccggagaa cacaacagat cttccctttt taggaggctc cagaaaatca ttcccattga 1888921 tgattcgtcc gtcttcaagc gttaccgttt cgcctttttt gattttctga tatacaggtc 1888981 cgggcgggat gttcatttct tttaatacgt cagccttcaa ggaacccggt acgtcttttt 1889041 cctgcacacg gtacccgaag gcttccactc catgaataac agataccgct gtgacaataa 1889101 actgatcgtc ctcaaacacg attccttctt caatttcctg gatcgcaagc ggatatgtca 1889161 aatgggtttt cgtgacggca aggcttgttt caataaacgc cttgatccct ttaggtccgt 1889221 acactgtcag ctcgtcctct ccgccttgaa aggaacggct ccccagaagc cccggaagtc 1889281 cgtatacatg atcgccgtgc atgtgtgtaa taaagatttt ctctatttta cgaggtttaa 1889341 tcgttgtatg taaaatttga tgctgtgtgg cttccccgca gtcaaaaagc cataccgaac 1889401 gcctttcttc aagcaatttt aatgccaccg acgttacatt tctcgccttg gcggggatgc 1889461 cggctcccgt ccctaaaaaa agtaattcca cgtttccttc ctcctactag aaccagatac 1889521 ctacaagaat acaggatcaa gcggaaaatg tgaatcttgc ctctgaaaag aacaatcctt 1889581 tcgtgctaga aacatttttt cagcattctg cttaaaaaag ggcttaaatg tttgctttcg 1889641 ttgaatttta gatttaaaat gaaggaaata tacggggtgt actaaaataa agcttcgaat 1889701 aaagtgaggt acttttagtg aaaacaaacc aacaaccaaa agcagtaatt gtcatattcg 1889761 gtgcaactgg agatttagca aaacgaaaat tgtatccgtc tattcaccgt ttatatcaaa 1889821 acggacaaat cggagaagag tttgcagtgg taggagttgg aagaagacct tggtctaatg 1889881 aggatcttcg ccaaactgtt aaaacatcca tttcctcatc tgcagataag catatagatg 1889941 atttcacgtc tcatttttac tatcacccgt ttgacgtgac aaaccctggt tcttatcaag 1890001 agctaaacgt attgcttaac cagctggaag atacatatca aattcctaac aacagaatgt 1890061 tctacttggc aatggctcct gaattcttcg gaacgattgc aaaaacatta aaatcagagg 1890121 gtgtaacagc tacaaccggc tggtcccgcc ttgtcatcga aaaaccgttc ggccatgatc 1890181 tgccaagcgc acaggcattg aataaagaaa tccgcgaagc atttacggaa gatcaaattt 1890241 acagaatcga ccattatcta ggcaaacaaa tggttcagaa cattgaagtg attcgatttg 1890301 ccaatgcgat tttcgaaccg ctttggacaa accgctacat ttcaaacatt caaatcacat 1890361 ctagcgaatc actaggcgtt gaagaccgcg caagatatta cgaaaaatca ggcgcccttc 1890421 gcgacatggt gcaaaaccat attatgcaga tggttgccct tcttgcaatg gagccgccta 1890481 tcaaattgaa cacagaagaa atccgcagcg agaaagtgaa ggtgctgaga gcactgcgtc 1890541 ctattgcaaa agacgaagtg gatgaatact ttgtgcgcgg acaatatcat gctggtgaaa 1890601 ttgacggtgt accggttcct gcttatacag atgaagataa tgtcgctcct gactccaata 1890661 cagaaacctt tgttgccggc aagctcttga tcgacaactt cagatgggct ggtgttccat 1890721 tctacatcag aaccggaaaa cgaatgaaag aaaagtccac aaaaattgtc gttcaattta 1890781 aggacattcc gatgaacctg tactacggta atgaaaacaa catgaatccg aacttgcttg 1890841 tcattcatat tcagcctgac gaaggcatta cgctttactt aaatgctaaa aagcttggcg 1890901 gagcagcaca cgcacagcca atcaaactcg attattgcag caattgcaat gacgagttga 1890961 acacccctga agcatatgaa aaactaattc acgactgtct tcttggcgat gcaacaaact 1891021 ttgcacactg ggatgaagtt gccctttctt ggagctttgt cgactctatt tctgaaacat 1891081 gggcagcaaa caaaacctta tctcctaact acgaatcagg ctcaatggga ccgaaagaat 1891141 ctgatgatct tttggtgaaa gacggcttac actggtggaa catataataa gaagaaaaaa 1891201 gccgaaaatg tttacaagca ttttcggctt ttttacgctg aacaaaggta taacaatctc 1891261 cttaataaca aaacccccaa agcttaagag cttcgggggt ttctattgat tacttcatcc 1891321 attcagtatg gaagatgcct tctttgtcag tacgctcata agtatgagcg ccaaagtagt 1891381 cgcgctgtgc ttggattaag tttgcaggca gtacggctgt gcggtagctg tcatagtagg 1891441 ctaatgcgct tgagaatgat ggcaccggca caccttgggc aactgcaagt gaaatcactt 1891501 ggcgaagcgc tccttgatag ctttctacaa tattcttgaa atagctgtca agaagcaggt 1891561 tgtcaagctc aggctcgcga tcgtaagctt ctttgatctt ctgaaggaat gccgcgcgaa 1891621 tgatgcaacc accgcggaag atcatagcga tttcaccata tttcagatcc cagttgtatt 1891681 cttcagaagc agctttcatt tgggcaaatc cttgcgcgta tgaacagatt ttactcatga 1891741 acaacgcttt tctgaccgct tcaatcagct cttctttatt ttctgtaaca ggcttcactt 1891801 ctggtcctga aagaagtccg ctcgctttta cacgctcttc cttcatagct gagataaagc 1891861 gtgcgaatac agattcagta ataatcggaa gcggaacgcc taagtcaagt gcgctttggc 1891921 ttgtccattt tcctgttcct ttttggcctg ctttatcaag aatcacatca acaagcggtt 1891981 tgcctgtttc ttcgtctttt tttgtgaaga tgtcagccgt aatctcaatc aggtagctat 1892041 caagctcacc tttattccat tcagcgaaaa cttcatgaag ctcatcagca gaaaggccca 1892101 gcacctgttt cagaatgaaa tatgattcag agatcagctg catatctccg tattcaattc 1892161 cgttgtgcac catttttacg taatggccgg cgccgtccgg accgatatat gtcgtacaag 1892221 gttctccgtc aacttttgca gaaatggctt caagaatcgg ttttacaagc tcatgtgctt 1892281 ctttttgtcc gccaggcatg atagaaggtc ctttaagcgc tccttcttct ccgccggaaa 1892341 cgcctgttcc gataaaatga atgccgcttt cagcgagttc tttgttacgg cgctgtgtat 1892401 ctttatagta tgtattaccg ccgtcaatta aaatatcatc cttctctaga tgaggaagaa 1892461 gagattgaat tgtcgcatct gttgcagttc ccgctttaac cattaataag attttgcgcg 1892521 gtgtttccaa ggattggaca aattcttcaa tgctgtaagt gccaacaaca ttttttcctt 1892581 ttgcctcctg taaaaactcc tcagttttac tgcttgatct gttgtaaaca gaaacagaaa 1892641 atccccggct ttcgatattt aaagccagat ttttacccat gaccgcaagt ccgataacgc 1892701 cgatttgttg ttttgacata ttctaacgtc ccttctgcaa acgtttaatc attttaaaat 1892761 ttaaattaaa ataaaatgat atttataata aagaaattac catacattca cccttttttt 1892821 caagcgattc agcttttctt ttcatcttga aaaaaatctt tattaaagct tgttcccttt 1892881 gttttgctct cctctttttt taacgttgcc ccttttctga tcagtttggt accgtacttt 1892941 ttattcagct tttccatcat ctgctgaatg ggctcatcct tcgcatcttc attaaagctg 1893001 aacaaatcga gctgtttata ggcctgctct ttttctacta aatccgttcc ggtaatgcca 1893061 agcagcctga caggattttt attccaatgt ttaaaaaaga ggtgctccgc ttctttcaaa 1893121 atgtcatttt tttgatcaat cgggtttctc agcgtagtgc ttcttgtgat ggttctccaa 1893181 tccgcatatc taatcataat aaaaagcttc gaagccatga cttccttgcg ctgtaaacgg 1893241 tcactcacag aagcggcaag ctttctaaaa acgcctaaca gctcttcttc atcactggaa 1893301 tcatgggaaa gtgtcgatga gttgccgacg cttttaaatt cgtaaatgcg ctccgggtca 1893361 accggcgcat ggtgaatgcc atttgcttta tttttaaggc gcggaccgtt gatgccaagc 1893421 aggcgcttca gcgagtgttc atcagctgca gctagctctc cgattgtatg gatgccgagt 1893481 cccttcagtt tttccgctgt ctttttgccg actccgtgca tctctccaac aggaagcggc 1893541 cacaggatat cgggcacttg cctctttctt aagatcgtaa ttccaagcgg ttttttcata 1893601 tcagacgcca tcttagcgag aaatttattc ggtgcaatcc ctatgcttga cgggagcagc 1893661 agctcttttt gcagcctgct ttggatttct tttgccgtct ctagagcgcg gctgctgtat 1893721 ggtgtatcgg tcatgtccat atagccttcg tcgatggaga caggctccac taggtcagta 1893781 tattcacgaa gaatggtaaa catcgctcgt gaagagtttc tatagcggtc aaagttcggc 1893841 ggaagaacga tgagctcagg acaatggcgc ttcgcttgcc aaaccggcat cgttgttttg 1893901 acgccgcgcg ctcttgcttc gtagctgcat gttaccacaa tgccctttcg ctcctttacg 1893961 tttccggcaa ctgcgaccgg ctttccccgg agagccggat catatgccat ttcaaccgac 1894021 gcataaaagc tattcatatc aatatggaaa ataattcggc tctttcccgg cataaacaaa 1894081 tctccttttc ggtcattaga caacagcttg tacatatagt aaaatgaagc tattgaatgg 1894141 atgtgatgac aatgtttgtg gaatcgataa atgacgtttt attcttagtc gattttttca 1894201 caattattct tcctgctcta acggcaatcg ggattgcatt cctcttacgg gagtgccgtg 1894261 cgggcgagca atggaaatca aaacgaacag atgaacatca gacggtcttt cacattaacc 1894321 gaacagactt tcttattatt atatatcatc gcattacaac ttggatacgt aaagtcttcc 1894381 gcatgaattc gcctgtgaac gatgaggaag acgccggttc tcttctttta taaaccgcat 1894441 ttataaaaag gaggagaaca aaattgttaa aaacatatca aaaacttttg gctatgggta 1894501 tctttttgat cgtattatgc tcgggcaatg ctgcatttgc agcgactaat caggtgggag 1894561 gcctcagcaa cgtaggtttt ttccacgatt atttaatcga accgttttcc gctctgctta 1894621 agggtgttgc cgggctgttt cacggagaat acggactctc tattatcctc gtaaccatta 1894681 ttgtgcgtat agttgtattg cctttgtttg tcaatcagtt caaaaaacag cgcatcttcc 1894741 aagagaaaat ggccgttatt aaacctcagg ttgacagtat ccaggttaag ttgaaaaaga 1894801 cgaaggaccc ggaaaagcaa aaagagctgc aaatggaaat gatgaagctg tatcaggagc 1894861 ataatatcaa cccgcttgcg atgggctgtc ttccaatgct gattcagtct ccgattatga 1894921 ttgggcttta ttacgcgatt cgctcaacac ctgaaattgc gtcacactcg tttctatggt 1894981 tcagtttagg gcaatctgat attctcatgt cccttagtgc agggattatg tattttgtcc 1895041 aagcctatat cgctcaaaaa ctgagcgcga aatattccgc tgtcccgcaa aaccctgcag 1895101 cgcagcaatc cgcaaaattg atggtgttca tcttccctgt gatgatgacg attttctcgc 1895161 ttaatgtgcc ggcagccctt ccgctgtact ggtttacaag cggactgttt ttgacagtgc 1895221 aaaacatcgt ccttcagatg acgcatcata aaagtaaaaa aacagccgct cttactgagt 1895281 cggtgaaata aaaaagcaac cccgtgcaaa aagccggggt tgttttttgt tacttgcaaa 1895341 gtaccgcgcc aaacagtctt gtttatcatg gctgaagcag aaatggccat cctaaaaaat 1895401 agccgtatcg tttaaaaaga aggaaatcgg gaataccttt actcacctcc aaccgaaagg 1895461 agcctatacg ttgacggaac gctttcagca aaaaaatatt tctgtacctg atggaatctg 1895521 gatcatgaga caaacctgga atgatgtctt atttgctcac tggcctgttg atgtttctat 1895581 ccttcgcgct ttggtaccgt ccgttttaga attagataca tataacgggc aagcttggat 1895641 cagcatgctt ccctttatgc tcacgaacct gagggcgcgt tatctccctg tcattcccgg 1895701 tgcgcgtgca tttcctgagc ttaacctccg cacctatgtc acgtataaag gcaagcccgg 1895761 catttatttt tttagcttag atgccgatca tcgtctggcg gtccttggcg ctcgcacatt 1895821 ctttcatctg ccttattttt acgcggatat gaagtccgaa aaaaacggtg atgccattga 1895881 ctatgtcagc aagcggaaaa atgacaaaga agcagcattc cacgccgcat accggccaat 1895941 ttcagcgcct tttacagcag aaaaggattc gctcgattac tggctgacag aacgatacag 1896001 gctctacacc acttatcgca ataagctcta ttacgaagac atccatcatc atccgtggct 1896061 gctgcaaaac gccgaagcag aaatttcagt caatacggtg actgatgctc acggtattac 1896121 attgccggag tcagacccct tgcttcatta tgctaaaaaa caggatgtgt tattttggcc 1896181 gcttaggaaa tggagctaaa aaaacccgat gcgggaaatc gcactcgggt tttctttttt 1896241 tattttgccg cctcttcaat aatggcaaca accatttctg ccgttttaac gagctcttcg 1896301 atcggcattt tttcattttt tgtatggatt tgctcataac cgacagcaag attgaccgtc 1896361 gggatgccat gaccagcgat tacgttcgcg tcgcttccgc cgccgctcgt ttgcagctcg 1896421 cttggacgtc cgattttagc agccgctttt ttcgcgattt caacaacttg gtcgccgtct 1896481 tgatatttaa agcccggata cataacctca atttcgactt ctgcgcgtcc gcccatatca 1896541 gcagctgcct cttcaaaagc agctttcatt ttttgaacct gagcttccat tttctcagga 1896601 actaaagagc gcgcttcagc aagaatatga acttcgtcgc acacaatgtt tgtttgtgtg 1896661 ccgccttcaa accggccgat attagctgtt gtttcttcat cgatacggcc caatggcatt 1896721 tttgagatgg ctttgctagc gattgtaatc gctgaaatgc ctttttcagg ttcaaccccg 1896781 gcgtgagcgg ttttcccgaa aattgccgct cttaccttcg cctgtgtcgg cgcggccaca 1896841 atgatatttc cgacttttcc gtctgaatca agagcatagc cgtaggatgc agtgatcata 1896901 gaacggtcaa gcgccttcgc tccgatcaga cccgattctt cccctactgt gatgatgaat 1896961 tcaatcgtgc cgtgttcaat attttcttct ttcagcacct taatcgcctc aaacattgca 1897021 gccaatcccg ctttatcatc agcacctaaa atcgtcgtgc cgtcagtttt gacgtaaccg 1897081 ttctctacaa ctggttttac gccgtttccg ggtacaactg tgtccatatg agatgtaaaa 1897141 tagatcgtat ctgtttgttt tgtccctttt agcgtgcaaa tcaggttacc ggctccgtgg 1897201 cccgtgatat ccattgtatc gtcttcttta acgtccacac ctaaatcaga aaattttcgt 1897261 ttcagcactt tgcagatttc agcttcgtgc tttgtttctg agtcaatttg gacaagctct 1897321 aaaaattctt ccagcaggcg tttttcattc accatttgta agtccctcca tattaaagcg 1897381 gtatgttacc gtgctttttt ttcggtctct cttctgtctt atgtgtaagc atatgaaaag 1897441 cttgaatcag tcttcccctt gattcttccg gcaaaatgat gtcatcgacc attccacaag 1897501 cggccgcttt gtatgggccg gcgttttgct ttttgtattc agcagttttt tcgcgtttcg 1897561 tcttttgcgg gtcagctgaa gctttgattt ccttttcata caaaatcgat gccgcacctt 1897621 ctggacccat cactgcgatt tcagcattcg gccatgcaaa cacaaggtcc gctccgatcg 1897681 ctttgctgtt catggccaca taggcgccgc cgtacgcttt tctaatgatg agtgtgactt 1897741 ttgggacagt cgcttcagca taagcaaaca ataattttgc tccatgcctg atgattccgt 1897801 tgtgctcttg ctgaataccc ggcagaaacc ccgggacatc ttcgacagtc aacagcggga 1897861 tatcaaatgc gtcacaaaaa cggatgaacc ttgctgcttt atcagcagcg tcaatcgtca 1897921 ggcttcccgc cagatgcttc ggctggctcg ccacgatgcc gattgctttt tcacccagcc 1897981 ttgcaaaccc aatgacaatg ttcttcgcaa aaaatggctg aatctcaaaa aaagactgcg 1898041 ggtcagccag ctccctaatc accttccgaa catcataagg ctttgtcgta tcagcaggga 1898101 caagacggtt taataacggt ctggacgcct ctttctctgg cttcggctct gttgtccggc 1898161 cattcagcgg caaataagac agtagttttc tcacccctgt cagaacctcc ttctccgtat 1898221 gcccggaaaa gtgggcgttt ccgctgacgg cattatgtat ccccgctccg cctaagctct 1898281 ccgcatcaac ctgttcccct gtcacttttt caatcacctt cgggccggta ataaacatcc 1898341 ggccagtctg ttcagccata aatataaaat ctgtgagtgc cggagaatat acagcgcctc 1898401 cagcgcacgg ccctaaaata accgatattt gcggaatgac tccggaatat aagacgtttc 1898461 ggtaaaatat gtgaccgtat ccatctaatg ataacacacc ctcttgaatt ctcgcaccac 1898521 ctgagtcatt cagcccgata atcggcgcct tattttttgc tgccagatcc atcaaagcgc 1898581 agattttcct ggcatgggtt tcgccaagcg cccctccgta cactgtgaag tcttgcgcaa 1898641 atacataaac tgagcgaccg tcaattgtgc cgtaccctgt cacgacccca tcccctaaca 1898701 tgcgctgttc tcttgttaac acttgacttt ccatgaaggg gtgtaattcg ataaagctgt 1898761 cctgatctag aagaaatatg atcctttccc gagcagtgag cttgcccttt tgccgctgct 1898821 gagccagctt ttcccgtcct ccgccttctt ctgcctgctt gcgtttcgtg taaaaatgat 1898881 ccatgtgctc attcatgctc attgtgttgg tctcctttcg gttcacaaag ctctacaaga 1898941 acaccgtttg tttcccgagg ggaaataaac gcgatctttt tcccgttcgc tccctgtctt 1899001 ggaaacctgt caatcaattg aacatgctga tcagacaatg cttgaagctg ttcagatagg 1899061 cagttgcaca aaaacgcaat atgatgcagt ccctgccctt tcttctccaa aaataaatgg 1899121 acggggctgt cagctgtcaa cggctctatc agctcaagtt tgacgctacc agcttgaaaa 1899181 aaagcaacat tcaccttttg ctcttcaacc gtttcttgat gaagaaatgc aagccccaat 1899241 acattttcat aaaagcttct tgcatctttt atcgaaaaaa cggctatccc gatatggtca 1899301 agcctgttca ttttcatccc tgctttcgct aatagatatc gcttgtccgc ccattcaaaa 1899361 cacgctaaaa tatagacaga ttgtttaagg agtgaaaatc atgtctcaaa aactgatgaa 1899421 aagcgttttg atcgtgattt tgggagtttt tattctttca actgtactct caggaatcgt 1899481 catgtttcta taacgataaa aaagcaggcg ccttattcaa tgggaatatc ctgctttttt 1899541 atcagagctt tatgctcgat ggcaatctcc tcaaaagagc ggttgtcgtc cgtgatcagc 1899601 actctcgttc ctactggtat cgtttgaaac aaatgaacaa cctcatcgtt atgcatacgt 1899661 atacagccgt tagacacaaa ttttcctact gattcctctc ggtttgtccc atgaattcca 1899721 taaatccgcc cgtccgttcc tttcgcgtca aatccgatcc atcttgcccc aagcgggtta 1899781 tcaggagatc ccccttcaat atttttcttt ctgtagtaag gattttccgc ttttaccgtt 1899841 accgaaaact ctccttcagg cgtcaaatca tctgtttttc cagtcgccac actatacacg 1899901 ccttctactt tgttgtcgag gataacagca agttcatttg ttcgcttgtt gacaataaca 1899961 tacggatcac ccggcagcgg attttcgccg agcggccaaa tcggtgaaat catcatgaaa 1900021 atcgaacata agaaaaaacg cataagctcc tcctttttca ttaggttgac caatgaagga 1900081 agagctcatg cgaatcatcc gagtgatttt tgcgctttta ttcctttaaa ataactttta 1900141 atcactaaat attgttccat ttcgccgaga agatggaaga gagcggccct cgcttcaaat 1900201 tcctctctag tcgcaggaag cggcatctcc tcaaattctt ttctcatgtc agcaagtctt 1900261 ttcagaaatt tgtatgctgt attcccaggg tgtatcgcct cccgcaaatc atgaataaat 1900321 tcagcgatca tttttccctg atctaccgtg atggagatcg atgtcacttt agggagaagg 1900381 cgttcgataa tttcaaattg cttttctctc attttaaaat aatgataatg cagattttca 1900441 taacgcaaaa tgtggttttg cacatctcga tatgccaggt ttttagcctc cgtaatgagc 1900501 tggtgcgttt ccggaatttc ttttcctgac caatcttgct caccagttaa caaataccgt 1900561 tcgatttctg caaaaatgac agcaaagtta tcctctatct ttttgcggta ggcaatcagt 1900621 ttccggtcaa gactaggcat atacaagttc atcaatagag cgacgccgat gccaaccgta 1900681 atcagctgaa cttcattcca gatgaaagta ggcgtaatgc cgccggacat gtataaatga 1900741 aggataataa cagaactggt gacgataccc tcgttaattt ttaacagaac cgttatcgga 1900801 atgaatatca aaagaagcgc tccgatcaca aacgggtggt agccaataag ctcgaaaaag 1900861 agataagaaa aagcaattgc cagacagcat gccgaaaagc gggcccatga ggcctgaagc 1900921 gaccgttttt gtgtgatttg tatgcacaaa atggtgatga ttcctgctga tgcgaagttt 1900981 tgcaaatgca ataactggct tatataaata gccaaagctg ttccaagcgc ggtctttatt 1901041 gtgcggtaac caattttaaa catgtcggac tccatttcta tttgtttctt caataaaaaa 1901101 gaagaggcgg ccagccttct tcttttttat attctataat attttctcta aaaagtcctg 1901161 cgctcttttg gattttggcg acataaaaaa ttccttcgga ttgccgtctt cgacaatcat 1901221 tccttggtcc ataaacagca cacggtctgc cacttctttt gcgaagccca tttcatgtgt 1901281 gacaatcacc atggtcatgc cggtttcgac cagctctttc atcacctgta gcacttcttt 1901341 gaccatctct ggatcaaggg cggaggtcgg ctcgtcaaac agcatgatgt ccggattcat 1901401 cgcaagagcc ctggcaatcg cgacacgctg tttttgtccg ccagacaaac ggtttggata 1901461 gtcatttcgc ttttcaaaca aaccgacttt gcggagcagg tcctcagctt tctcctgtgc 1901521 agcctgtttt gattcttttt ttacattgac aggcgcgtac atgatgtttt cgagaaccgt 1901581 tttgtgcgga aagagatgaa aatgctgaaa aaccatcccg atgttttccc ggacctttaa 1901641 tgtgttggtt ttcggcttcg taatctctgt gtcttttatt gtaatggttc cgccgttagg 1901701 cttttccaac aggtttaaac agcgtaagaa cgttgatttg cctgagcctg aaggaccgat 1901761 cacggcaaca acctcaccct cagcgattgt tgttgaaatg ttttttaata cttcgtgttt 1901821 cccaaatgat tttgacagct tttcaacctt aatcattgga tttcagcttc ctttctacag 1901881 ccttgccgat aaacgttaaa atcaggacaa gcacataata aatcaatccc gcgataatga 1901941 gcggctcaag gtaattgtaa gtggcggcgc cagcttgata tgcgcgtctc atgacatcac 1902001 caagcccgat gacggtgacg atcgccgatt cttttgttaa cgtaattaat tcattcacaa 1902061 ttgcaggtga tatatttttg aaggcctgcg gcagcagcag atccttcatc atttttccat 1902121 acgggacacc gagtgcaaca gcagcttctt tttgcccttt atcaatggca ttgattccgg 1902181 ctctgataat ttccgataca taagcggcgg aattcaaaga caatgcgaca accgcagccc 1902241 aaaactggtc aatttgaaat ccgagcagct gaggaaggcc aaaatagaca atcataagct 1902301 gcagcactaa aggcgtgcct cggaacactg atgtataaaa atcagcgatc cagataaacg 1902361 ggcggaatgt gctgatcttg cataagctta gcacaatacc gagtataagt ccgataatag 1902421 cagatacaac aacaattttt aatgtaattg ccaagccttc taatataaaa ggaatttggg 1902481 ggatcgttgc tgaaaaatcc aaattcatag cctttgtctc cttttcttac aggaaaaaag 1902541 tttcctattc aataaaaagg ctcaacgaaa aagttgagcc gctttttttt acttctcgcc 1902601 agtgaaccat tttttcttca atttctcaag ctctccgtta tcttccattt ccttgagcgc 1902661 tttattgaat ttgtctgtca gttcactgtc ctttctgaaa gcaattgctg aaccggcttc 1902721 ttccgctttc gcatcaggaa tcacaaagcc ttgcaggtca tcatttgatt tgaaataccc 1902781 ttctgcaaca atgtcttcaa taatcgcggc atcgaagcgg tcagatttga tttcctgcac 1902841 caaatcagaa attctgttgc ggtcttctgt tttaaaacca tattccggag aaagctcttt 1902901 ccccttctct tcctgaatag agccaagctg aacgccaact gtttttcctt tcaggtcttt 1902961 caaagattga atgccgctgt cttttttgct gacaatcata tggttcgctg tgtaatacac 1903021 atcggaaaaa tcaacttgtt ttttacgctc aggcgttggt gtcattcctg acagaacgag 1903081 atccacctgt tttgatttaa gcgctgtaat taagctgttg aagtccatat cctgcacttc 1903141 aatttcatag cctgccttct ttgccagagc ttttgccagc tctacatcaa agccgacaat 1903201 attatctcct tctttatatt caaacggttt gtaatccgcc gaagtaccca taattaattt 1903261 tttctttccg ctttctgaac ctgaattgct tgagccgcac gcagttaatg caaaggtgat 1903321 gcaagcagcc acaagtaata agagccattt tttcatgatc catttccccc gtattcatta 1903381 cttttggtgt atttgaatat ttattcgtta atttgtattt taaacagttt ctcattttta 1903441 tgcaatacta tttttaaaaa ttatctttag gcttatcttt ccagtgatct cttctgatat 1903501 tactagataa aaattaaatc gctgtacaat ccgattgaat aatcccttaa tatttattca 1903561 tatatccttg gaaatttatg cacaaaaaaa cccgggctgc tttgagcatc cgggttgttc 1903621 gtcttatact tcttcacaat attcttcaaa ggcttcctgc agctttgcca ctacagccat 1903681 cggctcatgg ccttcaattt catgacgctc taccattttc atgatctttc cgtctttcaa 1903741 aatcgcaaag gacggagaag atggtggata accttcaaaa tagtcacgcg cacgcgctgt 1903801 cgcttcttta tcctgtccgg caaaaacggt gacgagctga tcaggtcttt tatcatagtg 1903861 aacggaatgg taggctgccg gtcttgcaat tcctccggcg catccgcaaa cagagtttac 1903921 catgacgagc gtcgttcctt ttttcgtaag tgcctcatcc acctcttcgg ctgttttaag 1903981 ctcggtgtat ccggcagctg ttatttcttg tctcgcttgg cggacaatat cattcataaa 1904041 taaattaaag tccatgttca atgaagacct ctcctttttc atcatctgtt cttatgatag 1904101 caaggaaacg tccatatcgg caaatgactt tgcttcgccg tgcacttttt ttgctcttcg 1904161 tttactgctt acagaaaaag gggattatat aaccagaagt aaaataaagg agcagttgta 1904221 tatgagccac cggaaagcgt tactgattca taacggaaat gccggcaaca aaaatataga 1904281 aaaagcactt ggtgctgtgg tgccggtttt atctcaccat ttagatgagg tgattattaa 1904341 acagacaaag aaaaaggatg atgcgtatca tttttgccga tccattgatg attctgtcga 1904401 caccgtcttc attctcggcg gcgacggcac gatccatcaa tgcataaatg ctatcagcgc 1904461 tctagaaaga aaacccgctg tcggaatttt gcccggcggc acgtgcaacg acttttcaag 1904521 agtgcttggc atccctcaaa atcttgcaaa ggccgcggaa gcacttatgg cgggaaaaaa 1904581 aaccagcgta gacgtatgtc agatgaatga ccgttatttt ttgaatttct gggggatcgg 1904641 cttaattgca gaaacgtcga atcaaatcaa cgaaacggaa aaagcattat tgggaaaaat 1904701 cagctatttt acaagtgcct tgcgaaccgt ctcatctgct gcatcgtttc cgatgacatt 1904761 aaaaattgat ggagaagaaa ttaaagaaga agccgttatg ctgcttgtga tgaatggcca 1904821 atacattgga acgaatcgaa ttcctctgcc cgatgccagt attgaagacg gcttacttga 1904881 tgttctcata tgccgcaata ccaacctcac cgcgctgcgg gagctgatga gcatggaaca 1904941 aggctcaatt gatcgtttta ctggagagtt gtcctatgtc caggcttccc gtatcgagat 1905001 tgaaacagac actgccaaaa aggcggatat ggatggagaa gtttatacac atacacccgc 1905061 agtcattcag gtcctgccac agcatatcga catgcttgtt cccgcaaatg aataactgtc 1905121 ataaggcttt agaaagattt tgcaaatccg ttgactctcc cctaggagga ggtcttacag 1905181 tataagggat acacacttga aaaaggggaa gtcatatgga gaagaaaaat attaccttaa 1905241 ctatattatt aaccaattta tttattgctt ttttggggat cgggcttgtg attccagtaa 1905301 cgccgaccat tatgaatgaa ttgcatttat cggggaccgc ggtcggctat atggttgcct 1905361 gcttcgctat tacacagctc attgtctcac caatagccgg acgatgggtt gatcgcttcg 1905421 ggcgcaagat catgatcgta atcggcctgt tgttctttag tgtgtcggag tttttgttcg 1905481 gcattggaaa aacagttgag atgttattta tctcccgtat gctgggcggt atcagcgcag 1905541 ccttcattat gcccggggtc acggctttta ttgcagatat cacgaccatt aaaacacggc 1905601 caaaagcgct cggttatatg tcagccgcta tttcaacagg atttattatc ggccccggca 1905661 tcgggggatt tttagcagaa gtccattccc ggctgccttt tttctttgcg gcagcttttg 1905721 cactgttagc agccatttta tcaatcctca cgctgcgcga gccggaacga aaccctgaaa 1905781 atcaggaaat aaaaggacag aagacaggct ttaaacgaat ttttgccccc atgtatttca 1905841 tagcttttct cattatctta atttcgtctt ttggtttagc atcatttgaa tctttatttg 1905901 cattattcgt ggatcataaa ttcggattta cggccagcga cattgccatt atgattacag 1905961 gaggagcgat tgttggcgcc attacgcaag tcgtcttatt cgaccgcttc acaagatggt 1906021 ttggcgaaat tcatttaatt cggtacagct taattctctc gacgagtctg gtattcttgc 1906081 tgacaacggt acattcatat gttgcgattc tgctggtgac agtcaccgta tttgtcggat 1906141 ttgatctcat gcggcctgcg gtaacgactt acctgtcaaa gattgcggga aatgaacagg 1906201 ggtttgccgg cggtatgaat tcaatgttta caagtatcgg caatgtattc gggcctatta 1906261 tcggcggaat gctgttcgat atagatgtaa actatccttt ctactttgca acggtcacct 1906321 tagccatagg gattgcactg accattgctt ggaaagcgcc tgcacatctt aaagccagca 1906381 cgtgataaga agcgcattct ttgtgtactg caaagaatgc gcttcttctt tatactgatg 1906441 atagaaggag tgatggcatg aaggaatcgt attactcaat tggggaagta tcaaaactgg 1906501 caaacgtgtc gataaaagcg ctccgttatt acgataaaat tgatttattt aaaccagcct 1906561 acgtcgaccc ggataccagc taccgctatt atacagattc tcagctcatt catctggatt 1906621 tgatcaaatc attgaaatat atcggcacac ctttagaaga gatgaaaaaa gcacaggact 1906681 tagagatgga agaactgttt gctttttata cagagcagga gaggcaaatc agggagaaat 1906741 tagacttttt atcagccctg gagcaaacca tttcattggt gaaaaagcgg atgaaacggc 1906801 agatggaata tcccgcgctc ggtgaggtgt ttgttttaga tgaagaagaa atacggatca 1906861 ttcagacaga ggcagaagga atcgggcctg aaaacgtgct caacgcctcc tacagcaaat 1906921 taaaaaaatt tatcgagtca gcagatggat ttacgaacaa tagctacggc gctactttct 1906981 cttttcagcc ctacaccagc attgatgaaa tgacttaccg tcatattttc acacctgtat 1907041 tgacgaataa acagatttca tcaattacgc cggatatgga aatcacaacg atccctaaag 1907101 ggaggtatgc gtgtatcgcg tataattttt cgcctgaaca ttattttctc aacttacaga 1907161 agcttatcaa atatatcgcg gaccgccaat taacagttgt cagtgatgta tacgagttaa 1907221 tcataccgat tcattactcc ccgaaaaaac aagaagaata tcgagtcgaa atgaaaatac 1907281 ggatcgctga ataataaagc atagaaaaag agcatttttt gaaacaaaac ttcaaaaaat 1907341 gctctttttg cttatttagt aaacagatgt cttctcgtca atcgattcta aaatttgttt 1907401 cactcgtccg aggaatcgtc cgcacacgag accgtcaagc actctgtgat ctaatgacag 1907461 gcacagatta accatgtctc tgacagcaat catgccattg tccatgacaa ccgggcgttt 1907521 gacgatggat tctacttgaa gaatcgcagc ctgagggtag ttgataatgc ccatcgactg 1907581 aacagacccg aacgaacctg tgttgttgac ggtaaacgtg cctccctgca tgtcatctgc 1907641 agtgagtttt ccgtctctta cttttttagc taggccggta atgtctttcg caatgccttt 1907701 aattgttttt tcatcagcgt ttttaatcac cggaacaaat aaagaatcct ctgtggcaac 1907761 tgcaattgaa atattgatat cctttttctg aataattttg tcccccgccc acatgctatt 1907821 catttgcggg aattctttta acgcctgagc gaccgctttt acaaaaaagg cgaagaacgt 1907881 taaattaaag ccttctgtct tcttaaaaga atcttttata ctgttgcgat atgcaaccat 1907941 atttgtgacg tcgacttcca tcatcgtcca agcatgcgga atttctgttt tgcttcgctt 1908001 catattggaa gcaattgctt ttcttacacc tgtgacaggg atttctttat caccggctgc 1908061 agacgcagga tatgacgtct cttcttttgg ctcaggtttt gatgcagact tcggtgcagg 1908121 agctgctgtt ttcagctcct caggattctg ttcttgcacg ccgcctgttt caattaagcg 1908181 ctgaatatct tttcgtgtga tgcgcccgcc ggcaccagtt cctgtcactt gatcgaggtc 1908241 aatgccgtgc tctccggcca aacggagaac agctggcgag tagcgctttt tattgggctg 1908301 atcggctgct ccagcacttt ttgcaacagg gttctcagcg gcttctgatg ctgctggctg 1908361 ttcttgtttt tgttcagccg gattcgcgcc ttctgtttca attttgcaaa tcatttctcc 1908421 gacttgcagg gtttggcctt cttctcccac aagctctgtt atcgtaccag taaaagaaga 1908481 cggaacctct gcatttacct tatctgtcat gacttccgcg atcggatcgt atttgttcac 1908541 tttatcaccg ggggcgacaa gccatttgct gatcgtcccc tctgttacgc tttctccaag 1908601 ctgcggcatc gtcatttgtt caattgccat gattgtatcc tcccttacgt ctttaaaact 1908661 ccgctaattc tctcatcgcc gcttccactt tatcagggtt gaccataaag tatttttcca 1908721 ttgtcggcgc ataaggcata gccggaatat caggacctgc aagccgtttg atcggcgcgt 1908781 ctaagtcgaa cagacaatgc tcggatataa ttgcggctac ttcgctcatg atgctgcctt 1908841 cttttgtatc ttctgtgacc aaaagaacct ttccagtttt ggacgcagct tcgatgatgg 1908901 cttctttatc aagcgggtaa actgttctta aatccaccac atgcgctgaa atgccatctt 1908961 tttcgagacg ttctgcagct tgtaaggcga agtggacaca caggccgtat gtgatcactg 1909021 tgatgtcgtc gccttccctt tttacgtccg ccttgccgat tggcaggaca taatcatcag 1909081 ccggaacctc gccctttatc agacggtatg cccgcttgtg ctcaaaaaac agcacggggt 1909141 cttcgtcacg aactgcggct tttaagagcc ctttcgcgtc atatggtgtt gatggcatga 1909201 caattttcag tccgggctgg ttggcgaaaa ttgcttcgac tgattgagaa tgatacaggg 1909261 ctccgtgcac gcctccgccg tatggcgctc tgacgacaat cggacagctc cagtcattgt 1909321 tgctgcggta gcggatttta gccgcttcag aaataatttg gttgactgcc ggcataatga 1909381 aatcagcaaa ctgcatttca gcaatcggtc tcattccgta cattgccgct ccgataccga 1909441 ctcctgcgat tgcagattca gcaagcggcg tatccataac gcgctcttcc ccaaattgtt 1909501 catagagtcc cgctgtcgct ttaaacacac cgccttttct tcctacatct tccccaagga 1909561 cgaaaacgcg agaatctcgt tccatttctt ctttcatcgc caaattgatt gcatcaatat 1909621 atgacattac tgacatttgt tcttcctccc tacttcgcat aaacataatc aagcgctgac 1909681 tcaggagctg catatggggc gttctccgct tcatccgtcg cttcatttac gattgccata 1909741 atttcatcca gcatggtttg ttctatctca tcggacagca ggcctgtttc ctttaagtaa 1909801 gcttgataag taagcagggg atcacttttt ttcgcttcct ctacttcttc acggcctctg 1909861 tagctgctgt catcgtcatc actggaatgt ggtgtaaggc ggtaagaaat cgtttcaatt 1909921 aatgtcgggc cttctcctct gcgtgccctt tcgcgtgctt ctttaaccgc ttgataaact 1909981 tccagcggat catttccatt cacagttacg ccaggcatcc catagcctat ggcacggtcg 1910041 gaaatgttct cacatgcgac ttgcttatcg taaggcactg agattgcgta tttgttgttt 1910101 tcacacatga aaataaccgg cagcttatgg acagcggcaa agtttgcccc ttcatggaaa 1910161 tcgccttggt ttgaagaccc ttccccgaat gtaacaaagg ctgcgatatc ctttttctcc 1910221 atacgtcccg caagcgcaat accgactgcg tgcggcactt gcgttgtaac cggagatgat 1910281 cccgtcacaa tgcggttttt cttttgtccg aaatgtcccg gcatctggcg gcctcctgag 1910341 ttcggatctg ctgcttttgc aaacccggac atcattaagt cctttgctgt catgccaaac 1910401 gcgagcacga cacccatgtc tctgtagtac ggcaatacat aatccatttc acggtcaagt 1910461 gcgaaagccg ctcctacctg tgctgcttcc tgtccttgac aagagattac aaatggaatt 1910521 ttgccagaac ggtttaacag ccacattctt tcatcgattt ttcttgctaa cagcatggtt 1910581 ctatacatat caacggcttc ctgatcagtc agccctagtg cttgatgtcg gtttgtactc 1910641 attcaagccc ctcctttatg cttttaaaaa tgaatggctt tgccatctgc ggcaagcgca 1910701 gcttctccaa ttgcttcaga aagcgttgga tgcgggtgaa tcgtttgccc gacctcccac 1910761 ggtgttgcgt ccagcacttt ggcaagaccc gcttcagaaa tcatgtcggt gacatgcggg 1910821 ccaatcatat gaacgccgag aatatcatct gtatctcggt cagccacgat tttgacaaaa 1910881 ccgtcgcttt caccgtatac aagcgctttt ccaatcgcca taaatgggaa cttgccgatt 1910941 ttgacattat gcccgttcgc ctttgcttcg tcttcggtta agccgacact ggcagcttca 1911001 gggcttgagt aaatgcactt cggcacaagc gtcggatcaa gcggatgcgg attgagacct 1911061 gcaaaatgct caacagcaat aattccctca tgtgaagcaa cgtgagctaa ctgcaggcca 1911121 ccgattacgt ctccgattgc ataaatatga gattccttcg tttggcagct ttcattgact 1911181 gaaatcatgc cattttcagt aacaatatcg gtgttctcta ggccgatgcc ttcgatattt 1911241 gcctgtctgc cgatggaaac aagcattttc tcagcagaat aggtaacggt ttctccgtct 1911301 ttttccgctt gtatgctgat atcgtctgat gtttttgtca ttgtgtcagg cagcactttt 1911361 gcccctgtta tgaactggat gccttttttc ttaagaagac tttccatttc ttttgaaatc 1911421 tctagatctt cagtcggcaa tatgcgatcc gcgtattcaa taaccgttac cttaacgcca 1911481 aaatcatgaa gcatagacgc ccattcgata ccgataaccc ctccgccgac aatgatgatt 1911541 gactgtggca gctcctccat ttggagcgcc tcatctgaag tcagtacaga cttaccgtcc 1911601 acttcaagac ccggaagcat tctcggtctt gatcctgttg caatgatcac ttgtttcggg 1911661 atcagcatgt cattttcttc gccatttccc cgctcaacag aaattgttcc cggcagcgga 1911721 gagaagattg acggtccaag gatacgtcca tatccggtgt acacgtcaat ttttcctttt 1911781 ttcattaaat gatttacacc cgctgcaagc ttatcaacaa cggcttgctt acgctgctgc 1911841 actttttcaa agttgaggga cacgccagcc gtttccactc cgaattgatc ggcttcacga 1911901 gctgtccggt atacctctgc gcttctaagc agcgctttac tcgggataca gcctttatgc 1911961 agacatgttc ccccgagttt ttccttttcc acaacggctg tttttaagcc gagctgagcg 1912021 gctctgatgg ccgcaacata accgccggta ccgccgccca gaatgactac gtcatactca 1912081 gttgccatgg tgactcactc ctgtctgtct attcaatacg atattgtttg gattgctctt 1912141 cgccctgcaa tactcttagc gccccttggg caagagactg cagttcattt tcacccggat 1912201 aaactaaaac gtctgaaatc caatctatgt atgatctgat agcagaaaca aagctttttc 1912261 cgtacgcaag gcctcccgtc agcacaatcg cttcaacttc gccttttaac gccgcgctgg 1912321 ctgccccgat ttcctttgct acctgatatg ccatggcatc ataaatgaag cgggcttttt 1912381 catcgccccc ttgaatcatc tgttccactt ttactgcatc atttgtaccg agatagccta 1912441 aaagtccgcc ggtgccaaca agctttttca tgatttcttc ttttgtatat tcccctgaaa 1912501 aacatagatc aacaagatct cccgcaggca ctgttcctgc tcgttcagga ctgaatggtc 1912561 cctcgccgtg caggccgtta ttgacatcca ccactcgccc gcggtcatgg acgccaattg 1912621 taatacctcc gcccatatgg gtaataatca ttttcatgtt ctcatatcgt ttgccaaggg 1912681 aggctgccgc tttacgagcg acagcttttt ggtttaacgc atggaaaatg cttttccttt 1912741 caatttcagg catgcctgaa actttcgcaa gcactgacat ttcgtctacg acaacagggt 1912801 cgacgatata cgaagggata ttcaggccgt cagcgatttc ccgcgcgata atgccgccga 1912861 gattagaagc atgctgaccg gcgtagccgc ttttcaaatc ctcaatcatc tcatcattca 1912921 ctacgtaggt cccgccttca attggccgga gaaggccgcc tcttgcgcag actgcatcaa 1912981 actttgaaat attgattccc tgttcatgaa gcgtttcgag aatatggttt ttacgaaatt 1913041 catactgatc aataattcgg tcaaatcgct gcagctcttc tatgttgtgt ctcaatgttt 1913101 tttcaaaaat gcttctttcg ttatgaaaaa caccgatttt cgttgaagtt gagcctggat 1913161 taattgtgag aatgcgtttt tcgtcatgta gcactttcat aacctccaga tcaatttctt 1913221 aacgtctgct taatacactg tggccgtttt gcaaaaactg gcttcttgag cggcgcatgc 1913281 gttcaatccg ttcctctgct aagcggtcag ccgctaaata tgcaggaatg ccgtcacgct 1913341 gagaaatctc aagtacacgc tcgatattgc cgtaaatgcc ttcaactttt ttcaatgcac 1913401 gttctgcatt atagccgtaa agctcatctg ccacgttgat gacaccgccc gcgttaatca 1913461 cgtaatccgg tgcataaacg atgcccattt cgtgaatttg atcaccatgg cgtgtctctt 1913521 ttaattggtt gttagccgca cctgcgatca ctttcgcctt cagctgttta atggtgtcgt 1913581 cgttaatagt cgcaccaagg gcacacggcg cataaatatc gcagtcttgt gaataaatgt 1913641 catcaggatc taccgcacgg gcgccaaaat cttcaactgc acgctgtaca gattgtttgt 1913701 tgatatccgt aacgattaag tttgctcctt cttcatgcag gtggcggcaa aggttatagg 1913761 ctacgttccc aacaccctgt acagcaatgg tttttccttc aagagagtcg gttccgaaag 1913821 cagctttagc tgctgccttc attcctctgt acaccccgta cgctgtgact ggggacggat 1913881 ttccagaaga gccgaaagca ggagaaatcc ctgtgacata gtctgtctca tcatgaatga 1913941 tatccatatc ctcgaccgtt gtgcccacat cttcagccgt gatgtatctg ccattcagtc 1914001 cttgaatata gcggccaaac gcgcggaaca tttcctcatt tttgtctttg cgcggatcgc 1914061 cgataatgac tgtttttccg ccgccaaggt ttaagcctgc cgccgcgttc ttataggtca 1914121 tgcctcttgc caatctgagc gcatcttcaa ttgccgcttc ttcattttca tatgtccaca 1914181 ttctcgttcc gccaagcgcc ggaccaagcg ttgtatcatg aatggcgata atcgctttta 1914241 atccagattg ttcatcctgg cagaatacca attgttcgta atcgtatttc tccatatatt 1914301 taaaaagttc catgttcgtt cctcctaatg tgtgtattct tcagatgcgc atattgccag 1914361 cgcaatggaa tacagtttat tttcagcaga gtccgctctg cttgttaaag caatcggtgc 1914421 ttttgctcct gtaatgacag ccgccacgct ggccttggca aaataaatca gtgatttata 1914481 taaaatattg ccggcctcaa ttgttgggac gagaaggata tctgcgttgc ccgctacgtc 1914541 tcccgaaatt tttttctggg ccgcggcaat ttgtgaaact gcgttatcca aagcaagcgg 1914601 tccatcaaca atgcagcctt tgatctggcc ccttttgtac atttgagcta gagcagctgc 1914661 attcacggtc gcttccattt tagggttcac cgtttcgacc gctgcaaggg cagctgcttt 1914721 tggcatattg ttccccactg catgggccac atgaacggca ttttgcaaaa tctgccggag 1914781 ctcttccagc gaaggagcaa tattcattgc cgaatctgtc acaaacatca gccggtcaaa 1914841 atccggtata tcgaagacag ccacgtgaga aaggacactt gctgaccgaa gcccctcctg 1914901 tctgttcaat accgctttaa gcaaaacaga agtcggcaca ttgcctttca ttaaaacgtc 1914961 cgctgtttta tgatgcacag cacgaaccgc taatttcgcc gattcctcag gagtattggc 1915021 atggacgatt tccacttgat gcccttgcat ggatgatgtc agctcgttca gttttttgct 1915081 gtcgcccgtt aacaagaaac gggcggatag gtgctcggct gccagcttta cagcccggat 1915141 cacttcctca tcctcagcat gagcaaccgc aatggtctta tttttgtgta tcgacgcttt 1915201 gccgattaaa tctttcagct tcatctgtta ccacctttct tgtttcgact ccgcctttta 1915261 ttatgcaagt tccatgccag ctcttaaggg tgctgtcata ccaggtatac cgaaacattc 1915321 gtgcagatgt ttgcgtttat tctgcaaatt attgcatgcc ttcatttgca aggccatatt 1915381 tatccatttt gtaatataaa ttccgaatgc tgacaccgag agcttttgct gtttttgtcc 1915441 ggttaaaatg atgcttttca agcgtttgct ggatcaaatg cgcttcaaat ttttctactg 1915501 cgacagacag cttttcgcct tcaatatccg gaaaatcaaa acctgttccc tgatctgtgt 1915561 cattttcttt ttgctcaagt tcgaatacag gcaagtgatc tttttcaatc cattccatat 1915621 gcggattcag aaaaatcatg gctcgtccaa ggacattttc aagctcccgg acattcccag 1915681 gccaatggta ggcagataag gcgcgcaagg cttgctgtga gagccctttt acattcctgc 1915741 cgtaatcccg gttgatcttt tggataagtc tgacgctcaa tgcttcaatg tcctccaacc 1915801 gctgccgcaa aggcgggatg gagatcggat agcgattgat ccggtaatac aggtcttccc 1915861 ggaatgttcc gtccgccatc gccttttcaa tatttacatt tgtcgccgcg atcactctga 1915921 cgttgacagg gatcgctttc gtgccgccca ctctgacgat ttccttttct tgaaggacgc 1915981 gtagcaattt ggcctgcata ttttgtgtca gctcaccgat ttcatctaag aaaatactgc 1916041 cgttatttgc ttcctcaaat aaaccctttt taccgccgcg cttcgctcct gaaaacgcac 1916101 catcctcata gccgaacaat tctgattcga gcaggttttc agaaagggct gcacaattca 1916161 cgcgaataaa tttattgtat ttccggtcac tttcgttatg gatggcatgg gcgaacagtt 1916221 cttttcctgt tcctgattcc ccgcgcagca agatggttgc cggtgttttc gcaccgagct 1916281 tcgcctgctc aagcgcaacc agcatttgct cgcttttgcc gataatgtcg tcaaacgtgt 1916341 atttcgcttc aagcgtgcga ataatttgtc tggcgcgatt aagctccgct gtcagcattt 1916401 taatttcgga aacatcgtga atcacgccga cgctgccttt caaaatcccg tccacaatca 1916461 ccggtgctac attaacgatc acttcttttt cattcgggcc gaccttcatt ctgacaccgc 1916521 ggacaggacg tcttgtttca agcaccttta aatgcatgct ttcgccttcg gaaatatcag 1916581 tgtttgcagg cttgccgatg acttcttttt cagaaagccc cgtcattttc gtatacgctt 1916641 tattgattag caggccgatg ccgttttcat caacgacaga aatcgcctca tcggaggatt 1916701 gaataattgc ctccagcatc gtacggacct gctttaagtt ggtcacttcc tctgccagct 1916761 cgaccgcatc agtgatatct ttaaacacac aaagagcccc gagcagacgt ccgccttcat 1916821 caataatcgg cagtcttgtg gtcacaattt gcaaatgatc gcctaacagc tgcttctggt 1916881 tgtattcagg cactcttgtt tttaaaatcc gcggcatctt agtgctcgga atcacttctt 1916941 ttattgggcg cccaatgact tcctcacgtt tttttccgac cattttttcg gccatatggt 1917001 taaagagaat gatttcttca ttgatatcaa taaaaatcat tccatcatgg gtggaattaa 1917061 aaattctgtc atatttatag gtttgctctt ttagcatttg aatcaggtgc tgcttttctt 1917121 ccatcagctg aaaaacgatg tatgccattt ttcccggcat gacaatggta tcttcatgct 1917181 ttctttgaag gagctcgtca aacacggctt gatcgccggt agtatgaatg acgatatccg 1917241 gtttttgttg tatgtaaggt ttccaatcag atgatacggc aatcccatac tgttctgctt 1917301 ctttcaatcc cggcgcctcg gggtctttgt caactacggc aatgatatct atgatggctg 1917361 ttttaatcag aatatgtaat aacgccgttc cccttttgcc ggcacctact atcagtacct 1917421 tttgcatccc gatacccctt tgtatgaaaa aatttgcaca cctatttatt ccgttgcaat 1917481 aatttgcaca accctatgtt accacgtttt cttctcttga caaaatattt tttccgctgg 1917541 acaataaagg aaatgaaaag ataaaggggt tttctgaaga tgagccgact tcttgcgctt 1917601 ttaatattag tcatccccgg ggctatttct gctttaggca ttaaactgat gagagataca 1917661 cttttcggcc atacaatcaa gccattttca gctctttggc tccaagggtt gtcaggattc 1917721 atcttttttg cgatcggcct ctatgtgctg gccgggttca ttttatacag agacagaaaa 1917781 cgcaatcaag tcagcccgcg attcagaaaa cgatagctga aaaaaagccg gagaatgctc 1917841 cggctttttt tgttgcatta ttcgtcaggc aaaacggtct tggcaatcgt tttgtctaac 1917901 gcttcatagt cataataaga aatcgtatcg tacagttctt ttcgtgtctg catatcatga 1917961 agtccttctt tttgtgagcc gtgctccttc atcaaaccaa acatccgctc acaagctttt 1918021 gccgccgctc gaagcgaggt gacaggatat atcaccatgt gaaaccccat atcttcgaat 1918081 tcatcggcac gataatatgg cgttttccca aattcagtca tattcgcaag gagcggaacg 1918141 gggatacgct cagcaaactg gcggaattca ttctccgcct gtagcgcttc cgggaaaatt 1918201 gcgtccgctc ccgcctcaat gtaagcctct gaacgtttta ttgcggcatc aagcccttcc 1918261 tgcgccctgg catcagtacg ggcaacaaca ataagggagg gtgccgcttg tttaatggct 1918321 tttatttttt gcgccatttc ctttatcgga actagctgtt tgccatttaa atgtccgcat 1918381 ttttttggga gctgctggtc ttccatttga acggctgcta ccctggcttc aagcatctcc 1918441 cgggctgttc gggcggcatt taagacaccg ccaaatcccg tatcgatatc cacaagcaaa 1918501 ggcagatcag ctgcacgcac aagatctttg gcccgttcag ctatctctgc cgatgtgatg 1918561 atccctaaat caggcagccc cctgctggct gtataggcag caccggacaa ataaatagca 1918621 gaaaaaccgg cttctttcgc aagcaaagcg gccatcccgt catgggcgcc gggaatttga 1918681 agaatgtccg gtgctgacat cagcttgcgg aaacgcccgg caagctcctc ttgtgacgat 1918741 tgcttattga cgatccacga catgaaacaa aatccccctt ttacatgcag aacatgtcta 1918801 cgaattcatt tacgcgcatc gtttgtaatg tctcatagct ggtacagcgc tcataaatgt 1918861 gtttgtgctg tttatcagga aaatgggttt tgagattgtc agaaaacttt tccagcagtt 1918921 tcggcactgc ttcctctctt cgaaaacgat ggccgagggg aaactcacat tccaccattt 1918981 ccgtgctcgt tccatcttta aaatgaacct gaacggcatt tgagatggag cgtttatcag 1919041 gcttcaaata atcctcggta tatgttttat tttcagtcac ttccatttta tcacgaagtt 1919101 tatctattct cggatcattc gctgtttcag cttcataatg ctgtgcggtg atatcaccaa 1919161 aaagcaaacc gattgctgta atgtattgga ggcagtgatc acggtctgcc ggattgtgga 1919221 gcgggccttt tttatcaatg attcggatag ctgattcatg cgttctgatg acaactcggt 1919281 caatctcgtc aatccggttc tttacctgcg ggtgaagaat gacggcggac tccgccgctg 1919341 tctgggcgtg aaattccgca ggataagaca ctttaaataa cacattttcc atgacataag 1919401 cgtcgagcgg acgggcaagc ttgatctctt tcttattgaa taaaacgtct tggaaccccc 1919461 aacccggtgc actcaaggct gtcggataac ccatttcccc ttttaacgac atcagcgcca 1919521 aatgaacacc tctgctcgtt gcatctcctg ccgcccatga tttacgcgag cctgtattcg 1919581 gtgaatggcg gtatgtcctc aatgctgcat tgtcaatcca tgcattcgaa agcgcatttt 1919641 tgatttcttc tcttccgccg cccaaaagct ttgctgcaac agcagttgtc gcaactttga 1919701 caaacagcac atggtcaagg ccaactcgat ttaagctgtt ttctaacgcc agcacacctt 1919761 ggatctcgtg tgctttgatc atcatctcaa gtacgtcgcg taccgttaac ggctcttttc 1919821 cttcagacag cctcactctt gatacataat cagcagcggc aaggattcct cccaagttat 1919881 cggatggatg cccccactcc gccgccagcc acgtatcgtt gtaatcgagc cagcgaatca 1919941 tgcagccaat attaaacgct gccctcacag gatcgagaac atatgacgtt cccggcactt 1920001 tgcttccatt cggcacagtc gttcctggaa caatcgggcc aagcagcttt gtgcattccg 1920061 gataccgtag cgccaagatt ccgcagccca gggtatccag caatacatgc cccgctgttg 1920121 tatacgcttc ggcactagta atctctttct caagcacata gtctgtgatt tcttcgataa 1920181 cacgatccgt tttcggcatt ctaccagctc ctttcatgat tttgtttgat atcgcgggcc 1920241 catgtaactg acacggggac ggaagagccg attattggca tgctgttcga tcacatgggc 1920301 gcataaaccg gacgttctcg cgctgaaaaa gatcggcgta tataaaggaa tcggtatgcc 1920361 gagcatccaa tacactgggg cagcatagta atccaaattc gggtaaagcc ctttttcctt 1920421 ctccatcagc cgctcacccg cttcgcacat ctcatataaa cgatggtcac cggctttatc 1920481 gcataattgc tgcagcgcct ctttcatcat gagtgctctc gggtccattt ttttcatata 1920541 cacccggtgg ccgaagccca tgattttttc ttttcttttc agttttgttt gcaaaagctg 1920601 ctcaaaatca gatgtcgttt ttgcctccaa aagcaaatac atcacagctt cgtttgctcc 1920661 tccgtgaaga ttccctttca gggaagcgac agccccagtc aaagccccat aaagatctga 1920721 atgtgtagat gcaatgaccc tggccgcaaa ggttgaattc ggcatctcat gctcactgta 1920781 caggacgagc gaccggtcaa aaatctgttc ttccaatgaa gacggcaatt tccctgtcat 1920841 catgtagaga aaattcgcac tgtaggatag ggtttgaagc ggaagaatcg gttctttctt 1920901 attaatgatc ctgtagctgg cagcagtgag ggcaggcatt ttcccaagaa gctgataggc 1920961 gcgttctttg tttgcggaag gagaccgatc atcaatttgc cgatcatagc cagcaagtgc 1921021 cgacaggccg gtacgcagac catccattgg atgagtgtcc tcagggagca gctcaagcag 1921081 acggagatga tcagcaggca ggcttgaggc actgtttatt ttacgttcca gcgtttccat 1921141 ttcactttct tctggcagcc tgccctccag caataaatgg acaagctcca gatagctttt 1921201 tgtttcagaa agttctatta aatcatagcc tcttatcaaa atctggctgg actgcgtgtc 1921261 aagataagaa atatgagttt ctgccgcaat cacaccgtcc aaccctggag aataatgctg 1921321 tttctcctcc atatcctcaa cctccgtttt tgcgtttttt gtctatcagg ttccgccaag 1921381 caaatacttg gaaataatca gtctttgaat ctcgttcgtc ccttcataaa tttgcgtcac 1921441 ctttgcatcg cgaagcaggc gctcaactgg ataatccttc atatagccat atcccccata 1921501 aatttgaacg gcgtctaacg ccgcctttac ggctgcatcg gaagcaaatt gtttagccat 1921561 agacgcttct tttccacagt ttaggccgcg gttatgaagg tctgcagcgt ggtagacaag 1921621 atgtcttgcc gcctcagctc tagtcgccat atcagccagc ttaaatgata tgccttgatt 1921681 ggctgcaatc ggccttccaa attgcactcg ctgcttcgca taatcaacgg catgctcaag 1921741 agccgcctct gcaattccga gggcctgtgc cgcaatgccg atccggccga catttaaatt 1921801 cgccatggca atgtgaaagc catccccctc tttgccaagc aaattggctt caggcacttc 1921861 tgcattatca aaaatcagtt ccgtagtatt ggagccataa agccccagct ttctttcttt 1921921 ttttccaacg gtaaaaccgg gtgtgttttt ttcaacaata aaagccgaaa tcccgtgcct 1921981 gccttgatct ggagctgtta aagcaaatgt gatatagata tcagctgctc cgccattcgt 1922041 tatgaatatt ttcgatccgt ttaataggta tttgccgttc tttttgattg ctgttgtgcg 1922101 gaggctcccg gcatccgacc ccgagtgagg ctccgttagt gcaaatgcgc ccaaatggtc 1922161 tcctgacgcg agatttggta tatatttcat cttctgttct tcgttgccga aatacagaat 1922221 cggattcgtg ccgactgagg tatgaacgga gagaatcacg ccgacagccg cgctgattct 1922281 agaaatctca tgaattgcca aaatataaga aacaacgtcc gctccagcac cgccgtattg 1922341 ttccggcacc ggtattccca tcagtccgtg tttacccatt tttttgatca gctgaaaggg 1922401 aaattcgtcc gttttctcca tgatttccgc agcgggagca atttcttttc gtgcaaaatc 1922461 acgcaccatt tttcgcatca tgacttgctc ttgggttaca tgcaactcgg ccacccccgg 1922521 atggaataga cttcaggaag tcttctcctc atagtcataa aaaccgcgtc cgctcttttt 1922581 gccaagccag cctgctttga catacttgcg gagcagcggg caaggacggt atttggaatc 1922641 gccaaggcct gagtgaagga cttccataat tgataaacac gtatccagtc cgataaaatc 1922701 cgctaatgca agcggaccca tcggatgatt catgcccagc ttcatcactt catctattgc 1922761 ctccggcttc gccactccct catacacgca atagatggct tcattaatca ttggaagaag 1922821 cacacggttg gaaacaaacc caggaaaatc attgacttct accgctgttt tccccatctt 1922881 ttccgctaat gccataacat ctaaggccgt ttcttctgat gtagccaagc ctcgaatcac 1922941 ttctaccagc ttcattacag ggacgggatt cataaaatgc atgccaataa cccgttgagg 1923001 ccggtttgtt acagcagcga tttctgtaat aggcaaggaa gatgtattgc tggccaaaat 1923061 cgtatgaggc gggcaaatgc gatcaagtgt tttaaacatc tcagtttttg ccgccatgtt 1923121 ttctgcgata gcctcaatca caatgtccgc atgctctgcc tcctcaagtg tttgagaaat 1923181 cgaaatgcgg ttgattacgc tcttcacttc cgtctcggtc ctttttcctt tctcagcatc 1923241 acgggccagc tgtttcttca gccgtttcaa tcctgcctcc gcggcctctg gattcacatc 1923301 atacatccgc acataaaagc ccgcgtcggc ggctgtttga gcaattccgc tccccatctg 1923361 acctgcgcca gctaccatga tttgtttgat ttccattcaa atcccctttt tcatcatgtt 1923421 ttaatgaacc tgcactaaga cggcgtctcc ctgtgctgcc ccgctgcaaa tagcggcaac 1923481 gcccagaccc cctccccgtc gctttaattc ataaacaagc gtcatgagaa ttctcgcacc 1923541 gctcgcgccg atcgggtggc cgagcgcgat cgcaccgcca ttcacattta ctttttcaag 1923601 atcgaaacct acgatttttt cacatgtcaa aacaactgaa gcaaaagctt catttacttc 1923661 aaacaagtca atatcttgga cagttaaacc attctttttc aggagcttgt taatagcaaa 1923721 ccctggcgct gccgccagct cgtgcgctgg cattcccgta gttgaaaaac caagaattgt 1923781 agccagaggc cgtttgccaa gctcagcagc tttttcctca gacatcagca cgaacgcgcc 1923841 ggctccgtca ttgactccag gagcattgcc ggctgtgata gaaccgtcac ttgcataaat 1923901 cggagcaagt tttgcgagct gatccagact tgtgtcacgg cgaatcgctt catctttatc 1923961 aacaacgttt ggttttcctt ttcgaccgat ccagttgacg ggaacaattt catcctgaaa 1924021 cttcccttca tcggcggcct tagctgccct tgcatgactt ctcaacgccc attcgtcctg 1924081 ctctcttcgt gagattgcat attccttggc agctgtattt ccgtgaacag ccatgtgcac 1924141 ctcgtcaaat gcgcacgtta atccgtcata caccattaag tccctaagct cgccgtcccc 1924201 catccgtgct ccccagcgcc cggcgggaac ggcatacgga atattgctca tgctttccat 1924261 cccccccgca acaagtatgt ccgcatcctg cgcccgaatc atttgatcac ataaagtgac 1924321 agcgcgaagg ccggaagcac agactttatt cagtgtttct gacggcacac tccaaggcat 1924381 tcccgccaga cgggcagctt gacgggaagg tatctgccct gagccggcct ggacaaccat 1924441 gcccatgacg tttccttcta catcatctcc agagactcca gcctgttgca gcgcctcctt 1924501 catcacaatg cccccaagct cagcagcttt cacctctttc aaaactccgc cgaatttgcc 1924561 aaatggagtt cttgcagcac ttacaatgac tgttttcctc atggtttcac ctcattcaga 1924621 agatagacag cgcttacaat ttctagttgt cttctatgaa tgtatgcttt gaaacgggca 1924681 tgaatgaatg aaaaaagaag gctgcgtcaa acagcctcct tctaacaact attcattttt 1924741 cagcaatgcc gaagcctttt ctggaaagtc ggtaaacatg ccgtctgctc ccgcttcaat 1924801 gagacgcttc atatcttccg gacgattgac tgtatacggc cttaccttaa tcaaaccgtt 1924861 cctcattttc ttcagtactt catctgtgac ccctgggctg tttatcttcg ggtgatagcc 1924921 ggaagccgga atagacgcga tatatcgatc tgcctgataa agcacatctg aagttaatac 1924981 tgcccgttcg atatgcggtg caagccgggc gcacagcgcc aagctgtcat gattaaacgt 1925041 ggataggatg actctgtcct ctacattaaa tcgcttcact gcctccagca ctttttcttc 1925101 cattccctca tagcggatca cgctgttttt taattcaatg ttgatgagaa aatccttttt 1925161 taccgcccac gagagcacat cttctagcag cggcactttt atatcgctgt acgcttgatc 1925221 gtgaccagcg gccgcattcg cagtctttac ctcatcatag gctgtatcct tcacgaatcc 1925281 tttaagtgat gtcgtgcgat taagtctttc atcatgaatt acaacaatgc gtccgtcttt 1925341 cgtcagctgt acatcaagct ctatcccatc cgctccggct tcaattcctt tttcaaatgc 1925401 aagcattgta ttttcgggaa attgacctga tgccccccgg tgggcaaaaa tctttgtcat 1925461 cgtttcacct caaaccctaa agttttctcc attatactta ttttgtcggc tccactctag 1925521 gattaaggct gtatcaatct actgatcata ataagaatca atgccattga caatcgcatc 1925581 tgcggccttt tgctggtatt cttcacttcc cagcttgtcc gcgtcagagc tgttcgtgat 1925641 aaacccaagc tccgccaaca cacttggcat ttgtgaatat gtaatgacgt aaaagtctga 1925701 ttctttcacg cccctgtctc tcgtttgtaa ggaagaaacg agctgtgact gaatatcgga 1925761 tgccagacgc cggctgttct ccccttcata atcagattga aaatacgttt ctgttcctga 1925821 agctgaagca acccctgaat tcacatgaat gctgacaaaa aggtcagcct gattggcact 1925881 tgccttagcc actctttcct ccaaggtcag aaaatgatcg tcagaccggg atgcaacagg 1925941 attggctccc tcctctttta gtttgtctgt cacatgctct gagacagcca aattaatatc 1926001 cttttcaaag agcccgtttc cgaccgctcc actgtcttca ccgccgtgtc cggcatcaat 1926061 atacactgtt ttcccttcta tcggctctgc tgcctgtgca caaggcgcga gcgtcaaagc 1926121 caatccgcac agcgccaagc tcctccataa cattctcaac ttactccctc cggtcacgag 1926181 ttctttcgca gctgaatatc ttccagctgt aaagttccat tatccttctt tgtatatttc 1926241 accaggacat gtgtctgatc tggcagtgat tcacattcat cacgtttatc cttcggaact 1926301 tgtatcatgg tttcttctcc attaagagaa accgcaatcg tatgaggatc agccgagcca 1926361 atgtattttc cctcttcggt aaacctcggc actgagtcat ccgcacttgc aacactgcac 1926421 cccgaaagaa agagcgcagt aaacagcaaa agaaccgttt gtttcacatg accacctctt 1926481 cctgatgttt ggcttttatc tttgaccaga atggagaatt tgtaaagaca acgcgaatgc 1926541 aggcgagcaa gttccatgat tttcaaaagg gctatacgac ccgatcattt cctgttgtta 1926601 gaaagataac gagcagattt gtctatgagg atggctctaa ttgaggcgcc aattagaaaa 1926661 aattagcgga aagaagcaac tttttattca ttttaaaaaa tttgagaata gggtgagcaa 1926721 atcgtttgac gggtgggtca gccaagcgta accttttaaa ggatatttac tttattgaaa 1926781 gaagttaaag ccatgaaaaa attcgttctg ctgctggcgg cagctgtcat cacatgctcc 1926841 atcggccacc aaatcagtgg cggctacaaa ggccccgaaa aagagcggcc aaaacatcac 1926901 tctgcactca agatattcag tcggtaaagc agatcaattg cattaatttt tacatatagg 1926961 ctagaatatg tgcgaatcca aacgaaagaa gatgatcaaa tgaatcctaa gtataagcca 1927021 ctttttgaac catttacgtt taaaagcggc gttacaatca acaaccggat cgcagtagca 1927081 ccgatgactc attacgcttc taatgaagac ggtacaatat ctgaagcgga gctcgactac 1927141 atcatccccc gttcaaaaga gatgggaatg gtgattacag cctgcgcaaa tgttacaccg 1927201 gacggaaaag cattccccgg gcagccggcc atccatgacg attccaacat tccaggttta 1927261 aaaaagttag cacaagccat tcaggcacaa ggcgctaaag ctgttgtaca aattcatcac 1927321 ggcggtattg agtgcccgtc tgagctcgtt cctcaacagg atgttgtggg gccaagtgac 1927381 gtgtttgata acggcaaaca aattgctcgc gcattaacag aagaagaagt ggaaaacatt 1927441 gtgaaggcgt ttggagaagc gacaagacgc gccattgaag ccggctttga cggtgtcgaa 1927501 attcacggtg caaacggcta cttaattcag cagttttatt ctccgaaaac caaccagcgc 1927561 acggatcgct ggggaggaag cgatgaaaaa cgattagcct tcccgctcgc tattgtcgat 1927621 gaagtgaaaa aagccgcttc agaacatgcg aagggtgcat tcttagtcgg ctaccgcctg 1927681 tctccggaag aacctgagac accgggattg acaatgactg aaacttatac gcttgttgat 1927741 gctttagggg ataaagaatt ggattatctt catatctcac tgatggacgt gaactcaaaa 1927801 gcgcgccgcg gtgcagatcc gactcgcaca cgcatggact tattgaatga acgtgtcgga 1927861 aacaaagtgc cgctgatcgc cgtcggttcc atccattccg ctgatgacgc gcttgccgtc 1927921 atcgaaaacg gtattccact ggtcgctatg ggacgcgaaa ttctagttga ccctaactgg 1927981 acggtaaaag taaaagaagg ccgtgaaaag caaatcgaaa cagtgatcaa aggcacagat 1928041 aaagaaaaat atcatttgcc tgaaccgcta tggcaagcaa ttgtgaacac acaaggctgg 1928101 gtgccttata aagattaatg tgcaaagact gccgaaacga ttcggcagtc ttttttccct 1928161 ttatataaat agtttgtgta cacatctaaa cagcaaaaga aagagctccc caccaacttc 1928221 gaaaagaaaa tccaggaaaa acccctcacg ctttcttgct tttttctttt tcattcgtac 1928281 gtctcctttt tacatgaata cgccttactt acgattttgc aggagaaagg tttcatttta 1928341 taacggacac atctagggtc gatcatgctt cgtgatccta taagatgtat gaatggacca 1928401 agagtgcagg taataccgcc atttgctttc cttacttttc aaacctatcc tttactatat 1928461 gcggatactt aatattcttc tcccatacta caaatgtccc caaaacaaaa cgcctcctat 1928521 ttatcagcgc aaactaataa ataaaagacg tttgatttaa tgaccactta ataagctcat 1928581 gtttaagaag ccttatgctc taacctcagc ttatccgcaa ccattgcaat gaattcactg 1928641 ttggtaggtt tagcttttgt catgctgaca gtataaccaa acaacgagga aatggaatca 1928701 atgtttcctc tgctccatgc cacttcaatt gcatggcgga tcgctctttc tacacggctt 1928761 gcggttgtgt taaatttttt ggcgatgtcc ggatagagga cttttgtaat gctgccgagc 1928821 aattcgatgt cattgtatac cattgagatt gcttcgcgca gatagagata gcctttaata 1928881 tgggctggga cgccgatttc atggataatg cttgtgatgc tcgcgtcgag atttttcttc 1928941 tttggttcag gctggctgct gcgtataata ctgctttgcg atgatggcgc acgatgcgtc 1929001 acactgctgg catttccgct gacctggcgg atatggccga caaggttttc catatcaaac 1929061 ggtttgagaa taaagtagga cgcgcctaaa tcgacggcct ttttcgtgac atcttcctgc 1929121 ccaaaggctg tcagcataat gacattcggc tgttttttca gatctgattc cctcagcctc 1929181 tctaaaaccg caagtccgtc tagatgcggc ataataatat ctaatacgag cacatcggga 1929241 tctttttctt taaacagcga caggcattcc tgtccgttat aagcaacgcc gatcacttcc 1929301 atgtcttcct gtccttctat atattcactt aacaggctta ccagctctcg attatcatca 1929361 gcaacacaaa ctttaatttt ctccacgttt cttcctcccc aaatgtagtt aacaggattc 1929421 acccttgcta catgtttaca ttcgacaaaa ccgctatata ccctctaaaa aaatcataat 1929481 caccaatatt agtggcatat ctttgttatt ctatgttttt ctctgttttt cgactaaaaa 1929541 tgaaatttga caaacaagga aacgtgaatt tgtcgaaaaa tcttcttttg tatattttac 1929601 cgtatgtatt ctgagaagtg aagagggatc aggatatact gatgaacgaa tggatgtgca 1929661 cgaaaaaaat aagctgcgct tctcgcgcag cttacccagt tgttttgact tgatccgctt 1929721 gttttaaaag ttctttcgca tggcgtttcg ttaagtcggt tacttcgaca cctgcaatca 1929781 tgcgcccgat ttccgctacc ttttcctgct tagagagcgg cttgacacgt gtcgtcgttc 1929841 tgccgtcttt taactccttc gcaatataaa gatgcgtatc ggccatggca gccacctgag 1929901 gcaggtgtgt aatgcacagc acttgtgatc ctattgacac cttatggatc ttctcagcaa 1929961 ttgcctgtgc gaccctgccg cttacaccgg tatcaacctc gtcaaaaatg atcgatgtca 1930021 catcctgttg tgaggaaaaa atgcttttta tggcaagcat cacccgtgac agctctccac 1930081 ctgaagcgac tttcgaaagg gatttcagcg gctcgcctgt attggttgaa attaaaaact 1930141 tcaccaggtc aatcccttgt tcagtcagct gaacgggctg gccgtttaca agcggcgcct 1930201 cttcattgcg tgacgctgtt ctgaccttaa attccgtatc aaaagttgat ttttccatgt 1930261 acaggctttt taattcccga tgaatctcat cagccagctt tttcgcccat gtttttcgga 1930321 tttgtgacac atttgccgct tccactgcga catctttgcc gacggagtca agctcctttt 1930381 tcaagctttg aaggtggctg tccctgtttt caatttggtc aatctcttct tcaattttag 1930441 aagcatattc caaaatgtct tcaacagtgg caccgtattt tcgtttcagc tgtttgattt 1930501 cattaagtcg cgtctcaata tagttcaggc gttccggatc aaattcaagc tcatccagca 1930561 tatttctcat ctgaaatgtg gcatcctcaa gcaaatagta ggagttcgaa acactttcag 1930621 acattttttt cagcggttcg tttatatcag atatatcttc aagctgcgct gatgccattc 1930681 caacccagtc caatccgccc tgctcactgc gaagcgcgtt atatgcattt tgcagcgact 1930741 catatatctt ctcaaagttt gaaatttgct ggcgctcttc ttggagctgt tcatcttcgt 1930801 taagctcaag ctttgccgat tcgatttctt cgagctgaaa ttgaataaga tcaagacgat 1930861 gggccatttc ctgttcgctt tcagaaagct gcttaagctt tttgagcagc ttcacatacc 1930921 gctggtaccc ttcctgatac gttttgagcg cgctttccac ttcggccccg gcaaacttgt 1930981 ccaaaagctg gagatgattt tcgtcttcca ttaacagctg gttatcgtgc tgcccgtgaa 1931041 tatctaataa aagcctgccg atctctctta gtgaagcaat cgtgacaagc ttgccattga 1931101 cacggcaaac gcttttcccg ctcgtgctga tatcccttct catgacgatc atttcgtctg 1931161 aaacgtcgat tccctgctca gcgcatacgc ctaaaacagg atggccgctc tccaacagaa 1931221 acagcccttc aagttcggct tttgcttccc catatctaac aaattcagat gatccgcggc 1931281 ctccgactaa aagagaaatg gcatctatga tgatggattt gccggctccg gtttctcctg 1931341 ttaaaaccgt aagcccgcgt tcaaaagaaa ccgtcagttc ctcaataatg gcaaagtttt 1931401 taatcgatag ttcagctaac aaacagcatt acacctctta tctttgttag attttctgtt 1931461 acagcagttc aaggagcctg ttttttacgc cttctgtatc ttcaggagtc cggcaaataa 1931521 ttaaaatcgt atcatctccg caaatggtcc ccatcatttc atcccagtcc aaattgtcca 1931581 tcagcgcccc gattgcctgg gcattgcccg gcatcgtttt cagcacaatc atatggcttg 1931641 ctgagtctat tttcacaaat gcgtccatca atgcccgctt tagctttgac agcggattga 1931701 aacgctggtc cgccggaaga ctgtatttgt aagaaccatt atttgtaggc acttttacaa 1931761 ggtgaagttc tttaatatcc cgtgataccg tggcctgcgt tactttgtat ccatcctgct 1931821 ttagcatgtc gaccaattca tcctgcgttt cgatttcatt gcttgtaatg atctctctga 1931881 ttttaatatg cctctggcct ttgttcatgt aagcacctct atttccaagc ttatctgttc 1931941 ttttatgtta tatgattctc tgcacattgt acatgaatgc agaaaaaagg aataatagcg 1932001 ccctattatt ccggtacatc tgcttttttt tcttttaacg tcttatgtgc ttcttctaca 1932061 acgcgcatga tctcttcttc cggcagttcc tggccttcct gtccctctcc cggccaatgc 1932121 aaatgaagga gaaactcaat atttccgtct cctcccgtga ttggagaaaa tgacaagcct 1932181 ttacagatat agccttcagc ggcagaaaaa ctgatcattc gcttgagcac atcagcatgc 1932241 actttaggat ctctaacaat cccttttttg ccgacggatt cccgtcccgc ttcaaactga 1932301 ggcttaacta aagccatgca gtcgctgccc ggtacgagca aagtccttag gacaggcagg 1932361 atgagccgca gtgaaataaa ggacacatca attgtggcaa actccggcat gccctttgta 1932421 aagtctgccg gtgttgcata acgaaagttc gtccgttcca tcacgacgac ccgttcatcc 1932481 tgtctaagct tccatgcaag ctgattatag cctacatcca cagcgtatga ctgtttagct 1932541 ccattttgca aagcgcagtc cgtaaaaccg ccggtggagg agccaatatc aatcataatt 1932601 ttatctttga cagagacggg aaattccttc aacgcttttt cgagctttaa gccgcccctg 1932661 ctcacatacc tcagcgggtt tcctttgaca gttaacggaa ggtcgcggtc aattttttct 1932721 ccaggcttgt ccaagcggtt ttcgtttgaa tagacgatcc ccgccataat ggctcttttg 1932781 gctttttcac gcgtttccgc cagccctctt tccactaata atacatctaa tcgttctttc 1932841 tttgacgtca tgatccaatt cctttgtgtg tctttggtgg catcagtaat ctaatacgat 1932901 ttgccacctg ctgttttgtc agtccaattt cctcaagaag cgctgttaca cttccgtgtt 1932961 caataaaccg atcaggtata cccattctgt caatcggagt atgatattca ccttgatcat 1933021 gagcgaattc taaaatcgag cttccgaaac cgccttctaa gaccgcttct tcaattgtta 1933081 aaattggcaa gccttctttt aggatactct tcatcatctt ttcatcaatc ggcttaataa 1933141 aacgcgcatt cacaacgcgc acggaaaggc cttctttctg cagctcttcg gctgcttcaa 1933201 tcgccatttc gattgttgtg ccgaatgtta agatgacagc atcgttccct ggacgcagca 1933261 cctcccacgt accgatcgga atcgttttca actgttcatc catttttacg ccgagtccgt 1933321 ttccgcgcgg aaaacgcatt gctatcgggc cttcgtcata gctaagtgct gtatgaacca 1933381 tgtgctggcc ttcattttcg tctttcggca tcattaagac catgtttgga atgtggcgca 1933441 taaacgcaat atcaaacacg ccttgatgtg tctctccatc agcgccaacg agtccagcac 1933501 ggtcaattcc aataaacaca ttagcgtttt ggcggcagat gtcatgaaca acttggtcat 1933561 atgccctttg caggaaggtt gagtaaatcg ccaaaaacgg cttcataccc tgcattgcca 1933621 tagctgcagc cattgttgcg gcatgctgtt ctgcgattcc tacgtcgaac atccggtcag 1933681 ggaattcctt tgcgaagcct tcaagctttg aaccgacagg catagccggc gtaatggcta 1933741 caatgcgtcc gtcctcgcgc gccattcgct gcacagttcc gctgacaaga ccgctccacg 1933801 aaggagctgc ggctttcggc tttacaaagt caccggtatt aattttatat ggtccggtac 1933861 catgccatgt cccaatcgta tcggtctcag ccggtttgta ccccttccct tttttcgtaa 1933921 tgacgtgcag aagaacaggg cctttcgttt ttttggcgta ttgaagattc tcaatcagct 1933981 catgataaga atgtccgtcc actgggccca aatacgtaaa accgagctcc tcgaaaaaca 1934041 ttccggagac gagcatgtat ttcaggctgt ctttgacccg ttccgccgtg gcggcaagct 1934101 tgcccccaac tgccggaatc tttttaaata agtattcaag ctcatctttg acccactggt 1934161 atttccccgc agtgcggagc cgtccgagca tagagtgaat ggcaccgacg tttggcgcaa 1934221 tactcatttc attatcatta aggatgacaa tcatgtcttt tttctcgtcg ccgatgtggt 1934281 taagggcttc gagcgccata ccgccggtca gcgcgccgtc accaatgatc ggaataatat 1934341 attcatccgt tcctttaata tcacgggcag ctgccattcc catcgcgcct gacagagaag 1934401 tcgagctgtg cccggtttcc caaacatcgt gctcgctttc actccgcttt ggaaatccgc 1934461 aaagcccttt gtactggcga agcgtcgcaa attcttttcc gcgtcctgtc agcagcttat 1934521 ggacatacga ctgatggcct acatcccata aaaatttgtc tttcgggctg ttaaattcct 1934581 tatgcagggc aacagtaagc tctacgacac ctaagtttgg gccgatgtgg ccgccggaag 1934641 cggataaact tgtaattaaa aactgacgga tttcatcact taatttctct aattcatcaa 1934701 tggacatgtt ttttaaaaac gacgggtcct gtattgataa aagatccaaa gcggatcaac 1934761 tcactttcag catgaatttc tgcaatgata catgtctttt gcatgccgag ctgacaataa 1934821 tctcagacat aaaaaaagac aaacgcgctt ttccttttca tttttcatat aaactgctta 1934881 cattttacca tacctcgtgc agccgcttca aattaggatc gttttagtga tctcttgccg 1934941 caattaaatc acaaagctca tataaaaggt ctttttgaag agagagtccg ccgatcaatc 1935001 gcttcgcctc ttttatatga acatccaatt tatgtttggc cccttccaat gaaagaagcg 1935061 acgggtatgt cgatttgtca tttgtggtat ccgagccgac acgtttgccg attttctctt 1935121 cactgccttc taaatctaaa atatcgtctc tgatttgaaa tccgattcca atgtggctgc 1935181 tgaaggtacg cagtgtttca atgtcttcct caggcgcatc agccaaaata gcaccggcga 1935241 ttacacaaaa gccaaggagc ttggcagttt tccgttcatg aatggattcg agctcttcaa 1935301 gcgtgacttg tcggttttcc gcttccatat cagctacttg cccaccgacc atgccttcgg 1935361 tgcctgccgc tgaaatcagt tcattcacaa gccgcaggcg cttttctgct gacacctcgt 1935421 ctgacacgtg ggaggtaatc agcttaaagc tttctgtgag cagcccgtca cccgctaata 1935481 ctgccgtcgc ttcaccaaac actttatggt ttgtcggctt cccgcggcgc aaatcgtcat 1935541 catccatgca tggaagatca tcatgaatta acgaatacgt gtgaatcatt tcgacagcac 1935601 agcccaccgg aatgccgtct ttttcgcttt ttccatatgc atttaaaaca gccagtacaa 1935661 tcagaggccg caaccgcttt ccgccggcct gtagagaata tagcatagat ttctttaatg 1935721 agtccggcat atcaagcttt tctgtataga cagaaagctg attttcaatt gtttttttcc 1935781 ggtccgccag aaagctcgtt aatttatttg tcaccttcgt cttcctcctg aacactgaaa 1935841 ggtgccagtt cgccgtcttc ttttaaaatg aagtccattt gcttttcgac tttttgcagc 1935901 ttttcatggc acatttttga cagagccatg ccttcttgga aatagttaat ggcttgctct 1935961 agaggcacat ctccctcttc aagctttgat acaatgctct caagcccttt catcgcttct 1936021 tcaaatgtca tgttttcatt ttttttcacg tctgtcattt ttcttcccct ctcttttcta 1936081 atacttcaca ggtcagcacg ccatccttca gcttgatttc aagccggtcc tgctcttcta 1936141 tttgactgac acttttaatg agtttatctt ctttataagc caagctgtat cctctttcca 1936201 tcacttgaag aggacttagt gcattcagct tgccaagaac ggtttgaaat tgggaatgca 1936261 gctgcttcat ttggatattc atattttttc tcagctgatt tgtttgttcc tggtatcgtg 1936321 ttctcgcttg tttcagctgt tcatgaggat gcaatgcctc taatctgtac gtttcacgct 1936381 ccagctgtct gcttttccga tctaaaagag cggtcagctg tgcttgaaac tgctggtacg 1936441 cgaggtcaaa ctgctgctct ttttgcgcat acaaacgctt tggaaaacga aaggcatagg 1936501 acgattgcag cgtttgtatc cgttcttttt tctggccgag atgctgctgc attgctcttg 1936561 tcattctgac ttccgctgtt tttgtccgtt cgattaaatc agtggtatga ggcacagcaa 1936621 tctcagctgc tcctgtcggc gtcgcagctc tgatatcggc gacaaaatca ctaatcgtaa 1936681 aatccgtctc atgtccgact gccgatataa tcggaatatt ggaagcaaag atggcgcgtg 1936741 ctacaatttc ttcattgaat gcccacagtt cttctatcga accgccgcct ctcccgacaa 1936801 ttaatacgtc gcaaatctct ttttcatttg cctcttcaat gcgcgtaacg atggatctgc 1936861 tcgcattttc accttgtacg agcgctggaa gaacaatgac ttttacaagg ggatatcttc 1936921 tttttagagt tgtaataacg tctctgacag cggcacccgt tggagatgtc acaaccccga 1936981 ttgtggctgg aaatgcgggg atttgttttt tgtagcggtc gtcaaataaa ccttctccgg 1937041 caagcttctt ttttaattct tcgtacgcta aataaagcgc tccaaccccg tcaggctgca 1937101 tttctttggc atataattga tagtttccgc tcggttcata tacggaaatt ccgcctctga 1937161 ccagcacttt cattccgttt tcaggtttaa aaggcagacg ctcgctttgt ctcgcgaaca 1937221 tcaccgactg cattcttgcg ttttcgtctt ttaaagtgaa ataaatatgc cctcgtgtgt 1937281 gtatctttac attcgacaat tcgcctttaa tccaaatatt ttcaaggtga ggatctacat 1937341 cgaattttcg ttttatatac tttgtcagcg ctgagacggt cacatacgct gcttcaccca 1937401 tgtctaaaaa ctcctctcct aagcattcct gcaccataac taaagaaaac ccgccctggc 1937461 tttaggagcc tgaagaagcg ggtatcgtgc tcatattcaa ggcgggtaaa catttcgcct 1937521 gtgaatatct ccaattatct atgataacgt acgtttcgca gatttaacag tattatgcgc 1937581 aagcatcgtg atggtcatcg gacctactcc gcccggaacc ggcgttatga aggacgcttt 1937641 ttcctttgcc ccttcaaatt caacgtctcc gcaaagcttt ccgttttcca gacggttaac 1937701 gccgacgtca atgacaacag cgccctcttt gatctggtct gcactgatga agttggctct 1937761 gccgactgcc accaccagga tgtccgcttt tttcgtatgt tcagtaatat tttctgttct 1937821 tgaatgacag taagtaaccg tcgcgttttc atttaataaa agctggccga caggtttgcc 1937881 gacaatgttg cttcggccga ctacaacaac ctctttaccg gaaaggtcaa tattggtttt 1937941 cttcaaaagc tcaacaattc catgaggcgt gcaaggaaga aacgtatctt cgccaagcag 1938001 cattttccct acgtttaacg gatgaaaacc gtctacatct ttatcagggg agatacgttc 1938061 gatcaccgct ttttcagaaa tatggtctgg gagcggaagc tgaacgagaa tgccatgaaa 1938121 ctcagggtct tggttatatt gatcaataat ggaaagcagt tcagcttctg tgaggctgct 1938181 gtcaaattga tcgagcttga aattcattcc cattgtttct gccgcttttt tctttcctcg 1938241 cacgtaagag tgagaagcag gatcatctcc aatcaaaata accgccagtc cgggagtgac 1938301 gccttgcttt ttaagctctt ctacctcttt tgccaattgt tcgcgttttt ctctagccgt 1938361 ttcttttccg tcgatgattg ttgcagtcat tttctttcct cctatgattg ttcaatatca 1938421 gatttaatgt tagaaagaac cccgtttaca aactttgtcg ctttgtcatc accaaaccgt 1938481 tttgccagct caatcgcttc gttcatggag acattcaccg gaatgtcttc ggcatatgcc 1938541 atttcatatg ctgccaggcg caaaatcgca cggtcaacat tggcaatccg atcgagcttc 1938601 caattcacca gatgcttgga gatcatttca tccagctggt cttggtgttc caataccccg 1938661 tgtacaagct gttcaaagaa aggatctgtt ttttcttcat ccagtgcgtg ttctatggct 1938721 tcattcactg caatatcgct gacatcaatt tgaaatagtg cctgcaaagc tttttctctt 1938781 gctgttcttc ttttcatttt ctttctcctt tgatcctctt tatccgcttg tcgttaagcc 1938841 acaaagagat cataacatat ttttttcgta tccgcatatt gaaatcaagg tttttttacc 1938901 ctattaccga atattttcac acaccttaat atgattattc ggatttcacg ttcatgaaga 1938961 aactcggcta tgtaagccgg ctttcttcat gctttgaaat aaagggtaac gtgtaaaaaa 1939021 accaaagggc cgccctcccc ttggtttcgt gttaagccat ttacatttct tcgtcgattt 1939081 ggacttcttg ggcttttgtg tcaaattgaa tgccgacgat gtgaatattg atctcgttaa 1939141 tcgaaagaga cgtcatattt aataaggttt gacgaatgtt ttcctgaacg gatgctgcaa 1939201 ctttcggaat cgaaacgcca aatgtaacga cacagtatac atcgatcgta attccgtcat 1939261 ccgccaggtc gactttgaca cctttgccat gattcacttt gccaaagcgc tcaacgacgc 1939321 ctgtcgcaaa gtttccgcgc atttcggcaa ctccatcaac ttctgatgct gcaatgccgg 1939381 caatgacctc aatgacctcc ggtgcaatct caaccttacc caaatgcgta tcttcgtgat 1939441 ccattttaag caagctgttg tctttcattc aattcacctc cgtaaaaatt atgagcccat 1939501 tacatcatat gtttctaaaa atttcgtatt aaactctccg ctcacaaatg tttcgtgttc 1939561 aagcagtttt aaatggaaag ggattgttgt ctcaatgcct tcgatgacga attcgctcaa 1939621 tgcgcgcttc atgcgggcaa tcgcttcatc tctcgttttt ccgtatgtga ttacctttgc 1939681 aatcatgctg tcatagtacg gtgggatgga atagccaggg tacgcagctg aatcgacacg 1939741 gacaccaaga ccgccaggag gcaggtacat tttaatttca ccaggtgacg gcatgaaatt 1939801 tttgcttggg ttttctgcgt tgattcggca ttcgatggcc cagccttcaa attcaacatc 1939861 ttcttgcttg aggctcagtt ccattcctga agccactttg atttgttcct tgatcaggtc 1939921 agttcccgtc accatttctg tgactgggtg ctccacctgg attctcgtgt tcatttccat 1939981 gaagtaatag cgctgttcat tgtagtcata gataaattca actgttccag cacctgtata 1940041 gccaaccgct ttggcagcct ttaccgctgc atctcccatt tgctccctga tttctgaatc 1940101 aagggcagga gatggtgatt cttccaaaag cttttgcagg cgtctttgga tcgagcagtc 1940161 gcgttcgccc aaatggatcg tatttccgta gttatcagca agcacttgga tctcaacgtg 1940221 gcgaaaatct tctatgtatt tttcgatgta tacacctgga ttcccaaatg cagttgccgc 1940281 ttcctgctgt gtaatcttaa tgccattaat cagttcctct tcagtgcggg caaccctaat 1940341 tccttttccg cctccgcctg cggtggcttt tataattaca ggatacccaa tttcattagc 1940401 aagcgaaacc gcttcttcca cattttctat aattccctgt gaacccggta cgattggcac 1940461 gccggcctgt ttcatcgttt cccgcgcaac gtcttttgtt cccatttttg aaatggcgtc 1940521 agcgctcggg ccgacaaacg tgacattcac ttcttcacat aattcagcga aatcagcatt 1940581 ttcagctaaa aatccgtatc ccggatgaat ggcgtccgtg ccagtcagct ttgcaacact 1940641 cacaatattt gtaacgttta aatagctgtc ttttgatgct ttcggtccga tacaaaaagc 1940701 ttcatcggcc atttgaacat gaagggcatc tttatcagct tctgaataaa cagcgacagt 1940761 ctcaattccg agctctctgc aggctctgat gattctgaca gcaatttctc ctctgttggc 1940821 gatcaatagc tttttaatca tgttcagtct ccttactccg cttttacaag aaatagaggt 1940881 tgtccgtatt cgaccagctg gccgttttct actaatactt caacgatttc gcctttcact 1940941 tctgcttcga tttcgttgaa aagcttcatc gcttctacaa tgcagacaac tgtgttttca 1941001 tttacttttg aaccggctgt tacatacggg ccagcttccg gtgatgaaga agcataaaat 1941061 gttcctacca ttggtgaagt gattttatgc agattctcat cttgctttgg tgcttcttgg 1941121 gcaggtgccg ctgcttgctg cgcttgcggc tgaactgcct gcggagcctg tgcttgtaca 1941181 ggtgctgccg gtgcctgctg catgacttga accgtgcctg cttcgtgttt tttcagtttt 1941241 aaggatacac cttcattttc atatacgaat tcgtcaattg tagactcgtc aattgcttta 1941301 atcagctcgt ggatttcttt gatatttaac attcaatcgc actcctatgt atgaaatttc 1941361 tttttttata ggttactact aaaagtacat actatgttca tcttacagga gcggactttt 1941421 gaattcaact ctaatatgac agcaacgcaa aaagcccgct tgtttagcgg gcttttttcc 1941481 ctcattctta tttagagggt tcaaatgtga cagcgacatc tttcattgtt ttgatttctt 1941541 ttgccacaag gtctataatg gctgtcgcct tcgatttaga gtgtttgtct gatttgactg 1941601 taatattgat tttatctcct tcagcattaa caagcgcatc ctcgtaacct tgtgttttaa 1941661 tcagcgtttc cagctgtttt tctgttcctt ccacttcact gagagccgtc attttatcgt 1941721 atgcttcgct tttctccttg gctgttgcat catcgcttga cacaatggca ttcagctctt 1941781 ctctttcttt gcttctggca tcttctaaat caagacggta cgttgtaaac aaatcatcat 1941841 cggctgtttc cgtaacaaca gttccttttt cactggcttc agcggatgtt tccttgtctg 1941901 ctgatgaatc tttcgttccc tttgttccat cttcttttcc tttttcagtt tctgtaccgc 1941961 ttttttcctt cgtgtcttgc ttggcaggcg ctttttcagt tgcgacctct ccgctgtcag 1942021 acgcgctttt ttcactttgc atctgcacgg cgtttttgct ttccggcgac atgatatagt 1942081 agacgcttaa caccacgaca agactgagca ttgttaatag ccaaacggtt tgttttttaa 1942141 gcatttatga atcctccttt atttttttag gggcaaccgc aacccggtgg cttggaacat 1942201 ccaggacccg tgtcaccgct tcgataatgg tttgttttat ttgaacgttg tccactcctt 1942261 gagcaacaac gagtacaccg cgtatatcag gttttttcgt ttggacgacg acaggtgttt 1942321 ctttatcgcc gtttttgatc atgacgattt cttcctccga tgattggtct gtaacgcttc 1942381 tttttccgcc ttctttgtca gtttcttcag tggttgtatt tttgtttgat ttgttttttt 1942441 cgtatacttt cagcgacgtt gcatctacat tcacgacaac cgagacatcg tccacaccaa 1942501 tgattgtttc aagaatttct ttcagttgat tttcgtattc tttttcatag tcatcgatcg 1942561 agtctttagg tttatcagat tttgaggctt taaacacttc ggctgttttc tctttgctgt 1942621 ctgcggaatg ttgtgatgat acggccgtta tcgttttggc gttttcagtt ttctcaggtg 1942681 aagaaaacag ctggctgaca agcataaagg aaactccgag aacaaaaacg aatagaaagt 1942741 aatgatattt ggtcagcttc ggcttttcgc cgtccttcgt ttgtcccgga agaaactgct 1942801 ttttcaatac attccataat ccgtttttat tcattgccga cactctcccc gccttccata 1942861 tgaaccgtaa ttttctcact tccgatttcc caaatgtccg cgagctgcgt ttgtatctgt 1942921 ttggcttctt tttgttcggc tgcttctttt gttacgtatg catgatctgt atcaatgtgg 1942981 accggcgcga ccgtttggac cgttttttca gaagacgggg ccatatacac gctgattgtt 1943041 ttaatatcct cttctgaatc taccttttct cctgccgtga gtttgatgcg gcctacttta 1943101 tattcatcat gactgaatct ctcctccgct ttctttttta gttggacagc catttcttct 1943161 agaatatatg cgcgctggga agcttgtatt tctatttttt ttgaattgat ttgatttttt 1943221 atgtcggcag actctgactg cccgtttttt gtgaggtatt caaagatgac ttcggggtct 1943281 gtcttgaaaa gtttaaaaat cggcgtaagc atgacgacaa tcaagagcag gctgactacc 1943341 atttttgcgt acttttgcat gctggagctc ggcagcagca tatcaatcac aattgcaaat 1943401 aggataaaca acacgatggt ggtaagccat tccgttaaaa aactcatttg cctgcctcct 1943461 tcatttcatc atcatcgtga ggtttccggc tgtgattatg acagtaaggc ttaaaaaaaa 1943521 catgagagac acaatggcga gagctgcaaa aatataaatg acgcttttgc tgatgacgtc 1943581 gaggcaggtg atgacgggcc cgcctcctag cggctgaaga atcgcggctg ccagcttata 1943641 aataaaagcg agggaaagca ctttgattgc cggaaatgcc gcaatacaga tcaaaatagc 1943701 gacaccgaga atccctaccg tatttttcag cagtaaagag gcgctgatta ctgtatctgt 1943761 tgcgtctgta aacattcggc caagcacagg aataaaattt ccggttataa atttagccgt 1943821 cctgagcgta atgccgtctg tcactgcagc tgacgctccc tgaacagaga tgacgccgag 1943881 aaagatggta agaaaaacag ccagtgctcc gatggcgata tttctgagca ggttagccag 1943941 ctgcgttact ttgtattgtt cagtcatcgt gctgacaatg ctcagaatcg ctgataaaaa 1944001 aatcagcggc atgacgatat tctgaatcaa gagaccgctc gtgttcatca ggaagaggat 1944061 aacaggatga aagaaggcag cagatacagc tccgcctgag gaagccaaaa gcgccaagag 1944121 gagcggaatg agcgccagga taaagctggt catcgtctga atcgcctcag ttgcatagtt 1944181 aattgccaca tgaaagctat taagcgcaag gataatcagc accatgtaca caattgagta 1944241 agcgacctta ctgacggtgc tttgctgaaa agcattttgc aaaagctgca gaatgacgca 1944301 aaaaatcgtg agcaaaatca atgtgcccag cagctttccg ttggcaagca cttcatgaaa 1944361 caaataagaa aagagagctt tcagccattc ttgcggtgag aatgatttat cgccattgat 1944421 aaactccatt aagctgcctt tttggctttc cggcagcagt ccgccgtatt ctgtcataat 1944481 gtcattccaa aattccccga tcttatctgt ttcaagcgag gctgctgtcc tttccgctaa 1944541 ttgctcggct gtttcagcat ggtcttccgt ttgttctgca ttaccagctg cttgtacaat 1944601 ttctgcacgg cctgctatga tcagcacggc caaaagcaaa acccattgaa agcgcttcaa 1944661 tctaccgcct cctttcggtt atgacataga aggtataagt ccgagaatcg tttcgataat 1944721 gacggttaaa ataggcacag ccattacgag tattaaaatt ttccccgcca attctatttt 1944781 cgaggcgatg gctccttgac cggcatcttt tgtgagctgt gccccgaatt cagcaatata 1944841 ggcgattccg ataatcttta aaatggtttc aacatagacc atgttgacat ttgcattaat 1944901 cgcaattttt tctatcattc gaataatgtc gtagatttgg tctaccaaat aaagaaaaat 1944961 ggcacatccg gcaaaaacga cgattaaaaa cgcaaaagtc ggcttttgtt cttttacaat 1945021 taaagaaagg aaggtggcga tcagccctaa acctacaatt tgaacaatgt caatctgcaa 1945081 gcccccctat ccttggaata aaaacacagc ttttatcttt ttaaataggt catctacaat 1945141 cgtggcgacc ataaataaaa tatagataaa acctaacagc gtcacccact gagcatattc 1945201 tttcttgccc atctgatcca atatcgtgtg taaaaaagcg accacgattc ccactccggc 1945261 gatttgaaat atgacattca cgtctactcc cattttattt ttgctcccct cacgtttaca 1945321 tcaatagaag aatgagtaac aagcccgcta aaaagcccaa actttttatc atcttttcgt 1945381 ttttcgcttg cgcctgctca gcatccgctt ctgaggcttc caaatgtgtc agcgccagct 1945441 tgatgtgctt ttgctgagag attcgatcat gaatcccaag cgtctcgcca aactgcttca 1945501 gcacttcgta ttcgcttttt ttcaaagaca gggtgtccca taccttcttt aagctttgct 1945561 cccacgccgt tttcgcggaa tcacttccct tgtccagctg atcactgaat gcggaaaaaa 1945621 gagttgaaac aggctgtgcg agctgtttgg caatctgctg tgaagcagta tgaagcggtg 1945681 tatggccgta catgatttca gcctcgaggg attgaagcgc cgcacgcagc tggcggattt 1945741 gccgcggccg ttctgtataa atcttcgcca tctcaaaacc tgtccatgtt gtcgctacca 1945801 caatgaatac agcgcccagc agcttcagca tgttttcacg cccgtcgtcc tagacagcac 1945861 atttccgtct ttgtcataaa tttggctcac tgtgcccggc ccttttgctc ttgataattc 1945921 caaatagcgg tcaaaggctc tttcttccca caaacgcttc aatgaaggcc gcttcatcag 1945981 gtcggatata ctccagccat gcgccgatac gattactgaa acaccggcat gcagcgcctc 1946041 cagaagtgca tctgtatctt ccatacgccc gatttcatcg acaatcatca cctcagggct 1946101 catggatcga atcatcatca tcagcccttc agcttttgga caggcgtcta acacgtcaat 1946161 tctctgacca aattgatgct gcggaatacc gcgaagacat ccggcaatct ctgaccgttc 1946221 atcgacgatc cctgtcttta cgggcagcat gttttttttg ccggtgcttg agagcctcgc 1946281 aaggtcccgg agaagtgttg ttttgccggt ttggggcggt ccgataatca gcgtattcag 1946341 ccagctgttt tgatataagt atggaagcag cggctccgca atccccagct tttgccgggc 1946401 aattcgtata ttaaaagatg cgatgtcacg gaggcctttc acacctccgt tttccgtaat 1946461 gactctgccc gccagtccga ctctgtggcc gcctctgatc gtgacatacc ctttcttcag 1946521 ctcttcttca agtgtataca tactatagtt gctgagccgg ctcaggatca gatgggcatc 1946581 ctcggccgtg cccgcatagg acaaataaac aggttgtcct cttcgaatca attcaacagg 1946641 gcggttgatc cgaattctga cttcttcgat ttccagccat tgttgttccg gtatttcaga 1946701 aagggcgttt ttcatggatt cagggagaac ctcagcgatt tcattcaaca gagcctcctc 1946761 ctttctaccg attggcttct ttaaaatgta tgatgtgagg cagactttat gacaagcctc 1946821 tctttattta tgaacacccg ccaaaatcaa gacaacaccc gtaaaaatca gaatcagctt 1946881 tgcatacgaa agctgcccgg caatttggta gattccgaca gtcattgtaa tgataaaaat 1946941 caacggaccg acaatagcga gaatgctgtt aaccacaacc gccttccgga catcgttggt 1947001 cacaagcatg acaattgctg ccgtcagctc aatcatagag gataaaactc gtaatcccgc 1947061 cattgttaaa acagtagaat tgatatttcc aagtaaaaat ttcatagcac tctcccaacc 1947121 tcccattttt ttatatgata tgctctagct tgctgaagta gtcttgtcat tttcgtataa 1947181 aagaaagatt ctgtttttgg gcacaaaaaa agcctgctcc catttgggaa cagacttctt 1947241 tttttctttc tatgctcttg aaacgtaaga accgtctgat gtattgacaa caagtgtgtc 1947301 gccttcattc acaaagaacg gcacgtttac aacaagcccg gtttcagttt tcgcaggttt 1947361 tgtaccgcct gacgctgtat cacctttaat accaggttca gtttcaacaa ctttcagctc 1947421 aactgtgttt ggaagttcga taccaagtgt ttcatcctgg tacatcatga tatgcacaga 1947481 catgttttct agcaggtatt ttaattcttc ttcgatttga gttgcgctca gttcaagctg 1947541 ctcataagaa gaagtatcca taaatacgtg ctgatctccg tttgcatata gatattgcat 1947601 tgttttggtt tcgatttgcg ctttcgctac tttttcacca gcgcggaatg ttttttcctg 1947661 aatcgcgcca gtgcgaaggt tgcggagttt agagcggaca aatgccgcac cttttccagg 1947721 ttttacgtgc tggaagtcaa cgacgcgcca aatgccgcca tctacttcaa ttgttaatcc 1947781 tgtacggaaa tcgttaactg aaatcatgtt taatgtcctc ctatattcca atcacaaaat 1947841 aataagttct tttggggaat gggtgattgt ccggttgccg ttttctgtaa tcacgatgtc 1947901 atcttcaatg cggacaccgc ctgtttctgg tatgtaaatg cccggctcca ctgtgaccac 1947961 catacccggt tcaaggatag ctgaagatct gacggataat cccggcgatt catgaacttc 1948021 catgccgagc ccgtgcccgg ttgaatggcc gaaatagtca ccgtagcctt ttgcagcaat 1948081 atgatccctt gtgagggcgt cagcctcttt tcctgtcatt cccggcttaa tatgtgcgac 1948141 gccaagcgcc tgagcatcaa atacaacctg atagatctcc ttcaattgat cactgggctg 1948201 acctacagcg accgtccggg taatatcaga acaatatcct ttataataag cgccaaaatc 1948261 aagcgtaaca aggtctccgc tttcaatcag tttgtcactg gccacaccgt gcggaaggct 1948321 tgaacgaagg cctgaggcga caatcatatc aaaagaagag ctgtctgctc cctggcttct 1948381 catataaaac tccagctcat tggcaacagc gatttcagaa atgccgggtt tcataaacgt 1948441 caagatatgt ctgaaggcat catctgcaat cttcgcagct tcctctaata tcttaatctc 1948501 ttcactagac ttaatcaagc gcaacttttc cacggattca gccacaggca ctaattcggc 1948561 atcactgata acggcgctgt atgaagcgta agtgccatat gtcatgctgt tctgttcaaa 1948621 gccgagacgc ttgatgccaa acgattcaac agtgtcggca gtggtctgaa tcaagctgcc 1948681 gccatgttca atgatctcaa aaccctttac ctgaaccttc gcctgctcag tataacgaaa 1948741 atccgtaata aacgctgctt tgtcacccga tataacagcc aaacccgccg aacctgtaaa 1948801 ccctgtcata tagcgtacat tagtgttgct tgtaatcagc atgccgtcaa ttcccagctg 1948861 tccaaacagg tttcttaatt tctctagctt catcttgatt ctcccccttg ctggcttaat 1948921 aagtagcgaa cagcaagctt gtagccttca gctccaagac cgacaatctg ccctttcgca 1948981 acaggagcga taaccgactg atgcctgaat tcttccctgg cgtataagtt tgataaatgc 1949041 acctctacca caggaagact gatgcttgaa acagcatccc tgatcgcata gctgtaatga 1949101 ctcagggcgc cggggttcag aacaatcccg ctgtattgct cctcagcctc atgtatcgca 1949161 tctatcaaat caccttcgtg attagactgg aagaaagtga gctggatatg taaggcttca 1949221 gcaaactgaa aaagatctgt ttcaatatcg gtcagtgtct ggcggccgaa tacttcaggc 1949281 tcacgactcc caagccggtt aacattcggt ccgttcaaaa tcaaaaaatg aggcacacaa 1949341 tctctccttt tcgcgagggt ttctcatgta aaaaatgttc acttctcgtg aacattttat 1949401 catactggaa aaggattata cactattctc tatgcattcc cagcgcacgt gcaagctttt 1949461 ccgaattcag ctcattgtat tcaaatgaaa tagaataccc gacaaacagc ccgtaaagca 1949521 aataaatgca aatggtcgta ataattgtat ctgatgtcag ttcggtcacc gtgcgcacat 1949581 ctggaaaaat cggattaaaa acaaaaaaca cgagcagcca aagcaccaag ccgtataaaa 1949641 tacccggcca cattgttttt aaacgtttca atagaagaaa ataaagaaat gctgcgccaa 1949701 ttgaaattac tccaatcaaa atgatgctga ttaccgttcc cagcccatgt tttttccact 1949761 ctccgagtac aaacggctgc aatatcatat tcgggctgat ttcggaaaaa tgaaacaaat 1949821 atgcgatata agcaacgaaa ctccaaagta cgcctccgca aaaacctgtt gccgccaccc 1949881 tgccggccat tgaaacaggc ggcttttgct tctcattcaa ttcttcattt tgttctgtat 1949941 ctttttcgct tgtcatcatg gcacctccag ttaaagtgtg cccaaaaaat gaaatgtcaa 1950001 taaaaaagct cacacttttt ggcagctgcg agtaaaattt gaaaataacg ggtataatgc 1950061 atgtagaaaa agcaaggcta tggcaatttt ttcagcctgt caatctagag gtttagcgct 1950121 gtttcctgta caatagagtg aaaggaaatg gttagcaatc ctaaagaaat aggcaggttg 1950181 ataatatgtc aaaacataaa gttccgcccg cttacggcgg gcaggctgtt gtggaaggcg 1950241 ttatgtttgg cggaaagcat cattacgtta cagccatcag aagaacggat ggaagcattg 1950301 acttttttaa gcttccacgc aaacacaacc cgaaactgaa catcgtgaaa aagataccgt 1950361 ttttacgggg gatcgcggcc attatcgaag cgagtgcaaa cggcacaaag catttgaatt 1950421 tttcaagcga acgttacggg ctcgatccat ctgaagacga gacacttgag caggaagaaa 1950481 aaaaatcctc tgggctgtct atgtatctca gcctcgcagt tataggcgtc ctatcatttt 1950541 tgttcagtaa attcgtattt acattggttc cagttttctt agcggaactg acaaggccga 1950601 ttttttcctt gaacacagcg caaatcgcga ttgaaagcct gtttaagttg attttgctgc 1950661 tcggttacat ctattttttg tccatgacac cgcttattaa aagagtgttt caatatcatg 1950721 gagccgaaca taaagtcata aactgttatg aacagaattt gccaattact gtggagaatg 1950781 tccaaaacca atctcggctt cattaccgct gcggatcaag ctttatttta tttacgatta 1950841 ttgtcggcat gtttgtttat ttactcgttc cgacagatcc gctttggctg cgtgttatag 1950901 atcgtgtcgc actgataccg gtcgtgcttg gtatatcctt tgaagttctg cagctgacaa 1950961 acaaagtgcg tgacattccc ggtctgaaat tacttgggta cccgggactt tggcttcagc 1951021 tgttaaccac aaaggaacct aaggatgaac aggttgaagt tgccatcgaa agctttaacg 1951081 aacttctcag actcgaagca ttgtctgagc aaaatcagaa gccttctcac aacgtcatct 1951141 aaaatccgtt gccctgctat tactttcgga ggtggacagt tatgaatcat cgtgtacaac 1951201 ctattattgc tgtattaatt gcgctgggag cgttcggttt cctctatgtg ctggtaacca 1951261 atcccggaga aatggcaaaa atggcggtaa ccgtcatcgt ggcaggtatc attatttatt 1951321 ttattgtgaa atatgtaatg aatcgaaatg cgggcagcga aggagcagcc ttcaaaaaag 1951381 cggcgaaaca atcacggcgc cggatgaaag aacaaaaagc aaaacaccgc gccggacata 1951441 agggacgtgt cagccacctg cgaagcgttc cgagcgccag caagcctaag ccgatgattc 1951501 tcaagaaaaa aagccagact cagctgactg ttatagaagg gaaaaaaaat aaaaagaaaa 1951561 acagagcgct tttttaatag gtccactgct ttaaaaacag ctctgtccgt cttttaccta 1951621 gctcaatcag ggctagtttt ttttgttgtg ttaaatgaaa atcagtggcc attacgtcat 1951681 caacagggag aaaaatgata ttttgttcat agcgtgacgc aatgtgcctt gcgtcatgag 1951741 catccttcat cgtttcaaac agggcgccga acagttcaaa agcgttgcgg atattttttt 1951801 tcggacgctc tctttcacgc ggcgcaagcg tgacaccgat cacagggcgc tttctttcct 1951861 ttgaaaacag ccagattgga aaattgctta acacgcctcc gtcgacaacc gtggcggtgc 1951921 ctgtgtccgt ttttaatttt atcggttcaa agaaatacgg aatgctgcag ctcattctga 1951981 ccgctctggc aaccgggaac atatctggat ttaacccgta acgggccaaa tcgtccggca 1952041 aaacaatcat ggtgccgttt gtcagatcag aagcaataag gcgcagagac cctttctgca 1952101 aatcgccgaa aacccttatg cctttcgctc ttaacagatc agcaatccat ttttctatcg 1952161 tatcgccttt gtataagcca agacgccagt agatggacac ccactggagc atctttaagg 1952221 ggagaaatga gtacctctga tccagcaatt tctctccgtc cacttcttca attaaagcgt 1952281 ggatttcctt actggtgtaa cctgacgcaa tgaaagcggc aataatggcg ccggcgcttg 1952341 tacccgcaac tcttttaaag cggaagcctt tttcctcaag cacttcataa gcgcctgcga 1952401 gcgcaatgcc ttttactcct ccgccggaaa acacaccgtc aatatacatc tcattccctc 1952461 cccctccatc cgatcgttta ttaccatttt aagaaaacac gcgaagaaat agaccaacga 1952521 atgacgggtg gcgtcagcgt atcaaaaaag acggcctcct tcgagaccgc ctttttactg 1952581 attatgatgt tctgttttct tttggattga tttcagatct tttttacggg catcatcttc 1952641 ttcaaaatat tgaacaagat ccccgatgcg atcaatactg ttccagctta aatgatgttc 1952701 gattccttcg acatcgttat atattttctc ttcatcaaca ccaatgattc ttaaaaactg 1952761 ctcaagcaat tcatgtctgt ataccagccg tttgcctatt tttttccctt tagacgttaa 1952821 cacgagaccg cgatattttt cataaattaa atattcgtct ttatctagtt tttgaaccat 1952881 ttttgttaca gaggagggat ggactgccaa tgcttccgcg atatcggaaa ctcgtgcata 1952941 tcctttttct tcaatcagca tataaatctg ttcaatataa tcttccatac ttggtgttgt 1953001 catcgaaacc ctcccaaaaa gcaccttaac tttataaacc attacaagtt tacactaatg 1953061 aacttgaaaa aacaaggatg ctccgcgggt caaaagccct gtttaccgct tataattcca 1953121 ttcatctgaa gcgtactttg tttcagccaa gtgatgaaca aaatcaagct cttcctgaga 1953181 aagttcatat ggctccaaat gaatgttaag acctgtttca aatccttctt taaaggcttt 1953241 acgagcctca tccatcgtca cccgcttttc gatgagttca ttaatggcaa ccgctttatt 1953301 tttgaaattg cgctgcatcc gctctcttac tctttcactt ggatataaga acagatcgaa 1953361 cagcttgtcc tcatctaaat caagaagaat ggagccatgc tgaagaatca cacctttttg 1953421 tctcgtttgc gcgcttcccg ccaccttgcg cccctcaacc actagttcat accacgaagg 1953481 cgcgtcaaaa caaacagatg accgcggatt ttttaagctt tctttttctt tttcagttct 1953541 cgggatggca aagtaagcgt ccagaccgag atttctaaag ccttgaagta tgccttctga 1953601 aataacccgg taagcctcag taacagtcgc cggcatctcg gggtgctctt ccgaaacaat 1953661 tacgctgtat gtcagttcct gatcgtgcag cacacctctc ccgccggtcg ggcgtctgac 1953721 gaatccgaga ttatatttat gtactgcttc aaaattgatt tcctttttaa tattttgaaa 1953781 ataccctaca gaaagtgtcg ccggattcca gccgtaaaaa cggataaccg gggggatttt 1953841 cttttcgctg tgccaatata aaagcgcttc atcaagcgcc atattgaatg caggacttgc 1953901 attgcctgag tctataaacc gccaagtttc tttttgcatt ttaagacctt ccttaccgtt 1953961 ttaatagaat cagtttatca aactgtcggg aaaatgaaaa atattttagt tccattatag 1954021 atgacaatca cgctgtgctt tactataata gtatttgtcg aaaacggctc tatgaccttg 1954081 ttttatgaag cagggttttg attttatatg ctaaaggagt agaatcacat tgtctaatat 1954141 gatcgttttg attatttttg ctgcatttat catctatatg attgcttcat atgtctatca 1954201 gcagcgaatt atgaaaacac ttaccgaaga agaattccgc gcgggttacc gcaaagcgca 1954261 gcttattgat gttcgtgagc caaatgagtt tgagggcgga catattttag gcgcccgcaa 1954321 catcccgctt tcccagctga aacagagaaa aaatgagatc cgtacggaca agcctgttta 1954381 cctgtactgc caaaacagtg tccgcagcgg acgcgcggca caaaccctgc gcaaaaacgg 1954441 ctgcactgag atttacaacc taaaaggcgg ctttaaaaaa tggggcggaa agattaaagc 1954501 gaagaaataa agcaaacagc tgtctggtag acagctgttt ttatttatct ttcttccgcc 1954561 tcgtatctga gcactgggtg tctcgccgct tttgtttcat ccattctttt tacaatcgtt 1954621 gtatgcgggg cctcctgaac aagctccgga ttctcctccg cttcttttgc gatttgaatc 1954681 atagcatcaa taaacgcgtc cagtgtttcc tttgattcgg tctctgtcgg ctcgatcatg 1954741 atgcattctt caacattaag cgggaaataa atcgtcggcg gatgatagcc gaaatcaagg 1954801 agccgttttg caatatcaag cgtacgcact cccagctttt tctgccgctt ccctgataat 1954861 acaaattcat gcttgcaatg gcggtcaaac ggaagatcgt aataaggcgc gagttttctc 1954921 atcatataat tggcgtttaa cactgcgttc tcagtaacag cctttaatcc gtcaggcccc 1954981 atggagcgaa tatacgtata cgctctcaca ttaatgccaa agttgccgta atacggcttc 1955041 acacggccga tcgcatgagg gcggtcataa tcaaacgtaa agcgcccttc ttttttgact 1955101 aaaactggct ttggcaaata aggaatcaga tcttgtttta cgccgacagg gcctgagccg 1955161 gggcctccgc cgccatgagg gcctgtgaat gttttatgca ggttgaggtg caccacgtca 1955221 aatcccatat caccaggtct cgccttgctt aaaacggcat ttaaattagc gccgtcataa 1955281 tacagtttcc cccccgcttg gtgtacaatt tccgccatct ctgtaatctg ctcctcaaac 1955341 aagccgagcg tgttcggatt cgtcagcata agagctgcag tttcttcatt cactgctctt 1955401 tttaaatcct ctaaatcaac aagccctttt tcattcgatt tcaccgtaac ggtttcaaag 1955461 cctgctactg ttgctgatgc aggattcgtc ccatgcgcgg aatcagggac aatgaccttc 1955521 gtccgcttga aatccccgcg agcttcatga taggcacgga tcatcatcag ccccgtccat 1955581 tcgccgtgcg ctccggcagc aggctgaagc gtaacctcat ccattcccgt tatttcttca 1955641 aggtgtttgc ttaaatcata taaaagctct aatgcgcctt gcaccgtgtc ttcatcctga 1955701 agaggatgaa tcgcagcaaa accaggaata cgtgcgattt tttcattgat tttcggatta 1955761 tatttcatcg tgcaagaacc gagaggataa aaaccggaat ccaccccgtg attgcgtttg 1955821 gacagcgctg tataatggcg catgatgtcc agctctgaaa cctccggcag cgctgcgtct 1955881 tcgtcacgaa tataggtgtc tgacaagagg tcccccaatt cgatttccgg tacatcgagc 1955941 tccggcagac tatagccgat tcggccttct cttgaaagtt caaaaataag tgcctggtcc 1956001 tgattactca tggcgatccc ccaattcctg aatgagtgcg tcaatttctt cttttgttct 1956061 cagctctgtt acagcaatca gcatatggca gtccagctct ggatacgtca acccaagatc 1956121 atatccgcca atcatgcctt ttgccagcaa acgcttgttc acagctctca ccggctcatc 1956181 cagtttgatg acaaattcat taaacatcgg cccgtcaaac ataacagtaa ggcctgcttt 1956241 ttttgcttct tgctttgcat agttggcttt taagagattt tggcgggcta tatcttttac 1956301 gccgtttttt ccgagagcag tcatggccac tgatgctgcc agcgcattta aagcttggtt 1956361 cgagcatata tttgatgttg ctttatcccg gcggatatgc tgctccctgg cttgcagggt 1956421 aagcacaaag cctctttttc cgttttcgtc ttccgtttgt ccgacgagac ggcccggcac 1956481 ctttctcatt aattttttag taacggcaaa aaagccgcaa tgcgggccgc cgtatgctga 1956541 aggaatgccg aaaggctgcg catcaccgac gacgatatca gactgaaact tgcccggcgg 1956601 agtgagaaga cctagcgcca gcgggttggc tgaaacaata aacatggatt tcccttgatg 1956661 agcgataggc tcaatatcct ttagcggctc gatcctgccg aaaaaattcg ggtactgaac 1956721 gatcactgcg gctgtgttct cgcaaacggt ttggcgcaat gcatcaagat ccgtaacgcc 1956781 atccgcagcg ggtacttcaa caacatcaat atactgacct tttgcgtaag ttttcagcac 1956841 ctctcgcgat tcaggatgca cggtttttga cacaacaatt tttttctttt tcgtgtggcc 1956901 tgaagcaagc attgctgctt ctgccaaggc tgttccgccg tcatacatcg aggagttggc 1956961 gatatccatg cctgtcagtt cacagatcat cgtttggaat tcaaaaatag cctggagctc 1957021 tccttgtgaa atctctggct gataaggcgt atatgcggta taaaactcag agcgcgaaat 1957081 gacatgatcc acaatgacag gctgatagtg gtcatataca cccgctccta agaaagaagc 1957141 gtattgtacg gtatcacgat ttttagaggc cagctttgtc agttctcttg ttaattctgt 1957201 ctctgatttc gcttttttga tttgatgctc ttttttatat ttgacgtttt ccggtatatc 1957261 agcaaataaa tcatcgatgc tgcttacgcc gatagtagca agcatctcct gtttatcctt 1957321 ttctgttgcg ggcaaataac ggtgcttcat gtgttgtctc ctctctccaa gaaaaaatat 1957381 tagcgtttat aaaatggtgt tttgacaacc tttgctttca ctaatttttt gcgtatctct 1957441 acatctacaa cagtcccgat ctcactcgtt tccgaatcaa ttaaggcaag gccgacgttt 1957501 tttcctaatg tcggtgactg cgtgccggtt gtcacctttc cgacagactt gccattttgg 1957561 aaaacctcat atccgtgccg cggtatccct ttttcaatca tttcgagacc gacaagtttg 1957621 cgcttcgctc cgttttcttt ttgttcactc aatactgact taccgaaaaa gtcagactcc 1957681 tttttgtgct ttacagcaaa gcctatacct gcttcaatcg gtgtaatatc ccgggtcagc 1957741 tcctgaccgt agagcgggag cttcgcttca aaccggagtg tatcacgtgc accgagaccg 1957801 catggaatca atccgtatgc atcccctgca tcgatgattt ttttccaaat atgcatagca 1957861 tcatcactgc ggcagtaaat ttcatacccg tcttctcccg tatagccagt gcgtgaaata 1957921 agtgctttgc ggccgctgat atcggcttca tcaataaacg caaacggctt taatgcagac 1957981 acatccgcat ctgtcagatt ttttaagatc gcttctgctt tcggtccctg tacagccaag 1958041 agcgcgattt gatctgactg attgtcaatc tgcacatcac ctgctgcatg ttctttcatc 1958101 caagccaagt ctttatctat attagaagca ttaatgacaa gcagatagcg gttctctcct 1958161 ttttgataga taagcaaatc atcgacggtt ccgccatccg ggtaacacat cgctgtatat 1958221 tgagcacggc ctggcgttaa cgcggaaaca tcatttgtca tcaatctttg caaaaaagac 1958281 agactgtcgt tccctgacac ttcgacttct cccatatgag atacatcaaa caaaccggct 1958341 gcagttcgga cagcctcgtg ttcttttttt atagaagaaa attgaacagg aagctcccag 1958401 cctccgaaat caatcgtttt tcctccatat tccttataca ggtcaaataa cggcgttctt 1958461 ttcagcatct aattcctccc ctttatcaac ggcgcagcta aaaaacatac aaaaaaggac 1958521 agagaaacac ctcatgtaaa atgaaggttc tctgtcctgg cacctgaaag tttactttgc 1958581 atacgcaaag acgtcccctt tggtggtttg cgcatccgca caaacactct ccagagttgc 1958641 gtcgagcaag agttcttttg cctgagagat tcactccgca gtttgctcct tcggcgcctg 1958701 tatcccgagg ttttcggtca ggtctctccc cttgctgtca ttcgctcata ttttcatgct 1958761 gttatggaca tactatagca atatcttaca tcaaatacat actcatatcc taccatcatc 1958821 actatatgct gggcaacagc aatttgggca gatttttctt atattattca tcttaagaat 1958881 cgaagaataa gaaaggcggt ttcaaagcaa tgaatacaga aatgatctac gatgcaaaat 1958941 ggcctgaaga atttgctgaa agactgaaaa acgatggccc ttgggcaaac tgggaactgt 1959001 acaagctctc tgcagaaatc cagaaaacat tagcaattcc agagtttgaa ggcttacggg 1959061 ctcctttata tctgccttcc tttacgccgc tcccccacca gcttgaagtg gcgcaaaaag 1959121 tggttgaaaa aatgaacggg aaagcgattt tagcagatga ggttggtctc ggaaaaacgg 1959181 ttgaagctgg actgattcta aaagaatata tgattcgcgg gttagcaaaa aaaattttga 1959241 tccttgtgcc cgcttccctt gtgtcacagt gggtcaaaga gcttcaggaa aaatttttga 1959301 ttccggctgt tgaacaaaag aaaagctatg tgtgggagca atgcgatatt gtcgtctcat 1959361 caatagacac cgcgaagcgc tcgccccatc gagaaatcgt tctgtctatc ccatatgatc 1959421 ttgtcattat tgatgaggca cacaaactga aaaatagcaa aacgaagaac tatgaatttg 1959481 tccggaatct cgtaaaaaaa tattgcctgc ttcttaccgc gacgccaatc cagaaccgta 1959541 tcgaagagat tttcaatttg gtgtccttat taaaacccgg ccatttaggc agtcagaatc 1959601 actttcagga ggagttcgcc aagaagaaat ccagtttaga agcgcatgaa catttaaaag 1959661 atcttgtgaa taaagtcatg atccgtaaca ggcggcatga tacagggctg aattggaaac 1959721 agcgccatgt tgaaacagtg ccgattcaat tttctccatc agagcaggcg ctttatgatg 1959781 aaatttctcg tttgaaggac agtatcaata aaccagccag catgttctcg attatgacct 1959841 tgcaaagaga atgctgttcg agcagagaag cggtatatat gacgctgaaa aagatgcttg 1959901 atcaaaaaga gaaacaagca cctgccattg atgaggatac gatttcagtt ttgatagatc 1959961 gcatcaatca agtgacacaa aactctaaag cgcttcaagt tgttgacttg atcaaaaaga 1960021 tcgacgataa ggtcatcatt tttacagaat accgcgcaac ccagatttat ctgcagtggt 1960081 ttcttcagca aaacggcatc agttctgtgc cgtttagagg cggatttaaa cgtggaaaaa 1960141 aagactggat gaaggatctt ttccgcggaa aaatccaagt ccttattgca actgaagcag 1960201 gcggtgaggg aattaacctg caattttgca atcacatgat caactatgac ctgccatgga 1960261 acccgatgcg gcttgagcaa agaatcggaa gaattcacag actcgggcag gagcgtgacg 1960321 tgcatattta taacatggcg acaaaacata cggtggaaga gcatattcta aagcttttat 1960381 atgaaaaaat tcatttgttt gaaaaagtgg tcggtgaact tgatgatatt ttaacgaaaa 1960441 ttcaagtgaa caattttgaa gagcaccttc atgacatttt gtatcactca gcaacagaag 1960501 aagaaatgaa aataaaaatg gataacttaa cctcattttt gtcttataaa aaacagctgc 1960561 ctgctgaaaa aagaggatct tagcctgtaa ggaggtttta ttagtgagac agcaagaggt 1960621 tcacgatttt ctgctgcgtt tttttcaagc aaacagctgc caaatcgtcg atcaaggctt 1960681 aggctatatg acagtgcagc ttacagttga aatggacaaa caaatcatga accgcccttt 1960741 ctactggcat tggcgcgaga agacaggcgg tgatccgaat ccaatgaaaa tcacttttat 1960801 tacagataaa gaaaatgcgc caaaagacct agatggtgaa tttatatatt ttggggcccc 1960861 gcgtcttttt caaatattca aagctgttaa acaaaatggg agatttacca gaatgtatga 1960921 gaaaattgaa tcagccggag ctaaagtccc acttcagcct tggcttggta taaatgtcac 1960981 gatttcatac cagtccgaca tgaaaaagga taagttattg tcactaggtc ttcacctagt 1961041 ctctggaacg ataattgaag attttcaaag caagctgacc cagttttcac tgacgtctca 1961101 aatatgtgac tattgcttca ccatttcacc tatgatcaaa ccagaaagcg gacttaagcg 1961161 tatggaaaac tatatttcca aatccgctat gcaggagccg tccgactggg cggaacaggc 1961221 ggttaacagg tggaagaatg atatgacatt gcttgataag ttttacgagc atatagaaga 1961281 aaaaccagaa gaataccatc tagaaaaaca ggcgctgaaa accttgtatc aaccaaagat 1961341 atcagttgaa attgaaaatg gcggattgtt ttatctgcaa aataatattt caagctaact 1961401 tttttaccat tcgacatcat tctcgttttt tttgagaaaa tacgattata ataaaggtat 1961461 attggaaaaa aattctggtg atttaatggc aaatgacttc cagagactaa tgaagcatac 1961521 aataagtcat ggccggactg gctgaaatac ataaacaagt attttaggag gagaaactgc 1961581 atgaagaatg caaaacaaga gcactttgaa ttggatcaag aatgggttga attaatggtg 1961641 gaagccaaag aggcaaatat cagcccggaa gaaatacgaa aatatttact tttaaacaaa 1961701 aagtctgctc atcctggtcc ggcagccaga agtcataccg taaatccttt ctgaatgtgc 1961761 tataatatca caaggaaggt gatgacattg attggccagc gtattaaaca ataccgtaaa 1961821 gaaaaaggct actcactatc agaactagct gaaaaagctg gggtagcgaa gtcttattta 1961881 agctcaatag aacgaaatct acaaacgaac ccctccattc aatttctcga aaaagtctcc 1961941 gctgttctgg acgtctcggt tcatactttg ctcgatgaga aacatgaaac cgaatacgat 1962001 ggtcaattag atagtgaatg ggagaaattg gttcgcgatg cgatgacatc cggggtatcg 1962061 aaaaaacaat ttcgtgaatt tttagattat caaaaatgga gaaaatccca aaaagaggag 1962121 tagtgcctga gcagaggcac taactcctct tttgtcaata accatcgaga cggcccagta 1962181 tatgaatact gggccgtctc ttttttttgc tgttattaat ttttatcctc gctatgcgcg 1962241 agctcgtctt gctcagtatt gctcattttt tcaatttttt agaaattttt gggattgtta 1962301 tgtgagaatt taaatgcata tcccattatt atttggtaat aataaacaaa gaaagggtga 1962361 cagcatgatg atcaaacaat gtgtgatttg tctatctctt ctcgtctttg gcaccacagc 1962421 cgctcacgca gaagaaacac cgcttgtaac cgcccgccac atgtccaaat gggaagagat 1962481 tgctgtaaaa gaagcaaaaa aaaggtaccc gctcgcacag gtactgttca aacaaaaagt 1962541 atgggaccgt aaaagaaaag atgaagcagt gaagcaatac catttaactc tgagggaagg 1962601 gtcaaaagaa ttcggcgttt ttgtgacgat ttcatttgat ccttatagcc aaaaggtcaa 1962661 taaaattgcc atattagaag aatatcaata aggtcctcca ttttttgaag gaccttattc 1962721 gtttatttgc ggttattttt tccgtttcag ccaaagtcgg aagccatagg gtaaaatacc 1962781 gaaccactgc tgggaaacag gcgtttttgt ttctttccgc acctcttttc gttcttttcg 1962841 ctcatctctc ggagtatcta tatatttgac aaattgctgc gtcatatatt taacataatc 1962901 attcgttttc acgtgatcac ctcatcattc aattattatg agtgttgtct cacatgactt 1962961 tttttatacc ctttacactg ttttattctg tccatctcag cagttttttc tgtttttggt 1963021 caaacacgat ctgtgcagtt ctttctgttc ccgaatccgt tgacactctt aagttgattt 1963081 ctttttgttc ttttatcgat gtatcatgaa tgtaataaga aacccgtcca tatagaaatt 1963141 gctgcgtacc ctcctggcct ttccgttcct ctagaacatg ccgaatcgaa agaagcaccc 1963201 cattttgaag caaattctct cctatgtata actcttttgt ttccttctca aacatgcagc 1963261 gtgaaatata ttgagcagca acaaagttca cgattaacag cacaagcgct gacacaaaaa 1963321 gaacagctgg ataaataaac cctcttgtac gatacattca cccccctcct aaatacgaat 1963381 agactggaaa agcagtttga tacacttttt ggtcttcact ctcaattttc agcaaaacaa 1963441 caccattttc aatatcagct ttcatggcag taatatgatc taaaatcgga acatgccctt 1963501 tgccatccac tctttttctt atcattgaat gataaatgtc aaaacggatg tcttgtccgg 1963561 aaagattggt gcagattaac acgctcccat gctcggctgt cttaactgcc tgtgattcct 1963621 tgcattcatt catcatctgt tctatcgaaa tcatccattc ctgctgtgtg aaaccgtcat 1963681 gttcctgctg tcgagacaaa aacagatgga taatcgcagc taacgatcct gatatgagca 1963741 aaaagactga gagcgaaaat aatacgttaa gaagcgtgta gccattctgt ctgcaaaatg 1963801 ctgaggcaaa atgatttttc tttataagct gcggctttga tacatacgtt ttgatattcg 1963861 ccctcctcct cccacttcat tgcatagata tgattgttct ttgtaatcgt ttttgacgcg 1963921 gctccttcac cactcatgac atatttgcta atgctctcat tcatcatctg atagccaatt 1963981 tctcgtgatt ccgccatttt ttcatcagcc atcagcttgt cccacaaggg gacgactgtc 1964041 agcagcacaa acagccacag gcttagcgca gacattgttt ctattgtaga aaaaccttta 1964101 ttttctctcc acattgactc tcccgctccc tagataaact gttatgtcat aaacggcatg 1964161 gccttttact cgtatttttc cgcctgcatt cgggtgccct ttctcattaa attccaaacg 1964221 gtcttttaat gtcagcagtt ctatagaaag tcccgttgca tacggacgtt caataaccgt 1964281 atcaccaatg actaattgat attctttttt atgaaagaga atttttgttc tttgttgacg 1964341 ggaaatagca gtctgctgtg tgagcataat atcatttttc agctgacttg ctgcctgtcg 1964401 gacagctgta ttgtcataag caggaggaag tgtagtgaag acggccacca ggaggataga 1964461 ggcaaggctt aacacaagca aactttctaa aagggtaaac cccttctcct cgtttaattt 1964521 aatgttcaac cttaacttct ccgccggtga tgataatgcg cttaccattt ggacagacag 1964581 catccttttt cacatagccc tctgactgta aatcggcaag gctcggagtt tgtccttcat 1964641 gatcaagctc aaatgcagtc atttgtgcct taaccatgtt ttgtaagcct tcacagccct 1964701 ttttttgaat ggtttgatta tgtttcgtga cgttcggtat cgtaattaaa agcaaaatcg 1964761 aaataataaa gagcacgatt aacatttcaa caagtgtaaa tcctttctca ttcatcagcc 1964821 tcttcctttc acatttgatt catcatctga tacataggca caagcataga taaatacaca 1964881 agtaagatca tcgctgcaac aaatccataa atcattggct gaaggatgcc tgtccatttt 1964941 tgcgctttgt gttccagccg ctgtaatatg aattggctgt atgtgaaaag ctcccgatcc 1965001 aatcggccgc tcagctggcc gtgagatatg acttttgata aatcagtttc ataaaaaagg 1965061 cttccacaaa tagcggattc aattgactca ccggctttta gccgttcaat caattgttca 1965121 gcctcgcagc ggtagaaagg gagaaacgtt tgatgtttaa atgcattaag gctgtcataa 1965181 attgagaggc ctgattttaa aaggctgctt agctgcaaag aaaaaaagta gctgttaaac 1965241 agctttacaa gctttccaac caaaggaatc ctgatacaaa tcagcatttg ccgggcaggt 1965301 gattttttct taaacacaag ccaataataa atcccgatac ctgctgtaaa aagaacaagc 1965361 aaaatgatca caagatcaat atgctgaaaa aaagcaaaaa gcatatcggt tgaacgtgag 1965421 gtttccatat tcatcgattg atagataccg gaaaactgag gaatgatgat ggactgtaac 1965481 atataaaaca tgacagcgac cgtaaagatg aggaaaagcg gatagcgcag cactcttttc 1965541 agctggtctg cctgtgcaat ttttcgttcc agcagctctc cgctctggat cattgaagca 1965601 ggcagttcac catgtgtttc agcaaaataa caaataccta cggcttcctt atgaaatgac 1965661 aaactcttta gtacttgata aaacggagcc ccttccctca aacaagtgac cgaatcagtc 1965721 aagtcagccg cctgcctctt attcatctga agttccatca ggcgtaatcc atccagaagt 1965781 gtatatccgc ccgcagtcat ttcaccgagc ctctttaata acctggcttg atcctttaac 1965841 aaccagactt ttctaatctt tttcatgata aacccaccgg tcatagttgt ttgtcgttaa 1965901 atagccgagc gcaattcctt ttctgataat ttgacgaagc gtttgatatt ggtaatttgc 1965961 atgatttcct tttgcctcct ggatacattg ctgaagattt ttcccgtata gaagctcata 1966021 aacgctagct ctcctagtat ttcgtgactg tcggcaatac actgatgaac atccgttttc 1966081 acaaaacggg caagccaaat caaccaagcg ctgagccgct attgcaatga cagtctgttc 1966141 gatttcattc atattgatac cgaattcaag cagtctgtaa attgcgccct ttgcgtctct 1966201 cgtatgaagg ctcgttagta ccagatgtcc cgtcatcgct gcccgcaccg caatttcagc 1966261 tgtttccgcg tctctgatct cacctaaaat aatcatatcg gggtcatggc gcaaaattgc 1966321 tttcagacct gcggaataag ttacaccggc tttttcattc acctgaacct gaagaacatc 1966381 ttcgtccctt gtttcaacag ggtcctctaa tgtgacaata tttcgattaa agtgtttttt 1966441 tgcatattga acgagagagt ataatgtggt agtcttccct gaaccagtcg gcccggtaaa 1966501 aatgagcatg ccatgggaat gttttaaaaa cgagagtaat gtggctcctg tcttcggaaa 1966561 tagcgacaat ttatcaatcg aagggatatt gtattggggc atcactctga tcacgaggct 1966621 ttcttcatta attgtgggca gcgttgacat tcttaaatga acatttccct ctttcaactt 1966681 taacgtaagc gaaccgtttt gcggctttcg cctttcacct atatccattg ctgaaagaaa 1966741 tttaaaatgt gaaatcagtc ttacgcactc ttcttttttc atgtcccttt ttttcagcaa 1966801 ggcatgatcg acccgaaaat gaatgatagc gtcccgctcc ctcggcacaa tgtgaatatc 1966861 agaagccttt gttagatatg cctcttcaat caagtttttg cttacctttt ctattgaatc 1966921 caatttgatt ccctctcctt tcaacgcata ttgtagaaaa agaagaaaag gtaatcaaac 1966981 agggaaaacg tgattttgtg agatgttata tgctgaaaaa ccaattcttt ctggcaagaa 1967041 aaaagacttt caactgaatg tacccctgtc attataattt tccctataaa taaaaaagca 1967101 gacatggtca ccatgcctgc tagattccat tttcattatg ctgttttcgc ttattgacca 1967161 gtatctttct caacggaaag atcgcctaat gcaacaatac cggtcatttg gtcattttca 1967221 agaatcgata aactgcggat ttaatgctct gtcataagcc ccttgacatc gtatccggtc 1967281 accctgatat gtctggtgaa aaagcggggc acgctgcaca aaatatgaaa catcctatag 1967341 agtccgcctt tttcgaggtt tctttttctt cttccgctcc tgcagcatat ctcccgtcca 1967401 gccttttttt ctcaaataga gatagatcag aactgtagat gtgacaatca ataagaggga 1967461 aaagagatat ccgtatttcc aattcagttc cggcatcact gaaaagttca tcccccataa 1967521 ggcacccaga gctgtaatcg gagtaaaaag cgtcgtgaaa atggtcagcg cttttacaat 1967581 ttcattcccc ctatgtgagg taatgacttc ctctgaatgc agcagattgt taagctcccc 1967641 ttcaaattcg ctgatgtatg taaatcccct gtcaatcttc agttgtgtcc gctgataatc 1967701 ctttttccct tcattttgag gtaaaaaggt ttctttcaac gccatttcaa tttttttagc 1967761 gcttaatatc aaatttttcc aaatcatcag ttcatggcgc aggagatgga cgcggtttaa 1967821 aatgcttttg ctattgtcgt ctttaatttg ccatctgagc tttctcagct tgacttcaaa 1967881 ttcatcaaca ccgattaaat acgcattcat tagttcgccg agaagaatta aaaacccctc 1967941 tatcgcattg tccgctcttt ccatttgccg aacaacttct ttgcctttaa tctctctcaa 1968001 aattgaaaag tcaaagttga ttgtaaaaaa atattgtctg gtgatataaa agtgaaaaac 1968061 agtatggtct ttttcttcac caagcccctg atcataaaca atcgacccaa atactgcttc 1968121 attttccgtt tcagttgtat ctactcgcaa aaaattaacg tgatggttat tttcaaacca 1968181 cttttcacac tgaggccagt gagaaaaatg gattagatct cttgccttac ttctttcttg 1968241 aggccccatt tggtaccaaa accaatcctt tcccgtatgt gccttcatgt caagctcctc 1968301 caaacttttg ttctttattc tttaattgcc caataaccgc gtcactaaac cagtctgccg 1968361 cttcaacaca tgttttatga gcattttcag gtggtatgga atgtagaaag acatcggaaa 1968421 agggaggtgc atgccttcct tggagaaggc agttgttttg gaatttatca atttactagc 1968481 agtcgctatt ctcattttgt taacaggatt tttcgttgcc gtagaatttt caatcgtaaa 1968541 agtgcggcga tccaaaattg atcagcttgt cgcaaaagga aagaaaggtg ctaaagcggc 1968601 aaagcatgtc atcactcacc ttgatgaata tttatcagcc tgtcagctgg gcatcacagt 1968661 cgcagcttta ggactgggat ggcttgggga accgactgtg caaactctgc ttcgaccgct 1968721 ttttcataaa gcaggcttaa atgaatcgct tacccacctg ctttcactcg tcatcgcatt 1968781 tttagtggtt acgtatttaa atgtcgttat tggggagctg gcgccaaaga gtttcgccat 1968841 tcaaaaagca gaaagcatta ccttgttgtt cgctaaaccg cttatttggt tttataagat 1968901 catgtttcca ttcatttggc tgttgaacca ctctgcccga ttgattacag gagtgtttgg 1968961 gctgaagccg gcatcagagc atgagctggc ttatacagag gaagaacttc gggtcctatt 1969021 ggctgaaagc tataaaagcg gcgagatcag aaaaagtgaa ttaaagtaca tgaataatat 1969081 cttcaccttt gataaacgaa tggcaaagga aattatggtg ccgcgaaatg aaatggttag 1969141 tttgtcacta gatgaagact ccatttcaaa tcttcaggaa acagtcaagc aaacaaaata 1969201 tacacggtac ccggttgtaa gagaggataa agataacgtc attggcgtga ttaatatgaa 1969261 agaagtgctg ttttccatgc tgacgaaaga tttttcaatc aagaagcatc aaattgaacc 1969321 tttcgtacag cccgttatcc atgtaattga gacgattcct atttataaac tattgctgaa 1969381 aatgcaaaag gaacgcactc atatggcgat cctcatagat gaatatggcg ggacgtccgg 1969441 tttggtcact gtcgaggata ttatcgaaga aattgtagga gaaatccgtg atgaatttga 1969501 tgcggatgaa gtgcctcata tccgcgaact tggaaaggat cattacttgt taaatgcaaa 1969561 attattaatc agcgatgtta acagcctgct tggaaccgat ttatcagagg ctgaagtaga 1969621 caccttgggc ggctggtttt tgacacaaaa catagacgct gagcctgaaa gtgccataga 1969681 atatgatggc tactctttta aggtaaaaga catcaacagc catcacattt tatttataga 1969741 agttaaaaaa gctgaatagc ccgtgaaagg ctgttcagct gctatctttc aagataaaca 1969801 tggcaaaggc atcaacactc ttttatttta aaccctttat tggccagggc tttagcaaga 1969861 ctttgctctg ttttcacatt cgaaaaatcc agacccagct tcacgacagt ttgggcaatt 1969921 tccggcctga ttcctgaaat aatagtctca atgccgagca atttggtgct gtcaatcact 1969981 ttaaaaattt gataggctac catggtatca acgataggaa cgcccgaaat atctaaaaat 1970041 aaatacgaga gctttaacgc tgagcactgc tccagcacag actccaaaat cgtcctcgct 1970101 ctgtgcgtat caatttcacc gacaagcgga agaatcccaa ttccatcagt aatcggcata 1970161 atcggcgcac tcaattcatt aatcatttct ttttgcgcgt ttaattgtat catggtcacc 1970221 tggtgatatt cttccgtaaa cacttcgatg atctcatcaa tgttttgatt caagatccgg 1970281 ctccactcat aaaattcctg aatgctgatg tcttgagaag aagcttcgct gaatttatga 1970341 atccattcaa acatgatgtg cctgaaagtg ttaaactggc cgacactttg tgtaaccgtc 1970401 acttcatgaa cggcacggtc tctggcgcat tgaagagacc accggttgag ctcatcctct 1970461 acgtcttctt ttctaaggga ttttgctacg atggtcacca ataattcatg ctggtctttt 1970521 aacttttgtt ctagtttttg ctgatctttc gctgaataca gccagctgcc gtttgacgta 1970581 caaacttcca gccattgttg cgtaatatct tttttgtgct ctgttaagtg ctgatcaaga 1970641 gctatcatct taatgagtta cctcctgttt ttgaaaaatg tacgctatat atgtataacg 1970701 cgtctgcctt tacacatact atgtttagat tcaatgggct atagccaagc ggtaaggcaa 1970761 tggactttga ctccgtgatc gttggttcga atccagctag cccagtttct gaacaggtga 1970821 aaaaccgaag ataagctgat tcgtataaat cagcggatct tcggtttttc atcatgcaga 1970881 ttgatgaacc gttttcttct tcgataactt caacagttct cccgggttat aaccaatcac 1970941 cagctttttg ttgtctacta gaatcgggcg tcgcaaaagc ttcggcttct cgattaaaag 1971001 ttccagcacc tcatttaccg tcatttcttc aatgtttaaa tttaaatttt tgaaagtctg 1971061 gcttcttgtc gccaaaattt catcaattcc ttctgtcgtt aacgataaaa tgtactttaa 1971121 ttcttctctt gtcggggttt ctctgaataa gtgccgttcg ttaaattcaa tttgatgtgc 1971181 tttaagccaa tgttttgttt ttcggcatga cgtgcagctt ggatatgagt aaaaagttaa 1971241 ttgttgttcc attcgttttt tcctcctcag ttaaccatct ctttgtagaa taactacccg 1971301 gatcattttt catttaaacc atttacagaa cttttttcgg attatttttt aaaaaacatt 1971361 catacaatag aaaacacaat caaagggaca aattccattt gtatattaat aatgaaaatg 1971421 tttacatttc taggtgtgat ctattataat aacagtcaga gggactctcg ggaggggata 1971481 aaaatgaatc gcatgttccg ggtgttagga ttttggacgg gaatttttgc agtcatgttt 1971541 tatttaggtg atatgaaaga tgcttccctt ttattttttg gacagacgat cttatttgtg 1971601 tttctatcgt atttgaactt aaccgaacgc atgtatattt atatttttgg cgcttattta 1971661 acaattttct tcgccggctt tacatattac tcaattttta ttatggtgcc cggcggcgga 1971721 ggccattaaa tgcagaaaga gacaaacctt atcggtttgt ctcttttttt acaatgaaaa 1971781 cccatttaaa aacggatttt gatcctgctc agtcagtacg tctgtttcag gtccatggcc 1971841 gcttaacacc agcgtgtgtt ccggaagcgt aagcagtttt tcatgaatgg acgtcagcag 1971901 cgtctcttga ttgccgccta ttaaatccgt acgtcctata ccgccttgga acaagacatc 1971961 tccggaaatg accaagtctg catctttcac gtagtaagac acactgcctg gtgaatgtcc 1972021 cggcgtaaat aatgtttcca aatgaaacgg cccgatattc aactcaccgt cgccttcaat 1972081 tagatgatct gcaggcttag ctgtgacttc tatccctcgc agcatgccgg agccgtttaa 1972141 agaagcgtcc gcaagccaat ttttttcatt ttgatgcagg taaacaggga tatcccattt 1972201 ttctctcact tcatcaagcg ccccaatatg gtcaaaatgg gcatgtgtaa gcaaaatggc 1972261 taaaggcgtc agcccttttt cttttatgta ttgattgatt ttatgtccct cgccgcccgg 1972321 atcaaaaatc agacattgat catcactgat gagaaaatat gcgttcgctt gaatcggccc 1972381 tactggcatt cgtctccatt tcactattat cacctctttc ttttttatgc tcttattatg 1972441 agggtttttg aaaaaagatt caaacaatcg caatgaaaac gctatcgaca aacctataaa 1972501 aaacaggtag aataaaactg gaaagaattg caggtttttc aatgtaaagg gggctgtgtt 1972561 atgttacttg tcgtgatttt cggccttgtc gctcttttcg ctttatgggg agtcttgcgt 1972621 tctgttagaa ataaaaatat actcgggttt ttattagccg gtgccacctt atttgtcttt 1972681 ggatggttta ccgtgatgac cgtaataaac agcgggtatc caaccgcaca ttaaaacctg 1972741 tatccgatcg gatacaggtt tatttttatg gctgtaaatg tttattgaca ctttctattt 1972801 tgctctcaag cgtcgttttt ttgtcacgcc tgtcatcgat acggatattc gttgccactc 1972861 tgtgcaatcc tttttgaaat ggcgcttcgt gaattgcctg aataactgca aaaaggtcac 1972921 tgagttctcc ctcgatcagc gtattcatcg gtgtcagctg atatttgatt ttcccttctg 1972981 cttgatatcc ttctaatatc ttttgcacat cggctacgta agcactgaca ctgggtgttt 1973041 ccgtaccgat tgggataatg gttacatctg cgatagccat cgttattcca tctccttttg 1973101 atcaatgatg agttgcttcg tttcatgtga tttcaataaa ataatttgct caaaatgaaa 1973161 gccgtataac gcatatttcc cgttcggaga tatttgaatc ggctccattt cccgcagaga 1973221 cacaagatct tttgtctctc ccgatgctac attgattgct gcgagcttat atgcatcgcc 1973281 gctttgtttg aatgtataaa acaggcctcc tgcttcatca tagtcatact ccattggagc 1973341 caaacttgta tatttcgctt ggagcggcca tttcgctgta acaggtgatg ttgattgcgg 1973401 cgttttaaac tgatacgtcc cttttcctcc ggaagctgat ttgacagtaa aactcatttg 1973461 atggaaagaa tcgaagaata gaacgttatc ctcaagcttc tgttccgtct tagaagctgt 1973521 atcgaacgta tataaaggcc ctgttttatc gtctctaccc tcttttacat aatcaaatgt 1973581 atttttggat gtccaatgaa tgaacggaac ctgtactggg cttaagaaag attcgtcttt 1973641 tttagcattc acctgatatg tatggaaatc ccagttttca ttgaattccg tcaccatcat 1973701 ttgataagga tcatactgat tccaagcagc ttcaagctca tacgtttcgt aatctttttc 1973761 gtaaagcgtc tctccttctg cattaagcaa aaccactgcc gtcttttggc tatgtgtgat 1973821 ttgcagcaga atcatctgct ccctcgcatt gatttgaaca tcaacgattt gaccatccgt 1973881 ttgatagagc tttttcgctt tgcctgtaaa gatgcggtac gcaaaaagct ctgttttcgt 1973941 cggattagac gcagtatata atattgtgct gttattcagc cagccttccg ccccatccgc 1974001 tttttccgcg gaaagcggta tgatgtcttt tttctcatct tttgccgccg atgcctgttt 1974061 ttgctgctga tgagatggtt cgcatgccga taaactaaac agcaataccg ccagcagaat 1974121 aaaacaaact gatctcatca gcattcccct ccgatcatct ttattctctc atatttgctt 1974181 cggcagaaaa aagaaaaagt ttcagttact catgaaaaaa taacgccctc cacaagatac 1974241 cgcttgtggc gttatatatg tgtgaaaact gctgaaacgg caaaggattt tggccttttc 1974301 caagttccac cgtataccct tccttaaaat aatggtgaat aaaccaatca cgaaatccag 1974361 catagctgtc tatatccctt actcccttat aaatgttccc gcttaactcc tcaaactcct 1974421 ttatgacggc agcagattcc tcaggctcaa ggcctttata gccccaataa atttcttctc 1974481 cttgagtatg aagagccagc agtctgtcag gcggattctc cgtgatcagc cggtacatcg 1974541 caatagattc cggctccgta agcggagaga ttcccggaaa atcgcggtag ctgggtgctg 1974601 tcggttttcg gtatttttca atttcccata atgatggaaa ttgtttattt aaatcaaccc 1974661 cgtttatatt cgccttccat tcattaaaat ttggacgatg ttcatttagc ctttcgagtt 1974721 catctcttct ggctcccatg acttctgatc cgtttaaaac aagatcaacg ccatccggat 1974781 tgacaagagg aacgagggat aaggatgtgc tgttaaacag ctttatggga gaaaagccaa 1974841 agaaaggcga attgcagcat aatgacatac agtattcctt aaaccatttt agcaggacag 1974901 acgttgtaat ccactcattc gcatgaaatg acgcgttcat atggaccttt tttacggcat 1974961 gctccccacc agccttcagc tcccagatag gcctgccgag tacagaacgg ccaatttccc 1975021 ggcatgagac aaacggaaaa acatcaataa tcttctttat ttccttttca acagctgaat 1975081 catcatagat tttctcttgc tcaatccagc tatctgaaag tttcagctgc cgaggctgta 1975141 aaaagcgctt tatgtcctga atggtttgaa gctctttgcc gctatgctcc tctatcacat 1975201 aaccagggca atacaattga tgtttttgtg cggagcgatt tgcactttta agcaattcct 1975261 cgtctatctt cagttctttc gccacattgg ccaaattgtt cttgatctca ggtttcaccg 1975321 taataaacgc catcatcatc cccctttttt gttactatat gacagcgtat ttaaaaaaag 1975381 aaagcctccc gctcacttcg atgcgggaga cattgtgatt atgatgcctg atcaagcatt 1975441 tgtttttctt tccgctttga cgaattgtcc agccttttct ggtcataaaa tcgcaacaaa 1975501 tccccataaa tgatttcatc agaaagtgat agctcctgtt ttgctttatc agcaaatgct 1975561 tcacattgtt ttgtctcttc taacggtttt cccgtctctt tgtcataaca cgcaccgtct 1975621 gtataaacaa cctgatctgt gataaagctc ccgtcccgga gcaccgtgaa gtccagtttt 1975681 tcgtctgaaa gcagatcgtt gccgaattga atttgatctt tcgtatcaat ccctaaaaga 1975741 ttcatcagcg tcggcctgat atcaatctgc ccgcctactg tttcaatggt ttgcggcttt 1975801 ttatcagtaa tacccggaat atgaatgacc agcggcactt tttggagctg tacctcttca 1975861 aatggggtta tttcttttcc taaaaactgc cccatcgctt cattatggtt ttctgatata 1975921 ccataatggt caccatataa tacaataaca gagttgtcgt ataacccgtc ttccttcagc 1975981 ttttcgataa accgtttcag cgcctcatcc tgataacgca ctgtcggaaa atatttattt 1976041 agcgtctggc tgtttgaatc atattcatca atcaattgat cctcttcatc aagatcaaac 1976101 gggaagtggt tcgtcagtgt aatcagcctc gagtaaaacg gctgaggcag atttttcatc 1976161 agctctgagg actgctcaaa aaattcttta tccttaagtc cccagccgac tgaattttcg 1976221 tcagttacat catacgagtt aatatcaaaa aacgaatcat atccaaatga gtcgtacatt 1976281 aaatcacgat tccaaaagct cttattatta gcgtggagca ccgctgaata gtatccgctg 1976341 tttttcaaaa tttcaggagc ggccatatat tgattgcccg cattcgtaaa aaatacggca 1976401 cctcgtccaa gcggatacag tgaattgtcc acgataaatt cagaatccga ggttttcccc 1976461 tggcctgttt ggtggtaaac attattaaag ttgtagctct gttttataaa gtcattcaga 1976521 aaaggcgtga tttcttctcc attcaatttt tcattaatca cgaagctttg cgtcgactct 1976581 aaggatacga gaatgacgtt ccttcctttt gcagcgccga ataagcgttt gttggcatcc 1976641 ttcgcattag cggttacgta gttttcaatc tccgtcaggc tgttgctgtc tgccaacgct 1976701 ctctgtgcgg attgctttga ctgaagaacg ccatcgtaaa tatgaaaatt aaacaggcta 1976761 atgtttttaa caagcatttc tctgtcaaat gagcgtgtca atagctgagg tctttccgcc 1976821 tcagacaagc ccaggttgaa gaaataaaca gaagcaacga acaaaaaata agccgcccgt 1976881 tcatttttcg ttgagggaat gtccgattga aaagcttttt gccggatgtg aagccatatt 1976941 aaaaccgcaa tatctacagc taataggagg tctgtcggct caagaagtgt tccgatgctg 1977001 cttccgagat cacccatatt gctcgtttga aaaagaacag ggattgttaa gaaatcattg 1977061 taaaaacggt aaaaaaccat atttgccagc aatacaaacg tgacaagaca gctcatcgcg 1977121 ataatgtagc gatttctgtt tttgcctttt aaaaacaggc tgaggccaaa aataagcaac 1977181 aaaaaactca atgggttgat aaacagaata aattcctgtg ttagattgtc gattttaata 1977241 tgaaaactgg ttttgtaaac agcatacgtt ttcagccaca tcaataaaat ggcaatcagc 1977301 ataaatgaaa tcttcgaaaa aaacgttttt cgcatttcaa cctcctatgc agcacgctca 1977361 aaaaaatcag tctattccca acattctcat taacacatca aattaaatct taacctgagc 1977421 acaacaaaaa atcaatttca tttacacaat tttaacaatt ttgatgtttc agccattcat 1977481 ttttagcgat ccaagcgcct ccgataacgc cggcatcatt tccaagtgct gcgattgaaa 1977541 tatcagcagc ttgggctgcc cgcggaaacg cgcatttgcg gaatgttttc tcgacttttg 1977601 atctcagcag ttctccggct ctcgatacgc cgccgccaag aacgattttg gatggattaa 1977661 gcgagcttgc caaatttccg agcaccaaac caagatgctt ggctacataa tcaaccacct 1977721 caagggcaat ttcatcattt tcacccgccg cttcaaacac atctcgcgct gacaattgtt 1977781 cggttgcttt taaacgtgtc gtctttttag catttgctat tttttctttt gcaattctta 1977841 caattccggt tgctgacgca attgtttcga tacagcccgt tttgccgcag ttgcagggcg 1977901 ctccgccttc agggatgctg caaatatggc cgatttctcc gccggcgcca tttataccat 1977961 gtacaatttc accatttgca atgatgccgc cgccaactcc tgtgccaagc gtcacgagaa 1978021 tgacgtcttt tgcgccatca cccgctccct tccacatttc cccgagcgca gcaatattcg 1978081 cgtcattttc tataacagct gggatgccgg tttctgtctc cagatggttt ttcaaagcat 1978141 aatttttcca ccctagattt actgtttcat aaaccactcc tgccgccata tctacagggc 1978201 ctggtgcacc cattccgatg tatttgatga tgtgcttcgg tttttgcagc tcatccagct 1978261 tgctgtcgat tgtttttgca attgtgacag taatcgtgtc gccggtttta tctgtcggaa 1978321 cttcccactt atgctgaatt tcgccatatt gattaataaa agcgagttta atcgtcgttc 1978381 ctcccaggtc aatgcccgca aaccatatct cgtccatttt tatcacctta gcctttataa 1978441 aaatctcttc cgttttttgt ttgttccaat tcttttcgaa ggacagctgc cgctctggcc 1978501 cactgctcct tttcaatcat gtggttcatg tataattcct ttaattcatc cagcataaac 1978561 tcaatttcaa gctctctgtc tccaaaataa acaatgtggc caaacgtttt taacagctgc 1978621 tgcacatcat aaaatgtatt cattttcctc accatttctt gaacttaact atcataagcg 1978681 tattcataag gaagcggtca gtcaagaaga aaacgctgac aaaaaagcca gcttcctttc 1978741 catattccac ctctatgatt ctttattgtt ttcaatttgc cgctgcagct ccttgtagcg 1978801 ctgctccttc ggcttcagtt tcacagccgt ctggatggcc ttttctgctt gtgcaagctc 1978861 atttttttcc gcatacaata acgctaaatt gtaataggaa gcatggtctt taggttcttt 1978921 tttcactgct cgttccaaaa gggaaaccgc ctgatcatat tcgccgattt gaatatcaga 1978981 aacagcaaga attttcaaaa gatcggcaga ggcatctttt tgcgctgctt ctccgttcag 1979041 caattctgtt acttcttcat actttccttc ctgatacagc tcgcttgcct gctgaatcag 1979101 cgctgactcc tggtgtgaag gcgaatgcaa tccgtaatat aaaaatccaa cagccaaagc 1979161 aatcagcaaa accgctgaca acaatctttt tccaaaggct ccggctttag gcaaccccag 1979221 tgctgctgca gcgaaaaagc cgccaatcaa gccgccgata tgtcctgaat tatcaatatt 1979281 cgaaaccgca aaaccaaagc ccagattgat gataataatg acaataatat tggttcctat 1979341 agttcttaaa aacatttttc gattagacaa agcaacatac agtaatgcac ctaagcatcc 1979401 gaatatggct cctgatgccc ctgccgaagg atacgggctg aacacaaaac tcgcaatcga 1979461 acccgtaatg ccagcagcca gataaatcag caaaaatctc cccgatccat acatccgctc 1979521 aaccgctgta ccaaccgacc ataaagccag cgtattaaaa gctaaatgcg ctatgccgat 1979581 gtgaagcacg atcggtgtca gaagccgcca ccattctcct tgtgcaatca ggctgttttc 1979641 ttttgctcca aaagccacca gtgtctccgt attagtgctg cctccgttta tttcgagcaa 1979701 gaaaaacatc aggatctgaa gcgcaataaa taaatatgta aaagtcggtt ttccgttttg 1979761 aaaaaccgcc gcttcagttt ttctctgttc ttcttgtttc agcactagcg aaaggaagcg 1979821 ttctcgcgcc atttgcgcgt tttcaaacga agcgtgttcc tctgaacaat cttctgtacg 1979881 aaatgatgga aaaaccgctt gaagatcatc tcgaagcatc gttcctctaa cgatcgccgg 1979941 ctcaactgac acagttccct tctcaaaagt tttttttgca atctcttccc agtcatcaac 1980001 tggggcttcc gttgaaaaaa acacgttcag cagcttcatc cttcgtctgc ccaattgatg 1980061 tctgactcgt tctactcgtt cggcctgctc ttcgatgtct ctaaccattt cttgacggaa 1980121 atcaagatcg tgcttataaa gacgaactag atcatgagag gacttgtccg gcgcttccag 1980181 ccatatttca tctgactcac cggcttgtat gacgccatac ccgctattca ccaggtgcgc 1980241 cgcaattttc caatatgtat actccagcaa aaacatgttt accgctccaa tagttttttt 1980301 tcattataac agctggcgct ccgaaacgcc tactgaaagc aaaaaatccc gtttttcacg 1980361 ggattttaga aagcttgctg tataaactta ttgcggataa atggaattct taaaaacaaa 1980421 tggataaaag accgcctgat tcctggctgg ctgagtacag tattcataag acggtagcga 1980481 ttttgataaa acatgacggc agaaaccgcg aaaatggcat atatcaaaag ttttttcatg 1980541 atatccctcc tgccaatagg gtttgttatt ctaccttatt tattctcgaa taagggacag 1980601 gaaagttatg aaaaacaaga aataatccga tcctctgtta tcagcttatg taccgggatg 1980661 tcatgcggca gacggggtac gtgcgcaaac aactggcact ccaaaagcaa agagactgtc 1980721 ttcccttcat attcacttaa atagcgatca taatagccgc ctccaaagcc gaccctaaac 1980781 ccgttaacat caaaacaaac acccggaacg atcatcaagt caatttgtga tgggtttact 1980841 tcttttgttt tttcaattac cggctcgagc agtccggcgt acacggtttc gagctgatca 1980901 tcagtctgat atgtgcgaaa ttgcattttc ttcgtgtccg gatggcattt tgggatgcaa 1980961 acttgtttcc cttcttccca agcctgctca atgacaggac gcgtcggtat ctctaatcct 1981021 ctggaaatag tgacggcaat ggtgccggca ttttgccact ccggcagaga aaacaagtac 1981081 ttatacatac gttccgtttt ttgaagaata tcttcatttg ataaagcaga cagtgcctcc 1981141 agcgtctttt ttcttaattg tgatttcatc tctcatcccc ctcggaatag aaaaaaagcc 1981201 agaacctttt tcaaagctct ggcttttttc ttacacctca aacagcaaag ctgttatttt 1981261 gtttcacggt gtaacgtaga ttttttatca cgtgggcaat attttttaaa ttcaacgcgg 1981321 tctggattgt tgcgtttgtt ctttttagaa atatagttac gctcaccaca ttcagtgcaa 1981381 gccaaagtaa tattaacgcg cattattttc cctccaaact aaaatcattt acttattcag 1981441 acttatatat aataccacta taatggacgg aatgctaggc tgtttttcaa tgaattgctg 1981501 aattattgaa gatacgctca taaagctgca aatatgatga cataatgagt cgggggtggt 1981561 ggagcttgaa cacttgttgt ctgccagctt cttttatccg gcgggctttt tcccggtctt 1981621 ttaaaaaact gtccagcaga tcagcagctt cctgtacgag cgtaaaatca gcgatgattg 1981681 ccgttttgtc atgaaccgca taatcacaaa aaccacctga ctgagaaacg acagtcagca 1981741 caccttgttc catgctttct tgcgcggcaa gcccaaacgg ttcataagaa ctagggaaaa 1981801 cagccatttc acagtgagac agtaacgttc tgatatcttt cctatttaga aacggcagaa 1981861 acatgacgcg atccttcagg ttatatgccg cagccaattt ctcatagcag gacagagacg 1981921 gcccctcccc agccagcact agatagaggt caggctgacg ctgcttcaag atggcaaaca 1981981 cctttaacag ctgcgataat cctttttccg gaacaaacct tccatatgaa aagaggaatc 1982041 ttctattcat gcttctcggg attttcccct tctcttcctc catagatgca gggcttggga 1982101 taacggttat tttcttatgt gccgccttat caagagaccg cttcataaat gtgcttaata 1982161 cgatcaatgc atcagcggat tctataagga gccgttcggt catgagcctg tatgggtgtg 1982221 gggcttctcg gcacaccttc ttcctttcgc tttcaagacc gtggattgtc gcagcaagcg 1982281 gaaggccaag ccgttgtttc aaatactggg cggcaggggc agttgtgtca tcatgggcat 1982341 gaatcagatc aaagcgttta ttgtgtgata acacatggcg aaccattgta aagttagcat 1982401 cagctatgta atcttcaaac ttcgcatacg aaaacagctg cccgctcgga gtaaaaaccg 1982461 taatgttgat atgagggttt aaataggaaa tgaggcggtt taaatggaca ccgagcccgc 1982521 ttttcggctc atcgggatgt tcgggtgaaa gcatgagaat gttcaccgtt ctttttcccc 1982581 tctcccataa caggtgtatg cagaaaattg cgcctcccac ctggtgtgcg cttcttcaat 1982641 ctgaaaactg tttatatgac gaatcccatt ttcatcaaga tagatgtcgt ctgtaccggc 1982701 aagcttgaga gagacattca ttgaattcac aattctgtat tcagcccgat atacagcatc 1982761 accagccgcc tgtctaatcg tccattctcc tttatcatac gttgtgcgtt ttgtcctgac 1982821 agcttcaatg tcttttcttt tgatgacaat gcgcaattct tttatcatat cctgcgtttt 1982881 ttcgaaaagg accgcttcag ccagccgcat tgtttcttct gagatttccc agcttacggt 1982941 caaggtgtga gcgttttgaa tgattatgtc gaatgtgtcc ctaaaaaagg aaagcttatg 1983001 tcgtatatta tagggaaatg ggtgtttatc catggactcc taacattctc ctttccaatc 1983061 gttcacttcg tgttcctatt aaaccattac atgaagaaga agcgaagaaa gatttctcga 1983121 caaaatctcg tttttttcgc gaattccttt agaaactatt ggttttatgg tataaaaaag 1983181 aaggataaaa aaagaataga aggtgatgaa acgtggaaat tgctattatt gcgttgttta 1983241 tcgtcagtat agcgctaatt gcattctcat attctcaaag agacccgatg aaagatgtag 1983301 aacaggagct cgaaacactg cagctttctg cgatgcagga aatttacaag ctcaaaaaga 1983361 aaatgacagt gcttgaggaa gaattactgg aaacaaacct tgtcattcgc aaatcaaagc 1983421 agaacgacat caatcaaaaa atcgctaaac aaatactttc taaatataat aacggtatgt 1983481 cagctgaagc gattgctaaa gctgaacatg tatcagtgga agacgtgaat acgattatca 1983541 aagataatga gaaggtgctc gtatgacaaa acggggcatt caggcatttg ctggcggcat 1983601 cattttagcg acagccgttc ttgcagctgt tttttatctg actgacgaag accaggccgc 1983661 tgctgtaaaa gataataaaa cagtaaccga acaagacgtg aacaattatc ttgattctaa 1983721 aaaattggtt tctgtcaacc gtgatgaata tcaaaaactt ctcgattcaa aagagaaatc 1983781 cttaaacaat gacagcggct cagacacgaa atcagacaaa gtcaaaacct acaagctcac 1983841 cattaaagac ggcatgagca cggcggatgt atctgctatt cttgaaaaag agggcattat 1983901 ctcttcggct caagacttta atgactatgt cattgatgcc ggctatcaca aagaaattcg 1983961 tgccggcgag tttaaagtaa aatcagacat gagtttcaaa aagatcgtaa aaacgttaac 1984021 acgataaaaa aacaggctga ctcagcctgt ttttttcatc caaactttcc tgaaatgtaa 1984081 tcgagcgttc tttggtcctt cgggttagag aacattttat tcgtattgtc gcattcaaca 1984141 agctcgccca tgtagaaaaa ggcggtttga tcagaaaccc ttgctgcctg ctgcatgtta 1984201 tgcgtgacaa tgacaattgt atatttatct ttcagctcta gaatgagttc ttcaattttt 1984261 ctcgttgaga ttggatctag tgcagatgtc ggttcatcca tcagcaaaat atcaggattg 1984321 gtcgcaagtg ctctggcgat gcaaagacgc tgctgctggc cccctgacag cgaaagagcg 1984381 gacgtatgca atcgatcctt cacctcatcc cataacgcca cgtcttttaa tgacttttcc 1984441 acaatttcct gaagcttctt cttatttttg gtgccgtgga ctctcggtcc gtaagccaca 1984501 ttatcaaaaa tagattgcgg aaacggattc cctttttgga ataccatgcc gatatttttt 1984561 cgcaaatcca cgatgtccac tttatccttt aaaatgttgc tgccattata gttcagctca 1984621 cctgcaagct ttacattcgg cgtcatttga atcattaaat tcaatgtctt gataaaggtc 1984681 gatttcccgc atccggatgg tccgataatc gccgtaacct cattttcata aatgctcaaa 1984741 ttgatatttt ttaaagcatg atgctgccca taccataagt tcattccatt gacttgatat 1984801 acttcctgtt tcattacagc ttcggtagca atactcattg ccgccctcct atccgaattt 1984861 cccgttaata taatcctctg tcttttgctt tttcggactc gtgaaaatct gttcggtctg 1984921 tccgtattct acaagctcgc cgtttaaaaa gaatgccgtc cggtcagaaa cccgcagagc 1984981 ctgctgcata ttgtgcgtga caataataat tgagtattct cttttcaatc ctgtaattaa 1985041 ttcctctatt tttgcatttg aaatcggatc aagcgctgaa gctggttcat caagcagaag 1985101 aacagccggc ttcatcgcaa gcgttctcgc gatgcataaa cgctgctgct ggccgccgga 1985161 taacgagagt gcggatgaat gtaaacgatc cttcacctca tcccagagcg ctgcttttgt 1985221 taaactttct tccacaattt catctaaaac agctttattc cgctctccgg catatttcaa 1985281 tgcatgtgtg atattcgcat agatcgattt cggaaatgga tttggttttt ggaaaaccat 1985341 tccgatttct cttctcaagc tgacaacgtt aatattgccg cccaatatat ttaatccctc 1985401 ataaaggatt tcaccttccg ctcttgcaga tggaattaaa tcgttcattc ggttaatatt 1985461 tctcaaaaaa gtagattttc cgcatcccga cggcccaatt aaagcagtca ccgcattttt 1985521 ttcaatatcc atgtttacat gatgaacggc ttgtttattt ccgtaataaa tggacagatc 1985581 tttgacctca agcacgtggt tctgcttcgg aacaataaca gctcgctcag gtttttcttt 1985641 taccatttgt tcagacatgt ttttcgcctc tttccgttct aatttgccgt aagctttttg 1985701 tagatcatcg tgccaagcca tctcgccgcg agattaaaca caagaacaga aatcaccagc 1985761 acggcagaac caccgttggc aatcgcttca gcatccggaa tcattccttg tgtattgacg 1985821 ttccaaatgt ggaccgcaag tgtttcagcg ggcctgaaaa tattaagcgg tgatgtttcc 1985881 gaaaacgggt tccactccgt aaaattaaga cgcggtgttg tcaggcctgc cgtaaataat 1985941 aatgcggccg cttccccgaa cacccttcct gacgctaaaa ttgctcctgt gatgatagaa 1986001 ggaatcgcac ttggaattaa aactgttttt acggtatgcc agcgtgatac acctaaagcg 1986061 agagaggctt ccttcagatc tttagggact gaacggatcg cgtcttctgt cacacgcacc 1986121 atgacaggaa ggttaaaaac agttaacgca agcgctccgc ctatgatcgt ataaccccag 1986181 cctgttaagt tgacaaacat caataatcca aacatcccaa tgacaataga cggaagagat 1986241 gaaagcacct ctatacatgt tctaatgaag tcagttactt tgttattagg cgcgtattca 1986301 gccatgaaga ctccgccgcc cacaccgagc gggattgtaa tcagcattgt aataaacaaa 1986361 atataaaagg agttaaacag ctgatctcgt atgcctcctc cagctgcaat ggcgctcgac 1986421 tttgttgtaa taaattgaaa actgagctga gaaacaccgt ttataataat ataggaaaac 1986481 aaacctacta aaatggcagc gataatggct gcacacaaac caaacattcc ggtcgccagt 1986541 ttatctgtta ttttgcggtt cattacactt tcctcctaga tgacaagtag cgaataagca 1986601 ggatgaacaa gaatgacatc accagaagca caagccccat tgaccacagc gtattgtttt 1986661 caacacttcc gtatgtggtg tggcccatat tcagcgtgat gatcgttgtc agcgttcccg 1986721 cagtgtcaaa cgggctttcc ggcaatactc ttgtatttcc aatgaccatc tgaacagcca 1986781 aagcttcacc gaacgcccga gccatgccta acacaacagc tgtcatcaat gttggaaaag 1986841 ctgcaggcac aagtactttt ctgatcgtct gccatcttgt ggcaccaagc gcgtaagaac 1986901 cctctcgtaa actcttcgga agagaagcca ttgcatcagc agaaatcgat gtgatcgtcg 1986961 gcagaatcat gacggaaagg acaatcgttc ccgccaataa actgtgccct gttccgctcg 1987021 atttgaactg ggcgataaac ggcaccaata ctgtaagacc tatgaatcca taaacaacag 1987081 atggaatacc gactaaaagc tcaatcaccg gctgcagcac tttctttccc caattcgggg 1987141 caatctctgt cataaaaatc gcacctgcaa tgccaagcgg cgcagcgatt agagcagaaa 1987201 gaatcgttac tgcaaatgag ccaaaaataa atggcagcac tccgtatttc ggatcactat 1987261 ctgtaggatt ccaatttaag ctcgttaaga attcaattgg gcttacacca tttacaagaa 1987321 aagattgcag ccccttaacg ccgaggaaaa tggtaatcgc aacagatgcc gcaatcataa 1987381 tcagtgcaca agctgtgact atcattcttc cccgaacttc atccaattgc cgattttgcc 1987441 tagagctgat taagcgctcg ctcacagaca tattttctct attgtttatc attgttttac 1987501 actcctatga atgtgttaag aggagaaacg gttgtccccg cactcctctt tttattaaga 1987561 tcagctttgc ttcccgttgg catcacgtgt cactttcata tcagtaaccg gaatgtagcc 1987621 ttggtcagta acaatgcttt tttgaatgtc ttcactcttt agataatcaa gaaattcttt 1987681 agctaaacct gtcgcttcac cttttgtata agaatgttga taagcccaga tcggatactc 1987741 gccagttgct acatttttcg cttcaggttt aacaccgtca atagatagag cagttacttt 1987801 gtcatctgtt aaatatgaga atgcaagata tccaatcgct cccggagtat cagcaatgat 1987861 ctttttcacc gtgttggagg aatcttcagt aatgccttct gcaggctccg ctccgtcaag 1987921 cgcatatttc acaaatgtag cacgtgtgcc ggaagaatca gggcggttta caagtgtaat 1987981 cttttggtct ttgccgccga gctctttcca gtttttgatt ttgccagtga agattttttt 1988041 caattcatct tttgaaatat cctttacacc agcatcaggg tttacagctg ctgccatacc 1988101 aactacagcg acttgatgat cgacaagcgc ttttgcatcg atgccttctt tttcttcagc 1988161 aaaaacgtct gaattcccga tctgaacagc tccttcagag acttgagaaa gccctgttcc 1988221 agaaccgcca gcttgtacct gtatatcagc atcagggttt tcttccataa atttttccgc 1988281 ggctgcaagt actagtggct gcattgccga tgaaccagaa atggttaaag aacctgatgc 1988341 cttttcttct ccttttgcag aatcgctatt cgatttttta ctttctcctg catttccgca 1988401 tgcagctgca atcatcataa aagcagccat cagaagcata agcaccaatt tgtttttttt 1988461 catttcctga attccccctg cgtataatgt gtaatttgtc ctacacgtat agagtaaagg 1988521 ttctatgtaa aaagggtttg aaccgaatgt taaggttttg taaatcagtg cgtttttttg 1988581 tataaaaaaa acgcccacat catgtgagcg ttttttttta gttatcagaa gacgttgtgt 1988641 tttctgcatt ttcttcaatt ttgtctttat tcttttgctg agtaccttct ttgtcctgct 1988701 tcgatttcag ctcaaaatat ttatccatta cttccctgcc gatttcgttt gtaattgagt 1988761 atctttgatt gtaatcaatg taagtccaag gaactacgac agaaatagca atctcaggat 1988821 tgtcagctgg tgcataagcc acaagcgtcg tattataagt gtctgttcct gtttttgatt 1988881 tatccggtcc gtcgtaaaat gattgggctg ttcctgtttt tgcagctggt ttatacgatg 1988941 ctgaagccag ttgacctgca gctgtccctt tagtggcaac ccgtctaaaa ccggcttgga 1989001 cctcttcaat atagctactc ttcatatcga ctttattcaa tacttcaggc tgaacagaat 1989061 caacgactgc gccgatccct tttttcgcat ttgaatctct gacttccttt acaagctgag 1989121 gcttcatgcg gtagccacca tttgctatgg tggagacata ttgagccaat tccagcggtg 1989181 tataagtatc atactgtcca atggcgaaat caagcaagaa accagataat ctgcttgtac 1989241 ctttatatcc cgtcatttca tttggtagat caattcctgt ttttactcct aatccaaatt 1989301 gactgaaata atttctgaag gtatcaaatg cagaagtatc caaaggcaat gcttggtgag 1989361 gtttatattc acctttacca actgcaattg ctgttttaaa cataaaaacg tttgatgact 1989421 tctctaatgc agtttgaata ccaaccggcc ctaagttttg ccaagatttt ttccctcttt 1989481 tatcctggcc gatatacaat ggttcatcct taaatacagt attcaaatta atcgctccag 1989541 tttgaagacc ggtcaaaacg gttgcacctt ttacagctga tcccatagcg taggatgaag 1989601 tcatggctcc taatgcataa tcatcaaact tataggctcc attttctcgt ttaatctgct 1989661 tccctgccat tgtcagcact tcgccgtttc tagggtccat catgacaacg aatgcacgat 1989721 ccaacaattc ggtactaggt cttgctttag cagctttaag ttttttctca ataatttttt 1989781 ccactgattt ttgcaaatca atatcaattg ttagtacaag atctttcccg gctttgcctt 1989841 cagataccgt ttttgttccc gtgacattgc cttttgaatc tgtgatattt tcgacttttg 1989901 ctttttggcc ctgcagaagg ctttcatatt ggtattccag atagcttttt ccgaccctgt 1989961 catttcggct gtagccaagc gacagataat ggtcgagcaa gttggacggc aatccttcat 1990021 tagagctgga aacacttccg agcactgagc gaagaaggtt tttataagga tattcacgtt 1990081 cccaatcgga cgtgacatca acacctggca gttcgtctaa atgttcactt accactgcca 1990141 tttccttcgc tgatacatct tcgtttttga tatattgagg ggtcaatgca tagcccgaat 1990201 ccatctgtct tttgatagca aggatctgca tatctttatc cgtcaattca ttcagctgct 1990261 tatcagtaat ccgttttagc tgaagctggt ataaatcgtc atcggatatt tttttgtctt 1990321 caacctgctg tctttcttta gagctaatga gctttttcgc ttctttcggt ctagtcaaaa 1990381 tccaataatc ttttttatcc cgttctgtta ctttttttgt atcgactttg atcatgtcag 1990441 acagcttttt tgcgatcttt aagcgctgtt cttgcgtggt cgatttagat ctcgtgtatg 1990501 tgattgcatt taaagcctta tttgtcacaa tggcattaaa gtttcgatca taaattttcc 1990561 cgcgtggtac cgctgagctg acttcacttt gttcctgctt attcgcttgg tttttgtaat 1990621 catcaccttg cacgatctgc ttgatgccca gttccacaat aatccaggta aatataacaa 1990681 aggcagctaa aaataaaata ttcagccgga tcggaagcga cttctttttc tctttatgat 1990741 tttgcttttt tggtttattt ctcctcataa catcaccttt tctatttaca gaaagaaaag 1990801 acactcaagt aagagtgcca gttttcattt taaaggtttt ttcgactttt ttctacagat 1990861 aacccctttt tggcaaaaaa attatctctc gccttttaaa agggtcggtt ctgttacccg 1990921 tttttggccg tcttcttcca tggtttcatt ttccccttct ttctccttaa aacgaatatc 1990981 cttgacaaag taataaatca aaggatgtcc tatacccaat atcgcaagtg acaaaggaat 1991041 tcccacatcc tctttcagaa gggccacaat caggagaaag cacaaaatgg aaacaattct 1991101 gccggcgttc aagaacattt ctctaagcac gatatattca attcttgctt ttctggcatg 1991161 cctcgcgcgc cctatcacat catatgtaag tgatacatat ggcacaagca acagaggata 1991221 gccgatggca ataaaaacgc cgtacgttaa taatgtcgaa aagctcatat ggaacagaat 1991281 caaaaacagc gcgccataca aaataagtcc gcccagcaaa atcgattttt ttctcgcctt 1991341 tttcttaatc agcctggatg caaagtagta ggcaaagaag gaaacagctg aattgacaag 1991401 accgaatgta ccgagagcaa gctcgctgtt tgtctcaata aatacaaaca cactgattaa 1991461 aaagacaaaa atcccttctc tcaaaccctg aaaaaaatgc gcattcgtga ttctccgcca 1991521 attcatattg ctatggcgct ctccaaatac tttgctcagc ataaaacggc cctttgattc 1991581 tctccgtttt aagaaaaagc tcatcacgac agccagggca aataaactga gggagagact 1991641 gaaaatcact gtataacccg tattattttc aagccttgag atcacgaatc cggctacaat 1991701 cgggccgatc attcctgcag aggaagacag aatgcccata aacccgttga aaaagtctcg 1991761 tgtatccggc tctgttattt caaaggtcag cacgttaaac gctagccaat aaaagccata 1991821 gccaactccg agcaccgcgc cgattagcac gaggcggctg gccgccgttt ctccggctaa 1991881 aagcacactt aaataaaagg cagctaaaaa aatgacgccg aaccttaaaa tgaataccct 1991941 gtctattttt ttggctaacc gtccagccaa ataaaaggtt atcggctgca ttgtcacaat 1992001 ggataaatta tatatcgcca aatcaataaa tttccctgac tgcttccaaa gatacacatt 1992061 aacaaatgta ttggacagtg caattcccag cgagtaaagc ccgccaatgg tcagcagaaa 1992121 gagtaagcct ttgtttacgt ctacatcgcc tatcactttt tttagtttgc tcattactga 1992181 ctccccttta ctatccctta gtctgtctca ctcaaaccga gatatgtaaa aagaagacat 1992241 aaaaaaacaa ggtcccataa tgaggacctt gtttgtgcca ttattttgct tcgctgtata 1992301 gacgagccac ttcgtcccag tttacaacat tccagaaagc tgaaatgtaa tcaggacggc 1992361 ggttttgata gttaaggtag taagcatgct cccaaacgtc aagacctaag ataggcgttt 1992421 tgccttctga aagcggagaa tcttggtttg gcgtgcttgt gatttcaagt ttaccgttgt 1992481 tcacaacaag ccatgcccag ccagaaccga agcgtccagc tgctgctgct gcgaattgct 1992541 ctttgaattt gtcaaagctt ccaaatacac tgttaatctc ttcagcaagc gcgccagtcg 1992601 gttcgcctcc gccgtttgga gataaaagtg tccagaataa tttgtggttc gcgtgtccgc 1992661 cgccgttgtt gcggactgca gtgcggatgt tttcaggaac agaatcaaga tctgcaacaa 1992721 gctcttcaac tgatttgttg gcaagagcag tgtttccttc aaccgctttg tttaaatttg 1992781 tcacgtatgt gttgtggtgt ttcgtatggt gaatagtcat agtttccttg tcgatatgcg 1992841 gttctaaagc atcgtacgca taaggtaatt ctggaagttc gtaagccatg ataattcctc 1992901 cttagtatat atgtactgaa atgccgcttc acagcgagcc tttcttcatt caatgtaaca 1992961 aaagaatgct ttgtaatcaa tgaaaaagct cacgatttgg ctcatttcag cggacatatt 1993021 tcactttaac cgataatctg ccccattaaa cctgccgcca gcatttctta taggaccgtc 1993081 cataaaaagt aaccgatcat caaaagctgt atgatgccct ttgcaataac ccctgttaaa 1993141 aaaccaatga gtgagccgag gccaatttta aacgctgact ttaagtcctt ctgatggacg 1993201 ataagttctg cgcaaacagc cccgataaac ggccccaata tgatccctgc aaccggaatg 1993261 acaaaaggcc cgattaataa accgatcgtg cttccccata tggcagcttt gcttcctccg 1993321 aaccttttta ctccaagcag attcgacacg taatctgctg cgaataatac tgcggcaaaa 1993381 actgcctcaa caagccagaa catataagaa tacggactga atgaaaataa aaatccgtac 1993441 aatacaaatc cggcaacaat aaatactacg ctaggaataa caggatacac cagcccgata 1993501 aaggcaatga taaaaaccgc tgcaatcaac agccaataca acatatccat agcttccatc 1993561 ctcccatttt actctgtctt cttcatgtct tccttgtatt cacacgcatg caacgataca 1993621 ataagcaaca tatattagtt tagctaggaa gtgaagatag tgaatgtgtt tcagcttttc 1993681 attaaaagta catactctcc ccgtgatatt gcaaaaacaa gatttcaagg aatcggaaaa 1993741 gcgattcttt atgtattttt gctctctgtc ctgtttgcaa tccctaccgc ttattatgta 1993801 agtacaggga ccgtaaaatc aatgaacggc tttaaaactg ttttaaacaa agatttccct 1993861 gatttcacaa tttcaaacgg caaacttcaa acggatgaga aaaaagccac ggaatctcag 1993921 gcaaatggtt tcgttatcgt gttcgatccg acagactcct atggcactga acaaattgaa 1993981 gcaaagcaaa acgcaatcgg catccttcag aacaaatttg ttttggccat tgacggacaa 1994041 gcccaagaaa tgtcttactc aatgatgccg tcagagttac agaaaaaaga tgtcattgca 1994101 ggtttaaacc aaaataaagc gatgattgta actgttctct cagctcttat ttttctcgta 1994161 acagcagcgg gaaaatttat tgaagtatcg tttttagcgc ttatcgggtt aatcattaag 1994221 aattcgcaga aaaaacattt atcctatcat cagctctgga agctttctgc ttattccatc 1994281 acactttcaa ctgtattctt tacaatcatg cgggcactag aagcaaccgt accaagtgaa 1994341 tttttgctga actggtttgt caattttgtc atcctgtttc tcgttttaaa agagattccg 1994401 tccaaaaaag taattaataa aagttaaatt atatttattt ttatccttta agtagagagt 1994461 gtgaaagcat ttgcattaac tttttactta agggatattt aataaaatgt atagagctta 1994521 aacagataca tttataaaaa aagctctaca attactcaag aacaagctct ggacaataat 1994581 atcagaagta gtaagatgta acatgaaaga agttcttaac agcatttgac atatgttttt 1994641 aacaaaataa gaataatgtt aaattttaac taatagacta gttaaaatca tatggcaaaa 1994701 tattttgcat cctttcacaa catatttaca taagatagtt gctatttaaa aagccaggta 1994761 ccaatagggc acctagcttt cagaattaaa tcatcaacaa gttagaatta tcttctttcc 1994821 ttctattctc attattgaac tgttatcttt tttgtgggtt tatgtataca aatgcagctc 1994881 ccttagcttt ccccttatat actgataaac ctactgccca aggtgttcct gtcggttttg 1994941 gtaatttact gaagtaaaac tttttggttg gagttctact tgaaaagtac cctgaatatt 1995001 gcgggccaat gtccccaccc tcaactatag atacaccaaa gctcttataa tttagtttac 1995061 cgcattttcc atttgtttcg gcgtaagcat caatagatgt tgcactctta gtatatgtat 1995121 aagcatctgt aataactctt attttacaac cagaaatacc acttaccggt tgccaaccac 1995181 tgcttgcagc ctctgctttt tctttaggtg caactaccaa agttaacatt agtagcaaaa 1995241 ttaaaaacac agaaaatttt ccttgcttca ttttgtagat cctcctttaa actattacat 1995301 aattatccta acagatccat tgttcattgt aaataatgga atacgagttt tatattataa 1995361 aagcctcttt ttgatctaat tttgcactat tttctatttt ctatctgaag ttaatgttta 1995421 gtcgaagaaa tcctgtcaaa aaagcgcctg tataaaaacc gagcattcgc agtctctttt 1995481 cttttgtcat gaatcgaaat ggacaagcat actatggtat aaaatttcgt atgcgggagg 1995541 aaaagcgatg aagcgtctca ccttagtatg cagcattgtt tttatacttt ttattctttt 1995601 ttatgacctt aaaattggaa ccatacccat tcaggacctc cctgtctatg aagcatcagc 1995661 aaaaacggct gtacaagaac cggcttataa aacggtgaag gtaaagccgg gtgatacggt 1995721 tatgtcgata gtcggatcag caggttctcc ggatgacatt gtaaaggatt ttgaagcact 1995781 gaatccaaat gtgaaagcta acgccattca agccggaaca gcgtataaat tcccggtcta 1995841 cccttaattt aacgttaatt tcttgtcagt tcggcgaaga cactgttaca atgtaatttg 1995901 taaaataaat tcacataaac catactagaa ttgttatatc tagaagcggc aactacaatt 1995961 aaggagcgat tgcaagtgag tgaaatcaca catcgtacaa aaacgcgtcc cgtcaaagtg 1996021 ggacctttaa caataggcgg caacaatgaa gttgtcatcc aaagcatgac aacaacaaaa 1996081 acacatgatg tagaagcaac ggttgcggaa attaaccgtt tggctgaagc cggatgccaa 1996141 atcgttcggg tagcatgtcc ggatgaacgg gcggcaaacg ccattgcgga tattaaaaag 1996201 cgcatttcca ttcctctcgt tgttgacata catttcgatt ataaacttgc gttgaaagcc 1996261 attgaaggcg gcgcagataa aatccgaatc aaccccggca atatcggccg gcgcgaaaaa 1996321 gttgaagcgg ttgttaaagc ggccaaagac aaaggcattc cgatcagaat cggagtaaac 1996381 gccggttcat tggaaaaacg gattttagaa aaatacggtt atccgactgc cgatggaatg 1996441 gtagaaagcg cacttcatca cattaaaatt cttgaggatc ttgattttca cgatattatt 1996501 gtcagcatga aggcctctga cgtgaacctt gcaatcgagg cttatgaaaa agcagcgaaa 1996561 gcgtttgact acccgcttca cctcgggatc accgagtcag gaacactgtt tgccggcaca 1996621 gtaaagagcg cagcaggact cggcgccatt ttaagcaaag gcatcgggaa caccatgcgc 1996681 atttcactaa gcgcagaccc tgtagaagag gtaaaagtag caagggagct tctgaaatct 1996741 ttcggcttag cctccaatgc tgccacgctc atctcatgcc cgacttgcgg ccgtattgag 1996801 attgatctaa tcagcattgc caatgaagtg gaagagtata tttctaagat aaaagcgccg 1996861 attaaagttg ctgttctcgg ctgcgctgta aacggacctg gtgaagcgag agaagctgat 1996921 atcggaatcg ccggcgcacg cggtgaaggg ctgctgttcc ggaaagggaa aattgtccgt 1996981 aaggttccag aggaaacgat ggtagaagaa ctcaaaaaag aaattgacat tcttgctgag 1997041 gaacactacg caaaacttga agctgaaaaa gcaaaattaa aagaagaaac acaaaaagct 1997101 tgacgggaac ccgtcaagct tttttgtgtt agaaaaatgg aataataaat attccaagca 1997161 ctaatgaaac gacaccgata cccattgccc aggctccaag gccttgagca cctcttcttc 1997221 ttgcgatata gccgacaata ataccagcag ctcccaataa aacaggcagt acaaacaatg 1997281 aaatgatgga caaggctaaa gcgatgtacc ctattccccg tccttcattg acattgccgc 1997341 cgctgcgatc attgtcttgg tcattgctgc ggtcagcagc acgataaggc tctgcgattt 1997401 cagcagctgt ttcctcaaaa aaaccgtcat tgtcgcgggt aatatttgtc ccttcagatc 1997461 catgatcaac atagtaactg ttgttatcac gcttttcgta atcgtttgcc accttcaatt 1997521 cccccttctg ttttattaaa ggagctttta tagtttgatc cattttgcct gattcatgtt 1997581 tgctaaactt ttctgttaat gtcaattgtt tatgttacac ttgaagggat gaaactgaag 1997641 gagtgtgggc atgttacgct taggaataga tattgacggc acaatcacgg ctcaggatac 1997701 attcgtccct tatttgaacc gttcgtttaa tctttccatt tcattaaacg atatgacgga 1997761 ttatgattta acaaagctgt taaacattac ccaggaagaa ttttgggatt ggatgaatca 1997821 aaatgaagcg atcatatata aggaagcatt gcttgcacag catgcgaaac agtctctcga 1997881 tcttctcaaa gaggagcaca agcttattta tattacagcg agacggactc atttaactga 1997941 tattacttat gaatggtttg acagacaaaa cattcattat gaccacatcg aacttgttgg 1998001 gggtcatcac aaagttgaag cggtcaagaa tcataacatc gacctgtttt ttgaggatca 1998061 tcacgggaac gccatgatga ttgcgaaaga agccgggata ccggtgattt tgttcaattc 1998121 cccttataat cagcttccga ttgattcaaa catcatcaga gtaaacaact ggctagaagc 1998181 cgttcaatgg atgaacaaca acaagcatca cttaatacgc gtcaataact gaaaaaggag 1998241 cccaaaccgg gccccttttt catatatacg cattttacgc agtagtgttt tcttggtttt 1998301 ccgctgtaca atcagggcat gtgccataaa tctcaaattt atgcccgctg acctgatagc 1998361 catccaaatc atcacaaagc ttgtccatcg gacatgattc aatttccttt gttttgccgc 1998421 aggcaagaca aataaaatga tggtggtgat gggtgaatga acacttaaat cggaagagct 1998481 tttcaccgga cagctcagtt gtttccaaaa tcccaagttc ttcatataaa gaaagatttc 1998541 tgtagattgt atcaaagctt aagcctggat aatcatcatt cagtgcagac agtacgtttt 1998601 tagcggtaag atatctgtct gaatcagcaa aaagctgcag catatcctcc cgtttgtttg 1998661 tatatttata tccgttttct tttaataggt tcagcgcttc ttggacgttc atgaagggtc 1998721 ccccttttcg ctttgcttaa gaacgtatca catgtatgaa aaagaaaatg gcagctgtct 1998781 gtccagcaag ccattttctt tactgcagat aaaattatac ccataaaatg aataaaagta 1998841 aatgaaagcc tagtggattg cgtttttgaa ttttccgcct ctcgtttcat gagtattcat 1998901 aattgttatg aatgcatttt gatcaacttc aaacacgatc gatttgagct ttgtcacttc 1998961 cagccttgtg acaaccgcgt aaattacgtc tttttcttcg tccgtatacc cgcctttccc 1999021 cttcagcttc gttgtgcccc gaccgagacg gtgcaaaatc gcgtcggaaa tctcatcata 1999081 ctgctcagac acaataatga cagcttttgt ttcatcaagc ccttggatca cggcatcaat 1999141 cgttttcatc gcaatataat aagtcatgaa tgagtacatc gcttgctcag gaccgaacac 1999201 aaaaactgcc caaatgaaaa tgaacacatt gatgaacata acgaactcac ctacagaaaa 1999261 cgggagtttt ttggtcagca aaataccgag aatttctgta ccatccattg aacctccatt 1999321 tcgaataaca agcccgacgc caaagccgag taaaagacct ccgaacacag tagccaaaat 1999381 aggctgggtt gtaatggctt ctacatggtg aagtgaggat tcaataacgg caagcccgac 1999441 aatccctata aacgtagaga ctagaaaggt cttaccgata tatttatatc cgaagatcat 1999501 aaaaggaata tttaatatga caacgaaaaa agcgaaattc agaaaggggt ttgacataaa 1999561 gaggtggtct aaaataagag atacaccgat aatcccgcca tcaataaaat cattggggat 1999621 taaaaataat tcaatactta cagccgcaga tgcagctcct accagaatca taaagaccct 1999681 gaaaataaaa tgggtaaatg tttctttctt atgttgtttt gttggggtca taaaatctcc 1999741 tttcctgcaa taactatttt aaatacatta taaatctatt ttaccattaa acactgacac 1999801 attttactga tttgcccata cattaagtct ggaggtggaa tgaccgatga ttttatttca 1999861 aagaattatt ttgcagcggc ttaatcaggc tactgctgat gatttgctga agtactcaaa 1999921 acaatacgga atcagcttaa caagatcgca ggccgttgaa gtagcgaacc tgttatacgg 1999981 gaaaaatgta aacatcttta atgagagtga acgaatgcgg ctgctgaaac aagtagagac 2000041 gattacatcg aaagaaacag ctcaaacagt taatgaacta ttcaaacaat ttacaagcta 2000101 aaaaatgggg gtgttatccc ccatttttta ttgctgtaaa atcttttcaa gcaatgtatc 2000161 atcaaattgt ttttctttca gcatttcaat ctcaaaacgg tatggcggtt ttttgttctt 2000221 tttatcttca ccgacgtatg gtgtttcaag aatttttgga atgtctttta actgctcatg 2000281 gtgaacaaca tattgcagtg cgtcaaaacc tatttcacca aagccaatat tttcatggcg 2000341 gtcttttctc gcacctttga catttttgct gtcattgata tgaagcactt taatacggtc 2000401 aatgccaatg attttatcga actcatttag cactccgtca aagtcttcga caatgttata 2000461 cccggcatca tgtgtatggc acgtgtcaaa gcacactgac agctgctcat tgtgtgtaac 2000521 gccttcgata atctgcgcaa gctcctcaaa gcttctgccg cattctgatc cttttccagc 2000581 cattgtttct aatgcaatct ggacattttg attcggatca atcacttcat ttaagccttc 2000641 aataattttt ttgatgccgg cttcagctcc tgcccctacg tgagcgccag gatgaaggac 2000701 aatttgcttc gctccgatgg ccgctgtccg ttcaatttct gaacgaagaa aatcaacacc 2000761 cagctcaaaa gtggacggat ttgtcgtgtt gccaatatta ataatataag gcgcgtgtac 2000821 gataatctcg tcaatgccgt tttcttgcat atgtgcccgg cctgcttcta tatttaagtc 2000881 ttcaattttc tttcggcgcg tattttgcgg tgcgcctgta tagatcataa acgtattcgc 2000941 cccataagag actgcttcct ggcttgcagc cagaagcata tgttttccgc tcatagagac 2001001 gtgtgagcct attctcagca acaggttccc ctactttctt ttcttagatt ggtttcttct 2001061 ctgttttttc ttgattttct ccatctcata gctcattttc tttttatacc caggcttaac 2001121 cttcttcggc tttttcacga gacgatgagc aatttcatcc gcttcattcg gcgttttttt 2001181 acgttttttg cggcgctgac ggtcatcgcc ttttttccat tcgccctttt caagctctaa 2001241 gtactcaaat tcgatgccca ttttttcaag tcttactaat gcatcctcat cagtaagctc 2001301 ataaatggtc atcgcttgtc ctgatgagcc ggcacgagcc gttctgccca cacggtgaac 2001361 atagaaatcg agatcatccg gcagctcata gttgataaca tggctgacac ctttaatatc 2001421 aatacctctt gcggcaaggt cagttgcaat gatatatgtg aattccaaat cattgatctg 2001481 cttcatgact tttttccgct cacgtggtgt taatccgccg tgcagcaagc cgattttcat 2001541 gcctttgcca gtcagatact gggcaatatg gtcagccgta tttttcgtgt tggcaaacac 2001601 aatccccagg tatggattca gatgcgacat gatgtcaaaa aggagcttgt ccttgtcacg 2001661 atgtttcgaa ggaatgagga tatgctcgat tttcgcagca gtcacctgtt ttggctccac 2001721 atgggcgtat ttcggatttt ccatgtattt cttcaagaat ggtttcagct tttccggtat 2001781 ggtcgctgag aacacaagca tttgcagatc ctcaggcatg cgggaaccga tgtaatctac 2001841 atctgcaagg aatcccatgt ccagcattaa atccgcttca tcaataacaa gagattccgc 2001901 tttatgaaca cttaacgcct gttctttgat taagtcagca atccgtccag gtgtaccgac 2001961 aacaagatgc ggctgtattt tcaatttatc aattgatttt tgtttatcag tgcctccgat 2002021 aaaacatttc gagcgaatct gacttccttc ttcaccctgc gtgattttaa gcgcttcctg 2002081 ataaatctgg ttggcaagct ctcttgtcgg agccgtaatg actacctgaa cgacatcctt 2002141 agcaggatcg attttgttta ataaaggcag taaataagcg tgagtctttc cagtacccgt 2002201 ctgagactgg ccgatgacgc tttctttttt taacactgca ggaatcagcc ttttctggat 2002261 atcagtcggt tcgtaaaaac caaggcgatg tactgcatct ataataaatg gtttcaattc 2002321 ataaagttca aatttcgttt ctttcatttt tcccagctcc ttaaagcggc acattatgtg 2002381 tccatcatca cattataccc gattttgctt aaaaacacca cgtttgcaag gcgtttgttt 2002441 tattcagtta tgtaaagcaa ataccgcagc ccatgcatat tctaatagca gagagagctg 2002501 aaaggaggta caagtatgtt ttcaccgcag cagccaatga gaaattaccc acagcccgga 2002561 ccgccccgcc ccatgccaaa tcagcgaatg atgggcagaa gaccgcctaa tatgcgagga 2002621 ccttcatttg gagcacagca gcaaggtttt cagcaagccg gacaatttct tcctcaggca 2002681 aatgccggag cgagaaatgg tgcaggtgca ggcggaggct taaaaggaat gctgtcaagg 2002741 ttcctccccg gcggaggagg cgctggcagc gccggggttc ccggaattcc aggagcaggt 2002801 gcagcagcga gcggaggtgc tggcctgcaa ggcattcaaa atattgccaa tcctgcatca 2002861 ttatccagta tgcttggaaa tgtgcaaaaa gtactcggca tggcgcagca agtcacccct 2002921 atgatccagc agtacggccc attagtccgc aatctgccag caatgatgaa gctgtacagc 2002981 caattaagta aaagtgatga tactgagaca gaggccaatg aggaaagtga aaaacaatcc 2003041 gtttcagaag aatcatcaga aaaagaaaaa gagactgaaa caaaaacctc agatgggaac 2003101 aaaaaatcaa aaccaaaaag ttcttctctc ccaaagaaat ctaaaacaac tgacaataaa 2003161 gaacaagaat taaaaacatc tgccccgaag aaaaaggaag ctgcctctcc tgctccgaaa 2003221 agaacatcag gcagttcaaa accgagatta tatatttaac attctttgat atcttaagtg 2003281 agattggcta taatgagatc agaagaatgc aagaatagag ccgtttgatt acggcttttt 2003341 atattgcctt tactcacttc agtattggag gacaaccgaa aatggacgta attaaaattt 2003401 caccgcgcgg ctattgctat ggtgttgttg atgctatggt cattgccaaa aatgcgtcgc 2003461 tagataaaag cttgccaaga cccatctata tactcgggat gattgttcat aataaacacg 2003521 tcactgatgc gtttgaagag gaagggattt ttacattgga cggctctaac cgtctggaca 2003581 tcttaaagca ggttgacaaa ggaactgtca ttttcactgc gcacggtgtt tctcccgaag 2003641 tcagaagaat cgcagaagaa aaagggttag tcgcaattga tgctacatgt ccggatgtga 2003701 caaaaactca taatctaatc ttagagatga aagaaaaagg atatcacgtg atctatatcg 2003761 gcaaaaaagg gcatccagag cctgagggag ccgttggcgt agcgccggag atcgttcact 2003821 tagttgaaac agaagaagat gtaaagaacc ttgatatcca atctgagaag ttaatcgtga 2003881 cgaatcaaac aacaatgtct caatgggatg ttcacgacat tatggagctt gtcaaagaaa 2003941 aatatcctca tgtcgaatat caccaagaga tttgcctcgc tactcaagtg cggcaggaag 2004001 ctgtatcaga gcaggcaaaa aaagcggact taacaatcgt tgtcggagac ccgaaaagca 2004061 acaattcaaa taggcttgct caagtgtcag aggaaatagc cgggacaaaa gcataccgga 2004121 tcggcgactt aagcgaattg aagctcgaat ggctgaaagg cgttaatacc gttgcagtta 2004181 cagcgggagc ttcaacaccg acgccgatca caaaagaagt cattcgcttt ttagagcagt 2004241 ttgatcacga agatccatca acttggacaa ctgaacataa tataccgctc aaaaaaatac 2004301 ttccaaaagt aaaagcaaaa aactgaggct gtaaaagcct cagttttttt atagaaatgt 2004361 aaatggattt gtatctgttt cagaaacaaa gatattcacg ccaaactttt tatcattaca 2004421 cattgatgta agttttctcg tgacgccttc tttcatgatt ttttccgcgt aatggcccgg 2004481 atcaaccaca tttaggccaa gcatcatcgc atcatgggcc acatggaagt ataaatctcc 2004541 tgtgacgtaa acatcggctc cctttcgttt tgcatgatga atatacttgt ttccatctcc 2004601 gccaagaaca gctacttttt tcaccatgct gtcagcatcc ccaaccattc tgacaccatt 2004661 gacgtcaagc ttgtctttca caaataaagc gaattccttg agcgtcatct catttttaag 2004721 ggttccgaca cggccgagcc ctttttcggc gggagtctgt tcgacaggat agatatcgta 2004781 agcgacttct tcatatggat ggctttttat cattgcattg ataacagcct tttcgacgct 2004841 tttaggaaat acagtctcaa gccttacttc atgaacaagc tcaagctctc ccacttcacc 2004901 gataaaaggc ttagctccgt ccaatggctt aaagctgccg attccttcag atgaaaacgc 2004961 gcaatggctg tattcaccga tatggccggc ccccgcattt ccgagcgcgg ctctgacctg 2005021 ctcttcatat tccttcggca cgtaaactgc cagctttttc agaggatccg tataagtagg 2005081 tgccagcact tccgtctcac tcagctctaa tgcttcagca agcaaatcat tcacaccgcc 2005141 gtccgcaacg tctaaatttg tatgagctgc ataaacagca atatcatgct tcaaacactt 2005201 ttcaattaac cttccggcag gctgatctgt tgaaatatgc tttagcgacc ggaaaattgg 2005261 tggatggtgt gcaataatca agtcaacctc tttttcaatc gcttcatcga taacgctctc 2005321 taacacatca agtgtaacca tcacattttt aattggtttg tttaaggtgc cgatttgcag 2005381 gccgatttta tctccttcaa ccgcataggc tttcggggaa aattgttcaa acagctggat 2005441 gatctgctgc ccatttacac ttttagccat gatcgattac ctcctttaac agctccattc 2005501 gatcggcgag ctcctttaat ttttgtttgt tttgctctgt atccgccgct tggctgatct 2005561 gttcataaat gctttgagtg tgctgaagct cttgtgtcca ctttttcaaa aagacagcat 2005621 ttttttcttt tgccaagaaa gggccaacga gcatcccggc tgataaagaa ataccgtcat 2005681 aagccgcatc cctgtctccc gcttctgcca ccagcacctc atagcacttt ccgtcctctt 2005741 caaggattac ctcatctatc agcgcatatc tttctttata aagccactcc ctgatatgaa 2005801 cagcatgaat attcggctgt aaaatgagcc gttccttccc cgttaatttg tctttgcccg 2005861 cttctaaaat gtgagcgatc aaagccccgc ccattccggc aatcgtaatg gcatcagctt 2005921 cacctttttt aatcacttcc agtccgtctc cctgccttac agaaatgtgc gagtttaagc 2005981 ctgatttttc aacctgccgc tttgcagaca aaaatgggcc gtctgttatt tctccggcaa 2006041 tcgccccgct ggctttatga ttcagcaccg cataacaagg aaggtaggcg tggtcagagc 2006101 cgatatcggc catcaccgct ccattcggta tgtactccgc tactgtttgc aatcgtttag 2006161 ataattttaa ttcgttcact tgtcatcaca acttttctca atcatttttt cctttactat 2006221 catataaaaa atcagcccgg aatccaagct gaagcaaatg attttgaaat tatttctttt 2006281 gatgcgggtc tgcacgcagc agtcaaaaat aaaaggctgt cgagaacatc tcggcggcct 2006341 gtgaatgtat aaagagaaaa atagttcttt tatttaattt ttgacaccca ctctgccata 2006401 tcatccagct tatcggccgg aacaagaccg gaaggcattc cattaccgcc tttttcgatc 2006461 tttgttttaa tttcagcgac atctttctta tcccctacac cttttaagct aggacccgaa 2006521 acaccttcat aattttcacc gtggcatgcg atgcagtttg ccttgtaaat ttcttctggt 2006581 gaagcgtttg catctttctt ttcagcagat ttgctttctc ctccgctcgc aatctcccga 2006641 gagtcatcaa gtccttttac tgataaaaag aaagttagac caattcctaa aacagcgatc 2006701 agcaaaaatg gaataagcgg gttccatttc atttcccttc cccctttttg atccttcccc 2006761 ctatgtaaac acttctaatt ctaacttatt tttacaaaaa gtaaatggat tgctatacaa 2006821 aagtttttta ttcacacttt atacaaaatt gaatagaaac atgcctaaat ctctaatatc 2006881 ctttttattc tattgtataa tgtattgtat acgcttacaa tagaaaatat ggaattagat 2006941 tttgaaattt ttcaccacaa tgttcatttg caaatgacat catttttcag taaaataaag 2007001 gcatattatc catatatctt tttaaaaaaa gaagaacgga tcttcaagac ccgttccatc 2007061 ttattcaagg aaatctttca aacgtttact tctgctagga tgtcttagtt tccgcaacgc 2007121 tttggcttcg atttgtcgaa tacgctctct cgttactcca aatactttgc cgacctcttc 2007181 taatgttctt gtacggccgt catcaagacc gaatcgaaga cgcaatacat tttcttcacg 2007241 atcagttaac gtatcaagca catcttccag ctgctctttc aatagctcgt atgcggcgtg 2007301 gtcagaaggt gaagttgctt cttggtcttc aatgaaatca ccaaggtgcg agtcatcctc 2007361 ttcaccgatc ggtgtttcca gagataccgg ctcttgagca atctttaaga tttcgcgtac 2007421 tttttcaggc gttaaatcca tatcttccgc aatttcttca ggtgttggtt ctctgcctaa 2007481 gtcttgcagt aattgacgct gcacacggat taatttatta atggtttcaa ccatatgaac 2007541 gggaatccgg atcgttctcg cctgatcggc aatggcgcgt gtaatcgcct gtctgatcca 2007601 ccacgtagca tacgtactga atttataacc tttgcgataa tcaaattttt caacggcttt 2007661 catcaggccc atgtttcctt cctggatcag atcaaggaac agcataccgc gtccgacata 2007721 ccgttttgcg atactgacaa caagccgcag gttcgcttca gccaatctgc gtttagattc 2007781 ttcgtcacct tcttcaatct tttgagcgta ggcgatttct tcttttgcag aaagaaggtt 2007841 aacccgaccg atttccttta aatacatacg aactgggtca ttgattttaa cgccaggcgg 2007901 tacacttagg tcattaaggt caaattcttc ttcggctttg gcaagctgct gaatattagg 2007961 atcttctgtt tcttcattct cactaattaa ttcaacacct tgttcaccta aaaattcata 2008021 atactcatcc atttggtctg attcaatttc aaagctggac atacgctcag caatttcttc 2008081 atatgtcaaa acgccacgtt ttttaccaga ctctgttaat tgctctttta cttggtcgaa 2008141 tgttaattct gtctcgtggg tttgtttatc agccattatg gatccctcct tccaaagctt 2008201 gcaacgaatt ctataagcgg tatgattctt attcggtcca ttcaggcgtt ttctatgtga 2008261 actgccttta acaatgtgcg aataatgaaa tgacaattca tgatgaggtt aagcgatcta 2008321 tttgctcctc cgcaaggaat cattgccaat aaatgctcct catcagttct ccagttattt 2008381 taaagatcgg ttcaatgtaa cgatttcttg agccaaagaa gcagctctta aaaaatcttt 2008441 ttgcctttct gcttcggctc tttccgcctc tttttctttt atcattgacc aatttctttg 2008501 attcaacact ttttttacat aatctgataa ctcggcttcg ctaagctctt gattaacctg 2008561 aagcattaat atatcggaca agagctggct tatatgatca tccgtcaccc tggccatcag 2008621 atgctgaggc gtcagctcgg ctccctcttc ataaaaagca taaagataag cggctaatgc 2008681 ccggtgctca tcaatattaa attgaaaccc tacccggtca atcacttttt tgatgacgct 2008741 ccgatctcga agcatgtgag cgagtaacag cctttctgca ttttcatacg ccggacgcaa 2008801 acgtttttgc cttgcttttg tcgtcagatg cgctcgccgc gttttagttt caccgctatt 2008861 gtcagcaggt ttgttttgct tgctgaaaac agacagctgc tcagttaaag actcctgtga 2008921 aagcgaaaac tctgaagcaa gctgctttac atagacttcc tgctctagag accctgaaag 2008981 cgtgctgatt tctttcagta cgtctttaat gtaagctagg cggtcgcctt catcggacag 2009041 gttctttcct tttcggaaat attgcatttt gaacgccatt acggtgacac ttgcgtcaat 2009101 aatgtcgttt ttaaattttt ccccgccgaa ttttttgatg taatcatcag ggtccaatcc 2009161 gtcaggaatc attgcaactc tgactttgca gccttttttt tgcagaagct ccgaagcttt 2009221 taaggtggct tcataaccgg ctttatcaga gtcatagcaa agaatgattt cttcgacgtt 2009281 tcttctcagg atcttgacat gatcatctgt aagagacgtt cccatcgtgg ctatgctttc 2009341 ctttacatcc gagcttacgg ccgatatgac atcagcaaac ccttcaaata agactgctct 2009401 ttcctgcttt ctgatatgaa ggcgggcctt ataaaaattg taaagcagtt tgcttttatg 2009461 aaagagcggg gtttcaggac tgttcatata cttaggctgc tggctgccaa gagccctgcc 2009521 tgagaaagca acaacagccc cgtgatgatc atggatcgga aacatgacac ggtttctgaa 2009581 gcggtcgaaa tatccgcttc cgtcttcgcg tctgatcagg agacccgctt tttccatttg 2009641 cgcctcacta aatcccctct ttacaaggaa tttcgtgata aagtcccaag aatcaagagc 2009701 atagccaatc tgaaattcat taatcagctc tttcgtaaag cccctagaaa gcagataatc 2009761 cagtgcctct tgaccttctt ttgtatttat taacaaatga tggtaaaatt tcttcaggag 2009821 ctcatgtgcc tcagccattt tttgttctcc agaagactct ggccgggctc cggaatggac 2009881 tgttatatca tctggaaaat caatttggta tttgtcagca aggtgagaaa ccgactcggc 2009941 aaaagaatag ccttccatct gccttaaaaa agagaaaaca ttgccgcccg ctccgcagcc 2010001 aaagcaatga aaaatctgtt tgtcgggcga tacggaaaac gaaggtgtgc tttctccatg 2010061 aaaaggacag agtccaaagt agtttcggcc ttgcttcttt aattgaacat aatcacctat 2010121 gacttcaacg atatctgccg acttttgcac ctgatccaca atttcatctg gtatccgatt 2010181 tcccatctta taacactccg tcgtacatta ttcgatgctt tagtgcaaaa tcccttcatc 2010241 gttcgacagg attttttgca gcagtgtaat aaatcgttct cgatcttctt tattcaattt 2010301 tttaggccct ttggcatata cgccttttct tctttgtttg ccggaaaaat gacggccctc 2010361 tagggcaaaa tcaatcgtgt cttccttgta aagacgacct ctttccgaca taacagagac 2010421 atttctgttc aacagcagag atgctaatcc gatgtcctgc gtcacaacaa tatctcccgg 2010481 tttcacgtga tttgcgatat ataaatcagc agcttcttta tgaggatcaa catacttcca 2010541 tttttcttca ttgcttctgg aaagctgata atgttcaaat gaagcgacaa aaagaacttg 2010601 aacttcatac tcggatgctg tttgtaaaat ttcatctttt accggacaag catcagcatc 2010661 gacaaaaatc gtcttttctt gttcattaag aagagtaatt ctccatccct ccattaaact 2010721 cctgcataaa agcaagcaaa atcgcacatc ctttattatt gtggatgtat atgaatttgt 2010781 cgaaaaattt ccgggagaaa ttcttgacat cttacccata atagtttatt cgtatcacac 2010841 gatccttaaa cctaaaatta atcattttat cacaattttt tattataata caaacttcac 2010901 aaagatgcta ttgtttttca ttattccctt ttggcacagc caaaaaccca ggatagagcg 2010961 tcctgagtta tatgtttttt gttttgagat gatggataat atttgctgtt tcctcaaccg 2011021 ctttatttga aacatcaaca acctggcagc cgatccgatc cacaatcttt tcgaaatact 2011081 cgagttcctc tttgattctg ttgatatttg cataaatcgc tttatcatta agcccgagtg 2011141 attttaaacg ttcttttctg atatgattca gtttatcagg gctaatcttt aaaccgatgc 2011201 attttttcgg atcaacgtta aagagttctt ccggcggatc aacctccggt acaatcggaa 2011261 cattggcaac cttcaggcgt ttgtgtgcga gatattgaga cagcggtgtt ttagacgttc 2011321 ttgacacgcc gatcaaaacg atatcagctt ttaaaatccc tcttggatca cgtccatcat 2011381 cgtatttaac tgcaaactcg atggcctcca cttttttgaa ataatcttca tcaagctggc 2011441 gcacccgccc cggttcgtat ttcgctgtta aaccgtaggc tgtttccatt ttatcaatca 2011501 acgggccgat aatatcataa tataaaacat ttgctttttc cgcttcggct atcaaatatt 2011561 ctctgatttc cggcaccacg agtgtaaaac agataatgcc gccgtctgcc tttgcaagtg 2011621 aaatcacttc attgatagtg cctatatctt caacataagg aattcttctt acatgagtat 2011681 catccgccga tccgttaaat tggctgagtg ctgcttttac taccaattca gccgtttcac 2011741 cgacggaatc cgatacaaca tagatgatgc ggttattcat attatccccc cgttagtttg 2011801 caatcttata ggatttcatt ttcagataaa ctgacaagta ttttggtcat atttgttttt 2011861 gtcactctgc cgatcacttc aaagccttta tcggtgtctt tgatgacagg cagtgcatca 2011921 atttgttttt ctattaagtg ctttgcaatg tccatcacat aatcctcgcg tctgcacacc 2011981 gtaatgttcg gcatccttgt catgatgatg tgaacaggga ccgatgtaag ctcctgctgg 2012041 ccaatgctcg ctctgagcaa gtcttttcgt gaaagcaccc cgactaaaac agcatcgcgg 2012101 tccaccacaa acagagtacc tacatcttct aaaaacatgg tgcaaatcgc atcgtacaca 2012161 gaaacgtttt cgtgaatcac tacggggata gattgaaagt ctttcacctg aagctttttg 2012221 agtttatccg ccaaaagctg tgtgccggtt tttcccgtat agaaataacc gactctcggg 2012281 cgcgcctcga ggaatcctga catggtgagt atggctaaat ccgggcgcaa tgtcgccctg 2012341 gttaggttca gcttttctgc aatatgctcc cctgtaatcg gcccgttttc ttttacaatc 2012401 tgcaaaatat gttcttgccg tttatttagt tcgatcgtac tcaccacctt ttcacttcat 2012461 agctatgtaa agaaataaca atccatatta taacgtaaat atcttgtaat caaacaaaaa 2012521 acttataaat ggggaaaaga cgattaccga tcacacagca accgcctttt ctctctttat 2012581 tttacaataa gggcattcat attcgcaaag gacttgatct catccgccaa gcttaccatt 2012641 tgcgctaaac gatttgcctt taatgactca ttatccgcta taaccattgt atgatcgaag 2012701 taagcatcga tcggttcttt taaggctgca agtgaagcaa gcgccgcctc ataatctttt 2012761 ttgctgaagt tttcctgcag attttgcttc gctgtttggt aggcatcaaa cagttttgct 2012821 tcgtattcat tttcaaacag atcaggctga atgtctccgc ggactccttt tttgctgata 2012881 gagatcactc ggcctaacgc ttcggctgtt tccttaaagc caggtgcacc aagcttttgc 2012941 tccagtactt gtgctttatg cagcgcagag tacggctcaa gctcagagct ttccagcacg 2013001 gcgtcaatga catcatgtct gatttgttca gcattcaaga catatttcaa gcgctgagtg 2013061 aagaaatcca gcagttcatt ttctttatcg gtttgaacga aagtaagcag ctcttcaaat 2013121 gaaattcccc agttgcggtc aagaagaatc gcaacaatac cgcttgcttg gcggcgcagt 2013181 ccgtaagggt cctgggaacc ggtcggaatt acgccgatag agaagaatga agcgattgtg 2013241 tcaagcttat ccgccattgc tacaacagct ccggtgaaag tagaaggcgt ttctccgccc 2013301 gctgatctag gcatataatg ttcattaact gccgcagcca cagcttcatc ttcgccaagc 2013361 attctcgcat acttttcgcc cataattcct tgaagttcag ggaattcata tatcatatgc 2013421 gtcacaaggt cgaatttaga aatttcagca gcccgcttca catgttttaa tgtatcttca 2013481 tcagcctgaa gacgaacggc aagtttctct gcgattgatg tgactctcct aaccttatca 2013541 gcaagagaac caagctcttc atggaaaacg atattttcaa gcttcttcac atttgcatca 2013601 atgtttagtt tctgatcttc tttgtagaag aatgaagcat cagataaacg tgcgcgcagc 2013661 actttttcat tgcctcgggc cacattttca atcgcgtggc tgttgccgtt tcggactgtg 2013721 ataaagtgag gcagcaggtc accgtttttg tctttgacag ggaagtagcg ctgatgctct 2013781 ttcattgtcg tgacaagcac ttcttcagga attgacagaa actcggattc aaatgaaccg 2013841 taaagagctg tcgggtattc tactaaatga ttcacttcat caagaaggtc ttcgtcaact 2013901 ggaatgctcc aattgttttc agcagccatt gtttccagct gagattgaat catttgcttt 2013961 cggacgctag gatcagcaat aacatgctgt cctttgagct gctcttcata agctgaaggt 2014021 gattcaattg acacttcatg tccgaggaaa cggtgtccct gtgttgtccg tccagactca 2014081 acgtttgtga tcgaaaatgg aatgacatcc tgtccaaata atgcgacaat ccatttgatc 2014141 ggtcggatat aacgcaaatc ttcatttccc cagcgcatgt ttttcgggaa atgcaagctt 2014201 gtaattaaac cgctcaattc tggcagaagc gacttcgttt cttggccggc ttggaatttt 2014261 tgcacgaata catactctat gccttttact tctttgatgt acaggtcttc cacatttgcg 2014321 ccttggcctt ttgaaaagcc gattgccgct tttgtccagt tcccgtccgc atcaagggca 2014381 atttttttcg caggcccttt tgcttcttct tttatatcat cctgcttttc tgcgacatcc 2014441 ttaacgaaca cagcaagacg tctcggtgta ttgaagagtt tcacttcacc gtgagtaata 2014501 tttttttctt taagccagcc tgtcagcttg tcgccaagct gaaccatgct ttcattcaaa 2014561 aagcgcgccg gcatttcctc taatccgatc tctaaaagta aatcctgttt actcatgaga 2014621 agaaccctcc cctttaagca ttgggaaccc tagtttttct cgttcctcat agtaggtttt 2014681 tgctactttt ctagctaaat tccgcactct tgcgatatag cccgtccgct cggtaacaga 2014741 gatcgcacct ttggcatcaa gcaggttgaa agtgtgcgag catttcagca catagtcata 2014801 tgctggatga acaagtccgt tgtccatttg cttgatcgct tctttttcat atgtgctgaa 2014861 caattggaac agcatatcga cgtctgatgt ttcaaacgta taaacagaat gctcatattc 2014921 agccatcatg aataaatctt ttactgtaaa ccctgacgtc cattccaagt caaacacgtt 2014981 ttctttatcc tggatataag acgcgagacg ctcaattcca tacgtaatct ctacagaaac 2015041 gggtttacac tctaatcccc cgacctgctg gaaatacgta aattgtgtta tttccattcc 2015101 gtcaagccaa acttcccagc ctagacccgc gcagcctaaa gacggattct cccagttgtc 2015161 ttcaacaaag cgaatatcgt gctcaagcgg atcaattcca agagcacgca aggaatccaa 2015221 atacagctct tgaatgttat caggtgacgg tttaataatg acctggaact gatgatgctg 2015281 atacagtctg ttcgggttct ccccgtagcg gccgtctgcc ggacgtctgg aaggctctac 2015341 ataagccact ttccacggct caggaccgat actgcgcaaa aatgtatacg ggctcatcgt 2015401 gccggctcct ttttctacat cgtaagcctg cataagcaca cagccctgac tggaccaatg 2015461 cttttgcaag gttagaatca tgtcttgaat attcatttca agcacctcca cttttctttc 2015521 ataagttgac tgcggcagca accaaaaaac tcccgtctct atgcttgcca gccgcaaaca 2015581 tagggacgag agttctcccg cggttccacc ctagttgctg agaacaaaat cccagcctct 2015641 tttttaaaat tgctcaagaa tgcctttcgt tgcgtgctca tccttagctt acaccgccct 2015701 aaggtcgctt tcatgaggta aacgcaagta cttctttctc tcactgcaac atattttata 2015761 ataaatgatc atataaaaag atggaccaaa tgtcaacttt tgttttcacc cataagatgt 2015821 ttcatgcttt ccatttgatc taaaaagcgc tttgatttta aatacaatcc cgaatattct 2015881 tcgtaatata aatcaatcac ttgctttaat tcagcttttg tttcctcttt taaggacaca 2015941 ttgccgagtc tcgacagatc aaaatagtaa aagagcctta acagccttgc cgtttgcggt 2016001 ttaatcggta tcctgtaagg atctttttca aaacagcggt ggcatataaa accattatca 2016061 cgaacagaga aatgaaaggt tccgtcttgg cttttacaat gtacacaatg attcagctca 2016121 ggatacaggc ccatgacacc gagcatcttc atttgaacaa tgaaggtgat aacatccgga 2016181 tctgttcctt cattcaactg ttttaatgat tctaatatga attcaaataa ataaggattt 2016241 ggcttttttt cttctgtgcc tctgtcgact aactcagcaa cataggcagc atatgctgtt 2016301 aaaaacaagt cttccctgat gcctctcatg ctgaggatca tttccccctg ctgaagcgtt 2016361 ccgaggcccg atgttttttg cattaagaaa gaaccataca aaaagggctg gctgactgct 2016421 gataaacggc tgttcggttt tttggcgcct cgtgccataa cacctatttt tccgtgttct 2016481 cttgtcagta atgttacgat tttattcgtc tctccgtaat catttgtgcg aagaacgatc 2016541 ccttcacatt ttgtcagcat ttccgcacct tcctcaagca ggagcggcca agaggtttat 2016601 aaaattggat aatcaaatcg ggctagctca tcttctagtt cttcgggtct ttccatgttc 2016661 tctttttcca gttctttaaa aagaagatac gtatcaacat ttcctgtttg agaaaatacg 2016721 ttccaggtaa aattcaacac aagaaaccca cctttctgta gttaaactag cttacctaaa 2016781 ctccaaattc ttacctttat cttgaccaga tgtcctccat ttcatgttaa acaaaatttg 2016841 ctaatgtatc cctgttcctg tgagataatg acacacacgg gaagagatta atattcgtcc 2016901 tctttaaagc caaaatcgcg aagctgggac attttattac gccagtcttt ctgcactttc 2016961 acccacaatt caaggtagac acgggagccc aacagtgctt caatatccgc tctcgctctt 2017021 tttccaacct cttttagaag gcttcctttt ttaccgatca cgatgccttt ctgggaatcc 2017081 cgctcgacca caatcgttgc cgctacgtgc acagaaccgt tgtcctgccc tttgatggat 2017141 tcgatggcca ccgcaatgct gtgcgggatt tcttctctcg tcaaatgcag caccttttcc 2017201 ctgattaatt cagaaatgat aaatcgttca gggtggtcag ttacctggtc actcggatag 2017261 aattgcggcc cttccggcaa atacgcttcg atctgcgcga gcaaggtttc gatgttattt 2017321 ccttctaaag cagaaatcgg aacaatttcc ttaaaaggat aacgtttgcg gtattcgtca 2017381 attagcagaa gcaattggtc gggatgaatt ttatcaattt tgtttacgat taagaataca 2017441 ggcgtagaca tcgtctgcaa tttctcaatg atgaattcgt cgcccttccc gtagccttcc 2017501 tcagcattga tcataaacaa gatcaaatcg acttctttta atgtattttg cgccactttc 2017561 atcataaagt ccccaagttt atgcttaggt ttatgaatcc ctggtgtgtc aataaaaatg 2017621 gtttgtgatg tgcctgtcgt cagtactcct tgcaccttgt ttctcgtcgt ttggggctta 2017681 tcgctcatga tcgcgatttt ttgtccaatg actctgttca aaaatgtaga ttttcctacg 2017741 tttggtcttc caataatgga tacaaatcct gatttaaagc tttcgttcgt catgtaaatc 2017801 ctccgatgaa aatgcgcctg gcaataattc ttccacagtc atttctttta tttgtccttg 2017861 taaattagtc agtacgacaa taacgtcttt tgtgcaaagc tcagaaatca cctgtcggca 2017921 ggctccgcac ggagatactg gtccaggggt gtcagccgca acggccagca tctgaaactc 2017981 tgtatcccct tcagaaacag ctttaaataa agcggtacgc tcggcgcaat tgcacatgct 2018041 gtatgccgcg ttctcaatat tgcagcctct gtacactttt ccatccttgg taagaagagc 2018101 ggctcctact tggaatttgg aatacggcgc atatgccata tcacgcgctt ttaaagcttc 2018161 tgttattaat tcttgtctgt tcatgtgtac attcctctct tacctataat ggtaccgcta 2018221 tcactttata ttttacataa tcgcgcgctt tttttcacgc ccatttctaa aaatgtaaaa 2018281 taaatgtaag aattttcagc cattacagct ttggcaaaaa aataagtaaa ccaatgatac 2018341 acgaaatcac ggcaaaaacg caaacagccc cggcggcagc gtccttggcc gctttagcaa 2018401 gagggtgatg tttgtcagtt attaaatcaa ccgtatgttc aatggctgta tttaaaagtt 2018461 caagcgaaaa cataccacct atcaaaagga atataatcat ccactcaata atgctgagct 2018521 ctacaaggaa gccgcaaatg agaacagcgc aggcggctgc ggcatgaaat tggaaattcc 2018581 gctccgtccg cgctgtttcc catatgcccc ggcctgcatg cacgaagctt ttgaagaatc 2018641 gattcagctc atttctatga tcttttgagt ccataagcgt ccagcaattc cttttgctta 2018701 gtaaacatct cctcttcttc ctctttcgtc atatggtcat atcctaaaag gtgcagaaat 2018761 ccgtgtacag ctagaaatcc gagctctctt ttaaaagaat gattatactc ctctgcctgc 2018821 tctcttgtgc gatcggcact gatgataata tcacctaaaa ccggaggcat ttcggcgccc 2018881 acgatttcga tctcgccttc tccctcttct tcaagagcaa atgagatgac atctgtcgga 2018941 gcatcctttc cccggtattc tttgttaatc tgatgtatgt catcattgga aacaatcgtg 2019001 acagaaactt cagcctgatc ctgaacgcct tcacgctcag cggcaaattg aagcagattt 2019061 tctacttctt tgagcatctc ttctgagacg cttcccgttt catcaacgat atcaatcagt 2019121 aaactcatct atttcacctt cttagtagcc tccggatatt caatccggga gtggaaaatt 2019181 ccttttaatg ttgcacagag cgtttttgcg attgtatcca gctctttaaa tgtcaaatcg 2019241 cattcactga actgtccgtc ctgaagctta tcggatataa taccccggac aagcttttca 2019301 attcgttcag gatttggatt gtgcatggat ctgacggccg cttcaacact gtcggccact 2019361 gatataattg cggcttcctt tgactgcggc ttcggtcccg gataacggaa ctcttcctct 2019421 gtaatctggt cgcctttttc cttcgcttta tagtaaaaaa actttaaaag cgaggttcca 2019481 tgatgctgct cagcaatatc gacaagctct ttcggaaatt tatagcttct cagcatattc 2019541 gcaccgtctg tcgtatgcga gataataata tttttgctca actgaggtga cagcttgtca 2019601 tgcggattgt caatattcat ttggttttca ataaaatatt gcgggcgctt tgtttttccg 2019661 agatcgtgat aatatgcgcc gactcttgca agcaaaccat tagccccaac cgcttcacag 2019721 gctgcctctg ataaattggc aaccattaca ctgtgatgat atgtacctgg tgtttccgtc 2019781 agtattttgc gcaatagcgg atggttagga ttagacagct cgagcagcct catggtggat 2019841 aaaatgccaa agcccgtctc aaaaaacggc atcagaccga tgatcaatac agatgaagca 2019901 aaccccgaca caacccccat gagcattaac gtgccgattt caagacccga cagcgcagtg 2019961 ttctggatca ataataagga tagaacgaca accatattaa taaacgccac gaaaagtccg 2020021 gtctgcaaaa tctttgatct tgcattgtgt tttcctaaaa ataatacacc tgaaatgccg 2020081 ctgatcaaat aataaatccc tatgacataa ttgaatgttc ctgtcacacc ctgattaaac 2020141 atcatacttc cgcaaatcgc aagaatgata cttcccaaaa tggcaatgcg ttcattcatc 2020201 agcagtttga ttaagatggc gccggccgca atggggacca gatagccgat attattatac 2020261 tccatcttct gaaacaaact gacaacctcc atgatcacaa gcaaaagtgt tgtgattatg 2020321 gagaataaca gaatggattg gtttttaaac ttcagatttt gtttctgttt ttcaaaataa 2020381 tatacaagtg ttgcaatgaa aagtccgatc ataatcaata gcccgctgat cggtttaaag 2020441 agatttgagt tatttaataa cccggtcagc tcaagtttcc tgtacacttc ccgatcaatg 2020501 aggtcatttt cttccacgag cacttgcccc tgtttgattt gaacctgctg gacattatct 2020561 gaggcttcct gccgttttgc ctctgttgct ttcggatcga agacgtaatt cggaataata 2020621 gcaaaacgcc cgatttctgt cgcggctccc aagtatttag acggaataga attgctcttt 2020681 agctcttttt ctaccttatc ctttgcatca gatagtttat ccgaagggat ttcactgctc 2020741 atgaccgtat ttaccgcggt aatgaccgta tctctgacaa aagaaaagtc ttcactgtct 2020801 gctttcagca atgtcttgat ggaatcctcc gatatagaat cattcacatc tgatgtcaat 2020861 ttgtccttta cagatttgac cattgatttt tccgatggtg atttactgcc ttcttccgat 2020921 gattttttca cttcactaat actgtcgaat attgatgaca caaggtcaat ccgattgtct 2020981 gtatattctt tttttaatgt atattgatct tcaaccgcgt cctcagcggc ttgctttttt 2021041 tcctctgtgg ctttttgatc ttctacggtt gccggagcgt aaatggtctt gtcgctgact 2021101 gaaaacaggt ctaaatcaag tgtttccggc ttaacatgta caaagagcaa agcaaacata 2021161 atggcagcca gcagaagata cagcagtaca tgcatggagc gggcattttt aaaactgctc 2021221 catttttttg agctgctttt ggtcttagcc ttctttttca acacaagaac ctcctcttga 2021281 aacatcaagc ccataagcaa tcataaaaat gacccgataa cgcgcgatcg ggtcattcag 2021341 cattaatttt gcttatcgta tgcttcaata attttcgcaa caagcggatg tctgaccacg 2021401 tctgtctggt ctagctcaat catagaaatg ccgtctattc ctttcagcat ctccttcgct 2021461 actgcaagtc ccgatttgac gcctttcggc agatcaattt ggctaacgtc acctgtaatg 2021521 atcattttag agccaaaacc cagtctcgtc aaaaacattt tcatttgagc aggcgtggta 2021581 ttctgtgctt catcaagtat aacataagca tcatcgagcg tccgtcccct catatatgcg 2021641 agcggagcaa tttcaatgat gcctctttcc atcagacgtt ctgtatgatc tgccccaagc 2021701 acatcatgga gagcgtcata cagcgggcgc aaataaggat ctactttttc ttttaggtca 2021761 cctgggagaa aaccaaggct ttcaccggct tccacggcag gtcttgttaa aatgattttt 2021821 ttgatatgtc cgttttttaa agcatggact gcttttacga cagccaggta cgttttcccg 2021881 gttcccgccg gaccaatgcc gaatacaagg tcattccgct tcatagcggc cacgtattcc 2021941 cgctgtccca ttgtttttac acggattgat ttgccttttg cgttttttgt aatttcttct 2022001 tcatacatgc tttcaaagta ttcaagttca ttcttctttg ccattttgat ggcgtaaatc 2022061 acatcacgtt cagagatctc tatccccttg cgaattaaag cgaggagcga tcccagcagc 2022121 ctgtctgcaa tctgaaacga ttcatcatcg cctgaaacat aaatcgtctc gccgcgcgta 2022181 atgatattta aattcagatc tttctccatc aatttcaaaa aagaatcttg gttcccgaag 2022241 agtgaaagcg cctcgtccgg gtttttcagt ttttgattca tcgcaagtaa atgttctgtc 2022301 attcttcagt ctccctgaca ataggtgtgg tttgaacgat atcttctata acttggtaga 2022361 gaataatcaa ctttacttta ccattctcaa cagtctggtg caaaactttt tcacttttca 2022421 cctcgccgtt ttcgcctatt ttatcctcta catcctgttt acccaattta atgccttctt 2022481 gaactgcttc ttcttttgta tattttcgca aagcctcttc actttctctc gtttgctctt 2022541 tgacatagga tacagggagc ttaaatccga gaaaatgaag cgaatgcttt tcttgttctg 2022601 tttttggatg cttcaattcc tcttttttaa acgtcatccc ccagatcggg attgccaaag 2022661 aaccaaaaga aagcttgtgc tttgtcctta ctttgcccgt atagacgtta aataatgttt 2022721 caagcgggac tgtcacttct gatctatacc aggtttctcc ataaatttct gcttttgagg 2022781 cgacttcctg ctgatggtct tcgctgccga tcagtcccga aacaagcagc tgtccctttt 2022841 caacatgatc gtgtatggcg gccatgggct gtcctttttg cacaaacatt ctcgtaatgg 2022901 ttgctttctt tttggcgaca atattgcgcg ggctaacata tttttctttt tcgggctcat 2022961 ttttctccac aactttcata tgaatggtcg tccccttcag atcaactccg acccaagtga 2023021 tattgtctat tccattggtt aatgatttct gtattttttc gggcgacatc attaaaaact 2023081 gcagacggcc ctttttgacg ccgatttcat taagatgctg cctcatttga tgttctgttt 2023141 caggcttagc gcctgtcaca tcaattttcc acaccatatt ggacagcaaa aacaaaagaa 2023201 tgaaaaaaat cgcaaaaccg atcgtaaacc ctatattcag ctttgatttc agcaacagga 2023261 agggaaatcc cttccgattg ataaatcggg ctttacattt aaatttactt cttacccgcc 2023321 gaaaggcatg tacatcctga agctgtatat ataacgatac ggcttctttc ttttttttga 2023381 catgaaagac cggaatcccc tgtcttgtgc attcattaag gagccgctca atccctcttc 2023441 ccgtcaattc aagctggacc ttacccgaaa aaaaagacag ccatttattt ttcacaacat 2023501 ttccccctcg gctttatgac tcaacatatc gaacgacatc aatcgtaccc tccaaaagta 2023561 tctcttccgg aagaatcgcc ttgatgacaa aatttttacc agatatgatg cactggccct 2023621 gcttcagcat cagccgcact tcattctcac tgaaaagcaa aaggcctctg tggttttcta 2023681 tgtagatatg aagtctgcca accattgtaa tcctcggcag atccatcata acgtccgggg 2023741 gaatttccaa tgctcttgtc agccaagctt tcatacgatt ctttctttgc cccatacaaa 2023801 aagaaccccc tttcatctca tatgtatgat ttgaaaggag gttctaacac tttaattttt 2023861 acgggccggg cgcatcgtac ggtgaggttt tttcgcccgt ggaggtccga acacctctcc 2023921 tagaacgatc ccctgtacga cggtgtcttt attcacctga agcatttttt gttttgtgta 2023981 tactgttttt tgtttggcag cagcaagatc tcgttccagc cctttcaggt ttcttgctgt 2024041 ttccctgcgt ctttcttccg cttcccgtct tgcctgttcc atacggttag ggataggtgc 2024101 aggggcatct tcttttgact gcttcttttg aggagaagca gattgcacgt gttgaggttt 2024161 ttttcttttt tggctgtttt gcttttcttc tttgctcttt ttgccgaaaa tcgcagaaat 2024221 gattccgatg atcgctgcaa taataagcgg attggtcagt aaatcttcca tcagcgttct 2024281 cccttcttag agagattatg atttgcggtc ttcatccgaa gggtctttcg tcagcttgcc 2024341 gaatgaatca cgcatttctg tgtcagcatc gatgttcttg atattcatgt aatccatgac 2024401 gccaatattc ccttcacgca aagcttctgc catcgcaagc ggcacttccg cctcggcttc 2024461 tactactttc gcgcgcattt cttctacgcg ggcacgcatt tcctgttctt gagcgacagc 2024521 catcgcacgt cgttcttccg cttttgcctg cgcgatgttt ttatcagcct cggcctgatc 2024581 ggtttgtaaa attgccccga tgtttttgcc gatatctaca tctgcaatat caattgagag 2024641 aatttcaaac gcagttcctg agtccaatcc ttttccaagg actgtctgag aaatcatgtc 2024701 agggttttca agcacttttt tatgattatc agatgaaccg attgtagaaa cgattccctc 2024761 acctacacga gctacaatgg tttcttcccc tgctcccccg acgaggcgct cgatattcgc 2024821 tcttactgtg attctcgctt tcgctttcac ttcaatcccg tccattgcga cgccggcaat 2024881 gaacggtgtt tcaatcacct taggattaac gctcatttga acagcttcca acacgtcccg 2024941 gcctgcaaga tcaatggcag cacagcgctc gaatgtgagt tcaatgttag ctcgctgagc 2025001 ggcgataagc gcgttgacga ctctgtcaac attacctcca gccagatagt ggctttcaag 2025061 ctggtttgtt ccaacattaa gtcccgcttt atgcgcttta atcagcgggt taacaacccg 2025121 attcggaatg acgcggcgaa gcctcatccc aactagagtg aaaatgctga ttttcactcc 2025181 ggctgccaaa gctgaaatcc aaagcattac aggcacaaat gtaaaaaata ctgccaaaac 2025241 aatgatcgct actgcgacaa ttgccagaat cataagtgtt gacggatcca tataacttct 2025301 cctcgtttct atttaaattt ctctcacgac aatgcgtgag ccttctactt ttatcacttt 2025361 tactttttta tctttttctg taaacgatcc ctccgataca acgtcaaggc gttcatcatc 2025421 aataatcacg gtaccggaag gacgcagcgg tgtaaaggtt atacccactt ttcccattaa 2025481 gtccgtgcgc gtttgatttg aaacgtagcc gctctccgtg tttgtagaat catttaatat 2025541 caatttctta aagaatttca tacgctttcc caacaccctt gtcagtaaaa taaaagctgt 2025601 aatcgaaaca gctgaggcga tcaagagaga aaccgccatg acagtgaagc tccccgcggc 2025661 taaaaacagg ctcgcaataa tcgctcccaa gcccagtaat ccaatgattc ctccgggaag 2025721 aaaaatctca agcagaatga gaatcacccc tgctataaag aggagaaccg tctcataccc 2025781 ggcaaggccg gctgcaagat gcccgtaaaa gaacagcaat aacgcaatga gtccagccgt 2025841 tccagggagg ccgacacccg gggaaaaaag ctctaccgtc agacctaaaa aagcgattgt 2025901 cagcagaata gggacaatga ccggattcgt cagccatctt gccgtctttt ccgcaaagct 2025961 ctcctttgca tagctgatct gcgccttttc gaacccaagc ttctttacga gcgtggacaa 2026021 attgtcagca gtgccttctg aatagcctac ctcaatcgcc ttgtctgcgt taagtgtcag 2026081 cagatctccc ttaggcgcgc caacttcctt ggcatctata tctgggtcag ccattgcgag 2026141 cgcatatttt ggatcgcggt tatttttcac tgcggcatct tccatctctg ccagccaaag 2026201 tgattgagct ttttggtcag cggcattgcc ttggccatca acaatcgcgg cggctcccat 2026261 ttttccgcca ggcgccatat aaatgtgatc tgcttgaagt gcaatatatg caccagcaga 2026321 caacgcgcgt ttgttgacat atgcagttac ggggatctcg ctttcggtta tcaaatcggc 2026381 catatcaata gcagatttga ccaatccccc cggggtattg atatcaagaa taatatggtc 2026441 tgcatgtgca tcctttgcgt cttgtaacga acgggacaaa aacgaggcga gaccctgttc 2026501 gacatttttt tcaaccggga tcacataaac agtttgtttt tctgcttttg cgttcagctg 2026561 tacgcctaat aaagaaagta aaaatatacc caaaagagca gcacggaatc ctttgatttg 2026621 aagcaagggc ggtgtatccc tccttccttt tataataagt gccttctctt catacgtaac 2026681 aaatgtatca aaggtttcat ttttttatgt ataaaaaaag acatctctct tagaaagatg 2026741 tccttttctt tgccatttaa gacagttgac tgctcacaag cttattaatt aaacttccgt 2026801 cagctttacc ttttacttta ggcataattg cccccatcac tttgcccatg tccgcttttg 2026861 agctcgcacc gacctccgcg atggtttcat ttacgattgt acgcagctct tcttctgaca 2026921 gctgctcagg taaataaact tctaaaatgt ccagctcttt ttgaacttta tctactaaat 2026981 ctaaacgatt agcgtttgaa aattcctgga gggagtcttt acgttgctta agttcacgag 2027041 aaaggacagt gagttcctca tcctcggtca aactgtcttt cttaagctta attgcttcat 2027101 tttgaagtga agccttaacc attcgaacga cagtcagttt gtctttctca cggtttttca 2027161 tatacagctt catatcctgg ttgagacgct caagaagact cataaatcca ccctctttta 2027221 gaatttgcgt tttctagcag cttcagactt tttcttgcgc tttacgctag gtttttcata 2027281 aaattcacgc tttcttgctt cttgcaaagt acctgtcttt gatacactgc gtttgaagcg 2027341 acgaagagca tcttcaagcg attcgttttt tctaacgacc gtttttgaca ttctctttcc 2027401 ctccctccga atacaccaat cgactacctt taagttacac atataaacat gtactttgac 2027461 attataatat aagccatcag tcaggtcaac taagtgagtt cacttttccg tcatgagtgc 2027521 gactgcctgt ctatataatg aaagaaaggg gttggtgaat aggatgttaa ttctgattag 2027581 ctttactgct cttatattat tctttctcgc aggcatgaac atgcttcgaa agggcttaat 2027641 ttcaatggcg tactcaaaaa ttgaagaacg tttgctttta tttacagacc atccgttaaa 2027701 agcgtttctt atcagtattg tatttacggg gatacttcag agcagctcag cctttatggt 2027761 cattgtcatc ggctttgtaa gtgcgggcgt tctttctttt aagcggacga tcccgatgat 2027821 tctggggaca aatgttggct ctacttttac aactgaattt attgctatca aaatggatat 2027881 tgtgatttgg gttcttttaa taggaggttt attgtttttt ctgactggca ggtatccttt 2027941 gaaacagctg ggaacaagct tccttggact gggcatcatc ttcttttgca tcagcggatt 2028001 cagccatctt gccgggccgc tgacaaagct gaaaacgggc gccgacgttc tataccatgt 2028061 taacgattca aactggtccg ctttgctcat cggcatggtg ttaactgcca tcattcactc 2028121 cagttctgtc tgtatcggca ttttgatgag ttttatgaat gaagggatta tcggactgac 2028181 acaggcgatg agcgtcgtac tcggatcaaa tatcgggaca tgcattacag ctgtcatggc 2028241 tgctgtatcc ggcggatatg cggcgaaaca gacagcatat gcccatgtgg tatttaacgt 2028301 gctaggggtg gctctagtat tgccttttct gaccgcagcg accggctttg tagagcagtt 2028361 atcacctgat cccgcacaaa agatcgcgca tttcagcctt ttatttaatg tggtgacagc 2028421 tcttttattt cttccgctta caaacttgtt ttaccgattg attcaccttc ttatcccggc 2028481 taaataaaaa aatcggtaca ttttaatgca ccgatttttt aggttaagaa gacaaacgca 2028541 tgtgttcagt tatttcatcc tcaaccacac ggacaaactg tccttcgttg taaggataac 2028601 ctgcttttag gattttgact tttacgattt tgccgatcat atcttccgta cctttgaaaa 2028661 caaccttcat ataattgtct gtgtaaccga caaacatatt ttcttcttct gtttccttaa 2028721 acgcttcctc agggataatc tcaagcactt cattttcata ctgagaagcg tattcttttg 2028781 caagctggtc agaaagagca atcaggcggt gcacacgttc gtttttcacg ttttcatcca 2028841 cttggtcttc cattcgtgca gctggtgttc ctgtacgctt actgtaaggg aaaacatgca 2028901 gctcagagaa tttatgttct ttaataaagt tataggtttc cataaattct tcttctgttt 2028961 ctccagggaa cccgacgatg acatcagaag taacagctaa gcctggcagt gcttttttca 2029021 atttatttaa acggtctgca aagaattcca ttgtatattt gcgtctcatc cgtttaagca 2029081 ctgtgtttga tccggattgg ataggaatat gcaaatgatt cactatctta tctgagcggt 2029141 ctaagacctc gatcacttcg tcagtgattt ggctggcttc gattgaagaa attctgatcc 2029201 gtttcacgcc ttccacacgg gtgtctaatt cgctcaaaag cttcgcgaag ttgtaatctt 2029261 tcatatcttc gccgtagccg cctgtatgaa tacccgtaag aacaatttcc ttatatccgg 2029321 catcgacaag ctgctgcgct tgtttaatga cttcttcagg gtcgcgggag cggagcaggc 2029381 ctctcgccca cggaatgata cagaatgtgc agaaattatt gcagccctcc tgtattttca 2029441 atgacgctct tgtgcggtcc gtgaaagcag gcacatcaag ctcttcatat actcttgctt 2029501 tcatgatgtt gctgacgcca ttaatcggct ggcgttcttc tcggtattgg tcaatgtagc 2029561 caagcatttt ttcacggtcc tgtgttccga ctacaatgtc gacaccgggg atcgccataa 2029621 tctcagcagg tgaggtttgc gcgtagcagc ctgtgacaca gatgacaccg tcaggatttt 2029681 gacgaatggc gcgtctgatc acttggcggc tttttttatc tcccgtattt gtaaccgtac 2029741 atgtattaat gacatataca tcagctgttt gttcaaagtc tcttctttca tagcccgctt 2029801 ctttgaaaag ctgccagatt gcttctgttt cataatggtt gactttacag ccaagcgtat 2029861 ggaaagcaac agttgccatt actgatcacc tcttaataac tctgtttgat aagaaatcgc 2029921 actcaacgcg tatagcggag cggtttctgt ccttaaaatt ctcggtccaa ggccgcacgt 2029981 cacaccgtct tgctctgtga gccgttcaac ctccgcttct gttaaaccgc cttcgggacc 2030041 aaatacgatc aatagagatg atcctttcgg aaggctgctt acaatcgcgc tgaatgcgct 2030101 tatttcccct tgcttcgatg actcctcgta tgcaacgaca catttatcga aatcctgcat 2030161 cctttgaaga agctgctgaa aagaatggac atccatcact cgcggcactt cgttacggta 2030221 cgattgctca gccgcttcct tcgcaatttt cgtccatctt tcccgctttt tctttgcctt 2030281 tttgtcatcc agcttgacaa cagaacgcgc ggcttggaaa ggaataaagg catgagctcc 2030341 gagctcagtc cccttttgga taatccattc aagcttatct cctttcggaa ggccgctcgc 2030401 aatatagacc tttatcggaa gctctctgtt ttcattcgtc cattctatca caaggcagga 2030461 cactttatct ttggaaacag attgaagttc acattttgcc tcgaagccgt cttgagagca 2030521 gcagataatc tgatctccct cattcattct catcacgttc acaatatgat gaacttcttc 2030581 gccggtaatc gaaaaagtcg gcgcttcctc tatttgctgc ttcgtgagct cgataaaata 2030641 tcgttgcata cgctgtgaca cctactaact gttatttttt cgcaataatg ctgacccaat 2030701 cttccattga aaggatttct acaatggtaa agccagcttg ttccagtgct tcttttactt 2030761 cttgtttttt atgaccgatg attcctgacg taataaagtg accgccttct tttaacaggc 2030821 tgtacgcttg tgaagtaaag cgaagaatga cttcagccaa aatgttggcc acaatcacat 2030881 catgttcccc ttcaatcccg tctaacaaat tgttttgctt cacttgagca atatcgctga 2030941 ctttgttcag cttgagattg aggcgtgcac tttctacagc cacgggatca agatcgtagg 2031001 catgaaccga ttcagcctca agcattgcag ccgcaatact taaaattccc gaaccagtgc 2031061 cgacatcaat caccttatca cccttttgca caaagcgttc aagcgcctga atgcagagta 2031121 cggttgtcgg atgtgtccct gtgccgaaag ccattcccgg gtccatttca ataatcagtt 2031181 catcagtatg gaccggcgta tattcctccc acgtcggcac aattgtaaac ttttcagaaa 2031241 ttttcacagg atgataatac tttttccagg cagtcgccca ctcttcttca tttacttcag 2031301 aaatagtgat gtggtttctg cccaaatcaa tattgtaaag aaggagatta ttaatcgttt 2031361 ctttgatgcc gtctacagtt tcgcccagaa aactgttaac cggcagatat gctttgacaa 2031421 tgacaccctc atctgggtaa tcattggggt cgagctggta gatttccccg tacacattct 2031481 cacgttcttt aattaaatca agcgggtcct ctatcacaac cccacttgca ccagcttcat 2031541 gcaatatatt tgagataggt tcgaccgctt catgtgttgt gtgaatgctt aattcggacc 2031601 atttcaaaac taccaactcc tcatccaata attaatcgcc tttaaacgcg cgttttacct 2031661 tgtcaaagaa actcatttcc tgttcgtcag gcaggtttcc gctgacttcg gcaaattcgc 2031721 ggataatgtc tttttgttta tcagtcagat ttgtcggcgt aacgacgcgg acgacgatat 2031781 gctggtcacc ctgtccatag cctctgacat tttgaacgcc tttgcctctt aatctgaatt 2031841 tcgttcctgt ttgtgtaccg gccggaattt tcaatttcac ttttccatgc agcgtcggca 2031901 cttctacctc atctccaaga gcagcctgag caaacgttaa cggcatttca cagtaaatat 2031961 catcgccgtc acgctcgaag aactcgtgtg cgcgtacatg gaacacgaca aataaatccc 2032021 cggcagggcc gccgtttatt cctggttcac cctgtcccga gagacgaagc tgctgcccgt 2032081 catctacacc ggctggaatt gtcacattga ttttcttgcg ttttttgatt tttcctttgc 2032141 cgccgcagtc cgcacatttg tttttaatga ttttgcctgt accttcacag tggtggcaga 2032201 cccgtctgtt aacgactttt ccaaacggtg tattttgctc cacgtttaac tggccggagc 2032261 ctccgcagtg ggagcatgtt tctggatttg ttccaggttt cgcacctgag cctttacatg 2032321 tttcgcacgt ttcctcgcgg ggaatttcga tggttgtttc tttaccgaaa gccgcatcct 2032381 caaacgacag ggtcatcgta tactgtaaat cagcaccctg gcgcggagcg tttggatctc 2032441 ttcgtcttgt gcctccgccg aatatacttg agaaaatatc atcgaaacca aaaccgccga 2032501 aatcgccgcc gccaaaacct ccgccgccga agccttggtt agggtcagtg tgaccaaatt 2032561 gatcgtaatg cgcacgtttt tggtcatctg acagcgtttc gtatgcttct tttacctctt 2032621 taaatttttc atctgatccg gcttctttgt taatatcagg atgatatttt tttgacagct 2032681 tccgataagc ttttttaatt tcatcctttg aagcgctctt acttactccc agcacttcat 2032741 agtaatcacg cttactcatc tcgcttcact ctcccgaatt tctcacataa attagattgt 2032801 atcattttga attatgattt ttcaattcct tttatcccgg gcaagaaaaa aagtcaaagc 2032861 caagagatgc ctgactttga ctttctaatc attgaatcag attatgaaat gtgttctttt 2032921 cggtcagctc cggaagcggg gctgacacta aaaagaactt attttttgtt ttggtcgtcg 2032981 tttacttctt cgtattcagc gtcgacaacg ttgtcatccg ctttgccttc agcgtttgct 2033041 ccgccttgag cttgctgtgc tttagcagct tcttcataaa gcttcataga aagctcttga 2033101 acgattgttt gaagctcatc ttttttcgct ttgatctctt caaattcgtt tttctcaatc 2033161 gctgctttta aagcgtcttt ggcatcgttg gcttttttca cttgttcttc gtccactttg 2033221 ccttcaagat cttttaatgt tttctcagtt tggaaaacaa gctgatctgc ttcgttgcgg 2033281 acttcgattt cttctttttt cttcgcatca gcgtcagcat tttcttccgc ttcttttacc 2033341 atgcgttcga tctcttcatc tgagagacct gaagaagatt tgattgtaat gttttgttct 2033401 tttcctgtgc ctaagtcttt tgctcttacg tttacgatac cgtttttgtc aatatcgaaa 2033461 gaaacttcga tttgaggcac gccgcgcggt gctggcggga tatcagtaag ctggaagcgg 2033521 ccgagtgttt tgttgtcggc agacattggg cgctcacctt gaagaacatg gatatcaaca 2033581 gctgtttggt tatcagcagc agttgagaac acttgagatt tgcttgttgg gatcgtcgtg 2033641 ttgcggtcga tcagttttgt aaacacaccg cccattgttt cgataccgag agaaagcggt 2033701 gtaacgtcaa gaagaacaac atcttttacg tcacctgtga taacgccgcc ctgaatcgca 2033761 gcaccaagcg ctacaacttc atccgggttt acgcctttat gcgcttcttt tccagtttct 2033821 tttttgattg cttcttgtac ggcagggata cgagttgatc cgccgacaag gatgactttg 2033881 tcgatttcgc ttgcagaaag tcctgcatct tgaagcgctt gacggacagg acccattgtg 2033941 cgctctacta aatgagaaga aagctcttcg aatttagcgc gagttaatgt aagttcaagg 2034001 tgaagcggtc ctgcttctcc agctgtgata aacggtaaag aaatttgcgt agaagatacg 2034061 ccggaaagat cttttttcgc tttttcagct gcgtctttca aacgctgaag cgccattttg 2034121 tcttttgaca aatcaatgcc gttttctttt ttgaattcag acaccagatg atcgatgata 2034181 acttggtcaa aatcgtcccc acccagacgg ttgtcgccgg cagttgaacg aacttcgaat 2034241 acaccgtcgc caagctcaag gatggaaacg tcgaatgtac cgccgccaag gtcgtatact 2034301 aggatcgttt gatcttcatc tgttttatca agtccgtatg caagcgctgc tgcagtcggc 2034361 tcgttgatga tacgttctac ttcaagacct gcaattttac cagcgtcttt tgttgcttga 2034421 cgctcagcat cgttaaagta tgcaggaact gtgataactg cttttgatac tgtttcgcca 2034481 agatagcttt cagcgtatga tttaaggtgt tgaaggatga tagcagacac ttcttgtgga 2034541 gtgtaatcct ttccttcaat ttcaacttta taatcagtac ccatatgacg tttgatagac 2034601 ataattgtgt tagggtttgt aatagattgg cgtttagcca cttcccctac ttgacgttcg 2034661 ccgtttttaa atgcaacaac tgatggcgtt gtgcggtttc cttcagcgtt agcaataact 2034721 ttaggctcgc cgccttcaag cactgccaca catgagtttg ttgttcctaa gtcgattccg 2034781 ataactttac tcacttgaat aacctcctgc tatgtaatta ttgattcact ttgaccatgg 2034841 aagggcgaat gacgcgatcc ttcagcttat agcctttttg catttcctca acaacaatgt 2034901 tggagccgta gttttcgtct tcagcctgca taacagcttg gtgcagatta ggatcaaatt 2034961 cctgccctac agcttcgatg gcttcgacgc cttctttttt caaggcttct acgagctgac 2035021 ggtggaccat ttccattccc tggagcaaac ttttcgtctg ttcattgtcg gcttcaacct 2035081 gaagcgctcg ttcaaaactg tcaagagccg gcagcaaatc agtcacgata ttttgagaac 2035141 ggtatttttg ggacgcttcc atctctaaac ggctgcgtcg tttatagttt tcaaagtctg 2035201 cttgaacacg caaaagtttg ttttcttttt cctcaagcaa accttgcaat tcgttaattt 2035261 ggttttgaag aagttcgctt tcatttgttt cttcctgctg ttcatcagcg gcagcttgtt 2035321 cttcaatgat ttcttgctct tctgtttcgt tttgttcaac ggtttgtttt tcttctgaca 2035381 ttgtgttcac ctccctcaaa gtgtaaggag aaggacaggt gctgcccttc gataaaattt 2035441 gccaaaattc ccttattcat catacagact tgttaatgct tttgacaagt ccgaagtcac 2035501 atgctgaagc aggctgacaa ccctggaata attcatgcgg gtcgggccga taatcgcaat 2035561 tgagccgatc tgcttctggt ctacggaata agaagccgta atcagactgc aattttccat 2035621 ctcttcatag tcgttttctt ttccgatttt aatcgaaatt cccgtgtgcg gggattgaac 2035681 cagctttaaa acatcctgtt ctttctcaat taatgaaagc agcgaccgaa ctcgggtgat 2035741 atcatggaac tcaggctggt tcagcatatt gattttcccg ccaaaaaaca acttttcaac 2035801 gtgatttgtg gaatgaaagg ttgaacgaag cgcgtcgagt atattgtcat agtttttaat 2035861 gtgctgtctt aggtacatga caacttcttt aaatatgcgc tcattcagtt catccattgg 2035921 aacgccgctt aaacggtcgt tcagtatatt taccagtttt tcaatatcag acagatccat 2035981 tttggtcgga aagttaatcg ttttgttttc cacatgcccc gtattggtaa cgagaatcgc 2036041 taccgccata tcaggctgaa tcggaatgat ttgaatctgt ttaaggtaat tctcactcaa 2036101 cttcggcccg agtacgatgg atgtgtaatt cgtcagatcg gacaaaattt gcgctgattt 2036161 ttgaactgtc ttctccagct cgaaaatttt ctctttgaag atcgagtgga tttggtccag 2036221 gtcgcttttc gtcaatttga cgggtgacag caaatggtca acatagtacc gatacccttt 2036281 ttctgacgga acacgtcctg aggatgaatg ggttttttca ataaagccca attcctccaa 2036341 gtcagccatc tcgtttctta ttgttgcaga gctaaatgtg atttcatctt ttttcgaaag 2036401 agttcttgat cccaccggct gtgccgattt aataaaatcg ttgattataa cctgaaggat 2036461 cagcagctga cgatttgtta acatcatcat cacctctgtt agcactctca ataagcgagt 2036521 gctaattcta taacaaaagt atcaaaccac aagaaaaatg tcaattataa ctcacccaaa 2036581 aaagcgccaa aaacttcatt gcctaataat ttcccttgat gagtcaaata aacggcagac 2036641 tccgaattgt gaatcagccc tttttcagcg aggtctttta acacgcttgg gaaaagtcca 2036701 tccagggaac ggccgtattt ttctgcgaat cgttttttgc tgacaccggc tgtttttctc 2036761 aaacctaaaa acatttcttc ctcaatctgt tcttctgttg tcacttcatg tgtatctctg 2036821 tacggaaaac ccttttcagc tatcaggtca atgtaatgct taacaggtcc gacgttcact 2036881 gttcgtgtgc cgccaatata tccgtgagcg ccagctccga aaccgaaata ttgttcgttg 2036941 ctccaatacg ttagattgtg cttagattcc atgcctgcct tagcaaagtt gctgatttca 2037001 tattgatgaa tgccgtgagc ttccatcttg ctcatcacta tttcatacat ttcagcttcc 2037061 tgctcctgcg gcggaagatg aagccgccct ttttgcatca aattataaaa taccgttttc 2037121 ggttctacaa taagggagta aacggaataa tgctcagcgt ccaatgataa agcagtgttt 2037181 atggaatgtt ccagatgctt gagggtttgc cccggaagcc cgaacatgag atcaagactg 2037241 atattctcaa aaccgatttc ccgcgctctt tcaaaagagg tgaatacatc tttttgcttg 2037301 tgcactcggc cgattttttc taacagatcg tcttcgaacg tttgcacacc aaagctaagg 2037361 cgatttacgc ctgcttcttt taatattttt aatttctctg cggacaaatc gtccggattc 2037421 gcttcaaccg caaattccga taagtcgctt gagggcttta gcacgcggtt gatcatatcc 2037481 atcagctttt taagctgttc ctcagacagg gaggtcggcg tgcctcctcc gataaagatt 2037541 gttttgagat caggctgccc ggtttttgct attgtattta tcatttcctg ttcgagtgcg 2037601 tttaaatact cgtcgactgg ctgactttga ataaaatatt tattgaaatc gcagtagtgg 2037661 caaatatgct cacaaaatgg gatatggata taagctgatt tcaacggatt caccttcttt 2037721 acagaaagaa gccgcagtac aagactgcgg cggcttctat tgttttttcg gactgtcgtc 2037781 cattttcaga actgccataa atgcttcttg cggcacttca actgagccga cctgcttcat 2037841 acggcgcttt ccttcttttt gtttttcaag aagtttccgt ttacgcgaga tgtcccctcc 2037901 gtaacattta gccaatacgt ttttacgcat tgcttttatg gtggagcggg ccacgatttt 2037961 ctggccgatt gcggcttgta ccggaacttc aaactgctgg cgcggaatga gttctttcag 2038021 tttttcaacg atcacttttc cccgttcata tgcgtaatca cgatgcacga taaaggaaag 2038081 ggcatcgatt ttttcaccat tcagcataat gtccattttc acaagcttgg acggtttgta 2038141 gccgatcagt tcataatcaa aggacgcata gcctttagtg cttgatttca gctgatcaaa 2038201 aaactcatat acgatttccg ctaatggcat atcataaatg atgctgacac ggtttgcgtc 2038261 taaatactgc atatcaatga aattgccgcg ttttccttgg caaagctcca ttacagcgcc 2038321 gacatagtca ttcggcacca tcatcgtcgc ttttacgtat ggctcctcaa ccctttcgat 2038381 cttttgagga tccggcatgt tggacgggtt gtcgacaacg accttttcgc cgtctgtcat 2038441 atacacgtca tagataacgc ttggcgctgt cgtaatcagg tcgatgttga actcacgctc 2038501 aattcgctcc tgaatgatct ccatgtgaag catgcctaaa aatccgcagc ggaacccgaa 2038561 tccaagcgct tgcgaagttt ccgcttcata ttgaagggag gaatcattca gctcaagctt 2038621 ttcaagagct tcccttaaat cattatactt cgctgtatca atcggataca aaccacagta 2038681 caccatcggg tttagcttgc ggtatcccgg cagcgcttct tctgcaggat tggcagcgct 2038741 cgttattgta tcaccgacac gtgtgtcacc aacatttttg attgaggcag tcaggaagcc 2038801 tacatcaccg accgtcagtt catttgtcgg agttgctttc ggcgtgaaca cgcccacctc 2038861 tgttacttcg aattctttgc cggttgccat cattttgatt ttttgtcccg gctttaccgt 2038921 tccttcaacg actctgatat aagccacgac accgcggtag gcgtcataaa gcgagtcgaa 2038981 gatcagcgct ttgagcggcg cctccggatc tccggtcgga gctggcacct tttctacgat 2039041 ttgttctaaa atctcctcaa tcccgatacc ggcttttgct gaagcaagca cggcttctga 2039101 tgcgtcaagg ccgataacgt cttctacctc ttggcgcaca cgttcgggct cggcgctcgg 2039161 aaggtcgatt ttattgatga ccggaaggat ttcaagatcg ttgtcaagcg ctaagtagac 2039221 attggcgagc gtctgcgctt caatcccctg ggctgcatcc acgacaagaa tcgctccctc 2039281 gcaggcagca aggcttcggg atacttcata cgtgaagtcg acgtgtcccg gcgtatcgat 2039341 tagatgaaag atatattctt ctccgtcttt tgctttatat ttaagctgaa cagagtttaa 2039401 tttaatggtt atgccccgct cacgttcaag atccatagaa tcgagcaatt gttctttcat 2039461 ttctcgttga gtgattgccg acgttttttc taaaatacga tccgctaagg tcgattttcc 2039521 gtggtcaata tgggcaatga tagagaaatt ccgtattctc gattgcctct ctaaacgctt 2039581 ttctttatct gtcacaatct atcactccta ctattaaacg caaaatacac tagcttagat 2039641 tatatcaata ggattgtaaa gattcaatgt aaaacaagaa agagaaaagt tccctatcat 2039701 atctgggttg cttttctctt tcacgtactt attgattcat atcccgtatc cattcataca 2039761 ttgactgggc agtattggtt acggtgtccg aaagcgcttt tccggctttt gaaaacatat 2039821 tgaatgtctc caccttttcc agctcttttt gtttttctac taaatctttt gccgtgactg 2039881 tttctcctag gattgaggct tctttttcat tatcttttcc gtcggtgagc gtaaacgccc 2039941 ccttcagtga agggtcatga tagcctttca tactcagcat cccgtggttt gcctgctgca 2040001 tgccgaacag aacgcctaaa aacatgatcg tgacaagcag taagcacttt ccaaagtatg 2040061 caatcaaatc aaccacctat ttcttattgt tttttcgtct ccccgctcgc tgcgttgacc 2040121 ttttcagcat cccagtacat ttcgctgaat acgtccgcgg ccgcgttagc cgcacgctgc 2040181 agctcttcga gattattatc cactccgcca aactcgagca aaagcgctct atcggttaaa 2040241 tcctgattgt aaacaccatt atcgcctggc gagcctttgg aaaagacacc tgtgctaagt 2040301 ccggggtatt ttttctccat cagtttatga agctcactcg caattttata gttttcttcg 2040361 aagtttttgc tttttttccc gacgacaaag gctaccctgg catagctttt ccctttaatc 2040421 gttgcggttg tgtctttttt gcgccgagag tctctgtgga tgtcaatgat atattgcaga 2040481 tttttgtttg aagcgagggc gtctttcacg accggccttg attcatcata ggacctggca 2040541 tagtttaagc cttttttatt caattttgac tgtatatcgg ttttattcac tgtggctccg 2040601 attccctggg attcaagcgc ttgtccgaac atatctccta caagcgtgac attggcttta 2040661 gaatggcgcg ccatgtcagg atcggtctcg ccttttaata gagggagata tgattccgta 2040721 ttgtgcgtgt gatagataaa cacgaccttt ttatcacctg ttgtttgttt cggcggatct 2040781 ttttgcgcat tatctgattg cgtttgctgt ttttcaatct ctgccaaatt cgcttctctt 2040841 tcttcctcca tcaccttaga cggcggcggc gattccgcag gcatattcgt ataatccgtt 2040901 ccttgtccag ctaacaaaat ctcggtatca aattgtgcaa atcctggcag ctcccgaccg 2040961 agaaagctcc gcggatcttc gaggttaatg ctcgtcgcca gctttaaaga aagacgagaa 2041021 agatgaaatg agctgtctgt ttgagagagg tcagaagcga aataatggtt ttccatctgc 2041081 agcaaatgtg caaatacgtc acccggcaat tcttcagcaa tcccataaaa agagtcagac 2041141 gacggcctaa gttccggccg gagagacgtc agcacaccgg atagaacaaa aatcacgata 2041201 aggcttacga taaatagaaa gatggctttt accgctttcc ctccatttac cgcaacaaca 2041261 atctgtctgt ttctgcgttt atttctcatt gaatccctcc agcgcttgtc tagtaattac 2041321 tctatgaaca agctagagga agtagaactg tttagtgatt gtaggagcct ttgttttctt 2041381 gtgacacttt ttcatgaagc gctgtgttta atccgttcgc taaaacattt gccatatcgt 2041441 cgataaatga atcgacttcc ttcggtgtaa ccattaagtt gtgccctaaa ggcgaaagca 2041501 cctcgtgaat gagctgccgt ttttcatctt cttgaagggt tccgacaata cctaggaacg 2041561 attggcgctg cttttgatcg ggaagatcgt cttcagtgag cactttcttt ttcccaaacg 2041621 tcatgcctgc cggaacaagc gatcttgatg gcctgttatc cttcatttct ctgccaaaat 2041681 gttttaatat gtagtccacc gtgtcgctgg caattgtcac ggcatcaact actgtcggaa 2041741 caccgatagc aatcaccgga acaccaagcg tgtctttgct taaatctttt cgtttattcc 2041801 ccactccaga ccccgggtga atgcctgtat ccgatatttg aatggttgtg ttgacccttt 2041861 ccaccgcccg cgccgccaac gcatcaatgg cgatgacaaa atcaggcttc gattgctcaa 2041921 tcacaccttt aataatgtca cttgtttcga ttcctgttat ccccattaca cccggtgcaa 2041981 aagcactgac aggcctgtaa ccctcctgta cgttttccgg ctgaagctta aacaagtgcc 2042041 ttgttaccaa cagattttct actgccatcg gtccaagcgc atcaggtgtc acgttccagt 2042101 tgccgagccc aacgatcaaa cagctcgcat cttttgagat attaaggttt tcaagaaaag 2042161 ctgagaattc ctccgcaaag acagcagaga ccttctcctg catttccgaa tcattctccc 2042221 tgattccctg tgcttcaagc gttaaatagc gcccttcttt ttttcccgaa agctctgcgc 2042281 cttcctttgt aacatcaact gtgcggattt taatgccgcc gtgatcacgc tctttttcaa 2042341 taaagccttt aatttctttt gtcggcacag cctgctgatt ggccattgct tccttcgttt 2042401 ccactgccaa atcggtccgt atcaaatact gattcacatc cagctcactc tttttcatac 2042461 aggggcctcc ttcacattaa gtacctatat tgttgccatt tgctgaataa atcatgctaa 2042521 aaagagaacc ttcaatgaaa aatactttac atttatattg caatctaaag gtgtgtttga 2042581 tagaatacaa tttgttctat tgtgaagaag atttaacctt aagacactgt gctacaggtt 2042641 gtatcttagg aggtgaaaca catgccaaac attaaatcag cgattaaacg tacaaaaaca 2042701 aacaacgaac gccgcgttca taacgcgaca atcaaatctg ctatgcgtac tgcaatcaaa 2042761 caagttgaag cttctgttgc caacaacgaa gctgacaaag cgaaaactgc tcttactgaa 2042821 gcagctaaac gtattgataa agcagtgaaa acaggtcttg tacacaaaaa taccgcagct 2042881 cgatacaaat caagactagc gaaaaaagtg aacggacttt ctgcataata taaaaacgat 2042941 cctcaataat ggggatcgtt tttttcattt ctttttaaca gctgtaaaag gaacagttcg 2043001 agcaggagct gcttgtcctt tttcccggtt ttcatctcat agtccatgac ggcaagctgt 2043061 tcaataatta aacggagctc ctcctctgaa aaaagccttg cttgatccat cgccagcttt 2043121 acccgaaatg ggtgaacttt tagattagaa gcgatttgtt tttgtccgta tccctgttcc 2043181 gcgaagtact tcgtctgcag aatcagccgg aactgattcg aaataagcgc cataattttg 2043241 atcggttctt cattttgttt tagcaaatca taaaaaattt gcagactctc tgttcgtttt 2043301 cggttgacga ttttattgat cagctcaaaa atattttgtt caaggcttct agcaacaagc 2043361 atttttacat catccagcgt aatttcttca cgatctccaa taaacgtgca gagcttttga 2043421 atctcctgaa aaatcgatga cagatgaccg ttcacaagca gaaccaaatg ctccgccgct 2043481 tccgtgccga ttgttttctg ctctgttttt gcaaggttga cagtaaagtc tgtcgtttcc 2043541 tttgcattta attccttcgc ctccatcata aacgcgtgct tctttaacgc tttcgtcagc 2043601 ttttttcgct catcaagctt ttcatacgga gcaagcagga caaagactgt gtaaggcgca 2043661 ggtgattgta tatatgattc aagcgcactg acgttgtgct caattttttc ttttttcttt 2043721 tcacctgtta aaaaatatgg atttttcaca atgacaagac gccgctcccc cataaacgga 2043781 aacgtttcag catctgcaat cgcttgatcc agcgggtcct cttccagatc aaaaacggac 2043841 agattgaaat cctttgtctc ctgatcaacg accgtctgtc tgatcctgct gacggtttct 2043901 tgcagcagat atgtctcttt tccgtataaa caataaaccg gatggacctc tccttttttc 2043961 aggcttttcc acacatcaaa taccattgtt gtacgacttc ctctctttca tcatcccctt 2044021 ctatcctaaa ttgagtttgc aaaatagtaa agaggaagcc tgactgctgc ttccccattt 2044081 atattaaacg cctgttcgca agcccccggg acagcttgta aaaaggcgat aatcaccaga 2044141 acagaaaacg ttaccttagc ttctagattt ttcaaaacaa ttccattata cttaagtcag 2044201 tcaggaggga taaagttgaa tgattttgaa aaaaacgttc aaagcaaacg aaatgatgct 2044261 gtagattcag ctgttggttt tgttgtgtcc ttcggatttt tcgccttctt gtttgtcatg 2044321 gcaacggtta ttcacctagt tggttcataa cagcgactgc ccgggctgct gatttctcgg 2044381 cagtcttttt tagttcgtct ctgttatatc tgatgtatca tatggaggat agacagaaaa 2044441 ggttccaact ctgtttttgt atctatattg gatcgttccg ttttgatctg ttcgcagcac 2044501 gcggatagaa tgtctctgta atagttgcag aactttttga tgaggatgat ggtaccgatt 2044561 gtttttcccg gctgagataa tggccgtttt cggctgaagc tgttggatga attcttcacc 2044621 ggtagagcct ttgctcccat ggtgccccac ctttaacaca tctgctttta tattcggaaa 2044681 cacgttcatc acctcttgtt ccccttcttt ctccagatca cccgtcaaga tccagctcat 2044741 accgcccgtc tccatccaca gaacgagaga tgaattattt ttgcttgccg gatcaggtgc 2044801 ttccggtgac agtacatgga actgcaaatc ctttatttgc aacacatcgc ctcgcttcac 2044861 ctcttcaatt gccactccct cttccctggc tgcctgcagc actttctcat ctttaggttc 2044921 agaaacgaac cctttcggaa tcacgaggcg ctttacttta tgatgcttca gcagaatctc 2044981 cgcctctccg atatgatctt ggtcagcgtg cgtcagaatt aaagcgtcaa gctgcttgat 2045041 tcccttagca gttaaaaacg gaatcagcac cttttccccc agtgaaaacg gatgctgttt 2045101 ttcgcgccaa ggctctgacg agtaagacaa agtgccgccg gtatcaatta agacacgacc 2045161 ccgctgatgc ggagcaccta caaacatgct gtcaccctgt ccaatatcta tcatatccac 2045221 ttctccttcg gaactaagac acggatatat aaagagcaga aacatcaccg tgcagcaaat 2045281 gcctccggtt accatcaact gcgacaagga gcgtttttca atcgccataa gcaataggat 2045341 gatcgtgact gtgaataaaa aaagcaaaac aggtgcagga tgtgcgatca taatcgtgaa 2045401 cacatcaaca tctgcaatgt ttgtgattaa cctattgatc cagcttatca ataaatcaaa 2045461 ccagctgaaa aacaatctcc caaacgaagc ggaaagactt aatagaagaa cacctgctac 2045521 agctcccggc aaaatacaga aggtataaaa tggtaccatc aacatattca tcggtacgct 2045581 gatgatagaa aactgatgaa aatgatatag gagaatcgga agcgagccca gctgagcgat 2045641 gagtgataca attgtcagct gccccaagga ggttttaacc tgctgaaaaa tagaagagga 2045701 tagaattaaa gaaaaactga cggcgaacga tagctgaaaa ccggcttcaa agagatgata 2045761 aggattgaag agcagaagga cgatgtacga aaggcaaatt gcagttgcag agcggacacg 2045821 ccatttgaca agacttccag ctaagtaaac acccgacatg agagcggcgc gtagcactga 2045881 aggagcagcg ccggtcaaca tcacatagag cggcagaaat aacagcaaca gaattgacgc 2045941 cttttctcta gttataccaa ggcggatcat gatataaaac aaacctgctg tcaaaatccc 2046001 cacgtggagt cctgatattg ccaagagatg gacaacacca agcttttgat acgcggtaag 2046061 cacttcatcc tccacgtaaa atctgtcacc aactgtaagt gcctgtacaa tccctgtcga 2046121 atcaggaggc agaaggctgt ttgtgaatga tatgatatgt tttctcaagc tgagcacctt 2046181 gtacttgaaa ttttcaggtt cgctgcagtt ttggatagac gtgacagagt agttccaatg 2046241 aatatgctgc cgataaagat actcgttata atcaaatgca cccggcacag ttgcgtgatt 2046301 cggttcttcc aatgtaccag tcaactcaca tgacattcct ggttctatgt ataacagctg 2046361 ttctttttca ccagcagact gaatgcgata cgcagcagcc catttttcct tatcaggtgt 2046421 ctcaaccatc atagacatac ggtcgccgtc aattttggga atagtgtcaa tcactgcctt 2046481 gaattgatag gttccctgcc gataggaaga gacattctga gaatctgtga ctgcatacag 2046541 tacaaaaaac aatataaaag agaagaaaca aacaataata agaaaagcgt gcctcgtttt 2046601 gattaaaatg atgaggagaa agaggatgaa aagaaaaata gcggggaaat aagcggcggc 2046661 agtaattcca gccgttgccg aagctgccgc cataggcaat aataagcgcg aattacgcat 2046721 tcatcacacg tagctcgtga aaagtgtatt cgcctgttca tgtatctttt tcaattcttc 2046781 ctccgctaaa ccggcatcag ccaatttccc tattagaccc gctacaaatg aaagcttttc 2046841 tctgtttttc agatcaacga tcatttcatc gagttcaacc tgttcaacag ttacacccgc 2046901 ctgttcaaat aattcctgcg catacggatg tgttttgtaa tcctcagcat aataaaccgt 2046961 tttgatacca gcttgaataa tagatttgca gcattgaatg cacggataat gcgtcacata 2047021 aatctcggct ccatcagtcg gcaccccaaa cttagagcat tgaagaatcg cattcatttc 2047081 agcgtgaatg gttcttgcgc aatgatcatc tatcattaag catccttcat ctgcacaatg 2047141 tacgccgccc gcgattgacc cattgtagcc tcctgctatc atgcgtttgt ctctgactat 2047201 agtagcgccg acagataatc tcggacatgt gctgcgcagc gccaataaat ggctttgagc 2047261 cataaagtat tgattccatg aaattcgttc cacgttgttc cctccaaatg ttgtgttgcc 2047321 tgacctttag tttacctatc ataatgcatg accgtcaaat cactttactg taatggaaga 2047381 ctttattttc tcaaatgact tttcacctat tcctgaaacc ttagtgatat cttcaattgt 2047441 ttggaaacga ccgttttcct cccggtatgc aataatagct tcagctttgg atggccccac 2047501 ccctgagatg ccttgtaact cctctaaggt tgctgtattg atattcacca gcgctccctt 2047561 ccctccatcg ctttggacag accctccgcc accttgctgc actgctgttt cctctccctt 2047621 tttcgggatg tacaccactg tcccgtcctg cagaatctcc gccaaattta cttgcgcttc 2047681 gtctgcttgt tcactggtcc cgcccgcttt ctcaattgcc tgagatactc tgtcccctgt 2047741 tcgcatttca taaacgccag gatgctgaac agcacctttg atgtctatca caattgtttc 2047801 gtttgactcg tcgttgtttg cttcctgctt taccactgta ttttctgtct ctgttggtac 2047861 agcttgcttc accggctctt tatttttccc tgtggccaga aagatcataa tcgctgtgaa 2047921 aacagccgca gaagccgcta aaataattgc tttcttatgc tgattcaacc aattcatcgt 2047981 gcatgttccc cgctttcgtc atattttatt ttcataacac atatggttta gaggataata 2048041 gctcaaagga ggggaaacca ttgaagatag gctttatcgg cacaggaaat atgggtacga 2048101 tccttatcga atcatttatt gaatcaaaag cggccgatcc ctcaaacatg acaatcacaa 2048161 accgcacaat tgaaaaagcg ttgcacataa aaaaccgcta caacagcata aacgttaccg 2048221 aaagtctcga aaagctcgtt tctgaaaacg agatgatttt tatttgtgtt aagccgcttg 2048281 atatatatcc tttactggca agagcgttac cttatttaag aaaagatcat attctcattt 2048341 caattacaag ccccgttcaa accgaacagc tcgaacaata tgtgccgtgt caagtggcgc 2048401 gagtgatccc aagtattacg aacagagcgc tggcaggtgt ttctctcgtc actttcggca 2048461 caagctgcgg cgaatctgca aaagcgaaaa tcaatgagct gatgcagcat atctctcatc 2048521 cgctgcaaat tgaaagtgac atcacgaggg ttgcatcaga catcgtaagc tgcggccccg 2048581 cttttatgag ctatctgatt cagcggttta tagatgcagc tgtttcggaa acatcagtgt 2048641 ctaaacagga cgcgattttg atgtgtaagg aaatgcttgt cggaatggga aaactgttag 2048701 aaaccgaatt gtataccctg cctgcattac aggaaaaggt ttgcgttaaa ggcggtgtaa 2048761 caggagaagg cattaaagcg ctggaaagcg gtgtgcagga tatgtttcac cgggtatttc 2048821 aaaatactca tatgaagtac gaggaggata tttccgcagt gaaaaagcag tttcatgtgt 2048881 agacgagtat gtcatacgtt cgtctgtact gcaaaagcat aaaaaagcat tttaaaaaac 2048941 catcgtttta ggaaacgatg gtttttgatt tctgcgcctt gaaaaagagg cgttctgatt 2049001 gtgctgatgg ctcggtatcc gtaaaatcag ctgtcacgcg atggagctga aagccgcagt 2049061 tcttaagcat ttcttcgtat tcttccaccg ggaacgttct ttgctcgtgt gtctcatcaa 2049121 aacgatcata cgcttctccg ttccacacaa aaaacgacat atcatgaatg acagaaagct 2049181 cgtcacttcc ggcaaagctc tgccaaatat agctgatatc ttcgtcctgg tcagcaaatg 2049241 tgctatccgg aaagacttcc gcaattttaa aagatgaatg aacatcaaac agcaggatgc 2049301 cttcaggctt taatacccga aaaacacttt taaaggtttc gatcacatca ttttttgttt 2049361 ttaaataatt taatgagtca cagcatatca caacagcgtc aaattgaccg tcaaagccgg 2049421 taatctctct catatcctgc tgaagaaata aaataggctg gctactcgat accttttgct 2049481 gggcgaaaga aagcatctct tcgctgagat cgatgcctgt aacctcgaag cctttttcgg 2049541 caagccggat ggagatttcc cccgtgccgc atgccagatc gagaatacgg cctttttccg 2049601 ggagagatgc ttcaatccat tttgtccatt gatcgtaagg cgcgtgtgac attagctcgt 2049661 catacacgct tgcaaagcct tgataaatca ttgattcatt ccaaagtcaa gatctgcgag 2049721 cggagcgtct ccccacagct tttcaaggtt gtagtagctt ctttcatcct tgtggaagac 2049781 atggacaact acatcgccta gatcaacgag aacccatctt gcttcatcaa agccttccat 2049841 ctttttgact tgaatgccgt tttcatcagc ttgatccttg atttcacggg caatcgcctg 2049901 tacctgttta tctgaatttc cgtggcagat cagaaaataa tcagcaacca gagaaatacc 2049961 ttccatatcc agtgctaaaa tatcctctgc ccgtttatca tcgcaagccg cagctgcgat 2050021 ctttaaaatg gacttttggt tcattcacaa attcctcctg ttcagctgcc agacacaagc 2050081 cagttatacg ttaaaaatgt gtctggaaaa accggttgat tttttttcat aagaaaaacc 2050141 attgtatttt taatggactg aatcagcgct tgattcaaat ctgtctcagc aagcttacgc 2050201 acctcatcga caccgggaaa tgcccggttt ggctcaatgt aatcggcaac gtaaatgact 2050261 ttttctaaaa gtgtcatgcc ggggcggcct gaggtatgat acctaatggc gtcaagaatg 2050321 tcttcatctt gaacccctgc ctctctttgg accaaataag cgccgaccgg agcgtgccag 2050381 agctccggat tatgatccaa taaatgcgca ggcatttttt cacgcgcaat aatttgtttc 2050441 atttcttctt tcgggcggaa tttggcgtaa tcatgaaaga ttgccgctat ttccgctttt 2050501 ttagaatcgg ctccaaaacg ctccgcaagt tcgatcgccg tgttcatcac gccaaccgta 2050561 tggatatatc ggtgttcggt caattgctgc ttcacgcatg caagtgcctc ctcacgattc 2050621 atataaacca ttctcctcta catacttctt cactttatca gggattaagt agtcagtggg 2050681 cttcttgctt ttaaaccgtt cccttatcat agttgatgat acctcaaatt ccggaacgtc 2050741 tgcaaagaga agcggataag gggtttcaac atgaaaaccg gggcgcttta ctccaataaa 2050801 ttgaatgagg ttcagcagct cgtccagctt ataccatttc ggcaaatatt caatcatatc 2050861 agcgccgata ataaagaaca gctgatcatt tggataacgc tgcttcagta aagaaacggt 2050921 atcaaaggta tatgatggcc cttctctttc catttcaaca agctccagct taaaggacgg 2050981 attagattga attgcaagct ttagcatttc cacgcgatga aagctgtcgg tatagtcttc 2051041 gttctgttta tgcggcggaa tttgattagg cataaaccaa atttcatcaa gccccgcctg 2051101 gtacagcacc tcattcgcca ttaagaggtg accattatgc ggagggtcaa acgtgcctcc 2051161 gaaaattccg attttcttca tttcaaccac ctttaaggaa gctcgatttg tttattttcc 2051221 tttgattcct tatataacac aatcgtattg ccgattgtct gcaccaattg agagcggctt 2051281 ccttttacaa gagcttccgc tacatcgttt ttatcctctt cgcaattctg aagcacgctg 2051341 actttaatca gctctctcgc ttcaagcgcc tcagcaattt gtttaatcat gttgtcgttt 2051401 actccgcctt tacctacttg aaaaatcggc gttaaatgat gcgcttttga acgcaaaaaa 2051461 cgtttttgtt tacctgttaa cattctgttc ctcctaattt tcctattaca atagatctca 2051521 ttttttcaat attaggctct tgtccagtcc acaattggaa agacaatgct gcctgttcaa 2051581 caaacatgcc cacaccatcg agtgttttca agcctttttg gcttgcttct tttaaaagtg 2051641 ccgtctgtat tggattatac acgatatcac atacgacggc actgctcgcg gcacgctgta 2051701 atgaaagcgg cacatcgtcc acgttcggat acatgcccac agacgttgta tggatgataa 2051761 catcatactg ctcaagacgt tcttctgctt cttttatgct taatacttct ttattgtgaa 2051821 acgagggagt agcttctgta agccgctttg ctttttctaa cgtccggttg caaatgtcaa 2051881 attttttcgg ggtatttcgg acaattgttg taaaaatggc tctcgccgct ccgccagcgc 2051941 cgatcattaa gaatgacagt tcagagatgg gcttgtctaa taccttcatt aatgacttca 2052001 cgaagccttc cccatcggta ttgtatccga caagcttatc tccctctctt ctgaccgtgt 2052061 ttacggcacc gagcactttt gcactctcat caatatgatc caaataatcc ataatggaaa 2052121 ccttgtgcgg aacagtcaca ttgattcctt gtacgcctag agctcttatt ccttttaccg 2052181 catcctccag atcattctct tctaccttga aggcatgata atgtccgtca agcccgaggt 2052241 ctttcaatga tgcgttatga atatcaggtg acatagaatg gccaatagga tttccgataa 2052301 ccccgtacag ctttttcata cacctctccc cttttcttaa attaatgaac gccgaacaaa 2052361 tacatgaacg ccttttggcg cgtatgcagt taccttttta tcagcgtcat ggacagtaac 2052421 ccagcctaac ccagagaaaa cgatatctgt ctttttgtct tttatcgtaa acgtatgggc 2052481 gaccaattca ggaaactcat ccatttcatc tttacccgga ggtgtgagca attcccctgc 2052541 atgcttttca taaagcgcgt ctgcattttc aagttttgtt ctatgaatca tcagctcatt 2052601 cggcatatag caaataaaag gagatctttc cccagacaca taatcaaacc ttgcaagtcc 2052661 gccaaaatac agtgtttgct gatcattaag ctggaatgtg cgaggcttca gctccttttt 2052721 aggagataat attttcaggt cctttttatt gacataatgc gccatttgat ggttgttgat 2052781 aattcccggt gtatcataaa gcgatgaacc gtcatccagc gggatttcaa tcgcatcaag 2052841 ggttgtgcca ggaaattggg atgttgtaat aatatcttct tcacctgaca cttctttaat 2052901 aatccggtta ataaaggttg actttcctac atttgtacat ccgacaacat agacgtcttt 2052961 tccgttgcgg taatgctcaa tcgcgtcaat tacttctctg attccctggc cgcgacccgc 2053021 actgaccaaa aatacgtcaa ccggttttaa gccaagctct ttcgcttcac gcttcatcca 2053081 ttggatcaga cgctctcttt tcagtgactt aggcaaaata tccgctttat tgccaactaa 2053141 taagataggg tttcccccca ccaagcgctg cagcccatta atccagctgc cgttaaaatc 2053201 aaaaatatca acaattttta cgaccagaga gtccgtttct ccaataccgt gaagaatgtt 2053261 caaaaaatca tcatcagtta aggagacatc ttgtatttca ttatagtttt tcagtctgaa 2053321 gcaacgctgg caaatcacat tttctttcgt aagcgatgca ggcggcgcgt accccaaacc 2053381 tgttttgtcc tcggtttgga tcgtaactcc gcacccgata caaacaacct tttccatttc 2053441 ttactcctcc cactgaatgt gcccttttcg tttgagagca ctcagtattc tgcgttcgac 2053501 ctggcggtta aagcgcgtaa tgaatccgtc agaggaagcg actggcacga ccaaaatcgt 2053561 atggtagccg tttcggtttc ccccgagtac atcggtcagc agctggtctc cgatgacaac 2053621 gcagtcctct tttttcagct ccatattgcg caccgctcta ttaaaggctt tacccatcgg 2053681 ttttcttgct ttatagatga atgggattcc aagcggttct gagaaaagtt tcactcttct 2053741 ttcgttatta ttagagacaa ttgtcacttt aatgccgtgt tccttcattt cttcaaacca 2053801 ctcgatcaat cgcggcgtcg cgttcggcct gtcccattca acaagcgtat tatccaggtc 2053861 agtaataatt ccttttacat ttcgttcctt taatttctca ggtgtaatat gaaaaatatt 2053921 ttttacaaac tcgtcaggta aaaaaaactt ttttaacaaa acccgcaccc ttcccttttt 2053981 ctttctttca aaatgattgt cgaaaaaaat cgaacttgcg cctaaagaaa aactgagcaa 2054041 aaaaatttcg acaaaaattg ggtttcttca ccaggtgtgg ataaatttac acacactatc 2054101 cactcttatt acatcactct ttagacaaat tataaacacg atactcacaa gttatccact 2054161 ttttggtgtg gataacagaa cgattgttct tatatgcatt tcatggtaga ttaaagataa 2054221 cttcaacctc agatgaatgc aacttatcat tgtatgcgtt aaaatcatga atgattccaa 2054281 cttttaagga ggtgcctctc ccattaattg ggttcctagc atgagaaaac tgtctgatga 2054341 attactaata gaatcttatt tcaaagccac cgaaatgaat ttaaaccgtg actttattga 2054401 gttaattgaa aacgaaataa aaagaagatc gctcggacat attatttccg tatcttctta 2054461 ataggaattt gtctattttt tccgggcgta tttccttttt ttactcagat gactgatatt 2054521 atatcacttt ggctgcgcgc tttactacta ttttcagcaa aaaacacccc taaaaagagg 2054581 tgttttaaag ggccggttat tatgctaacc agtatatgcc gcccacaaca aggagaacaa 2054641 caactaaaac aacaataaaa gcgtatccat atgctctgcc tgcgccatac atgtgaagcg 2054701 cctccttaat aaggttttat aacagcctat gtaggagaaa taaatcggac taggcggttg 2054761 tccggctcaa cgctgcagga tctgccccgc gaactaattt attaatgttc aacaacagaa 2054821 tttcgtctat tggcaataaa gaatccacaa atcattgcaa gaatggccat cgcccaccag 2054881 aacgttgaga tcgcctgatc atgatcgatg ataatcaaac gaatgacagc tgtgatgcca 2054941 atataaatga agtagcgaag cggaaaatga aagtctgatt tgaagtattt gataatcaaa 2055001 gcaatgaact caaagtacat gaagaatata agcagttctc caagcatctc ataatagctg 2055061 tccactttgt tgaacagtga cttgtatacg aatagcacaa tgtaccaagt ctcgctgatc 2055121 agaagtgcgc ttaaggctaa cgccagaaag aacagacaga cgttgagaag cgcttgtaac 2055181 aggtaaggca cctttttgaa tttgttagaa aatctcatca tgttgtctcc tatttcaata 2055241 tattcgtggt ttttattctc agcctacatc ttggtgttcc aaaatcgtag cacaatgtag 2055301 tacttagaat tcttttgtat actgtgaaac tgtccctgca tgcgggacat cattcgcgca 2055361 atgcttcttt caccgagtcc gttgctttcc ggtgttatat ctgcaagttt aatcgtattg 2055421 ctaacatgga tctcaaatat ctcttgatcc gatacaaacg tgatactgat tttttcttcc 2055481 ggatctgcgt atttcaataa gtttgacatc acattatcaa atacacgacc aagctcctcc 2055541 aaattcacgt taatataggt ttccggcagc tcgcctgaaa tatggacccg aaaatgctcc 2055601 tgatgaagga tagcaatctg atctgatatt agatcgtaga tcacttcttt cactgcaacg 2055661 gtctccagat cggcctcata ttccttgttc agcaggaaat acgcaaacag attgtcagac 2055721 aagcttttta attgcagtgc tttaccataa gcattggcta cataccgatc tttgctggca 2055781 cccgcttcgc ctccctcttt tttggcaaac tccagattca tgatcagcga cgtcagcggt 2055841 gtgcgcatat cgtgcgacat ttcggtaacc aggctgcggc tctcagcttg caattcctcg 2055901 atagctttaa gtttatccag gaaagctttc cgcagatcct caatgctctt tgcaatcatc 2055961 gctaattcat catgcccttt tatcgtcatc tcgtagtcca gttcgccccc ttcaagaata 2056021 tgaatctctt gatgaatcgt tttaaggtag cgaagacttt ggcgaattcc gaagagaaca 2056081 atgattaaaa agatgagggt tgccccgagc aaatccaatg caaaggccag atcataatat 2056141 cgggaagagt agaaaccgtc gataatgact cgtccttcac catcgctaaa cttgacagga 2056201 tgtgaatgat tttgagcgta ctgagtcagc ttttcctttc cataatccga ttcggaataa 2056261 atagaatcat attgcagctc ctgatccttg aatatggtga ggttaatgta attttctttt 2056321 ttgacccact cgccaaacgc ttttctatct gatgtagaca actcattttc tgaaacgtac 2056381 ttgctgaatt tttgaatgta tcttgctgac tcctcgtgat aatactcttc cgaactcaga 2056441 tatccctcga tcagatcatc tgtgatcttt tgcaacgtca gaaagatcac accactcaca 2056501 atcgcagcaa ccattatcag caaagccagt tttttggtta gcgtaaattt aagatgcgcc 2056561 aaatcgatat cctcttcccc attcagtttt tatataaacc ggacgtgccg gatcatcctc 2056621 aattttggag cgcagcttcc gtatatgcac catcaccgta ttgttggaac agtaaaagta 2056681 aggctgtccc cacacactct catatatatt ttgggcagaa aatattttgt tgcgtttgtt 2056741 catcagaagt ttcaggatac gatactccag atctgacaac ttgatttgct tctcctcttt 2056801 ccacacctca ttaaattctt cgctcactct tagtttgccc ccgataagaa atgtttcttc 2056861 ctgttccttc ttttcctgat agatagtata tctgcgtaat tgagcaatca ctctagcgtg 2056921 aagttcctct tccgagaatg gtttagtcat ataatcatcg ccgccggcga gtaatccctc 2056981 agttttatcg agtgtactcg atctggccgt cagaaacaga atcgggacgt tagaggattt 2057041 cctgatgtgc tgacatgttt caattcccga aatgcctggc atcataatat ccaaaataac 2057101 caaatcaagc gagtcattca caagttgcaa tgctcgcttt ccatccttgg ctcttagcac 2057161 ctcgtaacct gcacgtgtaa gggattcctc caaaagatca ccaatatcct catcatcctc 2057221 tacgactaat attcgatagg ccatgtctct ctcacctcat gattcttgtt gttatttctc 2057281 gtgtgtcctt actatatatc gttcatagta ataagtacgt tataagatac tacgtaaatc 2057341 ttaacaattt atgaaagctg atgctcgcca caaatttgtc acattttcta aaaaaaatga 2057401 tgactcttca taaattgtta agattcggtc tttatattta tccattgtaa ggctcaagtt 2057461 tttcagatcc gcactacaca ttgccgtgat aaatgggaaa ggagtattga tatgattgta 2057521 caaaaagaag gacgcgggca accggtgagt ctgcgggaac gggttcattt tctggacatc 2057581 gtacgaggat ttgccttgct tggcattatt attgtcaatt attttctgat cgtagattca 2057641 gtaaagggat tcgaaatggc ctccgatgac gtactgcata agctggtttc ctggtttgcc 2057701 gaagggaaat tcgttacgtt attctccttc ctgttcggag tcgggtttat gatctttatg 2057761 gatcgagccg cgcagaaggt agagagtccc aacaagctgt ttgcccgcag gttatctatc 2057821 ctgttgggat ttggcatttt gcacatcaca tttgtttggg tcggtgacat attggccttt 2057881 tacgccgtaa gtggcttcct gttactcgcc ttctataaac gcacggccaa aacggtgctt 2057941 agatggatta tcgcacttat cgtgtttcaa ttcctgactc ctgttttcac aatgttgtac 2058001 aatgtcatca atactgcagg gtcaaaaaac ccgaattttt cagagtttac tttgtttagc 2058061 cacagcagcc ttacctacat ggaatccatc agcactcggt ggacagatat ggtcacgatg 2058121 gctgccggct ctttctctat gatctattcc atgtttctca tgtttctgct gggcgtgtac 2058181 tttgttaaga tggaattttt caaagacatg gaagcgaaaa agcctatatg gaagcgtatc 2058241 tggatcatta gcacaatcgc ttttctaata acacaaagca gtatattact agacatgttt 2058301 aatctttctg agaatatgct gtggaaggac atttcctctg tcttgggtca aaatggcggc 2058361 ttaaccggaa gtatgtttta tatgagcact tttgcaatgc tgtttctata ccttcctcag 2058421 ctgcgaggcc ctatgatgat attcaccaaa gtcggacgga tgtcattgac ctgttatctg 2058481 cttcactcta tcattggaac agttctgttc ctcaggtacg gattcgggct tgcggatcat 2058541 attcaatccg ccggcacgtt catgttcagt ctggccgtgt acttcgttct tatgagcttt 2058601 agtacattgt ggttgaaacg gtttaggtac ggtccgatgg aattagtatg gcgcaagctg 2058661 acgtacggca aagtaaacgg gagtcccaaa gcaactccgc tgcattcgga aaaatctatt 2058721 cagaaataac ccccttgcac agattgcatg acttcaaatt agtgttgttg aatgaagcgg 2058781 gcattaaacg gacagatttg atatatggac tagttatttt tatatcattt aggcttcttt 2058841 gggctaataa atccaccaga gtttactcaa tgtgcattgc tcatgatcga atctaaattg 2058901 aatcttttac gcatgttcat agtcaaaggc gcctcattcg actatttttg taacttttcg 2058961 caggaaaaat tcgagaatga tgacaaatcc cgcatacgac acttaatacg gtagtgaaca 2059021 atagtaaatt agggttacat gcagcttgtt ttccaatgaa acaaagaaaa agaatcatac 2059081 aaaaagacag gagaaagctt ttgaagtatt ttaacgccaa atttaccgcg gaagaaagag 2059141 cgatggaatc acttttttgt gaaaaggcct cgcagagcag ctcgaatgtt ttactgaacg 2059201 actgaactct atattttagc aactgaggga gtgaacaatc atgaaaacta aaaatgaacc 2059261 aaaagttatt ctggaactag caaaggaatc tgatctgcca gaattccaaa aaaaattaca 2059321 agaagccttt gcgatcgccg tgattgaaac gttcggtgat tgcgaagatg ggccgattcc 2059381 atcggacaat gatgttcagg agtctttcaa tgctcccgga gcagtggtat atcatattct 2059441 tcaggatggt aagaatgtcg gtggtgcagt agtacgtatc aacagccaaa caaatcataa 2059501 ttcgctagat ttattctatg tatctccaga atatcacagc caagggattg gtctttctgc 2059561 ttggaaagcc attgaagcac agtatccgga tactgtgctt tgggaaaccg tgacacctta 2059621 tttcgaaaag cgaaatatca acttctatgt gaataagtgt ggatttcata tcgtagagtt 2059681 ctacaatgaa catcactcta atccgcatat gcatcgcaat ggacgtgaag atgacaagcc 2059741 cctactgaat gatgatgact ttttcagatt tgtaaagatt atgaaaaaaa aggactaaac 2059801 aattgaacac ggcgagatgc cgcagagagt tgctggtaac ttttttatat ttcattatca 2059861 gaggaaggta ataatgatgt ttaaaaggtg ttttgatccc tgtctcataa acaggggtca 2059921 aaacaccttt gaatcatcgg tttcttttct gacatatacc acgcccacta gtccctcaac 2059981 atagtaaaaa catatcatga gttacaaaag cttttattca aagcatatgt ttattttatt 2060041 tatacttatt ttcatcattt ttcagaattc tggacacaaa tcgggtacct attagaggcc 2060101 aaggaactct acatttcatt aagaaatacg tactcattgc cctgctttaa ttaattttaa 2060161 gccctcgcac tatgcccccc cctgaattaa gtatttgatg taactttgaa attaagttta 2060221 tgaaaatctg tcacaaaccc ttatttcata acacatcatt tgtttcagct tccctcgcga 2060281 ataccggatt aatgctcggc tttaagatag tcaaccaatc tctccgcact gttcttaaca 2060341 tcttcttttg aaagatgaag tgtcccatat tgtgtaaacg caggaagaaa acgcattcct 2060401 atatagttag cagtgacttg aaacggtctg ataagctcgc tgatcgtgat attatattct 2060461 ccgcctgctt gataatcaga ttcctgtgcg cctaaggaga tagctaagag tagttctttt 2060521 ccatgcaatt tagttcctcc agttccataa gcccagccat gtgttaacac atcatcttcc 2060581 cattgtttga gtaacgcggg actgctgtac caatacattg ggaactgaaa aacgatacgc 2060641 tcatgatcta acaggagctg ctgctctttt tctacatcaa tgataaaatt agggtattca 2060701 ccgtacaggt catgaaccgt aatgtctttc tcttgcttta aacgattcat ccaggttttg 2060761 ttgacaacag acgtttccaa attaggatgt ataacgataa ctaatgtttt cattagactg 2060821 attatccttt ctttgccaat tagttattat tttttacgat aatgaattga ttctaatttt 2060881 aaaatagcaa ctttatttac acctatttta tcctttttca tgaattcagg gcaactaatt 2060941 gggcaccaaa atcaatgatg acttaagaca ttgttttgta gaaatccgat atacagaata 2061001 atccattatt tagaaaattt ctaccttttc cctcaatccg agctcgctct tcatgcggat 2061061 ggcctatttt aaaggaataa ctgactatgt tcatcagtta ttcctttaaa atacgaaagt 2061121 ctacgatatt tccatatcga tccgcttcaa tgtgacagca cccctcaagc agctgtttta 2061181 attttccacg tccgcgttgt acccttgatt ttgctccgga gtaagaaatg ccgagctttt 2061241 cactcaactc tttttgtgat aacccctgga aatcagttaa ctcgagcgcc tctcgatact 2061301 tttcaggcaa ccgtttgatg gtcgatcgaa tacacacagt tgcttccttg gtgaaatttt 2061361 cttcctctgc actgtcatta aaatgtagaa catcaggcaa tatttcgctt gttttttttg 2061421 tacggtaaaa atcaataatc gtatttctag tgatccgata aatccagctg tcgatctttt 2061481 gttcatcgat cagatttggg agatgcactt gtattttcat aaatacgatt tgcaagaggt 2061541 catcaacgat agattgatcg ttaaccctat gtgaaatata tgtttttaac ggctgatgaa 2061601 attgatccca tagatcctct atattcattt gaaaaaacct cctataattt tgcgtctgct 2061661 ttacatttgc ttcgtctttt taatcgtaac aaagagcaaa caattgttga atcaattgta 2061721 ttgcagctgt tgccaaaaat aatgataaag gagaggtttg ttgtggagta tacctattta 2061781 gggagaacag gattgcgggt gagccgttta tgtttaggca cgatgaattt tggagttgat 2061841 acagacgaaa agactgcgtt ccgtatcatg gatgaagcac ttgataacgg cattcaattt 2061901 tttgatactg ccaatattta cggctggggc aaaaacgcag gattgacaga gagcatcatt 2061961 ggaaaatggt ttgcacaagg aggacagcgc cgcgagaaag ttgttctggc gacaaaagta 2062021 tatgaaccga tttctgatcc gaatgacgga ccaaatgata tgaggggctt gtctctatac 2062081 aaaatcagac gtcatctgga aggatcactg aagcggcttc agacagatca tatcgaattg 2062141 taccaaatgc atcatatcga taggcggaca ccgtgggatg agatatggga agcttttgag 2062201 actcaggttc gctccggcaa agtagactat attggatcca gtaattttgc aggctggcat 2062261 ttagttaaag cgcaagctga agctgaaaaa cggcgattca tgggactcgt cactgaacag 2062321 cataagtata gtttattaga acgaacagct gaaatggaag tgctgccggc tgcacgggat 2062381 cttggtttag gagtagtggc gtggagtccc cttgcaggag ggcttcttgg cgggaaggca 2062441 ttgaaaagca atgccggaac tcgtacagca aaaagagcag atttaattga aaaacatcgt 2062501 ttgcaactcg agaaattttc agatttatgc aaagaactag gagaaaaaga agcaaatgtg 2062561 gctttggcat gggtgctggc aaatccagtt ttaactgcgc cgatcatcgg accacgaacg 2062621 gttgagcagc tgcgtgatac gataaaagcc gttgaaatca gtctggataa ggagattctc 2062681 cgcatgttaa atgatatctt tcccggacct ggaggagaga cacctgaggc atacgcctgg 2062741 tgatacattc attactcaat actgacattt ttcttaaata tttatactga actatcatat 2062801 taagaaagac aagagcatgt ttgtctcttg tcttttccac atcgtgctga aaatgctggc 2062861 taaacatcga caaaaatgct gccgcttaaa aaagaaccct aaacaataga gtaactggaa 2062921 agacaactgg cttgatcagc ttgggacccc tttcagctgt atttaaatca atcaaactaa 2062981 tgattcattg gcagtctaaa tattattatt gtttctttac aaaatagtaa tagcccctgt 2063041 aatgattgct aacaacgtaa taactaatga tgtaattaca gcccacttaa cggcaaacct 2063101 ttgaaatgac cccaagtcca ttttaagcat gcttactagc aatactgttg acgcaaccaa 2063161 tggactcatc agatgaaccg gctgccccat tatagaagcc cttgcaattt ctactggttc 2063221 tataccatat gctgaggcag cttctgcaaa gataggtacc ataccaaagt aatatgcatc 2063281 atttgataaa acaaaagtaa acggaatact agtgagtgct acaataacgg ggaaaaaccc 2063341 tcccattgat gaggggatga tggatattaa tgatcctgct atggcatcca ccatctttgt 2063401 cccggataat ataccagcaa atactcctgc tgaaaatacc aataatacca cggttatggc 2063461 attaccagaa tgctcggcga ttcgctcctt ctgcattttt acattcggat aatttatagt 2063521 aagggcaaga acaaaaccaa ttaaaaataa aactgacgga tgcttagttc caagcacaat 2063581 aaacaccatg atacttataa cgaggaataa attaagatat attaagcgtg gccttttcaa 2063641 ttgttcgctc tccaaagtag cagccatata agattgagag ctgtcctttg ttatatgtct 2063701 aggctctaat tgaacgatgc ctattcgatt cctctctttc cttcccatta gaaaagccag 2063761 aaatatcaca caagcaatac ctccaagcat ggtcggaagt aatggcacaa agaaatctga 2063821 aggatccaaa cccagcactg aaatcgctct tgtagctggt ccgccccatg gagtcattcc 2063881 gctaacgata ctcaacgaca gcattgctaa tgtcgccata accatgggat tcataccaat 2063941 tcttttatac aaaggtaaca ttgctgagac tgttatcata taggttgttg taccgtcccc 2064001 atctaaagcg ataagcattg ccaagacggc agaccctatc gctattttca cagggtctcc 2064061 ctttactata gataaaattt tttctattag cggatcaaat aaacctgcat caattaaaat 2064121 tccgaaaaaa agaatagcaa acaatagcaa tgccgctgaa cttgcaactg tttgaattcc 2064181 ttctaaaatc atgtcgccaa tacccttacc aaaacctcca ataagagcaa aaacaatggg 2064241 agtgatggtc aaggcaacaa taggcgagac tttctttgtc attattaata ttgtaaaaac 2064301 agttaccatc gaaaaaccta aaatagtaag catattacac ctccaagaat gcgctttcaa 2064361 atgacttttg attaacatat cttatacggt gtaataagtt aaataaatat ttttttactg 2064421 tgtttcaaaa aaaattctat cataacttta aatggttacc atttgttcac cctttaaaaa 2064481 atcaatgaat gctttaacga gtttgattcc taatgatttt tgatcgtaca ttagccaagt 2064541 atctctcatt agaggcttac ccttagcatt atacagttcc attgtgtaca aatgatcaga 2064601 ttcctgcagg caaatttctg gtgctatgga gtaaccaaga ccatgcttta ccatctcttt 2064661 gcaagtctct tgtcgatcca cttccattgc aataatgggg gcttgtttta gattcgtatg 2064721 catccaatct tctataatcg tttttaaaga agcatccgtt ttatatttga taaaaggtaa 2064781 aaaaggaagt tgctctatcg ttattggttt ttttgagatg atatgtaatt tttcccgtgt 2064841 cagccgttcc tccacccctt tccagcgatg gcttcctctc agtataccga cttgtacaat 2064901 accagcatct aataatttca tgacatctgt gctccagcct gtttgtacac tatattggac 2064961 attaggatac atagtggaaa attcccttaa taacttaggg agcttatatt gagcgaaatt 2065021 gcttgatacc cccagcctta gatgtccttg cacctctttg cttagattag agatatgatc 2065081 tttggtatct tgaagttcct gtagcattct tcttgcataa gcaaccaagt gttctccttc 2065141 cgcagtaaag gtaattcctt tatgcctttt ggtgaataat tcaattccga aaatctcctc 2065201 aatctttttc aaccgataag tgatggaagg ctgtgatgta aataatcgtt ctgctgtttt 2065261 tgttacactt tgttcttcgt gaagaatttt caataaaatc caatctttct catccatttt 2065321 catcttcctt tctagtcctt ctttcacaat tataaaagtt tttttatcga atattaagaa 2065381 aacttatatt ttatttttat ttttttacct tctacactaa aaaacataaa aaatactacc 2065441 tttaagatga ggatgatgac gatggtcaag acgaatgtaa caatcatgag aggcggaaca 2065501 agcaaaggcg tttttttcca cgaatcagcc atgcctaaca ataaaaacga atgggagccc 2065561 tttttgcttg atgtcatggg aagtcctgat aaaagacaaa tagatggttt gggtggcggt 2065621 aattccctta ctagtaaagt ggcaataata aagaaagcat atacttcgga tattgatgtt 2065681 cactatactt tcggtcaagt cagcatttcg gaagaaaagg tggactttaa ggggaactgc 2065741 ggaaatatct ccgctgctgt tggtccattt gctattgaag aaggacttgt aaaagcgaaa 2065801 gaaccaatga ctgcggtaag gatcctgaat accaatacga ataaaatgat cattgcggaa 2065861 gtagaagtgg aagacggtca ggtcaaatat gacggagatg ttacgatatc tggagtacct 2065921 ggatctggat ctccaatcta tttaaacttt catgatgccg ctggttcagt taccggtcat 2065981 ttattgccta ctggaaatag ttcggagttt ttagatacaa gtcaaggcca aatagaggtg 2066041 tctattatcg actatgcaaa tccattagtt tttgtggaag cgagcagtat cggcctggat 2066101 ggaacggaac ttgcagaaga atttactgat ctacagttgg ctcaatttga agaattaaga 2066161 tccattgcgg cagagaaatg cggctttgcc agtcgatttt cagctacaaa gttatcgccg 2066221 gctgtcccca aactggctat agtagcaaaa ccagagaaat ataaagatag tacaggtgct 2066281 tggcattcaa gcgttgagat ggacttacac atcaggatga tgtccatgca aaagccacat 2066341 caagcactgg ctgtcactgg agcgatatgt acaacaagag ccctttcagt ggaaggtgca 2066401 atccctgcaa gaatagcaaa aaaccactct acaaaggttc ggctagctca ttcttctggt 2066461 attattgaaa caatggtgga gcccactggt ataaagatcg tccgtaccgc acgacgtatt 2066521 atggacggaa cagtttatac gcatggagac tatcaaatga tgtagatgga ctgtgcaaaa 2066581 agcctccccc ctttccatcg ttaatagatg gattgaatgc gccttcttgc acagatccat 2066641 tgtaatcttg catggcttta aaaaagcctc tatattgttt tttatgaaat cgccaaggtc 2066701 ctttcatgta tctgcctcaa gcatgacata atcattatag agaaaattga atacttttta 2066761 ctgcaaataa aaagatacca acatcattgg tatcttttag attgagttca tctgcagcgg 2066821 tttcttttcc tcactgctta tttgattaca aaattaccgt actcgtttga acgaacatga 2066881 atcggtccgt ttagattata gttgttctcc ttggcgatag agcgaagcac gtccacacgg 2066941 gcaactgatt ctctccattc gtcacgggtg tcatgattgg ccggattcat cagatcgtca 2067001 tagcgtacgt ccaagaattt attcaaccac ttcttctcgt ctattccgtc tttaggtgat 2067061 ccgcccgctt ttttgttcgt acgtttaatc aaggcataaa aagagtcagg gtcatcacca 2067121 tcgccatgct gaataaccgt atcgtacatc acagctcttg ccaatgctgt ttttagtccg 2067181 gcattatccg atcgtttcat ggcaggctga taatacaaat ggtcatttac tttgtcttga 2067241 gcggcgcgaa attccttatc atttgcaagc gacttccagg cagaagcgaa tcccttgaga 2067301 ttgcttgtat catcgctttc ttccttggcc agacggcgca attcaggcag atactttttc 2067361 agtttgttat tcggaactgc ctttgtgtat acttccacta cttccaatgc atccccggta 2067421 gccgttgtaa agcctgcccg tccgcatgta tagcctcgcc cgtcatccaa tcgctctaca 2067481 tatccatatt ggatctccgt tgtgccgttt tcaaagatac ttgtcagctg ttccgcccgg 2067541 cgcttttgat ctttattcag tcccgccgca aaaaccgttt cgctcatcat cagggtaaaa 2067601 aacatggtga aaacaagtaa tgagatcgct gcttttttcc aaaaatctgc tttttgcata 2067661 ctgattttca tttcacttcc cctttctaaa tattgtaaat acagactcag tatacatgaa 2067721 gaaactgccc tattgttgaa aatacatcaa tttgtcaata ttttgaatct aaagtaatat 2067781 agcttgaatc ttactctatt cattgccaat cagccttagc ccctctcact gggaaggtcc 2067841 cttgattttc atactgcttc aactttcatt aacaagatgc cataaggctt tactctattt 2067901 tataatggaa gtgatcatcg aaaatcgtta gggaggtgat gtaatggcaa gcaagatgag 2067961 aatgccagat tccgcaacgt cccatgcaaa gcctactatt gggaaggcga tactttgcat 2068021 ggggtagact ttctaaaaga tcgcccaagt aagcttttct gatatagtgg ctttgcacct 2068081 tatttgacat aaaaaaataa ggagctggca gaaatggcat atgtaaaagc aaccgctatt 2068141 ttacctgaaa agctgatatc ggaaattcaa aagtatgttc aaggaaaaac aatatatatc 2068201 cctaaacctg aatcctctca tcaaaaatgg ggtgcgtgtt caggaacaag aaagctgatc 2068261 gatgacagaa acgcttctat taaaaaagca tttaaaaacg gcaaaaccat tcatcaatta 2068321 tctgatgaat atcacctctc tattgaaaca ataaaaaaaa ttgtctactc taaataaaca 2068381 aaacggaagc actgataaaa aataatcagt gctttttata tggcgagttt gtttcttagt 2068441 tatttcctgc atatgatacc attggccaat tgtgtaaagt taagggagat gagaagaaag 2068501 gaaggtccta caaatgacga taaacaatgg aacgttgcaa gtacccggcg cgaacatcca 2068561 ctatcaggtg cgtggctctg gtccaatcat tcttttggtc cacggaggag gcggtgatgc 2068621 cgacaagttc catcatgttg ccaatcatct ggctaactgg tacacggttg ttacttatga 2068681 tcgccgcggc cattcccgca gcaatctcgc caatcagatt gagggttacc gtgtggaaac 2068741 acacagtgac gatgctcacc gtcttctagc caaaatcacc aataagccgg cctatgtatt 2068801 tggaagcagc tccggggctg ttatcgggct tgatctgtgc atacgccatc ccgaacaagt 2068861 acatgtcatg atcccacacg aaccaatctt attgcagctt ctgcatggaa atgagctgaa 2068921 acaagccgag caattcatgg aagaccttaa gaaaaatcat cgaagtgaag tcattaaatt 2068981 aatgtcaaga ttagagacag acgaacaatc aaaggctgtc ctgacaaagc ggcttctcgg 2069041 caattcaacg tatttcactg agtatgaaat tcaaggaatt ctcagctata cattagattt 2069101 cgaagcatta aaaactgtgt ttacatcttc accgatgaag atactcccag ctggcggaag 2069161 tgcttctcgg gagctttttc cttatcgttg cgcgaacgcc ctagcggaac aattggaaac 2069221 agaatgggtt gaattccccg gaaatcatac ggggtacaca atgtaccata aagaattttc 2069281 tgagaggtta cacgacatgt tagaaaaaga aaagaaacat acgtgttaag gattgattaa 2069341 aattttcaaa ataggacagg tgaaactaac tatggaattg gagaagattt cacgaagcgt 2069401 aaaaagaact tttcactaac gagaacgcaa tgtgagatgt ttaaccaaag tgatattagg 2069461 gatttcatcg aaaaataggt ttgtacatta cgttctccta ttgattattt cctatcttaa 2069521 ttccgtattt tataccatta gatacaactc taaagcggct cgttattttg tcctcaacaa 2069581 caaccagtgt ctaacatcat gaatctcttt tgaaaatcac cacaaatgca ggtatggaag 2069641 acttcatcgc agcaaaaacc ataccaacta ttgttgttgg tatggttcgt cctagatagg 2069701 cccttaagaa gagattctat tgtacggagt atttagctaa ttgcatttgt aaccgacagg 2069761 gccgtctgaa cctgtgtaca catatgtgtc agacacatat ccaatattca cgacaccccg 2069821 ggaatctttc cactggattt ggtcccagat attactcgtt ccatacttcc ctgtaacagt 2069881 cgttccataa gcgtaacaat aataaggaac acgggagcca ctcggaatgg aaagcataat 2069941 aggataattt gtaccaggac cgctgcgcat attgacaggc gcaccgctgc ttgttgagac 2070001 agtaaagtac tgaacggcaa gtgcctgact ggaaaaaatg aataaagatg caatcatcac 2070061 ggttaacata ctcagcattt tcagtttagt caatgtcatc cctctttctt caattccttc 2070121 attttaagaa acgatagaac ataggctacc agctgcattt aggaacaacc ggaccgtctg 2070181 agcctgtata catatatgta tcagagacaa atccaggaac gatctccccg ctggcaagcg 2070241 tccgctctgt gtaattccaa atattgctcg ttccatactt tccagttaca gttgtaccgg 2070301 ttttgtagca atagatcggg atgcgggttc cgctcggaat ggtcgttaca attccccaac 2070361 ttgtacctgg gccgctgcgc atgttgacag gagcaccgct gcttgttgaa accgtataat 2070421 actgagccgc aagtgcatgg ctagaaaaaa tgaacacaga tgcaatcatc accgttagca 2070481 tacttagcct ctttaactta ttcaccttat accctcccct tataaatgcc gtacgtttga 2070541 ctttcttaca tccagttaag gatttacttt cagataccat gccccctccc ctcccatata 2070601 tttatcaatg taccataaac tagatctttc aaaagtggaa ttattcctat gttttcgaca 2070661 attaaggata caaaataaat ggtagtcagg cttgatattg atggtgtgtt acatttggct 2070721 cttaatcatt tgtccagtcg gtaatcacga ttgacaatca ggaaaaagga catggatcaa 2070781 gcggcttcgt ttccaccaat taactcaatc agtgtactgc ttccttgtat ccacgcttct 2070841 tctcgattca tagatactcc acctttttca ccaatcaaaa acggacacca tacaaatcag 2070901 cgtaaatgct gcaagttcag tgtccgcaac ctattatgac tttgctttct tttaccaggg 2070961 cgtgtaaaaa tgattaggta cgttatcaaa cgttattcta tgattttgcg agtcaaaaaa 2071021 tcataacatt ttatatattt caatcagatt atgatctgga tctctgaagt gagcaactcg 2071081 ggcactccat tccttgcgat catgcggttt attctcacat ttaactcctt tttcgtgtaa 2071141 atcgtcatac gttttatcaa catcttctac cttaaactga agcaaaaatt ttgattgagc 2071201 ttctccttcc aaggactttt tttcctctcc aacgatttca gccatcgttt ctcgagataa 2071261 aagctctatt ttcgtttccc cattatcaaa gagtgcatat tccatttcat tctctaacca 2071321 acttattgga agtcctaatg aatctttata aaactcgacg cttttcttaa aatcattcac 2071381 caacagtcta atttgtaaca gcttcatatc gagtgcctcc tataaaacca tacttttact 2071441 ggtcatccaa tttaatgata ccaaagaaac ctgacagcac tatgtcaagt ttccatactt 2071501 cacccttatt tcagatttaa gtgcagttta gtccatgtca taagaacgag caaaaacagc 2071561 gattcttaaa acaaaaaatg ataccgagtg tattttctgt atgcttcaac ttcatttcgg 2071621 gaaatgtaac gttgataaaa ggaggttaca tcaatatgga tcatcaaaca ttggcagctc 2071681 atgaggctgt tgacttacat gaaatcgtga actttaaaac actttgtata gcgaaatcaa 2071741 agttaatgca agggcttgtg tttgaccaag aactgaagga cttgatggaa aaagatgtac 2071801 agcaatccat tcaagacctt actgaattac aagcggttta tgagcgtgcc tcatttcagg 2071861 cccctgtccc tcaaagccgc ccaacgccaa tcatcaattg aaagggaggt aagcctcttt 2071921 gaataatgat catttagacc ccattaattc gctgaatgtg cctgaactag cagacactac 2071981 attcgcgatg gattttctta tacgagctaa ggaaggcgta aggaatactg ctgtagcttt 2072041 gacagaaacc gcttcaccag atgtaagagc actgcttcgg aaacagctga tgcaaggaat 2072101 tgcgatgcac caagagatta cggaactgat gatcagcaaa aagtggttcc atccatatga 2072161 gctgagcgaa cagtataagc tggatcagct ctctgcaaaa aacacgatca tggtcggcaa 2072221 tatgaacctc tttcctgatg aaacaaatcg caaagggatg tttgaccgga cacctgatga 2072281 acactaacac tggaggtttt acagcatgaa ggcagtaacg tatcaaggca ttaaaaatgt 2072341 tgttgtcaaa gatgtccccg atccaaagat tgaaaaatcc gatgacatga ttatcaaagt 2072401 caccagtaca gccatttgcg gatcagattt acatttaatc catggattca ttccgaatat 2072461 gcaagaagac tatgtcatcg gccatgaacc gatgggaatc gtcgaagaag ttggttctgg 2072521 ggtgactaaa ctaaaaaagg gagatcgggt aattattccc tttaatatag catgcgggga 2072581 atgctttttt tgtaaaaacc agctggaaag ccaatgtgat cagtctaatg acaatgggga 2072641 aatgggtgct tatttcggct attcagggca aactggcggt tatccaggcg ggcaagctga 2072701 atatttaaga gtgccgtttg cgaattttac ccattttaaa atccctgaat cttgtgagga 2072761 acccgatgag aaattaagcg tgattgccga tgccatgacc accggctttt ggagtgtgga 2072821 taatgccggc gtaaaaaaag gcgatacagt tatcgttctc ggctgcggac cagtcggcct 2072881 gtttgctcaa aagttttgtt ggctaaaagg cgcaaaacgc gtcatagcag ttgactatgt 2072941 aaactatcgc ttacagcatg cgaaacgtac aaacaaagta gaaatcgtta attttgaaga 2073001 ccatgagaat acagggaatt atttaaagga aatcacgaaa ggcggagcgg atgtagtcat 2073061 tgacgctgtt gggatggatg gtaaaatgag cgatctcgag ttccttgcca gcggcttaaa 2073121 gcttcatggc ggaacgatga gtgcattggt cattgcttcc caagctgttc gcaaaggagg 2073181 aaccatacaa attacaggtg tgtatggagg cagatataac ggttttccgt taggagatat 2073241 tatgcagcga aacgtcaata tacgctctgg acaggctcca gtgatccact atatgccgta 2073301 catgtttgaa ctagtatcga caggcaaaat tgatccggga gatgttgtca gccatgtcct 2073361 gccgcttagt gaagccaagc atggctatga catttttgat tcaaaaatgg atgattgtat 2073421 caaagttgtg ttaaagcctt aaaaaacgga ggttacagaa atggaatacg ccttacacga 2073481 agtgcttgag gttcaggaaa tgactgcatt taagacactt tgtttgacga aatctaaaac 2073541 aatgaaagca ctggtatctg atccgaagct gaaagaaatc atgcagcaag atgttgatat 2073601 caccacacgc cagttgcagg aatttgcctc tattttatct aatgcaaagc aagaatgagg 2073661 agatgaataa atcatgaatc ctatcataga atatctgact ggcatgaatg ttctaacaga 2073721 ccaaatcatt gctatggact tattaatttc agcaaagaac ggagtcagaa attatgcgat 2073781 ggcagccact gaagccggaa cgcctgaagt aaaagaggtc cttatccgcc atttggaaga 2073841 agcactcgat atgcacgaac aactctcaag ctatatgatg gaaaaaggct ggtaccatcc 2073901 ttggaaccct gacgaacaag tcaagctgaa tttaaaaaat attgatacag ccattcaatt 2073961 gccaaccctt taacatacaa tgactgattt gctgaggaac agtattgatt ggccacaact 2074021 gttcctcagc ttcaaaatga gcactgtttg ttcgggtcct atgaccgtaa atagattaac 2074081 cgcttttctc catctgatct ccgataatgt ttgcaaattc tccaatccaa ataaggaatc 2074141 gtaaccacct ctttttatgc gatctcttga tggagaaaac aggccagaaa caaaatcctt 2074201 cgtttttgac ctgccctctt cacacgcaaa gaatgctacc ttctttgctc cactgatccg 2074261 tgaagacttt ccgttttagg cctgcttttg agctttgcct cattttcacg caatttccca 2074321 tcataatctt taatttttgt gtctaatctc ttaattgttt catcaatttc tttccgcttc 2074381 tctatcagcc gctgtcgttc gtcagccagg atattttttc gagcttctac cgtacggtca 2074441 ccttcggtaa ataatgttgt atattcaatt agcgcttcta tcgatagtcc cgcatttcgc 2074501 atgcatttaa tgaattcaat ccatttgata tcttcttcat catagtcgcg aatgccgctg 2074561 tcttttcgtt ttacaggcgg gattaatcct acacgttcgt aatatcggag tgttgcggct 2074621 gtcaggccaa actgctttgc cacctgagca atattcatga tcttcacctc tctatcctgt 2074681 atgttgtgaa ggtaacactt aaagttaact ttaagtcaag ctcaaaacaa gtggttagct 2074741 gctgaatctg ggtttatata ttcgggactt gccttaaagc acactttaaa ctctatactt 2074801 ctccatgcac taaaaacagt gtagttggag ggattgctga atggcaaata aacacactgc 2074861 cggaagagaa caattaggag aatttgcgcc aaagtttgct gaacttcatg atgatgttct 2074921 attcggtgac atttgggcaa gagaagaaga actttcatcc cgggatcgca gcatgattac 2074981 agtttctgca ttaattactg actgtttctc agcttataaa tcaggttcat tttaaatggt 2075041 ttttttaaaa aacccttgcc ttaaagcaga ctttaaggtt tatcgttatg ttgaagacac 2075101 cataaaacat aaataagtgc atgtttttat ttacaacact tatgatgaag aaaggatagg 2075161 ttcgtatgtg taatcaacat caaacccgtg tattaagcgt gtcacatgca aaagccaaat 2075221 ttgaacaaac gacgattgag cgaagaggat tacggccgca cgatgtctta atcgatatta 2075281 aattcagcgg catttgccat tcagacattc atagcgcttt tgatgaatgg ggcggtggca 2075341 tcttcccaat ggtgcctgga catgaaatag ccggtgttgt aacagccgtt ggaacaaaag 2075401 tcaccaagtt ggctgtcggg gaccgcgttg gtgtcggctg ttttgttgac tcttgcggag 2075461 aatgcgaata ctgtctcaac gcagaggaac aattctgcac gaagggtgtt gttcaaacgt 2075521 ataactcagt agactacgac ggaaacccca cttatggcgg gtacagccaa aaaatcgttg 2075581 tcactgacag atttgttgtt cgcataccag atcgtttgga aatggatgtt gccagtccgc 2075641 tgttgtgtgc aggtatcaca acgtattccc cgctgaaaca ctggaatgtt ggccctggta 2075701 aaaaggttgc gattgtaggc gtaggtggcc ttggacattt ggcaattcaa tttgcacatg 2075761 cgatgggtgc agaagtaacc gtcctgagcc gttccatgaa taagaaagag gaagctctgg 2075821 aactcggtgc aaatcattac tttgcaacaa gtgacccagc cacattcact gcattggccg 2075881 ggcgttttga cgtgatctta aatacggtat cggcaaatct cgatgtagat gcctatttat 2075941 caatgcttcg tatagacggg acacttgtaa gcgttggagc tcctgccaag ccggacacat 2076001 acagtgtgtt ttccctaatc atggggcgcc gcagcattgc aggttctcta gtcggcggaa 2076061 ttcaagaaac tcaagagatg ctggatttcg cagctgagca tggcatcgaa cctaaaatcg 2076121 aagtcatcgg agctgaccaa gtggacgagg catacgaacg tatcctccga agcgatgtcc 2076181 gttatcgatt tgtgattgat atttccacat tgtaataggt tagtccttat atgggctgcc 2076241 gcttttattg aaactcacga aaaatgatct ctttaagcaa atattttgaa ggccggtcaa 2076301 tcttcctgtt attctatgaa tagagagtta ttaggagggt tttttatgag caaaaaaatt 2076361 gcagttcttg ttacagacca attcgaagac atcgaatata caagtccggt aaaagcatac 2076421 gaagaagctg gctacagtgt tgtggctatc gatttggaag ccggcaaaga agttaccggt 2076481 aagcatggcg agaaagtaaa gattgacaaa gccatctctg atgtggatgc aagtgacttt 2076541 gatgcacttt taattcctgg gggattctct ccggatttgc ttcgtgcaga tgaccgtccg 2076601 ggtgaattcg caaaagcatt tgtcgaaaac aaaaaacctg ttttcgcaat ttgccacggc 2076661 ccgcaagtac tgattgatac ggatcttcta aaaggcaaag atatcacagg ctaccgcagc 2076721 atccgcaaag atttaatcaa tgccggtgca aactacaaag atgcagaagt agtcgtcagc 2076781 cacaacattg tcacaagcag aacacctgat gatttggaag catttaaccg cgaatcttta 2076841 aacttgttaa aataacaaga aggcacagac tgttcgggtc tgtgcctttt ttaaaattaa 2076901 gactccttcg ttacattctg aaagacagca gtcgcgtccc acacattcaa gccaaattgg 2076961 ccttctgaaa atacggaatc atgtgcatca atcacaagac gatcatctaa atagatttta 2077021 aagcgatcgc cctcggcctc tgttttcaga tgatactttt tattaacgtc tatcggtgtt 2077081 ttgtattcag caatgacaga agcagcaccg ttctcaaatt taaagaattt cactaggtca 2077141 tgcttcgcat ccacattggc aaggtaaccg tttttggcat ctttgtcaga gcgaaacatt 2077201 agtgctcctg cccctcttcc gtttccatcc ttaatggtga tatcagattc ataagtgaag 2077261 tctgacccgg atgctgaaga caagataaag gaatcgccgt ccgacctccc ttgtttcccc 2077321 tcaattgtgt ctgcccacgt gccatttaca gtcgtccagc cagtcatatt ggacataaaa 2077381 ggtgtcgttc cccatacctt ttttaaaggg tgtatcgtta aagattttac ctttacaccg 2077441 ccatttgcag catataattc aagccctttg cttgatcggt ctgggagaat aatatccgtt 2077501 atgacctgct ttccgtcatt cccaaatact tcaaccgagg agcggtcaac aaaaatgcgc 2077561 aacttaacct tcccatttac cggcttcaac ggggctgttt cttttccggt gttaaaggcc 2077621 ggattaaagg tgtcgttgcc tgactcgctc cggtcaacga acaatttggc gttccttcgg 2077681 tcatagccga ccttcgtaaa ttgattttca cctgttcgga ccttaaaacc aaattcagca 2077741 gctgaaccag ggcttacttt aaattctgca tttatttcat aggcatctcc agattgcccc 2077801 gctaacacat tatgacttgc aggcgatatg gtcagattct tccacttctt agaggttccg 2077861 cgaatggttt ccagctcttt caccggtgtt tggaccactc taaccccttc ggtaaacgct 2077921 ttcaatttta actctcttgg aatggacgtt gcacttctcc atggggatgt cggaacatca 2077981 ttcgcatatt gccaattgct catccaccct aaccatagcc ggcggctgtc tgtggatgga 2078041 atatcagacc aggatacagc cgcataaaag tctctgccgt aatccgtcca gagaactttg 2078101 tttggcgggt tttcattttt aaaatgagtt ccatcaaagt cccctacaaa atattgcatg 2078161 cctgatcctc ccgagaccgc tccgtttccg acactgacct gcatgaccca tttcttttga 2078221 ttcggattgc cgtctaccgg aagctcaaat aaatccgggc attcccatac tcccccgtgg 2078281 cttccttgat cctgtccaaa ttcacttgca tacgtccact gcttcagatt ttttgatgta 2078341 taaatgagga ttcggtcacc ggccgcaagc accatcaccc actttttttc tttctcatac 2078401 caaaagactt ttggatcgcg aaaatctttt ttacccgggt ttggaatgac agggttgcca 2078461 gcgtacttcg tccatgttct tcctttgtcg ttgctatagg caatactttg cacttgatgg 2078521 ccttcccgat cctgtgtata aatggccaca agcggcttct ctttgcctgt ttgaaaaccg 2078581 cttgtgttat ttttatctac aactgcgctt ccagaaaaga tcgtgccttt ttcatccgga 2078641 tacagcgcaa caggaaggtg ttcccatgta accaaatctt tgctgacggc atgcccccaa 2078701 tgcatgggcc cccactgaag cccgtatgga tggtattgat agaacaagtg atattcccca 2078761 gcataatata ccattccgtt tgggtcattc atccagtttg cctccggtgt gaagtgatat 2078821 tgaggacggt aatcctcatc atagtagctt gaatcggctg catctgccga aaatgccata 2078881 gtcaacagca gggtgaacat gatcatgact tgaatcagtc tctttttcat ttgttccttc 2078941 gctcctctct tcatgtttga acactttcaa aagagactgc tgcgcaagct ggtccgtttc 2079001 tggcaattct cctctgtttc actgttatcc gaatgattta tatatgaaaa gactgctgca 2079061 gtttctctct ctttccttca cacaccttat gctaagaatc cagcccaata cccgagaatc 2079121 ccgatgacaa agatgccgca aataatgaga agtggattca cccctttgcg aagcatccat 2079181 gccaccaata acgttaatcc gagaggcagc gcccccggca taatgctatc tagcacgttt 2079241 tgtaccgttt gaacatctac ttttccgctt tcatccttaa tcctggatac aacgattgga 2079301 atgttgatgg tggtccattt ggacacgaga gcccccataa caaataaccc gagaatcgaa 2079361 gcgccctctg taagcttttg aatgcgattc cccgctaaat cctgaagaat ctccattcct 2079421 ttcacatagc catactttaa tccgtaatat tttgtgctta atcttatggc attcagcaag 2079481 aaaaagaata gcaaaggacc ggcaatgttt cctcctaaag caagggaggc tcctagcgca 2079541 gctaagacag gacgaatcgt tccccaaaaa attggatcgc ctacgcccgc tattggtccc 2079601 atcaaaccga ttttcattcc gcttatcgct tttccgtcaa ttcctttatt gttcgccatt 2079661 tcttcttcca tggctgccgt cacgccaaat ataggcgctg tcagccacgg atgtgtatta 2079721 aaccattcca aatgccgctg taaggcttcg tttcttttcg ctccgggacc gtacaatttt 2079781 ttgatcgccg gtatcatgac ataacaatat cccattgcct gcacacgttc gaagttaaag 2079841 gaaccgagta aaaaatttga acgaataaac atgctgaaaa tttctttctt cgttaatcgt 2079901 ttttctttct ccattttttc ttccccctca tcgtttaggc atcaagatca tcatcatcgt 2079961 catcataaac agcaacactg ccactgtctg atgcggccgc gactgctccg tgagcgcttt 2080021 gtttttgcat cacctgctgg tataaaagcg ccagacagag accaagggct ccaaatccca 2080081 ctaagttaaa atcggtaaac gccgctaata agaaaccaat atagaaaaat ggctttaaat 2080141 aaggaatatt catcatattg atcaccatgg catacccgac aaccacaata atgcctccgc 2080201 ctatttgcag tccttttgta atgacatcag gaatatttcc caggaacgcc tgaacagcgc 2080261 tgacactaat taaagcaaca atcaatgtag gaatcatgac gcgcaaagct tgaaacacca 2080321 tcgcggtaat atgcataatt tcaattcctt ttatatttcc cgcttttgca tattgatcag 2080381 cgcggtggat gaaaaagaca gtgatcgtcc gaacaaaaat cgtcagcgcc tgacccgcag 2080441 ctgctaaagc aacagcgaca gcaatccctt cgccaattcc ttgatcagcg gtaataacta 2080501 aaatggttga gatgacagag gcgatcgctg tatcaggtgc catggcaagc ccgacgttca 2080561 tccagccgag cgccatcagc tccagtgtgc ctccaagaat aattcccgtt tttaagtccc 2080621 cgagcaccaa gccaaccaac gtacaggcca ctagcggccg gtgtgtctgc ccttcatcca 2080681 atacacttgc gattccggtg attgctgcaa tgattaacaa caaaataatt tgtaatgaag 2080741 acatattctc atccccttga ttattttgtt acgttccgta aaatctgtac aaaatcctca 2080801 ctggcatctg aaggcagctg cctcaattcc agtttcacgc ccttgtcact taatgtttca 2080861 aatgccttta tatcttgttc tgtgacactg actgattttg tgatttgcct gcgatgattt 2080921 tcaaaacgca ttcccccgac gtttacggtt ttgatcggta cacctgcttc tataagagat 2080981 acaatatcgg acggattttc aaacaagagc attgccgtta ccccttcgta gcgcggacta 2081041 tgaaatgctt ttgccatttt agaaaccgag acggcactcg cctttacatt tgaaggcgca 2081101 acagaaagga tcagcgtttt tctcatttcg tcctgagcaa tatcgtcgga gacaacgatg 2081161 attcggtcgg ctgcatggac ttttatccac cttgtcagga tttggccgtg aataaagcgg 2081221 tcatcaattc ttgctaacac aatgttcatc ataattcatc ctctcttgta tcttgattgg 2081281 ctgtttttac tttttctaaa tgttcactgc acacttgaaa gctttgctga ctcattgctt 2081341 ttaagttgtt cagcaaatct ttgagagcca gatgttctct caggcttaat acctccagca 2081401 gaatcggcag gtttacgccg gcagccatat ccattctttg atcctcagca ataaaggaag 2081461 ctgccgcgtt atatggcgtc cctccaaaaa tatcgactaa aaaaagcact tcatgttctt 2081521 ccgggatatc cttgagcgcc tgatgatatt tttcttgcag cgtttgtatt ccttcccctt 2081581 tgaaaaacgg cactgcaatc aggttatttt cttcaccgaa tatcatccct gaagactctt 2081641 ttaatgctat gggaaaatct ccatgaccgc tgataataac tgaaatcata tctattgctc 2081701 ctttcctgtt ttgtacatcc atatataatg caaggatcgt gccaacacag ttgtgttaag 2081761 cgttttcatt gttatttcag ccaatagcaa tttgttgttg aaacacttaa aacgaaaaaa 2081821 ataaacctgt attaaaatgg tgttccattt aatacaggtt catatgaaaa aactgttttt 2081881 aaaacagctg gccatgcact tcttcagcaa atatggcggc tataaataat ttttcatcat 2081941 cacttatgcg aagtccgagc ttttcttcat aaggggctaa tgttcgctct gtcacgtaca 2082001 ccatttcctt cagctgatca ttgatctctt cttcctctga gaaagcgatc ggattctgct 2082061 taattaccct ttcaaaggcg aaagccgtgt gcataatgac tttgatcaaa accgcattat 2082121 tgaaaatgac ccccagctca tcctgaacgg tttgcagcca ctccaataac atgtcgatca 2082181 catggtgggg attcaagaag acaaggtatt ttttcaggct atcctcgcaa agctccctga 2082241 caataatatt tgcttcgttc aatccattgc tcaaggagat gcttcctttt gtaatcgcct 2082301 gttgaatcag cttctctccc tccccttcaa ttaacacttc taaagataca tgcggagcat 2082361 tgattttagg gtctttcgtt ccgactgtcg caaggatttc atactctttt tcgatttctt 2082421 ttatgctgtt ggccagctta atcgatgata cggtcaatat gtgaatgggg gtatcggagg 2082481 ccttgtttac gatcgtggtt agaatgtctt ccagcttttt ggccgttccg ctacccgtcg 2082541 tgcagatgga taccaatgcc ttctttttgc cggatgccgc tggctgacgc tcccacaact 2082601 cgataaaatc cttcgtgacc gattgataga tcgcatgcaa atttaaattc aaatagttga 2082661 cctttctgac agcatccagc accattgaag tcgtaacatt gctgatcgtt ttaatagaaa 2082721 tgcctgtctt ttcctccagc ctgctttcca gcattgcaag cgaccccata tctaccagca 2082781 ttaaaacacc ttcaccttca tcaacctgtt tcattttttc tgctacgcat tcaagaatgt 2082841 ccgaaggtga aacagtaagc ggcatgtcaa ctgctgcaat cggcgtactc cctagcagtt 2082901 ctgtcgcgac ttcaaccatt gaactcgccg tgctgtttcc atgagctgcc acgataatac 2082961 cgactctttt gttctccttt aacgatttga tggaatgaat taacatcgtt aagtagatga 2083021 cttctatttc aggaatagcc actttaaaat attcctgaat tttatcttta aaaatcatcg 2083081 ccacccgata ttctttcaca tgggtatcac gaatttcatc tgtctcctgt gtattcaaaa 2083141 catcaatttg ctttcctcgc tttaaaaatg cgtcaatatg catactcaag aaataaataa 2083201 acttacggtc aaatgtgcaa tccagctcat gttcagctat ttcttttaac tgttttgtca 2083261 tttgaatcac atcgtcttca acgaatgtca gcaggttgtc tttttgaaaa gcttgatgat 2083321 gaaaaaaact tctgacatgc aaatggacat cagtcaagat gtactggtta atatcctttt 2083381 tggataaacc ttctttcata agcgttttca ctttttcctc aatcaaatga tataagttaa 2083441 atgagaggtc ttcgtcaatt tttgttgttt catcttctac aatcggagag ataatcgttg 2083501 taatattgac atattcagaa atggctttgc ttctttgcat gtttttgctg ctggacatcc 2083561 attcttgctt gatttcatca ggcagatcgc gaacagtcag ttcaataact tcatttctgt 2083621 caaggttatg caaaaatccg tgtgcgcaaa ctaactgaac atttgatttc agctgtccga 2083681 cattcccaaa tttcgcagag tgaataagcg cattatagac atcgatatgc acactcagat 2083741 tcttcttaat tcgctctgct tctttcccta ataaaaacgt cgtcagatcc actctttcat 2083801 taagcgatcg ttcttcaagc gaaggaatat gaatggtcat tgggattctt cgcaaaaacg 2083861 ttttcaatag tgcagaactc ggattttctg tagtcgcaca aataaacaat acgttcgatg 2083921 ttcgtttatg ttcagattct ccaagcctgt tataagaacc gctgtcaata aaataaaaca 2083981 gcatttcttg tccctcggga gggagacggt ggatttcatc cataaaaaga atgcccccat 2084041 tggcctgttc gactaaaccc gccttatcct cggcagcacc tgtaaatgaa ccttttttgt 2084101 gtccgaataa ttgagaaagc aataattgag ggttgttgta gtagtctgca cagttaaatg 2084161 taataaatgg tgcgccggcc ttcaatatgt cagagtaaat ggcaaactgg taaattcggt 2084221 tcgcaaaaag ggatttaccg gaaccagtcg gccctaggag gagcatatgc agaccgttcg 2084281 gcggataaaa gacagctgct tttgcctggg agatcgcttt cttcaaactc ccttttgccc 2084341 ctatcataag ctctagggga ttcgtggaaa tgtgttgatg attttgcttt gaatttccgg 2084401 aaaacgcctg aaggtctttc acttccatca tctctgtatc ccatttcttg ttgaataatt 2084461 tttctgctat ctcgactggg atgtatctta caggaaatgt tttaattttg atgacctttt 2084521 tggaccggac gagattgttc aattcaaagc tgacattgga ccgctccatt ttcagctgct 2084581 cggcaatctc ctttgctgaa ttcccttgta tttttaaaag atgatctaag gttgaatcat 2084641 gaaaattatg cttgagctga tggtatattt tatctattct tctcacgtct atcatccttt 2084701 gtccttatta gataagccat taacaagaat atttcgaaac tttatagtcc gcgttgagat 2084761 ttacacgttt aaaaaggtct ctatagcaga ttgacaaagc tggcttttat gcgtatatgt 2084821 ttacatgttg aatcatttgc acctcatatt agtatgatag atgctcagtt ctggagggcc 2084881 agtccccttc aaaagtaata atcagtaaac agtttatcat tctcggggaa tgtaatgatg 2084941 tcaaaataat caatgacaaa aaatgaatct tatagatcat gacaaattac ccaaatataa 2085001 ccccttaagt tcgttcacaa ctaaaaagac ggacactcta tgtgaccgcc acagtattac 2085061 aatttgcaaa acttcgtcat ttttgcaatc cacattggag gttaaggaat ctgtaagctt 2085121 aaaaacttta tctccgatcc tatcgatttg atccccctgc cggcctcaat catagtgggt 2085181 atgcaattat acaaatcgtt accgattaaa actagcctgt cagattgtcc aaatgacttt 2085241 cctgttttac tctgctattc aggtagaatc acgagtgaaa aatagagcca caagacatgt 2085301 aacagcactt aaaatagttt taaaatttaa aaataaaagt atctattctt ttaaatgtta 2085361 taatatccga taaaacttta ctcatctttt tattactgga ggaaaataaa attgataggc 2085421 aattctagca aagacaattt tggccagcaa cagaaattgt ctagaggcct taaaaacagg 2085481 catatacaat taatggcgat tggaggtgca atcggtacag gtttattttt aggttcaggt 2085541 aaatccatcc attttgcagg accatccatt ttatttgctt acttgatcac cggcgtattt 2085601 tgctttttca ttatgcgttc gctcggagaa ctgctcttat caaatgcggg ataccactct 2085661 tttgttgatt ttgtaaggga ctatttagga aacatggcag catttatcac tgggtggacc 2085721 tactggttct gttggatttc cctcgcgatg gctgatttaa cggcggtcgg catttatacg 2085781 caatattggc ttcccgatgt gcctcaatgg ctgccgggtc ttcttgcgct tattatcctg 2085841 ctgatcatga accttgccac cgttaaactt ttcggagaat tagaattttg gtttgcattg 2085901 atcaaagtca ttgccatact ggctctgatc gtaactggta ttctcctgat tgcgaaaggt 2085961 ttttccgcag cttccggccc tgccagcctc aacaaccttt ggagccacgg cggcatgttc 2086021 ccaaatggat ggcatgggtt tatcctatct ttccaaatgg tcgtcttcgc tttcgtgggt 2086081 attgaacttg ttggactgac agcaggtgaa acagaaaatc cccaaaaagt gatccctaaa 2086141 gccatcaatc aaattcctgt ccggatttta cttttttatg ttggcgcact tttcgtgatt 2086201 atgtgtatct atccttggaa tgtgttgaat ccaaacgaaa gcccatttgt tcaggtcttc 2086261 tctgcagtag gcatcgttgt ggctgccagt ttgatcaatt ttgttgtatt aacatcagcc 2086321 gcatcagctg caaatagcgc tttattcagc acaagccgaa tggtctattc acttgcaaag 2086381 gatcatcacg cacctggact attaaagaaa ttaacttctt ctaacgtgcc aagcaatgcg 2086441 ctgttctttt catccatcgc cattctgatt ggcgttagtc tgaattattt aatgcccgag 2086501 caagtcttca cgctgattac aagtgtttca acaatatgct tcatttttat ttggggcatc 2086561 acggtgattt gccatttgaa atatcgaaaa acaaggcagc atgaagcgaa agcaaacaaa 2086621 tttaaaatgc ctttttaccc attatccaac tatttaacac ttgcatttct cgcgttcatt 2086681 cttgtcatat tggcactggc gaatgataca cgtattgctt tgtttgtcac cccggtctgg 2086741 tttgttttat tgattatttt gtataaggtg caaacccgca gaggacataa ggtgaaataa 2086801 aaaaaagaca agggatactc actcccttgt ctttttatat gtgtcaaaca ctaaattaaa 2086861 ctttggtttc aaatttcatt cacttcattt aagtgttaac tcaaaccagt tttgatgccg 2086921 aaacctacta atattattcc ggtaattttt tgaaacactt tctggaactt cgagtttttc 2086981 atccattttt ttgcgtaatc aataatataa acaagaaaca ggaaccacaa caccgctaat 2087041 aaggttagga ttgaagctaa aatgatgagc tgctggttta tatttccgtt caaattgata 2087101 aattggggca tgattgtaac atacaccaaa acagttttag gattgagaat gttactgagt 2087161 gatccctgca taaaggaagt tttataataa cgtttcggag aacttgccat attttttgct 2087221 tgggattgca tgtcatctaa cgaaaacata cttttagcaa aaaaactttt tacacctaaa 2087281 taaattaagt atgccgctcc caaatatttg atcgttgtga aaagaatcac tgactttgcg 2087341 attaccactg ataatcctaa aatggcaatc accgtccaaa aggaaagtcc tgtcgccaat 2087401 ccgagaatgt tataacggcc ggctttcgga ccatacctaa gcgtattttt catcacaagc 2087461 atcgtatctg cccccggtat gataaccatc atggcagcga tcggtatgta tgcgagtaag 2087521 ctgtgcattg ttctctcccc ctttaaaaat cccctcaatc atatagtgac tacaaaagta 2087581 actacttata aaagtgtatc aatgcgtttg gaataaatca atatgatttg ttaaaatagc 2087641 gattactaag gcagcgattg ctctttatat tggaggatat atgaaagaaa atatgttaga 2087701 cattttaaaa aacctcaatt ttacagaata tgaatcgaaa gcgtatttag cattattgca 2087761 agaatcacct ttaacaggct atgccgttgc caaaaaatcc ggagtgcccc gttctaaaat 2087821 ttatgaagta ttggaaagtc ttgtcataag gggagatgtt tttgtcagtc atggaaatac 2087881 gcctcagtat gttccagtcc ccgcaaaaga actgattaaa aaccgccggc tcaaagcgga 2087941 agagcatttt gatcaggctg agaaatattt tgaaaagttc gagcagaccg caaatgaccg 2088001 ggaaaacatc tggaatatca ccggccgcag tgaaattctt gaaaaggtga aggcttgtat 2088061 cttatctgcc aaaaaaagaa tcctcttaga aatatggaaa gaggatttta aggagataga 2088121 agcagagctc aaacaggcgg cagaacaagg cgttattgtc accattattg cgtacggaga 2088181 catcgtatct gattttgcca atgtttacct tcatgatatg agcagtgaaa ttacagaaga 2088241 gtatgacgga cggtggcttg tctatagcgg agatgattca gaagtagtag cgggcattgt 2088301 ctcacttggc aacgacagcc gtgctgcatg gacgatgcat gtagggttag tcatgcctat 2088361 tactgaagtg atcattcatg atctgtacct catggaaatt ctgaaaaagc atagagagct 2088421 tttagaagag agcttcggga aaaatctcat ccagttgcgc cgtaaatttt ctattcactc 2088481 agatttcaaa aaacattatt tggaataatg tttgtcatct cttaccccaa aaacaaggct 2088541 tgtacaaaac aagccttgtt tttttatgca taaacccccc atgctgattt acttctctct 2088601 tttaaaaaat gtgattctgc gcaaactatt tttcagcctg ccgcgtctat cctaggtaac 2088661 agcctacgat atacgtatat tcaaaaagga gccctttatt gcaatgaaga aaaaacaaac 2088721 aacaaaagcg ttgcttgtca catgcataac tgaccataag caagatttct acaggttggc 2088781 tttcagttat gtgaaaaatc aagatgacgc attagatatt gttcaggaat ctataaaaaa 2088841 agcgctgagc tcagttgaaa cggtcaggaa ccctgagacg ataaaaagct ggttttataa 2088901 aattttagta cggacagcca ttgacttttt gcgcaaacaa aaaaagataa gagtgatgga 2088961 cgacgaaacg atagaatttt taagcaaagg aaaggaagac cattacaagg atactgatct 2089021 ccatgaagcg cttgacgaat tgccgtaccg ctataaaacc attattattt tacgtttttt 2089081 tgaagacctc aaattagaag aaattgcgga aattacagga gaaaacacga ataccgtcaa 2089141 aacgcgccta tacagagcat tgaagctgat gcgcattcag ttgacgaagg aggatctttc 2089201 ttaatggata agagattaca gcaattaaga gaagaatata aaaatgttca gattcctaaa 2089261 gaattggata tcattgttga aaaagccctt cagcaagaac caaaaaagaa aagaatcgtt 2089321 atgtggccga catcagcagc aatcgctgca gctattttat tcactgcgct tgttaatatc 2089381 aacccggacg ccgctcaggc tatgtcaaag atccctgtca tcggcaaaat cgtcaaagcg 2089441 atcaccttta ttgaaatcaa agaggaaaaa gaccaatcaa gcattgatgt caaaacacct 2089501 gctttgtccg ggctttctaa taaagagctt gaaaacagca ttaacgagaa atacttgaaa 2089561 gaaagccagc agctgtataa agagtttata cagtccacat ccaaaaacaa aaaagggcat 2089621 ctcagcatct acagtgatta cgagacggtc acagacacgc cagatttact ctctatccgg 2089681 cgcaatattg aaacaacaca agcatcttcc tacacacaaa gccgttatat tacaattgac 2089741 aaaaagaatg atattttact tacattaaaa agcttattca aagatgagcg ctatatcaaa 2089801 gtcatcagtc aaaacatcaa agaacaaatg aaacagcaaa tgaaggaaga tccaaataaa 2089861 atatattggc tcactgacga agatgcagaa ccgttcaaaa cgattcttcc tgatcagacg 2089921 ttttacatta ctgaagacca taaacttgtg atctcatttg acgaatatga agtcgccccc 2089981 ggctatatgg gcgttacaga gtttacaatt ccaaccggcg tcatttcaaa cttgctcgtg 2090041 ggagaacgtt atattcgata aaataaaaac atccatctaa gattatggat gttttctctc 2090101 ttctctattc gaggtcgtaa ccccgctatc aaaaacaacg agaatatttg catactattg 2090161 gaggaatacc catgtatcac aagacacagc atcatcgata cattcctgga cttgatggcc 2090221 ttcgggcttt cgccgtcctg tcagttatca cttatcacct aaatttcaat tgggctaacg 2090281 gtggttttat cggggttgat atcttttttg ttttatccgg atatttgatt acatctattc 2090341 tattaccggc atatggaaat gatatcaatc ttgattttcg ggatttttgg gtgcgccgca 2090401 ttcggcggct tctcccggca gcgtacctta tgatcttttc cactgttgtg tgggtcgtat 2090461 tgtttgatcg agaactattg cacactgtac gtggagatgc gatctcttct ctcttttata 2090521 tgagcaattg gtggtttatt tttcacaagc tatcatattt tgatagtttc ggttccccat 2090581 cacctctaaa aaacctttgg tcgctggcga ttgaagaaca attttatatc atatggccga 2090641 tgtttttagt tgttggaatg tacataatga aaagccgcgc cagattggct gcggtgatat 2090701 cattgcttgt gctttgttca gccgtgatga tgagcgtact gtatgaacct ggcggagatc 2090761 cgagccgcgt ttactatggc acagacactc gttcgtttga acttctcatc ggatgtgcct 2090821 tggctttggt atggccgatg aaaaggctgt cttccaacag gctgccaagc aaactgaagc 2090881 acactttgca cgccactgaa tttttggcat tttgtatttt agtgttgtgt gtctatttca 2090941 cagatgaata cgagcctttt ctttacagag gcggaatgct attcattagc gtgactgccg 2091001 caatccttat tgcatgtgtt tgccatccga gcagcttttt aggcaatctg ctttcatgga 2091061 ggccgcttcg gtggcttgga acgaggtctt acggaattta tctttggcac taccctgtta 2091121 ttgtgttaag cacgccagtt caagaaatcg gaaaccctgt tttttggcat atcgtgctaa 2091181 aggtcattgt gacatgtata cttgccgagc tctcctacca ttttattgag aagccgatac 2091241 ggacacaggg atttaggtca ttttcccgcc gtgtttttat acatagaatc aaggaatgga 2091301 aaacgacatc tgtcatcagc aaaatgtcaa ttggtttcat tattttcgct atacttattt 2091361 ttgcaggcgg gctgtcaggg ctagccggcg agcaaaagca ccctaccaaa tggacctata 2091421 gctcacaaga aacaaatgct gacaccagcc aggcttctgg ggataaaaag aacgctgcag 2091481 cagataaaaa acacaatcct gaacaaaaga caacagattc caatcagggt caaaaggaaa 2091541 acaaagatag tgggcaagag actcataaaa agaaagacac gcaatcccaa cagttgaaaa 2091601 aaccagcaga cactgcgaaa gaagttttag ctataggaga ttccgtcatg cttgatattt 2091661 cttcacacct gcgtcagtca ttttcaaatg tgacgattga tggaaaggta gggagacaaa 2091721 tgtctcaagc tttggaactc gcaagggaat acaagtcttt taatcagccg aacaaggctg 2091781 tcatcattga gcttggaacc aatggctatt ttacaaacag ccaaatcgaa caactgcttc 2091841 aatctttctc aaaagctcat atttatcttg tcaatacacg ggttccccgc caatgggaaa 2091901 gcaaggtaaa tgaatctttg cagcaacagg cccacgcaca tcaaaatgtt acgttagttg 2091961 actggcatac agaagctctt cagcatccgg aatattttac ccctgatggt gttcacttgg 2092021 ttcctaaagg ggcaaaaact ttgactgctc ttattgttca ggcgatgaaa tcgtaaaaaa 2092081 gagatcctat acagatcact tttttacttt agtttctgat cgttgattat gtcttctttc 2092141 agcaaggcag cccttatgtt tacatgccgt ttacgtaagg gtaagccaaa attgaatgga 2092201 gggatgataa tgaaaggaaa tgaagaacat gacatccaaa aagagttgaa acgatatgag 2092261 ctttttttca aaaaacgata taaggttctt tatacagtaa acgattttat catcggtgct 2092321 atgtttctcg ttggaagttt tttctttttt tatgaccggt taatgtcggc agggatatgg 2092381 ctgtttgcga tcggaagttt gctgctgtta atcaggccga ccattcggct gattcatgac 2092441 tttcattacc gtaagcatgt ggaacagcaa ttcaagcatc aatcttcaac agatgactga 2092501 tcttaaggaa taagaaagaa caaaatgcca aaagcctgag tcgaaaatca aaaacaagac 2092561 tttcagacta tttattttta aaaacaaggt aaaaagaact aaacttttgc ctctgcatgc 2092621 cgatatgaat aataaggccg gcgcgatact ccctataaca tccttttcag tagatttcat 2092681 tatcgtgccg gttttctcat atgcaaagca atcccgccaa tcagattggc gggattttat 2092741 attttacatt cctgtccaaa cgtctttcac ataacgtctt tgatcttgca gcttttgcag 2092801 ccatacagct gattcttcct gacttgctgc tttttcagct tcatatgcca atcgcaaagt 2092861 tctctctaca tcaggagcca tttgcgatcc atcaccgcat acgtaaatat gagccccttt 2092921 ttcaatgagt gtcatcaatt tctgcgtatc ttgcttgagc aagtgctgga catatccttt 2092981 tggttcgttt tcgacgcgcg agtagcatcg gcggattgtg accaaaccgt cctgttccgc 2093041 ttgatccagc tcttctctgt aaaggtcgtc atggtccggg cggcggcagc cgaagtataa 2093101 aagtgcttca ccaagggtgc ttccttcctt cttcaaaacc gatcttgcct gaataaagcc 2093161 tctgaatggc gcaattcctg tgcccggccc gaccataatc ataggcgttt caggatcatt 2093221 cggcatctga aatccggact gcggcgtacg aatgaagcaa gctgctgcat cacctgtatt 2093281 caattctgct aaataattag aggcgacacc ccggtattca cctcggccgc tccatgctga 2093341 ggctttcaca actcctaccg tcatgctcac gatatttgca tgaactttcg gtgagcttga 2093401 aatggaatag tatctcggtt ttagtgatgg caaaagtgct aaaaaccgtt caaacggcat 2093461 ttcgcaagca ggataatcct ctaaaaaatc aagcatggta agacgttttg caagtacctg 2093521 ctctttgtaa atgccatcat ctgaaacgag ctgttccagc tctttttgat gcggcggaca 2093581 aactgtataa gaggccagct cccgaagctg aagccttgat gccggttcct gcagctctac 2093641 ataggacgac aataaatcca ctactttgat tggccgatcc atcggcagat gagccatatg 2093701 agcgcttccg cttactttta tcacatgatt ggactgcaaa ccgaatcggc tgagaacccg 2093761 ctgaacaagc tccctgctgt tctttggcag gattccgata tgatcgcctt ctttatatgt 2093821 tttaccagcc ggaatttcca attcaatatg gcgggttgaa cgcgtgctgg cagctgtctg 2093881 gagttctcga ttctctaaca caatcccttc aaacgcgcca tatgctttag caaccggcgt 2093941 ttccgtcgct tcactgagaa aagtaatcga taatgaaggc ctgtcttctt tctgggctat 2094001 ttcgttaata tcaaatgcgt ccatcgtttc cttccagaag cggttttccc aagactcgcg 2094061 gtggctttca aaatcatcgg cggcgtcacc ttccccaatc gctgttaaac gcgatgcccc 2094121 ctttgctttc atcatgtcat caatcaggcg gggaatccgc tgatacgtgc tggcccagct 2094181 ccggtttccg cagccgaata ccgcatagga aacacctttc aattggcctt cctcaagctc 2094241 tttcagccac tctacaaatc cggcagcatt atcaggcggc gccccattat aagaagccgt 2094301 tacaatgacg actgcccctt cttcagggag cttgccgata taatcatcaa gcggagccgt 2094361 ttcagctgta aagcccatct ggcggccttg agcagccagt tcaccggcta ttccctcagc 2094421 tgtcccaaga tttgaaccaa aaagaacaag taaaggtgtg ccgtgtttag gtttggtttc 2094481 ttttggcttt gtttctgctt tgatgtctgc ctgttctttt ctctgtacat tgattgccgc 2094541 tgtttttcgc ggtttcacag taattttaaa atcatccggc ttgatcgtta atgcttcttt 2094601 gatttttagt tcgtagccag tatggtttat caattcaaaa tgctttaata caagaccgag 2094661 aaccattgtc gcttcttgaa gagcaaactg catgccaata caagcgcgct gtccgtttcc 2094721 aaacggctta tacgcatggt gagggatact tgaaggatcc tcaaaccgtt ccggacggaa 2094781 atcttccgca tccggtcccc aagcgttttg atcccggtgc agttttggaa ttaaaacagt 2094841 gactggctgc cctttgctga tcggatattc cccgcctaga acagtatcct ccttcgcata 2094901 tagagaaaaa gccggagctg ttggatacag tctgagggtt tcatttaaaa ccatccgaat 2094961 gtatttgagc tgctggattt gtttatattc aggcgtgtca tccgttaaca cgcgatccgc 2095021 ttcctcctga gcttttttca gtttttccgg atgtgtaagc agacaataaa tcgcaaagga 2095081 tagcaacccg cttgttgtct catgtccagc aattaaaaat gtgatgattt ggtatcgaat 2095141 gttttcgtca tccagcgttt cacccgttac tggatctttg gcataaagca tgagagacaa 2095201 gagatcctta atgttttcat ccggattcgc ctttcgctcc gctatcattc tatcaaccag 2095261 ggagttcatg acttctatat ccttttggaa ctgcagcttc gttttcacca tcattttatc 2095321 ttgcaggccc agtcttttcg attgattcat cgcctctttt aaggcacgga gcatactggt 2095381 gataaacgga tgctgtgaat cacggtaaaa gctgttgaat cgatagttaa acccgcataa 2095441 cccaatcgta tcaagcgtca gacgtgtcat atcgtccgct acatcaattt cttcattagg 2095501 gtttaaccgg ctccactttt gaatcagctg ggttgcgata tccagcatca tagaatgata 2095561 gcctttcatc gctttttgac taaaactcgg cagcaaaatg cggtgggctt tttgccagtt 2095621 cggttcgtgc gtccagcttg taaataagcc atctcccccg aactcacgca ccttttgcaa 2095681 gcctttgcca aggttcttgt caaagcgttt ttcatcacac acttcagcca caagattgtg 2095741 gccggacaca aaaacactgg atactcccgg aaaatcaaaa cggaaaatcg gtcccaattc 2095801 atcagctatc cgccataagg attgagaaag ctgttctttt tccagatgcg gaagattttt 2095861 taaaggtccg tatgttttgg gctgaggtat tgcgcttgcc tgtttcatta acatctccct 2095921 ttcctatttt tgtgatgaat gaagcttaat ggcgtcccag cagcattgtt ccaattcagt 2095981 aattaaatca gtgtccatct ctatatcacc tgtttgaacg agctgatata tcttgagaaa 2096041 cgcccctaat acaatcgcaa ttaacacatt agagggcagg ctgcgaatca cgccttccgc 2096101 ttttccctta ttaaaatagt catcaagcat ttgagtcaga ttttctatca tttttttgct 2096161 tgtatgattt aagtaatgag cgtctttttt ggtttcaaga aaaaaaagcg catagtcgct 2096221 ctctttcgta aactgaacga gacagcaaaa tacgtggtga aagccttctc tgacaggcaa 2096281 ttctgaaacg tcttgcttca gtttttccgt aaatcgctgg atgctttctt gaaacagtac 2096341 gttaacgagt gtttctttgc tgtcaaaata acgatagatc gttcctgtcc ctacatgagc 2096401 acgttcagct atcataggaa tagtggtagc gtcaaaaccc ctttccgtaa aaagtgagac 2096461 tgacgctttc ataatcatgt cgtatttact gctggatgcg gatatcatgt aatctgacaa 2096521 cctccgattc gtttacggaa tgaatattca ttccttttgt tcacaaagaa tgtctgccct 2096581 gtctgatatc acctctttgt tctttcttct gttataagtt tatatgaaaa aaactttttt 2096641 taatataaag tatatgcaaa aaataaaaaa ttaagaaaat atacccaaat cctaatacga 2096701 ggatcttgga tatatttccc gagaaatttt ttatttaaca gccacaatac atagacagga 2096761 agcacgcctg ataacagaaa gatccctgaa atgctggtct ttcagcagtt gaatatacgt 2096821 tttctctttt tcaccggtat ttgtgtcaat actgatataa aaccggccgt caatttgaag 2096881 caccctgtaa atttctctta atgcaagcct aatatcggtg cagctttgaa ccgtatgtaa 2096941 agaaaagact ttattaaagg tacggtcatc aaagggaatg tcctctggat agccatgaaa 2097001 aacctccccg ttccccatgt tctttcgatt cgcacgtgat atctgtctta cctttcgttt 2097061 tgaaggatca atgcttttta ggctaccctt ttttagtttc ttggttatgc ttttaaagac 2097121 agtgccgttt ccaattccaa tttctaaaat tctgtcattt tcttgtatat ctatagagtc 2097181 aatcatcata tgctcaattg ttttggttag cttatatttc cgagaaaata atttccaaaa 2097241 atccgatcgt ttatagagtc tattttctag cattttaaac acctgctttt ggtttcctat 2097301 gtttatttat tatcttaaaa aaataaacat catcttcatt tctaaaagtg aaggaaggta 2097361 ccaactagac ggcaatgtat tgaaaaatgt ttcaatagaa ctaaactttt tcattttttt 2097421 ccgaaaaaaa agcagaaaac ataatgtttt ctgccctctt tctaatgcca atgataaggg 2097481 aatacataca gcctttgctg ctgcattgcc atcagcctct gctgtcggaa tggatttcca 2097541 taaccatgtt tgaaggaatg cggcatggac gcataaccat ggccaatcga cggcagtctt 2097601 ttttgataat cgttcatcat gccatcacct gcctcacaat aacgttgatt tactatatgc 2097661 aggcgcgcat tttcttgaca gctatttcgc taaacttggt ccttctccat tgtataatgc 2097721 atcaatagtt ccattctaag catatgccat tcccccttca gtttttttcg ttgcttttag 2097781 cgccagtttg ttaaataaag atgctttaac tgagactctt tcatttcatc ataaatttgt 2097841 tcaatctgct gttctcgttc gaattcttcc aggcttttaa accgtttttt aatcgttaac 2097901 gttaaaaaga ataggttaat cgtcatatcg ctcaccccct ttcaaagtcc gcatcaagcg 2097961 aaataacccg cggcacaacc cttctgccgc gggcaaataa aaaccgcaga caaaagaaga 2098021 caccaatgcc tctactgcct gcggggagtt gcgtatgtcc gactattccg aatttaatgc 2098081 gtgcgataag catcggttaa ggaaggacac gaactcttcc acaggctgaa taaaccatga 2098141 acttttacat gtgtatcacg tacaggttga cgtcgttgtc tcattgtcat tttggttcag 2098201 cctcctttgc ttttttctta ctttgtaagt atatccacca aattccattt tgtaaacatc 2098261 tttttctaaa aatggacgga aattgtgcaa atcatcgaat ggatttgccc gttggtcatg 2098321 acacctgctt catttctttt ctggagcggt ctttcttatg atatgcaata aaataaatga 2098381 gaccgacaaa tacagctccg ccgatgacat taccgataaa agccggaatg atgtttccga 2098441 tgaactgccc ccacgtgaat gagcctgcaa aaatggcagc aggaatcaca aacatgttgg 2098501 cgacaacgtg ctgaaatccg atagccacaa aagccatgat tgggaaccag atgccaagga 2098561 tttttcctgc tgcgtcttgg gcgccgaaag aaagccacac tgcaagacat acaagccagt 2098621 tacagccgat ggcggaaatg agaaccttgc caaagctcat atcaagcttt ccttgggcaa 2098681 cggcaatcgt tttttctaaa taaggacctg tttcagtcaa tccaaccaaa tgcccgaaaa 2098741 agtaagcaac aaacaatgcg ccgattaagt tcataattgt gacgattccc cagttaatcg 2098801 ctaactcttt tactgatatt tttctcgaaa ataacgccat cgcaactgac atcatattgc 2098861 ctgtgatcag ttcagcgcca gcgagaacga caaggatcag gccgactgga aatactgctg 2098921 caccaatcaa actggacagg ctcccccatt ctttcggaag atcgccaatt accctgatat 2098981 caagcaaata cccaagcgcg ataaatgcac cgcctaaaaa ccccagcaca agcagtgacg 2099041 gcagcgggag ctttattttt ttcatccctg cttcaattgc tgcttccgct atttcatccg 2099101 gttttcgaaa agccataata aaacgcctcc attacttctt cttttctcac agttatgcaa 2099161 gaaaggcaat aaaaaaggca gcactcaaat aacctgtgtc aaaccaggcg tttgaatgct 2099221 gcctaacttg tatgcatacc catacaacaa tatcaagcag tatataagat attgaaagag 2099281 aatatataca gttcgtgcat acattccatt gctttagcct tctataactg tagcaacatc 2099341 atatcaaatg tgacaaattt gtgtcaatga caaatatact agctttgcag agcttctttt 2099401 tgctcatcta tttttcggtc aaaaacaaat acagatacag cgatgttttc ctcaatttta 2099461 atatcagaaa acaaatggac tagcttagct cccataagtt cctccattcc ttccggtgtt 2099521 tgtttggaat aaaggtcttg aattaggctt gtccgggccg catgtaccat ctctcttcct 2099581 tcaggcgtgc gggcaataaa ctgctcgctt gcactcagat ttccgtatag tgttgaaact 2099641 gccatgtttt ctacaaatac agtatgaatt ctctcaggcc cttttccgaa caattctttg 2099701 cgaagttttc gaataatatc attgaattca tgaatttttt tagacatgct gattacccct 2099761 tccgatattg ccttataaag gcttttcccg gttcccctca ggacatttca cttggttaaa 2099821 attttcctgc catattgtat tataataaat atcacattat aataaaagca gtgttgatgg 2099881 atttgtaata ggatcttgtt atgagtctat cgttttataa aaatcaagga ttggtctgtt 2099941 agtaagactt gctagtgaac tattccgcca tgtgtgttta caccttctta gaattaaggg 2100001 caggtgtatc tatacatggc tttttttgac ttcttgaaag aaagatggag gggaatatga 2100061 atatgatgga cgttaagtcg atcagtgtcc gtgtagacgg aacagaaatt caagcacgag 2100121 caggggccac aattttagat attttaaatg aaaacggaat tgagtacccg cagatttgcc 2100181 acgtaccaga ggttgacccg attcaaactt gtgatacttg catagtagag gcaaacggca 2100241 agctggttcg ttcatgcgcg acggttgcag aaaacgggat gtctattgat ctttcaggaa 2100301 atcgagtgaa agaagcgcaa accgaagcga tggaccgcct tcttgaaaat catttgctgt 2100361 attgtacagt ttgcgataac aacaatggaa actgtacgct gcataataca gcggaaatga 2100421 tggggatcga gcatcaaaaa tacccataca cgccaaaaga agatccttct tgcgcggttg 2100481 atatgtctca tcctttttac cgctatgatc caaaccaatg tattgcctgc ggccagtgtg 2100541 ttgaggtctg tcaaaacctt caggtaaatg aaacactctc aatcgactgg gaacgcgaac 2100601 gccctcgcgt catttgggat gagggagttc cgatcaatga atcttcctgt gtcagctgcg 2100661 gtcagtgtgt aacagtatgt ccatgtaatg cactgatgga aaaatcaatg ctcgggcagg 2100721 ctggttttat gacaggcatt aaagaggacg tcatggaacc gatgattgat ctcgtgaaaa 2100781 atgttgaacc ggggtatggc agcatttttg ccatttctga agtcgaagcg gcaatgcgtg 2100841 aaacgagaac gaaaaaaacg aaaactgtat gtacgttctg cggtgtcgga tgttcatttg 2100901 aagtatggac aaaaggacgg gatattttaa agatccagcc tgtttctgat gctccggtta 2100961 acgcaatttc cacatgtgtc aaagggaaat tcggctggga ttttgtcaat tcaaaagagc 2101021 ggatcacaaa gcctttaatc cgtaaaaacg gagcctttgt ggaatcttct tgggaagaag 2101081 ccctcgatct tgtcgcaagc agattaggat caattaaaga gcagtacggt aaaggctctg 2101141 tagggtttat ttcttcttct aaaattacga atgaagaaaa ctacgtcatt caaaaactag 2101201 cgcgtcaggt atttgaaaca aacaacgtcg ataactgctc acgctactgc cagtctcctg 2101261 ctacagacgg attgttccgc actgtcggca tgggcggtga cgccggcacg attaaagata 2101321 ttgccaaagc aggcctggtc atcattgtcg gtgccaatcc ggcggaagga cacccagtgc 2101381 tcgcaacacg cgtcaaacgg gcacacaagc tccacggtca aaaactgatt gttgctgacc 2101441 tgcgtaaaaa tgagatggct gagcgatctg atctgttcat cagccctaaa caaggcacag 2101501 accaagtttg gctgatggct gttacgaaat atatgatcga ccaaggctgg cacgatcagg 2101561 cgtttattga tgagaacgtc aattactttg aagattataa agaaaccctt aaaacgtata 2101621 cgcttgatta tgcagaacgc atcacaggcc tttcaaaaga aaacatcatt caaattgctg 2101681 aaatgattcg tgatgctgac ggcacttgtg tcctttgggg aatgggtgtc acacaaaata 2101741 caggcggttc tgatacatca gcagccattt caaacctgct tctcgctacg ggcaactatc 2101801 gccgtccagg tgccggcgct tatcctctgc gcggacacaa taacgtgcaa ggcgcatgtg 2101861 atatgggaac attgcctggc tggctgccgg gatatcagca tattacagat gacaaagcac 2101921 gcgctaaatt tgaagaggca tatggtgtcg agattgatgg aaagcctggt ttagataata 2101981 ttcaaatgct tcatgccatt gaagaaggaa aaatgaaagc tatgtatctt gtcggtgagg 2102041 atatggcact ggtcgattca aacgcgaacc atgtgcatga tattttatca agccttgatt 2102101 tcttcgtggt acaggacatc ttcctgtcaa gaacagctca atatgctgat gtcgtcttgc 2102161 cggccactcc ttcacttgaa aaagacggaa catttaccaa cacagaacgc cgtgtccagc 2102221 gattgtatca ggcgcttccg acgcttggtg acgcaaaacc ggactggtgg attattcaag 2102281 aggtggcaaa ccgtttagga gcgaattgga attacagcca tccaagtgac attttctctg 2102341 aaatggcgag tctttctcct ctgtttgcca aagcaagcta tgaggtgctt gaaggctgga 2102401 acagcttcct atggggcagc ttcacaggtg aaagcacacc gcttctgtat gaagacggat 2102461 ttaatttccc tgacaaaaaa gcccgctttg ccctttctga ttggaccgag ccagcggcat 2102521 ttccggagga atatgacctt catatcaata acggccggat gctggagcat ttccacgaag 2102581 gaaacatgac aaataaatcg aaaggcatcc aagcgaaagt gccgaatgta ttcgttgaga 2102641 tctcacctga gcttgcacaa gagcgaggtg tttgtgacgg ttcgcttgta cggctcgttt 2102701 ctccgttcgg agcagtcaaa ttgaacgcgc tgatcacaga ccgggtacgg aaaaatgaac 2102761 tctatttgcc aatgaactcg acagacaagg agtcagcgat taacttcttg acgggccctg 2102821 cagctgataa acggacgaac acgcctgctt ataaacagac aaaggtccgc atggaagtgc 2102881 ttggcggctg tgaaacagcg ccgcttccaa aaacaaatcc gcgcaacaaa aaacggcatc 2102941 cgcaaaacgg agtcgaagca gaaagaaaat ggaaccgccc tggctatgta catctgactg 2103001 attaaacgat aggaggaaaa cgaatggcca ctccgattac gacgatcaaa aaagaaacaa 2103061 aaacagctga gcaaattaag cttgaaaaaa tagaagaact gaaagagctg ctggcggaaa 2103121 atgaggacgc cgtctctaaa acgatgacgt taatgaatga actcaatgat cttggaattt 2103181 ttgatgcggc aacaagcatg ctcagagcga aggaagacat tgccaagatt gcgcttggcc 2103241 aagtttcccg cgagcctgtc accaacctca tcaacacgat gatggccgcc ggaggcgcat 2103301 tgacaaaagc cgatcctgag tttacagcaa agcttttaga aagcgtaatg gctgggactg 2103361 aacaggcaca aagcttttta aaagaagaca agaaagtcgg gattctcgac ctgttaaaag 2103421 caatgaacga tcctgacatc aacagagccg tcgggttcgg ccttcagttt ttaaaaggca 2103481 tgggaaaaga acttcgagaa caataacaga aaaacagcca tctctgatga tggctgtttt 2103541 tttattcgtc ggcttcttcc agacgcttct tgtaaataag tgaacggtca gcgcaaaaga 2103601 aggcaccggc taaaaatacg caatccgcta aaaacatcgt cgatttctgg cctaatgtta 2103661 agccttgatc agggagaact gcgcctatat ataaaaaagt gctgactgca agcaatgtaa 2103721 aagcaaaatg cttgtagtct tcttttaaag atttcattct atttttgttc aaaagaatca 2103781 cctgccagat tcatagtata cgactattat aatataatcc ggcggcttac agagaaagta 2103841 attctatcca tttgttatat attttcaagc gcttggccga tatcttccaa caagtcttcc 2103901 gcatcttcaa ttcctacaga aattctgatc aagccgtccg taatgccgag ctcaagccgg 2103961 cgttctctcg gaatagaggc atgtgtcatt cttgcaggaa cagaaattaa gctttcaacc 2104021 gcccccaggc tttcagcaat ggtaaacagt ttcagatttc ctaaaaacgc atcaacccgt 2104081 tcttcactgc caatatcaaa ggagatcatg ccgccgaagc ccgctccttg cgtttttgca 2104141 agctcatgtc cgggatgatt tgaagaacca gggtaatata acgtttggac agcagggtga 2104201 ttctcaagaa agcttgcgat tttccgcgca ttttgatcga tcgcttccat tctgagtccc 2104261 aacgttttga ttcctctcat taacagccag gaatcttgag ggccgagcac gccgcctgtg 2104321 gagttttgca caaaatgcag ctcttctcca agctctttcg aagctgtcac aactaaacct 2104381 ccgacgacat cactgtgtcc gccaagatat tttgtcgcac tgtgcagtac gatatcagcg 2104441 cctaaagtaa gcggctgttg aaaataagga gtattaaagg tattgtctac gataagcaga 2104501 acacccgctt tttttgcgat atcagccatg agcgtcaggt cggtgatttt gagcaacggg 2104561 tttgtcggtg tttcaatata aattgctttt gtattagggc gaatcgcttt ttcaacttct 2104621 tccctgctgc tcgtatcaac aaatgttgat tcaatgccaa gacggttaag cacctttgtc 2104681 atcacgcgat atgttccgcc gtacacatca tcagtcaaca cgacatgatc tccgctgtta 2104741 aacagcatca taaccgctgt aatggcagcc attcctgagc tgaacgcata gcctgcttcc 2104801 ccgctttcca gttctgtcac aagtgcttcg agagcggttc gagtcggatt ggccgttctt 2104861 gaatactcgt agcctgtatg ctgccctgct ttcggctgct tgtacgtgct tacttgataa 2104921 atcggcacgg aaactgcgcc tgttttctca tcacctgtga ttccgccatg tatcatcaat 2104981 gtttttttct tcatatcaga tgcctccttc gtatatttgt ttgctgatat atcgatcgct 2105041 gctgtcagga aatactgtga caatgttagt tccagcggat gcttttttcg cttcctccaa 2105101 tgccgcataa agcgctgcac ctgaagagct tccgatcagc aggccttctt tttctgccgc 2105161 ttctttcaca agtctaaacg cattctcatc tgttacggtg tagatctcgt caaaatggct 2105221 cttatccata taatcgggga taaactccat gccgatgccc tctgttttat gagcgtgggg 2105281 ctctcctccg tttaaaatcg agcccaccgg ttcaacaatc accgttttga ctgctggatt 2105341 tttttctttt aagaaggaag ctgtccctgc gaatgtgcct cctgatcctg cccctgcgac 2105401 aaatgtatga atattcccgt caagcgcttc ccacatttca ggtccaagcg tcttatagta 2105461 agtcgatgga tttactcggt ttttaaattg caaaacgcaa taagaatttt caatttcagt 2105521 ctccagctga atggcttttt gaatggctcc ctgcattccg tcttgacgcg gtgtatgaat 2105581 gattgatgcg ccaagcgctt gcataatttg ctgtttctct ctgctgaaat gttcagggac 2105641 acagaaaatc gctttcagcc catattttct ggcacttaac gcaaggccga tccctgtatt 2105701 gcctgccgta gcttctataa tcactccgcc gggtttcact ttgcctgaat cgagcgcgtc 2105761 acgaatcagc atatctccca gtctgtcttt gatgcttccc cctggattca tcatttcaag 2105821 cttggcatac accgcgactc cttctggaac atcaaagttc ttcaagcgga gaagcggtgt 2105881 attcccaatc agctcggtaa tgtccgtaat cactgtcata tatgtcctcc tccttaatag 2105941 aggttgtttt tagagaaaaa cggaggagaa cgttctcccc gttttaatga attcgtttga 2106001 tcacctttaa cacaagctct gttgaatgaa cagccgcctg ctctaaaaat tggtcaaatg 2106061 aaacatgtga ttctttgcct gcgatatctg ataacgctct gatgacgaca aacggcgttt 2106121 taaattgatg gcatacttga gccactgccg cagcctccat ttcaaccgcg tacagatcag 2106181 aaaatctcgc acgcacctct tcaacccgct tcggatcgtt catgaaagaa tcgcctgttg 2106241 caatcgttcc ttttgcaacc tgaatgccgt cgagttcaga taccgcttct tcagtgatgc 2106301 tgatcagctt ttcatccgcc gcataagcag ccggaagacc cggcacttgg ccgtattcat 2106361 agtcaaaagc cgttacgtct acatcatggt ggcgaacgtc agtggaaatg acgacatccc 2106421 ctacattcaa tgtatgatga aatccgccgg ctgagcctgt gttaatgaca taatcaggct 2106481 tgtaacggtc aagcagaagc gtcgtgctga tagcagcatt tacttttcca attcctgatt 2106541 ttaaaagaat cacttcagtt ccttcatatt cgcctgttgt aaattcacag tgtgcgatcg 2106601 tttctgtttt tgcattttca agtttgtttc ttaagatggt aacttcctct tccattgctc 2106661 cgatgactgc tagtctcatc tattcacatt cccttcactt taccgtttga tcgcctccat 2106721 tatccacacg aagtcgtttt gctgagtgaa tcggactgca aaaccttcag ctgtaaacat 2106781 ttctttcaac gcatccaatg taggataatg ctctgtctct aaatcatttg caagctgata 2106841 aaagccttga gaacgggctt tatcgatagc ctgttgatac gcttgcgcat tttcaaagac 2106901 ggtatcggca aacactattt tatcatgcaa gtgaaggtat ttgccatatt gctttatggc 2106961 agcccgcttt tcttcgtcag tcaaatgatg aaaagcatat gaactgacaa tcgtatcagc 2107021 ctgaaatggc ggctcaggga atgtcaggaa gtctccatca acgatttccg tcctgcctga 2107081 gagcttgtca gaagccagtt tacgcattgc tggagaaggt tcgattccaa atacagtttt 2107141 gcctgcatcg agcagcttag ctgtcaaatt cccggtcccc gggccaaatt ctaacacatg 2107201 cgttccagat tttctgacga tggcatcaag gatatgatcg tagcctctga acgcttcttt 2107261 atactgaata tctaaacctt gtactgtttg atcataagtt gctgcccaat cttcaaagag 2107321 agggataaat tcacggccca tatttgtcac actccatatt taataattcc tataagtata 2107381 ctatggatta atgatggaac agttcctata ataccacata ttctgaaaag caggtactaa 2107441 aacactttgt gtattttatg ccatctcata ttgcgcattg accgcaaaaa agcttatact 2107501 tcatatgact tgtgaaagct ggagggtcaa gacatgaatt ttcaattaga tctgattaaa 2107561 gacaaagtgg aattttttga agcggcttca ttgcaggagc ttgaaaagaa aatcaataca 2107621 caaattgaaa acaataaagc catcatgctc cgggtgaaat ctgtttcaca ccaaactctt 2107681 gtggcagaag gaagaatatt gtacagcgcg gtggttcatt tctcagctga agcctaaaac 2107741 aaaagcagcc ggttttaacc cggctgcttt tgtttatttt agcttttcta cttttgtcgg 2107801 cttccagcct ttttcatcga cccatgtaat cgtgacttga tatttattcc cagtcgcctt 2107861 gtccaaaatc ttgcctttgg catcctgagg gctgccgtta tttccaagcc agagcaccgt 2107921 catgttatct gttgagacac cagttgcgta cgaaatggct ttcagcatct cagcccagtc 2107981 ttgtgagctt gaatcataag tagcggcatg ctcgccagtc tgctcagttc cgactgcttt 2108041 ccagtcagga ttttcatacg ttttttccac atcgctcgat gagccgcctt ctgttacttt 2108101 tgcatcttta agcccgtcac cggctgaatc tgagcttgaa tctgaatcag agtcatcttt 2108161 tttagaagaa gaatcatctt ttttggaatc agagtcagaa gacttctcag aatccttttc 2108221 gctgtcagat gtatctttct tgctgtcttt tatatcctca tccgatttct tttccgtctt 2108281 tcctgaagcc ggagattcct gtttttgcgc cgtttcagaa tccttgctga catctttgct 2108341 agaaggactg ttaatgaaga gattcgctgc tactacgaca attagtatgg atacgattgc 2108401 gattaaaatg ttaagcacta aattggcttt tctgcgttta tcacgatttt cataacgaga 2108461 ttgattattg ctcaataatt ctgcactcct ttatccctct tggctcagca tatattttaa 2108521 catgtgctga gaagttgttc tatttctgat tgatttcaat ttcgtgtact tttttaacaa 2108581 tatcataaaa caccgaattt gtcagagcct tatctcccgg tgtatccatg tgtaaaacaa 2108641 ctagagcgta tttcggctta tccgcgggaa aatatccggc aaaccatttt tcgtagagcg 2108701 tttccttctc ttttgaaagc ttgcctgtct gggctgtgcc cgacttccct gctacagtat 2108761 acggaagatc ttgaaacctt ctgcccgttc cggaaggaga ttctactacc cgccgcagta 2108821 ttttttgaag ctgctgtgac gtatatttgt ctatcgtttc ccctttgagc ttctgatctt 2108881 taaacgtaac gagcgttgtg ccgttcttat actcaatttg ttcggcaatt ttcacctgcc 2108941 gtttttctcc gccgcgggcg attgtcgcca tcatattggc tacctccagc ggcgttacct 2109001 ttacattttt ctgcccgatt gctgtttgcg caatggcttt tttgactgat ttgtcttttt 2109061 catcccccca aatcacgccg cttttttcgt tatacagctg gcggaaatcg gtttcgtggt 2109121 acagttttcc ctcccagcct gcccgatcag tgagagccag cttctcggac atatcttcaa 2109181 taaccgagct gtcttttttc attaattgtt ctgcaagact cgtaaatgtg taattacagc 2109241 tttgggcaaa actttcatca aaagacaagg tgcctttgtc gtcccccggt tccccgtaca 2109301 ggtttaaatt gcaattaaag gtttgactag gcttcaccat attattttcg attgcagctg 2109361 cggcaatgac tgttttaaaa actgatccgg gatagattgg cgtcagcata taattttgaa 2109421 gtgtgttttg ccgggacacg tctgcatctg gtttgcttac aattcccaga acactgctat 2109481 tttcgatgtc cagcagcaca gctcctccct ttttcagccc ctgttcatcc aatacctcct 2109541 ccatcgcttt ttgaatgctt tgatcgatcg ttgttttgat ctggagcgga taaaatgtat 2109601 tggcttcagc tgtatatttg acgtccatgc caaacaaagg gtttcctttt ccgtccacat 2109661 gatataaaag ctttgtgtct tgttccggaa gcaaaaactc gtcaaatgtc cgttctaaac 2109721 cggttgttcc gatttctgtt gtaatcggaa ggctctcctt gtcaggatat ttcttgcgaa 2109781 gcagcgccgg atcttggttc gtgctcccta tcgtatgtga agcaaggctg ggcttgtctt 2109841 cattctccat atatacgccg taaatgccgg gatatttcaa agaattgatt tttgtgatag 2109901 attgttttga aagtgttttg attttctttt gctgcaaaat gaccggtttt tttgcctgac 2109961 ctagtgtctg gcgcaaatca tcttcagaca tgccgaggat gtccgcaact tttttgatcg 2110021 gccaatcctg cgtcagcaga aaagggaaca aaacaaccgc aggctcgctt tgtcctgtca 2110081 gcgcccgccc gtttcgatct aaaaaagagc ctcttccatc tgaaatgagc acttcctccg 2110141 tccgctgttt cacactttct tgaatcaaat taattttctt tttagaaaat gattctgtga 2110201 aaaacagctg gatttctgca agtctcagca gaagcagaaa aaatacaatc aaaaaagcga 2110261 tgactgccag cttcattcgt ttcgatatct tcataaaaaa acacctcacc cacattgtgg 2110321 acgaggtgtt tcgctgctaa acagatatta tgaaattttc acaattttca cgagcatttc 2110381 tccgcccggt gtttgtactg tgacttcttc atctactttt ttgcccaaga ggctttttgc 2110441 gatcggtgaa tcgtttgaga ttttcccttc aaacgggtca gcttccgcgc ttccgacgat 2110501 cgtatatgat tcttcatcac cgtcaggcag ttcgacgaaa gtgacggttt tacccaaacc 2110561 gacaacgtta gagccgccgt catcttcaat gattttcgca ttgcgaatca tattttcaag 2110621 agtcgtcacg cggccctcta caaatgcctg ctcttctttc gctgaatcgt attcagagtt 2110681 ctcggaaagg tctccgaagc ttctcgcaat tttgattcgc tctactactt cttttcgttt 2110741 aaccgttttc aaatattcta attcttgttc aagtttttgt tttccttctg cagtcatagg 2110801 aaaaactttc tcttgtgcca tgtcccttca ctccttctgg ttgtccctca acatcttcga 2110861 ttatgtatga gagcataaac taaaaaatac aagaatgaga acacagggca gtcctcgttc 2110921 ttctctccca tataggtact gtttatctta aactgaatcg tgtcgttctg caaatatttc 2110981 gcgtttataa acagggaaag aagggaattc gcacattccc ttcctgccta tacataatat 2111041 ggtcagagtt atttatgtct atgctatggt attacaaaat cgcgttttgt tcaagaatgg 2111101 tttgaatttt tgtgaccatc agatcaattg cgacgtgatt ctgaccgcct tccgggataa 2111161 taatatcagc gtatcgtttc gtcggctcga cgaattggtt atgcatcgga cggaccactg 2111221 acacatattg ttcaatgaca gaatcaatag agcgtccgcg ctcattaata tctctcataa 2111281 tccgtctgat gatacgcaag tcagcgtccg tatcaacata aagcttgata tccatcagat 2111341 cacgaagcct tttgtcttca agaacaagaa tgccttcaag gataataaca tcctttggct 2111401 ctacgtgaac cgtttcttct gaacgtgtgt gaagcttata gtcataaatc ggcttttcaa 2111461 tcgggcggta attcaataga tcttgaatat gctcgattaa atagtcatta tcaaacgcaa 2111521 gcggatgatc atagtttgtg ttcagccttt cttcaaacgg aagatggctt tggtctttat 2111581 aataaaggtc ctgctggatc attaaaattg agtgtccttt aaactgttca taaatggacc 2111641 gtgtgacact cgtttttcct gaaccggaac ctcctgcgat tccaatgact actggattct 2111701 tacccatggg ctgttacttc ccctttctca tcatgttgct cggataaatc tttttgtcta 2111761 gtttgaattt gacaatttgc aggggatggc gggcagcatc tagctcattt ccgtcttcgt 2111821 cccaaatggt ttcaatcgta tgtgtaaagt tttcgatttc tggaccgaaa aattccactt 2111881 cgtcgccttt tttgaagaaa ttgcgctgct gaagcgtgac catttgtgta tcttcatcat 2111941 aattcagcac taagccgaca aaatcatatg tcgttttctt ggcgtgttcg ccgaacattt 2112001 gctcttcata gcctggcgtt ccttcaaaga aagctgtcgc agtgtccctg ttggcgcact 2112061 tatcaagctc ttcaagccat tctttttgaa tcacaaagtt ttctggatca gcgcaataag 2112121 catcgattac tttgcggtat acgctgacaa cagttgctac atagtgaatg gatttcatgc 2112181 ggccttcaat ctttaagctg tcgatcccca tttcaatcat ttttggaatg gattcaatca 2112241 gcttcaaatc tttcgggctc atcgcaaatg gtgcatcttc ttcaccatac aaagcaacgg 2112301 cgttggcacc gtctgtttgg tagagatcat aatcccagcg gcatgactgg cagcagcctc 2112361 cgcggttgga atcccgcgct gtcatgtgat tgctcagcac gcagcggccg gaatatgcaa 2112421 tacacattgc gccatgaatg aaggattcga tttcgatatc taccttttct ttcatttctc 2112481 tgatttcaag agcgctagtt tcacgtgcca gcacgacgcg gtcgagacct tcttccttcc 2112541 agaactggac agccttccag tttgaaagag actgctgtgt gctcaagtga acctcaacat 2112601 tcggcgccac tctgcggcat gtttcaataa taagcggatc tgccacaata ataccggcaa 2112661 cgttggcgtc tccaagcgct tttaaatagt cttcaagccc gtccatgttt tcattatgag 2112721 cgaaaatatt cgttgttacg tagatcttcg cgccatattt ctttgcgaat tcaacgcctt 2112781 ctgcaatttc ttcgatcgta aagttatcgg cattcgagcg aagcccgtat tcctgtcccc 2112841 cgataaagac cgcgtccgct ccgtaatgaa cagcgatttt cagcttttca agattacccg 2112901 caggtgcgag aagctccggc tttttcgtaa tcacacgctt tccattaacg attgtggata 2112961 ttttatcatt tacggcagtc atagcttaac ctccttttga ttaataaacc gtttccttga 2113021 agaagaatcc ggtatcaatt tttctgttta ctggctggat gctttcaatg cgttcgatcc 2113081 agtcttcttt tttcgcttcg tattcgtcac ggttttccac gcacaaatca attgcttctc 2113141 tgtacatttt ggtgacttct attaggtatt caggcatttt caaaacacca tcgattttga 2113201 aagaatcaat tccggcatct atcaattcct cgagctcatc aatgatgcac acatcgttcg 2113261 ggctcatgat gtgagtgccg ttttcatctt cgaaaatcgg atatttatta tcgcgttctt 2113321 tatcgtgtaa aaacatgcct gattcttttt tctttctttc aatgtccatg actttgccct 2113381 gatattcaaa atagtttcca atcaaagaac gcttcgattg gaacatgcac gtcattccat 2113441 gcacctggat ttcaatttcg acttcagcat tttctttaat ctcaacaatg ctgtccatgt 2113501 ttaattctct ggcaagcaca gaacgcgccg cacccttgcg tccccagtag ttgcatgtat 2113561 aatagttggt gcctgtcgtt tctgtgctcc aatgaagctt cagatcaggc gcagattcac 2113621 gggcagccat cagcacggca ggatcgccga ataccgctgc atcgacaccg gcttctgcta 2113681 agaaagccag atattcgcca agctcaccca ctttatcatt atggaaaatt gcatttacag 2113741 caacgtatac ttttgcccct tctttgtgag caatctctac ggcttttgtt acatcttcac 2113801 gagaaaattc tccggctaat ctcaagccgt atctctgttc cccaactaaa aacgcagttg 2113861 ccccagcctg tatgagcggc aaaatgtccg ctgtactcgt cggcgtcact aagagctctg 2113921 gttttttcat gacgttcacc tcttcttttt actaatcgca agtccgtccc cgacaggaat 2113981 aatcgcagtt tgataatccg gatgattcat cagccaatga ttatattcat caattttggc 2114041 tacaagcctg cgccttctct tcggttctat tttgctgtaa tcctctgcca ccagaccttt 2114101 aaacagcacg ttgtctgtta taatcacccc gtccggtgaa agcatcggtt catataaatg 2114161 aaaaaagttt tgatactgac cttttgcagc gtcaataaaa atgacatcgt aaggcgcggt 2114221 tacatgaacg gcgtcggcta attcaagcgc atctccgtaa aaaacatgaa tccggtcatc 2114281 aagctgaaat tccttgatat tgtttaccgc ttcttcatgc cgtttctcat tgcgttcaat 2114341 tgtatatatt tcagcagacg gcagttccag agccattcga atggctgaat aaccaatggc 2114401 cgttccgatt tctagtattt ttttcggctg tttcacagac aaaatttgaa gcagcacctc 2114461 catgcccgct ttttccataa tcgggacatg atgttcttct gcatatgctt caagtctctt 2114521 cacgttatcc ggccgaggct ttaataatgc ttctatatag tcatttattt gttcataccg 2114581 gtcagtcact acaaacagcc tcccgttcta aaaaggagtg ccccagtctt atgcgcagga 2114641 cactctctga atacatcatg atacatcggt aaacaacccg atatatttta tcataaaacc 2114701 ttgcggaaag cgaacaaaag gagagctttt tgctctcctt ttatttctca ttttttgagg 2114761 aaatgtattt ttcttttgct ttattatgct cttttagcgt ttttgtaaat acgacctcac 2114821 catttgattt ggccaagaaa tacagatagt ccgttttatc cggatgcagc gctgcttccc 2114881 atgatgacat gccggcattg gcaatcggcc ctggcgtcag ccctgtgttt ttatacgtat 2114941 tgtatggtga atcgatttcc agatccttat aaagaacccg atctttatgc ttgcctgccg 2115001 cgtacaggac ggtcggatct gtttggagcg gcattttctt tttcaggcgg ttataaaaga 2115061 cgctcgcaat tttatggcgg tcggcttttt cagtcgcttc ttcttctatc aaagaagcca 2115121 ttgtcagcag cttatgcaca gaaactttgt ttttcttcat ttctgattta tatgtttcca 2115181 cataagaatt tgtctgctta atcattgcct tgataatgtc ttcaagtgat gtgtccggat 2115241 cgttaaaagg gtatgtagcc gggaataggt acccttcaag cgggtgctta atgtttttat 2115301 tgaaaacatc atttgtcaca gtgtccggga attctttctt cagctgattg ataaatgttt 2115361 catcgtccag cttcgctatg acttgttttt tagagtattt tgtttcatca gcaatagcag 2115421 ccgcgatttg ggtcagctgt gctccctcag tcactgtgat ttgaaaagcg taacctgtag 2115481 ccccgcttgt cagcttctga ataatggcat ctaaatccat acctttattc agatggtaga 2115541 atccggcctg aaacccggaa gcacctttat atttcacata gtactgaaac gccttctcgc 2115601 tttttatgac atcatttttc tttaatatcg atgcgatggc tgaaacagac gaaccgctcg 2115661 gaatgttaat attaactgtc gttttactgt ctttttcaac aggttcaagc aatgatttcc 2115721 catataaaaa tgccccgcca atgatgagaa acagcacaac aatggaagac agtatgattc 2115781 tttttttatt aaaaaacgat tttttttgct gattgatata cattaggtct cctcccatca 2115841 gctcttatac tacatgattc attgtatttc ggcaatttat tacaaaaaga ggcctgcata 2115901 aagcagaaaa aagccggagc agtatagctc cggctttggt ttggcgcgat gttttactct 2115961 tcgtcttcgt ccgctaagaa tgtgtttagt gtttcttcga tcatatccca ttcttcgtca 2116021 gtttcaatcg ggaatagctc accgttttca ccgtcttcgt ttggcgtgaa gctggaagca 2116081 agaatttcta cttcttcgtc atcttttgat tcgattggat agtacaagac ataagatttg 2116141 ccaaactctt cattttcaaa tgtaaacagc acttcacaaa gctgttcatt tccttgatcg 2116201 tcaacaattg taatattttt ttcgccgtgt tccattttct tcacctctgg ctttaattta 2116261 agctgtcaag atatccttgt aaaatcataa cagccgccat tttatcaatg actttttttc 2116321 gtttttgcct gctgacgtca gctgcaatca gcattttttc agccgccatt gtggtaagac 2116381 gctcgtccca cagcacaaca ggaacattgt acgttgtttc aagcactttc gcaaatgttt 2116441 ggctggcttc gcctctcggg ccgactgttc cgttcatgtt cttaggaaag ccgagcacga 2116501 ttttatctat agtatagtcc tttatcagtt cagataaacg ggataaacca taatcgcctt 2116561 ctgcttcatt tatctttatg gtctcaatgc cttgagcagt ccagcccatt tcatcgctca 2116621 gagctacacc gagtgttttg gttcctaaat cgagtcctaa tattctcatt ctttatttac 2116681 gcctctttat gctgttctaa ataagacttt accaattcct cgattaattc gtctctttca 2116741 agtttgcgaa ttaaattgcg agcgtcacga tgcctaggaa tataagcggg atcacctgac 2116801 agcaagtatc cgacaatctg gttgattgga ttgtagccct tttcctgaag cgcgtcatac 2116861 actgtaatca gcacctcatt tacgttagtc tcagcagaat catcggagaa attaaatttc 2116921 atcgttttat caaacgagct caccgttttg cacctctttc ccaaattcgc aggcaaagtt 2116981 cagcctgggg tcctaatctt accatcattc tacactacat gggcgaatta taaaacggat 2117041 ttcacccaat cttctacaga agccaaagct tcttctaatt tttccggctg tttaccgcct 2117101 gcctgcgcca tgtccggacg gcctccgccg cctccgccgc aaacttccgc agcttgttta 2117161 accagcttgc cggcgtgaag tcctttctca atgaggtcct ttgtgactcc ggcagagata 2117221 ttaactttat cgttttgtac cgcaccaagc acgatcaccg cagagccaag ctttgctttg 2117281 agttcatcga ccatagtgcg gagatgattc atgtcttttg catttacttt tgccgcaagc 2117341 acgtttacgc cgtcaacttc ttttactttc gacaggattg ctcctgcttc cacgttgcct 2117401 agttttgcaa gaagagattc attttctctt tgtgcatcct tcagttcagc ctgcagagcc 2117461 gcgacccgtt tcggcacttc tttgatattt gttttcagct cgtcagcggt ctgcttcaat 2117521 acagaaatct ggctgttcat ttcgacgtaa gcgccttgtc ccgttacagc ttcaatccgt 2117581 cttgtgcctg ctccgattcc ggattcagaa acgattttaa acaagccgat ttctgctgta 2117641 tttctgacgt ggcagccgcc gcacagctct aagctgtaat ctccaacttg aacgacacgg 2117701 acaatatcgc catatttttc gccgaacagt gccatcgcac ccatttcttt tgcttcagcg 2117761 atcggtttca aatcaatgct gaccgggatg ctcgcccaga tcttttcgtt tacgattctt 2117821 tcaatttgtt cgagctcttc ttttgtcact tggccaaagt gcgagaagtc aaaacgaagg 2117881 cggttttccg ttacaagaga gcccgcctga ttgacatgag ttccaagaac atcttttaga 2117941 gcctgatgca ataaatgcgt tgccgtgtgg tttttaatga cgccgcttct catatggtct 2118001 tcaacttcag ccgtaacatg caggcctttt tgaacagtac cgctctccac aacaccttca 2118061 tgcacatgct ggccgttcgg cgctttttga acatctttaa ttcttacaac tgcctgctcg 2118121 cttcggagat agcctttgtc gccgatttgg ccgccgcttt ctgcatagaa cggtgtttca 2118181 tcaagaatga tttgaacgct ttctccttca tgagcctctt cgattaattg gccgtcctga 2118241 agaagcacaa tgatattggc atcagctttg gtttgagagt agccgacaaa tgtgctttca 2118301 actgtcacgt cgcgcagtgc gccgccctgc acctgcatgc tgccgacatc ctggcgggcg 2118361 tttcttgccc gttcacgctg ctggttcatt tcctcctcaa agccctcatg gtcaaccgtc 2118421 atgttctcgt cttctgcgta ttcttcagtc aattcaaccg ggaatccata cgtatcatac 2118481 agtttaaaca catcagcacc tgagataacg ctgctgccct tgtctttttc ttttttgatc 2118541 atttctgaca ggatcgcaag cccttcatta agggtctcat ggaagcgttc ttcctcggtt 2118601 ttaatgactt ttgcgatgaa atccgctttc tctttcactt caggatagaa atcagccatg 2118661 atttctgcga caaccggcac taaatcaaac atgaacggac gatggatgtt gatcgttttg 2118721 gcataacgca cggcacggcg taataagcgt cttaatacat agccgcggcc ttcatttgac 2118781 ggcagcgcac cgtcactgac agcaaaggca accgttctga tatggtcagc aatcacttta 2118841 aacgcagtgt ctttcacatt gtctttgcca tatgtttcac cagaaatcga ttctgttgct 2118901 ttaatgatcg gaacaaacaa atcggtgtca aagtttgtcg gaacattctg gatgacagac 2118961 accattcttt caagacccat gcctgtatca atatttttct ttggaagcgg tgtgtacgtg 2119021 ccgtcagggt tatggttgaa ctctgagaac acaaggttcc atacttccag gtaacggtcg 2119081 ttttccccgc ctgggtaaag ctccggatct tctggatcat taccgtatgc ttcaccgcgg 2119141 tcgtaaaaga tttccgtatt cggtccgctc ggcccttcac cgatatccca gaagttccct 2119201 tccagacgga taattctttc ttcaggaata ccgatttttt tcgcccaaaa ctcatatgcc 2119261 tcttcatctt caggatgaac cgtaacagag agaagctctt tgtcgaagcc aatccacttg 2119321 tcgctcgtta aaaactccca agcccatgta atggcttctt ctttgaaata atcgccgatg 2119381 gaaaagtttc cgagcatttc aaagaaagtg tgatggcgcg cagttttacc tacattttct 2119441 atatcgtttg ttctgatcgc tttttgagcg tttacgattc ttggattttc cggcacgaca 2119501 cggccgtcaa aatatttttt cagcgtcgca acaccgctgt tgatccaaag cagtgaagga 2119561 tcctcatgag gcactaatga cgcgcttggc tctaccgcat gtcctttttc tttaaagaaa 2119621 tccaaaaaca tttgacgcac ttccgcagaa gttaagtgtt tcattgtatt tcctcctcta 2119681 taaaaatcga aattctcttc agtgacagca aaaaagccct ccccctatgc aaaccaacgt 2119741 ttacacaggg acgagagctg tctcgcggta ccaccctgat tacgggcatt catgcgcccg 2119801 tcacctttaa ccctgtaacg caggataagc ggcagtgatt aactgcactc aggattagct 2119861 tcctccgatc ttctgataaa gctcctttca gcttatggag cttctctctt taacagggct 2119921 tcggcgtact cagatccgtc actcgagatt cgtatgtatt ctacgagaaa ttatagacaa 2119981 gcggcacgcc gatgtcaatg ctccgtcctc atccgcaaaa aatggatcat cattactttt 2120041 aaaacagccg tcgcaggaac agccagaatc atcccgacga tacccgcaag ctcccctccg 2120101 gcaaggagtg caagcatgat aacgaccgga tgcattttaa ggcttctgcc gacaatgaac 2120161 ggactgagga tatttccttc cataaactgc agaataaaca ccgtaatcac cacaacaaga 2120221 accgccttga ctgagatcgt catcgcaatt aacaacgcag gaacagctcc gatgaaaggg 2120281 ccaaaatacg ggatgacatt cgttacccca gagataaggc caagtatcag cggatacgga 2120341 agcccaaata cccagaacga aatgcctgca atcacgccaa gaatcaagca gaccaaaagc 2120401 tggccgcgga tataatcgcc aagcgaatca tccacatccc gcaaaaaggc gctgccccgc 2120461 tttctccacg acttcggagt caagtaccat actgtctttt tcattaactc aatgtccttc 2120521 accatataaa acacgagaaa agggattgtt gcagcaatta agaagtaatc aagcacattg 2120581 cggatcccgc tgatcgcacc ctcgatcgtt cccgcaaaaa acgcctccgt ctggcggatc 2120641 attttatcta tacggtgatg cataccatca ggccagtcat ccgtatggtt atgcacatga 2120701 agaagaagcc cgttatacgt ttcggcaaac atgggtatat tttctgacaa atccgtcagc 2120761 tgcacgatta aaacaggcac ccctttatac aacgcccagc caatcccgcc aaaaaaaaga 2120821 acataaatga ccaagatgct caaagtccta ggcaatcctt tgccatgcag ccattctgtg 2120881 accggaagca ataaataaga tataaaaata gaaatgatca agggaataaa gatcgttttt 2120941 atgacgagcc aaaagggtga ccataacata tcaagcataa aaaagacata gactgttaac 2121001 agaaccagca aacaaatagc cacccacaac aaaagctgca ccggtttttg gagcatctgc 2121061 tttcacctca cctatatctt ttgaggttta caaggaatta ttctttatgt ttctttagtc 2121121 agtcagaagt catggacatt ttttcacttt taattttcag aaaagtttga tcatttactt 2121181 tttggtcaaa ttttctgata ggaggattgc gatgatcaca tttcaaaatg taaacaagca 2121241 ttacggagat tttcacgtgt taaaacaaat taatcttcaa atcgaaaaag gtgaagtcgt 2121301 tgttatcatc ggcccatccg gttccggtaa aagcacattg ctcagatgca tcaacagact 2121361 tgagtcgatc aatgagggag tgcttacagt aaacggcacc gccattaacg acagaaaaac 2121421 tgatatcaat caagtgcggc aaaatatcgg gatggtgttt cagcactttc atttatatcc 2121481 gcataaaaca gtgctgcaga acatcatgct ggctccggta aaagtgctta gacaatcacc 2121541 tgaacaagca aaggaaacgg cgcggtacta tcttgaaaaa gtcggcatcc cagacaaggc 2121601 tgacgcctat ccttcccagc tttccggcgg gcagcagcag cgtgttgcca tcgcaagagg 2121661 actggcgatg aagccggagg tcatgctgtt tgacgagccg acatcagcac ttgatcctga 2121721 aatgatcggt gaggtgctag atgtcatgaa aacactcgcc aaagaaggca tgacaatggt 2121781 tgtcgtgaca cacgaaatgg ggtttgccaa agaagttgcc gaccggattg tcttcattga 2121841 cgaaggaaaa attttagaag aagcagtgcc ggctgaattt tacgcgaacc cgaaggaaga 2121901 acgggcccgc ttattcttaa gccgtatttt aaatcattaa aacagaaatg ggggagcttg 2121961 tatgaaaaag attttttctt tagcattgat ttctttattc gctgtcatct tgcttgccgc 2122021 ttgcggcagc aagggatcaa acggagaagc ctcaaaggag agcaaaaaag atacgctagc 2122081 cgccattaaa gacaatgaca aaattgtctt cggcgtaaaa acggacactc gactgttcgg 2122141 tcttaaaaat ccaagctcag gtgagattga gggttttgat attgatattg ctaaacaaat 2122201 cgctaaagac attttaggtg atgagaaaaa agctcaattt aaagaggtca cctcaaaaac 2122261 aaggattcct atgctgcaaa acggggatat cgacgccatt gtcgccacaa tgacgatcac 2122321 tgaagaacga aaaaaggaag ttgacttttc tgatgtctat ttcgaggccg ggcaatcgct 2122381 tctcgtgaaa aaaggcagca aaatcaagag tgtcgagaat cttggcaaag gctcaaaagt 2122441 tcttgcagta aaaggctcca cctcctctca aaacattcgt gaaaaggcgc ctgaagcatc 2122501 tgttttagaa tttgaaaact acgcagaagc ctttacagcc cttaaatcgg ggcaaggcga 2122561 tgccctcacc acagataatg caattttata tggaatggct gatgaaaata aaaattatca 2122621 attaacagga aagcctttta cagatgagcc ttacgggatc gccgtgaaaa aagggcaatc 2122681 tgctctcgcg aaagaaatca acgcttcact taaaaagatg aagtcggatg gcagatacga 2122741 tgaaatttat aaaaaatgga tcaaagaaga cccagctgaa taacaaccat cccgggatga 2122801 gcaggcgatg ctcatcccaa tttgataagg agtgaatagg cagatgaatg tgtcaattct 2122861 tttcgataac ttcagcatgt atatggacgg tttttaccat accttgctcg caagtgttat 2122921 cgcgctggcc ggcagttttg tcctcggcgt tgctgtagcg gttatgagaa taacagtctt 2122981 taagccgctg caatggctcg ggaccgcata tgtagaattc atccgcaaca tccctcttct 2123041 tttaattacc tttgttttct atttcggact tccaaacgca ggcctgaggc ttgacggttt 2123101 tcaagcggga acggttgctc tcaccattta tacctctgcg tttatcgctg aagccatcag 2123161 agcaggcatc cagtctgttt caaaagggca gatggaagcg gcacgctcgt caggctttac 2123221 ctacagccaa gccatgctcc atatcatttt gccgcaggca atcaaaatcg tcattccgcc 2123281 tttaggcaat caatttttaa acttagtcaa aaactcttcg attcttgggg ttgtggccgg 2123341 attggatctt atgtaccaag ccgatttagt ttcgtcgagc acactcgttg tatttgatgt 2123401 ttatattttt gtggcgcttt tttacttagt gctgacgatt ccgcttagca tcggtgttaa 2123461 ctatctggaa aaacggctgg aaaaaagcta ttgataagga gtgagttaca ttggatttca 2123521 tcggtgctta ttcacaggag catttagcgt ttttatggga tggctttctc gtcaccttgt 2123581 acgttgcttt catctccatc attctgagct ttttcttcgg tttaatcgca ggcaccctgc 2123641 gttatgcgaa agttcccgtt ctttctcaat tgattgcagt tctcgttgaa acgatcagaa 2123701 acctcccctt gctgttaatt attttcttta cgttttttgc ccttccggaa attgggatta 2123761 agcttgaaat tacagctgct gcaattacag cactaacgat ttttgaatcc gctatgctat 2123821 ctgaaattat ccgaagcgga ctgaaatcaa ttgacaaagg acaaattgaa gcggcgcgct 2123881 cctccgggct gagctataca cagaccctgt tctttatcgt tatgccgcaa gcgcttcgcc 2123941 gcatggttcc gcccatcgta agccagttta tttctttatt aaaagataca tcgctcgctg 2124001 ttgtgatcgc cctgcctgaa ctgattcaca acgcgcaaat tattaacggc caaagcgctg 2124061 acggcagtta ttttttcccg atctttttac ttgcggccct tatgtatttc gcagtcaact 2124121 acagcctttc actcgcagca agacgcctcg aggtccggca aacatagaaa aggatactct 2124181 ttggagagta tcctttttgc attaaaacat tttcgtaatt cttcttctca tccgcttcat 2124241 gcttcgatta ttcagcatgt cagattgagt cgccattcgg tacacgagag ctccggctcc 2124301 cattgccaaa agagaagtca tcgtccgatt catcctgcgc atctcctttc atgattaaaa 2124361 attgatgctg cgttcatcct cagaaaacaa atcatccaag ctgcttaacg ttccgtcttc 2124421 ttccacctga tgagttgcaa tcttcccttt cgccactgtc agttcaataa aacagcccca 2124481 gcaataatat tggttcacgc cgattttgcc gatatcctta cttttgcaat tcgggcatat 2124541 aagcatacct cacacctcta tccgttcaga acgatctcgt ctttccgcac ctcgacaagc 2124601 gaatccgctc tttggatctg gcgcttgctt cccgccaggt cagaaaagaa accgtccgag 2124661 agttcatatg ctacgattat gcccctgtcc aaacaaaagt atacatcttc cagcatcccc 2124721 aatatatccc cctcttgcga tttcacaagc ttcatcttca tctgctcgta tgtgaagcat 2124781 gatttcggaa gaggcaaaag ctgttctgaa ctgaccgaag ccaatatgcg gtcatcaaaa 2124841 atggaagaga tatcacacgc ccgtaatagc gcatgatgat gatgcaaaaa gcgtttttgt 2124901 gcaagaataa acccaagaca atctcctttc agagaaaaac aaatatcgga aattgtcccg 2124961 agataactag aagttcgttc tgagtatact gggaatcctt ctacttcatg gcatgttctc 2125021 aaagtgtgat caaccacctt ttgttgaaca ggcttaggtt ttgctttgcg ccttagactc 2125081 atacgatgaa atcaattcca ctgcaaatga aaaaaaactc ccgcttgcac gggagcattt 2125141 tattgctgtt cttctttcat aaaatcgaat ggtgtaatgc cttccatgcc aatgttggcg 2125201 tcgtgtacgc tgaacgggag ctctttttgc aaagcttcaa gctcggcatc catttcctca 2125261 acctgtacgg acagcctgtt tttcaaggag gtctgtctga cagttgcatc attatttttc 2125321 acgccccact ccagcgcctc ctcttccccg cataaaatga gaaatttctt cgctcttgta 2125381 atcgcggtat aaagaaggtt tcttctgagc attctataat agcctttcac aacaggcaaa 2125441 accacaatcg gaaattcact tccctgcgat ttatgaatag aacagcaata cgcatgggta 2125501 aattgattaa aatctttttt cgtaaatgtc atttcattgc cgtcaaaaga aacgacggcc 2125561 atgtcttctt tttctgtatt ttcctttgca taaaatatcg acgtgatttc gccaatatct 2125621 ccgttgaaca cattgttttc cggctgattg acaagctgca aaattttatc tccggttctg 2125681 tagacaacat ccccgaactt caattctctc cgtttttctt taggaggatt taaaatgtcc 2125741 tgcagcatca cattcaattc attaatgccg gcttttcctc tgtacatcgg agcgaggacc 2125801 tgaatgtcct ttgctgtata gccttttttc aatgcattgg cgacaacctt ctcaactact 2125861 tctttgattt gcgacccgcc gcagcgaata aaggaacggt cctttgtcgg ggcagtcaaa 2125921 ttgttcggca gcaatccatt tttcatctgg tgggcaagct cgacgattga tgacccttct 2125981 gcctggcgat agatgtctgt cagtctcaca gtcggaatca cctgggatgc cagcaggtct 2126041 ctgagcactt gtcccggacc gacggaaggc agctggtctt cgtctccgac aatgatgatt 2126101 tgtatatgat cagggatcgc cttgaacaaa tgattcgcca gccatatatc aagcatactg 2126161 gcttcatcga taattaacag cttcccttcg atcggctgat cctctgtatg agtaaagcct 2126221 tcagcgccgt tccagccaag cagcctgtgt atcgtaactg cagggagtcc cgttgattca 2126281 ctcatccgtt ttgctgctct ccctgtcgga gcggccaaaa caatcggaaa agcttcatcc 2126341 tttttataag ctgacgggtc tagtgacaca ccgtgaagct ctccgtagag ctcgacaatc 2126401 cctctgatta ccgtcgtttt tcctgttccc gggccgcctg ttaaaagaag catcggcgag 2126461 gaaagggctt tttgaatcgc ttccttctgg ctgggggcat actgaacgtc catccgttct 2126521 tccagttctc ccaacgcgag caaaaactct gattcgggaa actggttctc atattcggtt 2126581 tggctagcga tatgtttcac acgctttgca acgttttgtt ctgcgtaaaa cagcgaagga 2126641 aaataacagc ggccatcttc tatgacaatg tctttatttt ctccaagggc aataattgcg 2126701 ttagcggcat ccatttctgt aatgcgctgc ccttcccttg ctgactggtt taacagtgat 2126761 tgagtgtcga tgatcagctg ttccgtttct atgtacgtgt gcccctctga cagacaagtc 2126821 gtttcaagcg tgtacaaaat agcagctttt acccgctcag gatgattacc cgaaagaccc 2126881 attctgctgc ccagctcatc cgcttttcca aacccgatgc cttctacatc cttcacaagc 2126941 tgataaggat tttcctgaat cttttcaagc gtctcggatt cataggcttg atagattttc 2127001 atagacagct gcgggccaaa gccaaactga ttcaaggaaa tcatgatttg ctccagtccc 2127061 tgatgccgct gcaatgcgcc agccagcgtg tctgctttct tttttgagag tctgggaaca 2127121 tcataaagca ctgaagcatc agccaatatt ttattaatgg cgctgtcgcc cagctttttc 2127181 acaatttctt cagctgtttt tttgccgatc ccctcgaata aatcactcga taaatattga 2127241 atgatgcctt ccttagtcgt tggaatctcc tttttgaaat gctccgcctg aaattggagc 2127301 ccgaattttg gatgggttac gatctttccg taaaacgtgt aggtctcttc ttcttgaagc 2127361 gcagggaagt agcccgtcac ggatacggct ttatcttcaa tggcttcgga ggtctctgtg 2127421 actttcactt tcagaaccgt atataaattg gtgtcattat gatagatgac tgtgttgact 2127481 gtccctttta aatagggctc ttcctccagt ttaagctgat ccggatgctg ctgcacgagc 2127541 tgtccctcct cctgtgcctg ttatgatgga tcaatcagtt ttttagcatg aagcgcaagc 2127601 atatgatctg gctggatatc gattgccttg tccagcattt ccagcgcttt ttctcggttt 2127661 tctttataag cataagtgac accggcatta taaaatgcat ctgcatgccc cgggtcttgc 2127721 tctgtcacag ctgcgaattg gctgagcgct tcgtccagca tgccctcgtt ggctaagcac 2127781 atcccgaatt gaaaacgcgc ttccgtatcg ttttcattca gttcgactgc tctttgtaaa 2127841 tatggcagtg caagcttagg ctgttcgagc ttgacaagta ccgttccgag catgtaaaac 2127901 aggtcgccgt tttccatccc cgcacgtagc gctttttcaa acatgtcttt cgcttctttg 2127961 tacatttctt ttacaacata gacatttcct gctccataat aagcagtggc tgcgctactg 2128021 tctaattcaa gcgctttatc ataaaacgca agcgcacgtt ccagctcgtt tacggatgaa 2128081 agaaggttgg caaaattgat atacggaatc gcgtcttctt tattttcttc aatcgctttt 2128141 gtaaatgcct ctgccgcttt ctcgtaatcg ccttcctgca tcgcctctat accgagttga 2128201 ttataatcca ccgatcatct tcctttcatt aaaaaacccc aactcagtgt tgaggttttt 2128261 catcttttat acgtaccaca attttgttcc gtctttgtac acatcatcaa ttgtcccgcc 2128321 gccaaggcat tcttcgccgt catagaagac aacggcttgt cccggcgtta cagcgcggac 2128381 ttgttcatca aagatgactt ccgcttcacc ttcgccagtc atgcgcactg ttactttatg 2128441 atcctcttgg cggtaacgga atttagccgt gcaggaaatc tcttcgccct tcatgatatc 2128501 cgaacgtacc cagctgatat ttgttgctgt gattttgtcg gaatataaaa gcgggttatg 2128561 gaacccttga tctacgtaga ggatgttctt ttcaagatct ttgcctaccg caaaccacgg 2128621 ctcgccgctt ccgccgatgc caaggccgtg acgctgtccg atcgtatagt acatcaaccc 2128681 gtcgtggcgg ccttttactt cgccgtccat cgtcatcata tcgcccggct gtgcagggag 2128741 atattggctg agaaacgttt tgaagttgcg ttcgccgata aagcagatgc ctgtactgtc 2128801 ttttttcgtc gctgttgcaa gttctgcttc tttggcaatt tcacgcacac ggcttttttg 2128861 aagttcgccg atcgggaaca tgactttgct cagcgtatct tctgtcagct gattcaggaa 2128921 gtacgtttga tccttgtttt catcaatgcc gcgcagcatt ctgacttttc cgccgcttct 2128981 gtctactctt gcatagtggc cagtcgctaa atagtcggcg ccaagtgaca atgcatgctc 2129041 caaaaaggcc ttgaatttaa tttctttgtt gcacaataca tccgggtttg gtgttctgcc 2129101 tgctttatat tcatcaagga agtattgaaa taccttctca taatattgct tttcaaagtt 2129161 tacggcataa tacggaattc cgatttggtt gcagacgcgg atcacatctt cataatcctc 2129221 tgtcgccgtg caaaaaccgt tttcgtccgt atcatcccag tttttcataa agattccgat 2129281 tacatcatag ccctgttctt ttaacagcag ggccgccaca gatgagtcta ctccgccgga 2129341 catgccgacg acgactcttg tatcctccgg ccgtttttcc atttcattca ctccaattac 2129401 tacgccgcct tattatgtca gccgtttgac aacgtcggcc acatgtttgg cagcagtttt 2129461 cacttgctca gccgtattgc cgaggccgaa gctgattcga atagaggacg tcagccggtc 2129521 actctcttcg ccgaacatag cagtcagaac atgtgacggc aggactgaac cggccgtgca 2129581 cgctgaaccg ctggagacag cgacaccagc catatcaaga ttaaccagca gcgcttccac 2129641 tgacacaccg gggaaataaa gattcagaac atgcggcaga ctatgctctt tgtccccgtt 2129701 gacctcgaat gccacacctg catctctaag cgtgtcggca aagattgctt taaacgattg 2129761 atacttctcg tttttttcgt cacgttcttc acttgacagc ttgatcgctt ctttcagccc 2129821 gacaatgcct ggaacatttt ccgttccggc acggcgtttt ctttcttgct ctcctccgaa 2129881 taaaaggggt gaaagcttca catctttact agcatataaa aagcctgtcc cttttggccc 2129941 gttgagcttg tgcccggaaa cagacagaag gtcaatatgg ctgtttttca catcaattgg 2130001 cagcaacccg aatgcctgaa cagcatcggt atgaaaataa gctttgtgtt cctttaacag 2130061 ctcaccgatt tcttcgatcg gctgcactgt tccgacttca ttatttccat acatcactgt 2130121 cacaaggatt gtatcatcac gcagtgcttc tttcacctgt tttgcactga ctcttccatt 2130181 ttggtcaacg tccagatacg ttatgtcaaa tccgtctccc tcaagttttt cacatgtgtg 2130241 aagcacggcg tgatgctcaa tttttgttgt gatgatatgt ctgccaagat cttttcttgc 2130301 aagtgcggtt cccatgatcg ccaagttatc agcttccgtt cccccgcttg taaaaatgat 2130361 ctcctgctct gccgctccga tttctgctgc gatctgcgct cttgcttcat ccacccattt 2130421 tcgagattct ctgccaaatg aatgaatact ggagggatta ccgaaactgc cggagaagtg 2130481 cggtatcatt tgttccagca cgcgctcatc catcggagac gttgcggcat gatctaaata 2130541 aatccgttcc attatgttta cacctctgat ctaaatatag aacatataag cttcttgctc 2130601 tccgtctgta tagctggcaa gatcctctaa tgttgtactg tctaaaacct cttttacagc 2130661 atcccggatg cgaatccaga gctcacgctt ggcaggctcc tcatcttcca gcacttcaac 2130721 agggctgatc ggcccctcaa gcacacggat aatatctccc gcagtaatgg catccggctc 2130781 actgcctaat acatatccgc catatgcgcc tctgatgctt ttcactaaac cggcatttct 2130841 gagcggcgat accagctgct ccaaataatg ctcggacaaa ttattcgtct gtgcgatgct 2130901 ttttaatgaa gtcgggcctt caccgtgctt ttttgcaagc tcgatcataa tggtgagccc 2130961 gtatcttccc ttagttgata ttttcaacat gaacacctct gttatttcat gattttccac 2131021 atttataatg gtaatttcta tatgtttcgt ccgtttatta tcttatagac caactgttat 2131081 tataacatac cttcagcgaa ttttcattga ggcagaagga aaggggcctt tacccttttc 2131141 taatgtacgg ttttccgtta ccctgtaatt aagtaaggag agatgataga tgaagccatt 2131201 ggcatatcgg atgcgtccga caaaaataga ggatattatc ggccagcagc atctggtggc 2131261 tgaagataaa attattggca gaatggtcca ggcaaaacat ttgtcatcca tgattttgta 2131321 cgggccgccc ggaattggaa aaacatcaat cgcaacagca atcgccggtt caacaagtat 2131381 tgcttttcga aagctgaatg ctgtcattaa caataaaaaa gatatggaaa tcgtagctca 2131441 ggaagccaag atgtccggcc aagtgatttt gattctggat gaagtccaca ggctggataa 2131501 aggaaaacag gattttctat taccctattt agaaaacgga atgatcattt tgatcggagc 2131561 aacgacggct aacccgtatc atgccattaa tccggcgatc agaagccgga cccagatttt 2131621 tgagcttgaa ccgttaacac ctgaactgat taaacaggca ctggaacgtg cgctccatga 2131681 tgagcatcgg ggccttggca cctattctgt atccattgat gatcaggcga tggagcattt 2131741 tgcccacgga tgcggaggag atgtccgctc cgctttaaat gcgcttgagc ttgccgtgtt 2131801 gtcaacgaag gagtcagcag acggtgaaat tcacattaca ttagaaaccg cggaagaatg 2131861 cttgcagaaa aaaagctttt ctcacgataa agatggtgac gcgcattatg atgtactgtc 2131921 cgcttttcaa aaatcaatcc gcggctctga tgccaacgct gctcttcact atttggctag 2131981 attaattgaa gccggtgatc tggagagcat cgcaagacga ttgcttgtta tcgcctatga 2132041 ggatatcggt ttagcaagcc cgcaagccgg ccctagagtg ctgaacgcta ttcagaccgc 2132101 tgagcgagtc gggtttcctg aagcgcgaat cccgctggcc aacgcagtta ttgagctttg 2132161 cctctcaccg aaatcaaact ctgccattct ggcaatcgat gaggccctgg cagatatcag 2132221 agccggaaaa attggggatg tcccgaagca tttaaaagac gcgcattata aaggagctca 2132281 ggaattagga agaggaatcg actataaata cccgcacaat tacgacaacg gttgggtcga 2132341 acaacaatac ctccctgatc ctctgaaaaa taagcaatac tataagccga aacagactgg 2132401 aaagttcgaa tctgccttaa agcaggtgta cgataaatta atgaaaagaa aataaaacaa 2132461 aaaaacagcc ttgatcatca aggctgtttt tatgcattat ttatccttca cacgtttgat 2132521 ttcaatgtct ttcaaaagat ccatgacaac atgtccgccc ataatcaaac ctgcaactga 2132581 cggcacaaaa gcattagagg aaggcggcat ttttgcttta cgtattttcg cttcgtcatt 2132641 ccccacttct tttctgacat cttcccgaat aacaatcggg ctttcatcag agaaaatcac 2132701 ttgaacgcct tttttgatac cctccttgcg taatttcgta cgaacgacct tcgcaattgg 2132761 atcagtgtgc gtttttgaga tatcagcgat ttggaagcgt gtcggatccg ttttatttgc 2132821 agcacccatg ctggagatga gcggaatatc ccgttttaga cattctttca ttaaatgaat 2132881 tttataacaa atggtgtctg acgcatcaat gacatagtca agaccatagt caaaaaactg 2132941 ctcatacgtt tcctccgtat agaacatttt taacgcgatc acttcacact ccgggttaat 2133001 gtctgcgatc cgcgccttca ttaaatcaac tttcggctgt ccgacagttg aaagcagcgc 2133061 gtgaagctga cgatttacat ttgtaatgtc gacatcatct ttgtcgacaa gcagaatgcg 2133121 gccgacgcct gaccgcgcga gagcttccgc cgcgaacgac ccgactcccc cgactccaag 2133181 cacagcaact gtgctgtttt tcagcgtttc aaggccttct tttccgatag ctaattcatt 2133241 gcgtgaaaac tggtgtaaca agaacctcac tccacattcg tattctggtt tcatctataa 2133301 aatggctgat ccatgagcag ccgttttttc tgcgcacaaa aaataaagtc ccaatagtgc 2133361 cgttgcagct ttcctttgtt ttgaacccgc tctcagcagg tgggtgccct cttttaaatc 2133421 ttgtaagtcc tctttaccga atgaaaagag gcatgtacgc catttaaaaa tgcgggctcc 2133481 caaatcaaaa aaatgttcgg tcaaaactag gtgtacaact aacacatcag gactttattt 2133541 aacttgtcaa aatcatatca cagacgattt tgattttcaa gaatcgaact gcaaattcag 2133601 ttcttaactt ttttcttgat agaaagatga agctcgtcaa gctgggcgtc gcttacttcg 2133661 cctggcgctt ctgtcatcag gcagcttgca cttgccgttt tcgggaatgc aatcgtatct 2133721 ctcaggttcg tacgtccagc gagaagcata acgagacggt ctaagccgag tgcgattccg 2133781 ccgtgcggag gagcgccgta ttcaaatgct tccagcagga atccgaactg ttcagccgct 2133841 tcttctggtg agaagccgag aagcgcaaac attttttcct gaatatcctt ttcgaaaata 2133901 cggattgaac cgccgccaag ctcatagccg tttaagacga ggtcataagc ttgcgctttc 2133961 atgtcttcag gcgctgtttc aatcagctca aggtcttctc ggacaggcat tgtgaacgga 2134021 tggtgcgctg cgtaaaaacg gccttcttcc ggatcatgct ctaatagcgg ccagtcgatg 2134081 acccataaga aattgaacaa tttttcgtca atcagtccgc gttctttccc aagctttaag 2134141 cgcagggcgc cgagtgatgc ggccacaact tcgaattgat ccgctccgaa cagcagcaaa 2134201 tcaccttcag cagcatcaag tgcttcaatc agcttagact gcttttcttc atcaaagaat 2134261 ttagcgatcg ggcctttcac tccgtctgcc tcaaccttca cccaggcaag cccttttgcc 2134321 ccgtagtttg cagcaaaagc gccaagagcg tcgatgtctt ttctggagta atcgccggca 2134381 ccgcctttta cattgatggc tttgaccacg ccgccgtttg ctacagctga tgagaacact 2134441 ttaaattccg tatcctttac aatgtcagac acatccgtca aaagcatgtc aaaacgcgta 2134501 tccggtttat cagacccgta cttgttcatt gcttcgtcat acgtcattcg aggaagagga 2134561 agctgaagtt cctcaccttt tgtttcacgc ataacctttg ccatcatctc ctcagccaat 2134621 gacataatgt cttcctggct cataaaggac atttcaatat caatttgcgt aaactcaggc 2134681 tgacggtccg cacgcaagtc ttcatcgcgg aaacagcggg caatttgata atatcgttca 2134741 atgcctgata ccatcagaag ctgtttaaat agctgcggag actgcggcag cgcgtagaac 2134801 tcaccttcgt gcacacggct cggcaccaag tagtcacgtg cgccttcagg cgtgcttcct 2134861 gttaaaatcg gcgtttcaat atcaagaaac ccattttcat ctaaaaagct gcgaacagct 2134921 ttcgtcacgt tatggcgcag ctgcatcgtc tggaacatag ccggtctgcg caaatctaag 2134981 taacggtgtt ttaaacgaac gtcctctgac acttcttcag cttgatcaga aatcgcaaat 2135041 ggaggtgtct ttgcagcatt taatacgttc actccatcag catgtatttc gatcgcgcct 2135101 gttttcaaat tcggattaac tgttccctct tcacgcgcca ccacttttcc ttgaatatca 2135161 agcacgtatt catttctgat gccttccgca atagcaagcg cttcttttga cacatcaggg 2135221 ttaaaaacga cttgaacaat gcccgtacgg tcacgcaagt caataaaaat caatccgccg 2135281 aggtctcgtc ttttttggac ccagcctttc agcgttacag attcgccaat tgctttttca 2135341 gttatatcac cgcaataata tgttcttcca aacaatgcgt ttcactcctt atcccttttg 2135401 gtttgccttc atcacatgta taaattcatc aagtgccact tcaatctgtt cgcccgtctg 2135461 tgcatccttt acattgattt tgttttgggc aagctcatct tcacccaaaa tcgcaataaa 2135521 tctggccttt aagcgatcag ctgttttaaa ctggcctttc attttcttat tttcataatc 2135581 gatttcactg gaaatgcctg cttctctcag tttgtacacc aatgaaacag aataatcctt 2135641 tgctttttcg ccgagtgtga cgatatagca gtcgattccc ttatcaacag gcagctctct 2135701 tttttcagca tcaattgcgg caagcaagcg ttcgatgctc atcgcaaatc cgatgcccgg 2135761 tgcttcaggt ccgccgatct gttcgacaag cccgtcgtag cgtccgccgc cggcaagtgt 2135821 cgtaatcgcg ccaaagccct ccgcattgct cataatttca aatgcggtgt ggttgtaata 2135881 atccagccct ctcacaaggt tcggatcgat ttcatacgaa atgccaagat catttaagta 2135941 ttgtttcact ttttcaaaat aagcggctga ttcttcattt aaatatgtca aaatcgaagg 2136001 tgccgatttc atcagctcat gatcacggtc ttttttgcag tccaaaattc taagcgggtt 2136061 cgtgtgcagc cgggactggc agtctgaaca aaattcttcg atgcgaggct cgaagtgttt 2136121 cacgagcgct tctctgtagc ttttgcggct atcttgatcg ccgagactgt ttatgacaag 2136181 cttaacgttt tctaaacctg ctttttcata aatactcatc gcaagcgcca ttacttcagc 2136241 gtcgattgca gggtctttcg aaccaatcgc ttcaattcca aactgataaa actggcggta 2136301 acggcccgtc tgaggacgtt cataacggaa catcggcccg acataataaa gctttgtcgg 2136361 ctgtacagga tttgcgaaca gcttgttttc attaaaagcg cgaaccgcag cagctgttcc 2136421 ctccggacga agcgtcaggc ttctgccttt gcggtcctcg aaggtataca tttctttttg 2136481 tacgatatcc gttgattctc cgacgcctct ggcaaacagt tctgtatgct caaaaatcgg 2136541 tgtgcggatt tctttatatt gataagtgcg gcaagtgtct ctcataattt gttcaacaaa 2136601 ctgccagcga tctgattctc caggcagaat atcctgtgtt cctctcggaa tgttatatcc 2136661 cataggtaga cctccttatg tattccttat aaaatatcca atgatcgtta atgatgaaaa 2136721 tgaaaaaaac tcccgcccct actatacatg atagtaggga cgagagttat acccgtggtg 2136781 ccaccctagt tggaatacgt tcatattccc gctcgatcct ttaacgcagg ttcacgttca 2136841 ctgcctaatg gcgttattca cgcgttcagc aggaaacctc cggagtgttg tttcgagaaa 2136901 gacgcaatgg gatccgcttt cagcctgggg cgggttcctc tctaatcatg caatctgacc 2136961 tactcttctc cattattggt tcaaatcttt catcatttgc tatgtactca atttctatta 2137021 taataatggg attggggttc tctgtcaagc tttattccgg ttgtttttcc tcagcgctgc 2137081 ttctttggac ataagaccaa attcagatgc tgtttccgta agataaccag tcgtatcggg 2137141 atctgcgtga tcgctgtaat gcagattcgc ttcaccgtcg tgaaatgcac gtcccatttt 2137201 tggatgatat ttcatgattt gcacaccttt ttgattgtat ttacgcttag tataaacaaa 2137261 tcattttatt tttatttaaa aatcagaaag gactttacga tattaaacaa gaatgctttt 2137321 ttaatgatca tcagaaagga ggacacaatg aacaagaaat actttgtcct tattgtatgt 2137381 attattttca cctcagcgct attcccgacc ttttcatccg ttacagctgc tcaaggagaa 2137441 gcggtcatcg caacagatga aatgaacgtc agaagcggcc cagggcttag ctacggcatt 2137501 acagcggaag taaaaaaggg agaacgctat ccaattttaa aggaagatgg agactgggtg 2137561 cagatacagc ttggttctgg agaaaagggc tgggtagtct cctggcttat tacaaaggaa 2137621 gaccaggcca gcacaagctc ctcaggaagc agtgacactg tgacatcaac agaccccgat 2137681 ctgcggatga gaagcggccc gggcacttcc tacgaagtca tcggcaaatt cccgcaaggc 2137741 agccaagcat ctgtcattga taaagattcg ggctggatca agatatccta tcacagtgcc 2137801 accggatggg tatcatctga atatgtcaca tcaggaggca gcagttcagc gtctgatgag 2137861 agtgaccaaa ccgaggattc cggtgcgtca acgacgggca cagtcggtgt ttcttcgcta 2137921 aatgtaagag cctccgcctc acatgacgcg gcaattataa caaaacttga tcgcggaacg 2137981 aaactgacgg ttctcaacga gaaaaatggc tgggctcaca ttgaggtgaa cgggctaaaa 2138041 ggctgggttg caagccatta ccttttgact agttctgttc cagctgatga ttcagcaaat 2138101 gccggcagtt catcctccgc taaaaaagcc tatatcatgt acggaggaac gaatctaaga 2138161 agtgatgcgt caacatcagc ttcgatcgtt gagcgcgctg ccaaaggaga ttcatacacc 2138221 attaccggtt caaagggaag ctggtatgaa ataaagcttg ataacgggca gactgcttat 2138281 gtagccaatt gggtggtcca aacgtctaaa agcgcagaag aagcaggtga accgccagtc 2138341 tctgattccc cgtctggaaa cggctctcta aacaataaaa cgattattgt tgacccggga 2138401 catggaggaa aagacagcgg aacgatcggg tattcgggga aattcgagaa aaacctgacg 2138461 atcaaaacgg caaaactgct cgccagcaaa cttagatcgg ctggagcgga tgtatatgtg 2138521 acacgccagg atgatacctt tgtcagcctg cagtcacggg tctctacctc tcactaccgt 2138581 aacgctgacg cctttatcag cattcattat gacagctatg cggatacctc tacaagaggc 2138641 agtacagcat attactacag tcctgccaaa gatcaggaac tcgcatcaga tgtccactca 2138701 gaagtggtga agcgttcttc cattccagac cgcggcgtat tattcggaga ttattatgtg 2138761 ctccgggaaa acagacagcc cgctatgctg tacgagctgg gatatgtaag ccatccgcag 2138821 gaagaagcca ttgtacatag caattcatac caagaaaaag taacagatgg gatcgaaagc 2138881 ggattagaga aatacttcca ataaaaaaag ctgccttttg gcagcttttt ttattttgaa 2138941 tccataatga gcgtgaccgg tccggagttt gtaagctgaa catccatcat tgctccaaac 2139001 gttccggtct ccactttgat tcctttttca cgaagcaggt cattccattt ttcataaaga 2139061 cctaaagctt tatcaggttt ggccgcgttc atgtagttcg gccggcgccc ttttttcgta 2139121 tctccataaa gcgtaaactg tgagacggat aaaatctctc ctcctatatc tacaagagac 2139181 agattcattt tcccttcact gtcatcgaaa atacggagat tgacaacttt atcggctaaa 2139241 taagctgcat catcttctgt atcatcgtga gtgatgccga ccagcaccat aaggccttgt 2139301 ccaatttggc cgacgacctc ttcgtccact gtaacgcttg cttctgttac tcgctgaaca 2139361 actaatctct tttctaaccc ctttagttca tgacgcggcg cacagaatag atatctctaa 2139421 tctgtttaat acgctcgacg actttatgca agtgattgat attctggata aaaatcgcca 2139481 tatggatggt tgccacttta ttgcgatccg atttgccaga gacagatgaa atattggttt 2139541 tcgtttcatt cactgcctgg agtacctcgt tcagcaatcc gcggcggtca tacccaagaa 2139601 tctctatctc aacattgtat tccttgcgct tttgaacttg tgactcatgt tcccactcta 2139661 ccgggatcag ccgctcttgg gcttcattcg ttttgacatt cggacagtct tcgcgatgga 2139721 ccgaaacccc tctgcctttt gtgataaagc cgacaatatc atcacctggc acaggattgc 2139781 agcattttga taaacggaca aggaggttgt caatgccctt gacacgaacg ccagcttccc 2139841 gttttcttcc ttgcgggtat ggcttaggtt ccccagtgac ttcctgaacg atcttttcct 2139901 gttcttcctg gtcgcgctgc tttctctctt tttctgttag gcggttcgcc acctgcagag 2139961 ctgtgatgcc gttgtaaccg accgccgcgt acatatcctc ttcatttgag aaattaaatt 2140021 tgtcagcaac cttttgaata ttctccggcg ttaaaacatc cttcaattca aaatccaagt 2140081 ttttaatttc tttttcgacc agctcacggc ctttttcgac attttcttca cgccgctgtt 2140141 tcttaaagaa ttgacggatt ttatgcttcg cttgggatgt ttgggcaagc ttcacccaat 2140201 cctggctcgg accgtaggaa tgcttagagg tgagaatttc aacgatatca cctgtccgaa 2140261 gcttatggtc aagcgtaacc atttttccgt ttactttggc accgattgtt ttattgccga 2140321 tttcagagtg aatccggtaa gaaaagtcaa tcggaacaga accggacgga agctcgatta 2140381 catctccttt tggcgtaaag acatacacca tgtcagagaa caaatcaatt ttgagcgatt 2140441 ccataaattc ttctgcatct gtcgattcat tttgaaattc taaaatttca cggaaccaag 2140501 aaagcttttt ctcaaaggtt gcaccttcat tggctgcttt cccttcttta taagcccagt 2140561 gagccgcaac cccgtattcc gctatttcat gcatttcaaa ggtgcggatc tgcacttcaa 2140621 gcggatcgcc tttaggccca ataaccgttg tatgaagcga ttgatacata ttcggcttcg 2140681 gcattgcgat ataatctttg aatctgcctg gcatcggttt ccagcatgtg tgaatgatgc 2140741 caagcaccgc gtagcagtcc tttatgctat tcacaagaat acggacagcc aacaaatcgt 2140801 aaatttcatt gaattgctta ttttgcagca ccatttttcg ataaatgctg taaatatgtt 2140861 tcgggcgtcc cgagaagtca gccttgatat ttacttcttc gacacgtttc ttcacttcat 2140921 tgacaacctc atcgacataa agctctcgtt ctgcacgttt cttcttcatg aggttgacaa 2140981 ttctgtaata ttgctgaggg ttcaaataac ggagcgccgt atcttccaat tcccacttaa 2141041 tttttgaaat cccgagacga tgcgccaaag gagcaaaaat ttccagcgtt tcattggaga 2141101 ttctccgctg tttttcctga ggcagatgtt tcagtgtccg catattgtga agacgatccg 2141161 ccagcttgat caatatgacc ctgatatctt gagccatagc gacaaacatt ttgcgatgat 2141221 tttccgcctg ctgttcctct tgagatttat atttaatttt gccgagtttc gttacgccgt 2141281 ctacaagcat tgccacttct tcggaaaatg cttctttcag gtcatcgagc gtcacatctg 2141341 tatcttccac gacatcgtgc aaaaatccgc ccgcgattgt ggaagggtcc atttcaagat 2141401 caacgagtat ccccgcaacc tgaatcggat gaataatata tggctcgccc gatttgcggt 2141461 attgctcgcg atgagcatct tcagcgtaca gatatgcttt ttcgacaaat gcgatatgct 2141521 catcagatag atagctgcgt gctttatcta taacttgctc ggcagtcaat acttgttcgt 2141581 tcgccatgga atcacctttt ttaaaatgta aactgtattg tagtttatta tcaagaaaaa 2141641 aacgaaagat gtaaagagca gaagttcaaa tagccaaata ttatataaaa taaatgcaaa 2141701 acaataggaa aaaagcaccc tgacatggag tgctttttcg ttatgcggtt atccttagta 2141761 tttcatcaat gttaagatgt cgtaatcttc gagcttattt ctgccgtcaa ggtaagaaag 2141821 ctcgattaag aaagcgatac cagcaacaac gccgccaagt tcttcaacaa gtttgattgt 2141881 cgcttcaatt gtgccgcctg tcgcaagcag gtcatctgta ataagcacac gctgaccagg 2141941 cttaatcgca tctttgtgga tcgttaatac gtcttttccg tattccaagc cataatccac 2142001 tttgattact tcacgaggca acttgccttc tttgcggacc ggcgcaaaac ctacgccaag 2142061 cgcgtaagca acgggacagc cgataataaa gccgcgcgct tcagggccaa cgaccaaatc 2142121 aatttgcttt tctttcgcat attcaacaat ttgatctgtg gcatagcggt atacatcgcc 2142181 tttatccatc agtgtcgtaa tatctttaaa ttgcacgccc tctttcgggt aatccggtac 2142241 aattgttacg tattgtttta aatccatctg ttttatgtcc tcctcgtact ttcataagcc 2142301 tctgaatctt gtttcatcag cttattcagc cattccttca gctcttcagc agaagaataa 2142361 ttcagctttt gatccagttc catcagctgc tgtttcgcct gatatgtttg tgagtctgtt 2142421 aagtcgcgtt tctttgctcc gctcacaaca gacagcacac cattctctat tttaacaaaa 2142481 ccgagatcaa aaaacacctt tgtcatgaaa ttgattgttt caacggacca gcctttatgt 2142541 tttgcaagct ctgaaccgtg ttttttcacg tcaaaagcgc ctcttttcag caagaacgca 2142601 taataccatt taaagtggtc tcttgcggga aaagttgata aaaagtggtc ctcatgattg 2142661 agaaaaataa aatatatccg ctcgggcgcc tttccttcca gcaaacgtgc gagcatgtcc 2142721 agcgaaggcg gcggatccag taatacaata tatgcaccat cgaggtcaaa cgcctttgct 2142781 tgatctttag aactgatgac gtgcacttct cggcgaaggt cttcagtttg aagtaatgtt 2142841 gttgagtctt ctttgaaaga gacaatggcc cgtttagcag atggaagggc ggaaactgtg 2142901 tcttcccacg tccgttttcc ccttaaatca aacagctgcc attcagaaac agcggcatcc 2142961 tttatcataa gctgcggctt ttttcgattg ttccattcgt tgattgacat ctcaccgaca 2143021 atggaaattc ttgaacccgg tacgatgcct tcttgaagct cgcctttatt aaaaccgacg 2143081 caatcaagct gggacgactc gtttctgatc gtcattttga catgagtttt atttgcccct 2143141 atcttgcgga catcttccag tactgcattt tctacgagaa cgtgcggttt cgggttcagc 2143201 atgccaaaag gagacagcat gttcatttct gcgatgcttt caactgtaat gtcttcgacg 2143261 ccgcagacaa ggtcgacttc ctgtacggga ataaaatcct cttccgtaag cgtattgtcc 2143321 gctatttcat tcagcctgct tcgcaaatcc ggcacatctt cggctttcag cgtcatcccc 2143381 gcagccattg gatggccgcc gaaatgagga agaatatctc tgcattcaga aaggctctca 2143441 aataaattaa atcctctgat gcttcgggcc gaacctttag cgattccctt ttcttcatca 2143501 ataccaagaa caatggccgg tcggtagaaa cggtccacaa gctttgaagc cacaatcccg 2143561 acgactcccg ggttccatcc ggctttggcc acgacaattg cagtttgatc gagcccttgc 2143621 tgttcaacca tttcaatcgc ttcatccgtc attttgctga ccattttttg gcgctctttg 2143681 ttcagctggt caatttctgc ggcaagctct tccgcttcaa acgaatcctc tgacataagc 2143741 aaatgaacag cgggatccgc ctgttcgatt cttccgacgg cattcagcct tggtgcgagc 2143801 tgaaatccga ctgtttcttc gttcgcttct ccgatgtctc cgcctgacag cttaatcagc 2143861 tcttttaagc cgagccgatt tgtccgtcga agcctttcaa gtcctagtgt tgctattaat 2143921 ctgttttcgt catgcagcgg gactagatcg gcaatggtgc cgatagccgc caggtcaagc 2143981 agttcatcag gaagttcacc caataaagcg tgggcaagct taaacgcgac tccaaccccg 2144041 gcaagctctt taaacgggta agtgcagcca ggctgcttcg ggtggacgat cgcacggaca 2144101 tccggaagct ccggtcccgg ttcatgatga tcggtaatga tgacatccag tccgagttcc 2144161 tttgccacct tcgcttcatg cacagcggca attcctgtat caaccgtaat gatcaaagag 2144221 aagccccgtt ctttaatcga acgaaacgcc tgttcattag gtccatatcc ttctttaaaa 2144281 cggtcaggta tataaaaatc aacttgagcc gacagttttt gcagcgtgtg aagcatcact 2144341 gacgtacttg taaccccatc ggcgtcataa tcgccatata tcataatctt ttcttgttgt 2144401 gaaatcgcct gttttattcg atctgccgct tctttcatgc ctttcatttc aaaaggatca 2144461 taaaaatcgg catcctttgt atgtaaaaac agcctagcgc tttctgccgt atcaaagcct 2144521 ctttttacaa gcagggacgc aacaagaggt gttatatgca attgttctgt gagtgatttg 2144581 accttatcct gatctggtcg ctggatttcc catcgcattt ttgacgctaa cataaattca 2144641 cccctcaacc accctattat actagagcag gctgaggggt ttcaaataat attcgaaaac 2144701 tagtcttttt tctcaatcat ggctgatgca tcctgtgtgt cagtctgatc agcaagatga 2144761 gtatcctctt gtttatgtat tgctgttcta ttttctttcc gcaaggtttt tatttcccgc 2144821 ttcaatttca ttacctgaaa aatgccgaca gaaaatacga tcagtgctcc cattaaaact 2144881 gagcccaaaa taacaagaat gagcggccat tctgatcttc caaacaggta atcaacttct 2144941 acggatcgaa cattaatgac tgcgaaaata gcgacaatta aggtgaaaat aagtgcgaaa 2145001 ataatggtcc attgtttatt cattctcttt tcccccaaac ttcttattga ggtaactttc 2145061 ccaatcaaga ctggttttaa acatggctta acactaggtt aagctccctt tgctgttaat 2145121 ttttcccgga tcagcctctt cagtccggtt ccctcaccgg aaatcacaag tgtatcgcct 2145181 tcgtcaatga ctgtttcaga gctcggattc agttgtttat cctgattctt tttaacaatt 2145241 gcaatgaccg tcacatgata ttcctgaccc acattcaaat caccaatcgt ctgatgaatg 2145301 gcaggcgctc ccgcctctgc tttacaccac tctataatca aatcatcaag ggctgactcg 2145361 acctgttcta atgctttcgg tttatatgcc attccgccaa gaattgcaga catttgcctt 2145421 gcttcagcgt catcaaactg cacggaggca acacattcct catggtcgtt ttcgtcaaaa 2145481 tagtaaagct ctctccgtcc gtcatgatga atgataattg aaattttatc acggtttcta 2145541 gtaatcattt caactttttg tcctatgccc ggcagctctg attcgcgaac cctcatatat 2145601 aaaccctcct acatatctga aaaccagcca taaacacttt taacaccata tatatgttta 2145661 aatgtaagcg tatgtcatta tagcaaatgt ctattttaag ttcaatgaaa cttcaaaaaa 2145721 caggctgccc tgcagaggac agcctgatat tttttattgc gccgaatctt ttttcagttc 2145781 tcttcctttc catgcaagcc aaatttgtgc ggcaatgtat agagaagaat aaacgcctgt 2145841 taacagcccg accaataaag caattgagaa gttagtaata gaagatgctc caaagatcag 2145901 caatgtcaca acaacaatca caacggttaa tacagtgtta attgaacgtg taaaggtttg 2145961 ctgcaggctc aggtttacaa tatggttcag atcggcaaag gttttcggct tacgcttttt 2146021 catatgctcg cggaccctgt caaatgtaac gattgtatcg ttaatggaat acccgattat 2146081 cgtcaagatg gccgcgatga atgtaacatc tacctcaagc cttgtaatac tgaagaacgt 2146141 gacgataaag aatgcgtcat atagcaatga ggcgatggca gcaatcgcca ttttgtattc 2146201 gaatcggatt gaaacgtaaa taatgatgcc aatagaagct atagcaactg cgtacagcgc 2146261 atttctcgcc agctccttac cgactgtcgg tgaaactgtg ctgacatttg gatcagatcc 2146321 gtatttgtct ttaaaatacg tttttacttt tgcaatggtt tctttatctg gcaccccgac 2146381 aaaacgggca acaccgatat tgctcttttc gcctgacaga actacagtat cagggtccat 2146441 acccagagat tcaaaatcct tctcaacttg ctctgtcgtc agcttatggt cgctttgcac 2146501 ttcaatccgt gcaccgcttg caaagtcaat gccaagattc agcctgaaca caagcaggat 2146561 aataatcccg gcaaccgtga ccgcactgga gaaaataaag aagtatttgc gtttgctcgt 2146621 gaaatcccat ttttggaatg gcgtatgcgg ctctgtattt tcatccgtat cctgaatatc 2146681 catgatatgt ttcttattga caccaaacca gccttttttc cgatcaagcc atctgctttc 2146741 cacaaggaga gcgaggagaa atctcgataa gaaaacggca gtgataaagc ttgtcaaaat 2146801 cgataggatc agcattgtcg caaacccttt aacagagctt gtcccaaaga taaagagcac 2146861 aaccgctgca ataatggttg taatattcgc gtcaaaaatc gtcgcaaatg accgtctgtt 2146921 tcctgaacgg aaggcagagc ggactgactt tcctagcttg agctcttctt taatccgctc 2146981 ataggtaata atgttggcgt caacagccat cccgacacct aaaatgagag cggcaattcc 2147041 cggaagcgtg agtacggcat tcatccagtc aaagatctgg agtgtaatgt agatataaac 2147101 agacagcgta atcaccgcga ttaatcccgg cagacggtaa tagaaaagca taaataagaa 2147161 aataattgcg ataccgacaa taccggcaaa caccgtatca tggagagcct gctggccgaa 2147221 ttgcgcgcct actgatgtcg aatacttttc agtcagtttc acaggaagtg cgcctgcgtt 2147281 taaaatgctg gctaaatctt tcgcttcttg agctgtgaaa tgaccttcaa tttttacatc 2147341 agttgtattt agttcctgac ttacatttgg agcggataca aatttaggat gctctttttg 2147401 aacttctttc ttaaaggaat cacctttatc ataatccaac caaatgacaa gctggttgtt 2147461 tggcgccatt ttcatgacct tcttggtcac ttcaccaaat ttatcagcgt ctttcagctt 2147521 aatcgtgaca attggctcat ttgttgtgct atcataagtt tgtttagcgc cgttttcgac 2147581 tagatcagca ccgtttaaca gttccttatc atttgcatct ctgaaagaaa gctgcgcttc 2147641 agtcgccaaa atttcacgcg ctctgttttg gtttgtcacg ccagcgagct gaacgcgaat 2147701 ccggttattc ccttcaattt ggatgttcgg ttcgctgaca ccgagaacat tggcccggcg 2147761 gttcagtgcc tctactgtgc tgaccagaac gtcttttgtg attttgtcac ctttttttac 2147821 aggctgtaca tcatacagca cctcaaatcc gccttgcaaa tccaatccta acgtaatatt 2147881 gttagcggca ggcttcgtaa agtagcccaa gcccgtgccg atcaatagaa cgaaaaggaa 2147941 aaacgcaatc aagcgtcctt ttttcattat gtatatcctc ccttaaacct gtgcgaatca 2148001 acctgctatc tcagcagttc ttccaatgct tcctggccct cttcactgcc cagccaatta 2148061 gacgttttaa atgactcaac ggttgcatag ttcataaatt cgccaatttt cactgataaa 2148121 atatcactcg ccagttcata aatgctcagt tccgttttct ttttccactt cttatctgtt 2148181 aagtatgacc acaaactttc gagttcaaca tcatcatacc cgagaatctt aaactcttcc 2148241 agtttgctgt aaagaaacgg cctgacgtgg tctttatata gatcggctgg atgcttctcc 2148301 acgaattcca cgctcctttt ttattgtttt tcaagaagac ttgtcatgct tggacgacat 2148361 atacgcatat ctttattgta tatgattcca ggtagtttga gaaggcaggg ggtaaaaatg 2148421 gcgaaacaga cgtttttaaa gggcactctt atccttatcg cagcaggaat ggttacaaga 2148481 atgctcgggt ttgtcaaccg ggtggttatc gcccgtttta tcggtgaaga aggagtcggg 2148541 ctttacatga tggcagcgcc tactttcttc ttggccacta cattaactca attcggtctg 2148601 ccggtcgcga tcagcaagct agtcgctgaa gccagtgcgc gcggagatca tcaaaaaacg 2148661 aaaaatattt tagtcatgtc tctgaccatt acgggagtgc tcagcctcat ctttacaccg 2148721 ctgtttctgt ttttcgcccc tgttatggct gaaacgatgc tgacagataa gcgaacactg 2148781 tatccgctct tggccattac gcctgttgtg ccgattattg ctatatcgag tgtgctgagg 2148841 ggatactttc aaggaaaaca gaatatgaac ccgcttgcta tgtcacaagt ccttgaacag 2148901 gttgtccgca tttcactcgt ggctgtctgc acaacgattt ttctccctta cggaattgaa 2148961 tatgctgcag cgggggcaat gctatcctca gtggcagggg agctggcatc acttctttat 2149021 ttattcgttt gctttaagta taaaaagaca attaaaatca gaaagcattt tttacagtca 2149081 attaaaaacg gaaaacaaac ctttacccaa ttaatgagcg tgtcccttcc aacaaccggg 2149141 agccgcttta tcggaaacct ctcttggttt ttcgagccaa tcgtcgtcgc tcaaagcctt 2149201 gccatcgccg gtgtggcaac agttgccgca acaaagcaat acggggaact aaccggcttt 2149261 gccatgacgc tgctgactct gcccagcttt attacatatt ctttgtcgac cgcgcttgtt 2149321 cctgcgatca gtgaaggaat ggagcagaaa aaattgcagg tggtggaata ccgcttagaa 2149381 caggcgatgc gtctctgtct gctcagcgga ggcatttcag ttgttatttt atttgtattt 2149441 gcggatgagc tgatgagagt gatgtacggt tcctcaggcg cagctgtatt tataaaagtg 2149501 atggccccgt tttttctgct ttattatttc caaggcccgc ttcaagctgt gctgcaggcg 2149561 cttaatttgg caggagctgc gatgatgaac agcttaatcg gagcgcttgt caaaacaggc 2149621 cttatttttg tccttgccac aaggccttct cttggcatta tgggcgcggc attagccatt 2149681 gtgacaggca tggtgctcgt cacgctattg cacgcagcaa ccgtaagcaa agtgctgccg 2149741 atcagcatca aaatcaagga gtacgcgctc agcttcgctg ttattgtaat ttgcggattc 2149801 atcagctccg ccatcaaaca atatataagc tttggagcat ctgaggctgt caatctagcc 2149861 ggatggattg cggcgagcgc cgccatttat atgatcctcc tgctcgtttt ccgtttaatt 2149921 aaaaaagatg agcttcgccg cattcccatt atcggacggt tgatcatccg ataatggtca 2149981 cgtgcggtgc ccatcttttt catcaatata tatttctccg tctgtaaacg agcaaaatga 2150041 aatatctgaa gggtttgtgt atccgtgttt ttgcaaactt tcaagcagcc attttctatc 2150101 tttactgatt ctggacaggt tttctgtttg aatgaagccg tctataatga gcggcatttc 2150161 gagctgccga tgctctccgc tgttttcttt cttaacaata gtcagtttgc ccgacggctc 2150221 taaaatagca aatgatacgt cagctactct gtcgatgcta ttttctctga gctgaaccat 2150281 taaatcatca aaattataac gctgtgattt catggcttct tcgtcaattt ttccatattt 2150341 gataattatg gtcggcttac cgtcaagaag ctggcggact tttcggtttt ttaaagaaaa 2150401 gtatgccaaa gtcacttgaa tgatcattaa tacaagcatt ggcaaaatgg tatgaaatag 2150461 atgatcgtct acgttttcta tggctaaaac ggcaatttca gccatcatga taaagacaac 2150521 gagatctaaa atactaagct ctccgatctc ccgtttgccc atgaaacgaa aaatgaccaa 2150581 tatcacaaaa tacaatacga ctgtgcgaaa cgcaatagtg agaagctctt ccattatgca 2150641 cctccaactc attataggtt gcaacaaaat gatcaattta tgtaagaaaa accgattgca 2150701 tttcacaaag cttttacgtc taattcatgg gataagggaa tacattttta caaagacgag 2150761 ccatcagcat gtctgacggt tttgaacaaa aagaacagaa gccttttaat acaggcagag 2150821 aggagacaat catggaggaa acgaaacaag ttggaaaagg cattctttac ggcttaatcg 2150881 ccatattttc agccatgctc ctgacaagtt tagcggtttc acttttattg accgcaacct 2150941 cgctggaaga atcatcattt aactggctga tcaccgctat ctcatttctc tctttattta 2151001 tcggcgggtt catttcaggc gggaaaggca aggaaagagg ctggatgatt ggcgcattga 2151061 ccgccttaag tttttctctg attatcttat tgtttcagta tttaggattc ggaaagacat 2151121 ttacagcaga acagctgatc ttccatctgg gatttttagg ggtgtgcatg ctgggcggga 2151181 ttttcggcgt gaacatgagg ggaaacaggt cttccacata aaaaagagcg ggctcacttg 2151241 cccgctcttt tttgtttgct atgtatagct cctgctgtta ttcagcagca gaaacttctc 2151301 tgatcgcgcg gcggtcgaac gtaagacgtg tgttatcacc agtcttaatt acgactttgc 2151361 tttcgtcgat agagtcaaca gtaccgtgca atcccccgat tgtcactact gaatcgcctt 2151421 ttttcagttc ctcttgcatt tggcgtacag ccttttgctg cttttgctga ggacgaatca 2151481 gcaagaagta aaggaccgca aacattaaaa taataggaac caatgtacct aaagtgccag 2151541 tcatcatttt cacccctttc tgtaagcctg ttatgtttat ttagaagctt ttcgcatttg 2151601 gcttgttata gccgtaacgc tcaaagaact cttctctgaa atcacccaga cgatcctcgc 2151661 gaatagcctg tcttacctgc tccattaagt gtaacagaaa atgaaggtta tggtaagttg 2151721 ttaatcgaag gccgaatgtt tcattgcagc gaatcaagtg cctaatgtac gcgcgagtgt 2151781 agtttttaca tgtatagcaa tcacactctt catcaatcgg acggaagtct ctttcaaatt 2151841 tcgcattttt catattgagt cgtccttcag cagtaaacac tgtgccgttt cttgcaatcc 2151901 gtgtaggcag cacacagtca aacatatcga ccccgcggat cgctccgtcg atcagtgcgt 2151961 ccggagaacc tactcccatc agatatctcg gtttatcctt cggcaagagc ggtgttgtga 2152021 attcgagtac acggttcatg acatccttcg gttcacctac agacaatccg cctatagcat 2152081 atcccggaaa atcaagcgaa atcaagtcct tcgcactttg tgtccgcaga tcttcatatt 2152141 ctccgccttg tacaatacca aacagccctt gttcatcctg acgattgtgg gcattcaggc 2152201 agcgttccgc ccagcggctt gtccgttcaa ctgacctctt catgtagtcg tactccgccg 2152261 ggtatggcgg gcattcgtca aacgccatca taatatcaga gccgagtgcg ttttggatct 2152321 ccatcgcttt ttccggagat aaaaacagct tgtctccatt tagatgattg cggaaatgga 2152381 caccctcttc ctctatatta cgaaacttgc ttaaagaaaa gacctgaaaa ccgcctgaat 2152441 ctgttaaaat tgcgcggtcc cagttcataa atttatggag cccgcccgct tctttgacaa 2152501 tgtcttggcc cggacgaagc catagatgat aagtgttgct caaaatgatg cctgcatcca 2152561 ttgctttcag ctcttcaggc gacattgttt tgactgtcgc cagtgtgccg accggcataa 2152621 aaaccggcgt ttcgaaggag ccgtgaggcg tatgcacttt gcccagccgc gctcctgttt 2152681 gtttgcattc ttttataaat tcatagcgta ttggttgttc agccactttt gatgaggcct 2152741 cctgttctca aattatataa tcagcatcgc gtctccgaag ctgaagaaac ggtattcctc 2152801 ttccactgca tggttatagg cacgcagaat gttttctctt ccagcaagcg cgctgaccag 2152861 cataatcaat gacgatttcg gcaaatggaa gtttgtaatc attccgtcaa tggctttaaa 2152921 ttcatagccc ggataaataa aaatagatgt ccagccgctt gatgctttaa attgcccgtc 2152981 atgttctccg gcaatcgtct caagcgtgcg tgtcgaggtc gtgccgacag aaatgatccg 2153041 accgccattt tctcttactt tgtttaaggc tgcagccgtt tcttctgaca tttgataaaa 2153101 ctctgcatgc atattatgct cttccacttc atcggcactc acagggcgaa acgttccaag 2153161 gcctacgtgc agtgtgatga actcaatttg cacgcctttg tctttcagct gctgtaagat 2153221 ttcttccgtg aagtgaaggc cagctgtagg cgcagcagca gagccaattt cttttgaata 2153281 cactgtctgg tagcgctctt tgtcatcaag ctgttctttg atatatggag ggagcggcat 2153341 ctctccaagg gattcaagca cctcgtagaa aataccgtca tattgaaatt ccatctttct 2153401 gccgccgtgc tcaagctctt ccgtgcagat tgccttcaat cttccgtctc caaatgtgac 2153461 aacagttcct tttttcaccc gtttcgccgg tttggcaagt gtttcccatt tatcaccggt 2153521 ttcctgtttc aacaaaagaa gttccacttt cgcgccggta tcctcttttg tgccgaataa 2153581 ccgcgcaggc agtacccggg tattgttcag gactagacaa tcgccttcgt taaagaagct 2153641 gataatgtgt ttaaacgagc tgtcagtaag ctctcctgta tgtttatcga gcaccatcag 2153701 ccttgaagca tcacgctgct ccaacggtac ttgtgcaatt aaacgttctg gtagttcaaa 2153761 atcaaataaa tcgactttca tgatgatttc acctttattc tagtcttttg ttatttcatt 2153821 ctgccaaaaa gattaagcaa aattgataat accacactta taataataca agtgacaacc 2153881 gggaagaaaa acgtaacatt tccttttttt acaaaaatat ctcccggcat cttgccgaca 2153941 aaatgcaaaa ctgctccgat aataagcaaa acagcaccaa gaatcataat gatcttagga 2154001 aattcagtca tatcggggag cctccatttg gaaatgatga taaacggccg gtgtcacgat 2154061 ccttccacgc ggcgttcttt gtataaatcc aatttgcagc agatatggtt catatacgtc 2154121 ttcaatcgta tgcgattcct cgccgatggt agctgaaatc gtatcaaggc ctactgggcc 2154181 gccgttgaat ttttcgatca tgcccatcag cagcttatga tcaatatgat ccaaaccgag 2154241 gcggtcaacc tgaagccgct ccagcgcatt ctgagaaatg tcttccgtaa tcctgctgtc 2154301 acccagcact tgggcgaaat cgcgcaccct tctcagcagg cggttcgcca cgcggggcgt 2154361 ccctctcgat cttcttgcaa tttcaagagc cgacggttta tcaatctcaa cctcgaatac 2154421 atcagcggtt cttgtgacaa tatccgccag ttcttcttgt gtatagtact caaggcgaga 2154481 cattacgccg aatctgtctc ttaaaggagc cgtcaaaagc cccaccctcg tcgtggctcc 2154541 caccagcgta aaaggcggaa ggtcgaggcg aaccgagcgg gcagatgggc ctttgccaat 2154601 cacaatgtcc aggcaaaagt cttccattgc aggataaagc acctcttcga tcgatctgtg 2154661 cagcctatgt atttcatcaa taaataatac atctcccggt tccagcgccg ttaatatagc 2154721 agccaaatca ccaggccttt caatcgcagg ccctgatgtc gtccgcaatt ccactcccat 2154781 ttcattagca acaatcgaag caagcgttgt ttttccgagt ccgggcggcc cgtacagaag 2154841 aacatgatcc agcgtctcct gtctcatttt cgccgcatct ataaacacgc gcaaattttc 2154901 ttttacctta tgctgcccga tatactgtgc cagattttgc ggcctcaggc tttgctctat 2154961 cactgattca tggttgtctg cttcacttga gacgagccgt tcatccatga acatcacctt 2155021 actttaatag tttttgtaat gcttttttca catattggtc tgttgtcagc ccaatttctt 2155081 ctttaaggtg aggaagcacc tttttgattt ctttttcagc atatccgaga accctgaggg 2155141 cttcaagtgc ttcttcaaga gccgtttccg ctgtttgctt ttcaagcctt tcttcatgat 2155201 taaacagatt ttcaatcatt tcaggcacaa catctgccag ctttcctttt aaatctagaa 2155261 taatctggcg tgcggttttc tttcctactc caggaaactt gaccaaaaaa gcttcatctt 2155321 cattttcaat tgcttggatg accgctccgg gatcacccga gcccaagatg gcaagtgctc 2155381 ctttcgggcc aattccggtc acgtttaaca gctttgtaaa gagcgccttc tcctctcttg 2155441 ttgaaaaacc ataaagcgaa aaagcatcct ctctgatatg atggtatgta aaaatcgttt 2155501 cttggcttct ctccttatat ataaacggat tcggcgtgaa aatctgatag ccgatgccgc 2155561 cgttctctat gacaatatat tggggagata cataatcaat cgtcccttta acaaattcaa 2155621 tcacgcaaat tcacctcttt gactgttctt cattgtacca taaaaacagc caaagtctta 2155681 tagaaaagtt aacatatgtt cgcttctctc tcattctttc acgaaaaaaa agacatgaat 2155741 acatgtcttc aatcagcgga cgctacccgc tgtatgtctt catatgttcg atgacatcct 2155801 caaactccgc ttttgtccga aatggaatgc ctttcagcag atttttttgc atatggcttt 2155861 ccagcctttc taaatcaatt tgaaaaaaag actgaattgg ttcggaagct ggctcaggcc 2155921 gcccatgaaa agtggaaatc actccattat ccgatacacc gatatacccg ttgaccttgc 2155981 tgagcggaga aatatcgtcc atttgcttcc ggaagagcac atatcccttt ttttgttcca 2156041 ctagcgtcca tccggcataa gctgcccaaa aatcatccat agaaaacact ttttcatgct 2156101 tatgctcaat gctgacatcg ccgtccaaat acaccttttc aagctgcaca tgcacctgca 2156161 gcggctcata gtgctccact tccgcgccaa gtgcgcggga aggagctcct attaaaaata 2156221 ctgccgctga gcaaagaatg cccagcaaaa gatacgccgt gctgaatcgt ttcaccctct 2156281 acacctcttt gcacacgttt atgattagtt tgaccaaaga ggctactgct taaccgtttt 2156341 atcaaaattt gtctgcacat tttccctgac aaaccgttcc tccgtataca catctgtgct 2156401 ttgctcagaa attgtcaaga atcgcgtcag aaaggcactg aaaaaataca atgccgcaaa 2156461 gatccaaatc acgccacctg caccgagcgg cccaatgaaa agactcacga tgcccggcgc 2156521 gataaacgca cataaaccag atcccaaatt caacactgac atggcagcac ctttattatc 2156581 aggtgcaagc gtcggcaaaa gcgcgcttaa tgggacgtac cctgctaaag ccgcgccgta 2156641 gcagcaggcg ataatcatga gcacccaata ctgatgcccg atcagctgag gcgtgtaata 2156701 cagcgccagc gtaaaaatac cgcatccgac accgccaaac cacatgaccg tattgcgcca 2156761 gcctagttta tctccgactg caccgaaaat gatattaaac acaatattca caaaaaacag 2156821 cgtcccccat atttgcagcc attccgaaac cgaatacccg tatcgtgcta aataagtagg 2156881 aagaaagatg gcaaatccaa attgtcctat cgcattaatc gtcttgacca ctccgccgat 2156941 gcctacctta gggttttcaa acataatcgt aaatgccttc gacagttctt tccatttcgg 2157001 ctgatcttgt ttttgtatcg gagtaaattt atctttgtta aaaaataagg caagaattcc 2157061 gcctgccgcc acaaacagta aagcgctcca aagcgtattg atttctccaa aggccggaac 2157121 tgcatagctg gaatagaacg gaccgagcac gttaaggccg cacgtaaaca taaaccaaaa 2157181 ccagccgacg gcttttccaa gaatattttg agaggtgctg tatgacaccc atacgagaaa 2157241 agagtatgca aacagcggat atcccaagcc tctaagagca tagctgccca agagagccgg 2157301 ataatacata tgaggaatcg cccagccgat aaaagcggcc gaaccgagga taaatgcaag 2157361 caatccgaca gtcatcgttt ttctcggccc ccaagtttgg acaaacgttc ctgaaagcca 2157421 agctgagatg gtgacagcaa tgccgtacat ggtaaataac gatgcggatt gctgcatact 2157481 gagaccatga tcaacgagaa aaggagacag ccagccttgt tcgaggccgt ctccaaccat 2157541 aaagatgaca acgccaatat aaccccaaac catgtgagaa ggaattccga ttttgttcaa 2157601 aacatttcct ttagcatgta ctgtattcat tttctccacc gcctacttaa agtatcaatg 2157661 gagtatatac ccaagcttgc tgaattgtaa tcctgttaga ttaaaaagcg attttttcag 2157721 tgtgctcaat gctaacaggc atgccaaaag caagcgattg ctgtgctgct ctggcgatcc 2157781 tcccggcctg taaaccgtca ttgccggtgc agggagtctc ctggtttgtg ccgatcgctt 2157841 ctgcaaaacg gagaatctcc tcctcatatg aatccttata gcgttcaagg aaaaagaaat 2157901 gcggtttatc cttcatcaca aaatcagctg ttgacacctc aaccgttgtc ggcctgctat 2157961 tgtcagccgc tgcagagcct ttcgtcccga aaacctcaac ccgctggtca tatccgtaca 2158021 cagcttggcg gctgttatca atcacagcca tggcaccgtt ttcaaaagtc agtgtaataa 2158081 cagctgtatc aatatcaccc agctccgcaa aagaaggatt caccaaagcc gcccctttgg 2158141 catacacttc cgtcacttcg cttcccataa tatatctggc catatcaaaa tcatggatcg 2158201 acatatccat aaacaatccg cctgacgtac ggacataatc tatattcggg ggttctgggt 2158261 cccgggacgt gatttttaat aaatgaggtg taccgatttc accattttca acaatcgttt 2158321 tgattttctt aaaatgagga tcaaagcggc ggttaaatcc gacttgaagt gttaccccgt 2158381 gtttccggac agccgcaagc gcttcactcg tttcgtccag agagaaacta acgggcttct 2158441 cacaaaatat atgctttttc gcctcggctg cttctttgat catctgtgca tgtacggctg 2158501 taggagagca aataaaaata gcatcaatat caggatcatg taataaatca cgataatcag 2158561 aggttatgta ttcaatctga tgactgtcgg cccagctttt tatacggctc gcctgaatgt 2158621 cagagattgc ttttattttc atgtgaggaa tccggcttat attttgaaca tgaagtttgc 2158681 cgatgcggcc tgcaccgata atccctgtca caatctgttt tgtcatggct tcttccccct 2158741 tgatcattca cgaaagcgct ttatttaaaa ttaatactat cccatttgta agcgcttttc 2158801 aagaatggaa attaaacgtt ctatgtctct tttatcacaa ttcatgctta taagtagcct 2158861 tcttcttcaa gaccagatac actagaatta ggctcttttt cctgaacagt ttatgatttt 2158921 cctataaaca gctgcataaa atagagcaaa gaaggtgaat gaaatgctga caaaagcaga 2158981 ggcactggcc cataccgtca tataccgcaa gaacagcaga tttgataaag tcaaagagaa 2159041 atccgaggaa ttaacactaa tcggcaaggg aagaagcgcc tatgtgtttg ccttaacaga 2159101 aggcggtcga aaaatggcgc tgaaagtatt ttttccggaa tatcaagcga cagcagtcaa 2159161 agaagcagcg atctatgaaa aattagccgg gtccgcattc tatcctgaca tttacgaaac 2159221 tggcgattca tttattctca tggaatatat taaaggtgaa accttttata actgtctgaa 2159281 gaaaggcatt gcaatcagtg atgacatgat tcagcaggtt gaagaagcgc tttctgacgc 2159341 ccgggcagcc ggactgaacc cgtcagatat tcatttgcgg aatctgatat tgacagaaac 2159401 cggggcggtg cgggtgattg atgttgcgag atttgagcag acaaaaacat gcacgcagtg 2159461 ggacgactta aaatccgcat atcatgcact ctacaaaaaa ccgatattcc ccaaaaagat 2159521 tccgggtttt tggctggaga tcatcgcatt tttatataag aaagattggt ttcaaaagca 2159581 tttcgcacag cggaaaagaa aatattctta aatcaaaaag gcagccgcac aagcggctgc 2159641 ctttatcatg tattttttac tttctgacgg cagaaatcag tttcatttgt tcaggcgaca 2159701 gcttaattcg atagcctctc acagttaagt agaccgcttc tgggtccttc tcgccggaat 2159761 gacaatacgt tttttccatt tctgtctccc ctcacccttt attggcttta tttcatctta 2159821 tcattgcttt attgaggtaa ttttaaagaa atgtaaagat tatatgaatc cgatatatag 2159881 taaaatgaga gaaaaaaagg gagagagtca cattaagacc gaaaacacct tgagcttaga 2159941 tgcagccaga ggtgaacttg taaatgaaaa aacacttgtc aagagaacaa tctactggaa 2160001 ttacccggac agccgcccag cagtgacgtg gatcaatcac aatacagtga aaatcggcaa 2160061 tcagacttta catcttgata ctgatgaaac gtatgattgg cgaaaagatg atcattggat 2160121 ccgtgaagaa ccgccgcagg cgtcagtgag gtgatgaaac atgaataaga tgaacggaac 2160181 aaatgatgaa aagcatttca atcattttgt gattgcttta tcctttatat acggtttgac 2160241 tgaactaggc tatttgttgc tgaaggattt tataacaatt gccataagtt tgcctctgta 2160301 gaaaaacgca gcgtagtcga tacgccgcgt tttttctttt tcccttcctc ttcttattga 2160361 taattacagg tcatataatg tgacaaatcg attgtagaaa tagttcgatt agaccaaaat 2160421 cctttttata catgtattcg aatttgaagt gagggggaag cttgatggca gattttgttg 2160481 ctagtttgaa tgcggtctta tggagtacgc ccgtcattta tattttattg ggaattggat 2160541 tcgccttttc aattatgacc cgttttttac aagtccgaca tttaaaagaa atgattgttc 2160601 agatgttcaa aggcaagagc tctgaagccg gcgtttcatc tttccaagcg ttatcgattg 2160661 cgctgtccgg ccgtgtgggc acaggaaaca tcgcgggagt ggcgacagca attgcattcg 2160721 gcggacccgg tgcagtgttc tggatgtggg cgattgcctt tatcggggcg gcgagtgcct 2160781 ttgtagaatc aacgcttgct caaatttaca aagtgaaaca agacggtcaa tatcggggcg 2160841 gccctgctta ttatatagaa aaaggcttag gcattaagtg gtttgccgtc ttatttgccg 2160901 ctgctgccct tattgcaatg gcctttctaa tgccgggcgt acagtccaac tccattgcgg 2160961 ctgggatcca aaatgcattc ggcatctctc ctttcgtcac agggtgcggt ctggttttat 2161021 tattagggtt cattattttt ggcggcgtca aacgaattgc caatgcggcg caaatgattg 2161081 ttccatttat ggccattgga tatatcctgc tgtctttgat tattattgtc atgaatgtgt 2161141 ctgaattgcc tgctgtgatc tcattaatat tcaaaagcgc cttcgcattg gattccgctt 2161201 ttggcggctt gatcggtatg gcgatttcct ggggcgttaa acgtggcatt tactcaaacg 2161261 aagccggcca gggaacaggc ccgcatccgg cagctgctgc agaggtttct catccggtca 2161321 agcagggact ggttcaggca ttttctgttt atattgacac cttgtttgta tgttccgcta 2161381 cagctttcat gatcttgttt accggcatgt acaataccca ggctgcagat ggttccttta 2161441 tcgttcacca gcttaaaggc gtagaagcag gacctggttt cacacaagcg gcaattgaca 2161501 gtgttcttcc cggattcggt gcaggctttg ttgccatcgc tttattcttc ttcgctttta 2161561 caacaattat ggcgtattac tacatcgcag aaacaaatat cgcctattta gcacgaggca 2161621 gagaaagcaa atgggcgatg cttggcttaa aactgattat tttagccgcc acgttctatg 2161681 gtactgtgaa aacagcttca cttgcttggg cattagggga tgcagggctt ggcattatgg 2161741 tatggctgaa cgtcattgcc attgtgctgc ttgccaagcc ggcgctcctt gctttaaagg 2161801 attatgagcg ccaaaagaag cagggcttag acccgatctt tgatccaaaa gcgctgggta 2161861 tcaaaaacgc tgatttctgg gagaaagaat acactcatga aagtgaacgt gtctcctgaa 2161921 catactaaaa ccggcccgat atgacctcgt gccggttttt tatgaacgat agtttgtata 2161981 cacttcttga acatcatcgt catcttcaag gacgtctatt aatgtttcca gcttctcaac 2162041 agcctgatca tcggcttctg cataggtatt gggaagcatg gtcacctccg ccgaagaaat 2162101 tagatatttc gattcgaggg ctgttttcac ctcttcaaaa tgctcaggct ctgtgaaaac 2162161 ctcatatagg tcttcttcaa ttcgcagctc ttctcctcct gcttcaagca catcaagcat 2162221 gagctcatct tcttctattt gccgttcagt acggtctatc gtaatgaacc cctttcgttc 2162281 aaataaaaag gctacacatc cgctttctcc cagacttccg ccatttttat taaaggctgt 2162341 ccgcacattt gacgccgttc ggtttttatt atctgttacg cattcaacca tgacggcaat 2162401 ccctgaaggg ccgtagcctt cataggtgat ttcttcatag ctgcttccgt cttggcctcc 2162461 cgcagctttt ttaatggccc gatctatatt ttcattcggc atattggcgc cttttgcttt 2162521 ttcgatgaca agacgcaatg ctgaatttgc ttctggatcc gctccgcctt ctttcgctgc 2162581 cacatagatt tcttttgcca gcttcataaa tattttcccg cgctttgcat cctgtgcatt 2162641 ttttcttttt tgaatgtttt tccacttgga atggcctgcc atgttttcac cttcttttac 2162701 attttctatg tacactttaa tgggaaatgt tcgctgatgc aaagaaaaag gctgccgaat 2162761 atcacttccg gcagcccttc cttcctagcg gttgttcatt ttatgaagtt ttctgaacag 2162821 ccctttatct gttgatactt ggacgtcacg gccatttgca tagttgcgcg ctgcttttac 2162881 aacattatct ctgtcagact ttgtgaactc tctgtggctt ttgactgcga taactactcg 2162941 gtcatccgat accataactt gtgtgtcatt gacgtttttc acttgtttca cacggttggc 2163001 aatttttgca gccagtcttc tgttttcttg gttgtcatac ccgttgttcg ctgcattccg 2163061 attcatgttt cggttattcg tgttgttata tgttccgtca gttgccaaag gaacacgatc 2163121 gtcagcagta acacggtcac ggttatttac attcgtggtg tttcggttac cgtcgttctg 2163181 atcctccatt aattcagaaa caggaccatc gtggtcgatt ccgtctccct gtctatcggc 2163241 gtcattttca tttgtataat atccgattgg acgggtattg ccgttattgc gcgtatcatt 2163301 catagcatta tcgtttgctc cgcatgctgt taagccggct gtcattagaa tcaggctagc 2163361 gatcgtcatt tttttaccca atggaaaaac cccccgtgga cgaattgagc atgtttgctc 2163421 gcttttatca tgtgcgtatg gggggcatgt taagcgtgtc agttctctcc atttggcagt 2163481 gatctgcttg aaaacaaaaa aaggaacgat ttacatcgtt ccgaacgatc actcattttc 2163541 ttcttccgga cggccaaaca tttggtttac agaaggctgg ttcgtcattg gcatagaaac 2163601 tcctgccgaa tatgggtttg gatttgggtt agctgtgcca tatggcatat tagggcttcc 2163661 ataagctccc attcccgaat ggccaggtgc agagaaatat ggctgatgat caccgtcaca 2163721 gccgcagtcg tcatgatctt tgtatggcat gtaaccatga gccgcagcag gctggtatgc 2163781 tcccattact tggggagtgc cgtaataagg gccatacggc atatgtccat acggagatcc 2163841 ataagccgga gatgcgtatt gcggcgcacc gtatgaaccg taatgtccgt gatggctgtt 2163901 ttcatgatgc tggttttcat aacccgggtc atactgaggc gatacaaagc ctggctggta 2163961 tccatgcatc ggatgcattg gataagcttg tgccggatag tacggatagc ataatcctga 2164021 tcctggaaga attggcgaaa caggcaccgg acacggtacg aaatgagccg gataatgata 2164081 ataaggctga acagccggca tcggcatatt cggaactgtg tgatgaacgt tttcctcttc 2164141 tataccgcct acctctggcg cctttggcat attaggcata ttcggataat ttgcattttc 2164201 catattactc atagcctcct gttgtggaaa ttggtcttgc atatgataca tatgatccat 2164261 atttccgtca tgatgttttt tcggctcctc cggtttagga ggcgaccaag gctggaaaag 2164321 ctgtttcata tcataataat cgttcacatc agcttcaggg tacacatttt cctgcaaatt 2164381 aggcatcggc gggacatacg gcatggactt cttttctttc ggctttgtgt cttctacatc 2164441 gacaacggat ttaggcttct ctttcgcata tggatgttct tgcttcacac tcccggccgc 2164501 aggacttttg cccgcttttg gctcttttct gaccgggact ccttctgacg gcacttttat 2164561 tttcattcca ggcatgatta agtctggatt gctaagctgt gtattgagtt ttttcacttc 2164621 ctcaacatcg actccgtact tttcagctat tttccagagc gaatcgcctt tttgaacgat 2164681 atggattttc aacgttttcc cctcctatgc aaaacgtgaa cagttcagct gtgattacaa 2164741 tatgtttctt cacaacatat gcctgaacaa aagaagttat gagtaaagga agggaaaata 2164801 tttctgatct acgtgatcga aagcattcga ttcagggcaa ggagtgcatc ttcctgaatg 2164861 gcttttggca ccttgatgac gcctgaaggt tctccttttt caatttgttc cagcgaccac 2164921 aacaaatgcg gcaaatcaat tcggttcatt gtcaggcaag ggcacatgtc agggttgagt 2164981 gattcgattt gtttatctgg atgctcgtga atgatccgct gaacaagatt catttctgtc 2165041 ccgattgccc acttgcttcc cgccggagcc tggttgattg tgtcgataat atatttcgtt 2165101 gatccgttat catcgcttag tgtcacgact tcgtgtgaac attccgggtg cacaatgatc 2165161 tgaatgtcgg ggtctcgctc tctcatatca tggatatttt tagtggtgaa tttctcgtga 2165221 acagagcaat gccctttcca caaaatcact ttcacattcg tatgcccgga ttcagctact 2165281 aattcatctt tcatcggatc ccacacagcc atatcttcaa gcgcaatgcc cagatcataa 2165341 gccgtatttc tccctaaatg ctgatcaggc aaaaataaaa ttcttttttt ctgtgtaaac 2165401 gcccattcaa gcactttttt cgcattcgaa gaagttacag ttgctccgcc atgctttccg 2165461 acgaatgcct tgatctccgc agtggagttc acataagtta aaggtatgat cgtatctcca 2165521 aatatatgct gaagcttctt ccatgcccta ttggtctgct gcatgtcagc catgtcagcc 2165581 atagaacatc cagctctcat atctggcagg acgaccgttt gctgctcgct tgtcagcata 2165641 tcggcggttt ctgccataaa gtgaacgccg caaaatacga tataatccgc ttctttgttt 2165701 ttttccgcta cttgggccaa ttgcagggag tcgcctgttt ggtcagcaaa ttgtatcact 2165761 tcatcctttt gataatgatg gcctggtata aagagcctgc tgccgaactt tttcttaatg 2165821 gcggcaacgc gcgtttccat atcctttctc gatagttctt tataactttc gggcatcata 2165881 tcattcgatt gtttgatcac atcaagaatt gacataacag cattcctcca cagattcatt 2165941 tgataacgta acatccatgc tgatatctaa acttttgacg gaatgagtca gaaatcctaa 2166001 tgaaatataa ttcacacccg tccctttaaa agcaggcaaa gattctaacg taatcccgcc 2166061 agaggcttca gtttttatat tagccggtgt gagctttgca aaatgacgga ccgtatcagg 2166121 cggacagttg tcaaacataa taacatccgc tccagctgca attgcttccc gcagctgttc 2166181 ctccgtttca atttccacct cgatatttac catgtgccct gcggcctgac gggctttttt 2166241 gcacgcctct aaaatagagc cgcatgctgc gatatgatta tctttaatca tgatgccgtc 2166301 atacaaaccg aatcgatgat tatacccgcc gccggctctg acagcatatt tctccagcat 2166361 tctgagcccc ggtgttgttt ttctcgtgtc acaaatttta atctgttcat catccagaca 2166421 ccgaacagcc tctcttgtca ttgtcgcaat tcctgacagc ctctgaataa gatttaatac 2166481 gacccgctct cctgaaagga gcgcagctgc gggaccgtgt aactcggcaa tcacttcacc 2166541 tttatgcaac atgtccccat cttttttgtg taaaatgctt tgaacatttt cgtccaataa 2166601 cgaaaagcct tcttttatga tcgctgctcc tgcaaaaata ccctctgact ttgcaacaat 2166661 ctccgcttca cagctctgtt ctccaaaaat agactgcgat gtaagatccc ctgtcccaat 2166721 atcctcaaga aaaaagtgat tcagtaattt tttcagctgt aaatgattca ttgttccaaa 2166781 tcccctcgtt ttttctgatc ttcgttcctt tttttgtatg gacaatttgt cttccttgcc 2166841 agctcacctc agcatgagga aaatcggtgc ggaagtgagc ccctctgctt tcctcccgca 2166901 aaagcgcaga aaacgtcatc agctttgcag tttgccatag atgagaaagt tccatctgcc 2166961 gaattgtgat atccttcaca tttacttcct gaaaaggcag cgtatgaagc cagatgctaa 2167021 gctcaatcaa actgctttgt tcccgcagaa tagacatgtg gcttgtcatt ttgctttgca 2167081 gttcatgccc ctctatatcc ggcacctcgt agaagacact ggtttctagc cctgattgat 2167141 attgcctgtt ataaaccggt ttttggataa tatgctctgc tgcccttttt ccaaatacca 2167201 gcgcttccaa taaagaattg cttgcaagcc ggtttgctcc atgtaaaccg gagcatgctg 2167261 tctcgccaat cgcataaagc cccggcactg tcgtttctcc ccagcgatta actgaaacac 2167321 ctcccattaa gaaatgcatt cccggagcaa caggaatttt tccgctgtgg atatcaatcc 2167381 ctgctttttc acaaatagcg gtgatggtag ggaaacgcgt ttcaaaatca gaaatcgcac 2167441 tgaagtctat ataaacgcga tttccttttg ccatttcttc gtgaataacc cgtgagacaa 2167501 tatctcttgg agccaggtca cctaaaggat gccgttcagc cataatcctg cggccgtttt 2167561 cgtctactaa acatccgcct tcccctctga cagcttctga aacaagcccg taggaaacac 2167621 catttttcac aagcagtgtc gggtgaaact gagtaaactc caaatccgtt aattccgccc 2167681 cggcccggta agccagagaa agaccgtcac ctgtgacagt gagatcattc gtatggtgaa 2167741 gaaacaggtt tccacagccg ccggcagcca gcacaacttc gtctgcgtgc cttaccttga 2167801 gccgcccttt gctgtctttt gtcatgacgc cgatacatcg tccgtcctct ataagcaaat 2167861 ctgctgccgt ttcattctcg attaacttga ttttgctgtt gatccgtttg agcaaataat 2167921 cgataagcag cctgcctgtt gcgtctccgc ctgcatgaaa tatgcggttg tatgagtggg 2167981 ccccttctct tccaagacaa acaccgcctc gttcattgcg gtcgaatgga aatccacgct 2168041 ccaataggct ttgaaccatc atttttccat catgtaatac gtctgctaca atagctagat 2168101 tattatggcc gcaccctgcg tataacgtat cctccagatg ggcttcaatc gagtcatctt 2168161 ttgcataggc cgcagcaatc ccgccttgtg catagacaga attgctgttt ttgacgcttt 2168221 tttttgtgat aacagtcact tcgtatgagg gcgggaaagc tgcagctaag gaaagtgccg 2168281 ccgcccctga accgatgact gcaatcgtct ttttagacat atgccatcct cctgttgttt 2168341 acacctgtct tgacacctat atttacacaa ggataaaata aactcaagag ttttttatgg 2168401 agaacggatg gaggaagacc ggatgattta tttagattat gcagcgacaa cgcctatttg 2168461 tgaggaagcc cttactgtat atcagaagct tagtatggat atgtacggaa atgccagcag 2168521 cctgcatgat gcaggaggaa aagcaaagca catactggag tactgccgtg aaaaaatcgc 2168581 caacatcatt ggcggagaag caagcggcat ctattttaca agcggcggca ctgaatccaa 2168641 ttttctggcc attcaatcat tgttaaacgg cctgccaaaa acgaaaagac attttattac 2168701 gactgccatg gagcatcagt ccattcataa ttgcgctgct tttttggaac agcagggata 2168761 tgatgtaaca gtcattgaac cgaatgaata cgggcttatt accgaggaaa tattactaac 2168821 ccatatccgg ccggaaacag gccttgtatc tattcagcat gcaaattctg aaaccgggat 2168881 cattcagccc attcaacacc tgtcttcata cctgcacaat aaggggattc ttcttcattg 2168941 cgacgctgtt caaacgtttg gaaagatccc gatcaataca aaaaatctgg gagtagatgc 2169001 actctcaatg tccagccata aaatccacgg tcctaaagga gtaggggcgg tctatatccg 2169061 gccggatgtc ccttggaaac ccgtttatcc tctgactact cacgaatacg gattcagagc 2169121 cggcaccgta aatgttcccg ggatcggtgc cttcactgcc gctgcagaat tgatcgtaag 2169181 cgaaatggaa aaacagatat cccgcaatga ggcattaaga acatactttc tagaccaaat 2169241 ccgtattcgg tctctccctg taacccttgc agcagacact tcgaaagcag aatgtcttcc 2169301 gcatattata gggtgttttt ttcactcatt tgaaggacaa tatgttatgt tagaatgtaa 2169361 tcggagtaat atttgcattt caaccggcag cgcttgttct gcaggttacc acggtccgtc 2169421 tgaaacaatg aaagcattaa gaaaaaccga acaagaagct ctgcaattta tccgcatctc 2169481 ttttggcagg catacaacag ctgaacagct ggaacagtta ttacatacgt ttacagtgct 2169541 ttgggaacaa aagaaaggag aatttgatat tgaccgaaga attaaagcta atgggcgcca 2169601 acaggcgtga ccagcttctt ctgtggctga aggaatctaa atcaccgctg acaggaggag 2169661 aactcgcaaa aaaagcgaac gtctcaagac aggttattgt acaggatata tcgctcttga 2169721 aagcgaaaaa tgtaccgatt atcgccacaa gccaaggata tgtatacatg gatgcagccg 2169781 ctcagcagca ccagcaggca gaaagaatca tagcatgtct gcacggtcct gaacggacag 2169841 aagaggaact gcagctcatc gtcgacgaag gcgttacagt aaaagacgta aaaatcgagc 2169901 atcccgtata cggagattta actgcagcca tccaagtagg cacccggaaa gaagttagcc 2169961 atttcatcaa aaaaatcaat tctacgaatg ctgcctactt atcacagctg accgacggcg 2170021 tgcacctgca tacactgaca gcacctgatg aacatcgcat cgatcaagcc tgccaagccc 2170081 tcgaagaagc cggcatttta attaaagact aaaaaaagcc ctctagtggg ctttttttat 2170141 aattggtaag actggtatgc acccagaagc ctcactttgc agccgagtgc ttcaagctcc 2170201 tgcatggccc ctggaatcaa tacatcatca aacgctttct caatatcaat aataaagaaa 2170261 taatggccta atccggtttt agtcggacgt gactcaattt ttgacaggtt taaatttctc 2170321 caagaaaatg cagacagcac tctatgcagc gccccggact gatcatcctg cggcagcatg 2170381 accattaagg tcgttttggg cctagagctc aattttgaat tcacttcaaa agatatgttt 2170441 tcatcgggag acaggataac aaatcttgta tgattgtccc tataatcctg tatatcccgt 2170501 ttcacgattt ttaattcgta tgtagaagct gccatatcat tggcaatgac cccgatattc 2170561 agctcgggat ggtcactgac aaactttgct gccgccccgg tagaattggc gtattcatat 2170621 ggaacggaag gaaaatgtcg atgaagaaat ttatggcatt gcgcaatcgc gtgtgaatgt 2170681 gagtaaattt tgtcgagctc tttccatgca ttctctcttg agggatggac gagcaagtgc 2170741 tggtgaatcg gcaacgtcat ttcacccacg attggcaaag gctgttcatg tattaaatag 2170801 tctattgtta gattaacaga tccttctaaa gcattttcca aaggaacaaa agcaaaatca 2170861 acttcgcctg caacggctgc atctatacac tccggaatgg tgcggtaagc aacatgttcg 2170921 gcgccgtttt gaaaacaaga actgactgct agatgtgtaa atgtagctgc tggacctaaa 2170981 taaccgactt tcatgacgat tttctctccc ttatgcacct gaacctaata tttcaacctt 2171041 ttctacaaaa tcaaacttcc tgagcttatt cattaatgta tgaatgtctt cttccattgc 2171101 cgacgtactg atagacagtg tcacatttgc tctgccttga agcggaatgg tctggtgaat 2171161 ggaaagaacg ttgcttccag aatcagctac cgcctgaaga agctgagata acgcacctga 2171221 cctatcctcc aaatgaaaga aaagtgtgat aatttgttct tttaccatgg tgtagaatgg 2171281 aaaaacagca tccctgtatt tataaaacgc acttctactt aaatcgacct tttgaacggc 2171341 atctgctact gaatctgctt tttttcgatc aagcagcttt ttgacttcta atgtttttct 2171401 cattgcatcg ggcaatacat cttcacggac aagataaaat gtctcctctt tcatttgcat 2171461 ccccccttta aaatagagag cctggcacca ggctctcttt tcagccaaca ttgattaatc 2171521 aataaattca aattcaaatt ccagaagcct gattatatct ccatccttgg ctccgcgttc 2171581 tctgagtgct tcatcaacac ccattccgcg catctgtctt gcaaaccgtt taaccgattc 2171641 atcacgtgag aaatcagtca tcttgaataa ccgctcaagg ctgtctcctg aaagcacaaa 2171701 tacaccgtct ggatcgcgtg taatgttaaa tggcacttct tcattttcca tcgtgtacat 2171761 gacacggttt tgtgtaagct cttcctcgtc atacagcggg aattccggtg tgttctcaag 2171821 ctgattggca acctcaaaca gaagctcacg cagaccttct cttgtcaccg cactgatcgg 2171881 gaataccgga taatcatccg tcagcttttc tttaaaggct tcgagatttt ccgcagcctc 2171941 cggcatgtcc attttatttg caacgataat ttgcggacgc tcagtgagac gcagattgta 2172001 ctcgctcagc tcctggttaa tcgtaagata atcatcatat ggatcacggc cttctaagcc 2172061 tgacatgtca atgacatgaa caataaccct cgtccgttca atatggcgca aaaactggtg 2172121 gcccagtccg acgccttggt gtgcgccttc aatcagccct ggcaaatcag ccatgacaaa 2172181 gctgcgtccg tcatccgttt caaccatgcc gagattcggg acaagcgttg taaagtgata 2172241 gtccgcaatt ttcggttttg cagatgagac aacagacagc aaagtagatt ttcccacact 2172301 cgggaacccg acaagtccga catctgcaag cacttttaat tcaagaacaa tgtagcgttc 2172361 ttttcccggc tcgccgtttt ctgaaagctg aggcgcggga ttagccggtg tagcaaagcg 2172421 gctatttcct cttccgcctc ttccgcctct tgcaatgaca gcccgctgtc cgtgctctgt 2172481 taaatcagcg atgacctgtt ttgtatcatc gtctgtcaca acggtgcccg gcggaacttt 2172541 aatgaccata tcatcagcat ttcgcccgtg ctggtttttg gacatgccat gctcgccgcg 2172601 aatcgcttta aagtgttttt tgtatctaaa atccatcagg gtgcggagac cttcatctac 2172661 ttcaaaaacg acgtctcctc cctttcctcc gtcaccgccg gcagggccgc ctttcggcac 2172721 atatttttca cggcgaaacg caaccatacc gttgccgccg tcgccgcctt ttacatatac 2172781 tttgacctga tctacaaaca taatgtcctc cgttctaaac cgttaaaaac tccgctagtc 2172841 caacccaatt tcaatcagac attcgtgact cgtgatttca aaacgcatga tatcaacgtc 2172901 ctcatatcca ttctgccgaa tatcatcaaa agcagatgga tcggcaaagg cgccgtgaaa 2172961 atcaaggtac agaatcagct gtctgtcagg atgatccgtt tgaagcgaaa ccgttaaatg 2173021 attttcactc tctctgctga ctgcttgatc aaacagatga aacagctttc tcatcagttt 2173081 cgccagcttt tgatcataag ccgacaaatc cttaatttct ccgagaactt catattcaag 2173141 cgtcatataa tgggttttcc aattaaacgt aagaaaatca aacgccaaat gcggtgtttt 2173201 caggtttgag agctttgatt cgtgctttgc gtctataacc atttcttcaa tcatttcaaa 2173261 gacacggtca tacttctgta agcttaagtt tcctttaatc agctgcagct tattcatcca 2173321 atcatgccgg gaatggccaa gcagatgaat cagttcgttt gttaatgccg tgtcgcttat 2173381 attttcttct tgattttttg aaacatcctt cattttcgca ctcccaatca tttaatttct 2173441 tatttaggag tctgtataag tgtgtattat gaattataac agagaaggct ttgttagaaa 2173501 aacaattgtt tttcccagaa atatcatgtt ccttttttct ggctttggtt gatttgcagc 2173561 caggcagaac attttatgta ttactgcttg gggaacatat ccagtgggtt tgagatgttt 2173621 attctcattc ttggcggggt ctgctcgcac atactctgca tttcattcta ggtgtttact 2173681 ccgcatattg caaaaaaaac tccagtcatc atcgaccgga gttttttgaa tcattattga 2173741 gctacaggat atacgctcac ttttttgcgg tcacggccga aacgttcgaa tttaacagtt 2173801 ccgtcgattt tcgcaaatag agtgtcatct ccgccgcggc ccacgttttc acctgggtaa 2173861 atttttgttc cgcgttgacg gtaaaggata gaaccgcctg ttacgaattg accgtcagca 2173921 cgtttagcac ctaaacgttt agcctcagag tcacgtccgt tctttgtaga acctactcct 2173981 tttttagaag cgaaaaactg aagatctaat ctaagcatgt agctcacctc ctatattatg 2174041 tttgtggtca cacgcaagtt gtctttgtaa tcccgttcga ttgtctccag cgaaacaatc 2174101 atgccttcaa tcagcagctg agctttttgg cgtgcctctg gatcaagaga ttcagggaat 2174161 tcaaaataaa aataaccccc gtcctctcct atatcaagaa gcggctcgaa gcccgcgagc 2174221 acaatgaccg cgttaacggc cccaaacaca acggctgtca ctccggcaca aacaagatct 2174281 tgtccatgtt cagcaaaatt cgcatggccc gtcatttcaa aagacaatat gcctttatca 2174341 tgagaccttc tgattgttgc ctgaatcatg cttacgcgtt gattttttcg atcgtcactt 2174401 tagtgtaagg ctgacgatga ccttgttttt tatgaacgtt tttctttggt ttgtatctga 2174461 aaacagtgat ttttttcgcg cggccttgtt tttcaacttt agccgttact gttgcgcctt 2174521 caactgtagg gttgccgact ttcacgttgt ctccgccaac aaacaaaacg tcttcaaaag 2174581 taactgtttc acctgcttca gcagcaagtt tttcgatgta aacagtttgg ccttcttcaa 2174641 ctttgatttg tttaccgcct gttttaatga ttgcgtacat tctctgcacc tcctattaga 2174701 ctaagactcg ccagatacca gggggctgta aaagctctta acacctgtac tgagcggttg 2174761 tagcaatggt gctacatcca taacattaaa aaatatacca aaatacaagg cgtttgtcaa 2174821 tcagttttag tagggcagaa gcagttcctc catggaagaa ttcgtccgct tatcggcaaa 2174881 gtaagcgtgc agcacttcat tctcgtcaag ctggctgagc ttttggcctg atttttctat 2174941 aataatcgga tgcttacagc cacgtttgaa ctcggccatc acatgataga ctttatcctc 2175001 cgcctttact gtcagcggca gaagtttctc aagctccctg ttttttccgt aatacctttc 2175061 gaggagaaat ctcacatgga tatagtgcct ttgccgatat tcctcaaaca aggaaacagc 2175121 cagaaagaca aacaaaaccc atgcgctgat ttgcagagga atcacgaata aaacccagca 2175181 cccgagcagc aggcagaagc agagcgacgt ttttagatta agccggtgag ccttttgaaa 2175241 aggcagctgt ttggaaaaca acaaaaataa cagttttcct ccatccagcg gccagatcgg 2175301 cagtaaattg acaaataaga tagaaagatt ataaaaggtg aagagttcaa aggtatgctg 2175361 atgaatcact gagacttctg caagcatcca ggcggcaaac tgaagccaga tgtgctgaag 2175421 aggtccggca ataatgaccg caaactcttc ctttaacggc cgattcccgt gctcttccac 2175481 ttcgaccgtt ccgccaaacg gcagcaaaaa aacacgcttg attctccaag aaaaaaacac 2175541 agccagagca gcatgcccca gctcatgaat caatacaatc aggagcagac ataataatgc 2175601 tttcatatgg cctgtgagca agcccagcgc cgcaataatc caaagaaaag gatgcacatg 2175661 gatctttaag ataaggtcga gccatttatt caaatgaaat cacctgaatc ggatcaataa 2175721 atttatcgcc gtctttcatg gcaaaataat agaccccttt attatgatca tcaagcttaa 2175781 tcgaaccgag ctttttgcct ttatccacaa aatcatataa agcaacatcc acatctttga 2175841 gctcgccata gatactatag gtgttgtcag catgctgcac cttaaccgtc agtcccgttt 2175901 ggctgtcttt gctgacttca accacatagc cttcttttac gctatcaatc ttatcactgc 2175961 ttgtttcgac tttaattcct tccccattgt cctgaaaatc ctgctgtact ttcccggatg 2176021 caggcgcgat cagatctttg cctacttcaa tctgctgttc cttatttttg tgttcaggag 2176081 ccaggaaagc aagcggattt ccgaatttgg tttcgaacca atggcttgct gaagcaaatt 2176141 gaaattcagt ttcaaaggtt ttggctacgg cgggtttaat ctgactgacg ggtccaatgt 2176201 ttgttttata ggctatagct gaaacgagaa caaggcaggc cgacagaaga catttcagga 2176261 taattgaatc tgttttcacc aatgggtgtt ttccgttgaa tgttggcatg ttatcttcgt 2176321 agaccggaag tgttccatgc ttttcctgat ccgttaccat cacccaggac gggggtttct 2176381 gcttttcaga aactgtctga gtagagaaac gttttgagcc ggaaagctgc tttcttcttt 2176441 tctctaatcg ttttctgatt tcatctgctc tgtgactcat tgccatcatc ctttgcattc 2176501 gttgggtttg tacatcatat gtcttgtcca tggcaaatat tcggtttagt caagaacaaa 2176561 gcaggcaaaa acaaaaaaaa cctgacacag catatgcttt gtcagattct tctctttgat 2176621 tctatcacat taagatctta ctccgaaaaa tgacttaatc ttagccatca ttcctttgtt 2176681 ttgctcttca agcacctgta aaggaacaga ttcacctaag atgcggcggg caatattgcg 2176741 atatgcaatg gaagcgcggt ttttagggtc catcgcaatc ggttcgccat gattggaagc 2176801 tttaatgact tcatcatcat cagccacgat tccgagcaaa tcgatcgaca gatgctgtac 2176861 gatttcgtcg atatccatcg tgtcaccgtt tttcatcagg tgatttctga ttctgttaac 2176921 aacgagccgc ggcggttcaa tattttcctc ttgctccagc agtcctataa tacggtcagc 2176981 atcacgaaca gctgagattt caggcgtagt gaccacaatc gctttatcag ctccggaaac 2177041 ggcatttttg tacccttgct cgattccggc aggacagtct atgatgacat agtcaaattc 2177101 ctgtttgagc tcttggacca tgtttttaat ttgttcagga gcaacagctg tcttatcgct 2177161 cgtttgagca gcgggcatta aatagagcag atcatcgaaa cgtttgtctt ttacgagcgc 2177221 ctgatgcatt ttgcatctgc cctctacaac gtctaccaga tcgtaaataa ttctattttc 2177281 aagacccatt acaacatcaa ggttgcgcag tcctatatca gtatctacta agcatacgcg 2177341 cttccctaaa atggctaagg cggtaccgag gttcgcagat gttgttgtct tacctactcc 2177401 gccttttccc gaagttatta cgatagcctc acccaattca cattcctccc tcaagccttg 2177461 ttagatcagg tcttaaatga gccaaatgtt gaaggcgttc aatgaccata tttccgtctg 2177521 tatctaaata agcacattcc atttcgttcc ctttttgaat gtggtctggg gagcgattta 2177581 acacatgatt gattcttaat tgtgtcggaa gcatttcaga ggcggcgatg accgcttgat 2177641 tatttccatt gaatccagca tgcgcaattc ctttcagtga gcccagaaca aaaatgttcc 2177701 ctccggccct gactgttccg ccgggattca cgtcaccgat caggagcaag tcgcctttta 2177761 cctgcagcac ttggcctgaa cggacaattt ttgaaacaga aataatttcg gcttcctctc 2177821 ttatctgctg tgcttctttt ttagtaatga cttcactgtc aatagaatga acaaacaaat 2177881 ctttctttga cgcaatcaat tcggttagct gttcctcttg ctccttatat aaaaagcgat 2177941 ttcccagctt aacatgaacg ctgattttct ggccttttcc atcggtatat tgttcaattg 2178001 acagcatatt ctgaagacca tcgagaagct catcaaaaga acacgcatca tccagatgca 2178061 atgttagtcc attctttgtt ccttttattg ttacatattg ctgctttttg gtcttcacaa 2178121 tattcacctc aacaacatac tcatttcgtc aaaaaaagat aaaatccttt ttactcatct 2178181 ctcaattctt tctttagact cataaaaaac aatctaaatg gcagaacaag aataagagct 2178241 gctgcaatat ttaataaaat tgtcggtata aaccggtcaa gcacaaatcc gttaaacgtc 2178301 ataatgtctt tatgaatcaa agactgaatg ccgaatacgt aaaattcgag cagacagaca 2178361 gccagaactg ctatcaatat cactacaaat gcgtttgtat gcaacacttt aaacgctttt 2178421 gaagccaaat agcatagccc tgcaaaacca aacatgtaaa cgcctaatag acttgtatag 2178481 ttcatgtcat atagaaagcc aaaaataaat ccgtaaatca tcgcgtgttt ttggttgata 2178541 aaagccgaca tgaatatcaa tacaagcatc aaaaaacgcg gggcgagcac ttggtcatct 2178601 gtaacgaaag gaaaatgcac caaatctgta aaaatgcttt ccgcagaaaa aacaagcatc 2178661 ataacgaaag ggagaaggaa acgtttcacg atccttcctc ctctgtatcg acagtcggca 2178721 cgtcacggtt aacaacgatc acattattta aatctgtaag gtcagccgca ggttttacat 2178781 aagcaacctt cgttaatcca taggaatctg actcgatatc agtcacttca ccgattgtca 2178841 gcccttctgg gaaaacaccg cctgtccctg atgtttcaat aagatcgcct tttttcacgt 2178901 cttgtttatc cttacgctca ataattgtca tcttaagacg ttttttctct ttgtcatatc 2178961 cttcgatcaa gccgtagcct ttgctgcctt tttttccgga aatttttgtc gcgactctgt 2179021 tattgcggtc agtatcgctt aaaagctgaa cagcagacgt aaaattgtta agtccggagc 2179081 ttttgatctt gccgattaat gcgccttttt cgtttgtaac ggccatatct ttcgctacgt 2179141 tttgctgagt ccccttgtta atggtgacct gtttcgccca attatcaggg cttctggcga 2179201 tgaccgttgc taaaatcggc ttgtaatctt taatcgattt gacatggcca agctcgtcac 2179261 gcaaggattt gttttcttct tcaagctctt gaagcttggc ttcatattgt gtctgtccgt 2179321 caagtttttc tcttagacgc tcgttttctt tgtatgtgtt ttttaaatca ttgatgttct 2179381 caaatattcc tgcaaaaaat tcggcaggcg tatgaaaaat attttgaaat actcccgtcg 2179441 tatcgccgat cactttctca ggccaggtgg tattgcggcc gcccttcagc gaaaatccaa 2179501 tcatagccac caatatgata atacacagaa gtaatagcat taaccgctta ttcggcatcg 2179561 tgttacacct cttctattga actcccgatt atctagtttt ccctttgaaa agatggatgt 2179621 gctccagtgc tttccctgtt ccgatcgcta cacaatcaag cggatcttcg gcgataagga 2179681 ccggcatttt tgtttcttcg ctgatgactt tgtccaaatt gcgcaaaagc gctccgccgc 2179741 cggttaacac tatacctctg tccatgatat ctgctgcaag ctcaggcggt gttttttcga 2179801 gtgtgctctt cactgcttcg acaattgtag atacagtgtc gcgtagagcg ttagaaatct 2179861 cttttcctgt aatttcaatt gttttcggca aacctgtgag caaatcgcgg ccgcggattt 2179921 ccatgttgtc ggattcttca ggagcttctg cagatccgat ttccatttta atcgcttcag 2179981 ccgtacggtc accgatcatc agattgtacg tttttctgat gtagttgata atcgcgtcat 2180041 ccatctcatc accggctaca cggattgact gagacgttac gatgcctccg agggaaataa 2180101 tcgcaacttc tgtcgtaccg cccccgatat caacaaccat gcttccagtc ggttcccaaa 2180161 ctggcagatt ggctccgatt gctgcggcaa aaggctcttc aatcggatac gcgtcacgcg 2180221 ctcccgcctg tcttgtcgca tcgataacag cgcgttcttc aacagctgta atgcctgatg 2180281 ggacacatac cattacatat ggttttctgg caaacatgcc tttatttttt atggcctgat 2180341 tgatgtaata tttcatcatc gtcgccgttg tttcataatc agcgataacg ccgtctttca 2180401 tcgggcgaag agccaccacg ttgcccggtg tccgtccaat catatttttc gcatcatttc 2180461 cgacagcgac aatcgatttc gtatccgtct gcaaagcgac aactgacggc tctctcacaa 2180521 caattccttt tccttttaca aaaacaagcg tattcgcagt tccaagatct ataccaaggt 2180581 ctctagcacc aattccaaac atatgtatgt atcttccttt cttaaagcaa aaatacccta 2180641 aagggaaaaa ctcataaact ctattatagc ttaattcgac gaaaaaaaaa gtgttacaaa 2180701 tatccttttt cctttaaact cacaaatttt ttatccccga tcaccaaatg gtcaagcagc 2180761 tcgatgccaa tcaggtttcc gcattcaaac agccgtcttg tcacttcaat atcttccctg 2180821 ctcggcgtcg gatctccaga aggatgatta tgaacacaga taaaggaagc ggcagatcgt 2180881 ttaaacgctt ctttaaacac ctctcgcggg tggacaatag atgaattcag gcttccgata 2180941 aatacggtgc gtttatggat gacttgattt tttgtattta agtataaaca gacaaaatgc 2181001 tcctgggtta aaaagcgcat atcctccatg acaagattag cgccgtcttc cggggagcga 2181061 ataacgaaat gttcttcgtt ggctaattta tgaatccggc ttccaagctc aactgctgcc 2181121 agtatttgaa tcgcttttac cataccgatt cccgggatgc ttgacagctc ttcaaccgat 2181181 gcttccttga gcaggcgcag cccgtcaaat gagcgcagca gccggtttga caggtccaaa 2181241 acagattcgt gtttagtccc tgtccgcaat aatatagcca aaagttcatg attcgctaag 2181301 ttctcggctc cgactttcag gagccgttcc cttggctttt ctttcattgg gaaatctttg 2181361 agttttaatg gcagatcgtg tatgaccaag cactcctttt ctttcccttc ccgtttatag 2181421 aaccgtcatg cccttatatc aaaatggcga agagctctca ttgtttttga tataggaagg 2181481 cccatgactg aataataatc tccgtctatt ttctttacaa aaagcgcgcc tcttccttgg 2181541 atgccgtatg cacctgcttt atccatcggc tcttttgttt caatatatgt ccaaatctct 2181601 tcttcactga gggaccaaaa cgcaacttct gtcttatcat aaaaagtctc gctgtgattt 2181661 tcagcttgaa tgctgaccgc ggttattact gagtgacttc ggcctgaaag cctccgcagc 2181721 atagaagcag cttcttcttg atcctgcggt ttgccaagac attcgccgtc aaggcatacc 2181781 attgtatcag caccgataac gattgcatgc gggtggagat cagctacagc cttagctttt 2181841 tgttttgcca accattggac gttttcttct ggtgaaaagt ttcgatttaa tttttcttct 2181901 acttcactga caataatgga gtagggcagc tggagaagat cgaggagttc tttcctgcgc 2181961 ggagattgtg atgcaagtat tagcggtttt gtcatgttcg tcatcctttc agggtttgct 2182021 taagaaaaaa agatactcgt ttatcctacc aaatcacgag gcttgtcaca atttcagaaa 2182081 aataactttt tcatgacaaa ataaaaaaag cctgtcacta aaggacgaag gctcagggca 2182141 ctatctctta ttttacgacg gctaacagct cctgctgagc cttccacccg gcttcagcac 2182201 ttggatcctc taattccttt aaagcctgca aaatcgcttt tttctctcct gtttctgacg 2182261 cttttgtttc accaagcgac ttttctattt tctctacact cgcttttgta atgtcttcgt 2182321 cgagaatcgc ctttgctgca agctccgctg tttccttaaa agaatctgtc atatctgact 2182381 ctattgataa ggaaagctcc ttgcctcccc aggcttcaaa atcactgtcg attaaaacct 2182441 gtcctaactg ctgtgagacc tccttttcac ttgctaagcc tgcaataaca tacgtatacc 2182501 cgtcatcctt tgacagtgac acggcggaat atcctttttc ggtcaattgt tctgttaacg 2182561 tttcggcgcc cttttcattt gaaaattttc cggcttgcac agcgtatgtt ttgtatgtac 2182621 cttcagtttg tgccgcttgt ttttctgcgc ctgaggtttg tttatcagca gaagtatccc 2182681 ctgcttttgc cgtttggctg cctaaagaat cctctaaaga ggccggtgct gacgcttctt 2182741 tattccccga tatgtttaac gcgaataacc ctaatccagt gccaatgaca gccgcgaagg 2182801 caatcgtcgc ggccactctt tttaccggtt tggcagcccc ggtctttcct tttgcgtaaa 2182861 gctttgtttt tttcttttga aaaggaggaa caactttagg gtcctcttta aacaccttgt 2182921 cctcctcgga atcccaattg aattcatctt catcagggtg ttcctgggat gccgcaacct 2182981 cttgttctgc ctgtcttttt tcctcccaat ttgaaaatgt catgctttta ttcgcctctg 2183041 tctcaggcgt ctcttgttcg taaaccgtct cttcttttcc attaatcgtc accttgaggg 2183101 ctttttctgc ggctttactg ttttttttat tctttctttt tttcaattcc gcttcctccc 2183161 ttcatttgct tgaccgttct tgtcggcttt tcatgctaca cactttagca caggcaaaga 2183221 aaaaaagaac aagacttttg tcgccttgtc caaaaaacgt tcgtcaaatt tttcagcagt 2183281 cagcccaatg ccattttgat ataaaaagaa atgatagagt caccgtataa ataggctaaa 2183341 atgctccctg cggctatagc gggggcgaag ggaagcggct gccttttagc gagtctacca 2183401 gtcagaacag ctgccgctcc atataatgca cctatcaaaa ctgaaaagaa aaaggcagct 2183461 gccagcattt tcacaccaag cacaaagcca atcaccgcaa ataatttaat atctcctccc 2183521 cctactcccc catgggtgat tgcggcaatt acagccagaa acaaaaatcc ggctgccgca 2183581 cctaacaggc ctgcatacca ggaatcaagc ggagaaatca atctcgcggc cgccaaaaag 2183641 ggaagaaaga aaatcaatat tcgatttgga atcagcataa aatgaatatc tgtcactgca 2183701 acaataatga gaagagagat aaacaccaca gcgggaaaca gttccagcga tatgccaaag 2183761 cgtattcctg cggcggcaaa taaacacgct gtcacaagct ctgctgcggg atacataaaa 2183821 gaaatcctat gcccgcagct tttacattta cctttttgaa ataggaatga caggatggga 2183881 attaattctg caggagttaa tgttcgccgg caaaacgggc atgatgaacg gggcgcaata 2183941 atagatagat gtaaggggat acggcacccg gccgtatagt aaaaagaacc aaggataagc 2184001 ccgaagataa aaagaatgga tagcatagac aacacacctt tactcattga gttctggtat 2184061 ggattgtagc aaaatggaca tcctgagctc caattgggaa tattcaattt tacacatgaa 2184121 aaaaacggca gaatcttttt ttgattctgc cggagccgga tgcttttatt tcaacctttt 2184181 tcgaatgtca gaaataaagt aaagagatcc ggtaatcagc acaatttcat ttgagccctt 2184241 tttactttct atgaatttga ttacatcgtc tggatcttca ctccagcttt tattgctgat 2184301 ttcacttgca tcatagagat cttttgcaag ggaagcacgc gggaaatcaa aagaagcaaa 2184361 atgaatcgca tgagcaatgg tttccagtct tttaatcatg ttctgatacg gtttgtcctt 2184421 taacgcgcta aacaccacag aaatgcgtga attggcgaaa cgctgcttca tcgtttccgc 2184481 cagcttttca acaccttctt cgttatgcgc accgtctaaa tataccggag gatgttcctg 2184541 aacaagctct aaccgtcccg gccaagcagc cttcacaagc ccgctcctta acgcttcgtc 2184601 actgatatgg gcgatattct ccttattgag ccactccgca gccaaaatgg acaaagcagc 2184661 attttgtctt tgatgggtgc caatcagaga tgtccgaata tcttcatagc atttctcttc 2184721 cgttttgaat gaaaactgtt ctcctgcagg cagagcctct tcattgaaaa taacacatgc 2184781 atcatgcaat gactggaacg gcgcagcatg ccgttcggct tcatggcgga tgacctgtaa 2184841 agcttccggc tgggtaactg ctgtaacgat tggaatacct tctttaataa tgccggcctt 2184901 ttctcctgca atttcttcaa tggtgtttcc caaaatgttc atatgatcgt gtccgatgct 2184961 tgtaatcaca gttaagagcg gttcaaccac attagtagaa tcgaatctac cgcccagacc 2185021 tgtttcaaaa ataacaaaat cgaccttatg aaactctgca aaatataaaa atgcacaagc 2185081 tgtcataatt tcaaattctg tcggctgtcc gtattccgtt tgatcaaggg cttcaacgtg 2185141 cggtttcatt tgattgacga gtgctgtcca ttcctcatct gaaatcggta tcccgtttac 2185201 gctgatccgt tcattaaacg taataatata aggcgatgta aatgttccaa ccgtatatcc 2185261 ggcttcctgc agcatagaac ggataaaagc gacagttgat cctttaccgt ttgttcctgc 2185321 gacgtggaac gctcggattt ttttttcagg atgtcctaac cgcgccatca gctgtttcat 2185381 tcgaccaagt ccgggcttca ccccgaattt cagcctcccg tgaatccagc tgcgcgcatc 2185441 ttgatatgca gtaaacaatg ataatcccct cttttataag acaaggcggt ttctctagaa 2185501 accgccccgg cttttcatta acccttcagc tcagccattc gtttttgaac agcgtcacgc 2185561 ttcgccacat aatctttttc tttttcacgt tcttcatcaa ttacgtgtgc aggcgctttt 2185621 ttcataaatc cttcatttcc aagtttcttt tggacacgct caacttcttt tgtcagttta 2185681 tcaaattctt tttgcagacg ggcaatttct tcatcaatat tgattaagcc ttcaagcgga 2185741 agaataacct ctgctcctga gacaacggcc gtcatcgcct tatcaacagc ctcaatatcg 2185801 gtgccgattt taagcacgct cggattcgta aagcgttcaa catatgaacg gttcgcttcg 2185861 aggcgggacg ctatttcgtc tgtgcttgtt ttaatgtaca gttcaacctg cttgctcatt 2185921 ggcgtattga cttcactgcg gatattgcgc acagaacgga tcagctcaac aagaagcttc 2185981 atgtcagctg ccgcttcagt atcggtatgc tccggcacta ctgcaggcca ttgacttact 2186041 gtaatcgatt ccccttggtg aggaaggtgc tgccaaattt cctccgttaa gaatggcata 2186101 aacggatgga gcagacgcat cgtttgatca agtacgtaag caaggatgga acgggtagtt 2186161 ttcttagccg cttcgtcttc tccataaagc ggaagcttcg ccatttcaat ataccaatca 2186221 cagaaatcat cccaaataaa gttatataaa tggcgtccta cttcaccaaa ttcatatcgg 2186281 tcagcaagct gggtcacgtg ctcgatcgtt tcatttaatc gcgttaaaat ccacttgtca 2186341 gcgactgact tttcacctga cagatcaagc tcatcgtacg tcatgccatc catattcatt 2186401 aatgcaaaac gggaggcgtt ccaaatttta ttggcaaaat tccaggtcga ttccactttt 2186461 tcatagctga agcgcagatc ctggccagga gagcttccag tcgcaaggaa ataacgcaga 2186521 gaatcggctc cgtacttgtc aatcacatcc atcgggtcga caccgttgcc aagagattta 2186581 ctcattttcc ggccttgctc gtcacggatt aagccgtgga ttaaaacatc tttgaacggg 2186641 cgctcgcctg taaattcaat gccttggaaa atcatgcgtg atacccagaa gaaaatgata 2186701 tcgtaccctg tcacgagaac atctgtcgga tagtagcgtt taaagtcttc agccgttaca 2186761 tcaggccagc ccattgtgga gaaaggccat agcgcagaac tgaaccatgt atccagtacg 2186821 tctgtatcct gttcccaatt ttcgctgtct tccggcgctt caagtccgac atatagctcg 2186881 cctgtttctt tatgatacca ggcaggaata cgatggcccc accacaattg acgggagata 2186941 caccagtcgc ggatattttc catccagtgt aaatacgttt tttcgaaacg gtcaggcaca 2187001 aagttgacct tttcttcttt tttttgcagc tcaatcgctg catcagcaag cggctgcatg 2187061 cgcacaaacc attgtgtaga aagataaggc tccacaacag ccccgcttcg ttcactatgg 2187121 ccgacagagt gcatatgatc ctcgatcttg aagagaactc ccgcctcctg taaatctttc 2187181 acgagctttt tgcggcattc aaaacgatcc ataccttgat attggagcgc attttcattc 2187241 atcgtgccat cttcattcat gacaaggatg cgttctaaat tgtggcggtt gccaagctcg 2187301 aagtcgttcg gatcatgagc aggcgtaatt ttcacggcac ctgaaccaaa ttccatatca 2187361 acatagtcat caccgacaat cggaatttca cgatttacaa tcggcaggat caccgttttt 2187421 ccgataaggt gtttatagcg ctcgtcttca gggtgaacgg caacagctgt atcaccgagc 2187481 attgtttcag gacgtgtcgt cgcaatttca attgagcctg aaccgtcagc aagcggatag 2187541 ctcatatgat agaatgcgcc ttgaacatcc ttgtaaatca cctcaatgtc ggatagggct 2187601 gtttttgtcg ctgggtccca gttaataata tattcgcctc tgtagatcag gcctttttca 2187661 taaagcttaa cgaatacttc ccttaccgct ttgctcaagc cttcatccag cgtaaaacgt 2187721 tcacgggaat aatctaggcc aagacctaat ttcgcccact ggctgcgaat aaagtcagca 2187781 tattcttcct tccacttcca cgtttcttcg aggaattttt cacggcctaa atcgtagcgg 2187841 gatttgcctt cttcacgaag tttcgcctcc actttagcct gtgtcgcgat gccggcgtgg 2187901 tccatgccag gaagccacag cacatcatag ccctgcatgc gtttcattct tgttacaatg 2187961 tcttgcagcg ttgtgtccca tgcgtggcca aggtgaagtc tccctgttac gtttggcggc 2188021 gggatgacaa cagagtatgg ctcttttgtc tggtcactgc ccgcttcaaa aaatttgcct 2188081 tttagccaaa aatcatatcg gtctttttca accgctgccg gatcatattt cgtcggcatt 2188141 gtttgttcat tcgtttccat cataaccctc cagcatgttt aaaaatggct gagaacgaaa 2188201 aaagagctct tcatccctgt aaaaggacga aaagctcttt cgcggtacca ccttttttca 2188261 tgaactcaat cagttcatgc acttataacg gataacgggt gtttcccgaa tttctctact 2188321 cttctttcaa gaaattatgc tcccgggcga ccttccaatc agacaacata agaagccttt 2188381 cagcaaacgg cttctctctc tgcatgcgcc ttttttgtac tcttcccgtt ctaagcaggt 2188441 gtatttatca gctcattgta tacattattt atgttcttta ttatagtaaa agtgtttttg 2188501 attcgtcaat catcttttcc aaaaacaccg ctttctatac agatgggcag gcacctattg 2188561 cccaagttta catatgatgc ttgtaaatgc gtagaggagg atgcaccgtg aagaaacgtt 2188621 tcagctctta ttcgctgccg ccatgggtaa ggcaaattcg gcttgtatcc gcacaagtga 2188681 ttattcccat tacgattttt caaggaatca gaaccatttt ctttccgaca acctttgatg 2188741 ttttgctgct cgcaatccta atctttttag cttgcgccct tcatttagaa tggatataaa 2188801 caaacaagtc cgcgccatta agacgtggac tcgttttcag cctgaaattt tttctcttgt 2188861 tcaatctgat gaattttcat cacaaacggc tctatgtttt tcatttgcca ataagccttt 2188921 aataattgtg tacattcctc tttttcatgc tgtcttttcc cagtttgata accgttcagc 2188981 accttgtaca tggctgccgg atatgccata tagctgagaa aaaggctgac ttccgcttca 2189041 cgcaaaggga atgatttcgt atatccataa aaccattcga cgcattccgg acaagctttc 2189101 ggaaagcctc tgaacatttt tgtataaaag ccgagcaggt cgttttgcgg cggaccgaca 2189161 gatgctcttt cgaagtttgt aaaatatccg gtcccggcat cattatacag aaaatggtgt 2189221 atagacaggc tgccgtggtt cattacaacc cttgaaacgt ccttttcctt tgcggactca 2189281 taccagtcct ccagccgttc cagcgcaaag ttcaccgcgg aaatggtttc agaaaaatag 2189341 gttatggcct ggagttcaaa gggagaaagg taccattcct tctccgctct atccacaaac 2189401 tgctcataga aaattttatc ttgttcccac ttttttttcg tttgcccgta ataacgttca 2189461 atctcatcac gtctaacctt tagttcctgc gcggttctct cgtgaagacg ggctgtttct 2189521 ctaaataaat aagcatgttt ttgatcccgt tcttcctctt ggtcaaattg gagccaaggc 2189581 attaaatagt agatatctcc gtattgtatg cctgctgaga aaaactcacc gctatttgtt 2189641 ctgtaaacgg gaacgaatga acgaaagcct ttttcctcaa tcgccaccat atgatctgta 2189701 aaatgcttgc cgcgaccttc tttcaatttt ttcagggcaa atatgccgta gtctgtatac 2189761 actttccaaa caagaggact gacaggctca ataaattgag cagtcagtcc gtattcctga 2189821 agaaccgatt gggtatcttc catttcattc accacatttt ccgatcactt acggtttacg 2189881 catggctatt tttatattga ggaatataga gaatctgtcc tgcttttaat tcatcatcca 2189941 aggctaaaga attcatcctg atcagctgct gggatgtaat ttcataccgt tcgcataaac 2190001 gctcgatcgt atcttcctgc tgcacaatac aaattttcat tctcgaaaac tcatccgctt 2190061 cttttgtaaa gagttttgtt aaataaagag aattatcact ttcctttgtt tgaggttcct 2190121 tcgtttcagc agcaggagca accctaggaa cagcatccgt ttccttcctt tcagtctcag 2190181 aagattcagg cagctggaag gattgaaaag gtgtttcttc cttaggctct tcagctgatg 2190241 gtgtttttct cacttcaatt tcgaagctct cttcctcttg ttcttcctcc tccagcagct 2190301 taggcgctga ataaaaagaa tcctcctctt cttgttcagg caggaaggta cggtatgccg 2190361 gttcaggcaa ttcttcttga gatgcctcct ccgagcttgt tttttgattg aaatggaaat 2190421 gtaaatcggc attgtcattc tccatatata cagctgaagc tgtttctctg ctatcttcta 2190481 tggagagagc ggcctctgat acactctcca aagcttcatc cggttccgcc tcttcttggc 2190541 aaagcgcagg atcagcctga tccgattgag ctgcttcttc attttgagcc tcttggcgca 2190601 gcgcatattc atgattagga gacactgttg tttcctcttt ttcctttgca atcacagtct 2190661 ctgaatgaag ctcagcttcc aaagcaggcg attcttctgc tccaacgtgt tcacgaagct 2190721 cagtctccgc tggagagtct gcttcttcac gaacatccgc tattgcagct gccggctctg 2190781 ccgtttcttt ttttgcttta acgatctctt gaatctctat ttctgaagga tcaggttctg 2190841 gctcagattc ttctgtttcc gattcagcac gaacctccgt ttccggcaca gcaagctctt 2190901 ctgactcttc ttcctctttc acatcttctc tggcctctgg ttctgaagca accgattcag 2190961 gcggctcaga ttctgctttt tctgtctcca gttcttcacg gagccccgct ttcgagataa 2191021 aaagttctgg cggttcggct ggcggttcat gctgaagaac tgcttcctct gccgatgatg 2191081 cacccggttc ttctactaca ctatgtgccg gcggctctga aagctcttcc tccctgaatg 2191141 ccgcaggagc ttcatataaa ggtatctccg gctctttgtc ttgcgtatcg tccaaaagcc 2191201 cttcgatcgc taaatcagct tgaattgtta aaatgcgcga atccgtcaat tgatagtcaa 2191261 atgcgtcaat aaagacgaag acatcctgta aatggctcac tttatttttc ggaatggtaa 2191321 tatccacagg aaaacagtga gtcagttccg cacttccatc ctctctcttt ctgacttgtt 2191381 caacaaaccg cttatctgta taaatctctt cggtatgttt gttttgatct atgttgtact 2191441 cacctgtaag ttcaagcgat cctatgattg atacataatc atttacttcc tgaaccctaa 2191501 tatcaggatc taatgaaata gaaagcagtt cagaaacttc ctgtcctttt tggaaacaga 2191561 tcgattcttc tacagaaaat tgcaatcgat gattttgcgg caagttcata tcctcctttc 2191621 atctaatcct taaaattaga tgtcactaaa ggtgtatgta tgaactggag aaaatatgag 2191681 tgggagagca cgaaaaaacc ggcacaagga gtccttgata ccggttttca ctcttatctg 2191741 cggctgatct cagcaaatac tttctcagct gcctggattg tgttttcaat atcttcatca 2191801 gtatgggccg ttgagaggaa aagaccttcg aattgtgatg gcggaaggaa taccccttca 2191861 tttgccatcc ctttataata gcttgcgaac agcttcaaat cagatgattt cgctgtttca 2191921 taattgatga ctggttcgtt tgtaaagaag aaaccgatca tcgaacctgc acggttaaag 2191981 gtatgcggaa tgccatgagc cccggcggtt tttgaaattc cttcttccag tctgtcgcct 2192041 tttttgatga aattcttgta ggattcaggt gtcagctgtt tcaatgtctc taagccagcc 2192101 gtcatcgcaa gcgggttgcc tgacaatgta ccagcttgat agatcggacc gcttggagcg 2192161 atctgctcca tgatttctgc ctttccgcca taagcgccga caggaagtcc gcccccgatt 2192221 acttttccta aacaagtcag atcaggcgtt acgccgaagt agccttgagc gcagttataa 2192281 tcgacccgga agccagtcat cacttcatca aaaatcagca gggagccgta ctgctcagtg 2192341 atatcacgca gaccctgaag gaaaccttct tgcggcggaa caacacccat atttccggca 2192401 actggctcta caatgactcc cgcaatgtct tcaccgaatt gctggaaagc aagctttaca 2192461 ctttctaaat cattgtacgg aacggtgatg gtgtttttcg caatgccttc aggcaccccc 2192521 gggctgtcag gcagaccgag agtggcaaca cctgaaccag ctttaatcaa gagagaatcg 2192581 ccgtgtccgt ggtagcagcc ctcaaatttt aaaatcttgt tgcggcccgt atagcccctt 2192641 gccaaacgga gggcactcat tgtagcctct gttccggagc ttaccattcg tacaatttct 2192701 acagatggca cacgatcaat gacgagctta gccagttcat tttctacttc agtcggagca 2192761 ccaaagcttg tcccgtattc agccactttt ttgaggcttt ctacgacgcg gtcatttgta 2192821 tgccctaaaa ttaaaggccc ccatgacaag acgtagtcaa tatattcatt cccgtcaata 2192881 tcaaagattt tcgagccttt tccgcgctcc ataaaaatcg ggtccatgtc taccgattta 2192941 aatgcgcgaa cgggactgtt cacaccgccc ggcatgagtt tttgcgcttc tttaaaagcc 2193001 gtttttgatt tttcatagct tctcatctgc ctcaactcct gtcaactgaa taaaattact 2193061 ccgcaagcca tttcgctgcg tctttcgcat gatacgtaat aatcaggtcg gcacccgcgc 2193121 gcttcatgct tgtcaaaatt tccaacacaa tttctttttc tttgatccag ccgttctgcg 2193181 ctgcagcctt caccattgaa tactctccgc ttacattata agcgacgagc ggcaaagtaa 2193241 actcattttt tacgtcacgc atgatatcca tataagaaag cgaaggtttg acaatcaaaa 2193301 agtccgcgcc ttcctcaaca tctgattgtg cttcgcggag tgcctccata cggttggcag 2193361 ggtccatctg atatgttttg cggtctccga attgcggtgt gctgtttgct gcatcacgga 2193421 acggaccgta aaactcactt gaatatttaa cagcgtaaga catgatggga atattgacga 2193481 atccttcttt atcaagtgct tctctgatca ctgtaacaaa tccgtccatc atgtttgatg 2193541 gcgcaatgat atccgcacct gctttcgctt ggctgacagc tgtctgcgcc aaaagctcca 2193601 gcgattcatc attgagaatg actccgtctt tgacaagtcc gcaatggccg tggtctgtat 2193661 attcgcacag gcacgtgtca gcgacaacaa ccatttcagg gaagtgttct ttaatttctg 2193721 tgatggcttt ttggacaatt ccgtgatcat ggtacgcttg tgttccgcaa tcatcttttt 2193781 cttccgggat gccgaacacg ataacagatt gaatgcccag tttgaccagc tccgctactt 2193841 catccttcaa taaatctaat gatacatggt gaacatcagg cattgacgga acagcttttt 2193901 tgccttccag cccttcaacg acaaaaatcg gatatataaa atctgatgga tgcaaacgtg 2193961 tttcctttac catttctctc attgcttttg atgtccgcag gcggcggtgt ctattaaatg 2194021 attgactcat attctctctt cctctcttga catgctgcac attaactcaa gcatgccatc 2194081 tattgtaaat gtatcaggcg tatgcgatgt gatgccgtac gtcagaaggg catcatttgt 2194141 taaaggccca atgctgatac aggccgtccc attcgccttc cactttttta attcttctcc 2194201 caagacatgc ataaacgtat gtacggttga tgaactcgta aatgttacat agtcaaagga 2194261 atattgaccc gcagcgtctt tcaatgcctc aatgccttct tcatccggaa tcgtttcgta 2194321 gagaacccat tcctttactt caaaaccgag cgggacaagc tcttgtttta tcacatcacg 2194381 tgacaaattc cctttcatca cggtaatggt ctcccccggt tcagcatgct gcttaagagc 2194441 gtcagccaat tgttcagcaa tatactcctg tggcatcaca tcaaccgata cgttatgcat 2194501 ttttaaacgg cgcgcggttt tttcaccgac ggctgcaatt tttttatgcg cagggagaat 2194561 aagctgattt tccttcagat aagaaaaaaa gaagtctgcc ccgttcacac ttgtaaaaac 2194621 aagccagcct ggcgcggcaa gatcctctct tacctgttcc gcaacatcat tcggcaaagc 2194681 gcggcgaaac gtaatcaaag aggttaaaac cgctttaccg ccaagcgcct ccactttttg 2194741 ctgaaatgat gctgcctgtg ccttattccg ggtgacaagc actgtttttc ctttcaacgg 2194801 aaaatcattt tccatcctcg tcaagctccc gttttacacg atcaattaaa tcttttgctc 2194861 ctttgtcagc cataagagcg gcacagcgct ttcctacttc ctccggatcg tttccggtga 2194921 cggtttcttt aaaaatgatt ttgccgtcag gtgaagcgac aagacctgtc atttcaattt 2194981 catcctgtcc atttaacacg gagtagcccg cgatcggaac ctggcagccg ccctccatcg 2195041 cgtttaaaaa agcacgttcc gctaagacag tccgttttgt atattcatct gtaaactgag 2195101 aaaacaacgc caacagctct tcatccgatt ctcggcactc aatcgccagg gctccctgcc 2195161 ccacagcagg caaacagcgc tcaggctcaa ggaattcggt tacgacatct tgcttccaac 2195221 ccattctgga aaggccggca gccgctaaaa taattgcgtc ataatcctct gtttccagct 2195281 tttgaagtct tgtatctata ttacctctaa tccatttaat tgtaaggtca gggcgctcaa 2195341 tcaaaagctg cgcgcttctt cttaaactgc ttgtgccaat gacagcacct ttcttcattt 2195401 ctgaaagctt tacgcgattc tttgaaataa gggcatcacg cgggtcctcc cgttcaggaa 2195461 tacagccgat cacaaggcct tcaggcaaaa cagcaggcat gtccttcatg ctgtgcactg 2195521 ccatatcaat ctcttcgttt aaaagcgcct gttcaatttc tttgacaaaa agcccttttc 2195581 cacccacttt tgagagtgta acatcgacaa tccggtcgcc ctttgtcacg atctctttaa 2195641 tttcaaaagc aaacgaagga ttgatttcct tcagtttttg aataacccat tttgtttgag 2195701 tcatagcgag tttgctccgt ctggaaccta ctttaatcgt tctcatcatt tctttcctcc 2195761 cgaatctgct tgggacatcg tttaactgaa ccaatggaat tgcgacaggc ttccaagcag 2195821 gaaataattg atcatcagca ccagaaaaca agccgtattc cacagtgcag cgacctttcc 2195881 ttgcagctcc ttaatcagcc tgatataaag ataatagctg tacagcagca ggacgacaaa 2195941 cgaaccaagc actttggcgt caaaccaata cagcgtttct agtgagacat acgcccaaat 2196001 gacgccgaga atcaaactca gcagcagcat cggaacccca atgacattta aaacatacgc 2196061 catataatca agcttagata aatcttctat tctcaacagc cattttcccc actttttctt 2196121 tttcagcaga tgatattgaa acatatatag cacagaaaaa acgaaagaaa gggaaaaagc 2196181 gccgtatgaa agaatcgcca ttgtaatatg aatcaccaaa agctcggata caagctgccc 2196241 ggaaaaagca gctgactgct gctctgtcgg tgaaaatgtg tgaatggcga tcatagaaaa 2196301 tcctataaca tttgtaaaaa acacgataaa gtcaacacgt aaaagctttg tcagtacaag 2196361 tgacagcgtg acaagcaccc aggcataaaa ataaagtgcc tctgtcacat ttaataccgg 2196421 aaaccgcccc gtcacccaca taaaataggc caaatacacg gtttgcagag tccagacaat 2196481 agaaagcaac cagaaggcca tttttccagc cttccggttg tgttgaagaa aatctataaa 2196541 ataaaagagt acacttaacg cgtaaatgac gattgtcccc tcattaagtc ttgccattgc 2196601 agtatcaatc attcagcttt cactcactta caagtgggct aaagcccgct tttgattcag 2196661 ccttcttaaa agagtggacc ttctggctgc tttcaacggt tttcatcatt tgacggcccg 2196721 cagcttcttc aatatcaaaa atctgcataa acaacgcgag cttttcttca gaatcagcat 2196781 ctgccgcaag ctctttcacc tttaaaatcg gatcacgaag catttggtta ataatacttt 2196841 tggtgtgttt gttcaacagt tttttctctc ttgtgcttaa gtgaggcagc ttacgctcaa 2196901 tgctgtccat cgtttctgac tggatggcaa gcgccttttc gcgcaatgca gaaataacag 2196961 gcacaacacc aagtgtattc atccattgtt taaattccac aatggtttct tcaattaaca 2197021 gttcaacttt ttcagctgtt tctctccgct ctttcatgtt cgcttctaca atgccttcca 2197081 gatcgtcgat atcataaaga aaaacacctt caagatcatt cagcgccgga tcaagatctc 2197141 taggcacggc aatgtcgacc ataaacagcg gacgtccctt gcgaagctta ttcgcgtttt 2197201 ccatcatctc tttggacacg acaaattcac ttgcaccggt tgaactgatt aaaatatcag 2197261 cctccgcaag cgcgctttca agctgattca agcttctcgc ttcacctgaa aaacggtctg 2197321 caagctcctt cgctttcaag tatgttcggt taatgacagt gaccttgccg attccctgtc 2197381 cgtgcaggtt ttccgcagca agctcgccca tttttcccgc accgagaatc aatatgtgct 2197441 tgcttgaaag atttccgaag atttttttgg caagttcaac tgcagcatag cttactgaca 2197501 ccgcatttga gccaatgtct gtttcggcgt gagtccgttt gcccactgta actgcctgct 2197561 taaacagctc attaaaaata gtcccgatcg ttttttcttg ctgagctgtt ttaaagctgt 2197621 cgcgtacctg tccgagaatc tgcgtttcgc caatcaccat agaatcaagt ccgcaggcta 2197681 cacggaataa atgctcaaca gcggcatcgc tctcataaaa cgttaagaac ggtgacagct 2197741 cttctttgct taattgaaac caatcagcta aaaacttttt tatataataa cggccggtat 2197801 gaagctggtc gactaccgca taaatttcag tgcggttgca ggttgagaca atgatgtttt 2197861 caagaatgct tttctcttct ttcagctgca ccattgcttc tgccagctca ttcggctgaa 2197921 aacttacttt ttcacgtatc tcaatagggg cggatttata atctactccc acaacaagta 2197981 tatgcatcgc tctaattaca cccccaacac ccaatcttaa tttataatca ttctaacata 2198041 gaactcatta tttataataa ttataacata gtttctttca caaaatgtga acagatttta 2198101 aaattcttat gctatattag aaaaagcttc agggaaaaga agcattccta ttgacaatac 2198161 caaaaacagc agaaatttac tacacatcag ctctaaaaaa caagaaggtg atatgcatga 2198221 aacaaaaatc aattttattc ccttgtctgc tgcttgccgc ttctgtatat gcatggctag 2198281 aaagcggcca agccgaactg ttttcagggc aggatcaatg gcctgttctc ctcatgctgt 2198341 taggcgcagc ctttgtatat caaggaaaaa aagaagccgt cacaccccat ttttttatcg 2198401 gtttgcttct cttcgggatc ggtttacact tttttgccaa gccgaaatgg gtatggtggc 2198461 cggatgattt tgaaatgctc ctctttatga tcggcttctc acttctcgtt tcaaccgttc 2198521 aaaaaaaaga atatgtatat gaagctgtgt cgatgatttg tttttccctg tttttgtact 2198581 ttttcaaaca aattatggca tggcttgagt ctgcgcatat tccaacagcg cttctgaagg 2198641 agtattggcc gtttgtcttt attggaatca gtttattgtt attattgata aaacgaaaaa 2198701 aatctatacg ataaataaaa ccggtagagg atcctctacc ggtttatcat ttttttgatc 2198761 gctccccaag cttcgtcttt tccctttttc gtttctgaag aaaagaggat cagctcgtct 2198821 tccggatcaa tatttaatgt ttgtcggaca accttcgcgt gtttgtccca tttacctttc 2198881 gggatcttat ccgcctttgt agcgataaca ataacaggaa tgccgtaata ctttaaaaat 2198941 tcatacatct gtacatcatc attagatggc gcatgccgca aatcaacgat ctgcaccaca 2199001 gcttttaatt cctcgcgtgt cgtgatatag gtttcaatca ttctgcccca tgcttcacgc 2199061 tcagactttg acactttggc aaaaccgtag cccggcacat ccacaaaatg cagctcatca 2199121 ttgataatgt agaaattaag cgtttgtgtt tttcccggct ttgatgacgt tctcgcaaga 2199181 tttttgcgat tgattaatga attgataaaa gacgattttc ctacgttcga tcttccggcc 2199241 aatgcgattt ccggaagccc cccttcaggg tactgttccg gttttactgc actgatcacg 2199301 atttctgact ttgtgacttt catttcttct ctcctactaa ggcatgttcc aaaacctcgt 2199361 ctaagtggga cgccaatata aatgtcagcc cctccctgac gctttccgga atatcctcta 2199421 tatctttttc attatcttta ggcgcaataa tggtcgttaa tcccgctcta tgtgcgccaa 2199481 gcgctttttc ctttaagccg ccgatcggca gcacgcgccc gcgaagcgtg atttccccag 2199541 tcatgccgac ttcacgcgaa accgcccgtc ccgttaaagc agaaacaagc gctgttgcca 2199601 tcgtaatacc ggctgacgga ccatcttttg gcaccgcacc ctctggtaca tgtatatgaa 2199661 tatcatactt ctcatgaaag tcaggttcaa tgccaagttc ttctgttttg gatcgcacat 2199721 agctgaatgc agcctgagca gactctctca taacatctcc gagctttcct gtcaggatta 2199781 atttcccttt tcccggtgaa agcgatactt caatcgaaag cgtatctccg ccaacggttg 2199841 tatacgcaag ccctgtcact acaccaactt gatcctctgt ttcagcttgt ccatatctga 2199901 aaatgcgttt tccgataaaa tcttgaaggt tcttctcagt aaccgtaatt cgttttcgct 2199961 cttcagcaac aatggctttt gcagctttac ggcaaattgc ggcaagctgg cgttcaaggc 2200021 ttcttacacc cgcttctctc gtatagtaac gaataatatc aagaatcgcc tgatcacgca 2200081 gctgaagatt gcttttcttc agcccgtgtt ctttgatttg ctttggaagc aagtgatcct 2200141 ttacaatttc aagtttttct atttctgtgt agcctgcgat attaataatt tccattctgt 2200201 ctctgagcgg gcccgggatt gtggccaaat tgttcgccgt tgcgataaac agcactttgg 2200261 ataaatcaaa ggtttcttca atatagtgat cactgaagct gctgttttgc tctggatcaa 2200321 gcacttcaag catagcggat gatgggtctc ctctaaaatc agatgacatt ttgtcaattt 2200381 cgtctaataa gaagaccgga ttcagcttgc ccgctttttt catcccttga ataatacgtc 2200441 caggcattgc tccgacatag gtccgtctgt gtccgcgtat ctctgattca tcccgaactc 2200501 ctccgagtga gattctgacg aatttgcgtc ccaagctttt tgcaattgat ttggctaaag 2200561 acgtttttcc gacacctgga ggtcctgcca aacagagaat cgggcctttc agggattttg 2200621 tcagcttctg gacagccaaa tattctaaaa tacgttcttt tactttttca agcccgtggt 2200681 gctcttcgtc caagagacgt cctgcttctt tcaaatcaag cttatcatct gtttcatccg 2200741 tccacggaag agcaaccagc cagtcgatat agttgcggat cacagagctt tccgcagaac 2200801 ttgacggaat tttttcatat ctgttcaatt ctttaagcgc tgtttctttc acatgatcag 2200861 gcatgcctgc ttcttcgatt ttttccgtca gcgtctgaac ttcgccagtt ttgccttctt 2200921 tatcgccaag ctctttttgg atcgccttca tttgttcacg caagtagtat tccttctgcg 2200981 tacgctccat cgaacgtttg acgcgctggc cgattttttt ctcaatctcc agcacttctt 2201041 tttcattatt aataaaatca atgaccttgt tcagcctgtc tttgacatca gccgtttcta 2201101 aaatatcctg cttatccttt agtttaaggg gcagatgaga agcaacgatg tctgccattc 2201161 tccccggctc ttcgatatca gtaaccgcag cgtacgtttc ggccgagatt tttttagaaa 2201221 tttttatgta ctgatcaaag tggtctagca aagtccgcat caatgcttcg tcttctgtat 2201281 cttttgaatc atcttcatga ataagttgaa tgtcaaccga cgtgtaatcc tcgtgttcat 2201341 tgtatttgac gatatgggcg cgcttgaggc cctccaccaa cacacgaatc gtaccgttcg 2201401 gaagcttcag catttgctta atttttgtat aggtgccgac agtgaaaatc tcgtcttcac 2201461 caggttcgtc tatcgaaata tcctgctgag tggctaaaaa tatcatatga tcatgcatca 2201521 ttgcctgttc aagagcctga accgacttgt cacgtcctac atctaaatgc aaaaccatcg 2201581 tcgggtacac taataaacct cttaaaggga ggagcgggat gctgcgtttt aattcttctg 2201641 ccatgtgact gacacctccg tgactttagt atgaaccatt ataatacaac tttttcatcc 2201701 ttgtacaata aacggcatgg ttccattttc tataaaacag tctcctcgta gtataccctt 2201761 tctttctgat atgaaaaagg aaaagatgtc cttcatgaaa aaaaccctat tatcaaaata 2201821 gggtttaaac ggattcttta ttgatttcga tatgaaacgg tttttgttcc gttggcggat 2201881 tcaccaaaat ttcatcaagc acttcttgga acgtcttcac tgcaataatc tcgatcccgt 2201941 caatctgctt taagatggcc tgctgatttt catatgggat aatcaccttt ttcgcaccgg 2202001 actgcttggc cgcttttatt ttcggaatga cgcctccgat gggtttcaca agaccgttca 2202061 ggctgatttc gcccgtcatc gcaacggtat tgtcaatagg aattttgtgt atcgccgaga 2202121 aaatccccgc cgccatcgca atgcctgctg acggcccatc aatcggaatc cctcctggga 2202181 aattgatgtg aatatcataa tcagaaggct tcattcccat tgtccggagc acggttaata 2202241 cattttcaac cgaacccttc gccatgcttt ttcgcctgat cgattttgat tggctgccga 2202301 tgctttcttc ttcagctatt cctgtgatgt taattgatcc tttatcttga gccgcggtta 2202361 cacttacttc gatttccaga agcgatccgc tgttaggccc atagactgca agcccattta 2202421 caatgccaac ctgtggttca acaccgattt tttgctcgtg ctttggagta agctgactgg 2202481 agtgaatgac ccattcaata tcctcaatcg taatgtcctt tcgattctcc gttacagcca 2202541 tccccgctgc gatttgaatc atattgacgg cttcccgccc gttccgcgtg tagctggtca 2202601 aaagatccag tccttcttcg gagatatttt tttcaatttt atccgctgct gttttggcaa 2202661 ccgttttcag ctcgtccttt tcaagctcgc ggaaaaaaac ctccaaacag cgggaccgga 2202721 tagctggcgg aatttcgttt ggcattctcg tggtcgcgcc aatcaagcga aaatcagccg 2202781 gcagcccatt ttgaaaaata tcatgaatat gattcggaat ttgtgtattt tcctcactgt 2202841 aatacgcact gtctaaaaag acttttctgt cctcaagcac cttcagcatt ttattcattt 2202901 gaataggatg cagctcccct atttcatcaa taaacagcac accgccatgg gcatgggtga 2202961 cagctccctg cttcggctgc ggaatcccag cctgtcccat cgctccggcc ccttggtata 2203021 tcgggtcatg gacagagccg atgagcggat cggcaattcc tctttcatca aaacgggctg 2203081 ttgtcgcatc gagttccaca aagacagcct gctctttaaa cggtgattgt ttatgttttt 2203141 ttgcttcttc caacacaagc cgcgcagcag ccgttttccc aactcccggt ggcccataga 2203201 caatcacatg ctgaggattt ggcccgcata aagccgcctt taatgcttta atgccgtctt 2203261 cctgtccgac gatatcttta aagcttttgg ggcggacctt ctcagataat ggctcggaca 2203321 agctgatagc gcgcattttc cgaagctgct ccatttcctt ctttgattct ttatctatcg 2203381 tgaccttttg tgtcctttga tttttaagca aattccaaaa atacaaaccg atgatgatcc 2203441 caaaaaacag ctgaataaat aacgcgatcc ctgtccaact catggtggtc cctcctgaaa 2203501 aacaatttat gtatccaatt cattcctctg attgctagta tctcccatag aagacgggaa 2203561 taaacgtttt tccggaagag ttgcatgcaa aaaaacctcc tgagtgttac cactcaggag 2203621 gtttgtgctt atctttatgc agatgtttta tcttggctta cctcagtgcc gtcttttaat 2203681 aagaggcgag gaggctctcc gtgtgtcaca gttgccccgg tgattacaca tttttcaatg 2203741 tcatcacgag aaggcagctc aaacatcaca tcaagcatga tgccttcaat gatagaacgg 2203801 agtccgcgtg ctccagtctt gcgttcaatt gcttttttag caatttcaga aagcgcttct 2203861 tcttcaaact caagctcaac gttgtcaagc tcaagcattt tcttgaattg cttaacaaga 2203921 gcgtttttcg gttttgttaa gatcgcaacc aatgcttctt cgtcaagctt ttcaaggctt 2203981 gcaataaccg gaagacgtcc gataaattca ggaattaacc cgaaacggag caaatcttct 2204041 ggaagcactt ttgaaagaag atcttctttc tcaagatcag cagctttatt gtcggcaccg 2204101 aatccaatca ctttttggcc taaacggcgt ttgatgattt gttcgatacc atcgaaagct 2204161 ccgccgcaaa tgaacaaaat atttgttgtg tcaatttgaa tgaattcttg atgaggatgc 2204221 ttacgtccac cttgaggcgg tacgcttgcc actgtaccct caagaatttt aagcaatgcc 2204281 tgctgtacac cctcacctga cacatcacgt gtgatagacg ggttttcaga ttttctagcc 2204341 actttatcga tttcatcaat atagataatg cctttttcgg ctttttccac atcataatca 2204401 gcagcttgga tgagcttcaa gagaatattc tctacatctt cacccacgta tccagcttca 2204461 gtcaaagatg tagcgtccgc aatcgcaaac ggcacattta aaatgcgagc caatgtttgc 2204521 gccagaaggg ttttaccgct tcccgtaggg ccgattaatg aaatattact ttttgaaagc 2204581 tcaacatcat caactttgct gttggagtta atgcgcttat agtggttata cacagcaaca 2204641 gcaagtgatt tcttcgcttg atcttggccg atgacatatt cattcaaaat ttcgcgaatt 2204701 tcctgaggct ttggtacgtc tttaaattct acttcttctt ctgttccgag ttcttcctct 2204761 acaatttcag tgcagagttc gatacattcg tcacatatat atacaccagg tccagctaca 2204821 agcttacgaa cctgatcttg tgtttttcca cagaacgagc attttaattg tcctttttcc 2204881 tcgttaaatt taaacattct ttcacccctt aatcttgtct cactttttct tttaccggca 2204941 gagcaaaaga aaatgattct tgaaacgaac gagtatgtat tgcattttac catactttcc 2205001 aaaaagacgg taacaatgtg tttctgactt gcacattcta tatgtatgac aaaaaacagc 2205061 cctgcattaa ctatattgcc ccaagaaaaa gagataactc ataattgtac aaaacaaggc 2205121 acgaatgatt cgcgccctgt tttattagta ctattattat gcaccatatt aacggttttc 2205181 tacaagaaaa tcaattgctt tgcgaacttt taaatcttct ttcatcgcgt cagtagaacc 2205241 gatggcttgt ttaatatttt caacaggcat gttgtatgct tcagccattt ttgtaagctc 2205301 agcatcaact tcctcatctg atacttcaag gttttccgct ttcgcaatcg cctcaagagt 2205361 caggttagat tttacgcgtt tttcagcatc ttctttcatt tgctctttaa gcgcagcttc 2205421 atcttggcct gagaattgag tgtaaagctc aaggttcatg ccttgcattt gcagacgctg 2205481 ttcgaattct ttcagcatgc ggtcaagctc agtgtcgacc attgcttgag gcacatcgat 2205541 ttcagcattt tcagaagctt tcagaacaag ctcttcacgc aatttagcgt cagcttcgtt 2205601 ttcttttgct tcttctaaac gtttctttgt tttttcagtt aattcagcaa gtgtttccac 2205661 ttcttcatcg atatcttttg cgaattcatc gtcaagctca ggaagctctt tcgctttgat 2205721 ttcgtgaatt ttcactttaa acacagctgg tttgcctgca agatcttcag cgtggtactc 2205781 ctcagggaat gtcacttcaa catccttctc agcacctgct tcaaggccaa ctaattgatc 2205841 ttcgaagcca gggatgaatg aaccagaacc tacttctaga gagtagtttt cagcttttcc 2205901 gccttcgaaa gcttcgccgt caacgaatcc ttcgaaatca agaacaactg tgtttccttc 2205961 ttcaacggcg ccttcttctt ttacaacaag ctcagcttga cgctcttgaa gggcttttag 2206021 ttcgttttga acatcttcgt cagttacagt tgtgtcgtct ttttcaatgc ccaggccttt 2206081 gtattcgcca agcttcactt caggttttac tgttactttc gcagtgaaga ttaagctttc 2206141 gcctttttcg attttttcaa catcgatttc aggacggtct acaggctcga ttccagcttc 2206201 ttcaaccgct ttagggtatt ctacaggaag aagaatatcc aaagcatctt ggtaaagagc 2206261 ttctacgcca aagcgctgtt cgaataatcc gcgaggaatt ttacctttac ggaatccagg 2206321 aattgaaact tgttttacta cttttttaaa tgcatcatca agtgctgttt taaacgtttc 2206381 agcatcaact tcaaccgtta aaacgccttc gttgccttct tgtttttccc attttacaga 2206441 catgtgtttc cctccaaaaa tctattcagg ttgtgtcggt cttccattct aaagcaatca 2206501 ttcggcttcg tccaacaaaa acaaagctgc caaagatcag aatcattatg tatagatgtt 2206561 aataatgaac tgcaaagcct gtccaaccgt atttcttata acccgttata cacaaataca 2206621 accactatat tataacataa cacatagcgc tttcaactat atggcgcgat ttacaaataa 2206681 gaaatttctt caatatcttt taacattgtg caagcttcat cgagttctct gtctgtaaat 2206741 tcatacatca tatgaagttc ttcgctttca atttcaatcc cgtgcatctc gtaaccgact 2206801 ttatgaaggg cagccgccca aaggtcagcc gacagcaatt tcggctggaa cggatataaa 2206861 acgtacaaat gtcttctcca caattcttct actgctgcat ataaggttgg attttcattt 2206921 ccaagtgtct catctagcac cctgagaaca cggtgaagaa tcggcgcggc atcaggcgga 2206981 acaatctctg acggttcaat tgtcaacgac tcgccaaatt tactaatgtg tacaggttta 2207041 ctgtactcat gctcagccaa cagcatgaca atcatcgttt tgataatcgg atgggctgag 2207101 gggtcttgga ggattgtttt gagcaatcct gtatactttg ctacgttacg gtcttttaag 2207161 gaatgaatga gattcatttg ctcctcaggg cttgccagca ctttctcggt gtcaattgta 2207221 tcctcatatt cttcggccca agcctcgtcc tcacgatccg gatcggtcat tttccggctg 2207281 aaatccagca gcttataaaa ttgctcggca ctttctgccg gcagctgatt ttcttccaaa 2207341 acggcttcaa tggtgctttt gacttcttcg tactttttga gctgaattaa gatggtcatg 2207401 tacacctgca aaaccgtaaa ataatggcca taaccttctt tgagcatctt ctcgcacacg 2207461 ctttctgcct cttccagctc gcccagctct aaaaagcaga tggccatccc taagtgaaga 2207521 tcggattcag tatcatcata tttcatcgct tctgaaaaca gttcaagcgc ttcttgatac 2207581 tttttttcct tgagtgatga catccctttt tccacaaggc ggtctttcag atgaggaaaa 2207641 ggaataattt ttgcgttttt cttgtcatgc gtcataccta tattcctttc aggcatttat 2207701 tttgttcaag tgtatcaaca cctgtgaaca aaaacaagaa atgaaaggtt tcaccaggca 2207761 aaaaaagccg ccggacaaat accggccgct ttttcaggct tgaagccaag agcttctttg 2207821 tgattcaaat tgcttgattt catcttccag cagcagcgtt aatgaaattt catcatatcc 2207881 gttgatcagc atctctttcc aatgcggatc aacttcaaat gaaatttgat tgccttcact 2207941 gtcatgaatc agctgatttt caaggtcaac agtcatttgc aatgactggt tttcatactg 2208001 gccgacaagc tgtttccaat tgtcatatgg catgcggatc ggaagcatgc cgtttttaaa 2208061 gcagttctga tggaaaatat cagcgaatga cggcgcaatg ataattttaa acccataatc 2208121 atcaagtgcc cacggagcgt gttcacgcga tgacccgcag ccgaagtttt ctcctgctat 2208181 taaaatggaa gctccttgat aaacaggctg gtttaattca aattcagggt tcggttcacc 2208241 attcgcatca tatctccagt caaagaatgc aaaacgtccg tagcctgttc tttcaatcct 2208301 cttcaaaaat tgcttaggaa taatctggtc tgtatccaca ttgatccgat ttaatacggc 2208361 tgctttcccc gtatgtgatt tcaaaggttc catctcgcgc actccttaca caactgtttt 2208421 ttcctgataa aactttctga catcaacgaa gtgtccgtga atggcagcca tcgcagccat 2208481 tgccgggctg acgagatgtg ttcttgcacc ttttccttgt ctgccctcga agttgcggtt 2208541 agaggttgat gcacagcgct ctccctcagg aacaacatca ttattcatac tcaaacacat 2208601 gctgcagcct gactctctcc attcaaatcc agcttccaag aaaatctggt caagcccttc 2208661 tttttcagcc tgaagcttca cgctttggga tccgggcacg acgatggccc ttacgctgtc 2208721 agctaccttc ttccctttga tcatgtcagc agcctgtcga aggtcagtca tgcgggaatt 2208781 tgtgcaggaa ccgataaata cgtgctccac tttaatgtct tcaatttttt ggtgaggagt 2208841 caatcccata tattcataag cacgaatcgc ttctttttta tcgtcttctg cagaaaagct 2208901 ttccggcgca ggaacttcag aatcgacagg aagaaccatt cccgggttaa tgccccatgt 2208961 caccataggg gaaattttgt tgccgtcaag gacgatagat ttatcgtaaa cagcgcccgg 2209021 gtctgtgcgc agcgccttcc attcctctac ggccttgtca aattcttcgc cttttggcgt 2209081 gtacttgcga tttttgcaat attcaaacgt cacctcgtca ggtgcaatca aacctgctct 2209141 tgctcctgct tcaattgaca tgttacaaac agtcattcgt tcatccatcg tcatatttct 2209201 gaatacttcc ccagtgtatt caatgacgta gcctgtgccg aatttcacac cgtatttgcc 2209261 gatgacagca aggatgacat cctttgccgt tacccctttt tgaagcgttc catctacgcg 2209321 cacttcaagt gtttttggac gctgctgcca aagtgtctgt gtggaaagga catgttcaac 2209381 ttcactcgtc ccgattccaa atgcaagagc gccgaaagcg ccatgtgttg atgtatgact 2209441 gtcaccgcac acaatcgttt tccctggaag cgttaagcct agttcaggtc cgacgacatg 2209501 gacaatccct tgatccacac tgtgaagatc ggcaaggcgc acgccaaatt cctcacagtt 2209561 tctttcaagc gccgttacct ggcgtttcgc aacttcatcc tttatctcaa aacgattgac 2209621 agtcgggatg ttgtggtcca ttgtcgcaaa tgtgttttgg ggtcttctga cctttcttcc 2209681 cttttgtctc aagccttcaa atgcctgagg agacgtcacc tcatgaatga ggtgcaaatc 2209741 aatatagaga agatccggct ttccctcacc atgttttaca atatgctgat cccaaatctt 2209801 ttcgatgatt gttcgaggca tcatctttta tttcctccct ctacctagag ctaagaccgc 2209861 ttaacgtaag ctgtcacaca ttagaaattg tattttcact catgattgct gccttaactt 2209921 cctctgtaat ggcctgagtg ctgctgaact cttcactccg tgccaagtct cttgttcttt 2209981 ttccagaagc caagactttg tttaccgcat cttctacagc tttcgcttcc tcttcaagcc 2210041 cgaaagatgt tctcaaaagc attgccgctg acaatatggc tgcgaacgga tttgccatcc 2210101 ctttaccggc aatatcaggc gcggagccat gaacaggttc aaacagatga aggccagagc 2210161 ttgataggct ggctgacggg agcattccga gcgagcctgt aagcatggac gcttcatcgc 2210221 ttaaaatatc accgaacata ttttcagtca ccacgacatc aaattgattc ggtgcataaa 2210281 ttagctgcat ggccgcgtta tccacaagca tgtgctcaag cttcacatca ggaaattctt 2210341 gtgcaacgtc ctcagccact tcacgccaca gccggcttga ttcaagaaca ttcgctttat 2210401 ctacagaggt cactttgcct tttctggctg ccgccatttt gaagccctct ctgatcactc 2210461 gttcaatttc cgttcgctta taaaacagtg tatctactgc ttcctgctca ccttcagtgt 2210521 ttacataacg tttgctcggc tggccgaaat acaagccgcc tgtgagctca cgaacgataa 2210581 cgaaatcaac attatctata tattcttttt tcaaaggcga agcgtcagaa aggctttcaa 2210641 ataccttcac aggccgcaaa ttcgcaaaca aatcaagctg ttttctgatg ctgagcagcc 2210701 ctttttccgg tctcagttcc gaaggatttt gatcccattt cggtccgccg acagcaccaa 2210761 gcaatatcgc gtctgcattt ttacaagcag caacggtttc ctccgggagg gggttatgat 2210821 gttcatcaat agccgcccct ccaatcaggc catattcaaa ttcaaattca tggttaaagc 2210881 gttcggcaac acttttcagt acgtctgtcg ctgattctaa tacttcaggg ccgatcccgt 2210941 ctccgggcaa tagagcaata cgtttcttca agttaaccgt tctcctttct tttatgatcc 2211001 gacagctgtg tggtttttca atccgctcat attcgactgg aaaaccaatt gacggtttac 2211061 tgcgttcaaa taggctttcg ctgatgcttc taatacgtct tgcgctatgc cccgccctgc 2211121 tgattctttt ccgttcacca aaactcttac atacacctgg gcaaatgcat cttcgccttt 2211181 tctattagac tgaatgcggt agtctaagag ctccacatcc ttatcgatgc agcgctcaag 2211241 cgtattgtag attgcttcca cgcttccagc tccagttgca gcttcctgaa taagctgtgc 2211301 gttttcttga tttttcaaag atagagtagc cgtagggacc tgacttgttc cgtaatgtac 2211361 ttgcagagaa agaaattcat acccaatctt gcgatctgtt actttttctt ctaaaataag 2211421 agaaacaaga tcctcatcag tgatttcttt tttcttctca gtcaactctt tgaacatcgt 2211481 aaagaattta ttaatctctt cactgtcaaa ttggaatcct aaagcagtca gccggtcttt 2211541 aaatgcgtgg cgtccggaat gtttacctag gacaagcgca tctgcggtta cgccgacaag 2211601 ctccggtgaa ataatttcat aagtcgattt ttcctttaaa aagccgtcct gatggatgcc 2211661 tgattcatga gcaaatgcat tatctccaac aaccgctttg ttgcgcggga cagccatgcc 2211721 tgtcagtttg cttactaaat cacttgttct cttaatctcg ttcagcgtaa tacctgtttc 2211781 gacttggtag aaatcttttc tggtatggag ggctacggca atttcctcta atgccgcgtt 2211841 tccggctctt tcaccgatcc cgttcacagc gcattcgatt tgatcagcgc cattttcaat 2211901 cgcagcaaga gagtttgcga ctgccattcc caaatcatca tgacagtggg ctgaaagctt 2211961 tgctttgtga atgttcggaa cgttttcttt catatattta aagatatttc cgtattccgc 2212021 cggggccagg tagccgacag tgtccggaag attgataaca ctggcgcctg cgtcaatcac 2212081 tttctcgacg atttctgcta gaaacggcag ttcagtgcgg caggcatctt cagctgacca 2212141 ttgcacaatc ggaaaacgtt cttttgcgta tttcaccatt ccaactgctc tttcaatgac 2212201 ttgttcacgt gtcattttca gcttgtgctt caaatgaatg tccgatgtcg cgataaatac 2212261 atgaattctt ggttgagcgc catcctttaa cgcttcccaa gcagcatcaa tatcaccttt 2212321 tacacaacgg gccagaccag ttactgaaca atttttaatg gttcttgcga tttcctgaac 2212381 agctaaaaag tcacctcggg acgaagcggg aaatcccgct tcaatgatgt ctgccccgag 2212441 tctttcgagc tgcttagcta tggcaagttt ctcctgtgta ttcaagttca ctccagggga 2212501 ctgttcacca tcacgaagcg tcgtatcgaa aaaattaatt ttgcgcaacg gagaccaccg 2212561 cttccttctt cttgccttgt ttcacaaacg gcatcatttc acgaagcttt cttcccacta 2212621 cttcgatttg atgttcgttc tcgcttgcat tgatagcgtt gaaacgagga cggtttactt 2212681 ggttttcgac gatccactct tttgcgaatg taccgttttg gatatctttt aatacttctt 2212741 tcatagattc ttttactttg gcgtccacaa cgcgagggcc tgatacgaaa tctccccact 2212801 gtgctgtgtc agagattgaa tatctcattc ctgcaagtcc ttcttcgtac ataaggtcta 2212861 cgattaattt cagctcatga agacactcga agtatgcaag ttcaggctga taacctgctt 2212921 cagttaaggt ttcaaatccg gctttgacaa gcgcgcttaa tccgccgcaa agaactgctt 2212981 gctcaccgaa caaatctgtt tctgtttctt ctttaaatgt cgtttctaat acgcccgctc 2213041 ttgcgccgcc gattccttta gcataagcga gggctttgtc tcttgcttct ccagtcacat 2213101 cttgatagat tgcgaacaat gcaggtacgc cagctccttg ctcatatgtt cttcttacca 2213161 agtgtcccgg gcctttaggg gccactaaga atacatctac atccgccgga ggaacaattt 2213221 gatggaaatg cacgttaaat ccatgagcga atactaatga ttttcctgct gtcaattcat 2213281 ctttgatttc agcttcgtat actttttgct gctgctcatc cggaagcaga accatgatga 2213341 tttcggcttg ggctgccgct tcttttactg aaaatacttt atgtccgtct tcttgggctt 2213401 gagtgaaaga ttttccttgt ctaacaccga cgatcacgtc tactccgctt tctttaaggt 2213461 tcagggcatg tgcgtggcct tgcgaaccgt acccgataac cgctactgtt tttccagcca 2213521 atacgttctc tttgatatca ccgttataat atacttttac catttcaatc tctcccttgt 2213581 tatgttttat acaatagata ttgttttatt ggatgacgcc ttttgctggg ttcccctcgc 2213641 aaaagccgtt gtacctgttc tcgcgatttc tttaatgcca taaggtttta ataactcaat 2213701 aagcgcttca attttgttag attcacctgt cacctgaaca acgatgctgt ctctgctgac 2213761 atcaacgaca gaggctctaa acggttctat gattccatta atctctgttc ttgttgaagg 2213821 tgcggagaca accttgatta aggccagctc cctctggaca atcgattgat ttgtgatgtc 2213881 tgtgactttc agcacatcaa tctgtttgtt gagctgtttc gttaactgtt caacatcatt 2213941 ttcaccttca acatgaacga cgaaggtgat tctggaaacg ccggctgttt ctgtgtgtcc 2214001 aactgtaatg ctttcaatgt tgtaatgcct ttttgtgaat agaccggtga tccggtttaa 2214061 caccccggag cggttcacca cagtcaatgt gataattctt ttcaaggttt cacccccacc 2214121 atttcatgca gccctttccc cggagccacc atcgggaata ctttttcttc gctggcaacc 2214181 cgcacgtcaa tgacaacagg ttctcttgat gttaatgcct cttccagctt ttcctttgct 2214241 tccgcttctg atgaaattct gatgccttta atgccgtatg cttcggacaa tttgacgaag 2214301 tcaggctgag aagcgaattt agattctgaa taacgttctt catagaaaat ttcctgccac 2214361 tgtctgacca ttccgagaca agcgttattt aaaatcacta ccttgaccgg aagatttaat 2214421 tcgcgaataa catcgagttc ttgaagcgtc atttggaatc cgccgtctcc gacaaccgcg 2214481 acaacagtag catctttttc ggccagctgt gcgccgatcg ccgccggaag accgaatccc 2214541 atcgttccaa gtccgcctga cgtgacccat ttatctgctt tttggaacgg ataaaattgc 2214601 gctgaccaca tttgatgctg gcctacatcc gttgcgacaa tggcctctcc ttttgtaaat 2214661 tgatgaatat attcaatcaa tttctgaggt ttaaaacctt cttcttcatt atctacatac 2214721 cagagcggat actcttcttt ccattctgcg agctgttttt tccattcgct tgaatcgctt 2214781 tgtttgccgt cttgtttgat cagctcctgc aggacaattt tgctgtctcc gactacagga 2214841 atctgtgttt tcatgatttt tccgatttca gctggatcaa tatcgatgtg ggctatcttt 2214901 gcgtttctgg caaagtgttt caggtttcct gtgacacggt catcaaaacg ggcgccgata 2214961 ctgattaata gatcacattc atgaagggcc atattggctg tataagtacc gtgcattccc 2215021 gccatcccta ggaaaagcgg atggtcagcc gggaagcctc cgagccccaa aagggtgtgt 2215081 gccacaggga tttgctgctg ttcagcataa ttttttaatt cttctgacgc ttttccgtgc 2215141 agtacgcccg cacccgccag gatcaccggt tttttcgcac tgctcacggc ttccacaagc 2215201 ttgcggatct gcaaataatt cggctctgtt gtcggctggt atcccgggag attcatctca 2215261 tgatcgtagc tgaattctcc ttcaattgtt gctacatctt tcggaatatc aatcaataca 2215321 ggtccgggtc ttccagttgt tgcaatatgg aacgcttctt taatgatgcg cggcagatct 2215381 tccggctggc gaacctggta gctgtgtttt gttactggca tcgtaatccc taaaatgtct 2215441 gcttcctgaa atgcatcgct cccgattaca gaggttgcta cctgccctgt aaagacgact 2215501 aacggcaatg aatcaatcat ggcatcagca aggcctgtaa caaggtttgt cgctcccggc 2215561 cctgacgtgg caatgacgac acccggtttt ccggagaccc ttgcgtatcc ctccgctgca 2215621 tgaattgctc cttgttcgtg acggggaagg atatgtacca accctgaatt gtatagctta 2215681 tcgtaaatcg gaagcacagc cccgcccgga taaccgaaga tcatttctac tttctctttt 2215741 tttaatgatt caatcagcat taatgctccg ctcatcgtct gtgtacattc ggcagatgct 2215801 gaatccacct gtacattagt ccccatttta gttcctcctt ttggattttc atcctttaaa 2215861 gatcatcttt tcattagcta gatagctgat tattcaataa aaaaagccct tccgcccaca 2215921 atcagccgcg cagtaactgc gatagctaaa aggggcgaaa aggcttttct ttccgcggta 2215981 ccacccttgt ttacggcctg ttaatcggcc gtctcatgga tatttctatc cgctttagta 2216041 acgagtgaat caagttcacc cggccaagtc ctactgtcat ttcagactgg cactctgagg 2216101 cgagttcacc ttgtaaagct tcgccggttc tcagctaacc cggttctctg tggaaaactt 2216161 tatcaaggct acttatcctc atctgcgctt ttcatattca gccttcggaa cggctttcca 2216221 gctgttcaag aaggtcgttt gtttttcatt tttttagaat catactgcga tgattttcgc 2216281 ttgtgaagct tgcatttatc ttttgttgaa ctcatattac gccgctttgg acgcagtgtc 2216341 aacagcattt tttaaaatta ttagacaatt ttgattaatc aatctatatt gtatacgctt 2216401 tcattattgg tacaaaagga attgcaaatg ttaaaagttt ttataatttt tttattaatc 2216461 tatcaagaat acaccagaat tatttaattt tatataaaca tggaagattt tataacacga 2216521 tatggttcgt atatggattg agtctgacag atcatcttgc aatccatttc aatttcggat 2216581 aggcacttct cttgttccct cggcatacat taatgatatc ttgcaaagaa aaggtgatac 2216641 gatgaataaa tcatttgcag acatgcaagg atttcctgcg ggctttccaa gcttccccaa 2216701 ctttccgcag cagtactatc ctgctgtccc tcccttttac cagcaaagcc agcagccatt 2216761 tggaggctac ggatacggac agccgttcag tcaggcatac agcccgttaa ccactccctc 2216821 tggaatgtac tcctcattcc catacgcttc aggattttac ggacagcaat tttcaggtgc 2216881 aggctttagc ggccatggcg gcagcttaag tgctccagcg atacatgccg gcggattcag 2216941 cggggcgcca ggcgtacacg gaggctttag atattaaaga ataccacaag ggccgaacat 2217001 ctattgcggt ccttttattg ttttaaaacg acttcacaag tacagtcaca ttttctgtct 2217061 ttatatttgg aaacaggatg gaatatgatt aagatgaatt gaacgatatt ctgcacaatc 2217121 cgtaagtttt cgaggaggaa taaaattgca tataaaaata gacgatttaa ctggacgtca 2217181 ggtggtttca ctggtgaatg agcatttaca tagcatgacg cttatgtccc cgccagaaag 2217241 cattcatgcc ttaggtctag aaaaactaag agggcctgaa ataacatttt ggagcgcatg 2217301 ggaaggtgat gaactagctg gctgcggagc gctaaaagaa ctggacaccc ggcatggaga 2217361 aatcaaatca atgcgaacat ctgcatcaca tttaagaaaa ggcgttgcca aacaagttct 2217421 ccagcacatc attgaagaag ccgagaagcg aggctatgag cggttaagct tagaaacggg 2217481 ttcaatggct tcatttgagc cggcaagaaa attgtatgaa agcttcggtt tccagtattg 2217541 tgaaccgttt gcagactacg gtgaagatcc aaacagtgtg tttatgacga agaaattgtg 2217601 agacggcttt ataaggatag ataagtgcag gggaaggtct gtcttatcta tcttttttta 2217661 tattcacaca tttttcacct ttatgataca cgccaatgtt ttcaattttg tttaattcaa 2217721 agaacagcgg gaattacaaa cgacatgaac gatatcatgc aaattcataa aggaggagat 2217781 tgatatgaaa agcatagttg gtgtatatga aactccgcag gaaaccatcg cagcgattga 2217841 aggcttactt acaaaaggct atgattctga tgacatttct gttgtgacaa gccggcgaga 2217901 tacagattat ttggagtcac gtacaggaac agaagtcaat caagctatcg atgcacatca 2217961 ggacgaatct gaatcttttt tcgataaact gaaagattat ttcacaatgg atgatactgc 2218021 tacacacagc aaagcattat ccgacttgga tattaaaact gatgaaatag acaagtatca 2218081 agaagatttg gatgacggaa aacttctggt agccgtcgat acagatgcag atgtaattgc 2218141 tcctattgat aacggcaatg ccctttcagg cggcttttca agcacaaatg aattggatta 2218201 tacaacgaaa gaagaaaaaa cgatgccgct ccgggaagaa cagctgaagg tcgataagga 2218261 agacgttcaa accggcgaag tagaaatagg aaaagaagtg aaaacagaaa aaagagatat 2218321 ggacattccg gtgagacatg atgaaattta tgtcgaacgc cgtccagtgg atgaaaataa 2218381 aacggacgct gctcccgtca acgattcgga agagatcaga gttccaatcg ttgaggaaaa 2218441 gctggaagtg actaaaaaac cggttgtcac tgatgaagtg gttgtcggca aacgcactgt 2218501 tgaagaaaat gaacatattt ctgaaactgt gaaaaaagaa gaacctcgtc tgaataaaga 2218561 aggaaaagtt gacggcttgg atgatgatcc gttaaataac aaatgaaaat catagaccga 2218621 caacaaaaaa cctcaaatcc taaatggatt tgaggttttt cttttggtac gtcccaggag 2218681 agattcgaac tcccgaccga cggcttagaa ggccgttgct ctatccagct gagctactgg 2218741 gacacgtttt gtttttttgt ttttcgcttt aactatcagc gacaagattt attatatatg 2218801 ggatgcaata ataagtcaac ggttttttag aatttttttc atgaggaaga aaattttctt 2218861 cctcatgaca ttttcatagt gtgactcgat tttgcagatc ctcaatttca ttgcctgctt 2218921 ggtcgtaaaa acggactgtc gcagcatcat tttctaatgt cagtatagca tagctttctg 2218981 tcctgcgcac cctcggaagc cggatgctgc ctgggttaat catcagtttt ccgcgcagca 2219041 cttcgcttcc cgcgatgtgc gaatgcccga agcagataac atccgccccg agctcctctg 2219101 cacgatagta tacgtttaac aaggtctgtt ttataccgtg aaggtggccg tgtgtgacta 2219161 gtatttttct tgagccggca gtcagaagaa gctcgtcctt aaaatcgccg gcaaaatcgc 2219221 aattgccttt tacaaccgca taaggctcca atgcaggatg cctcgtctca agctcagagt 2219281 ccccgcaatg aatcatgaga tcaacttctg cctcatgccg tttcgcaatg gtttggagtt 2219341 cttcttcaag cccatggctg tcactgataa tcagcacgtt catgtacaag cttcctcctt 2219401 atgcctccaa aagcttagac agctttttaa gcgcgtcagc cctatggctg attttatttt 2219461 tttcatcact tgtcagttca gccatcgtct tatctttatc tttcacgata aaaattgggt 2219521 catagccaaa gccatattct cctctcggtt cttcagcaat atacccttca acatggcctt 2219581 cgactgtttt tgtttcctct ccgggaatac tcacggccag tgcgcagcgg aaacgggcgg 2219641 tgcgctgttc tttttcgata cctttcagct cgctgagcac tttttcgata tttgcctggt 2219701 cgtctttctg ttcccctgca tagcgggctg aataaacccc gggtctgccg ccaagattat 2219761 cgatggatag tccggagtca tccgcaatca ccattttgtt cactgctttg gcaacagctt 2219821 ccgctttcat aatggcattt tcttcaaatg tatggcctgt ttcttcaatt tcctctgtga 2219881 atccaatttc agctaaagat ttgacatcat agcctcttgg ctcaagaatt tctttgaatt 2219941 ccttcacttt tcccggatta tgtgttgcaa taattgcttc tttcatgatg atcaagcctt 2220001 tctgtcttta tttcagttct ggcagagaat cacccagcac ttctttttgc ttgtcaatca 2220061 gctcttggat tcctttttcc gcaagaccca gaagaccgtt cagatcctct ctagaaaaag 2220121 ttgcctcttc cccggttccc tgcaattcca caaaacggcc gctgcctgtc atgatgacat 2220181 tcatgtcaac ttcagcagag gaatcttctt cataatttaa atctaacaaa attccctgtt 2220241 ccttatcaat tccaacagag attgcagcaa gaaaatcagt gatcggattt gtcttgattg 2220301 ttcctgcttt gatcagcttg ccaatcgcaa tcgccatagc aagaaatgcg cctgtaatgg 2220361 aagctgttct agttcctcca tcagcttgaa tgacatcaca gtcaatccaa atcgtccgtt 2220421 caccgagctt ttccagatct acaacagctc gaagcgcgcg gccgatcagg cgttggatct 2220481 ccattgttct gccggaaatt ttccccttag aagattctct gattgttctt tggtttgttg 2220541 cccgcggcag catgctgtac tctgctgtaa tccagccttt ccctccgccc cgcaaaaacg 2220601 gcggtacgcg gtcctcaaca gacgcgttgc agattacctt tgtatttccc gctgttatta 2220661 gaacagaacc ttccggatgg ctgataaaat ccaaatcgaa tgtgattgga cgcagctcat 2220721 cgtgttgtct tccgtcatgt ctcatgtttt acctccgatt gtatgtacat aaaccatttt 2220781 tgtcccggaa ttgaataaag aaagaggcag ccggaacgct aacctctttc ttcctagtat 2220841 atcaaaaatc ccaatttaaa aactacccgt attcacttga gatggtctgg agaccggttc 2220901 tgtgagcttt tcgccttttt catttaccag ctctgatttt ccgttcactt taacagagac 2220961 gctttttaca tccggctgct ccgttaacgt cagcacaatg ctgttcagca cttctgaaga 2221021 aatcattttc gtcttctcat cggcgctgcc gaatatagat tgattgaaat ccaacgtcac 2221081 gcgcccgtct ttgattttcg gtttgctgac cagctttaca tcttcactga agtctgttaa 2221141 cagcccgctc accttgctcg gccctttagc caattcatta atggctgctg tgatgtcgtc 2221201 tttttccgaa ttgtcgattc gtttggtcac cggcacgtag tattcactgt cttcattttc 2221261 cgccaaatag tagactgtca gcggatgggt agcagtgaga tcatttacac cggctgtttc 2221321 caaattaatg ccgtctttgc ggcttaaatc atctgagatc ggcgtccctc ctacaggcat 2221381 ctccttcagt tcatgcccgt ttattctcag cttcacttta tctatcgaac taaattgcgt 2221441 cagcgtccac gtcacagatt gaacgatttt ctgttcgtct tctttcttat aatttttgaa 2221501 ctcattagag aaatcagcta tcgccgttcc atcttttttg atgtcaacgt taacggtggt 2221561 gtcagccggc aatacagctc tgaagccatt cggaagaatt tcagacacag gcccgccctg 2221621 tacgaggtat tcaagcgcct gcttagccgt gctctcactt ttaggaagag gcagcgtttg 2221681 cgcaacaaca tacccgtttt tatcaatgag ataaagctcc ctcataacag tagatgaggc 2221741 ttgatccgct tttgcggtat cgcttttttc actttctgtt tttttggctg ctgttgtatt 2221801 tgaattggca cccgcttcat cgttcacgaa tgtaacgtct tgaggcggat caatttcctc 2221861 ggctgcctta tcagattgaa acaaaccgca tccggataaa agcaaggcag aggtgagaca 2221921 agtggcacca atgactgcag gtcctttttt cagcatactt ttccctccta aggatgtttg 2221981 tactattatg tatacgagcc tctttaggaa atagaccgaa gaattccggc aaaacagaaa 2222041 aaaacccgca acataccgtt gcggggaaaa ctatctttta atcggttctt gcagtgagat 2222101 acattccaca tgcccgactt catggccaaa ccaatcgtct gcgatttttg caaactgatc 2222161 acgcgcccct gttgtcagga actgatgatc cggggcaatc ggagactggt tcagcagccc 2222221 tttataagag agaattgtgc tgacttcccg ggctgtttca tcgccggacg aaataatgtt 2222281 tacgtgctct cccatatatc tttgaatggc ttcttttaaa atagggtaat gggtgcagcc 2222341 taaaatcagc gaatcaattg atgtgtcttt taacggatac agcgaggttt taacaatctc 2222401 gtctgctgtt ttgtcgagaa acttcccgct ttccacaaaa ggcacaagca gcgggcaggc 2222461 aaggttttca accttcaaat cagggtttaa tgccaaaagc gcttcttcgt atgcattgct 2222521 cttaatcgta ttctctgtgc cgatgacacc gatatgctga ttatccgtca cttttatcgc 2222581 tgctctcgca ccaggctgga tgactccgac caccggtata ccgacgctgc gctggatgtc 2222641 atccaaagcg atcgctgttg ctgtattaca ggcgatcacg agcattttga tgtggtggtt 2222701 ttcgagtaaa taattcgtca gctcccacgt atattgaagc acctcttctt cagggcgcgg 2222761 cccgtaagga caccgtttcg tatccccgac gtagataata ttttctttag gtagctgtct 2222821 catgatttcc ttcgcaacgg ttaaaccgcc aaccccggaa tcaatgactc ctattggttg 2222881 ttccaacaaa atcgcctcat tttctcttca tttcatgctg cagtttcatc aaagattttt 2222941 cgaagatggc tatttcttca tctgtaaacg attcgaacat atcacgcaga tattcctgtc 2223001 tttttgtaat gacctcttgg ataatccgtt ctccttcagg cagcagatgt atcctgacaa 2223061 cacgtctgtc cgccgggtcc ttgacccgct caacaagctc atttttttgc atgcggtcga 2223121 ttaagtccgt tgtcgtgctg catgccagat acattttgcc cgataattca ccgattgtca 2223181 tatctcctaa ttcataaagc cattgcaagc cgacaaattg cggcggcgta atcgcatatt 2223241 ggttaaggat ttctcgtcct ttttgcttaa tgatcgcggc aatgtggcgg agtgactttt 2223301 caatatccgc aacatgctcc aaaggttttg atgtcatttg tccatccctc actcaaggat 2223361 ctcttacgca caaaagcgtt ccgtgtctat tttccttctt ttttgaagaa aatgcaagac 2223421 tcgcaggaga gaaatagagg actttagtca aacaacatca agaaataaaa tttaatttat 2223481 gacttgccta cgttttgcac agcattccaa atatggtttc gaatgttcca aacaaacagc 2223541 aataaccggc tccttccaaa agaaggaata ccggcaagga ttaaagctct agctcaccca 2223601 ttctaagaag ctcaacaacg gcttgcgaac gccctttcac acccaatttc tgcatggcat 2223661 ttgaaatatg gtttcgaacg gttttctcac tgataaatag ctcgcttgca atctcctttg 2223721 ttgtcttatc ttgaacgagc aattcgaaca cttctctttc tcttttcgtt agcagcggct 2223781 tcgattgaaa ttctttctcc ttcaagtatt gtaaccctcc ttgctaaggt gagagcgaat 2223841 cagaaacgaa tgggttttga tatagtcgag atatcatatg taagaagggc gcaggaggtg 2223901 acgtttacaa gataattagt ttatcgtgta tgaagaagcg tttctttctc ctcatccgtc 2223961 cagctgacag ccttgccgct ttcctttgag acttgaacca tcacgactgc cccggtgaag 2224021 cagggttcgc cttcgaggtt ctctccgaga tagtgcaagg taagagatga actgccgact 2224081 gcgcttgttt tcacatagat gcgcaactct tcataaggca tgacttggcg caaataatcg 2224141 cattgctggc ttgccacgac tgtcatggtc tgtttgtttt cactcatcat attcagcttt 2224201 ttaaaataag aaatccgcac ctcctcaaaa tatataaaag gggttacatt attcatatgc 2224261 ccaaacatgt ctgtctcgga aaatcttacg gataccttat tgaaaaaaga aaaggatgtt 2224321 ttccattctt gaaacggcat atcaatataa gcgggaagct tcatcttttt tcatctcctt 2224381 attgtttaaa aaaacctctc ccatgcggaa gaggtttttt cttcttatac tctgtcgctt 2224441 ccgaagaaat tgcggaacgc ttgtaagttt gtatctctat tcaaggctgc aatcgaagtg 2224501 gtaagcggaa tccccttcgg acaggattga acacagtttt gcgagttgcc gcaatctgca 2224561 aggccgcctt catccattaa tgcttctaat cgttcagatt tattcatggc gcctgtcgga 2224621 tgcgcgttaa acaggcggac ttgcgacatc ggtgcaggcc ccatgaactt cgatttgctg 2224681 ttcacattcg ggcaagcttc gaggcagacg ccgcatgtca tgcattttga taattcatat 2224741 gcccattgac gacgtttttc cggcattctc ggccccggtc ctaaatcgta cgtaccgtca 2224801 atcggtatcc acgcttttac ttttttcaat gaatcaaaca ttctgctgcg atcaacctgc 2224861 aaatcacgaa cgactgggaa tgttttcatt ggttttaaac ggattggctg ttcaagctgg 2224921 tcaataagcg ccgtacaaga ctggcggggt tttccgttta taaccattga acatgcgccg 2224981 catacttcct caagacagtt catatcccat gtgacagggg ttgtcttctc acctttgaca 2225041 ttaaccggat tccggcggat ttccatcaga gcggaaatga cgttcagatt cgggcggtat 2225101 ggaatctcaa attcttcatc ataaggcgtg ctgtcagctg tatcttgacg tgtgataata 2225161 aatcgtatgg ttttttgttc actcatgatt atttcgccac cttcttcttc gagtaatccc 2225221 gtttccgagg cgttatcagt gatacatcga catcctgata ctcaaattcc ggcgcttcat 2225281 acgggcttac atgtttagcc attgttgttt tgagccattc atcatcatta cgttcaggat 2225341 aatccggttt ataatgggcg ccccggcttt cattacggtt gtatgcgcca agggtaatca 2225401 ccctcgcaag ctgaagcatg ttcgagaact ggcgtgtgaa catcgctccc tggttgctcc 2225461 attttgtcgt gtcattgatg ttgatctttt tgaagcgctc cattaactcc tgaattttgt 2225521 catccgtttt caaaagcttg tcattatggc ggacaaccgt tacgttcgcc gtcatccact 2225581 caccgagctc tttgtgaaga acataggcat tttcggttcc gtccatactc ataatatcag 2225641 cccatttttc ttcttctttc ttaacgtgag cgtcgaataa agatgaagac atgtcttccg 2225701 ctgaagattc taagccgttt acatatttca ccgcattcgg accggccacc atgcctccgt 2225761 aaatcgcaga cagcagggag ttcgctccca agcggttgcc gccgtgcata gaataatcac 2225821 attccccagc cgcaaacagt ccagggatat ttgtcatttg atcgtaatcc acccataaac 2225881 cgcccataga ataatggacc gccgggaaga ttttcattgg aagcttacgc gggtcgtctc 2225941 ccatgaattt ctcataaatc tcaatgatgc cgccaagctt aatatcaagc tctttcggat 2226001 ctttatgaga cagatcgaga tataccatgt tttcaccgtt aataccgagc ttctggttca 2226061 cacacacatc aaatatttcg cgtgtcgcaa tatcacgcgg caccaggttt ccgtatgccg 2226121 gatatttttc ctccaggaaa taccatggtt tgccgtcttt atatgtccac acgcgcccgc 2226181 cttcaccacg cgctgattca ctcatcagtc ttagtttgtc atcgcccggt atggctgtcg 2226241 ggtggatttg aatgaattct ccgtttgcat aatacgctcc ctgctgataa acgattgacg 2226301 cagcagatcc tgtattaatc atggagttcg ttgattttcc aaagatgatt cccggtccgc 2226361 ccgtcgccat aatgacagcg tctgaacgga aggattcaat ttgcatgttt gtcaggtttt 2226421 gtgcaacaat tccgcggcag gttctgtcat catctaaaac agcgccaagg aattcccagc 2226481 cttcgtattt tgtgaccaga cccgcaactt cgtatctgcg cacttgctcg tccagtgcgt 2226541 aaagcagctg ctgtcccgtc gtcgcaccag cataagcagt tctgtggtgc tgtgtacccc 2226601 cgaatcggcg gaaatcaagc aggccttcag gcgtccggtt aaacatgacg cccatccggt 2226661 ctaataagtg gatgatcgaa ggcgccgctt cacacatcgc cttgaccggc ggctggttgg 2226721 caagaaagtc tcccccgtat accgtgtcat caaaatgttc ccacggagag tcaccttccc 2226781 cttttgtatt gaccgctccg tttatgccgc cttgcgcaca aactgaatga gaacgtttga 2226841 caggaacgat ggaaaacaat ttaaccgcca ttcctgattc cgctgcttta attgtcgcca 2226901 tgaggccggc aagacccccg ccgactacga taatgcttga ttgactcatg atagcccctc 2226961 tccctctagt aatctagtac tcttaaacaa atgcaaaaat cgcttttaag cctacgtatg 2227021 acagtgcaac aaaaataatc agcgtaacgt atgtcgaaat tctttgagaa cgaggcgtta 2227081 ccgtgatgcc ccatgtaaca gcgaaagacc ataaaccgtt cgagaagtgg aaaattgttg 2227141 ataaaacacc gacaatgtaa aaaccaagca tagccggaga gctcaaaata ttcgccatca 2227201 tgtcgaaatt gacctcagca cccatttgtg cggcaatgcg ggtttcccac acgtgccagc 2227261 tgacgaaaat gagggtgatg ataccggtta cacgctgcag gacgaatagc cagtttctca 2227321 tgtagctgta ttgaccggcg ttatttttcg cagtaaacgc tatgtacaca ccataaactg 2227381 catgataaat taatggtaag aagataataa aaatttccaa ggcatacctg aaaggcaggc 2227441 tatccataaa atgagcagcg ctattgaatg cttcagcgcc ccttgcggca aactggttga 2227501 cgactaaatg ctgaataaga aagatgccga ccggtatgac gccaagcaag gaatgcaatc 2227561 ttcgaaaata aaactctctg ttcccagaca ttactttacc ccctgtttga taagtgcgaa 2227621 atgtgctaaa tctcttcccc cacttctttc aattgtaagc actttattaa gatttattga 2227681 caatttcatt ttactcctcc ctcaaaaggg cgtcaagaaa acgcgtacat aaattataat 2227741 tttccgaatt gattagttga ttgaaaaatt ttattttatc aatatatatt tcttgcttaa 2227801 tttttcataa gaattacagg atcattctgt aatcctcccc cctgtttgag ctataatata 2227861 cgcaggagag aggggagaca gatatgaagt ctaaatttga agcatctatt gacaacctaa 2227921 aagaaattga aatgaacgct tatgcctacg aactaatacg agagatcgtt ctcccagata 2227981 tgcttggcca agattactct tccatgatgt attgggcagg aaaacatctc gcccgtaagt 2228041 ttcctcttga atcatgggag gaatttccgg ccttctttga agaagcgggc tggggaaccc 2228101 tcaccaacgt aagcgctaaa aaacaggagc ttgaatttga acttgaaggg ccgatcattt 2228161 ccaaccggct taagcatcag aaagaacctt gctttcagct ggaggctggt tttatcgctg 2228221 aacaaattca attgatgaat gatcagattg ccgaatcata tgaacaagtg aaaaagagag 2228281 ccgataaagt ggttctgact gtgaaatggg atatgaaaga cccagtgtaa tcaaaaaggc 2228341 ggtgactgca tagtcccgcc tttttgattg tcattacaca gctgaagggt gttttgaaag 2228401 ctcaaatgca tcgtgaagcg actcgactgc tttcaccatg tcattttcgc ttacgactgt 2228461 tgacactttg atttcagatg tgctgaccat tttgattaaa atgttttttt gcgccagtac 2228521 agcaaacatt tcagccgcta caccgggatt tgagaccatg ccggatccaa caatagatac 2228581 tttagccaat ttgctttctg tctcgatttt ctcaaattcc agcgcgtctt tatactcttc 2228641 aagcaccgca acggtttggt ctgcatcttc tgttttgaca gagaaggaaa ttccagtctt 2228701 gtcctcggcc tgcgtttgga taatgatatc cacgtttatg tttcttttgg caagtgttgt 2228761 aaaaatagta gacaaagttg tcaggccgct agtcagcccg taaatggtta ctcttgtgat 2228821 ttgatcttca aatgcaatgc ctctgacaat taaattctgt tccatggatg attcctcctc 2228881 aattaatgtt cccgcttcgg tttctgtact tgaacgcact tctaacggca cttggtaatt 2228941 tttcgcgaac tcaactgctc tcggatgaag aacaccggcg cctaaattgg caagctcaag 2229001 catttcatcg tatgagatgc cctcaagttt tctcgctgat ttcacatagc gcggatcggt 2229061 tgtaaacacg cctggcacgt ctgtgtatat gtcacattta tcagctttta aagcggcagc 2229121 caaagcaact gctgttgtat ctgaaccgcc ccggcccaat gtcgtaattt cacaatcctc 2229181 tgtcatgcct tggaatcctg caacaatgac aatttttcct ttttcaagct ggtctgctaa 2229241 aaccgaagtg tcgatatctg taattctggc gtttccgtga atggcctccg tacggattcc 2229301 cgcctgccag ccagtataag acacagcgtc atagcctttt tcctgcaatg ccattgaaag 2229361 gagtgaaatc gtgacctgct cgcctgtcgc cagcagcata tccatttcgc gtttgctcgg 2229421 ctggtcagaa atagcttttg caaggctgac caattcgtca gtggattttc ccattgctga 2229481 aacgacgaca acgacttgat ggcctttctg tttttctgca attgcgcggt ttgccgcatt 2229541 ttgaattttt tcgactgagc cgacggaagt gcctccgaat ttttgtacaa taagacccat 2229601 gtattaccac cctttacatt ttggttcgtg cgggtgagga gaaagagcgc tttgtccaca 2229661 ataaaaaaag caatgagagg aatactctca ttgcttatca attaatcatc ataaatgatt 2229721 atgaacaacg agatagccct ccaagaaaat gatttcttga cagccttaca tttattcaat 2229781 gcacggccag caaataatac cgatggggtt ttatttgctt cggcgacgct cccctttcag 2229841 cctttttcac agaatccatc tttctccaaa ggcatactct tgaagttcgc acctctatct 2229901 tcaccatata acacgatcta actatgaaat tagttcacat tttatcagat cttatttaaa 2229961 aggacaacat tatttttgca atttgtcgta aaggagctga gccgccgctg cgggaacacc 2230021 ggcttttttg atgtcctcaa ggcttgcttc cttcattttt ttaacggaac cgaaatgctt 2230081 taacagcatt ttctttcttt tctctccgat acccgggatg tcgtccaaaa cggattgaaa 2230141 cgcgcttttt ccccggattt gcctgtgaaa actgattgca aaacggtgca cctcgtcctg 2230201 aatgcgctgc aggaggtaaa attcctggct gtttcgttcc agatacgcca cctccagcgg 2230261 atcaccgatc agtaaatttg aggttctgtg tttttcatct ttcgctaaac cggcgatcgg 2230321 gatatccaag ccgagttcat tttcaatgac atcccttgct gcgttgatct gcccttttcc 2230381 tccgtcaatg ataatcagat cgggcagcgg cagattctca cgaagcactc tcgtatagcg 2230441 tcttctgaca acctctctca tagaaccgta atcatccggc cctgtaacag ttttgatttt 2230501 atatttgcgg tattcctttt tgtatggttt gccatcgata aacacaatca tcgcggaaac 2230561 cgggtttgtc ccctgtatat ttgagttatc aaacgcttca attctgtgcg gcgtataaat 2230621 atttaatgcc tcacctagtt tctgcactgc cccgattgaa cgctcctcgt cccgttcgat 2230681 taaagagaat ttttctttca atgcgatttt cgcattttta tgggcaagca tgagcagttc 2230741 ttttttcggg ccttttttcg gctggtgaac gtttgtttcc agtagctgct cgatcataga 2230801 ttgatctatg ctgtccggaa ctaaaatctc cttcggaagg aagtggttgt tttttgaata 2230861 gaactgcccg atgaacgtga ggaactcttc atctgcttcc tgataaagcg ggaacatgct 2230921 gacatcgcgt tcaatgagct ttccttggcg gatgaaaaag acctgcacgc acatccagcc 2230981 cttatcgtac gcgtacgcga acacatcacg gtcgactaga tcgttcatcg tcattttttg 2231041 tttttccatc gttgattcaa tatgggcaat ttggtcacga agctcttttg ctcgttcaaa 2231101 ctcaagattc tcagcagctt catgcatttt ctcttcaagc tcttttttga cctcattata 2231161 gccgcccctt aagaaacgtg taatgctttc aaccagctct ctgttcgtct cttcggaaat 2231221 atcctttaca cacggagcaa ggcattggcc cagatgatag taaaggcaca ctctgtccgg 2231281 gagcttggag cattttctga gaggatacag acggtcgagc agtttttttg tttcccttgc 2231341 tgcctgtaca ttcggatacg gcccgaaata gcgccctttg tcttttttga cattgcgggt 2231401 gacaatcagc cttgggtggc gttcatgggt gagttttatg aaaggatagg ttttgtcgtc 2231461 tttgagcatg acgttgtatt tcggatcatg ctttttgatc agattcattt ctaaaataag 2231521 cgcttcaaga ttggaggacg tcacaatata ttcaaaatcc tcgatttccg tcacaagcct 2231581 ttgggttttc gcgtcgtgag aaccggtgaa gtaggagcgc actctgtttt tcagcacttt 2231641 tgctttccct acgtagatca cagtctgctg ccggtccttc atgagataac aacccggttg 2231701 atcaggaagg agggcgagtt tttctttcag ttgtttgttc atatgttacc cttccttatg 2231761 tttaatcctt tatttccagt ttaacacgaa cgtttgtttt tctctatggt tcacaattgg 2231821 cgaataaaaa aagcgatccc tcaatcggaa tcgctctggc atgtaagcag cggaaaatta 2231881 aagatgtttg tttacaagct cttgaagcgc ttcttttggt ttgaagccga ctgaagtttc 2231941 aactacttcg ccgtctttta acacaagaag agtcgggatg ctcataacgc cgtattttcc 2232001 ggcagtttct tggttttcgt ctacatcgat ttttacgatt ttcagtttgt ctcccatttc 2232061 ttgatccaat tcttcaagaa caggtgcaat cattttacaa ggtccgcacc aaggagccca 2232121 gaagtctgcc agtacgacgc cttcgcttgt ttcagctgag aaagattgat cagttgcttt 2232181 tacgatagcc attattgaat tcctccaatg tgaaatgatg atttttagta tagcatctcc 2232241 cattcgttca cgctatttta atgcttacaa attatttttt cctgatcaca gccggtttac 2232301 tcatttttat atggttgaat gggatatgct ctttttttaa aacacaaatc tgataatggc 2232361 cccgatcact acaattgccc caataatcat taaaatggta cgaagcataa gatcacatct 2232421 cctcttcact gtcatgtact ttaccatgcc ctgccggagc tgttttaaaa cctgaaaaag 2232481 agcgccggca tgaagctccg gcgctcttgc gcgattaaga atcagcacgc agcgtaagta 2232541 agacgactga cattggcggg agttttactt tcagtttgtt tttgctgagc gtgtattgtc 2232601 tgaaggattc cggtttgaca tgatgaggat cgtcaaacgt gttatgcgca ttcatttttt 2232661 ctgccgtaag aatgactccg gaatggtccg ctgccttgtg taggcccctc agctcgattt 2232721 ccgcctctgc tttgttttgg tgatcgatgt tgcaaattgt gatattgata tcgccttcag 2232781 cttgtttcga cgctgaaatg ctgatttgcg gaagcgtttc accgttccat tcatagtcgg 2232841 cagacattgt ctctgtggct aaaagagaag cgtcctggtg caccttaaac atattgaata 2232901 catggtacgt cggtgtcaaa agcatccgct ctccctcagt caaaatcatc gcttgaagaa 2232961 catttactgt ttgggcgatg ttggccattt gcacccggcg gcaatgctga tggaaaatgt 2233021 ggaaatgaga agccgccacc agtgcatcac gaatggtgtt ttgctgatat aagaaaccgg 2233081 gattcgtgcc tggctcggga tcaaaccacg tgccccattc atcaataatc agcccgaccc 2233141 gctgctccgg atcgtaccgg tccataatcg tgccgtgttt ttgaatcaat tcatcgatgt 2233201 atttggcttt tttcatcgta ataaaccatt catcttccgt gaattctgtg gctgatcctt 2233261 tgcccttcca gaaatccccc ggaatcgtgt aataatgaag actcaacccg tccatcaggc 2233321 cagcggcttt tttcataagc acgtccgtcc aattaaaatc atccacattt gcgccgcctg 2233381 caattttata aatgtcattc ccgctgtaat tgcggacata agtctgaaaa cgccggtaca 2233441 gatctgcgta gtattcggga tgcatgttgc cgccgcagcc ccagttttca ttgcccacgc 2233501 cgaaatattt cagcttccaa ggctcttctc ttccattttg ctttctccag tctgacatcg 2233561 gcgtgccttc ttcaaatgtc atatactcaa tccactccga catttcctga acggttccgc 2233621 ttccgacatt gccgcaaata tatggctcgc attcaagcag ctcgcaaagc atcataaatt 2233681 catgcgttcc gaattcattt gattcaattg taccgcccca gtgagtgttc agcattgtct 2233741 tacggtcacc gacaccgttt gcccaatggt attcgtccgc aaaacacccg cccggccacc 2233801 taaggacagg aatgtgcagc tgtttgagcg cctccagcac gtcctttcgt atcccgttga 2233861 tattggggat gtctgagtcc gttccgaccc agatcccctc ataaatccct cttcctaaat 2233921 gctcagcaaa atgaccgtat atatttttgt taatggttcc ttttgcgata tctgtttgaa 2233981 tcactgcttg atgttcagac atgcctctga tcattccttt catacggata tgaaaagcac 2234041 cacagtcaaa tatgtgatct gtcgtttgcc tgaggagtca gcatgaatgt aagcgctttt 2234101 aaagtaacca tattatatat gttcgtacat gtcaacgaca ttttctattg tttttatatt 2234161 tgtacgtatg tatttataaa tatgaaaaaa cccggacttt taaagtccgg gatttccttt 2234221 atgagtgtat attcagctgt ttgaattcct cagttaataa cgggacaact tcaaataaat 2234281 caccgacgat gccgtaatcc gctattttaa agatatcggc ttcggggtct ttattgatgg 2234341 cgacgatcac cttgctgttt gacatgccgg ccaaatgctg gatggcgccg gaaatgccgc 2234401 atgcaatgta caaatccgga gtaacgactt tcccggtctg cccgatttgg agagcataat 2234461 cgcaataatc agcgtcacat gccccgcgag aagccccgac tgcggcccct agcacctctg 2234521 caagctcctg cagcggctga aatccttcct tgcttttgac tcctcggccg cccgcaacga 2234581 taattttcgc ttcggagaga tcaacaccgt ccgccgtttt tttcacgacc tcttggataa 2234641 cagtgcggag gtcagtaaga gaaacatcaa tgctttcgat gctccccgat ctgctggtgt 2234701 ctttttctga agcttgaatg ttattggggc gaattgttgc aaagatcatc ggatcggttg 2234761 aaatgacgcg ttcaaaagct ttccccgagt aaatcggccg tgtgaacaca acattccctc 2234821 cggtaacgct tacatctata gcatcagaaa ttaagcctgt ttgcagacgg gcagcaagct 2234881 tcggtgaaag atccttgccc attgccgtat gcccgaagat gactgaatca ggattttctt 2234941 gctcgataac acctctcatg acctggctgt acccgtctgc cgtgtatgtt ttcagcttcg 2235001 ggtcctcagc ggtaagaact ttatctgctc cgtaatgaat aagctcttgt gcaatgcttt 2235061 gtacattttc accgatgaga acaccgatga cttccccatc tcctgaaatg gttcttcctg 2235121 cagctattgc ttcaaaggtg acatttcgca attccccatc gcgtatttct ccaagcacga 2235181 tcactttttt tcccattcta acatccccct gtttctttga atgtccaagt tttaaatgac 2235241 tttagcttcg ctgcggagca atgaaacaag ctcttttgcc tgttcagcag gctcaccttg 2235301 gagaagcttc ccggcttctt ttttcggcgg cagaaaacgt tcaatggttt tcagctttgg 2235361 ttcagcatcc tcttcgtcca gatcaagatc atcaagttca agctcttcaa gcggcttttt 2235421 cttagccttc ataattcccg gaagcgatgg atagcgcggc tcgtttaagc cctgctgagc 2235481 tgtgacaagc aatgggagcg tcgttttgat tttttcaaca tccccttcga cgtccctttc 2235541 tgcttctgca tcagtgccgt tgatttcgag tttggtgatc gtagtgatac acggaatgtc 2235601 cagtagctcg gcaagccgag gcgccacttg tcctgatcct ccgtcaatgg caacatttcc 2235661 gccgagaatc aaatcaaact cctgatcctt catatagtgg tataaaactt gagaaatgga 2235721 atattggtcg ggttcatcaa gatcatcttc tatgttgatt aaaacagctt ggtcacaacc 2235781 catggcaagc gccgtacgca attctttctc cgcttcttca ccgccgaccg tgacagcggt 2235841 gatcgtgccg ccatgctttt ccttcagctg gatggcttct tctatcgcgt actcatcata 2235901 tggattaatg atccattccg ctccgtcatc ctgaatcttt cctgtttcaa tgacgatttt 2235961 ttcttctgtg tcaaacgtcc gtttcatcag tacaaataga ttcatgatca tatccccttt 2236021 tattcgcctt tgaactgagg ctttcttttt tcgagaaatg cctggatgcc ttccttggcg 2236081 tcctctgact caaatgcttc cccaaatcgc tttgcttcaa gctttaagct gccttcatag 2236141 gaatacacct tgttggaata aagaagttca agcaaagatg ccagcgtttg cgggcttttc 2236201 tctgcaaact tagcggcaag tgcttttgct ttttcaatca cttctgcctc atctttcgct 2236261 ccaattgaga caagtccgag atcaagcgct tcttttccgg atatcggttc tcctgatccg 2236321 atgagctcca gtgctttggc tgtaccgaca tatctcggaa ggcgctgtgt ccccgcaaaa 2236381 cctggaatga taccgagatt aagctccggg agccccagct tagcatcttc tgccgcgatt 2236441 ctgatgtgac aggccattgc aagctccagc ccgcctccga gagcagcgcc gtgaatcgct 2236501 gcgataatcg gttttggaaa actttcgatt ctctccatta actgctggcc gcgctcagcg 2236561 agcaatgagg aatcctcatt gcctttaagc gatgtaaatt ctttaatatc agcgccggct 2236621 gagaaaaatc ttccctcgcc gtgaatgata atgcttcgta cgcctgcatc tgtctcacat 2236681 tgatcaagac aggaagacag ctcttctaat atccggcttg aaagcgcgtt tgccggcgga 2236741 ttgtgaatcg tcaagactgc cacaaattga tcaaccgcaa gtgaaattgc attcatagga 2236801 cagaactcct ttacttattg tgaattccgg ataccaataa ttctaaaacg ctgtttgaaa 2236861 gcgcaacgag atcgtacttt tggtcattca tcacccaagt tgtcacagtt tcgtcaatcg 2236921 ttccaaaaat catctgccgg gcgaggcgga catcgaggcc ttcttttatt tcgcctgatt 2236981 gtataccttc cgtcaaaatg ccatccaaaa tatttaagta gccttttaat atttcgttga 2237041 ttttttggcg cagctccaag ttggattggc ggagctcaag ctgcgtgaca atggcgagat 2237101 tatggtcacc cgctaaaagg gaaaaatgct ttgaaatcac aagcgccaat ttctctttcg 2237161 ctgttgcttt ttctttaatg tcctcttcca tccgctcaat aaattgaccc attttttctt 2237221 tgaaaagaga aattaaaata tcttctttgt ttttaaaata gagatagatg gtgccgtccg 2237281 ctaccccggc ttgtttggca attttggata cctgtgactg gtggtagccg ttttctgcaa 2237341 tgacttctac tgctgcatca ataatctgca tatactttgg ccgtttttgc ttcaatgttc 2237401 atcgttcctt cctatagaaa tgaatgacta ttcattcata atttcatgat aagaaggatt 2237461 ttcaggtttg tcaagtttat tcataggcgt tctctttttt tatttgatat gatgattttc 2237521 ggtttcttct tcaagtaaac gccttcttaa aatttttccc accgccgttt tcggcagctc 2237581 ctttctgaac tcataggctt tgggcacctt atagggagct agacgtgatc tcgcaaaagc 2237641 gtccagttct tctgtatcgg cttttgcgcc tttctttaat acgacaaatg cttttactgt 2237701 ttctcccctg taggaatcgg gaacgcctgc gacaacaatt tcctggatgg cttcatgttc 2237761 ataaagcgct tcttctacct cacgcgggta aatattgtaa ccgccggcaa tgatgatatc 2237821 cttcttcctg tcagcaatat agaaaaagcc ttcttcatcc atatagccca tgtccccggt 2237881 gaacagccag ccatctctca gcactgcggc ggtttcctct ggtttattcc agtatccttt 2237941 catgacttgc ggacctttta caatgatttc tccatgctca tacggagcgg caagctcacc 2238001 cgtctcttca gaatagatcg cagcgtccgt actcggccaa ggacagccga tactgcccgg 2238061 cttgtttttt ccccagataa agttggcgtg cgtcactggg gatgcctcag acaaaccata 2238121 gccttccaca agctttccac cagtcacctt ttcaaatttc tgctttacct ccacggggag 2238181 cgcggctgat ccgctaagac agcttttaat ggatgacaga tcataatgct gcaattcagg 2238241 gtgatgcaaa aggccaatgt aaattgtcgg tgcgccagga aagagcgtcg gtttgtgttt 2238301 gtcgatgatt ttaagtgttt cgagcggatc aaacttagga agaagaatca tttcgaagcc 2238361 tagtttaatc gaatagttca tgactgccgt cagtccgtag acatgaaaaa atggaacgat 2238421 gcccagcact ttttcagcgc cttctttcac gtcatacatc caagcggcgc acatttcagt 2238481 atttgccaaa atattttggt gcgtgagcat gacccctttt ggagctccgg ttgttcctcc 2238541 ggtatactgg aggacagcga tatcatgctc aggatcgatc ttcgggattg tcaggagttc 2238601 agttttttcc tgcttcatac aggaagcgaa cgtgtgaatg ttagctgttt tgtcaaagtc 2238661 gatatgcact ttttgttttt gcgtcagcgg gtaaagaata tttttcggaa aaggcaaata 2238721 gtcttttaca ctggttatca aaatctggtc gactattgat aacgttttca tttttattgc 2238781 cttcgggaaa agcaaatcta aggtgatgat tacacttacc tgagcatctc taagctggta 2238841 ttcaagctca tgctcggtat aaagcggatt cgtctgcacc acgatgccac cggcaaacaa 2238901 gacgccataa taagaaatca ctgtttgcgg gcaattgggc agcataacag ccactctgtc 2238961 tcctttttgc aggccattgc actgcaaaaa agctgcaagt ttaagagcat ccgtcagaat 2239021 gtcatgaaag gtgagttttt ttccataaaa cgatattgcg gttttatcag ggaatcgtgc 2239081 ggcggagtct gtcaggatgg attgcagggt tttattcggc aacggaagct catgcgggat 2239141 atcgttggga tactcggcaa gccacggctt ttgagactgc ataaaacctc ccctttcgat 2239201 tttagagatc caccttatca ttatagcaga tggacggcaa aaaaaagaaa aagaaaggta 2239261 aatctttctt tttctcataa tatgaacaga tatataagac caattaacaa aaagattccc 2239321 gctgcggcga gcagtatttt cgcaagcttt tccatctatt ctccgtcccc ttatattccg 2239381 gctgccacca caaaagaaag cccgacagaa atgacaaatg aaataaagcc gacagcccgg 2239441 ttatcatttt cgatttcctg atcaatttta aaccgcggag tcaaaaactc aaaaataaag 2239501 tagctgatca gaagcataac aaacccgtaa acgccccagc cgatcatttg cagcagcgaa 2239561 ttatgctggg agatggaatg ctgaaatacg tttgcgattc ccaaaatttt tccgccggtc 2239621 gccattgcca ccgcaagatt tcctttttga atctcttccc agtttttata agccgtcacc 2239681 agctcaaaca cagtcaaaaa gaggacgagg cagagaaccg cgacactgta atatgccgcg 2239741 atttccacaa gctcgttttc ccaaaaatca ctcatggcca tactcccttt tattttagtt 2239801 caacaaccgt aacgcctgat cctccctcac ctgcttcacc gaaacgggaa cttttgacgc 2239861 tgcggtggtt tttcagaaga tcctgtacgc cttttcttaa agcgccggtt ccttttccgt 2239921 ggatgattga cactcttgga tatccggcta acaccgcatc atccaagtat ttttcaaccc 2239981 ggctgagggc attttcatag cgttcgccgc gaagatcaag ttcaagcgat acgtgatagt 2240041 cctttccttt gaccgctgta atcatttttt ctttttttgg ctccggagct gatttgataa 2240101 actccagatc tttttctttt actttcatct ttaaaatacc gatttgaacg ttccattcat 2240161 tgccgcctgt tttttcgagc aatgttcctt tttgcccgaa agtgaggact ttcacctcgt 2240221 cgccaggctt aaagtcgcgt ttttgcgttt tcggcttttc cggtttcttg gacttttcaa 2240281 aagcaggcat agcgccttct aaccgtttct tcgcgttaat cagctcgtga tccttgaagg 2240341 atttgtgttc ttcttttatg gtgcgcaatt catgaataat gtcctcggct tctttcattg 2240401 ccgcttttac tttttcagca gcctgctgtt ctgcctcttc aagcattttg tcttttttgc 2240461 tgttaagctc gatgatttgc tgctgcagct ctttatgcag tttttccgct tcttttctga 2240521 ttgattctgt ctcagaaagc tcttcttccg cacgtttttt gctttgttcc agcgacgcaa 2240581 tcatcgtatc gacttcgtta tgctcggccg tcatttctga cttcgcctgc ccgatgatat 2240641 ggtccgggag cccgaggcgt tttgaaattt cgaaagcatt gcttcgaccc ggcacaccaa 2240701 ttaaaagttt ataggtcggt gacagcgttt cgatgtcaaa ttcaacgctg gcattcatga 2240761 cgccttctct gttatagccg tacgccttca attccggata atgcgtcgta gctaacactc 2240821 gtgcattggt gcgatgcacg tcatccaaga tgctcatggc gagggccgcc ccctcctgcg 2240881 gatctgtccc tgcaccaagt tcatcgaaaa gcacaaggct gttttcattg acctgttcta 2240941 aaatgccgac aatattcacc atatgggatg agaacgtact taaactttgc tcaatcgact 2241001 gttcatcacc gatatcagcg aatacgtgct caaatactgc cgcttctgac ccttcatctg 2241061 ccgggatatg aagacctgac tgcgccatta aggttagcag gcctaacgtt ttaagggtga 2241121 ctgttttccc cccggtgttt ggccctgtga tgacaatggt tgaaaaatcg cggccaagct 2241181 cgatgtcatt ggcaacaacc tgatcaggcg gaagcaatgg atggcgggct tttttcaaac 2241241 ggataaagcc ggtgtcgttc ataatcggtt ttgtcgcttt aaccgctttt gcatatctag 2241301 cttttgcaaa aataaagtca agcgtctgca gcacttgcaa atctagaaat agctcctctg 2241361 tatactctgc cgttttctct gtcagcacac gcaaaatccg ttcaatttct tgcttttctt 2241421 tcactttcgc ctgctgaagg gaattgttca tatctacaat cgcctgcggt tcaatgaata 2241481 gtgtcgcacc agaggatgag gtgtcgtgca caattcctcc atagctggat ctgtactcct 2241541 gtttgaccgg gatcacaaag cggtcattcc gaatcgtaac aatcgtatca gacagcattt 2241601 tcgatgcgga agaggaacgc agcatcgact ctaaccggtc tctgactctt gattcgagtg 2241661 ttctgagctg tgtgcggatt cctcttaatg tttccgatgc atgatcaagc acttctccgt 2241721 gatcatcaat gcaggaatta atgtcccgct ctaaatcgga cagcgtgata agctgttcag 2241781 catgctgatg gatcagcgga atgtcgacac cgtcttcagc catttgcgtg ataaaatgtt 2241841 tcatttgttt aactgcataa agcaggcctg agatttcagt gaattcagaa ggactgagaa 2241901 cgctgccgat ttccgcccgt cttaacgctc ctctgatatc tacaaggccg ccaaatggcg 2241961 cttggcctct cagccggata atgtcagaag cttcgtctac ttcatccagc tgttttttga 2242021 tttcgtctat agaagcagaa ggcttaagct cgagaagcat ttcttttccg agcgatgaag 2242081 cggcatgccc aataacctgt tctttcactt tatgaaattc aagagctgat aatacttttt 2242141 gctgcacgat tgtgtgagcc tccttactta atcgttgcgc ttcagaaatg cctctacgtc 2242201 tttaagcgac cgggcattca gaacgttttt cgtttccgtc catcctttgc gcgcggcagt 2242261 aacgccagtt ttcatatcgt ctaacatctc aatattatgg gcatcagtat taatcaccaa 2242321 tgtaacccct tgttcgtttg ctttcattaa atgctctgtg cgcagatcaa ggcgcgcagg 2242381 gttggcattg agttcaagcg ccgtatttgt tttcctcgca agctcaatca gctgatcaat 2242441 atcgatttcg taaccggccc gtctgccgat aaggcgcccg gtcgggtgtg cgataatgtc 2242501 aacatgcttg tttgtcagtg ccgtctcaag ccgtttcata atcacgtgtt ccggctgatt 2242561 aaaactggaa tgaatcgatg caataacgat atccatttcc gcaagcacat cgtcatcata 2242621 atcgagcgta ccgtcaggca ggatatccat ctcaacgcct ttcaaaatac ggaagttttc 2242681 aaactctgca ttcagcgcgt caatttcttt tgcctgctgc ttaagtcttt ctgcagtaag 2242741 cccgttggcg acctttaaat attgtgagtg atcggtgatc gccatgtatt gatagccttt 2242801 tttgatgcag gcttcagcca tctctctgat cgaaaatgcg ccatcgctcc acgttgagtg 2242861 catgtggaga tcacctttga tttgcccgag ctctatcagt tcaatgctgt cgctgtaggt 2242921 ttccacttcc tgtccgcttt cacgaatttc cggcggaatc agcggcaggc cgaagtgcgc 2242981 ataaaattca cgttcactcg gaaatgtttt gatctctccg gtttcaactg tctcaacgcc 2243041 gtattcactg atccgctcgc cgcgttcttt ggcgatttgg cgcatcttaa tattgtgatc 2243101 ctttgatccc gtaaaatgat ggagtgttgt cggaaactgc tcttccgtca caagacggaa 2243161 atcgacgctt gtttcatatt caaaggaaag gatgacggac accttcgtat ctccgcttgc 2243221 gatcacgctt ttgatgtttg gcagctcaag aagctgctct cttacttcag ccggatgatc 2243281 tgtagcaatg atataatcca gatccttcac cgtttcccgc gctctgcgga gacttccggc 2243341 acgagaaaat ttgatgatat gcgtaaattg agaaagatgc tcctcaattt cccgcgcgat 2243401 ccggagggcg tagccgatcg ggaaccgttc aggctgtttt ccggcttccc cgagcgcctg 2243461 taatattttt tcttccgatt ttttgccgaa gcccgcaaga ccctggacct tttgctgctc 2243521 acaggcttcc ttcagagatt ctgcatcgtg tacgccgagc tctttataca gctttgcgat 2243581 ttttttgccg ccgagccccg gcagcttcaa taaaggcacg agtccttccg gcacttcttt 2243641 ctgaagcgat tcgagcgtgc ttgactttcc ttcatctata tactctttaa tgacgctgta 2243701 cgttcctttt ccaatgccgg acagcgacat catatcgtcc atttctgata agcttcggtc 2243761 gtcctgttcc agagctgccg ccgcttttcg gaaggcggat actttaaacg ggttgtcccc 2243821 tttgagttcc atatagactg caatggtttc aagcagccgg ataatatctt ttttatgcat 2243881 atcataaccc ccagacgttc acatatgttt ccatcatact tgaaaaaaac ttctccggac 2243941 aagagaagtt tttttatgcc ccgtactgtg tccacagctc ttgtaaaagc cctgacaagt 2244001 acggtgtatg gttaatgatc acatttgcga gagacgattg ccccatcatt tgctgcaacg 2244061 cgtctaccgg cagaacggat gcgacataca gcagcacaaa tgtaaataaa tagacttcta 2244121 gaaaaccgag aacggctccc agcatctggt tgatttgttt aatcaccgga atgccggcta 2244181 caatactcag gaacgagccg atgattctca gtaagatttt agcaatgata aataaaacga 2244241 taaacgcaat cgcattatag tacgctgctt ccaaattccc cgtaaaaaaa gaaagagccg 2244301 gctgtcccgc tgaaaaatcg ggtgcgggaa tccaatgtaa atgcggtgcc acgtttttat 2244361 agaataaagc cgcaaaggca attgataaaa taaagctcgt caagcggata aactgcagga 2244421 taaaaccgcg ttttaacccc agtaaagtcc ccatcaggag caagattaag atgatgatat 2244481 ctagcatagt tgttcaatcc ttttctttaa gctgacgctc cagtttttca catttctctt 2244541 gtaatttgac ataatcgtgc accacattta ccgctgtcag cactgcaagt ttatttatat 2244601 caaggtatgg atttttttca ttgatttctc tcattttatc atcaacaatt ccggcgacat 2244661 acctcatatg ggctctgctt tcttcaccga caatcgtgaa gtgctggccg taaatgtcaa 2244721 cggttgtttt tgtttttttg ccgtcagaca acgtttctcc tccattccgc gagaatccta 2244781 gttcttatca taacacgttt attaaatgaa tggaaagacg agcctcccgc tgttatgata 2244841 cactggtata tacagcgaaa agtgtaaaaa aaggagatta ttacgtgtcc cattcagtga 2244901 taaaagtatc gttgtctgct attgaccaaa tgaaaatgac gtacagcggt tcacttacag 2244961 cctctgttcc gcagggagcc gtttttcagg caaaaccgcc cggctgtacc attacagcat 2245021 atcaatcagg taaggtcttg tttcaaggaa aaaacgctgc ggcagaatcc gcgcgctggg 2245081 gaacagcaga gcctcaggaa aagaagaaaa cggccaaaaa gccggctgat ccccgctatg 2245141 cccctccggc agatatcgcc ggaatgtctg ttatcggttc tgacgaagtc ggaaccggag 2245201 attactttgg cccaatgacg gttgtatgcg cgtacgtcga caaaaccatg cttcctttaa 2245261 tgaaggaact cggtgttaag gattctaaag atttaaaaga tccgcaaatc atcgagattg 2245321 cccgaaacct gattaaaacc attccgtaca gcctgctggt gttaaagaat gaaaagtata 2245381 acagcatgca ggaaaaaggc atgagccaag ggaaaatgaa agctttgctg cacaatcagg 2245441 cgatcacaca tttattaaga aaattggatg gagtaaagcc tgaagccatt ttgattgacc 2245501 aattcgctga gccaggcgtc tacttcaatc atttaaaggg cagagacatt gtgaaggagc 2245561 ggacctattt tagcacaaaa gctgaaggta ttcacctggc tgtcgccgct gcttcaatca 2245621 ttgcaagata ttcattttta atggaaatgg ataaactatc acgcgcggca ggaatgacgc 2245681 ttccaaaagg ggccggtccg cacgtcgatg aagcggccgc caagctgatc ctcaaaaaag 2245741 gggcatctgc actcagaacc tttacaaaac tccatttcgc caatacgcaa aaagcgcagc 2245801 gccttgctga taaaaaacgt tcatagaaaa aagcttgcag atttctctgc aagctttttt 2245861 atcagcctct taaaacagct tgatatgtgt cttctaacgc tttcagcact ttgctgtgcg 2245921 cctttgtcac ttcttcttca gtcagtgttt gttcaggatt gacatactgg agtgagaaag 2245981 cgactgactt cttgccttcc tccatatgct ctccttcgta tacgtcaaat acggttacct 2246041 ctttcagaag cttgcccccg gcctctttaa tgacgctctc gagctgtccg cttgtgacgg 2246101 ttttatctgt tacaagagcg atatcacgtg tcacagacgg atattttgga atcgccgtgt 2246161 aaacaagcgg tgctgtttct gctgcgagca acgcatgaag atcgagctca aatacgtatg 2246221 tttcctttat atccagttct ttttccaatg aaggatggac ttggccgatg aagccgatca 2246281 gagaaccatt caataaaatg ttcgctgttc tgcccggatg cagctgtttg cgttcagact 2246341 gtacaaattc aatgctgtct aggacgttga gtttgtctaa cagcccttcc acaattcctt 2246401 tgacaacaaa gaaatcaact ggtttctttt caccctgcca tagctgcttg cgccataatc 2246461 cggtaacagc tcctgctacg cgttctgttt caacaggttt tgtgtcctct tccttcgtta 2246521 ggaaaacgga gccaacttcg tacagtgcaa ctgagtcagt ctgcctcgca agattgtaag 2246581 aaacagaatc aagcagattt ggaacaagac tgtgtctgag aatgcttctt tcttcactca 2246641 ttggaagcgc aagcacagta ttcagtgatt tttcaatcgc aaacgctgtc gctttcttct 2246701 cgtttgtcag tgagtaagtg atggcttgtg ataagcctgc gccttcaagg aagcgtctga 2246761 ctttacggcg ttttgcctga tatggcgtta atccgcctgt agttcccgct gtctcaggaa 2246821 gcgtagacgg aatgttatcg tagccgtaca gtcttgccgc ttcttcgatt aaatcctctt 2246881 ctattgtaat gtcaccgcgc cgtgatggga cagtcacaac gagaagatca tccgcttcac 2246941 cgaccgtaaa accgagacgt ttataaatgc tgatcagttc ttctttactg atcgtcaggc 2247001 ctagaacgct gctcactttg tcagcagata cgtgaatgtt atttgcttcg attgtcaggt 2247061 gatcttcctc aaccgttcca gcaagcacct caccgccggc atacagatgg atcagctgcg 2247121 cagcccgttc tgctgcaaga cgtacgcgtg ccggatcaat tcctttttca aatcttacgc 2247181 ttgattcact tctcaaacca aggtctttgg aagccttgcg aaccttctgc ccgttgaaat 2247241 acgcagcctc aagcaaaatg gttttcgtat cttcctgaac ctctgactct gctcctccca 2247301 tgacaccggc aacggcctgc gctttcgttc cgtttgtaat gacaaggtga tcggcagaca 2247361 gcttacgttc ttgatcatca agtgttacga tcatttcatt ctcagctgct tttcttacta 2247421 cgacttcctt agagccaaat ctgtcataat caaacgcatg aagcggctgt ccgtattcca 2247481 acaggacaaa atttgtgatg tcaacgacgt tgttgtgcgg acgaatgcct gcattcatca 2247541 gctttgtctg catccaaagc ggtgacggag caatcgtgac atttttaatg atttttgcag 2247601 tgtacagcgg gttcgcttct tgatcttcaa ttttgactga aatgtaatca gacgcttgtt 2247661 ctgaagcagc cgggtaatcc gtttgcggaa gctttacctc agtgtctaaa atcgccgcaa 2247721 cctcgtaagc aacaccaagc atgttcatgg catccgcgcg gtttggcgtt aaacccagct 2247781 caagaatcgc atcgtcaagc tgtaaagccg ctaaggcatc gcttcctgtt tcagcgtcat 2247841 tcgggaatac gaaaatgcct tctgcatact ccttcgccac aagtttgctt tcgataccaa 2247901 gctcctgtaa ggaacagatc atgccgtttg attcttcacc gcgaagcttg gcttttttga 2247961 ttttgaaatt gcccggcagc accgctccga ctgttgcaac tgcgactttt tgtcccttat 2248021 ccacattcgg cgcgccgcaa atgatttgta caggggcttc agctccgata tccacaaggc 2248081 acttattcag cttatcagca ttcgggtgct gctcgcgctc cagcacatgg ccgatgacaa 2248141 cgcctttgat gccttctcct ttgtattcaa ttccttcaac ctcaataccg gctcttgtaa 2248201 ttttttcagc aagaacagcc gggtccatgc cttttaaatc aacataatcc tctaaccatt 2248261 tataagaaac aaacatcctt gcatcctcct cttacgcctg tttaaactgc gaaataaatc 2248321 tgacatcgtt tgtatagaag tggcggatat catcaatgcc atatttcagc atcgcgatgc 2248381 gctcaacacc cattccgaat gcgaagccct gatattcctt cggatcaaag ccagccattt 2248441 taagcacgtt cgggtgaacc attccggcac cgaggatttc aatccagcct gttcctttac 2248501 atactgagca gccgttccca ccgcatttaa agcatgtcac atccacttct actgaaggct 2248561 cagtaaacgg gaagaagctt gggcggagtc tgatttcacg gtcttgcccg aacatttttt 2248621 tcgcaacaag ttcaagcgtt ccttttaaat cactcatgct gatgtttttg tcaacgacaa 2248681 gcccttcaat ttgcataaat tggtgagagt gcgtcgcatc atcgttatca cggcgatata 2248741 ctttacccgg gcaaatgatt ttaacgggac ctttgccttc atgcttttcc atcgtacgtg 2248801 tttggacagg agaagtttgc gttctcatca aagtttcctc tgtgatgtaa aagctgtcct 2248861 gcatatcgcg cgctgggtgt tctttcggaa gattgagcga ttcgaagttg tagtaatccg 2248921 tttcaacctc tggcccttcc tcgactgtgt agcccatacc gataaataaa tcttcaattt 2248981 cttcaatgac aacagtgagc ggatggcggc cgccgactgc aacagggttc cccggcagcg 2249041 tgacgtcaat tgtctgtcct gcaagcttct gtttcatttc ctcttcttca agcttctcgt 2249101 ttttgtcagc aatcgcattg gcaatacgct cccttacttc gttcgcgagc gcccccattt 2249161 ttggacgttc ctcagcagaa agcttgccca ttccgcgcag cacttctgta atcggccctt 2249221 tttttccgag atattgcacc cgaatatcat tgacaacctt caatgagctt gccgcttcta 2249281 cttgttctaa agcttcttgt tccagctgtt ttagcttttc ttccattttg catcctcctt 2249341 ttatgtaaac aaaccgtcat atgtctttgg aaaataaaaa aaacccgtcc cttgtacaag 2249401 ggacgagttg tggccgcggt accaccctta tttcagacag actgatgctg tcgtcagctt 2249461 cattgacata acggaatcag attccggttc acctttacgc gcagtgtacg cggtcccggc 2249521 gacaactcaa gaggtgaagc caatttccgg ctgcgttaaa aatgctctca gtcagcggca 2249581 ttttctccct ggaaagcagt tgatcagaaa ttgaggtcct ctgtcacggt ttttgaaata 2249641 ttatgttcta ttatagagaa atccaacgct tggcgcaaca ctatcctcgc aagtgataca 2249701 cgaggatggc agccgcaacc gcaacgttta gtgattcagc ctgtccgtaa agcggcacgt 2249761 acaggttcaa atccgttttt tccagcaatg cagcatctac ccctgcacct tcatttccta 2249821 caatgagcgc aaaggattca gactgaggaa tctcctggta aggcgctccg ttttgcagcg 2249881 ccgtgccgta tacttttacg ccctctgcct tcaattcgtc cacatatgaa ggcaggtttc 2249941 ttctcacaac aggaatatgg aagtgagatc cttgagcaga tcgcagtgtt tttccgttaa 2250001 aggcgtccgc cgtgccgtca ccgagtacaa ccgcatccaa accggccgca tcagccgttc 2250061 gaatcattgt gccaaggttt cccggatctt gaacagcgtc aatcagcagc accttgcgtg 2250121 ccgttgccag cttttcttca ggcatatggc acacagcggc aatctgctgc ggcgtttcgg 2250181 tttcagtcac agctgaaaac gcatcttcac tcagcatata gcactggata ccagtctcaa 2250241 gatctgaagg aatcctcgtt tcatccttta caaggatttc tttcacaatg cccgggcttt 2250301 tcaacgcctc ttcaacgagg tgttctccct ctatcagaaa tgtatttgtt tttgttcgtt 2250361 ctttttttgt gtgaagcttt ttccaatcct tcactttttg gttttttgcc gattctattt 2250421 gtttcactgt ctatgtggcg ctcctttttt taacatgatg ttattatatc gcaagaacag 2250481 cacataataa accaggtgca gggttagaat atacgtatta cattttagaa aaaggagcgt 2250541 tttacatgga tcttaattta cgtcatgccg tcattgccaa tgtcaccggc aataatcagg 2250601 agcagcttga gcatacaatc gtagatgcga ttcaaagcgg tgaagaaaaa atgcttccag 2250661 ggctcggcgt tttattcgaa gtcatttggc agcacgcatc cgaaagtgag aaaaacgaaa 2250721 tgctgaaaac gcttgaaggc ggattaaaac ccgccgaata agacatgaaa ccgggtgaca 2250781 gcgcccggtt tttttcttat ataataaaaa catgatgagg gggaacgcca tgtttttaca 2250841 gccgttatta gcgaaaaaaa ttattgctga agttaaaaaa atgtacgaac gtgaagtcat 2250901 tattgtaaac acggacggtc ttattatggc aggcacaaac gatgagcgtg tcggacaatt 2250961 tcatgaggga gcgcttatct gcgcaaaaga aagacgcagc gtgattatta caaaagaaga 2251021 tgaaacaagg ttaaaaggag tgaaagcagg cataaacctc cctgtatttt ttgaccatga 2251081 tgtgattgcc gtcttcgggc tgacaggtga gcctgcagag attcagccat tcggagaact 2251141 gcttcgaaaa atgacagaac tgttcattaa ggaatcgcgg cacttagagc aatcccagtg 2251201 gcgtgagaga atgctggagt cctttatgat cgattggctg caattaaagg agtggtctcc 2251261 cagttttctt gagaaagctc agcttcttgg tgttgacctt tcttcccggc gccaaatgat 2251321 tcttattcag gggtatgagt ggtcacctca tgatattgaa caaatggcac gcagctggaa 2251381 atcctcgtac cctgcggatt tgttcatcag gtggggaaat gaacggattt tgattaatca 2251441 tgaagtgccg cagcatgaac aaagggatcg gcttttgcgg aaaatccttc acatttgttc 2251501 gtttgccaat accgcaagca gccaatatac agcagctggc gccggaaggg ctgtcgcaag 2251561 ctccagcctg acagattcat acgagcaagc ggaaaaagcg ctggctgtca gccttaagcg 2251621 aaaaacgccc atatttgaag aggatctgaa gcttgatatg tgtctgacgg agatcagccc 2251681 gggaacccga aacgaatttc cgcaaagagt attaggaaag gcgctagagc atcaggaact 2251741 tatgaatacg atacggactt tctttcatca cgatttgtct ttgaaacaaa ccgctgaaga 2251801 catgcatata cacatcaata cattgcgtta tcgtctggct aaggctgaac agctgacggg 2251861 attacgtttt gaccgtaccg aggacgtcgt cacgatgtac gtcgcactct attttttaga 2251921 tcaagataca aaatagagag agtttcagtt tcattttttg tatgtttctc catggaaggc 2251981 tttgcttttt ttcttttaca atagattgaa agcgtttttt gacaggggga tgggtgaaat 2252041 gatcaccaag gatgtaaagg agcagctgat tcaggtctcc ggaccagaaa actttgatga 2252101 ctcgaatgcc ggccgtctcg tctattcata tgatgcgacg cctcagtatc agtctatgcc 2252161 tgatgccgtg attgctccga ggaatactga tgaaatatca cgcattttaa caatttgcag 2252221 cgaacatcga gtgccgatcg ttccaagagg atcagggaca aacctgtgcg gcggcacgtg 2252281 cccgactgaa ggcggacttg tgcttctctt taagcacatg aaccagattc ttgaaattga 2252341 tgaagaaaat ttaactgcca cagttcagcc gggcgtcatt acgttggata tgatccgggc 2252401 agttgaaagc aaaggtttat tttatccgcc tgacccgagt tctatgaaaa tatcaactat 2252461 cgggggcaac atcaatgaaa attccggcgg gctacgcgga ttaaaatacg gtgtcacccg 2252521 cgactatgtt attggactgg aggttgttct cgcaaatggt gacatcatcc gcaccggcgg 2252581 aaaactcgca aaggatgtgg ccggatacga tctcacacgt ctttttgtcg gctcagaagg 2252641 aacactcggc attgtgacag aggcaatcgt caaactcgtt ccaaagccgg aaacaaagaa 2252701 gacgctgctt gccctttatg aaaacatcga tgccgctgct caaacggtat cggacattat 2252761 tgccgcaaaa attatacccg ctacgcttga atttctcgat cagcctacac tattggtgat 2252821 tgaggattat gccaaaatcg gacttccgac aagcgcaaaa gcagttctgt taattgaaca 2252881 agacgggcca tttgaaactg ttgaacggga tatggaaaag attgaggcga tctgcaaaaa 2252941 aggcgacgcc gtatccgttc agaccgcaca aacagaggag gaagcgtttg ccctgactga 2253001 agcccggcgt tctgcacttt ctgccctagc ccgcctcaaa ccgacgacga ttttagagga 2253061 tgcgaccgtt cctcgctcag aaatcgccaa tatggttaaa gcgattaatg atattgctgc 2253121 taaatatgat atttccatct gcacctttgg tcatgcggga gacgggaacc ttcacccgac 2253181 atgcacgaca gacataagaa ataaggatga aatggaacgt gtcgaacagg cttttgccga 2253241 gatttttgag aaagcgattg aacttggcgg gacgataacc ggagagcacg gagtcgggga 2253301 aatgaaagcg ccttacttgg aaatgaagct gaaaaaagaa ggcattgatg cgatgaaagc 2253361 gttgaaagcg gcatttgacc cccggaacat attaaatccc ggcaaaatgt ttgcgaaaga 2253421 tgccagaaaa cgtgtggtgg cggaaagatg acaacagaaa aagaaatgaa acagatccaa 2253481 aatgaattta aagagcgtat ggatgaagga gagttattaa attgtatgcg ctgcggcttc 2253541 tgtcttcctt cctgtccgac ctatatcgaa tcgggatttc aggaaacaca ctctccgcgt 2253601 gggcgcatcg ccttaatgaa agccgtagcc gacggtatga ttgaaccgga tgaagatgtc 2253661 gaacggtcgc tgtcactttg cctcggctgc cgcgcctgtg agcctgtatg cccgtctggc 2253721 gtgaaatacg ggcagctgct tgaggaagcc agagatatta tccaccaaaa taaaaaacac 2253781 tctcttggtg aacgtgtcat gcgaaagacg gcttttcacg agctgtttcc gcatcaaaac 2253841 cgcatgcgct cagctgtaag ccttatcggt ttgtatcagc gttcaggact gcaaaccgct 2253901 gtgcgaaaat caggcatgct tcgggtcctg cctgagcatt tgcggacgat ggaagctgtt 2253961 cttcctgatg ttccaaaaag caaagacatg aaacatcggc cgcgtttcct gccttccatt 2254021 ggccccatga aaaaacgggt cgcctttttt tcgggctgct taatggatac aatgttttta 2254081 ccgaccaata acgccacatt gaagctttta cagctggcag gctgcgacat tgtcattccg 2254141 cctgaacagg cttgctgcgg ggcgcttcat ggacacagcg gtgaaaaaaa cacagggaaa 2254201 gagctcgcga aacaaaatat cgctgctttc gaagcattag acgtggatgc agtcattaca 2254261 aacgcaggag gatgcggagc ctttctcact gaatatgatc atttgctgaa ggatgaccct 2254321 gagtggtcgg aacgggctgc cgcttttgtt caaaagctga aggatttttc ttctgttttg 2254381 gttgaactcg atttccatca aatggatcta gcactcgaga cgcctcaggt cgttacctac 2254441 caagattcat gtcatctaag aaatgtgatg catacgtcac ttgagccccg ccagcttctt 2254501 aaaagcatca aaggggcgga attcaaagaa atggagaaag cagacagctg ctgcgggtca 2254561 gcgggaattt acaacatcgt cgaagttgaa atgtctatga aaatactgga cagcaaaatg 2254621 gctgccgtca aagcaaccga agcgatcctc attgtaacag caaatcctgg ctgcctgctg 2254681 cagatgaagc tcggcattga acgcgaagga ctaagcggta aagtcagagc cgttcacctg 2254741 gctgatttgc tattagaagc agccgggcac aaaacatcat gagaaagccc aaaacagaca 2254801 ttgttttggg cttttgtgcg ttattccatc ggactgcaaa tttcgatata atgtccatcc 2254861 ggatcagcga tataggcgac cgtctgcccc catggtttca ctttcggctc cccgataatc 2254921 gatacgcctt gttctctcat ccttttgatg accgcttcta cattttcagt aacaaacccg 2254981 atttcaaatg tgtttgaagc agatgtatcc ggaatgtcca gcgccgtgat gtctctggcg 2255041 ctttcccggg tattaagcgc caatatcgta gaccctgtat caaattcgac atacgtgccg 2255101 tgttcagcac gaatcggcag tcctaaaata tcccggtaaa aaatgaatag cccgcttgct 2255161 gtccgatacg tatagaataa gatatttcat tgatagattc attgccaacc cctctcagca 2255221 ttttcaatag tccttctagc ccggtataga tgcttccatc cttaagctcg gatctttcca 2255281 catctgcgcc cattttttca cagccgccac gataatgatg aagcctaaca ccagcatgat 2255341 gatagataat acgccattca atacactata tcctgctgct tcaggattga gatacacatt 2255401 gcgcaccatc caatagcccg cataattgac agtgacatat aaataggcaa gcgggataag 2255461 gcaagtcaga atgtaccggc gtttatcggc gattttcagc acgatcgtcg ctccgataat 2255521 cagccccact gaagccatca gctgattaga aacgccgaag agcgcccaaa tggaaccgat 2255581 atctcctgaa tacagcaagt acccccacat caaacaggca agcgcgctgg caaatacaga 2255641 gcccggaatc cagtctgttt tcttcagcgg cttatacacc tccccgaaga agtcctggat 2255701 caaataacgg gcgacacgtg tgccggcgtc aatcgctgtt aaaataaaga ccgcttcaaa 2255761 cataatgaca aattggaaaa agtatgaggc caaatggctg aaaaacggca ttccggtaaa 2255821 aatataagtc atccctaccg caagcgtgac ggctccccct gttcttcctt ctaagtccaa 2255881 accgatttcc ccgctcaatt caggcaaatg tacgacattc atgccaagcg tacggaaaac 2255941 ctcaggcgtg ctgttaatcg caaagtaatc agcaggctgt aaagcggtcg ctgcaatcag 2256001 cgccatgata ccgacaagac actcaacaag cattgcgcca aacgcaaccg gcttcatatc 2256061 actccattta ttcagcattt tcggtgtcgt tcctgagccg acaaaggcat ggaacccaga 2256121 gatcgccccg caggcgatgg ttattgagat gaacggccag acaggtcctg ccagcaccgg 2256181 ccctccgcct tttacgaatt ctgtaaacgc agggaacgga atggacggat tgacgacaaa 2256241 cacaccaaca atcaaagcga taaaaacacc gattttcata aagctgctta aataatcacg 2256301 cggagccaga agcagccaaa cgggaagcgc agccgcaaaa aacgcataaa caggaagcgc 2256361 gattgcaagc gttttcgtat ctagcgttaa aaagtcaccg agcgcggtag tctgtaccca 2256421 tggaccgata aagactcctg ccattaaaaa gagaaagccg accgttgaag cgagctttaa 2256481 atttcccgtt ttcttataaa ataagcccac acccatcgca atcggaatcg taatccccac 2256541 cgcaaatgtt ccccatggat tacgttcaag cgcatgcaag acaaccatcg acaggcccgc 2256601 cattgtgatc gtgatgataa acagcatgga cagtcctgta caaaatcctg caacagggcc 2256661 aagctcatcc ttcgccactt ccgacagcga ttttccgttt ttgcgcatcg atgcaaacaa 2256721 caccacaata tcatggacgg ctcccccaat taccgccccg attaacagcc acaataatcc 2256781 cggcaaatag ccaaactgcg ccgccagaat tggtccgacc agcggcccgg ccgctgcgat 2256841 cgcggcaaag tggtggccga acgaaaccca tttatttgta ggcacatagt ctttcccatc 2256901 ctcaagcgca tgagcaggtg ttggcttgtc atcattcact ttgagaacct tcaccatcat 2256961 aaatgttccg tataaacgat aggcaatagc caaaatacac attgatgcta tcacaattgt 2257021 aaccgcattc attttctccc atcccctttt ctgtttttca taaatatatc ataatttcat 2257081 ggtgaaaagc ggtcattttt tcctatacaa aaagccggct ggaatgggcc ggctcgtggc 2257141 agttgaaaga caagccggag agaaatctcc ggctttgcta ttcttatgac tgttttttca 2257201 ggcggatcac attccaggaa agcggcgtga aatgagcagt taagccgttt tcgctgacag 2257261 acgatgatcc gttggaatgc ggaacgacat tttttctgtt atgctggttt gttgctttga 2257321 tatcctgatg ctcaagtacg atgtgctctg cgatttggta ggattcaaag cctctgagcg 2257381 aaatctccgt ctccatctga tcctcagcct tgtttaccgc aaaaatagtg agtgtttctt 2257441 cctcttcaga gtacacaaca gcagcatcaa catatggcac atcagtgaaa tcagaacaat 2257501 cgtacttagg agaagaaata agcggtttca gtgactcgcc ccttccgtaa acagaagcat 2257561 gcatgtatgg atagaaaatc ggctgtctcc atgcttctcc gcctttttcc gtcatgatcg 2257621 gcgcgatgac attaacaagc tgtgcaagac acgcaatttt cacacggtct gcgtgctgca 2257681 gcatcgtaat gagcagagag ccgactaata aggcatcttc aaaattgtaa atatcctcta 2257741 aaatcggacg cgcagtgatc cacggctcga cttttttatc agcctcattt gagtggtacc 2257801 agacgttcca ttcatccaga gagagattga tagttttctt gctgcgtgtt tttgctttta 2257861 catagtcaca ggtcgcagcg actgatttga taaaatgatc caaatccata gaacgtgcca 2257921 agtagtttgg cagattgtta tcccggtttc cgtagtaagt gtgaagagag atatagtcga 2257981 catgctcata cgtatgctca agcaccttcg cttcccaatc gataaaggtc ggcataccgc 2258041 tgtttgagct gccgcaggca acgagttcaa ttgatgggtc aacccacttc atgacctttg 2258101 ctgtctctgc ggcaagccgt ccgtattcat cagctgtttt gtggccgatc tgccatggtc 2258161 catccatttc gtttcctaag caccatgttt tgatgccata cggctgttca tagccatgcg 2258221 atcttcttaa atcactccag taagagcctt tcggatggtt gcaatattca acgagattac 2258281 gggcggcatc tatgcctctt gtgccaaggt tgacggccat attgacctca gtgttcacct 2258341 tttttgccca agataaaaat tcatttgttc ccacttcatt ggtttctgtc gtttgccatg 2258401 ccaagtcaag ccgtctcggg cggttttcga ctggtccgac accgtcctcc cagttgtatc 2258461 cggataaaaa gtttccgccc ggatagcgga tgatgggaac ctgtaattct ttgatcagcg 2258521 actggacatc ttttctaaat ccatcttcat ccgcttcagg gtgatcaggc tcgtatatgc 2258581 cttcatatac cgcacgaccc atatgttcga taaacgagcc ataaatccgt ttatctactt 2258641 caccgatttt atattctttg tctacaatca ttcgcgcttt tttcatcaca cgtttcctcc 2258701 ttcattaacc tttgactccc cctaccgtca ggccggagat aaagtacttt tggaaaaaca 2258761 agaaaatgat aatcaccggc aaaatcgcaa atactgagcc ggatataagc atgtcgtaat 2258821 tatttccata agggctcagc aagctggaca gccctattgg aagcgtaaac atttctttcg 2258881 accgaagcac aatcagcggc cacaagaagt tgttccagct gtttaaggac tgaaggataa 2258941 tcatcgcacc gaaagccggt ttcatcagcg gtgccataat cctgaaaaag atgccgaatt 2259001 ccgtacagcc gtccatcctt gcagagtcca gcagatctct tggaaggcca agagcatatt 2259061 gcctgaaaaa gaaaacagca acaggtgaaa cgataaacgg caatatgaca cccgtatatg 2259121 aatcgatcaa gtgcagtccg acagtaagtt taaacagagg aagcatcatc acttccagcg 2259181 gaaccatcat aataatcagc acaagaacaa agatgatatt tctgccctta aaatcataaa 2259241 ccgcaagccc gtacccgatc atcgaagaaa aaaacagagt gagcacagtc gtaaaaagtc 2259301 cgagtacaag actgttaaaa aaccatttga aataaatgct gccgccatta aacagaaatg 2259361 tgtagttatc aaaactcatc acttttggat caatatcaag attcagcccc acacgcaaaa 2259421 gctcagatga cggctttaat gatcctaaaa gcaaacagaa aatcggaaaa agatacaata 2259481 ggctcagcat cataaaaaac agggtcagcg caattctata aacgctaaac tgaggactgt 2259541 gccgcaacat ttatccctcc cccttaaacg agcctgacag ctttaatgaa atcaggctga 2259601 caacaaggat cacaatcaaa agcacaatgc cgatggccgc tccgtatccc atttcattgt 2259661 aggcaagtcc ctgctgatac aaatatccga caagcgtcag accaatatta cccggggaat 2259721 tattctgcca aaggacgtag ctttcctcaa acatcctgaa gccgccgatg atgctgatgg 2259781 tcagcacata tacggttaca ggcttgagaa acggcagcgt gatgtgcaga aattttttca 2259841 ttgtattcgc gccgtctata tcagcggctt cgtacagctc tttcggcaca ttttgcaaac 2259901 ctgctaaaaa gtaaaggatg ttgattccca tccatctcca tgaagcaagc agcaccatca 2259961 aaaacatgcc ggtatgttca ttgttcatcc agttctgagg tgaaaagccg agtttaagta 2260021 ggatggaatt ggccagagac gtttccattt ctccgaagat cagccgaaaa atgatccccg 2260081 cgacaatggt tgaggtcaat gccgggataa ataatgctga tttaaatata tttctaaatt 2260141 tgaccagctt tgaattcagg aatatggcca gaagcaatgg aacaggaatc agcacgatca 2260201 gcgtccaaaa ggtgtattcc agcgtattcc aaagggcggt atagaacgtc gggttgttta 2260261 gcgctgtata attagacaat ccgacaaagg acacctctcc cggcaaaatt ctttggaagc 2260321 tcatgatgaa gacactaatg atggggtata gaaaaaatac gagaaaggat aaaacgaatg 2260381 gcgctgtaaa cagatagggc gccgcttttt ttgaataaaa cagatctcgc cagcctgatt 2260441 gtttcgcagc tgaaggaacg ggatgaaccg ttcccgtttt cacaggtttc atgagaacct 2260501 ccccgctttc actttttgaa tgggattcta tttctgtttc agttcacctg ccgctctgtc 2260561 caaggcttgt ttaggcgttt tttgctgaga tttaagcgcg tcgaacaata cgcttctgtt 2260621 gacaaggtct gaagccttgg caaaatcctc atgtaaataa attggattga tttcatcctt 2260681 gatatcgagc agcacagaaa aaatgcctgt tccgttttgg aagtaatccg tgtatttgtt 2260741 tttctctttc aattccttgg agctccaaac atcccagcga agcgggtcaa agccgagtac 2260801 gctccagagt tttttatttc cttcttcaga gcccttcgca aaggccaaaa actcttttgc 2260861 taactcaaca tgcttggatt gcttcggtac aacagttgcc gtaccgccca aacctgccga 2260921 gcggtcgccc ccctctttcc atgccgggag cggtctgatg gcaatcttcc ctttcagatc 2260981 aggcatataa tcgataaatc ttcccatata ccaaatcggc atgagaactg aagcagctcc 2261041 tccttggttc ataaagccgt agtattcttc actgtgatgc ccgccgcccg gcgcaggaat 2261101 catcgtttta tcattgatca tgtcttttaa atattgaagt gtttttacgt tggtgtcatt 2261161 attgaggatc agcttgccgt ttttatcaaa atagcctgag ttttgctgtg aaatcataga 2261221 taagaacgtt gcggaatcat ttgtttccac cgttcccatc ggcttcccgg tcactttgcg 2261281 cactttctgt ccggctttat ggtaatcatc ccatgtttta atatcgtcag gattgacgcc 2261341 ggcttttttc atcacatcca tgttataaaa catgaccgtt gtccctacat gtgtatcgag 2261401 tccgtaaagc tttccgtttt tgctgtacaa tgtcagccgc gcctcaacga atttatcgcg 2261461 atccttttca atcagcggag tcaagtcggc aagcggtatg tcagagccct tcaaaaagtt 2261521 tgaaaaacgg gccaattcga catctgcaat atcaggaacg ccttctcccg ctattaggga 2261581 gatagataag ttatcgtgca tttgtccata tggataaacg accgtattca gcttaatttt 2261641 gcggtcagga tattttttgt tccattcctt caccatttcc acatagaact gctcatgaag 2261701 cccgttaaat gtccaaaagg tcagctcagt ttcacccgat ttgccggatg atttttctgc 2261761 tgaacacccg gcaatgacta atgtcagcaa catcatgagc acaagaaaac agacagtcat 2261821 ttttttcatc tgcgttaccc cttccattcg aggtgcgggc tattcatata gaccatggtt 2261881 gatcagcgtt ttgttttcat tgatgattct taatccggtg catcggtctc ttaaggtgtg 2261941 cgcgtgtctg aaggcatttt tgacggaatc ctgcccgaca ccgatttcgt caaaatacgc 2262001 agggcctccg gctgatctca gccaatcagc cagcacttct cctctcggga gtgtttgata 2262061 agccgattgg atggcttccc ggcggcttgg tgaaaattcg ttcagcccgt catcctgagc 2262121 gagctttctg tatgtgtcag ttaataaaac agcggcacag cccacctttg ccccatgaag 2262181 aatctgaggc cgttttttct ccattaactc catttcaatc caatgtgaaa tatgatgctc 2262241 gccgcctgat gccggtcggg aatgatctaa tgccagcatg acaagccccg atacaagtaa 2262301 agactccatc aaaacccgta tgccagtttc cgttttcatc gcaatgtctt ctgtgtgttc 2262361 aatgcaggca gcaagcgcct cctgaacgat cttagctcct gcaggcgaat aaggctcacc 2262421 ggcaagatgc cgggatattt cccaatctgc taaagacgtg attttaccga gcatgtcacc 2262481 aaagccagcc gccaccattg actgcggtgc cgcttttaat agatccagat cagcgaacag 2262541 cgcagatggg gccttcgttt gaatggttgt tttcgtgccg tataaaataa tcggcgcacc 2262601 ggctgatgta aaaccgtcta cagatggagc agtcggataa gaaataaacg gcaaatctct 2262661 ttgaaacgcc gcaaagcgga cgatatcatg aatcgtgccc gaaccgactg cgatcatgac 2262721 atccgttggt tgtttcgtat ggatcagcac atgaatgagc gatcgttcat cagctgtcac 2262781 atctccggct tcattttctg gaatgatcag gcactcggcc tgaaatcctt cttgattcag 2262841 tcggttttct aaatcaattc ctgcaatgcg gtgtgtattc gcgtcgcaga caaggacaat 2262901 atgttgattg ttttttcgtt ttacataatc caaaagcgaa tcagctgctt gcttaccgag 2262961 aacaatttct tcaactttta taggcaacgt cttttctccg gcgttttcaa aagcacgctg 2263021 aacgtcagct gcgatacgat tcatatcaga atcccctcct cagccaattt ggttacatcc 2263081 ttaatagaat ccagcacata atccggcgtg tacaaacgct gttcaccctg tttcgcagaa 2263141 ccagttagca ctaaggcgct tttcatgcca taaagcttcc ccatcgcaat gtcagattca 2263201 atgctgtctc ctataatcat gcattcatgt gcggacagcc ccattgctgt acaggcagcc 2263261 tccgccatca gccatgacgg ttttccgaca acaagttcag tcttcgcttg tgcagaagtc 2263321 tcaattgccc cgatcattcc ggccacatca atggcatttc cgtcttcgtt cggaaaagag 2263381 cggtctttgt ttgtagcgat aatacgagcg ccgccggcag ccgcttgaaa ggcttgattt 2263441 aaatcgtcgt acgtgagcgt ttcatgaagg gagatcacga gccaatccgc ttccttcggt 2263501 tcgctcgcgt tctgcacacc ggccagcctc agctcgtcaa ccaagccttg ctccccaagc 2263561 acccatacct ttgaaaaacg ataatgtttt ttcagaaaag ccgctgtcac gcttgatgac 2263621 agaacaatgt cgtttacgtc cgtttcaatc cccgcgccaa gaagtttttt tctgcacatg 2263681 gcacgggaga tattcccccg gttgcttaaa aagacgattt tctttcccat tctcctaagc 2263741 gttttgatcg cttctcttgc tccttcgatc aactcatttc ctctgaatac agtaccgtcc 2263801 aagtcaatca gaatgccagc cggtgacaca ggcgtatcat gactggccat aatacgcatt 2263861 tgctccgtgt tttcgataaa aatgcttttc atgcaggact gtattgattg gggttacatc 2263921 cttgttcagc ataatggagt gataggccat ttcggcaacc gtttctaata caactgcgtt 2263981 atgaatggca tttaaggcgt cagtgcccca gcagaacggt ccgtgattat tcacgagcac 2264041 acccggcacc tgttcgtaat tatgatgctg aaaggtttcc gctatgactt ttcctgtatt 2264101 cagttcgtag tcatgaatga tttcttcatc gtacatttct cgagtacatg gaatcgcact 2264161 gtcaaaataa tcagcatggg tcgtgcctaa cggagggatg tctctgcccg attgcgccca 2264221 gcttgtcgcc cattgagaat gggtatggac aattcccccg atattcggaa aggctttata 2264281 tagataaaca tgggtaggtg tatctgaaga aggtttaagc gagccttcga cgacctctcc 2264341 atcaaggttc aaaacaacca agtcatcggc tgtcaggtcg ctgtattcga ctccgctagg 2264401 tttgatgaca attctttctt tttcacggtc aatgccgctg acatttcccc acgtaaaggt 2264461 taccagctga tgctcttgaa gcttcaggtt ggcagccagc acttcttttt ttaatgtttc 2264521 aagcatgctc catcaccctt tatcaattct ttttggcggc agatgaaaat tgaagatttt 2264581 tgatcgtttt cagacgcttc atgacatggt tttcttttcc gaaataatga accagctctt 2264641 tatattcagc gtacaatttt tcataaaccg cggcgttttc ggcatttggc gtataagtta 2264701 tatctttcag ttttcccatg ttcgccgctg cctttttgat atcatcgtag ccgccttttt 2264761 ctttgcctgc tgcaagcgcg ccgaaaatgg cagatcctaa ggctggggct tgcggtgaac 2264821 cagagatttt aatgtccatg tttgtcacat ccgcataaat ctgcatgaca aacgggtttt 2264881 tctcagctat tccgccggct gcgaacagtt cctcaatcgg aacaccgctt tctttgaatg 2264941 tttcgataat catccgggtt ccgtaagctg tcgcttcaac taacgctcta taaatctctt 2265001 caggcttcgt cagcagtgtc atgccaagca gcatccctgt taaatctgca tcaacaagag 2265061 ttgaacggtt tccattccac caatctaaag caagcaagcc gctttcacca ggcgcttgat 2265121 ggtttgcttt ctcactcagc agctcatgaa cgccaatgtt tttttccttt gcttcctctt 2265181 gataagctgg cgggacacat gttttcacaa accagtcaaa atgatcgccg acacaggact 2265241 gcccggcttc atatcccgca tagcccggga gaattccgtt gtccacaacg ccgcacattc 2265301 ctggaacgat atgcacctct tcaccaagta gaacatggca cgtcgaggtt cccataatca 2265361 tcagcatttt ccctggctct gtaatgccga ccgccggtac cgaaacatga gcgtccacat 2265421 tggcaaccgc aacagccgtt cccgggagaa gccctgtcag ctttgccatt ttttcagtca 2265481 gactgccggc tttttctcct actgaatgaa tagaacctga caatttgtcc tttgtaatcg 2265541 ttttcattga aggatttaat ttctcaaaga aatcatctga cggatacccc gctttttcac 2265601 tccacatcgc tttataccct gcggtacaat tgcttcgctt gagcgagccg cacagctggt 2265661 acacgatcca gtccgcagcc tcgatgatcc ggtcagccgc ttcataaatg tgaggcgctt 2265721 cctcggcaat ttgcatgacc tttggaatca tccattctga tgaaattttt cctccgtacc 2265781 gctgtaaaaa agcctctcct tcttcttccg cgatttgatt gagccgatca gcatgttttt 2265841 gggccgcatg atgcttccag agcttcacat agctgtgcgg ctcctcttca tattcaggca 2265901 gcatgcataa cggctgcccg ctgctgtcaa taggaaggat cgtacatgcc gtgaaatcaa 2265961 ttccaatccc gataatgtct ttcgggtcaa cgcccgtctg ttcgagtaaa gacggaatgg 2266021 ttgtttccaa gacttcgagg taatcagcag ggtgctgcag cgcccagtca cgcggcagct 2266081 tttgacccgt ttttggaagg acggtatcaa tgacagcatg cctgtattct tttacagcag 2266141 ccgcaagttc ctcccctgtt tggacatgaa cgagcactgc tcttcctgat aaagttccaa 2266201 aatcaacccc tattgtgtaa gccatgtgac atccccctct acttttgaag ccggtaaagc 2266261 gcctcgttcc attttaactc gtgtttcagt ttatgaattg tcgtatcacg ggaaatgaga 2266321 acactttcga ttcccgccat ttccgcccaa tcaagcattt gctccgctgt cagttcataa 2266381 gacaggcagg tatggtgtgc accgccggct aaaatccatg cctccgctgc tgttttcaat 2266441 gacggctccg gcttccagag aacacgggca accggtaaat tcggcatgtc tttttcaatt 2266501 tcctggccgt tgacttcatt cagcacaagg cggaaacgcc cgccaatatc aacaatgcta 2266561 gcttgaatgg cagaaccgct gatgccgtta aataccaaac gcgcagggtc ctctttgccg 2266621 ccaatcgaaa gcgaatgaac ctcgattttc ggctgatcca aagcgacagt cggacacact 2266681 tcaagcatgt gagagcccag aatcatttca tttcccggtt caaaatggta cgtgtaatct 2266741 tccatgaagg aagttctttt tcctttagcc atgattttca tcatccgtac aagggccgct 2266801 gtcttccaat ctccttcacc ggcaaaccca tagcctttct ccatcaggcg ctgaacggca 2266861 agtcccggca gctgtttcat tccgtgcagc acttcaaacg atgtcgtaaa cgctgtgtat 2266921 ccgccttgct caagaaaagc ggttaatcca agttcaattt tcgcctgttc tttaatggac 2266981 gctacctttg cttcgtcacg ttttgtttcc tcactgatca catatagtct gtcatactcg 2267041 gcataaagcg tgtcaacctc gtcgtccgta atgcgatcca tcacttcaac gagatccccg 2267101 atgccatatc cgtcaacctg ccagccaaat tgaatatgcg ctcccacctt gtctccgtcc 2267161 gttaccgcga catgacgcat gttatctcca aatctggcaa ccttaatatg tctgctttca 2267221 tttaatgcag ccgccgtatc catccactgg gacatttctt ttttcacttc ttcatcatcc 2267281 caatagccgg caatgacttt tcggctaagc cccattctcg agttgatgta accgtactct 2267341 cgatcgccat gcgcggattg gttgctgttc ataaaatcca tgtcaatcgt accccacggg 2267401 atatcgcgat tatattgggt atgcaaatgc ataagcggtt tttgataaga ggaaaggcct 2267461 tctatccaca tttttgcagg ggaaaatgtg tgcatccatg taatgatgcc agcacatgtc 2267521 tcactgtact ccgcttctct taacagctct ctaatggttt ccggtgaagt gacgacgggc 2267581 ttatgagtga ttttatatct ggaagaaatc ccgctgagcc cctcacaaat gcttttagca 2267641 tgctgatcta cgagttccag cgtctcttcc ccgtataggt gctggcttcc tgtcacaaac 2267701 cagaattcat aatcctttgt ctgaagcatg taaactgccc ctttctcata aaataaaacg 2267761 ctttcaaata caaaagatac gtactaatga tagaaaataa acctataaat aaatatttgt 2267821 acgaacaatt ttattatagt aattgactat tatactgtca atcttttctt ttaaaaaaag 2267881 ccgggggcag agcccggctt tttaattcaa taggacggcc agcccgagct ccaattcaaa 2267941 tcattgatga gaagctttgg aatgccgttg tcattggcat cataggcatg gcgaacaaga 2268001 atgtttccgt tcacaatatc ctggcctcca ggtcctttcc attggtcatt gcccgaatcc 2268061 aaaatggtgc ctccgccttc aagcatgctt tttccgcttt tatcaagata agggcctgta 2268121 atgcttttgg atcttccgta agcaattttg tacgtactgt ttaccccgtc acagcattta 2268181 tcaaatgaaa ccattaaata gtaatatcca ttttgatacg taagagtagg agcttctaag 2268241 gcacctccat tattcggtct agctgcaatc gaatagagcg agcctgtagg cttcattgta 2268301 ctcttatcga gcttagtcag cttaatgccg ctccaaaacg agccgaatgc aagccacggg 2268361 ttgccatcct tatcgaatgt cagctccgga tcaatggcgt tataattatt tgagcttgtc 2268421 gaacggatca ccaagccctc gtccttccag ccccccgaac tgatgcttgt tgaagatgcc 2268481 aggccaatgg cagatgtatt gcttccaaaa gaagaaacgg aataatatag ccagtacttg 2268541 ccgttatagt attggatgtc cggcgcccac tggttttggc cataattcgg cacataattg 2268601 gaccaccacg atagcggtgt agtgaaaatg gatttttgta cggtccaatt tttagcgtct 2268661 gaagacttca aaacccgcag tccccgttct tcagtaagcc ctgttccgag cgcataccat 2268721 gagctcccct ctttaatcat agtcgggtca tgaagcagct cattggatgc accccaaaac 2268781 gctgcctctg cgggagcagc agaagtgaat atcaaacctg cagccagagc tgcactcgaa 2268841 aagtgtaaga agcgtttcca tgtttttttc tttttcaatt ttgttcaacc tcctttattt 2268901 tagaaagcgc ttacaaatta gattatttat cctcccttcc tgtcaaatcg actgcgtatc 2268961 gtatatcgtc atgttcagga aattttcggt atccccttta ttgtagtcac tatgctgtaa 2269021 tttgtacaga caaaaaaata gaatccacct caataggcgg attcttccgt atctttattg 2269081 gtacgtaatt tcgtcaaccg tttttcggtc taacttctta atgacttctg taattaactt 2269141 taccgcgttt tcataatcat cacgatgcag catggccgcg tgcgtatgaa tgtagcgggt 2269201 tgcaatggta atggacagcg caggaacgcc atttgccgtc aaatggatgg cacccgaatc 2269261 agttccgccg ccggcaatgg catcaaattg gtacggaatg ccggcttcct ccgcagtggc 2269321 tacaactgca tcgcgcaaac ctttgtgaga gaccatggat gcatcgtaaa cgataatctg 2269381 cgggcctttg cccattttgc tctgcgcttc cttctcggaa atgccaggcg tgtctcctgc 2269441 tatccctaca tcaacaccaa acgcaatatc aggctgaatg gtgtgtgcag ccgttttcgc 2269501 tcccctcagc ccgacttcct cctgcacggt tccgacgcca tacactatat ttggatgatc 2269561 tgtgttttgt aagtttctta acacatcaat agcaatcgca cagccgatgc ggttgtccca 2269621 ggcctttgcg agtaggaatt tttcattgtt catgaccgta aattcaaaat gcggaacgat 2269681 catatctccc ggaagtacac cccactccaa ggcttcttcc cggcttgaag ctccaatatc 2269741 aataaacatg tcttttattt ccactgattt ttttcttgct tcaggagaca aaatatgagg 2269801 cggcttagat ccgataaccc ctgtgatttc tccttttttt gtgacaatgg tgacgcgctg 2269861 agcaagcata acctgagccc accagccgcc aacggtttga aaacggataa agcctttatc 2269921 tgtgatttgt gtcaccataa agccgacttc atccaaatgt ccggcgatca taattttcgg 2269981 gccgttttct gcaccagttt tttttgcaat taaactgccc aggcgatctg ttgtcacctc 2270041 atcagcaaat ggttctatgt atgatttcat cacttgcctt acttctcttt cattgcccgg 2270101 tatgcctttt gcatctgtta aatctttcag catggtcaat gtttcatcta attttgccat 2270161 gttccaaacc ctccttcatc agtcctgcat tcttattata caaaacatgg cgctaaccat 2270221 acgactattt cacttgaaaa tcgggtatat gtttttacag ctttctttta gaaaaagtga 2270281 aacctttttc tatgcttttc gtattacatc agatcatcac cataagggag gtgccttcac 2270341 acaatgtttg tcatggttct aaggattatt ttgcttgcac tttttgctta ttgtatttat 2270401 gccgtggtca aatatgtcgc gaatcctaag agaaggctta agctggccca atcaaaagaa 2270461 catttttata ttattgatga acaaaacaat acccggaaga attttcagct gacgtataaa 2270521 ggcgtgcttt ttgagggaga aaagcatatt ccttccaagg atcatccgct gtttattcac 2270581 acgatctttg tctggacaga atctcctgag aagctgaaac atttctctgc aaaagatttt 2270641 gagaacattg aagaaaaagt gctggaacga tatccaaatt gtaagattga ctgggaccag 2270701 cccattaaac tcgcaaaaaa agcagaagag cgttaaacgc ttttctgctt tttataaatc 2270761 aaacgggctg tagtaaatag cgatgagaat cgcttctatt accagaagaa gcggtactcc 2270821 gtacttaaaa gaagcgtgtt tcgttttatg tctgaaggtt tgcatgccaa gccagacacc 2270881 gagcgctcca aacacgatgg ctatcagcca cagccggtct tcagaaattc tccacttgtg 2270941 ctgctgcgct ttgcgtttgt caatgcccat cacccaaaaa ccgcacagat taatcaacac 2271001 caaataagca gcaataatca tgttgcctca tcctttatat agaaaaagcc gctctgctgg 2271061 agagcggctc tatatgatta cttgtttaat tgagctttag cagcatcagc aagctgattg 2271121 aatgcagtaa gatcgtttac agcaagatca gcaagcattt tacggtttac ttcgatacca 2271181 gaaagcttaa gaccgtgcat taaacggctg taagaaaggc cgttcatgcg agcagctgcg 2271241 ttgatacgag tgatccaaag tttacggaaa tcacgttttt tctgacgacg gtcacggaaa 2271301 gcatagtttc cagatttcat gacctgctgg ttagctactt tgtataatgt atgttttgaa 2271361 ccgaaataac cttttgctaa tttaagaacc tttttacgac gcttacgtgt aacagttccg 2271421 ccttttactc ttggcattga atttccctcc taattgttcc ttatccgatt acttgatgtt 2271481 agcaagcatt tgtttgatac gtttgaagtc tcctgcgctt acaacagcac tcttgcgaag 2271541 cttacgcttt tgcttttgag atttgttggc gaataagtga cttgtgtacg cgtgagaacg 2271601 ttttaacttc ccagaacctg tctttttaaa acgtttagca gatccgcggt gagttttcat 2271661 ttttggcatg ggatttcctc cttattgctt ttcgtttttc ggtgcgagca ttaagaacat 2271721 gctgcggccg tccatttttg gttttgtttc gactgtcgca acctcagcac atgcttcgga 2271781 gaaacggtct aatacacgct gaccgatttc tttatgagtg attgcgcgtc ctttaaagcg 2271841 gatagaagct ttcactttat cgcctttttc aaggaattta atcgcattgc gcaatttcgt 2271901 gttaaagtca tgctcatcga ttgtcggact taaccgaact tcttttaagt taatgatttt 2271961 ttgattcttg cgtgcttctt tttccttttt ctgctgctca aatcggaact taccgtagtc 2272021 catgattcgg cagacaggcg gttttgcatt cgctgcaact aacacaaggt caagatttgc 2272081 gcggccggcg atttcaagtg cttcctgacg ggacttgatt ccaagctggt cgccattttg 2272141 tccgattaaa cggacctcac gtgcacggat accctcatta accaattgat ctttgctaat 2272201 aatgagccac ctccatagtt tcttcgaatt gattcacaac tcattttgaa tgcattttgc 2272261 aggcaaacaa aaagtgtggg cattataaaa cacccacact acgaacatct gtatcaataa 2272321 aaatgtacgg tcaacctgcc aactacatgc atgtgtcaat caggtgagaa gcgggtgctt 2272381 ctgcttgtga tttatattca attcaataac tattctacac aataccggat ctttagtcaa 2272441 ggacgactta tccggaacaa cttttacatt gtaacatggg ttttctatga gcgcaagaga 2272501 gaaaaagaaa atctttcatc cccacccaga atacaaagaa ccaacaattc ccccttatta 2272561 cgcaatttac aacaaaacca ccgacaggaa gaaatgtaaa acaaagttaa tctctgaccg 2272621 atataaggag cagaagggag cctgacacat gaacaaactg atacagcttg ctttattttt 2272681 cacattgatg ttaaccggtt gctcgaatag cagcacatct tccgaatcaa aagtcgaaac 2272741 cactgttaag acaacggcag catttcctca aaaggagctg gagaaagagc taaaaaaact 2272801 aaaacccgtt tcattggaca tgaagttcga gagtccactc gctaccgagt taggaaagcg 2272861 gaaggcaaaa gaggaagctg aaaagcaaag acaaatcgcc gctgagaaaa agcttgaaaa 2272921 agagcgggag gcgaaacgaa agaaacagca ggaggaaaaa gcggagagac agcgattagc 2272981 agagcagcag gctgcagaga gacagcgatt agccgaagcg gaaagacaag ctgaacttga 2273041 aagacagcgg caggcagcaa tccaaaaaga gcagaaagcg aacgctgaga aaaagcggca 2273101 atcgcaggca caacggcagc agactgaggc accctcatct aatagtcaag atccaccatc 2273161 ttcctcgagt cagacagata aaaccattca acagccagct tcagagcttc ctgatgacga 2273221 tggttatggt tatgaagaac gaaaaaagtg gcatgacgat caagtagaat ggggcattaa 2273281 acaagggtat atcgatcccg aagacgcacc ataaaataaa aaaagccaag gcattcagcc 2273341 ttggcttatc ctccgatcag ctgcacgaac acagggatga ccagaaccgt taccactcct 2273401 actacgacaa cagcaatact tgccatcgca gcttcaactt ctcccatctc aatcccgacc 2273461 gctacaccaa gtgcatgtcc ggatgttcca agagccaatc ctttagaaat cggatttttc 2273521 actttaaaca ccttcaagaa caatgctccg agcgcatata cgatgacagc gttaaagatg 2273581 accgcaaagg ctgtgatgtc gctgatgccc ccgatgcctt ttgataaagg aagcgcaatt 2273641 gccgttgtag ccgcctgcgg aagcatgctt ttcattacgg ccgaatcgag atgaatgcct 2273701 ttagcgagca gataaacaat cgtgacagag cagatagagc cggcaataat ggaggccatg 2273761 atttgccacc agtacttttt aagcttatct ctttgtttgt acaaaggaat tgcaaatgcg 2273821 atcgttgccg gttcaagaaa aaacttaatg atctctcccc cgttattata atccgcgtag 2273881 gaaaaaccgc cgatttttaa aaatgcgatc cccagcacca tggcaacaaa caaaggagtg 2273941 aaaaggaaga agcctttcgt tttcttaaat aaaaaggtgc cgatgccgaa tgcagcaagt 2274001 gatacgacaa tcccaaaata aggactcatt gtgctttcca tgtgaagaac ctcctgtttc 2274061 ccttaatggt gaacgagttc gttattgttc tgcgggcttt gcactgtttt tgttttcatg 2274121 tccgcttcgg ttttgcgttt tccgctcagc gacagaatca gctgagaaaa caatcccgta 2274181 gcccccagca aaataatcgt tgcgagcaga atgacaagaa caatttgcag gccgtattgc 2274241 tgcatcacac caagcgaatt cataacagat atacctgatg gaacaaataa aaatccgatc 2274301 agagaggtta aagacgttcc gagcgtctcc acttgttcca gtttaatgac tttcaaacat 2274361 aataggagaa ataataagac caaccctaca accgatgccg ggataggtat tgggacaata 2274421 gcggcaatca tatttgaaac cagcataatg acggcaaaaa taaatgcttg tgttaaaaac 2274481 ccgtacactt ttttagcact cattttcttc acctctttct ctttggtacc ctcattataa 2274541 ataagaattc cctgttataa agcgcttaca agataacatg ccgtatagcg ggtctgagtt 2274601 gcagaatcaa atggctgaaa tgcaaaaagc cgcccatcaa atatggagca gctttttcaa 2274661 ttccttcgca tatgtccggc tgaccggtat tttcgatccg tctttcatga tcagattata 2274721 cgttgaatta aaccatggct gaatttcttt aatatattca gtattcacga caaagctccg 2274781 atggacgcgg ataaaatcag aatccggcag ctttttctca atcacaacga gtgtatcgct 2274841 gaccgtataa gaatgatcga aggtttttac attgacatga ccatcttctg ttccggcata 2274901 gataatgtcc ttcgtatcca caatcacaat cgattccccc acagatagcg cgagcttgtg 2274961 ctggccggca tggctgtttt gctctgtttc tacaatatcc cgattgactt ttttatattt 2275021 tttcagcgtt tgctgaattc tttcttcatc gaaaggcttg gttaaataat caagagcgtc 2275081 cacctcaaac gctttgagcg catactggtc atacgctgtc gcaaacacaa tagcaggagg 2275141 atgcttcatt ttcttcaatc gctttgcgat atcaaaaccg ttttctccgg ataaatcaac 2275201 gtctaaaaac agcaaatcag gtttttgatc catcatttgg tcaaaagcgg attcgatatt 2275261 ttccgcttca ttgatttcca tttcatcatt ggtccgctta agcaagtaag ccagttcatc 2275321 ccttgccagc atctcatcat caactattaa caccctgagc atgttcttct ccctctttca 2275381 tctgttgcat tggcacttga aaggaaacct ctgtcccttt atgaacctca ctgctgatat 2275441 gcagtgcagc ctgctgtccg aataaaccga tcagccgctg atttaggtta taaagcgctg 2275501 taccggttcc ctccttagac ggaaacggtt tcttccccag ttccggcaag acgtccggcg 2275561 gaattccgcg tccgttatcc gccaccttca tatagacgga tgcatcatca gataagacac 2275621 agactgtaac cttgcatatg tcttgttttt tcggaaacgc gtgccgaagc gcgttctcga 2275681 caagcacctg caaaacaaac ggagggattt caatctgctc cagtctgctg tcgatattaa 2275741 gctcaatttt atatttcccg ggaaaacgcg cctgttctaa tgacaaatag gcgttaagat 2275801 ggttcagctc ctttgagagc ggaatcagca gctgtctcgc tccttgaagg tttgaacgaa 2275861 aataaacact gagctgcaat aggagcttac gggttttttc aacatctgta cggcataacg 2275921 cagaaatcgt gttgatcgca ttaaataaaa aatgcggatt cacctgtgct tgaagcgctt 2275981 taatttcagc atccttgaga agtttgcttt gcagctctgc ttccccaagc tcaagctgtg 2276041 tcgaaaacag catggccagc ccctcggcaa gttcctcctc tacctgactc aggcctgccg 2276101 ggcttttaaa gtacattttt aaggtgccga ttgtattgcc gttcgatgtc agcggtagga 2276161 caattgcagc gtgcaaaggg cattcagcat gcgtgcattc aatctcttcc tgcgaaatcg 2276221 ccttcataat atgccctgtt ttaatcacct ttttggacag gccggtgatc aagcttttcg 2276281 atgggatgtg gtgatccatt cccgcaccga catgcgcaag gatcttttct ttgtcagtga 2276341 gagacaccgc atctgttcct gtcagcttat ggataatagc cgctacactt ttacaggagt 2276401 tttcatttaa tccttggcgg aaaaatggaa gtgtctgatc agcaatcgta agcactcgat 2276461 gcgtttcgag agcccttgcc tgttcttcct tgcgaatgat cgcttgaata atagacagaa 2276521 aaataaaact gcctgttcca ttgatgagta tcatcggaat tccgatcatg ctgacaagct 2276581 cccaagcgtc actgaacggc tttgccatca gcaaaataat gatcatttgc agtgactcca 2276641 tgccgattcc cacaagagcg gcgatgcgcg gtgtcggcat tcgatatcgc ttcgtaaaat 2276701 acctgccgat caagcctgca agaacacccg ctaaaataga tgagacggca cagcttaagg 2276761 ccgtgctgcc accgagtgaa aaacgatgca ggcccgcaag tatgccgatc ccagccccta 2276821 caaaaggacc tccgagaagg cccccgattt ccacgcccaa aatacgggta ttcgcgatag 2276881 agcccgatgg atctatcgta aacacccagt cattgtttac aatcatattt ctttgaattt 2276941 cgatgcctgt ataattgctg atgatgctga aaagagaaaa aatagaaatt aaaatcgctt 2277001 ttcctttata gccgtcctga ttctgaagag cttgtctgaa aagtttcgta tgggcgagaa 2277061 tgaaccctaa tataacaata atccccactc tctccagcat cataatcatt aaatgaatca 2277121 ttcatgtcac ctgttctttc cgttttcatt ctagcatgtt ttcgttttgc ggctgactgt 2277181 ttttttaaaa tcgtctgaaa acatatttca caaggctttt atctattgta aaataaaaca 2277241 tgagcctttt ggcagaaaga tttgaatctg aagcagagga gaagatcatg aaagccgtat 2277301 tttttgattt agatgataca ctactttggg acgaaaaaag cgtcagaaca acatttgcag 2277361 aaacttgctt acaggcggag aaaaaatatg gccttgcccc tgaggaattc gaagcagctg 2277421 ttcgcgaagc ggcgagagaa ttgtacatgt catatgagac gtatccatat acagtgatga 2277481 tcggcattaa cccgtttgaa ggactgtggt ccaatttctc agagccaatc agtgaaggct 2277541 ttcaaaagct gaacaagatt gtgccggagt acagaagaaa tgcatggacc aacggactga 2277601 aagcgcttgg gatcgatgat cctgcatatg gcgaatactt gggagagttt tttgcggcag 2277661 agcgcagaaa gcgcccgttt gtatatgatg aaacttttgc tgtactcgat caattaaaag 2277721 gcaagtatga attattgctt ttgacaaatg gcgatcctag tctgcaaaag gagaagcttg 2277781 ccggcgtgcc tgagctcgct ccttacttca atgaaatcgt catctcgggc gcattcggca 2277841 agggcaagcc ggatgtttca atttttgaac actgccttaa gctgatgaat attgaaaaag 2277901 acgatgccat catggtcggc gataatttga atactgatat tttaggcgct tcaagagccg 2277961 gaatcaaaac cgtttggatc aaccggactg ataagaaaaa cgaaactgac gtaaagcctg 2278021 attacatcat cagcagcctt catgatttgt ttcctatatt agagaaataa aaaaagcatg 2278081 atctcttcaa tgagatcatg cttttttatt ttattttttc gcttcagcta ctgccttttt 2278141 cacaaactca tcaagtgaaa tggtttcaga gttctgttct ccgtatttac gcacgtttac 2278201 cgctccgttt tctgcttctt ggtcaccgac caccagcatg tacgggattt tttgcatttg 2278261 cgcttcacgg attttgtagc cgattttttc atcgcggctg tcgacttcaa cacgcaggcc 2278321 ttcacattgc aggcgttcct gcactttttt cgcgtagtct aaatgcacag ccggagaaac 2278381 cgggatgact tggaactgaa ccggtgcaag ccatgtcggc agcgcgcctt tgtgttcttc 2278441 gattaagaaa gcaacaaagc gttccattgt tgaaacgaca cctctgtgaa tgacaaccgg 2278501 acggtgctgc ttgccgtcct caccgatgta tgtcaggtcg aaacgttccg gcaataagaa 2278561 atcaagctga accgtagaca gtgtttcttc ttttccgatc gcagttttca cctgaacatc 2278621 aagtttaggt ccgtagaatg ccgcttcacc ttctgcttcg taatagtcgt ggccgatttc 2278681 atccattgcc tctttcagca tggattgcgc tttgttccac atttcatcgt catcaaaata 2278741 tttctctgta tcttccggat cgcggtaaga cagacggaat gtgtaatcac ttaaaccgaa 2278801 gtcttcataa acatcctgga ttaaacggac tgtacggata aactcatcct taatttgatc 2278861 cgggcgcaca aagatgtgtg catcatttaa cgtcattccg cgtacccgtt gaagtcctga 2278921 cagcgcacct gacatttcat agcggtgcat cgttccaagc tctgcaatac gaatcggaag 2278981 ctcgcggtaa ctgtgaatgt cttgtttgta aatcatcata tggtgcggac agttcatcgg 2279041 acgcaataca agtgtttcat tgtccatttc catcggaggg aacatgcctt cctgataatg 2279101 atcccagtgt cctgatgttt catacagctc tttgctgcct agcacaggtg tgtatacgtg 2279161 ctcatagccg aggctgattt ctttatcgac aatgtagcgc tcgatgacgc ggcggattgt 2279221 tgcgcctttt ggcagccaaa gcggcaggcc ttgtccgact ttttgagagt tcgcgaacag 2279281 ctttaattct ttgccaagct ttctgtggtc gcgttctttc gcttcttcta gcatacgaag 2279341 atgctcttca agatcagctt ttttgaagaa agctgtacca tatacgcgct gaagcatttg 2279401 gtttttgctg tcaccgcgcc agtatgcgcc tgcaaggctt aacagcttaa attctttgat 2279461 ttttccggtt gaaggaacat ggacgccgcg gcacaggtca aagaattcgc cttgctcata 2279521 gatcgaaacg gtttctcctt caggaatcgc atccaatagt tcaagcttca ggtcgtcgcc 2279581 gatttccgca aaacgggctt tcgcttcttc acggctgact tcttttcgaa cgatcggaag 2279641 gttcgcatta acgatttttt tcatttcttt ctcgattttc ggcagatcct ccggtgtaat 2279701 cgcttcgtcc atttctacat cgtagtaaaa accgttttcg ataaccggac cgacgccgaa 2279761 tttaacatcc ttgtagatgc gtttaatcgc ttgagccagc aagtgagccg cactgtggcg 2279821 cataatttga agaccttctt ctgagccttc tgtaatgatt tccactgtac cgtcttcatt 2279881 gatcggcgtt ctcaaatcga tttcttttcc gttcagtttt ccggctaatg actttttctt 2279941 taatcccgga ctgatggatg ccgcgatatc ttctgttgtt gttcctttcg caaactcctt 2280001 gactgctcca tcaggaaatg tgatttttac catatctgac atctttgtca ctcctttttt 2280061 tgcatataaa aaccccgccc cctatgaaag ggacgaggtt gaataaacgg aatcgtggtt 2280121 ccaccctttt ttccgcaaag ccaatacacg gcacctgcgg ctctaagctc tgtaacggga 2280181 gttcccgtca gccattactg ttccttttca agaggttcac agctgaagtt caaaggcggt 2280241 aaagcgaatg gtccttagct gggaagcttg cagccagggc ttccctctct ttgagccggt 2280301 atcattcctt cgtgtcctta tcaatacgtg tgtctttctt aatctcctat gtattataaa 2280361 ttgttcaatc caaaaaatca acacgatcgc gtttcctttt ttttaaaccg acagccttaa 2280421 atagacaggc tgccggccct catccttccg agtgcttcac cggtatttct gcatctgtaa 2280481 aagcatgcag cgggagcatt tccactctct cttgaaatac gttttgaatg gtccttgcca 2280541 tcatgtgctc gggctggtcg gtataaagca cgacttcatc aggcgcaatg gaaatcagcg 2280601 gcgcgagcaa atgagaatca atatacatag gatgatcccg gacaaatctt ctgtctatgt 2280661 atttcatttt ttcccgttcc ggcacatagc gcagctccca taatgtaaag gaaccatcat 2280721 ggacaatatg cacttttttg attcgcggct gtttggcgtc cacatagtct ctgagtgttt 2280781 gaataaagtt ttgatattcc tgttccatct tatattcatc aatcgctgct tctgtaatat 2280841 ctctcagctg cttatagtat gatccaagtc ggaaggtctg aaaggagcga atgtaaaata 2280901 ctccttcctc taaacagatc gtttggagtt catccaaaat tgattgtttc cgtgaaagct 2280961 tcagcggctc aaacggaaga tcgtctgctt caccttcaat aatactgtgt gcgagctgaa 2281021 ggatttgctg ctgttcatcc tggtccgtga aacaatacgt ttcctcaatc aatgacagca 2281081 tatgctcgtc ttctttgcat tccaaaaaaa atttgaccag aatcggctcc ataaaacgct 2281141 gaataggaaa agccggattc gctttttcaa tcccgatttt tcgtatgcct tcacggacaa 2281201 tgatattgtt ccgatcgtcc gaatgctgaa tgagatgtaa aaaagcggct gcatcatggt 2281261 catcttcaaa gattatttca agcatgtttg tcccccctta cggcatctgt tacaagtata 2281321 tgggggatgt ttttaaaata gacgtaaagg tcattggcaa atcttaattt gattcttgga 2281381 acaagttttg cattttcttt ctgaagatga acggcaatga gataaacacg atatacaaag 2281441 cgagcaccat aaagaaagcg ggcagattgc cagccaaaaa gctcgcaccc agcacattaa 2281501 gcgcaatcgt cccagggatg attcccacag ccgttgcggc aaaatacggc agcgctttga 2281561 cattggaaag gcctgccgca tagctgacga aatcaaaatt gatcggcagg attctcaaaa 2281621 gaaagatata gaaaaatccg ttatcctcca tttgcttctg tatggcttca agcctttcgt 2281681 aatgcccgtt ctttttcgcc gaaaacaaac cagccgcaaa aaacgaaaca gctgaagcgc 2281741 acatcgaacc gaataacgta taaagcgtgc cgagaagcgg gccaaacgca agtccgccag 2281801 ctattgaaat aacagacacc ggaaataaaa caagtggcct gacgatggat atcccgataa 2281861 acatcagagg tgcaaagact ccgaacgaca atacccatac cctgatttct ttcggcgata 2281921 cattcaaata cgttttattt ccccaataga gtaaaccagc acctgcaagc actgccagcc 2281981 atttgacagc cgtttttcgt ttcataccct cagttccttc ccctttgaac cacagcaatt 2282041 atggatgtcg gcggttttct ccgtcaaggc ggatcggagc agccaaatat aatatccgct 2282101 ccattaatct tgcagctttt acttcttctt tttctcccct ctgcgaatac gtaaaatgat 2282161 gcttcagctc gtcaggtgag aaattagaag aaaagaacgt tggcagctgc tgggacattc 2282221 tgtgctgaag caccgttccg atgacctcat cccttaccca gcttgtcatt gattctgctc 2282281 cgatgtcatc aagcattaat acgggtgtgg tctttaccat attgagcttc tcttccaatg 2282341 tctggtcttg cagcgaattc ttaagctctc tcacaaattc aggcacataa acaatcatgg 2282401 aggaatactc tttttccgcc agctcattgg caattgcagc gagcataaac gtttttccta 2282461 ccccaaattt cccgtataaa tataatcctt tcccttttcc cgtctcatta tagcttttca 2282521 ggaagtctgt aacatgctga aacatcgcga gtctgcttgg gtcactgata tcaacttgct 2282581 ggaacgtcgc tccaagaaga tcctgctgga tatacatgct tttcataaga gactgttgtt 2282641 tcttctgctg gtcgagcttc cgtttgactg gacattcgta atactcgata tcaatagacc 2282701 tcccattgac aacaagcttc ggatggtagc cctccaacaa attgttgcag ttttcatctt 2282761 ccgaacaata ggagcaattc ttgctttgtt cgatatattc ataaagctta tttaagctct 2282821 tttcgatcat tttttggtca atcacttctt cgttttcctt caaaaatgct tgaacatctt 2282881 gatctttcat gactttttcc ttcatttgtt caagacgttt ttggaaatcc ggcctgccgg 2282941 ttacgccctg cagggaacgg ccgattggtt ccatctattc cttcaccccg catctctgtc 2283001 tttaataggc agagtatttt ttcagttttt gcatttcttc catcatcttt ttcttctgtt 2283061 cttccaaatc ctgcggatgc agcttctgct gtccggattc tgaatcggac gctgtttcct 2283121 tttctgtcat ccaatcagga agcttttctt cacgaatcac tttttggttt cgtttcgaag 2283181 actttgtttt tccctcagcc cattcaagat actggcggtt ttcttctatt gcgagcttca 2283241 tcgcttccct gaccgttttc acctttttgc gtgcccaatg cgaagcgatt ttttggatat 2283301 agtttttcga cagcttcatg tcggttttca gcatgacata ataaattaac acatttgtga 2283361 cgcctggctc gagcttctgt tcgaacataa tttcttctat gatcttcaga tcagcttttg 2283421 acggctctgt tccgtcagca atgtcctgca gaagcttctt cggggaaatc gcctccagca 2283481 atgcaatcag cttcccatcc agagaatcct cttctgccgg ttgttcgcct tcacgcagat 2283541 gcaccggctg tgttttttcc accaaatcgg gcagctgtcc gtttctttca atttgatacc 2283601 agtcgctcgc cgcttttctt aatgcctccg tcgtaatgac gtcacgctca tcaattgcgc 2283661 tcatcacaac attttgcatt tgcaaagggt caattccgta cagataagaa agctttttga 2283721 ttgtgtcccg cacctgctgg gtcatcgctt ttctcggtat catcgtctca gaaagtcccg 2283781 ctaaaaacaa atcaaaatca aacacatcct ccgttatggt gtaggacgga gactgtccga 2283841 cagaagtata ctcggacccc tcggcaagcc ttaccgtttc ctccatatcg gatgtgagct 2283901 tccattcact cggctgcagc gattcaaacg catgattaaa cggacgcgta atgtccttcg 2283961 catcttctga aatggccggg tgcgtaaaaa attgttttaa ttgctgatat ttcgtttttc 2284021 cgaccctatt atacagaaaa acattcagca ttccgtcttc aaaaaattca tttggtctga 2284081 gcggcggaag gagttcatat ataaagaggc gctcctgccg ctcggattct ttcatatata 2284141 ctttcagcaa tccgatgccc tcgagcttcc cctgttcctg atggatcgtt tttaagttgg 2284201 actgtgtcat ccccatcagc tgtctatgtg tggactctcc gccccacaga cggttttgtt 2284261 caagctctcc ccacaatgtc atataaagag agaatgcaac agggccgatt aagggctggt 2284321 acagttgtgt aataatttgt ctgtcaatat cctgcagcat cgatctgctt ttaaccacat 2284381 acgggtctac aggcagtaca tctttccaat agtcagccat acattctcaa accttccgaa 2284441 tttgtttcta cctttcattt tacaccgttt cttatatcta tcaaatgcca attttgcaca 2284501 tgagaaaaga gctagaagaa tcctcttagc tcttttaacg ctctttcttt attaagtctt 2284561 ttaattcatc gataaagacg tttatatctt taaactgccg atagacggac gcgaaccgca 2284621 catatgcgac ttcgtcaatc ttagccagcc ggtccatgac catttctccg acgagctcac 2284681 tcttcacctc ggagcagcct tgattgcgaa gttctttttc aatatcaaag cacatgtctt 2284741 caagcgtttt gagtgaaaca ggcctttttt cacatgcttt tatgaggccg cgcagcattt 2284801 tttctctgct gaattcctca cgcacacctt cttttttcac aacgatgagc ggggtttcct 2284861 ccactttctc aaaggtcgta aaccggtagt ggcaggattc gcactcgcgt cttcggcgaa 2284921 tcgactttcc gtcatccaca ggccgtgaat caaggactcg tgttccgtta tgctggcatg 2284981 aaggacattt caataaaatc agctcccaac tatatcgttc cctgcaatgt attttcggca 2285041 gcctccgcct tttaaaaata gatgtgacag catctgtcgg gagagccgtt gttaaatttg 2285101 tttctatagc attaggtggt ttgtgaaaat ctccttctta ttttacaaaa aaaatgaaaa 2285161 aagaaaaagc tgacactctc gtttctttat aaaaataaaa ggagcataag ctaaaaagcg 2285221 cataatggct ttctagcttc agctcccttt gtgttcgcaa tttactttat agtactttcg 2285281 cttgcgcctg tttaatttgc acaggcccca ttcctcttgg tatttcaatg ttttctcttg 2285341 tatcagcatg taatgcctct gcaatgtaat cagcagcgac attaggatct aagtctccac 2285401 aagtataaac atcaatgctc gcatatccgt gctcaggaaa actgtgaatc gttaagtgtg 2285461 attcagaaat aatcacaact ccgcttacgc cttgcggtgc aaatttgtga aatgcaacct 2285521 cgcgcacctc agcacctgat tttagagcag catttacaaa cgttttttca ataaaatcca 2285581 tgtcattcag cttatcaaaa tcgcatcccc atagctcgga gataacgtga cgccccattg 2285641 tttccatagt catggacccc ccttaacaag aattaaaaag tgaaattcca acaactgggt 2285701 cggccattta ccacggggga aagttagtcc ggagaggtcc taacccttta agtaattccg 2285761 aaacagtctc aagcaagaag ttcacgaaaa atagtatact gtgtttaagt ctaatttgca 2285821 aggtgcgttt tttcagaaat atgctgttaa gggttttttc tttaaaatgt gtccatgacc 2285881 ttattttata cagcagacgg atgtttcatt cgtgccgcta catggcggat tagatcaaca 2285941 actctgcagg agtagcccca ttcgttgtca taccacgcca gcacctttac tttcctgtct 2286001 tccattacca ttgttgtaag cccgtcaatg accgctgaat gcggattcgt attataatca 2286061 gtcgaaacga gcggttcatc tgagtaatca agtacaccgt acatcgacgt tttggcagcg 2286121 cgtttaaatg cctcgtttac ttcttcagcc gtaacatccg ttttcagatc aacaacgaga 2286181 tcaaccaatg agacgttcgg aacagggaca cgcaaggcga ggccgtgaag ttttcctttc 2286241 agatgcggca gcacaagcga aagcgccttt gccgctcctg ttgttgttgg aatgatggat 2286301 tcaccgcaag cccgcgcccg gcgcaaatct ttgtgcgggt tatcaatatt tttttggtca 2286361 ttcgtatacg catgaactgt agtcatcaga ccgctctcaa tgccaaactc ttcatccagc 2286421 acttttacaa caggcgcaag gcaatttgtc gtgcatgacg catttgaaat aatgacatgg 2286481 cgctcagcgt cgaattggtc ctcatttacg cccatcacaa tggtaacgtc ttcatttttt 2286541 cccggagcgg tcaaaatcac tttttttgca cctgcttcta tatggcccat cgctttatct 2286601 ttagcattaa acttccctgt tgcttcgacg actatgtcaa tatcatattc ccgccaaggc 2286661 agctgttttg gatcacggct gtttaacaaa agcactttct ttccatttac gatcaggcta 2286721 tcttcaccag ccacaacctc tttgtcgtat ctgccgtgaa ttgtgtcata ctttattaaa 2286781 tgagccagcg tttctgcgga atagctggcg ttaatggcca ctacttgaat ttgatcgtct 2286841 aacatcgctt ttctaaaaac cattcttccg attcttccaa acccgttgat cgctactttt 2286901 accttcatgt tggacacccc ttatcaatta tgccatccta atttgttact atctaaaatt 2286961 agtataacac attaaaacaa attcgccagt acatattgat aaaaatcaac gattataacg 2287021 ctaatttatg atgcatctta tgttttcttg cacagaatat caggcgtaag aaccaaaaag 2287081 cagccagcgc tccgcactga ctgccctcat gctttatgat tcctgtttta acttatcatt 2287141 gagcacactt tcttctagca cagaaaatgt atccccgtac actctgttaa tatgattcgc 2287201 tccccaagca cacagcatat ctaaaatccc ttctaagctg cggccgtatt cgctgagctc 2287261 gtattccact ttgggaggaa cttgattata tacgattcgg ttaatgacac cgtccgcttc 2287321 cagctcgcgc agctgctgag tcagcatttt ttgcgtgata ttgggcatta ggcgttttaa 2287381 ttcacttgtg cgtttttttc cgtgcgtcag atggcataaa atgacgcatt tccatttccc 2287441 accgatcact tcaagagtcg cttcaacaga aatgttatat tttttcttct ccatacaatc 2287501 cattctcctc acaggcacca aaaagtgact atagcacttc aaagtacgta cttttatttc 2287561 ttaacgatat gtttcataat cacatttgcc ggctgatttg aatctgctct tttttattta 2287621 tatagcttac tcggcagaat ttcaatcata caacacatct tacaaaggag gaacatcatg 2287681 acttcagcca ataaaagcaa tattcctgca ctactggctt tggccgtaag tgcattcgca 2287741 atagggacaa ctgaatttat cagtgtcggc cttttgccgc tcattgctga tgacctggat 2287801 attcccgtca cgacagcagg attgaccgtt tccctttatg cgctcggcgt tacatttggg 2287861 gcacctatat taacttcatt gacctcaagc atgtcacgta agacactatt gctttggatc 2287921 atgtttattt ttattgccgg taatacgatg gcagcaaccg cttcaagcat cgggatttta 2287981 ctagcagcac gtgtgatatc ggcattttcg cacggtgtgt ttatgtcgat cggttcgaca 2288041 atcgcagcgg atattgtccc ggaggataaa agggctagcg cgatttcaat tatgtttact 2288101 ggcctcactg tggcaactgt aaccggagtt ccttttggga catttatcgg ccagcagttc 2288161 ggctggcgtt tcgcctttat ggtcattatc gccgtcggaa tcattgcttt cattacaaat 2288221 ggcattcttg taccgtccaa attacgaaaa gggacgaaaa caacgatgcg ggatcaattg 2288281 aagcttgtga caaacagccg gttattgctt ttatttgtca ttacagcgct tggatacgga 2288341 ggaacattcg ttgtgttcac gtatctgtct cccctgcttc aggaagtaac aggcttcaaa 2288401 gccgggactg ttgcagtgat tctgctcgga tacggaatag ctattgctat cggcaatatg 2288461 attggcggaa agctgtcaaa ccgaaatccg attgccgctt tattctatat gtttatcgta 2288521 caggcaatcg ttctattcgt actgacattt acagccccgt atcaagcagc agggctcatt 2288581 accattctct gtatgggatt gctggccttt atgaacgtgc ccggccttca ggtgtatgtc 2288641 gtcatgctgg ctgagcgttt tgtcccgagt gcagttgacg tcgcatccgc gatgaatatc 2288701 gctgccttta atgcagggat cgcgcttggg tcataccttg gcggtgtgat caccgattca 2288761 atcggattga ttcataccgc ttggataggc ggattaatgg tggtcggtgc agtcatttta 2288821 acaggctgga gccgcttgat ggaaaaacga gatcggcagg aagcctgaca attttaaagg 2288881 aggaaataaa catgacaaca catttacaag caaaagcaac acttcataat ggggtagaaa 2288941 tgccttggtt cggcctcggc gtgttccaag tggaagaagg atctgaactg gtaaacgcag 2289001 ttaaaactgc cattgttcac gggtaccgca gtattgatac tgcagcaatc tatggaaatg 2289061 aagctggagt cggagaaggg attcgggaag gcattgaaga agcaggcatt tcaagagagg 2289121 atctgtttat cacatcgaaa gtatggaatg cggatttagg ctacgaagaa acactcgccg 2289181 cgtttgaaac aagtctgtcc aaactcggtc tggattattt ggatctatac ctcatccact 2289241 ggcctgtaga aggaaagtat aaagaagctt ggagagcgct tgaaacgctg tataaagaag 2289301 gccgtatcaa agcgattggc gtaagcaact tccaaattca ccatcttgaa gatctgatga 2289361 cggcagctga aattaagcct atgattaacc aagtggaatt tcacccgcgc ctcacacaaa 2289421 aagagttgat aagatactgc caaaatcagg gcatccagat ggaggcttgg tcacctttaa 2289481 tgcagggaca gctgctggat caccctgtat tggctgacat cgctcaaaca tataataaat 2289541 ctgtcgcaca aattattttg cgctgggatc tgcagcatgg cattataacg attcctaaat 2289601 caacgaagga acaccgcatt aaagaaaatg caagcgtatt tgactttgaa ttaacgcagg 2289661 atgacatgaa ccgaatcgat gcactgaatg aaaacttgcg cgtcggtcct gatccggaca 2289721 actttgattt ttaatggcca aaaaacaccg ttcaatatga acggtgtttt ttgtattatg 2289781 cccagctgtt catgatttca tcaagctgcc ttttggtctc ttcaagcgtg ccgctgttat 2289841 caatgacttg atctgctctt gctgtttttt cctctaaggg catttgagag cggatacggc 2289901 tgactgcttc ttcttctgtc agctgattgc gcttcatcag acgttccagt tgaagctctt 2289961 ttgtcacact gaccacaata attttatcaa ccaatgattc caatttgctt tcgaacaata 2290021 gcgggatatc caatacaaca aatgcctccc gatttgcaac ggcttcatca cggcgattga 2290081 gcatttcctg cctgactgcg ggatgaacaa ttgcatttaa agcgagacgt ttttgttcat 2290141 ttgtaaatac cagcgctcca agcttttttc tatctatatc gccatttgag agcagtatgt 2290201 cttcaccgaa ttcgtcaatg atttgccggt aggccggcat ccctttttct accgcttgtt 2290261 ttgcaatgat atctgcatct ataactgtta ttcctttttc aatcagcata ttggctaccg 2290321 tgcttttgcc gctagctatt cctcccgtta aaccaatgac taaggtcaag agatccactc 2290381 ctttttacaa tttccagagc ccaatcgtga ttaatagaag ccccggcaaa aacgccattt 2290441 tatcgatcca tttccactta gacagaaaat ggccggcatt gattccaatt gatacaaaca 2290501 gcgagctcat gattgccacg gcgatgctca tcacaatcgg cgaaaaaccg agaatggctg 2290561 cgcctatacc tgctccaaag gcatcaatcg ataaggcaaa tcccaataag accgcctcaa 2290621 ttccgttgat cacacccgat ttgtcgatat ccgcactcat gggttttctc aaaatatgaa 2290681 tcacaattcc taatgaccga acctctagat taagcagtgt tttttcatgc aataggtatt 2290741 ctttatcttt tgccggtttg aaaaattgat acagaaccca cgcaccgatt ccaaccaata 2290801 tcaaaccgcc aagcttctcc gtcacatata caggaaaaaa cttcgtgaga aagcttccga 2290861 tcagcatgga tataaacatg acagcaccgg aacagcaggc gataaccaaa atcgctttaa 2290921 acggtatttt catttttctc aatccgtacg taaatccgac tgaaaaactg tccaagctga 2290981 cagccaacgc cagcagcagt atagaaacca tttgcatatc cgtttcttcc tttctgttgg 2291041 tgctcttgta tcagatgtga aatgcccggg attcatcaca atcatatata tgggaaagtg 2291101 aaaaatccgt gtttcgaaaa tggcatcctt aatccagagt tactgatata tgcaccgaca 2291161 gcttggacaa tgaagcatta tgctactttt ttgtctggca ctttgcgcaa aaatgcgtgc 2291221 ctcttcctcc aacgacaatt ttcgaaatca tcgttccgca atttttgcat ggctcgtctt 2291281 tttttccgta cacaaaatgc tgcagctgga acattccgat ttccccttgg gagttgatat 2291341 atgaacggac tgtgcttccg cccgcatcaa tcgcctcctg cagagtgttt ttgatttcag 2291401 cgtgaagggt tttgattgtt ttatctgata attgatttgc ttttgtctcg ggatggacac 2291461 ccgctctgaa aagagcctca tccacataaa tgttcccgag tccaactacc gttttttgat 2291521 ccagtagggc agttttgaca gcgcggtttg ttttcgcaag ccggtctttt aaatacgcac 2291581 ttgtaaattc ttctgcatcc ggctccggcc ctaactgaga aagcgggagc tcgcccgctt 2291641 cttctcccgg tttaaataag tgcatggttc caaatttccg cacatccctg taccggagct 2291701 gggttccatc cgtcatcgtg aatatgacat gcacgtgttt atcgtcaggc tcctcggctt 2291761 gatgaagacc gtattttcct tccattcgaa ggtgagaaac cataacataa tgatctaaat 2291821 gaaacagtaa aaactttccc cgtcttccga tggactgtat cgtttctcct gctagttttc 2291881 gcgcaaattc ctccggttcg gcaggccgtt tgatgatatt cggccatctg atctctaccg 2291941 atttgattgt ttttcccttt acaagcccgg tcagagtgcg ccggaccgtc tcaacctctg 2292001 gtaattccgg cacatccatc acttcctatc tctgtttatt tcgcatcgta ccaagatggg 2292061 cctgatgcaa agtccacctt taacggcaca tctaatgcaa gcgcatgctc catcacttca 2292121 ggaacaagct tttcaagaat ttcaatttct tcctttggcg cctcaaaaat caattcatcg 2292181 tgtacttgaa gcagaagcct tgctttcaac tgtttttctt tcagcttggc agccatgtca 2292241 atcatggctt ttttgataat atcagcggcg cttccttgaa tcggcgtatt catggccgtc 2292301 cgctccgcaa aacttcggat attaaagttc cggctcgtca gctcagggat gtagcggcgg 2292361 cgatgcataa gcgttgttac gtatcctttt tgtttcgctt cctgtactga atcttccatg 2292421 tacgctttta cgccttggaa gctttccaga tagcggtcga taaatgctcc cgcttccttc 2292481 cgggtaatgc cgaggttctg tgacagaccg taatcgctga tcccgtaaac aatgccaaag 2292541 ttgaccgctt tcgcctggcg tctcatcgca gatgtcactt catccttagc gacatggaac 2292601 acatccattg ccgttttcgt gtgaatatcc atatcattag taaaagcttc gatcagattt 2292661 tcatcctttg aaatatgggc aagcacccgc agctcgattt gtgaataatc ggctgcaaaa 2292721 atgagccagt ctttttcaga cggcacaaaa gcttggcgaa ttttccgccc ttcctcaagc 2292781 ctgatcggaa tgttttgcag gttcggatca gtcgagctga gacggccagt ttgcgttaag 2292841 gcctggttaa atcgcgtgtg cactttatgc gaatccggtc tcgtcacctt taaaagccct 2292901 tcgatatatg ttgattgaag cttgccaatt tgtctgtact gtaaaatata gtcgacaata 2292961 tcatgcttgt cagccagctt ttcaagcaca tcggcagacg tagaatagcc tgttttcgtt 2293021 ttctttacga caggaaggcc gatcttttca aataagatga cgcctagctg tttcggagaa 2293081 ttgatgttaa acggctctcc cgcaatctca tggatttttt cttcatattc cttcagcttc 2293141 gcacccagtt cttcacccat ccgttttaaa cggtcaacat cgaccttgac gccagttgat 2293201 tccatttcgc caagaataag cgcaagaggc atttccagct cttcaaacag ttcaagctgg 2293261 tcgttgtttt ccagctcttg aacgagcttt tcccgaaggc tttgaatcgc taacgctttt 2293321 cggccaaggt gctcagacag tacgtcttct gacggcactg cccgttttgc tccttttcca 2293381 taaactgatt catcacttga aacgatatgc aggccgtaat ccttagccac actcgcaacg 2293441 tcgtcatatg aattgcccgg gttgatgata taagccgcaa ggagcgtatc aaactcggct 2293501 cctttcagct caatgccctg ccagcgcaaa gcgacaacgg cccgcttgct gtcgaagacc 2293561 catttcttct gctcgtcatt ttccacccat tctttaaaca cctcagactc aacggcaatg 2293621 tctttcggaa tgaaataagc tcccgtttca tttacgatcg aaaatccgag gatcggctct 2293681 tcatgataat tatcgccaat ctgttcaacg acaaatgcgg atggagaaac caatatatcg 2293741 cttgtcacgt ctgtgactgt tttgacatta atgtcttcca acgattgatc ctgttctgct 2293801 tctgcactgt cttctccaag ccgttcaaga agcgtgttga agccaagatc tttaaagatg 2293861 gcaatgacct gttcacgatt aaagccttga tattccaggc cggaaacaga tacctcaatc 2293921 ggagcatccg tcataattgt cgcaagctcc ttgctcatca atgcctgatc cttaaactcc 2293981 tcaagctttt ccttcaattt ctttccgctc acctcgtcaa tggactccag cagcttttca 2294041 acggaatcaa attgttttaa aagcttaatc gcagtctttt ctccgacgcc gggcacaccc 2294101 ggaatattat ctgaggaatc gcccatcaga cccttcatgt caatgatttg ttcaggcgta 2294161 agcccatatt tctctttgac atgctccggt gtgtaaaatt caacatcggt aattcccttt 2294221 ctcgtaatgg caactgtcgt tttgtccgtt gccagctggg ttaaatcctt atctcctgag 2294281 aaaaccttaa cttcaaatcc gtctttttca gccgatttgg ccagtgtgcc gataatatca 2294341 tccgcttcat attgttccag ttcatagcgg ctgatctggt aggcatccag cagctcgcgg 2294401 ataaacggca tttgttcgga aagctcaggc ggggttttct gtctgccgcc tttatattct 2294461 ttaaatgtgc cgtgacgaaa tgttgttttc ccggcatcaa acgcaaccag catgtgcgtc 2294521 ggtttttcat cctcaagcat tttcatcaaa atcatcgcaa agccgtatac agcattcgta 2294581 tgaacacctt tatcattgct taacagcggc aatgcaaaaa acgcccggta agccagactg 2294641 tttccgtcta caagcactaa tttttttcgt tccgtcattc aatttcctcc taagaagcct 2294701 caggcttcca ttcatctctt acatagtcat tagctcctct tattttaaca aagttcaatt 2294761 tgaaaggaaa atacgtgaac tataagagaa gacacaaaaa aggacgggaa cacaaatagg 2294821 ttcccgccgt caaaattggc tccttggatg aaggggttct actacatcct accagcatag 2294881 gtttaacagt gcatgaagat attgttaaac ctttgtaaac attaggcgga cttttcagcg 2294941 gcccgtttca gcgtcacggt aaagacagtt ccccgtccaa gctcgcttgt gacatcaatt 2295001 ttcccttcat gagcctctat taaatgcttg acaatcgcta ggcccagccc ggttccgccc 2295061 gaatttctgc ttctgtcttt atctacacgg taaaagcgtt caaagatgcg cggaatttct 2295121 tctttctgaa ttccgattcc agaatcggca acctcaatct gaatgtcttt ttctctgggc 2295181 tttacattga tagccacgga gcccccctca ggcgtgtagg ttaatgcatt gtttacgaga 2295241 ttaagaaata cctgtttcag cctgtacggg tcaccagata catattgagg gtctttcggg 2295301 acattcaggt gcaaggagat gcctttctca tccgccttat gcttcagaag cgtttcaatc 2295361 tcaccaagca ttttggccgg ctcaaacgtt tcgatactga gcgtgaaatt ttgctgctcg 2295421 atttttgaga gatcgagcaa atcctgaacc aaagactgaa gcctttcgct ttccttaaga 2295481 ataatagaga gaaattcaga aagcgcctct ttgtcttcca tcgccccgtc caataacgtc 2295541 tccgtaaacc cttttatgga cgtaatcggt gttttcagct catgagaaac attggccaca 2295601 aaatccttcc tcatctgctc taatttcttc gtttccgtca tgtcatggaa aacgagcaca 2295661 attcctttcc attcatcgtc cggccccata atcggaacgc cgtccacttc aaaataacgc 2295721 cgttctattt tgatcggcag tcttaacagc ttgcatttct ttgtctccgt cataaaaatg 2295781 tcttcgacaa gctggatcac ttcttcatgt tcaaatgcat cgtgataaag acggcgcagc 2295841 atatgattcg gattgatatg aaactgcttg gcgtaagacc tgtttacgag attaataaag 2295901 cctcttccgt cgatcataat cagcccggag ccaatgtttt caatgactgt cagcagccga 2295961 tcccgctgca tttcctgcgt tcgcgtcatt tccatcagat caatggcaag gctgttcatc 2296021 gcatgtccta gcttatcaga acgcctaata tagccgccgt acgtccgtgc atcgtagttg 2296081 cccttagaga gttctgtggc tacatttgtc gctgactcaa ttgacctttt ataacgtgag 2296141 gtcatgctgg aataaaaata aacaatgacg ataaatgcgg tacaaagact ggccgtcagc 2296201 atcccccaca attcgccttt taagccgtcg cttttttcag aggcggaaag cagcacatat 2296261 cctgtttttt caccttcgct tctaagtgaa agtccgtaat aaagcttgtt atctgttgtt 2296321 gacagaatac cctcatggcc agaaacaagc gcctgcacct tttgggaatc agccgatcta 2296381 ccgtttgacc catacagcac cttaccgtct gtatcgataa cggatgcgct cacatcaagc 2296441 gcgccgcctg catctttaat gattttctca tttgcttgat tattcagatt gccggcatca 2296501 agaagcgaag ccaagtattt tgcttctttt tcaatgtgtt cctctgcttt cctttgatca 2296561 gatgtttcaa aaagctgctg taaaaacagc ccgaggacac aaaacaccag aatcatacag 2296621 acaacgaata cagaaaaaag gcgcacacgg tatttattca ttcatttttg gctcctccag 2296681 tttatacccc aatcccctaa tcgttttaat gtagatcggt tttttggtat tgttttcaat 2296741 tttgtcgcga agatggctga tgtgcacatc aacaattctc gtatctccgg caaaatcata 2296801 attccagact gcgctcagca gcaggtctct tgtcagaact ctgcctttat gtctgcctaa 2296861 atagagcagc agttcgaatt ctttcggtgt cagttcaagc tgactttctt taaagtacgc 2296921 ttcataatga tcaggcagga ttttcagatc gccgattacg atctggcctt ccatttcatc 2296981 gttcttcatc tcactagagg gcgcagctat ttccgaacgc cttaaaatcg ctttgactct 2297041 cgcatttact tcccttggac tgaacggctt ggtcatataa tcatcagcac cgagctccag 2297101 ccctaatact ttgtcgaatt cctcatcctt cgctgtcagc attaaaatgg gaaacatcag 2297161 tttttgctgt ctcagctgct tgcatacttc gattccgtcc aattttggaa gcatcacatc 2297221 aagcacaatc aaatcaggtt tctctgtttc cgcttttttg agtgcttctt ccccatccga 2297281 ggcggtaatg acatcatagc ctgaccgttc caaattgtac tgtaaaagag taacaataga 2297341 ttcttcatca tccacaacta aaattttctt gttcatgctg tgcctccagt attataattc 2297401 cccgacatcc tatttctcta ttttatgtca tcttaacatg tttcatgatt ttattttagc 2297461 gaaagcagga cattccgaca attcgccttt tacatcattt ttaaaagaaa taaagacgtt 2297521 tatgatagcg ctttcattta tagtaaaaag agaaaggctg tattaagcaa gcctttctct 2297581 ctttttatta ggataatact ttcatgacat ttttgacaga ttcaactgat ttattcagct 2297641 gcgctctttc atagtctgtc agttcaagtt caatgatttg ctcaagaccg ttgccgccta 2297701 caattgtagg aacaccaagg tagatgcctt catagccgta ttccccttca agataagcaa 2297761 ttgtaggaag gacgcggcgc tgatctttca agatcgcttc gaccatttct gtcagagaag 2297821 ccgcaggcgc ataatacgcg cttccgtttc caagaagatt cacgatttcg cctccgcctt 2297881 ttctagtgcg ctccacaatt gcgtcaatcc gttctttcgg aataagagtt tcaagcggga 2297941 taccgccagc ataagaataa cgcacaagcg gaaccatatc gtcaccgtgt ccgccgagta 2298001 cgaaaccagt cacatctttc actgacaggt ttaattcctc tgccacaaat gttctgaatc 2298061 ttgccgtatc aagcacacct gactggccga ttacacgctc tttagggaag cctgattctt 2298121 tgtacaccgc gtatgtcatt gcatcaacag gatttgtcag caccacaata atagagtcag 2298181 gagaatattt cacgatttcc tgcgtaacgc ttctcataat cttttcgttt gtagagacca 2298241 gatcatctct gctcatacca ggttttcttg cgataccggc tgtaatgaca acaatgtcag 2298301 agccggctgt atcctcgtaa ttggatgttc ccgtaatttt tgcgtcaaag ccttgaaccg 2298361 ggcttgcttc aagcatatca agcgcttttc cctttgtcgg gttctccaat tgcggaatgt 2298421 caacaagaac aacgtctgcc agctcttttt gagcgattaa aaatgcagtt gtagctccgg 2298481 taaaacctgc tccgataaca gaaacttttt tacgagtatt tcccatgtct ctcttctcct 2298541 ttatggctag ttttaggctt tttccttgct tagtccatgt ttttgatcag ttcttctccg 2298601 aactctgaac atttcacttc agtcgccccg tccattaatc tggcaaaatc gtaagttacg 2298661 actttagaag cgattgtttt ttccatagat ttgataacca aatcagccgc ttcgttccat 2298721 cctaaatgct caagaagcag aacgcctgaa agaataactg aagatgggtt tactttatca 2298781 aggcctgcat atttaggagc cgttccgtgc gtcgcctcga aaatcgcatg tcctgtttcg 2298841 tagttgatgt tcgctccagg agcaatgccg attccgccga cttgcgcagc aagagcatca 2298901 gaaatgtaat ctccgttcaa gttcattgtc gcaacgacat caaactcgtt tggacgcgtt 2298961 aagatctgct gaaggaaaat gtcagcaatg ctgtctttga taatgatttt tcctgctgct 2299021 tccgcttcgc tttgcgcttt gttggcagcg tcttttcctt gttcttcagc aatgcggtca 2299081 tattgagccc atgtgaagac tttatctccg tattcttttt cagcaagttc atagccccag 2299141 tttttgaagg cgccttctgt gaacttcatg atgtttcctt tgtgaacaag tgttacagat 2299201 ttgcggccat gctcgatcgc ataatcaatg gcagctctga ccaagcggct tgttccttct 2299261 tctgaaacag gcttaatgcc gatacctgat gtctcaggga aacggatttt attgacgttt 2299321 aactcatttt gaaggaagct gataagcttt tgcacttctt cagagccttt tgcatactcg 2299381 atgcctgcgt aaatatcttc tgtattttca cggaagatga ccatatcagt atcttcaggg 2299441 cgttttaccg gtgacggcac tccagtaaag tatcttacag gtcttaagca gacgaatagg 2299501 tcaagctctt gtctgagcgc tacgttcaaa gaacggatac cgccgccgac aggtgtcgtt 2299561 aacgggcctt taatcgcgat gaaatattcg cggatcacat ctaatgtttc agcagggagc 2299621 cactcacctg ttttattata agccttttct ccggcgtaaa cttctttcca tgtaattttc 2299681 ttttcgcctt tgtatgcttt ttctactgct gcttccaaaa ccttcgaagc cgcgttccaa 2299741 atatcaggac cggttccgtc tccttcgata aatgggataa tcgggttgtt tggtacgttt 2299801 aatactccgt tagagactgt aattttttca ccttgtgcca caataaaaac ctcccagtat 2299861 gtaattcata tttagaaaac attttatttt tcttatatag aaaataaaat gatttttcct 2299921 aacattcaat ttaaagtgta acccaatttt gatgtctgaa caagaggcta acctcattga 2299981 cgcaagccag cctccaatgg ttctttaggc tctttcttca atcggaacga atttttgttt 2300041 gtcagggcct gtgtaatctg cccgcgggcg gatcagacgg ttgttgtcat actgctcaag 2300101 aatatgagcg agccagccgg acattctgct tacagcaaaa atcggtgtaa acaaatcatg 2300161 gtcaataccg aggctgtgat atacagaagc cgaatagaaa tcaacgttag gcggaagctt 2300221 tttctctgat gtgacgatgt cttctatacg aatcgacatc tcataccatt tgctttcgcc 2300281 tgtcaggttg gtcaggcgct tgctcatttc tttcagatgc ttcgcgcgcg gatcaccatg 2300341 cttatacaca cggtggccga atcccatgat tttttctttc ttttcaagtt tagcgcggat 2300401 gtacggctca gcgttttcca cttcaccgat ttctgtcagc attttcataa cgccttcatt 2300461 cgctccgccg tgaagaggcc ctttcagcgc gccgattgct gcagtaatgc ctgaatagat 2300521 gtcagaaagt gttgcgacgc agaccctcgc tgtgaacgtt gacgcgttca gctcatggtc 2300581 agcatgtaaa atcaatgctt tgttgaaggc ttcaacttca attggtgaag gctcttcacc 2300641 gtttaatgtg taaagaaaat tctccgcaat accgtaatct tctctcggtt caacaggctc 2300701 aagacccttg cgaattctgg aaaacgctgc aaccaggcca ggcacctttg cctgaaggcg 2300761 gatcgccttt ctgtagttgg cttccgggtt catggtatca gcctcgctgt caagcaggcc 2300821 tagtaatgaa attgctgtcc gaagagcagc catgggatga acattttcga gggaataaga 2300881 tttgaagtgc tcaataattt cttgcggaac ggcagcttcc tttgcaagct gctgctttaa 2300941 ctcttcaagc tcttttttgt ttggcagcct tagatgccaa agcaagtaga tgatttcttc 2301001 aaaacttgca ttctctgtca aatcatcgat atcatacccc acatatgtaa gggtatcatc 2301061 aataatagaa ctaacagatg atgttgttgc tacaacccct tcaagaccgc gtgtcgctgt 2301121 catatataac atctcctttt caataaattt cccctttaag agtgttgtaa aaacatgagg 2301181 cttacttaaa aagcacgatg caagtatttc tctcccccaa aaagaaaatg cttacatttt 2301241 actggctgct ggaactaaaa ccctttgctt ttgaaagaac ataacaaatt tttataagct 2301301 tatttaagtt taagcctatt ctcattataa acaataatca gacatttgtt aaatgtttac 2301361 ctataatttt ttttttccat tctgtgattt ccccgaaaaa acgcctttat ttgcgggttt 2301421 ttgcataaaa aaaagcggct ttaaggccgc ttttttttat gaagtgaaca gttttacgat 2301481 ctgcatggct aaataagcaa tccccgctcc gatcagcggc cccaccgcaa ctcctccaaa 2301541 aagcgcgact gcaagaatgg tcccgatcac gagagcagtt gtaatatgcg gatcattttc 2301601 aagcagggtc aggccgtttt ttgcaatcag cgccactgcg atccccgctc caagggcgat 2301661 ccatgcgtag gaagaccgca ttgcttctcc aagctgctta aatccgattt ctcccgtggc 2301721 aatcgggaca agaacggcga tggtaataat ggtcacaccc cagttaatgc cttttgactg 2301781 gatggtcgga aataatttct gatcaagccc aacgattttg atgatcaaaa ggacggatac 2301841 agcaaagagc aatgattggt tttttgcgat aagtgcgata gccaagagta aaattaaaaa 2301901 taaattcgct tgtgtaaaca catgccatcc ctcctttaag atgaatgtat tcatattcag 2301961 ccgcagcgtg aatacatata aaaaatagga catgctgacg agaggaggac cgtttttgtg 2302021 aatcaatctt atatcactat ttttttcaga accctctttg tcatatcaat gaccgcaggg 2302081 tcgatagctg cggcctatta ttcgtttccg ttaacttatc cgttcctgat cgcccttatt 2302141 ctatcttcag tgattcatcc tgttgtcgat tatttggaca aagtgacagg attcccccga 2302201 acgataaatg ttctgggcgt tcttgctttt tttctgctcg cagccttcgg cgtgctcacc 2302261 attctggtag ccgaaatcgt aacgggaaca gcctatctag caaaaacgct gcctccgcat 2302321 atcagcacgt ttatttcata ttgcgaaaaa ttgtttacca ctcatattca gccgctctat 2302381 aacgagttaa ctcttttgtt tcaagaattg gaaacgaacc agcaggcttc catcgtcact 2302441 catatccaga cactcggtga ttctgccgct aaaaatgccg ggctcctgct gtcccacatt 2302501 ctagagatga tcccgagatt tttcgctctt cttcccaata cggcggcggt tctgattttt 2302561 tctcttctgg caaccttttt tatgacaaag gattggcata agctgaaagc catgcttgtt 2302621 ttaattctgc cggatcgtgt gacagctaac agcaaagcaa tcagcagcga attaaaaaaa 2302681 gcaatgactg gttttatcaa agcacaagcc gtcctcgttt tcatcacgat ggtgattgta 2302741 tttatcggcc tttctctctt aaaggttgaa cacgccgcaa caattgcttt tttaatcggg 2302801 cttgtagatc ttctccctta cttaggtgcc ggctccgtat ttgtgccctg gattttgtat 2302861 ttatcgatta cgggccagct gccccaagca atcggaattg gtatcctgta cctcgtcgtt 2302921 cttattcagc ggcagctgac agagcccaag atactaagta aatctatcgg gatcgatccg 2302981 ctggcaacac tcatcgccct gtttgccggc tttaaattat tcgggttttt aggactgatt 2303041 gcgggaccgg ctgtactcgt catcatccaa gctttcatca caacaggcgc attaaaagaa 2303101 atatggtcct atatcaccgt tcagcaaaaa taaaacggca gccgtttttt catggctgcc 2303161 gttttttatt tgatgatgat ccgcttattc ttcgacattc ctctcagcca tttgaacaga 2303221 atcggcttac accagccgcg ggtaaacggg ataagaagac aggcgccggc caaatctgat 2303281 aaaaagcccg gaagcatcag caatagaccg ccaatgaaaa tgcacagacc gtcagcaatc 2303341 gcttctcccg gcattttgcc atattgaaga tcacgctgaa ccttataata cacttcggtt 2303401 ccttgttttt ttgcagctgc tgcgccgata atgccagtca gaatcatgaa tagaactgtc 2303461 ggcaaaatac caatcagatt tcctaaaaat aggaatatac cgatttctat tgccggaaac 2303521 acaataaaaa gcaaaaacaa aaatctcata tccaagcccc ccacacgtgt aacacgttct 2303581 gttcaacaaa aggcatgata aagagaaaag gaagggattc cccttccatt ttcacctgta 2303641 attaaagaac gctcgcacgg ccttgataga ctgcgcctct ggaagcgtca actgtaatat 2303701 cctggccatc tgtcaaaata gatgtcgcat tttccagacc cacgataacc gggatgccaa 2303761 ggcttaatcc gactaccgca gcatggctag tcaaaccgcc ttcttctgta ataagagcag 2303821 acgctttttc aagggatgca atcatatcac ggtcagtgct tttggtaaca agtaccgcac 2303881 cgtcagtcat tttttgctca gcttcttttg cattttgtgc aacgacaacc ggaccgtaag 2303941 ctgatttgcg tccaatgcct tggcctttag cgatgatatc gccgacagta tgaaccttca 2304001 ttaagttcgt agtgccggac tcaccgacag tgccagctgt aataacgata agatcgccgt 2304061 gttttacaat tccgctgttc aatgattttt ggacagcatc ctcaagcatc tcatctgttg 2304121 agctcgcatt ttggccgctt tccgcgaata cgccagatac gagggcaagc tttctggaaa 2304181 tagagtcatt tacagtaacc gcaacaatcg gagcctgcgg acggtatttt gcaatcatac 2304241 gtgctgtatg gccgctttct gtcggcgtta cgatcgcagc agcattcagg ttaatcgccg 2304301 tatgtgcgac agattgtcca attgcgtctg taattgtcat gcccacttgg tctctgcgtt 2304361 ttgagagaat ttctttataa tttaatgctt cttcagaacg ggacgcgatg ttatgcattg 2304421 tttgaactgc ttcaaccggg taacttccgg cagcagtttc accagaaagc atgatcgcat 2304481 ctgttccgtc gaagatcgcg tttgcaacgt cacttgcttc cgcacgagtc ggacgcgggt 2304541 tgcgctgcat gctgtcaagc atttgtgtcg ctgtaataac aggtttgccc agcgcgttgc 2304601 attttttgat cagttctttt tgcacaagcg gcacttcttc agctggaatt tccacaccta 2304661 agtctccgcg tgcaaccatt aagccgtcag acacttcgag aatcgcatcg atgttgtcaa 2304721 cgccctcttg gttttcgatt ttagggatga tttgaatatc ctgagcgttg tgctcttcaa 2304781 gaagctcacg gatttcgagc acatccgtag aacgtcgaat gaaagatggt gcgatgaagt 2304841 ctactccttg ctcaataccg aaaacgatgt ctcgcgcatc cttttcagta atccccggaa 2304901 gattgacact tacgcccggt acgttaacac cttttttatt tttgagtgtt ccgttgttta 2304961 atacttttgt tttgatttcg cgtttagcgg catctacatc aagtacctca agaccgataa 2305021 ggccgtcatc taacagaatc gttgaacctt gttcaacgtc atggactaaa ccttcatatg 2305081 tcactgaaat tttatctgtt gttcctacaa cctcgtccat tgaaataatg agctctttgc 2305141 ctgtttcaag ctcaataccg ccgttttcca ttgtatgtgt gcggatttca ggaccttttg 2305201 tatcaagcag aattccaacg ttcttgccaa gttttttact tgcttcgcgg atatttttaa 2305261 ttcttgcacc gtgctcctca aaatctccgt gagaaaagtt taatcgagcc acgttcattc 2305321 ctgactccat taatttcgta agcatttcaa tactttcact tgccggaccg atggtacaaa 2305381 caattttagt ttttctcatt tggttcactt ccttctgaaa tcttcagcct tcagctgtac 2305441 attagataga cagttctttt gaaagctgat acatgttttg ctcaactgtg tgttttgtct 2305501 caagtatttc tataatatca tggtctacaa gcttattgtt ttgtatacct acacagcgtc 2305561 cgccttttcc ttcaagcagc agttcaactg catatgcgcc gagacggctt gccaacacac 2305621 ggtcagcagc actcggagaa cctccgcgct ggatatggcc caatacagat accctagttt 2305681 caagatttgt ttcttcttca atgcgtttcc cgaattcaac accgctgcct acaccttcgg 2305741 caacaataat aatactgtgc ttcttgccgc gttcgtggcc gcgttttaag cgggcaatga 2305801 tttcgtgcat gtcatagtct gcctcaggga ttaagatcga ttctgcgccc cctgcaagac 2305861 cggcccacaa tgcgatatcg ccggcatgac ggcccattac ttcgattaca tatgtacgtt 2305921 catgagaagt cgctgtatcg cgaatcttat caattgcgtc aattactgta tttaaagctg 2305981 tatcgaaacc gattgtaaaa tcagtgcccg gaatgtcatt atcaattgta cccggtacac 2306041 ctacacatgg aaacccgtgt tccgttaatt ttttcgcacc catataggaa ccgtctccac 2306101 cgataacaac aaggccttca ataccaagct tcttcaagtt tgctatccct ttttcacggc 2306161 cttcaactgt tttgaattca ggacatctcg ccgtataaag cttagtccct ccacgatgta 2306221 taatatcgcc tactgatccg agttcaagct tttcaatctt tccgctgatc aatcccgcgt 2306281 atccgttgta aataccgtaa acttcaacgt catgatagat cgcttttctg actactgcgc 2306341 gaactgctgc gttcattccc ggggaatccc cgccgctcgt taatacccct attcgtttca 2306401 ttctccattc acctcagcaa catatatgat taaacataac atgatcattg ccctaaaaac 2306461 aatgaaaagg gatctccatc ctccctatga aaccttacct attatacaat taaataaatt 2306521 gtttttaaat aaaatttaag gaatgtcaca aaaaataaac gtgagccaaa ggcttcacgt 2306581 ttatttagtt taccccgata tattgatctt caaccgagac tttgccaatt gctttatatt 2306641 tttcataacg ctgctgaact aattcttctt cgctcagctt cagtaaagtt tttaacgatt 2306701 gtttaagggt ttcgtccata tagcttgcct gcagcttcac atcatggtgc gctccgcctt 2306761 ttacttcttt aatcatatga tctataatac ctaattcttt taaatccggc gcagtgattt 2306821 tcattgtttc tgctgctttt ttagcaagac tggagtcctt ccataaaagt gccgcggcac 2306881 cttccggaga aataacagaa taagtagagt tttccagcat atgcaagtga ttgcctacac 2306941 ccagaccaag ggctccgccg cttccgcctt caccaatgac gatgcagata acaggcactc 2307001 gaaggccggc catctcaaac aggtttttgg caatagcttc actttgtcct ctttcttcag 2307061 ctgctcgtcc agggtatgcc cccttcgtat caataaaaca gataattggt ctgttaaatt 2307121 tgtcagcctg tttcatcaga cgaagcgctt ttctgtagcc ttctggatgc ggcatcccaa 2307181 aattgcggac taggttttcc ttcgtgtctt tgccgcgctg atgcccgatt accgttacag 2307241 ggaggccgtg gaacttcgca atcccgccga caatggcttc atcgtccccg tacgctctgt 2307301 ctccgtgaca ttcaaaaaag tcggtaaaca ggtgttcgat ataatcaaga gttgtcggac 2307361 ggtccgccag acgcgcgatt tgaacccggt cccacggctt caaatttttg taaatatcat 2307421 cctgaagctt agcgagacgg tcttcgagcc gttcgatttc cgcacttaga tccatatcgg 2307481 aatcttgggt gaattttttt agttcggcga ttttggtttg cagttcaatc accggttttt 2307541 caaattctaa tcttggagcc actcaatgtc acctcctgtt tgatgcatat ccagcagatt 2307601 ttctaacgtt tttttcatat cgtcgcgatg aataaccgca tcaagctgtc catgttttaa 2307661 taaaaactca gccgtttgga agtcctcagg cagtttttct cctattgtct gttcaataat 2307721 ccgtcttccg gcaaaaccga tcagcgcgcc aggctcagcg aaattgtaat cgccaaggga 2307781 tgcaaagctt gctgatacgc ccccggtagt cggatgcgtc attactgaaa taataagacc 2307841 ctgttcttca ctgaacagtt ttaacgcaga gcttgtcttt gccatctgca tcaaacttaa 2307901 tacgccttcc tgcattctag caccgcctga agccgtaaaa ataataaacg gaactttatc 2307961 agcttttgct ttttcaatcg caagcgtgat tttttcaccg acgactgaac ccatgctgcc 2308021 cattctgaat gaagagtcca tgacggcgac aacagccggg tgtccgccga tggtgccctt 2308081 gcctgtcaca acagcctcgt ttaaggatgt tttctcgcga tctttttcaa gcttttccag 2308141 atatcccggg aaaccaagcg gattttccga gagcattccc tgattaaatt cctcaaagga 2308201 ttgttcatcc atcaagcttt cgatacgctg ttttgcgttc attgggaaat gataatcgca 2308261 gttcatgcat acccgcatat ttttatccaa ctctttagtg agcatgattt ttttacactt 2308321 aggacatttt gtcataatgc cttccggaac atcgtgcttc gcttgatcag acggtacgga 2308381 agcatacttt ttctttttcg tgaatatatc ctttaacaaa tgattacctc ccttttgtga 2308441 agggttctct tcaccgcatg tcatcaaaca gatagacttg ctaataactt taccgaaact 2308501 attgtacttt ttttgtcaaa cgctgtcatc ctcaattcga caacttttta ttcgatgacg 2308561 tgctcggaaa ggcttgtatg aaatcagata aggtgttgaa acgacaaggt tgacagcgca 2308621 ttcaaaaata atgttaaacc cggctgaaat ttttttaagg ctaaccccct aaaaaaattt 2308681 cagccgtcag tttaacttga gaacagcgcg ccggtctccg ccaacgcgct gccatttttg 2308741 gaatgaatta aaattattca ccaataatcg taagttttct tgttttttct gcgacttcct 2308801 cagggtcaac agtgattctt gcaacacctg tttccatcgc agcttttgcc acagccttcg 2308861 caacagcagg cgcaacacgt ttatcaaacg gtgcagggat gacatagtct gcgctaagct 2308921 catcttctga aaccagtgaa gcaatggctt caaccgctgc gattttcatt tcctcgttaa 2308981 tatgagtggc acgcacatca agcgctccgc ggaaaatacc agggaatgca agaacattgt 2309041 ttacttggtt cgggaagtca gaacggccag ttccgacaac gcttgctccg gcttcacgcg 2309101 catcttccgg catgatttcc ggatttggat ttgccattgc aaagataatc ggatcttttg 2309161 ccatgctttg aaccatttct tttgttaacg cgcctgctac agagacaccg ataaatacgt 2309221 cagcatcaac gataacatct ttcagagaac cgtctttgcg atcttggttc gtgaacttcg 2309281 ccacttcatt tttgacatcg ttcatgccgt tcgggcgccc ttcataaatg gcccctttgg 2309341 aatcgcacat cacaatgtcg cgaacgccat aatgatgaag aagcttgata atcgcaatgc 2309401 cagccgcacc cgcgccgttt gcgacaactt taatggatga catggatttt ccagacagtt 2309461 tcagcgcgtt cacaagacct gctacggtta caatggcagt accgtgctga tcatcatgga 2309521 aaaccgggat gtttgtttct tttttgaggc gctcttcaat gataaagcag tttggcgctg 2309581 caatatcttc aaggttgacg ccgccaaatg tcggttccag caattttaca gtttcaacga 2309641 ttttatcaac atcgtttgtg tttaaagcaa tcgggaacgc atctacgccc gcaaagcttt 2309701 tgaaaagaac tgctttccct tccataacag gaagcgccgc ttcagggccg atgtttccaa 2309761 ggccaagcac agctgtaccg tcagttacaa ctgctaccat gttccccttc attgtataat 2309821 catatacttt gttaatgtct tcatgaatat ccttacacgg ttctgcaaca cccggagaat 2309881 acgcgaggct taaatctttc gcatttctga cctctacttt tgatttagac tccagtttcc 2309941 cctggttgac tttatgcagg tgtaatgctt cttctcttaa tgacattctc ctaaacactc 2310001 cttatggata ttttttgatt cgtatactgc tgcgttgatt gctgcattct gcggagtaaa 2310061 tctatctgaa tatttaaaca ggatcacata attgctccaa ttgtataaca aaaagcgaat 2310121 cgttaccact gttttaaaac gacgtttttt tgacccaaca gctcttttaa gcgatataac 2310181 acctggtgat ctgcattgat atggaacgac tcaggtagct taatcgtctg tttttgcctt 2310241 tcataataga gataaacgcc tgtttcccct ttatgctcca gcaaaatgcg cttaatcttt 2310301 gccaggatct cctggctgtg ctgactgctt tctattttta tataaaccga tggcgctttt 2310361 tctgcatcca tatcttctaa taattctgcc cgggacatga tgaattggat cttatcttgt 2310421 ctaacttcac atttccccgc agtgaacaaa agagcgcctt ctcttaaaac gggagaaagc 2310481 tgtctgaatt gttcagggaa gactacggct tccatctcgc cggtttcatc actgagcgtt 2310541 aaaaacgcca tgttttgacc tgttttcgtc cgaatcgttt tgatcttcga cagcagaacg 2310601 cctagtgaaa gctgcctttt gactgcccgc tgagcctgca gaatggagac tgctccttgc 2310661 gcagtgagct gttttcggaa ggcggagagg ggatgatttg aaaaataaat gccaagcgtt 2310721 tccttttcaa acgcaagtaa atccaccaga ggaagctcct ccgtctccac atacttcggc 2310781 ttaattgaaa acgattcatc taaaaacaat cccatttggt catcgtccgc ggcgaatagc 2310841 tcagcatgtt ccaaagcaac atcaatggat gcgagcagcg tggcccggtt ttggccgaat 2310901 tcgtccatcg caccagaaaa gataagtgct tcaagcattt tgcgatttac gctttttgac 2310961 ggcacgcgaa agcagaaatc gaaaagatct tcaaatggtt tctcttttct tgctttatat 2311021 atatctttga ctgctgagac gcctacactt tttatcgcgc ggaggctgta tctgacagat 2311081 ccgttttcaa ctgtaaacgg aaaactgctt ttattcactg acggaggaag gatacgaatc 2311141 ccgctcccct ttgcttcgta aagatattga gagattttat cctcattgcc aatgacgctt 2311201 gtcagcaatc cgcacataaa atataacgga taatgagctt tcaaatacgc aagctggcac 2311261 ccgatcatgc tgtatgccac cgcatggctt ctgttaaagc catagtttgc gaatttgacg 2311321 attaaatcgt agacctcatt tgcagtgtct acagaatact ccttttttaa gcacccttca 2311381 acaaaatggc ttcgctctct gtccaggatt tcttttttct ttttgctgac cgcccttctc 2311441 aataggtccg cttcgcctaa agaaaacccc gccatacggg aagcaatcat cataatttgt 2311501 tcctgataca caatgacgcc atatgtatct tccaaaatgc tccttaaatc ttcatgagga 2311561 tagtgaacag gcgcccgacc gtgtttacgg tcgataaata acggaatatt ttccatcgga 2311621 cccggccggt acagtgcatt gaccgccaca atatcttcta ggcccgaagg tttcagccgt 2311681 ttcaagacgc ttctcatccc tgcagattca agctggaaaa tgcctgtcgt atcccctttt 2311741 gacagcaagg agaacgtttt gtcatcgctg taggaaatac ttgaaaggtc tattttaata 2311801 ttttcttctt tttcaatcat tgaagtgatg gattcaataa gtgtcagatt cctcaaacct 2311861 aagaaatcca tttttaaaag gcccaagtct tcaagatggt ccatcgcgta ttgcgttaaa 2311921 tagatccctt catgcccttc ttgaagcgga acaacatctg ttaacggttc ttcactcagg 2311981 acaacgcccg ctgcgtgggt tgatgcatgc cttggcagcc cttctatttt ccgggcaatt 2312041 gaatagactt gctgaagcag gcttgactcc cgaagccgct tatccagctg cggtgactgc 2312101 tgtctcgctt catccagcgt cattcccggt cttgaaggaa tgagttttgc aagctgatct 2312161 gcctccttcg ggctgacgcc gaatactctg ccgacgtccc ggagcgccgc ctttgccgca 2312221 agtgttccaa aggtgataat ctgtgcgacg tgcattgcac cgtatttctg ctgaacatat 2312281 tgaatgactt catcccttct agtatcggga aagtcaatat caatatccgg catgctgacg 2312341 cgttcgggat ttaaaaatct ttcaaacaga aggtgatgct taatcgggtc aacatctgtg 2312401 atatacagca catatgccac aagagaaccc gccgcagaac cccttcccgg tcctgtaaca 2312461 atcccttttt catgggcgtg cttcataaaa tcccacacga tcagaaagta atcgctgaac 2312521 ttcatccgct tgatgacatc aagctcatat tgaagacggc gaaggtatcg ttcatcaggc 2312581 ttgccgaaac ggctgcggag tccctccata cagatatccg ttaaataatc atcagcggac 2312641 gttccgtctg gggtcggaaa agacggtaga cgggtctgcc cgagactgac gtcaacccgg 2312701 cattgttccg cgatctctac agaagcttgc agtgcctcgg gatgctctcg ataaatgttt 2312761 tgcatttctt cgagtggttt caaatcgaga tcaggcaaat cttcagcggg tgcatccgtc 2312821 agtttttccc ccgctttaat cgctttcaaa caacggtagg cagccttatc ttccttcctt 2312881 atgtaatgca catcgcctgt ggccgtaaca gggatacccg tttcttctga cagctttaga 2312941 atctgctcag acaagacttg attcccttta aaaggctgat aggagaaata aaaagctccc 2313001 tttccgaata tagactgaaa ttccagcgag gcttgagcag cctgttcgaa cagccctcct 2313061 tcaagaagcg tttcaatata tcctttttcg ccgggcgtta ttgcgataat cccttctcga 2313121 taactgtgaa gccatttcgg cttcagtccg ccttttgatt tagattgcag aacgctgctg 2313181 attttcagca ggttttgata gcctgtattc gattttgcca gcaggacgag cgggtatgct 2313241 tcaagctcgc tgtcatctgt aaaaacagaa gccgtcaaac cgattattgg gttgatccct 2313301 ctcgccttgc aagctttata aaattgaata gctccgtaca tgacatgatc atctgtcagc 2313361 gccaaagacg catatccgag cctgtcagct tcactgacga gttcttccac agccgcggcg 2313421 ctgtttagca ggctataccc gctatgcact tgcaggtgaa caaaagacat gctatcacct 2313481 ctttctcatt acgatccatt tcttccttca ttataaggcc ggtttccaaa agaaacaaat 2313541 gttctttttt gactcatcat catacttgtc ctgaaagctc aatatgatat aaaaggtgag 2313601 gtgataaaga tggatcagga agcaggattt atggtgaatt ttatcaatag ctacttcatt 2313661 gcgttagggg tgctgatcgg gggcgcactc atcggagggc tcggagcata cttggcaggc 2313721 gaacccccgc ttacagccat tacaaagctt gccaaccggt taaaaatatg ggcgcttgtc 2313781 gcagctatcg gaggcacctt tgatgcggta tacagctttg aacgcggcat actcgaaggc 2313841 aatacgagag atatctttaa acagcttctt ttaattattt cggccatggg gggcgcgcaa 2313901 agcggctggc ttattatatc atggctgacc caggagcatc tttcttcatg agggtccccc 2313961 agcattacaa aaaaccggga tggcagcgtt ttttcgcggg aatgatgtgc ggagccgtaa 2314021 tcagctggtt ctttttcctg tttacttacg gaacattcca agaggagcag gtcagcctca 2314081 tcgaaaagca aaaagagcat gtaaaagact tgaacaatca aatttcgatc tatcaggaag 2314141 acctccataa actgaatgaa gataataaaa gaaaactgct gattcaaagc gtcagcgtca 2314201 aattgctgaa tggggataaa tataaaatat cacagccgga taaaacgaaa ttcgaggagc 2314261 atgtaaagga tgatatttca gaggtgatta caaaagacat agagagcgtc tatcaaacaa 2314321 aggatctctt gaagcggaca attgaaaata aagtctatat gatcaatgaa aaaaaatacg 2314381 aggcaaccgt cagagaattg attatttata cgaggctgac agtggaactt gaaatttctt 2314441 tcgccacata attatggatt ttttttaaat tctccaaact tctgtcgctt tttcccattc 2314501 ttttttataa actatatgtg aggcttaatg gcgaaaggaa ggaggaaggg aaatggaggt 2314561 ttacagtgac cgtcagttag caaaagatca agcagcccgt ctcagacaag gtttttctgc 2314621 atatgccgaa acaaactcac tcgcttccct catcaaaaaa gaacttcaat cacacaatct 2314681 ccaagtctac gaggacctta ctgatttcgg ctgctggttc atccccgtca cagatgaaca 2314741 ctaagagaga gggtctcccc tctactcgtg ttctttacat aatgtttcca gatcagctaa 2314801 aatacgatca gcttcatccc agctgtaaat agaggcgcct gaagctaacg gatgccctcc 2314861 gccgttatat ttccgggcaa gtccgttaat gacaggcccc ttcgaacgga atctgactct 2314921 gatttgatcg tcttcttcta cgaaaaacac ccaggcgcga atacctgaga tattgccaag 2314981 cgtcccgaca agctgcgacg cttcagaagc cgttgtgccg aatttttcaa gcgtatcctt 2315041 tttgatgaaa acagaagccg ccccgttttc ggacaaagac acattttgaa agataaagcc 2315101 gttaagcttc accacattca gttttgtttc atacaattga ttaaataact ctgaggaaga 2315161 gaatggatac tgaatgagct cgcctgcata ttttagtgtt ttttccgtgg tattcggaaa 2315221 taaaaagcgt ccggtatctc caacaatgcc ggcgtagatc agctctgccg ctttcgtatt 2315281 cagcttccag ccgtgctctt ttccttctaa atacagctcg taaatcattt cacttactga 2315341 gctggcgctt gtatcgaccc agagaaggtc accgtatgga tcttcgttcg gatggtggtc 2315401 gattttcatt agtttggcgc ctgaaggata acgctgatcg tcgattcttt cctgatttgc 2315461 cgtatcgcag acaatgacaa gtgcgccttc atatgtttca ttgtccacct catcaaggga 2315521 atataagaaa gagagggacg gttcaggcgt gccgaccgca aaaatatttt tttcaggata 2315581 tgtttcacgc aggatttccg taagcccaca ctgtgatccg taggcatccg gatcaggacg 2315641 cacatgtcta tgtaagataa tcgtgtcata taatgatatg gttctgatca attctgtttt 2315701 catttgatac tcctttattg tttttattca ttaaatcaca ttctctgccg acggaaaaga 2315761 aaaataacgt caaaaccaag cccgtttttg tataaaatgg ggttgtaaac ttttacgatg 2315821 gaggatttca tttatgctgg ttcttgtttt tttgattggg ctttcagcct gcttttatgt 2315881 gtactataaa gtaaaaggcg tacgggcaaa gccatctttg gcaaaagaaa tatgttcagc 2315941 aaaatcaagc atggccttag ggtcactagt cctgttctac gggcttaacc aaatgatatt 2316001 attccattca gtattaacgt tagtaatcgg cggtatcttt atcgtcatag gagcaggaag 2316061 cgcttgggca ggttataaag ccttcaggca ttacaatccc cttcacgcca aagaagctga 2316121 aagagatcac gcgtaagggg cgcctgaacg tcccttagct tctttccatc agctgaacca 2316181 tcagcatcgc tttagacacg atatgacctt ggctgtgcac ttccacttcc attttcccaa 2316241 actttctgcc ggcctccaag atgcgaggtt tgacttcgat gactgattcc atctgcacag 2316301 gcttcaaaaa gaagatggtg atgctctcta tgacgagttc gccgcgtttt ttcgagcgca 2316361 aaaatcggtt tgccgcttgc gtcaaaatgg tcgtaaatac gccataagaa atggttccaa 2316421 gctgatttgt catttgcggc gtgacttcat actcgtaaac cgtttgatct tctttatcat 2316481 caccctcatc tttaaacccc cttgaaacga tatcatcaag cttctccccg acctgcggct 2316541 gcttttgaat catttgaaga gctttcaata cgtcttggcg gctgatcatg ccgatgagtt 2316601 tttggtggcc gtcagtgacg ggaagcactt cgatcccttc ccataccatc atttgcgcag 2316661 ctgaagcgac agatgttttc ccaataaccg tgacgggatt tttggtcatg actttttcta 2316721 tagatgcatt tcggtcatgg ccagcaatat cttttgatgt cagaatgcca tggattttca 2316781 tttgatcgtc gacaaccggg aagcggccgt gccccgtttc aaaatttttc tcataccatt 2316841 tttcaagttt atccttaggc gaaagatata ccgtgcggtc agcaggtgtt aggatgtcct 2316901 ccaccaaaac aatttctttt ttgatcagct ggtcatatat tgcccggtta atcatcgcgg 2316961 caactgtaaa ggtgtcatag ctcgtggata aaatcggcag ttcaagctca tctgccagct 2317021 gcacaatgct gtcatccgtg ttaaagcccc cggtcaccaa tacggccgcg cccgcttcaa 2317081 gcgcctgcct gtgtgcattg attctgtttc cgacaatcaa aagattcccc gctgcggtgt 2317141 aacgcatcat cgcgtcaagc tccatcgcgc cgatgacgaa tttattcaat gtcttatgga 2317201 gccctgccct gcctccgagc acttgtccgt ctataacatt tacaacctct gcataggtaa 2317261 gcttttcaat gttctctttt ttcttttgtt caattctgat tgtgcccaca cgttcaatcg 2317321 tgctgacaaa ccctttattc tctgcttcct tgatcgctct gtacgcggtt ccttcgctta 2317381 ctttcatttc ctttgcaatt cttcggacag aaattttttc accgacaggc agtgaatcga 2317441 tatacgttaa aatttgttca tgcttcgttg ccaagccttt cacctctaag gacagtcttc 2317501 ttgtttttat tataaggttt caaaggattt atacgcaatg aggctggaaa ataaaaaaga 2317561 agcccgaccg gcttcttaca gcgttgattt cgttccagtc aaacgcaagg accacgtgat 2317621 tccttttaca tcgtaaagcg gaaaaacctt tatttttctt ttaaatggac atcaaccgct 2317681 gtcttaacaa tatttcgatt ccctatttta gataaaacaa ataaaactgc ggatagccat 2317741 atcgccccta tggccgtata gatcaatgga tgaacagctg tgtttgcgat ccattcattt 2317801 attaatgttc tggcatttac cagaataata aatcctccta caagcacacc catcaattgc 2317861 ggatgaaact tctgcaccag ccatgctgcg ataggggcag cgataattcc gccggccatt 2317921 agtgaaaaca cccataacca attgacgtcc tcccatccta atgaaataag aaaaccggcg 2317981 gttgcagata cggcgatggc aaattcactt gtgtctacag tcccgacaac tttcctcggg 2318041 ctcaagcctt tgcgggataa taaaatcgga gtggtcaccg gtccccagcc gcctccgcct 2318101 gtggcatctg caaaaccagc gatcactccc aatgggatgg attgttttcg gtttaacggc 2318161 acatgcttct tctcaagagc cggcttatat tgaaataaaa acctgatcaa tacatatccg 2318221 cccagaagga gcaaaaacaa agaaatatag ggtttcgcca catctccagg taattggctg 2318281 aggaatgccg cgcctaaaaa agcgcctata gagccgggaa tgacaagctg ataaacggtt 2318341 tgtttgtcaa cattgccaaa tttaatatgc gacactcccg atgcggcagt cgttacgact 2318401 tccgctaaat ggacagaagc cgaagccaca gcaggtgtga tgccaaacgc caataacaaa 2318461 gaagttgagg taaccccata agccatacct aacgaaccgt ctattaactg cgacaataaa 2318521 ccaataaatg caaaaacgat taatttcttc atcagaacac cccatctata tcaatcagat 2318581 atttttgact cttcattcga atctaacaat ctcttggcgc tttcatataa aaaataagag 2318641 gctttgataa ttgcagtttc atctattgta aatgcagggt ggtgccaatc atgatcaccg 2318701 tctgttccaa aaaacgcaaa ggatcccgga atatgctcaa gataataagc aaaatcttcc 2318761 cccgcggttg atggggcggg atcaatgact tgaagtttcg ctttatgtgc agcgtctcgc 2318821 accagccccg taattgcctc atcattacaa agcggcggcg gtccggaatg ccacttcaca 2318881 tttgccttta acgagaaagc ggcagaaatc tgctctgtga ctgcaaaaaa acgctgtttc 2318941 acttgattac gaacctctga atcaaatgta cgaacagtgc cctcaatgac cactgtatcc 2319001 ggaatgacat tccaagtgct gccgccgttg attttcccta cggttaaaat cgcgctttgc 2319061 agcgggttta catttctgct tacaatcgtt tgcagggcga caataagctg agaggcgccg 2319121 ataattggat caaaaccatt atgcggcaat gctgcatgag cacctttccc ttctatctct 2319181 actttaaatc ggtcaacagc agccataagc gggcctgttt ttaaccctac agtcccaacc 2319241 gcgatatccg gtttattgtg aaggccaata accgcatcaa tgccatccag ttggccgtcc 2319301 tctatcactt ttgtagcgcc tgcacccgct tcctctgctg gctgaaataa taaacgaatc 2319361 tttcctttca gactgtcttg attttccttc aataaaaagg ccgcaccaag aagcgctgcc 2319421 gtatgaaaat catgaccgca cgcatgcatg atccctttat gtttagacgc ataaggcaat 2319481 cctgtttttt cttcaattgg caaggcgtca atatcagccc tcaaagcaat cgccggacct 2319541 tctgactccc ctgctatgtc tgcgaacaca cccgttttta gagcagtagg gcgaatctgt 2319601 atcccctttt ctttaaggca tttttttata aaagcagttg tttcaaattc ttcttttgac 2319661 agttcaggat attggtgcag gtgccggcga atgccgatga gctgcttttc tagcgttgag 2319721 agatttacgg gattagactc ctctttcaac gtcaggatgt catttcctgt agtctgatat 2319781 ggataggagc cttctatatt tctccaataa tccaaagaca tatgttccgc tcctttccct 2319841 atcccaatat attttcttca gactcttcaa cataagatga aataaatcgg ttcaatttat 2319901 cagcaagacc gcccgcccca aatcttatat acttgctgga aactttcgga ttatcttctt 2319961 tcaaaaagct taaaaaagat aaaatataaa tgcgcctgta agctacttgt gtaattccgt 2320021 actcaaaaaa ccagttatca atgacattgt atacgcctcg gttgacgcca tataggttat 2320081 tacatttctt gtaaaagcag agatccggaa gatttaactc ctgatgggaa agaaggcttt 2320141 cttttttgtt tggtgccata atcccaatca gctcaaagcg ttttgcaacg cacgaaatat 2320201 cctttttaat ttgctttgtt aaagactcca aagaatcaaa ccttctttct tctctaattt 2320261 taaagagaat gctgcattcg attttttctc cataaatgtc tctatgaaag tcaaacaaaa 2320321 aaatctccaa tgtcttttca aggttagagc ccaccgtcgg tttcacaccg atattcataa 2320381 cccctaaatg aaattgatga ttgactgtcg ccagaacccc ataaactcca ttacgcagcc 2320441 catgtatttt tgcatctaca tttgccgtgg ggaatccaag ctttctgcct aattgttttc 2320501 ctttcacaac cgtaccggca atgatcgtca aaaaagtcag cctcctctct cagcttccgc 2320561 attcgatcag acgaaaccta atgatgtgat gaatgtaaaa cggattgatg ctgcggaatg 2320621 ccaagaccga gattttcccg caatgtcccg ccgcgataat cttgacgata aagccctctt 2320681 tcttgaagaa tcggaatcac cttttctaca aaagcatcaa gtgttcccgg tatatccgac 2320741 ccaacgataa acccatccgc cgcctcagcg ttgaaccaag tttcaattaa ggatgcgaca 2320801 cgctctggtg ttccgatgaa tagagtccgt ggaaaagcca tttcctgtgc tacctcccgc 2320861 aatgtcagat ttctggcttt tgcttctctc ttaatccggt ctgttgtgct ttgaaacgca 2320921 ttctttccca catcgccaat atcgggaaat ggctcatcca acgggtaaac actcagatca 2320981 taatcatcaa aaaaacgggc caaataagta acagcatttt caatcggtat caattctgca 2321041 aattcacgat acttcttttc cgcctcttct tccgtatctg ccacaatcgg gctgatccct 2321101 ggaaaaatcc gcacacttga aggatcacgc ccttcatcag cagctcggct tttcacatcc 2321161 gcataaaacg cttttgtctc ttctaatgaa ttggaatggg taaaaatcgc atccgcattt 2321221 ttagcagcaa actgccggcc tgtttctgat gaacccgctt gaaacactac aggctctccc 2321281 tgcttagagc gcccgatatt caagggcccc tctacttgaa aatactttcc tttatgattc 2321341 aggcgatgaa gcttcgcctg atcgaaaaac tgccctgttt tcttattgtg tataaatgcg 2321401 tcatgctccc aggaattcca cagcccgcgc acaacatcca aatgctcttg tgcgatctcg 2321461 taacgttcag tgtgttctgg caaattagac ttactatggt tgcgcgccgc tccttcctgc 2321521 ggcgaagtaa ccagattcca gccggccctg cccccgctga tatggtccag cgacatcaat 2321581 tgtctggaga tagtgaatgg ctcagtaaaa gatgtagaga acgtccctac taaaccaata 2321641 tttttggtaa ccgatgccag cgcagataaa atggtgatcg gttcaaaacg gtttaaaaaa 2321701 tgaggaatcg atttttcaga aataaataag ccgtctgcaa tgaaaataaa actaaacaaa 2321761 cctttttcag ctgtttgcgc ctttttcatg taaaattcaa tattcgtgct ggccgaggga 2321821 tcaacatcgg gatgacgcca gccgtcagtt gttcccccga caccgtgaat catggctcca 2321881 aactgaataa aatctgcacg tgtcatcttt ttgcctcctt tatctgtgca tgattagcaa 2321941 gtgcaagatc aaggtgttca atgccgattt cagttatccc ttgatactga ttgccgcgcc 2322001 cgatttcgac cacaggcaca tggcgcaccc catatttcac ctgtaaaata tcccgaagct 2322061 tttctttctc tgaaacatcg atattttgga acgggaaccc tttttcattc aaataattct 2322121 tgacttcctc acaatacgaa cagccttttt tactccaaac cacaatgttc acaacatcac 2322181 tcattcttct gtccctcctt aacgttttgc agctaaaact gcatcgctca gcagctgata 2322241 agacagctgt ttttctacag catttttgat cggtgtaaaa ataacaaaat cattgatttt 2322301 gtatgtgcct gataaacgtg ttaattcttc tgccacttct tcctttgttc cggcaataat 2322361 cccggttttt tgcacgatga tgtcataggg ctctgtgacg ttttccagat aggcctcagc 2322421 ctgttcgcgg gaaccgacgt tgaccttacg cccgtctttc aaaaccactt ttatcgattc 2322481 acgcgacaca atatgttttt ccgcttcttc ttttgtatgt gccgcaaaaa cagcgggggc 2322541 aagatgaaat tcagcctcag atcctggcgg gagatgcgcg tcaaatgctc ggcgggcttc 2322601 cttcagcact tcctcttcac cgttaataaa gtaagcaaag acaaaagaga ttcccagttt 2322661 tgcagcagaa atggcactct ctgtgcttcc tcccaataga aaaatacccg gcttccgatc 2322721 aacctgcggc ctaggacgca atgcggcata gcggtgggta tcaggaaaat catcccgaac 2322781 gaaatgagta agctcctcca gtttttcatc aaactgacgc accggttttt tatattcggc 2322841 ctgcagcgcg tctgtggaca gctgaaaccc gccgggcgct ttgcccactc caagatctat 2322901 acggccggga gctaacgctg atagaagatg gaattgctcc gctactttat aagagctgta 2322961 atgctgcagc atcactccgc ctgatgctaa acgaattttt cttgtgcttg cagcaagata 2323021 gcctaaaaga acctcgggtg cagaccctgc aatctcatca ttgttgtgat gttcggccac 2323081 ccaaaatcgg tgatatccac attcttcagc catttgtgcc aatttcactg tatgctgtaa 2323141 tgtatcagct gctgtctccc cttcaccaat caagctttgg tctaaaatac ttaagcggat 2323201 catatcaccg gctcctttat gtgttctttt ggttcaaata aatattccgg cgaaacacgg 2323261 cggagaaact gcctcgttct gtcttttttg gtatggcgga agacttcctc cggggttcct 2323321 tgttcaacaa tgactccttc atccataaaa acaacttgat cagagaccct tcttgcaaac 2323381 tccatttcat gtgtaacaac aatcatggtg gctccggttt tcacgatttc cagcattacc 2323441 tcaagcactt caccgaccag ctccgggtca agcgctgccg tcggctcatc gaacagcagc 2323501 acatcaggat gaatggcaag cgcccttgct atccctaccc tctgcttttg tcctcccgat 2323561 aactgactcg gataagcgtt caatttatct tgaagcccga cctttctcag ttcattttcc 2323621 gctacggcat acgcgtcttg ttttctcatt ttccgggcaa tcgtcaagcc ctccatgaca 2323681 ttttcaatca ccgttttgtg agcaaacagg tggtattgct gaaataccat tgccgtctgt 2323741 tttctgagcc agtgaacctc ttttttggac ggaaagcggc aattaatcac tttgtcatgt 2323801 atagaaatga tcccttcgtc tggacgttct aataaattca ggcaccgtaa aaaggtggtt 2323861 ttccctgatc cgctcggccc gataatcgtc acaacttctc ccttgcgtac cgtgagattt 2323921 atccctttta atacatggtg gatgccaaac tgtttatgga tatttttaat ctcaatcata 2323981 aagtgcctcc ttgaaatctg gctgcctttc tctctaatac tccatttgcg gattctagga 2324041 ttagagtcag cacccaatag ataatcgctg ctccgataaa cgcttctaaa aatgcataat 2324101 tatcagaagc aacgatagtc gccgtccctg taatctctgg gacagccact atagccgcga 2324161 tagaggtggt atgcaaaaag ccgataccca aatttgtgaa gtttgggatg gaaaccttca 2324221 gcgcctgcgg caatattaca cgccgaaagg tttggctgta tgtcaagccg attgaataag 2324281 ccgcttcgac ctgtccggta tccatcgcca gaatgcccga ccggatgatt tctgtgagat 2324341 aagctccggc agttaaagac aaggccatga tgacaaacat ggagaccggt atctcattag 2324401 cggaccagcc gagatgaaaa aaactgctga cttgatctgc aacaggcggt atccctaaat 2324461 aaatcaacat aatgtgaaga attgcaggtg tacttcgaaa gaaagacaca taaaaccttg 2324521 agcaagccac caagccctta attctaaaaa ttctaacaat tatatttcca agagccacga 2324581 gaaatccaaa cacaatcggc aaaacagcca tcatcaatgt cagaggaatg gtctttacca 2324641 tttctttcat ggcggaaacg ataaatggaa agtcaaattg caatcttctc ccccctcatc 2324701 cgaagaaata tatcaatgta tgttcatgtc aaaaacagta acaatccttg tttgattctt 2324761 cttgattcgt ttttctgcca ctcgaaagaa ccattcgaat aaaaccgcta cagcataata 2324821 aacaatcgat agcgcaatgt aaacttcaag agaatggttg cttgaggtaa tcagtgtttg 2324881 gccccttccg gacatatcca taacacctat tgaaaaggct agagacgtat cttttaaaga 2324941 actgatcacc atgtttccca tattcggaaa cgcctggaca agtgcctggg gcagaacgat 2325001 tcgcctgaag gcctgactac cgcttaagcc aatactgtac gccgcttccg tttggccttt 2325061 atctacactg cccacccccg ctcgaatgat ttctgcggct gccgctgcat tgcttaacgc 2325121 gtaggttgcg acagcagcat aaaacgggtc catttttgat gtatcaatcc cgataagccc 2325181 cgtaagcgcc gggatcccgt aaaacacgat gaaaagctgc accatgatag gcgttcccct 2325241 gaaaaacgag atatacactt ttgccaattg atttacaatt ggaatattat agatgcgggg 2325301 cagtgccaga aagagtccta atacaaaacc gaaaagcaag gacagtgtta aaatgtataa 2325361 tgtaaccggt aaataagcgg ttaacgtcgg cacaaaatct ccaatcatgt tcatatcaaa 2325421 cgctttttcc atcactgctc cctctctttt tacctaatac tgctctttgg aatagtcgtc 2325481 accaagccat ttcaaactga gccttttcaa cgttccgtca tcaatgattt cctgtaaggc 2325541 tttatcaata tcgtcactta acgtttgttc atttttgtta aacataaaat acactttggc 2325601 atttgaaagc acattaccga cggttttttc tttaatagtg ctcgtcttgt tttgaaagtc 2325661 tactgcaaaa ggcgttgaga tcgttgcgtc cgcacgcccc gatttcagct gattcgcagt 2325721 ctcatttgcg ccttggccct cataggcaat ctcaaacggc cgtccattat cctcattcca 2325781 ttttttcagt acaagcgctc cgttggaggt tgcactcgta atcacccgtt ttccttttaa 2325841 gtcttcaatt ccacggatcg tatcgttatt ttgaagcaca gtaattttta aaggaaaatg 2325901 gttgtaagca accttgttaa acagaaattt tttctcacgc tctttgcttt tctccatttg 2325961 atgtgccacg atatcgactt tatgctgtcc gaggctgaca agcaggttgg aaaattccat 2326021 cgttttaaat gtgaatttat aatgtggcag gcgcttatca agctctttga tcagttcgac 2326081 atcataaccg gttaaatcgc ctttttcatc gataaagcaa atattcggaa attgggttcc 2326141 agttccgacc gtgatcgtct gtaccttctt ttgcccggct cccgtcgttt gactgcctgc 2326201 accgcaagct gacagaactg ttataagcga aaataatatt gccatgaatg ctgttttcgt 2326261 tttcatctca tcgccccatt tatttttcaa aacttgattt tgaataatct gccccgagcc 2326321 attttcggct tagttttttt agcgttccgt ttttctccag ctttttaatc gcttgatccg 2326381 tgtcatccgc caaggtttgg ctgcctttat taaacataaa gtacacctcg gtatctaata 2326441 acacgtcacc gactgtcttt tggcggaagg cgtgcgtttt attctgaaaa tcgacggcaa 2326501 acggtgtagc tatcgttgca tctgcgcgcc cggtttcaat ttgattggcg gtatcattgc 2326561 ttccctgtcc cgcatatttc aaatgaattg ggctgccgtg cgttttgttg tactttgtaa 2326621 tataatctgc cgcatttgac gtggcgccaa ctatgactgt ttttccgtgt aagtctttta 2326681 atgtatgaat cttgtgatta tcctctttca ccgtgatgta catcggcgag tagttatatg 2326741 ggactttatg atacaaaaaa cgcttttctc gttctttatt tttggccata ttgtgcgcaa 2326801 tcacatcaat ttttttattt ccgagactcg tcagcaaatt tgagaaatcc atcgttttaa 2326861 attcaaatgt atattgaggc aactccttat cgatggcttt catcacttca atgtcatacc 2326921 cggtcaattc acctttttca tttaaaaacg caatattcgg aaaatctgtt ccagtgccga 2326981 ctatgaccgt ttgagcctga cgatctgttt tgttatttgt ttgcgaacat cccccgccaa 2327041 gtaatgcaaa cactgacagc agcaaaacca atcctttacg cttattcata ggctgcctca 2327101 catcatgccc agctgggcgc acctaaaagc gttgggttaa atcgttccgg aatcagaacc 2327161 ttgtgcatca tcacacctat gtccccgtct ttttcctgct caaaatacac ttcataccct 2327221 ctccttctgt acatgtcagc aagccaagga tgcttgcgcg ccgatgtgcc gagtgtcagc 2327281 gcaggagcct tcagcatatc tcgaagcact ttttcttcaa catacgtaag cagcttactt 2327341 ccggcgcctt gccctttata ttccggcagt gtcgcaaacc accacacaaa tggatatttt 2327401 gaaggaggcg tctcactctc ccacgggaac ctgattgtaa tcgttgaaat cagcttccca 2327461 tcccgctcca gcacaatcgc tgaatgatgt tcaatatttt ctgataccat ttggatatca 2327521 gctctcgtgg atggccaatc aatatccagc tgccgaatgg gctgaaatgc gctgttaacc 2327581 agtttcaaca gctccgatgc atcttcaaca gttgccagtc gaaaaatatc atcactcatt 2327641 tttgtcactc ctcttcacaa aatatataat tcctatttgt ttactaagct tttattgttt 2327701 atactataaa gcatactctg atctttgact aatcaaaaaa agtaaacctt cacttcagta 2327761 attttaatga tgaaaaacag gagggagcac attggagtta cgctcaatca aaacgtttca 2327821 tacgattgta aaatttggaa gcttctataa agctgcagaa atactcaact actcgcagcc 2327881 gacgatatcg atgcgtatga agcaattgga gcaggattta ggcgtactgc tgtttgaaag 2327941 aggaaaaagc ctgcagttga caaaagcagg gaagcttttt tatgaacgaa caggagatct 2328001 tttgatgcaa tacgaggcgc ttaaacacaa cctctccgac ttaaaggaag aagaggcagg 2328061 cattatcaac ataggggttt cagagccaac cgccagtctg atattccccg agattttaaa 2328121 ggatttctta atggattacc caaagataac ggttaatatc aaggttgatg acgccaatac 2328181 ctgcagtcaa aagctcttag acgggacgat tgattttgca gtctgcggcg agccggagct 2328241 gattcttgaa aattactacc atccattttt ttatgacaca ttaaatgtga ttgtatctga 2328301 tcaacatccg ctcgctgaga agaaggctgt ccatttgtct gatttagcag aagagcgctt 2328361 catatttacg cccgccaatt gccccattcg cttacaaatt gaacagcatt tacatagaga 2328421 actcgggaat cgctacaaaa aaatggagct cacaagcagc atgtcacatg aatattacgt 2328481 acgtgaaaac atcggaattt caatctttac cagcaccgca cattctaaac cgttcaacgg 2328541 cactaaagtc attccaattc tgaacctgga tatcaccccg cccatagggc tgttgacaaa 2328601 tcaaaaagaa gttcattttg accgcgccac gaaggacttg atcgcccgga taaccaaacg 2328661 ttttcagcag cgcagcaaag aattggaagg aacctctgat aagaccatta caggataact 2328721 gaaaaaataa aaaccacctc ctgattcatc aggagatggt ttcacggttt aaagctcgat 2328781 cgtctcaccg accgacatga ctttgccgac tccgcccggc aggctgtcag cgaatgcttc 2328841 tgggtcttgt tcgatgaccg ggaatgtatt gtaatgcacc ggcacgacct gttttgcgcg 2328901 cagccattca gcagcaagct tggcgtcttc aggccccatt gtaaagttat cgccaatcgg 2328961 aaggaaagca aggtcgatat gattcaattc gccaatgagt ttcatatcag agaaaagtgc 2329021 cgtatcgccc gcgtggaaaa tcgttttatc ttctacagtc agcaaaatac cggcaggcat 2329081 gcctgtgtaa gtgatcgttt tgttttcttc atctgtgatg gctgatccat gaaaggcctg 2329141 tgtgagcttc acttttccaa aatcgaactg gcgggagccg ccaatatgca ttggatgaac 2329201 attcaagcct ttccagccta agtacacagc gagctcgttc ggggctataa ccagcgcgtt 2329261 attttgcttg gcgatttgtt cagtatcacc gacatggtca ttgtggccgt gcgttagtaa 2329321 gatgacatcc gcttttacat cctccggctt tatatccgtt aatgaattcc ctgttaaaaa 2329381 cggatcaaaa ataatatgat ggtccttcgt ttccactgtg attacagaat gtccgtgata 2329441 tgtcactttc atttctttca cctcgtcaca tgattttgtt ttttttattt tcccttttta 2329501 aaaagctgaa aaacttatgt tgtttgattc ttgttaatga cattgaggcc tccggtggct 2329561 tcaatgacag tccctgtcac aaggtctgag ttctcctcac acaagaaagc gataatcctg 2329621 gcaatatcct cgcctgtacc ggatcttcct atcggcgttt tttctttgcc gattcgcatt 2329681 ctggcttcct ctatcgatgc ttctttcatg tcgccgacaa tgtctcctgg gcaaaccatg 2329741 ttggcggtta tgccgaattc ggcttcttca atggcaattg tcttcgtcaa agaagccaag 2329801 cccactttcg cagcgccaaa tgccgatcgg tgaagccagc cgggcgcgtg agccgcacct 2329861 tggaatccgt acgtaataat gcgtccaaat tgctgttttc tcataatagg aataaccgct 2329921 ttgaataaat gaaagacggc gcttaaattt ccttccagca tgccatacca ttcatcatca 2329981 gtataatcgg ctaacttttt acgttcaaat atgtatggtc cagcgttgtt aatcaaaaag 2330041 tcgatccttc cgaagcggtt taaggcagcc tctgcaatac gcagcagatc ttcttttttg 2330101 gtgacatcac cttttacaaa ttgcagccgg tcaagacaat cgggacaggc ttccttcagg 2330161 cggctgactg cctcctcatc ctgtctgtaa ttgactgtta ctgaataccc ctttgcaagc 2330221 aacgtttcag tcactttgcg gcctaaaccc ttcgaaccgg cagtaattaa agcatgtcgc 2330281 acatgaatac ctcccaaagc aacgtcgccg ctttcaataa agtgtttctt cttctacttt 2330341 actataaaag gcttgcaata tcacttttta cactttggca tacaaaaaaa gctgcctgta 2330401 cagacagctt attctgcagg agatgaagac tcctgatcag gcatatcgac ataaccgctt 2330461 tgatatgctt ctgaaatgag ccttgttgtc tcctggcttt cttgttcatc ataaatatag 2330521 cgttccggtt cttttttcat cattctgcct cccatcatta tagaggtagg ttggctataa 2330581 tgacgggatt ttatgaagga aattttaaca aactcctgct gccacgcaag ctttcgcttt 2330641 ttcaagcgcc tgttccacct gtttgaatcc ggtgcccccg gcgctcattc ttttttcaac 2330701 tgcgtagtaa gggtctaaca cagtgtaaat atcttcttca aatagtgtgc tcgcctgctg 2330761 aaactcgcca aacggcatat cgcttaaata gatccctctt tcgatgcatg tgtacacaag 2330821 tttcccgacc acttcatgcg cttctctgaa cggcattcct tttttagcta aataatcggc 2330881 cagttccgtc gcgtttgaaa agtcttgttt tgttgcttgc ttcatgacgt ctttgtttac 2330941 agtcattgtt tggatcatgc ctgtgaagat ttgcaggctg ccctccaccg ttttcaccgt 2331001 gtcaaacatg ccctctttgt cttcctgcag atctttgttg taagcgagcg gaagtccttt 2331061 catgatcgta aacagcccca tcatatcgcc gtatacgcgt cctgttttgc cgcggatcag 2331121 ctccgccata tcagggtttt tcttttgcgg catcatgctg cttcctgttg cgtacgtatc 2331181 gtcaagctcg atgaatttaa actcctgcga gcaccataaa atgatttctt cagagaaacg 2331241 ggataggtgc atcatcagca tactgctgtt gcttaaaaac tccaaaatga agtctctgtc 2331301 gctgacgccg tccaagctgt tttcataaat ggcatcaaag ccgagcagtt ccgctgaata 2331361 atcacggtca attgggaagg ttgttcccgc gagcgccccg cagccgagcg gagatttgtt 2331421 aatccgcttc attgaatcct gaaaacgctc cttgtcgcgc tcaagcatcc agaaatacgc 2331481 aagcagatgg tgagcgaatg aaatcggctg ggcgcgctgc aaatgtgtgt agcccggcag 2331541 aatcgtttca acgttcgctt ccgccttttc aatcagcgca ctttggaatg cctcaatcag 2331601 ctcgatgatg tggccgacat gattcttcaa gtataaatgc atgtcagtcg ccacctggtc 2331661 attccggctt ctgccggtat gcagcttgcc gccaagagga ccgatttcgt caatgagcat 2331721 tttctcaatg ttcaaatgaa tatcctcata atcgactgag aattccaatg ctccctcctc 2331781 tgctttttgc aaaagggtat tcaggccctc tcggattttc aactcttctt ctgctgtcag 2331841 aataccgcat tttttcagca tggcagcatg tgcgagagac cctgtaatgt cttcagcaac 2331901 taaattttgg tcaaatgata tggacgcgcc gaactcgtcg acccattttt ccggtgtttt 2331961 ttgaaatcgg cctccccaaa gcttcttcat gctttaatct gctccttctt tttcacgatg 2332021 ctgttcactt ttgtcggaag tccccaaagc tcgataaatc cgattgctgc atggtgatca 2332081 aatgcatcgt cttttgtata tgttgcaagt ttttcatcat atagagagta ttccgattta 2332141 cgtccttcta caattgcatg gcctttaaac agcttcacgc ggacaatgcc tgtgacatgc 2332201 ttttgcgttt cttttaagaa agcgtgcagc gcgtctttta acggtgagaa ccataagccg 2332261 ttgtaaatga tttctgacat tttttgctcg atgatcggtt taaagtgggc tacctctttc 2332321 accagtgtca aatcttctaa ttctttatgc gctttgatca gtgtcatcgc accagggcat 2332381 tcgtatactt cccgggattt aatgccgacg aggcggtttt ccacgtggtc gatacgtccg 2332441 acaccgtgcg cgcccgccat ttcattcagc ttcaagatca gctcagaaag cgagtaggaa 2332501 acaccgtcaa tggagacagg cacgccctgt tcaaatgcaa tttcaatcac ttccggcgtg 2332561 tccggcgttt tttccagcgg agctgttaaa tcgtatgcac cttctggcgg cgccgcccat 2332621 ggatcttcta aaatgccgca ctcattggcg cgtccccaga ggttttggtc gatagaatac 2332681 gggctgtcaa gattgatcgg aatcggaatg ccgcggctag ccgcatattc aatttcttct 2332741 tcacgtgacc actgccattc gcgaaccggc gcgatgactt ctaggtcagg gtttaatgat 2332801 ttaatggaga cttcgaaacg aacctggtca tttcctttcc ctgtgcatcc gtgggcaatc 2332861 gcctgtgcat cttctttttc cgcaatttca accagttttt tcgcgatcag cggtcgagat 2332921 aatgccgaaa caagcgggta ttttccttca tacattgtgt gggcctgcaa agagataagc 2332981 gcgtaatcct gtgcaaattc ttcttttgca tcgatcacgt aggagtttgt cgcgccgact 2333041 tcaagcgctt tctgctgaac aaatgccaaa tctttgccct caccgacatc caggcagcag 2333101 gcgattacat tatatccttg ctcctgaagc cattttattg cgacggaagt atcaagacct 2333161 cctgagtatg ctaatacgac ttttttctgt tctgacatga taaaaatccc ctctcaaccg 2333221 tgtttctatt ttgtataaaa ataaattata tttaataaaa atacattttg tatgtataca 2333281 ctttaacaag tacgtttcgt tttttcaagc cttttataaa aaaaacttca cctaaatttc 2333341 aggtgaagtt tcatagtatt tattcattta cttgtctttt ctgatttctc tgaccacatg 2333401 cgcaagttcg ggaataatca gcttattcat tgccagcttt actgcgccgc ttgagcctgg 2333461 cgttgagaaa acagcggtat gctgaatgac gccggcagtt gctctcgaca tgattgcggc 2333521 agagccgata tcctctgtat aactcagcat cctgaatatt tctccaaagc cgggcagttc 2333581 tttcgaaaac agcggcgtta tggcttcaat tgtgacatcc cgatctgcta tgcctgtccc 2333641 tccgtttaag agtaccgcgt ctgtctgttc atccatgcag cccgcaagca ctgaccgttg 2333701 caaagcatcc ttttcgtctt ttacaatttc atatgcggca atatgatgac cggcttcttc 2333761 taaaaatgag atcatcagct tgccgctttt atcggtttca tctgtcctcg tgtcactgac 2333821 agtaatcact ttgcaccgaa cgatatcggg agcttcttgt ttatgctctt gaacgctcat 2333881 tggcccacct cttttatgtt ttctgtctgt cactatcatg catcaacaaa aaagcacatt 2333941 caagagaatg tgctttcatg cgatttattt tgctaaacga acaacgtcgc gcgcaatcat 2334001 gacttcttca tcagtcggga tgatcatgac ttttactgga gaatgcggat agctgatgaa 2334061 agcttcctcg ccgcgcacgt tattaagcgc agggtcccag tatacgccca tgaattctaa 2334121 accgcgaaga acgcgttctc tgacttccac actgttttca ccgataccgg cagtaaagat 2334181 gatcgcatct acaccgctca ttcttgcagc gtaagaaccg atgtatttgt ggattctgct 2334241 tgcgaatact tcaagagccg tttccgcgcg ctcatttcct tctttcgtag cttcaacgat 2334301 gtcacgaaga tcgcttgaga aaccggaaat gccgagcagt ccgctttttt tgtttaatgt 2334361 attcagtact tcgtcagccg tttggcctgt tttctccatg atgtatggga tcagggcagg 2334421 gtcgatgttt ccagagcgtg tgcccattgc tacaccggca agcggcgtaa agcccatgga 2334481 tgtgtcaata gattttccgc cttcaacagc ggcaatactt gctccgtttc caaggtggca 2334541 ggaaatcagg cgcaagtctt ttaacggacg gccgagaagc tctgccgcac gctcagttac 2334601 atatttatgt gaagtgccgt ggaagccgta tttacggatg ccgaattttt catagtattc 2334661 atacggcaag ctgtaaaggt aagactgctc aggcattgtt tggtggaatg ctgtatcaaa 2334721 tacagctacc gcaggaacat ttggaagcac ttctttgaac gctttaattc caacgatatt 2334781 tgccggattg tgaagcggtg ccaattcaga aatatcttcg atttccttaa tggtttcatc 2334841 cgttaataaa acagaatcgc tgaatttttc tccgccgtga acgacacgat ggccaattcc 2334901 gtcaatttca ttcaagtctt taataatgcc gaattccgtt aacttattca gcagcatttt 2334961 aacagctacc gcatgatctg gaatatcagt tacttctgta tttttttcgc cgttcacaga 2335021 aattgtgaat acgctgtcgg cgataccgat tcgttcaact aaacccttcg ttaaaacggt 2335081 ttctgaaggc atttcgaaaa gctgaaattt caaagacgag cttcctgcgt taattgcaat 2335141 aattttggac atgattgacg ctcctttata ctctgtatca acaacttcgt ttttcgtact 2335201 tttttcccgg tgaatatcaa catcttctcc gaaaaatatc tgacttttcc atttaaacat 2335261 tgtcatgtcg gcttttcaag tcaacttgcg tattgataac gcttacaata agaagtcgtt 2335321 attttcagac acattcacta taggttttgt attgatgaac gcttacaatt tgcggttttt 2335381 ccctctgtat tttgtgtttc aaagctggat tcaattcgtc aagtccggtc ttcaaaagca 2335441 taaataaaag cagcttaggc atcgacctca tacggctgtc taagctgctt ttaaaacact 2335501 tacttttctt ttttaaacca ttcatcaaat tgagccatca tatcaagcat cgccttttga 2335561 ttggagaaag acggaagatt cgcaagcaga atttgccccg gcgctttcgt attctctcct 2335621 tgtttctgaa gcacaaggat gcttttggca tgagcttcgt ctttaaaaat agattttggc 2335681 agctgcaaca gtgcgttgat atgaacctta tctttgaaaa actgtttcag cttgccgctt 2335741 tgggagctct caaacaaatg attcggaatc ataaaaaata agtagccgcc cggtttggta 2335801 tgcttgacgc tctgttcaat aaacagatga tgagcgaagg aatggccttc gtcagctttg 2335861 agctcaaacg cttctgctcc ttcgtcattc ggataatagc cgactggcag atcacaaatg 2335921 accgtgtcaa ctggatcgat aaacaacggc tcaaggctgt cctggtggaa aagctcaagc 2335981 tcttttttca gaaggttcgc ttgggcatag gcgatcttca agagcacatc atcaatttca 2336041 atgccaaagc tgtttgccgt tttttcagac agctggttca gcacggtaaa cagaaggttc 2336101 ccagttccca gggctggatc aagaatggtc agttcctttt tgtccgccat aaatttattc 2336161 accaaatagc tgatgaaaag cccgatcgta tccggcgtca tttgtctgtt tggatgcgag 2336221 atatctttca ttcctttaag gacggcaagc tgaaaagcct tgcgtaccca ctcatgctca 2336281 tacgtgccga attccgcttt ttcaagcaga gcctgaagtt gtttggtttt ctgatcagca 2336341 ggcagtttca gctgatccgt tttttcaaga aaatacattt ctcctgcttc ggccagcgcc 2336401 tctatatatg aaatctgcaa ttcattcttt atcataatcg cggcttcgtt taacagctca 2336461 tacaccgcac ctacatggtc tttttgcata ttgtgttcct ccttgccatg aaaaaagctc 2336521 cggcggcagc ctggagcttt tttccctgct tactttacta atgccttagc agcctcaatt 2336581 ggcttttcat agttcgggtg gtttgttgct tcgcttacat attcagcgta aacgactttt 2336641 ccgttctcat caaggacaaa tacggaacgc gcaagcagac gaagttcttt aatatacaca 2336701 ccgaacgctt cgccaaatga catatctctg tggtcagaca gtgtttccac tttgtcaatt 2336761 ccgttagcgc cgcaccagcg cgcttgcgcg aatggaaggt ctgcactgat tgtgtagacg 2336821 ttgacatctc caagctttgc agcttcttcg ttaaaacggc gtgtttgtgc atcacaaaca 2336881 cctgtatcaa ttgaagggat aacagaaata atcgttacct ttcctttcat gtcagctaac 2336941 gatttttctt caaggctgtt agtcagcact gtgaaatcag gagcttgatc tcctaccttc 2337001 acttcttgtc cgacaagtgt aaccggaccg cctttgaatg taatttcagc cattataatt 2337061 cctccctttt gtatgtatgt ctctatcata gtaaagtttc ctgcaaactg caaagtttat 2337121 gccaaaaaaa agttaactgc ggccagcgca gttaaccttt ttttaataat tcatattgtt 2337181 catttggttt tgattttggc cttggctttg gtttttgtta tttttcttga acatttgctg 2337241 gatgcgctcg agtgtttgag gggctgcgtc taaaattttc tctattaaat gggtattttc 2337301 atctaaatga agcattctga tgcctgtcga tccgacaatt aaaaacgcga tcggcgtaat 2337361 ggacacaccg cccccgcttc cgcctccgaa aggaagtttc tgttctcttg tctcatcgtc 2337421 ttccgatttc ttttcggccg gctttccgcc aaactcgctt ccgcctgcgg cgaatccgaa 2337481 tccaacttta gaaacagtta aaatcacact tccatcaggc gtttccactg gatctccgat 2337541 gatggtgtta acatcaatca tttccttcaa gttttccatt gcggttttca ttaaaccttg 2337601 gatgggatgg tctgccatat acgcttcctc cttaaactga tgaatcattc tttgaagtca 2337661 ttctagccga cggattcttc tttaatacgg atagctcccg tccgtatttg acgaatttga 2337721 aagctgcaag catagcatgt ccaaagcgaa aaaagaatat acactgaaaa tgggtcttgg 2337781 aaacagggac ttgaaacgac gggatcacct catagacagg tttattcaca aagtccaggt 2337841 ggtcgtagag cattgctgcg ataccgccct tcacgcccca tacagcaccg gttaacacac 2337901 ctgtcactgc cgcgtcctga attccgatta ctgtaaccca ttctagtttt gtgatatgta 2337961 aatgcgcgag aaaagacgcg ctgattttcc gcagtctggt gacctgatgc aaaagcattt 2338021 cgattttatt aatgctttgc tgcacatcgt tttgtgtaat ttttttcttt ccgctgcttt 2338081 ttttcatttt ggattcagtt ttttgtttga tatccactgt tccgtcttct ttgttcacct 2338141 taatcgccgg gattgttttt ttgatcctta taaggccaaa cagcgccgta atcttcaagg 2338201 tcaatttgtc attatcatcg gcatgaagat actccagcgc gacatggatt ttcattctga 2338261 gaagcagtac gatccctatg agaataagaa tggctgtcag tacatacacc atattcttca 2338321 cttcctctag gagcattatc gccaattcct aaaaaaataa acccggacgg aagtccgggt 2338381 tatcggttat ttgcggtata atttttcatg caccacggtg gtatccgcga tgtaatcatg 2338441 aatcccttgt tttgtaggtg aaaaggcaac aacgatatat aaaatccaaa tcttatcaat 2338501 ataccgtcca accacttcac gaaaaatcac tgtactccat gtcagcttgc tatcttgctt 2338561 cacagaaacc actttgaggc cgaacaccat tttaccaagc gtctgcctga agtattttgt 2338621 catgagtgcg aaataggcaa gatacacaat aagcgttgtc acactgtagg ccgagaaggt 2338681 aaacatgccg gatgttttcg gcagatccaa tacggtaaag aggggagaaa cgagcaaatg 2338741 gtttaatccc catatcacga gccaatcaag caggaaagcc cagaaacgaa cccaaaagcc 2338801 agcataggca tgtgtcagca gctccgcttc ttgcgggcct ttgatgtcat tgcgctctaa 2338861 ctcttcatat gtcgcgtcca ttattgttcc ctcctacttc gcatagagat acatcattct 2338921 cggcgaaccg gattgcgata gaatttctct catattcaaa aaatcaattt cacttttaaa 2338981 cattttgttc gcgcccatgg aaaacagtga gcctaatccg aagctttcct cataagaaat 2339041 gacagaggcg tttttcaaat ccttgtgatc ctttttcatg gccgtaatgg tatcgtcata 2339101 aaaaccaagc tcatcaacga ggttcagttt tttcgcctgc cgtccgtcat acacgcggcc 2339161 gtccgcaatt ttctttacct ctgctttcgg catgccgcgc ccttttgaaa tgacatcaac 2339221 aaagccttca tacgaattat caaccatcga ttgcatgatg tttttttctt ctttcgtcat 2339281 ctcacgggaa ggagacataa tgtccttatg ggccccgctc ttaatcgttt caaaagaaat 2339341 gccaagcttg tcggcaagct ttgaataatt gacgctttcc ataatgacgc cgagtgaccc 2339401 ggtcagggtt tccggtgtcg caaaaatctt atcagccgct gttgagatgt aatagcctcc 2339461 tgatgctgcc atcgaaccca ttgacacgta aatcggtttt ttcgtttctt tcttgatttc 2339521 ttccagtttc ttatgtattt cagcactttc atacactccg ccacccggag aattcacctt 2339581 cagaacgata cctttgaccg tcttgtcatc ttttgcgcgc tcaaggtttt ttaagaacgt 2339641 tctgtggtta tatccgtctg caccaagcag actgcttgag tccccattat cctgaatggt 2339701 gccgctgacc tctaatacgg caattttact tgagggactg ccgttttcca gcgtcttctc 2339761 ctgcgattca tccgtcagtg atgtgagatc cgtttgagcg cctttgacgc tttcaaagaa 2339821 actcatagag atgctgacga taatagacac gccgaaaatc cccagagcaa tcactaatgc 2339881 aatccatctt tttgcattca ttttttctcc tcctttttcc taaactctct cattatacga 2339941 ttcaatatga aaaatgtttc acttcatgag aaagctccgg cttaacgggc tgccggcaaa 2340001 cgtggtacac ttatggccaa aggtatttta tcacaaatac tggatggcag aaaaacttaa 2340061 atatgacagc aaaggggaaa tgggatatga ccgatcaacg ccgtaatgtt tatttttttc 2340121 acaaacagga tcaggaaacg aacgaacaag cccgctcgtt aacacaatta gcggaagagc 2340181 atggatttac cgttgtgaac cagcactcag acgccaatat tatcgctagc attggcgggg 2340241 acggcacatt tttgcaggca gtcagaaaga cgaattttcg tgacgactgc ttgtacgtcg 2340301 gcattaccaa aaaggggaaa gctcatttat attgcgactt tcatagtgat gagcgagaaa 2340361 aaatggtcga tgcaatgacg tttgaacaaa ttgaagtgag aaaatacccg ctgattgaag 2340421 tgacagtgga tcaagccagt ccttttcact gcttaaacga ggtatccatc cgctcaagca 2340481 tcatcaaaac ctttgtgatg gacgtgctga ttgacgatct gcactttgaa acgtttagag 2340541 gtgacggaat gattatctca acgcctacag ggagcaccgc ctataacaag tctgttgcag 2340601 gagctgttgt tgatccattg cttccatgca tgcaggtatc agagcttgca tcccttaaca 2340661 ataataccta ccggacactc ggctcgccat ttgtcctcag ctctgaccga aagctgaccc 2340721 ttcgtgtggt gcaggacggc aacgaacacc caatcatcgg cttggacaat gaagcactca 2340781 gcacgagaaa tgtgaaaacg atcgaaatca aactgtctaa taagaaaatc aaaacagtca 2340841 aactaaagga caattcattt tgggaaaaag tgaagcgtac ttttttatag aaaataaaag 2340901 gacaggctgc tgcctgtcct tttatgattt ctcatataca atctggccgt taatcacggt 2340961 ttttttaatc tctaaaagat gaagctgtgc ggggtcaatg gcaaacggat caccactgag 2341021 aactgtaaaa tccgcgtcat agccttccgc aatttttccg cgtgacttct ctttataaat 2341081 gataccggcg ctaccttctg tataaagctt tatcgcttca tatacaggta aacattcact 2341141 ttcattatag cttggcccgt tttgctcatg actgcttttc cggaggaccg cggactggat 2341201 ccctagaagc gggtcaacag gctcaatcgg ggcgtctgaa ccgcccgcgc ataaaatgcc 2341261 tttagatatg agggttttcc aggcaaatgc agtcttcatc cggtcttttc cgagacggtc 2341321 aatgacccac ggaaagtcgc ttgcaacgaa gtgcggctga aggtcaagtg cgatcggcat 2341381 gcgtgctgct ctctcgatta attcgttatc aagcacttga gcatgaataa gccgatcatg 2341441 ccggccgttt ttgggcggat gcttttctat tgcgttcagc actttttcaa aagcaagatc 2341501 gccgattgca tgaacagcaa cctccatccc tttttctctc gctttgcgaa tgagccggcc 2341561 aagggtttcg tcatcgtgaa cctgaacacc atttgttgat ggatcatcct gatatggttc 2341621 tttcaataaa gccgttctcc cgccaagcgc cccgtccgca aagattttca tagcaccgaa 2341681 ctccacatac gggccggaca gcttctccag ctgctcccat cgatcgacag cttcatgatg 2341741 aacgagcaaa tggcagcgaa acggatactt tccgccagcg gcagctttct cataagcttt 2341801 catcggcacc gaaacatcac cataatagga caagtcttcc gaatgaccgc ccgtcaggcc 2341861 ttttgtccag caatccttta ttgcagccgt taatgcctca tcaacatagt gctgggagac 2341921 tggcgggaca gccttcagaa tcaaatcctg cgccttatca aacaggagtc cggtcggctc 2341981 gccatttgca tcttttacga tgactccgcc gtcaggatca ggagtatttc ttgaaattcc 2342041 cgctgcttga agagccgcag aattgacagc tattgcatgc cggcatatac gcttgagcaa 2342101 gacgggcctg tcaggaaaca ggcgatcaag atcatgctta gtcaagtagt caggtgtctc 2342161 aaactgattt tcattccagc cttctccaat gagccaatcg tttttaggaa gctgccgctc 2342221 tctttccttc gcagcctgta aaattgaatc tttcgacgtc agtgcggaca gatcgagctg 2342281 aagctgtttc tcaccgtggc cgatcaaatg tagatggctg tcaacaaaac cggggaacat 2342341 cactgctccg ttcaggctga tttcttctgt ttccggcgac ccgtactttt ccttcaaacg 2342401 ttcatagctg ccggtgcctt ttataacacc atcctcaaca taaactgcct cagtccgatc 2342461 gccttcttcg agcatcgtat aaatgaaacc gccgtgccat atcgccttca ttcacgttca 2342521 ctctctttct ttacgccttt ttattggctt tgagctgttc ttcacgtttt cttaattcca 2342581 ctcgtctgat ttttgcagaa gccgttttcg gcaggctttc cacaaattca atttctctag 2342641 gatatttgta tggagcggta atcgtcttca catggttttg cagcattttg acaagctcat 2342701 cactgcgttt ttcatgattt tgcaggacaa catatgcctt tacgatggag cctctgattt 2342761 catcagggct tgcgacaaca gcacattctt ttacttctgg gtgcttaaca agcgcgtctt 2342821 ccacctcgaa aggcccgatc gtatagccgg agctgataat aatatcgtca tttcggcttt 2342881 caaaccagaa gtaaccttcc tcatcttttc ttgctctgtc tcccgttagg aaataatcgc 2342941 cgcgaatttg tgttttcatt ctttccggat ctttaaaata ctctttaaag agcgcaggcg 2343001 tactgaggtg aacagcgata tcgccaacct caccaggttt gcagatttca ccgtcttcat 2343061 ttatgatctc cacctgattt cccggtgtcg gttttcccat gcttcccggt ttaataggcg 2343121 tatctttcaa aacaccaacc aaaagcgtgc tttctgtttg gccatatccg tcccgtacct 2343181 taatgccaaa gtgcttttgg aaaacatcaa tgacttcacg gttgagcggc tcacctgcgg 2343241 aaacagcgct gtgcagggca gaaagatcaa agcgtttcaa gccttcaacc ttcgccatta 2343301 agcggtattc tgtcggagtg cagcagaaaa cattgatttt gtagcgattt aaaagctcta 2343361 gatatttttc tgctttgaat ctgccgtggt acacaaaacc ggttgctccg ctgccaagca 2343421 ccgctaaaaa cggactccat acccactttt gccagccagg ggcagcagtt gcccagacga 2343481 tatccttttc agaaatgtca agccaagcgc cggcagaagt ttttaaatga gcaaatgccc 2343541 atccatgtgt atgtacaaca cctttcggct gacctgttgt cccggatgta taagataaga 2343601 aagccatatc atctcttgtt gtgtcagctg ttttaaattg gcttccgtcc gcttcaattg 2343661 ataagaggtt tttccagccg gcatcatttt caccaataga cagtgtaatc agtttgtcag 2343721 ccgtactgac atcccggaaa gcgccaataa attcggagta gacgatagcg ccttttacct 2343781 ctgcatgttc aatccggtat tcaagatctt tcgcgcgaag catttcggag cacggaatga 2343841 caaccattcc tgatttcagg atagccaaat aaacagcata ggcttcaagc acccgcggaa 2343901 ccattacaat cagcttgtct ccctttttaa atccaagatc agctaaggcc gctccgattt 2343961 tatttgtttc ttccatcagc ttttcatacg accaagattc ttgcttgccc gactcgtcct 2344021 cccaaagaag agcggttttt tgtccagcag cactgaactt ttccatttca ttcactaaat 2344081 tatattgcac aggggcaatt aaatcttcac gttttaacac gaacaactcc tcactttctc 2344141 cacccattat acataaatac aggctctttc cgtaaggata tgcctaaaag caacctctgt 2344201 aaacatagat tttataggcc gctggtcctt ttttatatgt aaaaaatgaa aaagagtggg 2344261 gataccccca ctcctaagcc attatgtgaa attgtaaatt agaattgtcc tccgcccatg 2344321 ttttgttgag caaaagatac aagacgtttt gtgatctctc ctccaacaga accgttagcg 2344381 cgagaagttg tgtctgctcc aaggtttaca ccgaattcag aagcgatttc taatttcatt 2344441 tggtcgatcg cttgagcagc tcctggtact aaaaggttgt tgctgttacc tgagttattg 2344501 ttagccatgt gtctcacctc cttgtgagta tagaatgtgt caaaacacat ggcttcattc 2344561 agaaaaactt tggtaattgt atacaggagc tgaaaattga tttaaaagag ttcagcgaat 2344621 ttatcgttag cttcttgttc gctataaagg gtcattgtct caatgttatc taccgcttct 2344681 tgaatatacg gctcgaaatc aacaaagctt tcaaagtgtt caattttctc ttttttaggg 2344741 cgtgttttcg ggcttggcgg tgtaaagatc gtgcagcagt cttcaaacgg ctgaatactt 2344801 gtctcatatg tgccaatttc ccgtgatttt tcgatgattt ctgttttgtc catggcgatt 2344861 agcggacgca aaatcggtgt tgacgtcacc gcattaattg catacatgct ttcaagcgtt 2344921 tggctcgcta cctgaccgag gctttctccc gtaataatgg caagcccgtt tctcttttct 2344981 ctgattctgt cggctatctg aagcatgagg cggcgggttg ccgtcattgt gtaattttca 2345041 ggaatttgtt tttggatgag ctcttgcgtt tttgtaaatg gaacaatatg aagtgtcatg 2345101 cttcccccaa aacgggacag acatttcgcc agatccatta ccttttgctt tgcgcgctcg 2345161 cttgtgtatg gcgggctgaa gaaatgaaca gcttctaccg acaatccccg tttcatcgca 2345221 taaaaaccgg ccacagggct gtcaaaaccg ccagaaagca tcagcatcgc ttttcctgct 2345281 gaaccaactg gcagcccgcc tgcacctttt tcatcacgaa ttgtcaaaaa tgttgcttct 2345341 tccctgattt cgattctgag cgggatgtct gggttgcgaa catcgaccgt caatccttct 2345401 gtatttcgca aaatatggcc gccgatttca gcgttcatct ggtttgtatc taattcaaat 2345461 tgcttatacg ctctctttgt cgcgacttta aacgtatcac ctggtttata ctgatctttg 2345521 atagccttta gtgcggttgc cttaatatca tcaaggcggc tgtcacactt aattgccagg 2345581 ctgaagcttt gaatcccaaa cacttgcttt aaatgaggaa aaagagcctc aggatcctct 2345641 ccatttaatg taatcgtcat acgatccctg ttggaaaagt attttaaatt cggatagtct 2345701 ttcaaaacga gtctgatgtt ttgttttaag cgctcaataa agctttttct gtttttgcct 2345761 ttggtcgaaa tttccccaaa acgaattaat atatgatcgt aattcatgtt ctacctcatc 2345821 atttccctta attttttgat gccaggacga agcgcgttca taaacggttc tgccacatcg 2345881 cttgtctggc tgtaatttaa actgattctg atgctgcttc cggcaatctg ctctcctttg 2345941 cccatctcta agagaacctt gctgggctta tgttcttttg ccgagcaagc cgatgttgtg 2346001 gagacgaata tatcctgttc ctcaagcatg tgtaaaagca cttccgcttt aatccccggt 2346061 acagagaaat taataatgtg cggcgcgcta ttcatttgag gcgtgttgat aacgacgccc 2346121 tcaatttcac tcagcctatt cataaacaat tcctttacgg cagtcatcgt gtcaagccgt 2346181 gtgtcaaaat cagcagaggc cagattaatg gccttggcaa gcgaaaccgc accagcagta 2346241 tgttctgttc cggcccgtat gcctttttgc tgagagcctc ccgttatgag cggaataagg 2346301 cgtgttcctt cttttacaat aagtgcgcct gtccccttta ggccgtgaaa tttatgcccc 2346361 gaaattgaac atagatcaat gccggccttt tcaattgcca agggcacttt atagatgccc 2346421 tgcacataat cgacgtgaaa caaaatgttc gaatgctctt tcagcacttc tcctgccgct 2346481 tcaatcggct gcacggaacc gacttcattg ttcacatgca tcatgctgac aagcacggta 2346541 tcgggacgga tggctgcttt tagatcttca atagaaacaa atccgtcttc attcacagaa 2346601 agataagtga tatcaaaccc gaacaactct ttcagctgtt ctaacgattc cgtaacggat 2346661 ggatgttcaa tagaagtggc aatgatatgt ttgcctgttt ttatctttga caaagccgct 2346721 ccttttaaag ccgcattatt ggcttctgtg gcgcctgacg taaatacaat atcatatttt 2346781 tttaggccta aggacctttt gatttgattt ttggctgctt gaagcagctg ttccgtttcg 2346841 gctccatatc ggtgcaaaga tgaaggattg ccaaagtatc ggctgctcgt ctgttcatat 2346901 acgttcaaga cttcatcgta aggcttcgtc gttgaactat tatctaaata tatcatcttt 2346961 tttactcctt tatgaaagcg gtacaaggta tgatatttat gttaccataa caaaatttaa 2347021 tagaaaatta cgaaaaacta gtattgactt ctaatttttt taccatataa taagatttgt 2347081 tcgtttcgtc atattatctg acaattaatt gacagaatat tttaacataa ttattaggag 2347141 gatttttttc atgaaacact cactgcctgt caaagatacc attattattg gtttcatgct 2347201 atttgcgtta ttctttggag caggaaatat gatttatccg ccggaacttg gacaagcagc 2347261 cggacacaac gtctggaagg ccatcggcgg atttttactg acaggggtag gcctgccgct 2347321 tctcggcatt atcgccatcg cattaaccgg taaggacgct aaaggccttg ctgacaaagc 2347381 gcaccctgtt ttcggcacaa tctttactgt cgtgctttat ttatcaatcg gaccattatt 2347441 cgccatcccg agaacaggaa ctgtttcata tgaaattggc gctgttccgt ttttgactgg 2347501 tgtaccagaa agactttctt tattaatatt tacacttatc tttttcggcg ttacgtacta 2347561 tttagcgtta aacccatcta aggttgtgga tcgagtcgga aaaattctga ctcccatcaa 2347621 attcacaatt attttaatca ttgttctcaa agccatcttc acgccgatgg gcggattggg 2347681 cgccgtgaca gaagcatata aaggaacacc ggtttttaaa ggatttttag aaggctataa 2347741 aacaatggac gcacttgctt caattgtatt tggcgttgtc gttgtaaatg ctgtaaaaag 2347801 caaaggcgtt acacagtcta aagctcttgc tgcagcctgc attaaagcag gtgtgattgc 2347861 cgctttaggc ctgactttca tttatgtatc ccttgcttat ttaggtgcaa caagcacaaa 2347921 tgccattggt cctgttggtg aaggagctaa aattttatct gcgtcttccc attatttatt 2347981 cggttcattg ggcaacatcg tactcggagc agcgattaca gtcgcatgtt taacaacaag 2348041 catcggcctt gtcacatctt gcggccaata tttttcaaaa cttattccgg cattatcata 2348101 taaaattgtc gttacgattg tcacgttatt cagcttgatc attgcgaatt tcggactcgc 2348161 gcaaattatc gcgttttctg ttcctatttt atcagctatc tatccgcttg ccattgtcat 2348221 tatcgttctt tccttcatcg ataagatctt taaagaaaga cgcgaagtgt acatcgcatg 2348281 cttgatcggt acaggacttt tcagtatttt agacggtatc aaagcagccg gtttttcact 2348341 tggatcttta gatgtgtttc taaatgcgaa tcttcctctt tacagcctcg gcatcggctg 2348401 ggtgcttcca ggaatcgtcg gagcggttat cggctatgtg ctgaccttat tcatcggacc 2348461 atccaaacag cttaatgaaa taagttaatg tcacagaacg cctgcgttat tgcgcaggcg 2348521 ttttgtaata aaaaaagagc ctgctcatta cactgcgggc tctttttcat ggtcgtgatt 2348581 atctaagcgg atatgtcagc tttgattttt tcaactgcac ctggcgcagc cttttctaca 2348641 gcggcagcgg caatttcata agagtcgtca taatcaaaag cataaaaacg tctttccgct 2348701 tctttcagct gttcagataa aatatgattc tggcttctga accggtttcc gaactgaatg 2348761 attttttcaa tgaggatgac ctgctcgaca agttcctctg attcccggct tgccctgttg 2348821 acgatatctt ctgcttgttt caaatgggct ccggcttctt ccatatttaa tggaagttcg 2348881 tttagttgat tgaccgtttc ttgaatatga tgatgcgcgt tctccagcat ctcttgaata 2348941 tggctcggaa tgcctggaat gttgctagtc ttcagcagtc ttgctgtctc agaaattgtt 2349001 tttttcaaat tgctgagcgt ctccctcgcc tgaagctctt cttttctcag cgcttgcaga 2349061 ttttcacgat actcggcatg ctcttttttc acttcttcaa tttgcttctc tattgaagca 2349121 acttcttcta ctaaaagtga gtaggcgaca tgctctgcat caagcttatc tttaacggat 2349181 gatagcagct ttccaatttc atcaaggcgc ttttcaaaag cctgctgttt gccgagctca 2349241 ccggctgtca gcctgtagct ttccttcacc agctcagttt ccgctttcgt atgctctttc 2349301 tcttctttaa gcttgtcgta agcaataatc aattcaggca ttttgcttag tacggattga 2349361 ccggcttcaa cttcgccctc cagctgctga taaacagatt gaatattttc gtcaatgagc 2349421 tgcaggattg cggacgcttc atcaatatcc agttcagtca tcaggacatg ttccgctcgt 2349481 ttcagctggt ttgacagatt ttctaattcc ttatcaagct ggatatgctc aagcttgtac 2349541 cctttttctt tcatttcgcc atagccatcc ttgagctttg caatctgtcc gggcaccgtc 2349601 tgtttacagt cagctaacag cttcggcaca tcatctatgt atgactgaag ccgttcaaga 2349661 ttgcggtcct gctcaagcag tacttttcgt gcagtaatat agtttccgcc ttctgtttct 2349721 tcttcaaatt gtttgatgcc gctccaaatt tcgtccagat ccttttcaag gctgtcataa 2349781 agctccccgt aaaggtggct gtaagccagc aggttttttc gagatttcga atagcgctcc 2349841 ctcacctgtt caatctcttc acggctcttt tcctcacttg tgacaagatc gctgatttcc 2349901 cgaagaatct tttcaatgct tgattcagcc gctgtcagca ggtcgtcgat atgaacgagc 2349961 acttgattgg cctttttaaa ccggtatttg tctgcatttt cctcggcatc ataaaggagc 2350021 tcttcaactt tcggcatgtg ggctgtgaca atctcatccc attcttcacg ccacttctca 2350081 aagaactctt ctgtctgacc cgtcattttt aaatgtttta ttttagacat ttcttccacg 2350141 atcgaccgat tcagaatttc aatcttccac gattccagcc ggtcgatttc ggcgtagatt 2350201 tttttcctga aaaagtagcc tgccgcaaac agcgcaagca gtacaattaa taatccaatg 2350261 acaaactcca taatgagccc ccttgctgtt taccttaatc tgtcagggtg ttttatttat 2350321 tcagaaagat ttcaggatat gtattgagaa aaactgtcgt tttcattgtt attatgatac 2350381 catgtaacaa acattttttg accagaaatc aaaaactttt tgtgcaaaat cggcaggatt 2350441 tgactatttt ttcatggggt gacatcaatg caaaagcgag acggacatat tcacacacca 2350501 ttttgccctc acggctccaa tgacacactc agacaatatg cagaagaagc cttaaaaaaa 2350561 gggttcgaat cgattacttt taccgaacac gccccattgc cgccatcttt taccgatccc 2350621 acgccgctga aagacagcgc gatggcgcaa gcttctttgg aacgctatat tcatgaaatt 2350681 tccggattaa aaaaagaata tcgcggacag cttagcatac ggacagggct tgaagtcgat 2350741 tatatcgctg aatttgaaga cgaaattaca ttattcctag acacatacgg gccatattta 2350801 gatgacagca tcttatccgt tcattttttg cgcacagact cttcctatct atgccttgat 2350861 tatgacgagc ataccttcaa agagctgatt tcagcctgcg gaagcattga agcggtatat 2350921 gaacaatatt accggagtat ctattcttcc attgtagcat ctctcggcgt ttataagcca 2350981 aaaagagtcg gtcacatcac actcgtccaa aaattcatca agctgtttcc atacagcatg 2351041 tcagagcata ttcgcggcct cgtttctctg tgcctgaatg ccattgaaga aaacggaatg 2351101 gagctcgact tcaatacttc cggcttaaga aaaacttacg ctggcggtat ttatatcgag 2351161 gattggatgc tgaatgaagc gaagcaaaag aagatcccgc ttgtgtttgg gtctgatgcc 2351221 catcaagcgg gagatgtcgg atatgcgtat gaggcgtttt tggaacggtg ctagttggtg 2351281 agcgccacgt ctcctgtccg gaagacgctt ctgatccaaa tcttgatttc ttcaaaatac 2351341 attttataaa aatacggctc gtgcggctgc atgtagagta cttctgaaat atattgaggc 2351401 tggagatagg gcatcatcaa gagagatttt aattggagaa taaaatgagg cagcggcagc 2351461 gttaaatatt cacgctgttt ttctccttcc tcaatgatca gctggaagat atacttttcc 2351521 ttcattagat atgtcgacat aatttccctg attaatgtgg agtcaattgt gacttcccgg 2351581 tagacaaaac gagttaattg acgatgatta tgctgatagg ataaaatatc gaaaaccaat 2351641 tgaagaagct gttcctgcgt gctttgagta gagatattgc ttgccgctgt ttcaagcgtt 2351701 ttgctgtagc cttcgtaaaa ctctgaaact aagtgttcca tcaagcctcc tttgccttta 2351761 aaatagtagg agatgtgcgc aacatttaca tcagctgact ttgcgatttc acggacagac 2351821 gtgccagaaa atcctttttg gttaaaaagc atgacagcag attcaataat tttgtctttg 2351881 gtgcttactt tcatacggct cactccttcc tcttgatact attcaagcag aaagccgctg 2351941 ttcctgtaag aacttatcga caaatgccgg cagaaaagcc ggaactttgt tttatattat 2352001 agaaaaagtg agggttttcc atgttccatg tcgaaaaaca atctggagat aaagaaaaag 2352061 actatcagct tctgctaaaa cagctcgaag ccatgaccga agacgaaaca gaccaaatag 2352121 ctaactatgc aaatgcctca gcactgctgt atcattcgct gcctgaagtc aactgggcgg 2352181 gtttctattt tgccaaagaa gaggatggac agcttgtgtt aggtccgttc caaggcctgc 2352241 cggcatgtgt tcggattcct ttcggcagag gggtttgcgg cacagcgtac gcaaacggaa 2352301 aagtggaacg tattgaggat gtaaacgcgt ttccgggaca tatcgcctgc gatgcagcgt 2352361 ctcaatcaga aattgtgctt ccgattcgtg tagacggaaa aattgtcggc gtcttggaca 2352421 tcgacagccc agtgaaaaac cgtttcgacg aaattgatga aaaatactta actcaatttg 2352481 ccgaaacgct agaaaaagcg ttagcgcagt aatataaaag cccaaaactg atatcgtttt 2352541 gggctttttt tattttattg agtcatgaat catcaagcgg tttttcccgc tccgtttcgc 2352601 gctgtagagc gcttcatctg cctcatgcac aagctctttc agcgactttt ttgtttctgt 2352661 cgtccagcag gagataccgc aggaaatggt tacctcgggt ttcgtatttt ttctgaccgc 2352721 gtaaaccagt cgctcggtaa tccgtttccc cactgcaacc ggcacatttg gcaaataaat 2352781 cgccagctcc tctcctcccc agcgggcacc gacatcatgc tttcggatgt tgcttttaat 2352841 cactgaagcg acttgaatta aaatctcgtc cccagtctga tggccgtacg tatcatttac 2352901 atttttaaaa ttatcaatat caacaagaat aaaaacaccc ttttgatgga ttttcatgct 2352961 gtattgaatt ttttcatcta aatacgctcg tgaatacagt tcagtcagct gatctgtttt 2353021 cacgagatgc tcaaggcggt cgcgaagcat tgaattggtt acagccagtg tcgcgtgatg 2353081 aatcagcgcc tgaaacagct tgtacatttc aaatgtaaaa gcgtacagct cctgtttcaa 2353141 taaaaccgca aagcctaaaa gccggtcgtt ttgaatcatc ggagcagcca tcagcgagcc 2353201 gtaccccgcc ttcccaaaaa cagactggcc attcccgatg aaaacccctt tttcaccttc 2353261 atacagcttt tctttcagct cattataaaa atctgacggc ttcgcttctt taaaaaatgc 2353321 tgtgctgcct gggagcaatg ttaggttttc aaaatggtct atatgaaaaa atcccacttc 2353381 ttctgcctga aacgattctg ccattctcac agccagatca ttcattgtat cagtcaatgt 2353441 cagccgctga ttcaggcgtc gtgatgtttc attaatcaat tccaaatttg cgatgcttgc 2353501 tttggattgt tcgtagagct gggcattttc aaacgctttt cccgcggcgt ttgctaacag 2353561 cgacatttca tcaaggcagg catcagtaag aaagctgtca cccgttcctt cagccttcaa 2353621 caccccgtat gtgccctgct gtcctttgat cggaatatag gcgacagatt catttttccg 2353681 caaaatgtct ccggacaaat acactttgag cgcaaaggaa tcggattttt ccccttccat 2353741 atacagctct tttgcaggaa tccctaaaca ttggtcttga tcgtgcgata taaataaaga 2353801 aaactcaaaa agagaaaatg tgcttgtcaa gctttctaaa agctgcttca gcacatctgt 2353861 ctgatcaagc agtgaatgga acagctctgt cattttgtat atcttttttt ggtagatcgt 2353921 tttgttatag agtctttcct gtttcatcga ctggtttaaa aatgaagcaa ccacgtccgg 2353981 aagcccttca ggaatctctt catcctgcct gcacgcaaga tggaaacgcc tgccggagcc 2354041 gtcctcaatc agataacatg aagcgtttat ttttgaagcg gaaaaacgcg cttcaccatc 2354101 tgccagtttt gtcacaaagt ctgatggtga cggtgtaagc gaaacacaaa gggttgaaaa 2354161 ataggtttga atagccgaag tcagccatat gaaagagtcg gtgaatgtga ctttttcaga 2354221 tttggttaat aaaaaatcga gcatatgata atgaaaggcg gataattgat ctttagtttg 2354281 ttctaccatg tttttatcac ctaaaagttt accactaatt tttgtttatt atatcataaa 2354341 cggtgaagca ataatggagg aatggttgac ttcaaaacaa ataaattata taatgacctt 2354401 tgtgtgaaat attgcagcct ttttgttcag cttctatgtt ttcattttgt tccttatcaa 2354461 taaggtgtat cgtgtaactc tctgctgctg gagcgaggat acatgaaaac aaaatgtgca 2354521 tggtcgaata gagcagacgg tttttatttt ccacaaaaat aaaaccaaag gaggagtcac 2354581 attatggctc gctatacagg tccatcttgg aaactgtccc gccgtctagg aatctctctt 2354641 agcggtacag gaaaagaatt agaaaaacgc ccttacgctc caggtccaca cggcccagga 2354701 caacgtaaaa aattatcaga atacggtttg caattgcaag aaaagcaaaa gcttcgtcac 2354761 atgtacggtg taaacgaacg tcaattccgc actttgtttg acaaagctgg caaactagct 2354821 ggtaaacacg gtgaaaactt catgattctt ttagattctc gtcttgataa cgttgtgtac 2354881 aagctaggtt tagcacgtac tcgccgtcaa gctcgccaat tggttaacca cggtcacatt 2354941 cttgtagacg gaagccgcgt tgacatcccg tcttacctag tgaaacctgg tcaaacaatc 2355001 ggtgttcgcg aaaaatcaag aaacctttct atcatcaaag aatctgttga agtgaacaac 2355061 ttcgttcctg aataccttac tttcgacgct gaaaagcttg aaggtacttt cactcgtctt 2355121 cctgagcgtt ctgaacttgc tccggaaatt aacgaagcgc ttatcgttga gttctactct 2355181 cgttaatcgt tttaaaaacc cctgccgcta tgcggtcggg gtttttttat cggctttcgc 2355241 ctcttgctgg ccaacactat cttgcgcctg ctgctcccaa tgatcccgct gcagccgttc 2355301 ttttgcaatc gtacacatga gattcacgct ttagcgctcc tttcatttaa aaggtggtga 2355361 ttggtcgtgt ttgccctatc taatatactc ttttcctttc attcctatgc ggtaaacaaa 2355421 aagatccttt gccttcagtg gcaaaggatc tttttcttat ttatacgtca caaggaagta 2355481 ttttttcttc ccgcggcgca gaacagtaaa ttggttttcg atgcggtctt cacctgatag 2355541 ggtataattt atttccgtct ggcgttcacc gttaatgtaa acagctccgt tttggatgtc 2355601 ttcacgcgct tggcgtttag aaggagataa tttagattgc accaacacat ctacaagtga 2355661 aagctcttgg gtgctgtcaa cttccataga aggaacatct ttaaagccta cttttacgtc 2355721 ttgagcagaa agctctttaa tattgccgct gaacagcgct tgggagatgt tgatggcttg 2355781 ctccagcgcc tcgcgtccgt gaacaagtga tgtcacttct tctgccaggc gtttttgcgc 2355841 ttcacgtttt tctggcgccg tttctgtttt ttcagcgtat gcttcaattt cctcttttga 2355901 aaggaacgtg aagtatttca agtatttgac aacgtcacgg tcgtctgtgt tgatccagaa 2355961 ttgatagaat tcatatggcg atgttttttc tttatcaagc cagatcgcgc cgccttccgt 2356021 ttttccgaac ttcgtgccgt ctgcttttgt gacaagcgga atcgttaggc caaacgcttt 2356081 tgctccttct tcttctgatt ttctgatcag ttcaagaccc gctgtgatgt tgccccactg 2356141 atcgcttccg ccgatttgca gtttacagtt tttgtctctg taaagattta agaaatcata 2356201 agattgaaga atcatgtagc tgaattccgt gtacgagatg ccggattcaa ttcttgagct 2356261 gaccgtatct tttgccagca tgtaattgat gccgaaattt ttaccaacgt cacgaaggaa 2356321 atcgatcaca ttcattttgc cgatccagtc aaagttgttc gcgatgacag ctgggttttc 2356381 tgctgcttca aaatctagaa atctggacag ctggtttttg attttttggg accattcgga 2356441 tacgatgtca gcagtgttta atgtacgctc tgcttttttt ccgcttggat caccgatgag 2356501 gcccgtcgcg ccgcccacaa gcgcaatcgg atgatgccct gcaagctgaa aacggcgaag 2356561 tgttaaaata ggcagcaggt gtccgatatg caagctgtct gctgtagggt caaagcctga 2356621 gtacaagcgg attttttctt cattcagctg tttatttaac ccttcttcat ctgtcatttg 2356681 ctgaatcaat ccgcggaagg ataagtcttc aagtaagtta gtcataagat aaagctcctt 2356741 ttttaattaa aataaaaaac gccccttcgt ttacacgaag ggacgattga ttatcgcggt 2356801 accaccctac taataagaga atgcaaacat tcgtcttatc actttgcctg ataacggatc 2356861 aggtccgttc tttcactact gaaagcctgg ccggctttgt ttgcaaaagc ggttcatgag 2356921 tgtattcgat atatccgtct gtgctgattt tcaccggcca tcagctctct ggaacgtaag 2356981 gatattctac ttgtctcaat ctttaccttt tcatatgaag ctatatcatt tttaacataa 2357041 ataaaatcct gtgtcaacgc cgccttttaa tcctccattg ttgacagatc tccagccggc 2357101 agattaagct cccatgcctt cagcacgcgc ctcatgatct ttccgcttct ggttttcgga 2357161 agcttatctt taaattcgat ctcacgcgga gccgcatggg ctgcaagacc ctgctttaca 2357221 aataggcgga tctcttcttt cagtttatca gacggctcaa atccttccct gagtgcaata 2357281 aaggctttaa tgatttctcc acgcaccggg tcaggctttc cgataacgcc tgcttctgca 2357341 atagccggat gttcgacaag cttgctttcc acttcaaatg ggccgacgcg ctcaccggag 2357401 gtcatgatga cgtcatcaac tctgccttgg aaccaaaagt atccctcttc atccatgtaa 2357461 gcagaatccc cagacacata ccagccgccc ggcatgaaat acgattcata cttttcaggg 2357521 ttattccaaa tggtatgcat catggaaggc cagccctttt tgatggcgag attgcccatt 2357581 cggtacggcg gtagctcgtt gccttgattg tcaacgatcg ctgcctccac tcctggaatc 2357641 ggcttaccca ttgaacccgg tttaatatcc atgcaaggat agttgcagat gagctgactg 2357701 cccgtttcgg tcatccacca ggtatcatgg attcgtttgt taaaaacttt atgtccccat 2357761 ctgatgactt ccggatttag cggctcaccg acactgagca catgccggag tgaagttaga 2357821 tcatatttcg cagccatttc atctcccgct cccatcagca tccgaaaagc tgtcggcgcg 2357881 ctgtaccaga cattgacgcc aagctgttca atcgttccat accagctttc cgggctgaaa 2357941 cgtccgccga cgatgacatt tgtcgctccg ttcagccacg gtgcaaaaat gccgtatacc 2358001 gtacctgtca cccagcctgg atcagccgtg caccaataaa tgtcttcttc ctttaaatca 2358061 aggacccact ttcctgtttg atattgctga atcatcgctt catggacatg caacacgccc 2358121 tttggcgtac cagtggaacc tgatgtatag tgaagcagaa agccgtcttt tttatccatc 2358181 cattcgatat ccaatcttgt gctttcctgt ttcgctgctt catcataatt gatgatattc 2358241 gtgccgctct cagcctctcc cccgactacg aagacatgct gcaagtgagg cagtttgtct 2358301 accggtattc tctccagcag ctcaggcgtt gtgacaacaa cctttgcctc actgttttca 2358361 agccggtctt tcaccgctcc ctccataaat gcttcgaaca gcggcccggc gatggcgcca 2358421 attttgattg cgccaagcat aataaaataa agctcgggtg atctcggcat aaaaataaaa 2358481 acgcggtccc ctttttccac atttccatac cgtctcagca cattcccggc tctgtttgat 2358541 tcttccttca tttctttaaa tgtgtatttt tcatcccttt ttgcgtcttt ataataaagc 2358601 gctactttgt tttttcgaaa cgattcggca tggcggtcaa tcgcttcata cgccgcattc 2358661 agtttccctg tctcatgcca agagaaatgt ttctctgcct cggcccaatc aaaatgccgg 2358721 tacgtttctt catagttttt taagttatga tccccctcta ttgctggtaa cgctttcaag 2358781 ttcatgccca aacatccccc tttgctgaag ttgtcacaat tattatagta tatattcata 2358841 ttcttctcaa tttttaaaat ataaaccatg ttgaaaacgc tttataattt ggtattctta 2358901 aagaaggcat gtatttttga taagaattga tgggacggtg aattagtgga acatcataaa 2358961 acataccatt cagcaaacat caaaacagca accggctctt tactgataga agggcctgtc 2359021 tctccagagg atttggcagg ttatgagttt cataaagatt taaccgcatt tcgcccgcct 2359081 cgcgagcagc atgaagcgct agtcgacatt gcaggccttc ccgaagggcg cattattatt 2359141 gccagagacg gccgaaccat tgtcggctat gtcacgtatt tatatcctga cccgctcgaa 2359201 agatggtctg aaggaaatat ggaggatttg attgagctcg gagccatcga agtagcgccg 2359261 gactatcggg gatgcgctgt cggaaagacg ctcctgaccg tcagcatgat ggatgaacaa 2359321 atggaaaact acattgtgat gacgacagaa tattactggc attgggattt aaaagggatg 2359381 aaaaaagatg tgtgggaata cagaaagatc atggaaaaga tgatgaatgc aggcggattg 2359441 gtctggtttg caacggatga gccggagatc agctcccacc ctgcaaactg tctgatggcc 2359501 cgcattggaa aaaacgtcag ccaagaatca attgagcaat ttgacaggct ccgtttttat 2359561 catcgttata tgtattaact gacactgaca aaggggaaaa aataatgatt gttgagcaaa 2359621 tcatgaaaag agatgtcatt acattaacga agacggatac gcttgaaaca gcaatatgca 2359681 aactgaagga attccatatc aggcatctgc ctgttgtaga tgaagaacga cacgtgatcg 2359741 gcatgattac agacagggac atgaaacagg ccagcccgag tatttttgaa gaaaacaaac 2359801 gaagcctatt tctcacacga agcgtagatt caattatgaa aaaggatgtt gtctgcgccc 2359861 acccgttaga ttttgtcgaa gaaatatcag ccgtgttcta cgagcatggc atcggctgcc 2359921 taccagtggt acaccatcaa aaattaatag gcattttaac aaaaaccgat ttgctgcgga 2359981 cgtttgtcaa attgacaggc gctgaccagc cgggctcgca aattgagata aaagtaaacg 2360041 acatcaccaa aagcctcgct gagatcagca gtctttgcca agaccttcaa gtgaaaatat 2360101 taagcgtgct tgtttatccg catgacgatc ccggtgtaaa agtgcttgtc ttccgtgtaa 2360161 aaacgatgaa tccgctgccg tttttgcagg cattacaaag aaatggacac cacgtcgtat 2360221 ggccgtcaga gcaaagggat ctgctatgag agacagtgta tttatctatt ctccatccta 2360281 ccaaacctat atgtttcatc aggagcatcc ctttaatcag cagcgggttc tgttaacata 2360341 tgatttgctt aagacgatca atgcctttga tgatggagac attgtcaccc ccagactcgc 2360401 ttcagaagag gagctttccc ttgtccacac ggacgattac attcaggccg taaagcttgc 2360461 gggcgccgga aagctccccg ctgaagaagg agaaagctac gggctcggca ctgaagacac 2360521 acccgtcttt gccggcatgc acgaagcggc atcactcttg gtcggcggca ctttaacggc 2360581 cgcagactgg gtcatgtcag gacaagccct gcatgcggca aaccttggcg gagggcttca 2360641 tcacggcttt cgcgggagag catcaggatt ctgcatatac aacgacagcg ctgtggctat 2360701 tcaatatatc cagaaaaaat atagcgccag agtgctttat attgatacgg acgcccacca 2360761 cggggacggt gtgcaattta cattttacga taatcctgac gtatgcacgc tgtccattca 2360821 tgaaacagga aggtatttat tccctggaac cggtcagatc caagaaaaag gaagcggaaa 2360881 aggatatggc tattccttta atattccgct tgacgctttt acagaggatg attcttttct 2360941 tgaggcttac cggacagcag cttcagaagt cgccgcgtat ttcgagcccg atgtcattat 2361001 cagccaaaac ggcgccgatg cccattacta cgacccgctg acgcatttat cagcaacaat 2361061 caatatatac gaagaaatcc cccgtcttgc acacactttg gctcatcaat attgcggagg 2361121 gaaatggatt gcagtcggag gcggcggata tgatatttgg cgtgtcgtgc cccgcgcctg 2361181 ggccagaata tggcttgaaa tgaagggaat tgacccgggt cacgagatcc cgccggaatg 2361241 gattgttaaa tggcaaaaac aatgccccgt ggcccttccg tcgagctgga gcgatccggc 2361301 tgatttatat cctccgattc cccgcaagcc tgaaattaca gaaaaaaatg cccaaactgt 2361361 cagcaaagca ttatatgcga tacgttctga acagcaaaga acaaagtaaa aaacgacctt 2361421 tacgaagagg tcgtttttga ttttttaatc actatttcca cacgccgatt ttccttcatg 2361481 tgttcatttg tcttgttatc ctttactggc tttgtatccg cataaccgac agcaataaag 2361541 cgcttggagg gaagcttctc tttagacgtg aagtattgaa tcactccact tgcccgtgct 2361601 gctgatagct cccagttcga cgggtatcgg tatgtcgaaa tgtttcggct gtctgtatgt 2361661 ccctcaacct gaatgtcatt tggaattgtt tgaagaagaa cggcaatttg gtgaagaagt 2361721 gtttcggcat ttttcagcac ctttgcctca cctgtatcaa acagcacagc ctcctgaaga 2361781 acgagcacga caccgcgttc atcccgtttg gctgtcattt gggccttcaa atgattgtct 2361841 tttatatatg tatttacttt cttgagaagc tgatcctgct gatcctcttg cttcttcgta 2361901 tcagatgggg atgtattctt tttttctatg gatgtttggt ccggctgaag cccgttgcct 2361961 tccttctgga tcgagtccac tgccgctttg aatttttgca gatcgatttg ggacatcgaa 2362021 aagagtaaaa taaagaacac aaggatcaag gtgatcagat ctgtaaaggt taccatccag 2362081 ctggatgaag attgactgtt ttttccgctt ccattccttc tttcaaaacg ttctcttcta 2362141 agcttcatgt acagatccct tttttgtttt tacttgtttt ggctgcttct gccattcttc 2362201 ccgtgagctg aaaacgacca gctggctttc aaggttgcgc gggttttttc cggattgaac 2362261 accgataatc ccttccacca ttacctgctt gatgaaaatt tcactttctg ttttctcttc 2362321 aagcttagcc gcgatcgggt tgaagaccat atttgccagt aatgaaccat ataaagtcgt 2362381 cagaagcgca atggccatgt ttggtccgag catatgcggg tcgtttaagt ttttgagcat 2362441 cagcacaagc ccgacgagtg ttccgatcat tccccatgcc ggagcgaatt ctcccgcttt 2362501 ttcaaaaact cgccgccctt ttcggtgccg ttcctccatt gctgcgattt ctgaatccat 2362561 gacgagccga atcgtttctt catcccagcc gtcaatcgct aaaagcagcc cttttttcaa 2362621 gaatggatct ttgatttccc gagcctgatc atccaatgat aaaagcccgt gttttcgcgc 2362681 gtgatcggaa agggaaacaa aggttttcac aagatctttc acattgtctt cctggcggat 2362741 gaatgcctgc tttaacacag agggcgcttt tttcagctca cttggcggaa aactgataaa 2362801 aacagcggcg caaagtcccc ctgttacgat gaagaaagag gtcagatcaa gaaaagagcg 2362861 gaaaccgctt actcccgatc ctgaaataat cccgataaca ataataatcg ttcctaacac 2362921 aaatccaaca ggtgtaagat aatcaaaacg tttcatcatt tctccccatg aaaaaagcaa 2362981 gaattcacca taaaggtgaa gcttgctctt tgtttttctt atgacttggt tgactttcta 2363041 agctctatac ggtgcggcag ttcgacgata tgctcttcaa ccggctcttt attcatgagc 2363101 ttcgtcagca gtctcatcgc aacggcgccg atatcatatg tcggctgaac aactgttgaa 2363161 agctgaggac gaaccatgag gcttaatctt gtattatcaa aaccgataat gtcgagatcc 2363221 tccggaatgg ataagccctg atcctgagcg gcatggataa tgccgagtgc catttcatca 2363281 gttgcagaaa gaatggctgt cggtttttta tccaggctca tcagatgctg cagtgcttcg 2363341 agtccggaat catatgtgta atccccttca gctacaaatt gttcattaaa cggaaggttc 2363401 gcttcttcaa gcgcacgttt gtagccttgg agttttttcg aacggttgat cggttctgcc 2363461 attggtccgg aaacgaacgc gatgtctgta tgtcctttat caaccaaaag cttcacggca 2363521 tcataaatcg cctgttcgta atcgatagcg actgacggtg tttcctcctg ctcttctaca 2363581 gaagcggcaa gtacaatcgg cactggagaa cgcttaaatt ccgccacatg ctcgtccgta 2363641 atgtttccgc ccataaacac gatgccgtcc acttgtttgc cgagcattgt gtttaacaag 2363701 tgcagctctt tctccatgtt ttggtcagag ttgctcaaaa taatattgta tttatacatt 2363761 gtcgcgatat cttcaattcc gcgcgcaagc tctgaataga aaatgcttga gatatcggga 2363821 atgatgacac ctacagttgt tgttttttta cttgccagcc ctcttgccac cgcgtttgga 2363881 cggtaaccga gacgttcaat ggcttccaag acttttttcc tcgttgtcgg ttttacattc 2363941 gggttgccgt tcacgacacg ggaaacggtt gccatgctta cattagcttc tctcgctaca 2364001 tcgtagatcg taatattgct catcctaaaa ccactccttt tactggatac acttatcctt 2364061 atctatagca taaacacttt atgtagagaa atgtcataat gtccgaattt atgtcgttta 2364121 tgatttgtaa gcgtaagtca gtagtgtaca ttatttttca ttattcatca aatttaatta 2364181 cttctcatga aattatacac gtttttatag atgatgaaaa cgtatacttg gtttttataa 2364241 ctaaataaac gagaaagcat aaaaaaaggc cgcaggcgcg gccttttgga ttgttcaatt 2364301 aagcgttgac tttcaccatt ggcttcagtt cattcagcca tttttcgaat tcaggaatcg 2364361 ccatttgctg agcagagtca gaaagtgcga ctgacggatc agggtgaacc tcagccatta 2364421 cgccatcagc accgatcgct aaagcggctt tagctgtcgg aagcaagagg tcacggcggc 2364481 ctgttgaatg cgtaacatca acaaagactg gcaaatgcgt ttcttgtttc aaaatcggca 2364541 cagctgaaat atccagcgtg tttctcgttg ctgtttcata tgttctgatt ccgcgctcac 2364601 aaaggataat ttggtcattt ccttgtgaca tgatgtattc agcagcattg atgaattcag 2364661 agatcgttgc agcaagaccg cgcttcagaa gcactggctt tttcacggcg ccggccgctt 2364721 tcagcaattc gaagttttgc atgttgcgcg ctccgatttg aatgacatca atgtagtcca 2364781 gcgcttcttc gatatgagcc ggagttacga tttcactgat aaccgccaga tcaaattcat 2364841 ccgctacacg ttttaaaatt tgaaggcctt caacaccaag cccttggaaa tcgtatgggc 2364901 tcgtacgagg cttaaaggct ccaccgcgca aaattttaat cccttgtttt ttcgcagctg 2364961 cagcgacttc agctacctgc tcatagctct ctaccgcaca tgggccgaca atgaatcttt 2365021 gctggccgtc tccgattttt tcgcctttga tatcaacaat tgtatcttca ggttttttct 2365081 tgcgggagac aagcagcgct ttgctgtgat cttcttcctg aagctctaaa ccggctttga 2365141 atatctcttt aaaaatgtgc tggatggttg aattttcgaa cggcccgtca ttgttttcaa 2365201 tgatattgtt taacattgtg cgttctctga cagggtcaaa tcggttgaca ccctgtgctt 2365261 ccttcgcttt accgatctct tttacaacat tgccgcgttc gttgattaat tttaaaattt 2365321 gtaggtttaa ttcgtctgct ttctgcctta aaagctctaa ctctgtgttg ctcatttttt 2365381 tcatcctttc cctgcacatt cattttttat tttgtagtta tcatgcatct tactataagt 2365441 aattccaaat ggaaatactg aaatacaaaa aattttataa aaactctact ttattaccca 2365501 aacgctttta agtgataaag taatctatga agctatccta catgatgtga gggcaatgtt 2365561 caagggtttt ttacaaaaaa aagcgccaga tgatatctgg acgctttttt ctatgacaaa 2365621 tgctgctcaa tagcggcttc tgtaatttgt gaatgtgagg tatgccattt cacttcaccg 2365681 ttctggatga tgaatatctg agggctttca tgcttgaccc catatgtttc tgcaatgaaa 2365741 ttggacagcg gccgggcttc ttgtacttga agatagtaag ccggcacatc ctcatgctga 2365801 tttgcaaagg catcaaactc atgaaatgct gcctggctga tcgggcatgt ggtgctgtgt 2365861 ttcaagaaga cgaaaacgcc ttcctgttct gcaatccgtt taaattcttc ctcagattga 2365921 ataagctgtt tagccatgac tcaagctctt ccttccctgc tcagcgattc aactgctcag 2365981 cctgtttttg tgcatctttc agttcgtctt ttacatcttc tttcgtctgg aggacttgat 2366041 cttttgtttc atcagctgcc tgcatcgctt cttccctcat atcttgcatt gcagtcgatg 2366101 aatccgtttt gtcagatttg gaacggtctc tcaaatcctt taccttgttc atgatctgtc 2366161 cagactgatc cgctacaagc tgtgtgatgt tggaagtttt gtcttttgcg atgctgacat 2366221 attgcgtgcc tttttccttc gcatctgccg tcattttatc agttttgtcc cgtaaggcaa 2366281 cagcctggct gccgagatcg tcgcgaagtt ctttgcctga tttaggcgct agaaaaagag 2366341 ctgtagtggc accgatgatt cccccgatta aagttccgat taaaaaatct ttactattaa 2366401 ttccatcttt gctcatcatt attcctcctc ttagtatttt tttctcttac agggctgatt 2366461 ttttcttttg cttccatttc tcccaaattt ccattgctgc ttgactccaa gtgacaactt 2366521 gattgatctt atcttgattc tctctaactg atgccgatac agaccctgcc gcttgtttca 2366581 tggatgtatt gaactgctgt acagaagctc ccactccttg aacagcatga acgaccgtgt 2366641 tcagcttttc tgatttttcc tgaatatctt cagccaggcg gttggtctta tgtaaaagct 2366701 cggctgtttc agttgtgatg cccttcattt gtccctccag cccttcaaga gtggatgcga 2366761 cgttttttag tgtcagctgc agtgacttca atgttttaga caagtagatc actaatacga 2366821 gaaatgcaac tgcgatgagt gcaacgctca aataaagaat aataatcatc tcaaacctcc 2366881 ttgctgcagg atatactgct gtttacccgt tttcttcaat cataaacatg tgtactgggc 2366941 tgtatacata ctattctccg ttatgtaaga aaatccttta ataagctttc ccatcagata 2367001 aataaaaagc agtgagatca ctgcttttta ttatgccatg acgttttcgt aggctctcat 2367061 atatttttgg atatctcctg ctcccatgaa gatgagaacg gctttatcat gagcttttaa 2367121 aacagatgtg tcatcttctt caatcagctt ggcattatga atttttccct ggagatcacc 2367181 gatcgtcagc tttccggcat tctcacgggc tgagccgaaa atatcgcata aatacacaca 2367241 gtcggcgccg ctcaggcttt ctgcaaattc gtcaaggaac tgctgcgtcc gggtaaatgt 2367301 atgaggctgg aataccgcga caatttcccg atcaggatac ttctgtcttg ccgcctcgat 2367361 tgtcactttt atttctgtcg gatgatgggc atagtcatca atcagcactt gatccccaag 2367421 ctgcttctca ttgaatctgc gtttgacgcc cccaaaggat ttgagagcat gcttaatgat 2367481 gctggaatca atttcttcat aatggcataa cgcaatgacc gccaatgagt ttaatacatt 2367541 gtggtggccg tacgcaggaa tataaaacgt atcatagaac gtattgcgga caaagacatc 2367601 aaaagttgtc ccttccgtgc tttttacgat gtttctggct tgaaaatcat tttcttcccc 2367661 cgtgccataa tacacaaccg ggacgttcgc atggattttc ggcagatgct catcgtctcc 2367721 gcaggcaata atgcctttgt tgacttgaag agccatctct tggaaagcgt caaatacatc 2367781 gtcaatgctt gagaagtaat cagggtgatc aaaatcaata ttcgtcataa tcgcataatc 2367841 tggctgatag cttaagaaat ggcggcggta ttcgcacgct tcaaacacaa agtattcgct 2367901 gttttcattt ccctggcctg ttccgtctcc gattaagaaa gacgtcggtt ttgcgttttg 2367961 gatcacgtga gccagcagac ccgtagtcga cgttttgccg tgtgcgcccg taacggcaac 2368021 actcgtgaat tttttcatgt agtcgcctaa aaacttatga taacgtatca ccggaattcc 2368081 ctcagacatc gctttttcta tttcaggatg cgtgtctggg aatgcgtttc cggcgatgac 2368141 tgtcatgccg ggtttaatat tttccgcgct aaaaggaaga atcgtaatat ttcttttttc 2368201 aagcgctgtt tgcgtaaaaa taaatttttc gatatccgat ccttggacag tatatccatt 2368261 atcatgaagt atttgggcaa gcggactcat accggtccct tttattccaa caaaatgata 2368321 aacagtcata attgtacctc caacaaacgt ctatctgttc cccagtatat gacgctcatt 2368381 tcaatttgcg accgcggcgg ctgaaaagcc tcccttagcg gcgtatttta tatgttttgt 2368441 tatgtttagt atcaggttat ttctttccga ttaaacccag atatcaagat ttgtctatgc 2368501 acagctgctg taaagcggca tagctgttaa atgctctaaa cactatcata ccatgtttgg 2368561 tgtgaaaatg aacccatatt attcgtttat taaatcactt gctgtgatca gcacctctcg 2368621 aggcttgctt ccttttgcct cagagatcat gccttccgct tccatcatgt cgatcagcct 2368681 tgccgcacga ttgtaaccga ttctgaatct tctttgcagg cttgaagtgc tcgcactgtt 2368741 ttgctctaca acaaactcac acgcttcgta aaacagttcg tcctcttctt tcagggcaga 2368801 tccttgtctt acgagctctt cttgttcaaa taaataggtc ggcggcattt ggcttctgac 2368861 gtgggaaacg acgcggtcga tttcccggtc tgacacaaag ttaccttgca gacgaaccgg 2368921 ttttcccgag ccgttttcca aaaagagcat atcccctttt ccgagaagct tttctgcacc 2368981 ggctatatca ataattgttc gggaatcaac ctggcttgag acagaaaagg cgattctcgt 2369041 tgggatattc gccttaatca gacctgtaat gacatcgact gacggacgct gagttgcgac 2369101 gagaagatgg ataccgcacg ctctggcttt ttgggcgatc cgcgcaatgc tttcttccac 2369161 atcgtttgga gccaccatca tcaaatctgc aagctcatca ataatgacaa ctaaatacgg 2369221 cagcttttca cccatttggt gttcagcggt taattgatta aagcggtcaa tgtcgcggac 2369281 acctgaatgg gcaaaaagct catagcggcg ctccatttcc tcaacgaccc atttcaaagc 2369341 agccgtagcc gctttagcat cagtaatgac cgggctgacg aggtgaggaa ttttattgta 2369401 aggggccagc tctaccattt tcggatcaat cagcagcacc tttacctcac tcgggtcagc 2369461 tttataaagc aggcttacta atattgtatt gatgcatacg ctttttccgg agcctgtagc 2369521 gccggcaatc aagccatgcg gcattttctt caagtcgata acaacaggat ttcccgaaat 2369581 atctaatccc agcgcagctg tgagcggtga cttgcttgtc ctgaaagctg agctgcgaat 2369641 catttggcgc aaatcaacca ccttgctcgt gcggttcggc acttcaattc cgatcgtgtt 2369701 tttccccgga atcggcgctt caatccgaat atctttagct gagagactga gtttaatatc 2369761 atcggacaag ttggtgattt tattcacctt tacacccggt tcaggatgca cttcaaatct 2369821 cgtgacagac ggaccctggg ttacatggac cacattggcg cggacattga aatttttcaa 2369881 ggtcaaatca agaagctgac gctgttcttc gatccacgca gtatcatctt gaacctgcgc 2369941 tggcgggaca tcaagcagtg caacattcgg aaatacatag ctgccgcggc gctcctctgc 2370001 tttttgctgt ttatgcgtat ctcttttcag catcatcaca ttaaaaggaa cggatggccc 2370061 tttttgagaa gatgcgcttt gttcagtcct tttctcctgt acaccaggcc tttttttcgg 2370121 ctcttctgaa gcttcgcgag gtttgtctgc gcgaatttcc tgccggtttt caagagttgc 2370181 agtagacgat ttggaaccct gctccatgtg ttcagttttc tcaagctctg tatggctgtc 2370241 tggctgaaca tctatcttcg tttcctgagc ctctcccagg gtgtcataat gattatttat 2370301 tatgctttct gatggctctt ctgattcttt tgccacagtt tctgcttgag ccagagcctc 2370361 tgatgaatac tcatgatcag taaataaagg ctcttcctga cgaatgtcca tttgttcttc 2370421 ttgaacgaac ggggactcag caccttctgc cgcgttttca tgatgattgt atactgggct 2370481 gtctgacggc tcttttgctt tttcatcctc agatactgcc tctgtctgag attcaggagc 2370541 tgtttgctct tcatcaagtt cagcggagaa aacaggctct tcaaatttct ctggctgctg 2370601 ctccctttgt tcttcctcag ccgttgcagg ctcttcgcgg cctacttcac tgtctgaaag 2370661 cccttcagcc gccgtatctg tgagcatctc aggcggtgtt tgctcttcgg cttgttcagc 2370721 tgggaagaaa ggctcctctt tttccggctg ttgaacgcct gactcaaatg gcactttgtt 2370781 acctgacggc tcggctggcc gtttcgccag cgcctcatca tgctccgtat cctttctgtt 2370841 taaaacgcca gaaggctgtt tttcaaattg ggtatccggg aagaaaggac tttctatttt 2370901 ggaatgcgcc tgtgtgtctg aagcaggata gccgcgttca cgttcgatct cttctgacag 2370961 cagtgttacc ttctctttta ccgatttatc cggttcgttc aatgtttcag aaggcttttt 2371021 cggcacatcc tttttaacag atggtttttg attgaatcca tagacaggcg aagggatatt 2371081 tgtcggttta aacggtttct tcgccggctc tgctgcttga tatgtatgct gctcttcttc 2371141 atttctggga cgctctctgt aaggtgcagc acttggacga ggcgcggatt tcggttcgtc 2371201 cgatggtgtg cggcgccttc tcaggtcatg atttttgtat ccgtcaggca cgactggaaa 2371261 acggaatttg ccttttggat attcataata tattttagga tcttccaatc tttttaattg 2371321 tccttcagga tgatgtactt cttgttgctg cggaatttga gcgggttttg tctcccgttc 2371381 agcatcctct tcgctttcgc ctaaaaacaa atcaaaaaat ttatgaagcc aactcataat 2371441 ttatctctaa ctcccttata gttttctggg acggttttta gtataccact gctggtcggc 2371501 ccagaaaaga ttaagctatc agcagaaaca aagccgctaa acaagggctt agcggctttt 2371561 cacatgattc gttttttttg gcggatttat gggagtctaa aactgaaatg cgtctcccgc 2371621 ctcatagtct ccttctaaca caaggattcc tttttcagca ggggcatccg gcaaatcaag 2371681 ctctttcgct gagcagatca tcccgcttga cggaacgcca cgaagctctg catccttaat 2371741 gacaagtccg ctaggcatca cagcaccgac tttggcaacg acaacttttt ggccttggtc 2371801 aacgttaggc gcgccgcaga cgatctgaag cgtttcttct cctacgttga ctttacatac 2371861 gcttaattta tccgcattcg gatgtttttc ttttgattct acataaccca caacaaactt 2371921 cggagataaa tcaacgacta atgtttcttc aacgccgttt ctgtttaaaa tctcattcac 2371981 atcttgcacg aatgtttctg agagcgcaac agggccgttt tcatcaatgg tcaagtaaga 2372041 agacgcattg aaaatgttga agcccgttgt ttcttttgtt tcgttattga aaattttgac 2372101 gacgtcgccg tgtttttcat agcctaattg ttcgcgtgtc acatcttgaa gagagatcag 2372161 gagcgtgtct cccacacctt ctttattata aaaagcgttc ataagtaaaa atcctttcta 2372221 atcctttttc ggacggcttt tcgccaggat aaacaccggt tccagctttc cttcattgta 2372281 caaaaatgat agggcggtaa tcgggacggt gccgcctgca aagaagctca tcgacatttg 2372341 tcctagaata tcataccccg attcattccg gatgtcagca agaatcaaaa cgtcctgatg 2372401 aggaacagag atcgccagct caccttctgc atgctgctta tactcattta agatcgcttc 2372461 gttcaaaatc cggcttgcgt cgtatccgtc gtttgccctg aagaaataaa agtaattgcc 2372521 ggcaaccgta tcctctttga caaccgtcgg cagggaacgg agattaaatg cggccgtctc 2372581 tctgatccgc tcttttgtcc agttttcttt ctcaagcatg cgctggtcaa ttaaacggta 2372641 ggttttcccg agatctagcg cgtaataaat tcttgtctct gcggtatgat cgtcataaat 2372701 gagcgggata tcttcgctgg acttgtccgg gaaggaagtc gagcggatga ccggataaat 2372761 gcgagtttct ttcccggtca tttcctgagc cttcccttcc attgccgtca tcgcttcgga 2372821 gacatagtac acgatctcat caatggcttc gtcttttttc agttcccatt ttgcaataat 2372881 cggcggcaaa tcgagtgtaa tccctttttt agtcgtttga tcctcaacac ggagggtgtc 2372941 tttttctctg tcaaacagaa aggagcgatt ctcgtgctga aggcgctgct tcagtatatc 2373001 tgacagcttc cttgaggtca ttttcaaacc gatgtcctcc tttacgcttt agcgagagag 2373061 tctgttaaaa actgttcaat ttcttctttt gttttgcggt ctttgctcac aaaacgattt 2373121 acttcttttc cttcattaaa caccacaaag cttgggattc cgtaaatttc ccactctgca 2373181 catgtatcaa tgaatttgtc acggtctacg tagtagtagg tgaattcagg gaaattcgct 2373241 tccagttcag gcaggaaagg ctctacaaaa cggcaatccg ggcaccaatc ggccgaaaac 2373301 ataaatacag accaatcatc ctttaccgct ttttccagct cttgagttga ttcaattttt 2373361 ttcatttcat atccctccag ttgtttatgt tcttacatgt tttttatcga tactcgtcca 2373421 tttggatcat accaaactgc ttgaggcaaa accacttata tgcaacgaat gaatatgtaa 2373481 gattggcttt cccattatca ttatcatatt ttatttgcat tatcaagctc gtttcgttta 2373541 acatcgtgta catgagggtg aaatttacag atggatatac ataaggaggg atttttatta 2373601 tggagtttat cgtctattta gcaggagaaa tccacagcaa ttggcgcgag gaaattaaag 2373661 aaaaaacaaa atcactgaag ctcccgatta cgtttgttgg cccgatggag aatcatgacc 2373721 gctcagacaa tattggtgaa gaaattatgg gcgtacagcc aaatgccgtt ttaaaggatg 2373781 acaaagcctc tgacatcaac aacttcagaa ccgccgtcct gatgaataaa gcagactttg 2373841 tgatcgccct gtttggcgaa aagtacaaac agtggaacac ggcaatggat gcatcatatg 2373901 cgatcgcaaa aggaaaaccc ctgattatca tccggccgga atcgctccac catcctttaa 2373961 aagagctttc caataaagcg aatattacgg ttgaaaccgt taaccaagcc attaaggccc 2374021 tttcctatct atttgaaaca gaataagaaa aaagcttgtc gatccgggct tactgctcgt 2374081 tcaacaagct tttatgaaac ctacatattt tctttaatcg catccactgt ctgcttatcg 2374141 caggctgtta caagtttgat gagcatttct ttagcagcag cataatcatc aatatgaatg 2374201 atagtagcgt ttgtatgaat atagcgggaa catattccga taaccgctga cggcacaccg 2374261 ctgttcgaaa tatgaacctt gcctgcgtct gttcccccgc cggatacaaa atattgatat 2374321 ggaatatcat gcgtttcagc catatcaaga acgaattccc tcattccgcg atgcatgact 2374381 gtcgttctgt caagaatgcg cagcaaaaag ccttttccaa gctggccgaa ttcatttttg 2374441 tctccgctca tatcgtttgc cgggctggcg tcaagggcga aaaacaagtc cggtttaatc 2374501 atatgagaag ccgtctgcgc gccccttagc cctacttctt cctgaaccgt tgcacccgca 2374561 tagagtgtat tcggaagctc tttaccgtgt aattccttca gaagttcaat gcttaagccg 2374621 catccatatc tgttatccca tgcttttgat aaaattttct tttcattcgc catcgtcgta 2374681 aacggacaaa caggcacgat ctgctgtccc ggtctaatgc cgattttgat ggcgtcttcc 2374741 ttatcatccg ctccaatgtc gatcatcatg tttttgatat ccatcggtcg gtttcgctgc 2374801 gcatctgtca ataaatgcgg cggtatgctt gaaatcacac ccggaaccgg cccgttatct 2374861 gtttgaattt caacccgctg cgcaagcaaa acttggctcc accagcctcc gagcgtctgg 2374921 aatctgagca gcccgttgtc tgtaatggat gtcaccatga agccgacttc gtccatgtgc 2374981 ccggctacca taattctcgg tgcgtcctct gcgcctcgtc tgactccgaa aacacttccc 2375041 agtctgtcct gaacgatgtc atctgcatat ttggctagct cctgcttcat aaaagcacga 2375101 acctgatgct cattgcccgg cgcgccggga agctgcgtca gtgtttggaa aagcgctttc 2375161 gtttcttgat tcatgttttc ccctcatttc tatgtagtcc ttttatttta ttagaaacaa 2375221 tgaagttttc caagcactct gacccaatct gctcgatcag ccgcgtattg cttaacagga 2375281 tttggctgtt tctgtataat gaaaagtacg atcaaccagg aggtgcttta ttttgaaatt 2375341 gcgtcatctt cttttaggag caggacttgg aatttgtacg gctgtcgttg tgagacaata 2375401 tgtgatgaag ccttatattt cttcagaaaa agcgcttcga attgtaaaat ctgcttttaa 2375461 gcagcggggc ccgattgacg gatcatggat ttacacccag ccggagccct acaatattaa 2375521 cggagaaacg gtacaggtat acaaaaccgg cattacacga tcagctttcg gagaattaga 2375581 acagtatgaa gtcatggtgg atgcgaaaac gggagaaatt gttgatgtca ttgatacaat 2375641 cgcctcttaa caccggacaa gcaaaaaata gaagccgctg cctatgcagc ggctcttttt 2375701 tattatatcg cgcgaatcgg tttgtatacc ggataccaca tcgcatcctg cactgcctgt 2375761 ataatgtctt caggctcttc cgtagcgacg ccttccttca ttgcggtttt tgcaacttca 2375821 acagcaacgg ttgccgaaac agtgcgcaaa tcttcaactt ttggaagcat cggcgcccca 2375881 ggcaccccga cattgaccat acctgcgatt gcccgggcac atgcttcaaa catgccgtcg 2375941 gtaattaatt ttgattttgt aacaatcgtt ccaagaccga gaccagggaa gacaagcgcg 2376001 ttgtttgcct gcccgatatg atacgtaact ccgttatatt caactggcgg gaacgggctt 2376061 cctgtcgtga tcagcgcacg gccttctgtc cattcgatta aatcctccgg ctttgcttca 2376121 gaaagagttg tcggatttga cattggcaaa atcgccggcc gtttcacatg tgacgccatt 2376181 tcttttacaa tttcttcagt gaaagcgccg gaaaccgtag atgtgccgat caggatcgtc 2376241 ggtttcgcct gccgaaccac ttcaagaaga tcaatgcctc cgccgtctcc gttccgctga 2376301 taatccttca cttcatcagc cgaacgggca tacggctttt ggaaatcaag aagctgatcc 2376361 atatcatctg ttaacagccc gttcctgtct atgcaccaga agcgcttgta tgattcttct 2376421 tcactcagtc cctcgcgcac caatgcttcc cgcagctgtt cggcaattcc gattcctgcc 2376481 gttcccgctc cgaatataac aactctgtga tctctcagcg gaactttaga cgcttttgca 2376541 caggataaga ctgcggccaa agaaacagcg ccagttcctt ggatatcatc attgaaggta 2376601 cacactttat ctttatagcg tttcaaaatg cttcgcgcgt ttttcgcccc gaaatcctcc 2376661 caatgcagca atgcattcgg aaatgtttct ctcgccagcg caacgtagtc gtcaataaat 2376721 tggtcataac gttccccgcg cactctggaa tgctggttgc cgacataaag cgggtcgttc 2376781 aagaggctct cctgatttgt ccccgcatct aaaacaacag ccagcactct gctcggatca 2376841 atgcccgcag ccgctgtata aaccgccagc ttgccaatag aaattgcgat tcctccgacg 2376901 ccccagtcac cgattcctaa aattccttcc gcatcagttg caacaattaa atcgatcgta 2376961 tcgctttgat ctttatactg tttaaaagct tctttcatac cgtccgggtc atcgattgac 2377021 agatagagcc ctcgtggttt tctgtattca tggctgtatc tctgaattgc cgttccgact 2377081 gtcggtgtgt agacaatcgg gagcatttcc cctaaatggt catttaacag gcggtaaaac 2377141 agcgtttcat tccgatcgtg cagcgccgtt aaatagacat ttttgctcaa atcgtcaggc 2377201 tgtgcggaat attgttcata cgctcttttc gcctgatcat caattgttaa taccttgggc 2377261 ggcagaaagc cttttaaacc aagttctttt ctttcttcct cagtaaaagc aacacctttg 2377321 ttcaaaaaag gaacagagag cacttcaagg cctcttaatg ttgtttgaat gtctccttcg 2377381 tttgttactc tgaattgttt caccctgcct cttcctttct gagcataata gtactaggtt 2377441 tgcattatta gccggaaaac atgcagggta aacataaaaa tatgctatcg cttcattcgc 2377501 ttaactgact ttttgatgct tccgtcctcc tcccattgaa gggcgcgata ctcggcatca 2377561 tggtaaaaaa taaaccaagc atctttttct gctgcgaacg cctgccattt ctgcttttgc 2377621 gggatagagg tcatcggata atcatcgtaa gccagcaccc atagcggatt gcggtgggca 2377681 tgtgtcggca tcagatctgc catatgtacg gcagtttcac ccgcatcctc gcatatcagg 2377741 acactgtgtc cgtcgctatg gcctccggtg tgatgcattg taataccctc tgtgatcgtt 2377801 aaggtgtctt caaaggtttt gacttggcca gctacagcct cccaattttc tttccaatac 2377861 gtatttttcg acctgatatt cggatggcgc atttcgtccc attcaacagc tgatgtataa 2377921 atcactgcat tcggaaagac agagacgagc cgttcacctt catattccgt taaaccgcat 2377981 gcatgatcaa aatgaaggtg tgtcattgcg atcacatcta tatcggcaac cgttaatccg 2378041 agtgcagcta atgagggttt cacattcgac tcttgtgtca cgccatagtt tcgtttttgt 2378101 ttatcagtca gcttgccgta cccaattccg gcgtcaatga tgatattgag cccatccttt 2378161 tgaatcaaaa tagggtctgt tcttagttca atctggtttt tttcattgac tggatatttt 2378221 ttagaccaaa gcggctttgg cacaacgccg aacatggcgc ctccgtccat atgcgtcacg 2378281 cctccgtcaa gccaggtcaa cgtgatgttt ccaattttca ttgtttccat tttcaccccc 2378341 ccctatcatc atggtagcaa acggcccata aaaaaaacag actcctgtca gagtctgtct 2378401 ttacgttctc cattcaacct cagcccgata gatcggctgg ccgagtgcag agaatttttc 2378461 ttcatattct gtcataatat tgccttccag attgctgtta tgcaaatcga gactgacgta 2378521 tgtcagcagg aggccgtact cagagaagct cttcaaagag tactcaaata aacctcggtt 2378581 gtccgtttta aaatgaatcg atccgccttt gcccattact tcttcatatt ttttgaggaa 2378641 gtgggaatat gtcaggcggc gtttttcatg ccgtttcttc ggccaaggat cagaaaagtt 2378701 caagtagacc cgtttcactt cccccggctc aaacacatcc gtcagcgtgt ccgcatctat 2378761 attcagaagc tttacattct gcgcttcgct gtcttttact ttttggacgg ctgtcacgat 2378821 gacgctttta aataactcaa taccaatata attgatgtcg ggattttgtt tggccatacc 2378881 agaaataaat tggccttttc ctgtaccaac ctcgatatgg atcggattgt cgttgccaaa 2378941 cactgtgttc catttccctt tataatcagc aggattgctg atggcaatat ctgcgttttc 2379001 agccaaaaag tcatcagccc aaggcttgtg gcgcattctc atatgattga cacctctatc 2379061 tattatttcg actaacaaca taccatgaat taaaaagacc cgcaagctcg tttttccagt 2379121 gtatctctct taaggccgag cgcataaaaa aagagggtcc cgtctgctgg aacactcctt 2379181 tcccatgtat aaaaacgctc tgttttgaac aatttaaccc gtatgatact gaagggatgt 2379241 gtaccgttat gggtttacat tatgagcatc aagttcattt attgaaggat atattgactg 2379301 accatcaatt ggactgctgc ggaacagtcg cagagtacga gcagcttgag cgtgtgatta 2379361 aatcactgat ggcaaacacc gagcttgatt caaatttcaa aaacgtgctt gaagatgttt 2379421 accgctacag ccaatcagga atatcgtcca aatccatcga ctcacacata caagagcatc 2379481 agaacagcct gtctcaatgg gtagagcaaa tggattcgta ttcctgatta atcaacaatt 2379541 cgtttcatga ggatatgcag ctcttccatt gcatcatgaa attccttatc attgcctttt 2379601 gctttatgcc aggcaatgaa agtaattgtt tcagataaca cataccaagc cattcgcaac 2379661 cgaaggcttt ctgtcagctc tatgccgtac atgctcagcc agctctccca agctggcttt 2379721 tcgacgtagt ggtacagcaa aggcccgagg tccatcgccg gatcagcgat catggcgccg 2379781 tcccagtcaa ttaaatacag ctggttgtct tcagacaata gccagttatt atgattgaca 2379841 tcacaatggc aaacgacttt ctcaccgaaa tgcacttcat gcaggtgttc ttccaaatac 2379901 ttgatccctt cttgaatcag cggcgaagat tgctgcacag caaatacagc ctgcttcagc 2379961 tgagacaaaa gagcccccgg gttcagcggt tcttttccaa gtctcttcag catgtccagc 2380021 aaggcttttg atgtgtgtat tttacgaagc aattcagcaa cgggccgtcc gctcatgtct 2380081 ttaggcttca gctctctgcc ggtcatccag tgctgggccg taatgacgtc cccattttcc 2380141 atccgttttg tccaaaccag cttcggaaca atgccttcgg cggataaaac agctaaaaaa 2380201 ggtgagctat tacgttttaa aaaaagctgc tgcccgttat gtttcgcata atatgcatct 2380261 cctgtagctc ctccggcggg gaagatctcc caatcgctac ctagtaattg tcccaaccag 2380321 ttcatatcaa tgttcaaccc atcatttctt aaaatatttt agaattaagg ctaatcgttt 2380381 ctagtctatc cagcgaatgc ctttttcgta cgaatcgtat aaaaataaaa aagacagcta 2380441 ttgagagtct catatgctaa tcaatagccg tcctttaaat tttagcgcta tagcacaaac 2380501 ttcgtcaagc aaaactctta agatctgatg ctaaatataa gataaccgtt ccgatgccgt 2380561 ttactgcaac cgttttcttg atttctgttg ggtcttcctg aaatcctgat ggatcacata 2380621 aaagccgata aggtatgtcg tttggcagcc tccactcgac ggagtctgga ctcgcgtgat 2380681 ggataacaat gatatctttc cattcgtcaa cctcgtcaag atcataaagc ctgtatgcga 2380741 taaggtgttc ttttagcgtc aagcattcaa gatggcgctg gatgtctgca gcggacctaa 2380801 gacggaatgc aggatgcgct tttctcagcg agatcagcct gcggatatag tgaacatctt 2380861 ctttgaatgt ttcacggcga tcccagtcga gctggttgat gctgtcactg gattgatagc 2380921 tgttttccac tccctgcttc gtccggaaaa attcctggcc gctgtgaata aacggcaccc 2380981 cttgggcaag caaaataatc gcggctgcaa gcctttgcct gcttcgcttt cggctgtcat 2381041 tttcttgagg aagcgcaaag ctcattttat cccaaaaggt gtgattgtcg tgtgattcga 2381101 cataattgat ggactggctt ggttccggaa caatcggtgc taatgccttc catccggaag 2381161 acccggcaat tccatgcatc acagcttgtg ctgattcacc gttgccgagc gcaaaccctg 2381221 ttgccttaag gtgaaaggtg ttccctttta cagcgtcacg aaacatatca ttaaaaaagc 2381281 cgatgcccgg cattcttggc gcgttcgcca aagcagcttt ctgttcatgc ggcagcggtg 2381341 tagccaggtc ccacccttct ccaaaaagca ggattccggg ctttgcctta gttgctttct 2381401 ctttcatata aagcacggtg tcaatatcta aaatcccgag gagatcaaag cggaagccgt 2381461 caacattgta ttcttcaagc caatagacca cgcaatccgc aatgaatttt cttgccatcc 2381521 ttctttctga tgcaatatca ttgccaacgc cggtgccgtt tgatggcatc ccacattcgt 2381581 cgtgccggaa aaaataaccg ggcactgtct tttcaaaggg ggaattctcc ctcttataca 2381641 catggttaaa aacaacatcc agaatgactc gcagaccgtg ctgatgcagg gtattgatca 2381701 tttgtttcag ctctgttttt ctcgtttgag gatcatgagg atttgaggca tagcttccct 2381761 ccggggcaaa gaaatgaagc gggttatatc cccaattgta tgcatcaagc ggcttctctt 2381821 catcaactcc ggcaaaatca ttcaccggca gaagctccac atgtgtcaca ccaagctctt 2381881 ttacatacgc taatcccgaa gaactgccat ttgcggtttg tgtatcagtt tccgtcagcg 2381941 ctaagtattt tcccttgttt atcatgccgc tgttttcatg gatggagaag tcgcgaagat 2382001 gcgtctcata gatgacggca tccacagggt gtgagaatgg tttaagagga gcagtccatt 2382061 tcatttgatc cgggcgcaag acgacgccct tctctccatt tacagtcaca gccttggcat 2382121 actggtcaac tgtttccatc cattctgaat tgttgcagat gcaaaacaaa tactcatatc 2382181 cgtgaaggtc acctgtgacc gtgacggcat agacgccttt ttccaagcga gtcatttgga 2382241 atgtgcgccc gcttttattg gggtgtgaaa gcttgacagc agctgaggtt gcagcaggcg 2382301 cccatacttt aaatacggta tgatccgcgg tataaacggc gcccagctct ccgtcataat 2382361 aaaattcgtc atcaaacgct gccgtccgga tgaccgcgcc aatttggaga tccgttttgt 2382421 ggccgctgga tgctctgacg caatggattt ttccaaatgt cacaggatgg tcggatacgc 2382481 agacgtactt gtattttgct tcaagggagt attcctccct gacagccaga ggaaaatctg 2382541 ttatttctgt ctcaagccga aacggcggtg tcatgatttc cttttgttca gcaggaatca 2382601 gaacagtaat gatattcatg tcatcgacat acgcttcgaa gctgcggcgg atgctgacca 2382661 tcggaagctc tctcctccaa acacgtttat gttttgattc ttaggggtga aggactagat 2382721 gccagacgaa acggggtagt gcccatgatt tctccgtcag catggaacgg gattttgtcc 2382781 ttcgtgtaaa atgtaatgtc cttcgcttta aacatcgtaa cgccatccat ctttgtatgt 2382841 tttccaaatg ccatgagaca taaaagccaa tattttttca aaaacggctg gttttcaacg 2382901 attacgatat caaatgtctt ctcgcgcgga tttgctaggg gcgccgcctt catgcctccc 2382961 ccgtaaaacg gatggttgga tacaacggca aaccagacat catgaaattc gcgcgtctcg 2383021 tcttccgtcg tacaagctaa tgtaaacggc ttaaaggttg ccgaagcgtg caaatgagaa 2383081 agcggataca caagaaatcg aaggcggaga aaaagaaaaa cccgtctcaa cggaaattcc 2383141 atcgcctttt tattgacata tgcgtcaaac ccgatcccga tatgattcat aaaataaaga 2383201 atctgtgatt tatcctgaag gaaattgacg ctccctaaat gaaaggttct tgttaacggg 2383261 cgctttacct tcttgatttc ctgtatcaga tcgatttttt taatagagaa ccctcgcgaa 2383321 aaatcattat acgcgcccgc cggcacaaag ctcagctcaa tatcgtcaac atctttcagc 2383381 ccgttgacaa cttcatgcat ggttccgtct ccgccaatga cgatcaggcg cttcagctta 2383441 tattcctgta tcgttgaaat ctgtctggcg agcacctcgg cgtgtcccgg atgttcagtt 2383501 aaaaatgaac ggtgctcaac ctttcgtttg atcaattctt tttgaatgga cttccaaaca 2383561 cgcaggccgt ttcgatgtcc tgctgtcgga ttaataataa aaaaccaatg gctcatcttt 2383621 ctcacctgct tatgttatga gaaaaccgct caaatcgttc tcttttactc cagccactcc 2383681 tgtctgcgat aggagtcaga catgcagtaa gacaatagag cctttgcagc ctttacctga 2383741 tgatgtttga tcggagcagt gtttttcttc tgccgctcaa tccattcttc cgcgctccgc 2383801 ttatccgcta tttctaagcc gtatggcggc tccgggtaat cgatgtacga cgttctgctc 2383861 agaagcaatt ttcgaaccgg aatctcagcc tgtttttcct ttacgatctt tgacacaacc 2383921 gagtccgtac gaaacaggct aagccctgga tttaacactg atgcagtctg agaggctgtt 2383981 ttcttgtccc aaaaacgatt tttagaccct atgtagacac tgtcttcctc agcctctaaa 2384041 aaagaaacgc aataaatttc cagaggagaa ataatcacaa tgcttaattc aaccgccgcc 2384101 tgctgaattt tcagcacagg cttatacata ataaaataag aatcaggcag ctgctgggtc 2384161 agataacgca aaatgcggtc ctgcttcact tggtttgaga gttgagatat ttctgaaaga 2384221 gtagagcttg cccatttgag ctgaaaatca tataaatgcc ttttataaaa agaagcaagc 2384281 gccaccctgc tcttcgggag ccttacatga atatcttctt cgtcctcaaa ccattggtgt 2384341 ctctcttctt gtatatcggc ttttatctct tcttttcttc ttttcaatga aaattttttt 2384401 cgtttctgca ccggttccgg ttcttcagca ctggcttgcc tttcttcatg ctggcgctcc 2384461 gctgcttcta ctagtgaaag ccagcgctct tttttcaaac gtacaaactg gttgatataa 2384521 tggtacggat caagctcata tctcgatata taatcatgaa ttttgatgat ttgtgccatg 2384581 tttgtttctc cactccgcaa tgaattaaga taattgaaat ttgaatattt cctcgtattt 2384641 tggtgattgg ttcaagtgta tttgaaagag cgaaaatcgt tcagccatca tcgaaacctc 2384701 gccgctttca aacggaacat gagctggaaa tccatcttcg cctgtccatt ttcttgccag 2384761 cgtcatatga ggatgatacg gtcttttttc cacttgaaag ccggcctgaa gtacagcctg 2384821 cttcgtatgt tcccgcagtc tatcaagcgt tttgtttttc tttggctcca gatgtaaaac 2384881 gcgcggcttt ctgcggtcgc cgaatacatc tatcttgcca aacttaattg aaaatggatc 2384941 aatttctgaa gcaatctctg ctagcgaacc ttcaagcttc tttatttgtg tctcatccgc 2385001 cgctccgaga aaaattaacg tgatatgata gtcaagcggg tgcacccatt tttgaaacgt 2385061 caatatcggt tcgtttttcg cagcctggta gatcggattt gcaattccct caggtatggg 2385121 aacgccgatg aaataatgag gccgtatatc tggcatccgt ctgacactcc cttctttgac 2385181 agctattatt ttatcaataa agaggctgtg cggatagagg aacagtgtat gaaaacactc 2385241 tcgcacaaac gtttattatg ttaggatatt atatgacact tgttttattc agaaaggaat 2385301 gacaatgttg aaaatcgttg caaacacagc tgatctgata ggagatacac cgctagtgag 2385361 attgaatcgg cttcagccgg aaaatgcggc acaagtctat ttaaagcttg aatttttcaa 2385421 tccgagcggc agtgtgaaag acagagccgc ttatcaaatg atcatagaag ctgaacaaaa 2385481 cggtttactc aagccgggat cagttattat agagccgaca agcggaaata ccggcatcgg 2385541 gctcgccatg aatgcggcag cacgcggata taaagcaatc ttagttatgc ctgatacgat 2385601 gacgaaggaa cggatcaacc tacttaaagc ttacggtgca gaggttgtat taactcccgg 2385661 agaggaaaga atgccgggca gcatcaaaaa agcgaaggag cttgccgaac aaattccgaa 2385721 cagctatatt ccaatgcagt tcgataacac tgctaatcct gatgcgcacc gaaaaacaac 2385781 agcgcctgaa atcgcccggg caatagagga aatcggaaaa ccgctcggcg cttttgtagc 2385841 ctcctctgga acgggcggaa ccattaccgg aacaggtgag gcgctcaaag agctttttcc 2385901 ggatatcacg gttcatgttg ttgagccagc gggttcgcct gtattatccg gcggaaaacc 2385961 tggcgcgcat aaacttgtag gaacgagccc aggctttata ccgccgattt taaatgaaga 2386021 cgtttatgat gaaattatca aaatctctga tgaagacgcg tatacgacga caagacggct 2386081 tgctgctgaa gaaggaattc ttgtcggtcc ttcatcaggc gctgcctgct tcgcggcaat 2386141 cgaaacagcg aaacgcctct ctcctgacaa agttgtggtc tgcatgacag ctgatacagg 2386201 agaacggtac ttatcaactg atttatggtc atttatttaa aaaaaggact ggcttcagca 2386261 gaagccggtc cttttatttt gcaagctcgt aaatggcctg agcatataac gctgtcgatc 2386321 tcagcaggtc atcaatttcg atatattcat ccttttggtg tgcgctgtca gggcgtccgg 2386381 ggaacagcgg gccgaacgcg acaccggctt ttaaggatct cgcataagtc cccccgccga 2386441 ttgagattaa atcagctttt ttacccagct ggccttcata aaccttttgc agggttttga 2386501 ctaacggatg atctgcggac acgtgatgcg gcttgctgtc tttgaattct cccagctcaa 2386561 attcagatgc gctttcgaat gtatcgcgga tcactttgct ttctgctgtc acaggatagc 2386621 ggatattgat cccgagctcg cctccttgcc cttctttata gcgcagtgtt ccgacattta 2386681 atgtcagctc tccgctgatt tcatcctcac agtcgatgtc cagttttttt cctcttgtat 2386741 cacctgagaa cttatctgtc acaacttgca caaaccgctt tcctgcatcg tcaagctcag 2386801 tctgctggag aaattcgcac aataaaatgc cggcattgat cccattgttc ggttccatcg 2386861 catggcagga aagaccgtac atacgcaaaa tgagctgtcc gttctctatt gcagcttccc 2386921 ctttttggtc cgtcgtgcgg agcatgtctt taaatgaaga cagaatctct tcatttttcg 2386981 gcccttcaat gacagcttcc gcagcgtcgg gcaccatgtt taagcgaagg cctgattgaa 2387041 acgagacaag cactgccttt ggttcagctt gatttgggcg gtgcggaata agtaaagaag 2387101 catcgatgat ccctttttcc gcattaatga tcggaaaatc ggcgtcaggc gcaaagccca 2387161 ttgttggcat ttcttcatgc ttgaaataat gctctacgca tctccaatca ctttcttcat 2387221 ctgttccgat aatcattctg actcgcttgg acaggggcaa attcatgtct ttcacgattt 2387281 tcagcgcgta gaatgccgcc attgtcgggc ctttgtcatc aatggcgccc cttgcataaa 2387341 tccgtccgtt gcggatttca gctgaaaatg gatcactcgt ccacccatct cccggcggca 2387401 cgacgtcaac atggcaaagt acgccgataa tgtcatcgcc ctccccccat tcaatatgac 2387461 ctgcgaagcc gtcaagattt tttgttgtaa agccttcttt ttctccaagc tccagcaatg 2387521 aagtcaggct ggcatttacc ccttctccaa acggtttacc gggtccggcg gttgtttcgt 2387581 ccatgacact gttgattctc aaaaattcct gtgtatcacg aattaaatcc tctttttttc 2387641 tgatcacttc aacttcccag ttcataatga tcccctttcc gcaagaaatg acttgcaaaa 2387701 accaaataaa acgaataata ttaatggtgt tttgttaaaa cgttcgtaat tggaggatac 2387761 tatgtttcat ctaaaagagc agcaaacatc cataaagcaa gaaatcatag cagggctgac 2387821 gacctttttc acaatggtct atatcgtcgt ggtcaatccg gtcattctgg ctaacgccgg 2387881 ggttcctttc gaccaggttt tcaccgcaac gattattgcc tccattgtcg gaacgctgtg 2387941 gatggccctg gcagcaaatt atccgattgc tattgcgccc ggcatgggct tgaacgctta 2388001 tttagccttt catgtcgtaa gcgcaagcga tggcggcatc acgtacgcaa cagctttcag 2388061 cgcagtattt acagcagggg ttctcttcat tattctatcg ttaacgcctt taagaaaaca 2388121 acttatagaa gcgattccaa acaatttaaa atacgggatc acaacaggga tcgggctgtt 2388181 tattgctttt atcggtttgc gtcaagcggg aattgtggca gctgatgagt caaacctggt 2388241 cactctcggc aatctgcatt cacctggtgt tatcttaacg ctggtcggcc ttttgatcag 2388301 cgtggtcctg atggtgctga atgtaagcgg cgctttattt atcggaatgg cagctaccgc 2388361 tttgatcgcc tttttcaccg gtcagctcca tttttcaaag ggatttatgt cgcttcctca 2388421 tttgccggaa ggattgatga tctcaaatcc atttaccgct tttggcgatg tcattcatca 2388481 cggcctgtac gctgtcgtct tttcttttct attagtcacc atttttgata cgacaggcac 2388541 gatgatcgga gttgccgagc aagccgggct gatgaaaaac aacaagctgc cgaacgtgcg 2388601 aaaagcgctg cttgctgatt caaccgcgac gacagtagga gctgttttcg gcacaagtcc 2388661 gacgactgca tttatcgagt cttccgccgg tgtcgcagcc gggggaagaa cggggcttac 2388721 ggctttgact gtcgcggtga tgtttgcggc ttcaatgttt ttcagtccgc ttgtcagcgc 2388781 cttgtcaggt atagccgcca tcacctcgcc tgctttgatt atcgtcggca gcctgatgat 2388841 gggctcagtt tccaatatga actggaaaga gatggacgag gcatttcctg cgtttctcgt 2388901 cattctagcc atgcctttga cctcgagcat ttctacagga atcgcgcttg gctttatttc 2388961 gtacccaatt gtaaaagcgg cgcggggaaa atggagagag attcatccgc tcgtcatcgt 2389021 tttcgccatt ctgtttttca tccagctgtt tattttataa ggatagacca aaaaacccaa 2389081 acgtcgccgt ttgggttttt tatgtaaaca ataaagagac agcggccgct aaaaaacaac 2389141 aggcggcaaa cgcatagtgc aggatgttga tacagctttt tctggcccga taatattcat 2389201 cactttcctt atcggtgcca attaaaaaag gggcatccat gaccttgtca aaaataagcg 2389261 tcaggatata acggcaaacc cctgtgtata ccagcagcgc aatcaccttc agccaaattg 2389321 gggaaacaaa tatgagaaca gtgaaagctg acagtagcat gtacatctgc cttgcatact 2389381 cgccattcct cagcataact ttaaaaaaca actccttata gcctgtgcag atcgttcgtc 2389441 ttttaaatat cctttttgaa tttcggtata ataatggttt tcttctcatc ctgtctttta 2389501 cttttggcat tcccgcctcc tgactcatca tcatcacaag tcctgcaagg gcaagcctgc 2389561 tttttttctc ttcagtcacc tcagcttcaa aagccgtgaa cgaggctgtc tttttcaaac 2389621 tgcggataac tgagaaaaac aaaaataaaa tgccaaaaag cgcaagcaag tgccgctcag 2389681 taaaaacaat caggatagca gaaccagcaa aaagaatagc tctgacaagg gtatcgccaa 2389741 tccatctcga aatggagcgc ggctttctga tcctgtcttg ctttaaggat aaaaagaata 2389801 tatgaaggcc aaacaaataa cacaatagag cagtgctttc tgcgaatgtg atgagaacag 2389861 aatgactgat caagggaagg acaatgaaaa agagaagcag ccatttagcc agcgtggcca 2389921 gaaaagaata caaaagcgca taccgtttga gctgatagat gatttccttc ttttgcagca 2389981 aaaacacttt gtccgcttcc attaaaaatg tacgaatcga acctgtaaac atgatcagca 2390041 cacacacagc atacagccat ctccattccg ccacttcaga ccactcataa agaaggcctc 2390101 ttccgttcat caaatcaata tactgataga tgacaaaagc aatcgccggc aaaacgatat 2390161 agagagcgac tgtccagtca atgaccgcat gcaacacttt aaactgatac ttataatagt 2390221 caaacagcct tcgaaaaaag agcgtacgcc cgttcatagc cgatcacctt gaactgcctt 2390281 ataaaaacag tcaagcaatg actgcccctc taatccggtc ttgtcctgaa catcttttaa 2390341 cgtgccttgg agaaataatg aacctttctc aatcatataa aaccggtcac agattttttc 2390401 cgcggtatcg agtacatgcg tgcacataag aattccggct ccacgttctt tttcagcctt 2390461 aagcatgtcc acaaagcgtt tcgtcgatat cggatcaagg ccgataaacg gttcatcaat 2390521 cacatacata tccggcttag agagaaaggc ctggataagc attagttttt gctgcatgcc 2390581 cttcgaaaag gtgacaggca gctcatgttt gacatgatct agcgaaaacg tctgcagcag 2390641 gctttgggcc cgatgcgcaa attcactctc ttcaatgccg tgaagtgtgc tgatcagatc 2390701 caaatgctcc cacagcgtca gttcttcgta gaaggacgga tgctccggaa tatatgcaaa 2390761 tgaacagtcg ttccaggcaa tatgcccttt aaaatcttct gaaaggccga gtatcgcctt 2390821 gattgcggtg ctttttcctg cgccgttagc tccgatcagt ccaaccagtt ccccttttct 2390881 gacttccaga aaaacatcgg tgagcacttt ttttcggctt gtatacccgg cctgttctat 2390941 tgaagcttca agcaaatttg tcaaaactca ctcacctcca aaatttacta cgaaatagaa 2391001 taaaaaaagt ttctttaacc ataataatat tgagccgaaa tacatagtaa tccaacaagg 2391061 atggctgccc aacgcgaaat tggaaaaaat taataggagt tatccctaga ttcatcactg 2391121 caatatcgtg tataatgagg gcgaattatt ttaacaatta cagatgtctg cctttgttgc 2391181 tatttcgtac gcagttgata gtcgtgagtt gtggttagtc aagtccatcc gatcttatga 2391241 tagggagtgg ttttttgaaa ccttcaacaa accgtatgct aactcgaatc aaatcagttt 2391301 acatgtttat tcaagaaaaa ggtcttgtga caacacagga actggttgac gaattcggca 2391361 ttacacctag aacgattcaa agagacttaa atgtgttggc atataatgat cttgttcata 2391421 gtccaagccg tggcaagtgg gagacaacga gaaagaaagt aaagattacc tcataaattg 2391481 aaaattacat agggccgcct gagagcggtc cgatagataa cagggcgaag aaactactga 2391541 gccttgtttt tgtgtgctta taaataaaac cccgcattcg gtatgcgggg tttttgtcat 2391601 gcttgcggct catttagcaa atgaagctct tcctctgtca gctcacggta ttctccgggt 2391661 gccagagcgg gatctaggga aacgcgtccc atcgaaagcc gcttcagata aaccacttca 2391721 ttgccgactg cctttgccat ttgcttgacc tgatggtatt ttccttctgt aattgtcaga 2391781 tatataacgg tattgccact gtcgtttgtt ttgatttccg cttttgccgg ctttgtttta 2391841 tagccgccct ctatgtagac acccgtttcc aaatcggaaa tgtcttcccg agaaatctgt 2391901 gattttaaat ggacttcata cgtttttgga acatgctttt taggagaaag gagccgatgt 2391961 gcgagctggc cgtcatttgt gagcagcaaa aagccctctg tatctttatc aagcctgccg 2392021 gctggaaatg gctcaaatct catctcctcc ggcgtcagca gatcgaccac tgtttgctgc 2392081 cggctgtcct cagtcgccga cagcacgccc tgcggtttat tcatcataag ataaatgaac 2392141 tctcgataat caaccggttc cccgtatacg gtcacctcct gcgtatcagg atcaacgtgc 2392201 tcctttacat ctttggcagg tttgccgtcg atcatcacgg ctccagcctt cacaacggct 2392261 ttgacttctt ttctggaacc atacccgctg ttggcaagca gcttatcaag tctcattccc 2392321 aatctctcct ttataaaaga aagcccgcag catgcgagcc ctcagtttca tcatatctag 2392381 ttcatcagcc tgcatgtctg cctttcctaa agaaacctgg caaacggcgg cctaaaattt 2392441 tctgcaaaaa tcctaatcgg tagccgcaat acaggtagac agctccgcca acagcggccg 2392501 cgatcaccac aacaatcgca gcttgcatct ggccatcctg ataggaaata aagaagccta 2392561 atacccactg cacgattttc acggcaatac ccataatggc tgataagacc agcatcaaaa 2392621 cagttcgttt aacaagtatc ttatacgaat agcctgcatg gcgcttaatc atgataaacc 2392681 catataaaag ggaagcgata tatccaagcg ccgtcgctaa aatcgctccg tcagcctgca 2392741 tcagcttgat cagcggaaca ttcagcacaa gcttgatcac gacaccgatc acaaggctga 2392801 caaccgcaaa tttttgctta ttgatgccct gcagaatagc tgcgttgact gtaaacaaag 2392861 agaacagaat tgcgacaggc gaataccaaa gcaaaatgtt tgcccccagt tcaggatgaa 2392921 ggctctctga cccgtaaaag aacgtatacg tcggtcctga caatagagag atcccgacaa 2392981 cagccggaat aattaaaaac aggatcgtct gcatcgtttg attaatctgc tgatttaaca 2393041 gcttatagtt tccgcttgta aacgattcag taatcgttgg aattaatgtc agtccaaaag 2393101 cagttgctag ggaaaccggg atcatcacga gcttctgaac atacagggtt agaatcgcaa 2393161 gcatgtcctg gctgatggct tgatgaccgg cttcaatcat cgctttgtta aacgtatttg 2393221 tatcaatata gttatacaaa gggatggcta gtccgacaaa aacgtacgga gcagcatagc 2393281 tgaacagctc gaaaaacatt ttcttgtagc ttaggtttgc tgtcggaccc gtattcggca 2393341 tcatcgccag caggctgccc ttccgtttgt tccaataaat ataaagcacg accagccctc 2393401 cgaaggcacc gatcagcgct gcgaaggttg catagcccac agcgatgaca aggccgccgt 2393461 tgaaaacctt caaaatcaag aatgtcgcac tcaatagaaa gatgatgcgg acaatctgtt 2393521 caacgacttg ggaaacagct gtcggaccca tcatttggtg cccttgaaag aatccgcgga 2393581 caaggctcat aatcggtacg accaaaagcg ctaagctgac catgcggatg acataaacga 2393641 catgatcaat tgtcaggccg ttattatcct tgcctcccag cgatatttcc gcaaacatcg 2393701 gagccgatag atacagaatg aaaaaggcta tcattcctgt gactagcata accgacatgc 2393761 ccgccttgag cattttcctg cttgtctcat aatccccttt tgaattatat ttggaaacaa 2393821 atttagaaac agcggccgga aagcccatcg tagcaatatt caaaaataaa gtgtattggt 2393881 tgtatccgta ttgaaataat gcaccgcctg tcgccccgac cataatgctg aagggaatta 2393941 aatagaccat ccccagaatc cgcgatatat atgtaccgag cgttaataca aacgtgcctc 2394001 ttaacagttt gcttgacatg tttcttcatc accattttct acgaagattc aacttttcta 2394061 ttttaccaca actgggcatt tagacggtaa taaatacaaa agcaatcctg tgaacattca 2394121 tgtccgcggc aaaagacgtt taaggagcgg ctttctttcg ctataatagt actgcggacg 2394181 ggtgtccgca cacgaaatga aaagaaagtt gatgataaag atgaaacaat atgacgtaat 2394241 cgtaatcggc ggaggccctt caggcttgat ggctgcgatt gcagcaggag aacagggcgc 2394301 tggcgtgttg ctgatagata aaggaaataa attaggacgg aaactcgcga tttccggggg 2394361 cggccgctgc aatgtgacga accgccttcc tgtggaagaa attatcaagc acatccccgg 2394421 caacgggcgt tttttataca gcgcgttttc tgaatttaat aatgaggaca ttatcaagtt 2394481 ttttgaaaac ctcggcattc aattgaagga agaggatcac ggccggatgt ttcctgtgac 2394541 cgacaaagcc caaagtgtcg ttgacgcgct gttaaacagg ctaaagcagc tccgcgtaac 2394601 aatcagaacg aacgagaaaa ttaaatctgt tttatatgaa gatggacagg cagcagggat 2394661 tgtgacgaat aatggcgaaa tgatccatag ccaggcagtc attattgctg tcggcggtaa 2394721 aagcgtgcct cataccggaa gcacgggaga cggctatgaa tgggctgaag ccgcgggcca 2394781 taccataaca gagctgtttc cgacagaggt tcccgtcact tctggcgaac cgttcattaa 2394841 gcaaaaaaca cttcagggct tatcactaag agatgtagcc gtcagtgtgt taaataaaaa 2394901 aggcaaaccg attatcacac ataaaatgga catgctgttt acccatttcg gcctctcagg 2394961 acctgccatt ctcagatgca gccaatttgt cgtaaaagag ctgaaaaaac agcctcaagt 2395021 gccgatcaga atcgacttgt atccggatat caatgaagaa acgcttttcc aaaagatgta 2395081 taaagaactg aaggaagcac cgaaaaaaac cattaaaaac gtgctgaagc cttggatgca 2395141 ggagcgctat ctcctattcc tgctcgaaaa aaacggcatc tctccgaacg tatcgttttc 2395201 tgagctgccg aaggatcctt tcagacaatt tgtaagggac tgcaagcagt ttactgtcct 2395261 cgcaaatggc acactgtcgc ttgataaggc atttgtcacg ggaggcgggg tatctgtaaa 2395321 agaaattgac ccgaaaaaga tggcttctaa aaaaatggag gggctttatt tttgcggtga 2395381 aattctggat atccacggct acacaggcgg atacaatatt acctccgccc ttgtcacagg 2395441 caggcttgca gggctaaatg ccgggcaata cgcccgttct taatcattac tctttaaatc 2395501 tcttgccgcc aaactcacat ttgaacattc cccgcattca tgttagggtg agacttgttt 2395561 tgtttcacct gattgcgggg taattttaag agaggaatga gctgccatcg tacgaccata 2395621 ctaagcctgc gagcaagata taggcgtaca caaaaaatta gagggtgaga aatgttgaaa 2395681 catatatcta gtgtattttg gattgtgatt gcaatcacag ctgcagctgt attatggggt 2395741 gttatttctc ctgacagcct gcaaaatgtg tctcaatcgg cacaagcatt tattaccgat 2395801 tcatttggtt ggtattatct tttagttgtc tctttgtttg tcgggttttg tctctttttg 2395861 attttcagcc cgatcggaaa aatcaaactc ggaaagcctg atgaaaaacc ggaattcggg 2395921 ttattatcat ggtttgccat gctgttcagc gcaggcatgg gaatcggctt agtattctac 2395981 ggtgcggctg aaccgatcag ccattacgca attagctctc catcaggtga aacagaaacc 2396041 ccccaagcct tcagagatgc actccgctat acgtttttcc actggggttt gcacgcttgg 2396101 gccatttatg ccattgtggc attatgcatt gcctatttcc aattccgcaa aggcgcaccc 2396161 gggttaatca gcagcacact gtcaccgatt ctcggggata aagtaaacgg accgatcgga 2396221 aaggccattg actgtattgc agttttcgcc actgttgtcg gggtgtcaac aagtcttggt 2396281 cttggcgcaa cccaaattaa cggcggtttg aattacctgt tcggcattcc gaatgcgttt 2396341 atcgtccaat tggttttaat cattattgtg acagtgctct ttttactttc tgcgtggagc 2396401 ggactcggaa aaggaattaa gtatttaagc aacacaaaca tggtattggc cggattgtta 2396461 atgttgttta tgctcgttgt cgggcctaca gtgctgataa tgaactcatt tacagattct 2396521 atcggacaat acattcaaaa tatcgttcaa atgagcttca gactgacacc gaacgatcct 2396581 gaaaaacgcg aatggattaa cagctggacg attttctatt gggcatggtg gatttcctgg 2396641 tctccatttg tcggcatttt catcgcccgt gtatccagag gccggacgat ccgcgaattt 2396701 ttaatcggcg tcttggtgac accttgtatt ttgacatttc tatggttctc cattttcggc 2396761 gtatcagcca tggatctcca gcaaaaaggc gcgttcaatg tagcaaagct gtccactgaa 2396821 acgatgctgt tcggaacact tgatcactat ccgctgacaa tggtgacatc gatccttgca 2396881 ttgattctga tcgcagtatt ctttatcacg tcagctgatt cagctacatt cgtgctgggc 2396941 atgcagacgt cgtacggttc tttaaatccg gcgaattctg tgaaactcag ctggggtatc 2397001 attcagtccg ccatggcggc tgtgctccta tattccggag ggcttgccgc tttgcagaac 2397061 acagcgattc tggcagcgct gccgttttct atcgttatcc tgctgatgat tgcctctctc 2397121 tatcaatcgc tctcaaaaga aagaagagag atcaaaaaag cggagaaact cgataaacca 2397181 agaagtccaa gagtgaaaaa agcatattaa caaaaaagat ctttccgcgc ctgcggaaag 2397241 atctttttat ttgcgatata aaataagggc ggaaaaacag taaagctgct cgccgtctgg 2397301 gtcgcacgcc gccgaaaccg tatatttgat atctatcagc tgctcctccg atatcccttt 2397361 taaaaatgaa ttgatttccg tttgtaagtc tttttcatgc tcttcatcaa ataccgctac 2397421 cttcagcatt ttatccgctc tcctttctct atcaatctat tccgtttgga acagcgttat 2397481 gatagagaaa tgatgattat ctcgtttccg gataaaaagc tttccgtata tgggatttcc 2397541 tctgtggctc gccgccgtgc tgctccactt tcagcagcac ggcataaaca atgcgcatat 2397601 ggcagtagct gataaggctg acgctgaaaa aagggacaat gcccggcagg tacgcaagca 2397661 agaaaaagag agcaacagtc agcgcaagca tagtaagcgt atattgcaaa tacgccacac 2397721 tgagcaagag cgaaaatttc acatacagac gttttttcca gtcaaaatgg acaagcagcg 2397781 gaaacacata aaaaagcatg gatacgaaca aaaagccaaa tatcataatg gcgaagcgca 2397841 ggatgtgcag aaggaaatga cttggataaa ttaaggccaa atcaatataa atgatcactc 2397901 cgatgagcgc cagtacagcg ccgagcagat ttgaacgaaa aaattcaccc ttgtattcct 2397961 gccaaaacgt tttgagcacc ggaacgttgt cctgcccctg gatccacttc cgcatgacag 2398021 cgaataaagc cgcggtcgcg ggcatgatgc caaacacgcc gagaccgagc aacgtaaaaa 2398081 acagccacag caagtttgta tacgcaaatc tcataatcca ttcgcaaaaa cgcagcatcc 2398141 gtcccagtga gccatcatgt tccatggcgc cccctccttt tttgcattat acattctgca 2398201 tctgaaaaag ctctttcatg ccgatcggct tcttttcggc aaccgagcgc cacattccct 2398261 caccaaccgc gatggagtag gctccagctt cagccccggc taaaatatca tagcggcgca 2398321 gcgggtcttt ccctaaaaaa agatcctcaa gcaaaagcgg atcacctccg ccatgccccc 2398381 cttcattttt gaccacttgt atcgtctgct ttgattcaaa aagcggatag tattcgattg 2398441 tctgctcagg aaaagcaaac ggaattctgg aaggttcgtg aaattcattt gattcaatac 2398501 gtccttttgt gccgttgatc gtcagccggt agccttcata cggggccgaa aaaataatcg 2398561 agtagcttaa cagtgcgccg ccatcatatt tgactgccgc cacgtacgta tcctcgatgt 2398621 caatttcctc gtcaaaaata cacgcgtcag gcctgtatgc agtatataag ctggactggt 2398681 ctcctgcttc aagatgatca tcctttatag aagctttaga ggaacgggga tgccaccttg 2398741 aatagtagtg gcatttttct ttaacacggc acgtcccgca aaaacgcccg tcttcttccg 2398801 gcaaggggtt ccactcactg tccggcccat agtaattcaa ggcgccataa gcaaatacct 2398861 cttccggatt ttgcccgagc caccaattga cgagatcgaa gtgatgtgtt gatttatgga 2398921 cagaaagacc gccggaaaac tgtctcgacc tgttccagcg tttaaaatag ctggcgccat 2398981 gatacgtatc aatataccaa tttaaatcaa cagaagtgac cctgcctatt tttccgtcca 2399041 gaatcatttc ttttattttc cgatgaaacg ggctgtagcg atagttaaac gcgacggtga 2399101 cttttccttc gcttttggcc tccgcttcaa gcacccgatt cgcatcctgc actgttgtca 2399161 ccattggttt ttcagtaatc acatctgtat tccactgaag gctttttaca atatatgcga 2399221 catgcgtatc gtccctgcct gccacaatga cgatatcagg ctttgagacg cgcatcatct 2399281 cgtcaaaagc atcttcgcta aactcaggca cgtgggccag ctcgggaaat ttcttcttgc 2399341 aaacggcaaa acgtttcgga tcggcatcca gcaatcccgt aatctcataa tgagttgaaa 2399401 accgctccat cagtggtttg ataaacatac tgaatgctct gctgctcaat ccgcaaaaga 2399461 cgatgttctt caatatcctc acctctatcg ggcttcagtt agttgagaaa tcagctgcag 2399521 cgcttcctct gttttttcag catacacagg gataaacgcc gccatatcgc gattcaattg 2399581 aaaagaatag ccgttcagct gttttttccc tttttcgatc tgaacggcat agatcgtttt 2399641 ttctcctgtt tttttattaa cagttgtata aggagatgtt ttttcaggag gcaatccgtt 2399701 taacggctga aaattttccg gatcatcgta agcttgaaac atgtcttcag gcacgatgaa 2399761 aacatctccc tcatgggcgg taatttcagt cagcagtttt tcctgaaaag ctggaaagat 2399821 atcgaccttc ccggcattct gctcggcggc cttttttatt ttttcctgta cgccagcctg 2399881 catatcagaa aagagaatga catgcattcc gtccggcctg cttgagcatg atgccaaaaa 2399941 gagcactgag acgatcacac acaaagccgt acgtatcctt tttgtcattt ccccgctgac 2400001 ctaaaaagag gctccagctc tgtcatagct aaaataaacg cgccggctcc gtgcagatcg 2400061 tttgtgcttc tttcgcggct gacataatag tcatagaaac cggctgacgt tccgacacat 2400121 atgtctttga cgagaaacgc tccgtcttct gatgtttcgg ttttatgctg aatcaagcct 2400181 tgatacgctt ttagcagtgt tgtttcgtaa gctctgtcta gatagccttt attgattcct 2400241 tttgcgattg cgtacatgta cagacaggat cctgagcttt ccagccagtt atcagacctg 2400301 tctcccttat caacgatctg gtaccataac cccgtctctt tgtcttgata gcgacagatg 2400361 cttttaatca tgtcctgcag cgtgtttttc cacacatgac ggttcggatg cttcttcggc 2400421 agctcttcaa tcatgtcagc aagagacatg acgtaccagc cgatggaacg tgcccaaaat 2400481 tccggtgaac agcctgtctc ttcattggcc caaggcattt ttttcgcttc atcccaggcg 2400541 tgataaaaaa gtccggtttt tgcatccttc gtatgctttc tcatcaatga ctcctgaagc 2400601 acaacctgat caaacagctc cgtctcctgc ttcagattgg catatttcag tgcaaacggc 2400661 ccccccatgt ataagccgtc aagccacatt tggtaaggat aaccgtcttt gtgccaaaaa 2400721 ccgccctcag acgtccggtt cagtgttcca tataagctgc gcagcctttt tgccgctttg 2400781 acataccgtt catccttcgt ctgctcgtat aatggaaaaa gaatgagacc tgcttgaatg 2400841 gcgtccagtt catctcttct aaataataga ttgccattat catcgattaa gagatctgca 2400901 taagccttcg catactcaaa ataccgcttt tccccggttg cttcccacag ccgcaataca 2400961 ccgcataaga aaacaccctg atggtagtgc cagcggtttg caggtggcag ctcctcgact 2401021 gtgtacgtgt tcataatggt gtttgccaat gcctccgcgt acgtaagagg cgattttaca 2401081 gcgattgatt gatccattga tcccatccct ttcctaataa attccttcct cgccaaattt 2401141 cttcgccaaa cgattcgcta gcatgaccaa aatcagcccg accgccgctt taaatacgcc 2401201 gactgctgta ctgtagctga attggccctg tttcagccct gcagtataaa catacgtatc 2401261 aaaaatttcc gccacttccc tgttagtcgc atttaacagc aaatacacat gctcgaagcc 2401321 aagctccagc gtgtctccga ttttcaaaat cagcaaaacg acgataacgc ttttaatggc 2401381 gggcagcgta atatgccaca tttgccgcag ccgtcccgct ccgtccattt tcgccgcttc 2401441 atacagctgg gggtcaaccg ctgtaatggc cgccagataa atgatcgtcg accagcccgc 2401501 ttccctccag ataacctgca gaatatacag gggccggaac cattcttcgt tcagcagaaa 2401561 attgattttt tcaccgccaa aaaacacaat cagttcatta atcaagcctc cgtctaccgt 2401621 taaaagcaca aacgaaagcg atacaacaat gacccaagac ataaaatgcg ggatataaat 2401681 cagcgtctga acaaattttt taaagagagc aatccgcact tcgttcaata gaagcgccag 2401741 cagtatcggc accgggaaaa atatggccag gttcaaagca aataacacga gcgtgttttt 2401801 taacaagaga aaaaatgtag gctcagtaaa cagcctgata aaatgcttca gccccaccca 2401861 ctcactgccc aaaatgccga ggaacggctg ataatcctga aacgcaatca caattcccca 2401921 catcgggaca tacttaaaaa gcaaaaaata aatacacccc ggcaaaatca tcaagtacaa 2401981 atatttttgt tgaatcagct tgattagtaa gcgctttctt ttttcttttt taaaaatgac 2402041 tgcatcaaca gccggcgctt gcgcttctgc tgttttcatt ttttcctagc ctcctttcac 2402101 ggattcttgc attcactgta gcgcagcagg caaaagtccg tctacaatca tatgatcaca 2402161 tcctgtttta tccctttata atcaagggtt cagccggtcc acctgaaaaa aagacaccga 2402221 tattagaaaa tgattattga caatatctat caatctttgg attaattgta ttaaggtgaa 2402281 gtggatgtta tgaaatgggg ggttttatga aaagaagcca atacaagttt tactacaaac 2402341 tgatcacgtt tttctgcctg ctcagcacca ttccggttat tttggtcgga ttattttcgt 2402401 acgagcactc tcagaaaacg gctatttcca acgtttcgga ggaaaaattc gacacactcc 2402461 agcagaccca gcaaagcatc gagcatatat tgaaaaccgt cgatcactct ttaacccact 2402521 atgtgagttc gccgcctctc cttcgcacat tgtccgagcc tttgcactca gaccaatttc 2402581 aaatctataa ccaagtgaac caagagctca attatctgca aagctttgat accgatctgt 2402641 ccaacatgac gttagtcagt tatacgaaaa aatggtacat gaacaattcc ggtttgtacc 2402701 gtttgaatac agacactctt catgaagcag cctcagcgta cacgaaacaa aaagcgagcc 2402761 gctcctattg gacgcttgag gaaaacaatc atttgatttc aaccaaagaa ggcacagcag 2402821 aaaactgccg ctacaatatc aatttaatta agcagcttcc tttgaacagc acaaatacaa 2402881 agggattggc cgccgcaagc atcccgagct gttcgcttgt caaaaatatg cccggctatt 2402941 caaacgccaa caacctgttt atcatcgatg aaaaaggcct catcatcctt cataacaata 2403001 tgtctgacgt tggtgaatct cttcataacg acggctttgt ccaaaaagtg ctggcgcaaa 2403061 cggccaatag cggacagttt gaaacagtga ttgaccggat tcattataaa gtcacctatc 2403121 aaaaatctga ctataatgca tggacttatt tttctctcgt ttccctgcct gagttaaaaa 2403181 aagaagccaa atcaatcggc tggatcactt ttgcagtatg cctcattttg ttaacgcttt 2403241 cattgctgtt ctcttggctt ggctcccgcc atttttacaa gccgatcagg gtgctttacg 2403301 aatcattcgc aagacatgga gccatacaag agaaacaaca gcctcctcaa aatgaatttg 2403361 agttaattga acagagcttt aagcagctga aggacagaaa tgacgacctt gaagaaacga 2403421 tgaagcagca ggccactcat ctgcagcaat attttatggt caggcttatg cttggaaaac 2403481 tgacggatga ggaggttgat aaccgttttg aaagcctcgg cttaaagcaa aattggcggc 2403541 accttgccct gcttgtgctc caaattgaca cactgaatca tacgccttat gagaaaaaag 2403601 atatggatct gcttttgttt gccgtcaaca gcctgattga gcgcaacatc ccgacggaca 2403661 aacatcttgc ccccgccgta gttgacaaac agcaggcgac gattttgatc aatcaaagcg 2403721 ggacaaagga agaattcatg gctgagctga atgagactgc aaggatgatt caggaaaaag 2403781 cggaagctga gctgcagctg tctgtcagca tcggcatcag ccagccgttt gatgtgctga 2403841 caaaagcgaa aacagcctat gcggaaggct cagaagcgtt gaaatatcgg ctgaaagcgg 2403901 aaaacaagtc gatcatcttt tacgaagacc ttgaccagaa aaaaaccttc aaaacccatt 2403961 ttccaaagca gcttcagcat gagctgttcg atgctgtcaa agcaggagac aaggagaaag 2404021 cggataaatg cctgcacgcg attttacaag ccattttcac ccagaacacc aacccgtatc 2404081 aatttcaaat cgccatcgcc cgttttttga accatgtgat tgagctgatg catgtgcttg 2404141 ggatcgaatt gtttgagctt gaagaaaaca aaatgctgta tgaccaaatt tttgagctga 2404201 aaacgttcga ggataccgaa aactggctaa agaatgagtt tattgatccg atgacagaca 2404261 aagtgaacgc ccgcgcggat gcccagtaca aaaatatttc cgacaacatc attcatatca 2404321 tccatcatga gtttgaatcc gaattgacac tggacgaaat cgcacgcagg ctgcattaca 2404381 acccaaatta tttaagcagt attttcaaaa aagaaatggg aatttcattc agcgagtatg 2404441 tctcaagcta ccgacaccat atggcgaaaa gctggcttgc cgaaaccgac atggcggtca 2404501 aggacattgc cgaaaagctg aaatataaaa actcccaaaa cttcatcaga tcatttaaga 2404561 agctggaagg gattacaccg ggaaactacc gccagcaaaa aagaagcatg taaaaaaccc 2404621 aaaaccgctt gcgcgttttg ggtttttcca atgttatttt gcttgtttaa acgcttcttc 2404681 gtattcctga ataatttgtt ttcctccgct tgactcccat ttttccactt ctttatcgaa 2404741 ctggctttct gtgatgtctc caatcatata tttgtaggtc gcgtcatcaa tgattttctt 2404801 cagttcgtca ccccgttccg actccgatgc ggaatacagg ctttcagccg ggtttgagac 2404861 gataatcttt tcattgtcct cggtcagctc ctcgtacgcc gtccgaagcg gatctccagt 2404921 gttttttaag taggctttat caatggcaat taaagcggac agcggctgaa tatcagtctg 2404981 ccagtctttt acctggcttt ctttgcgtgt aaacgttttg tcctcacctt tgttgtaatg 2405041 aacgccgtca atgccataag tcatcaggct atagacatct tcttcggcaa ttcggtcaaa 2405101 aaacgccaag atccgtttaa gctcagcttc cgttttcaca ctcgttttcg ggaaagcaaa 2405161 cacgccgtta tggcctcctg atgcccatac ccgctctttc ccatctgggc cttttatgcg 2405221 gttgatgatc tcgagcttca tcgatttatc agaggcatgg tcgcgcagat tgaccgcatc 2405281 taccatattg ccaatataaa ttccggcttt tccttgagaa aacagctctt gctgctgggt 2405341 tttgcttgtg acgggaaaat ccttattcat atacccgtta tcacgcagct ttttcatata 2405401 gttcatcgtg tctttgtatt cctgtgtcat gaaatcaggc gtgaatttgc cgcccgattc 2405461 cttccaatct gtcggcatgc cttcatacga gccaatcgtt ttaaacgcgc cgtaaatcaa 2405521 gtcattacgg tctgccagcc cgaatgtatc atctttccca tccttgtccg ggtcgtcctc 2405581 cgtaaatgct ttggccactt cataaagctc atccaacgtt ttcggggttt tcaaatttaa 2405641 attgtccagc cagtccttcc gaatgacgat cccctgtctg gaaagcgggc gctctctgta 2405701 tatcccgtag agcttgccgt caattgtcac atttttatta atgagtttgt tcattttgtt 2405761 taagttggga taatccttga tataatcgcc gatttcccaa aacattcctg accgaaaggc 2405821 attcatgact gacgaatttt taatatcctg gatggtcacg atttgcggaa gattgccggc 2405881 tgcaagcgct gcattcagcc tgtcttcttt caccgcgtct ggaacccagg tgatgtcgag 2405941 ttctgtattt gtcagctttt caatttcttt aatcgccctg tctttcggcg gctgctggtg 2406001 atacaaaatc gccatccaag acagctttac ctttgaatct gggccagctt tgccttcagc 2406061 cgaagactga tcagttcctt tacagcccgc cagcactccg ccgagtgcca gtacaagcac 2406121 aatcaaaagc accctccatt tgtttcccat cgtacccctc cgtttcatat ttctttatcc 2406181 tttgacagat cccagcaaag ctccttttgc aaaatgcttt tgtataaacg gatagacaag 2406241 cagaacaggg atggtcgcca ccactatgac cgccatttta atggtttgct caggcggcgg 2406301 gctgcccgac cccatttcag acatatcccc ctgcataccg cttgatacaa tgacgatttg 2406361 gcgcagaagc acctgaattg gccattttgc tgaatcattt aagtacaaga tcgctgtcat 2406421 atacgtgttc caatacgtga ccgcataaaa tagtgaaatc gttgcgatcg caggaagaga 2406481 cagcggcagc acaattttaa agaatatgcc cagatcattg cacccgtcaa ttttcgcgga 2406541 ctcttccagg cttgacggga tattttgaaa gaagtttttc agaatgatca ggttaaaggc 2406601 attaatggct gtcggcaaaa taagcgccca gtaagaatcg agcaatccaa gcgatttgac 2406661 cacaaggaaa gtcggaatca tgccgccgct aaacagcatc gtaaatacga cgagaaacat 2406721 gagcggctgc cggccgatta aatcacggcg ggataacccg taagccatca gtgacgaaag 2406781 aaacatgctg accgcagtgc ctatcactgt cacaaacaca gaaacaagca aactcttata 2406841 aataatatct gttgaaaaaa tgtagcgata agcatctagc gaaaaagtgg tcggtattaa 2406901 aataaatttt ttcgacacga cttcttctac tgtggcaaag gatgctgcga taacatgaat 2406961 gaacggaagt acgcatatta aagcgaacat cagcaagaaa ccataaatca acatatcaaa 2407021 cagacggttt ttcagtgaat gtgcgatagc tcccacctcc ctttgtaagc gttatcatat 2407081 ttttggaaac cgagctcagc atgtgacgat atcgtgtcta aaatgtagca aatctgtgat 2407141 tgccatgtct ataatcattt gaacagtgtc cccggccggg cgggggctgc cgcgaattga 2407201 gaccgataac aaaagaaaaa gagcataatc ttagaaaatg attatgctcc gttctcctcc 2407261 tcgttcagaa gttcagccgt attgatttgt ggcgaaaacc caagttcatt cacggcagat 2407321 tcaatggacc atggccggcc cggattatca gagacggcgt aataagtgcc ataccggatg 2407381 ttggtctcaa tggcggcttt gaaaatcgac agcagatcgg ggtgagaaag cagtgtcttt 2407441 ttcgtccgtt ctttttcatg cagcgtatcc atttcatctg tcacgactgt tccgattcga 2407501 aggttgatta ctgatagctt attttccaaa taaaacaaat ggccgatctg ttcagaggtc 2407561 agctttaata caccgtacaa gttttttgac agcggataat cgcttgttgt gatttcccgt 2407621 cctaagagcg agcgcccgtc tttttcatat acatctgtga catgattgct gctggcgaac 2407681 acgagctttt gaatgccgag ctccgctgcc gcacggcaca gataatagct tgccctatag 2407741 aaaacatccg tcattttttc aaactcagcg atgtccataa tatcgtattt gattttcaca 2407801 gcgagtaaat tcaagatggc atcggtatct tttggaatct tcttcaacag ctcctcataa 2407861 tttgccgcgt cagcctgaat ggaagaggct ttgccatcga aatgatcttt atcaagcaca 2407921 gtcacttcat agtctgaaat aagcccttca gcaagcagtc tcccaatcac accatttccg 2407981 ccggcgatca gcactttttt cacgatgttc actccccttt tttatagatt gcccattttc 2408041 ggcggggctg acactttttt ggcactcaca ttcttaggct tattcaaaag tcaccggcag 2408101 ctcctcaagc gcccgaaatc caaaaagcgg ccgataccgc cattcaaaat ccgcaagatt 2408161 aaggctgggc attcgctgca gaagagtgtt aatcgcaatt tgcgcttcta atcgtgccag 2408221 cgaggaccct aagcaaacat gatggccatg cccgaatgaa agatgcggat taggacttct 2408281 cgtaatatcg aagacatcgg ggttcgtgaa tatgctaggg tctcgattag ccgctcctaa 2408341 caaaagatag acttgttctc cttgacggat cgtcaccccg cagatgtcaa tatcctctga 2408401 cgcaactctg gctgtcattt gcgtggggct ttcatagcgt aaacattcct cgactgcggt 2408461 accaataaga tctggatttt ctctcagttt caaaagctgt tctggatgct gcagcagaca 2408521 aaggactgaa ttgctgatga gattgaccgt tgtctcatgt ccggcgatcg ccagcaatat 2408581 gcacgtagat gccgcctcct cttccgtcag cttatccttt tctctcccct tcaagagcat 2408641 gctgatcata tcctgttgag ggtggcgttt tctcttttga atcagctctt tgaaatatgc 2408701 catagcctgc acagccataa tattgccctc tgttaatgcc tttcttgagc gggtaaaatc 2408761 aatcgtttga atgagactcg cagcccactc ctttaattgc tccctatctt cctccggtac 2408821 acctataatg ttagctatga caaaacttgc taaaggaaaa gcaaagtccg aaatgacctc 2408881 catctttttt ttaccttgca cttgatcaag caaatgatgg acagtttcaa tgatatacgg 2408941 ctgataactc tctgtcgttc tcggcgtaaa cgctccgctg gcaagcgtcc gcaatcgtct 2409001 atgatcaggc tggttctgaa acagcatcat ttgattttgc acatgtgaaa ggtcctgata 2409061 tttggttgag ctctcaggca gcggggtgcg gactttgaat ctcgcatctt tcaaaatagc 2409121 agccgtttct tcatatcctg tgacatacca gcccgggtat tttaagaaac tccctttata 2409181 gataggatga acagctcgca atgtgtcgta aaaagaatat gggtttttca aaaactcaga 2409241 agatgcagtt gacgatgcaa ttgtcacgtg attttctcct ttctgttcaa aaataaaaac 2409301 aatcgacatc ataccgattg cttttattga ttctttcagc ttttcgcact taaactagcc 2409361 ttcatttctt cgactgattc aacttcaaag cctaaatcac tcagcatttt atgatcctcc 2409421 gtctcctctt gcccggcagt tgttaagtag tctccgacaa aaatggagtt tgcggcgtaa 2409481 agccctaatg gctgcaatgt gcggagattg acctctcttc ctccggaaat gcgaatttct 2409541 tttgatggat tgataaaacg gaacagcgcc agcactttta aacaatacag cgggtttaat 2409601 tcgttgacgc cttctaacgg cgtgccatca attgcatgca aaaaattcac aggaatggaa 2409661 tccgcgtcaa gagccttcaa gcttttggcg atgtcaatga catcctgttt cgtctccttc 2409721 atcccgataa tggcgcctga acacggagac agccccgatt cttttgcgat ttcaaccgta 2409781 ttgactctgt catcgtatgt atgtgaggtt gtgatgtttg aatggtttct ctgtgacgta 2409841 ttcaaattat gattatagcg gtctactcct gcatctttga gccgcttcgc ctgctctggc 2409901 ttcaacagtc caagacatgc acaaatcttc agtccatacg tctctttaat ttcctgaacc 2409961 gcatctacga cctgatccac ttctctgtta gacggacctc tgccgcttgc cacgatacaa 2410021 tatgtgccga tattcagatc gtgcgcccgc ttcgcgcctt caagcagcgt ttccttattc 2410081 accatccggt aagactcaat cggcgctttc gaaatcgcag actgtgaaca atagccgcag 2410141 ttttccgggc agagcccgga tttcgcattc ataatcatat tgagctttac tttttttccg 2410201 taaaagtgtt ttctgatgtg aaaagccccg tgcattaata gcaaaatatc ttcatcagga 2410261 caatgtaata ttgaaagcgc ctcttcgtca gtcacttctg ctccagccag cacccggtct 2410321 gcgagttcca tccattgatt cattctcata cccccacttg attcatcagt aatgatagat 2410381 tgatatggtc ttttaccata tgtagaaccg tttctttcgt cacgttggca agctttggcg 2410441 taacccctaa aatcggcaca ccgcataagc gctcaatcat ctcaggattg gttttttcat 2410501 cttcatcagg agagtcactg attccattga tgataattcc ggcgattgga agccccatgc 2410561 tttctgcata tttgacagtt aaaaaggtat gattaatggt tccaaggcga ggacgcgcca 2410621 caataatcat gggaagctgc aacgctttta tgacatgact gaccaaatag tcctctccca 2410681 atggcacaga aataccgcct gcaccttcta cgatgaagca ttcatgtttt tctctaatcc 2410741 gcccccaatg gcttaaaacc tcttccatgg tgacagtctt tccctcaagt ttccctgcaa 2410801 cgtatggtgc aagcggcgcc ttgaaggcaa aaggcgtaat gtcttcatga gaaagactgg 2410861 tctgcgacat atctttcagc aaacttgtat cactatctgg atgatggcgc gatatcccgc 2410921 ttaaaaatgg tttatacacc ccgacatgtc tattattgtc tttcaataag gcagcaagac 2410981 cgctggatat aaccgttttc cctacttctg tatcagttcc cgtcacaaaa aaacccctca 2411041 aatgatgtgc agctcctttc cgattgaatg aaatgtttgc agcaaatgat caatatcacc 2411101 catactgtgg tcagacgtga ttgtaattcg aatccggctt tcacccggcg caacggttgg 2411161 cggccgaatg gcaggagcat aaattccctt gccctgcagt ttttcagcaa ataggaccgt 2411221 tttatgggca tcgccaatga ctacaggaat aatcggtgtg tgatctcctt tcaccacata 2411281 acccatattc ttcagactgg ttctgatcat gctgatataa gaaaataaaa gctgtcgttt 2411341 ttccctgctg gcttcaatga tgttgaaagc ctcgtgagca gccgcacagc tggctggcgg 2411401 aatagcggtt tgaaagataa atgttctggc atggttcagc aaaaagtcga tgaagaccgc 2411461 tgatcctgcc gcaaaacctc cttccgcgcc aacagctttg cttaaggtgc cgataacaat 2411521 gtcgggacaa acaccaaagt attcactcgt tccttgtccc gaatcgccca aaactcctgt 2411581 tgcgtgggca tcatcaacga ccacgaaggc atgatagcgt ttcgcaagtg agatgatctg 2411641 atcaagaggg gcgattgtgc catccatgct gaatactccg tctgttacga taaaacggcg 2411701 ctgataacgc tgtgtttcat tcagcttgtt ttcaagatca ttcatatcaa tatgccgata 2411761 aacaactgta tcagccttag aaagtcggca gccgtcgatc atacttgcat gattgagctg 2411821 gtcacttaaa atgacatctt ccttttctgg caaggatgaa aggacaccga cattggccaa 2411881 gtaaccgctc gaaaacagca gggccgcttc tgtcagttta aagctggcaa tcttcttttc 2411941 tagcttttca tgccagaccg aattgcctgt cgttaaacgt gaaccgctgc ttcctgtccc 2412001 aaattgctgc aatgctgttt gggctgcatc gatcaaacgt ctatcgcttg cgagccctaa 2412061 ataattgttt gaggaccaga ccgtttgatt ttcgccatca atattcctct ctggaaccgg 2412121 cgctccatcc attgaccgca ggttacgatg tacgccggct tctttcattc tgtctaaccg 2412181 ctcgtttaac caggaatcaa tcttcaaggc tcgtaacctc gtggatcgct tgtttcataa 2412241 tggcaaccat ttccgagagc tcttcagctg tgctggcaag aggaggaaga aatgcaatca 2412301 cgtccccaag cggtcttgtc agcattccta actctctcat ttttaaggaa actttgtatc 2412361 caatccgccg atcagccggg taaggttctt tagtttcctt tgatcgtaca agctctgcac 2412421 cgcacataaa gccaagctgc cgaatatccc caacatgagg aagagcgtgc agatcttgaa 2412481 gaagaaaatg gagcttttta cttttttccg ctacttgttc cacaatgttt tcagattcaa 2412541 ataatgccag attttcaagc gcaaccgcac agccaagctg attgcctgta taggaatggc 2412601 catggaaaaa ggtttttagg ttttcataat catcatagaa tgccttatag atgtcttcag 2412661 tggcaaacgt aacggcaatt ggcaaatagc ctcctgtaat gcctttaccg gcagccatca 2412721 gatcaggctg gacattctcg tgctcgcacg caaacatttt tcctgtacgg ccaaagcctg 2412781 tagcgacttc atcaacgatc attaagacat cgtatgttgt acatagctcg cgcacgcctg 2412841 ccaaatatcc ttccggcatc acgatcatac cggacgcgcc ttgtaccatt gattcaatgg 2412901 aaagcgcggc aatttcctca tgatgttcct caagcagctg tgcaagctct cggaggcact 2412961 gatcacggca ctcatcagga tcaccgcttt cagaacgata cacataagga atcggggcct 2413021 tgtaactctc gaacatcaac gggccgtata cgtggtgaaa aagctcaatt gaaccgacac 2413081 tgacggcgcc aatcgtatca ccgtgatacc cgtttttcat tgcgatgaat ttttgtttct 2413141 cgggcttccc gatgttcttc caatactgaa acgccatttt tagggctatt tccatcgcct 2413201 ctgcgccgct gtctgaataa aagacccgcg tgagcttttt tgggctgatg tcgattaatg 2413261 tttcggcaag ctgggttgct ggaacattgg tcatgcccaa taacgtggag tgcgcaattt 2413321 ttccgagctg tttttttatg gcgtcatcta gttctttttt gcggtgtccg tggacattaa 2413381 gccaaaccga tgaaaaaccg tcatagtatt ccttgccgtt tatgtctttg actttgattc 2413441 cagtcccgct ttcgatgatt aaggggtttt catcataatc tttcatttgg gtaaatggca 2413501 gccagaggtg ctttttactt ttttctatca aatcatgagt catgatcttc ctcccactct 2413561 attaaaatag gctgcttctc caggtcatgt atgtacgtgt ttacatcatt ggatccatca 2413621 ataaaaaaga ctcggcagcc ctcttcagtc ccgtattctt tcattgctgt aatacgctga 2413681 tagcccattt tcttacccgc aacatagcct gttatgtaat ccggatcgtc cgaccagcat 2413741 aattctgcaa cgactgccgg gtgccggctt acctttgaag cgagcgcaag ggcctctttt 2413801 attcttgaat gagctggcac gtgactgtga agcgcccatt tttcaaaatt agcgtccggc 2413861 caatccattc tggagacccg cacccctttt tcttttgttt gatccattcg cttgcctgta 2413921 tgaatatcaa acaacaccgc acccctgaca tctgaccatt cagggatttg ttcatatgct 2413981 ttttcaatca cgtctcgtga aacgccttct ttttccaata acaatcgggc aagcttttgt 2414041 ccttcttccg ggcagctcac ttcattcgta tgcacaggca atggctgaat ggtttttatc 2414101 gattcatgta cctcttcaaa ttgaatttgc ataaaatcag gttttcctct tgaatgggat 2414161 aacccttttt ctaataaagc attgactgta tgcttcatct catggaaagg aataagccgt 2414221 tctccgccgg atatatgctt tccgccgtct tcatgagatc cattcattga agccctcatt 2414281 ctgacactat aaaaagtttc ttcttgcatc atttctcgcc ctttcactga taactgaaga 2414341 acgtgtagcg cttctcacct aaattgttaa ccaattatat tcaaaggtta acaattagaa 2414401 tatattattc tctcctgttt ctgtcaatag aagaaaggat cgatttatgg cagttggtta 2414461 aaaggaaaca aaaagaccgt tttcacacaa aacggtcttt ttcgatttct ttttacagtc 2414521 acagccactt ttgcaaaaac cggacagctt catgccttat aactgctgtt tcgaaatgtc 2414581 ccgaagcaga acggaccact cggtagcaat cagcagctcc ctgtccagca tagacagctg 2414641 tcaattcttt ttcgattttg tccacgccct cagccggcgt taaccgatcg tgtacaccaa 2414701 caagactaag gtgcgggcgc ggcgcgatca ggctttggat ctccgatgcg gaaaaatgct 2414761 ttgcaagcga tgggacgtaa taataaaagc cgtgcctgtc aagattctgt gttttgatca 2414821 gcacgtgatg atccacctgg ctgcacaaat ccacacacac cttaatccgg tcatcgagcg 2414881 ccgctgtcca ccacgccatc aaacctccca tagacatgcc gatggttccg atcctgtcag 2414941 gctgaacatc agagcgtgac tgcatatagt ctaacgcact taaactgtca taaatcatca 2415001 tcccccacat cacttttccg gtgagaagca tttctttaaa tatctcgctt tccgcttttc 2415061 cccgccgatc tccaaacccc caatgatcaa tcgcaagaac gccgtatccg agtgaagtaa 2415121 gctcatcaga aaaagaaggc gttttcaaat aatccgctcc ctcaatcagc tcactttttc 2415181 ccctatcata ctggcctcca tgcgaatgct gaaacaatac ggctgggcac ggtccttctg 2415241 ttttcttcgg cttcacaaaa taagcgggcg ccttttcatg tccatttaaa tcgagcagga 2415301 gcgtttcaac gatattttct tctctttctt caatacgtaa tgtctcaaca ctgattggcc 2415361 tccgatcagg caaatcacca agcaatcgaa acagttgctt tcttctttcg gctctcatcc 2415421 catcaccctt ccttattcgc ttacttcaca tttacgagac agatctgggt tcccctttat 2415481 ttttccaaca taaatcacat catttactaa atatttagta aatattatgg aatatttcga 2415541 aaacaattat tgtaaccgct tacttttata tgataatatc aatttatcaa aaacagatga 2415601 gttaatattt tactaaatag atgagaggga tacccatggt tcgtattaaa gatatcgcct 2415661 tgaaagctaa agtttccagc gcaactgtgt ccagaatttt aaatgaagat gagtcgcttt 2415721 ctgttgcggg cgaaacgaga caaagagtca tcaacatcgc tgaagagctt ggttatcaaa 2415781 ccgttgccaa acgccgaaaa tcccgcgggc aaaaacagcg ggctcagccg ctgatcggtg 2415841 tgctgagctg tctgtcccct gatcaggaaa ggcaggaccc ttatttttct tccattcgga 2415901 aagggattga aaaggaatgc tttgaacagg aaattttcat tacaaattcg attcatctcg 2415961 gctcctttca ggaacatatc tttcgggaat tggatggtgt cattgtcatc ggccgtgttc 2416021 atgatgaagc ggttaagcat atcagcggga ggctggagca tgccgtattt atcaatcatt 2416081 caccagatcc gcaagcatac gattcgattg gcatcgattt tgaatcggct tcacgccagg 2416141 cgattgatca ccttttcgac ttaggctaca aacggttagg ctacattggc ggacaagaaa 2416201 aagagcatac gctgaaggac ggccaaagca ttcgcagaac gattgaagat aaacgcctga 2416261 ccgctttttt ggagtcagcc gccccccagc ctgagcatgt gctgatcgga gaatacagca 2416321 tgcgtgaggg ctatcgcctg atgaagaaag caatcgatca aggccatctg ccggaagcat 2416381 tctttattgc cagcgattct atggcgatcg gcgcattaaa agcgctgcag gaagccggac 2416441 tgcaagtgcc gcgggatacc gcaatcgtca gctttaacgg cattgaggaa gctgaatttg 2416501 ccagcacgcc tttaacgacg gtgaaggtat acacagagga aatgggccgg acaggcgtaa 2416561 aactgctgct tgaccgtctc aatggccgaa cgcttcctca acatgtcacc ctgcctacaa 2416621 cattaatcgt aagacaaagc tgcggatgta cagcaaagga ggtgacataa gcaaagattc 2416681 atcacgatga taaggaggaa aagatgaaac acacttttgt tttatttctc tctcttattc 2416741 tgcttgttct gcccgggtgt tcagcagaga aaagctcagc agataccgca aaaaagacgt 2416801 taaccattta ttctacaatg tcaaccgaca gtgaaagaga tacgttcaga aaactagcgg 2416861 cagcattcga aaaggaacac agtgacattc atgtcagcct tcatttccca ggcaatgact 2416921 atgaaaatat gatgcgtgtc agaatggcgg ccaatgattt gccagatcta ttcgatacac 2416981 atggctgggg gaaaatcagg tacggagaat atacagcgga tctccgggat atgaaatgga 2417041 ctcaagatct tgatcccaat ttaaacagca tcctcaaaaa taaaagcgga aaggtgtatg 2417101 cctatccaat caatcaggca aaagacggtc tggcgtataa tcgcaatatt ttagaccgtt 2417161 acggcattgc tccgccggaa accatggatg actttatcaa agcactgaga acgattaaag 2417221 aaaagagcaa gggaagcatt gttcccttct ggtttgccgg atatgacaaa agctcattcg 2417281 cccaatatta cgaccaattc gctacacctc ttctcatcac agaccctgcc cataatgaaa 2417341 aaaaacagct catcaacggc acttttcaat ggagtaaatt cacttattta tcagaaatcc 2417401 tcaaacaaat gcagaaagaa aaattgatca atatcgacgc cgtcacggca aaaaaatcac 2417461 agctcattga attaatggcc caaaacaaaa tcgcctttac aatgcaaggc ggcacactcg 2417521 gccaagacgt tgcccagatc aacccgaacg tcaaggtcgg cattatcccg acacctgcca 2417581 tccatcccgg tgatgacccg atatggatcg gcggtgaacg ctacaccctt gcagcatgga 2417641 aagattcgcc tcaattaaaa gaggcaaaag attttatcgc atttatggcc cgcccggcca 2417701 atgccaaaca aatggctgaa gccacatcgc ttccttcagg gctgaccaat gtgaaagctg 2417761 atattttcta cgcaaacgat tatgagtatt atcaagatgt caaagtcgag ccttacttcg 2417821 accggttata cttgccaaac ggaatgtggg atgtcctggg cacggttggg caggagctcg 2417881 cggctgacat tttggcgcct caagacattt cgcagaagct gggaagagaa tataaacgac 2417941 tccgggagca atccgaaaca cagggagctg aaaacaatga gtgagatcgc aagggacgtt 2418001 catgtgaaac aggttaagcc aaaaaagcag tcctcacttt ggtggatgta cattcctgct 2418061 ttgctctccg ttctggtctt tatgatttac ccgtttgtga aaggcacatt gattaccttt 2418121 acaaactgga acggattttc acaagtctac caatgggttg gattcgcgca atatgaaagg 2418181 ctgttttctg atcctgatac ttggcatatc ttaaaaaaca cgctgcatta cgggcttggc 2418241 agcacctttt ttcaaaatgt ggtcgggctt ctgtacgctc tcctcttaaa tcaaagcatt 2418301 aaaacgaaag cggtaacaag aacaattgtg tatttgccgg tgatgatcag cccgctcatt 2418361 atgggctaca tttggtactt tttcttctcc tatgacggag gcgcgctcaa cgatttgctc 2418421 ggggtcttcg gcatcagccc tattaatgcg ctcgccagtc cctcgctcaa tccatggatc 2418481 attgtcatga ttaacaccta tcaatatgtc gggatcgcta tggttgtcta cttagccggt 2418541 ctgcaaagca ttccgaaaga ctactatgaa gcggcgcaaa tggatggcgc gaaacaaggc 2418601 cagcagtttt ttaccatcac gctgccgctg ttaatgccct ccattaccat taatatagtc 2418661 atcaacatta tcggaggctt aaagctgttt gacgtcatca ttgcactcac cgcaggcggc 2418721 cccggaaatg cgtcacaatc catgtccacg tttatgtatg atttgtattt caaacggcag 2418781 gatgccggct atgccgcaac gcaaggcata tttatggcat ttgtcatttt gatcatcagc 2418841 ttttgcgcgc ttgcgtactt taaaagaaag gagacggaaa tgtcatgaga gccgcccgta 2418901 caaaaagcat gcggatcatt acgcttcttg cagccattgt ggcctgtgcg cattttattc 2418961 ctttttatat cctgctgacc acttcattga aagcaaaagg agactacagt tcgaaatgga 2419021 tatttccagc cgacatctcc tttcataatt tttcagaggc gtgggagcgc gcttcgctag 2419081 gaaactcttt tataaacacc atgatcatca caggtttttc tgccttgtta ttaattatat 2419141 tcggctcact tgccgcctac ccgcttgccc ggcgggaaac gaaactgaat aaagccgttt 2419201 ttgccttgct gatttccatt atgatcatcc ctccgttaac gtccatggtt cctttgtacc 2419261 gaatggtcgt ggacgccgga atggtcaata cacacgcaat cgccattttc atcaatacag 2419321 cggcttacat gccgttaacc gtattcttat attcaggctt tatccgatcg accattccaa 2419381 aagagcttgt agaagccgca agaattgacg gtgcaggcat gctgaaaatc ttttttacga 2419441 ttgtgtttcc tctgctgaag ccgatcactg cgaccatctg tatcatttct tgtgtcttta 2419501 tttggaacga ctatcaattt gccattttct ttttacaaga tcaaaaggtt cagacattaa 2419561 cagtagccat ggcaggtttt ttcggagaaa acgcaaacaa ccttcattta gttgccgcag 2419621 cggcacttat ggcaatgctg ccgatggttg ttctgttttt ggcgctgcaa aaatacttta 2419681 ttgccggcct gtcttccgga gcggtaaagg gttaacatta aagggggaag caatatgaaa 2419741 aagattacat ttatcggtgc agggagcacg attttcgcca aaaatgtttt gggagactgc 2419801 ctgttaacag aggcactgaa tggatttgag ttcgctcttt acgacattga tcccaaacgc 2419861 ctgcaggaat cccagctcat gctcgaaaat ctaagagacc gttataaccc aagtgtggcc 2419921 atcaacagct atgatgacag aaaactcgcc ttgcaaaacg caggctatgt catcaatgcg 2419981 attcaggttg gaggatacaa accgagcaca gtcatcgatt tcgagattcc taaacggtat 2420041 gggctgcgcc agacgatcgc cgatacagta ggcatcggcg ggatattcag atctctcaga 2420101 acaatcccgg tcttatttga tatcgcaaaa gatatggagg aaatgtgccc tgacgcatgg 2420161 ttcttaaact atacaaatcc aatggccact cttacaggcg ccatgctccg ctataccaat 2420221 atcaaaacaa tcgggctctg ccacagtgtt caagtgtgca cgaaggattt atttaaagct 2420281 ctcggaatgg agcatgacgg aattgaggaa cgcattgcgg gcattaatca tatggcttgg 2420341 cttttggaag tcaaaaaaga cggcacagat ttatatccag aaatcaaaag gagagcgaaa 2420401 gaaaaacaaa aaacaaagca tcatgatatg gtgcggtttg aattaatgga taagttcggc 2420461 tattatgtca cggaatcgtc cgaacataac gcagagtatc acccgtactt tattaaacgg 2420521 aattaccctg aactgatcag cgagctgcaa atcccgctcg acgaatatcc gagaaggtgc 2420581 gtcaagcaga ttgaaaattg ggagaaaatg cgggatgata tcgtcaataa taaaaacctt 2420641 acgcacgaac gctcaaagga atatggttca agaattatag aagcaatgga aacaaacgaa 2420701 ccattcacct tcggaggaaa cgtcttgaat acagggctga tcaccaacct tccttcaaaa 2420761 gcggttgtgg aagtgacatg cgtcgccgac agaaaaaaaa ttacaccgtg cttcgccgga 2420821 gaactgcctg agcagcttgc agccttaaac cggacgaata ttaatacaca gctgatgaca 2420881 atcgaagcgg ctgtcacacg aaaaaaagaa gcggtttacc aagctgcaat gcttgatccg 2420941 catacaagcg cggagctttc catgaaggac atcatctcca tgtgcgacga tttatttgca 2421001 gcacacggcg attggcttcc ggaatacaaa taaaaactag gggaccgctc tcccctagtt 2421061 ttttggtttt gtttcgcctt cccaggccat catgccgcct tcaacattga ctgttttaaa 2421121 gccttgctca tccaggtact tgcagacgtt catgctgcgc attcctgagc ggcagataaa 2421181 tacgtactct ttgtctttat caagggtttc cattttttca ggaatatccc ccatgcgaat 2421241 atgaacggct tgcgggatca tgccttccgc tacctcttca tcttctctga catcaattaa 2421301 atataattct tcgtccgcct caattttttc tttcaaagcg gctgtgctga tttcttttat 2421361 ttccaaagaa aacactccta ttcacagtga tcatgttcag tatatcaaag tcagccgaac 2421421 gattgctatt ctgagactga tgaaaaaaaa tccccttttg gcaaagggga ttttttctag 2421481 gcttagtttg ccacaatatt gacaagcttc ccaggcaccg cgatgatttt ccgaatcgtt 2421541 ttgccttcaa gctgctcttt gaccttttca tctgcttgag caagctgttc cagctgttct 2421601 ttcgttgcat cggcaggaac ctgtaatttc gcttttactt ttccgttcag ctgaacaacg 2421661 atttcaactt catcatccac aagttttgtt tcatcatata caggccaagc ttcgtaggca 2421721 attgtgccgg aatggccaag cttctcccat agctcttccg ctaagtgtgg cgcgacagga 2421781 gaaagaagct tcacgaagcc ttccatatat tctttcggca gttctgttgc tttataagct 2421841 tcattaataa agaccatcag ctgggaaata cccgtgttga aacgaaggcc ttcataatgg 2421901 tctgtgactt tcatgaccgt ttcatgatag acgcgctcca atgtttcacc cgcgccttca 2421961 acgatttttc cattaagctc accgctgtct tcaataaata ggcgccatac acggtcaagg 2422021 aaacggcgcg caccgtctaa tcctgattca gaccaggcga ttgaagcatc aagaggtccc 2422081 atgaacattt cgtacaatct cagcgtatca gcaccgtgag aggccacgat ttcgtcagga 2422141 ttgacaacgt tccctttaga tttactcatt ttttcgttgt tttcgccgag aatcattcct 2422201 tggttgtaca gcttttggaa cggttctttc gtcggcacta cgccgatatc ataaaggaac 2422261 ttatgccaga agcgggcata cagaaggtga agcacggcat gttctgcacc gccgatatac 2422321 atatcgaccg gaagccattt ttccaatttt tctggtgatg ccagctgatc cggattgtgc 2422381 ggatcaatat agcgcaagaa ataccagcag cttcccgccc attgcggcat tgtattcgtt 2422441 tctcttcttc cttttttccc tgtctcaggg tctgtgactt ccacccactc tttaatgttc 2422501 gcaagcggtg attcgcccgt tccgctcggt ttgatttcat ccgtttttgg caaaatcagc 2422561 ggcagctcct cttccgggac agctgttgac gttccgtctt cccaatgaat gaccggaatc 2422621 ggctcgcccc aataacgctg gcggctgaag agccagtcac gaagacggta cgtcactttc 2422681 ttctcaccgt ttttcgtttc ttccagccaa gcgatcactt tttcaatcgc ttcctgtttg 2422741 tgaaggccgt tcaggaaatc agagttcacg tgctcgccgt cgccagtata ggctgcttcc 2422801 tcaacgttcc cgccttttac gacttccttc accggaaggc cgaatgtttt ggcgaattca 2422861 aaatcacgct catcgtgtcc tggaactgcc atgacagcac ctgttccgta tgatgcaaga 2422921 acataatccg caatccaaat cggcagtttt tctccgttta caggattgat cgcatacgct 2422981 cctgtaaata cgcctgtctt tgttttcgca agatctgtgc gttctaggtc actctttgat 2423041 tgaatttctt tgatataagc ttcaacagct tctttttgct ctgccgttgt gatgttttcc 2423101 accaatgcgt gttccggggc aaggacagtg tatgtagcgc caaacagcgt atctggtctt 2423161 gttgtaaaca ctgtaaagga atcatcatgt ccatctatag caaaatgaac gtgagcgcct 2423221 tccgaacggc cgatccagtt gcgctgcata tctttaatgc tttccggcca atcaagctct 2423281 tccaagtcct caaggagcct gtccgcataa gcggtgattt tcagcatcca ctgcttcatt 2423341 gggcgtctct ctaccggatg gccgccgcgt tcgctcttgc cgtcaatgac ttcttcgttg 2423401 gcaagaacag taccgagcgc agggcaccag tttacaggca cttcgtcaac gtaagcaagg 2423461 cctttttcgt atagctttaa gaaaatccat tgcgtccatt tatagtattc agggtcagtc 2423521 gtattgattt cgcgatccca gtcatatgag aagccaagcg cttgaatttg gcggcggaag 2423581 ttatcaatat tctgcttcgt aaacacagcg gggtcgttcc ctgtgtcaag cgcgtactgt 2423641 tcagctggca ggccgaatgc gtcccagccc attggatgaa ggacatcata gccctgcatg 2423701 cgcttcatgc gggacagaat atccgtagct gtgtatcctt caggatggcc gacgtgcaac 2423761 ccagctccag acggataagg aaacatgtcc agcgcgtaaa atttttgttt ttcattatta 2423821 tcaagagtgg caaatgtttt gttttcaagc caatatgtct gccatttctt ttctatctct 2423881 ttgtgctgaa aactcaaagt aaaaacctcc ttctgattga atacggcgtg tatggttcaa 2423941 gtattgacgg gaaggagagg attatattca gaatattccc aaactaaaaa aaactccctc 2424001 atcccaaaaa gggacgagag actttcgttt tcccgcggta ccaccctcgt tagcgcggca 2424061 tacgccgcac tcacttgata cttttaacgc agttatgcgt cagcggcttt tcaccgctgc 2424121 aactctgagg tgagttcgga aacaaacttg attgactttc accagccgtc aactctctgc 2424181 aacaatatct gtttcttact gctcctcttc attgttctta tcgcaaccgt aatctaactg 2424241 tattttatag aattctgttc ataagtgcaa gcaggtttgt atacaatggg aatgtaccct 2424301 gaacgggcgg agattgagga caattattcg ggtggagttt tggtttgacg tttggactcg 2424361 gccggttcgc cgccgctgtt cagttctctc acaaagtcaa aacttctgag aacagcttca 2424421 ccgccgtagc ctgagataat ggataagatg acaagttgaa ttcctgaatc ggggtcagcg 2424481 gataatacaa gtaaaatgga agccgtcatg ccgataaacc aatcttccaa aaatccaagg 2424541 tagataaacc gcttcgtcat tctgggcttc tccagcctgc ctctcttttt cacatgaccg 2424601 agaatcccca tgattcctcc aattacacaa gcaatgagta cctgatgcag catcttcatc 2424661 atcaccttcc taaagccctt atttcgtaaa gcgacttcag gccatccagc ccccttaaac 2424721 gattccgatg attttcgata tctacatacc ggcaaatctg taaaaagctt gtttcttcca 2424781 ttatatgtga acacatgatc ggtaagcttg atgcattgga ttcatttttc acccagtgac 2424841 attgacctag tcacctattt agcatgtaga aaacctttcc gttcatatgt tcaaattctg 2424901 ttcttatttt tagtgtatac gaggacaagc cctaatgaca aacaacaaac tgcacttgct 2424961 tgaatcagaa catgtgttgt gctacggtta ctgtagaatt catttttaaa aaggggaata 2425021 tcaggctttc gcatagcaag ctgacggcct aagggggatt tatatggcta gttttcaatc 2425081 atttgggata ccaggacagc tggaagtcat caaaaaagca cttgatcacg tgcgagtcgg 2425141 tgtggtaatt acagatcccg cacttgaaga taatcctatt gtctacgtaa atcaaggctt 2425201 tgttcaaatg accggctacg agaccgagga aattttagga aagaactgtc gcttcttaca 2425261 ggggaaacac acagatcctg cagaagtgga caacatcaga accgctttac aaaataaaga 2425321 accggtcacc gttcagatcc aaaactacaa aaaagacgga acgatgttct ggaatgaatt 2425381 aaatattgat ccaatggaaa tagaggataa aacgtatttt gtcggaattc agaatgatat 2425441 caccaagcaa aaagaatatg aaaagcttct cgaggattcc ctcacggaaa ttactgcact 2425501 ttcaactcct attgtcccga ttcgcaatgg catttcggct cttccgctag tcggaaacct 2425561 gacagaggag cgatttaatt ccatcgtttg cacattgacg aatatcttat caacatccaa 2425621 agatgattat ttgatcattg atttatccgg attggcccaa gtgaacgaac aaacggccga 2425681 ccaaattttc aagctgagcc atttgctgaa attgaccgga actgagttaa tcattactgg 2425741 cattaagcct gaattggcta tgaaaatgaa taaactggat gccaattttt cgtcgctgaa 2425801 aacatattca aatgtaaagg atgccgttaa agtgcttccg attatgtaaa aagatcccgc 2425861 tcacccagct ggatctttca gattgttgac aaaatcctaa aatggttttc attttaggat 2425921 tttgtcatct tttcagcgtg attgaaaacc cttgaagtct aggaaggacg agcataggag 2425981 cggagcgaat gttctaattc gtgagcaccg aagcgcaggc ctgacaacga atgcgagggt 2426041 ttgtcgacac gctgaaagat cccgctcatt cggcgggatc ttttattatg aagagattga 2426101 tgcctgctta tttgtttctt tagctgattt tatccgtttg tcatatagaa gcgttgtggc 2426161 aatactgatc agcagcaata ccaacagaga taaaacaaga gccctaatgc cgtaatgatc 2426221 gacaagcact cctccgaaca ggggaccaat cattctgccg cctgtcgccg cactgttgac 2426281 aaagccttga taaaagcctt ctttcccttt aggggcaagc tgattggcaa tagtcggcac 2426341 agcaggccaa acaagcattt ctccgatagt caggatcacc atcgcagcga gaaacatcgg 2426401 aaattgcttt gcagtcagca gcatgctgaa agacacaata aaaatgataa agccgatgac 2426461 catttgcgct tttagcgact cggcccattt tttcaccaca aaactgacga gcggctggcc 2426521 gagcacaatg agaattccgt taaccgtcca cagcacgctg tataaggaaa gagatattcc 2426581 aatgctttgt gtgtacgaag caattgtggt tgaccactga gaataagcca gccatccgag 2426641 tacatagcct ccgcttaaaa tgatcagtgc ggcaaatttt gctttgctgt tcacagcatc 2426701 ataatcaagc acggatgttt gggatgcatc gcccgtttga atatttcgaa atccgaaata 2426761 tacaataaag aaaaagatca gatacaatac ggcatttgcc aaaaatacat atgaaaacga 2426821 gaaagatgcc acgacaccgc caagcgctga accaacggcc acgcccgcgt tttgcgcgac 2426881 atatatcgca ttaaatgcct tccttccccc ttcaggccat accgatcccg ccattgcgta 2426941 gcttgccgga aaaacaacac cggagccaaa gcccacaatc gtcagcagca caatataggc 2427001 tggccaatca tgaaaaaaga caagacccat caggcttgct aacgtaatgg ctatcccaag 2427061 cataatcgat ttaaaaccgc cgattttatc aaacaaaaaa cctccgcata aattgccagc 2427121 cacactggcg ccggaattca gcatcaggac aagtccggct actgttaacg actttcctaa 2427181 atgattatgg atataaatcg tattcagcgg ccataaaaaa gaagcacccg tcacattgat 2427241 aaacattcca atgactaaaa ttttaagagc acgcggcata ctcatccccc tttcttacct 2427301 aaaaaagctc atgaaaaaaa cgaaacctaa aacggctccg tacgaatcca gttatcatag 2427361 cacattcatt ctatctgtct ctctcacatt tttcaactga tgagcgtgaa aaaatctaac 2427421 aaatattgtt tgaaaaatgt aaaataaata gaaaaagggg tcatattatg gaaatggtat 2427481 tagcattctt aggttttctg gcatgtctca ttgcactggg ctatggatta tatcaccttg 2427541 tcagatatgt actgaaaaag gaaaaacgtt tctcaaagag acttttttgg ccgcttttca 2427601 ttggaggcct tgtgctgctc tttaccgggg cagcattggc agaacctgac actgccgcag 2427661 caaatgccga gaaaaaatat tcagcgctaa acgccgaata taaaaacctc acaaaagagc 2427721 acgaagaact tgagaaagaa tataaatctg tcagctctga agcaaagaaa ttaaaagaca 2427781 acaaagaaga tcaagacaag cttgagaagc ttaaaaacga aaatagcgat ctaaaaaaga 2427841 ctcagaaatc attaaaagct gagattaaag agcttcaaga aaatcaaaag cagctcaaag 2427901 aagatgcaaa aacggcaaag gctgaaaatg aaacacttcg acaagataaa acaaagcttg 2427961 aaaatcaatt aaaagagacg gaaagccaaa ccgccagctc tcatgaagac actggaagtt 2428021 cttcaaacaa tacgagtaaa agtgatgaaa ccaaaacagc tgacaaagca gaaggctgta 2428081 atatcaaagg aagcagaaac ggcatctacc acacgccagg cagtacatac tacgaccgga 2428141 caaccgatcc ggctgaaatg ttttgctcag ttgaagaagc tgaagccgcc ggttatcggg 2428201 cgccaaaacg ataaacaaaa agctccagaa tgtctggagc tttttctgtt tcacaacgac 2428261 gatttaatga ccttcttata ataaagaact gacagaaaac caaaaatgga gtagagcgca 2428321 gtatataaca ccatcaccat aatcataggc gcccatacct ctgatccgaa taagaaccag 2428381 ccggattgga cggcaaagta actgtggaag aggccgacaa cgagcggaat gccgaagttg 2428441 tacatttgtt tgatgcgtat cccctttatc aggtcgccct gcgtaaagcc gagttttctt 2428501 aaaattgtat agctcggttt ttcatcttca ctttcaccca tttgtttaaa ataaaggata 2428561 caacctgatg taatcaggaa cgttaaccct aagaagccga cgatgaacat caccatacca 2428621 aacagtgatt tttgcgcagc gcttgtatct agtcttgata aatgctcgtt tttcttgttc 2428681 acctgttgaa aaagctcatt tgctttttcc atttgatcgt catgtttcac attgacgccg 2428741 ataaatgtag attgcgccag ctgaatgcgg gggtctttat ccttgtccag ctgtttaaac 2428801 aggctgtcat ccacaatgac agcgggcatg cccccgcttg taaacgtgta ggacacaaga 2428861 aactcttctc ttaatccttt atattttaat ggctgcgtct cgtgcttgct ttttacttta 2428921 ataacaccag agtccttgaa aaccattatt ttttgcagca agtcggtgta tcctgagaaa 2428981 acggcttctc cagccgccac atcgactcct tttacatctt tgtcgctaac aacagcaagc 2429041 tgcatattgc cgggatcgcc ctgcatctct ttcggagttc catccataat atttgcaatg 2429101 tcaacatttg cttgcaggac aggtgttgcc ttttttacaa acgagatgtt gctttccctc 2429161 aatttgtttt caaataactt ggcatctttc tcattcatga atgaaaaatc agccgctaca 2429221 ttttgttcag cggtcttttc cgacgagtaa tacgagatgt aagcaagaga taacagcccg 2429281 atggcgagcg ctgaaacggt tgtaataatc gtcagcagca gcgcattcga tttcattctg 2429341 aacatgatcg aagacagtga cagaacctca gaaatattta agtagccgcc cttgcttttt 2429401 cgaatgatat tcgagataaa cgtaactgat cctttataaa acaaaaacgt cccgataatg 2429461 acgctcccca gaatgaagct catcgcaaca aacagttcat taatggtctt aaattttccg 2429521 ccaaacagct cagaagacac atagtatcct gtcaaaatca acacgatgcc taaagcgccg 2429581 atcagcattt ggaaaaatga tattttcttc actttgtctt cagtggagga cgttacttta 2429641 aacaaagata aaatactctg ttttttgata aacgtataat tcatgatcat gatcaaaagg 2429701 taaatgccgc agaacacaat gaccgtttgg accaaggcct gctcagaaaa atgcagtttc 2429761 gcatccgctt tgacatcgac aattttgaac agaatcatca agacaagctt cgatatcgaa 2429821 aacccggccg ctaccccgat cgctaatgaa ccgaaataca gcatgacatt ttctgcactt 2429881 aagatgcgaa aaattttatg cttcgtcatt ccaattaatt gaaacagccc gatttcttta 2429941 ctccgtctct taataaaaat cgtattggca tataaaatga agatcgccac tacagccaca 2430001 agcaaaatcg aagcggtttt aatagccgcg gctcccttga ttgaagcctt cacttcgtta 2430061 attgctggat catactgcag cgtgacaaag gcgaaataaa gcgccacgct aaagatgagc 2430121 gcaaacacat acaaatagta attccggaga ttctttttca aatttcgcag gatgagctga 2430181 ttaatgttca tgctgcaccc cgcctaacac gccttgcgtt ttcataatat cctggaaaaa 2430241 cgtttgcctg tcctggcccc ctttattcag ctgtgtatac atttgcccgt ccttaataaa 2430301 aatgactctg ccgcagtagc tggcagcgac gggatcatgg gtaaccataa taatcgtcgc 2430361 gttgcgtttt tgattgagct ggctcagctt atttaataga tcggaggccg atttcgaatc 2430421 gagcgcgccg gtcggttcat cagcgaaaat aatgctcggg tcatgaataa acgctcttcc 2430481 agcggatgtt ctctgcttct ggccgccgga aatttcattc gggtatttat cccgcaattc 2430541 atatattccc agttccttgg caacttcctc aaacttgcga ttggcttcct tttttgatag 2430601 tttcgtgatc gataaaggca gaaggatatt ctctttcact gtcaatgtgt ctaacaaatt 2430661 gtaatcctga aagataaagc ctaaatgctg ttttctaaat tcagccagct gcttttcctt 2430721 catagccgtc atgtcatttc cattaatatg aatggttccg tgactgacct gatcgattga 2430781 ggacagaacg ttgagcaaag tggtttttcc cgacccggaa gcacccataa tactgacgaa 2430841 ttcgcccttt tcaatgtgaa tatcgatgcc cttcagcact tcctgtttat tcagcttgtt 2430901 tccataactt tttcgaattt tattcgcttc taaaatcacc atttacgcag tctcctttat 2430961 attggataat ctcattataa aaaggaatgc cgggcttttc cttcgatacg gcgaacaaaa 2431021 aagaaaagca tgtgacattt tcgtcacacg cttatgacat gttcaaattg attccgtatt 2431081 ggaaaggtta atgtaaaaac tgttcccgca ccaaactccg actcaacatc aatatggatc 2431141 aataacggcg ccgctgcttt ttttgccaag tacagcccca tgccagttga cgcttgatca 2431201 tggtgatccg ttgtggatgt aaacccttta tcaaaaatac gcggtacatc ttttggatca 2431261 atgcccctgc cacaatcttt cacttggagc tgcgtctgtt cccctttttg aaagcttttg 2431321 atctcgattt cagaggcttc gctgtatttc accgcgtttg tcagcagctg cctgatgata 2431381 aacgccagcc attttgcatc gctcagcact tctttggcct cgagctgtat gtcaaaaccg 2431441 atcccttttt ggatacacca cgattgtaaa tctttgattt ctttaaagat caaaggctga 2431501 agctgaatga attctactga caggtcgttt tcaataaatg aaatgcgttt ttgatgaagc 2431561 tgctgatcaa gaagcaggtg aatacgcagc cattcatatg acagctggga tttcagtgct 2431621 ttttcttcca ttctatcaat gattaaatgc atcgctgtta atggagtttt gacctcatgg 2431681 atccatgcca tcagctcatc tttttcattt tccaatgcta agcgatgccg tgctgcggtc 2431741 tgcttcaagt gttctgtttg cccggcaatg cttctttcaa ccattgcttc aaacggcgtt 2431801 tccggttcat ttatggctgt cacatcgaga ttgttctccc atgttttcaa gcttttataa 2431861 aacgctgttt ctttccgata gcggaaccaa aggaatatga taaaaaacaa gatgcacaaa 2431921 tacaccatat aaagtacatt cccaaatgat atggaaggat cgacaaaagc aatgaacagc 2431981 atcaaagcct gctgaaacaa aaacgcggca atccagctcc gcctttcgat aaggaatgct 2432041 ttaatcatag aacttgtcct cttccttcgc gatgtagccc tggcccacct ttgtctcgat 2432101 atatgcacca agctgcaggg cgtccagttt ttttcgcagg cgattgacat tgacggtcag 2432161 cgtattatca ctaacaaaac gctcatcgtt ccacaagctt ctgatcagct cttcccggct 2432221 gacgatcttg tttttttgct ctattaattg ttttagaatg aacatttcat ttttggtcag 2432281 ttcaacagat cctttgtcat tgctgacgag gttctgctcc gcgtctacag cagcgccgca 2432341 ccacgtttta atcgtactcg gctccgtatt ataatggtgc acacgccgga acatcgcttg 2432401 gattttcgcg atcagcacat caaaatgaaa tggcttttga ataaagtcat ctgccccgag 2432461 ctgcatggac atcaccatat cagcaggatg atcccgggag gataaaaaga gaatcggaac 2432521 atttgaccgg gagcggatca gacggcacca atgaaagccg tcaaatttag gcagctgcac 2432581 atcaataatg acacaatcag gattaaccgc cgcaaattcc tgcagcacct gactgaaatc 2432641 ctgaatgccg tatacatcat aggaccatcc cgttaaacga tccttgattt catgaaacag 2432701 cgattcatca tcttcaatca gcaaaagttt aaacaatcga ctcaccgcac tttttccttt 2432761 tttatcaagt gtatagcaaa acgccagcat gcgctataga aaaagccggc tgtctcagcc 2432821 ggctcgttcg cattataatt ctcttctcaa cgctgtcagc acgttggttt tggtagcttt 2432881 tctcgccggg ttcattccgg aaatgactgc gacccctccg caaatcacaa cggcaatgat 2432941 cacaaggctc gccgggatgt aggagaatgt gtaattcaaa tcgcccgcat cgccaccgct 2433001 tgtggccgca agaatcatcg gaacggccag gttgacaagg tagctcacgc cgtaagaaat 2433061 gataatccca atcacacagc ctaaaattcc gatatacgcg ctttccatca agaacattcg 2433121 gcgaatgatt gacgggctcg ccccaatcgc tttcataatg ccgatctctt gcgttctctc 2433181 tgtcaccgcc atcgtcatcg tgttaaaaat gccgatcgct gaaatgataa ctgcgataca 2433241 tccgacaaag atcagtccga ttttgaagac catgaagaag gtattggctc cctcaagttc 2433301 agtagtcact gatgtgacat agtacccgtc atctgttaga tcatttgtca gctgttccac 2433361 attctcaaac ttatcagcaa aaacaccaat gttcgtttca acatttccgc ctttgaaatc 2433421 taagaattcc gaaaaatctt ttttgaattg atcactgata aaaatatttg agtcctccat 2433481 ccagtcttga gatggttttt ttgtaatacc gacaatttta aagtcatatg tttttgtttt 2433541 tgtaacatcc cctgttttag aatctgtctt cgatacactt agttcaattg ttttatttag 2433601 aatatctttc gtatagccct ttggttcttt tatatcttct ggatttcctt ttgcttcctc 2433661 gatttttttg ttatattctt ccgattcttt tttcgttaat aatctctttg cgaagtcgta 2433721 tcctactacg atttcatttt ccgactttgc gactcttccc ttttccaatt ccatattggc 2433781 ctttaattca tcattcatat tagtaaaaat gagatttgag ctttcatttg tacgattgcc 2433841 taaagtagct ttgtttggtt catacacttg cgttctttct acaactgacc ttacgtgatc 2433901 atacttctct aaatcagctt ttttaatcgg cttgtctcct tccttgccca ttacgctgac 2433961 tttcgttaca atctgctggc tcattgtcat atctgtaatc gtcttttgaa tcccaaatcc 2434021 aacggacgac aacacaacca aaaacgcaca cgccattgtt gtcgccagaa tcgtcataaa 2434081 gacgcgaagc ctgtttttct tcatatttct tctgataaaa tgaacctgat ccttaaacct 2434141 caacggtaat tcctcctttt agcacaccat catgaagctg aaattttgaa tgtccgatag 2434201 aagcgacttc atcatcgtga gtaatgatca caaatgtaat gccacgctca cgattcagct 2434261 gctggatcaa ttccagcact tcatgttccg tttctgaatc aaggcttccc gtcggctcat 2434321 ccgctaagat aatcgaagga tttaaaatca atgctcgagc aatactgaca cgctgctgct 2434381 ggccgcctga cagttcattc ggataatgag cggcgtggtt ttccagaccg acgcgtttca 2434441 gcatgtcctg caccttttgc ttccgctcag atggcttgat tccttttaac gccagcggca 2434501 tttccacatt ctcatacgtc gttaaacccg ggatgagctg aaagctctga aaaataaacc 2434561 cgaaatggtc aagccgaaat tgcgcccatt ccttttcatt aaaccccgta acatcagtgc 2434621 cattaatgac aatccgccct tttgtcggcg atatgtagcc ggaaattaaa ttcaaaagcg 2434681 ttgatttccc tgagccgctt cgtccgacaa tgcaggcgat ttcccctttc gccacgctca 2434741 atgaaacatc cttcaatact ggaacttcat tctcacggcc cttttttccg atcgtgaaag 2434801 aatggtcgat atgctgaaca tcaatcatat gttctctctc ccttacaaaa gtttcatttt 2434861 tttataaatc gcaaaataac taatcaagaa accgattacc gcacctgtac ccatgccaat 2434921 gagataaccg gcaaagctct cgcttgcagt aaatccaaaa tagccgaagc ccatgattcc 2434981 tatgataata acgatgatct gcaccgggcg gttaagcggc ttccataaga agaaatatcc 2435041 gtttctttca ttagacattt taacaaagct aatatagccg atgatgtaaa aaatgatagt 2435101 catgatagcc ggaatgacta aataatatgg tgaattctca gcccatttcg agtctacata 2435161 aattatcgga atgaaatact gcacccattt aggtactgga ccatggataa aatctattga 2435221 tccgccaaaa aggatctcga ggttgatcac aggcaggctg atgagtaaaa acggcgaaat 2435281 ggccacggta aatgagacta gaagctgtgc gaaactattg cctgtcaaag ctcctccggc 2435341 cataaccaaa gaataagcca gcatgctaac aataatcatt cccaagctgt aattgtgaaa 2435401 ataaacggcc tgatctggct tcaaaagcat gatcagcaaa acagacaaaa cataacctat 2435461 gagctgcggc accacaatca ccattccgcc ggtaaggaac ttcgcatgaa atatctgccc 2435521 tcgtgtatat ggaaggctta atgtaaaatc aaagaagctc ttgctacgtt caatcccaag 2435581 ctggctgacc gccaaaacga ctccccaaat ccaaaacaat gagataaatg agctatttaa 2435641 ataatcaacg ctgaatacgc aggggccgac ccaattttct tttccagtga cacagccttg 2435701 atagatgaga tacatattta aaattgataa tggattacct aatataaaaa ccaaaatggt 2435761 gataactaag gcgactttat tctgccgcca ctctttgtaa agcagtccgg aatccggcaa 2435821 ctcacttccc tccaaaccta aggcatttct tacacttttg ttttcttata aatagagaag 2435881 tagctcacaa agaatccagc cactgctcca atgatcatac ccaaaatata accaataatg 2435941 gaatgtccgg tatagtatcc aaataaacca aatccaagga tgccgaaagc cataaccaga 2436001 atttgcaccg ggcgatctaa tctgttccat aagaaaaagt gtccgttccg ttcacttgga 2436061 agcttcttga agcttataaa gccaatcaag taaaatagca tgctcattac ggctggaatc 2436121 aataaaagat atttactgtt aatcagccat tcatttacaa cgtaactaat cggtactagg 2436181 ttcgataaat tgcttgccag agagaaataa ctctcagggg aagggaatat ttcccatata 2436241 ttcgcaccaa aaacaacttc taggtttcca accggcaatg caataattaa atacggcaat 2436301 atagctgctg aaaacgccgt taacagttgg gcaaaagcat ttccagttaa cgctccggcg 2436361 gccatcacca gtgaaaaagc cataaaactt atcacgatta ctccaatgct gctgtgctca 2436421 aaaaagtaga cgtgttcagg gttatagaca agaatcagca gccatgcaag taaaaagcca 2436481 atcaattgtg acagcacaat cacaaaaccg cctaaccaaa attttgtctg aaaaatttgg 2436541 cttctgttat acgggaggct taatataaaa tccatcgtgc ctttcgaacg ctccattccg 2436601 aggaagcaga ccgccaaaat gacacccggc acccagttga tatctatcag attgcttatg 2436661 gaataattca caataaaatc acaatattgc gggtcttggc gatcaagaca cccttgataa 2436721 gacaaatacg tattaacgat agaaagcgga tttgccaata ctaaaaacgc gatacttaac 2436781 aaaatcacca cttgattctg cttccactct cgatagagga gacctcggtc taccatctcc 2436841 gcttccctcc aaacttcgca atgaacactt cttccaggtt gacaggaagc tcattccaca 2436901 cttttggctt cagctctctc aaaaagctct ttttctcctc atcgcttttc ggaatcagca 2436961 ctgtgtaaaa cacgccggcc tgatcgagca tcggaatgtt ttgctctctg atggccaaat 2437021 tgacatctgt atcgaaggcc atttgaattt taatgtattc ttcttttaac tcatcaagat 2437081 ccatgacgtt ggtcaggctg ttatcttcaa gaaaaccaat tcggttgcac atccgctcta 2437141 tgtcttcaag ccggtgggac gtaatcagga tgctcgtatc acgctctgcc acttcatcga 2437201 ccatcagctg cagcacatca tgccttgtca ccgcatcaat accatccgtc ggctcatcaa 2437261 ggaggatcag cgccggtctc gccgcaaacg acagaacgag cgatagctgc ttttttaagc 2437321 ctgtcgacag ctcacggtat tttttcgttt ccggaatttc gtatctgttc atcagctcat 2437381 tcgcgtacgt gacatcaaat ttcggatata ttcttctcaa aatatcgact aactgcttgt 2437441 atgtatactt atcgtaaaac ggattttgaa caggcatgta gatgatattt tgtttgactt 2437501 tcgggtgctt tttgatttct acgccgtcaa ataaaatcgt tccgctgtca gcgaaaatga 2437561 tttgctggat taagcgaagc atcgtcgttt tgcccgatcc attgcgtcca agcaatccaa 2437621 agatttctcc tttttcgatt gttaatgaaa catcttttaa tacttgattg ccgtcaatcg 2437681 cttttgacag ctgccgcagt tcaatcattt tttttgcctc ccttcacatc agcgctgatt 2437741 tcctttatcc attcgtgcag tttttccagc tcaacccctg catagtgtgc atcgatgatg 2437801 agctgtttga gttgctcttt aatcatcgtc atcttccctt caaccagtgt cgtttttgca 2437861 ttctccgata tataggtccc tctgccccgc agcgtttcaa taatcccctc tcgctcaagt 2437921 tctttatacg ctttgctgac agtgttcgga ttcgcaataa tgatcgttgc caattctctg 2437981 acagaaggaa gcttatcacc aggcttcatg atccctttca aacaaagctc tttcatttgc 2438041 tgaataattt gttcgtaaat gggtgttgag cttcttggat cgatttgaat catttacttc 2438101 cctactttct atacgatctg aaccttttat agataaaaat gatcaattat acttttttgc 2438161 cattcaaaac cgatcatcac aagaacaaga aaaaaagaac aagcgatcac agatgccgca 2438221 atcagcattg gcacgttacg tttgtttcgt tttttatgtt tcataactgc ctcccttaat 2438281 gtcaatatat aaatgatttt atattagtgt ctatagtgta ttacttcaat tagtacactt 2438341 aatacaataa atactttgac tcacaaagtc aatccttttt ttacaaaaaa acggaccctt 2438401 ttaaaagggt ccgttttcct acacatcaag agggtgctgc aggatcatat tattttgcaa 2438461 agattgaagc tgaagtctca ttctgtacag ctgttctctc tgctgatcat ttgacgacag 2438521 ccatagttta ttcaaggcat ttaccgcatc ttctagctgc atttgtgcat cactatattc 2438581 ttgatcgtta taatgctctt gtttagaagc gattttcagc tgttcttcag cataatcata 2438641 ggcctgcata cattgctgga gatgttcatc tactgattgt cttgttgcca cagtaacccc 2438701 tcctcttggt aatggaaatc atccatcatt catattgtag cctcatctga ctttattcaa 2438761 taaagtaatt tatggtcgat attcatttgt tctcttgtga aatgcgtgct acaattttag 2438821 gatgcaatcg tacgcaagga ggcacatgaa ttgtgatgca gaacaatcct tttccttatt 2438881 caaatacgga aaaacgctat catacattga attatcatct cagagaacat ttcggccata 2438941 aggtgtttaa agtagcgctt gacggcggtt ttgactgtcc aaatcgggat ggcaccgtag 2439001 cccacggagg ctgtacgttt tgcagcgcag caggctccgg agattttgct ggaaaccgga 2439061 ccgatgattt aattacgcaa ttccatgaca tcaaaaaccg catgcacgaa aaatggaagg 2439121 acggcaagta catcgcttat tttcaggctt tcacaaacac tcacgccccg gttgaggtgc 2439181 ttcgtgagaa attcgaatcc gtcctcgcct tagatgatgt ggtcggcatt tcgatcgcca 2439241 cacgcccgga ctgtctgcct gatgatgtcg ttgattactt ggcagagctg aatgaacgta 2439301 cgtatttgtg ggtggagctt gggcttcaaa cagttcatga acggactgca cttttgatca 2439361 accgcgcaca tgattttaac tgctatgtgg aaggcgtcaa taaattaaga aaacacggca 2439421 tacgtgtctg ctcgcatatt atcaacgggc tgcctttgga agaccgggac atgatgatgg 2439481 aaacggcaaa ggccgtcgca gatttggatg tccagggcat taaaatccat ctgcttcacc 2439541 tactgaaagg cacgccgatg gtcaaacaat atgaaaaggg caagctggaa tttctttctc 2439601 aagatgatta tgtgcagctc gtctgcgatc agcttgagat cattccgcct gaaatgatcg 2439661 tccaccgcat tacaggtgac ggaccgattg agttgatgat cgggccaatg tggagcgtca 2439721 acaaatggga agtgcttggc gccattaata aagagctaga aaatcgaggc agctatcaag 2439781 gaaagttctt tcaacggctt gaggaggaat cagcgctatg attttgaaga aaattcttcc 2439841 ttacagcaaa gaactgctga aaatggccgc gggagaggga gatattgtcg tagatgcgac 2439901 aatgggcaac ggacatgata cacagttttt agcggagctt gtcggtgaaa acggccatgt 2439961 atacgcattc gacatccaag aatcagccgt ggccaataca aaggaacggc tcggtgacat 2440021 gtatcaagcg cgaacaacgt tatttcacaa aagccatgat aaaatcgctg aatccctccc 2440081 gcctgaaaca catggcaaag tggcggccgc ggtatttaac ctcggctatt tgccgggcgg 2440141 ggacaaatca attacgacaa acggcagttc tacgatcaaa gccattgaac agcttctcag 2440201 catcatgaaa gacgaaggtc tgattgttct cgtcgtctat catggccacc cggaaggcaa 2440261 agctgaaaaa aacgacgtgc tcgagttttg ccgggacttg gaccagcaaa cagcccgtgt 2440321 attaacatac gggtttatca atcagcaaaa tgacccgcca tttattgtcg ccatcgaaaa 2440381 aaaagctcag atcagcaaat gatttgagct tttttctttg aatttttcat ccaggacatt 2440441 ttttgaaatt tccggtaggc tctgccgttg atataaaaga aaagggaggt ttttccgctg 2440501 gctttgatca gcttctttgc gagccggacc tgcttcgtct tactttacca tttttcaaat 2440561 tatatttgaa agcaataacc atcgttaacc cggacgtcat acagttcggg tttcgatttt 2440621 tccataaaac gttcacatat agcatgaaac gtatgacttt tatcttatca caaaactata 2440681 aacagcctct gcaaaaacac atacctattc tttcctgttc tctattttct atgagcacac 2440741 acaaaaagag cccactggga gctctttttg tcagctgata tttcgttcgc tggcagcagc 2440801 cgcatttttt ttatgaaacc cttttccata gtacacagcc agcaagatga gaaaccatat 2440861 cggcccgata atcacggcta ctcttgtatc agggctgtaa gccataagaa tgacgacgaa 2440921 tgctagaaat gccaatgaca cataagacgt aaacggaaat aaaggcattt tgtactttaa 2440981 ttgtttcttt tcttccggct tcaaactttt cctgtatttt atttgagaaa gcaaaatgat 2441041 tgcccacgtc caaatcgctc cgaacgtcgc aatacttgta acccaagtaa ataccttcgc 2441101 agggacaaca tagtttaaca gcactccgac taataaagcg cccgctgaag ccagaacagc 2441161 tttacccggg atgccgcctt tcgtcagctg accatatgct tgtggcgcct ctttctgttc 2441221 cgccaagtta aacagcatcc gccctgtgct gaaaatacca ctgttgcatg aagacagcgc 2441281 ggctgtcaac acgacaaagt taatgatacc tgcggccgat ggaatgccca ctttttgaaa 2441341 tgtgagaaca aatggacttc cttgagagcc aatttcctgc cacggataaa tagacataat 2441401 gacaaataaa gcgcctacat aaaaaatcaa aatccgccaa aatactgtat cgattgcttt 2441461 ggctaacgat ttttgcgggt tttttacttc gccagccgtc accccgatca tttcaatccc 2441521 taaataggcg aacatgacca tttgaagaga caataaaacc ccttttaatc catgagggaa 2441581 aaatcctccg ttgttccaca aattgctgat tccggttgca atgcccccat tgccgactcc 2441641 tgcaataatc atcaataaac cgacagcaat catggataag attgcaacaa ttttaatcaa 2441701 tgcgaaccaa aattccagct cgccgtaagc tttgacagcc aggaaattaa cacccgtcat 2441761 aatgaccagt gccgataacg cccaaatcca gtttggcacg tccggaaacc agaaccccat 2441821 atagatgccg acagcagtga tttcggccat acaggtgaca acccataaaa accagtagtt 2441881 ccaacctgtt aaatagcctg caagcggtcc caaataatca cgcgcatacc tgctgaagga 2441941 gcctgcgacc ggtttttgaa tggccatttc cccaagcgct ctcataataa aaaacatgac 2442001 caggccgctt gcggcatacg ctaccaaaat accaggccct gctaattgaa tagctgatgc 2442061 ggagccgagg aacaacccta ctcctatagc agctcctaaa gacattaaag aaatatgcct 2442121 ttcttcgagt ccgcggtgca gctcttgttt ttgtttttgc atgcttcttc tcccctagaa 2442181 aaaaatatca ttatatcatt tttctgaata ttccgtacgg attgggtaaa tcaatgatga 2442241 tggagaaata aaaggataac aacaaggctt tcgactactc gaaagccttg ttgtctgtta 2442301 cacaaagatg acttctttag gctgatggct cagctcttca ggcatatacc gtttttcaat 2442361 attgatgctg tgccagatca taaagattag cacagtccaa attttacggc tgttatcagc 2442421 cttgtccgca caatggtctt caagaagctg aaggacataa tccttatgga tataagcatc 2442481 cgtttggctt tcttgaataa tattccgcac ccattcgttc atttcgtttt tcagccaatg 2442541 acggatcggt acagggaaac caagcttttt gcggtttaat acgtgctcag gcacaattcc 2442601 ttcagcggct ttgcgaagaa gatacttcgt cgtgccgttc ttcgttttca gctcatcagg 2442661 aatttttgaa gcgacgtcga atacgacttt atccaagaac ggcacacgca gttccaaaga 2442721 attcgccatc gtcattttat ccgcctttaa caaaatgtcg ccgcgcatcc aagtgtggat 2442781 atcgacatac tgcattttgt tgatatcgct gtacgagctg ctttctgtaa agtaagtctt 2442841 cgtcacatcg cgatatgaaa ggttcggatt ataatgcttc aacagctgct ttttgacaga 2442901 ctcttcaaag attttcgcgt taccgatata acgatcctga agcggagtgc agccgcgctc 2442961 aagcaggctc ttccctctca taccttcagg cataacggca gcaacgtgca gaagcatctt 2443021 tttcaagccg gacggaatcc gttcaaacgg tttaagcgaa agcggttcac ggtaaatgtt 2443081 atatccgccg aagagctcat ccgctccttc acctgataaa gcaaccgtaa catgtttttt 2443141 tgcttctttt gcaacaaagt acaacggaat cgctgccgga tcagcaagcg ggtcatcaaa 2443201 atgccatacg atcttcggaa gctcattcat gtattcctca ggcgaaatga ctttgctgat 2443261 attttcaatg cccagcgccg ctgccgtttc tttcgctaca tcaacctcac tgaagccctg 2443321 ctgttcaaag ccgacagaga atgtttttaa gcttggatga aattccttcg caacagacac 2443381 aataaaggaa gaatcaatcc cgccagacag gaacgaaccg acaggaacgt cacttctcat 2443441 atgaacgttt acagagtcat agatcgcgtc tcggacttct ttcacaagct tgtcttcttc 2443501 agtctgaacc ggcttgaagt tcgctttgaa atacgttttg aatgtgatat cgccgtccgg 2443561 gcggattgtg aattgtgaac ccggctctac ttttttcaca tgggcatcaa gcgtgcttgg 2443621 ttcaggaaca aattggaaag acatgtactg ctgcaatgcc tctttatcta tttcaatatc 2443681 attctgagca accattaaac tttttctctc tgaggcaaaa taaacctgat cattgatcgt 2443741 tgtgtagtac aacggtttaa tgccgaatgg atctcttgcc ccataaagca catgatcgtt 2443801 tttattccaa atcagaaagg caaacatacc gcgcagtttg gacgccgctt cttctttata 2443861 gtgacggtaa gtcgcaagaa gaacctctgt gtccgaatcc gtgttgaatg tgtacccctt 2443921 tgcttcaagt tcttctctca gttcgatata gttatagatt tctccgttaa agataatcca 2443981 atatgtttca tcttcatatg ataaaggctg tccaccattt tctacatcaa taatgctgag 2444041 ccgtctgaat ccgaagccga cgtgctcatc atggaaatat ccatcactgt caggaccgcg 2444101 gtgaacgatc atttggttca tttgtttgat tagttcttct tgatcagcgg tttgagctaa 2444161 cggatgcttg ttaaaaaccc cgacaaatcc acacatagta ttgcctccat aattaaaatt 2444221 gtcatcattg aacccctatt tatagacgct gtgaatagta tttggtttca cagttatgta 2444281 aaaaaataaa catgaataca acgataaaaa agggaaagcc gcttaaccag taagcggcta 2444341 taaaattatt ctcctaacgc ttctttacgc agctgctccg ctttgtctgt gcgctcccat 2444401 ggaaggtcaa catcgtgacg tccaaagtgg ccgtacgcag cagtttgttt atagatcgga 2444461 cggcgcaaat caagcatttt gataatgccg gcaggtcgta aatcaaagtt attgcgaaca 2444521 acttcaatca gtttttcctc agaagctttt cctgaaccga atgtgttgat tgagattgac 2444581 acaggctgtg caacaccgat cgcgtaagca agctgtactt cgcaagaatc agcaagctca 2444641 gccgcaacga tgtttttcgc aacgtatctt gccgcataag ctgcagaacg gtctaccttc 2444701 gtcgcgtcct tacctgagaa cgcgcctccg ccgtggcgtg catagccgcc gtacgtatca 2444761 acgatgattt tgcgtcctgt aagtcccgca tccccttgag ggcctccgat tacgaaacgt 2444821 cctgtagggt tgatgaaata ttttgtttct tcatcaatca gctcttcagg aacaaccgga 2444881 ttgattacat gttctttaat gttgcgctga atttgctcaa gtgtaatttc agggtgatgc 2444941 tgagttgaaa taacaatcgc gtcaatgcgg actggtttgt tattttcatc gtactcaacc 2445001 gttacctgtg ttttgccgtc agggcgaagg tacggaagaa tatcttcttt acggacttca 2445061 cttaggcggc gggctaattt atgggcaagt gaaattggaa gaggcataag ctctttcgtt 2445121 tcgttgcacg cataaccgaa cattaatcct tggtcacccg caccaatcgc ttcaatttct 2445181 tcgtcgctca ttgtgccttc acgggcttca agcgcttggt ctacgcccat cgcgatatca 2445241 gcagactgct catcaattga tgttaaaacc gcacaagttt ccgcatcaaa tccgtatttt 2445301 gcacgtgtgt atccgatttc tttaatggtt tggcgaaccg ttttcggaat gtcaacatac 2445361 gtagaagttg tgatctctcc gcttacaaga accaaacctg ttgtcacaga tgtttcacaa 2445421 gcaacacgcg cgttagggtc tttctttaaa atttcatcta aaatgctgtc agaaatctgg 2445481 tcacagattt tatccggatg cccctccgta acagattctg atgtaaataa acgacgattt 2445541 ttactcatga tttgcttcct cctgcacaag gcctcccgaa agaccttgta tatatgatac 2445601 ggaactcgct ccctcttata caatgtacag ttatattaga gaatgttaat tggcatattt 2445661 atgaaataaa aaaacctttt ccatcgagga aagggtttgg tctttgtgcc tttcactctt 2445721 atcgctcaag gaatcataca accttgcaac aggttagcac cttggttgtc tcactcagtt 2445781 gaacataata aataacagag aaaccggttg ctgggcttca tagggcctgt ccctccgcca 2445841 gctcgggata agagtatccg ctcaatgaaa tatcttatcg taaaagggtt tgcaatgtca 2445901 atatgattca gaagaaatag gcacctatat tgagggaaaa caatggaaat gcacacacaa 2445961 aaaacaataa atagtataga ctatttgaaa atatatgtta tactaattca caattagcaa 2446021 aacacaaaaa acgataaagg aaggtttcat atgaactcag ttgatttgac cgctgattta 2446081 caagccttat taacatgtcc aaatgtgcgt cataatttat cagcagcaca gctaacagaa 2446141 aaagtcctct cccgaaacga aggcatttta acatccacag gtgctgttcg cgcgacaaca 2446201 ggcgcttaca caggacgctc acctaaagat aaattcatcg tggaggaaga aagcacgaaa 2446261 aataagatcg attggggccc ggtgaatcag ccgatttcag aagaagcgtt tgagcggctg 2446321 tacacgaaag ttgtcagcta tttaaaggag cgagatgaac tgtttgtttt cgaaggattt 2446381 gccggagcag acgagaaata caggctgccg atcactgtcg taaatgagtt cgcatggcac 2446441 aatttatttg cgcggcagct gtttatccgt ccggaaggaa atgataagaa aacagttgag 2446501 cagccgttca ccattctttc tgctccgcat ttcaaagcgg atccaaaaac agacggcact 2446561 cattccgaaa cgtttattat tgtctctttc gaaaagcgga caattttaat cggcggaact 2446621 gagtatgccg gtgaaatgaa gaagtccatt ttctccatta tgaatttcct gctgcctgaa 2446681 agagatattt tatctatgca ctgctccgcc aatgtcggtg aaaaaggcga tgtcgccctt 2446741 ttcttcggac tgtcaggaac aggaaagacc accctgtcgg cagatgctga ccgcaagctg 2446801 atcggtgacg atgaacatgg ctggtctgat acaggcgtct ttaatattga aggcggatgc 2446861 tacgctaagt gtattcattt aagcgaggaa aaggagccgc aaatctttaa cgcgatccgc 2446921 ttcgggtctg ttctcgaaaa tgtcgttgtg gatgaagata cacgcgaagc caattatgat 2446981 gattccttct atactgaaaa cacgcgggca gcttacccga ttcatatgat taataacatc 2447041 gtgactccaa gcatggccgg ccatccgtca gccattgtat ttttgacggc tgatgccttc 2447101 ggagtcctgc cgccgatcag caaactaacg aaggagcagg cgatgtacca ttttttgagc 2447161 ggttacacga gtaagcttgc cggaaccgaa cgtggtgtca cgtctcctga aacgacgttt 2447221 tctacatgct tcggctcacc gttcctgccg cttcctgctc acgtctatgc tgaaatgctc 2447281 ggcaaaaaga tcgatgaaca cggcgcagac gttttcttag tcaataccgg atggaccggg 2447341 ggcggctacg gcacaggcga acgaatgaag ctttcttaca ctagagcaat ggtcaaagca 2447401 gcgattgaag gcaaattaga ggatgctgaa atgataactg acgatatttt cggcctgcac 2447461 attccggccc atgttcctgg cgttcctgat catatccttc agcctgaaaa cacgtggacc 2447521 aacaaggaag aatacaaaga aaaagcagtc taccttgcaa atgaattcaa agagaacttt 2447581 aaaaagttcg cacataccga tgccatcgcc caggcaggcg gccctctcgt ataaaaaaca 2447641 aaagccaaga gcaattatgc tcttggcttg ttttaattga cggaatgcaa agaagtcagc 2447701 ttgtatgtaa tgatggtccg gccttcttcc cattgaagct tctgcacttc agctgtgcct 2447761 gacttttcgc caaactttgt tttgcgtaca tccattggaa tctccatcgg atatactcgg 2447821 tatccgtcct tctctaacgt gaatatattt tcatctatgc gaacttcttt tccttttgtc 2447881 acaatcagtg tattaaattc aacaggcatt cccaaagtga aatccccttt cgttctcttt 2447941 tttctttatc ataacatatt tcactgtcag cggtttttca tccattgtgt gagctgccgc 2448001 acgatacgcc ggttttcttt tggcgggaaa taatgtgtga atgtactgta gtaccatgtt 2448061 tccaccggct tatgcagttg ttttagcttc tcttctaata aataggaatg ctgaatcgaa 2448121 acattttggt ctttttctcc atggattaac agcacgggag cctgaatttt gtttacttgg 2448181 tcaaacggtg tcctccattg atattcctca ggcacctttt tcggtgttcc gccgatgact 2448241 cttttcatca ttcgccgcaa atcctgccgc tcctcgtatg taagaatcat atcactgacg 2448301 cctccccagg aaacaaatga agctgcctgc ccgcccattt cgatcgcagt gagcattccc 2448361 ataattccgc cgcgggaaaa accgaagata tggattctat ccttcttgac atttgggtgc 2448421 tgctgaagca ggcgaaaagc agaaaatgca tcctccctgt cttctccggc aaaatcctca 2448481 ttgccttctc ctccttgatt gcctctgtaa aaaggagcaa acaccacaaa cccttgggat 2448541 gcaaactgga taatccggcc cggccgaacc atgcccacgc ttttaatccc gccgcgcaaa 2448601 tataaaaatc cgtcatattg tcccggttcc gccggctcag ccagaagccc cttaacccgt 2448661 aatccatttg acagatagca gatcgtatac aaacgcacat gctggcttgg cgacggaaat 2448721 cttcttttct ctacaatcaa aacagccgcc tccttttttc tatatgcttt ccttactcca 2448781 aaattacatc cggagaacct ggttaggcat tcacacattt ttatacccat catacgatat 2448841 gtaaagcaaa aaaggatatt aacttgatgc gaaataagga ggttgtctat gtgaacagat 2448901 ggttaaggct gggcttcgcc tgtgtcggca gtatctttct gatgttcgcc ctggcggctt 2448961 gcaagcagga agaaacgctc accaaagtca aagtagctga agtgacccat tcaatttttt 2449021 acgcaccttt atatgttgct gagtctaaag gtttttttaa ggaagaaggg cttgatgtcg 2449081 atgtgaatac gacctggggc ggagataaaa cgatgacatc gcttctttcc aacggctccg 2449141 acatcgcgct tgtcgggtca gaaacatcta tttatgtcga agcgcaaggg gctaaagatc 2449201 ccgtcattaa tttcgcccag ctgactcaga cagacggaac gtttcttgtc gcgagagaag 2449261 atgttgaaca cttcgactgg gatcagctga aaggaaaaac gtttctcggt cagcgaaaag 2449321 gcggcatgcc gcaaatggtc ggcgagtatg tactgaacaa acataagatt gacccgcata 2449381 aggatataga cctcatccag aacatagact tcgccaatat tgccaatgcg tttgcttctg 2449441 gaaccggtga gtatgtacag ctctttgaac cgcaggcttc tctctttgag aaaaaaggca 2449501 tcggccatat cgtggcttca ttcggagaag aatcaggaga ggttccttat acgactttta 2449561 tggcgaaaca aagctatttg aagaaaaatg aagacacagc cgtcaagttt acaaaagcca 2449621 tttataaggc gcagcagtgg gttgaaaatc attctgcgaa ggacatcaca gatgccatta 2449681 aagatgaatt tgatgatacc gacccagacg tcatcgaaac atccattgaa cgctataaaa 2449741 aacagcattc atattcacca gaccctctgc ttaacgaaaa agaatgggag cttctccaaa 2449801 ccattatgga taaatcggga gaactgccga agcacattcc atacaatcag cttgtaaata 2449861 aagaaattgc tgaaaaagtc acctcggaga aataggaggc gccatctatg tctttcttac 2449921 atgtcgacca tgtaacccat acttattttt ctattaaaga aaaaacaacg gctgtgcggg 2449981 atattcattt cgatgccgaa aaaggcgatt tcatctcatt tctcggccca agcggctgcg 2450041 gaaaaacaac attgctttcc attattgccg gtttgattga gccatcagaa ggcagagttc 2450101 tgattgaagg ccgtgagccg aatcaaaaag aacataatat tggctatatg cttcagcagg 2450161 attacttatt tccctggaaa tctatcgagg aaaatgtgct tctcggttta aaaatcgccg 2450221 acacgctgac agaagaaagc aaagccgctg cactcggtct attgccggag ttcggcctca 2450281 tagatgtgga gaaaaaatat ccgaaagaac tgtcaggcgg gatgcgccag cgggctgcgc 2450341 ttgcaagaac acttgcgcct aaccctagtc tgcttttgct ggatgagcca ttttccgcgc 2450401 ttgattttca gacaaagctg tctttggaaa acctggtatt ccgcacatta aaggaatatc 2450461 aaaaaacagc agtgcttgtc actcatgata taggggaagc gatagcgatg agcgatacga 2450521 tctttttatt ttcaaatcag ccgggcacca tccatcagat ttttaccatt cctaaggaat 2450581 tggccgcgat gttgcctttt gacgcccgtc aggaaccttc cttccagaca ctgtttcaaa 2450641 cgatatggaa ggagctgaat tctcttgaga aacagcaaag aaaccattga tctgcttcac 2450701 gagcagtatc aattcaaaca gaaaaaggaa aagtggaagg tccattcctt tcagcttgcc 2450761 atatttattc tctttttctc gggctgggaa atctccagca ggcagggctg gatcgatccg 2450821 ctgatcttca gctctccatc agctgtgtgg cgattattgc tggagaaact tggtgacggt 2450881 tctttactgt cacacatcgg cgtcacttta tttgaaacgg tgcttggctt tttgctcggg 2450941 acgtttatgg gcacgtgcct agccgctttg ttatggtggt ctaaccgact tgccagaatt 2451001 ttagatccgt atcttgtgat tttgaacgca atgccgaaag tggccctggg cccgatcctg 2451061 attgtcgcgc tcggtcccag ttttatcagc atcattgcga tgggagccat catcagcgtc 2451121 attatcacaa ccatcgttgt ctacaccgcc ttccaagagg tcgacgaaaa ctatacgaaa 2451181 gtcatgaaaa cattcggcgc aaaaaagtgg gttattttta aagaagtcat actgcctgca 2451241 tcctcccccg cgattatttc aacactaaaa gtgaacgtcg gtttatcatg ggttggcgtt 2451301 attgtagggg aattcctcgt ttcgaaggtc ggattaggat atatgattat ttacggattc 2451361 caagtcttca attttacact cgtcttctta agcctgctga tcatcgccat cttcgccact 2451421 ctgatgtatc agggcgtcga gctgctggaa aagaaatgga cgaaggggag gacataaaaa 2451481 acccggcaca tgtgccgggt tttttattca atccatccag attctttcag ttttttcaag 2451541 ctgatcggaa gaacggaatc cttcataata aagctgaatt ttttattgcg ggaaaggttc 2451601 tccggcagct cgtgaaacaa aaccgggcct ttcgtttcaa agtaatcagc ctgcttttca 2451661 agcttttcta tatctgcaaa atatatattt tttacaatca ctttttcttt tccgagaact 2451721 ttatactgtc cgagatactt gaggcttttg actctcgcgc ccgtctcttc ctttacttcc 2451781 cggagcgcag cctcttctgc gcactccatc ggctctactt tcccgcctgg aaactcatag 2451841 cctctgtcct catgttctgt taaaagccat ttgccgccaa aacggcaaat cacccagaca 2451901 tgcttcgggc tgtccgagaa aggctgatcg tcaaaggaaa gctgaacagt attctgataa 2451961 taatctttaa actcgtacat gtttatccct caaatccgtt cctagctatc ttccatacat 2452021 cataccacag ttacgtttct tcggaagcct tttatcaaaa aataagggaa acccagcacg 2452081 ccgtcaggtt ctgcatgcag actagctcgt acagtttttt tgcgatactt ttgccggaaa 2452141 gtgcgaccga cgctctgggc tttattatga cccgcgaaca gggaaaagtt acggtttgcg 2452201 cttaaattta ttttttaacg tttctaaaag atcgacaagc atctgaggaa ccggtatgcc 2452261 aagagagctg gctgtcacaa caatttgcac agattcataa agaatataaa acataatagc 2452321 caagtcacga attgatccct gtgtattcag cagctgatca aaaaagtggc atacagagat 2452381 cagagccagc gtgactaatt ttttgacaag ccgggcaaat acctttttaa atgacagttt 2452441 gtgaataatg gtttccttca aagtcgtact gataaattca attgccataa gagagagcaa 2452501 aatcagaaat gaatactgaa aacctccaaa gaaaaaaccc gctgctgaaa cgctgactgc 2452561 taaaaacgaa aagatgccaa agtctctatc catttatccc aacatccttt cacagaaacg 2452621 gccttacgat attctatggt aaacaagccg aacggattgg atttttcaga aaaatggact 2452681 ggttgtcgcc tatttttcag atacaaaaag aaaagccgga cgtctttttt aagacatccg 2452741 gccgttctat ttttgaactt aacctaggta agcttttagc atccagttat gtttttcaat 2452801 attttgatgg atcgcaagaa gcatgtcccc tgttgtttcg tcaccgactt catcagctaa 2452861 atccatgccg tttttcagct cttccgcgat gactgtgaaa tcatcatata cgctttgaac 2452921 catttgttca gctgtttcat ttccagcagc ttctttgaca gaagccgttt ctaaggattc 2452981 cttcattgtt gcaatcggtt ttccgttcag cgccaaaaga cgttctgcta agtcatcaat 2453041 ataagttgct gtttcgttgt acagctcctc aaacttttca tgaagagtga agaaatcttt 2453101 ccctttcaca taccagtgat aattatgtag tttcacatac atgaccgtcc agttggctac 2453161 ttgtttgttc actgcttgaa tcaattgttc tgacatggta tctcctcctt gttatatgac 2453221 tatgtatacc cttaatatcg tacgctaaaa cctctttttt acccttatct gtcacgattt 2453281 cttctattat gctacaattg ttaaaaaacg ggaggtggaa tgtcatgacg cttctcatta 2453341 cgataagtat tttgattgtg ctggctgttt tgcttgtaac catttggacg actgtaaaag 2453401 cctataatgt aaagcatacc attgatccac cacaagaaaa tcactctgat tcacacaatc 2453461 aatgatgatg tgaatgctcc tcttctgact gattgctggc agcatcggcg tctccgactt 2453521 ggacttttaa ggtcggcatg ctatgctgtt tttttgctgt gacatgagat tggacagtgt 2453581 atacaccatc ttccttaaac gtcgtttcca atcggtatac gcctttttct tgtttcacct 2453641 taaacatttg gcttgcgtct ttttcccctt ctttccatac ttcaaactct acttcatcgg 2453701 catccgtcac agcttcatca ccatatgata cagctgcttc ataagcagcg ctttctccgg 2453761 gatttacttt ttcaggcccg gtcagcttga catccaaaac ctcgggcgtc tcagctgtat 2453821 ttgctttact ttcaccagat ccgcatccat taagcaataa agcagaaaaa agcagaacaa 2453881 ccaacatctt tttcatgcca tcaccctttc atcgtttacc taaatagtag caaacgctta 2453941 cagcaaatgg tacacaaaat atgagacgtc acaaaaaaga cctttttgct taagcgcaaa 2454001 aaggtccttt ctattttagc caaatacttt tagcaattct tctttatcct gtgaaagcca 2454061 gaaacgcatt aaacgtttag cgccttccag atcatgaagc ttcgcttggc cgcactgctt 2454121 ttcattcgca gcaggtattt ctgtaatctc taccgcttcc ttcattgtgt cttcaagcag 2454181 atcaacgatt tccgctgatg tcggctctcc gctcacaact agataatagc ctgtctggca 2454241 gcccattgga gaaatatcaa tgatatcaaa atgatcgtat ttctcagcgt gagaacgaat 2454301 cgtaaacgcg agcaaatgct cgagtgtgtg aatggtgtca ggcttcatcg cctgtttatt 2454361 tggctggcaa aaacgaatgt caaatttatt tacaacgccg tctgttccca ctttatgcac 2454421 gccgcaatgt cttacatatg gagcaacaac cgcattatga tcaagctcaa aactttctac 2454481 tgaaggcata atggcactct cccctttttt aaaaatgtaa tttcattata acatactttt 2454541 ccgataagaa ttattgatta acttttcaat ctgtgttttt tttcttatac ttgcatcaga 2454601 aaggttgctg aagaaacatg aaaaccctat tcatcgctct gatcagagga tatcaaaaat 2454661 tcatctcgcc cctgacaccg ccaacgtgcc gcttttatcc gacctgttcc caatatggaa 2454721 tcgaagcgat taaaacacat ggcgctttaa aaggcggatg gctgacaatc aaacggattt 2454781 tgaaatgcca cccgttccat ccgggaggag tcgatcccgt tcctgaaaag aaacaaaaac 2454841 attaattgtt ataaccgttt acgataagat ccagttttcc ggttttagga tcaatgacta 2454901 agccatggac cggaacgttt tcagggaaca gcgggtgatg tttaataaca tctacgctgt 2454961 ctttcacact cgcttccact gaatcaaagc ttttaaacca ttgatcaaag tctacaccgg 2455021 agtactttat tgtttcgatg cgttcttccg gaatccctct tgctttgatt ttttcaagca 2455081 tgcttttgct gctgattttg ctcatgccgc aatcgtgatg cccgatcaca cacacctcat 2455141 ctgcattcag ctcgtacact gcgacgagta tacttctcat gatgcttccg aatgggtgtg 2455201 tcacaagcgc accggcactt ttaatgattt tcacatcacc gtttcgcaaa ttcatcgcat 2455261 gcggcagcag ttcaaccaga cgagtatcca tgcaagaaag aatcgccatt tttttatctg 2455321 gaaattttga tgtttgatac ttttcatact ctctttgttc agtaaatgtc ttgttaaatt 2455381 cgagaatatc atttagaaga ctcatgttcg ttgtcccttt ctattctttt tactcttcaa 2455441 tatatcacaa cccttgttta ttcgtcataa taaaaaaaga caaaccctca ggcctgcctt 2455501 atttccccat gttatagcgt tttttgaact gctcaactcg tccgcctttt tcattgaatt 2455561 tctggcggcc tgtataaaac ggatgcgtgt cagagcttac ctctacttta atgacaggat 2455621 atgtgtttcc gtcctcccac tctgctgttt cattagatgt tttcgtagag gtgcttagaa 2455681 aacggtagcc gctgttgaca tcctgaaata tcactttgtg gttctttgga tgaattcctt 2455741 ctttcatggg tatctccttt caataaatcg taataattac gttttatttt ataaccttac 2455801 aaacgttttg tcaatcttct tatatccttc cctctgtttc acatcgtaaa cctcatggca 2455861 tttaagaata ggaagaataa tctaaccgag gaagcaaata ataaacccaa aatacataca 2455921 gaacgtcttt ttggaaaggt ggtttacgat tgtggatgat ttagttttgg ccagaagcct 2455981 ttttggcacg acgatgggct ttcatatcat tttcgcaaca cttggagtcg gtctgccgct 2456041 catgatttta gtggcggaat tgatctatca aaaaacgaaa gatgaccatt atgcgatcat 2456101 ggcgaaaaga tggacgaaag cacaagccgt tttgctgggg gtcgccatac cgaccggaac 2456161 gatcgcgggc actcagctcg cgcttttatg gccgggattt atggaagtca tcggccgggt 2456221 gatgtccctg ccatttcaaa ttgaaatcta tgcttttttt gttgaagccc tattcatgtc 2456281 gatttatgta tacgctgcag accgtttgtc acctgcaatg aggattgttg ctgttttctt 2456341 tgtgttagtc ggggcagcag catccgctgt tctgatcacg aatgttcacg cttttgaagg 2456401 tacgcccgcc ggttttaaaa ttttaaacgg aaaaattaca gatgttgacc cgtgggctgc 2456461 gttttttaat cctagctttt ttatcactgc cggccatgtc gtgctgtccg cgtttatgac 2456521 tggtgcgttt atcgtggctt ctgttgcggc gtataaaatg atccgaacga ggaaaaagga 2456581 aagggtctat cgctttcacc ggaaagccct tttgctcgca ctgacgatcg gcggtatttt 2456641 ttcattgctg accgctttga acggacacga atctgcacag atgctgtacg aataccagcc 2456701 cgaaaaatta gccggtgcgg aaggcctatt tgaaacaaga tcccacgccc cgctcgctat 2456761 cggcggtttt accgacccga atgaagaaaa agtaaaatgg gcaatcgaga ttccatgggc 2456821 tttaagcttt ttggcagcga accgttttga cactgttgta aaaggattaa atgcatttcc 2456881 gagagatgaa tggccgccgc ttttcattca cacgctgttt aatgcgatgg ttggtgtagg 2456941 catgctgcta attctttatt ccattatcgg tgtggtctgg agaaaggtgc tcaagaaaga 2457001 ccgtttccca acgtggcttt tgatcatttt catgacagca ggccctttta gtctcatcgg 2457061 cattgaattc ggctggattt tcgcatgtac ggggaggcag ccttgggtca tctatcatct 2457121 gctgaaaacg tcagatgtcg taacaacgac tggctcgatc ggggtgctgt tcttattttt 2457181 cacatttgtt tatgccgtgt taggcgcagc tgtcgtctac gtgctgctgt attatttccg 2457241 caagcacccg gttgacgaag atttaaatac agcggagtcg taatggctcc gcaaacagga 2457301 aaccaaatgg aaggaagatc gtacaaatgg agatttcaac tgacgctctg atcgccatct 2457361 caattatctg gggctttgtg tttatttacg ccgtcatggc gacaatggat tttggagcgg 2457421 gattttggtc tatgatctat ttaaacaagg agcatatgaa ggccaccgat attgcgaatc 2457481 gctttttgtc cccgacttgg gaggtcacaa acgtctttat tgtggccatc gtcgtggcgc 2457541 ttttcagttt tttccccggc gcgacatttg tgctcggcac cgttttatta attcccggaa 2457601 gcatgatttt gctgctttta gcaattcgaa gcggatttct cgtgttttca aatacagcaa 2457661 aggagcggaa aacgctaaga tatatttccg gcatctccgg ctttatcatt cctgctattt 2457721 taattttggt gcttcctgtg acacacggag ggtttataga aaaaacggat ggaatctata 2457781 acttaaatat gtctaaaatc ttttcaagcc ccaacgccta ttcatttatc gggtttgcga 2457841 ttttaagcac cttatttttg tcctcgctgt tgcttgcaga tttttcaaat gtggcagagg 2457901 aacaggatgc gtaccgagcc tacagaaaaa gcgccctgat taccggcccg atttcactgt 2457961 tgtttgctgt atgcattatg gtaactatgc ggaatgaagc aaactggctg tacagcggaa 2458021 tgatgaatga tttttcttgg attattgcat cgttcattac atttgtcatt gctggaatcg 2458081 ctctttttct gcctaacaaa agctttggtc aaaacatcgg aaaaccgcgt ctcgcacttg 2458141 ttgcgattgg gatacagtat tttctcgcaa gctacgcgta cgggcgggcg catcttccgt 2458201 atatgattta tcccgatgtg acagtcatgt caggcttcac agagccagca acgttcagag 2458261 cgctgtttgc aacgtatatc gttgcattta tcattctatt tccgggcttc tttttcttct 2458321 ggaaaatgtt tatgcgagat aaacgctata tccgccagga ggaatagagg gcaagccagc 2458381 cggctatact aatccagaac ctttataagg aggggatggc atggagcaga aaattctatg 2458441 tgaggtcaac aactgttctt attggggcaa aggtaacaaa tgcaccgctg atgccattta 2458501 tgttgtcagc catactggtg aaacggctga aaacagccgg gaaacagact gcaaaacgtt 2458561 taagccgcat gatttataat taaaagaaag agctgcatca gccagctctt tctttttgca 2458621 tgttgagtgt tctcagcttt ttagttatga ccccgtttgc aggtgaaaac aaaaaggcgc 2458681 ttgcataaca tacacctgtc atggccgcca tcgctcctga aatcgaaaca ttaagccacg 2458741 ttgcgaagaa atagcccatg accgccgaca gcccgccaat caacgcgctg agaatcagca 2458801 tataaagaag ccggtctgtc agcaaatgtg ccgcagccgg cggaacaatc agcatggcca 2458861 caaccaatac ggcacccacc gaatcaaagg aagcaacagt cgtcaaggac agcatgccca 2458921 tttgcacgta atgaatgagc aaaaccggta ttcccaaggc taaagccatt tgaggatcaa 2458981 acgaagcgat tttaaactcc ttatagcaca cactgatcaa cactacgttt aaaaccagaa 2459041 cagatgccag catccaaaac gctttcggcc caatatcaac cccgaatacc gtcaccgtat 2459101 tccacggcac aaaagcgatt tctcccatta acgagtgctc aatatcgaga tggacattcg 2459161 ctccatacac agaaagcaaa ataaccccga ttgcaaataa ggatgtaaac acaactccta 2459221 tggcagcatc tgattgaacc cccttgctat gaagaagctg aaccaagaaa gccgttaaca 2459281 gaccggttgc ggctgcgcca ataaacatat aaatcccatc gagacttccc gtcactagaa 2459341 aagcgccgac aatgccaagc aacactgtgt gactgattgc gtcggccagc atcgccatgc 2459401 ttctcagcac aagaaatgtg ccgatcaatc cgcagcttac accgactaat acaccggtag 2459461 ctataatcca tgcttcaaaa ctcatttgcg atctgtccct tctcggcatc atgagacgct 2459521 tttcgacgct caggcatccg tccatacagc tttaagagtg aataaagccg ctctctcgtt 2459581 tctctcggta aacggtccgg gtcaaagtag tcctgatcgg attctatatt ggcaagttcc 2459641 atttcatgca tgagatacac ttcatacatc cgctgcttca aagctgtgtg atagcctttt 2459701 tctatccctt tgcttgtgat ttgccaaatc ccattttcga tacgctcaat gcacctctct 2459761 tgttccaagt catttaatgc cttaaggcat aatgaagggg ataggcgtct tttctttctt 2459821 acactttcaa cagttacaca aagattattc ttttcatact gttcataaat cgccaaaagc 2459881 acttgctccc tgcttgttct gcgccgcagc ctcatcagcc ttatggcttt agcagccaat 2459941 ccccgcttag gcgcgcaaat cattgaaaaa agaaagagca gcgttgcaga taagatcatt 2460001 aatggccctg tcgccattcc cttcatcgtg gtgctaagca gggttccggc cactccgctg 2460061 accccgcctg taatcccggc aatgatgatc atcccggtta atcgttcggt ccaatatctc 2460121 gcggttatgg caggtgtaat cagcatagcc gccattaata tcacaccaac agtctgaagc 2460181 ccaatgacga cagcacagac aatcagacaa gccaaaagcc cgtttaaaaa acgcaccggg 2460241 attcctaatc cctttgcaaa cgcgagatca aaagtaatca atgtaaattc cttaaagaaa 2460301 acaatacata ggagcagtag aacagcggat atccctgcaa taaggatgat atcctgcctg 2460361 accaatgaag cagcctggcc gaataaaaaa gaatcaagcc cgctttggct tcccgccccc 2460421 tgttgctgaa tatatgtcag cagaatgatc ccgacgccaa aaaacacaga aagaacaatc 2460481 ccgatcgccg agtcctcctt tgtttttgaa agccgaggaa tcagctgaat acaaaacgtt 2460541 ccgagcagtc cggcgagcgc tgcccccagc aaaaagaaag gcagtgattt ttgcccggtg 2460601 aacagaaaag cgagacacac tcccggcaga gctgaatggg ccatcgcatc gccgattaaa 2460661 ctttgctttc tcagcagcac aaagctgccc aaaacaccgc ttgccgtccc gagcaaaagc 2460721 gtaccggcca gcacccactg tgtattcgga tgctgaagct gcagccacaa actttcaaac 2460781 attgcgctca ctccttatgt ccttctgcca gcactttatc ttttaaaaac gtaagccttc 2460841 ctccatatgt tttttgcagg ttttcgatcg taaaaacgtt ttccgtcggt ccgaaagcga 2460901 ttttccttaa atgaagcagt aagatccaat cgaaataatc ctcggcggtc tgcagatcat 2460961 gatggacgac aagcacggtt tttccttttt ctttgagttc tgccaacagc gtcataatcg 2461021 cgcgctccgt cgctgcatca acacctgcaa acggttcatc cataaaataa atgtcagcgt 2461081 tctggcagag tgcccgggca agaaacaccc gctgctgctg tccgcctgac agctggctga 2461141 tttgcctttt cgcataatca tgcatcccga cttttgttaa tgcggccttc gccatctcca 2461201 catccgcttt ctttggcctc tttaataaac cgattctccc gtatcttccc attaggacga 2461261 catcgagcgg gcttgtgggg aaatcccagt caaccgagcc gcgctgcgga acatatccga 2461321 ttctggtccg ctgatcctta tagtctttgc cgtaaataga gatgtctccg gaagctctgg 2461381 gcacaagacc gagaatcgtt ttgatcaagg ttgattttcc cgcgccgttt gggccgataa 2461441 tgccaataag ttttccttca ggcacctgca gcgaaatgtc ctgcagtaca ggctttttat 2461501 gataagcaac cgtcacatta tcaagctcaa cagggaacat atcctccacc tcttttcttt 2461561 atttaagcgc tttagtaatc gtgttgatat tgtggcggaa cattccttcg tatgtgcctt 2461621 cttttgtgcc cttttcaccc atggcatccg aataaagctg accgccgatt gtgactgtat 2461681 ggcctttttc tttagcgcct tccaccactg cattgattga tttttcagat acactgcttt 2461741 ctacgaacac agcttttatt tgtttttctg tcagaagatc aaccagctcc tgaacatccc 2461801 ttaatccata gtccgaatct gtgctgagtc cctgcaggcc ttttacctta aatccatact 2461861 cattcccaaa gtacgcaaac gcatcatgag cagtcacaag cacacggctt ttctccggaa 2461921 tatgtgcgat ctccttacgc gaccacttat ctaaatattg caaatcttct ttgtactctt 2461981 tggcattttt ccgaaaggca tctgcgtgct gaggcattgc tttgctgaat tgcgcttcaa 2462041 tttcatccac cgcatagatc cataacggaa tgctgaacca gacgtgggga tcaaacgtct 2462101 tgccttcccc cgcgggaata agcttatttt tcggaatggc ctcagctact gccgccgatt 2462161 gtttttgttc gccgattttt tggaggacat cctccatttt cccttccaaa tgcaacccgc 2462221 tgtacagaac aacatcggca gacattaatt ttttcgtgtc accttgggaa gctttgtaaa 2462281 ggtgcggatc aacccccggt cccattaaag aggtgacttt tacgtgctta cctccgatgt 2462341 tttctgctgc atcggcaatt tgagatgttg tcgctgtcac ttgtaattgc tgatcagcgc 2462401 tttttccggc tgaatccgtt ccgcatcccg ttaaagcaaa ggtcgcaaaa agtactgctg 2462461 ccatcagccc ttgtctcata tttctcctcc tctttgccat caatgtccga ttgttttatc 2462521 ttatgttgtc agttcttaga catgtgacat taaattagcc aaaagcatgt tttatttaca 2462581 caggacaaaa agtttccctc atgcaaaatt atcgcgtttg gccatttttg tcaagctgat 2462641 ttacataaaa aaaccggctg ggtcagcagc cggtccaaac gagaagggat gtattcaacg 2462701 aacactttta ctgtaacagc acagtgtcat ttattcaaaa tagcaaaatg cttttttctt 2462761 aaccatgctg tgtgaaaaca tccattttgg tcacatattt tcgcataata tcttggttta 2462821 cctcaacccc taaaccaggc tgttttgaca cagaaataaa tccattatca atacgaatat 2462881 caggagttac aatatcttca tcccaatagc gtgaggatga agatatatcg ccaggtattg 2462941 tgaattgagg cagtgaagca agcgccacgt tctgcgctct tgatatgcct gtttccagca 2463001 ttcctccgca ccaaacctgc atatgatgct ctttgcataa atcatgaatt tttaaggctt 2463061 ctgttaagcc gccgacacga gaaggtttta tattaataat tttgcagctt cctagctcaa 2463121 tcgcccgtct cgcatcatca actgaacaaa tgctctcatc aaggcaaatg gccgttttca 2463181 aatgtttctg caagtggcgg tggtcaacga tatcgtcagc ttggagcggc tgctcaatca 2463241 tcattaaatg atagtcatca agctccttta aacggctgat atccttcagt tcgtaagagg 2463301 aattggcatc ggccataagc gggatggttg ggaatcggct gcggatggcc ttgaccaatt 2463361 ccacatcctg cccaggctga attttaattt ttattctttg ataaccttct ttttgatagc 2463421 tctcaatttc cttcagcata tcgtcaagag gcgccaggcc gactaccacc ccggcaggga 2463481 ctttatctct tgttccgccc aatgcctcag caagggatac gcccttcttt ttggcataaa 2463541 tatcccatac agccgattca agtcccgctt ttgccatccg gtttccttta taccgcgcca 2463601 ggctgtccgg cacttctgaa gggtgattga attcacggcc gacgacattt gggataaaaa 2463661 aatcttttag catatgcaaa catgttccaa tggtttcctc ggtgtaccaa ggcgaagaga 2463721 aagcggaaac ttctccccag cctgtgacac ctgatgtatc aatggcttcc acgatcagaa 2463781 atttacgctc ttgaagcgtt tcgatactgt ttttaaacgg tttctttaag ttcatgctca 2463841 aatggtaaag cgtgattttt tctatttcga tcatagcagt tctcctttac gcgcatcctt 2463901 cagctgattt cgcaagagct tattagacgc attgcgcggc aggcggtcaa gcacaaagaa 2463961 ttttgccgga attttatact tcgccaagcg ttctttgcag tagtcagtca attctcctgc 2464021 gctcacaggc ttgtgaagga caagataggc gtgaggcact ttcccccatt ttttgtcctc 2464081 agcccctgaa accccggctt cggccacagc ggggtgtgaa agcagcactg actccacttc 2464141 ggccggataa atgttttctc cgccggatat gatcagatct gaacgtctgt ctaatacata 2464201 taaaaagcct tcattgtcca aataaccaag atcacctgtt ttcagccagc cattttgaaa 2464261 ggaggcttcg tttgcgctct cccggttaaa atagcttttc atgacattcg ggcctttgac 2464321 catgatttca ccgtgttcat acggttcaca tacctgtccg tcccgctcta ttttgatttc 2464381 acacgaaaac agcggtttcc ccgcagatcc gagcttttcc atgctgaatt ccggcgacag 2464441 ggtaacaatt tgcgagcatg tttctgtcat tccatatgac tgaaagacag ggaatccttt 2464501 ctcacggcat tcctcaagca atggcagcgg tgcaggaccg ccgccgagaa gaatgcatct 2464561 gatggattca gggcagcggt ttgtttcttc caaaagactg gccagcatag tctgcaccgc 2464621 agatatcatt gtcacttcat gcctgttgat agaatgcagc acatcgctta cggaaaaacg 2464681 ctggtgaagc acgacagtca ttccatagat cacagattta aataatgcgg acaatccgct 2464741 gatatgaaag agcggcaatg cgataagcca gcggtcttgt tctgttatac ccaaattaag 2464801 agcggacgac accgcactga aataatggtt tccgaacgtt tgctgaactc ccttgggctt 2464861 tcctgtcgta cccgacgtat acatcagcgt tgccgttgca tccatttgca tataagcctc 2464921 gatctcaatt tcctctgctg cttctttcat cagttcatcc acatcaatcg tttgaacgat 2464981 gtgttcatat tctttcttct caaagcttga atctgtcaat aaaaagccgg atcccgaatc 2465041 ctccagctga aacagccttt catgtgttga cagcttcgta ttcaaaagca ccgccttaac 2465101 accaagcaaa aaacaagcgt gaacagcgta taccatttct gcacggtttt ggagcaaaat 2465161 agctgcagta tcccctttcc gaaccgaatg agcggcaagc tgttccgcca ttcgtttaga 2465221 cgcggcaaac aattctgcaa atgtcacggt ttggtcttca tagatgagag cgattctctc 2465281 aggtgtcagc tgtgcccgct gcatgagcca gttgggctgt tctgtcagca tgtcatcatc 2465341 tccgaggtaa aatgtctgta ttgaaaagaa aacagcttgg accgcaaagt ctcaagctgt 2465401 tggtttacta gatattgctg atcacggaaa acgagggaac tgtccgaaat caggtttgcg 2465461 tttttcctta aaggaatcac ggccttcttt tgcttcatct gttgtgtagt aaagaagggt 2465521 agcatcccct gcaaactgct gaattccagc aagtccgtct gtgtccgcgt taaacgcagc 2465581 tttaagaaag cgcagtgcgg tcgggctttt ttcaagcatt tcttcacacc atttaatcgt 2465641 ttcttcttca agctgttcca aaggaacgac tgtgttgaca agacccatgt ccagtgcttc 2465701 ctgtgcgttg tactgacggc ataggtacca gatttcacgt gcttttttat gtcctacaat 2465761 tcgagccagg tagccagaac cgtaacctgc atcgaagctt cccactttag ggcctgtttg 2465821 tccaaaaatt gcgttgtccg cagcaattgt caagtcacat acgatgtgaa gcacatggcc 2465881 tccgccgatc gcatatccgg acaccatcgc aacaaccggt ttcgggatga cgcggattaa 2465941 acgctgaaga tccaatacgt taagacgagg gatctggtcg tctcctacat atccaccgtg 2466001 gccgcgcact ttttggtctc cgccagaaca aaatgctttg tcccctgcac cggcaagcac 2466061 gataacccca acgttttggt cgtctcttgc gtcagcaaac gcatcaatca tttcagcaac 2466121 cgttttaggg gtaaacgcat tatgtacctc aggtcggttg attgttattt ttgcaatgcc 2466181 attatacgtt tcatacaata tctcatcgta tgtccgtttt gttttccatt cagccatatg 2466241 atgacctcct tttattctct atgtgaatga gtcagatgct tgtcaaaaac tcactcacta 2466301 ttttaccaaa caatcgcggc tgctccacat ggaccgtatg tcctgctttt ggaacaatct 2466361 ctattctact agaaggaagc atcttatgca cctcttgatt gatggcgcaa aatttttcgt 2466421 cccactcccc gcagatcaga agcacaggaa catctatttc ctctacacgg ctccacaagg 2466481 aaggctgtga accggtgccc atgccggtta aactgttcgc aagcccaatc ttattgttcc 2466541 gcagacggcc cgatcgtatc ctgtaccgaa tatcttcagc cagcctctgc tgagatgaaa 2466601 acaaagggat attctcccaa tacgcaacaa acgcttcgag cccgtctcgt aaaataaaat 2466661 cagcaagctt ccggtcccgc atgattcgtt cccgccgttc cccaagtgtt ttgagccccg 2466721 gcgtcgtgct ttcaagcaca agtgccgata cccgctcggg atatgtcatc gcaaaagagt 2466781 aagcaagcct tcctcccata gaatacccaa tcaatttcac tttgtgaagt tttaattgat 2466841 caaaaatctc ggcaaggtca gaaacttgcc gggttgtgct gtatcttttc ccattcagcg 2466901 gggcatcggt ttccccatgc cctaaacaat caattttgat caaacgggaa tcaggcagca 2466961 tttcatcaag aaaagtccat gattgtttgc tgccggtaaa cccatgcaga cagacgacgg 2467021 cttcggaagc attcggtccc tcgtctgcca ctgcatatcg gacaccatct gataccgtta 2467081 tgtttacagt tcccattgtt ttttcacttc ccgcacagcc tcattcagca tatcgcgatg 2467141 aagctggact cttgattggc gatccgtttt gatttcaatc aaatggagtc cgggcttgtc 2467201 tgcctgcggc gcgtaagctg ttttgaattc atcccaagaa gccgggcatg aatacgttcc 2467261 gccgtaaagt gcagccgcat gcttgaaatc gagccctgtc ggtgtgccga acaaatcttc 2467321 aaagtgtgtc ttctcagaag cctgcggcaa aaaggagaaa atccctcctc cgtcattatt 2467381 gacaagaatc acagtaagag gaatacccag ctttttggcc gccagcaggc cgtttaaatc 2467441 atgataaaaa gataaatctc caatcacaag ggtaacaggc gcttttgttc cttcacatac 2467501 ccccatggca gaggagacga caccgtctat cccgtttgct ccccggtttg aataaatccg 2467561 gaaagggcgg tcctgctttt caaaaaacgt atcaacatcc ctgatcggca tgctgtttcc 2467621 cacaaacagc gagctgtttt caggcacaag atgctgaagg attcgataga gattgccttc 2467681 aaacgaaaca tcttcactgc tgattgtttg cagatgctcg cggaaccgcc cattgacaaa 2467741 ctgccacttt tccagccact ctgaggatct ggtggcagca gtaaggcctg ccatgatctc 2467801 ctcagcaaaa acagacgcat tacaatgaat catatgcgcg cttgcctgtg tcgggtctct 2467861 ccaccctcca tcctcgtcaa tcacgatttg ctgaatcgtc ggatcatcct taagccataa 2467921 gaaaaccggt tttgaaacag gcatcggtcc aaaccgaatg acaacatcag gacggagttt 2467981 ccgcttcagc tcatcatctt ttaaaaacga atcatacgca tcaataacag tgcttttatc 2468041 atgaacacca ttccgcagat tagacagcgg atctgctaaa attggatact gaagcgcttt 2468101 tgacagcgca ataatgtttt ccttgtccgc atcactatgg agctctccgc agacgatcat 2468161 tcctttttca gcctctgcga gcatctcagc cacatcagac agggactctc ggtcaacaga 2468221 ctgcgtaccc gttttcacag acacatgacg gcctgttctc attcttccaa acggctcatc 2468281 tgaaagatcc ggcatcagcg gttcgcgcag cggcacattc acatggacag gccccatcgg 2468341 gcgcttttgt gcttctccgg cagcgcggct tgccagcgtt cggatgtatc tcagcatttg 2468401 cggagactct tcaggaagag cagagtctgt gaaaaactta acaaagttac cgaataagaa 2468461 gtgctgatta atagcctgcg gtgcgcctac ttcgcgcagc tcatgaggcc gatcagcagt 2468521 taacacaata ataggcaccc ttgaataatg ggcttcaacc acagccggat aaaagttggc 2468581 cgcggctgtt ccagatgtac agatcaatag tacgggacgc tgcttcgctt ttgccaaacc 2468641 taatgcaaaa aatccggcag acctttcatc aatttggaca tggacgctga tatcgggatg 2468701 cgcagcacaa agaacagcca gcggtgtaga tcttgagccc ggacaaacga cggcgtccgt 2468761 aattccggaa agggcgaatt catcaataaa acttccgatg taatgagtaa tcgggttgac 2468821 tgtcaacgcc tctcacctcc taatgcagag atcatcggct tcaatttaat ctgtgtttct 2468881 tcatattccg agattggttc cgagtcttcc acaataccgc acccggcaaa cagccttgct 2468941 gtgcttcctt cgatgagccc tgaacgaatg gcgaccgcga attccccgtt atcctggctg 2469001 tcaatccagc cgataggggc cgcataccag ccgcgggaca tcggttcaat ctccctgatc 2469061 acgtcaacag ctttttcctg aggtgatccc ccaagcgcgg gagtggggtg cagcttctca 2469121 attaagtcaa aaatcgaagc agactcgcgc agctgtccga caatcggcgt aaacaggtgc 2469181 tgaacgcttt ttgttttgta caaaacaggt ccatcaggct tttcaacctc tgaacagctt 2469241 gatacaaaag cattatgaat catacctacc acaatatcat gctcaagcag gtttttctca 2469301 tcgtttaata attcaaggcc tatccggcgg tcgtcttctt cattcacgcc tcgtttaatg 2469361 gagcctgcca gacaggaaga catgacagtg ccgccgtctc ttttgatcag tctttccgga 2469421 gacgcgccga caaaggtttt gccttcttgt tcaattgcaa aaacatagct tgtctgctga 2469481 tcgtccagaa gcgttttaag caccggttca atttggattg gaccgtcaaa cgtgagcagc 2469541 agctctcggg caagaacaac cttatcatat tgtttctctt taatttggct tgtggccgtt 2469601 tcgattgctt tcagccaatc atccttatcc agctcttcgg ctgctgcaat cacagcctga 2469661 tcttcttgct tgaaatcggg aaccataaat tccgccgcaa aagcttttaa gccttctaaa 2469721 acagcttctg cgtcttctcc tccgcttacc catctgttaa ctgttaagaa cgggccttca 2469781 gcagtcatcg tcagcataag cgcaggcaca aagaaatccc cttccgagaa atggtcccat 2469841 tgtgaacctc tttcttcgca agggtcaaaa gaaaatcctc cgaataacac aggtcccact 2469901 gcagaatgct gcagcttttc ttcttcataa atatgaaaag ccgtcttttt aaagcgctcc 2469961 cattgttcaa aaacctcacg ataccgctcg ctgttttttt gatttgtctg gaaaaccgct 2470021 tctttgccaa gaccgactat tgtcaattca ctttcaggat ctgaccaaaa aaatcgattg 2470081 cctgtatatt tttttgctcc gtaattgaaa aatgatagag ggtcaagaga ctcgatttgt 2470141 ctcgaatagc ttattaagac agcatggttg acttctttgg ctttatgtaa tgcatgtaga 2470201 acttcctttc ggaacgtacg ctgcaccgtt gtcaccatga gacattcctc cataatcctt 2470261 aaaatgcttt taataccata cacctgtgtc tcctttgtgt caaacacaga tcatgcagtc 2470321 caaatggcct gccttaccta ttataaacct aatttcagaa atgaaaaaga aacaaagctt 2470381 aaatttcttt ctccactgat agcaaaggtt gtatccgctt accataaaag gaaaacctcc 2470441 tatattcctc cacccgccat ttatgaaagt tctcaggcga tctgttcata ctaaaggtat 2470501 gcatcacaga gaaacgaggc gatcacattg cttacgaaag aacagcttca gcatttaaaa 2470561 aatgaactgg aacaaacgaa aaaagatatc ttaaaccgtt tcaaagacaa tgatcatttt 2470621 cagcttaact cagcctttcc ttatgattcg tggggtgagc tttcggcata cgacaaccat 2470681 cccggcgatc aggcgacaga actttacgag cgtgagaaag acatcgctct agacttgcat 2470741 gagagagagc accttcggga cattgagcat tcattgaagg cgatagaaaa cggtacgtat 2470801 ggcatttgtg aagtcagcgg aaaggaaatc cctttcgaac gacttgaagc gcttccgact 2470861 gccacaaccc tcgcggagta ttcgtcacag gacgtggttt ccaaagaccg tccgattgaa 2470921 gaagaaacac cattcgggca atttgaattt gatgatgatg aagaaatcag agcgccatat 2470981 gacagtgagg attcctatca ggatgtcgaa aaatatggga actcacaaac gccgcaggat 2471041 atggaaaacc ctccgctcag ctatgatgat atgacgatga atgccgaaga gaatatcggc 2471101 aatacggagt cttacgaaaa tttcatcgct acagatatca ctgggaaaga aattaccgtt 2471161 tatcaaagca gagcccatga gcgctatgaa gaagaacttg acgaagaggg aatcatgacc 2471221 acattcggcg atctccacgc tgattgaacc cccaattatt gggggttctt ttccgttttc 2471281 agcatatcgt aaatcagctt cagataatcc ttttgcaggc cgatgtcata ccgctcgccc 2471341 tctagcaatt tcccgtatac ggtacatgcc ccgagcgaag cttttatcgc atccgttacc 2471401 tgcacttctc ctccgctatc agcttctaat gcctccagct cattaaaaat atccggtgtg 2471461 aaaatataac gccctgctgc ggcaaaatga gacggagggt tttgtttagg cttttccaca 2471521 atatcctgta tgcgataaag ccctttttca acaggctccc cttttatcac cccgtaatga 2471581 tgtaaatcct ccgtttttgt ttcttttaag ccgatcacac tggactgata tttcgtatac 2471641 gcttcaatca gctgccccaa agccggctga ttggcggaaa aaatcagatc atctggcaaa 2471701 acgacggcaa aaggctctcc tcctgcaaat tgctttccga aagaaatggc gtcgccaaga 2471761 ccctttgcat aaggctgccg cacatagtga atccgtatat ccggaatggg atgctctcta 2471821 agtaaatgca gtttattctt agaggccaaa aaagcctcaa gtgccaaaga ggaatcaaaa 2471881 tagtcgacaa tcagattttt atggctcgat acaaccatca aaatgtcctc aatgcctgac 2471941 tcctttaatt cttcaacaag ataatgaatc acaggcttag atcctaccgg aaacatttct 2472001 ttcggaatca ccttcgtcac cggcagattt ctcgtgccga atccgcctgc aggaatgatc 2472061 gcttttttta tcatggtatt ttcccctcag ctcatgttta ttacatgata ttccaagagc 2472121 gcatcccgat gtttgtacat ctgaaattag gcggaagcaa ctgggcagaa agcggaatca 2472181 cgaaccagcc cttttttaat aggatattga tatatgacca gtaatcttgt aaaggagctc 2472241 aggtgatgaa aatttgtgtg gttggcgccg ggtatgtcgg tttaacccta tcagcggcac 2472301 tggcatccat cggacatgac atgatatgca cagacaaaga cgtcaaaaaa atcgggcagc 2472361 tgaaaaaagg agtcattccc ttttacgagc ctgggctttc agatgcaata cttcgttgcg 2472421 gcaatctctc gttttcttct gaagtgaaat cgagcatgga ggaatgtccc gttattttta 2472481 tcgcagtcgg aactccgccg cgttcggacg gatcagctga tacgaaagcc ctgcagtccg 2472541 tcatcggtga tttaagcgag gcgatccgat cgtataaaac cattattacg aaaagcactg 2472601 ttccgcccgg gacaaatgaa aacatagcaa aacagctgat tgcctccgga gtgtctaaaa 2472661 acctctttaa tatcgtatcc aatccggagt ttctgcggga aggcaatgcc ttatatgaca 2472721 tgctgcatcc tgacaaaaca gtcatcggtg ttcaggaaga agatcacgta tcggcagcca 2472781 tcgtcaaatc catttacaaa cacattgata ccccttttat cgttacaagc ttagcgggag 2472841 cagagctgat caaatatgcc aacaatttct ttttagcggc caaaatttcg ttcattaacg 2472901 aaatggcccg catatgtgaa gcctatcaat cagatatctc agatatttcc cgcgctatcg 2472961 gtctagaccc aaggatcggg aagcactttt tgcaggcagg catcggatac ggaggctctt 2473021 gttttccaaa ggatctgcag gcgctgcaat ttgctgccca ggaaaaaaac acggagacct 2473081 tcctgctccg ggccgtgcag cacattaatg acacccagct tggcctgtat atcaaaaaaa 2473141 tacagtcatt cttcgaaaca cttcaaggca agaaagcggc tgtactcggc atttccttca 2473201 aaccgaatac tgatgacatc cggaattctc aggctgtcag actgatggaa aggctggcgg 2473261 agctgggatg tgatgttcat gcatatgatc ctgaagctgt acttccagaa catttgcggc 2473321 aacatgtaac tcagcattct caagcttttg atgcgatcga agagagtgac tttttatttt 2473381 tggcgacaga atggtctgag tttttagcgt ttgattggaa aaaggctgca gatatcatga 2473441 aagggcgtct tgtgattgac ggacgcaacg tactaaaaaa agaactgatc gaggcttgcg 2473501 gcctgatctg tacgggagtt ggccgtccat gaaaatactc gtcacaggag cagcgggctt 2473561 tatcggctcc cacctctgcg aagaattact aaaagataag aaacataacg ttatcggaat 2473621 cgatgacttt atcggtccta ctccattttc cttgaaatta aaaaacctta aaaacctgct 2473681 gccggaaaag cgatttacgt tcataaagga aaatctgctg acagccgatc ttgcttcctt 2473741 actggaagga gtggacgtca tctttcattt ggcggccata ccgggtgtcc gctcaagctg 2473801 gggcaatcat tttcacccat atgccgcaca taatatccaa gcgctccaaa ggctcctcga 2473861 ggcgtgccgg gaacattcta ttcaaacgtt cgtctttgca tccacctctt ccgtctatgg 2473921 cgaaaaacaa ggaaaagtca gcgaaaacac gtcgctttct cctttatctc cgtacggggt 2473981 aacaaagctt acgggagaaa agctttgcca tgtgtataaa cagagctttg gcattccaat 2474041 tgtgattctc cgttttttta ccgtatacgg gccaagacag cggccggata tggcttttca 2474101 ccggctcatt aagcagcacc ttcagcaaaa gccgcttacc atcttcggtg atgggcagca 2474161 gtcaagagat ttcacttata tcagcgactg tgtcaaaggc atcaccgctg ttcttgggaa 2474221 accccacctt attggtgaaa cagtaaatat cggcggcgca gagcgtgcct cagtcttaaa 2474281 agttgtctcc ctcattgagg atatttccgg gagaaaagca acactgcact tttcggacaa 2474341 aatagcaggg gaaccgagca acacgtgggc ggatatttca aaagcaaaac agctcttgca 2474401 ttatgatccc gccacatcct taaaggatgg cttgaccaac gaaatcgcct atttatcgtc 2474461 gctgtatcag ggggaataaa aatgaagctt gcctttatct gtacagaaaa gctgccggcg 2474521 cccgcagtac gcggcggcgc tattcaaatg atgattgacg gtgtcacgcc ctatttcagc 2474581 agcaggtacg acctgaccat tttttcaata gaagatccat cgctcccaaa aagagaaaca 2474641 aaagacggcg tacattatat ccatctgcca aaagaacatt accgcgaggc ggtagccgaa 2474701 gagctgcgag cctcttcctt tgacctcatt catgtgttca acaggccttt aaatgtctct 2474761 ttatataaaa aagcctcacc aaacagcaag atcgttctga gcctgcataa cgaaatgttt 2474821 tctgaaaaaa agatgacctt cgcgcaagga aaagaagtac tcgacaatgt ctccatgatc 2474881 acaacagtga gcgaatttat taaacaaacc gtcattgaac gtttccctga agccgaggac 2474941 atcacaaaag ttgtgtattc cggcgttgat ttaaactctt atccgcccgt ctggacgatg 2475001 aaaggctcgg ctgtcagaaa aacataccgg aaaaaatacg gtattgaaga taaaaaagtt 2475061 attttattcg ccggccgctt aagcccgaca aaagggcctc accttctcat tcacagcatg 2475121 agacggattt tgcagcagca ccctgatgct gtactggtca tagcaggcgg gaagtggttc 2475181 agcgatgaca gcgaaaacca atatgtcacc tatctgcgca cgctggcgct gccatacaga 2475241 gaccacataa tctttacaaa attcattccc gcagacgata tcccaaacct ttttctgatg 2475301 gcagatgtat ttgtgtgcag ctctcagtgg aacgaacccc tcgcccgtgt gaattatgaa 2475361 gcaatggcgg ccggcacgcc cttaattacc acaaaccggg gcggaaacgg tgaagtcgta 2475421 aaacacgaag tcaccggcct tgtcatcgat agctacaaca aaccttcttc atttgcaaaa 2475481 gcaattgaca gagcctttac agatcaagaa ttaatgaaca aaatgacaaa aaacgcccga 2475541 aagcatgtag aagctttatt tacctttacc catgctgcca aaaggctcaa tactgtttac 2475601 caatccgttc tgaccccgaa aaacaaacaa tttccgccgc cttttctgac gcaaaatttt 2475661 gatttatcat ctatcaatca gctttttgtg aaagcaaaaa cataaaacct acagctcgtg 2475721 ttgcaaaacg ggctgttttt tcgctacaga gaacttaaaa aaaggcataa atgtgacttt 2475781 atgccttgcg ctttacagtt tgagaaaacc atggagctgg tttagattca cttggaagaa 2475841 tgatgatttc cactttagct tcttccgcta agtctggttc ttcatcttca tcctcttctt 2475901 catatggggg cgctgagcgt ttcgaatcac gctcctcctc aggctccaga gtggtttcga 2475961 attttgtttc ttcttcatca tcgacgattt tgcgatctgt ttccttttcc ttcgtttctt 2476021 tttgatattc tttcggtgca ttgatgtgag ggagctctcg aatgctgccc acatctaaat 2476081 gcttctcctc ttcttccttc tcagctgaga ttgagtcatg agcctgccat cccatcggtc 2476141 caggcggtgt aaatacgaat tggtcgagat ccagtttaga aatagaggct ttttgtctcg 2476201 atgacctcat gtcaattcgc ctcccgatac gcttttatct ttttatacag ttccggcagt 2476261 ttatccaaaa acgaatcttt agattcttca acagaaatca tgttttgcag cgcccagtta 2476321 tacttctcat ctgaccacgt tttcttttgc ttcaaataat atttgtgccc gattgcacag 2476381 aacaaatgcg gaaacgcgag atcaatccaa agtacctcgt actgtttttc tgtgagcgga 2476441 tacactgcgt cgtaggccgc aagcagtgca accatgaaat cagtatccca tacagaaagc 2476501 ttaaccatca ctttattcag cagaatacga aggtctcttg acggcaaatc gtaggtaatc 2476561 gagtgaagct cctttaaaaa aggctcccct tcgatctcag tcaaacgtgc caatgtaaaa 2476621 tcctgaaaac agaatccgcc atgctcgagt gtctcttttg tccaggtttc gtattctgag 2476681 tcatcaagcg ctctgagagc ttcttttcct cttgccagca ttttatcagc atgttttaag 2476741 aaagtttgcg aaaatacgtc atcaggatag gatgctgcga tctgcatatt cccttcaagt 2476801 tcctgcagct tccaacggta caatttgtgc cattttccca gcctgcttct cttcttgctt 2476861 tcatctgtgc aaacatatcc ttttgaggca tgatgaaaat ggccggcaaa tgacatgact 2476921 tttttcattt gctctgcatc atagtaaatc atttcttttc ctgtcacttt gtcatataaa 2476981 ctgtaagaaa cctgatccgt gcccaagcag ctaccgccat tttttgtttg atgaatcggc 2477041 gctatcggca gccctttctc ttgtaaatgg gcgtgtgcct gagtgataaa aagcatccgc 2477101 tccggtttca tttgcgcttc ttttagcagc tttgggccat gatcagtttc gacttcccag 2477161 attttgcgcc cgcttttgtt cgatttcagc gccacatggt cgatatgaaa cggataataa 2477221 ctgagaattt cggacacaat ctgttcttca tgctcttttt ggtacactct gttcacccct 2477281 tctatctgtt cttttcatag acgctgagca gattttcagc caccctctgc cagccaaaat 2477341 tgctttctgc ctcacggcgg ctgtatttcc caagccgttc ccgcttttcc gagctgctca 2477401 gcaaatcatt gatacgttcg gcatattgtt taggattttc aaagtcatga atgatgtagc 2477461 cgtttttccc ttcctctatg acctctggat tgcctccccg attgcttgta ataataggaa 2477521 gtcccgcagc catcgcttca taatgcaccc ttgctaaagg ctcctgccat tgcgaagagc 2477581 atacaaatac atctgacatg gtataaaggc gcggaatgtc ctttggcttc acaaattgaa 2477641 taaatgtgac atgatccttt tgcatcgcac caagggtatg aagatgtttg acatagttat 2477701 ttaattcatt atctccgaac cattttgacc cgataaacac catcatgaca tcggggtgct 2477761 cctcaatgat gtccggcaaa gcctgcaata atatgtgcgg gcctttgact ttgctaagcc 2477821 ggccgacaaa caagacgatt tttttgccgt gaagccccag ctcgcttcgc atctcttcgc 2477881 gagctcgctg cccttcattc gtccagcgag ggtggtacgt ttttaaatcc acaccagaat 2477941 acaccgtttt tgtttttgat cgtgctgacg gaaaacggct tgtgatcgtc tgtccgatat 2478001 aatcgctgac cgtaacaatc tgcgctacgg agtcgatgca aatctcgcct tccgcctggc 2478061 tgattttatc gtaagcgaac atttcattgt gaacgcttaa aataaaaaca gcatccggcg 2478121 cctgtttctt caatttcgga acccagcttg ggcgattaca aacatgcaca agatcaaaac 2478181 ggctcttttt cagctctgct ccaacggctt cttcataacg gtcttcatcc aaatgcacat 2478241 aatggacacc gtctaccttc tctctatcag cgagattcgg atctttaata gaaaacacag 2478301 tcacctcatg tttttttgca attaaagggg caaccgcttc gaggtagatt tgaatggcgc 2478361 ctcctcgaac cgatgggaca ggaagcttct ctgtggcgat cagtgctatt ttcatacata 2478421 gcctccattc ctgcatgatt tttaactagt tagaatcatg atacggctga acaaccaact 2478481 tgtgcggaat gggactgccc taaaaacaaa acgggtaaac aaccagattc atctattaaa 2478541 tatagtcaaa taactcaatc attttttcct tttgattcat aaggtaggag taaaacaggt 2478601 aaggatgtgt cctttaatgg cagaaaacca tgaagtcatt gaggagggga attcatcaga 2478661 gcttccttta tcagcagaag atgcaaaaaa attaacggag ctggctgaaa atgtgcttca 2478721 aggatgggat gtgcaggctg aaaaaataga cgtcattcag ggaaaccaga tggcgcttgt 2478781 ctggaaggtc cacacagact ccggcgcggt ttgtctaaaa cgaatacaca ggccagaaaa 2478841 gaaagcgttg ttttccattt tcgcgcagga ctatttagca aaaaaaggca tgaatgttcc 2478901 tggcatactc ccaaacaaaa aaggcagcct atattctaag cacggctcat ttctatttgt 2478961 cgtatatgac tggatcgaag gaagaccgtt tgagctgact gtaaagcagg acttggagtt 2479021 tatcatgaaa ggccttgctg attttcatac agcttccgtc ggatatcagc cgccaaatgg 2479081 cgttcccata tttaccaaat taggtcgctg gccgaatcac tacacgaaac gatgcaaaca 2479141 gatggaaacg tggaagctga tggcggaggc ggaaaaagaa gatcctttct cacagcttta 2479201 tcttcaggag atagatggct ttattgaaga cgggctgcgc atcaaagacc ggcttttgca 2479261 atcgacctat gttccatgga ctgaacagct gaaaaaaagc cctaaccttt gccaccagga 2479321 ttacggaacc gggaatacac tcttaggaga aaatgaacag atttgggtca tcgacttaga 2479381 taccgtatca tttgatctgc ctattcgcga tttgcgcaaa atgattattc cgcttttgga 2479441 tacgacgggt gtttgggatg acgaaacatt taatgtcatg ctgaacgcat acgaatccag 2479501 agccccatta actgaagaac aaaaacaagt catgtttatt gatatgctgt ttccttacga 2479561 gctttacgat gtcattcgcg aaaaatacgt ccgcaagtct gctttaccga aggaagaatt 2479621 agaatcagct tttgaatatg aacgcattaa agcaaacgca ttgcggcagc ttatttaaga 2479681 ccatcatttc ccccgcatat cgggggtttg atatttataa gataaagggt aattaaatac 2479741 atgcggaggt tgcaaatatg aaaaagattg tcggcgcttt agccgttttt gtgattacat 2479801 atgcgctgtt ttcagccgca ggctacctgt ttcctgtgga ccaagaatgg tacaattcat 2479861 tgaaaaaacc ggactggacg ccaagcggaa ctgcgatcgg catcatttgg gccatcctgt 2479921 ttgccctgat ctccctttca gcagccattg tatatgctgc gttttcattt aaaggtgcga 2479981 aaagcttttg gtttacactt ttgataaatt acgtgctcaa tcaagccttc agctatttcc 2480041 agtttacgca aaaaaatctg ctggctgcat cgcttgactg cctgcttgtc gccatcacag 2480101 caatcgtatt actgatcatt gccaaaaaat acagcagagc cgcaagctat cttcttttgc 2480161 cttatttttt atggagtgca tttgcgacgt tcttatcctt tacaatcaat tcaatgaatc 2480221 tgtgaacaaa aaaagccgct tatacagcgg ctttttcaca tcatcggctt gatgccccaa 2480281 atgtccttcg catattcccg gatcgtgcgg tcgctggaga aatatccaga atgagcaatg 2480341 tttacaatcg aatgctcaga ccatttcctt cgctctcgat aatcagcttg aattcgctcc 2480401 tgtgcatctg catatgagct gaaatccttc agcacaaaat actcatcatt atgcggaagc 2480461 agcgagtcaa agatcgattc aaattcatct gcctctcctt caaaaaaacc attgatcaac 2480521 tgatccgcta cctgcctgat tctcctgtca tgctgataat attccctcga cctatagccg 2480581 ccgttttcct gatacgatag aacctcatcc gcctttaagc cgaacgtgta aatacagtca 2480641 gggcccaccc gctcaaggat ctcgatattt gcgccgtcat gcgtgccgat cgtcaaagcc 2480701 ccgttcatca taaacttcat attccctgta ccagacgctt ccttgcttgc ggttgaaatt 2480761 tgctcactta cgtctgatgc cggaaaaatt cgctcagcca tagaaactct ataattttct 2480821 aaaaaaacaa ctttgatcag ctgtttgacc gccggatcat aattgacttt ttctgcgaca 2480881 gaatggatca gcttaatgat tttcttggca taataatagc ttggtgaagc ctttgccccg 2480941 aaaataaagg tttgcgggta gattgaaaac cccgaatcct ccttgaggcg gttatacaaa 2481001 tacataatgt gaagaacatt cagcagctgc cgtttatatg catgaagccg tttcacctgt 2481061 acgtcgaata tgctctcagg gttcacaacc accccggccg tgcaaaaaat caaatcggca 2481121 agctcttgtt ttttcttgct tttgttgttt tgaaactgtt caataaatgc aggatcagtg 2481181 gcgtacggtt ctaaacggat cagtgattcc ggctgcttga cccattcatc gccgatcgcc 2481241 tctgtaatga tggcagacaa gcctggattc gcttttaaca gccagcgcct gtgggcaatt 2481301 ccattcgtct tattgttaaa acgattcgga aacagcaagt gaaagtcgcg catctccctt 2481361 tcctttaata tatcggaatg tatttttgca acgccattta cactgtagct gcctactatg 2481421 gccagatgag ccattttgac aacaccatgc gctgtaatcg ccatgttctc tatccttttc 2481481 cagtctccag gatacttttc ccaaactgca cggcaaaacc tctcattgat ctcttcaata 2481541 atcatgtaca ttcgcgggag cagcggctta aacaaatgaa tcggccattt ctcgagcgct 2481601 tctgacaatg ttgtatgatt tgtataagaa atcgtatgta cagtgatatg ccaagcttct 2481661 tcccagctca tgttctcttc atcgagcaaa atccgcatta gctcaggcac cgcaagcgca 2481721 gggtgagtgt cattaatatg aatgctcact tttttatgca ggccggataa agatttatgt 2481781 gttttacggt aattgttcac aatgcttttt aagcttgcgc atactaaaaa atactgctgc 2481841 ttcagccgta aaattttccc ctcatcatgg gtgtcatcgg gatataagaa ttcagaaacc 2481901 gcttctgttt ctcgcttata agacaaaata ttaccgccgt gataatgggc atagggctcg 2481961 gcgttccaaa gccttaacgt gttgacagtg cccgtttcat agccgatgat cgggatatca 2482021 taaggaacag cggtaacaat tgtcgcttgt tcatggcgaa aatgcaggcg cccgcttttt 2482081 tctgtcatat ggacttcgcc ccaaaacggc acgtccactg cttgatccgc attccttact 2482141 tcccatacgt tcccgttttt cagccattgc tcaggcagct ccacctgatg tccgtctaca 2482201 attttttgct caaacaaacc atgcttataa cgtatgccca tgccgtgccc aggcaggttc 2482261 aacgaagcaa gcgaatctaa aaagcaagcg gccaagcgcc caagtccgcc attgccgaga 2482321 cctgcatcgt tctctatctg aaggatctcc tctaaattga tgccgatttc ctttaaacca 2482381 gcttctacaa catcacgaac accaagattc attaagtttt gctcaaggag ctgaccgagc 2482441 agaaattcga ttgataaata atatgtctgc ttcccggaat ttgatctgct tttttcattc 2482501 gtttcgatcc aatcagcgct gatatactct ctgaccatat tgcccaacgt tttatattga 2482561 tccagcttgg cagaatcttt aaagcttttt ccgcacgtca tttccagacg ctttaaaaat 2482621 aagtctgcaa agcgttcttt actcgagaac atcccgtcca ctccttgtca cctgctcgaa 2482681 aatacgctga tactctttag ccgacttccc ccagctgtaa tctgcattca tagcggtctt 2482741 cacgatgctc ttccatacat cctgttggca ataaaacgac agcgcccttt ctatcgtaaa 2482801 tttcagatca tgcgcattaa aggcggaaaa cgtaaagcca ttgcccgttc cctcttcctc 2482861 ctgataggca cggacagtgt cgtaaagacc gcccgtttcc ctgacaatcg gaatggcgcc 2482921 atattgaaga gcaatgagct gccccaaacc gcacggctca aatttcgacg gcatcaaaaa 2482981 catatcagag cccgcataaa tttgatgggc tagcggctca tcaaacccga tataagcccg 2483041 gcacttctca tgaaaagcaa attctgcata ccggaaataa tcttcaaatt cacgttctcc 2483101 tgtgcctagc acaaccagct gtatgtcttg ctcctcaaga agttcgtgca taattctgcg 2483161 gacaagatca agcccctttt gtttagtgag ccttgtcacc atactgatca gcggaatatc 2483221 gtttttctct ggaagcccca tccgctgctg aagcttcgtt ttgttttcca gcttgcatgc 2483281 aagatcccct gaatcgtatt gcgcctctat ataagggtcg cttttcggct gatagaacgt 2483341 atcatcaatg ccatttaata tgccggttac atcatcttcc ctatattgca aaacctgttc 2483401 caactgctca ccataatacg gcgtcatgat ttcatttctg taagtggggc tcacagttgt 2483461 cacatgatca gccgcaatga tgcccgcttt cataaaatta acaaatccgt tgcattctaa 2483521 cctttcataa tgaaaatgat ccatctcaag acccagcaag tcatgtgtga catcaggagg 2483581 gaatatgcct tgaaactgca ggttgtggat cgtgagcacg cttttcatcc gttcataaaa 2483641 aggatgtttt ctgtactcct ctttcagcaa ataattgacc atcgctgtat gccaatcgtg 2483701 agtatgaaca atatcggctt gaacattcac aactttggca gcctccagca cagctcttga 2483761 aaaaaaggca aaccgctcac cgtcatcata atgcccgtac aacgaatccc tgttgaaata 2483821 gtactcattg tcgatgaagt aataattcac atcattctct gccatatgtt caattccgca 2483881 atattgctgc cgccagccga cagctacggt acactcagcc tgttttttca tacgcttttt 2483941 ccacggttca ggtatttggc tgtacttcgg cagcatcaca gctacctcat tgcctaatcg 2484001 cgcaagcgcc tttggcagag cacctgctac atcggcaaga cctcctgatt tcacaaatgg 2484061 ggtgcattct gacacagcaa ataatatctt caagaattca tcagctctcc ttgcaccaaa 2484121 ccttttctta atacaagcgg ctgctcagct gttcctgcag cttccgtcgc cttgccgatt 2484181 ttaacatcct tatccgaaat gacctgctca agaagacaat cctctccaat ctgcgttttt 2484241 tgcataataa tgcagttttt cagcttcgta ccctttccga catggaccgc cctgaacaaa 2484301 atgcagtttt caacctctcc ttcaagcaca cagccgtttg ccaccaaaga atttttgaca 2484361 gtgctgtgct ttccgtattt cgtaggcggc tcatccttca cttttgtata gatcggctgc 2484421 tgcggcaaaa acacctgctg ccaaaaacga ggctgaatga gctccatact gtgggtataa 2484481 tatttttcca ccgaatcaat gacagcggca taacctgaat attcataagg gcaaatggtc 2484541 agggcggaag attccttttc aacagcctcc tgaatggttt tatagccttt ttcgctatgt 2484601 ccgtagatca gatcctttaa aagcgttgtt gacatgatat agatttgcag cgactggccg 2484661 tcctgaaata cctcggtgac gtcgcagcca acctcctgat ggcgtttcag cacatattga 2484721 aattgaatgt tgcatacggt atggctgttg gagattacag catattgctg agtgcttctg 2484781 tggaagtaat ctagatggtc cgaaaactgg cgaaaggaac cgaattcatc gtattcgtga 2484841 tgaagatggg gagacgggaa aaaaaagagg ccgtcctttt tccggtgcaa atcccattcc 2484901 ttacccgccc caaggtgatc catgagcgaa cggtaacgat acttcggaaa aattgcaaca 2484961 ctcctaatat ccgcattcac catgttggaa agcataaaat caatcagtcg gtacctgccg 2485021 gcaaaaggga tcgccccgag cgaccgctgt gctgttaaat cctgaagaga atgcttatat 2485081 gtggtttcat ctataacacc taacatttga ttattgaaca ctgactctgc cccctcttca 2485141 gtaattaaat caattctttt tctacaaatt cctctgaaac gagcagcacc tcttcaatgt 2485201 ctttttcgga gcgaatcact gcgccatccg gcagcaccat cccattagga acgatggcat 2485261 tttcaatgac tacatgctcc ccaatcgtca catccggcat tatgacggat gatgtaacag 2485321 tcgtatgctt accaacagtc acaccttgaa aaagaacgga gtgagacaca tttccatata 2485381 caacacaacc ttcgttcaca agcgaatctt gaacctgcgc atcagatgaa ataaattgcg 2485441 gaggctgatt tggattgacg gagtaaattt tccatttgcg ttcaaacagc ttcagctccg 2485501 agtcctcttt taacaaatcc atattggctt cccacaagct ctgcaccgtt ccgacatcct 2485561 tccaatatcc cttgaacgga taagcagaaa gcttcttttt ctcttccaaa agcagtggaa 2485621 taatgtcttt gccgaagtcg tggctagaat aagggttttg atcgtccatc tcaagatact 2485681 gtttcaaaag cggccaattg aatatataaa ttcccattga ggcaagattg ctcttaggga 2485741 atttgggctt ttcatcaaaa tgtgtgatcg tcccatctgg attggccttc atgatgccga 2485801 accggcttgc ttcctcccag cccacttcga tgacagagat ggtcacatct gctttctttt 2485861 caatgtgata atcaagcatt ttgccgtagt ccattttgta tatgtgatct cctgataaaa 2485921 tcagtacata ctcaggatca tactgattca aataattgag attttcataa atggagcttg 2485981 ccgtcccttt ataccatttg acttctgatg actcggcata agggggtaaa accgtcacgc 2486041 cgccattata tctatccagg tcccatgcac tgccgatccc aatataggaa ttcagctcga 2486101 gcggctgata ttgcgttaaa atcccgactg tgtctatgcc tgaattagaa cagttgctta 2486161 gggtaaaatc aataatcctg tattttcccc cgaaagatac agccggtttg gccatatttt 2486221 ttgttaatcc gctgagacgg ctgcccttcc cgccggcaag gagcatggct acacattgtt 2486281 ttttcatctt tttatctctc ctcttttttt aaccgcccgt aaaatcgaga tgccgtaagg 2486341 ggggatggtc atcgtgatat aacacggttt atgatgaagt gctccctttt tagccgataa 2486401 cggctttttg ttgatttgcc ctgagcctcc atatgtttca ctgtcactgt taagcacttc 2486461 aatgtattga gtaaaaaaag gaactccaac atcatattga tgatagacca cgggtgtaaa 2486521 attacaaatg atgacaagcg cctcaccgtg cttttggcca taacgaataa aagaaaagat 2486581 tgattgttcg tcattatgga catcaatcca ttcaaacgat tgtgcacgat ggtcatgctc 2486641 ataaaggatt ttgctttttt ggtaaaagcg gagaagatct tgcgtaaaaa cgctggcttt 2486701 ctgatgcatg gggaaggagt ccaaaaacca atcaagctgt tctgtatctt tccattcatc 2486761 aaattgagca aactctgatc ccataaagat caatttcttt ccgggatgca ctgtcatata 2486821 gcccagcaaa agccgatact gggcaaattt ctgccagtag tcgccaggca ttttattgag 2486881 aagtgatttt tttccgtata cgacttcatc atgagaaaac ggcaatacaa aatgttcact 2486941 aaacgcatat agtaatgaaa aagagataag ctgatgacaa tgccgccttt cttcgggcgg 2487001 cgtctccatg tatttcagta cgtcattcat ccatcccata ttccatttat aatgaaaacc 2487061 aagcccccct tcctcaacgg cacctgtcac ttgaggccat tctgtagaat cttctgcaat 2487121 catcatcaca tggggatatg cctctctcat ggtttgattg agttttttta aaaaatcaac 2487181 agcatatgga ttcgtgtggc gttcatcctg atttggccaa tacaagatat tagccactgc 2487241 atcaacccta aatccatcta tatgatagaa ttccgcccag tacaacgcat tcgaaattaa 2487301 aaaactatga acttccggtt tccccaggtc aaagtttgcc gtgccccata accagttctc 2487361 ccgatcacgt tcttctttgt attcataaag cggttctcca tcaaacatat aaaggccatg 2487421 tgcatcttta caaaaatgtc cggggaccca atccaaaatg actccgatat tttgttgatg 2487481 acattcatcc acaaacttca tcagatcatg cggcgggcca aacctgcttg tcgggctgta 2487541 ataccccgtt ccttggtacc cccatgaacg atcatatgga tgctcataca cgggaagcag 2487601 ttcaatatgg gtaaacccat gcttcttgat ataagggata agcgtctgac ttaattcttt 2487661 ataggaataa tgcctgccat cagaatgctt cttccaagac ccaagatgca gttcataaat 2487721 gaaaacaggt ttttcataca gcgtcttagc cttctgtttc ttttgccatt tttgatcttg 2487781 ccagctgtat ccttccaaat cgtaagtaag tgacgctgtg tttggtctga cttctgaata 2487841 aatagcgtat ggatctgcct tcagcctgat ctcaccgtta ttcgtcacaa tttcgtattt 2487901 atatcgttcc ttttctccta tacctggaat aaataacgtc caaatgccat tatcattcac 2487961 tctgtgcatc acatgctctt ctccagacca gctgttaaaa tctccagcca ctcgtacttc 2488021 cgacgcatga ggcgcccaca cacagaattc atatccgctt ttgccattca gctcgcggta 2488081 atgcgagcca aacagctgat agcttttaaa cagactgcct tcgtgaaaaa gataaacatc 2488141 atgtgctgtc gggctggcag cggccatgta atcatccttt ctgacatcat agttttcatt 2488201 tatagtattt attcgaagaa ataaaaaaaa gccctttcct gaaagcgctt atacttatag 2488261 acaattaact tcattttctg aagaaaaacg aaatatatgg agatttttgt agtctgtttt 2488321 taaaataaag aacaaaatct aagacatatc atgatttata aaaacaaaaa aaccttgcag 2488381 gatatgcaag gcttctggat gacccgtacg ggattcgaac ccgtgttacc gccgtgaaag 2488441 ggcggtgtct taaccgcttg accaacgggc cgataattat gatatctgta atcatatggc 2488501 ggagaaggag ggatttgaac cctcgcgccg cttacacgac ctacaccctt agcaggggcg 2488561 cctcttcagc cacttgagta cttctccatt tggctccaca ggcaggattc gaacctgcga 2488621 ccgatcggtt aacagccgat agctctacca ctgagctact gtggaacaaa agtcatggtg 2488681 ggcctgaatg gactcgaacc atcgacctca cgcttatcag gcgtgcgctc taaccagctg 2488741 agctacaggc ccatgacgat atagaaatgg agcgggtgat gggaatcgaa cccacgacat 2488801 cagcttggaa ggctgaggtt ttaccactaa actacacccg caatttttat ttggggcgat 2488861 tgatgggaat cgaacccacg aatgccagag ccacaatctg gtgcgttaac cacttcgcca 2488921 caaccgccaa agcatattga taaatggtgg ctcgggacgg aatcgaaccg ccgacacacg 2488981 gattttcagt ccgttgctct accaactgag ctaccgagcc taagtattta aatggcggtc 2489041 cggacgggac tcgaacccgc gacctcctgc gtgacaggca ggcattctaa ccaactgaac 2489101 taccggacca ttttaaaatt tggttgcggg ggcaggattt gaacctgcga ccttcgggtt 2489161 atgagcccga cgagctaccg aactgctcca ccccgcgatg attaggaata tgtatggcgg 2489221 aggaagaggg attcgaaccc ccgcgggctt tgacacccct gtcggttttc aagaccgatc 2489281 ccttcagcca gacttgggta ttcctccgta tagtggtgga ccttgtagga ctcgaaccta 2489341 cgaccggacg gttatgagcc gtctgctcta accaactgag ctaaaggtcc attggtagcg 2489401 gcggagggga tcgaaccccc gacctcacgg gtatgaaccg tacgctctag ccagctgagc 2489461 tacaccgcca aatatttttg aaatcaagtg gagcctagcg ggatcgaacc gctgacctcc 2489521 tgcgtgcaaa gcaggcgctc tcccagctga gctaaggccc caagaatggt cgggaagaca 2489581 ggattcgaac ctgcgacccc atggtcccaa accatgtgct ctaccaagct gagctacttc 2489641 ccgatttcat atagatcatg gcgcgcccga gaggagtcga acccctaacc ttttgatccg 2489701 tagtcaaacg ctctatccaa ttgagctacg ggcgcaaaac ttaatgccga gggccggact 2489761 tgaaccggca cggtagtcac ctaccgcagg attttaagtc ctgtgtgtct gccaattcca 2489821 ccaccccggc gtggatggta tagttggagc ggaagacggg attcgaaccc gcgaccccca 2489881 ccttggcaag gtggtgttct accactgaac tacttccgca gaaatggtgc ggatgaaggg 2489941 acttgaaccc ccacgtctgt aaagacacta gagcctgatt ctagcgcgtc tgccaattcc 2490001 gccacatccg caacatgtaa atggtgagcc atgaaggact cgaaccttcg accctctgat 2490061 taaaagtcag atgctctacc aactgagcta atggctcttc ttacaataga cttgaatatt 2490121 atatcatata aaagtggtgc cggcaagagg acttgaaccc ccaacctact gattacaagt 2490181 cagttgctct accaattgag ctacaccggc atatatgtaa aaccgatatg tataatgaaa 2490241 aatggtggag gatgacgggc tcgaaccgcc gaccctctgc ttgtaaggca gatgctctcc 2490301 cagctgagct aatcctccat acttgcacta acgtgcaatt gcttggcggc gtcctactct 2490361 cacaggggga aacccccgac taccatcggc gctgaagagc ttaacttccg tgttcggtat 2490421 gggaacgggt gtgacctctt cgctatcgcc accaaacaaa ttgagagtgt tctctcaaaa 2490481 ctagataaca ggtgtgacat cattcaaaaa tatggttaag tcctcgatcg attagtatct 2490541 gtcagctcca tgtgttgcca cacttccacc tcagacctat caacctgatc atctttcagg 2490601 gatcttactt ccttgcggaa tgggaaatct catcttgagg ggggcttcat gcttagatgc 2490661 tttcagcact tatcccgtcc gcacatagct acccagcgat gcccttggca gaacaactgg 2490721 tacaccagcg gtgcgtccat cccggtcctc tcgtactaag gacagctcct ctcaaatttc 2490781 ctgcgcccgc gacggatagg gaccgaactg tctcacgacg ttctgaaccc agctcgcgta 2490841 ccgctttaat gggcgaacag cccaaccctt gggaccgact acagccccag gatgcgatga 2490901 gccgacatcg aggtgccaaa cctccccgtc gatgtggact cttgggggag ataagcctgt 2490961 tatccccggg gtagctttta tccgttgagc gatggccctt ccatgcggaa ccaccggatc 2491021 actaagcccg actttcgtcc ctgctcgact tgtaggtctc gcagtcaagc tcccttgtgc 2491081 ctttacactc tgcgaatgat ttccaaccat tctgagggaa cctttgggcg cctccgttac 2491141 cttttaggag gcgaccgccc cagtcaaact gcccacctga cactgtctcc ccgcccgata 2491201 agggcggcgg gttagaaggt caatacagcc agggtagtat cccaccgatg cctccaccga 2491261 agctggcgct ccggtttcca aggctcctac ctatcctgta caagctgtac caacattcaa 2491321 tatcaggctg cagtaaagct ccacggggtc tttccgtcct gtcgcgggta acctgcatct 2491381 tcacaggtac tataatttca ccgagtctct cgttgagaca gtgcccagat cgttgcgcct 2491441 ttcgtgcggg tcggaactta cccgacaagg aatttcgcta ccttaggacc gttatagtta 2491501 cggccgccgt ttactggggc ttcaattcgc accttcgctt acgctaagcg ctcctcttaa 2491561 ccttccagca ccgggcaggc gtcagcccct atacttcgcc ttacggcttc gcagagacct 2491621 gtgtttttgc taaacagtcg cctgggccta ttcactgcgg ctctctcggg cttgcaccct 2491681 aacagagcac cccttctccc gaagttacgg ggtcattttg ccgagttcct taacgagagt 2491741 tctctcgatc accttaggat tctctcctcg cctacctgtg tcggtttgcg gtacgggcac 2491801 ctctcacctc gctagaggct tttcttggca gtgtggaatc aggaacttcg ctactatatt 2491861 tcgctcgcca tcacagctca gccttatggg aaacggattt gcctatttcc cagcctaact 2491921 gcttggacgc ggatatccaa taccgcgctt accctatcct cctgcgtccc cccattgctc 2491981 aaatggtgag gaggtggtac aggaatatca acctgttgtc catcgcctac gcctttcggc 2492041 ctcggcttag gtcccgacta accctgagcg gacgagcctt cctcaggaaa ccttaggcat 2492101 tcggtggagg ggattctcac ccctctttcg ctactcatac cggcattctc acttctaagc 2492161 gctccaccag tccttccggt ctggcttcac agcccttaga acgctctcct accactgttc 2492221 gaagaacagt ccgcagcttc ggtgatacgt ttagccccgg tacattttcg gcgcagagtc 2492281 actcgaccag tgagctatta cgcactcttt aaatggtggc tgcttctaag ccaacatcct 2492341 ggttgtctaa gcaactccac atccttttcc acttaacgta tactttggga ccttagctgg 2492401 cggtctgggc tgtttccctt tcgactacgg atcttatcac tcgcagtctg actcccaagg 2492461 ataagtcatt ggcattcgga gtttgactga attcggtaac ccggtagggg cccctagtcc 2492521 aatcagtgct ctacctccaa gactcttacc ttgaggctag ccctaaagct atttcggaga 2492581 gaaccagcta tctccaggtt cgattggcat ttcaccccta cccacacctc atccccgcac 2492641 ttttcaacgt gcgtgggttc gggcctccat tcagtgttac ctgaacttca ccctggacat 2492701 gggtagatca cctggtttcg ggtctacgac cacgtactca tgcgccctat tcagactcgc 2492761 tttcgctgcg gctccgcatc ttctgcttaa ccttgcacgg gatcgtaact cgccggttca 2492821 ttctacaaaa ggcacgccat cacccgttaa cgggctctga ctacttgtag gcacacggtt 2492881 tcaggatctc tttcactccc cttccggggt gcttttcacc tttccctcac ggtactggtt 2492941 cactatcggt cactagggag tatttagcct tgggagatgg tcctcccgga ttccgacgga 2493001 atttcacgtg ttccgccgta ctcaggatcc actcaggaga gaacgaagtt ttgactacag 2493061 ggctgttacc tcctatggcg ggcctttcca gacctcttca tctacctcgt tcttttgtaa 2493121 ctccgtacag agtgtcctac aaccccaaga ggcaagcctc ttggtttggg ctgatcccgt 2493181 ttcgctcgcc gctactcagg gaatcgcatt tgctttctct tcctccgggt acttagatgt 2493241 ttcagttccc cgggtctgcc ttctcatatc ctatgaattc agatatggat accactccat 2493301 tacgagtggt gggtttcccc attcggaaat ctccggatca aagcttgctt acagctcccc 2493361 gaagcatatc ggtgttcgtc ccgtccttca tcggctccta gtgccaaggc atccaccgtg 2493421 cgccctttct aacttaaccg ttaaaaagaa tcactatgtg atatcttgtg ttactaattg 2493481 aatgtgatgt ctactgttat ctagttttca aagaacacgt ttcgaaggaa tgatccttca 2493541 aaactaaaca agacagggaa cgttctgttt ataagacctt gggtcttata ttccgtataa 2493601 tatccttaga aaggaggtga tccagccgca ccttccgata cggctacctt gttacgactt 2493661 caccccaatc atctgtccca ccttcggcgg ctggctccta aaaggttacc tcaccgactt 2493721 cgggtgttac aaactctcgt ggtgtgacgg gcggtgtgta caaggcccgg gaacgtattc 2493781 accgcggcat gctgatccgc gattactagc gattccagct tcacgcagtc gagttgcaga 2493841 ctgcgatccg aactgagaac agatttgtgg gattggctta acctcgcggt ttcgctgccc 2493901 tttgttctgt ccattgtagc acgtgtgtag cccaggtcat aaggggcatg atgatttgac 2493961 gtcatcccca ccttcctccg gtttgtcacc ggcagtcacc ttagagtgcc caactgaatg 2494021 ctggcaacta agatcaaggg ttgcgctcgt tgcgggactt aacccaacat ctcacgacac 2494081 gagctgacga caaccatgca ccacctgtca ctctgccccc gaaggggacg tcctatctct 2494141 aggattgtca gaggatgtca agacctggta aggttcttcg cgttgcttcg aattaaacca 2494201 catgctccac cgcttgtgcg ggcccccgtc aattcctttg agtttcagtc ttgcgaccgt 2494261 actccccagg cggagtgctt aatgcgttag ctgcagcact aaggggcgga aaccccctaa 2494321 cacttagcac tcatcgttta cggcgtggac taccagggta tctaatcctg ttcgctcccc 2494381 acgctttcgc tcctcagcgt cagttacaga ccagagagtc gccttcgcca ctggtgttcc 2494441 tccacatctc tacgcatttc accgctacac gtggaattcc actctcctct tctgcactca 2494501 agttccccag tttccaatga ccctccccgg ttgagccggg ggctttcaca tcagacttaa 2494561 gaaaccgcct gcgagccctt tacgcccaat aattccggaa aacgcttgcc acctacgtat 2494621 taccgcggct gctggcacgt agttagccgt ggctttctgg ttaggtaccg tcaaggtacc 2494681 gccctgttcg aacggtactt gttcttccct aacaacagag ctttacgatc cgaaaacctt 2494741 catcactcac gcggcgttgc tccgtcagac tttcgtccat tgcggaagat tccctactgc 2494801 tgcctcccgt aggagtctgg gccgtgtctc agtcccagtg tggccgatca ccctctcagg 2494861 tcggctacgc atcgttgcct tggtgagccg ttacctcacc aactagctaa tgcgccgcgg 2494921 gtccatctgt aagtggtagc cgaagccacc ttttatgttt gaaccatgcg gttcaaacaa 2494981 ccatccggta ttagccccgg tttcccggag ttatcccagt cttacaggca ggttacccac 2495041 gtgttactca cccgtccgcc gctaacatca gggagcaagc tcccacctgt ccgctcgact 2495101 tgcatgtatt aggcacgccg ccagcgttcg tcctgagcca ggatcaaact ctccgataaa 2495161 tggatcacag gttaagttca ccgcatcctg cggcgacacc tgtgtgacct gcgtcgtgca 2495221 ggccctagtt tgactgacta cgcacatcgc agtgcgattt ttaaaaactg aattaacagg 2495281 tacgttttgt cttgtttagt tttcaaagat catttcgtta cttctcaatg aagcagcttt 2495341 actaatataa cattcagctt cttttttgtc aacaactttt ttcaagttgt tttgaagcat 2495401 ctagtttgtg tccgctgtgc atcagcgacg tttaataata taacacctgt atttatttat 2495461 tgcaatagtt ttttaaaaaa aatctataaa acaaataaac tataatcctc gccatgattt 2495521 ctaaagcgtg tgtatcatat aagtttctta aaagaacata tacatcagtc atgtgatctt 2495581 gttgtttttt tcgttttctt gtatagtaga aacgaactaa atactgatga ccacaagggg 2495641 agcattaaag ctgagagtga gcggtttcgt tctgaccctt tgaacctgtt agttaacgct 2495701 ggcgtaggga tgtggcaaag tcaaatgaat tgcagatcgt aaagcagtgc gtggaacttt 2495761 tctcatcctt ccgcgtgctg cttttttgtt gtccttttgg ttgtctgtca atggaaggag 2495821 atagatatga atcaatctaa gcaactggtt cgccttattg aaattgccat tatgacagcg 2495881 gcagccgtta ttttagacat tgtctcagga atgtttctta gcatgcctca aggaggctcg 2495941 gtctccatca tgatgattcc gatcttttta atttcgtttc gctggggtgt caaagcaggt 2496001 cttactacag gtttgttgac aggtctagta caaatagcaa tcggaaactt gtttgctcaa 2496061 catcctgtac agctattgtt agattacatt gtcgctttcg cagcaatcgg cataagcggc 2496121 tgtttcgctt cttctgtccg taaagccgct gtatcaaaaa caaaagggaa attgattgtt 2496181 tcagtggtca gcgcagtttt tatcggcagt ttgctgcgct atgccgcgca tgtcatttca 2496241 ggagctgtgt ttttcggcag ctttgctcca aaaggaacac cggtatggat ttattcttta 2496301 acttataatg cgacttacat ggttccttca ttcattattt gtgcaattgt cctatgttta 2496361 ttatttatga cagcaccccg tctgcttaaa agtgacaaag cgtaaaagta acaatccccc 2496421 agcgaattcc gctgggggat ttttcgttat ctgttaagaa gtgtttttaa agctgaaaga 2496481 tccggccagc caagacctac ttctttcagc cttactccgg caatttcaaa gttgtcctcc 2496541 gctactcttt caggtgaata ggcctgataa aatataatcg agggattctg ctcaataacc 2496601 caaacaaaca tacttgaaaa accatgttga agcaaaaact ccgctccttt tgctaagagc 2496661 gccctgcctg caccttgccg ctggcgctct tccagaagat aaatagcgta taactcgccg 2496721 tcatagcctt cttgttcaga gcgaataggt ccaaatgaag caaagccgaa tactgaaccc 2496781 ttttcgtcct gagcaacaaa tactcccttt aacgagcgac ttttccattt gtcttcaaat 2496841 tccttatagt tcaggctgtt taaataatca atcgggataa tttcgtggta tgttgtcctc 2496901 cagctgtcta catgcacttt tgcaatgtcc tttatatcct ctaacttcgc ttcacgtaca 2496961 gttaccatac ggttctgccc tttccttact ctgatttttg gatcgttttg gcttctttga 2497021 tttcatttgt taattcatta atgctttgtt ttacgtttcc ttttcctgaa aagttctcaa 2497081 gcatttcttt tacatcaatt cctgaggatg cttttaaact ttcttgcaga cttgacatta 2497141 agttcgtcgc atagctggtt actttgtttg ctccgcttga ttcaccgctt cctcctgtat 2497201 cgacaacggt gattttatca atatttgaaa gaggtgccgc tgcttgtttc gcgtattccg 2497261 gaagcatttt gacaatcata tcgaaaatcg ccgcctgccc gtactgttca aaggcggccg 2497321 caattttctc ttttgcttcc gcttctgcaa gacctttcag gcggataacc tctgcttctg 2497381 tctctccttt cgctttttcc gcttctgctt ttgctagccc gtcaattctt actttttccg 2497441 cctcagcctt tgccattgct tcaatactgt acttcttggc atcggcttcc gcgagctgtt 2497501 tggctttctc agctgctgcg gactgctcaa cagaataacg gtctgcatcg gcttttttct 2497561 ttacctctga gtcgtattga cgttcacggc gaagaatttc tttttcttct agttctattt 2497621 gtttttggcg ttcgataatt ttaacctgca tttcctgctc tgtgacttgc tggcgcgctc 2497681 gggcagtctc taaatcatat gcttggtcgg cattcgcttt tgccgtatct tgttctctgc 2497741 ggaattcagc cattttgagc tgattgattt tttcagcttc agcgatttcc gtcgcccgtt 2497801 caagttctga tttttttgcg tctttatcgg cttctgcccg cttaattcgg gtttctttat 2497861 cagcctctgc tgttgcgata tcagcatcgc gttttacttg ggcaattctc ggtttcccta 2497921 atgattcaag ataaccgttt ttatcacgaa catctttaat ggtaaacgag acgattacaa 2497981 gtcccatttt cgcgagatcc tgtgaagcga cacgctgcac ctcttgagag aatttttctc 2498041 tgtttttata gatttcttct actgtcattg agccgagaat ggaacgaagg tggccttcta 2498101 aaacctcccg cgcttcctgc tcacggtcgt cttttgattt ccctaaaaat tgttcggccg 2498161 ctgtagcgat ttctcctata gaaccgccga ttttaataat cgcagttcca tcggccatta 2498221 ctggcactcc ttgttctgta tagacttcag gtgtcgaaac atcgagtttg cttgataata 2498281 ggcttagcgg ctctgcctgc tggaagacgg gaaggacaaa ggttcctccg ccgcggacga 2498341 ttttaatacg gttgccgcct tcatcgacat gaacattttt attacccaga tagctccctg 2498401 ttacaattaa cgcttcatca ggccctgctg tacgatactt cgtaataaac acagctatta 2498461 gtgcaattaa taaaaagaat acaactccga tgatcattat aatcggcatt gtcatatcaa 2498521 attcctcctt ttatgttaaa tgggttcatg cggagtaacc gaaagaactc cgttgttaat 2498581 atctacgact aacaccgttg tcccgtaact gatctgctga ttatcaaaac tgaccgctga 2498641 ctttgaaatg gtcccgccta tcccttctat gaccacttca ccaaacccgt caaccggcac 2498701 agctgtaatc actttaccga gtcttcctct gagatcatct tctctatatg ccaatgattc 2498761 ttctgcagat gataatggca ccagtacaaa gatgtgaagc aataccacca gcatgatcga 2498821 aaggatgcaa gataaaagcg caatcagcaa gcttgacaga ggcaatacaa gttcacctat 2498881 atatccgccc gctgaaaaac atgtaaaaaa tgagagcact aatgtcggat taagaaacgg 2498941 aatgccttct gacagccctg aaaatacatc tccgaaaaac aggaataaca gcgtaaggct 2499001 gcccgcaata ataagcgtat aaagatacat tgtttgtata ggtactccaa ataactccaa 2499061 cttcctcatc ctttcttcat caatgcattg atgaacggct gccgttacca tttatacgag 2499121 acacctcggg aaaagtttca aaattttaag acaaataacc catttgaagt gctttataaa 2499181 tgataattgc ttatatatat ggtaatgtca ttttaggagg agatatgatg agtatcttta 2499241 atgaagccag attagaaacg tggaacgaat tgaaaggact ttctgacgaa aagctgaatc 2499301 aaaagccttc tgctgaagaa tggagcatac gggaagttct tgaccatttg aaaaaaatcg 2499361 atatgaccgc acaaaaaatg ttgaaggaac gtgtaaagga cgctccgatt aaagaaattg 2499421 aagaaaaacc gcttgaagta gcacaggaca gaaataataa acggaaagcc ccgagtcatc 2499481 ttgagcctgc gcatgatttt atttcaggca gccaaatgaa acgtgagctt gatgtggtaa 2499541 gagagcagct gactgctgcg attgcctctc tgaaagaaga agattttgaa agagtgcttc 2499601 cgcatcctgt gtttcaagag ctgactgtca gacagtggat cgattttatc ggccatcatg 2499661 aaaaacggca cctcagccaa atgaaagaaa ttaaagaaaa gatagaaagg gcctgattta 2499721 atcagaccct ttctgctttt cgtttgactt ttcgctgata ggaatgaact tctatttcat 2499781 cacctgtgta aacagcacca ggtctctcca caatacagac aatccctcta atgcccagtg 2499841 cgtggcggac gaaagccgac gccagcttcg gttggtccgg ataataagac tgaatgactt 2499901 ctcccggctg gatacacgga tcattttcgc cctcacacag cagagccgct ccgctcggaa 2499961 aaataatccg gcttccttct tttaatgaag taagatctgg cataccgctg actgccacat 2500021 tcgccccgag ccattccggc aaaattctcg gcactcccat ttttaaagcg atttcgttgc 2500081 attcctctat tgaaacaatt gaaatttgtc tgcggttgaa aatttcagtc cctcttgaaa 2500141 acattggttc tctggctccc gcttttttgg tcaggccaaa atgcaagtcg ccggggatgc 2500201 cgccataatc aaaatcaagc ttgtccattt gctttgttac gaagcttttt gtatctgcga 2500261 tatataagcc ttccgctttt gcagtcatac gcttccacat cagctggcac cttccttctt 2500321 atctaaaatt tccacctatg cttcattatc ccaaaaaatc ccgctctgta aaggagcggg 2500381 attttgatta taccgtttta ggcgtaaggt taaagcagcg tttgtagatc cagttgtatg 2500441 ctttttcatt taaatctcta gggtttccga aggtttgcgg atctttcatt gcttctttag 2500501 acaagcgttc gatcatatca ggtgatactc cctgctcttc taaagtcggc acttctaaat 2500561 cttcgaccag atcatacatc caattgacag atgctttcgc agcttcttct gttgtcatct 2500621 tgcttgtatc aataccgaac gctttcgcaa tacgcgcaaa cttctcagga tagcccttcc 2500681 agttgtattc catgacaggg cccatcatcg ccgctacaca ttggccgtga gcgactggga 2500741 taataccgcc aagcgtttgg ctcatcgcat gagcagcgcc cgctgattca cttccgtaag 2500801 aaagaccggc aagcatcgca gcctgcgcca ttccgtacct tgcttccaga tcctctccat 2500861 cagcaaatgc cctcttgatg taatgagcgg catactcaat cgccattaag gcaaccgcat 2500921 ccgtgattgg ctgtgcaaat ttcattgtat agcactcaat ggcatgggcg agcgcatcaa 2500981 ttcccgtcat agctgttaca tgcggaggca ttgaaacatg aagctcagga tcaatgattg 2501041 tcaagtgcgc tgcaatcagc ggaccgcccg tgttgaattt gaattctctt tcttcatctg 2501101 tgataaccgc ccattgggtt acttctgatc cggttccagc tgtagtggga attgtcgtca 2501161 gcggaggaat gcggttttcc agcggttttt tcccatctgc cgcttcataa tcaagcacgc 2501221 ttccttcgtg agtcgcttct actccgattg cttttgctgt atccatggag cttccgcctc 2501281 cgactgccac caaaccatta cagttctctt ttttgtaaag ctcagatcct tcattcacca 2501341 gacggacagg cgggtttggc tcaactttat taaagagtac cacttcaatg cctgcttctt 2501401 taagtgattc gattacggga tcagcaacac cggctttata aatcccaggg tctgtgacaa 2501461 ggagcgcttt tgaaacgccc agtgcagcta cttcctcacc cgtatgcttg atggctccga 2501521 ttccatgctt aatcacagtc ggaatttcaa atgtgtggaa tttctgcatg ctttctacct 2501581 tcatatttaa tgtcatcatc aatctccccc tcttatgaat taaaccagtt aaccgctgcc 2501641 ggttttgtat tgcggtatac atgtttgact tctgtgtatt cttcaaggcc tatttttcca 2501701 agctcgcgtc cgaacccgga ttgcttatat ccgccccatg gcgcttgtgc aaagtacgga 2501761 tgaaaatcgt tgatccaaac ggttcccatt ctcaagcggg ctgctacccg ttcgcacttt 2501821 tcaatgtctt ttgaccatac cgctccagcc aagccataga tggtatcatt cgcaagctcg 2501881 attacctctt cttcagagct gaaggtttcg actgtcaata caggaccgaa aacctcttcc 2501941 tgaacgattc tcatgtcaga attacagttt gagaaaatag taggttcata gaaaaagccg 2502001 ttttgaagct caggatcttc cgggcgtttg cctcctgtct ccagcttcgc gccttcctct 2502061 attccgatct ctacatattt ttctaccttt gccctgtgct ccgccgaaat aagcggaccg 2502121 ctttctgtct cagcatgaaa accgtttccg agttttatgc gttttgcccg tttgaccagc 2502181 tccgccaaaa attgatcatg aatggcatcc tcaacaagca agcgggaacc tgcagagcat 2502241 acttggccgg cgtggaaaaa tacagcgttt aaggcctgat caaccgcaac ttctaaatcc 2502301 gcgtccttga aaacaatatt tgggtttttc ccgccaagtt caagggcgat ttttttgacg 2502361 tttccgcttg ccgcccgcat gatttttttg cctgtttcaa ttccgcccgt aaatgaaatc 2502421 aaatcgacgt ctttgtttac ggcaagctcg tcgcccactg tggctcccgg tccaagaaca 2502481 agatttgcga caccttttgg aacaccggct tcttccatca gcttaaagac tttgattgtc 2502541 gtcagcggcg taatctcact cggcttcatg acgattgtgt ttcctgcggc cagtgcaggg 2502601 gcgattttcc agctcgcttg aaggagcgga taattccatg gagtgatctg gccgcaaacc 2502661 ccgattggct ccctaataat tttgctttct gaatcaggaa tcggagatga aatgatctct 2502721 ccgccatctt tgtctgccaa gccggcgtaa tattgaaaaa cattggcgat atcgtccata 2502781 tcggccttgc tttcttcgag tgtttttcct gtatcaagag attcaagctc agccagctcc 2502841 tcaagatcgc gtctgattaa ttccgcaatt ttcagaacaa tttttccgcg ttcaagcccg 2502901 gatagcgatg accattctcc tttgtcaaat gctctacgtg cggctgcgat tgctttgatg 2502961 gcgtcctctc gccctccctc gcttacagtt gcaatttctt cttgattaaa tgggttgata 2503021 atactgcgga tctgttcttt ttcggcactg atccattctc cgtcaatgaa taatgtttga 2503081 ctcatataag cctccttgac gtaaataaag tttgttaaat aaaaatttaa tgtttttaac 2503141 aaccttaatc taacatatgg tttttaaact gtcaaagtcc cattttgatt tttctttttg 2503201 acttttcctc atgtttcgtt aagataaaga acataaagaa ataacttaac gaatttaatt 2503261 ttctaaagga aaagagggtc agtatggatg aaaatccaga atttgcagct atagaacagg 2503321 ctcgggatct tgttattgac tccattgctg aaacgatgga tctttacgga attacccgca 2503381 gtgtcgggat tttatatggg acgatgtata tgagggatga gatgacgctt gacgaaatgc 2503441 gtgaggagtt gcaaatgagc aaaccaagca tgagcactgg cgtcaaaaag cttcaagact 2503501 taaatgtagt gaaaaaaaca tttcaccggg gcatccgcaa gcatacattt gtggctgaga 2503561 aggatttctt taaatttttc acaaatttct ttccacctaa atgggagcgg gaggttcaag 2503621 tgaatgtaac agcgatcgag gaagctcaag ctgatttaca aaaggtttta tgcaaggaag 2503681 atctcgatga ggatatcaaa aatgaagcac tgcagttata tgatcagctg gaaagctcta 2503741 aagcttacta tgactggctg aaacggcttg ctgaatcggt gcagaccgga gaaattttta 2503801 aatttatacc ggtcgaaaca aagtaaagca gaaaacgcct gggaaactag gcgttttttt 2503861 gatgtaacta ctacaaattt gaaaaatacg ggaaaaacac cccatttact tccaaaatat 2503921 ttgatggtaa ttttatgtag gtaaaatttg tatttggcct ttcagaggag gtgaaaagcg 2503981 ggcaggcctg tttaatttat cattttttag ggggaatttt gttatgaaac gcaaattatt 2504041 atcttctttg gcaattagtg cattaagtct cgggttactc gtttctgcac ctacagcttc 2504101 tttcgcggct gaatctacat caactaaagc tcatactgaa tccactatga gaacacagtc 2504161 tacagcttca ttgttcgcaa caatcactgg cgccagcaaa acggaatggt ctttctcaga 2504221 tatcgaattg acttaccgtc caaacacgct tctcagcctt ggcgttatgg agtttacatt 2504281 gccaagcgga tttactgcaa acacgaaaga cacattgaac ggaaatgcct tgcgtacaac 2504341 acagatcctc aataacggga aaacagtaag agttcctttg gcacttgatt tgttaggagc 2504401 tggcgaattc aaattaaaac tgaataacaa aacacttcct gccgctggta catatacttt 2504461 ccgtgcggag aataaatcat taagcatcgg aaataaattt tacgcagaag ccagcattga 2504521 cgtggctaag cgcagcactc ctccgactca gccttgcggt tgcaactaat gtaaaagacc 2504581 ggttaacgcc ggtctttttt gcgttttacc ctcccctttt tctctaatcc ccgttatctt 2504641 ttttctggtt taaaatttaa attgacaaac actagaaaca ggagtaaatt cttgagtgtt 2504701 caatttcata cagtctcttt taccgcttaa tcaaacacga acgggggaac caacgattgg 2504761 ctgttttatt aacagccttg gggtgaatct tactaagtaa gagggggtac tctgaatccc 2504821 taatccgaca gctaacctcg taggcgtata cagagaggag gtctattatc ggccattctt 2504881 tgcaatggtc ttttttgttt caaaaacgtt aattcactaa gggagatatg aacattggga 2504941 agaattaaaa ataagcaatt tgccgtgatc gggctgggcc ggtttggcgg cagcatttgt 2505001 aaagaacttc atagaatggg gcatgaggtc cttgcggttg atatcaacga agaaaaggtc 2505061 aatgcatatg cttcttacgc cactcatgcg gtaattgcca acgccaccga agaaaacgaa 2505121 ttgctttcat taggaatacg caattttgaa tatgtgattg ttgccatcgg agcaaatatt 2505181 caagcgagta cgctgaccac cctattatta aaggagcttg atattccaaa tatttgggtg 2505241 aaggctcaaa actattatca tcacaaggtg cttgaaaaaa taggcgctga ccgcattatt 2505301 catcctgaaa aagatatggg ggttaaaatc gcacaaagcc tttcagacga aaatgttttg 2505361 aattacattg atctatctga tgaatacagt attgtcgagc tgctggctac gcgcaagctt 2505421 gattcaaaat cgattattga cctgaatgta agagcaaagt acggctgcac gatcctggcc 2505481 attaaacatc atggagatat ctgtctttcc cccgcgcctg aagacatcat tcgcgagcaa 2505541 gattgcctgg tgatcatggg ccacaaaaag gatattaaac gttttgaaaa cgaagggatg 2505601 tagacaaagg tgacacttca aaaggataaa gtgatcaaat gggttcggtt tacaccgcct 2505661 caagtgcttg ccattggttt tttccttacc attatcatcg gggctgtcct attaatgctt 2505721 ccgatttcca ctacgaagcc attgtcatgg atagatgccc tttttactgc ggcttccgct 2505781 acaactgtta cagggcttgc tgttgtcgat accggcactc aatttacggt attcgggcaa 2505841 acagtaatta tggggctgat tcagattggc gggcttggat ttatgacatt tgcggtcttg 2505901 atcgtcatga tattaggaaa aaaaatcggc ttaaaagaac gaatgctcgt ccaggaagcc 2505961 ttaaaccagc cgacaatcgg cggtgtcatt ggccttgtca aagtcctgtt tctgttttcg 2506021 atcagtattg aattgatagc agcactcatt ttatccatcc ggcttgtacc tcaatacggc 2506081 tggtcatccg gcttgtttgc aagtttgttt cacgcaatat ctgcttttaa caatgccggg 2506141 ttttcgttgt ggcctgataa tttgatgagc tacgttggcg atcctacagt gaacctcgtg 2506201 attactttct tatttattac aggagggatc ggatttacgg ttctgtttga tgtgatgaaa 2506261 aatcggcgtt ttaaaacttt ttctttacat acaaagctca tgcttacagg aacgctgatg 2506321 ttgaatgcga tcgctatgct tacggtcttt attttagaat acagcaaccc cggcacgctc 2506381 ggccacctgc atatagtgga taaactgtgg gcctcctatt ttcaggcagt gacgccgaga 2506441 accgcagggt tcaattctct agattttgga agcatgagag aaggaacaat tgtatttact 2506501 ttattattga tgtttatcgg agcaggaagc gcatcaacgg cgagcggcat taagctgact 2506561 acgttcatcg tgattttaac atctgttatt gcttacttga gaggtaaaaa agaaacggtt 2506621 attttccgcc gttccatcaa atatccgatt atcattaaag ctttagctgt gagcgtcacc 2506681 agtttgttca tcgtgttttt agggattttc gccctgacga tcacagaaca agcgccattt 2506741 cttcaaattg tgtttgaaac cttttccgca ttcggaactg tcggccttac gatggggctt 2506801 actcctgaac tgacaacagc tggcaagtgt atcatcattg tcatcatgtt tatcggaaga 2506861 attggtcctt taacgttcgt gttttcattc gcaaaaacag agcaatcaaa tatccgttat 2506921 cctgatggcg aagtgtttac agggtgatat caaaaaaatc cggcgtgcag tcgccggatt 2506981 ttttatgatt cgatatgaga ttgattttgt cttttttcct gttccgcgat gatttcgtta 2507041 tcctccgcgt tatcacgggt cactttttgc gtaagaatcg caccaactgc tacaagtatc 2507101 ataacagcga tgtaataacc tttttcattg agttccagat tatcagcatt atagagtccg 2507161 atactaaaca aaaatactcc cgcaaaaaaa gtaaaataag ctagtactgt aaaggcaacc 2507221 gtgtttctgc gtctatattt ctgcaccttt gttccctccc gaaagcatag ttaaaaagtg 2507281 ataacttccg tggaatatta tacctcaaat tccccggaat ggaacaaaga attaaaaata 2507341 ccagtaaaaa gggcttaggt tgcctccttt atttcaacag ctgaatcatc aatccagccg 2507401 ataagtttat cattgatttg gaattggtac catacagact ggcctttctg ttttttagac 2507461 acaaccttta tgtctttgcc gacgtaagat tgggcagagg taagccttat ggaccgatca 2507521 tcagtagaag gcttggacca tacgtcttga acggcactgt ctttaataga ggcgtttaaa 2507581 tccacagatt tgagggatgg atttacctca tcgtactcat ctaaatcgta tttttccaca 2507641 atagcgctga ttttgtcagc gtagtcaggg tctgtagcat atcctgatgt ttgcagggcg 2507701 gttgccgctt ccttataatt ccctgcctca agcaccggtt tatacttctt tttattccac 2507761 gatgtgccac ggacgaacaa ttgggcgtga tcatccatag attcaaaaaa cgtgctgtat 2507821 tttcgaaact tcgcgcgaat ggtttttctt ttcccttttt caacttcgtc cgtttccatc 2507881 gtgacatgat ggcctttata attccctttt acgccaaaaa ggttgttggc cttagcagcc 2507941 agttcactgt tcccccagtc cgattcgaga atggcctgag caattgtgat gctggggaga 2508001 acatggtatt tttcatacaa aatttgggca tgtccggaca gactgtctat aaatacttgc 2508061 tgttcatcga tttcttcagt ttctttggat atttcaatcg gttttgataa agttgtcgct 2508121 aaaacaaaca gagctagcgg aatcgataca aggaaaaata gtgaaatcaa gagtttacgt 2508181 tttttaagtt ttttacgggc catgaaaacc ttccttcgaa ttaaaagatt acgaatgtaa 2508241 aagaatctac cttttagaat tttacttgca cttctaatat ttttcaattc tttagggata 2508301 aagttgggaa aagattgcaa aataaaaacc ttttcgctca atgaaaaggt ttttaccatg 2508361 tttctatttt tgtaaatttc tgagtgcatt ccgatattcc gtatcattta ttactttata 2508421 tgatttgaca gttgccttcg acaaaccttg tgctgagacg gccggttttt ccggagctgt 2508481 tttcgcttta tcatgtggtt tatgtgccag cttgtgcccc attccagtgg cattcataca 2508541 aaatgacagg cagacgagca gcacgctaag gataaaagaa atgaagaaga gatcatgata 2508601 agcagtcatc atagaatcct gtaccgaacc gctttgtctg gcagcatctt ttttcgtgaa 2508661 aaagccgatg agaatgggaa ctcccatata gacaaacaat cttaaaaact gaacagctgt 2508721 cattctcttg accaaatcag gcagcgggcc tcccatggca gctcccatca gccctgcggc 2508781 gactgtcagg cctgttcccg ctgcaagcat gataaacagt gccgcgaaca tataaagaga 2508841 tgatcgatcc tgtatatgca gccattgaaa attcacaaaa acgagaatga gtccgccgat 2508901 aataccgagc atccctggtc cgactttatc gtataacaga gcgctcaaaa tggccgcgat 2508961 cgccactccg attaaaagag tcaagcttaa aagaatgaga tgctcctgag aaatatcata 2509021 catttgacgg agcaagcctt gaaaagcaga aaggctgaca gctaccgtta tcgtccctgc 2509081 agctatgatc aataagccga gcaccggttt tggcagcagc atcagtttaa tagatatgaa 2509141 ggggtttttc actttatatt ccacaatcaa tagaccaatg agcaaacata acgtcacccc 2509201 gaaaccaatc catacataac ccgatgacag cccccatttt tgcagaaaaa tgaatgaaac 2509261 cgctgaggct gcggcaagga agacagataa aagaattccc gcacgatcaa gcggctgttc 2509321 ttgatccgcc gctccgtgat gctcatcatg aagaaagaaa tagctcaccg cgacaccgat 2509381 cagggacaag gtgccaaaga tgaaaaacag ccatctccaa tgcccgcagc ttgttgcaat 2509441 ggttcccagg attgtaccga tgataacaga accatagaat cccccgatca gcacaagcag 2509501 tgcatagttc ctgcgttcaa tcgggaatga cagtacaagc attggaatca taatcatcag 2509561 catgacgcct gttgccgccc cttgtaaaaa gcgccctgcc gccatcaatg caatatcgcc 2509621 tgaacatgcg atgagcagtg agcctagtat aaagacaggt aatgaagcca gatagacggg 2509681 acgagcaccg aattttttcc tcagcagcgg tcctgccgga actaacaagg caaaggccat 2509741 attgccgatc aatatcggat ttactgatgt aaagacactt gttccaaccg ttttctgaac 2509801 aaggccttga actgacgaca atgccgtgtt agacatcaat cccggcccga ccgctaagac 2509861 ggcgagcaaa gaaatcaccc aatagtgttt tgtcttcatg ttgtcatccc ttcctatatg 2509921 aatacatgcg aaacacatca ttttttgaaa acaaaagaag ctaatagatt ttgcatacca 2509981 ttagctttca ttctaatatt ctccctttca ggggaaatga tattatttta ttataattat 2510041 gtgaatgaat gagcatataa tcaaatatta tttcaaatcg attgtgtttt gtcaatggag 2510101 taaatttcaa gcacaacata gaaagcttga aagcttttcc ccgatattgt gtctagaact 2510161 gcacttatga atccctgctc gttccctcaa gcgaattaaa gcaggccgtt ttaatccttt 2510221 caatccacta ttccaactaa taaactcaaa taagttggtg ataagacaac attttacccc 2510281 cacatttttt tgtgttcact gggcgtttgc cgcctctaaa ttgtatatgg gtaaatacca 2510341 tgaattaacc tatgaaatac caatgtaagg gaggcaaaaa cgaatggaac tgtatgagtg 2510401 tatccaagac atttttggcg gcttgaaaaa tccatcggtt aaagatttag caacgtcttt 2510461 aaaacaaatt ccaaacgcag caaaattgag tcaaccgtat attaaggaac cagaccagta 2510521 cgcttacggc cgaaatgcca tctatcgaaa taatgaattg gaaattatcg tgattaacat 2510581 tccgccaaac aaggagacaa cagtacacga tcatggtcaa tccattggtt gtgcaatggt 2510641 gttagaagga aagcttctta attctattta tcgttcaacc ggcgaacacg cagaactctc 2510701 caattcatac tttgtccacg aaggagaatg ccttatttca accaaaggtt taattcacaa 2510761 aatgtccaat ccaacatctg aacgaatggt gtctcttcat gtctactccc ctcctttgga 2510821 agacatgacg gtctttgagg aacaaaagga ggtattggaa aattcatgat tgacagataa 2510881 actgctcact ttgacttcac tcaactggag gattcagaga atgaaacctt ttcctcaaaa 2510941 caaaaaaacc cttatcgaat aagggtttaa aggtatggag ccaagggggc tcgaacccct 2511001 gacctctacg ctgccagcgt agcgctctcc cagctgagct atggccccgt atgtaacgtc 2511061 atgtttatta tagatgattt tattttgaaa aacaagctgt ttcctcttga attgacagaa 2511121 aaaataaggc tcggaaaaga gccttatttt tcgacttaca tcatgatcaa aagtaaaatc 2511181 acaccgagaa taattcgata gattgcaaat gggacaagtt tgattttgtt aatcagcctt 2511241 aagaagaaac ggacgacaaa cagtgcgacc acaaaggcac agataaagcc gacgatgaaa 2511301 aacggcatca gatccgaact taagctgtcc caatgcttca cgaggcttag aaagctggct 2511361 cccatcatga tcggcatcgc cataataaac gtaaagtcgg ctgcagctcg gtggtttaat 2511421 ccgagaataa caccgccgga aatggttgaa cccgaacgcg agaaaccagg ccaaagggaa 2511481 agacattgga ataagccgac ggctatcgcc tgtttatagg aaatgcggtc gagtgtgtct 2511541 gtcgctgttt tccgtttatt gacccagtca gcaaaaagca tgaggattgc cccggcaatt 2511601 aaaccgatgg ccacagtttt aacggaaaat aaatattcat caatgtaatc ttcaaacaaa 2511661 aagccgagaa cagctgcagg cacgagtccg acggcaattt gggcaatgct taatttatgt 2511721 ccctgctcct ggtcgcttgt aatatttttt ttcaagccca gtaaatttaa aattcggtct 2511781 ttaaacacga tagctactgc taaaatggag cctagctgaa taaccacctt gaatgagtta 2511841 gcagcttctt ctgacatcag attacttgat tttagccaga tgtcgtctac tatgatcata 2511901 tgtcctgtcg aagaaaccgg cgcgtactct gttaatcctt ctacgattcc taaaatggcg 2511961 gctacaaaca attcccatag agtcatgatt ttgattctcc ccattagaca tttatttttt 2512021 tacataacgg gagcttccca taaatggaaa gcccgtctta tataactata aacgaaaatc 2512081 acactttatg ccccggcgta ttttcatttt tttcttcatc gtataaatgt gactgcattt 2512141 taaaccagtc aaataaatgt gtcgtaatga ctttggcaac cgcatagccg ggaatcgcaa 2512201 gaatgattcc aacaacgcca aacagcttgc cggctgttaa cagcagaaaa ataatcgtaa 2512261 tcggatggat gtgaaggttt tttcccataa tttgcggaga gatcagcttc ccttcaatca 2512321 gctgaacaat cgtccaaacg atcaccagct taagcagcat gagcggcgat gtcactatgg 2512381 caatgataat cgcaggcgta atggcaatcg ttggccctaa atatggaacg atgcttgtgc 2512441 aagccgcaat gactgcaagc aatgaagcat aatccagccc gataatcaaa taaccgataa 2512501 acagcaaaaa cccgatacag aagctgacaa tgatctggcc tctgatataa gagcttaacc 2512561 gatgattcat ttcgcttaag actgtatatg tctgttcttt caatcgagtc ggcacaaact 2512621 tcagtatgta gaccggtaat tttcttccgt cttttagcaa ataaaataga ataaacggaa 2512681 ccgtgacgat cgaaatgata atctcagtca gtgcgccgat aaaattccca acaccggtaa 2512741 aggtgctgtt cacgatcgtc gctgcctgat ccgaaacctt tgtagcaaga tcagatatat 2512801 taatgttcat cgtttgctgg gcctgattga cgaagttgct gccaatcagc tgtttcgtct 2512861 gattttctac gacgtccaca tatctcggga tattgtcaat caaactcata atttgttctt 2512921 ttaagaaggg aatgatcgac acgatcgtga tcgtgatcag cccgataacc aataggtata 2512981 gcagcaatat agaatagatt cttcttattc ttcttctctc cagaaaatcg acgactgggt 2513041 ttaacagata aaaaacaatg cctgtcaaaa taatcggaag tgatatcgtt ttgagcagaa 2513101 caataatcgg ggtgaaaata aatgatgttt ttgtaaatac tagaatattt aaaccaatca 2513161 gcagcagcac aagcaaaaat aaaacaaact tattatccaa gaagaatcgc ttgaatctgc 2513221 cgctccatgt ttgcaacgtc tccactatcg ttcctccgtc atacatagtt taattaaatt 2513281 gtacactatc gtccctataa tgaaaaataa aaaccgttaa ttgctggaaa agctttctcg 2513341 gttttaacat tctatttata tctatcatgt gattttgttc tttttaagct ataatttagc 2513401 tatatcatgc aaaaggagcg atacgagtga tacgttttgc aataatagga accaactgga 2513461 ttacagaccg ctttcttgag tcagcagcgg atatcgaaga ttttcagctg actgctgttt 2513521 attcaagatc ggctgaacgc gctggcgagt ttgctgctaa acacaacgct gcgcatgcct 2513581 tctcagacct tcaggaaatg gcggcgagcg attgctttga tgccgtatac atagcgagcc 2513641 cgaacgctct tcacaaggaa caagccgttc tctttatgaa ccatggcaag catgtgcttt 2513701 gtgagaagcc gtttgcttcg aatacaaaag aaacagaaga gatgatctca gcggctaagg 2513761 caaacggcgt tgttctcatg gaagcaatga agaccacttt cctgccgaat ttcaaagaac 2513821 tgaaaaaaca cctgcataaa atcggcactg tccgcagatt taccgcaagc tactgccagt 2513881 attcctcacg atatgacgcg ttcagaagcg gaactgtttt gaatgcgttt cagcctgagc 2513941 tttccaatgg gtcattaatg gatattggcg tctattgtat ttatccggct gttgtgttgt 2514001 ttggcgcgcc gaaggatgta aaagcaaacg gatatgcttt atcctccgga gtggacggag 2514061 aaggaactgt cattctgtct tacgacgggt tcgaagctgt tctgatgcat tccaaaatct 2514121 ctacttccta tgccccggct gaaatccagg gtgaagacgg gacgattgta atcgatacga 2514181 ttcaccggcc tgaacgtgtt gaaatccgct accgggacgg ccgccttgaa aacatcgcga 2514241 tccctgatcc taaaccggcg atgttctatg aagcagaaga atttgtcacg cttataaaag 2514301 agaataagct ggaatctgaa gaaaatacat ttgaacggtc tttgaccacc gcaaaaatta 2514361 tggaagaagc aagaaagcaa atggggattg tataccctgc tgatcaagcg aattcatgcc 2514421 agtcagcttt ctcacattaa tcttccagac gtttttcaag ctctgctttt ttctcttcaa 2514481 agccaggttt gccgagtaac gcaaacatat tgactttata cgcttctaca ccaggctggt 2514541 caaacggatt gacgccaagg aggtaaccgc tcatcgcgca ggctttttcg aagaaatata 2514601 caaggtatcc aaaagtatat gcattcagct caggaatgtt aacgattaag ttcggaacat 2514661 ttccgtctgt atgggcaagc attgtacctt ggaatgcttt tttgttaacg aaatcaacag 2514721 ttttaccggc taaatagttc aagccgtcaa gatcgttatc cgcttcctca attgtcagtt 2514781 catgtttagg cttctctacg ttcaggaccg tttcgaataa atctctgcgg ccttcttgta 2514841 catactggcc taaagaatga aggtctgttg aatagttcgc tgaagaagga taaatgccct 2514901 tctcatcttt cccttcgctt tctccgaaca gctgcttcca ccattccgca aagtattgaa 2514961 gcgccggttc gtagttgatg agcatttcaa ttgttttgcc cttattataa aggacattgc 2515021 gaacaaccgc atattggtat gctgggttat cttccagttc agatgttgca aaatctttgc 2515081 tcgcatccag ggcgcctttc atcatgtcgt caatgttgac gccgctgaca gcaatcggca 2515141 agagacctac agctgttaaa actgaataac ggccgccgac atcgtcagga attacgaatg 2515201 attcaaagcc ttcttcgtta gaaagcgttt ttaatgcgcc gcgctcttta tcagttgttg 2515261 cataaatccg cgctttcgct tcttctttac cgtatttctc ttcaagaagc ttgcggaaaa 2515321 tacggaaagc gattgcaggt tcagttgtcg tacctgattt agaaatcaca ttaatagaga 2515381 agtcaacatc ttcaagaaga tccatgacgt ctctcatata agatgaactg atgttgttcc 2515441 cgataaaaat gacttgcgga ttgccgcgtt ttgcttttgg caaagtgtta taaaacgcgt 2515501 gattcagcgc ttcaatcgct gcccgcgctc caagataaga accgccgatg ccgacaacaa 2515561 gcaagacatc agagtcagat ttgatttttt ccgcgctttt tttgatgcgc gcgaattctt 2515621 ctttatcata atgttcaggg aggtccaccc agcctagaaa atcgctgccc gcgcctgttt 2515681 tctcatggat attatggtgt gctgttttta caaagtcccg caggtatgta agttcatgtt 2515741 cgttgaagaa agtcaacgct tttgagtagt caaagcgtac atgcgtcatt gcttgtccct 2515801 ccataacggt ataatgtttt catctttcac tttatatgaa cttatctgtg aaatcaagtc 2515861 aagaagaaag ggcggaatga ctggattccg ccctttgggt ttatagagac gcgcgaagga 2515921 tggcaagcac gtcatctttg ttcagttttt ggaagttgcc gaagccgccg tgttccattt 2515981 ccttggctgc gatatcagca atcagctcaa gcttttcttc tccaatattg taatcagcaa 2516041 gacgagaagg tgcaccgagg cttgtccaga acgcagacag tttatcgatt ccttcaagcg 2516101 caatttcttt atctgttttg ccttcagtat caatgtcaaa catgttgagc ataaggtttt 2516161 taaaacggcc tacatttgta tcaagcgtgt atctcatcca atttgggaac agtattgcca 2516221 aaccgcccgc gtgcggaata tcatatacag ctgaaacagc gtgttccatt gtatgagaag 2516281 cccagtcacc gaagtatccc atttggagcg tgccgtttaa agcaatagta ccagcataca 2516341 aaatcgtttc acgaagttcg tagttttcca gatcttcaag aagcttagga gctgtttcga 2516401 tgaccgtctg caaaacagca aagcacattc tatcctgaag cggcgtgttt tcaacattat 2516461 ggaagtattg ttcgaatacg tggctcatca tgtcaaccat gccgtatact gtttgatttt 2516521 ctggaacggt gaacgtattt tcagggtcta aaatagagaa acgcggatga gtgacattgc 2516581 tgccccatac aaatttctcg tttgtttccc agtttgtaat cacggaatca gggttcattt 2516641 cagaccctgt tgcagcaaga gttaaaacag tgccaaacgg cagcgcatcc tccgctgtta 2516701 cttttttgct gaaaatatcc caagcgtcac cgtcatattt gacgccagct gcgattgcct 2516761 ttgtacagtc aatcacactg cctccgccga cagcaagcag aaaatcaatg tcatgctctc 2516821 tgcaaagtcc tatgcctttt tccactgtcg caagacgcgg gtttggctct acacctgaca 2516881 gctcatgaac aacagcgccc tcttctttta aaatgcctgt gacttgatca taaaggccgt 2516941 tgcgtttaat gctgccgccc ccgtaaacaa gcagtacatt cttgccgtat cgtttgaatt 2517001 cttttcttaa ttgttcaagc tgaccttttc caaaaatcag ctttgtcgga ttataataag 2517061 tgaaattttc catagtaaaa cctccaaatg atgctggtaa aaaacagatt ttccattgta 2517121 acataagttg acaaaaaaga aaaagggaag cagccaaacg gctatttccc ctttttttat 2517181 agtgatgctt tcaaaattga cagcacatct tctttgttga gtgatttaaa ttggccgaat 2517241 gtaccgttag ccattgcctt gtcagcgatt gtgtcaagct gctcatcatt aatatcataa 2517301 tcagcaagac ggttcggagc gccaagactt gtccagaatg cggacagctt atcgatacct 2517361 tcaagggcaa tttcttcatc cgttttacct gcttcttcaa catcaaacac gcgaactgca 2517421 agctgtttca tgcgggcagg gttttcagac aatgtgtgtc tcatccaatt cgggaacaga 2517481 atcgccagtc cgccggcatg cggaatatca taaacggctg atactgcatg ttcaatatta 2517541 tgagtagccc aatcccctct tgcccccata gaaagcatgc cgtttaatgc gattgttcct 2517601 gtgtacagga tcgtctcacg caattcgtaa ttttcgagat cattgatcag cttaggcgct 2517661 gtttcaatga ctgtacgcaa aagtgattca cacatgcggt cctgatacgg cgtgtttgat 2517721 acatgatgga agtattgttc gaatacgtgg ctcatcatgt caaccatccc gtagatcgtg 2517781 tggtttttag gtacggtgaa tgtattcacc ggatcaagaa tcgagaattt agggaatacg 2517841 agcgggctgc cccagccgta tttttctttt gtttcccagt ttgtaataac agatcctgag 2517901 ttcatttctg aaccagttgc agcgagagtc aataccgttc cgaatggcaa agcatctttt 2517961 ggctgatgct ttttcgtaac gatatcccac gcatcaccat catacttcgc tcctgcggca 2518021 atcgcttttg tacagtcgat tacgcttccg cctccgacag ccagcaagaa atcaatgttt 2518081 tgttctttac agatggcaac acctttatta acagtcgaca cacgaggatt cggttccaca 2518141 cctgctaatt catgcacggt cgctccggct ttattcagct gttcaatcac ttgatcatac 2518201 aggccgctgc gtttaatgct gccgcctccg tacacaagca atacgttttt tccgtaaggt 2518261 ttgagttcct ccggaagtct ttccacttcg ccgcgcccga aaattaattt ggtcggattc 2518321 cagtatgtaa agttttgcat gacatctcct ccttagattt tttattatgc agaatgtcct 2518381 caccacatgt aaagcaatca gctctcaccg atcagcatac cagatggttt tattttgcaa 2518441 ggtgctggga aagaagctga tataagcgag ggcaggccag cttccctcat atggagaatg 2518501 catgtataga ttctccaata tgtcacaatc tataactgtt ttaataattc atggaggagg 2518561 ttgcaaaaca tgagtaccat tcaaagaatt tgtcttgtat taaccatcat tggcgccatt 2518621 aactggggac tgatcggatt tttccaattt gacttagtag cggctatctt cggcggccaa 2518681 gggtcagctc tttcccgaat catttacgga cttgtcggaa tcgccggctt aatcaacctc 2518741 ggtctgctat ttaagccaaa cgaggaaaga tcacgtgaag aagcagcaaa tcctgaaatg 2518801 cgataggata tcaatcacgc tgaaatagga ttttgcatga aatcaaaagc accgaacatt 2518861 cctgtccggt gcttttttca tgcttatttt ttgataaggt ctttgcggtt ggacatttcg 2518921 atccactctt caagcttatc ttttaatgtg ttgaaacctt gtggtgtaga agcttcttcg 2518981 cttacttgag cagctttagg ttttcttggt ttgctttctt ttttctcagg cgcagcttgt 2519041 gtcgcacgaa ttgaaaggct gattttgcct ttttcttcat caacagcaag tacttttact 2519101 tgtacttcgt cgccaactga aaggtgctcg ttgatatctt ttacgaaacc gtgagtcact 2519161 tcagaaatgt gtactaaacc ttgagtttct tcatctaatg caacaaacgc accatacgct 2519221 tgtaatcctg taactttacc agtgtaaaca ctgcccactt caaattttgc tgccattcat 2519281 aacaactcct aagttaaatt aaatatctgt ttatacgcaa tttaaaatta tatcacacat 2519341 gtcttatttc cgcaaagaaa acttttttat aaaaaatcag gtttatgcac agcaaaaagg 2519401 gggtaaactg aaaataccaa aggctttcta gtattccccc cttttattgg atgcgaacaa 2519461 aaggttcgta tcttttttta tgttgttttg tgcaggaagc gtttcattct gactaacgct 2519521 tcttgaagct gttcaatcga ggttgcgtat gaacaacgga tatatccctc accgctcgga 2519581 ccaaacacac ttccaggaac aactgccact ttttcctgcg tcagtagctc ctcggcaaac 2519641 tgttctgaac tcattcccat gcttttgata gatggaaaag catagaaagc gccgcccgga 2519701 tgatgacagc tgagaccgat ttcattgagc gattctacaa acagattccg tcttcttcga 2519761 tagctttttt tcattttttc tacgtcttcc atgccgttct tcaggccttc aagggcggca 2519821 aactgcgcca ttgcgggcgc gcacatcatc gcatactgat gaattttaag catggcatcc 2519881 cgaagcaagg atggtgccgc ggcaaaaccg agcctccagc ccgtcattgc aaatgctttt 2519941 gaaaagcctg agatgactac cgtccgttcc ttcattcccg gtaatgccgc tatacttgta 2520001 aattcctcat catatgtcag ctccgcgtag atctcgtcgg ctaagacgat gacatcatgt 2520061 tttttggcaa actcagcaat ctcattcagc tcttccttcg aataaaccga acctgtcgga 2520121 ttcgatggtg agcagatgag aatggccttt gttttttcag tgactgccgc ttcaaaatca 2520181 gcagccgttg ctttaaatcc tttgtctgcc gttgtatgaa cgtgaaccgg gataccgcct 2520241 gccaaagaaa caagcgcatc gtacgcaaca aaacacggct caggaatgat gacttcctca 2520301 cctggattca caatggcgcg gatcgcaata tccaaagcct gacttgcccc cactgtcaca 2520361 atcagctcat tatctggcga gtagctaagg tcaaacctgt tgctcaaata acggctgatt 2520421 tcctcccgca atgagtataa acccgcattg gccgtgtatg acgtatatcc ttgttcaaga 2520481 gagagaatgc ttgcttcgcg gacattccat gcggtaacaa aatcaggctc gccgacgcct 2520541 aaagaaatga cgccttccat cgttgccgcc aaatcaaaga atttgcggat gccggatggt 2520601 tttatttgtt gtacatagtc tgataaatac gaagtcattt acggtgacac cacgattctt 2520661 ttgtcgtcgt ctcctgtttc aaacactttg ccgtcatgct tgtatttttt caggataaaa 2520721 tgggttgtcg tagatacaac tgaatcaagc gttgagagtt tatccgaaac aaaacgcgct 2520781 acgtcagaca tcgaattgcc gcgaatcacg acagacaaat cgtatacgcc tgacatcagg 2520841 taaactgatt caacctcttg gaatcggtaa atccgttccg ccacttcatc aaaaccgacg 2520901 ccccgcttcg gcgttacttt gacgtcaatc atggccgtaa cgccctcatg tccgtcgact 2520961 tttcgccagt caatcatagc ggaataatcg ataataacct tttctttctc cagtttgtca 2521021 ataattgttt tcacttcatt tacagggatg cccgccatct ttgcgattgt ttctaaatcg 2521081 gcgcggctgt tttcgtctaa aatttctaat atttctgttt ctttttctgt caatttcatt 2521141 tgattcacac ctttgcaatg tcaagaaatc tcatgacatt atatcacgtt ttttgacgaa 2521201 tgctaagaaa aaacgaggag aaacttccgc tagaattgac aatttcaggg cataatacaa 2521261 ccatcaaaaa aagggagtga cacagaatgg aggcggtttc accaataagg cggtttacgg 2521321 tcgatggagt caatgtatac tacgaacatt atcaaaatcc cggcaggcaa acgctggtct 2521381 gcgtacacgg ttttttatca tctgcattca gcttcagaaa agtaattcct ctccttcggg 2521441 acaagtacga catcatcgcg cttgatttgc ctcctttcgg ccaatctgaa aaatcaagaa 2521501 cgtttatcta tacctatcaa aaccttgcta agcttgtcat tgggattttg gagcacttgc 2521561 aagtgaaaca ggctgtgctt gtcgggcatt ctatgggcgg gcagatatcg ctgtctgctg 2521621 ctctccaaaa acctgagctt ttttcaaagg ttgtgctgct ttgcagttca gggtatttaa 2521681 aacgttcaca cccgacgatt attttcggga cccatatccc gtattttcat ctttacatca 2521741 aacgctggct ctcgaaagaa ggcgtgatga aaaatttatt aaatgtggtg catgacaaat 2521801 cgctgattga tgaggagatg attgacggct atggcagacc gtttcaggac gagcagattt 2521861 tcaaagccat gacaaggttt atccgccaca gagaaggaga tttagaaccc gagcaattga 2521921 agaaaatgaa caagcctgct ctattgattt ggggcgagga ggatcgaatt gtcccaatgg 2521981 agatcggtaa acggctgcac gcagatttgc ctaattccgt gctgtactca cttggccaga 2522041 ccggacatct ggtgcctgaa gaacggcctg aacttatttc tgaacacatt gctgatttta 2522101 tcaaataaca aaaaaaccgg tgctgaaccg gtttttttaa ggcgtgcagg agctgctgtt 2522161 tttaatgaat aaaagctggc cagccacttc ccggcagctg gcgatcggca gcgtttgttc 2522221 aaaagaagtt tcaaatattt gctgaatgct tttcgccagc aagtcgggat cgttttcatc 2522281 atagactgcc tgcacgacat caacagcctc cgtttcgtaa aactcttctc catatttaaa 2522341 cgggtcccat ttggcaatga tcttaatcat ttccctgacc gcatgacttt cttccatatt 2522401 catcaccgct tataataaaa tttgcagttc tatcttatca tagtgaagct tagaagaata 2522461 aacatacatg agggggtaac agaatgaact ttgataaacg agaagaacgc cttggcaccc 2522521 aatcggtcaa atgggataaa acaggcgaat tatttggcgt gacagacgcc ctcccgatgt 2522581 gggtggcaga tatggatttt cgcgccccgg aagcgataac tgaagcgtta aaagagcgtc 2522641 ttgaccacgg tatttttggt tatacaactc cagatcaaaa aacgaaggat gctgtgtgcg 2522701 gatggatgca aaacaggcac ggctggaagg taaatccgga aagcatcaca ttcagccccg 2522761 gcgttgtaac agctttgagc atggcggtac aagcttttac ggagccgggc gatcaagtag 2522821 ttgttcagcc tccagtttat acgccttttt accatatggt ggagaaaaac ggccggcaca 2522881 ttttacataa tccgctgcta gaaaaagacg gcgcatatgc aatcgatttt gaagatttgg 2522941 agacaaagct tagtgaccca agcgttacat tgtttatttt atgcaatcct cataaccctt 2523001 ctgggcgttc atggagccgg gaagatttac tgaagctagg cgaattgtgc cttgagcatg 2523061 gcgtcacagt tgtatcggat gaaatccatt ccgatttaat gctgtacgga cataaacaca 2523121 cgccgttcgc ttcgctctct gacgatttcg ctgatatttc cgtgacatgt gctgctccaa 2523181 gcaaaacatt taatatcgcc ggattgcagg cttcagcgat cattattccg gatcgcctga 2523241 agcgcgccaa gttttccgca agccttcagc gaaatggttt aggcggactg aacgcgtttg 2523301 ccgtcactgc aatcgaagcc gcgtattcaa aaggcggacc gtggcttgat gaattgatca 2523361 cttacattga gaaaaacatg aacgaagcgg aagccttttt gagcaccgag ctgccaaagg 2523421 tcaaaatgat gaagccggat gcatcatact tgatttggct cgacttcagc gcttacggct 2523481 tgtccgatgc agagcttcag caaagaatgc taaaaaaagg aaaagttatt ttagagcccg 2523541 ggacgaaata cgggcctggc ggagaaggat ttatgcgcct gaacgccgga tgctctcttg 2523601 caaccctgca ggacggcctg cgccgcatca aagccgcatt atcgtaaata tagctgtaaa 2523661 cgcctttacg tcttcatttg taaaggcgtt cttaataaag gaattttata ttttacttct 2523721 aatatttagt gttataatag attcatattt tatacgaaag gatttcacac gaatggaaat 2523781 tctaaaagac tatcttctgc acatctgctt tattttgttt cctattcttc tttaccaagt 2523841 gttttggctt ggaaaacctg cgattcttgt gccaaaaata aacagcggtt tggtcacgct 2523901 cttcgcctgc ggcgcctccg ttttatgcat tattttcccg attcatgaaa tggactacat 2523961 acaatacggc cttcagatga ttcccgttat catttgttta ttttacatta gtaccgcttc 2524021 cggacttaca gtcgccgcat ctgtcctatg ttttgaactg cttttttacg aaccttccgc 2524081 aatgtttgtt ttcactttgc tgccttttct tatcattatc ccaatcttat ttcagaaaaa 2524141 atggccattc atgtccaaag cgaaaaaact gctgctgtct ttattgatca gctgcgtgga 2524201 gattttccta tttttcgcct caagctggat tctttccgcc ttgaatattt taaattttca 2524261 aaaatcagga attttcgttt acgaggcggc agtctcaggg cttttccgct ccagtgttct 2524321 tctattaagc atctatatta tcgaaagcat cgccgaaaat atcgccctgc gttcacagct 2524381 tatccattct gaaaaaatga cgattgtgag tgaactggca gcgagcgtcg cccatgaggt 2524441 caggaatccg ctgacagttg tccgcgggtt tgtccagctg ctttttaatg acgaaaccct 2524501 acaaaacaag tcgagtgcgg attacaaaaa gcttgtactg tcagagcttg accgggcgca 2524561 aggcattatc acaaactatc tcgatatggc caaacagcaa ttatacgaaa aagaggtttt 2524621 tgacctatct gcccttatca aagagacaag ctcccttatg gtgtcgtacg ccaattacaa 2524681 gtcagtaacc gtcgaggctg aaacagaacc ggaccttttg atatacggag acgcaacaaa 2524741 gctgaagcag gctgtcatca acctgatgaa aaacagtatt gaagcggttc ctcacgggaa 2524801 ggggatgatc cacatatcag ccaaaagaaa cggccatacg atcatgatta acatcacaga 2524861 caatggggtc gggatgacag accatcaaat gcaaaaactc ggcgaacctt attattcctt 2524921 aaaaacgaac ggaacgggac tcggcctcac cgtaaccttt tccattattg aacatcatca 2524981 cgggaccatt tcatttaaca gcagcttcca aaaaggcact acggtgacca ttaagcttcc 2525041 cgctgatctt cctcactagc aaatcgattg gaactttaat agaataaatg cgaggtgatg 2525101 acagatgagc acgtttgaga caggctctat cgttaaagga ttttacaaaa caggtgtata 2525161 cataggagaa atcacggctt gcaggccgca gcattattta gtgaaagtga aagcggttct 2525221 tacccatccc gctcagggag accttcatca tccaaaacag gcggatgtgc cattttttca 2525281 tgagagaaaa gcgctcgcat atggtgaaca gaccaatatc ccccaccata tggtgaagcc 2525341 ttatgacggt gaagtgccgg attataccga atctctgcgg gaggcgacag cacagatgag 2525401 agccaaattg aatgaggatg gttcggagtg ggcaaagcgc tcccttcata atctggacat 2525461 tttagaaaaa gaatatttta accggccata acccagtctg acaaaagatt gggtttttta 2525521 cgtcgcgcgc ttcaacagtt cggttaaatc gattctctcg ccgattgtgg gcggttttgg 2525581 cttttcgaga tactgcttat cctgctcaac aagcttaaaa agtttatatg ctgtgagagc 2525641 atcatcaagc gctttatgat gggtgccggt tccggaatct ccatactctt cggcagcttt 2525701 ccataaaccc gtcaatgtcc ggtctccaaa aaagtttttg tattcaagcg ataaatctct 2525761 catttctccc ttaaacggga aagggatatg gttaaacata cagttttgct tcagcacttt 2525821 catatccatg tttccccacg taataattgt gctgtttttc tcaggatcca gctcgtttag 2525881 tttacggatg aaatcctcga atctcattcc ttcgtctacc tgtttttggg ttatttttaa 2525941 aaatgatttg cagcgtttcg taagcttcgg gaactttttc ggtctaacat agctagaaaa 2526001 cgtctcaacc acttcatcat caatcgactt tacaattccg gcttcaatga tttccgggaa 2526061 gaagttttga ggactgtact ttccatcagg cattgtaaat tcgaaatcaa taatgagtaa 2526121 gctgtttgtc gtcacctttt acacctgcct ttcctccgat cagaaaatgc tatctttata 2526181 gtatatcaat tccccttctc gacatttctt cattttctaa aaataatgaa ttttcccagc 2526241 cgcttcgttt cttttaaatt gtgaatcgtt tctttataat tagtaaggaa cccgaaataa 2526301 taagaaggtg atgttatttc tatccgtaag aaaaactttg tcattgtgtg gctggcgaac 2526361 ttttttgtct ccgctagcac aacgatgatc gttccttttc tctccttata cattgagacg 2526421 ctcagctctt tttcaaacgg ctttgtgcaa aggtggagcg gctatgtgtt cggcattaca 2526481 tttctcatgg cgtttttggt atccccgttt tggggacggt tcggagacaa acgcggatac 2526541 aagaaaatcc ttatggcaac cggaacaggc attgccctca gcattttctt catgggcttt 2526601 gttacatcgg tgtaccaatt gttttttctg cgtatggcaa tgggtcttgt aaccggattc 2526661 atcccgacat ctcttgcgat gatttcggca cagactccga agagctcagc tggcaaaaca 2526721 ctcggcacgc tgcaaatggg gcaagtgtcc ggaagcttgt tcggcccgct tttgggaggc 2526781 atgcttgctg atcgtttcgg ctttacgtat acctttttta tcacatcctt tgtgattttc 2526841 tcgtctgttc ttctcgtgtt atttggtgtc aaagaaaagc atcttgcaga gaaaacagcc 2526901 aaacgtacgt cttactcgag aaaagaagtg ctctcctata tttttcacca tccggcgctg 2526961 tgggtcatga tgctgttaac catgctgatt caaacaggca atttcagtat ccagcccctg 2527021 ctcgctttat atgtaaatga gctgcacgga cctgtcaatc ttgccttttt ctccggcatg 2527081 gcattttcag caacggggct cggaagtttg ctgctggcta gaaaatgggg tgatctgggc 2527141 gaccgctacg gccaccgccg cattttaatc ggacttttgc tcgccgcctc tttctttttt 2527201 attccgcagg cgctcgcgtc ctcactcagc gtgctccttg ttttcagatt tttattcgga 2527261 atggcgatgg gcggtttgct gccatgcatt acggcagcga tccgcgttca ggctcccggc 2527321 agcattcaag gtgaagttct cggctacaat gtcagctttc gctttttagg aaacgtgctc 2527381 gggcctctgc tcggcggaat catatcgagc cattttacca tttcggccac cttttacgtc 2527441 acggcgtttc tctttttcgc cggcgcctgc atgctttgga tcatgcagaa acttcggaaa 2527501 gattcttatg ccaaagcaag ctgattccga gaaaaaacta aggaatcttc taaatttaac 2527561 cttctcgtaa tctcaaaaga atggtacgat atggctagaa tttaggagaa aagagagtga 2527621 ccatgttacg aaaaataatc ggatggattt tgctcctttg cataatccca ttgtttgcat 2527681 ttacagttat cgcttccgga aaagaagtaa aacaaatgaa gtccctggat caggtgcttg 2527741 ataaaaatat tgatctgaaa gatatcagcc ttgttcagaa cagctacatg tatgacaggg 2527801 acggctccct tgtctcggaa atcgtcagcg accacgaaaa ccgtgtgctc gttccattta 2527861 acaagattcc cgaggaagtc aaacagattt tcttaacatc tgaggaccgc catttttacg 2527921 agcataaagg ctttgacttt atgggaatgg tgcgggctac tgcttctaac gtaaaagaca 2527981 agaaaattga ccagggtgcc agcaccatca cacagcagct ttcaagaaac ttgtatttga 2528041 gccacgaacg ctccttcagc cgcaagctga cagagctcgc gtattcctat cagctggaga 2528101 aaaaatatac gaaaaatgaa attcttgaag cttacttaaa taccatttat ttcaacaacg 2528161 gtgtttacgg cgtcggttca gcagctcaat tctatttcag caaaccgctg aaatctctca 2528221 cagtgggaga aatggctttt atctgtgcta tacctaataa ccctacatta tatgatcctc 2528281 tcaagcattt tgactacacg aaaagccgtc aagaacgttt acttaaaggg ctaaaagatg 2528341 ccggggtcat tacggacaaa gagctgaaaa aagccgtaaa acaaaaaatc aaactggatg 2528401 ttgaaaaaag agaagacaaa tatcctgact acgtttccta cgtcaatgat gaattcactc 2528461 agctggtgtc tgaatcagaa ggctttgata aacgccttca aaaagcatca ggaaaacaaa 2528521 aagaaaagat cgagaacgag ctgtccgcaa gagtcagcac gctgatgaaa gacggagtga 2528581 aaatttatac tgcacttgat ccgtacatgc aaaatcaagt tgtggcacaa atgaattcca 2528641 agctcccgta tgcggacgta cagggcggag cggctgtgat taatcaccag acgcatcaaa 2528701 tcattgctct atccggcggg aaaaactatc aaaaatatga ctttaaccgc gcctaccagg 2528761 cgtacaggca gccgggttca tccattaagc cgcttcttga ttacggccct tatattgaac 2528821 agaccggcgc gacaacaagc agcaccattg atgccagcaa gttttgcagc aaagactact 2528881 gtccgcaaaa ctacaataac cgcacttacg gcacagtgac gcttgatacg gcgtttaaaa 2528941 attcatataa taccccggct attagaatgc tcgaccgcgt cggcatccaa aaggcattca 2529001 gttatattga gccgtatcat tttgccaaac ttgtcgacag tgactatctt cttccggcgg 2529061 cgcttggcgg atttacaaac ggcatgacgc ctcttgagat gacaaaggct tatacgacat 2529121 tcggaaacag cggaagctat acgccgagcc atgcgattac aaaggtgaca gaccttaaag 2529181 gaaaaacact ttataaatgg aatgataaag cgactcaaat attcagcgtc cgcacgaaca 2529241 tgcagctgaa aaaactgatg tcttccgttg tgaaaagcgg aacagggaaa aaagcatatt 2529301 tcaatgcgcc ttacatcggc ggtaaaaccg gaacatcaaa tgattatcac gatatgtggt 2529361 ttgtcggcct gactgatacg tatacaatgg gtgtctgggt cggaaaggat acaccgacca 2529421 gcgttgaata tcttcacagc atcagccctc agctttccat ctggaaagga acgctgcaag 2529481 cggcttatta aaggatcgga ggggatatgg agtgacttca gaacaaattc caaatcgcgt 2529541 tttgctgttt gacggtgtct gcaatttatg caatggcgcc gtgcagttta tcattaaacg 2529601 tgatccggac ggattgattt ctttcacatc gctgcagtcg gaaacaggac agagcctgct 2529661 gaaaaaaagc gggcttccga ctgatcggtt tgacagcttt gtctttattg aagacggcca 2529721 agtgtacaca aagtcaactg cagccattaa ggttttcagg catctgcgag gcccatggcg 2529781 gctcttcgtc ctttttttcg cagtgccgaa gcctgtcaga gatatggtct attctttcat 2529841 tgccaaaaac cgctataagt ggtttggcaa aaaaaatgaa tgtatgctcc cctccccttc 2529901 cattaaaaaa agatttttac cgtaaataaa aaatggctag gaagctagcc atcacagatt 2529961 gttgacaaaa tcctaaaacg gcttcgtttt aggattttgt catctattca gcgtgattga 2530021 aaacttttga agttgtgaaa cggcggaaac ctgagaatct agccgccgtt tcattgcgta 2530081 cagagcacga agcgcaaatc tgaccaccaa acgctgaaat ggctagctta cacaggtaag 2530141 ctagccatta tgctattata aagcttgata aatatgaaca gaataccgat aacaaaggta 2530201 aaccaaaaca gcagttccaa tagaatgaat ccaactaatg acatgagaga aagcgtcgaa 2530261 taaatccggt atacggtaaa cacaaagtaa gcgagcgtga cgaccgcaaa ccagatcaca 2530321 atccaaatga cattttgcaa gagcacaaag gataaaatcc cgccgcccaa ataaatcatg 2530381 gaacccattc tgagtttttt caggttgttc ccttccggat cattagcaaa aaacagcaat 2530441 gacagctcgg tcacggtatt tgcaattaat ttcagagcgg acagaaccat aaaatataaa 2530501 agtgcaaagg cagcaaataa cgcaagcctg attcctttct ctgaaaaata atcgagcatt 2530561 ccatcataca ttccaaatga agacagcatc ttcaacgcat aaagtgaagt tgagatggat 2530621 aaggacgaac taaaaagcag gatcgcaatc agcggaaaat atcctgtcaa ataagtattt 2530681 ttcatataaa aaagtccctt tctataatct acctcattta ttatggagga cttaaaacac 2530741 attgacaaga taaattattc cattttttct cctttttacg aattacgggc ccaaatcttc 2530801 acaaagcagc attttgagag taaagtagta cgcaggaatc ataaaacgta aggaagtttt 2530861 atatgaaaaa aacattaaaa ctgcaaacca gactcaccat atttgtttgt atcgttgtat 2530921 taatcgcatt gctcattacg ttttttacag tcggtgccca aaccaccaaa cgaattagag 2530981 atcaggaaaa ggccactgcg ctgcagactg ctgaaatggt agctgaagcg ccgatgacag 2531041 ccgctgcttt agaaagcgga aaaaaacaaa aggaactgca gagctacaca aagcgggttc 2531101 agaaaattac cggcacggaa tttgttgtcg tcatggatat gaacggtatc cgcaaaactc 2531161 atcctgaccc gagcaaaatc ggaaaaaaat tcagaggcgg tgatgagtcc gaggtattaa 2531221 aagggcatgt ccatatcagc acagcctctg gcacgctcgg gaaatcgcag agagcgttcg 2531281 tccctgtcta cgcggagaat ggaaaacagg tcggtgcagt cgcggtcggc atcaccgtaa 2531341 atgaaattga tgaagtgatc agccatagct tacggccgct ttactttatt atttgcgtca 2531401 gcatcttcgt cggtgtgatc ggagccgtta tcgtcgcccg tacagtgaaa aatatcatgt 2531461 acggacttga accttatgaa attgcgactc tgcttgaaga acggagcgcg atgctggaat 2531521 cgacgaagga aggaatactc gctgtcgatg aacatggcaa aattaaactt gccaacgcgg 2531581 aagcaaaacg cctattcgtc aaaatgggca tcaacacaaa tcccattgat caggatgtag 2531641 atgacatctt gccgaaaagc cgcttgaaaa aggtcattga gacaaaaaaa cctcttcaag 2531701 acagagacgt ccgcattaac gggctggagc ttgtgtttaa tgaagttcct atccagctga 2531761 aaggacaaac tgtcggagcg attgcaacat tccgcgacaa gaccgaggta aaacatttag 2531821 ctgaacagct ttccggtgtt aaaatgtatg caaacgcact gagagcgcag tctcatgaat 2531881 ttatgaacaa actgcatgtg atattaggtc tcgtccagct gaaagagtat gatgatcttg 2531941 gagattatat taaagatata gccatacagc aaaaatcaga aacaagtgaa attataaatg 2532001 atgtcaaaag ctccgtactg gccggttttc tgcttggaaa gcaaagcttt atacgtgagc 2532061 agggcgcaaa tcttgatatt gaatgcaacg gtgtcatccc gaacgcggca gacccttctg 2532121 tcatccatga acttattaca atcatcggaa atctcatcaa caatggctta gatgccgttg 2532181 ccgatatgcc gaaaaaacaa atcaccatgt ccatgcgctt ccataacagc atacttgata 2532241 ttgaaattac cgatactgga gcaggcatgt ctgaagaaga ccaagccaaa gtatttgaac 2532301 aaggctattc aacaaagggc aaaaaccggg gattcggcct ttatttcaca cagcaaagca 2532361 tcgaaaattt aaaaggccaa atgatcctca caagcgaaaa gaatgaagga acgacattca 2532421 gtattcgcat cccgtacgaa ccgaaggagg aaaatcatga ttaatgtact aatagttgaa 2532481 gatgacccca tggtgggtga attaaataaa cgatacttaa gccaaataga tggctttcag 2532541 ctgaaaggca tcgcttcttc ctttcaaagc gctctgcata ttttagggga gcaccatatt 2532601 gacctcattt tgcttgatat ttatatgccg ggaaaaaacg ggctggaact gctgacggaa 2532661 ttgagagccc aaaatgaagc ggttgacgtg attgtcatct cagcggccag cgagcttgac 2532721 gtgatcaaga aaacacttcg gtacggagct gttgattatt taatcaaacc gtttgaattt 2532781 gaacgattcc aaacggctct gtctgattac agacgaaaac aaaaggtgta ttcaacccat 2532841 cgcaacatga gccaaaaaga actggacgcc gagctttttc aaaagaaaga agcaacagaa 2532901 aaagtgcagc ttcctaaagg cctgacaaaa agcacgctga agctgatctg gtccagtatc 2532961 cagtcatttg aaaatgaatc ttttacgaca gaagacttgg caaagcacac agaaatctct 2533021 caagtatcca tacgaaaata cttaaagttt cttgaagata tacaggttct gaatgtagaa 2533081 atggcgtacg gaacgatcgg aagacctgtg tttcagtaca acgtcaacaa cagtaacatt 2533141 aacggaataa agcaatatct ataagaaaac gcactgcttg ctttgagcag tgcgtttttc 2533201 tgtcatatct cttgccaaga tgcttgattc tattgttgat aagttataca agaataacaa 2533261 agggctttca catttttaag caaataattc taaaaataga taatttttaa aaaattatgc 2533321 gaaattctat ttatttctta ttagttaaat gataaattat gattggttag ttgatcccga 2533381 aaaactaagt cataagtctt acttcagaaa acgatgtcac ggttttccgc ccggaacgcc 2533441 ttccgcatcc ttctcttccc cgcctttcga aggaaatact cacaccacgc ttattcaggg 2533501 aagaatagaa ctgtctcagc gcattccatt tgttattatc agaaaatttt atcgattcta 2533561 agaaattgtt caggacagcc catcacatga ctggccggat cagctttgaa ccaaattttt 2533621 ctggggggtt atatcttgaa taaacgaaaa atcggattgg cgatgtcact tgtgatcgca 2533681 gcaggcacca tattaggagc atgcggaaac agcgaaaaaa gcagcggctc aggcgaaggc 2533741 aaaaacaaat tcagtgtggc gatggttact gacgtaggcg gagtggatga caaatccttc 2533801 aaccaatcag cctgggaagg catccaagcc tttgggaaag agaatgggct gaaaaaaggc 2533861 aaaaacggtt acgactatct tcaatccaaa tctgatgcag actatacaac gaacttaaat 2533921 aaattggcgc gtgagaattt tgacttaatt tacggcgtcg gctacttaat ggaggattca 2533981 atcagcgaaa ttgctgacca gcgtaaaaat acaaactttg cgattataga tgctgttgtc 2534041 gataaagaca acgtcgcaag tattacgttt aaagagcagg aaggctcatt tctcgtcgga 2534101 gtggccgcag ccctatcaag caaatcagga aaaatcggct ttgtaggcgg catggaatca 2534161 gagttgatca aaaaattcga ggtcggcttc cgtgccggcg tgcaagcagt taaccctaaa 2534221 gccgttgtag aagtgaaata cgcagggggt ttcgataaag ccgatgtcgg taaagcaacc 2534281 gccgaaagca tgtataaatc aggcgtagat gttatttatc actctgcggg cgccactggc 2534341 acaggcgtct ttactgaagc gaaaaacctg aaaaaagaag atccaaaacg cgatgtctgg 2534401 gtcatcggtg tcgataaaga ccaatacgca gaaggccagg tagaaggaac agatgataac 2534461 gtcaccctca cttccatggt gaaaaaagta gatacagtcg ttgaagatgt aacgaaaaaa 2534521 gcgagtgacg gaaagttccc gggcggcgaa acacttacct acgggcttga tcaagacgga 2534581 gtcggcattt ctccatctaa acaaaatcta tcggatgatg tgatcaaagc ggtcgataaa 2534641 tggaagaaaa aaatcatcga cggattggaa atcccggcaa ctgagaaaga gctgaaaacc 2534701 ttcaaagctg aataagaatc gcagggataa ggaggtcgag cccttatccc ttgtttttct 2534761 tttattttga aataaaggag cggtcaatca atggaatatg tcattgaaat gctcaatatc 2534821 cgcaaggcgt ttccaggtat cgtcgccaat gacaatatca atcttcaagt caaaaaaggc 2534881 gaaatacacg cgttgctcgg tgaaaacgga gcggggaaat caacattgat gaatgtcctt 2534941 ttcgggctgt atcagccgga gcggggtgaa attcgggtgc gcggcgagaa ggtgcacatc 2535001 aacagcccga acaaagcgaa tgaccttgga attggaatgg tgcaccagca ctttatgctt 2535061 gttgacacct ttacagttgc tgaaaatatt attctcggga aggagccaaa gaagtttggc 2535121 agaattgacc ggaagcgtgc tggccaagag gtgcaggaca tttccgatcg atacggcctg 2535181 cagatccatc ctgaagcaaa agcagctgac atatcagtcg gtatgcagca gcgcgcagaa 2535241 atattaaaaa ccctctaccg cggtgccgac attctgattt ttgatgaacc gacggctgtt 2535301 ttgacgcctc atgaaattaa ggaactgatg caaattatga agaacctggt caaagaaggg 2535361 aagtccatca tcttaatcac ccataagctg aaagagatta tggagatttg tgaccgcgtt 2535421 acggttatcc gtaaaggaaa aggcatcaaa acccttgatg tccgtgatac aaaccaagac 2535481 gaactcgcca gtctaatggt cggccgtgag gtatcgttca aaactgaaaa gagagctgct 2535541 cagccgggag cggaagtgct tgcgattgac ggcataactg taaaggatac ccgcggaata 2535601 gagacagtca gagatttgtc tctttctgtc aaagcgggag aaatagtcgg catagcaggc 2535661 gtcgacggaa acgggcaatc tgagctgatc gaagcggtga caggactccg caaaacagat 2535721 tcaggaacaa tcaccttaaa cggaaaacag atccaaaacc tgacgccaag aaaaatcact 2535781 gaatccggga tcgggcatat tcctcaggat cgccataaac acggtctcgt ccttgatttt 2535841 ccaatcggag agaatatcct gctgcaaagc tattacaaaa agccgtattc agcattgggc 2535901 gttttacata aaggcgaaat gtacaaaaaa gcacgcagcc tgatcactga gtacgatgtc 2535961 agaacgccgg atgaatatac acacgctcgg gcattgtcag gcggaaacca gcaaaaagcg 2536021 attatcgggc gggaaataga ccgaaatcct gatttattaa ttgccgccca gccgactcgc 2536081 ggccttgatg tcggagcgat tgaatttgtc cataaaaagc tcattgagca gcgtgatgcc 2536141 gggaaagccg ttcttctcct ctcgtttgag cttgaagaaa ttatgaatct cagtgacaga 2536201 atcgccgtta tttttgaagg acgcattatc gccagcgtta atccgcagga aaccactgaa 2536261 caggagcttg gtctcttgat ggcaggaagc acgcaaaagg aagcggggaa agcaaatggt 2536321 taaacgactc tctcatttac tcgtgccgct catcgcaatc atacttggtc ttgcggccgg 2536381 cgcgttgatt atgcttgtga gcggctacag tgtggctagc ggatattcgg ctttgtggaa 2536441 tgggatattc ggagaaatct attatgtcgg agaaacaatc cggcaaatta cgccttatat 2536501 tttatccgga ttggctgtcg cctttgcatt ccgaaccgga ctctttaata tcggcgtcga 2536561 gggacagctg ctcgtcggct ggacagcagc ggtttgggtc ggtacggcgt ttgacggacc 2536621 ggcatatatt cacttgccgc tcgcattgat tacagcggca gctgcaggag gattatgggg 2536681 gtttattccc ggcattttga aagcgcgatt ttacgttcat gaagtcattg tcaccattat 2536741 gatgaattat atcgcgctgc acatgaccaa ttacatcatt tcaaacgtct tgacagatca 2536801 tcaggacaag acggggaaaa ttcacgaatc cgcctccctc cgctctcctt ttcttgaaca 2536861 gatcaccgat tactcacggc tgcatttggg aatcatcgtt gcccttctcg cagcagttat 2536921 catgtggttt atcatcaaca aatctacaaa aggatttgag ctccgggcgg tcgggtttaa 2536981 ccagcacgct tcccagtatg ccggcatgag cgtgcggaag aatatcatga cctccatgct 2537041 tatctccggc gcttttgcag gtcttgccgg agccatggag ggcctaggga cattcgaata 2537101 cgcagcagtg aaaggcgcat ttaccggcgt aggctttgac ggtatcgctg tcgctcttct 2537161 cgggggaaac acagccgtag gcgttgtact ggcagcatgc ctgcttggcg ggctgaaaat 2537221 cggcgcatta aatatgccga ttgaatcagg cgttccatca gaggtcgttg atattgtgat 2537281 tgccattatt attctatttg tggcttcaag ctatgcgatt cgtttcgtca tgggcaaatt 2537341 gaagaaaaag ggggcgaact aagtggacat tgtgcagatt ttatctatca ttgtccctgc 2537401 cacactcgtc tatgcggccc cgcttatttt aactgctctc ggcggcgtgt tttccgagag 2537461 atcaggtgtg gtgaatatcg gcctagaagg cctcatgatt atcggggcgt tcaccagcgt 2537521 gttatttaat ttattttttg gtcaggaatt aggtgccgcc gcaccttggc tttcgctcct 2537581 tgccgccatg gcagcaggcg ccctgttttc actgattcac gcggcagcgg cgatttcgtt 2537641 tcgcgccgac cagacagtca gcggtgtcgc cattaacatg ctggcgcttg gggcaacttt 2537701 atttatcgtc aaactgatct acggcaaagc gcagacagac aaaattccag agccttttta 2537761 taagacgaaa atccccggtt tgggcgatat tcccgtcttg ggaaagatct tcttttcgga 2537821 tgtctattat acgtctattc ttgcaatagc acttgccttt atttcctggt ttatcttgtt 2537881 caaaacgccg ttcggccttc gtatccgttc tgtcggcgag catccgatgg cggccgatac 2537941 gatgggaatc aacgtatata aaatgcgcta catcggcgtg atgatcagcg gattgttcgg 2538001 cggtctcggc ggcggcgtat atgcctccac aattgcgctt gatttcacgc actctaccat 2538061 ctccgggcaa ggttttatcg ccctggcagc gcttgtattc ggaaaatggc atccgatcgg 2538121 agcactgggg gccgccctgt ttttcggatt cgcccaaagc ttaagcatca ttggatcgct 2538181 gctccctctt tttaaagaca taccaaatgt gtatatgctg atggctcctt atatcttaac 2538241 gattctcgct ttaaccggct ttatcgggcg ggcagatgcg ccaaaagcca atggcgtgcc 2538301 ttatattaaa ggaaaaagat aaacattctc ccctgggaag acgattctca gggatttttt 2538361 tctaatccaa aagaccccct taatttaatt gtttattagt tttttaactt aaaaaaatat 2538421 gaagtgttaa cgctttcttg tagactgtaa caaacaatac atgggggtgt atgacatggg 2538481 agcaattcca aaaacgggga caatttcacc tgagcaaaaa gactcacagg agaaaaacct 2538541 gtttcaaaaa atttggtctt gggaaatcgg tgtgattcct ttgccattat acacagtatt 2538601 agctgttatt attattcttg cagcatatta caatgagctg ccggcaaata tgcttggcgg 2538661 gtttgccatc attatgattc ttggtgtgtt tctcggagac ataggccaac gcataccgat 2538721 attgaaggat attggcggcc ctgctatttt atctttgttt gttccttcat ttttagtctt 2538781 ttacaatgta ctgaattcaa catctttaga cgctgtaacc aacttgatga aaacgtctaa 2538841 cttcctttat ttctatatcg cttgccttgt tgtgggaagt atcctcggta tgaacagaat 2538901 tgttttaata caggggttta tcagaatgtt cgttccactg gttgcaggaa cgatcgcggc 2538961 cgttgcagcc ggcatccttg tcggatttat ttttggctat agtgcctatg attccttttt 2539021 ctttgttgtt gtcccgatta ttgccggggg aataggtgaa gggattttgc cgctttcaat 2539081 cgcctattca caaatactgg gctcatccgc cgatgtattt gtgtctcagc tggtgccagc 2539141 cgcaattata ggaaacgttt ttgctatcat atgtgcagcc ttaatgaaaa agcttggcga 2539201 caagcgtcca gatctaaatg ggaacggacg tctcgtaaaa tctaaaaaag caaatgagat 2539261 tttcaatcaa aaagaagccg aagcaaaaat tgattttaaa ctaatgggag caggagttct 2539321 gctcgcgtgt acattcttta tttttggcgg gttattggag aaattcatct tcatcccggg 2539381 cgcgatctta atgattattt cagctgcggc tgtcaagtat gcaaatattc ttccgaaaaa 2539441 aatggaagaa ggcgcttacc agctttataa gtttatttct tcaagcttta catggccgct 2539501 gatggtcggt ctcggcatcc tctttattcc gttggatgac gtagcgtctg tgatttctat 2539561 accgtttgtc atcatctgta tttcagttgt tatcgcgatg attggttctg gatatttcgt 2539621 aggcaagctg atgaacatgt atccggttga atccgcaatc gttacctgct gccacagcgg 2539681 tctcggcgga acgggtgatg ttgccatttt atcggcatca ggaagaatgg gccttatgcc 2539741 gtttgcccaa atttcaaccc gtctcggcgg tgcaggcaca gttatttgcg cgacagtgct 2539801 gcttcgtttt ttcacttcat aaacagaaag agttccgttt tatgcggaac tcttttttta 2539861 tttattcaca atccgaatat actctcgggg accaaacggc agatcctttg attccgtctc 2539921 actcattctg gctgacaggt ggtgctccag taaatacagc tcccactcat cacaagccgc 2539981 cacaccgctg cgcccgtcat attgattcaa catgaatgcc cctgcaaata ctgagcagaa 2540041 taaacctgag cacatcacga cttttgtttt cacatgacca gctcctttcc ttcagcttga 2540101 tcaggattga ttttaaatat acaaataacc tcttttttgt tagacttatt ttgaggtcaa 2540161 aagaactcat aaaaatccat tacagcagtt cgaagcgtgg cagcttgcag aaaagtgcga 2540221 tataatttgg actaggtcgt ttgaccgtat attttataca tagcgcattt ttcaattgag 2540281 aacgagaaaa ggaggtctta tctttgcagc tcttacatct tgctatttta tcgccttttt 2540341 tatttgcttt tatcattccc ttcttggcaa aatacgcaaa aagagtgcat acgggctggt 2540401 ttgtgttgat cctgcccgtc ttgctgttta tatactttct cccaatgatc aggatgacgc 2540461 aatctggaga aacacttcga tcggtattag agtggattcc gtcactcggc attaacttta 2540521 ccgtttatat agacggcctc gggttattat tcgctttact gatcacaggc attggctctt 2540581 tggtcactct ttacagcatt ttttatttat cgaaagaaaa agaacagctt gggccctttt 2540641 atgtctactt attgatgttc atgggcgcca tgctcggcgt cgttctagta gacaatgtca 2540701 tggttctcta catgttctgg gagcttacaa gcctttcatc ctttttgctg atcggctatt 2540761 ggtataagcg ggaaaagtcg cgctatggcg cagccaaatc acttttgatt acggtcagcg 2540821 gcgggctgtg catgctcggc ggatttattc tcctttattt gataacggat tccttcagta 2540881 ttcgagagat ggttcaccag gttcaattaa ttgccggcca cgaattgttt atcccggcta 2540941 tgattctcat tttattaggg gcttttacga aatcggcgca atttcctttt tacatctggc 2541001 tccctgacgc gatggaagct ccgacgcctg tcagcgctta tctccattca gctactatgg 2541061 taaaagccgg catttatgtg attgcgagat tcagtcctat tttcgccttt tcagctcagt 2541121 ggttttggat cgtgtccctc gtcggcctct ttacgatggt ttggggttca ttccatgccg 2541181 tgaaacaaac tgatttaaaa tcgattttgg cgttttcaac cgtcagccag ctcggcatga 2541241 tcatctccat gctcggagtc agtgctgcgg cccttcatta cggacataca gaatattata 2541301 cagttgccgc tatggctgcc attttccatt tgatcaacca cgcaaccttt aaaggaagct 2541361 tgtttatggc agtcgggatt atcgatcacg aaacaggcac acgggatatc cggaagctag 2541421 gcggcctgat ggcgattatg ccgattactt ttaccatttc cttaatcggg acattttcaa 2541481 tggccggcct accgccgttt aacggatttt tgagtaaaga aatgtttttc acaagcatgc 2541541 ttcgcgtgac acattttgac ctgttcaacg tgcagacatg gggcgttctg ttccctcttt 2541601 tcgcctggat cggaagtgta tttacgttta tctacagcat gaaattgctg tttaaaacat 2541661 tcagaggaaa ttaccagcct gaacagcttg aaaaacaggc tcacgaagcg cctgtcggta 2541721 tgctcgttcc accggtcatt cttgtcgctt tggctgtcag tctcttcttt ttcccgaata 2541781 tattgtcgta cagcctgata gagcctgcga tgaactcaat ctatccgaca ctgcttgacg 2541841 gccatgagaa attccacgtt cacatttcac agtggcatgg ggttacaacg gaattgctca 2541901 tgactgcggg tattgttgtg atcggaacaa ttggttattt gtcgctgaat aagtggaaag 2541961 gaatctataa actgtttcct tcgaaactca cactcaaccg gttatacgat aagcttttga 2542021 ctatgatgga gaaaggctct taccgggtca caaaacaata tatgaccggg tttttaagag 2542081 attatttgct gtatatcttc gctggtttca tcattctgat aggcggagct tttgccatta 2542141 aaggcggatt ttcatttaaa acggaaggca tggctaaaat cggtgtatac gaaatcattt 2542201 tgacgcttgt catgatcagc gccacagtgg cgactgtttt tgctaggtca agactgacgg 2542261 cgatcattgc actcggtgtt gtcggttata cgcttgcatt gttttttgtc attttcagag 2542321 cgccggactt ggcattgact cagctcgtca ttgaaacgat ttctgtggca ctgtttctgc 2542381 tttgcttcta ccatttgccg aaactgaggc tgaaaacaaa aacgagaacg ttccggatga 2542441 cgaattttat catttcttta ggcgtcggtg ttatcgttac actgctcggc atcgcatcct 2542501 caagccagcg gacaaaagac agcattgcgt ccttctttgt caaacacagc cacgatctcg 2542561 gcggagggga taatgtcgtc aatgtcattc tcgttgattt caggggattt gatacaatgt 2542621 ttgaaattac ggtattaacg atagccgctc tcggcattta cagcatgatt aaaacaaaag 2542681 taaaagagga ggggaaaagc ggtgaatgaa caaaaaacaa atgacttgat tcttcaaacc 2542741 gcgacaaagc ttgtatcctt tatcattttg cttttctctt tctatttatt tttatcaggg 2542801 cataacgcgc ccggaggagg ctttgtcggc ggactgatca cgtcctcttc catcgttctc 2542861 ttgctcttgg catatgattt aaaaaccgtg cgttcccttt tgcctgtcaa tttcatttat 2542921 gtcgcgggag ccggccttct gctcgctgta ttaacaggcg ttggctcctt tgtcttcggg 2542981 gctccttttt taacccacac attcggatac tttcagctgc cgatccttgg gaaaacggag 2543041 ctcgccacag cgacgatatt tgatttaggc gtttatcttg ttgtcgtagg cataacgatg 2543101 accattattc aaacgattgg agaggaagaa taatggaaat cttaatggct gtattagccg 2543161 gtattatttt tatggctgct acgtatttgc tgctgtctaa aagcctgctt cgcgtcatta 2543221 tcggaacagc actgttaagc catggcgttc atttaatgct tttgactatg ggaggattaa 2543281 agaaaggcgc cgctccgatt ttgagcgagc atgccaaatc atttgtcgat ccgcttccgc 2543341 aagccctgat tttgaccgca attgtcattt cttttggcgt tacgtcattc atcctcgtca 2543401 tggcctttcg cgcttatcag gaattgaaat cggacgatat ggatcaaatg aggggaaatg 2543461 atcaacatga ataattttgt tattttgcca atcctgatcc cgcttttgtc ggctattctt 2543521 ctgattttca tgacgaagaa tcttatgctc atgagaatct tcagcacggc ggcatcggcc 2543581 atcgggattg tgattagcgg catacttgta cagactgtct tcacaaaagg catccagaca 2543641 ctcagcctag gcggatggaa agcgccgtac ggcattgtgc ttgccgcaga ccaattcgcc 2543701 agccttctcg ttctcacaac agcgatcatc ggtttattgg ttgggcttta ttccttccgt 2543761 tctgtcggtg aaaaacggga gcgctccttt tactactccg gcgttcagtt cttgcttgcc 2543821 ggcgtcagcg gagcgttttt aacaggcgat ttatttaata tgtacgtatt ttttgagctt 2543881 ctgcttattg cttcctatat gctgattgta ttaggcggca caaaaattca gctgcgggaa 2543941 tcccttaaat atattgtgtt taatattgta tcgtctgccc tgtttgtcat aggggtcggc 2544001 tttttatacg ctgtaaccgg tacgttaaac atggcggatc ttagcgtgaa aatcagcgaa 2544061 tcaggacaaa ccgggctgat cactgtgatt ggtgtcctgc tgcttttggt atttggcatg 2544121 aagggcggaa tcttccccct ctacttttgg cttccaggct cttattacgc gccaccggcg 2544181 gcaatctccg cgttgttcgg cgctttgctg acaaaagtcg ggttatatgc gattacgagg 2544241 gttttcacat tgatttttat tcacgataca gcctttaccc atcagttgat gatttggctg 2544301 gcggcgctga ctgtgatttt tggtgtgatc ggttcactcg cttattcgaa tgtcatgaaa 2544361 attgtgatct ataacattat taccgctgtc ggcgtgattt tgttcggtgt ggcagtacac 2544421 acccccgcat ccattcaggg cgcgatctac tatctgattc acgatatgct gattaagggc 2544481 gctttgttca tgctggcagg tacgctgatc gcattgactg gaaccgcgag cctgcataaa 2544541 atgggcgggc tgatcaaacg ctatcctgtt cttggatgga tgtttttcat ttccgctatt 2544601 tctcttgcag gcattccgcc actgagcgga tttgtcggca aatttaaaat tgcagagggc 2544661 ggcttcgcag aaggtgaatt tacgatatcc atgctgattc tgctttcgag tctgcttgta 2544721 ctgtactctg tgctgaggat ctttatacat gcgttttggg gcgaagaaaa agaaacgcca 2544781 aaaccaaatc atcgaacagc taaaggactt ctttatccgg cagctatttt tctcttgctg 2544841 tcccttctct tcggattggg tacagaatgg gtgtcgcctt acgttgatca agcggccgag 2544901 acgctgctga atccggaaaa atatatcgaa gctgttctga aggagtagat cgcatggcat 2544961 ttcaaatttt attaaatgtg tttctcgctt tttgctggat gttcttaagc aacagtccaa 2545021 gcgccgcagg attcattaca ggctatattc tgggaatgct ctctctcttt ttcttccggc 2545081 gctttttcac tcgccagttt tatctatgga aattgatttc tattatcaag ctctgtttca 2545141 tttttataaa ggaactgtac cttgccaatg tcagtgtgat gaaatcagtc ttatctccaa 2545201 aactgaatat cagaccgggt atttttgctt ttaaaactga actgacgaag gactgggaaa 2545261 tcaccatgct ttctctgctc attacattaa cgccgggaac cttggtgatg gatatttcag 2545321 atgacagaac aatactttat attcatgcaa tggatatcga ggatgcggaa aaagcgattt 2545381 ttgacattcg ggagtcattt gaaaaagcca tacaggaggt gagccggtga tgtttacgct 2545441 gatcctgcaa atcgcgctcg gcattatggc agtgtctacc tttttgtatg tcattcgtgt 2545501 cattaaaggt ccgactgtgc ctgaccgggt cgtggctctg gatgcaatcg gcatcaatct 2545561 gatcgcaatc acggcgcttg tctccatttt gctgaaaaca agtgcgtttt tggatattat 2545621 tttgttgctg gggattttat cgtttatcgg aacgatcgca ttttccaagt tcctggagaa 2545681 aggagagatt atcgaaaatg atcgaaaccg ctaaggtcgt tgtggctgta ttcattttgc 2545741 tgggtgctct tatatgcctc attgcttcat ttggcgtact tcgccttccc gatgtgttta 2545801 cacgcgctca tgctgcttct aaaggctcaa cattaggtgt caatatgatt ctgctcggtg 2545861 tcttcttcta tttgtggttt gtgacggggg agctctccgc taaaatcctg cttgggattc 2545921 tctttatctt tattacgtcg cctatcggcg ggcacttgat ctgccgtgct gcgtataact 2545981 ccggcgtcaa gcttgatgag agaagtgtgc aagatgacta taacggaatc agaaactttg 2546041 tgattaaacg aaaagaggat tcttatttat aaaaataagc agccggacag gcagagttcc 2546101 ggctgttttt ttatttcttg atgacagcca gcgtgcatct ggatatacag atcagcctct 2546161 cttgctcgtc atatatgtga atatgataga caatcgtcgt tctgcctata tgaacgggct 2546221 cggctatcgc ctttaccgtt ccttccttta cagattttaa atggttggcg ttaatctcca 2546281 aaccaacaca agcttgcgtt gtatgatcaa tcaggttctg tgcacctgcg ctcgccgcgg 2546341 tttccgccag ggccactgaa gcgcctccat gcaaatatcc gaacggctgt accgtccgat 2546401 gatccaccgg catgaccgca acgcatcgtt ccgctgtgtt ttcaacaatc tcaataccaa 2546461 gcgcttcaag caatgtgtgc ttcatatcca tctctacacc ccccaacatg aattctttct 2546521 ccttgatccg gacagaatct aaacatatct gctcaataac gacttccccc ctcccattcc 2546581 attttactaa atgggacatt taaaggacag caggtttttc gttttttaac aatcatataa 2546641 tactttatcc atttattgta tcggtagaac gaaaaaaaag acttgtttcc aagtcttttt 2546701 cacgaaattt tcattgcata attgtattta tcgagttgat caatgctttt gttaatgttt 2546761 cgtaatgaat ctgtcgtttc tttaatatca agttcgagtc ggaataacaa ttgttttact 2546821 tcttcaagtt tcttttccat cgtttccaca ctcctttttt tgaaagatca atgaattgtg 2546881 tatggtgaac gagtcctagg tatttgatct gttactaata gtgtgtctgc tttcggctca 2546941 tttttcaccg aaaagtatgc aaaaaagtcc tgcgtgacac cgcaaatctc aataggtcct 2547001 tatactcaaa ggaatcacaa caagaacggg actatctttc tatgcgaaag agcgtttata 2547061 tgtgctgaaa ttgagaaaga ttcttaatct ccttgatttt aacgggtttc gcattttcac 2547121 taagcaagac tatagtcctt cataccgtat tttcaaaatt gaatatgcga ttcttggcgt 2547181 ttcctgaccg acaaacaccg aaaaagaccg caacgctaaa gttgtggcct tttcgctttg 2547241 tcatattcgg caattaggga tctatacata tagaaacatc cttttttgcg aggtgctccc 2547301 atgagatatc gttatccctg gttttacgtg tatccgtatg aggtacgccg tccgcccgct 2547361 cctgccaaca atattgatac ctttatccgt tcagcgaagc aggccgcagg gatatttgcg 2547421 gatgcccagc tcgttctcag ccgcattgcg ggctcgcggg agctttcgcg ccgcattctg 2547481 accgcagccg aacagtctga taaacaaact ataaggcgcc tgatcaaaca aatgggcgtc 2547541 cggcatgaag tggatacggt ctttaatccc gacggcatct atatcagcct tatcggaacg 2547601 caaagccgaa tgattcttgc tttgcggtgg tcagaggacc gcaatcattt tgcgtccata 2547661 agattatgac accattccag agcctctaaa taacattcat acgcttcttc tttgtccagt 2547721 tgattgccta attctgagca agtgtcccag ttgttgcttt caattaattt cacaagctca 2547781 agcatttggt agtagtcgtt ttgatggcct aataatgctt gcccgacttc atcttttaaa 2547841 ggcaattctt gaacaatttc ctctatttct ctatgcagga gggtgtctat gagagaaaac 2547901 attccgatca gcatataaga agcaggctgc ggccgggatg tctttctcgc cagcagttcg 2547961 caaagctttg ctcttatcag agaaatctta atgatttcgt gcttgctgga atgccctttc 2548021 ctgcttaaat ccttaaagga aagaatatat atccaccgtt tgatttcatt aaatcccagc 2548081 agcataatgg cctgttgaat gctttcaatt ttctggctca aacggctgtg ggatgagttt 2548141 aaaaatttta aaatttgata ggacagtgat aaatcccgct ctatgtactc tgtcacacgc 2548201 tttatgttag gctgctcttt actcagttcg ttaagcagtt catagtaaga atagaaatga 2548261 gtcgataggt catgcccgct gatgatgcgc ggctcgctga aaaagtagcc ttggaataat 2548321 tgaaagccgt cttggaccgc ctgtttatat tcttttcggg tctctacttt ttccgctaaa 2548381 aaaatcaggc cgcggcagcc gtaggtttgc aaaattgttc tgcgttccat tcgtgttgtt 2548441 ttgagaaaat caattttcaa tatatcaata tagctcatga gtttttccag taagtcctca 2548501 tcttgcggat ttattgcata aaaatcatca agcgccagca tataccccat ttttttcaat 2548561 tctttgcatc tagaaatgag ggccggcgtg atcggtatat cttcaaggat ttcaatgaca 2548621 agctgtttcg gattgaagga ggtgggaaga ttcgaaaaca tcaggctttc cgtaaaatta 2548681 acaaaacagc gtttcccttc cgtcagcttc tcaattccga tgtttaaaaa gctgttgatc 2548741 accaaatctg ttgttgcctg atcgccgtct ttagcgctat acacgttctc ttcgctttct 2548801 ctatacagca gttcataagc aacaacctgt tcttttctat taaaaatagg ctgtcttgca 2548861 acaaacaccc tcattgattt atccccctta caatacgcgc ggctttcacc cctaagtata 2548921 tcaaataatt tgacgaaaat tgtctaaaca tgaaaaataa tatatacata aagaaaactg 2548981 gcccttcgcg aatgaaaggc cagtttttct ttattcttcc tcaagctctt cttcaattct 2549041 gcttttcact tcgtggatcc gctgcatttt attgctccag cagtcctcgc ttaaatcaac 2549101 cgggtattcc tccggcttgc tgattctctt atattcctcc caaagcaggc tgaggttatc 2549161 ctgcacatac tgctgtatgt ctgaaatctc agggttttgg tagcaaagaa tacccttctc 2549221 aaaaatcagt tcatgaagat ccttcgcata aaaattcgtg acaaatttgc tgatgaatgt 2549281 atgaaccggg tggaacattc tgagccgctt ctgatcattc acctgctcat cataaagcgc 2549341 aatatagtcg ccttcagaat gatggttgga ctgattaata atgcggtaga ctttctttct 2549401 gcccggtgtc gtcacttttt caggattgga cgaaattttg atcgtgtcga ccattttccc 2549461 gtcttcttca atggcaacga gtttataaac tgcgccgaga gccggctggt cataggcagt 2549521 gatcagcttc gtaccgacac cccagacatc aatgcgcgct ccctgagcct ttaaattcat 2549581 aatggtgtgc tcatccaaat cgcttgaagc aatcaccttc gcatctgtaa atcctgcttc 2549641 atcaagcatt ttccgggctt tttttgacag gtacgccaaa tcgccgctgt ccagacggat 2549701 gccaatgaaa ttaatgcggt cgccgaattc cttggcaacc ctaatcgcgt tcggcatgcc 2549761 tgaacgaagc gtgtcatacg tgtcaactaa gaagacgcaa tccttatgtg tttccgcgta 2549821 ttttttgaaa gctgtatatt catcgcggta agcctgcaca agcgcatgcg catgtgtgcc 2549881 ggaaaccggg atattaaagc gctttccggc tcttacattg cttgtcgcgc taaagccgcc 2549941 gattaaggct gctctcgctc cccacatggc cgcatccatt tcgtgcgccc gtcttgttcc 2550001 gaattcaagc gcaacttcat caccgatgac gcctttaatc cgggcagcct ttgttgcgat 2550061 taatgtttga tagttcacaa tgttgagcaa agctgtttca atcagctgcg cttctaccag 2550121 gggtgcctcc accctcataa tcggctcatt gttaaaaacg agttctcctt ctttcatgga 2550181 gtaaagtgaa cctgtaaaag ataagccgcg caaatattca ataaaatctt catgataccc 2550241 gagttcatcc tgtaaataac tcaaatcgct atccgtaaac ttgaaatttt ccaagtattc 2550301 aatggctttt tccaagcccg caaatacggc atagccattt tcaaacggaa gccttctgaa 2550361 aaacagctca aaaatcgctt tcttttcatg aatgccgtct ctccagtacg tttccgccat 2550421 attgatctga taaaggtctg tatgtaatga caggctgtca tctttaaatc cgtactctaa 2550481 cactgttttt ccccttcctt actctgccac ttgcgctccg atgctgtttg caaaatggga 2550541 aagagcccat gcgtgcccct cctgattaaa gctggcaaca gcttgtttat gcacaacaat 2550601 ccgaaaacct ttgttgtatg cgtcaacagc tgtatgcaac acacaaatat ctgtgcagac 2550661 accggcaaga tgcagttcgc caatctgccg ctctctgagt ttgagctcta aatcagttcc 2550721 cgcaaaagca gaatatctcg ttttttccat gtagtaaaca ttaggttcat gttcatgttt 2550781 ctgatataga ggcaaaagct ttccgtacag atcttttcct tccgtgcctt ttatattatg 2550841 cggaggaaaa agacgggttt cagggtgata ttgatcccct tcatcatgag aatctactgc 2550901 taatacgacg taatcaccgt ttgtgatgaa ttctttagtt aaattgacga tcgcctcttc 2550961 aatcattctg ccgggctccc cgcaggtcaa ttttccgtca ctcgccacaa aatcattcgt 2551021 ataatcaata caaataagtg cttttttcat agccggcctc cccgccatca gtatgagaac 2551081 attatatctt atctccagtt gtaagtgaat tgccatgaac aaaaagacaa acggtccgtt 2551141 tgtctcttac gatttcagta ctgaccgatt ataaatgtcg tcctgaatat atatcaattc 2551201 acgattcaca gcgatatcag ccgcaatgac gatgcctaag ggcgtatgaa actggagatc 2551261 agatacaatc ttgaaaggca ctccgtaccg gctcgccatt tggatataag aagagtaaga 2551321 ctgatactga agctctccat taatcaaaag ggtgacgtta tggctgtttt tcagctcgtg 2551381 ctctgcctct ttatacggtt tgcttctaag cacctgtcct ttcgtcagtg ccaaaacgac 2551441 tctttctctt aaagagccta aaaacaaatg gcgctcgtca ggctttgtct ccaaaggccc 2551501 atacattcct tgctgcaaat agagatccat tttatcttca ctcaaaagcc tgtcctcccg 2551561 tcttgtttgt cttcattatc acctgatcag gcaggagcta aactttcaag cgccgtttac 2551621 atttctgtta cccaatgaat gatttttttg gccagctcac cagcaggggt ttcctctgta 2551681 tgccggcgca acgacgcttc cagccgttca ggcagagttg ctttatcttc ttcataggaa 2551741 atgatcgtgc tccactccag ctgcggtacc gctacaagcg tgcgcagttc ttttctgttt 2551801 tcatgcagat acacgtccgt gatcattccg gtttgcgtat tgatatttgc ttttctgatt 2551861 ttcataacat gacctctcta ttcaaagact acccatatta tacaataaaa aagcaacagc 2551921 ctcttgtgaa aaggctgtta cccgttaaac gaaactgttt catcagtgat atcggcatct 2551981 ttgaagagag ttttactcgt ttggttgtta atcttcacaa aatcaccaag ctgaaatgtg 2552041 cctgaccccg cccctgaatg agcgacgctt ttgggcgaaa tcgcaaatac gtctccaaag 2552101 cttgccgcgg cattatccgt aactgacatg atataaatcg gccccacaat tgcaggcatt 2552161 tccccacctc cgcattgatt tacagcatca tatgcaagga gccgataatg gtgcccgcct 2552221 attcagctgg ctttgcgttt tcctcgagtc gtgaccgctg gcgcagcttg atcaagcgga 2552281 caatattcag gaagaacgcc ttcactaccg cataaaccgg caccgctaaa atcatgccga 2552341 gaattccgcc gaagcttccc gctccgatta atagcaaaat aatcgtaagc ggatgggtat 2552401 tcagccgctt tccgatcaca agaggagaca gcaggtttcc gtccagctgc tgaacgatga 2552461 cgaccacaat aatcgcaaac agcgctttgg ccggcgagtc cataaaaccg acaatgacag 2552521 ccggcgcggc accgagaaaa ggcccgacat agggaatgat attggtaatc gccatgacaa 2552581 tcccaagaat cagggcatac ggcagtccgg caattaaata gccgataaaa cacgctgttc 2552641 cgacaaaaag acagattaac agctgcccct ggaaatatgc cgcaagcgta tcggataaat 2552701 ctttaaaaat ctttaagcct tctgtccgat aagaagccgg tagaattttt actgccaaat 2552761 gcggaaagcg gtgtccgtct ttcagcatgt aaaaaaggat aaatggaaca gtaataataa 2552821 caagcgtgat gtttgtcacg acaccaaaca ccgcagataa actggacgtg atattttgcg 2552881 gcaggttttg gagaaaactt gtcaatgact gttcaatttt tgatatcgat acataatcct 2552941 ggttcatcat ccaggtaaac cattgagaat gggacaaatc ctttgtcagc gcctgaatct 2553001 gttttatata atcaggaagg ttgttaaaca gccctgtcac ctgtgcggtg atgataggtc 2553061 cgactgacgc tgaaataaag gcaagcaaac cgataaacag taaatagatc aatagaatgg 2553121 ataatgtccg cggaattttt ttctcaagca ggcggacgac cggattaaat atgaaataca 2553181 aaattcccgc aattagcatc gggaaaaaca atgtcgagat aaaaacaata aacggctgaa 2553241 atacaaatga aacttttgtt gctacaaaaa taatcagcaa aacaaataaa atctgcaatg 2553301 tccaaaaatg gacttttgat ttcaacaagc tttgttcctc ctagtttttc tttgtctgtc 2553361 agataaaaga acttataccc catcattgta acaaaaatga actcatatca gaactcttaa 2553421 tataatgaaa ggagtgttgg tgatgaaggc cgtgacatac gatacagatt cagaactggc 2553481 ttatatctat gttcttcctc cgaaaaagaa caggaatgta cggactgagg agctcagagt 2553541 caatgattgt ctcctgctgg atatcagcca agatggcaaa atcgccggat tcgaatgttt 2553601 tggtgaggca gcacacctct gtgccccatt tgccgggaaa tcccggctgt atgtaaaaga 2553661 ttcagacggt tatcattttc gggtctgcca gcatgcttca gtccgttcct gctatacggt 2553721 gtaccgtgtc actttctgtt tttcagatgg tgactatcag gaatttgccg gctttgacct 2553781 tgatggaaca atgtatcata gtgcgttttt acagcgctta actgaaaaat aggacgtcct 2553841 gttgtacgcc tatttttcat gcgcaagcac tgttagaccc gctcactgta atctggggtg 2553901 acggaaatca tgtgctggat tctgatcaaa caaacagaat ttcgggctcc ttcaattgtg 2553961 atatggtcag gttttacatc gatcagtctg cctctgaccg tatctcgtac tgtctgtata 2554021 acgaaccttg agccgatgag ctttttaatg gtctgataga cataaggatc gactaaagag 2554081 accagttgcg gactaccttg gttgaccata cttttatccc ctttgtgtgt tttatctcag 2554141 cttatgccgc gcttatggat aatgacacag gcttacctga taaaacaaag gggtgcggag 2554201 attttaggag aatacgtttg gaggcgggtg taaaggaagt atcgatgaag cggagacagc 2554261 gaagaaagct ggcgctgttc cgtacttata caggctttat cacggatgcc tgggcttggt 2554321 cgattaattg gtccagcttt tctatttttt ttcgtgcggt tgaaggatca atttggcggt 2554381 aatgatggtg gccgcccggc tcttcatcca gttcgtccgc ttttttgaca atctgctgca 2554441 gtgtgttttt atctaattcg ccttcaggca aataggaatc tgtatgaagc aaaatggcta 2554501 gtgcaatctc ttttgctgct ttcggttcct cgccaagccg aatcagaagt ttatgcgccc 2554561 gttccgcccc tttaatggca tgaatgtcat ttcttttgta tttctcataa tcccactttc 2554621 cgtctgtata ccattcataa tggccaatgt catgaagcag tgccgctttt gctgctaaat 2554681 caggattaat gtcagccttc acagacagcc tgtatgcatg ataagcgcag gcaatcgcat 2554741 gtgccacgcc ggaacgctga agatattttt gtgcaattgg atgggtgaaa acatccatta 2554801 atgtaacctt tctcatggaa acccctcctt tagatatttt tagaatccta acataatttg 2554861 cagagaaact caattcttat gtcacatcat tttgatcttc ttatcatcat tgttataccc 2554921 taaaagcaac gtttcagtca gtatatgcgg ctgttcaata aaatgcgctg gctgcagcct 2554981 tttgtataaa aaaaagagca gaaaatatct gctctacaaa aactctttaa tatcataaat 2555041 gcggccgttt tccgtccctt tttctagtaa agaaagcagc gtgccggcaa taaagtccgg 2555101 actgcgaagg cttcctgttt catttaattt ccggaatcgt tcaatgtggt ggaaatcctt 2555161 tttcgatgaa gaacggatga cggcctgcat ctcagtgtcc atcactccag gtgagaacga 2555221 aatcatgttc accggcagct cttcatcctc ctgttcaaat ccgaatgtcc tcgtaaacat 2555281 gtcgagcccg gcttttgaac tgcaatacgc gctccatccc ttatatggat ttttggcggc 2555341 tcctgaagta atgttgacaa ccgtcttttt gccgctgtat gaagcaaacc gttttgtaaa 2555401 cagctgactc aaaagcacgg gcgcagtcag gttcagctga taatggcgct gaagctcgtc 2555461 aagagacgct tcgccggcac gtttgatcgg cgttaccatt ccggcgttat taataagggt 2555521 aataccagaa taacgatctg aatcgatgga tgagagcaat gtttcaaatt gctgttcagc 2555581 ttcttcgaga ttgatgaggt ctatttgatg ctgcgttagt tttttgtgag agacatctgt 2555641 tttcgttctg gataaggcat ggacttcatg ccccttttct aaagcctgta atgcaatggc 2555701 ttgacccagc ccttttgacg ctccggtgat gatataaagt tccattggaa acctcctttt 2555761 ccgttattat tgtacggcac ctcttttaca caacacaagc acgcggccta cgccttcttg 2555821 ttttcctgcg ctgtgacttt tgggatgagg aacacgatgc ctgcaattcc gagcaggatc 2555881 agtacgacat agatcatcgg cagcagcaat gatgatgttt cttgttcatc ttctgtttcc 2555941 gttgatgatg tctttgtcat tggtttttca gcaaaagtaa ttccaagctg tttcgactgg 2556001 gccgcaatcg tgttggaatc ctcggcattt gttgatgtaa acaaatcttt tatcagctcg 2556061 gcgtccttgt ccttcggttt atcaaaagtg atatcctttt gttcctcagg cagttctgtt 2556121 ttttcttcat agtaggtatc ttcatgcaaa taattcgtat cgatttcgat gtcttttttc 2556181 tcatactggt ttggcgcgac atctgtattt tcttcagttt gggcagccgc tgcagagggt 2556241 atgaaaaggg aaaaggagag catacaaatc atgatcccct tttccatgct gcgatcacgc 2556301 ttcatacgtt tcatcgcttt ctgctgtgtg ttcagccatc aaccggataa tcagcggcag 2556361 agccacggca atcaccgtaa tgatcagcag aactgttatt cccattgtaa acaagtgccc 2556421 agtaccgtac tggatgtcga tatatacttt cgaaaccgga tcttcaaatg taaagttcgg 2556481 catgatcaaa tcaataagcg gtgcgacata gaataggatc attgctgctg aagcaaccca 2556541 gccagggatt gatccgaatc tgaatgccgt ccggatgaag gcagagcttg cgaccagcaa 2556601 tagaatcgta aacaccgacc acttaatcgt ctgatcgtcc ggcagtgaat aaatattcaa 2556661 gccgaacaag ctgatcataa gtccgacaag gatattcaga attccgaata acgctccttt 2556721 gacgagaagc ggtgcgtttt ggtaatacga gctgaaatag ccgattaaca gactgctgat 2556781 caacacaatg acaaggatga caaccggagg taccgtctga attttttctt ccggaacctc 2556841 tccgctgatt ttaagcggat tcgctaagta atcatataca tagccattgt tttgcccgtc 2556901 tactaatgta tttccgagta tgccgtatac gtcatttcgc acgagtttcg tggaggcgac 2556961 atttttcccc cagttgttgt ttaaggtgtc ggctttcgct tgaacatcat taacgctttg 2557021 ctgcatgttg gttgtgtaat caatgatgcc ggactggcga tcagacaatg aacccatcat 2557081 gtctgacatt tgcagcactt cctggccgac cgtatcttgg acactcagtg ccatggtacc 2557141 agacagccca tcgttgctga acgtcgcaga ttcctgtgtt gcgcccgtta caagctgttc 2557201 tgacgctttt gcggcacttt cagagatttt cgtcagttcg tcgagaacac ctgcttgaga 2557261 gtcacggata tagccgctgt agtcgtccgc aaatttggtc atgccgtcga tgaagctgtt 2557321 aatatcctca tctgtttgca tcgtgttgtt tttgagagct tcccagctgg ctgattcttc 2557381 aggtgtgaga gccaggactg attggacgtt gccatcttgc tcttggatga cttcaccttt 2557441 aataatagtc aaagagccta gatccagatt atcatttagc gtagacttat ataaatttaa 2557501 agagttgtaa tacttcatca agttagaaat attatcagtt tcaattctac ttgaaaaaat 2557561 tgaacttagt ttttctttct gatctatata gcctctactc tgcaaagttt gtattatttc 2557621 gtcttccaaa ttgtatatta acctataagc atcattgaca ttattatcaa aatcaaccaa 2557681 cttttttgtt aagtcaccaa tttgatcatt taattttgaa actgttttat ttaactcttt 2557741 aatttcttga tttaactcat caatatgttt ctctagtttg ttgttatgtt cctcttgttt 2557801 ttcttgaagt gcattttcta tttcctctaa ttttatcgct gcttcgttca gacgtttttt 2557861 tgcacctgaa atatcagttt caccgtcagc tccgtcaccc tgtagcccat cactttgatt 2557921 tgagccatcg ttttcatctg cgagttcaat caaagagaaa tctgttttag aggttcctgt 2557981 attctccgtg tttgtatctt gttcaggaac gttttttgaa gattcttgat gtttttgtcc 2558041 cgtttcaatg ttagtttgaa catcattttg tgatccatta tcttgagtac cctcttctga 2558101 tgagccagta tcttcatttg ttggctgatc atcggatgtt ggaatatcat tcgacggttc 2558161 ttcagtatta ggagaatcat cggttgatgg ttcttcagca tcgggtgttg ttggtttttc 2558221 ttgttcaggt tcttttaacc cttcagagat atctttaatt tcagttgcaa catttttgag 2558281 ctcatcccgc tgcttctcta aatccaattt tatatcttca atatcttcct tatctgtgtc 2558341 atctttatta tcagatgtgt cttctccatc ttccttttcg tcgctttcct taggtttaag 2558401 taaactaagg cggttcttcc cgatattctc ttgcaattga tttaaatttt gatatttaat 2558461 agcttcatat tgacttttat atcgagatag aaatgcatta aacatgtcat tctcaatttt 2558521 tttcataccc atttcttgca atggcacttg attttgcctt aacttttcag cattgttcaa 2558581 cgcaaggttt gtcagtccta tttgtgtctt cgcttggccg atcccggttg ccaatccgct 2558641 catgcgttcg ctgaactgat tcgccttttg ctgtgcctgg atggcatcca gacctgtccg 2558701 gatttgctgc tgtgttgaat cctgggctgc caaaagcagc tttttctgat tctcttgata 2558761 ttctttgtac ctttcaactg tatcaatgaa ttctttcagc gtgtttttgg cttcctccgc 2558821 cgtagaagct ttttcttttg tcgtgccttg cgcttcattc attgatttct tcagctcatc 2558881 gattaagtct ttttgctgtt tgatttcacc tgctaaatca ttagagcttg gtttgtaaaa 2558941 gttgtacatg acattctgga attcagattc tttattgacg atcttgtcaa attctcctct 2559001 gatgttgtcc actttttgcg aaacaaaatt ccagtataag gccgacattt ttttgttcat 2559061 tgtcttttgg gcatcctcaa gctcacgctg aactttttct ttgttaaccg cattcaggtt 2559121 atcttgaatg ctgaattcga gcgttgcctt ttgaggatgg tctttgtcat agctcaaaat 2559181 gttttttgag aagtctgagg gaatgtagac aatcgcatcg tatttctttg aagcgagacc 2559241 ggtctcggcc gcgcttcggt ttacgaccgt ccacgaataa tcaggacgtt cacccagaac 2559301 ggccgctact tccttgccga actgggcgga tttgtcctct tcatcagact ttacctcatc 2559361 actcaatacg cctgtgtctt cattcaccac cgcgatttgc cgggtagaat tgactgcttt 2559421 tttcgttggg tcgtctccga taaatcggaa aaacaacacc ggcagcagca aaatgatgat 2559481 gacggcggat attaacttga tcaagctttt tcgttgttct gtcatctagc actctccctt 2559541 tcagcagaac ataaaggaat ttgaactttt tgctccttcc cgttttccac aacatatccg 2559601 aagcccggct gaatctcagg ctcctgtctt tggtacggga gaggaatgac attttgctca 2559661 gactttttca tcagcagaat cgcgtggcgg atttgcttca tctcagtcgt caaggagtca 2559721 tagccttttg agaattcgct gtggtttccg cccgggataa agctgaaccc aagatgagcg 2559781 tatgatttca tgaagttagc gagacgatct tgtattctcg tatcaatcgt ctgctggaat 2559841 ctcgttatcc cgtcaatcat cagcacgact tgtgagaatc gcagattttg tgcgtctcct 2559901 tggcggacgg cttctacata catggcttct cttgttttga aaatgtcttc tgctgtttca 2559961 atccactgct caatatcttc tttcgtttcc aaatatgaaa catctgattc cttcgcataa 2560021 tgagataagc cgcggtcaat cgagtcaaac aggccgatca tttcggtttc atcatcaatc 2560081 agatgttcaa gcatgacttt taggacgttt gttttcccgc gctgagtttg gcctaaaatc 2560141 aggcagtgct tatgcttgcc caaatcaaaa tagactgggc tgactgtttc ttcatgaagc 2560201 ccgatcggta cagataaagg cttgcgttcc agcttgaagc ggatagacaa ttctctcgtc 2560261 gacaagctct caggcagcat cggaatcggt gccggctgct ccattgaagc aaatcgccct 2560321 tgaagtttct gtacgtctga tttcagctcg ttgaacatgc cgatatcatc atcggcgtca 2560381 acaggcagga acatttgcgc gaaataaagc tcttcctttt gaatgatgac gcgtcccgga 2560441 atcggctcaa gattgaattt cggacggccg taaatggaat atccttctga ttgatccatg 2560501 agataatgga caatctttgt tttcaagtta tttaacaatg actggcggac agcattcacc 2560561 cgcgttgctg tcagcataaa gtagataccc aagctttgtc cgtctctgga aagctggaca 2560621 aattccgatt caagctcatg catctcatcc ttgacaatgt caaagttgtc aatggtgata 2560681 aaaatgaatg gaagctcttc ttcgctcagc gcattgtaca ttttgatgtg gctgatttct 2560741 ttttcccgga acaaacgttt acggcggtca atttcttctt tgatgcgaat catgaacttt 2560801 tcaattttcc ttgactggtc catcaggaag taatccgcgg tatgcgggag cttcgctaat 2560861 ggcagcagcg ttccgtttcc gaaatcaaag atatagacat gaagctcttc aggtgtgtat 2560921 acgtccgcaa aactcatcag gaacgttgcg gctgcaatcg attttccgta gcccgaagag 2560981 ccgaagatgc cgatatttcc atcttccatc atcttataag caattggcgc ctgtctttgc 2561041 agatcaggtt catcgacata cgcaaagtgg aaatggtctt tttcgtttga agggaaaaga 2561101 gtgcgcggaa tacgttccgc aagcggcggc agccaagggc ttggcagctt ctcgattccc 2561161 atttcatctt ggatgcgttc aatttcgtca actacagctt cgatttcggt ttgaacgtct 2561221 tttttcgcgt tatcttcggt atcaacctca gaaagcggga tcagacccgt atctgtgacg 2561281 atcgcgattt catcctcggt accgtagact tcctctaagt aaggcgcccc gctccatgca 2561341 gattggaaca gctcatacac ttcattgttt ccgacctgca aatagccgcg gcctgttacg 2561401 gtaatgtttg cggcatcgct gtttttcaaa atttctttac tgtcggtggc atcctggacc 2561461 ttgagcgcta ctttaaagcg cgagttactc cagatctggt cgtcgatgat gccgcctggc 2561521 ttctgtgtcg ccaaaatcaa atgaacgccg aggcttcgtc cgatacgcgc ggcactgaca 2561581 agctccctga taaaatcagg ctcctcgctt ttcagctcgg caaactcatc agaaattaag 2561641 aacaagtgag gcatcgccac ttctgctttc ccttgcttgt atagctttgt atagtcattg 2561701 atgtgattga cttgatactg gtcaaacagg cgctgccttt tttttagctc gcttttaatg 2561761 gaagcaagcg cacgcatact gaagtttttg cttccttcaa tatttgtgat cgtgccgagg 2561821 aggtggggaa tgttacggaa cggctgcgcc attcctccgc ctttatagtc aattagtaag 2561881 aaagccgctt catgcggatg aaaatgcact gcaagtgaca agatgtaggt ctggagaaat 2561941 tcacttttcc ctgatcccgt tgtccccgca agcaagccgt gcggaccgtg tgctttttcg 2562001 tgaaggttca gatacacaat gtcatctttc cctttatagc cgatcggcac tgacagcgac 2562061 ttcgacgatt cacttgtcag ccatctttgc tgaatgccga tttcttttac ttccttcgca 2562121 tgaaaaagct ccaggaacga taccgtttcc ggaatggaat tcgtaatgcc gacctggtgg 2562181 ttcagcgtcc gcagtgtgcg tgaaaaccgt tcgttatcct cacgctgatg atgatcgaga 2562241 cggaacggaa ttcttaccgc ttttttcttt tgtattaaaa tgtcgccttc atgctcatta 2562301 atgtagcgga caagagttgt aatgttttcc gacaagcttt cctttgtttc tgcagcgaca 2562361 attgtcgaga tgcccagatg ctcatgctgc ccttctaaat attcgagaat gacatgctca 2562421 gagatcagct gctgattcgt gatgacaaat acaaaatgcg gtttgaactg cagtttttct 2562481 ttgtcatctt cgagatcacg ctctctgatc aattcgtaaa gtgaagacag gagctgatct 2562541 cgggtttgct cattataaat aaatcctttt gcataaatat ggggcatttg aaattgcgga 2562601 agccacttca tccactccca gtctttatac tcttcttcat gaaaaataaa tacgaaacgc 2562661 aaatcgtgat agctgttaaa gaacgacagc tgtccgatta gctggtgaat ctcatttttc 2562721 acaatttgtg atttaccgac aagccccatc ggaccttctg ccaaatcgac cgtcaccggc 2562781 gcattacgga tatctttata gacgcgttgc atgtgctgcg atttctccat gaggtcatcg 2562841 atatcacgat tcgccaagtc tccgccactc atattgattt catagcttga cggaactgtt 2562901 cccgtcccaa gccgcagctg gagataatcc ttgctttcaa gtgatttttc ccagatccgg 2562961 tcactgattt cacttgttaa gtatttcatt tgttcaaatg aaggaaagtg aaattcaaga 2563021 acctgctttt gcttttcagc aagtgcctga agctctttcc gcttattgtc taagtaaagc 2563081 ttatatacac gctcccgttt ttcctcgcgt tttttccgct ggtttttatc acggaaatat 2563141 tgcactgtcg aggtaatgag agtcatcata aacatcgcca aagaaacgag tataaatatg 2563201 ccgcgcggct ggatgatggc aactacgccc atcacgatca gcatcacaag cggaggcagg 2563261 atgacgagcc acagccctct gttggtttga tcgctctcct gagagggaaa actgaaagaa 2563321 acgcggtcat ccggcagatc gtataccatc cgcggcgttc ttctgtactg cggatatttt 2563381 ttctgcatct ctgtactcgg tttgaccgtt tctgttaacg ctgtttcaaa ctgggcataa 2563441 tgaacaattt ctaaaaggtc ttgttccgtc accctcattt gcgtgaagtt ccagaatatt 2563501 tcatcccccg gcttgagcgg cgtattggcg ttgattttct ctccgttcaa gaagatcgtt 2563561 ccgctttcag ggcggaccga ccagctgccg cctgcacgga gcaaagaaaa cgtgctttgt 2563621 tctgcaaatg caaaatcttg cggattcaga taaatatctg cattcgtttt ttctgaggaa 2563681 catacaattt catcccgatt tcccgtaaaa taaacggatt tctcaggttc actgcccgtc 2563741 aatatcaagc gtatatcctg ctgatccgtt tggagagtaa atgatatatc cgtctcaatc 2563801 gtgccgagac aatcatttcc caggaaaact tcgtattggc cgccggattc ctttctttta 2563861 agagaaatca ctccgctatt aaatggaatg gtgctgatcg taacagaatc cttcacatca 2563921 ggccctatgg tcaccggatg agacgacggg aggttagaca gatttaattt ttgaacgtta 2563981 ttttggtaaa aaacccataa tagactcaaa tggcgaaccc ccttacggcc gaatggcagc 2564041 atgcgatgac ctgcgcttca tgtctcacgt tatttgtcat cttttttctc atctttcttt 2564101 tctgtttctt ttttctcgtc ttctttttcc ttctgttctt cttttttcgc tttttcctcg 2564161 gctgcggctt tttcttctgc cgctttctct tctgcttgtt tttcttcgtc tgtttgtgtc 2564221 tgttcttcgc ttgtatcgac taacgatgtt tcagaattag actgtttatt ttcttgacgt 2564281 tctttttggg ctttttcaag ctcactattt actgaatcaa gttctttttg tatgtcttca 2564341 tcatttgtat cctcagataa aagctgctgt ttatatttag ctagggcaaa gtaaatataa 2564401 tcattgtatt ccagcttacg gccgatactg atcgcttctt tgtattctcc tcgaccataa 2564461 tcaatccaat ataagaaatg ctgagggtct gattgaaggg tgactaaatt attttctata 2564521 tttttggttt ttgcactccc caggttttcg acctcaacat aggacgtcgc cagctgatac 2564581 tgcaccgatt caggcaggct ttccgcatcg tacttggaca gtgtgctgat gacttcactg 2564641 tactgcttgt ttaagaacgc acggttgctg tccactatcg cctggtgctt tggctgcgcg 2564701 aaaaataagg cgtacatcga ataaataagt gccggtacaa gcaaaacaat gagccccagg 2564761 ccgatatatc gctggatgtt ccacttcttt ctcgggatat gtatgtatgt ttttgctttg 2564821 gcttcgagct catcaatatg ggtttgaatc agctcgagca aatcatcata ggattcagca 2564881 tctaatatcg cctttgcctc tgcggagaac gtcagcgttt cattgaattt caggtagtct 2564941 tcaaacgcaa aagcgccgtc aactgccaaa gccgctgccg ctttcagctc ctgccatact 2565001 ctttcctcat cacgctcgta aggaggaatg ctttctttta ctccataatg gagaaaataa 2565061 ggcgtaagcc ctttatcgaa tacaatgttt tcaggagcga caatcaaatt cagcctcgac 2565121 agattgtgct gctgtacggc ttgaacaagc tgataggcaa actgccattt acttttttta 2565181 tccttagctt tcatgaagcg gaatgcttta taggaggagg gaggttggat tgtgatgatt 2565241 acttcatcat ccgtcacatc gatttcttta tgaaaaaatg gatttatatc tttgatcacg 2565301 ttagcttcaa gaccgtcgag aagctttatt ttttcccgtt gaaaggtaaa tgtatagccg 2565361 gcatctgttt tctcggcaac agcttctaat tggttttcta aatatgattt ttgttcacct 2565421 gacattcaac cagatccttt cataatattt caagccggtc tccgtttgta atgccgcaat 2565481 cagacagctt gcattctccg gaaaacacct tatccttgtt caccactctg atccagtgcc 2565541 cttcgcgcgg aggcatagat acgctttggg cctgccaagc aatatcaatt acttttttca 2565601 ccgggtggta atctgacaat ctgagatcaa agacactgcc gttataatgt ttcaaatcta 2565661 ttgtaatatc aatatacatt taggatcacc cttacataga aagagcgccg tcttcttttg 2565721 aatcaggcgc tccttccctt tcatactgtt atccgcggat ttgatttgcg atgtcttggt 2565781 cagtagactc aagtgtattt gctgtttgat caagctgctg attcacatct tgaagcaaat 2565841 ctgacatttt gataaatgaa ggtttgagct gctcgtattg atctgcgaac gcttcgcttg 2565901 aagcaccttc ccacatgctt ttcaaatcag agatcattcg gtttaaacga tcaacctgat 2565961 ttaatacttc ttggctttca acgccgtatt gcttcgccat cgctcttagc tcttcgggtg 2566021 tgacacgaat taatcctgcc atattcctca ttacctcctg tgccatcagc ctaaatatgg 2566081 gctaattcac ttatttttag aacgtcatta ttataaaaac agtttttcgg catagtcaaa 2566141 caaatatgtt ttaattttac aaaatgagtc caatggttta ccccgaatca ctcaaaaatg 2566201 acatatactg taaagtaaat aggtttattt tcttaatctt ctcttcattc tccgaataat 2566261 ccaaaagacc caaataactc tccaactccc aaaaaaaacc tttcagaaaa tttgatgcta 2566321 cagcaccatt tctgaaaggt tcagtttttt ctttccttaa ttagtcttgc ctccgatgac 2566381 tttcttagaa gattaatagg ataagctgtc gtattatatg agacatacac tgtcctgcaa 2566441 aaaggcgatt acaccgccaa atgtatatag aacgtttctc tcatgaaatt gtttttttgc 2566501 ttctgttctt tgttgttgat tttcacaaac aacaacaatc ataataaaag gaaggggatg 2566561 agatgtcaaa gagaaatcaa gcacgaaaag tagggagatt tatgaccatg ccgaatgatc 2566621 cgtttaaata tagttttgac agacttgaag atgtggctga tcatatcagc gacgttctgc 2566681 ggtgcccgat caccatagag gatgttaacc acaagctgct tgcctacagt acacacagcg 2566741 actgcacaga ccctgcccgg acgtctacca ttattggcag aagggtaccg gagaaggtga 2566801 ttaacaagct gtggaaagac gggacaattc ctgctctctt aaaaacggac cagccgatca 2566861 gagtcaagca aatcgatgaa gtcgggctga gcaatcgcgt cgctatttcg atttggaaaa 2566921 acaagcaagt acttggcttc atatgggcgc ttgagatcca aaaaacattg tccgatgaag 2566981 atctgctgac attgcaaatg gcagcaaaag cagtgaaaaa caagcttctc aaacttcaaa 2567041 tcagaaaaac gaaaaatgaa gaacgcagcc aagaattttt ctggaaaatg ctgaccggac 2567101 acatccatca ggaggatgat atggcggatg ggttccataa gcttggaatg gccgctcctt 2567161 cagagttttc cgttatgatc atccgcataa atggcgagct gactgaaaaa atcgaacagc 2567221 agctgcaata tttacaggaa acgacccagc aggtttacgt gctgctggcg accgtagatt 2567281 ccaatgaact tattatatta acctcaccca aaacagatca tccttttcaa gatttaaaac 2567341 agtttgcttt aagtacgcaa aaacagctga aggagcggta taaaatagaa gacgtttcta 2567401 tcgcttttgg cggaatatac aactctattt cttttgtctc ccgctcctat caggaagcat 2567461 tgtccgtctt aaaaacgaag gaacggttcg ctgaagagac caaacatctt ttcagctttt 2567521 ctgagttagg catttatcaa tacttagatg tcttaaatga aaaacggaaa caggcgggcc 2567581 attataatta ctcgctttcc aaactggaac aatatgaccg ggatcaccag tcaaatatgg 2567641 tagagacgct agagcgcttt attgaagcgg acagcaacgt gaataccgct tccaagctgt 2567701 taaatataca cgttaatacg ttgaattacc gactcaagcg gatcagccag atcgctgaaa 2567761 ttgatttgaa aaatgtgaat caaaaattca ccatctattt agatatcaaa cttcggcaca 2567821 tggatttgtg aaatttcaca aatccatgtt tttttatttt cttaatcaaa caaagaattt 2567881 tccaaaatat caagctacac taaaaatatc acatatacag gaggagacag atatgatcat 2567941 aggggttcct aaagagataa aaaacaatga aaaccgtgtc gcattaacac ccgggggcgt 2568001 ttctcagctc atttcaaacg gccaccgggt gctggttgaa acaggcgcgg gccttggaag 2568061 cggatttgaa aatgaagcct atgagtcagc aggagcggaa atcattgctg atccgaagca 2568121 ggtctgggac gccgaaatgg tcatgaaagt aaaagaaccg ctgccggaag aatatgttta 2568181 ttttcgcaaa ggacttgtgc tgtttacgta ccttcattta gcagctgagc ctgagcttgc 2568241 acaggccttg aaggataaag gagtaactgc catcgcatat gaaacggtca gtgaaggccg 2568301 gacattgcct cttctgacgc caatgtcaga ggttgcgggc agaatggcag cgcaaatcgg 2568361 cgctcaattc ttagaaaagc ctaaaggcgg aaaaggcatt ctgcttgccg gggtgcctgg 2568421 cgtttcccgc ggaaaagtaa caattatcgg aggaggcgtt gtcgggacaa acgcggcgaa 2568481 aatggctgtc ggcctcggtg cagatgtgac gatcattgac ttaaacgcag accgcttgcg 2568541 ccagcttgat gacatcttcg gccatcagat taaaacgtta atttctaatc cggtcaatat 2568601 tgctgatgct gtggcggaag cggatctcct catttgcgcg gtattaattc cgggtgctaa 2568661 agctccgact cttgtcactg aggaaatggt aaaacaaatg aaacccggtt cagttattgt 2568721 tgatgtagcg atcgaccaag gcggcatcgt cgaaactgtc gaccatatca caacacatga 2568781 tcagccaaca tatgaaaaac acggggttgt gcattatgct gtagcgaaca tgccaggcgc 2568841 agtccctcgt acatcaacaa tcgccctgac taacgttact gttccatacg cgctgcaaat 2568901 cgcgaacaaa ggggcagtaa aagcgctcgc agacaatacg gcactgagag cgggtttaaa 2568961 caccgcaaac ggacacgtga cctatgaagc tgtagcaaga gatctaggct atgagtatgt 2569021 tcctgccgag aaagctttac aggatgaatc atctgtggcg ggtgcttaat tcacaataag 2569081 cttgcagaaa gatttctgca ggctttttta ttttttaaaa ggaaaaaaga gaccatttca 2569141 cgaattatga ctatgaagtt gatcataaag gaggattcat atggctgttc agcaatatgg 2569201 cgtgttaaaa ggcatagtat tagacatgaa gcgggaaaca gatgatgaca gtcctcattt 2569261 ccaagtcaaa atgctcggtg aagagaatac gtattacagg tgcgccatca atgtgatgtc 2569321 cagttctgag gaatctgaag tattgtattt ggctgacgat cagtttgatt cgggctcaat 2569381 taccatcctt ccgaacatgc cgtatggata tacaaggatc aatgaagcaa accgtgaagt 2569441 ggcactggat tatgtgcggg gcaatttgtt tgacccgcgg gaaatgaagc ctttgcctca 2569501 tgaaatcacg ggacctgata atgatttaaa tgattttatt gaaacctata tgaagaaagc 2569561 acaagatgag aaaacgccgg tttatatatt cggttcaaaa ttcggccctg aacaggctgc 2569621 agataaaata ttcggcttta ccccgactaa cggaatgcac aatatccata tgaatcaagg 2569681 gaatgcaatg gatacccgct ggaaaaaaga caacggctct tggcatgacg ggggtattct 2569741 gattcagttt gcagatcagt gggccgctgt gtttttagcg tttttatccc aatcttggtg 2569801 taccgatgaa aacggaaacc ctgtcagaga ttgtgatcat acccaaacgt ctgcgtaaga 2569861 tagaaaaaga gactgcggca agcagtctct ttttgataag attacacatt ttcaacagtc 2569921 tttaggctgt ttggcctcat atcgctccaa tgcgattgga tatagtccaa acaagcttca 2569981 cgcccttttt gctcatgaac gactgtccag ccgctcggca catctataaa acccggccat 2570041 agggaatatt ggccttcttc attgaccagc accaaatatg tgccatccgc attttcaaaa 2570101 ggatttgcca ttctatttct cctcccttat ttattcaact cttccaattt gacagcgaga 2570161 accttgccga tttgagccag aggttcaggc tgacataaat ctttatgacg gcagtcgatg 2570221 tcgatttgtt caatctgtcc gttaatataa ggcttccacg agtcaggttc aatcgggtca 2570281 aaccattcag gaatgattgt tgatctgaaa aacaaaacat ttccgcggaa ggttttcggc 2570341 ttataggaac ctaaaatgcc gacagaattt acatacgtat tcttcaaatt taaaatgacc 2570401 gtttcatcca ggctcgcaag cgcactgccg tcacggcgaa gaatctcaat cgccgcttca 2570461 aaatctagcg gtttttcccc taagctgtct ggatcatacc cgcctaacgc cagaagggca 2570521 ataagcgctt cctcatcatc cggtgcctct tttataggaa ggaagtggtt cggataggcg 2570581 tccagcatca ccaacaggga tacttcttct ccttgatttt gcagctgggt agccatcgct 2570641 tgaacgacat tcccgcccag ggaccagccc agcagatggt acgggccttt tggctggacc 2570701 gttcggattt gtttaatgta atcggcagcc atgtcatcaa gtgttttcgg aagctcctcg 2570761 cgctgcccga ttccccgtgc ctgcaagccg tagatcggat aatctgttcc tatattggtc 2570821 atcaaaccgg cataacacca gctgagcccc cctgccggat gaacacagaa taaaggaggc 2570881 ttgtctccgc ttgttcggag cggcagcaga acgtcaagag cgctttggct tgatcccatt 2570941 tcaagtcttt cagcgagccc ggctacagta ggtgcttcga acaagttgcc gatgctgagt 2571001 tcaacgccga gcgcttcacg aatgcggctc atgagctgta cagcaagcaa ggaatgtccg 2571061 cctaaatcaa agaaacggtc atcaatgccg acacgcggca agtgaagcac ctccataaag 2571121 aggtcacaga gaatttcttc ctgcggcgtt ctcggtcctc gtcctgtcac tgccgctgcg 2571181 aaatccggag cgggcagcgc tttacgatca agctttccat tcggtgtcag cggcaattct 2571241 ttcatcgtca caaaggcagc aggcaccatg taatccggca gtctctcagc agcatatctg 2571301 cgcagttccg ccgtatcaaa tgtttcttcc gaagggatga cataagctgc taaccgttta 2571361 tctcccggct gatcctcacg aacgatcact gccgcatctt caagctgcgg atgctgaaca 2571421 agcgcggctt caatttctcc caattcaatc cggaatcccc gaattttcac ttgatggtct 2571481 gcacggccga catagtcgag agaaccgtca gcgcggaggc gggccacatc cccagtgcgg 2571541 tacatccggg tgcctggagg accgaacgga tcagctatga agcgttcaga tgttaaacca 2571601 ggccggccta gataacctcg tgctaacccc gctcctgata catacagctc tccggcaaca 2571661 cccggcggga ccggctgcag gcgttcatcc agcacgtata caccaagatc gggaatgccg 2571721 cagccgatca agctgtttgc ccgtaaagct gccatgcttc ggtctaattc gatatagctc 2571781 acatgcaccg tcgtttctgt aataccatac atattgataa gctgcggtct attttcaggg 2571841 tggcggttgt accaatcctc taaacggctg agttcaagcg cttctccgcc aaaaatgaca 2571901 tagcgcagac tgagtgcctg tccgagatcc ggctgttccc gttccgcctg cataaactga 2571961 tagaaagcag acggtgtctg gttcagaaca gtcaccccct ctttgacaag caggcgcaga 2572021 aacgcttctg gcgatctgct gacgtggtga ggcacgatta caagacgtcc gccatgcagc 2572081 agaggacccc agatctccca caccgaaaaa tcaaacgcat aggaatggaa catggtccag 2572141 atatcacctg agctgaaacg gaaccagtgc tcggtcgctg caaataaacg tgttacattt 2572201 tggtgaggaa tcatcacacc ttttggaaca cctgttgagc cggatgtata aatgacatat 2572261 gccgtattca aaggggaaag cggctgagtc ctatccttat tttttggatt acctgcaggg 2572321 tacgtgttta gtttctctgc cagctcggga tcatccagca cgattttcgg cacgttttca 2572381 actggcggaa tgtgatttgc agctttagtg ttcgtcatga taaacgcagg ctgtgcatct 2572441 tttagcataa aagcaattcg atcagccgga taatccggat caagagggag ataagctgcc 2572501 ccggccttta gcaccgccaa taggccgaca gccatttcca acgatcgggg cagtgccaat 2572561 gccacaaatt gctccggccc gacaccttca ctaatcatca ttcgggcaag ccggtttgct 2572621 ctttcattca gctctgcata gctcagttcc tgattttcat atacaacggc aatggcatca 2572681 ggacgtaaag cagcctgctt ctcaaattgc tctggcaaac atgcgtgcgg aatcttttca 2572741 gatacacttt gccaatcagt caccatgctg ctgtgttcct ctggcgcaag aatatccaga 2572801 tttccgattt gctcgtcagg atcagactcg gcagcctcca acaggcgcat caatcggtca 2572861 gcaagagcct gagcagtttc ccgtttgaaa agatcagtgc tgtattcaag cagtccttcc 2572921 attccgtttg gtgtcccgtc agcaaggcga tcttcactaa tttccagcgt caaatcaaac 2572981 ttggcagaac cgacactgtt gattcgcagg ctgctctcca tatcaggaag atgcagttca 2573041 gcgtccggtg tgttttggaa cgcaagcatg atttggaata aaggatgcgt cgcacgcgaa 2573101 cgagccggat tgagcacctc tacaagtctc tcaaacggca gatcctgatt gtcataggcg 2573161 gccagattca cttcccgtac tctgtctaga agctcacgaa agcttgggtc accggacgta 2573221 tcagttctga gcaccaatgt attaatgaac agccctacaa gatcgcccag cgcatcatca 2573281 ttccgtcccg cgatcggact gccgatcgga atgtcggtgc ccgccccgag ccttgtcaat 2573341 aaagcggcga gaccggattg aagcaccata aacaggctca ccctatttgc gcgagccagc 2573401 tcctgcaatc gcttgtgaaa ctcgggctca atacgaaaat gaatcgtatc tccatcatga 2573461 ctcggctcag ccggacgtga ataatcggtt ggcagttcaa gctgatcagg caggtttttc 2573521 aaggtttctt tccagaaagc aagctgtccg gcaatcaagc tatttggatc atcctcgttt 2573581 ccaagcagtt cttgctgcca aagcgcatag tctgcatact gcacagcaag aggcgcccat 2573641 tcgggagatc gtccgtggca gcgagccgca taagctgtcc caaggtctct ggtcagcggt 2573701 gttaaggacc agccgtcccc gacaatatga tggacgagaa gaagcagcac gtactcgtca 2573761 ggaccgatca caaaaagctc ggcacgaaaa gcaggttcag ctgcaagatc aaagctgtag 2573821 cgtacagctt cggcaagccg atcagaaagc tccttctcag caatttcagt aacatgtaac 2573881 tcgggacagg ctcgatcggc atctaaaata tgctgatagg atgtcccctg tgattcaggg 2573941 aagatcgtcc gaagactttc atgacggcag acgaggtcat aaagtgccgc tttcagcaat 2574001 ccttgatcca actcacctga caaacggaca gcaaccggaa tattataagt aggactcggt 2574061 ccttccagac aatgcaggaa ccatagccgg cgctgggcaa atgagagcgg gatcttttca 2574121 ggccgctcag ctctctgcaa agcgggacat gcactctgcg ccaaatcaag atgggcagcg 2574181 agtccggcta ctgtcggttc gtcaaagagc ttggcgatac caagttcggc tcccattacc 2574241 tcgcgaatgc ggctcatcag acgggctgca agaagagaat ggcccccaag ctcgaagaaa 2574301 ctgtcatcga taccgacgcg tgccaaaccg agaacctctg caaacaagtc acacaatatc 2574361 tcttcctgag gagtccgcgg ggcccgatca ctgacagatg tgctgaagtc tggtgccggc 2574421 agtgctttcc ggtcaagctt gccattaggt gttaacggca gctcgtccat ctccacaaac 2574481 gccgacggta ccatataatc aggaagacta gcccccatat aacgacgaag ctctgcagta 2574541 tcaatagcag catcagcgac tacataagcc gccaatcgtt tgtctcccgg ctgatcttcc 2574601 cgtacgacaa ccgcggcctg ttcaatgtgc gggtgattgg caagcacggc atcaatttct 2574661 ccaagttcaa ttcggaatcc gcgaattttg atttgatgat ccgcccgccc gatataatcc 2574721 aaagacccat cggcgcgcca gcgggcctgg tctccggtcc gatacatccg agttcccggc 2574781 ggtccgtatg gatctgcaac gaagcgctcc gccgttaaat caggacgatg gaaataacct 2574841 ctggccaagc cggttcctgc aatataaagc tctccgacaa cgcccggcgg caccggctgc 2574901 aatccattat caagcacata cacctgcgtg ttccaaatcg gtttcccaat cggaggaacg 2574961 cccttcagcc cttcttcaag aaaagctgcg gcagaccaaa tcgttgtttc agtgggaccg 2575021 tataagttcg tgactgaaca atgaaggtct tgaagttcct gcaaaagacc gctcggcagc 2575081 gcctcgcctc ctacaagcac tctaagcccc cgaagtttct caggttcact cgttaccaaa 2575141 gcgtgccaca gtgtcggtgt cgcctgcata atgttaatat cgaaattttc aatcatttga 2575201 gctaatgcct gcggctcacg gatcgtttct ttctttgcga tcacgatttg cgctccgcta 2575261 atcagcggaa gatataactc caatgctgaa atatcaaaag cgacagtcgt cacagccaac 2575321 agcctgtctt cttctcctag agaaaatgcc tcctgcatag acagcagaaa attgcttaag 2575381 cttttctgtg tcacaacgac tcccttcggt cttcctgttg atcctgaggt atagatgata 2575441 tacgcaggat ggtcaagcga aaccgataca tcctgatttt ccggcgaata gcgttttata 2575501 atctcctgtg taacagcctg atcaagcaca agctcaggta cagccaggtc atcaggcaga 2575561 ctggctgcta tttcctcagt cgttatgatg catgaaggtt tcgcatcctc cagcatgtaa 2575621 gaaatgcggt cggctggaaa ctccggatca agggggagat acgccgcacc agtcttgagc 2575681 acaccaagca ttgaagccac catctcaggg gaacgcggca gcgccaaagc gacaaattgc 2575741 tccggaccaa tccctttttc gatcaacaga cgcgcgaggc ggtttgcctc ttcattgagc 2575801 tttcgatagt tgacttgaat gtcatcacac atgagagcga tacgttctgg cgtaagaact 2575861 gcctgctttt cgaacatgtc ctgaaggctg accagcttct cggattttgc cgtctcattc 2575921 catttagaaa tgactttttc tttctcctct ggcaacagaa gctccatttg cccaatcagc 2575981 atgtcctctc cggcagaagc cgtttgcagc agctgcaaaa tacgctgctg atgaagctta 2576041 atatcagact cactgtatac ctcgggattc gcatcaacat caattcgcag cccgctgccg 2576101 tctgttctgt catatacatt gattgataga tcatcaacag gaccggctga aagattatgc 2576161 gttgtgcccc ggacgccggc aaagtcgaga ccgtaatcaa acggcataag attgatttga 2576221 gggccaaata atctatgatt ttctcctatc aatttcagat cgcgcctaag ctcttcatgg 2576281 cgatacttat gatgtcgccg aatactgcgg atttcccggg aaatttgctg aatcagttca 2576341 gaaaagctca tcgaagagct taccgtcagc cggagcggga gaaggttcat caccatagcc 2576401 ggtacattca gtgacgcgga ccctatccga cccatcatgg gcaggccgag cacaacatcc 2576461 tcagagccgg tcatacggtg cacataaaca gctgacaccg caatcatgac ttcatgccag 2576521 cttcctgaga aatagcgcgc cgcttctttt aacgcgttta catcagacgg aggcagatat 2576581 gccgtatgac gaagaaaact gttagatgtt cttggcgccc gatcagccaa gctcacaact 2576641 tcaggtgcat ctgcaaaacg gtccagccag aattgacgat ccttctcata ctgctctgat 2576701 ccgcgataat ctgtatcctc ctccaaaatg gcctggagag acccaaagga acggctttta 2576761 gctgtttgtc cttttataag ggcagtatat gtacttgcca cacgctgggc tatcagggaa 2576821 aaaccgaagc cgtcgatcgc tatatggtga atgcgctgat accaaaagaa acgatcaggc 2576881 ccggcaataa acagagcttc attgaacaaa ggggcatacc ctaaatcaac cggctttgct 2576941 aaatcagctt tcatccagtt taatgctgtt ttttccggat caggctcaga gctgacgtca 2577001 atgacgtgca gctgtacatc cggagacggg tttatcatct gccaaggccc gtccatattt 2577061 tcaccgaagc ggacatgcag cgattccgct tccttgatca cgtgccgcaa agcttcttca 2577121 aaaagagcaa tattgactgg tccattgatt tctatatatt ccgctgtatt gtagattgga 2577181 ttgtccggat caagctgctg agcaaaccat atgccagttt gcgccccggt caaagaatat 2577241 tgaagatctt ttgtatcagg catccgtttg tttaccctcc ttttataaat aatccgcgtt 2577301 tggcagcact tgctggctgc gagttgtgag caatttctgc cattcttcga tcgttgggcg 2577361 ttcagccaat tccacgaaag tcacctctgc cccttcacgg cgccattgtt ccaccaatgt 2577421 catgatcctt accgaatcaa gaccacgatc gagcaaatcc tcttgatctg tgatgtcttc 2577481 cggtgtttct tgtagaagct cagcaatttg tttacggata ttctcacatg taaacacgtt 2577541 ctttttgcca gtgtttgctg acgttttttg aacgtctgcc ggcgcattct gcagctgatc 2577601 aagaagactg tcagtcatca cggtaaacgc acagcgtcca gccgcatatt ccagcgccat 2577661 ttgatgtttt tctaatgaaa aatcagcaac tgcatctccc acaaaaaagg ctttaatatc 2577721 ctccataaat gcttcacatg ctgtaacaag acagccgata tgggcgtaaa ttcctgtaat 2577781 gatcagctga tcgcgtccct ctttgcgcat catttcaagc agattcgttc tcttaaacgc 2577841 gctgtatctc cattttgtca gcacaagatc atcatcctct ggtgccagct cggttataat 2577901 tttctcctca taaggaccgc tgtttaatcc cgggccccaa aagtctgtca gcagcgcacg 2577961 gtcatccgga ttttggcttc ccggctgtgc ggtatagaca acaggaatcc caagctgaac 2578021 acattgattc ttcagctttc gtatattcgc tgaaagctct gttaccggag acgctcccgc 2578081 tgtgaaagca tcaacaaaat agttttgcat atcgtgtatt aacaagacag cccgattcgg 2578141 atcaggcacc catgatactt tgttttgcgg catatcagat gctgtcggca tttgatacgg 2578201 ctgaatggca ggtatagcca tatgaacact tcctctcaaa ttgttgtttt attttttaaa 2578261 tcctgcaaga agcttctcgg aaatggcttc acggagcgct tttttgctga cttttcctac 2578321 tcctgtctgc gggaaggatt cgacaaattc aactcgatca gggattttat atgccgccag 2578381 tccgcgctct ctcaaaaatg ctttaagctc tgcggctttt ggggcttcat cccggggaat 2578441 aatgaacaca caagatcttt cgccaagaaa ttgatcaggc atggagacca ttgccgcatc 2578501 atggacagcc ggatgcgcca gcagatgatt ttctacctct tcagccgcaa ccttttctcc 2578561 tccacggtta atttgatcct tcgcccggcc ttcaacgaca atatagccgt ctcgtgtcag 2578621 cctgacgata tcacccgtac ggtaaaaacc gtcctcagta aatgaagcgg cgttatgctc 2578681 ttctgcctta tagtaacctc gaattgtata cggcccccgc gtcagcagat ggcctgtttc 2578741 accaggtttt acgtcgcgat catgatcatc ccaaacacgc atttcatcat atggagacat 2578801 cggttttcct tgggtgttga caatgatctc ctcaggatca tccaatctcg tataattgac 2578861 gagaccctct gccattccga acacctgctg cagcgtgcag ccgaaaacag cttttaccct 2578921 gcgcgcggct tcagcactaa acttggcacc gccgacctgc agcacttgaa ggctggataa 2578981 atcatcacgg cgtgaggatg ccgcatccat ccataccatc gcaagaggcg gaacaagagc 2579041 ggttatcgtg accttttccc gttcaattaa aggaaatgcg tcatctggac ttggagaagg 2579101 agataatacc actcttcctc cagcgtataa tacgccgaga acgccgggtg agctcagcgg 2579161 ataattgtgt gccatcggca gcgcggccaa gtacaccgtg ctgtggtcga gccagcagac 2579221 ctccacactc cgcttcaggc tgtatatgta gtcatcgtgg gtcctcggaa tcagtttcga 2579281 tagcccggtg ctcccgccag aaagctggag gaacgccaca tccgatgatt tgacttcagg 2579341 cagttttaca ggttctgcat gcaaatcctc cagcggtaaa aattcctctg cctcacctgc 2579401 gacaatgatg tttttcaaag tcggcagctt gctttgaacc tgtctggcaa gcgaacggta 2579461 gtcaaaaccg gaataagcgt cgggaatgat atatgcagcc gcttcagcaa actcgcaaaa 2579521 atatgtaatt tcactgcttc gatgagaagg cagtgcgaag actggaagcg cccccagacg 2579581 gaaaagcgcg aaaatgactt caaaaaactc tttgatattt ggcaactgca ccacaacacg 2579641 atccatctgt tgaatgccga gcttttgaaa tccggcagcc aggcgatcag cccttgtgtc 2579701 aagctctcga tagctccaat gggtgtttcc gcatgtaatg gcaatgcgat caccatattt 2579761 ggctgcccgg tcccttaaca aatctccaaa cgtctcaccg gcccagcagc cgttctttcg 2579821 ataggtctca gctaactcat caggccaagg cgtaaatcct ttcagcatgt tgtatccctc 2579881 cagcaattca ttctgttcat atgtgatcca cgcccattgc ccgcagcatt gtccgaaact 2579941 ttgcggacgt ctcctgaagc tcgtcctcag gctttgaacc ggccacaaca ccagctccag 2580001 catacaggcg gagtgagcgt tcttctgctt ctgcacaacg gatggtcacg atccattctc 2580061 cgtcaccggc atcgtcacac catccgacca tgccggtaaa gaaaccgcgg tcaaatggtt 2580121 caatgctgag aatcgcttct cttgcaagat cagtcggtgt tccgcagacg gctggcgtcg 2580181 ggtggagcgc cgccgccaat tcaagtgcgg ttacagacgg gtcggaaagc tctcccttaa 2580241 tcacgctgga caggtgccac atcgtttccg ttttgatcag tgaaggcttc tccggaacct 2580301 ccagcgtccg gcagaaaggt ctcagcgctg ccgcaaccgc gtcagcgaca accgcgtgct 2580361 catgaagatc ctttgcggaa gaaagcaatt cagctgcccg gcgctggtct tcaacaggat 2580421 cattactgcg cggtcttgag ccggctaatg ggttggaaac gacctgtgtt cccatccttg 2580481 aaacgagaag ctccggactt gctccgagca atgttctgcg gggagacgtt tcctcctgac 2580541 tggacacgtc tgcggcaaac gtgtagccat gcgagttatg ctgagccaga tggcgaagca 2580601 attcatccgt ctgaatcggt tcaggcgatg tcaaatgcag cgatctggac aggacgattt 2580661 tgctgagtgt tccatcggca atgcgtgcca gcccttgttc aacaccattt ttataatcct 2580721 caggttcagg aacaggcttt atgtggtatg tatgcccagc ctgctgttcc ttttcctcat 2580781 gatcaaattg aagcggtcct gaccagcgca cttcttcagg tacaacgagc cgcgctgctt 2580841 ttacttgatc aaaaggaacg gccccgacaa caagcggccg gctttgccct gattgttttg 2580901 cctgacgtaa cgcctctgca attcggccag aaagggtttc catttggttt tgcccgtctg 2580961 cctccggtac aatttcacat atgcctttcg ctaacagtac acgatgagga gacgctaaga 2581021 aaaaggcgcc cggctgatat tcatgaagca aatgctccgc ttttgtttct gttataacgt 2581081 tttgatccaa cattctcatg aacctccttt aaattcagtt acacgcctaa ggtcgcgccg 2581141 ccatctacgc ataaattatg catcgtaata tgccctgcct ggccagaaac caaaaagagc 2581201 accgcatccg caatatccga aggcttggct agttttttga gcgggatccc tgttttaaat 2581261 gtctcaagtg atccttttat gacttgctcc gctccattct cgtcggccca taatgaccac 2581321 tgcatgtctg tttccgttga tccgggagat acaatgttgc agcgaatatt gtattctgca 2581381 agctcaaggc caaggcattt cgtaaacatc acagccgcag cctttgaaga cgcatatgcc 2581441 gccatagatg ttcttggtac accggcagca ttcgatccga ctgttacaat cgaacccgat 2581501 cttcggtcca tcatatattt gctgactgaa cgcgaggcgt taaatacgcc agtcgaattc 2581561 actgagaacg tcgcctccca ttcctcatcg ctaagcgaat ggatcagtcc cgggcgaagg 2581621 acacccgcta cattcactaa aatatcaatc ggccccattt cacgttcgat gcgcgccgtg 2581681 atctcgtcaa tcgccgcgct gtctctcaca tccgcaggaa aagcttctgc atggcggcct 2581741 tctgctttga ggctgctcac aaccttttcc agcttttcag gattataatc aactgccgca 2581801 atatgtgcgc cttgactggc aagcgtccgc gcaacagctt cgcctattcc ttgggcagcc 2581861 cctgttataa aagcaatttt tccctctata ccctttgcat tcatatcatc aattcctttc 2581921 ttcgctctaa atgccaaaca gacatccagc gaaaaagact gctgcgcctt gaaaaacgca 2581981 atctattgat aatgattatc attatcaatt ataaaaataa tcatatccaa atgtcatgtg 2582041 acagtcaaat ataatttcag tgacaaatat ttttttaaag gcaaggctga gtatgtctca 2582101 gcccattgat agatgcggtc cgtcagggtg aagcgcaaaa cgcagcgccc tgctgaccaa 2582161 aacaggaaga actgaaatat gtccttctcc tgaaaactcg caaaattctg cccgtatacc 2582221 ttgttcagat aaaacggcca gccgctcata aagctccctt gcattatcat tcatccggct 2582281 tttatgatgc tgctctaatt ctcctgcggc aagcaggata ttgataggct gattgttttt 2582341 cttggtgaga gagacgaaat ggtccgtttt cttgagaata aacggtttat tccaatgaat 2582401 ggacggactt cccgcgatat acgtttgaaa cgcatcgggc tttgttagca gcacctgcag 2582461 cacgaaaagc cctccgagcg aatggccaaa gattgtttgt ctttttttat caatctggta 2582521 atctcgttct atctccggtt ttaaatcctc ttcaataaat ctgaaaaagc cctccgctcc 2582581 gccatgctcc ggccattctc tgccgtcggg cctttccggc agcttcgatt gggctgttgg 2582641 cattgtaaaa tcccggtggc gtgctgagga gaacggctcc gctgtctcat agccaatgcc 2582701 gacgatcact gcagggatca ccccggtttt ttcgggtcgg cgtccctgta ttcgaacggc 2582761 ttccgtcatc gttccgaaga cagaattggc atccagcaga taaatcacag gataaccagc 2582821 gggtggcggc ggcgtactag gtttcgagat aaaaatgtga taggtacggt tttcattgcg 2582881 tgaagacatc atacgcactt ccgtaccagg aatcgtaaat gcgtttgatg tcccgccatt 2582941 tgtccggtct gttgtttgtt ctttcatgca gtacgacatt cctctcctta aactaaaccg 2583001 caatgtatga taatgatttt cactatcaac tagacacctc aaataatagg ttttcttcca 2583061 aagaaagtca actttttccc gaataaaaaa ggcaccttga tcaaataagg tacctgcaga 2583121 ctatcaatat ggaagtaaaa acctaataaa gatgcgtatt gtcctatttg aaatagaacc 2583181 ttaatcccat gtaaaccttt gattttgcca agggtcgcct ctcatgtgat agccattccg 2583241 ctcccaaaag ccagggtgat tttctttcgt aaattggatg ccgcgcagcc acttggcgct 2583301 tttccaaaaa tacagatgcg gaaatacacc ccgcagcgga aagccgtgtt caggggttaa 2583361 aggttcgcca ttatgcgcat aagccagaag ggaagtttcc gctaagaaat catcaagcgg 2583421 cagattggtc gtccagccct cttcagcatg taaaatgacg tagcccgctt cttcttttac 2583481 acccgctttt tccgctatat cacaagcccg cacgccttgc cacacattat caagccttga 2583541 ccatcccgtg acgcaatgaa tgtcgttttt cgattcatac cgtggaaagg ctttgacatc 2583601 ttcaaagctt agcagcatcg gatggtcaac caaaccgtat acttgaagat tccatttcgt 2583661 catatcttcg taatatggga catctccggt atgaagcaca ggaaatgaag tggtgacgtt 2583721 ttgatttggc ggcactcttc cagattgatc ggactgtctt gtttttccga aatacatatg 2583781 ggcctccttt ttgttaacct aatttaaaat catgttgaca atctttttgt tctttattac 2583841 tctatgattg tgtatgtcaa cctaaggggg aacaacgatg aaacaacgta aacttcgtgc 2583901 gggagatatg gcgctgattg gcatgttcgc cgcacttatg gctgtcgggg ccaacattac 2583961 atcagtagca ccctttttac aagtagccgg cattccgctt tcgatgcagc cgtttttctg 2584021 tctcttggca gctttgcttc ttggcagcaa acgggcagcg attgccatga ttgtatatgc 2584081 acttgtggga ttggccggag cgcctgtgtt tgctcaattt tcagcaggct tcgcaccgtt 2584141 tgcagggaaa agcggcgggt ttattatctc atacattccg gcagcatttg cagcgggatg 2584201 gtttttagaa cgaaacattc agccaagtaa aattcgattt ctcattgctt cacttatcgg 2584261 aacggcgatc atgtatctca tcggcactac ctatatgtat cttgcactga agctgtggat 2584321 tcatacgcca gtgagctacg gcacggcttg gggctttatg atttggttta tggtaaaaga 2584381 tacagcgctg gctgtgatac tgtcgtttat cgcaccagca atctaccgct ctattcataa 2584441 agcaaccggc tttaacagaa atcacatatc atctacgtaa aaaccgttct attggacggt 2584501 ttttttatca taacgagaaa aggctcccca gtaaagggga gcctttttcc tataaaacaa 2584561 gcgctgcaat ccagccaaag atgacaagcg gaatattata aaatataaat gtcggcacac 2584621 aagtatccca aatgtggtga tgctggccgt ccgcactcaa acctgaagtc ggcccaagcg 2584681 tactgtcact ggcaggtgaa ccggcatcgc caagcgcagc agcagccccg ataatcgcaa 2584741 tcgttgccat cgggctgaat ccaagctgca tgcatagagg cacgaaaatg gttgtgataa 2584801 caggaatggt cgcaaaagaa gatccgatcc ccattgtaat taataagccg acaatgagca 2584861 tcagcaatgc gcccaaggac tgactgtgtc cgataaaacc agctgacgtt ttgaccagtg 2584921 actcgacatc tccggttttc gtcaatacgt ttgaaaatcc ggctgcaaca agcatgacaa 2584981 agccgataaa ggccattaaa accattccat cagtaatcag tgagtccgct tcatcacgct 2585041 tcatcacacc gctgacaaac agaacaatca gaccagcgag cgcccccata atcattcctt 2585101 ctactcccaa agtctgagat aagtaaagct ggacgccgag tgacacaaca atggctagaa 2585161 ccgcgatacc aatacttttt ctcgtatatg gcgatgcttc tgcacctgaa atgtcttttg 2585221 tttcatattg tttcggttta cggtatacga tcactgataa aataaggccg acaaccatac 2585281 ctgcaactgg aataatcagt gcgtacggaa tatcagcaag cggaacgttt aacccggcat 2585341 ccgccatatt gtccttcagc atgccttgga agatttggcc gaaaccgacc ggaagcaaaa 2585401 tataaggagc cgttaagcca aatgtaatta cacacgcgat cagacggcgg tccatttcaa 2585461 gttcattaaa gattttcaaa agcggcggaa tcagcaccgg gataaacgcg atgtgaaccg 2585521 gaacgacgtt ttgcgaaaaa caagatacaa ttaaaataat cagcacaatc agcaccttag 2585581 acagtgcttt ttttcgagaa tcttctttat ttccgattaa tttaacggag gcttccacca 2585641 ttgcgtccgg aagacccgtt ttcgtcaaag cggcggcaaa cgcgccaagc atggcatagc 2585701 taactgcaac ggtggcattt ccgccgagac cgtctgtgaa agctttaacc gtttcgccaa 2585761 gaccgagccc gcctgttaac ccgccggcca aggcgcctat aattaatgcg ataacaatat 2585821 tgacacgcag caggcttaat acaagcataa gcaggactgc gatgacgact gcattcatga 2585881 tgatacccct ccaaaaatcc tttagtttgc taatgtagta gataaataaa gtacgaacgt 2585941 atcgtatcat aaccgatcca ctttagtcaa ctaaagattt cggaagaaaa aatccctgcc 2586001 gcatcataca gcagggattt ttcattactc gtttttatct tcttccaatg taaatcgctc 2586061 cgcaagtgta gccagtgttc ttgccataac gccagtagcc ccggccggtc cgaagcaggt 2586121 tgctttattg gcagtcgctg tgcctgcaat atcaaggtga acccaaggtg ttgactcagc 2586181 gaattcacca agaaacgttc ctgccataat cgcatgtccc tcgcgtcccg gtgaattgct 2586241 gagatccgcc atttggctgc ttttcacgcg ttttttatcc ttctctgtta tcggcagctg 2586301 ccagatcgcc tcgccgcact cttgtgcagc atcagctacc tgctggtaaa agctttgatc 2586361 atttgtcatt gcaccggttg tttctgttcc taatgccaca acgacgccgc cggtaagcgt 2586421 agctacatcg acaagaactg atgcgccatg ctgtttcgcg tatgtaatgc catctgcaag 2586481 cactagcctt ccttcagcat ccgtattaag gatttctatt gtttttccgc ttaaagatac 2586541 gatcacgtca tccggcttca tggccccgcc ggagatcata ttatcggttg atggaataac 2586601 gcacagcacg ttttgttcag gacgaagctc tccgatcgtt tccatagccc cgagaaccgc 2586661 agctgctcct cccatatctg atttcatgcc aacaattcca gatttcgttt taatggagta 2586721 gccgcctgtg tcaaaggtaa ttcctttccc gactagtccg acgacgtctt cccattcctt 2586781 tttgccctga tatttcaaca caatcatttt cggcggttcg gtggagcctt ggtttaccgc 2586841 aagtattccg cccataccga gctcttccat ctctgatttc tccaatatct cacactcaaa 2586901 atcatatttc gccgcaagct cttcagcata cgaagcgagg tcagtcgctg tcagcatgtt 2586961 tcccggcata ttcacaagcg ttctagccga atttgtccct tgtccgtatg cctggccgac 2587021 gcgaagccct gcctgcactt cctgtgtatc ttcatctgtt acaacataca cggcttcaat 2587081 ttgtttgtca ggctcatttg atttatgctt ataatcctgc acctcatagg aagcaagcag 2587141 gcagctctca gctaaagcat gagcggcatc ggctggaggc acgtcttccg aaataaacgt 2587201 atcaagcaga acagcagttt cttgttttcg atctttatga atggcttgaa aaacatgagc 2587261 aaaacgttcc ttcgcctgtt caaacgaata atttgcttct ctccccaggc caacgaaata 2587321 aatccgtttc atacccgcag aagatggagg gaatactttt gatacttgat tcggtttcgc 2587381 agagacatca ccctctttta aaagctgtgt cagatggcct tcgagcattt catcaatttc 2587441 caacgctttt cctgtcagct ggcttttttg aaaaagcccg acaacaaggg tttctgtatg 2587501 ctctgattgt tgaaccgcat aaaacatgag gcttacactc ctaacgtaat gggtatttgt 2587561 aatgaacaat ggtataatag gaaaaacatt ctttccacta tacttatttt aacaaacaac 2587621 agtctaagac ttgctttttt cttttgaaac acgaaggatt tttcaaatag aaaggatgtc 2587681 gccgatggaa cttttaacga attttccttt attatcaagc ctggccgcaa ttatttttgc 2587741 tcaggtcatc aaagtgccca tacagtttat cgtgtccaga aaactggact ggtcgctggt 2587801 cacaagcaca ggcggcatgc ctagctctca ctccgcagcg gtcactgcgc tttctacagg 2587861 cgtagccttg gagcatggat tagactcctc actctttgcg gtttccgcca ttttcgccgt 2587921 cataaccatg tttgacgcaa ctggcgtcag acgtcacgcc ggtgagcagg caacagtcat 2587981 taataagctt gttattgatt ttaaccgttt cgtaaatgaa gcgaaggact tccctaaggc 2588041 tgcagagaaa gaaaagcaaa aaaagctgaa agagcttctc ggacatcagc cgatcgaagt 2588101 ctttttcgga ggattaacag gtattttact gacattggta ctcgcttact ttttcatgta 2588161 aaaaaaacgc tcctgctttc gctggagcgt tttattcttt caccgtttta tattgatttc 2588221 tgaacacttg caaagatttt gtttcattga gcttctcaag ctcatcctcg gtaatctttc 2588281 ccgttccctt tttaatcaca tatacatcaa gggttttttt gccccattca ttgtatacat 2588341 ctttgactgt ctcaaagtac agatcaaggc ggtttccctt aatagctgat cctgtgtcgg 2588401 ccacaactcc gagaccgtag ttcggaatga ataaaattgt tccgatcggg aaaacggacg 2588461 ggtcagcagc aaccgtggaa tataaatccc gtttcacttt cacacctgaa tatgtaagcc 2588521 cgtataatgg atcaccggga tttttgcccg tcgactcagc tcctgctgtg tagcctgttg 2588581 ctgttactct ttggactgga tattcatccc aatcaaatgc ctcttctaac ggttttgttt 2588641 tatcctcagc cgcggacgtg gtttgtgttt gtttctgctg caatgctttt aatctcagtc 2588701 ctgcatgctt caagtgcttt tcctgatgtt cctgcaccca ttttgacaag tccttcgctt 2588761 caattcctga cactgataaa aatgtcgtgc caaatgcaag cagaaataaa caggtcatca 2588821 gcaaacgtct gatcatattc aacatcattc acctctcctc cgaatcattg ttcccaagtg 2588881 gagagagcat tattcaaaat ggtgaatgag ctgaacgcat aaaaaaagct ttctttagaa 2588941 gaaagcggca tttaaaacat ttgatatcct ctttttctaa gcatgttgat cgctataccg 2589001 gacacgatgg cgccggccaa accgctgact aaaatcagca catcagcagc cgctaatgat 2589061 aagacacgat gaaacaggct ggcaaaggat tctcccggcg actggacata gctgatcagc 2589121 ttttctttgc tgataatgaa aaggcataca attggataaa tcacagccat aatccaagac 2589181 attctcagca gcatgtttaa taagaaaccg attccaaaaa acaagacaaa aaacaaaaca 2589241 attgagatga ttacgactgg cagactaatc aacctattcc acccccctgc gttgttttta 2589301 gtgtaacgcg ggggctgaaa taaagtcaac ggctggaaaa agaatgactg tcttttcctg 2589361 tcccctggca agacggacaa gtctctgaac cgccgagaat caattgaaaa tatcctttcc 2589421 ctgaacaaaa tgggcatgca tgtgaagcgg ttgtcgttgc agttttcatc taatcatcac 2589481 cctttttctt aattttctga taatatacca tatcaagctg tcaacaataa agtcagatca 2589541 tgtgacaaat cttttgatgt aagcggaaac atacttgttt tcctctcgtt ctctttttat 2589601 tttggcgttt tttaataaag aaaacccgct tccgcgggtt tttagaaaaa cttgaacttg 2589661 ccttttttca atgtcagtcc gagtccgcca atcataaaca gtgagcggtt atcaatgact 2589721 tttttcataa acgaagcggg cgtgcctttc agctttctgc cataaacaac cccaaccgcg 2589781 ttatgctcgc caagagaagc cactgttccc ttaatgtccg gcttgaattc ctcaagctct 2589841 ccgcctttaa taagcctgcc aaggttttta gcgaccgtta tgccctgctg cattgcaatt 2589901 tgcgcagtcg gcggatacgg gcgctctgta tcttcattca taaacagcga gctgtcgccg 2589961 agaataaaga cattgtcatg tcccggggcg cggagatcag ggttgacttt gactcggccg 2590021 cgcatattct caaaaccggc ttcctccaca atcggatggc cgcggacacc tgccgcccat 2590081 acaacggttt gcgatttgat ctgctctggt tcttcatctt ttttgccgac tctgactcct 2590141 tctggtgtac attcttgtac agccgttccg atcttgaact caactccgtt ttcctcaaga 2590201 taatgtacgg cgtaatcaac aagttccgga tcaaagcccg gcaaaacggt cggcgctgct 2590261 tccacacaaa tgatgcggac aaggcttctg tcaacgtcat attccttaca gagctccggc 2590321 acgcgagcag ccagttcgcc aagaaattca attcccgtaa atccggcacc gccaacaacg 2590381 atcgttaacc tgtccggccg tttttccgct tccgtattgt aagtcgcaaa ctgcagctca 2590441 atatgttccc gcagcaggcg cgacgtgttg atgttggcaa tcggaaacgc atattctttt 2590501 aagcctttaa tgccgaacgt ttcaggcacg gcgccgagcc cgatgactaa ataatcgtac 2590561 tgcaattctc cattcgcaag cacaactttt ttctcatcaa ttttgattgc ctttacggta 2590621 tcctgtacaa aattcacccg tgactggttg attacatctt ttatctgata acggcagcgg 2590681 tcatgatgga gcgtacccgc gctcgcttca tgcatccatg tcgtttcata atgataattg 2590741 tgtttattta caagcgtaat gtcagcatca ttcggcccga catacttcgt cagccttgtc 2590801 accgtcatca atccgccata tcctgcacct aaaatcacga ttttgggctt attcaatgcc 2590861 atcacatcca ccttctcttt ttttgctttt gttagaccca taataaaatc atcatttgtg 2590921 ttagcttcag cttattggcg ggattttatg aaatatattg aaaagttttt tgtgaagtcc 2590981 ttacccgtag cactattatc atgtttatcc ggctggccca agaaacattc agaaaaagat 2591041 catttcattt ggttattatc gtagcggcct gcggaaatat tttcaagaac ggatgggcac 2591101 gttagatcct tacgattttt tctgctgact cgtcaatttg aacggcaata tggtataatt 2591161 aataacaatt ttcatttagg aggcaatttt cgtatgcgag aggatacaaa ggtttatgat 2591221 attacaatta taggcggggg accggtcggc ttattcaccg ctttttacgg cgggatgaga 2591281 caggcaagcg tcaaaattat cgaaagcctg cctcagctcg gcggacagct tagcgcccta 2591341 taccctgaga agtatatata tgatgtagcg ggattcccga aaatccgcgc gcaagagctt 2591401 atcaataacc taaaagagca aatggcgaaa ttcgaccaaa ccatttgtct ggagcaagcg 2591461 gttgaatctg ttgagaaaca agcggacggc gtgtttaagc ttgtaacaaa tgaagaaacc 2591521 cactactcta aaacggtcat cataactgca ggaaacggcg cattcaaacc gagaaagctg 2591581 gaacttgaaa atgccgagca gtatgaaggc aaaaacctcc attacttcgt tgatgatctg 2591641 caaaaattcg ccggcagacg cgttgcgatc cttggcggtg gagattccgc ggttgactgg 2591701 gcgcttatgc ttgagccaat cgcaaaagaa gtatcgatca ttcaccgccg cgacaagttc 2591761 cgagcgcacg agcacagtgt ggaaaacctt catgcgtcga aggttaatgt cctgacacca 2591821 ttcgtccctg cggagctgat cggcgaagac aaaatcgaac agctagtgct tgaagaagtg 2591881 aaaggcgacc gcaaagagat tttagaaatt gatgacttaa tcgtcaacta cggtttcgtt 2591941 tcatctcttg gaccgatcaa aaactggggc ctggacatcg agaaaaattc cattgtcgtg 2592001 aaatcaacaa tggaaacaaa tatcgaaggc ttctttgcag caggtgacat ttgtacatac 2592061 gaaggaaaag tcaacctgat tgccagcggc ttcggcgagg caccgacagc agtgaacaac 2592121 gccaaggctt acatggaccc gaaagcccgc gtacagcctc ttcactcaac aagtcttttt 2592181 gaaaataaat aataaaaaaa ggagcttgtg tctgcgacac agctcctttt ttatttgaag 2592241 atatttatat aattcaatgc agttcctaca accagcgcaa tcacaagggc tgcgactacc 2592301 cagatcattg ccataataat gcggtcctga atcttttggg acttcggtgt tttttcttcg 2592361 ttttgggcca tcttattcgc tcctttccca tgtccatgcc ataaagaaag cctggtgctg 2592421 aacgaccaag ctttgctgaa cgtatatcat tcgcgttttg atccgctctc taagaccatt 2592481 cgttaaaact atgataccta aactcaccct gcatgacaag cttcggcact tgcaccacac 2592541 ctgccagcaa atcataatgt ttgacatcct aaataaaaca gagtacatta tataaggcga 2592601 acatttcata tattatactt ttaaatattc gtttttagga gtgaaaacca tggaaaacgt 2592661 atttgattac gaagatattc agctaattcc tgcaaaatgc attgtgaata gccgttcaga 2592721 atgtgataca tccgtacgtt taggcggaca tacatttaaa ttgcccgtcg tccctgccaa 2592781 tatgcagacg attatagatg aaaaactagc gatttcatta gccgaaaatg gctactttta 2592841 tgtgatgcac cgatttgagc ctgagacacg aattgatttt attaaagata tgaacgcacg 2592901 cgggttattc tcttctatca gcgtgggcgt caaagatgag gagtatgaat ttgtccgcca 2592961 gctggcagaa gaaaatctga ctcctgaata cgtgacaatt gacattgctc acgggcactc 2593021 aaatgctgtc attgaaatga tccagcacct taaaaaacat ttgccggaca gctttgttat 2593081 tgctggcaat gtcggaacgc cggaagcggt cagagagctt gaaaatgcgg gagcggatgc 2593141 cactaaagtc ggcatcggac cgggaaaagt atgtattacg aaaatcaaaa caggcttcgg 2593201 cacaggcggc tggcaattag cagcgctgcg ctggtgtgcc aaggctgcca gcaaaccgat 2593261 tatcgcggat ggcggcatcc gcacccatgg cgacatcgca aaatcaatcc gattcggcgc 2593321 aacgatggtc atgatcggtt cactatttgc cggacacgaa gaatcgccag gccaaacgat 2593381 cgaaaaagac ggaaagcttt acaaggagta cttcggctca gcctctgaat tccaaaaagg 2593441 cgaaaagaaa aatgtcgaag gcaaaaaaat gcacgtggcg cataaaggct caatcaagga 2593501 tacactgatt gaaatggagc aggatcttca atcttctatt tcttatgcag gcggaacaaa 2593561 gcttaacgcc atccgcaatg tggattatgt gattgtgaag aattccattt ttaatgggga 2593621 taaatattaa tcataaaaaa acgccaagtc agcggttctc cgcttgagtt ggcgttttct 2593681 gctacttctt cagcaaagta agcttatatt tgctttttga gtttatcttc catcagttct 2593741 gccatttgtt ttgcatttgg attttcttca ttttgcaact gttcaatgac gttcatataa 2593801 tccgtttcat ttcggttctg gcttaattta tatgccgctt gaatgtcttc caccttaatc 2593861 ttaaatccaa caataccttt caattcactt tctaagagtt ttggagaaag cttatcccat 2593921 aacacaggat tgtcacgatg tttttcgtat ttctccaaca tgattgttaa ttcttctgct 2593981 aattcatctt tctctaacat acttgctttt ccatacatgt ggacagcctg ataattccac 2594041 gtcggaacat tttcgcgcga ataccaggaa gaagaaatat aagcgtgcgg tccctgaaac 2594101 atcacaagca catcttcaca ggcttcaaac gttctccact gaggatttcc ataagcgaaa 2594161 tgccccgtaa tatagtaatg atcgtctttt ttattgaatc ctaacggcaa atgtgtggca 2594221 attggttttc cttgttctgt tgtgacaacc gtaccaaagg agttttcttg tacaaaattc 2594281 caaatttctt cagcatttgt gactttaaaa tattttggaa tatacatcat catccaccct 2594341 tcgaaaaata ttatatgagt gttttagcca tgattaaatc cgtttgttct tcatcaccca 2594401 tataaaatga gtgggcgccg gtctgaacaa accccatttt cttataaaag gcaatggcat 2594461 tttcattttt ttcccacaca cctagccaaa tgttcttttt attacgttcc agcgcaattt 2594521 ctatcgcttt attcagcaga tgtttgccaa gcccatgttt ttgaaagctg ttctttatat 2594581 aaattctctc gatttcaagt gattcagcac ccatttcttc agactgagca tcatcgatat 2594641 tgacctttac atatccagcg atttcatgat caaagtaaat aaaaaagaat tgcgaagaca 2594701 tattagataa ctctttttcc agctgctcag tgttaaatgc gctttctaaa taggctttca 2594761 tattttcagg tgagttctgt tctttaaaag tgtcattgaa tgtttcaata ctcaattgtt 2594821 gaagtgtttg taaatcttcc cggctgcatt ttttcatttt tacactcatt gttcggattc 2594881 agccccttta tttaaaattc aattgtcttg tgtccctttt atatatttaa acacggaaca 2594941 catactgacc ttgttaccat tccaaaaatc ttcttcatca ccaactccct atcgtgattt 2595001 tgttgtaaat gcaataaaat atactccgca ttaaatatat cgtaactttg ctgtatttac 2595061 aacaaaaatc aaacaacaaa gcagcgtttc tcttgccgaa gttcccggaa ctctctgcat 2595121 catttcccca taataaaaac gcctccctta acgatgattt atcgctaaga aaagcgtcag 2595181 taatagttgc tatccgtttt tagtgcttag cactcttcag gcttgcctgc attcgttgct 2595241 gttctgaacg aagaaccgca gccgcatgaa gcgatggcgt ttggattgtc gatggtgaag 2595301 ccgccgccga gcatggattg tttataatca atcacggtgc cgttcatgat gtcaaggctt 2595361 tctttgtcaa ctagaacagt gatgccgtgc tgatcaaaca cactgtctga ttcactcttt 2595421 tcatgctcaa agcccatgcc gtaagaaagt ccgctgcagc cgccgccttt gacgcctaca 2595481 cgcagaaacg cgttttcttc ttcatgctct ttcatcatat cttttatatg caaagctgct 2595541 gcttctgtaa ttgttaccgg gttgctcatc attatgaacc tccttttaaa aaccggttgc 2595601 tgtcttttat tataaacatg atcgttccaa ttctcaaaca aggtgtttta caagaaatag 2595661 acaccctcac aaacggtttc agccggccct gtcatcatta catggccgtt atctttccag 2595721 tttatcacca aatccccgcc tgctaaatgc accgtgatgt cttgatttcg ctttgatacg 2595781 ccgtttaata cagatgcgac tgccgctgca catgctcctg tcccgcatgc ctgagtaatc 2595841 cctgatcccc gttcccagac gcggaaatgc aattcttgtt cattcacggt ttcaacgaat 2595901 tccacattga tgccttccgg aaatctcgga tctttctcaa tcaccggccc cagtgtcgtt 2595961 aagggtgcct gttcaatgtc tgcgatcgga aaaacgatat gcggatttcc cattgaaacg 2596021 gcagtgcctg ttagttctac ttcaccaaat gccatcgttt cattgattgt gtgctcttcc 2596081 ccgccgtcaa gcataggaag ctcggatttt gtcaagcgcg gttcgcccat atcgacagtg 2596141 accacattca cttttccgtt ttcgacttga acctccgctt tcacaagccc ggagagagtt 2596201 tcaatcagaa aagatgtttc ctcaaccagc ttatgctcat atgcgtattt tgcgacgcag 2596261 cgcaggccgt tgccgcagtt tttcccttca gacccgtcat tattaaaaat ccgcatttta 2596321 acaggcgctt ggtctgatgg gcatatcagg atcattccgt cggatccgat ccctgtataa 2596381 acagaagaaa cctgaattgc aatctctgac agtttttctt ctggaagctg ttcttcaaat 2596441 tgattcacat aaatataact gtttcccagg ccgtgcattt tggtaaatcg aaatgagttc 2596501 ataggtgcct ccaacttttt ttctttttct tagtataaaa gctattataa gcggacacaa 2596561 tacaattatc ccccgttttt catacataaa agctccttgc actgacgcaa ggagctttta 2596621 tcgtttatat aaacatgccg gcaatggctg cgctgagcag attggctaat gttcctgcaa 2596681 gaacagcctt caggccgaga cgtgcgatat ctgaacggcg gctgggcgct aaaccgccaa 2596741 gcgtaccaag cataatcgca attgatgaaa aattggcgaa tccgcataac gcgaaactga 2596801 taatggtagc agttttctta gaaaactcgc cgatgtgcga accgaagtta gaataagcga 2596861 caaactcatt cagcaccaat ttctggccga tatagcttcc cgcctgcaat gcttcatgcc 2596921 aaggcacgcc aatcaaaaag gcgataggag aaaacacata gccgagaatg gattctaatg 2596981 ttacgccttt taaaccgaac aagccgaaag ccccgccgag aataccgttt actacagcga 2597041 ttaacgcaac aaacgcaagc agcatcgccc caacatttaa cgcaatttgc agtcctgttg 2597101 acgctccctt tgcagctgcg tcaatgacat tggctgcgcc ttcgccttca tccattttga 2597161 aatcgctttt tacggtttgc gttttttccg tttcgggtat aatcaattta ccaaagacta 2597221 gtccagctgg agcagccata aagctggccg ccagcaagta ctcaatcgga ataccgagaa 2597281 gcgcgtaccc aaacaaggta gatcccgcaa ctgccgatag accgctcgtc ataatcgtaa 2597341 acaactcaga gcgcgtcagc ccggcaatca ggggtttgat cactaacgga gattctgatt 2597401 gtcctacaaa aatattggca gcagccgcca gagattccgt tttgcttgtt ccaaggagct 2597461 tcgacaatcc gccgccaatg acacggaaaa cgagctgcat gattttcaaa tgatataaaa 2597521 ctgcaatcag tgctgagaag aaaatgataa cgggcagtac acttaatgca aatgccggac 2597581 tgtctccgac ctttagaagc ggtccaaaaa taaaactgat gccttcattc gcatagtcaa 2597641 tcagaagctg tacacggctt gaaaaccata aaaaaacagc gcgtcccgct tcccatttca 2597701 acacgatgta tccaaacgcc acctgtgtgc ataaaccaac gatgacggtt cttatcttaa 2597761 tattgctttt cttttctgaa aataaaaacg cgatagcaat gatcgcaact gcgcccagca 2597821 gcccccacag aacattcatg aatactcgta cacctcttaa attttattta aaaaaatatc 2597881 ttttatacga taacaataat attttttgat gtctacacat ttttttagtt cttttgtacg 2597941 gcaaaataaa aaagggcctg tccaggccct tttctttaaa acattggatt ttcttcaata 2598001 aaggtatata tattctcaac aagctcagca ggcgtttcac ccatgacgac ttctccgttt 2598061 accagagcga aaagcgattc catacatgtc ccgcagtagc ttaagcagcc atattcaagg 2598121 acatcaaggt tgggatcctt ctccaaaatc gcccgggctt cctgagagcc gtgagccaga 2598181 ttgctgacac aaaattcaat cattggattc atgcggtttc acctcacata tgtccattat 2598241 cgcgaatttt tcactattcg tcaaagacaa cggatgattc aaaatttatt atcgtaacat 2598301 attatttctc aaataacgtt ttactaattt gtgttttcag gctaaattgt aggttatttt 2598361 gaaactatta ttgtgatttt agatcaaatt cgatataatt ctagatgtta ttttacatag 2598421 ttcgtatttt cttcaatgta tctatcatac tcttcggatt aaaggggaat tcaaatgaaa 2598481 aaattggtct tgatcggcgg aggttacggg aacatgcgcg ttcttcatcg cttattgcca 2598541 aaccagctgc ctgatgatgt ttcaatcacg ttaattgaca gaaatcctta tcactgcttg 2598601 aaaacagaat attatgccct tgccgcaggc acaatttctg accatcatat cagagtgtca 2598661 ttcccagagc accctcgcct ggatgtccaa tacggtgata tcacatcaat tgatattgta 2598721 caaaaacaag tgctgttcca agatcgtgaa ccgatttctt acgatgacgc cataatcggg 2598781 ctcggctgtg aggataaata tcacaacgtg ccgggagcgc ctgaattcac ctacagtatt 2598841 caaaccatcg atcagtcccg cgaaacctac caaaagctga ataatctgag cgctaatgcc 2598901 accgtcgcca ttgtcggagc gggcttaagc ggcgttgagc ttgcaagtga attgagagaa 2598961 agccgtgatg acctgaacat tattttgttc gaccgcggta atctcatttt atcaagcttt 2599021 cccgagcgtt taagcaaata tgtgcaaaaa tggttcgaag agcacggtgt ccgcattatt 2599081 aacagggcaa atatcacaaa agtagaagaa ggcgttgtgt ataaccacga tgatccgatt 2599141 tctgcagacg ccatcgtgtg gacagccggc atccagccaa acaaagtcgt cagagactta 2599201 gatgtggaga aggacgcaca agggcgtatt gtattaacgc ctcatcataa tcttccaggt 2599261 gatgaacatc tgtacgttgt cggcgattgc gccagtcttc ctcatgcacc gagcgcccag 2599321 ctggcagagg ctcaagcaga gcagattgtc caaatcttgc aaaaacgctg gaatggagaa 2599381 gccctgcctg aatcaatgcc gcagtttaag ctgaaaggcg tcctcggttc actcggaaaa 2599441 aaagccggct tcgggcttgt tgctgaccgt ccgctgatcg gccgtgttcc gcgtatgctg 2599501 aaatccggct tgctgtggat gtataaacac cataacggtt aatgatagag aagaaccgct 2599561 gatcaagtca gcggttttct gtatacccat gcttctccat ttcctcataa acgtctttta 2599621 attttggatt gccttcaccg acaattttgt cttctacaag cacaagcgga taaaaatact 2599681 cgtcatttct gattttttcc gcaagctctt tcgcatgttc attgtcaggc ggctcatgaa 2599741 tatcgatgta ctgcatctca aaaggctgat ttggatattt tcttttcagc gcagcctcaa 2599801 gccactcgta tgtatccttg gctgtcggca tatttacaca gctcgcacaa acgttttctg 2599861 ccccgtacac gcttagcatg actggtttca tcacttgtag acgccccctt ctcctatgta 2599921 agtcctttct tttaagtata cagagcctaa gggcgttttt atagaaaaaa accgtttttg 2599981 tgttgaagtc tgaatgtgct ataataggga aagcaacttt gcaaaccaaa caatagattt 2600041 ttattgttac actgaatata atggttttat gacgacgaaa ggagcgaatg tcatgactga 2600101 agttgaaatg aaagaacagg tgcaggaagt actggacaaa cttcgtccgt ttttacttcg 2600161 tgacggcggt gactgtgagc ttgtagacgt agatgaaggt atcgttaagc ttcgtcttct 2600221 aggcgcatgc ggcagctgcc caagttcaac aattacgttg aaagccggaa ttgagcgcgc 2600281 tcttcttgaa gaagtgccgg gtgtcgttga agtagaacaa gtcttttaat aaagcagcca 2600341 ggctgatatt tgatcagcct ggctttttta ttagagatgt tgatcaaacc atgagctgat 2600401 ataattcagg cgcttgatcc gctgtcttgg gtgtccggtg cgtgataaat tgtgcgatgc 2600461 attcggaaaa cggacaagct tggtttcctt gcccattttt ttcagagcga taaacagctg 2600521 ctccgcctgc tcgatcgggc atcggtcatc ccgctcgcca tgcagtatca aaagcggtgt 2600581 ctccacgttt gctgcgtatt ttaaaggaga ccggtcccag agcttttctg tgtcctcaaa 2600641 catgtcatgc tcaagctgcc agtctgtaaa gaaatagccg atatcactga cgccgtgaaa 2600701 gctgatccaa tttgatatcg agcgctgggt aacggcagct ttaaagcggt tcgtctgccc 2600761 gacgatccag ttggtcataa aacctccgta gcttccgccc gtgacaccga gccgcttagg 2600821 atcaatatgc ggatctcgtt tgatagcctc atccacagcc tgcatcacat cgtcataatc 2600881 ctttccccca taatctcctc tgaccgcatt cacaaattcc tgcccgtagc cgtggcttcc 2600941 tctcggattg atataaacga ccgcgtatcc tttcgccgcc agcacctgaa actcatgaaa 2601001 atatgtatgt ccgtacatca tatgcggacc gccgtgtatg ttaagaataa gtggatatgt 2601061 tgtctcacct tccatttgtg caggcctcat cagccagccg ttcaccatca cgccgtcttc 2601121 tgtagcatat tgaatctctt caggtattga tatcgtatgc tccctgacaa acttgtcatt 2601181 cgcgccagtc agctgtttct cttcctgtcc aagcgggata ctgtaaagct cactcggtct 2601241 gtccggcttt gtcacactgg caataaagtg ctgttcatca ggtgaaagag aaaagctatt 2601301 gatgtactct ttttccagac gaatcggata cacaaggcct tcaatcgaaa tataatagat 2601361 gcccgtactg ccttgatctg tgccgatgac ataaaaccct tggctgtcct ttgtccaaat 2601421 cgggcgctgt tcagcaccac cgatcaatga atctccaatc agcgcatccg ctaaatgaac 2601481 gtccagcatc tcagtaagac atgtgaggcg gccttgttcg atatcataga gccacgcctt 2601541 tgagagcgta gcattcttat attccttttc atttccaagc aaagcaagat accttccgtc 2601601 tggtgaaaat gagcttgatc cgaatgagcc gcgatgaggt gtaacctgct taagatctcc 2601661 agactccagt gacattatgt aaacatcatg cggcttgctg gcatcatctg tttcagttaa 2601721 attagctgag aaaacaagcc atttgccgtc aggagaaaaa gcaggatcac catgatcagc 2601781 tttgtgactt gtcagctctt tcatctcacc cgactttacg ctgacaagca caagctgggc 2601841 atacgcacct ctcgtcagcc ctttgccgtc ccgtttgtag gagaggcctt gcacttcaac 2601901 aggttcatag ctgtcctgct ctgttttttc tcggtcatca atgctttccc cctctcccaa 2601961 actgacagtg accagaatcg attcaccgtc cggggaccat agcggctttg acacgccata 2602021 tgggatatca gtcagttttc ttgcttctcc gccttcagtg ctcatgatat aaagctgtgc 2602081 cgcatcgcct tctcgatcag aaataaaggc aagcgtgcgc ccgtccggag accatcttgg 2602141 gtcggtgctt cgcttttctc catgtgtcca aggaacagat cctcccgttt tcgtttcata 2602201 gatccatata tttgatgtat acgaatcttt ctcttgattt acttgtgatt ttacatatgc 2602261 ggcacgggta ccgtctgggg cgtattgagg atcggtcaca gagacaatcg ctgtgatgtc 2602321 gtctgcggtt atcagctttt tcatattcat ctcctccttt ttacatgtat ttcgtttttc 2602381 taaataaaaa ctcctttatc tccagcaaaa aaaagcgccc tccgctgacg ctgaggaacg 2602441 cttggcatga tctatacact ttttacttga tataaaggat ttcgctctat tatacttccc 2602501 tctttcggaa cggtcaaagc gtctacttca caatgaggga aatgaagcgc gagctgttct 2602561 tttagctctt ctccctttcc tttttcggtc atgacgagaa tcgttgggcc tgctccgctg 2602621 agagccgttc catatgcgcc cttcatctcg gcgacgtgct ctacttttga cagctcaggc 2602681 acaagcatcg cccggtacgg ctgatggaac atatccttct tcatgatttt cccgacaagc 2602741 ggccaatcct tggacatgat cgcagcaatg aggatattgc tgacagcact tgcttttacg 2602801 gcatcggcat atggaaactc cttcggaagc acgtctctcg cgtctcttgt cagcacttca 2602861 taaaaaggaa tgacaacgac tacgtcaatg tcagcattcg ggacgcggat catttgggtc 2602921 tcgtcatcct catgcaggcc gatcacaagt ccgccgacga gagaagcgcc agcattgtcc 2602981 gggtgtcctt cttctagact cgctaaatgc agcttgtccg cttcagacag ctttaagccg 2603041 cataattcat cagccagttc aatggccgct acaatcgctg cggcgctgct gccaaggccg 2603101 cgtgcaagcg ggatgtcgct ccacaccttc acatggacag gaggcatttc ttttccgtac 2603161 aaatctgcgg tccgtttagc cacttggtag atcaggttat ctgtacccgc cggaattccg 2603221 gcgactgttt ctgtttcagc ctcaaaagac catttgtcgc tttcaaagac ggtcagcttc 2603281 aaatatctgc tgagcgccat tccgactgaa tcaaagccgg ggcctaggtt agctgtgctt 2603341 ccgggaacag tgacagagaa cagcatgtcg gcttcgttca tacacgggcc gctcctttta 2603401 catattcaag gatgctgtct tcatcagtcg gcaatgtgac aggcttgatt tctgaaatgt 2603461 cgaccgctgt gttcggatct ttcagtccgt ttcctgttaa cacagctacg accttgctgc 2603521 ctttcggaat ttctccggat ttcacctgtt tcagcactcc tgcgatagac gcgcaagaac 2603581 ctggttctgc aaacacgcct tctacacggg cgatcagctg atatgcgtga aggatttcat 2603641 catcagtgac ttcgtcaatt ttcccattgg attcctcggc tgcctttaca gctttgtccc 2603701 agcttgccgg gtttccgata cgaatggctg tcgctattgt ttccggattt tcaatcactt 2603761 cattgcgcac gattgccgcc gcaccctcag cttcaaagcc gcgcattttc ggaaggcctg 2603821 tgccgttttt ctcatgatat tccttgaagc ccttccagta cgcagtgatg tttccagcat 2603881 ttccgaccgg gatcgctaaa acatcaggcg cttcccccag ctgttcgcac acttcgaagg 2603941 cagcagtttt ttggccttca atgcggtaag ggttgactga gttgacaagg gcaatcggtg 2604001 atttctcaca gatggaacgg acaattttaa gcgcatcgtc aaagtttccg tcaattgcga 2604061 taatctcggc tccgtacatg acagcttgag cgagttttcc aaatgcaatt tttccgttcg 2604121 ggatgatgac aatgcatttc atgttagcac gggctgcata tgctgccgca gcagcggaag 2604181 tgttacctgt tgacgcgcac ataatcgtgt cattgccttc ttcttttgcc tttgccacag 2604241 ccataaccat tccgcgatct ttaaatgatc ccgtaggatt gacgccttcc gttttgacat 2604301 gaagctcaat tccgagctgc tcagacagct tcggcaggtg aataagaggt gtgtttcctt 2604361 catgtaaagt tagcgccggt gtttgatctg ttacaggtaa aaattcttta tattgatgga 2604421 taagtccttt ccacattagc tccaaccgtt cccttctaca cgatatgtgc ttttgacttc 2604481 ttgaacgact tccaaatcat ttaggttttg caggatatca ctgaaatcag cttctgatgt 2604541 atgatgtgtg acaattacga tttcagctaa ctcatcatgg cctttaattg gcagctgaag 2604601 gattttttca aagctcacgc cccgctctga gaacacagat gtaattttcg agaatgaacc 2604661 aacctcatct tttacatgaa ttcttaaaaa ctgctgtgca taaatgtcag acggcgattt 2604721 catgtttttc tcatattgcg gtccgacaaa gctgttgccg gttacaccta ggcgcatatt 2604781 tttcatgaca gcgacgaggt cagaaacaac ggatgtcgct gtcggcatgc ttccggctcc 2604841 cggcccgtag aacatcgtct caccgacagc ctcgccgtat acataaacag cgttaaactc 2604901 attatgaaca gcagaaagcg gatgatggtc aggaagcagt gtcggctgta cgctgacctc 2604961 gattttgctg ccgtcacgct gagcaatccc gatcagcttc attgtatagc cgaggcgttt 2605021 gctgaagctg atgtcctcgt ctgtaatttg ggagatcccc tttactttga cgtcttccag 2605081 atccacgttc atcgagaagc cgaggcgcgc caatatcgcc attttccgtg cggcgtcaag 2605141 cccttccacg tcagaagtcg gatcagcttc ggcaaaaccg agatcctgcg cttccttgag 2605201 cacttcctcg tatgggcttt tctctttgat cattttggtt aagataaagt ttgttgtgcc 2605261 gttcacaatt cccatcattt ttgtaattcg atctgatgag aggccttcct ctaacgtgcg 2605321 cagaatcgga atcccgccgg caacactggc ttcaaagtag atatcgcatc cattttcctt 2605381 cgcttcggca agcagctcgg agccgtacac agccattaag tccttgtttg ctgtgacaac 2605441 atgctttttc gatctcagcg cgtcgaccaa atattgtttt gtctgttcaa cgccgccgat 2605501 cacctcgatg acgacatcaa catctggatc atcaatgaca tcatacactt ctgtcgtgag 2605561 cacttccttc ggcaaatcta cttctctctt tttctctaaa tcttttacaa gcactttttt 2605621 tatcgtaacc ggacagccga cctgatgcat aagcttatcc tgatggtctt gaataatttt 2605681 aacgacaccg cttccgacgg tacctaaacc taaaagccct acacgaatcg ctttcaaaaa 2605741 aactccacct ttcttttgat tgtcctcttg gaaaagacaa ttgttaactc aacacagaca 2605801 tataagttac aaacattata taagcccgct cctgttttga caagacatca ttaggctgaa 2605861 ttttgcgaat gtaaacgctt aacgcattga tatgacaaga ttctttattt tctaattatt 2605921 tttgtcagat tttctcctca ccttgagctg cctttgccga gccagctgac gcgtggaaca 2605981 aacagcttct gcgcccgcat attcatgaat tcctgcgctg tattgagaaa ttgttcataa 2606041 cgcccacagt cattaagaat gaagtcaagc tgttcttcaa aataatgctt ttctgattct 2606101 gatgacatgt aatagctttc tacgatttca aaataatgaa gcgggaaaag cagacggctg 2606161 tataaaaggc gtttcgaaaa tgaagacagc ggtgtgactt gctcgtattc ctgtaaaaag 2606221 agaaagccct gctgattaaa atcttgtctg tgatgcaaaa acgtatgcct catatattca 2606281 gccaaatcac gggaagcgtg gtcaaacacc caatccgccg gaatcctgat caatgattcc 2606341 ggtgaccatg tatgcctttc catccgctga tggcatatcg ttcctgaatc agcggcttgg 2606401 ggcttgtcat ccagctcagt gtccactaaa tattgtatcg cgttttctga cagtcctaaa 2606461 taatatggaa atgattcgat cattttttta tcgaatggct catgcggagg ggtctgaacc 2606521 tttctctgcc aaaatgcttc cagctgatca attcgttttc cccacagatc cttccactgg 2606581 ccgattcttc cggccgcctt cacctcatat ggatatcctc ggccttttcg gtgaaattcc 2606641 gcaagctccg ctccaatgga gaacgccctg tttgaataag ggggggccgc cttcagcaga 2606701 gcgtacgttt ttccctcatg ttcaaatgtc agttcacctt cttttgtaaa gataaaaacc 2606761 gaaacgtatg ggtcactttg ttcttgtaaa tactgactca tgtaataaag ctccgccagc 2606821 tctgtttctg agaattggga aacggggaca atcagaaagt atgaattagg cgtctgaaag 2606881 cattgatatg tgtgctggta catggaaagc tgcctgatgt gaatgccgta tttttctttt 2606941 attgtacctt tcaccatgat cacctgcctg ttgaattagg gctcatcaca tcgtagtcat 2607001 acacagccgg aattatgaat acatatttta atccgaagaa ggcgcaagaa aaagtcgtaa 2607061 acttctcaag cattttgtat aaactagtaa aaaagattgg gtgaagctga tgtcagaaaa 2607121 cgaacaattc agtcagatgg aagctaaagc aagagcacgg atgaaggagc gcggcgttga 2607181 ggtatcagac attgccgagc ttgtcttttt tctgcagaaa aaatatcatc cggatttaac 2607241 cattgatgaa tgcacgctga acgtcaatcg tgttctcgca aaacgcgagg tgcaaaacgc 2607301 gattttaacg ggcattgaat tggatgttct tgctgagcag aaaaaattgt ctgaaccgct 2607361 gcaaacgatg ctggaaatag atgaaagcct atatggagta gatgaagttc tggcattttc 2607421 cattgtgaac atttacggat cgatcgggtt tacgaactac ggttacatcg acaaagaaaa 2607481 acccggaatc cttaaacgat tgaatgataa atcaaccggt gaatgccata cctttttaga 2607541 tgacatcgtc ggagcgattt ccgccgcggc ttcaagcaga cttgctcacc gcgcgcggca 2607601 tacagaataa gggcaccctt ttagggcgcc cttttttcaa atgtatggaa tccattcagt 2607661 cagagagtca atggcgtgag tcggtttttc catatcgtct gtcatatgtt ctcttttcgt 2607721 tacgcctgtg tgaacgagca gcgtatccat acccgcgtta atgccggcca taatatcagt 2607781 ggcgtagttg tcgccgacca tgagtgtttc agacacatct gtgccgagaa cgcgcatcgc 2607841 ctgctccata ataattgatt ccggcttgcc gataaataca ggctgtacac ctgtagatac 2607901 ggttaacacc gatgtcagtg agccgtttcc cggcaggagc cctctttcag tcggaatcgc 2607961 aatatctccg ttagtggaaa taaagcgggc gccatttctg attgccaggc agccaacagc 2608021 aaatttttcg tatgtaatgg aacggtcgat gccaacaacg acaaaatccg cgttttctcc 2608081 gccaaatgtc aggccgtttt cttcaatcgc ctggcggatt ccttcctccc caatcacata 2608141 cacagacgcg tcttttttct gctgtgcaat gtgctgggca gttgccatgc tggtcgtgaa 2608201 gacctgctct tctgttgccg gaatatcaaa agacacgagc ttgtccgcta cctgcttcgg 2608261 tgtgcgcgaa gagttgtttg tcacgaaaag ataaggaacg ccgcgatctt tcagcgttct 2608321 gacaaattca cacgcctcct cgattttttc cgtgccattg tacatcgttc cgtctaaatc 2608381 aattaaatac cctttatatg ttttcatatc caacactcct gtggctttcc agttgttatt 2608441 taaacgcgga aacaggtcct agctctgttt ccaaatagct tctgatccgt ttcgggaagt 2608501 cctgaagagc tgtttgatgc gccttgatca gcctgtaaag ctcgccgctg tcagcgagca 2608561 gatactgttg aaccaacgtt ttgcggtagg cgatcaattt tttgagctca tcaccctctt 2608621 tttccgtgac aactttctca tcaacaagta tatccataat gtcgtcatag ctgcccgggt 2608681 cccgcataat aaagccgtca atcatgtcat tgcctgtatc caaaatgcat tcgattaaca 2608741 gatggcctat acgctgaagt gccaattccc cgatttcaga ctgccagtct gtttgtgagt 2608801 caaatagcgc cagctggtgc tcgaagaacc ctagtgtttt ttcgattttg cttctgtcaa 2608861 caaaatacat gacagcatcc cctttgtgta tatttatttt ctgatccgtt tcaagacaaa 2608921 atacgcacag ccgaaattgc agtattcgta aatatattca tctaatgtgc tgattttcgt 2608981 ttcgaaggtt gccttttgat tctggtcgtc aaagaagccc ttgagcctta actgaccgta 2609041 tccccagtct cccacaatat aatcgtattt atttaatata tcggagtagc gggctttaaa 2609101 agcctcttcg ttgaagccgt ctttgaaatt gtgcaccaat tcaaattcgg cattttgaat 2609161 aagaatcatg atctcacctc ttttttcact cattcctatc ataattcatt gccccgtccc 2609221 catcaattgc taaagaataa atcatgcgat ttggctaccc tacacatgag gagggattga 2609281 taaatgaaac gaaccgctgt cagcctctgc ctgctgaccg gactattatc cgggtgcgga 2609341 ggcgcaggat tggataatgc ccaaaatgtc cggaatcaga cgcagaatca aaccaaaccc 2609401 attcatgtgt cggaccgcaa cgaggctttt aacaggcata atgagaacga acaatttggc 2609461 tatgtccgct atcaaaaaga acaatttgac ggagaacagc agaaaacgcc ggtgatgaac 2609521 cgggaagaaa ccgctcacat gatatcaagt ttaacggttc agctccccca tattcaagat 2609581 gctgcgacat tggtgactga ccgagaagcg cttgtcgtat acaaaaccga ttctaaaaac 2609641 cgggagctga ccgccgatca ggtgaaaaaa acagcggctt ctgtgatacc gcgatactat 2609701 cacgtgtata tttccgataa tccaaaccat atgcaatccg tcgaaaatta cagcaatctc 2609761 ggctctggtt caagggatat tagagagatc atgtcgggga cgattcaaga aatgaaaacc 2609821 tccccgcaag gaagccctgt ctcagagaat gaaaatgcca atggagaaac gcgtcaggac 2609881 atgaaaatcg ataggaatga caaaaacgcc agatgatctg gcgttttggc attatgcttg 2609941 tgcttgacgc tttttagatg cttcgtttac ttgttcatcc gcatggtaag aggaacggac 2610001 aagcggaccg gcttcacaat ggctgaagcc tttttgcatc gcgatttctt ttaattctgc 2610061 aaattcatca ggatggtagt atttttggac tttcaagtgt ttcttcgtcg gctgcagata 2610121 ttggccgatt gccataatat ccacgttgtt cgccaagagg tcgtccatta cttcaataat 2610181 ctcttctttt gtttcgccga gtccgatcat gatacttgat tttgtcggaa tgtcaggctg 2610241 catttccttc gcacggcgca aaaattccaa tgaacggtcg tacgtcgcac gcgcgcggac 2610301 tcttggcgtc aggcggcgaa ccgtttcgat attgtgattc aggatgtctg ggcgtgtatc 2610361 catcaaggtt tttaggttat cgtagtttcc gcccatatca gacggcagca cctcaattgt 2610421 tgtgaacggg ctttttctgc ggatcgcacg gacagtttcc gcgaaaatgc ctgccccgcc 2610481 atctttctga tcgtcacgcg caacagccgt aatgaccgcg tgtttcaaat tcataagcgc 2610541 gactgaatcc gctacgcgtt ccggctcttg cagatcaagc tcagttggaa ggcctgtttt 2610601 gacagcacag aaacggcatg ctcttgtaca aacagaacct aaaatcataa atgtcgctgt 2610661 acgtctgacc gcccagcatt catgaatatt cggacacttt gcttcttcgc atacggtatg 2610721 caggttgttt tcccgcatga gttttttgag ccctgtatag ttttcatttg tatttaattt 2610781 aattttaagc cattcgggct ttctgaggtg ttcgtctttc tttgccaatt cccatcatct 2610841 ccaatatcca atatactcaa tttctgacac gaaacattct gaaaacgaga aaggtgcagg 2610901 ttttagttct gcaacaaaaa taatgttttt ctaactaaag aaagtctttt ctttagacac 2610961 tttaacatag gaaaaatttc tcgacaaggg aagatgatta ctgacatttt taagccgggt 2611021 tgccgcaaac tatgtgtatt caatatgaaa ggagattatt ttgtgaaagt tttgttatcc 2611081 gctcttcttc tccttttgtt tgcatttgag ccttctgcgt ctggaaaaaa actttcagat 2611141 ccagtgctgt cgaaacggat ggaattatat cataaaatcg aagctgtgac gcagatccct 2611201 tggtatgcgc tcgccgctgt tgatcaatac gaagaaaacg tgcggagcaa ccggaaagat 2611261 ctgcctgaaa aggcgggaat catcagcatc tatatacccg atgatatctg gagcgggcct 2611321 gaaaacccga atccgaaaga cgatgcgccg ttaagcatta aagtgtttga cggaatcgga 2611381 atggatggcg atggagacgg gaaagccgag gtcagcaacg atgaagatat cttgtatacg 2611441 ttcagccaat acttactgtc gtatggcaca gatgaagaca acatccggat cgggctttgg 2611501 aattattacc ggcgtgatca gacagtgggg attatatctg aattcatgaa gctgtttaaa 2611561 gcctacggcc atattgatct gggcgagcat gcattcccgc ttccgatcag aaccgattac 2611621 agctaccgaa gcacgtgggg agatgcccgc ggcttcggtg gaaggcggat tcatgaaggt 2611681 acggatatct ttgcccatta cggccttcct gtcaaatcca catgttacgg cgtagttgaa 2611741 atgaagggct ggaaccgctt cggaggatgg agaatcggca tcagggacat taacaatacg 2611801 tatcattatt ttgcccatct caatgggttt gccaaaggga ttaaaacagg acaaatcgtt 2611861 gagcctggcc aagtgatcgg atcagtcggc agctccggat acggcccgcc gggaaccgcc 2611921 gggaagttcc cgccgcatct gcactatggc atgtacaaag ataacggaag aaccgaatgg 2611981 tcatttgatc catacccgca tttgagggcg tgggagcgat atgaatacca aaaaaagaag 2612041 taacaaaaag ccgcctcttc aacaggcggc ttatttgctg cttttttctt tttttgaatc 2612101 ggcaccgttt tctttgctgc tcggaagctg gacagaaggc gtgacacccg agccgccgct 2612161 tccattataa aactgcggca cttcgccctg cactgcttta atcgatacag gaacattatt 2612221 tgtgacgaca gcggttttgc tggcaaatgg aatgatgacc ttcactttaa tttcgacaaa 2612281 gatgctgata tcaataagtg cgttatttat gccatacggc ttgattttgg ttttgacatc 2612341 tgtaaaagcg tcaccgatta aattgaaccg gaccgggatt ttcggcccga ggtttccaag 2612401 aaggctgttg ccggttacct gtcccagcgg aatgttgatc ataatgtttt cactggcgcc 2612461 gctgtgtccg gtatgggttt ccatctcttt caaatgagcc tgaagctgct ttgtcacttt 2612521 tgttttcaca ctgtttacaa cctgtgtatt aaaatcgatt gtcgttaagt ttccgttttc 2612581 atcagaattc atttgaaaca tatctttcat attttcactg tcagacatat agtcctcaat 2612641 cgaatcctgg atcacctctg tcgctatacg cttcgtttcc atctcgccga tgtccattaa 2612701 aacaggtttg atcgagccat tgatcatcca aaggctgacc gttgttgaca ggataaaaaa 2612761 gacaacggac aggagcatca cgtaacggaa aggcaaaggt cctctcttgc gaaaagggcc 2612821 gcgatatctt ggcaagaaaa tcccccctta catatcacaa tgtatgcttg taagagggga 2612881 catagtaata gccggggcca atttatttta tttcatcatt tttaaaagcg cttctctgcc 2612941 gctcatgccg actttgatgc caagatcttc cgcagcgtac gtgacggatt ctaaaggtgc 2613001 gtctaacagc tggtcaatgg tgcggacacc aactgcgcgt cccgccacga tgccgcgctc 2613061 ctttaatttt tcattcagca gcgccacatc aagcgcgccg cacataatgt atccgtgatc 2613121 attggcgacg gccataaaat tcgttttggg aagctttact gtcacagctg taaaaggctg 2613181 tccttctatc atgatcggtg tcaggtttac cacgtcaacc actcccttca ttcatcactt 2613241 tatgatgaag ggcacagctt gttgtgggct gactgcctta ttgtgcaagc ttccaagcaa 2613301 gcagatcccg caaaaattcc ggcataaaat attctttttc tgcagcgtcg cgaatcaacg 2613361 gaaacagttt gccgagcgta aacatatcaa gcaccgcaac ggagtattgt ttatgttttt 2613421 caatatcttc cccgttcagt gtgatccgag tgacgtgggt gatcccgtca tcgagccgtt 2613481 tcgtttctac ctcaacgccg gcatacacca ttttccccat cacttctccg cggaagccga 2613541 gtcctttgat ccggagctgc tccatttgtt cggaagcggc atggacaatg gtttccttca 2613601 gttcttctcc cgtcaggcgg acagccaccg ggttgatcgg atgcggacag atgcggtgca 2613661 gatccagctt tgtcacagga cctgctttta gcggaccgag aatgacacct gaattgacca 2613721 tactgatgtc cgtctcgcac cattccttta aggcgtatgc caaaagcaaa ggcagctctg 2613781 attcttcaaa ccacttcacc tcagcatctt gtgcaagctc tgcaacggca tcggacagtt 2613841 tctcctcggc ttcacgttct ttttcattga gaaacgcttt agtttctgcg gattctcctg 2613901 tccattccgc catgttctgc acagaagccg ttttgctgtt gatgcttcgc tgtacgctgt 2613961 ccaccgtgat ttctacacag ccgacataat gcccgtattt ctcggcgctg gccagcagta 2614021 ccccattaac cacttgtcca tcttcgagca aatgatgggt atgtgattcg aggattacat 2614081 caatctcagg caccgcttca gccactgctt gatcatcaag aatgcctaaa tgtgacagca 2614141 gaacgataat atcagcctgc cctttcactt ccagaatggt ttcctttatg ctttcaaggg 2614201 catccgtaac tgtccatccc agcttgtcat atacaggata atacggcaca gttacaccta 2614261 agaaagcaat ggacataccg tttttcaatg atttgatatg gtaaggcacc gcccaggacg 2614321 gacggtttcc atttttatca aacaggttag agacgatgac aggaaattca gcatgatcat 2614381 ataaggcagc aagctcttca tgcggaagcg taatcccttc gttattgccg atcgccgctc 2614441 catcaatgtg aaggcggttt aagagatcga cattcgcttt tccgaatgtc gcctctgtca 2614501 cgaattgaaa acgatcaaga tgatcgccaa tatcaaaaac gagcgtctct tcgccgtctg 2614561 actgatgctc ttttcttttc tgctcgatat aatctacaat tttcggccag ttttcaaaat 2614621 ggctgtgcaa atcatttgta tgatataagc ggagcttctc cttcataata tctctcccta 2614681 atcgttcagc tgaaaatgcc ttcataaatg agctggcagc cgatcaaaat caatacgatc 2614741 cgcatgatca taacgatcgt tttcgtctgc atttttctgt tgatggcggc gccaagcttt 2614801 ccgccgaacc aagcgccggg cacaagcgcg agggcgtaca gccaattgac gtgcccggaa 2614861 atcatatgtg aaacagaccc tgtcatagaa gacaggaaaa taataaacat ggacgttgcc 2614921 accgcaacct tcggcggaaa cagaaataac agcatcatcg ccggaaccat cagtgatccg 2614981 ccgcctatac cgaaaagtcc gcctaaaaaa ccgacaacaa aggcaatggc aataccgaca 2615041 gaggcctgat atgagtacgt ataaggctca ccggcatcat cctgaaatgt ccggataatt 2615101 cctttgtgcg ctttgttgat tggccgggct ttcgctttca gcattaagga taatgaaatc 2615161 agaatcataa aaatgccaaa ccaaacggaa aacgagtttg aattgaacag ctttgacacg 2615221 taagccccga tcatgctgcc gggacccgaa ccgataaaga aaatgagtcc gctcttataa 2615281 tcaactgttt tatatttaat ataagccaaa gttgaagaaa ggcccgtaaa aataatgacc 2615341 aaaagcgaag ttccaatcgc aacctgcggc gtcacatcct gaaacagctg cgtcactgtg 2615401 cttaaaaaca tcagagatgg cacaatgaca attccgccgc caagcccgat cagacttcct 2615461 accgtacctg cgattaatcc cagtacgacc aaaatcacaa acgacatcaa tcaaaacctc 2615521 ttttctaaaa taaatcgagc tgtctcggag caagtccgct gtactcgata tcaagcagtt 2615581 caagcatctg cttgccatta tccgcagcgt caccgccgga attgttgttg aacaggacaa 2615641 aaacatcctt acattgctgc tgcaattcat tcaggtgctt tttccaatcc tccagctcct 2615701 gttggttgta gcggtataag tacctgacct cccgccagtt tttcccgcca tcaggcttca 2615761 tccagccctg cttgttgcgt ccgtgaaacc tgacgagcgt tttgttttca tcggtcgcgc 2615821 gcaacacggt cggaacgctg ccttctccga tttgcggttc atcacagaca ctgtgaatcc 2615881 agccttccgc tttcataaat gaaagcgtct gctcataaaa tggcggcgag aaccaggaac 2615941 ggtttctgaa ttcaagcgcg caaggaatat ctcccatttg gtgcttacac catctcaaat 2616001 aggcgacatt ctccttcttg cagtcaaacc acggcggaaa ttgaaacagc accatggcga 2616061 gcttattgct atgtaaatat ggcgttaaag acaccttaaa cgcatcaaac atctcctctt 2616121 ttgagtcaaa gggaatttcg ccgcgctgat gccctgtcat gccctgatat gctttcacga 2616181 taaattggaa ggtttcgggc gtttccttca cccacttttc attattgcgc gccggctgaa 2616241 tcgcgtaaaa gctcgcgtct aattccacga tcggaaaatg ggaggaatag gcctgcaatt 2616301 ttttctggct ggccgttttc ggcggataga tgctgtcatg atccccccat cccgtcagtc 2616361 cgatataaat cacactcatt cacctctctt ccagtttatc acacgtgttt tcaggtttcc 2616421 tcggaaatgc tgttcatatg gcgggaaaat gcctcacgca aatgctgata ttgttcctca 2616481 ttcgtatcta aaaacgcctc ttctcttgag gaaggaatgt gctgatattc aataggcgcc 2616541 tgaaactgct cactcgtaaa atcgtacacc acaccattga tgctgttata aaaatgccag 2616601 ctctcatcga ctcttgtttt gaaaatcgtg ccgccgaaat ggtcttgaat caccaatgcc 2616661 gtcacgccgc attggccgca tgacgggcat tcttccgtcc atttagagct cgaatggcgc 2616721 gaccaggatt gcttaagtat gtatttgaca tgctccattg cctccgcctc ctttaaaaaa 2616781 agataccacg ttgatgagat tttaaaaact agaacggagg aaatcaaaaa acccggcggt 2616841 aaaatccgcc gggcttacga aggaacgacc agagctccgt caatttcagt gactttttcc 2616901 ccatcattgt acacgcaccg gcctttgctg taagtggccg aaatgctgca gggaaatgta 2616961 tgtccttcgt aaatgctttt tttatgcttt gcaaacatcg attctcttgt aacagtgtac 2617021 ggctccatgc tgacgagcac gaaatctgca tcacaccccg cctcaagccg cccttttttc 2617081 tgaaggccga atcgttttgc aggggccgcc gctgtccatt ctgcgatggt ttcaaatgga 2617141 atctgatgct caagcgccag ttccagcatt cctaataaag tgaactgccc gccgctgatt 2617201 ccgccccatg ataaaaacat gttatcctcc cgcttcaagg atggacggca aggggaatgg 2617261 tctgaggaaa ccatgtcaat gtccccggca atgagcgtct cgatcagcgt ctcttttgat 2617321 tgccgtgacc ggagcggagg cgcgcatttt gcgacagagc ccctttgccg taaatcgtca 2617381 tggctgaaca agacataatg cggacatgtt tcaaccgaaa catcaagacc ttcctgtttc 2617441 gcctctctga tcagccggac cgctttcgcc gtgctgatat ggacaaaatg aaccggacag 2617501 cctgtcacct tcgcatactg aatcgtgcga tacaccgctt caacttctgc ttcctccggg 2617561 cgggaggcgg cgtacgcatc cgcatccacc tttcctttat tggccaaaac catctgcaag 2617621 tagcttgtga tcgcgtcgct ttccgcgtgg agagcgagga tttttcctgc agccgcgatt 2617681 tctgccatgc ctttgagcaa tgtccgttca tcaacagagc ggaactcatc agtgcctgac 2617741 tttgataaaa acgctttaaa cccgatcgct cccgcttcag ccatcggacg gatgtcctcg 2617801 atatggcctg gcacaaggcc gccccatagc gcaaaatcca cggcagattt ttgcctgcct 2617861 agctcagctt ttgcgagaag atgctctgcc gtcacggttg atggaataca gttgagcggc 2617921 atatcaaaat aggtagtgca accgcctgcg gccatcattt gagaacctgt ttcaaacccc 2617981 tcccaatcct ccctgcccgg ttcattaaaa tgaacatggc aatctatcac accaggaaac 2618041 acgtatttcc cgtctgcctg gatgatttcc gtcccgcttg cttcaatgtc agaacctatc 2618101 tcggcaatga caccgttttg aactacaata tcagcttcta taacgccatc tggcgtaact 2618161 gccttcgcac cttttatcac catatcgtaa gccatattga tccccccatg tcaggatgac 2618221 gattttccat gtcagtttat gtaacacaac cagttctatt ttcaacagtt tactgctact 2618281 atgatcgtat tacatcagca aaaccgctag aattcctatt gaaaattatt caccttaacc 2618341 aatgttttta tagaaaagga gaatgcgcta tgaatattct tgatgtgatg aaaataccgg 2618401 cttttgaaaa cgccaattta atcgctggaa aagcaggagg ggaaagagag gttcagcatg 2618461 tcaatatgat ggacgctccg gatatcgtag actttttgca taagaatgaa ttgctcgtca 2618521 ccaccgccta tcacctgaag gatcacccgc atcaattatc tgaactgatt cggcaaatgg 2618581 caaaacgcgg ctgcgcgggc ctcggcatta aaacaaagcg ctatctggaa gatatcccga 2618641 aggaaatcat cgaactggcc gattcatatg cgtttccgat cattgagctt ccggaacaca 2618701 tccgactcgg cgatattgtg aatgccacac tcagccatat tctcgatatg cgttctaacg 2618761 agctgcagca agccatttac gcgcacaaaa aattcacaaa ccacattatg agcggcaagg 2618821 ggctgcaatc cctcctcaaa aaggtgtcag acatccttca gcttcccgtg ctgctgcttg 2618881 accagcatgc caaaatgctg tctgcgtctc atcagatttc agttgagacc gaaaagctga 2618941 aaggcaccct gaataccgta tccgggccat ttttcacttg tttctctaca atctcagatc 2619001 agaaaacata ttctgtcctg cctatttata atcacgaaaa aaactgcggc tacctgctga 2619061 tacccgacat ggtgcaggca ggcgacaaag gattgatcct cacgattgaa caagcggcca 2619121 acgtcatttc ctttgaactg ctgaaggaaa atgcgctgaa gcagttcagc cggcgggccc 2619181 gcaatgagtt tttcaacaat tttattgagc ggaccttttc ttcagatgac gaaatcaaaa 2619241 accgggcgaa agaattcaag ctgcgctggg atcaaaaata catgtgcatc gccggcaaac 2619301 tcgatcgcaa tgacgaatca atcagcttta cagaaaatca gctcgcttcc gacagcgtat 2619361 tcgaatttct tgaaggtgaa ttatcagcct tcccgtttcc acctcacttc tttatgaaag 2619421 gaaatgtcgg cattattcta atcgaggcga cagacagctg gagtgaaatg cacgcctcgg 2619481 tgatcagctt tttagaacag tttcaaacac aggtcagcgc tcaatttaaa cgaaccgtgt 2619541 cctttggcat cagcaatatc tgccaaaagc tcattgatgt tcccgacgct ttcacagaag 2619601 cttctgatgc tctgcaatcg gggcatttgt caagaagcac cgcatttatc caggtgtatc 2619661 acgccaaaga tgtgcctgag cttctgcgct tgctcccagt tgaggatttg aagaaatttt 2619721 acaactccac gcttcagagc ctcgctgaaa aacagcagga ggatcaaagc ctgcttcata 2619781 cgctttccgt ctatttagag acacactgcc aaatttcaga gacggcaaag cgtctgtacg 2619841 ttcatcgcaa tacggtcata taccgccttg aaaaatgcga agagcttctg gggaaaagct 2619901 taaaagatcc tgaaacaacg atgcgtttgc ggcttgcatt acgtatgcag cggctgatca 2619961 gctaaagttt gttacatttt cttacaaaac gaatcgtttt tcgtcacttt cagcaatcac 2620021 acctgtcttt ttcagctact gtatccaatg acacccctcg accggaacga tattatgtta 2620081 ctaaagttca catacaggga gggactatag tgaaaaaaag atcgtttaag gtgtttacac 2620141 ttagcctgca gcatgtgctc gccatgtatg caggtgcgat tttggtgccc ctgcttgtcg 2620201 gcagggcgct gaatgtaaca actgaacagc tgtcctacct attggcgatt gacctgttaa 2620261 catgcggcgt cgctacgctt ttgcaaacct tgcgcggaac atacatcggc atcgggcttc 2620321 ccgtcatgct tggcagttca tttgtggccg tcaccccaat gattgcaatc ggcagcaatt 2620381 acggcattca cgcgatttat ggttccatca ttgcggccgg tgtgttcatc tttttgtttg 2620441 cgcgtttttt cggcaagctg actgtgttat ttcctcctgt cgtaacaggt accgttgtga 2620501 ccttgatcgg cctttcactt gttccgacag gtgtgaaaaa tatggctggc ggcgaaaaaa 2620561 taaacggcag cgccaacccc gaatacggtt cgctcgaaaa ccttcttctc tctgtcggtg 2620621 tccttgttct gatcttagtc ctcaaccgct ttctcaaagg atttgcccga acactgtccg 2620681 ttctgatcgg catcgccgcc ggaacagcgg cagcagcgat catgggcaaa gtcagctttt 2620741 cttctgttac agaagcaccg ttcttccaaa tcccgaagcc tttttacttc ggagcccctg 2620801 cgtttgaaat cggtccgatc ttaacgatgc tgatcgtcgg aatcgtcatt attgtggaat 2620861 caaccggcgt tttttacgca atcggaaaga tatgcggcag acctttaact gacaaagatc 2620921 tcgtcaaagg ctatcgagcg gaaggaatcg ccattctcat cggcgggctg ttcaatgcct 2620981 ttccttataa tacctttgcg caaaacgccg gcttattgca gctgaccaaa gtgaaaacaa 2621041 gaaacatcgt cgttaccgca ggctgtatcc ttgtctgtct cggactgatt ccgaagattg 2621101 ccgcccttgc atctgccgtt cctgctgctg tacttggcgg cgcgaccgtc gtcatgttcg 2621161 gcatggtgat tgcctccggc gtcaaaatgc tcagcacagc ggatctcaaa aatcaatacc 2621221 acctcctgac catcgcatgc tcaatcgcac tcggcatcgg cgccagcacg gcccccggga 2621281 tttttgctga attccccgct ccgatccgga ttctggtcag tgacggcacc atcaccggaa 2621341 gcctaaccgc catctttttg aatctatttt tcagcttgcg cgacaaaaaa gaattaacag 2621401 cacagcaaac agaacttccg gtattagaac atacactcgc attagaaaaa gaggtgtaaa 2621461 aaagatgaag gaacagcaca atgccttaca gctaatgatg ctggggcttc agcacatgct 2621521 tgccatgtat gcgggagcca ttctcgttcc gttgatcgtc ggagcagcga tcgggctgaa 2621581 tgcggggcag ctgacgtatt taatcgcgat tgatttgttt atgtgcgggg cggcaactct 2621641 tttgcagctc tggagaaacc gatatttcgg catcggcctt cccgttgtgc tcggatgcac 2621701 gtttaccgca gtcggcccga tgatttccat cggaagcact tacggtgtcc cagcgatata 2621761 tggtgccatt atcgccgcag gactgattgt cgtcttagcc gcgggcttct tcgggaagct 2621821 tgtccgtttt tttccgcctg tcgtaaccgg atcagtcgtc atgatcatcg gcatcagcct 2621881 gattccaacg gcaatgaata acctggccgg aggtgaagga agcaaagaat tcggctcact 2621941 cgacaacgtg ctcctcgggt ttggcgtcac agcttttatc ttattgctgt tttatttctt 2622001 taaaggcttt atccgctcca tagcgatttt actcggtctt atcgcaggaa cagcggctgc 2622061 atatttcatg ggaaaggtcg atttttctga ggttttggag gcgtcttggc ttcatgttcc 2622121 gtctctgttt tatttcggac cgccaacctt tgagctgccg gctgttgtca cgatgcttct 2622181 cgttgcaatt gtcagcctcg ttgaatcgac aggcgtttat tttgccctcg ctgatatcac 2622241 aaaccgcagg ctgtcggaga aggatctgga aaaaggctac cgggcagaag gccttgcgat 2622301 tttgctgggc ggcttattta acgcgtttcc ctatacagct ttctcgcaga atgtcggcat 2622361 cgttcagctc tcaaagatga aaagtgtcaa cgtcatcgcc atcacaggaa tcatactggt 2622421 cgcgatcggg ctggttccaa aagcagcggc cctgacaaca gtgatcccca ccccagttct 2622481 cggcggcgca atgatcgtca tgttcggcat ggtcatttct tacgggatca aaatgctatc 2622541 cagcgttgac cttgattcgc aaggcaacct gctgattatc gcctcttccg tcagcttggg 2622601 gcttggcgct acaacagttc ccgcgttgtt ttcatctctt tcgggcgcgg cctctgtctt 2622661 ggcaggaagc ggaattgtga tcggcagttt gacggccatt gcactgcacg ctttttttca 2622721 aaccaaacag ccgaatagcg cagacataaa aacgtaaagg aagatgccaa tgttcacaat 2622781 ggatgacctg aaccaaatgg acacacaaac actgacagac acacttggct ctatttttga 2622841 acactcttca tggattgcgg agagatccgc agcactacgg ccgttttcgt ccctttctga 2622901 tcttcaccgc aaaatgactg gcattgtaaa agctgcggat cgcgagacac agcttgattt 2622961 aatcaaaaag catccccggc tcggaacaaa gaaaacaatg agcgatgact cggtacgaga 2623021 gcagcagaac gcagggctcg gcaaattaga acagcaggaa tacgaggagt ttctcatgct 2623081 gaatgaacac tattatgatc gcttcggctt tccttttatt ttagcggtga agggaaagac 2623141 gaaacaggac attcaccaag ccctgctggc aaggcttgag agcgaacgag aaacggagtt 2623201 ccagcaggcc cttatagaaa tttaccgaat cgcccgcttt cgtctggctg acatcatcac 2623261 tgaaaaagga gagacgcaaa tgaaaagaac catgtcttat ggcaaaggaa atgtatttgc 2623321 ataccgaacg tatttaaaac cgctcactgg agtgaagcaa atcccggaat catcttttgc 2623381 cggaagagat aataccgttg tcggcgttga tgtgacatgc gaaattggcg gagaagcctt 2623441 cctgccatca tttacagacg gagacaacac tctcgtcgtg gcaacggatt caatgaaaaa 2623501 ctttatccag cgccatctcg catcctatga aggaacgaca accgaggggt tcctacacta 2623561 tgtagctcac cgatttttag atacctattc tcatatggac acgatcactc tgactggcga 2623621 agacattccg tttgaagcaa tgcctgcata cgaggagaaa gagctcagca caagccgcct 2623681 cgtcttcaga agatcgcgta atgaacgaag ccgctctgtg ctgaaagcag aacgaagcgg 2623741 gaataccata acgattacag agcaatacag cgaaatcatg gatcttcagc tcgtcaaggt 2623801 gagcggcaac tccttcgtcg gcttcatccg ggacgaatat acgactctcc cggaagacgg 2623861 caaccgcccg ctgtttgtct atttaaacat cagctggcaa tatgaaaata caaatgactc 2623921 atacgcttct gatccagcac gctacgttgc ggctgaacaa gtccgcgact tagcgagcac 2623981 cgtttttcac gagctcgaaa ccccttcaat ccaaaaccta atctatcata tcggctgcag 2624041 aatattagcg aggttcccgc agctcactga tgtcagcttc caatctcaaa atcacacgtg 2624101 ggatacggtt gtcgaagaaa tcccgggctc aaaaggaaaa gtctacaccg aaccgcgccc 2624161 gccatacggt ttccaacatt ttaccgtgac aagagaagac gccgagaaag aaaaacagaa 2624221 agccgctgaa aaatgtcgga gcctgaaagc ctgatgggaa aactgacaac ccatatttta 2624281 gatttaacct gcggcaaacc agcggcgaac gtaaaaattg gattgaagcg gctgggcgaa 2624341 agtattatga aagaggtata cactaacaat gacggcaggg tcgatgtccc tctgctggct 2624401 ggtgaagagc tgatgtcagg agagtatgtg atggaatttc atgcaggaga ctattttgcg 2624461 agtaaaaaca tgaacgcagc cgatcagccg tttttaacca tcgtcaccgt ccgttttcag 2624521 ctagcagatc cagatgcaca ttatcatatc ccgctcttgc tgtcgccgtt tggttatcag 2624581 gtgtataggg ggagttaaga aggaagcccg cctcaccggc gggcttcttt ttgcacttca 2624641 attaactttt gatcctagga cagtacttga agtgatcccc acacttagtg aaacaacagc 2624701 tagaataaac attcacctat atttttcagg ataattgcct acgagaaaaa taccctgtag 2624761 tcctttcatt tataaatcga ggtttcaaac taataagtca gctcttagca gccgagctcc 2624821 cttctccaat cctataaaca gaccgcgttt tttctcgaaa aaatactctg aagacaattg 2624881 ctgcgttttt aatagttttg ataacgcgtt ctctcttaca cctttagaca aaatattcat 2624941 tttttctttt ttagacttaa atctatgtcg aaaataatcg ttggcatatc ttatcctatc 2625001 tccactaaag gaggtgacat tatgggattc tacaattctg gtggatacag tggaaactct 2625061 ggttactcaa acggtttcgg gagctccttc gctttgatcg tggtgctatt cattttgttg 2625121 atcattgttg gagcagctat ctttaattat taagtttaac tttccttgcc tccgccgtat 2625181 ccaacacctc cctgtccgac agacgccata agaagttttt atggcgtctt tgctatgtgt 2625241 tcactaatct ttttgtaatc cagaagctgt caagttctac gagatttatc gtgtgttttc 2625301 ccacaacgct tctgcgtctt gatcgcgctg tctgactgag gctaaaaaag tccggctttt 2625361 aaaagccgga ctcccgtcta cccccgttca actctcttct aatcctgcaa gctgaccgca 2625421 taatcccgcc atacccggta caccggcaca aattccccgc cagcccttct tctatatctt 2625481 tgtcagaagg ttgaggggtt tcccgaaaca atgctttaag cgcaatgatc attcccggcg 2625541 tacagtagcc gcattggaag ccgccttctt ccaggaaagc ggtttgacac atatccagct 2625601 cttctttttg aagcccctcg atggttgtga tggaatggcc gtctgcttga taggccatcg 2625661 tcatgcacgc attggccagt tttccgtcga ttaaaataga gcaggctccg cagcggccga 2625721 ttccgcagga cacctttgtc ccggtcagct gaaattcctt tctaagcagg tcactcagat 2625781 gtgtcgtagg aacggcagca acctcccacg cctgaccatt cacggtcatc cggaactgtt 2625841 ccttttttac aggaaatggc ccggcctctt ttatgtccat tgcttcagcc cctttctgtc 2625901 gatcgcttca agcaactctt ctcttgaaat tggcagcttg tttatccagc atccgaccgc 2625961 atcatgtact gcctttacaa tcgccggagt gatggcgatt gttccgattt caccaacacc 2626021 gcgcggtcca tatacgtctc ccttcattaa gtcttctatt gcaatcagct tcatgtcagg 2626081 aacatctttg attccgggaa tcaaatagtg atcgagattt tccgcagcat aacggccatc 2626141 cgtcattttc gcttcctcca tcagtgtgta gccgagtgcc atggcagcgc cgccttcaat 2626201 ttgacctcga tatccctgcg gactgacaac cggacctgcc gcaatagcgt gctcacaatc 2626261 tatcaatttg acatcgcctg ttaacagatc tacctccacc tcaacggcag ccgctccaaa 2626321 tgagtagagg aaatggccgc ccaccacagg atcaggcgtt gttggaaagt caaaggccgt 2626381 ttcctctgcc aaagggcctt tttcagccag ctccttatac gtcaccacga gcgcctttgt 2626441 gtttttgtca cgcaagcctg cagcgccggg aataagattt tccgctgaac agccgctcca 2626501 ttctgccgcc cgttttttca actgagctag aaacggcttc ttcaaacgct ggatcgcgtg 2626561 ccacaccatg cttgtgccgc gggatgctgt ggaggagcct gacttcggca cttttgcggt 2626621 atccccaata acaatggaaa tatcctctgc ggcacaaccc agctcctcca tgacaatctg 2626681 ttcaatcgct gctagaatcc cctgtccgca ttcttcaaat ccaaacgaag cagtgatttt 2626741 gccttcactc gaaagagaca aacggcctcc tgccgcatcc attcggccaa accccagccc 2626801 gccgccgtgc attgtaattg ccgctcccgt gcctctttgc agatacccgc agttccggct 2626861 tgttttttta agaatgggag atttagatat ggcattcaac acctgtgccg ctccgtcagt 2626921 tggtgcaatt cgatgctcaa gcggccccaa gtcatgcggt tttctgatat tttttcttct 2626981 cagctcgagc gggtcgatgc caagcatgcc gctgagacga tcgagatggg tttcgagtgc 2627041 aaatgtgatt tggttgccgc caaagccccg aaattccccc gccaccccgt tgttcgtaaa 2627101 tactgatatt ccttcagtcc ggatattcgg aatacggtac ggccccgcgg catgctcgac 2627161 agaaaaatca agaacagccg gtccgagcgt agcgtaagcg cctgtgtccg ccacaatttt 2627221 cacgtcgtgc gccaatagat ttcccgaatg atctgcaccc gtttttatcg taatcttcat 2627281 cggatggcgc ttaatgccag aacgtacaga ttcctttcgt gtctgatgaa ttttgacagg 2627341 gcgtccgctt ttcagggcca aaagcgcagc atacggctga atattcagct catccttccc 2627401 tccgaacgag ccgcccatcg gacttgacac aattctgatc ttctcttcag gaatatcaaa 2627461 aatacgggca agctggaaac ggtctttata gccgtgctgg gttcctgcat acatcgtaaa 2627521 acccccgtcg tcttccggaa cggctacacc tccctccgtt tccatatacg tatgcatctg 2627581 ccgcggcagc tcataggttt cttcaaagac tgtgtcagat gcttgaaacc cttcttccac 2627641 atcaccgttt gaaaaaaatg cgcggtgcag gatattcccg tcctcatgca gtctttgcgc 2627701 attcggccga agcgcttttt ctggtgaatc catgacttcc agctctttat actcaacttg 2627761 aatcagctcc agcgccgctt ccgcgatttc ttccgtttcc gcagcaactg cggcgatcgc 2627821 atccccgaca taccgcaccc tgtcctcaca taaaaccggc tgatcaggga tgacaatgcc 2627881 aaatcggttt aagccgggaa cgtctttatg tgtgacgacg gcctgcacgc cttccatttt 2627941 ctcagctttt atggtgcaaa ccgacacaat ctctgcatga ggataagcac ttctcagcac 2628001 cttgccatac agcattcctg gaaagctgag atcggtcata tatttcaatt cccctgtgac 2628061 cttacccctt ccatccggcc tgactcttga cggtttgttg atgatcattt attcccctcc 2628121 ctcagccatc agctctgcca tgatgacgtt ggcagcggct ttttttctgt atgccgctga 2628181 cataaaaaca tctgaggaaa acggcagctc atggataagt gttttgtaca gctcatgcgg 2628241 gtcccaccct ggtgccatcc atttcgcttc gctgtccaat aatctcctag gagtgatatc 2628301 ggcatggcca gcggcgaggc gaatgctgcc gtctttcaaa aaacgtccag ctgcaacagc 2628361 agccgctccg gtaaaagcct ggcgccttcc aagcttgtga taaaatacac gctctccctc 2628421 cgcccgcggg atgatgacac gcgtgacgat agccgttcta aagtcttcct cactgagcca 2628481 agcgccaagc ggcagcctga ttagctcctt ttgatatacg ataagctcag caccaagcac 2628541 aagcagaagc ggaatgaaat caccgatttt actcgctatg ttgccgccaa tcgtggcacg 2628601 gctgcgaatc cccggtgcag cgacagcgga agcagcgtca ctgaaacagc taagcgctct 2628661 cttaatcaaa gggttctttc tgcattcatt cagtgatgtg agccccccga tcgacacgtg 2628721 ggtgtcactg gtgctgatcc ctcgcatttc gtcaatccct tcaaggctga caaggtgctg 2628781 tttcggtaga gttcctttgt cccactgaag ctgaaggagc gtgcttcccg atgcggcaca 2628841 cacatccgga gcaagcttct ctaaaagcga ataggcctca tcaagcgctg ccggtctcca 2628901 taattgaata ttcatccttg cttttgtcac ttggccgttc aagacatcgc cctccttacc 2628961 atgtcatatt cctcgggtgt atcaatatcg tccaactcac cgctatcctt tgcctccaaa 2629021 accgctcctg ctccaagctg tccgcttttc aggagcctgc gagccccttc atctcccttt 2629081 aatcccttta cataaggaaa acatgtcgac gagaagtaga ttggcggggt gaacgcccct 2629141 aaaaacgatg acacggcaaa tgactcagga gccagagcca caagggcatt gagatgatcg 2629201 acggaaagct gaggctggtc ggctaacaaa atgacaatgc cgtccgcccc catgctttct 2629261 gcttttctca ccccgctgct gactgaatgc ccctgaccct tttctgcgtc ttggcaaacg 2629321 tgcaggctcc agcgtttttg aaaaggcgga gcgtgatacg gcgctcctat ccactcaagg 2629381 gaggcatgtt ctgtccgctc gacgaccagc acgtgatcaa ggcgggacga cagagcagtt 2629441 ttcaaggaaa gtgagcctat gttttctcct tttagcggca aagccagctt gttttgtccc 2629501 attcttctgc ttttgccggc agcgagaaac acgccgatca gataggggct tctcatacaa 2629561 ccgccacccg ttttcttgtt tgaatgattt ctgcaactac acttaccgca atttcctcgg 2629621 gaccttccgc accgattttc agcccgaccg gactgtaaaa gtgagacgga ggatgttttc 2629681 cgctcagcag ccgtttcgtg cggtttgccg aacccaacag tccaatataa tggaggtttt 2629741 gagaaaataa gaagttgatg atcgtttgat cgtgctgata atgatgggtt gccacaacag 2629801 ctgcatcatg cggaaaaaat tgaaattcgc taagcatttg ttccggaaaa gcggtgatca 2629861 gctgatccgc ttttggaaaa agagaggatg tacaataagc gggccgccaa tccgtcacga 2629921 taacagaaaa ccctgtgtca gccgccaaat tggccagcgg tacattatcc ggtcccgccc 2629981 caaacagaat gagacgcggc ttcggttcaa ttcgctgaat aaacatgtta gtggtttgat 2630041 cgaaatgcgg taaatgaagc gttgaaacag tacgttgaat atcttgcaga ggcgcgtccg 2630101 gccagttccc aaaatgtccg ttctccgtca gaaataaata atgggaggat tcaatcttta 2630161 taacggaagt gacagctttg cctgaatgaa ggcagtccct cactttctca tagtgccgcc 2630221 ttttttcctg agtgattcgc tctgcatgaa catgaataat gccattgcac ccggctccca 2630281 tgccccaaga aagatcgtcc tccgaccgca tgtcgtaggg aatcagcgtt gatgtgagct 2630341 gatcgcccag cgcactgatt ctttggaata catcttcttc cacacacccg ccgctcagca 2630401 agccaatccg tctgcctttt ttcttaaaga gcatagaggc gcctgctttt cgatacgcgg 2630461 agccttcaac ttgaacaatt gtcgccagta cagcctcctc ctggtcttcc aggagcgcat 2630521 ctaacatcgt gtgaaaattc cccaatgccg catcctcctc tcgaaaattg ccgtgagaaa 2630581 caactagttc agcgtgattt tataggtaac ttgtataaag aatagacgat ggaagaaaaa 2630641 atgactcatg atttgtcaga aaatgaaaca catagaaaga ggatttgtaa aaagagtcaa 2630701 acgaagaaaa tcagattgga gaaaacacga aatcatatcg ttaaaaagct tgcggagttc 2630761 cgcaagcttt tctttacacc gctgcctggc ggccagcgtt ttcatacaca tccagcgctg 2630821 cttggagcgc ttttcctgct tcgattcctg cgttatgtct gagaagcaca gcctctaacc 2630881 cggcaagcac gaatagcacg ttttcttttc tgcagctgta ccccatcgtg ccgatcctcc 2630941 agatcttccc tgcaagcggg ccgaatgagc tggcgatttc aatgccgaat tgtgccagca 2631001 gcatgtcacg gacagactcg ccgtcaatgc cgccgggaat ttcgacacag gtgacaacag 2631061 gcattttgca gctgtcatct ccaaacaatc ttagccccat tgcctttatc cctgctgcta 2631121 atgcggcttc atggtgccga tgccgctcga aacgcgtctc aagaccttct tcaagcacca 2631181 gtctgactcc ctcacgtaag gcgtacagca tcgtcgtcgc ttctgtatga tgattgagcc 2631241 gtctttcgct ccaataatcc tcaagctggc tcaaatcaaa gtagttgctt gtaattggcc 2631301 gatttcccga aagtgctgcc ctgtcagctt gtgtcgcaat cccgcgttcc acctttttgc 2631361 gagctgcaat cacgtccgcc acccgctcat tatatgtaat cggcgccatt cctgaaggca 2631421 cagacaaaca tttttgcgtt ccgccgatgg cagcgtcaat cttccattca tcgactttaa 2631481 cctcgcagcc cccaatcgtt gcgactgcat cgacgataaa caatgcatcc tcggtgcggc 2631541 aggcttcgcc gatggctttc agcgggtgaa tccgtcctgt cgatgtttct ccatgcacca 2631601 tggccacaat tttcggcttc acttttttta tctcccgtat gatgtcctcc gggtcaaaaa 2631661 ccgttcccca ttcgcactcc agcatatgaa catttgcccc atatcgctcg gcgatttcag 2631721 tcagcaaata accgaaacgg ccgtaaatgg gaatgagcac atcatcttcc ggctctatca 2631781 cactagccag cactgcttca attcccgccc gtgaagtgcc gtcaatcggg tatgcccagc 2631841 ggttttttgt ttggaacagc tcccgaagca tctccatcgt ttcattcata atacctgtaa 2631901 acgccggatc aaattggccg acaaccgggg tgctcattac tcttaataca cgcggatcaa 2631961 cctcaacagg ccccggtgtc ataatcgttc ttaacggggt gcataattct cttctgcctg 2632021 acacagccat tcctccttta tcagtaagcc agtttgtata ataaatcagt cagtgcgcgg 2632081 acgccgatct caagctgtct ggctgacgta tattccttcg gtgagtggct gacgccgcct 2632141 cggctcggca caaacagcat acaagcagga tagcgccttc cgatcatttg cgcgtcatgc 2632201 cctgctccgc tcaccatttc ctcacagctg aagccgtttt ctaatgctgt ttcaaaagcc 2632261 gcagccttca gcctttcgtc catcggcaca ggctctatcc gcatatattc atcaatcaca 2632321 gcgcgaattc ctttttgtag gcaaatgccg ttgatcaaag caaccatgtc ttgatgaaac 2632381 tgttccagca catgctgatg ctgatggcga atatcgattg aaaactggac gcggcccggt 2632441 atgacattgg ctacattggg ctctgccgtt atttttccgc atgtcagacg gagctcatcc 2632501 ggcagctcat ccgaccgcag cagcagctca tgaatgatac ggctgctggc tgcgagcggg 2632561 tccttgcgcc atttcatgga ggtggttcct gcgtgattgc attctccttc gagcgtgacg 2632621 agatatcgtc tctgccccgc aatacttgtc acgatgccga gatcccggcc tgacatttcc 2632681 aacgtcttcc cctgttcaat atgcagctca acaaacgcgc tgatatctgt cctatatgct 2632741 gactgaaaca cacctttgcc aaaaccgctc tcatgcatcg ctgtttggag ggagactccc 2632801 gactcgtctc ttggctcttt tgcatcttgt tctgaaaaaa cacccgtcat attccccgac 2632861 ccccaatagg tcattggaaa acggctgcct tcctcctcac ataaggagac cgcctcgagc 2632921 gttttttttg gcgctccgta tgtttccttg agctgcttta acgcgagcat tgccgccaga 2632981 acgccatagg cgccgtcgta ttttcctcca ttgatgacag tatcgatatg tgaaccggtt 2633041 acaatgactt catccggaga ctgggtgccc gaaagccttc caaacacatt gccgacatcg 2633101 tcgaatcttg tttcaagccc gaaagaagac atttccgttt tcacagcaag ctgtgcgtcc 2633161 atccactctt ttgtgtataa aagcctcgtt acgccgccat ccgcagacgc accgtattgg 2633221 gcgagccatt caatataatc tgtgatgctg ttttttactg aaagcttctg cttttccatg 2633281 tactcccccc tctggccgct atggtgactt cattatagaa ggagcaacat gatagttcat 2633341 tgacagatta accaaaaaaa cgtttatttt ttagccacag tatccatcca gcaaccagat 2633401 acaccctaca tgtcacaact attttgatgt aaaggtcaaa agaaaacacg gtaaggaaga 2633461 gagccagcaa gagcgaaaga gagggtcaaa atgcctttca tatgaacaag ctaagctgga 2633521 gaggcgatgt tcgcggaacg gatgaaaaca gaaatgccgg cagcccgcaa aaacaggacc 2633581 taaagatatg gaaacaggag atttccgcct cctccaaagg gactaattta caattttaat 2633641 gaaaaatata caaaatgaca cttctatcct ttatttcaat tttagataat agatatgatc 2633701 tgataaaagg agggcaagtg atgacaaaaa aagcatggtt tctgccgctc gtctgtgtat 2633761 tactgatttc cggatggctt gcgccagcag cttcagcaag cgcgcaaacc acattaagcc 2633821 ttaatgaccg attggcgtct tccccttcag gaacgggaag ccttctctca ttagccgccc 2633881 ccgctgcacc ctatgctgac acagatacct attatgaagg ggctgaaggt aaaacaggag 2633941 actcgctaaa aagcaccctg caccgtatta tcagcggaca cacgatgctg tcctacagcg 2634001 aagtgtggaa cgcgctgaaa gaaacggatg aagacccaag aaatccgaat aacgtcatcc 2634061 tgctctatac gaatgaatcg cgttccaaaa acctgaacgg cggcaatgtc ggcgattgga 2634121 accgcgagca tgtctgggcg aaatcccatg gcgattttgg tacgagcaag ggacctggta 2634181 ctgatattca tcatttgcgc ccggctgatg ttcaagttaa cagcgccaga ggaaatatgg 2634241 attttgacaa tggcggcact gaatatgcga aggcacccgg aaattattat gacggcgatt 2634301 catgggagcc ccgcgatgat gtgaaaggcg atgttgcccg catgctgttt tacatggctg 2634361 tccgttacga gggtgatgac ggctatcctg atcttgagct taatgataag acaggcaacg 2634421 gctcagctcc ttatcatggc aaacaatctg tcctgctcga atggaataag caggatccgg 2634481 ttgacgaccg cgagcggaaa agaaatgaaa tcatttatga aaaatatcag cacaaccgca 2634541 atccatttat cgaccaccct gaatgggcgg atgagatttg gccgtaagaa aaaggtgctc 2634601 cttttgagga gcaccttttt ctaatacaca gcctcttccg tttccgcatc gaaaaagacg 2634661 acgtggtcca ttttcactga gagctggatt gaatcgcctg catcgattcg cgtgtttccg 2634721 tccaggcgga ccttgagccg ctcgtcccca gccatgacat gcactatgag ctccgagccc 2634781 agattttcat tcacttccac gttcgcttga aacactgaat caaacaactg gtcatttcct 2634841 gtcatttgtg tgatgtgctc cggccgtaca ccggcaatca tctgttctcc ggcatatccc 2634901 ttttccttca gccgctttgc tttttcttca ggaatatgaa gccggatcga agaatttgtg 2634961 aaaaacagct cgccatgctg ctgttctatg atgcctttca aaaagttcat tccgggagag 2635021 ccaatgaagc ctgcgacaaa caaattggcc gggtaatgat aaatgtcatg aggtttcgcc 2635081 acttgctgaa tttccccttc attcatgacg acaatccgat ctcccattgt cattgcttcg 2635141 gtctggtcat gcgtgacata aatgatcgtt gcctctaatc gctggtgcag cttgctgatt 2635201 tctgtccgca tcgtcactct tagttttgca tccagattag aaagcggctc gtccattaaa 2635261 aagaccttcg gctccctcac aatcgacctg ccaagcgcca ccctttgccg ctgcccgccg 2635321 gagagcgcct tcggttttct cttcagcaaa tgttcaattt ctaaaattct ggctgccgca 2635381 tgaacccgct cggcaatttc ctgtttcgcc atctttctga gctttaatcc aaacgccata 2635441 ttatcaaaaa ccgtcatatg cggataaagc gcatagttct ggaataccat cgcaatatca 2635501 cgttctttcg gcggaagatc attgacccgc tccccatcaa taagaagatt tccttcagaa 2635561 atgctttcta atccagccac catccgcagc gttgttgatt ttccgcatcc tgacggcccc 2635621 accagcacca aaagctcctt atcctttaca tctaaatcaa agtccttcac ggttaattgt 2635681 gagtgatatg attttttgac gtgttcaaat gttaatgaag ccatcagaaa agtcccccta 2635741 tcttttgacc cgttatttcg tcactggaaa caacttggtc tttctgttat ttttagagta 2635801 atcgattccc atttttgcta tatttctaaa ataaaaaatg taaatttgta ttataacgtc 2635861 ataatacatt ataatataaa taataggtta aaaggaggct accctttgtt aaacaacgga 2635921 agttctacac ctttatacat tcagctaaaa caaatcatca ctgatgacat caaaaagggc 2635981 gtgtattccc caaccgccaa gctgcctacc gaaaacgagc tttgcaccaa gtataacgtc 2636041 agccgcatca ccgtcaggaa agccattctc gatttagtcg aagaaggcta tctgatcagg 2636101 cagcagggaa agggaacgtt cgttaaaagc cctaaattaa aacgagagct gatcgctgta 2636161 aacggctact cggaatttat ggaatcaacc ggcaaaaaac cgaagcatca tgtgctgtcc 2636221 catgacatca ttccagcgtc aaaacccatc gccgaaaagc ttcaaatcca acccgagagc 2636281 cctgtggttg aattaaaacg gattttatat aatgatgatc agcctctcac ctttgaagtg 2636341 acgcattatc cgcttgattt gtttcccggc attgatacct ttattgctga cggcgtctcc 2636401 atgcatgata ttttgaaaca gcaatacaaa gttgtaccca cgcacaatac gaagctatta 2636461 aacgttgtat atgcccaaca ggaggaaagc aaatacctgg attgtgatat cggggatgcg 2636521 ctgtttgaaa ttgataaaac ggcttttaca tcaaacgacc agccaatcta ttgctcattg 2636581 tttttgatgc acacaaaccg tgtcactttt accatcaaca gcccctacac ataacaggca 2636641 taaaaaacga gacactgctt atagtattct cgttttttca ctgcttcccc cgtcctccaa 2636701 gcgataagga tagccatagc cgaaagctcc gtacacaccg caagttttcg cagccgtttc 2636761 agcagcctgg cgcaaagcat acgttatatc ctgcttcacg caaaaggcag tcaaaaagcc 2636821 tgctataaaa gaatctcccg ctccaagtgt atctattata tcagcttcca caatcggctg 2636881 atgatagact cgatcacccg cagacaggat tgctccttgg ccccctcggg tcatacaaac 2636941 cattttggct ccgtacccat gagctgtttt ggcaagctca ccgcattccg actcactcaa 2637001 atcgcttcct gaaaaaaacg catacgtcac ataaggacag accctcctca aataatcatc 2637061 ctcccgattg gttgaaaaat caaatgagac cgggaccagc ccgcacagct gcggaagatc 2637121 gttctcaagc ctgctgtaca cgctcgtatg cagcagatca tgcccgctga taaaagatac 2637181 atctttctcc tgaaacgcga ggcgaagccg ggactgaatg ccgcctttat ttgatctgac 2637241 aaaaatgcgg tccccctgtt catcaagggt gacaatcgcc atcccgtttt ctccgtgcgc 2637301 ctggcggata taatctgcat tgacctgctc cagcttgaga acgttcaaca gatgcgccgc 2637361 ggcttcgtca ttgccgacga ttccgatata ggaagactca tgcccgagcc gcttggcaag 2637421 cacagcaacg tttaaggcat ttcctcccgg gtaaaatgtt tcttgatcct ggtagtaatc 2637481 tacaacatta tctccaaccg caatcaattt catagcgctt cctcctttat ccttttacac 2637541 tgccgcttgc aatcccgcgg acaaaatatt tctgcatcaa taaaaataga ataataatcg 2637601 gcgcggctga aatcgttaac cccgccagca ggacgcccca gtctgtctgc agcgcgtctc 2637661 tgaactgcat cagcccggct ggaatggtcc gtaaattctc atcatctatg aaaataatcg 2637721 caaacataaa ctcattccat gtatggtaag ccgtcaaaat gccggatgtc accaaaatcg 2637781 gcacgctcat tggtaagaaa attctgaaaa atactccaaa acttgtacac ccatccaaat 2637841 aggccgcctc ctccaattct tttgaaatag aaagaaaata agagcggatc aaaatgatgg 2637901 tgaatgggat ccgataagcc gcatacggca agattaacgc ccaatacgta ttgtacaggc 2637961 ccagcgactg aataatagaa taaagcggca caagactgac ctgcggcgtc agcatcaatc 2638021 cgccaagaca tagcaccaaa aagaatcctt ttcctttaaa ctcaaaccgg gaaaggccat 2638081 acgctgccca tgcactgata aagacagtga tcacacacgt cagcgccgta acgatgacac 2638141 tgttcataaa ataagaagaa atcccctgat tccaggcgga aacaaaattt tccggatgcc 2638201 acgaagacgg cagcgaccag ctgtgctcaa aaatatcgtc agagttttta aaggcgctca 2638261 tcaccatcca gagaagcgga taggcaatcg caatcagata aagaaacaga aaaacccaca 2638321 cagacgtttc tccgatatac cattttcgtc taggcttatc tttcacctca atgtgctggt 2638381 caggcaccgg ctccaatctg aacgaatctg tcttcttctg aggcagcatc agttactcct 2638441 cctttccggt tttaaagaac ttcatttgca tgagcgataa tgcaagcgta atgattaaca 2638501 cgacagtggc aatcgctgag gcgtagccca tcatatcctt tgtaaaggcg cttttatata 2638561 aaaacgtgct caagacttct gacgcttttc ccggcccgcc gcctgtcaaa atgtacggct 2638621 cattaaagac cgtaaaggct ccggtcagcg tcatgaccac cgcaacaaaa gacatctctt 2638681 tcgtctgggg aacagtaata tgaaaaaact gctgaatttt acccgcgccg tcaagccggg 2638741 ccgcttcata cagttcatcc ggtatttttt gaatcgacac gatgtacagc atcgcaatat 2638801 aaccgacaga ttgccactgg gacacaaaaa tgacagaaag catagctgtg ctgtcatccc 2638861 cgagccaggc cctcgtcagc tgatcaagac cgatggcctg aagcagctga ttcaaaagcc 2638921 ctgtctccgg attgtaaata aaatcaaaca aaagcgcgat caccgtcatt gagatgacaa 2638981 ccggcaaaaa gaaaacggta cgaaaaaacg gcgaccattt tctgaccagc ttatcctcaa 2639041 gcaccgccgc caaaatcaaa ccgccaaata cctggcatac aattgagatc actgcataaa 2639101 gcacattatt ggtaagtgcc tgatagaaga caggatcatg aaataattca acatagtttt 2639161 ttaagccgat aaacgttttt tccggagaaa atgagctcca ctgaaacagg ctgaggaata 2639221 cattctcaaa aatcgggata taaacgaaaa gtaaaaaaac gagagcgggc accaaaaaca 2639281 aataggggat tattttattc tgattgacca agggtatctc atctccttta taaaaagaaa 2639341 aggtgcgaag cttcaccttt tctttgattt attcagctga cgccctcacc tgctttgctg 2639401 ccttttgaac ggctttcatc acctgctgcg gtgtcatgtc gccgccaagc atttgctgga 2639461 cgcccgttag gtacgcatct gcgacttcaa catcgacatc catatcaaac catggaacca 2639521 ttgatttggc atcaacaata tgctgaacgg cttcacgctg aatggctgtt gcattttctt 2639581 cagtagccgt accttgcact gcactgtatt tcccgacatc tttcacgagc ttttcgccca 2639641 ttcttttcga cgtcaagaac tgcaaaaatt ccatcgcttc cttcggatgt tttgttcttg 2639701 aggagatcat gaatccttcc ggcgctcccg ttaacgcttc tgaagatcct ttctgcccgc 2639761 tgatttcagg aaatgggaac atcccgagat taaccggttc aaccagcttg atttccgctg 2639821 tttccgcata tatcatcgcc gactttccgc tcttaaattg ctgtctcaca tattcgtggt 2639881 cgacggagtt tacatgttta ttaaagtaag gcatcagctc ttgaagcttt tcaagtgctt 2639941 ttacgtagcc ttcatcagta aattcacccg ttttggcgtt atagtccttt tcccgtgttt 2640001 tttcatcgac catccgctga ttaagcgtgc cgatatagtg cgagattgtc caagtcgcct 2640061 ttgttccaaa gctgatcggt gtgtagccat gttctttcag cttttttgac acatcgatta 2640121 attcatccca cgtcttcggg ggatcaagat tcagcttttg gaaaatgtct ttattataga 2640181 agaatgattt agcgtccatt tgccacggta cgccatattg cttgttttca taagtaaatg 2640241 gtgtaatttg cgattgaacg agctgtgatg accaatcggt gtcatttttg tagtaggacg 2640301 agagatcaag tgctttattg cctctgataa atttaaaagc aaactcatcg ctccaagaga 2640361 agtaaatgtc aggagggctg gtggttccca gcatgacctt aattttatct ttataggagt 2640421 catttaaaac ggcttcaatt tgaatgtcga tatctgggtg atctttttca aattccttaa 2640481 caacctcttc aaaataactt ttttccggct cctttggcca tctgtggaaa aatttcaatg 2640541 tcacctttcc gtccgctgaa ctgctttggc tcgaacagcc tgcgatggtg agcatactga 2640601 cagctgcaat gatcaagaac aacaacattt tcttcaaagg gttggcctcc tctggacatt 2640661 agactataat gttatataac attatagtct aatgcataat ggttcttcat tttcagatca 2640721 atactcaact ttccacatgt atcttctatg agataaagga tgatttctct cctctgccag 2640781 ctcgtctgca tagcttctca gcacacgatt gagaacgagc ggagcaagat agcctttaac 2640841 tgaatcgtca attgcagtga agtcgtaaga tgcagcatca agcacagtga gctttttgcc 2640901 atactttttc gagaaggtaa gcgcccgctc ttcaagaggt cttgtttcat ctaaaccgag 2640961 caggatgata aacggcacgg attcatcaat aatttcaaac ggtccgtgaa aatattctcc 2641021 ggcatgaatg gcgtgggaat gaatccattg catttccatg agaatgcaga tgctgtagga 2641081 gtaagcgaca ccgtagtttg caccgcttgc catggtataa ataatgcttt ctttttcatg 2641141 ggcttttgca aattgcttgg cgttgtcagc ttcctgctta agggcttttt catatacagc 2641201 ctgcaattga tctaagcctt caattgcttg ctcaaatttc gtattgtttt ctaatacttg 2641261 cagggttcca aaaacgattt gatacaaaac gccatagttt gtattgatcg caagcgcctc 2641321 atcaccccaa tcgtactggg caacatattg cgcttcctgc gctaaaggag actccggttt 2641381 aaacgtcatc gcaatcgtaa gtgcgccctt gccccttgca aacgcagcag ctttgactgt 2641441 ctccggggta tttcccgaat gcgagcacaa aataacaaga gacttttcac caagctgaac 2641501 agggttgcgc tgaataaatt cgttggcgct gtagagatcg gagtttattg attttgactc 2641561 tctgtcaaac acatacttac tcggatacat aatggcagaa gaccctccgc atgcgacaaa 2641621 gaatacatga tcaatggttt tccctttcaa atcctgcaag aaagcttgaa cctcacgatt 2641681 tacttttgct gtggcctgac tcaaatcctt cactcctcgt ttttattata taacgttata 2641741 taacattata tattgttata ttaaagtccg cgggtaggat tgtcaatatt attttctgaa 2641801 atttctcaat aatttattcg gatgacagac aaagggtcta tatgcgaaaa aatgcccaaa 2641861 tcaaaagcca gaacttgact taagctctgg cttcgctgtt caatccgcag actgacgtct 2641921 tatttaaaaa ataccttgtc tatattgtac ttcgagtgct gtgtattgat gatatatgtt 2641981 tcgtaaatct ctctttccat tggatcatca actacacata cctcaatttt ataaacttca 2642041 tctctgtgat gtttgatcgg tgaaacagtg tcttcgaaat gcttcttaat tctctgtctt 2642101 aactttctgg ctttaccgac aaacagcagc tcgtcatgaa tgttgtaaaa cataaaaatg 2642161 ccgcctttgt cccttgggat ctggtgaaag tcgatgaatc cgtgaatcgg ttttatcttc 2642221 ggctcgttat cattagctga ctgctgtcgt tcagtgatgg tgacattcgg tgcgggtata 2642281 tcaattttta tcaaaatcag ttcacgtcct ctttttcatt aaagataaat gctaacacat 2642341 acagaaaaga aaagctagaa cagctttatt atatttgttt gtcatgctct tacttattat 2642401 gcaagtgctc cggctggatc ataaggacta aggtctaatt ctgtctgctt tccgagaact 2642461 agctttgcga gctctgcacc caaaaacggc cccatcgtca gtccagaagc acccaaaccg 2642521 tttgcagcgt acaggccttg aacattcggc acggccccta cgaccggcag aaatcccggt 2642581 gtaaacggcc tgaagcccac tcttgtttca acagcagccg catcagcaag acccggtgca 2642641 acggctaacg ctttgctcaa tacttcgtgc tggcctccgg ctgtcacacg aagatcatca 2642701 agaccggcat cgttttcgtg tgtggcgccg gctacaattc tgccgttatc aaacgacaga 2642761 atgtactgat cactcggcgg cattacaacc ggccacgatc ctgtatctgc atctgtcatt 2642821 tcaaaatgca taatctgcgc tttttgaaat gacacttgaa aatgaatgcc aagaggcttc 2642881 aatatctcat tggcccatgc tcccgccgtc acaatgaccg cgtcagccgc aaactgcttt 2642941 gtatctgttt gcacgccggt gactgttccg ttttcaaaaa gcaaggacgc atttcctttg 2643001 atgaccgttg cgccgcgttt ctctgcagcg cttaaaagcg accggcacag cgctcttccg 2643061 ttcacacggg cggcaccgct gatatgaacc gattcatagc cgtcagctaa aatcggaaac 2643121 agctttttcg tttcacttgc agacaagcgg gtaatgtcgc cgatttccgg cgcatcctcc 2643181 cgtctcttat acgccctttc ctccatttta tcgagtttag acgcgtcagt atgaatgctg 2643241 atggcaccga cacgtttgta tcctgtatcc gattcaccgt ctttttccaa ttgatggatt 2643301 aaatccttat agtaccgcgc tcccccctta gcaagctggt accaatcctg attacggcgc 2643361 tgcgagagcc aaggacagac gatccccgcc gccgcatcag tcgcttgtcc cggctctttc 2643421 cgatcaatga cagtaacgcg agcgcctgtt tttgcgagat gataagccgt cgacgcgccc 2643481 agaatccctg cgccgacgat gatgtacgat ttcatatgca aacacctttt ctattataat 2643541 gtctattcat tttaccaaat caaatgcttt ccttcgacct tttgccctaa tgtggaaaaa 2643601 ccgcgaagtt cgtccaatct ctttactctc ctatcgaata tcctgtcact atcaatagag 2643661 aaaggatgat accatgagcg aaaatcgtca tgaaaatgaa gaaaacagac gcgatgcggc 2643721 agtggcaaaa gtccaaaaca gcggtaatgc aaaagtcgtg gtcagcgtga acacagatca 2643781 ggatcaggca caggcgcagt cacaagacgg agaagactaa tgaacgaaaa catcattcct 2643841 cttaacagac atactcaaga gatacccact actgaatctg ttatcaaaaa cagcggcaac 2643901 tcagaggtcc atatcgacat tcacattgat acaatgccaa ttgcttttgc tatattatgc 2643961 tctgcattag ccgcaaagca gatgacaaaa gaggaattcg atatggctta tactcaattg 2644021 cgagagatga acagagaaaa taacagcaga tcatctgtaa agcaaattat caatcaagag 2644081 acagaagaag agtaaaaaac cgcggcccct cggccagcgg tttttcttct gcatacaaaa 2644141 aggacgcgac tgaatcggtt acttctgtac aatttgaata aggttaccgc atgtatcgtc 2644201 gaagacagct attgtgactt cgcccatttt tgtcggttcc gtcgtaaacg tcacgccttt 2644261 ttcctttaat cggttgtact ctttttgaat atctgcaacg ccaaacattg tggccgggag 2644321 gccttcggag aatatcttct tttgatactc cttggcggca ggatgttcat tcggttcgag 2644381 taaaagctcg gttccgtctt gatcatctgg agaaacaagc gttatccacc tgaatttccc 2644441 catgggaacg tcttcctttt ttataaaccc aagtttttct gtataaaact ccagtgccat 2644501 gtcttgatct tgtacaaata tactggtaac aacgattttc atactgtttt tccctccttc 2644561 gatatgaatg aagcatggta ctatgctaac aatctggcta caagcaaaac aacccacaca 2644621 tttatcagag gccctgttct gattttataa aattattcta tccatccttt cagcaaattt 2644681 ttaagcggtt cgttgttgaa tataagtact cgatattttc cctttcgttt tgatgttacg 2644741 agtcctgcat cctccagtac agaaaggtgt ttagctatcg cctgtcgcgt aatagaaagg 2644801 tcgtactttg taataagacg tatcgtaagt tcatacaacg tcagctcgtt gcgttcagat 2644861 aattcgtcta atataagccg ccgagtcgaa tcgccgagtg ctttgaatat agcgtctttg 2644921 ttcccattca tatattgagt ataagcaacc cattagttgc atgtcaagta taagcaactg 2644981 tatggttgcg tgatatagaa actgaaccta tccggcgcag gtctgaaata ttctaatcga 2645041 taaggaatta aaaccattaa aataacagtg gatatgtctc tgaaaaataa aagaagacga 2645101 acttcaaaag ttcgtcttct acaatcaaat tcggcacgcc ggccatttta aagttgataa 2645161 ctatctctaa accccttgat aaacaaagga gttttcatca ttaaccgata gaaccttcca 2645221 tttcgaactt aatcaaacgg ttcatttcaa ctgcgtattc catcggaagc tcttttgtga 2645281 atggctcgat aaagcccatt acgatcattt cagttgcttc ttcttcagaa ataccgcggc 2645341 tcatcaagta gaagagctgc tcttcagata ctttagacac tttcgcttcg tgctccaatg 2645401 aaatgttatc atttaagatt tcattgtaag gaattgtgtc agaagttgat ttgttatcca 2645461 taatgagcgt atcacactcg atgttagagc gggcgccttc cgctttgcgt ccgaagtgga 2645521 cgattccgcg gtacgttact tttccgccct gttttgaaat cgattttgat acgattgtag 2645581 atgatgtgtt tggtgcaagg tgaatcattt tcgcacctgc atcctgatgc tggcctttac 2645641 ccgcaagagc gatagaaagc gtcataccgc gcgcgccttc gccttttagg atacaagccg 2645701 gatatttcat tgtcagctta gaaccgatgt tgccgtcgat ccattccatt gttgcgtttt 2645761 cttcacagac tgtacgcttt gttacaaggt tgtaaacgtt gttcgcccag ttttggatcg 2645821 ttgtataacg gcagtagccg ccttttttca cgatgatctc aacgaccgca ctgtgaagtg 2645881 agtttgttgt gtaaacaggc gcagtacagc cttcaacata atgaacgctt gcttcttcgt 2645941 caacaatgat cagtgtacgt tcgaactgac ccatgttctc agagttgata cggaagtaag 2646001 cttgtagcgg tgtttcaacc ttcacgcctt taggcacgta gatgaaagaa ccgccggacc 2646061 aaacagctga gttaagcgcc gcaaacttgt tatcagtcgg cgggattact tttgcccagt 2646121 gctcacggaa aatatcttca ttctctttca gcgcgctgtc agtgtcttta aagacgatgc 2646181 cttgtgcttc aagatcttct ttcatgttgt ggtatacaac ctcagattcg tactgagcag 2646241 aaacacccgc aaggtatttt tgttcagctt caggaatacc gagcttgtcg aatgtttgtt 2646301 taatttcttc aggaacttca tcccaagaac gctctgaacg ctcagacggt tttacgtagt 2646361 acgtaatttc gtcaaagttc agtgagttta aatctccgcc ccattgaggc atcggcatat 2646421 tgtagaaatg ctcaagtgat ttcaagcgga agtcaagcat ccattgaggc tcttctttca 2646481 tgcgagaaat ttcttctacg atttcttttg tcaatccgcg ctctgaacgg aaaatggaaa 2646541 cgtccttgtc gtgaaaacca tacttgtatt caccaatatc aggcattttt ttagccatcc 2646601 attttcactc caatcctttt aattgccgcc ttcttctttc gcgactcctt tttcaagtgc 2646661 tttccatgac agggttgcac atttgatacg ggcagggaat tttgaaacgc cttgaagggc 2646721 ttcaatatcc ccgagatcta tagaatcatc atactctttc ccttgcatca tatccgagaa 2646781 aatcttagac atggaaaggg cagtttcaat atctttccct ttaatcgcct gagtcatcat 2646841 cgaagcggat gccattgaaa tggaacagcc ttccccttca aacttcgcat cttccacgat 2646901 gtctccgtca agcttcattg tcagtctgat gcggtcgccg catgtcggat tgttcatatc 2646961 cacgacaatg ctgtcattta aaaccccttt atttcgcggg tttttgtaat gatccataat 2647021 cacctgtctg tacaatgtat ctaagtttgc attaaaagac atttgtaaaa tactcctttg 2647081 tcttttgaag agcttccaca agcttatcaa tctcttcctc tgtattatac agataaaagc 2647141 ttgctcttgc agtagcagtt acatccagcc atttcatcag cggctgcgca caatggtggc 2647201 cggctctgac tgcgattccc tccgcatcaa gcacagtcgc cacatcgtgc ggatgaacat 2647261 catcaaggtt aaatgtgaca agcccggcac gctcttccgg cccgtaaacc gttacgccgt 2647321 caagctggcg gaagcgttca agcgcataag ctgcaagctt gtgctcatgg cgggaaatct 2647381 catcaagacc gatttcttcg agaaaatcaa tggcggcacc gaggccgatt gctcctgcaa 2647441 taatcggcgt acccgcttcg aatttccacg gaagctcttt ccaagttgat tcataaagcc 2647501 cgacaaagtc gatcatttca ccgccgaatt cggcaggctc catgttttcc agcagggctt 2647561 tctttccgta cagcacacca acaccggtag gtccgcacat tttatgggaa gaaagcgcaa 2647621 agaagtcgca atcgagatcc tgcacgtcaa ttttcatgtg aggcgtgctt tgtgcaccgt 2647681 ccaccacaat gacagcccca ttgtcatgag cgattttcgc catttcttta atcgggttga 2647741 ccgtgccgag aacattagat acatgagaca ccgcaacaat ttttgtgttg cttgtgaccg 2647801 tttctctgac gtcttctaaa gaaatcgttc cgtcttcctg caacggaata tattttaatg 2647861 tggcgccagt tgcttttaca gcctgctgcc acggaatgat attcgcatga tgctccatgt 2647921 aggtgatgac cacttcatca ccaggtttca ggttggcgcg cgcatagctt aacgccacca 2647981 tattcagtga tgtggtcgtg ccttttgtga aaataatctc agccattgac ttcgcgttaa 2648041 taaacttgcg gactttttca cgcgctcctt cataaccatc tgtcgctctg gttccaagtg 2648101 tatggacgcc ccggtgaaca ttggaattgt attggttata atacttatcc agtgtttcaa 2648161 tgacagcacg cggcttctgg gaagtcgccg cgctgtcgag ataaacgaga tcatgtccgt 2648221 tcacttgctg atgaaggatc gggaactgtt cacgaatatc tgtgatattc attacttcac 2648281 tttcctttcg ataacagaaa ctaattgttt cttaacgcct tcaatcggaa gttcatttac 2648341 taccggtgca aggaatccgt aaatgactaa gcgttctgct tcttctttcg gaattccgcg 2648401 gctcatcagg tagtaaagct gaatagggtc cacacggccg acagatgccg catgtcctgc 2648461 agttacatcg tcttcgtcaa ttaaaagaat agggtttgcg tctccgcgtg ctttttcgct 2648521 aagcatcagc acgcgtgatt cttgctccgc attcgcttta gaagcgccat gttcgatttt 2648581 gccgattccg ttaaagatag aagaagcgga atccttcatc acaccgtgct tcaagatata 2648641 gccttcagaa gctttaccga aatggatgat ttgtgttgtg aagttttctg tttgctctcc 2648701 tcttccgaca acaaccgttt tcgtatcgcc gtatgtgccg tcaccgtaaa ggtttgttgt 2648761 gttttcggaa atcgtgtcgc catcgttcat caggccgaga gcccactcga ttttgctgtc 2648821 gcgtccgcgc gcagcaccgc ggcggttcac ataagttgtc acaccgcttg acagattatc 2648881 caccgcaccg tatgtcacgc tggcattatc acctgtgatg acctcactga taatattgaa 2648941 gacagcgtct ttcgggttta cagtgctgat gtagttttct acatatgtta cagagctgtg 2649001 gtcttcagcc acaatcagca cgtggttgaa tagagctgta tcattgcttt cgtggacata 2649061 aacagcctga accggcgtct ccacctgaac atttttcgga acataaagga atgctcctcc 2649121 gttaacaaga gccgcgtgaa gtgcagttaa cttatgttcg tcaaccttca cgccgtcctt 2649181 cataaagtat ttctccacca agtcgctgtg ctcgcgtgca gcagtcagaa tatcagtgaa 2649241 gatgacgcct ttgtctttca attcttgaga aagagaaaga tgtgccggcg tctggtcacg 2649301 ctgtacgtat aatgttttat cttcgttttc aatgtcgatc agcgctttta cttcatcagt 2649361 caaatcttct aatgaagaaa gcggttcgtt atccactgta tgcttcgcga aattcgtgaa 2649421 gttccagttt gtgatttttg ttttgtcagg tttcggcatc ggcagatcct cagcttgttc 2649481 aagagcctgt aagcgcaggt tcttcagcca ggcaggttct tggtgctttt cggaaaagct 2649541 tttgagatac tcctgatcta cggatagttt tgtacctagt gtcatattaa tccccctaac 2649601 gcttacgctt cttggccaac agtttcgtct tcaatgccaa gttcttgttt gatccagtca 2649661 taaccttctg cttcaagacg ctgtgcaagc tctgcaccgc cggattttac aacgcggcct 2649721 tgcatcataa cgtgaacaac atccggagtg atgtagttta acaggcgctg atagtgagtg 2649781 atcatcaggc agccgaagtt ttcgctgcgc attttgttga tcccttttga tacaactttc 2649841 aaagcgtcaa tatcaaggcc tgagtcaatt tcatcaagga tggcgatttt cggttcaatc 2649901 atcattaatt gaaggatttc gttgcgtttt ttctccccgc ctgagaagcc ttcgttaaga 2649961 tagcgctgag ccatttcagg gtccatttca aggaactcca tgttttcgtc cattttgcgg 2650021 atgaatttca tgagagaaat ttcatcgcct tcttctctgc gcgcgttgat tgctgagcga 2650081 aggaagtcgg catttgtcac accgctgatt tcacttgggt actgcattgc aaggaataag 2650141 cctgcctgcg cacgctcgtc cacttccatc tccagtacat ctttgccgtc aagcgtgatg 2650201 ctgccttttg ttacttcata tttaggatgc cccataatag cagctgataa agtggattta 2650261 ccagttccgt tcgggcccat tactgcgtgg aattctccac cttttatttc aaggtttaca 2650321 ccctttaaga tctctttccc ttcgatttca acgtgaagat ctttgatcgt taatgttgaa 2650381 gcagccatat ctatacctcc aaaaatatat aatcattatt ctcattttat tctcattcta 2650441 attttataac aaatgaaaag taaatacaac tttttatcgt gccttgcaca ttcctcaagt 2650501 ttaacaaaga tcagcacttt attaaagcga ttgaaaaaga aaaagagtgg attcccaccc 2650561 ttttttaaaa gattgatttt ctcaataagc tcccgcagaa atccgcttgc ttttttcata 2650621 atcaagctct ctctgccgct ctactttcat tcttgtttcc agccggcgtc catattcctc 2650681 gtatccaatt ccgtgtgaca gctgcatcgc tttttccatt tctgacgtat aatcgaggtt 2650741 cagtctgtcc tggctgctgc aaataatgaa tcaatccctt catatatttg ctttttattg 2650801 taccagtgct gcgttggatg ccgcaaaaac gatttggcgt gaaatagcgg cagatgagac 2650861 gaaagcatcc tttcagaaca aatgagaatg gtttttcgga atattccttc tcttaatgcg 2650921 tggtgtttcc gaattcctca atgcactgtt gaacgactgt cacgccttgg ctgaaagctg 2650981 cgccgcctcc aaatgccgct gccacactga cggcttcgag aatgttttct tctgacgctc 2651041 cctgatcaag acagcctttt gtatgataga tcatgcaata ttcgtcctga gcattgatgg 2651101 caattccgag ggcgatcagc tgtttttctc tttcagtcag agaattcccg gcaaagcact 2651161 gttcagtaaa ttcgttaaat tttcttccca tcagcggcat cttttgttca aatgtgccta 2651221 aaccatgttt atattgtttt aacgcgtcct gcatgcttcc tctgtcttga ttcaaagaaa 2651281 atccctccat ctgtttaaca ttccttttta ttatgaacag cttttaggaa aatacgcgaa 2651341 aaaaaccccg gaattctcat ccggggtttc agtcttattc agatacagga agcacagctc 2651401 cgtcgtattt tttctcgatg aagtctttga tctttttaga gtgaagaact tccatcagcg 2651461 ctttgatttt tgcagaatct tcttcgcctt ttcttactgc gatgatgtta gcgtatgggt 2651521 tgtttttcgt tgattctact tcaattgcgt cttttttagg atttaattta ttttggatcg 2651581 catagtttac attgatgaag accgcgtctc cttctttgtt ttcatatgct tttgccgtta 2651641 attcaggcgc tacttttttg aattcaaggt ttttcgggtt tttcttaatg tctttcaatg 2651701 ttgcgtcaac tgtttccact ttagaatcaa gagtgattaa tccagcgttt tcaagcattg 2651761 caagcatacg gccttgttca gcaacgttgt ttgtcagaat gattgtcgca ccgtctggaa 2651821 ggtctttcag tgatttgtat gttttagagt aaataccgaa tggctctaag tgaacagcgc 2651881 cggcattcac aagtttgtaa tctgtgtttt ctttcatttc ttgctcaagg taaggaatgt 2651941 gctggaagta gttcgcgtcc acttctttat cagctaaagc tttattgtac attttgtaat 2652001 cactaagcac tttcactttc agcgtatagc ctttttcttt cagcaatggt tcagcttctt 2652061 ttaaaatttc cgcatgcggt gtttttgttg ccgcaacgac aatttctttc ttgccggatt 2652121 cagcgccgtt attcgaaccg caggcagcca taactcctgc aaatacaagc agtaatgcac 2652181 ccaaaaatag ctttttcaat gtaaatcctc ccttatcgtt tgtctataat atttgttatt 2652241 agatcaccga tgatttgaat aataaacacg atgattaaaa taaacacagt agcaacgaag 2652301 gtaacatcag cgttattaga ctgatatcct tctacgtacg caaggtttcc aaggcctcct 2652361 gaaccaatgg ctccggcaat tgccgttgaa ccgattaaag cgatggctgt aaccgtaatg 2652421 ccagaaataa gagcaggcat tgattccgga atcagcactt tgaaaataat cgtagacgtt 2652481 ttcgcgccca ttgatttagc tgcttcaatc acacctttat ccacctcacg cagcgcgatt 2652541 tcaacaaggc gcgcgtaaaa tggtgccgag ccgattacca gcgccggcaa tgcggcgttt 2652601 ggccctaaga tcgtgccgac taaaaatttc gtaaaaccta atagtaaaat aattaaaata 2652661 aggaacggaa tcgatctgaa tatgttaaca acggctgcaa tcactgagtt gaccgcttta 2652721 ttctgccaga ggcttccttt gctcgtcaga aagagcagca agccgaggat gaccccgatg 2652781 acaaaagcaa acagtaaaga aatcagcgtc atataaagtg tttcatatgt cgcgttccat 2652841 aattcagtta aatcaacgtt cgggaagtat ttttcaaaca ttcgtgatca cctctgcttt 2652901 cacctgtttg tcattaatga atcggatcac gttttgcact tcttcctcgt ccccgtcaat 2652961 gtggatgaac agtgaaccgt aagccccatc cttcgtctgc gaaattttcc cttgcagaat 2653021 attgacgctg acattgaagt ttctgatcat ctctgtaatc agaggctgtt cagctgactc 2653081 accgacaaat gtgagctgaa ccatttttcc tgatgctgta tcatcaagaa ggtgctgaag 2653141 cgtctctttc gtttcttccg gctctgtcac ctgttgaaca aatcgttttg tcatttgttc 2653201 ctttggattt ttgaagacat cgagaacctc gccttcttcg accaccttgc cgttttccat 2653261 gacggcgact ctgttgcaga ttttgcgtat gacatgcatt tcgtgcgtaa tcagcacaat 2653321 cgtcaaaccg agtctttcat taatatcgga caatagatcc agaattgaat ctgtcgtttg 2653381 cggatctaat gctgatgtcg cttcgtcaca aagaagaacc ttcggattgt ttgcaagcgc 2653441 tctggcaatt ccgacacgct gcttctgacc gccgctcagc tgggacggat aagatttttc 2653501 ttttccttct aaacctacca gtttaatcag ttcattggcg cgcttgatcc gctcgctctt 2653561 tttcaccccg gcaatttcta aaggaaacat gatattatct ctgacagtcc gcgaccaaag 2653621 caaattgaaa tgctggaaaa tcatactgat ctcatggcgt gcttttctta aaccgcgtcc 2653681 atttacttca ttaatcttgg ttcccgccac ttccacggtt cctgaggttg gtttctcaag 2653741 gccgttcagc agacggatta aggaactctt accagctccg ctatatccta taattccaaa 2653801 aatctcacct tttttaatgg aaagcgagac gttttggaca gcattgacat ctccatgttt 2653861 cgacttgtaa acttttgaaa catcctgaag attgatcaaa gcaatcacct gccttaacac 2653921 tattctaaga aatcttccgg ttttttctgc aaaagaaaag cctttctgca cacttgagca 2653981 gaaaggctta tataaaatgc ctttctctca tctttcaaag ctgaacgctt cgtgtgaatt 2654041 ggcaccattt caacagtgtt gatggttgcc gggcttcata gggcacttcc ctccacctct 2654101 cttgataaga gaaatatata gtctttttcg tccggaaatt cttaatgtag aatagcacgg 2654161 cgaatgatta aatgtcaata aaataaatga tgtcaacttt tactattata ataatttatt 2654221 attttttaat tttttaaaat cctctgaaaa aatccatttg tcagccagag aatggcttcc 2654281 agctttaaca gggccctgaa tgaccccttt actttgaggc ttccgctctg aataaggtgc 2654341 tgaagggaaa tgtctccgtg caataaatca ataatttccg tttggtttcc gtaaaaggtc 2654401 aggttggacg tttggggcgg agaaactttt ttcatttctc cctgttcgtt tattgagacg 2654461 gttaaggctt ctgcttctcc ttggaaggta atgagcaatg ttgaggcatt caaaaggggt 2654521 tttaaaaaca gatgctgata ctcatcttct aaaacttccg ctttctccat atgtacaacc 2654581 tcctatttgt tggtcataca tacacatttc tctctttgtc gcaagaaccc ctttataaaa 2654641 cgaacgacaa tttcattgga tatgctgaga aatatgtcat aaatgggatg cggaagatga 2654701 tttttgtttg atcagctcat ataaataaga aacggaatga aatgcatatc ctctttcgac 2654761 catctttccg cctttaaaca gcagaaaaca agggacgctt tcaatttgat acgcttttgc 2654821 gaatgtcgga gagtaattga cattgttttg atagaaggcg acatccggca gcatttcttt 2654881 caccactgtc agcattttgc ttgcaagctg gcaggtgccg caaaacggag tatataaata 2654941 tagaaggtac acatcatctt caatgtgatc aagttcgtgt tcttggagtt ctttcatgct 2655001 atacacctcg ggactttctt tcaagaaaaa tagtatggac attcagattc gcacgcagca 2655061 atacagaagc gatatggtgc ctgggcgcag ccgctacttc cttataggct ctgtcgacat 2655121 ggagatggca ggcttcatta aattcacgct tcagctgttt tctcaatttc tcacctgatt 2655181 catcagcatc aactaatata tagacgtctt tatcataaag ctcgtcagcc aattcctcga 2655241 gcctcagctg gctgattgtt ccgtttgtgc agataatgcg catcggttca ttcaggacgc 2655301 tttcgatttt ctctttatct gatttcccct cgacaatcat aaccttttcc agctcatcca 2655361 tcttcatctt gttcacctgc cgcgtcaaat ttgaaatgtt cagattgtaa aagaaggcag 2655421 tgaaattcac cgccaacatt aacaccagcc gttttcgtag tcacaatcta catattttgc 2655481 gtcgtctcca gagaccacat cggctgtctt ataaaatttc tcattttcaa aggaataacc 2655541 ggacttaagc tcatattcat tcatgcttgt catttggccg atcatctcat tatcatgata 2655601 taacgagagc cggccatttt gaaagcggcc tgtcacgtca ttggtgacat cgagcttttg 2655661 tttgtcgaaa gccatattgg acacctccca taacgttagc gtgtccaatt gcttttacgg 2655721 ctatcctgtt ttagtcttct tgtgtcatct cttcgtattg ctctgctgtc atcagttttt 2655781 caatttcaga agcgtcagat ggctcaacga cgatcatcca tgctttttcg tacggagatt 2655841 cgttgacgaa ttccggactg tcatcaagat cttcgtttac ttccacaacc gttccgttaa 2655901 tcggtgcata aagctcagat accgttttaa cggattcaac actgccgaat ggctcgtccg 2655961 ctttgatttc agcgcccact tcaggaagtt cgacaaacac gatgtcgcct agttcggact 2656021 gggcaaaatg cgtaattccg attctggctt tttctccttc aacttttacc cactcgtgtt 2656081 ctcctgagta acgcaaatct tttggtatgc tcaattgaat ccctccattt tttacagcac 2656141 tacaataaga agataccaca cttttcaaaa aaaatttaca ttaagcccag ttttcttcaa 2656201 attggtcttc tttaaatccg acagtcactt tttcgccgtc tgttgtaagc gggcgtttaa 2656261 ttagcatacc atctgaagcc agcagttcga gctgttcgtc ctctgacata tgatacagct 2656321 tttccttgag attgagctcg cggtatttca tgccgctcgt gttgaaaaat ttcttgagat 2656381 ccagcccgct tttttcataa agcgctttta attcttcttt gcttggcggc tgctcagcaa 2656441 tatgtatttc gtttatttct ttcccatgct cttcaagcca cttctttgct ttgcggcacg 2656501 ttccgcattt agggtaccag taaaaagtta acgacatctt cttccccctc aataaaataa 2656561 tcgaggttat tttaacacag tttgttttaa aaacctaaaa cagtgcttct taaaaaagag 2656621 ctccgcgcat gcggagctca tggccaatca gacagtatat ttctcagcct caaaaatgcc 2656681 tgccgccgcc tcgcgttttt tctgaatcac gtttttaggc gttacgcgtg tcagcttgcg 2656741 cagagcggaa agcatcatgc ggagtgaatc tccttcttcc attgcgataa gggattcctt 2656801 tgcatgcgct tcgatttcgt taaaggcctc ttgaacgaaa atttctgtgt acagcacctt 2656861 ttgcgctgct ttttcagcgc cttgtgcggc aatggccttt tccgttctga gcacggctga 2656921 ttccattgcg tatacattgc tgacgatatc cgctacgttc acgagaattt cttgctcacg 2656981 atcgatcgct tttccgtatt tttgcgcggc taggccggca gcaaacaacg caattttttt 2657041 ggcttgcttg acgatatatt tctcctgctc taagacgccg cttccaggct cttcaggcat 2657101 aagcatcatg agttcttcct gcagcgactg cgctttttcg aataaaggca gctcgccttt 2657161 aagcgctttt ttcaggaagg tgcttggcac gattaaccgg ttgatttcgt ttgtgccttc 2657221 aaaaatccga ttgatccttg aatccctata ggccctttct acttcgtatt cctgcataaa 2657281 gccgtagcct ccatgaatct gcacgccttc atcaacgata taatcaagcg tttcagagcc 2657341 gaatacctta ttcagagagc attcgatggc gtattccgca atcgatttgg cgatttgccg 2657401 gccgtccttg agatcttcgg ccgtgaactg gctcatattg tcttcaaaca gcccgacggt 2657461 tctgtataca gagctttcca tcgcatacag ccttgaggcc attgtcccga ttttttcctg 2657521 tgtcaatgaa aaaccagcaa tcggcgtttt aaattggcgg cgctgatttg cgtatgccgc 2657581 agacagctcg atgacgcgtt tagatgcgcc gattgtgcca accgccagtt tgtaacggcc 2657641 gatgtttaaa atattaaagg cgatgacatg ccctttgccg atttctccga gcaggttttc 2657701 ctttggcact tcagcttgat ccagaatgag ggttcttgtc gatgatccct tgattcccat 2657761 tttcttttct tccggtcccg tggagacacc cgggaactct ttttctacaa taaaggctga 2657821 aaacttgtcg ccgtctacct tagcgtaaac tacaaataca tcggcaaaag cagagttggt 2657881 aatccactgt ttttcccctg ttaatacata atgggttcct gcttcattca gcacagctgt 2657941 tgtttttgct ccaagtgcat cagacccaga gccaggctca gtcagagcat aagcggcgat 2658001 cttttcgcct gaagcgagtc caggcaaata ttttttcttt tgttcttctg acccgaaaaa 2658061 gacgatcggc aaggaaccga taccgacatg cgcgccataa gaaagagaaa agcttcccgc 2658121 acgcgaaaat ttctcagtga tgagtgccga gctgatttta tcaaggccga gcccgccgta 2658181 ttcttccggc acatcggcgc caagcagccc tagttcgccc gctttcttca acagtctgac 2658241 agaatgctcg aattgatggt tttcgatatc atctatatga gggagaacat cttgctcgat 2658301 gtaatcctct gttgttttcg caatcatttt atgctcgtca gtgaaatcct ccggtgtata 2658361 catttgatcg tatgtgacat cctcgattaa aaatccgccg cctttttgta cgtcagccgc 2658421 tttttttgcc atttgttttt ccccctttag cataattcaa atacaccggc cgctcccatt 2658481 ccgccgccga tacacatggt cacgactcca aattgctcgt ttctccgttt catttcatgg 2658541 atgagtgaga gtgtaagctt tgtgcccgta cagccaagcg ggtgtccaag cgcgattgcg 2658601 cccccgttga cattcacttt ttcttcatca attcccaatt ccctgattac ttgaatggcc 2658661 tgtgaggcaa aagcttcatt cagttcaaac aagccgatgt cctgcagctg aagtccggca 2658721 agcttcaaag cgcgcggaat cgcttccacc ggtccgattc ccatcacttc cggcggcacg 2658781 ccgcctaccg caaaggagcg gaatttcaca agcggcgcca ggccaagagc atcggctttt 2658841 tcccggtcca tcagcatgac agccgccgct ccgtcactcg tttgtgagga attgcccgca 2658901 gtcaccgtcc cgtcaacgga aaaggccggg cgcaatgtcg ataagatgtc tgcagtcgtt 2658961 tgcgggcgaa caccttcatc ctgagaaaac acaaactgtt tttccatagg cttatggtct 2659021 tctccgattt ctgtcaccgt cacttcgacg ggtacaattt catctttaaa ttttccttct 2659081 gcaagggctt tagcggcgtt ttgatggctg cgaacggcaa acgcgtcttg atcctcacgg 2659141 gagacgccgt attttttcgc gacttgctcg gctgtgtgcc ccatgctcat ataatattcc 2659201 ggtgcctttt ctgccaaagc aaggttcgga cgggtaacat gccccatcat cggaacttgc 2659261 gacatggatt ctgctccgcc ggcgatcgct gtatcgtagg cgcccagcat aattttttct 2659321 gctgcatacg caatagactg aaggcctgaa gagcaatagc ggttaactgt aatcgccgga 2659381 accgtgtacg gcaggcccgc gagcgcaccg atatttctcg ccatattaag cccctgctcc 2659441 gcttcaggtg ttgcacagcc gataatcaag tcatcaatat tgccttcgta gccgcctgcc 2659501 cgtttcagcg tttcttttac acaaatcgct cccaaatcat ccgggcgaac ggtggccaac 2659561 gatccttttt ttgcttttcc aaccggtgtt cttgcacctg acacaatgac tgcctctttc 2659621 ataagctccc tcctaattcc gtaaaggttt acctttcaca agcatatgct gcattctcgc 2659681 ttgagatttt gcctctcctg acaaactcaa aaacgcttct ctttcgatct ccaataaata 2659741 ctcttcatca acctctgtac caaacggcac ttttccgccc gcaatgacat aagcgagttt 2659801 tttcgcgatc ttaaaatcat gctcagatat atagccggac agcttcatct gctcagcgcc 2659861 aagcaagagt gccgcataac cggtttctcc cggcaccttg accttttctt ttacaggcgg 2659921 ccgccagccg gtatcgtata aagatgcggc cagctgcttc gcatcgtata acaggtggtc 2659981 ttgattcacg ctgatctgat ccgtttcttt taagatgttc atctcacgag cctcttgagc 2660041 ggaagcggac actttcgcca tcgcgattgt ttcaaatgtt ttcattgccg cattcatcgg 2660101 atcatggccg cggcgaagat ggttgatgta cagctctttg ttacctcctc cgccagggat 2660161 gaggccgaca ccggattcca caagtcccat ataggcttcg cttgccgctt gaatgcgcgc 2660221 cgccggcagg catgcttccg ttcctccgcc gagcgtcatg ccaaatggcg cggcgacgac 2660281 cggtttcgca ctgtatttga tcttcatcat cgtctcctga aaacggcgga tcacaaaatc 2660341 aacttccaaa aagttgtcat cttggacttc cattaagatc atggcgagat tcgcgccgac 2660401 gcagaaattt ttcccttgat tgccgatgac aagccccttg taattccgtt ctgtttcctc 2660461 taatcctttg tggatcattt gaatgatatc gaggccgatc gcattgcttt tcgaatgaaa 2660521 ttcaagaagg gccacatcat ctccaaggtc aattaagctt gctccgctgt ttttcgcaat 2660581 cacgcctttt gtttctttaa gtgcttgtaa atgaattcgt tttttgtttt ctttcacggc 2660641 tctgtattcg ccgcggtcat aataaaatac cgttccgttc tctttgatgt agaaggtttc 2660701 atttcctttg tccagcatct cttttatcca gccaggcata tctgctccaa gctgctcaag 2660761 cttttccgct gactgcttga ggccgatggc gtcccacatc tcaaaaggtc ccagttccca 2660821 gccgaatccc cacttcatgg cttggtcaat cgcatgaata tcatcggcaa tctcgccaag 2660881 cagctcggct gagtaaagca gggtttgaga agtgatattc cacagcaaac ggccggccct 2660941 gtcatccgaa taaataagcg ctttcatttt ggcttttgtc ccttttgcct gttttgccgc 2661001 ttcaagtgcc ggtgatttca tttttgtccg ctcgccgtaa gtaagcgtca ctgggtcaag 2661061 ctcataaatc gtttttcctt cttttttata aaagccttgg ccggccttgc ttccgatcca 2661121 ccctttttcc agcatatcgt tcatgaagct tggaatgcga aacacttctt tttcatcgcc 2661181 atcagctttg tcatacacat ttcgggcaac gtgggcgaat gtatcgaggc cgaccacatc 2661241 aagcgttcta aaggtggcgc ttttcggcct gccgatcagc ggtcctgtga tcgaatcaac 2661301 ctccccgacc tgataaccgc ctttcagcat ttcttggact gtcacgagaa gcccgtaagt 2661361 cccgatgcgg tttgcgataa agttcggtgt gtcctttgct gtaacaacgc ctttcccgag 2661421 gacattttct ccgaaagctg tcataaactt taaaatatca ggatccgttt ccttaatcgg 2661481 aatgatctct agcagcttta aatatcgtgc gggattaaaa aaatgcgttc caagaaaatg 2661541 ggctttaaaa tcatccgacc ggccttcagc catttcctgc actgatatgc cggatgtgtt 2661601 gcttgagacg atgcttccag tctttcgatg ttcatccaca agagcgaaaa ttttcttttt 2661661 gacttcaagg ttttcgacaa cgacctcaat aatccaatct gcttctttca gtttttctgc 2661721 atcatcctcc agattgccag gtgtaatata ggaggtattt ttcgctgatg tgaggggagc 2661781 gggcttttgt ttcagcagtt ttttcatcgc ctgccggctc agcctgctgc gcacctccga 2661841 actgtccttc gtcagcccct ttttttcctc ttcctttgtc aaatcgttcg gcacaatatc 2661901 tagcagcagg acaggaattc cgatgttagc caaatgcgcc gctatcccgg aacccattac 2661961 ccccgatcct aaaacggctg ccttccgaat gtgtttgtgc atgagatatc ccccttgaac 2662021 attgaatgaa tagtcattca ttttttgact aaaaaaaatg aaacccgttt cttctttcat 2662081 cttaaaagat ttccggttcg acttcaatag ctaatttgtt atttttttgt atgaagccta 2662141 taaaagtcgg gcaacttaag cccggaggtg aagggaatgg tacgagagaa aaaaaatccg 2662201 tcttcagcgg cagtcagcgc ggcgagcgta aagggagatg ccggtccgac tcagcattac 2662261 ggcggcggaa aacggacaag tcaaaatcag cagtataaaa aacataacat gggacaatca 2662321 taatgcagct gcttcccacg gctgctttca ctttttcaaa attcctttta acacaaacgc 2662381 tgcattggca ggccgttcgg caattcttct cataaagtag ctgaaccagt ccgttccata 2662441 tgggacatac acacgcattc tgtagccttc cttggcgagt tccttctgac gctccggcct 2662501 gatgccgtat agcatttgaa actcaaattg cgatgcgggg atttgatgtt cggcgacgag 2662561 ctgtttcgta aatgcaatga tgtcatcgtc atgtgtggcg acagccgtgt agttcccgct 2662621 taacaactgc agctttatta agctctgaaa atgaaggtcc gtgcctcttt tgtcgggaaa 2662681 cgctacagcc gcagattctt tataagcgcc ttttacaagt ctgagattcg gctttaagtc 2662741 ccgcatcttt ctgatatctt ctgccgcccg gtacaaatac gcctgaatga ccgtgccgag 2662801 cttctcaaat tcctgtttgc attgcctgta aatagaaagt gtctgttcat aatgagaata 2662861 gtcttccata tcaatggtca cagcaacatc atattgcttc gcaacggaaa gaatggcgcg 2662921 caaatgagta agagcaagtt cttctgaaag atcgagcccg attgaggtca gcttaagtga 2662981 aagctctgaa ttcaattgat gttcggcaat ggcttgaatg gctttcttgc attcctctgc 2663041 gacttggttt gcttcttttt ccgaagctgc atactcgcct aaataatcaa ttgttgcaca 2663101 caaaccggat ctgtttagcc ttttgacggt cttaaccgcc gattcaatcg tatcccctgc 2663161 gacaaacctt cgtgctccaa gccgcgttcc gtatgctttt gcgaacttgg taagtgtttt 2663221 attttgagat aagaataaaa acacatgtct caacatccga ctccctcccg ccgtcatctt 2663281 caaaacacct gtatataact cccagtctga aggaaactat aaaatgaaca gaaaccaaag 2663341 gaggatcaca atggataatc agcagcaatc tcaaatgccg ccttccgtta tttcgacaaa 2663401 ggatcatttg tatctcaatg acatgctgaa ctggaatttg ctcgcgatga aaaaagcgca 2663461 tttcatggcg cagcagtgcc aggatcaaac gttaaagcaa gaactcgacc gcgtcggaca 2663521 catgcatcat gatcactatc aaagaatatt aaagcacctg cagccaggcc agcagcagtc 2663581 cggctacatc caataaggag gcgccagaat gaatcagcaa aatcaaaaaa tcagcaaccc 2663641 gcagacacct gtaccgacaa catcggaaat gaatgacaga gatttcgtca acgaattgct 2663701 gacaaccgaa aaatacatga caacagctta ttgcactgcc ttgcacgaat tcagccacga 2663761 gtctctttat caggatattc aatccatttt tgatgagtca caaaaagcgc aaagaaaact 2663821 atatgatctc atgttccaat atggatggta ttctgttgaa gcggaggatt cacaaaagct 2663881 gcagcagtcc tatcaaaaat tccagcagac cattcagcag cagtctcctt atcagcaata 2663941 acaacattag taaaaaggat acgatgttct ttcgggcatc tatccttttt ttgtgtaaaa 2664001 tcagttgact tttcatttac gcttatttat atttaataag cattaactat tttgtcatta 2664061 aaatatatat acagtgtatg taacagaggg gaaatgaata tgaagagtgc ggatcagtta 2664121 atgtccgata ttcaattatc gcttcaggcg ctctttcaaa agatacagcc tgaaatgctg 2664181 gaaagcatgg agaaacaagg tgtcacccca gcgcagctgt ttgtgctggc cagcctaaag 2664241 aaacacggca gcctcaaagt ttctgaaatt gccgagcgta tggaggtgaa gccaagcgcg 2664301 gtgacgctga tggcagatcg ccttgaacaa aaaaatctta tcgccagaac acacaacaca 2664361 aaagacaggc gagtgattga tctcagtctt actgacgaag gagacataaa gttcgaggag 2664421 gttttggcgg gcagaaaagc cataatggcg cgctatcttt cctttttgac ggaggaggaa 2664481 atgctgcagg cggcgcatat tacagcaaaa ctcgcacaag cagcagaaac ggatgaaaag 2664541 caaaacatga aaagaggaaa cggatgaaaa tgagtaaaga aggcaaacaa tcaaaacgaa 2664601 cgttattaat aacaggctta attattgcca tgtttttttc agcccttgac ggtaccattg 2664661 tcggaacggc catgccgaaa attgtcggtg atctgggcgg tttgagcatg atgacctggc 2664721 tgacaactgc atatttgtta acatcaacaa ccattgttcc aattgccggt aaactggctg 2664781 atttattggg acgccgcatt gtctatgtat caggtttgat tatttttatg gccgcttctg 2664841 ctttgtgcgg aatggccaac aacatgacgg aattgattat cttccgtgga ctgcagggca 2664901 tcggcggagg catcatgatg ccgatggcga tgattgtcat cggtgacttg ttcacaggaa 2664961 aacagcgtgc taaattccaa ggtgtctttg gcgcaattta cgggctggct tcagtgattg 2665021 ggccgcaaat cggcggctgg attgtagact cgttaaactg gaaatgggtt ttctatatta 2665081 acctgccagt cggaattatt gcggttattt ttattgccag gggattacag ggacgccagc 2665141 agactggtcc gatcaacttc gatatcgctg gtattttcac aatgattgtc ggtgtggtca 2665201 gcctcctgct cgccttaagc tttggcggaa aagattatgc atgggattca tggcagattc 2665261 ttgggttgtt cgctctcgca ctgatcggca ttgtcagctt tatcatcgta gaatcaaaag 2665321 caaaagagcc aatcctgcca atgtatttat ttaaaaacag aacatttaca tttctaaact 2665381 tgatcggctt ctttatgagt atcggtatgt ttggcgccat tacgtttgtt cctttcttta 2665441 tgcagggaat tgtcggtgta agtgcgtctg aatcgggtac aattatgaca ccgatgatga 2665501 tttctatgat tatcacaagt atcatcggcg gacagcttgt ttataaaatt gggattaaac 2665561 cgcaaatcat tacaggcatg ctggttatgg ccggcggatt cctgctgtta acgacattgg 2665621 atctcgacac gagcaagctt gtcgctacat cttttatggc gattattggt ctgggaatgg 2665681 gtcttgttat gccgattctg acattggctt tacaggaaag cttttcgaag gaggagcttg 2665741 gagttgtcac ttcatccagc caattcttcc gttctatcgg cggaacattc ggcattacca 2665801 tgctgggagc cgtaatgaat gcgagatcag gaaatctatt aacagataaa ttggttccat 2665861 atttagactc tcttccggca caggcaagct cgtttgccgc ccagctaaag ggtatgattg 2665921 atacaaatcc gcaagggctg ctgcaatcac tgttcagtcc ggacgcggtc aaacaaatcc 2665981 ctgcggcttt ctcatcccat attgtgccga ttttaaaaac atcgttgatg gattcgctcc 2666041 acagcgtgtt ttatacgggc ctgatcttta tcgcagtcgg agccgtattc accttgttct 2666101 taaaacctat caagctatca aataagaaag cggaagacca acaagaaaaa gagaaggcgg 2666161 caaaagccgt tgaatcacct tcccattaat agagcacccc gcgggtatca atccgcgggg 2666221 ttttttattc aatcatctgg gctcttccat ttccgaaaga ccaatcctca tcctgatttc 2666281 cggccagcat gataaacaca tcttcttttc ttacaccaag ctcggaatga atccggctcg 2666341 cgattgagcg gtaaagtgct tttttctgtt cagttgttct tgactgtttc agtgtaaaat 2666401 gaatgtatat cagttcatca gtacgctcga cttggagata aaatggatca taaaaaaatt 2666461 cgcttttttc atattgtctg atgacttgga aatagtcatc ttccggcaca ttgatttctt 2666521 caatcatcga ttggtggata gtcctgctca gtttttgaag ccacacttcg cttcttcccg 2666581 accgtaaatg aatctgtaca aatggcatct ccccgcatcc ctttctttac agcgtctgtc 2666641 cgctgtcaat tgtgataatt tggcctgtga gtgattcctg ttcaattagt gaacaaatca 2666701 atttggcaac atcatctggt tcagcaatac actgcagcag caaagagccg atcatgcttt 2666761 tcattttttc ttcccgtccg gcccaccatc tcgttgccac agctcctggt gctacaccgc 2666821 tcactctgat ttcaggcgct aaggcgtggg ccaatgattt cgttaaaccg tgcaccgctg 2666881 attttgatac tgcgtaaggc attgatgagc cggcaccagt tatccctgcg atgctgccga 2666941 cgtttacgat cgccccgtcc ttgcttttct tcatgaacgg aaccactgcc cgcgcgcaga 2667001 aaaacatccc tttcacattg acggcataca gctcatccta gacgtcttct gtcgcagcct 2667061 caagatcatc cattggaata tgccgtgtaa tgctggcatt gttgactaaa atatcaaccg 2667121 tgccgtgtgt gttcacgatt gcttgaatca tatcctgcac gtcgctgttt ttggatacat 2667181 ctgcttggat ggcgaaggct tgcccgccag ctttttgaat catttccact gtttcctccg 2667241 cttctgattg cgagcgtgaa taattcaccg ccacaatcgc cccacgcttt gccaattcca 2667301 tactggctgc ttttccgatt cctgtgccgc cccccgttac gagagctatt ttgttcaaga 2667361 cattcattgc cgccactcct tgctgttgac taaagtatat ttctgattcc attgtaatcc 2667421 agctttgatg ttacgtataa tgattgttaa agatactaga tatcactcag attgatagta 2667481 aacgaacgga ggagttcaaa atggaaagcg gagatttacg tgtgtttcaa atggtagctc 2667541 gtgaagggac cattacgaaa gcagccctgc agcttggcta tgtacaatcg aatgtcacgg 2667601 ccagaattca acaattggaa gctgagctgg gtaccacact gtttttgcgc cataatcggg 2667661 gcatgacact ttctgcaagc ggaaaattgc tgctggacta cgcaaataaa attataggcc 2667721 ttcttgatga agcgtctaaa gcgctctcat cctccgcaga accaagcggg ccgcttatga 2667781 tcggctgcac tcagacaacc gccgcggtaa ggcttccaaa gcttctggca tcttattatg 2667841 aagaacatcc aaacgtccag ctgtctttaa caacaggaca tacgcaattt ctccttgata 2667901 aagttcttcg ttatgaattg gatggcgcgt ttatcggatg cgaatgccat catcctgagc 2667961 tcgaatccta tcctgcgttt gaggaagaac cagtagttgt ttcggctgcc tccgtgcccg 2668021 atgttgagga agccatcaca aagccgattc tcgtttacag cacaggctgt tcgtatcgag 2668081 aaacacttga aaaatggctg cgttccgtcg gtgtcacaca gccggtcatt atggaatttg 2668141 ggacgcttga agcaattatc ggcggggtta cagcaggtct tggcatctcg ttgctgccaa 2668201 gaacggttgt gcagaaacat gaagcagaag gatcaattcg attgtacccg ctgcctgaag 2668261 ctctcagcca gatgaaaaca gagtttattg ttcgaaaaga ttcgtttatc agcagcgcgc 2668321 tgagaacctt tatggattcc tttacgccag ttaaaacggc tgaatcacaa aaaagcagtc 2668381 tgctataatg aacagactgc tttttggcta ttgtttgttt cgatgcgctt catttaattc 2668441 cttaatatgc tgaatgatct ctttaatgcc ctgcttcgcg tcggggtatg tcgcattcca 2668501 atgcttagcg agcggaggca tgcttttggc tatatgggtg tacaaaatcc attgcttcac 2668561 ttcttctttt agctcatcgt ttgtttcacc aagcagaagc tcagtatact tctccagcaa 2668621 tccatcaagc tgctcctgaa gtttttgttc cattttccat cttcctttcg aaaaaacagc 2668681 aaggagcttt ctcaattgaa agctccttcg ctgcgttatt tatccatgtg atgtgaaagc 2668741 cgcttcctgg acaatgcatc tgcccctgcc atgaggaatg caaagaggcg ttccgaagag 2668801 cgggtcctgt gtaacctgac agttcataga aaacacattt tgcacaagat cacaagtgat 2668861 gacctcttcc ggacggcctt ctgcataaat ccgtttatct tttatggcca caagatgatg 2668921 cgcatagcgg cacgccaagt ttaagtcatg gagaaccata acaatcgtcc ggtcttcctt 2668981 ttcattcagc tcaaacagca aatcaagaat ttcaatttga tgcgtcatgt ctaaatacgt 2669041 cgtcggctcg tcaagaagga tgatatccgt ttcctgggca agcgtcatcg cgatccaagc 2669101 ccgctggcgc tgtccgcctg acaaagaatc aacggcacgg tcagccatgt cctcaagctt 2669161 tgttgcttta agcgctcttt caactgcttc ctcatcctct tttgaccact gcttcagcca 2669221 gttttggtaa ggatatcttc cttgcttcac cagctgatgc accgtcagcc cctctggagc 2669281 cgaaggacct tggggcagga ttgcgagctc ttttgcgact tccttcgtcg gaagcttggc 2669341 aatcgctctt ccttccagca gcactgaacc gcctctcggc ttcatcaggc gcgctaatga 2669401 acgtaaaagt gtcgattttc cgcagccatt gctgccaata aatacggtaa tttcaccttt 2669461 gggaattgtt aaattcaact catcaataat aacggcatcc ccgtatccta agctcagcgt 2669521 ttctgtagaa attgcactca tacccataac cgctcctttt tgctggcttt ttagcagcac 2669581 tatgtattgc acgttttcta tatacatgct tttaagtcaa ttgtcatcaa tgcaaatgat 2669641 tccgatattc agccatttga tatggtcata tatccctcat tgtagcagaa aacactgact 2669701 ttgaaaatca ttttcaatta gttttatgga cataattgac gtttatgggt tttttatcac 2669761 aagattactt cttgatttct ctgatggagc cgtccttcag cttcaatttt aaatcgatat 2669821 gatcataatg actgtccaga ttaaatgctg ccagcacact gtgtatcact tctgtttcag 2669881 ccatttggtc tgtcacggaa agctcgctca aaatcatttt catctcatct aacgcttctt 2669941 ctccttcctg attgacaccg gagagcttat cctgtatttc cgctttttcc tgagtcccgt 2670001 tctttgtata gattccttca taacggttat gctcaccatc cccgtagctc acacgaagcg 2670061 aaaaattact gtagggaacg gacttcagct gggtgacggc tgtattttct ccttctgcct 2670121 gatgctggtc ttcattgaaa cggcagcccg caatcagaac cactgcgaga catacagccc 2670181 cggctgctct gatcaaatgc atatgtttcc cccctgtagg attccattta ttttaggtat 2670241 atccagagaa tgaaatcctc attcagagaa gaattgaaaa agccggggca tttaacgcca 2670301 cggctttttc tttaagattc ggtcatttgt aaaaaggttt cggcgtcacg cacagccagc 2670361 ttgatggcat tctcccagaa atcgcgcttt gtgatgtcag cgcccaaatg cttcatcgcc 2670421 aaatcctcca ctgtcataga agccgtatcg cgcaatagcg ccatatactt ctcttcgaat 2670481 gtgtcttttt cttcaagcgc caacgcgtaa ataccaagag aaaacaggta gccgaatgta 2670541 taagggaaat tgtaaaacgg caccctcgtg atgtgaaaat gaagctttga tgcccaaaaa 2670601 agcggatgat attcttctaa cgcattgcag tatgcctctc tttgcgcctc ttccatcagc 2670661 tcattcaagc ggctggccgg taccactccc cgctttcgtt cctcgtagaa tctcgtttca 2670721 aatagaaatc ttgcgtgaat gttcatgaag aacgcaacgc ttctttgcac tttatcctcc 2670781 agaagaacaa gcttttcttc cctcgtctcg gcctgctgga cagtcgcgtc cgccactatc 2670841 atctctgcaa acgttgaagc tgtttctgca acgttcatgg cgtaggaacg gtttaacggc 2670901 ctgacgttga gcattgcttc ctgatggaac gcgtgcccga gttcatgcgc aagggtagag 2670961 acatttgagg cgcttcccga aaatgtcatg aaaatccggg attccccgct gtccggaaaa 2671021 ctggtgcaaa agccgccgac tctttttccg ctcctgtctt ccgcctcaat ccagccgtcc 2671081 cgaaacgctt tttcagtgaa tgaggacagc tttttgccaa acgttgaaaa ctggctggta 2671141 atgatatttg cggcttcatc atacgaatag acctttccgt cagaaccgat cggtgcctcg 2671201 acatcgtacc agctgagttt ttcaaggccg agcatggatg ctttccggtt caaaaactga 2671261 acgaacggct tcttgttttc agtgatgacc tgccacatcg tatcaagtgt ttcttttttc 2671321 atcctgttaa tttgcagcgg ttccttcagg acattctccc agccgcgcgc tttataggtt 2671381 tcaagccgga atcccgccaa atgattcagc gtgctgctga aaatatcttg cttgctctcc 2671441 caagcttggc ggaaacgttc atatactgtt tttctgacag tacggtcttg atgatccatc 2671501 atattctccg cctgaccgac agacaattgc ttgttttcac cgttttcctc atacgggatc 2671561 gtcattttcc cgacaaccat attgtataag tcactccaag cgtgatatcc gtccaccgca 2671621 aggtttccga tcagtttttc cttaccgggg ctaagctttt cggcaaccct ctgtcttctt 2671681 tcatttaata tgtaagaaac atcgcgcaat cccggttttg ttaacaattc attccacacg 2671741 tcttgattaa tgtccacaag tttatgatct aatgtaacga gcgacgattg aaaatctgcg 2671801 gaaagccgat tcatgaggcc tgatgctcta tagccttttg atcattgata ttctgggcct 2671861 ggaggcaagc aacaaaagcg ccggcctgct gaagcttgac ggatgtctgt tcgaataaat 2671921 caagcaacgc ggtcagccct tcagcctctt caggcgattc aggcacctga aacgcatcag 2671981 tcctgtcttg aaatgcacgc agactttgtg acagcttctc aatataacct ttgaattctt 2672041 ccgattggct cccgccctta aaaaatgaat caagatccca tctttggcct accccttgca 2672101 gcgccatatc acaaaacccc tttccttctt tcgttctatt atagaacaat tctgaattat 2672161 tgtataaaaa tttctattac aggcgtcatt tcgtgttcag gatagtacaa tagctgtagc 2672221 agtttaatag gagggttagg atgaataaaa aaatagccat cgtgacagga gcgtccagcg 2672281 gcttcggtct gctggcagct gtaaagcttg cccgatcatt tttcgtgata gccacatcaa 2672341 gacagcctga aaaagcggaa cagcttcgag aattggctgc agcacacaat gtgtctgatt 2672401 ctattcacat tacagctctc gatgtcaccg atgaacaatc tatagtctca ttcggaaaag 2672461 ctgttagtgc ttacgccccg atcgatttac tcgttaacaa cgccggaacg gcttatggag 2672521 gatttatcga ggatgtgccg atggaacatt tcagacaaca atttgaaacg aatgtcttcg 2672581 gtgtgatcca tgtgacaaaa accgtgctgc cttacataag aaagcatggc ggcgcaaaga 2672641 ttataaacgt gagcagcatc agcggactga caggattccc agcgctgtcg ccatatgttt 2672701 cttccaagca tgcattggaa ggtttttctg aaagcctgcg tatcgagctg cttccgttcg 2672761 gtatcgaaac cgctttgatc gagccgggct catacaagac atcgatctgg tcaacgtcat 2672821 tatcaaattt tatgtcggtg cctgctgacg attcagccta tcatcaatac tataaaaaga 2672881 tcctttccta tgttcaaaaa aacggagaag aaagcggaga tccccaagag gttgccgacc 2672941 tcatttatca attggcaaca aaacagcaca taaagaattt gcgatacccg atcggaaagg 2673001 gcatcaagct caccctgctg ttccgatcgc tttttccttg gtctgcgtgg gagtctatcc 2673061 tgaagaaaaa gctattcagc tgatctaaat tataattatt ataatttagt attgattttt 2673121 atttagtata tgatataatt aagtcaacag atcacaagga ggacgttatc ttatgaaaac 2673181 tgaaaacgca aaaacaaatc aaacattagt tgagaattca ctgaacacac aattatcaaa 2673241 ctggtttctt ttatactcta agctccaccg tttccattgg tatgtgaaag ggcctcattt 2673301 ctttacattg cacgagaaat ttgaagaact ttatgaccat gcggctgaaa cagtggatac 2673361 catcgctgag cgcctgctgg cgattggcgg acagcctgtt gccacagtga aagaatacac 2673421 tgagcatgca tctatcacag acggcggaaa cgaaacatca gcatcagaaa tggtacaagc 2673481 attggtaaac gactacaaac aaatcagcag cgaatctaaa ttcgtgatcg gcctggctga 2673541 agaaaatcaa gacaatgcga cagcggactt gtttgtcgga ttaattgaag aagttgaaaa 2673601 acaagtgtgg atgctttcct cttatttagg gtaacaaaaa agctgaacct taatcgggtt 2673661 cagctttttg ttttttctta gcttgaactg ctttctgtct gcttggtcag tgttgcgttc 2673721 aacgttttcg tttttccctt tcgcagcact tggattgttg ttttatctcc gacttttaag 2673781 tctttgtaaa ggatctgacg gatatccgca ctgctttcca cgtctttacc gtttagtttg 2673841 acaatgacat cctcagattt aatacctgct ttttctgccg gcgaatttgc ttgaacttct 2673901 tttacataaa cacctttgcc caattgatct ccaaacaggc cgagcgtatt ttcctgatag 2673961 gtttcaggaa cttgtgacat gtcaatcatc tgcacgccta aaaacggacg gtccaccttc 2674021 ccgttttgca gcagctggtc aacaatcggc tcgacatcat tgcttgggat cgcaaatcca 2674081 agtgattcca cgccgctttc gctcaccttc aagctgttga tgccgatgac ctggccgctt 2674141 gcattgatta atgggcctcc gctgttcccc ggattgatcg ctgcatcggt ttgcagcacg 2674201 ttcatttcca ccgtcccctg tgttgtatcc acatcaattg tccggttcag tccgctaatg 2674261 ataccttgtg tcactgtacc ggaaaactgc tgtccgagcg ggttaccgat agcgattacc 2674321 ttttcgccag tgcgcagctg tgaagagtca ccaaagctcg ccactttttt tacattcttg 2674381 ccgctgattt ccaaaactgc caaatcagta atggtatcgc tgccgacaag cttggcagtt 2674441 tccgtttctc cgttgtatag cgtaacagtc agcttgttcg cgccttcaac gacatggttg 2674501 tttgtaatga tatacgcttt atcgctgtct tttttgaaaa taacacctga cccggttccg 2674561 ctttcacttt ctgagctgga gcctcctccc gtgccgaatg tgttattttg agaggtttgg 2674621 atatttgaga ttccgacaat cgtaggctct aaatcctcta ccatatcagc gatgtttgat 2674681 gcgttcgtta tcggcgccgt tgtaaaatta tcagactgca cctgtttatt tgcggaagcg 2674741 gtttcggtcg cctgattttg gtctgacggc agataaggcg cgatgccaag catgaggccc 2674801 ccgccgataa taccgcctaa aatcgggctc agccatgcgg ctctccgttt cttttctttt 2674861 ttcacagccg tttcttgctt ttccatttct aaagcagaag ccgtttcctg ccgtcccgct 2674921 tcatacgaca caggcgcgtc aagcaattct tgttcagaat gtccaatcag cttctggttt 2674981 tctgtattct gctgttctgt atgtgaaggt tcagtttgat gttgatcgtt ttggccatca 2675041 cgtcgataat ccatgttctt acactccttt aacggttatt catttatcgt tacatattca 2675101 tcgcatgtac aagttcaatt gtcccaataa tgaggagaaa agcaaagcac caaaatagaa 2675161 tatgtttgat catcctacat cttcctcgct ctttttctct tcctttcttc ccttaaccat 2675221 atcataaaca aacattgtgg gataaaaatg aaaagaatat gtgaaattat gaaaattgcc 2675281 tgccgtatgt taaaactagt ttataatgac gttgaaagga tgtgaagagc cttgtcatac 2675341 accatttatc tagttgaaga tgaggataac ctgaatgaac tgctgacgaa gtatttagag 2675401 aatgagggct ggaacattac atcttttacg aaaggtgaag acgccagaaa gaaaatgaca 2675461 ccgtctcccc acctatggat tctcgatatc atgctgccgg ataccgacgg ctatacatta 2675521 ataaaagaaa tcaaggcgaa agatcctgac gtgccggtca tttttatttc cgcccgagat 2675581 gcggatattg acagagtgct tggcttagag cttggcagca atgactacat ttcaaagccg 2675641 tttttgccgc gggagctgat tatccgtgtg caaaagctgc tgcagctcgt atataaggaa 2675701 gctcctcctg tccaaaaaaa tgaaattgcc gtctcctcgt atcgggtcgc tgaagacgcc 2675761 cgcgaggtct atgacgaaaa cgggaatatc atcaatttga cgtcaaagga atttgatctg 2675821 ctgctattat ttatccatca taaagggcat ccatactctc gtgaggatat cctcctaaaa 2675881 gtgtggggac atgactactt cggaacagac cgggtcgttg atgatctcgt ccggagactg 2675941 cgcagaaaga tgcctgaatt gaaggtggag acgatttacg gtttcggcta caggatgatg 2676001 tcatcatgaa aaacaagccg ctcgcgtttc agatatgggt tgtcatatcc ggcatcctgt 2676061 tagcgatatc gattttactg cttgtgttat tttcaaacac gctgcgagat tttttcacta 2676121 atgaaacgta tacgacgatt gaaaatgagc agcatgttct gacagagtac cgcctgccag 2676181 gttcgattga aaggcgctat tacagcgagg aagcgacggc gccgacaact gtccgctccg 2676241 tacagcacgt gctccttcct gaaaatgaag aggcttcttc agacaaggat ttaagcattc 2676301 tgtcatcttc atttatccac aaggtgtaca agctggctga taagcaggaa gctaaaaaga 2676361 aacgttacag cgccgacgtc aatggagaga aagtgttttt tgtcattaaa aagggacttt 2676421 ccgtcaatgg acaatcagcg atgatgctct cttacgcgct tgattcttat cgggacgatt 2676481 tggcctatac cttgttcaaa cagcttctgt ttattatagc tgtcgtcatt ttattaagct 2676541 ggattccggc tatttggctt gcaaagtatt tatcaaggcc tcttgtatca tttgaaaaac 2676601 acgtcaaacg gatttctgaa caggattggg atgacccagt aaaagtggac cggaaagatg 2676661 aaatcggcaa attgggccat accatcgaag agatgcgcca aaagcttgtg caaaaggatg 2676721 aaacagaaag aactctattg caaaatatct ctcatgattt aaaaacgccg gtcatggtca 2676781 tcagaggcta tacacaatca attaaagacg ggatttttcc taaaggagac cttgaaaaca 2676841 ctgtagatgt tattgaatgc gaagctctta agctggagaa aaaaataaag gatttattat 2676901 atttaacgaa gctggattat ttagcgaagc aaaaagtgca gcacgacatg ttcagtattg 2676961 tggaagtgac agaagaagtc atcgaacgat tgaagtgggc gcggaaagaa ctatcgtggg 2677021 aaattgatgt agaagaggat attttgatgc cgggcgatcc ggagcaatgg aacaaactcc 2677081 tcgaaaacat tttggaaaat caaatccgct atgctgagac aaaaatagaa atcagcatga 2677141 aacaagatga tcgaaatatc gtgatcacca ttaaaaatga cggtccgcat attgaagatg 2677201 agatgctctc cagcctctat gagcctttta ataaagggaa gaaaggcgaa ttcggcattg 2677261 gtctaagcat cgtaaaacga attttaactc ttcataaggc atctatctca attgaaaatg 2677321 acaaaacggg tgtaacatac cgcatagcag tgccaaaata gactgtagat gttttgcagt 2677381 ctattttttt atgtgaaaga atagccgtta aaatctctgt aatttgtttt gagcggctgt 2677441 ttgcattgat gaacccattt tttctctgac aaggtctgct tcggatattt gactttctcc 2677501 actttgattc ctctgtttcg caagcggctg atcatttcgt ccaattctct cattctagat 2677561 tcaccctttc gcttgagctt tgaccattcg gtcatctcaa tttataatat aaataataca 2677621 tgataaaaaa acaagttaca ataaggttaa ttttataaca gacggtgtga ctatatggtc 2677681 atatcctagc aggcctccgg gctccgaaag ggtggaacca ttgaaggaaa aagaaaaact 2677741 gattattgaa acagccttaa aactatttgc ccaaaaagga tacaactcaa catcagtcca 2677801 ggaaatcgca aaagaatgca aaatatctaa aggcgctttt tatatttatt ttccttcgaa 2677861 agaagcgctt cttctctcta tgctgaacta ctattatgat aaaacgttta cccgaatttt 2677921 aaatattaaa acgaagggcg acagccccag aacggcttac cgtaaacagc tgaccgtcct 2677981 ctatgaaaac attcttgaac acaaagattt tatcagcatg cagttgaagg agggttctct 2678041 gccttacaca gaagaagtgg agcaatgcgc aaaaaaaatc cgccagtcct cacttcaatt 2678101 tcatatcgac agcctgctga acatctatgg aaaaaaagcg gaaccgtaca ctgctgagct 2678161 ttgtttttta atagagggca tcagccagat ttacctggaa tgcatgattt tgctcgggta 2678221 cactgtgaag ccgtctcaat tagctgatat cattatgaat cgaattgatg atatggtaaa 2678281 aggcatgtct gaacgaaacg ataagccttt catcacattg gaagaggcga gctctttatt 2678341 cggacctctt acgcacggac ggcctgaccc gctgactgaa tcaattgtga aaagcctacg 2678401 tgacaaaatt aacagcttaa acacaaactc ctctcttgaa ttatcggaga gcttggacat 2678461 acttgaagca gaaatgaaga aaaaaacacc gaagctggcg atcataaaag gaatgattca 2678521 taatctgacg gagtctgaag ctctcgccaa agatgcggaa cagcttaaat atttattaaa 2678581 acagcaacat atttagaaga acggctgctt aaaaagcagc cgttcttcct attacgcctt 2678641 tggttttacc atgtcttccg gcttaaccat ttcgttaaat tgctcctctg tcagcaattc 2678701 aagcttcaaa gctgcttctt tgagcgtcaa tccctcttta tgggcaagct tggcgatttt 2678761 cgccgcgttt tcataaccga tatgcgggtt cagcgccgta acaagcatta atgaatttga 2678821 caggttttcc tgaatggttt ctttattagg ctcaataccg acagcacatt tatcatggaa 2678881 tgaattcatg ccgtcactga gcagctgcac agattgcagg aagttgtaaa taataacagg 2678941 cttaaacacg ttcagttcaa agttcccctg actcgccgca aagccgattg tcgcatcgtt 2679001 ccccatgatt tgcgctgcga tcattgttaa cgcttcgctt tgtgtcggat tgactttacc 2679061 aggcataata gagcttcccg gctcattttc aggaatgacg atctccccga tgccgcagcg 2679121 gggtccgctt gcgagccatc tgacatcgtt cgcgattttc attaagtcag ccgcaagcgc 2679181 ttttaatgcg ccatgcgcat aagtgatttc gtcatggctt gtcagcgcgt ggaatttatt 2679241 cggcgagctg ctgaacgttt ggccggtcag cttagtgatc tcttctgaga caagctctcc 2679301 aaactctggg tgggcgttga tacccgttcc gacagccgtt ccaccaattg caagcgcacg 2679361 cattttatct gtcgcttcca aaatcatttc cttcgaacgg tccagcatgt gaacccatcc 2679421 gctgatttcc tgtccgaggg tcagtggcgt agcatcctga agatgcgtgc gtccgatttt 2679481 gacaatatca ttgtatgctt ttgctttttc atccagtgta ttgcgaagct gatcaagcgc 2679541 cggcacaagc tgctcgtaaa cagccaaaac agcggcaaca tgcatcgcag tcgggaatgt 2679601 gtcgtttgag ctttggcttc ggttcacgtc atcatttgga tgaatcgttt gatcagagtt 2679661 cttctctttt aataaagcag tcgcacggtt ggctaccact tcgttcatgt tcatattgct 2679721 ttgtgtgccg cttccggtct gccatacgac aagcgggaag ttgtcatcgt acttgccttt 2679781 gagcacatca tcacaaaccg ctgcaatcgc ttctgctttt tcagcgtcca gattgccgag 2679841 gcgtttatta gctagagcag tgcttcgttt taaaattgca aacgccttca caacacgcat 2679901 cggcattttt tcagaaccga tcttaaagtt ctccttgctt cgctgtgttt gggcgcccca 2679961 aaatttatca gcaggaactt ttacttctcc catggtgtct cgttcaattc tgtattccat 2680021 ttatgtatcc ctccataacg gttgcttcaa tagatcataa ttcgccaatg acacaaaaaa 2680081 tcctttttat ttttcgatct tggcagattt taattttaat tcaagatata cgcgggaatc 2680141 ctttgaatat ttgtattttg gatttgtcct gccgtactcc tttgatgtat aagagacatc 2680201 ataatgctgt tcaaatgatc taatgagctg ttcaatttct tcttgttttc cagctagcct 2680261 tacctgtgcc acttcgtatc ctccgctttc ataaaaaaac ttactccatg aaatactcta 2680321 acacagtata tcattttttt aacaggaaaa gataacctct actaaggttt tggataagag 2680381 gtgacctcat tggaacaaac agagtttaag gaatatatac acgataattt agcattggtg 2680441 ctgccaaaat taaaagaaaa cgatgatctg gtgaaaaaca aaaaaatgct tgcgaacgga 2680501 ctggtttttt actatctcta tttcagtgaa atgactgatg agaataaggt gtcagaagcc 2680561 attaaaactt tgattaaaga tgaggagacc ttaacgcttg accaggtcaa aaaacgcctt 2680621 gaccagcttg acgcaagacc tgttgaaact gcaaaaaaaa cgattgaatc gattctcaac 2680681 ggcaattgtg ctgtgtttat caacggattg gataaagcct atattctgac cacaggaaag 2680741 aaaaaaacaa gaagcctgac agagccgaca actgaaaaag tggttcgcgg cccaaaagta 2680801 gcgtttgtag aggatattga tacaaatctc gctctgatca gacaaagaac ctctcatccg 2680861 aaattgatca ccaaaaaaat catgatcggc gaaaacaagc tgaagcctgc agccattatg 2680921 tacattgaag gcaaagcaaa aaagtccgtc ataaaagaag tgaaggcgcg gcttaaaaat 2680981 atccagctgg aagatatcca ggacagcgga acgctcgagg agctcattga agataataaa 2681041 tattcaccat ttccgcagat acaaaatacg gaaagacctg acaaagtatc ttcagccctg 2681101 tttaacggcc gtgtggcaat tttggtcgac agttcaccat ttgtgctgct ggtgccggtt 2681161 tctctcggca tcctgatgca atccccggat gactactatg aacgctggat ttcagcatct 2681221 cttatccggt cgctgcgctt tgcttctatc tttatcacct tgtttttgtc atcgatttat 2681281 ataacacttg tttccttcca tcaggggctg ctgccgaccg cactcgccgt cacgatttcg 2681341 gcgaacaggg aaaacgtgcc gttccctccg atatttgaag ccctgctgat ggaagtcacc 2681401 atcgagctgc taagggaagc cggactgcga ctccccaatc cgctcggaca gacgatcggc 2681461 ctcgttgggg gcgtagtcat cggacaggct gctgtagaag cgaatctcgt cagttcgatt 2681521 ttggtcattg tcgtcagtgt cattgccctg gcatccttta ccgttcctca atacggaatg 2681581 ggtctgtctt tccgggtgct gcgttttatt tcgatgtttt ccgccgctat tttagggcta 2681641 tacggcatta ttttatttat gcttgtcgtt tatacgcact taacgagaca aacgagcttt 2681701 gggtctccgt atttttcgcc aaacggattc tttagcctga aaaatacgga tgactccatt 2681761 atccgtctcc caattaaaaa caaaccaaaa gaggtgaata atccaaatga gccaaaaaca 2681821 gactccactg aaacttaata cctttcaagg tatttctatt gttgcaaata caatgcttgg 2681881 ggccggactt ttaacattgc cgcgagcgct gaccactaag gctaatacgc ctgacggctg 2681941 gatcacgctg atattagaag gtttcatttt tattttcttc atttatttaa acacgctcat 2682001 tcagaaaaaa catcaatacc cttcactctt tgaatatttg aaggaagggc ttgggaaatg 2682061 gatcggcagc atcatcggcc ttttgatctg cggctatttc ctcggcgtag ccagcttcga 2682121 gacacgggca atggctgaaa tggtgaagtt tttcctgctg gagagaaccc caattcaagt 2682181 cattatttta acgtttattt gctgcggcat ttatttaatg gttgggggct taagcgatgt 2682241 gtcgcggctg tttccctttt atttaacggt aaccattatt attttgctga ttgtgttcgg 2682301 gatcagtttt aaaatttttg atatcaataa tttgcgtcct gttttaggcg aaggccttgg 2682361 acccattgca aactccctta ccgtcgtttc catctctttt ttaggaatgg aagtgatgct 2682421 gtttcttcct gaacatatga agaaaaagaa atacacgttc agatatgcgt ctctaggatt 2682481 tctgattccg attatcttat atatccttac gtatattatc gttgtcggag ctttgaccgc 2682541 tcccgaggtg aaaacgctga tttggccgac tatttctctc tttcagtcct ttgagcttaa 2682601 aggcatattt attgaacggt ttgaatcctt tttactggtg gtctggatta tccagttttt 2682661 caccacattt gtcatttacg gatactttgc cgctaacggg ctaaagaaga catttggatt 2682721 atcgactaaa acaagcatgg tgattatcgg cataacggtc ttttattttt ctctctggcc 2682781 ggatgacgcc aatcaagtca tgatgtatag cgattatctt ggctatattt ttgtctccct 2682841 gtttctgctt ccgttcattc tctttttcat tgtagctctc aagaggagga ttacaacaaa 2682901 atgaaaatcc ggattttatg tatgtttata tgcaccctat tgctgtccgg atgctgggac 2682961 agtgagaata tcgaggaatt aagcttagtg atcggaatag ggctagacaa gcctgacgat 2683021 gaaaatttag agctgacaca gcaaattctc gtgccgaaaa taatcagcgc caaggagggc 2683081 tcttcatctg atccgacaca gctttctatc acaaagggta aaactgtcca tcaaatgatg 2683141 agaacctctg cattaaagca taagcctacg ttttcacagc atttgcgtct cattctgctt 2683201 tccaaaagcg tgattgcgga tcaaattgga atggacgcca ttattaacca gtttgtcaga 2683261 gacaacggaa caaggaggag ttcctacgtc tttatcacca acggccgaac taaggatata 2683321 tttaacatga atgatgaagg cgaacccgca tccaacgtga tatatgatct gacagagaat 2683381 aataaggtga cgatcagaac gatggagcca gttacattgg gggagatctc agaacactta 2683441 acctctgacg attcattcct catccctcat gtcggtaagg aaaacggcaa gctcgcgata 2683501 aacggagcct ctatcataaa aaataaatta tggcaccggg acctcacccc gattgaggtt 2683561 caaaatatca gcttattttc aggcactgtc gagggaggcg tcattgactt gaagcgcgat 2683621 ggccatctct tttcttatga agtatattca agcaatcgga agatcaagac ggcatacaag 2683681 gacggaaagt tcaaattcac cgttacccgc aatattgaag gtcgtctatc tgaggactgg 2683741 aatcccaatg aagactcgtt taaggattca tatattaaaa gtattgaaaa gacagtcgaa 2683801 aaacgagtac acgaaacagt aacgtcattt attacagaga agctgcagaa agagatcaaa 2683861 gcggacgtaa ccgggctggg aaacgaggtc agaattcatt atcctcaaaa gtggaaaaag 2683921 atttcaagaa aatgggatga tgattatttc agcaatgcgg aaatagacta ccgggtcaat 2683981 gtgattgtca gagacttcgg aacgaaaggc gcaaacaaat agcagccgcc taattcacga 2684041 gatgatttcg gtgtgcgtac accgccgcct gcgtccggtc actgacatcc agctttgata 2684101 aaatattcgt aatatgtgtt ttgactgttt taatcgtaat aaacagttcc tcgcctattt 2684161 ctttgtttgt ctttccttct gcgatcaggc agagtatttc gagctcccgt tttgtaagcg 2684221 attcatgcgg gagcgcgttt tcacctgagt ggcgcagcct ggataatact tttcccgcca 2684281 cttttgactc cagcttcggc tctcccttgc ttgcggcgcg gatggcatcg gcgatttctg 2684341 ccgcttttga ggttttcaac agatagctga gcgcgccagc ttcaataacc gggtacactt 2684401 tgtcatcatc aatgaagcta gtgagcacaa taattttcgg gtcggaaagc tcccggcaaa 2684461 tttgctttgt agcttcaatg ccatccatgc cctccatgac aaggtccatt aaaatgacat 2684521 caggcgacag ttccacagca agccgaacac cttcgctgcc gtccgatgct tcgccgatga 2684581 cttcaatatc gggctgcgcc tccaaaaaag ccgcgagccc cattctgacc atttcatgat 2684641 catcaatcaa taatactcga atcacgttcg ttctctcctt tttcttccgg aaaaatcggg 2684701 accttcactt cgatttgagt gccttttcct tctactgaaa tcacttcggc gacaccgccg 2684761 atttcacttg cacgttcttt catagaattc aagccgtatg aggaggcttt cacctggtcc 2684821 attttaaagc cttttccatt atcaatcacc ttcagacgga gctggctgtt ctttatgccc 2684881 agaatcacgg ttacttttga cgcttttgaa tgtctaaata cgtttgaaag ggcctcctgc 2684941 acgattctga acaagtggtc ttcaacaccc ttggatatcg ctgtgtcctg tatatcccac 2685001 tcaatatcaa tcggctgctt ttttcggaac tcgtccaaaa gctccgtaag gccctccttc 2685061 agcccttttc cttcaagggt aacaggccgt aaatggagca gcagcgccct catctcattt 2685121 tgggcttcgc ctgccatatg ctcgaccatc ctgatccgct tgactgtttt gtcatcagca 2685181 tccttgacat gttccagcac ggctgatgtc atcatcgata tggcaaagag ctgctggctg 2685241 accgcatcat gaagatctct ggccaatcgc tggcgttctt ctgagataac cgacttcttc 2685301 atttgagcct gccattccgc acgttcattg gaaagtttct ggagggatgc gacttgaagc 2685361 tccacgcgct tcgccatttc gttcagctga tcagcagcca ggccgatttc atcatcaccg 2685421 agcggcggta tccgataagc gaaattgccg ttttcaaagg ttaaaatgga ttcaattaat 2685481 gtatcaatcc ttgtcttcaa ccggttgccg tacatatacc ctgaggcgaa accgacggtc 2685541 acgctgatca gaagcaaaat caggataaac ggaattccga accagcttga tgacagcaaa 2685601 acaagcggat cgagccgata gtaaaacatc ataaaggaaa tcaggcaaac aaaaaggagc 2685661 aggctgattc ccgttgtcat gcggatggcg cgccattgga ggctggcaag catttttttt 2685721 ctcatacgta cttcacatcc acatcaccga taaataagga aacggacact tttacccggc 2685781 gctttgactc gctaaaatca gttgacgcgg catatacctt cgtgcttaat ccgcttttct 2685841 tcgagccgat cagattaatg tctcctataa aaacagccga gctgacagcc acttcaaggt 2685901 ccgatggtac ataaatatca acgttaccaa tgactccgct aatgacgatt gtactttctc 2685961 cctcgggaat catcgcttta gataaatcga ttttgatatc accgataaaa ccagagacat 2686021 ttaaatcgtt caggtcaaac ggctgcttca tcatttgcag ctcaccgata aaaaagctgc 2686081 gcatgtcggg atgttttaca tcttttggcg gctcatgatg ttctttttta ttgagattga 2686141 cctgtttctc attcggttca aatatcggct tccctttgat aagcctgtag ccggcgtaaa 2686201 tcagaaatgc ggcaaacgca tagccgaata aattaaaggt gatgctgaag aggtttttca 2686261 aaaatagaaa cgcggcaaag atatacatga cggagccaag ccaatcacgg gaatattttt 2686321 taaggaaata gccggcaatc agaaaaaaga gcggccaaaa cagcagatcg cctattccga 2686381 taatttgcaa aaacatactg atgccgaata aagcaatgat caatccgaga agctgttttt 2686441 ttgtcattcc tggtgtccgc ctcctttctt ctgcctagtg ctaccgtatc gctagatccc 2686501 cgctgtccgt tttgatgtcg attggatgcc ggccgcttcc ttgcgtgcct gtgatgtgat 2686561 gctgttcttt atgtccttta tcagcaaatg aatacggcga actgacgtca ccgcttgctg 2686621 ataaagcatt gactgcaaag ctgccatttt ggggaaggct tacattagca tcaccgcttg 2686681 tcagcgtgac agatacggga ccggttacct ttttcaatac agcattaaaa tctcctgaag 2686741 tcattttcac atcaagagag cctgatacat gaaccagatt tgcgtcccct gaagctaaat 2686801 caatgccggc tgttttggag acggtatttg aaatggaaac atcccccgat gatgccttca 2686861 ctttcagatc ttgaatgcgg acgtccgtca cgctcgtatt tccgctcgca gatactgcgt 2686921 tcagcccgga aagcgcaaga tggtcattcc cggccacaga cacgtcaccg cttgaggttc 2686981 gtactgccag atcaccttta taatcatacg gaagcctgac gataagagtt gaacggttaa 2687041 atccattcaa aaattgaaat tctttttcct ttacggtcag ctccagtttt cttttgtttt 2687101 cagtaacaaa taactttcct gagtctcctg aaatgcctgc cgatatgtca cttcgttctt 2687161 ccgctataat ccggacatcc ttgctatccg actcaatgac catgctgtca atgtcccgcg 2687221 gcgatgcgct ggctgaatca gcttctgtgc catttatgaa acctaggcct gcagcaaaca 2687281 catcttttac gacgacggcg aaaaaaacca gaataccggc agtgatcaac agtttgccaa 2687341 gcattttttt cattcggttt catccttctc attcattcta ttataaagga aaagcttgcg 2687401 aattgatacg tgcggaaggg aaggacttga ccgcaaatcc ttccccgttc cgcttattca 2687461 tttgccgctt ttgtctggtc tgatttttgc agtgaaagtg tccgcatttt ttcaatctcc 2687521 gcttccacat cgtctgcgaa ttctttacgt gtaagttctg tgccggcttc cgctgacttt 2687581 gaataattcg cgcggatttc catttcttca atacgatttt caatacgtaa aaattcacga 2687641 tacgcgcttt cactgtcaat tttgtcaaat gtcgtattca tatgctcttt agctttcgcc 2687701 gcatttgccc gcgcaatcag cgcctgtttt ttatccttta cgtcctgaag ctttgtttca 2687761 agtgcagcca gctgctcttt cagatcagcc agctgactgt ttgcctgttc ataggaagct 2687821 ttatgctcag ccgccttccc ttctaaatac ttcatttcag tcagcgcctt tttcgccagt 2687881 tcttcttcac ctgcgtcaaa tgcgagctgt gcctgatttt tccgtttgcc agccacttca 2687941 gcggcttctt catatttttt cttaaattga taggcaatcg tgtgctgttt cacaattgtt 2688001 tgctttgctt ttgcgatgtc gctttccata tcgcgtacat attgattcag catcaccttt 2688061 ggattctcca ttttatcaag tccttcatga actgacgcaa caaacatgtc tctgattctt 2688121 tttaatacca tacctgattc ctcctaatat attgatatta ttttttcttc aaaaattctt 2688181 cccattcgtc atcaaagtga gattggtagg cagcagaagc cggttcagga tcaaaagatg 2688241 atacaccgtt atcagctgat ccgtttttca tcagcttcca gccgtaatac accatagcgg 2688301 ccgccaatgc gattccgacg acaaacggaa gtgagcagat gagcataatg gctccgatac 2688361 cgcccacgat gattcccgtg atggtttttc ccgcggcaaa ccttttgatt cctgcgtatg 2688421 tcatcaagct cccgatggcg agcgggatga taaagccgaa gcttcctcct ccaaaaaaga 2688481 cggagatccc aaatacaatt aataagaatc cgcctattgt tttcttgttt attttcatgc 2688541 agatcctcct ttcgttttcc ttgtcttcat cttatacaag ttggaagata tgcaaaacga 2688601 atcagagatt gatttttata taagaccgga gtcgtatctc gcaccggacc cattggcaca 2688661 aaaaaacgcc atgcacgagg catggcgttt taaaaccctt tacagatgaa cacttgcttc 2688721 cctttcttta attaggtcgg acctttctgc tttggccaat tttgtaaaca gcaagattcc 2688781 gatacccgca ataatttcga caatcccacc gacagcgatc actttacctg agccgaaagc 2688841 attagcggca tacccgcaaa tgacagctcc ggcagggatc gaaatatttg agatcatatg 2688901 tataacggcg taaacctgcg gctgatcctc actatccaca gacgtctgga taatcgtgta 2688961 ctcaggaaca ttaacagcac tgactgcggc accaaaggta aaagcagcga aaaagacgag 2689021 cggcaaaaag gtattcatcc cggtaataaa gaaagcaaat ccttcaataa tgccggcagt 2689081 gacgaataac aagccgtacc tgtttacctt gactttcgcc agcacaaacc ctaataaaaa 2689141 cgcgcccgcg gcggtggtgg cctttaaaag cgagtatacg atcggctggc cgtttaaatc 2689201 ttccgcaacg tatacggcag agagcgcttc ccatggggca gccgcgaaat tcataaagat 2689261 acagtaaatg gcgagcggat ataaaatctg gtgttttctg acgagcctaa agccgcgttt 2689321 cagtcttccg atatatgtgc ctctctgtgt aacaaccgca gactctgatt gagattcaac 2689381 cgcagtgtac ttaataaaaa gaacgagaaa acctgacacc aaatagagca caagtgcgat 2689441 aagcatggta taagaaggac taataaatgt aagaaaagcg ccgcataatg tgacagcccc 2689501 aagccggaca atttgagcgg aggattgcag cacagcgttt gctttttgaa tgccctgttc 2689561 attgacgatt tgaggaatca aagcgataga ggcgggattg taggcagctc cagtagctga 2689621 atgcacaatc ataagcgtca tgacaaacca cagcggagag aagcccgcaa aatgacatag 2689681 agggataatc aaaacaatcg ccgcccttgt cagatctgaa aagtacatcc aaaatttcag 2689741 cgtggtctgt ttcataaaag gccccgtcac aggcgccaga acggcttccg gcaaaaacgt 2689801 gacagcaatc aataaagcag tgccgatcgc acctttgccg tcataaatta aaaaccataa 2689861 tattgaatta aatgcgaaca tatcgccgga tatcttgact attcttgaga aaaacagata 2689921 attgaaattt ctcttccaga tgctatcact ttcaattaaa ttcaccatcc atcagagccc 2689981 cccgttgcct attttttaca tctatttatt acaatatctc atttttccat ttttcagtca 2690041 ataattcata aggttcattt tttgtcgtaa aatgggaaat tgacagagtg aaaaacaaaa 2690101 aaagccggca tgtatttgaa cacgccggct ttccttttca ctttttatga ttcgctgctg 2690161 tttcggtccc gaaacacaat ggcacttctt tcatattcta catcgccaat accgcttctt 2690221 gcattcacaa cccgggcggc ggcaaagaaa taatcggaca gacgattgag ataacgcagc 2690281 actgtttcat gaatctcctc cgatttcatc agcgccacca ctcttcgttc tgcccgcctt 2690341 gtaatggtgc gtgcgatatg gagaagcgaa gcacactttg atccgcctgg aagaataaat 2690401 ttcttcagtt ccggcgcttc tgctgtatag gcatcaatgc gcgtttctaa aaaggaaaca 2690461 gattcttccg ttagtttata gtcttttctt tctgtgacga ttgccagatc gcctccgcag 2690521 tcaaacagct catgctggat ggtcagcagc tcggctgtca gatcttcaaa gccgggctgc 2690581 ccggaaagct ctgccaaagc aagcccgata aagctgttaa gctcgtcaat cgtgccgtag 2690641 ctttcgacgc gtaggctgtc cttgtccgtt ctgcccccga ctaagcccgt ttgtccctta 2690701 tcgcctgttt ttgtatatag tttcataccc tgaatctcct ttacagactt attcaaacaa 2690761 ctcagcagcc tcttttatac attcagctgt ccctttcttt atcaattggt tcagccgctg 2690821 ttctatgttt tctgattgct gagtttgagt cgcggcgatg agaatatcac ctgtgcctcc 2690881 tccgtctccc agcactttcg tccgttctgc ttcggcagcc ataagagctt tgatgaagaa 2690941 ttgatctgcc gcatagccgt taatcaaaat ccaaatcgaa aagccggtct gaacgcatat 2691001 gaaaacggat aactctccgt cttcatatgt tcgatacacg aaacggtcaa gtctttctga 2691061 agaagccatc gcacacgtct cctgcagttg aaaaccgctt tctgaaagac aggccgtaag 2691121 tccttctatc ggatctggct gatctggcag ccgtttatgg atcagcgtcc tgctccacga 2691181 aaaccctgca ccgataggcg tggaggacaa tgttcgaagc gggatttccg tttgcagaag 2691241 aatgtcatca cgccccgctt ggagcaatgc ttcaaatggg atagactgcc gcttcacgct 2691301 atctttttca ggctgaatca caatcatcgg tttaggtgag ctttgatgaa ccaaggcggt 2691361 gacatctgta tcgtacaccg cctttatgct ttgttctgta acagcatatt ccggtttttg 2691421 cttaggcccg gcggtaccgt ttttcataaa catgagccca tcacagtaca ggcttgcggt 2691481 gttcagatca tgaaaaacgc tgacagctgc caatccgctt tctctcgtca ggcgtttgat 2691541 cagatcaagc aggtcttttt gataagccag atcgagaaaa ttagtcggct cgtccaaaaa 2691601 taaaatacgc ggctgctgcg ccaaagcttg tgccaaatac acccgctgct gttcccctcc 2691661 gcttagttcg cgaatcggct tttgcgcaaa atcggccact cctgtttgct ccattgcttc 2691721 ctgtacaatg gcttcaccct tttcagtctg ctgtctgaac agccccgttt ggaatggata 2691781 tctgccaaag gctacagttt cttcgacagt aaaggtgaag gcttgatcca ttttttgcgg 2691841 caggacagcc atgatttgcg ccagttcctt cggtttatag tccgccagca gttttccggc 2691901 cagataaacc ctgcctttct tggccggcag cgtacctgtc agcaagtgca aaagcgtggt 2691961 ttttccgctt ccattagggc cgagaattcc aagaaattct cccttctcca ctgttaagct 2692021 gacattgttg attaggcggc tgtcgccgta tcctcccgac agcccttctg ccttcatcat 2692081 aagcttctcc ccccgcgatg ctgccgaatt aaaataagag cgaacacagg cgctcccgcc 2692141 aaggacgtaa tgatcccgat cggcagttca atcggctcaa tgatggttct ggaaagcaga 2692201 tcggctaaaa caagaaaccc tgccccaagc aaggcggaca acggcagtaa atgccgatgg 2692261 tccgttcccc acaaaagcct tgtgatatgc ggaatcacaa ggccgacaaa gccaatcgta 2692321 cccgatactg ccacagcgct tcccgtcaaa agagatccgg ctattaaaat catcatcttc 2692381 ctctgctgaa cgctgactcc aagaagcttt gctttatctt ctccatatgt catcacgttc 2692441 agttcccttc cgtttataat caataaaatg gttcccaaaa gaaaaaacgg gagaaacaaa 2692501 ataacatagc tccagcccct cattgagacg ctgccaagca gccaatgcac aatcggaagc 2692561 aggttgtctc ctgtcaaggc gatgataaga gaaataaatg cgcctaaaaa agagttggtg 2692621 atgacaccgg tcaaaatgag ggtggaaaca gacatcgaag catgaacgag gcggctgaag 2692681 aaaaggaccg ccgccatcgt ggccagtgcc gcggctacac tcaaaaccgg gagtgtaaac 2692741 cctccgatga caggaaggtg caaacctaag aacagagtca caacagctcc gactgaagca 2692801 ccggatgaca cacctagcgt atagggatca gcaagcggat ttttcaacaa tccttgaaaa 2692861 gcggcccctg caatagaaag agccgccccc acaagggcgg ccagcacaac tctcggcagt 2692921 ctgatattca tcataatatt agtgtacatc ggatcatcag aaccgataga gccgccgaaa 2692981 ccttgatgcc aaaagacacg aaaaacagcg ggaataggaa tatgcaggct gccgcaagaa 2693041 attcctaaga tgatgctcac ggctaaaaat gagaaaccaa tgatatatgc ggcataacga 2693101 ttattcctta aacgtatccg ggtaaatgct ttccgcaagt tcttcgaccc cttcgatcag 2693161 acggggaccg gaacgtgtca caagatcagg gtccacatca tatacacgat gatgtttcac 2693221 agcattgatt tcgctccagc catcgcgttt ttccacagct ttcgctttca caccgtccgt 2693281 tgtaacaatt gcatcaggat tgagttttac gatcgcctcg tctgtcattt gcacccatcc 2693341 tgtctgatcc gcagctgcgt ttttagcatg gatgacattt agcatttcat tcataaacgt 2693401 atcttttccg gttgtataaa tgtcaggatc aggagaaacc tcgataaata cgcttttctc 2693461 ctcgtctttt gaaatggttt tcgctttttc ttgaatatcc tttagatctg atttcatgct 2693521 tttcacgagc tgatcggctt ttttctccgc cccgccagct tctccgatca tttcgattga 2693581 tttgtacacc tcggagaatg attgtgcatc attgacagtc agcactgtaa tgcccgcgtc 2693641 cttcagctgt ttgatggcat ccgctgatgc tgacatggaa gactcatggg ccagaacgag 2693701 atctggtttt agagaaatga ctttttcaac gtttacattc atatctccga ctttctcaac 2693761 ctttttgact tcctttggat aggtatcgtt tgtggtgaca ccgaccactt tgtcaccaag 2693821 gccgagtgcg tatgtaattt ctgtgttgct cggcattaat gaaacaatct tttttggctc 2693881 ttttttgatg gttacatctt ggtttgacgc atcatcaatg gtgacaggga acacttctgt 2693941 tttttgtttt gcctttgaat ccttctgatc cgcaggattg ccgcagcctg ccagcataac 2694001 agcagccaac agaagcgcag cccatatccc ggctcgtttt ttcataatct tttcctccta 2694061 aacgaactaa aaaagcatct ctacgacggt aaagatgctg taaacaacac aaaaaagcct 2694121 attgtttaca catcatctgt cctcgcagaa ttcgtgctga tcaaacaggc aggtatcctg 2694181 gctcttggcg cttggccaat tacagtggcg ggaccgcacc ggcttttacc ggtttccctt 2694241 ttaagccggc tgttgttcac ggaccggcac ctatttgaca ttcgtatccg tttttcggag 2694301 taattatact atatgactga caggcttgta tatgtgtcct gaatgacttt tccccatatt 2694361 gtgtatggaa gcaaaatcct cgtaaacact aaatttgatc ttgtatactt aataccatca 2694421 tctatcaaaa ggaatgattc ttatggattt acagctaaaa gaaaaactcg tcttaatcac 2694481 cggctcgacg tccggtatcg ggaaagccgc cgcaaaaagc tttctgcaag agggtgcggc 2694541 agtcattgtc aacggacgca aacaggagac tgtcgatcgc accattgaag agctttctgg 2694601 ctatggaaca gtgcacggtg ctgctgccga tttgtcaaaa acagatgaag cagcggcttt 2694661 tatcgaaaaa gtaaatgaaa tcggtgatat cgatatcctt gtcaacaacc ttggtttctt 2694721 cgaggtaaaa gacttcgccg atgtgacaga tgaagagtgg aatcaatatt tcgaagtgaa 2694781 cgtgatgagc gccgttcgga caagccgtca cttccttcca aaaatgcttg ccaaaaacag 2694841 cggccgcatt ttaaatattg caagtgaagc aggcgtcaaa ccgctgccaa cgatgattcc 2694901 atactcaatg acaaaaacgg cactgatcag cctttcaaga ggaatggctg aaatgacaaa 2694961 aggcacaaat gtgacggtca actcagtgct cccgggacct acttggacag agggcgtggc 2695021 ctcctatatg gaaggcgccg cacaagcagc cggacaggat acagatacat ttatcaaaga 2695081 ctatttcaag gtcaatgagc caacctcact tattcagcga tacgcgacag cagaagaagt 2695141 cgccaacaca atcgtattcc tcgcgtctga cgccgcatcc gccattaacg gcacggcaca 2695201 gcgtgtggaa ggcggcatta tccgttctct gtagtataaa aaaacgcatc cgtgtttcgg 2695261 atgcgttttt tttatacgtc tccagcaaat ggtaccggct gatatccgcc tgtttccagt 2695321 tgtgctgaaa acaaccctcc agcgtgaggc tgctcgtatc tctctttttc tgtcatttgt 2695381 tctgttgccg ttgtaatgta aagggttttt aagtctctgc cgccgaacgc gcagcacgtg 2695441 acatatttag ccggcacgct gattgaattg atttcttttt tctgaaacgg gtcaatgtga 2695501 acaacgcggc tgccgccaaa cagcgccacc cacagcatgc cattttggtc aattgtcatg 2695561 ccgtccggca atccgtctga ctgatcaaaa cgatagacag gttctggatt cgaaacatct 2695621 ccgctttgag gatcatagct gtaacgtaca atctcctggg tcggcgtgtc gatgtaatac 2695681 atcaaattcc gctcgcggtc ccaatccaaa ccgtttgagg tggagacttg atccttgatt 2695741 ttgacaagac tgccgtctag attcaaacgg tacagcgacg cctgtttttg ctcgccttcc 2695801 atgctcgtcg tccccgccca aagccttccg tacgggtcac atttagcatc attaaatctc 2695861 aggctctcat gcatgtcctt cggctgttta attttttcca agctgtcatc ccgaagatga 2695921 tacaggtaaa acccgtcctt catcgtcata atcagttcat cctttgaata tttcgcaagc 2695981 gccgtcacaa aggatttgaa tttgattgat cggttgattt tttcttcagg gtcaaagatg 2696041 tggagctcgc tccccaggat atcaacccaa tataagcggc cgttctcttc atcccataac 2696101 gggccttcac caatcactgc ccgagtgtct gcttccaata ctgcatccat gtgttacacc 2696161 tctttagctt cagtctatat attgttattc ccggcaaaga ggtgtccaaa ccacttgatg 2696221 tttattgttt tttaaaaagg atggtaatga ccgttccaat gttcgttctg ctgttcacat 2696281 ggatcgttcc gttatgcaga tggacaagct ccttggcaat cgcgagcccg agacccgttc 2696341 cggcagttga atcttttgtg ttcgtccctc tgtagtagcg gttaaacaaa tgggtgatcg 2696401 tttcttcatc cattcctttc ccattgtcct tcacttttaa agaaatatga ttttttgttt 2696461 gctccagaat gacttgaatc tctgttcctt tgccgttgtg cttcacggca ttcccaagga 2696521 ggttttctaa tatgcgcctg aaccacgctt catcaagggc aaattcaata tgctcttctt 2696581 tggatacaaa cgagatatca tagccttcag aaaacggatt tttcttaaaa tcctcaatga 2696641 catttttaaa aaacgggata aggctagtga gctttctctc aataggaaga gcatcatttt 2696701 tcaggcgata cgttaaattt aagtcttcaa tcagcttaga catgtattca gatttttctc 2696761 tgacaacctg ccccatttct ttcacttctt ccggcgacca gtcatactgc ttcgactcga 2696821 gcatcatgct gtagccgtaa atgctgctga gcggtgtttt taagtcatgt gacaaaccgg 2696881 caatccattc ttcccttgtc gcctggattt tttctctgtt tcttttatcc cttctcagcg 2696941 tttcagtcag ctgatccatt gattcaaata tctcaccgaa gaagcggtac ggctgtttga 2697001 tttttccctt tttatttttg ctgacaggac ggccttcccg gtttctgggc tcctcaagct 2697061 tcccttttga cagattgacc agccatctaa tcgtgtgaaa aatcggcagc ccgaatcgga 2697121 acatatacca aacggtcatc caaatgatat acatgaacaa aacggccatc acgagaaaca 2697181 tcgcttttaa tacaaccttc aggaatgatt tgttaaactc ctgatcggtt acatagactg 2697241 ggttcggcac cgtagcgacc atccatctgt ctttattgag gatcttaacg gaaatttccc 2697301 gcttatagtt ccaaggctta gagctgtatt taagcagctc cagctggttc atcgtttttc 2697361 tctcgctttt tgtgctgttg atgctgtcga gaatctttcc attgctgtct aacaggtaaa 2697421 tggcgccttt tttccgttta atatagtcga tggtactaga cttatagtgc gctagtgagt 2697481 ctatcttttg ttcacgcttt tcaacggaag tcaggagctg ttcacttttt gatttccagc 2697541 cggacaatag aagatacgac ttatcttcaa tattgatggc ccaataattc agtttatagt 2697601 tatgaagctt tttggtttta taaatagaca aaagctcttt cttggtatag gtgcccggca 2697661 cgtcttttgg cacgccgtag gaataatcag tgtttccttc cgaatcaatg atttgcatcc 2697721 agccgtgctg tttatcaaca gatttcttca ggaaattatc cacttcccat gtcccgtctt 2697781 cgtttacatc gagatatgcc tcaagtgtgt cggtcgttgc tttcgtcagc cctgaattgg 2697841 attccgcatc gctaaaacgg gcgtctaaat agaaaaacga tgcaacaagc ataaccgtaa 2697901 gcagcaggat cacaatcagc atctggccga aaaagtgaaa caaaaacttc catcttaacc 2697961 tcatgaccgc ttgccttcag gatttgggat aaaacgatag ccgagacctc gaacggttac 2698021 aatatactcc ggattgctcg gatcgcgctc aatcttctcc ctaagcttgc gaatatgaac 2698081 catgacggtg ttgttgtcac cgtaggaagg atagccccat actttttcat atatttgatc 2698141 tttggaaagc accacgttag ggtgttcaca aaaatactgc aaaagctgca gaagctgggc 2698201 tgaacaggca acggcttccc cgcctacgat caactcggca ttttgcggag aaaaagtaaa 2698261 gtaatcatat gtgtaggttt gatttgaact cgtttctttc gattgatatg tacgcttgag 2698321 atgcgctctg atccgcgccg ctaattccag cggattaaat ggttttgtga tatagtcatc 2698381 agctccaacc gcaaagcccg ataatttgtc cgcgtcggat gatcttgccg tcaggaaaaa 2698441 aatcggagcg tctgaatact ctctgatcaa tgtgcaggct tcaaaaccgg acattccgcc 2698501 catcatgaca tccagcacaa tcaagtcaac cttattggcc ttcacaacgg gaatcgcttc 2698561 ttctgcgctt gccgcatcca gtatatttcg ataaccttct ttttcgagaa cgcgtttgat 2698621 catgtccaca atcgctttct catcgtctac gattaaaatt gacgcatttt ccacttttat 2698681 gttcctttct gtcactgttt ttttcatctt atcattatat cgtttattta tggtacattt 2698741 ttgaatacat tggagccttg gcaaatcaaa acagcaaaaa aggagcaaac aagcgctccc 2698801 ttttgatgtt ttttcatatg aaaatattat gagttctcat ctaccatgta caaaataaac 2698861 tcccaaaacc ccggtacatc ctgacataaa agcatatcag ccttttcaaa cattttgatc 2698921 ttcagctctt gctctaaatc ttctctttct tgataggacg tattgctgag tttttttctg 2698981 atcatcggtg aaaagcatgc aatcaggtgc tcaatgtcat aagtctcgtc tttttgtttc 2699041 tttttttgtt caaactggcc gtccacagct tacttttccc cctttttttg cgccgctaac 2699101 tgctttctga tattctccag ccccttttta tgaatgttgg agatgttttg tcgggactcc 2699161 cctaatgaat ctgcaatctc ctgcatcgtg gcaccgtgaa gatagacttt cgtcagcaca 2699221 cttttttgtt tgtcagtcag cttctggatc gcttggtaga gctggtaatc ctgtacatgc 2699281 tggctcaaat catcctgcct gtctaaaaat tcttcaaatg catcgctacc tgtttcggaa 2699341 gaaagccgat ctcccgcctc cggatgatca accgtcagtg gataccgttt ttggtttttg 2699401 cgaacccgct tatcaaaatc aatagaaaag atgcgaatca ttgaattcat atacttgacg 2699461 atgcggattt ctttataaaa ttgcttaaat agctcgtcca atgatcttgc atctttttcg 2699521 ttagggcttt ccattacgtt tttgaacaaa cggtaatgct gaggattgct caaaaaatgc 2699581 ttcacgatgg gatgcttcat tatctcctta cattttgacc gtaaaagact ttgatagtcc 2699641 atcaaaccgc ctccctacta aattaaatga aggaaagcaa aaaaaagtaa actactactt 2699701 tccgcctagt gtcttccaaa atactttgca gcagtttacg ttttatcggt tttcctcact 2699761 tacatacatg actgcagaaa aagaagggag gtattttcct atggatcagg tttttataga 2699821 ggaagtcgta aaacagatcg gcaatttggg gtttcccgcg ctgattgcaa tgtatctgct 2699881 gacccgattc gaaaagaagt ttgatcaact aatagaacta atgacagaac tgaaagatca 2699941 tgcaaaaaaa taatttttca atcgaagttg acttttcact ggtttttttc acttaacaaa 2700001 acagaaggga aaacgaaagg cctttcacct tctctttctg ctatcacatt taaatgtaag 2700061 gaggaaacat ttcatgaaaa aacaaaatga cattccgcag ccaattagag gagacaaagg 2700121 agcaacggta aaaatcccgc gcaatattga aagagaccgg caaaaccctg atatgctcgt 2700181 tccgcctgaa accgatcatg gcaccgtcag caatatgaag ttttcattct ctgatactca 2700241 taaccgatta gaaaaaggcg gatatgcccg ggaagtgaca gtacgtgaat tgccgatttc 2700301 agaaaacctt gcatccgtaa atatgcggct gaagccaggc gcgattcgcg agcttcactg 2700361 gcataaagaa gctgaatggg cttatatgat ttacggaagt gcaagagtca caattgtaga 2700421 tgaaaaaggg cgcagcttta ttgacgatgt aggtgaagga gacctttggt acttcccgtc 2700481 aggcctgccg cactccatcc aagcgctgga ggagggagct gagttcctgc tcgtgtttga 2700541 cgatggatca ttctctgaaa acagcacgtt ccagctgaca gattggctgg cccacactcc 2700601 aaaagaagtc attgctgcga acttcggcgt gacaaaagaa gagatttcca atttgcctgg 2700661 caaagaaaaa tatatatttg aaaaccaact tcctggcagt ttaaaagatg atattgtgga 2700721 agggccgaat ggcgaagtgc cttatccatt tacttaccgc cttcttgaac aagagccgat 2700781 cgaatctgag ggaggaaaag tatacattgc agattcgaca aacttcaaag tgtctaaaac 2700841 catcgcatca gcgctcgtaa cagtagaacc cggcgccatg agagaactgc actggcaccc 2700901 gaatacccac gaatggcaat actacatctc cggtaaagct agaatgaccg tttttgcatc 2700961 tgacggccat gccagaacgt ttaattacca agccggtgat gtcggatatg taccatttgc 2701021 aatgggtcat tacgttgaaa acatcgggga tgaaccgctt gtctttttag aaatcttcaa 2701081 agacgaccat tatgctgatg tatctttaaa ccaatggctt gccatgcttc ctgaaacatt 2701141 tgttcaagcg caccttgact tgggcaaaga ctttactgat gtgctttcaa aagaaaagca 2701201 cccagtagtg aaaaagaaat gcagtaaata aaagacttgc ggcttgcaga gagcactcgt 2701261 tctctgcaag ccttcataag gagctgaacc agtgaaacat caaaaccctt caaaacgctt 2701321 attgcggctc tccataaagt acttgctggc cgcagcagca gtggtgttga cctattttgc 2701381 tgtcatctat atattgtttt ctttagcggg aacgagctac cgctcagcag ctcatgtcct 2701441 gctttttgcc gtggtattcc ttgttctcgg attatgcttt gaaccatttg aacggctgat 2701501 gatacatagc tttacatttt tcaagacagg aaaacgtcta ttcattctcc ttgctggcat 2701561 cgtacagctg ctgtttttgt ggatgactgc tcatacaaca gaccaattga tcagcgacat 2701621 ctggctgtcc accacagaag aaatgattgt cgcagccgtt tttttgattt tagacaaatg 2701681 caactcggct cttcccagct aaaaaaagaa cgcattccaa ttggatgcgt tctttttatt 2701741 catagcgaag cgcgtctaca ggctgaagct tcgaagcctt gatagacgga agcaagccga 2701801 agataatgcc gactgccatt gaaaagatga gtgctccgac aacagctgga atggagacga 2701861 taaaaggcat cggaaaaatg accgtcagca gcttggcgat gccgaagccc gccagcacac 2701921 cgagtattcc gccaatgctt gtcagcacga cagcctcggt taaaaattga aataaaatca 2701981 cacgccgctt agcaccgagc gctttcttaa ttccgatttc cctcgtgcgc tccgttacgg 2702041 aaacgagcat aatgttcatg acgccgatac cgcccaccaa aagtgaaata ctggcgatac 2702101 cgccaagcag caatgcaaat gactgattaa aggactccac ttcctgcgcg atctcctgaa 2702161 gatccattac actgtactct gctttttcca gctcagcttc tgacagtccc tgatttaaaa 2702221 gatctgcagc cattacaccc gcttcttgga tatgctcaga agaatcagcc tgcacggcaa 2702281 tctgcgttgg cgcgtcaaat ccttcaataa gcggccacac ttttttcggc acgtacaaaa 2702341 ccgggttcgc atagtcgcct tcaaacatgc tttcctgttg atttttttct ttaaaaacac 2702401 ccacgacctt aaacggcaca ccattcatct caatgctttt atgcagagct tctccgtctg 2702461 gaaacagttc atctctgaca gcttcattga tcatcactac ttggtgtgtg ctgtttaaat 2702521 cgttttccgt cagctttctc ccttcggtta ttcggattgg aaacatgtcg aagtaatcat 2702581 cgtccactcc atacacttgg ggatacgaaa cgttagttaa atgaaaaacg ctcgcgcctt 2702641 ctgacaagta atataaggat aatcctttga ccatcggatc tgatttgatc gcctttactg 2702701 tttcttccgc tacaggcggc gcggacgcat acgacacctg agggccgccg ctctcctctt 2702761 ctccgccaga cggctggtag acaacattga tggcgttgtt tcccatgccg atcatacttt 2702821 gctttaactg ctcactttgg cccttcagca ttgaaacaat cgcgatgatt gccgctatgc 2702881 cgataatgac gccaagcatt gtcagaatcg atcttaattt atgagagaaa atggattgaa 2702941 aggagattcg aatatgttca agcatggctg atatcccctc tctcatctaa taccaactct 2703001 ccgtctctga taaaaacggt tctgtcagct tttttggcga cgtccgggtc gtgggttatc 2703061 ataataatgg tcttgccttc ccgatgcagt tcagaaaaca gtgccaaaat ttgttcactt 2703121 gatttggtat caagcgcccc ggtcggttca tcagctaaaa taaacctcgg ctgattgaca 2703181 agggccctcg ctatcgccac ccgctgcttt tggccgccgg acagcttagg cggtttgtag 2703241 gagaccctgt cttttaatcc gactttttcc agcgcttcat atgcccgttg ccttctctct 2703301 tttttcttca ctttattgta gatcatcggc agctcgacat tttgcagcgc ggtgagacgc 2703361 ggcagcaaat gaaaagtttg aaacacaaac ccgattgatt cattgcgaat ttcggctaaa 2703421 gccccgtctt tccctttcaa tatatcgatc tggtcaagcg tataggttcc tgaggttggc 2703481 ctgtccaaac agccgataat attcattaac gttgactttc cagaaccgga aggccccata 2703541 atagctaaaa actcccccgc ctgaacggtc agattgatat gtttcaagat tggaacttct 2703601 tcttttccca gcttgtacga cttcgaaata ttattcagtg tcagcattga ctgtaacctg 2703661 ctttccttcc ttgaccgcgg gatcaggata gatcacataa tcttccggcg tcaggccgct 2703721 cttaatttcc accatgtcat tttcatcagt ctctccgatt tcaacaggct gcttaaccgc 2703781 tttgtgattc tcatcagctt tccatacgta cggttcgccg tcatcctgaa tgaccatgtc 2703841 ggacggcagc ttgatcgtgt ccgcatcagc attatcactc atcacttcga tgttgacatg 2703901 atagccgact tcaagacctt tatggctgtc taataaaatg gtgaaaggat agttagagga 2703961 ctggggattc atttcttcat cagcaaagct ttctgattct tcaccctcgc ctgctcccgc 2704021 tggaagcttg ccgatcgagg tgacctttcc tttccactcg ccctcaccgc ctgttttcag 2704081 cgtgaccctg actttgctgc cttttttgat cgtgtccatt aacagctcat tgatttggct 2704141 tttgaccaga tatttgcctg tcgaaacaat ctggatatac gggcctgctg cctggtcgcc 2704201 tgttgcaccg tcagcgatat cctgattgac gctttgaacg attccgtcat gcttgcttgt 2704261 aatgacattg gaacctttgt ttttcgtcag gccagccagt tctttttgat gctgcttcag 2704321 ttcaagctgg cttgttttca aatcgaaatt ggtttgatca agttcatctt gaagctggtt 2704381 tttctcttct tttcctgcaa ctttcagctt tttttccgtt tccgttattg atttttgcaa 2704441 acggttgatt tgcagatttg tcatttcaat ttgcaaattg gcttgctcca cttcatcaga 2704501 atgatcctcg ccctcatact caaaaagctt atcgcccttt ttaacctgat cgccttcttt 2704561 gacgtatgtt tttttaatgc tgcctttttc tgaatctatg tatactttct gctgtttctc 2704621 aggttcaacc tttccagaaa acgtttggcc tgattctgaa tctcctccca tgtataccgc 2704681 gaccgattca gcatagggct ccgatgatac ggcaacttgg ttcatgtgag taaaaaagta 2704741 aaaaccgcca gcgccgatcc cagccaatac aagcacaccg gcacatatcg caccgccaat 2704801 aagccatttt ttcttcttgg acacaacgat ctcctctttc tgtaaactat gtaatatttt 2704861 cgaaacattc taaccaatat tatctattaa ttcaaaaaga cttgcaatcc ttttattgaa 2704921 atgacggaat caaatagaaa aattgtattt tcaaagccga ataaaaaaaa tcccggcttc 2704981 aaaccgggat tttttcatac agtaactagc tctttttcat ttttaatcaa gtcatatgtc 2705041 aagcatacag gtttatttgt acggggatca gtcacgattt cggcatcaat ctgaaatacc 2705101 tgcttcaaaa tgtctggtgt catgacctcc agagcagttc cttccttgat gaccgtgcct 2705161 tttttgagcg cgatcatata atgagaaaaa cgagctgcat ggttaagatc atgaatgacc 2705221 attaaaatcg tccgcccttg ctctttgttg agtctgtcaa gcagctgcag aatttcaagc 2705281 tgatgtgcaa gatcaagata cgttgtaggt tcatccagca gaagcagttc cgtcccttgc 2705341 gcaagcgcca tggcaatcca cacacgttga cgctgtccgc ctgacaatgc ctcaatcggc 2705401 cgttcagcat attcagccat gcctgtttct tcaagcgccc atttgataat ccggcggtct 2705461 tcgtcattta atctgccgaa tcctgattga tgcggaaacc tgccgtacga caccaattcg 2705521 tgcactgtta ggccgctcgg cgcttcaggt gtctgtggaa gaatcgccat atcttttgca 2705581 atgtcctttg tagacatttt atgaatcgct ttgccgttta aatagacggc acctgcatgt 2705641 gaacgcataa ttctggacat tgtttttaaa atcgttgatt tcccgcagcc gttcgggcca 2705701 attaaggtgg taattttccc tttaggaatc gatatattta aatcctctac aatcaccctg 2705761 tcgccataac cgattccaag ctgttccgtt gataatgaat tcatattcgg ccccctcctc 2705821 taattcgctt tcatcaataa ataaataaag taaggcgcac ctagcacgga aatgacaagt 2705881 ccgaccggaa tttctgatgg tgccaataca tttctcgcca gcgtatcagc aagcaaaaac 2705941 aggaatgagc cgatgaaggc ggagaccggt atcagcgtct ggtgacgtgg accggtcagc 2706001 cttctagcca catgcggcgc gatcaatccg agaaacgcaa tgccccccgc agctgccacg 2706061 catgaagcgg caagagtgac cgctgccaga agaagaatcc gtctttcctt ttcaacagcg 2706121 gtgcccagcc cggtcgccaa ttggtctccg agctgcataa tgttcaaata gcgtgcctta 2706181 tataaagtaa acagaagcaa gatcacaatc caagggagaa tcgcccagat catattccag 2706241 ttcgcccccc atattgagcc ggatatccaa accgcggctt gcataaaatc atgagggtcc 2706301 atcttgagct gaaaaatcag caacagggcg ttgaatccgg cattcacccc tatgccgact 2706361 aaaatcagcc gaatcggtgt cacgcctttt ttccatgcca gaatataaat gagaaacgca 2706421 gcgaggattg ctcctgccaa agcactgaac ggcagcataa atgttccgaa aaagctaaga 2706481 tctgaagctg acccttgaaa aaagtatata aaaagcacta cagcaagtga accgccggcg 2706541 ttaattccga gaataccagg ctcggcaagt tcattttgag acacgctttg caaaatggct 2706601 ccagctacgg agatccctgc tccaacaagc aaagaaagga tgatccgggg cagcctgaac 2706661 tcaaataaga caagttcatc acgcgccgtt ccttggccga aaaagacctg aagcgtttta 2706721 agcggtgcaa ttttgataac gcccaaattg agactgataa aaaagaccac cacgataagc 2706781 aaaaaggtca cagccattac aatgagcggt ttgtttgttt ttgttttcat tacagccctc 2706841 tcctttcacg acgtgccaaa taaaagaaaa agggaacgcc gataagagaa gtcagcgcgc 2706901 cgacaggcgt ttcaaagggc gcatttacga gtctggccgc tatgtcagca aaaacaagca 2706961 aaacagcacc gagcaccgcc gagcaaggaa tgatccaccg ataatccaca ccgaccaaaa 2707021 aacgggtaat atgcggaatg atcagcccga taaatgcaat ggtgccggca atggaaaccg 2707081 cagctccggt cagaattact acaataagca tgccaaccag tttcaccgct gatgtatatt 2707141 gtccaagccc ttttgccaga tcgtcaccga gacttaacac tgtaacagac cgggcgatga 2707201 aaaacgcgag cgttaaaccg acagcccctg caataagcaa aagctggacc cccgaccatt 2707261 tcacacccgc taccccgcct gcgtaccaaa agctgatatc ctgagcgaca tcaaagcgga 2707321 ttgcaatggc agttgaaatg ccggtaaaga aataagtaac tgccgtaccc gccagagcaa 2707381 gctttacagg cgtaagtccg ccccttgaaa acatgcctat gcccattacc gtcgatgccc 2707441 ccagccccgc tcccgcaaag gaccatagca caagccccat tgcagaaagt ccgggaaaaa 2707501 aggcaaacgc aatcgaaacc gcaaacgcag agcctgatgt cacacccata atcgaaggct 2707561 ctgccaaagg gtttctcgtc atcccctgca tgattgctcc cgacactgcc aacaatgcgc 2707621 ctacaagcgc ggcagccgcc gttctcggaa gccgaagatc atgtataatt tggtgagatg 2707681 tctttgtcgg ctgataatga aaaatggcct cccatacagt gcgcaaatga atatccgctg 2707741 cacctaggga tatggataaa aatgcgccaa ggcaaagcag gcatagacct gcgataagga 2707801 cgatgaccgc gccatatgtc cttgacgtcc attggatttc ttctgatgca gtccgtatat 2707861 ttttatgttg actcaactgc cgtacttcct ttctgttact gataatgatt atcaattgct 2707921 gtttcagtat atcacttttt tcagctgatt taatagagtg ttttgaacaa aaatgaaaat 2707981 gcatttgcaa aaatatcgtg tcaaccggca cttgcagtgg tataatcaca gatgataatg 2708041 attctctttt tcatctatct tttagaaaga aggtatgaga tatgacccat atatacaaga 2708101 aactcggagc cgcgtttttt gccctgttat tgattgcagc gctggcagcc tgcgggaata 2708161 actcagaaag caaaggttct gcctctgatt caaaaggcgc agaaaccttt acatacaagg 2708221 ctgaaaacgg aaatgtaaaa atcccgaagc atcctaaacg ggtggttgtc atggcagacg 2708281 gctattacgg ctacttcaaa acactcggca tcaacgttgt aggtgcgcct gagaatgtat 2708341 ttaaaaaccc ttactacaaa ggaaaaacca acggcgtcga aaacatcgga gacggcactt 2708401 cggttgaaaa ggtcattgat ttgaaccctg acctgattat cgtctggaca acacagggcg 2708461 ctgatattaa aaagcttgaa aaaattgcgc cgactgtcgc agtaaaatac gataagctcg 2708521 acaacatcga acagctgaaa gaatttgcaa aaatgacggg aactgaagat aaagctgaaa 2708581 aatggctggc caagtgggat aaaaaagttg cggccgctaa aacaaaaatc aaaaaagcgg 2708641 tcggtgacaa aaccatttcc attatgcaaa cgaacggaaa agacatttac gtatttggta 2708701 aagactttgg aagaggcgga agcatcattt acaaagacct cggcctgcag gctacaaagc 2708761 tgacaaaaga aaaagccatt gaccaggggc caggttatac aagtatttca ttagagaagc 2708821 tccctgactt cgccggagat tacattttcg cgggcccatg gcaatcaggc ggtgatgatg 2708881 gcggcgtttt tgaaagctcc atttggaaga acctgaatgc cgttaaaaat ggccatgtat 2708941 acaagatgga tccgatcgga ttctatttca cagacccgat ttcattagaa ggacaactgg 2709001 agtttattac ggaaagcttg actaaataaa caaaagagcc gcctgcccgc ggctcttttg 2709061 cttatttata aggaacggct caatttgaat catatcggat attttctttg agccattcat 2709121 attaagctgc atcctcatca cgatcagttt ttttatgctg gagagactga aaaacgtttt 2709181 ttgcatattt aacgaacgga ttcctaacag gagaaattgt gattttataa aaaagacacc 2709241 tgagcaaatc aggtgtcttt tcattatgct tgtttttctt tctggaactt gttactcaca 2709301 aatggataaa cgattaagcc gacaaagaat aaaccgatgc cgagtataaa tgtcgttaaa 2709361 tctgctgtgc ctgttacgat aacaaacacg gagtatgcac acgccagtat cgcgatcaat 2709421 ccgtctctta cacgggagcc tttcagctgg tcatacgttt cacctttgat gactaccttc 2709481 aagctgtaga ttgcagatac cagatacgga attaaatatg cgagtgtagc cgctgtcgtt 2709541 aaaaatgtaa atgcgtcact tattgtccgg gaaataaccg agaaaatgaa gacctgtgac 2709601 atgacgtttg taataatgag tgcaatgacc ggacttccct ttttattcgt ttttgcaaaa 2709661 aatgccggga aatctcctgc tttagcggct tggtatggca cctcagagcc aagcaaaatc 2709721 cagccgagca tcgttccgaa taaacaaagg atagccaaaa gcgccataat cacgcttccc 2709781 gcgtttccaa caatcgcata gagtacatca acaaatggtt tttcagagcc gacaagctta 2709841 tcatgcggca gaacacccat cgtaattaaa gtcacaataa tatatatgct caaggcaatc 2709901 agcaagccgg taattgtcgc acgtttcaca tcacgctgag agcgcgcacg gccggacagg 2709961 atcaccgcgg attcaattcc gacaaacgcc cacagtgtag aaatcgcagc gttatgaacc 2710021 tggccaccaa ttccaatgct tgtgccgttt tctccttgaa ccgggaaata aaaatgaccg 2710081 aataatgacg tttgaaacac aaacaaaccg gcaacgataa agaagacaaa acctaatact 2710141 ttagaaagcg ttgtgacaaa gtttaattta cttgcgccgt taatgctggc aacaagaatc 2710201 gcgtgcgttc cccataacaa gatcgtacat acggcaaacg tcagtaattg gccgagtgtc 2710261 acctcttgcc cgccgatcga aaacatctca cgtttatcaa ccaagatcgg gaagaacgaa 2710321 gtcaagtaac cggcgagact tgtgatgatc gccacgttac tgatccagct cgccacccag 2710381 tagccccaca ccattgtgaa accggcagcg ttgccttttt tcgggtcaga aaacagcgct 2710441 cttgcataac tttgcggtcc cgctgtcagt tcaggcttgc gaatggacaa gtgtccgaac 2710501 acaagtgcaa tcatcagcac gccggcacct gtcaaaagcc aggcggacgt agctccaaac 2710561 ggactcgcaa ttgaagcaag cgagctcggc aaggagaaaa ttcctgatcc aaccatattt 2710621 ccaacgacaa acgccgttaa taaccaaaaa ccccattttt ttgtctgttc cattccagta 2710681 cctccatgat tctttgtacg gaccagaccc cgagatcata taaacgcaaa aaaagcctga 2710741 acaaaagtcc atgcttaaag aaacacacac ccttgatctc cggatagccc tccgcgaaaa 2710801 agcacgcggc agtcctgcac ttattcagat acagtcccag catagagaag gatcggcttt 2710861 ctccacactt cggcgctgat gccttttaca catgtttaac agcccctgtc agcctagcat 2710921 gtgtgactca tcatccgcgc aacctctacc tcactgagaa agagtgagga tttaattatt 2710981 cagttactcc cagaaggtta tcaaagaaag gatgatctgt caaagggaac agatggaaaa 2711041 tacggataga gccaagccct atccgcatgt ggttatcgat tatttttctt tttttgcaca 2711101 gcttcttgaa gcggatcatc ttttagagct gaaccagcat cttcaagagc tccttggatt 2711161 acgttttttt ctttttcgga acgttttcct ttatctttat taaagaaacc cattcgtatc 2711221 acctctttta aaaaataggt acatgtttaa gatgcctttt tcctgaaaaa ttatgcggga 2711281 tattttttat cgtccaaagt cctgttgatc aaacatacat tctcttgata tatttgtaat 2711341 tcagagattt tttgcaaaag ataaaaggag aagcggcaaa tgacaggaaa aacacacatc 2711401 atgggaggca tcgcttcttg tacggcagcg gcttattatt atggatttga tccagtgctt 2711461 atggctgcgt caggcgcggt tggagcatta atacccgata tctgccacac acaaagcaaa 2711521 atcgggagaa aatttcctat tttatcgaaa gtggtcagct ccgtttttgg ccatcgcacc 2711581 tttacacaca gcctgctgtt tatgctcatc atgtttttta tcacttctac atacattcca 2711641 gataaaaaca tatcagccgg cctgatgatc ggaatggcga gccacttgat tcttgacgct 2711701 tggacggtga acggaatcaa attattattc ccttccacga tccgcgttcg gcttccatta 2711761 tatatgaaga caggcagttt ttctgagcag ctcgtgctag ccggcctgac ccttgcttca 2711821 tgttactact tttatatgct gtttcatggc cgcatgtttt aaacatgagt gctgagactt 2711881 gtctgaaccg gctgttttta gtaggtttta cttaagaagc atttcatgca gatgatcaag 2711941 aaaacgtgag gagtcatatt gatgaaagga accttttttc acaatcagcg gtttttatgt 2712001 ttttcgatct tatttatgtg gatcaaaacg tatgtgatat ataaactcgg ctttgatttg 2712061 caaatcgata ctctgttgga ggagctaatg ctgctggtca acccgctcag ctttattctt 2712121 cctttattcg ggatcggcct gtttctaaaa gaaaacaagc agcgggcctt tttgctgatt 2712181 gccaatttgg ttctgactgt tatcttgatc tctaatacga ttttttacgg cttttatatc 2712241 gattttatta ccatcccggt tttatttcag gccagcaaca tgagcgatat gggcagcagt 2712301 gtaaaagaac tgttccatcc tctgtttatc gccctgtttg tggatttggt ttttctgctg 2712361 ttgttcgcca gaaaaaccaa acacccacag acaaaagccg ctccccacac gatcaaacgg 2712421 tactatgcag cttcctgcgg aatgctttta tgcacactgg cacttgcaga agtacagcag 2712481 ccgaagcttt tggcacattc ttttgaccgg gaaatgctag tcaaaagcat cggcctgttt 2712541 cagttccata tttacgatac aatttctcag actgttaata tcagcgcgaa agcttttgcc 2712601 gatgaagaca gtataactgc cattaaaaac tacacagagg ctgattacag caagcctgat 2712661 caaagcaaat tcggtcttgc aaaggggcgc aatgtcatct ttgtaacact tgagtcgacc 2712721 caaagctttg ttctgaatga aaaagtaaat ggaaaagaaa ttaccccatt tatgaatgat 2712781 ctcataaaaa aaagctattc ctttgatcat ttctatcagc aaacagaaca aggcaaaaca 2712841 tcagattcag aatttatcgt cgctaactca ctgtatccct cccttagcgg cgccgtcttt 2712901 ttcacgaaaa gcgaccatca atttcatacg atgtataaat cgctgaagca gcacgattat 2712961 tattcagccg tctttcacgc taaccataaa acattttgga acagagatgt catgtacgat 2713021 acatttggca ttgaccgctt ttttgatgtt gatgattttc atgtcactcc cgggacatcg 2713081 acaagctggg gcttaaaaga caaagaattt ttagagcagt ccgccaaaaa gctgaaaagc 2713141 ctaccgcagc cgttctacag cagttttatc acgttaacga atcattttcc gtttgagatt 2713201 gatgaaaagg atcagctgat agatgaattc gattcaagca gtgatctgtt aaaccgctat 2713261 gtgaccacgg ttcgctatga ggatgaagca ttgaagcatt ttatcaaaaa actgaaggac 2713321 gaaggcttat acgaaaattc gatgatcgta tttatgggag atcattacgg catttctgaa 2713381 gcccataacg aggcaatggc tgagttttta gggaaagacg aaatcacacc gtatgacaac 2713441 gttcagctcc agcgggtgcc gtttatcata catatcccgg gaatcaccga tcaacagccg 2713501 gaaaccatcc ctgatgccgg gggacaggtc gacgtcaggc cgacgctgat gcatttgctc 2713561 ggcgttgaga caaaaggcga tatccaattc ggcaatgatt tgctgtcggg cgaccgcacc 2713621 ccattcgccg ttctgcgaaa cggcagcttt attacgaacg attatgtata cacaaagaac 2713681 acgtgctata gccaaaaaac aggtgaagtg ctggaagatc aggatgcgtg cctcccttac 2713741 aaggagaaag caaacgaaga actgtctctc tctgataaaa ttttaaatgg tgacctgctc 2713801 aggttttccg aatgaaaaaa tccctctatc aagagggatt ttttacgttt ccaatatcac 2713861 cttgccagtc agcttcgttt catagccgtt taaatgagac agattcgcct tgtagtcctc 2713921 agaattcaaa atctccttca cggctttgag caactgctca ttttttttca aaacaacgat 2713981 atcatattgt tcgtcgatga gcgggataaa atcaacactg cccatatgtg ccgcgtgctg 2714041 tgccccgatt cccgcgtcag cctgtccgct tgaaacttgt gaagcggcag cgtaatgatc 2714101 agtcacgata tcgccatatc ccactacatc agccggattc acaccaagca agccaagctg 2714161 ttcatcaagg agcacccttg cgccagaacc cttttccctg ttgatgatcc ggatatcggc 2714221 tcttttcaag tctttccagc cttgaatgtt tttcggattc cctttttgca catacagtcc 2714281 tgctttgcgg agaacgacat tgatgagaca aaacggttca cctgtcaaaa tccgttttac 2714341 ataaggcgcg ttatactggc ccgtttctgc atcgtacaaa tggaggctga caatgtcaca 2714401 cttgccttga tacatatcaa tcaggctgtt taagcttcct ttgtatttac ggagcggcgt 2714461 ctcctgaatg gcattctcca aatgcttgct gaggatatcc atcgaaatgt cctgtccgct 2714521 gatcatgaca tttggtctgc cgtccggctc agcctcctgc acctgtttcg gcgcttcttt 2714581 tgcagcgatg ggctgagaca ttctcatatt cgttttatat tgctttaaat cttcttcatc 2714641 cacacgcatc tgccttccga cacggtaagc aggcagcacg ccttttttaa tcaagtcata 2714701 aacggtcagc tttgatacct tcagcagacc tgcaacttct tctatcgtat aggaagaggt 2714761 ttcattcatc atcatcactc tcctatttta ttataccttt tcgccgaatg taaaaaaacc 2714821 cacataaacc aaacataatc agttataatt agttatatct aatgataagg ggtgcaatca 2714881 tgtttaagaa gtattctatt ttcatcgcag ccttaactgc ttttctgctt gtagcaggct 2714941 gttcttcaaa ccagtcttca acggacagcg agaaaaaagt aacgttaacc atctcagctg 2715001 ccgccagcgc gcaggatgca cttgaggaaa tccaaaaaaa ttatgaaaaa gatcatcaac 2715061 atataaccat ccaagataac tatggctcat ccggcgcctt gcaaaaacag atttctcaag 2715121 gagcaggagc agatctgttc ttctcagctg ctgaggataa atttaaaaag ctggtggatg 2715181 atggagatat cgcaaaaaaa gacagcactg aattagtcgg taatgaaatt gtgctggtcg 2715241 taccgaaaaa cggagattca cctgtgacaa gcttcagcaa tctggctgaa tcagaaaaaa 2715301 tcgctcttgg cactccggaa tccgtaccgg caggagctta tgggaaagaa tcactgacaa 2715361 agctgtcttt atgggacaaa gtgaaggata aaattgtgta tggaaaagac gttcgccaag 2715421 ttctttctta tgttgaaacc ggcaatgtag acgcaggtgt tgtttataaa acagatgccc 2715481 tagtctcgaa aaaggtcaac attgttgacg aggcaaaagc agatacacac agcccaattg 2715541 tctatccgtt aggaatcgta aaagatacaa aacaccgtaa ggaagcgaag gaattttacg 2715601 aatacctgca atctgatgaa gcaatgaaag tatttgagaa atatggcttt actgccgagt 2715661 agcataagcg cttcagaatt tttcacaccc gttgtgcttt cctttcaggt ggcggcagtt 2715721 gccggaattg ttgtcattat tctcggaaca cttgctggag catggatgtc acgggcatca 2715781 tttttcggaa aaacggcact cgaaacatgt tttatgcttc cgctcgttct tccgcctact 2715841 gttgtcggtt ttattctgat cgtcattttc ggaaagcaca gcttcatcgg acaagccatc 2715901 gagtggattt tccagcagcc tgtcattttc acctggtggg ccgctgtgat cgcctcggct 2715961 gttgtagcct ttccgcttat gtatcaatca gccaaaaccg gatttgctga cattgatccc 2716021 gatatacaag gtgcggcaat ggtagacggc gctagcagat ggaaagtgtt tatccatatc 2716081 tccgtcccgc ttgcctatcc ttcgttactg accggaagca tccttagcct tgcgcgggcg 2716141 ctcggagaat ttggcgcaac actcatgttt gcaggaaaca tccccggtgt tacgcaaaca 2716201 ctgccgacgg cgatatatgt cgcattggat tccggcaaca atacccttgc ttgggcgtgg 2716261 gtcgtctgta ttgttgtcat ttcctttttg atgctgtttt tcattcaaca gaaaaaaacg 2716321 cactaaaaaa actccccata acggggagtt ttttgattaa aacagaagct catcaggatt 2716381 tggaccgaca cgctcatctt tatttaatgc gtcaattttg tccatgtctt cttgagacaa 2716441 ttcgaaatca aaaatatcag cgttttcgat gatacggtgt tctttaatgg attttggaat 2716501 ggttacaact ccatgctgca gatcccagcg caaaatcact tgagccacag atttattgtg 2716561 tttttcagca atctgtgtca gtacttcgtt atccaaaagc tgtccctgca tgagcggaga 2716621 ccacgcttcc agctgaatgc cttgcccttt gcagtaatct cttaattctt tttgcgtcaa 2716681 gcgagggtga aattcaactt ggttcaccat cggtttgatt tcagcatctt tcaacagctc 2716741 ttctaaatga tgaacttgga aattgctgac gccgatcgcg cgaattttgc cgtctttgta 2716801 cagcttttca agcgcgcgcc atgtatcttt atatttatct ttgccaggcc aatggatcaa 2716861 atataaatct aagtaatcaa gctgcagtct ttctaggctt ttttcaaagg cagcaagcgt 2716921 tgtttcatag ccttgatctt cattccacac ttttgatgtg atgaagagct cttctcttgc 2716981 cacaccggat tctttaatcc cgatgccaac gccttcttca tttttgtaga tcgctgctgt 2717041 atcaatactg cgatagccat ttttaattgc cgctttcact gattcagtcg cttcattacc 2717101 attttctact ttaaaaacgc ccagaccgaa ccaaggcatt tcaactccgt tatgtaactt 2717161 tacagtatct tttaaacttg ttggcacttg aacctccacc ctttcactga aatgtaagcg 2717221 tctatattat ctcacattcc tctcagccga taccaataat acgcttaaga ccctcttttt 2717281 gcttcttttt tcacagcaca ggcaaatcca aacactattt ttttcctatt ttaacaatat 2717341 tgagattaca aatacattga gcagggtatg cgtgtagtgt aaccaaatga aaacaaagga 2717401 ggaaacaact tgaaacgtat tcgtatccca atgacacttg ctcttggtgc cgctttgaca 2717461 attgcccctt tgtcctttgc ttccgctgaa gaaaatcctg ctccgaagat gtcgcagaca 2717521 actactgctg gaacaactgc cgctgatgta ggtttaaacg tcaacctgga tgtacttgga 2717581 attgccaacc agatcgctga tgccatcaaa tccgcacaga atagggatgg ctttgtgaaa 2717641 aacctcatgg agtcttcctt ctacgcgtcc ggccaaaaat ataacgtcat ggtctttaat 2717701 ttaagccagg aatatgaaga tcatttgaac ggtgtgcaat tttacggctc agccgtttac 2717761 gacggcatta cgtatggcat ttgggtattt gaagatggaa cctttacaaa caaaggcgat 2717821 ggcggctgga tcaactgggc cttcagaggc tggttcgacc gggatggcag cactgtcgca 2717881 tttcatcgcc cttaatataa aaaaagctgg cgctctaacg ccagcttttt ttctgcattt 2717941 attcgccgcc ttcaagcatg gcggcttcga catcattaat gtattggcga agctcatggg 2718001 agatgtcccg ggaaatttcc ctctcttcga agagcgtttg aatttcattt ctgatcgcct 2718061 gcacagcctt cagcttcact tccagcttct gattttcaaa atgggcactt gattttaact 2718121 catgatggct gtgctccagc ctgaaaatta actgcttata gaatgtaatg acagataaaa 2718181 acacttcttt atgctcatcc gtcttatgtt tttccagata ttctatcgct gcttttgccg 2718241 ttttcactct tgttgcccgt atcaatcccg cttcatttaa aatcgacatc tccggctttt 2718301 tatgttcacc gaagaaaatc caatacatca gcctcttgag ccttgttttt gataacccga 2718361 ctttaaacgg gttggcatac aaaatttcca actcgttaaa tcgttcttgc agcacatttg 2718421 ctgtttcttc cgggatgtct ccccgctcca gcattttcat cagcgcctct tgctcagcct 2718481 taaccccctg cgcacggact tttcgctcgt gcttcttaat gcgattagat gatgtatact 2718541 gctgaaaacg aagatttttc attttctcat tgtattcagc tatcaccgca agagaggccg 2718601 ttttgtttgt ctcattcatg tcctctttaa tcgtttgaag ggctgttttg atcaacttgc 2718661 gtctcgccgt cagcagcttc ttatttcgtt cctcgtcctc ttcttctttt tcagtcagaa 2718721 ttggcagcac aacggtggca atgacaagcg tgcataaaat gacgccggct gctaaaaaga 2718781 gaatcagatt tctttccgga aacggcgtac cgtcctccag gaaatacgga atggaaaaag 2718841 aacctgcaag cgttactgct ccacgcacac cggaaatcga aattaacagc gtcgaacgaa 2718901 gacccggttt atagatgttc tgatctttat taaagaacca tttgccgttc cagaagaaca 2718961 gcacccacag gaatctaagg agcattaatg taaatgtgat gactaggata tagccgatca 2719021 ccttcatgtt gctgatggca gtgtcgttaa agataacaga aataacatca gggatttgcg 2719081 tgccgagaat aacgaagacc aggccgttca aaataaataa aataatgttc cacgtacttg 2719141 aggagacgat ttgcagcttg atcatcgttg attccagacg atcctgttca accgcatggg 2719201 taataccgcc agctacaaca gctaaaatgc ccgaaacgcc gatttcttca gctgccaaat 2719261 aaatcacaaa cggcgtcaga atttgaatca gcatatgcat cgtgacatcc tgcatgccaa 2719321 ggcggcgcag aaataggcga aaacgaataa tcaaaaatga aatgacaacc ccgcacagca 2719381 agcctccgag agaaataaag acaaagctga cagccgcttg tgctaatgaa aatgcaccag 2719441 tcactgccgc tgcaatcgca aacttaaagg ccaccagacc tgatgcatca ttcatcagcc 2719501 cctcaccttc cagcaggcga agaatccctt ttggcatttt cactcttcct gataatgcgc 2719561 tgacagcgac gacatcagtc ggtgaaagaa tggccgcaag tccaaaggcc gctgccagcg 2719621 gaatagcagg aatcatccag tgaatcgtgt agccgcctac aatcacagtc gcaaatacaa 2719681 ggccgagtgc aagcaataaa atcggagccc ttaaattcca aagctctgcc cgcggtgtcc 2719741 tctttccatc attaaatagc agaggcgcga taaaaagaac aaaaaacaat tcggtgttta 2719801 attcaaaatg aagtccctgt ggaaatgagg cggcaagaat cccaagagcc acttgaatca 2719861 gcggcaccgg aataaacgga ataaaccggt tcacgatatt agaaatcgca ataatcgtta 2719921 ataatacgag cacaactaaa aatatgtcca aatgcatgac ctccttcgtc tgttgtgtgt 2719981 cggcatgatg agccaaaaaa tctgtttgtc taaaagccct tgagctaggg tggccttgca 2720041 tccgctatgt ggtttcgcag gagttctctc cacacttgtc ttcttttata gtaccctttt 2720101 tagggtattt tttctcatga tatgctcaca gtgaactttt ttgcagaaga gcaaattata 2720161 gaaaaaagag acaggaagct actccctgtc tctcgtcttt ctttctcaat catgaaaatt 2720221 cgtaccgtca gttgttgctt taataatgcc cgcgcgaatg acaaagtcac cgaaatgctc 2720281 gccttcctcg cgttctttcg catagcggga aagaaggatg cgcagctcgc ttaaaatgtc 2720341 tgcttcaccg atgttttcac ggtacatttt gcttaaacgg cttccgtcaa acgcagcgcc 2720401 aagatacata ttatatttgc ccggcgcctt tccgataaat ccgatctcac cgagtgcatg 2720461 acgtgcacag ccgttcgggc atcctgtcat gcgaatggtg atttcctgat cacgaaggcc 2720521 gttttcgtca ataatctctt caatcttatc taacagggtc ggcaaataac gttctgcttc 2720581 agccattgcc aatccgcagg tcggaagagc gacgcacgcc atcgagctgc ggcgaagcgc 2720641 tgaatagtgc ttgccgtcag ttagtccgta ctgttcaatt aaagcactga tttcttcttt 2720701 tttatcgctt gaaacgttcg caatcattaa gttctgattg gctgtcagcc ggaactcacc 2720761 tgtatgaact ttggcgattt cccgcaagcc agtcatcagc ttataatcat cgtaatccgt 2720821 tatacggccg ccttcgacaa acagcgtgaa atgccattta tcctcgatgc cttccaccca 2720881 gccatagcgg tcgccgttat gatcgaaatg atacggcttc gcttcttcca ggctccagcc 2720941 gagacggttt tccaattctt cttttacgtt ttctaaaccg aggcggtcaa ctgtgtattt 2721001 gaaccgcgca tttttacgga cagaacggtt gccgtaatca cgctgaatcg taatcgtttt 2721061 ttcagcaacg tcatacattt gctcaggccg gcagaaaccg atcaccttgg ctaattgcgg 2721121 atatgtcgca gtatcgccat gcgtcattcc cataccgccg ccgattgcca cgttaaaacc 2721181 gatcagcttg ccatcctcga caatcgcaat gaatccgaga tcttgtgaaa agacgtcaat 2721241 atcattagac ggcggaacgg caataccgat tttaaacttc cgcggcagat agagcggtcc 2721301 gtacattggc tcgacttctt cctccggcgt gccggcaact ctttcctcat caagccaaat 2721361 ttcatgatat gctctcgtcc gcggcagcag atcatcactt aattttttag accactcgta 2721421 tacctctgag tggatttcag attgataagg gtttgatgca cacatgacgt tacggtttac 2721481 gtctccgcag gctgcgatcg tatccaaaag tgctgagtgg atcgtctgaa tggttttctt 2721541 catgttccat ttcagaattc cgtgcatttg gaatgtttca cgtgtcgtca attttaatgt 2721601 gccgttcccg tatttctggg acaggtcatc catgacaagc cattgttcag gcgtcgagac 2721661 gccccctggc atacgcacgc gcagcatgaa ctgatatgcg ggctcaagct tctgcttttg 2721721 gcgttcattt cggaggtcgc ggtcatcctg caaataactg ccgtggtgtt tcatcaggcg 2721781 gttatcatca tccggaattc ccgcactgat tcgatcgagc atcacttctt tcagcgtgcc 2721841 gcgcaaataa tcactttctt ttttaatgcg ttcaacatca cttggagagc cgtccggtgc 2721901 ttttagaatt ttggtcacca tgttgaaaaa ctcctttcaa gtcaaatcaa tatacatcac 2721961 gctgatagcg tttttgctgc tgcatatcgg caagataagc ctccgcctct tcgcggctca 2722021 tattgccttc tttttcgata atttcaagca atgtgttatg gacgtcatgc gccatgtgct 2722081 tttcatctcc gcaaatgtaa acagccgctc cttcttgaag ccattcaaac aattctgcgc 2722141 tatgttcaag catgcggtgc tgcacatata ctttttcttc cgtatcacgt gagaacgcca 2722201 catccatttt tgtcagcaca ccgtctttga gccaattctg ccactctgtc tggtaaagga 2722261 aatccgtgac aaagtgctga tcgccaaaga acatccatgc ctttccttcc gctcccgtct 2722321 cctcacgctc ctgcataaac gaacggaaag gtgcgacgcc tgtcccaggg cccaccatga 2722381 taatcggtgt ttcagggtct ttcggaagct taaagttttg attgtgctgt acataaaccg 2722441 gcagtgtgtc tcccggctgc agtcgttccg cgcacaaaat cgagcagacg ccttttcgtt 2722501 cacggccgtg cgcatcgtag cggactgcgc cgattgttaa gtgcacttca tccggatttg 2722561 cggataaact gcttgcaatc gaataaaggc gggcaggcat ttttcgcaaa atcgagacaa 2722621 actcctgcgc agatacacta aatgggccat agtcacggac gagatcaagc aaatcgcgcc 2722681 cttcaatata ggcttttaca ttctcctcat ttcccggggc taaaagctct ctaagctcat 2722741 cgttccctgt cagctgggct gcctgttcaa gaagcggttt tgtgagaacg gtaatctcat 2722801 agtgagaaat cagcgcttct ttcagcggtc ggacatcacc ttgcttatta agcgtcacaa 2722861 tttcttccgg gtcccaattc atttccttaa ggagcagctc gacaagttcc ggatcgtttt 2722921 ccggatagac gccgaggctg tcaccaggct cgtaagtcag gccagatcct tcaagagaca 2722981 gctccacatg gcgtgtttct ttatttgatc ctctgccgtt taaatttaaa ttttctaaca 2723041 cttcagcccg aaacgggttt gttctggaat acgaagactc accggtttgt gacgcagccg 2723101 ccggcgcagg cgcggcgctt ccgcccccag cttcatttaa tcctttcaat acaccctcaa 2723161 gccattcggc tgccggttca tcatagtcaa gatcgcaatc aacgcgcgga gaaatccgtt 2723221 ttccgccgag ttcttctaag cgttgatcaa attctttccc tgtctggcag aaaaattcgt 2723281 acgaactgtc accaagcgcc aaaacggaaa agcgcaggtc ttcaagctta ggcgcccgtc 2723341 ttccgtgcag aaattcatga aacgacagcg cgttatcagg cggctcgcct tctccatgcg 2723401 tactgacgac gattaaaaga ttggttacct tcttcagctg attcggctta aaatcgctca 2723461 tggatgagac ggtcacttga aaaccgctct gttcaagctg cttgccggca ttttctgcaa 2723521 gcccctgtgc gtttcccgtc tgtgaaccat aaagaacggt cacttctttt gaaacggccg 2723581 gtgccggtgc ttccgctgac acagctgccg ccggcgtacc cgcagcttct tgggcggaaa 2723641 cagattgagc ggataaatat ccgctcagcc agattttctg ggattcggtc aaggtcggca 2723701 gaaggcggtt aaggagctct gcctgctcct gattaaacgg actgttcatt acctgaagtt 2723761 gcaacgtatc cacctcacaa agttataaac tgatcgaaaa ttgcatctaa ttgaacttta 2723821 ccggaatact aggcttaagt aaaatatatt tacatgatga taactattaa gaatcctaat 2723881 gataaaacgg ctatgcttca tgtaaataga aaaaagagaa ggactccctt ctcttcattc 2723941 agcaatctga tataagtgag gcggcacagc ggttacaaac ggactggctt cacctgtata 2724001 aaataccgcc agcatgtgca tcgcacgggt gcacgcagta tataaaagcc tgcggtcgtg 2724061 ctctgtatga tagtgttctt cagatgcatc atagacaagc actgcgtcaa attcaattcc 2724121 cttcgctaaa tacaccggaa tcacgcaaac acccttttga aatggttgat tttctttatg 2724181 aatcaggcga acatctgtat attcactcat gtgggcgtgc gcctgtatgc attgatgcgc 2724241 agtcttgcag atgacggcta ttgtttcgtg cccttttttc ttgagccggc caatttcttg 2724301 cgcgagcttt tggcaaaggc tctcatgtcc ttcagttttg acaacgagcg gcatttcccc 2724361 gcttctatta aacggctcaa tatccgctcc atcttgaagc atcgctttgg taaactcgac 2724421 aatctgcctt gttgatctgt atgttctctt taaacgaaca tactcagcag gctcatcctc 2724481 aaagcacgca tccatacgct gatccccgtt tatggtatgc gcgtagatgg actgattgat 2724541 atcaccgagc actgtcatgc tggcagccgg aaaaatgctt ctcatgtaag ccatctgaaa 2724601 cggtgaatag tcctgggctt cgtcaataaa tagatgtttg attttcgtat ttttctttct 2724661 gccctcaatc agatcctgca tataaagaaa cggtgccgcg tcctcataga gcaatttatt 2724721 atccgtaaat gccgaacggg tcagctcacc tatcgcatcc atcttctcat gttgaaattt 2724781 tcctccccag ccagaaaaca attgcaaata aagttgtgta acatcaagaa atgcaaggag 2724841 cctgactgcc tgtttgagcg gtttgaaagc ttttttcaca atgatggcgg caagcagctg 2724901 ctgctctctt tgataatcgt taaacgtact ctcgctgaac cgtttccttt cctgcagttt 2724961 tttgtacacg tccaagtagt cctctttgtc aagcagctca gcttcatgaa caacccaatc 2725021 ctttcgccgt tcctttttct caagcttgtt aagctcactc agcagccact tcgcggtttg 2725081 ctccatccga ttcggaatgg agtgattttg atccaatgag taaaaatagg attgaatttg 2725141 ctcctttgtg atcagctttt gtccgcggaa tataatattt ttaaaaatca tcccttcaga 2725201 ggaaagccgt gtgacgtatt cattaatgaa ttgctgaaag gataaacccg ccttccatgt 2725261 gattcctgca agccttgttg gaaaatcgcc tccctttgtt tcggtcaggc aatattcgag 2725321 ctgatcaaag gggctttcac atttgaactt gcggccaaga cgatgctcga tatattcctg 2725381 aaacgtcgcc tgctccatat tctcttctcc taactccggc aaaacagagg agacatagct 2725441 gttaaataag aagttgggtg aaaacaaaac gatttgtccg gcatcaatga caccgcggtg 2725501 cctgtataac aaataagcga cacgctgaag cgcagccgat gttttcccgc tgccagccgc 2725561 tccctgcacg atcaggatct tgcttttttc attacggata atctgatttt gttctttctg 2725621 aatcgtagac acgatgtttt tcatttgggt atcagagtga tggcttaata cctcttgcag 2725681 catttcatcg ccaatcgtca tatcggtatt aaacatcgcc ttgagagtgc cgtttttgat 2725741 cataaactgg cgtttcagca ccatttcccc ttctatcgtt tcaccgggca cctcgtactc 2725801 cgcttttcct ggggaataat tgtagtacaa acttgatatc ggcgccctcc agtcatagat 2725861 cagaaagtgt tcctccttct catccaaaca ggaagctaaa ccgatataaa ttcgctctgc 2725921 ctgctcctcg ccgttttcaa taaaatcaat ccggccgaaa taaggcgatt ttttcaattg 2725981 atgaattcgt ttgagctgct gatccatgcg ccgatgattg tgttcccgat cagacagcag 2726041 ctctgcctgc tgcttaatgc tagccatcgt ttcaatcgct tcatgggcat catcaaaatt 2726101 aaccttaaca tcctcccaaa agctttttct taatccgatg atatcatgct tcaacccgcc 2726161 cgcagacgtt tccagaaacc gctctttttt ttcgagctcc ttcagcacct catctattct 2726221 cgactgctct tccttccatt ccttatcctg ctgattcatg aacggcacct ccagaaaata 2726281 gttgacaaac atagatgaaa tactgtaaaa tataattgga tacatatatt aaatatatga 2726341 tgcaaactgg caaatacaat ttataatagc acattcaccc aataccaatc aaggtttggg 2726401 ttatttatat tatgcagaaa aaaaccgatt tcacttcgaa atcggttttt ttgctattaa 2726461 ttatctaagc gaaaagaacg gtttggcagc ttccaattaa acatatagga acaaacccgg 2726521 caaacaacga gcacgaaaaa cagaacgtat aagccgaacg agttccccag ccagcccaag 2726581 ccgacgatta aaccgccgag cgccgcccat accgcataga tttccgcttt cagcacaagc 2726641 ggtttgcgcc cggcaagaag gtcgcggatg atcccgcccc cgcttcccgt cagcaccgca 2726701 gccacgatca cggcactaag cggatggccc attttgacgg catacagtgc gccttggata 2726761 gcaaaggcag cgaggccgat cgcatctgat aaattgcccc acttattcca atgcttcagc 2726821 agcagcttcg gaaacagaaa cacaattgta atagataaaa gcgcgatttg aaagtacgct 2726881 ccctgctccc atagcgctga caccggaaca ccgatcagca aattgcggat cgctcctcct 2726941 ccaaaagctg tgacaatccc taatatataa actcctaaaa tatcatattc ctcttccatc 2727001 gcaacaattg cgccgctgac tgcaaacgca atgatgccaa tcacactaag cagctcccaa 2727061 gccattctga tgactccctt ttatgtttgt taaattttct gacgacctct agattttata 2727121 atcgctccag cgtaaaatca ataacatttt catgagaaaa aaagataaat ttagagggaa 2727181 tacggctatt gctgatggac atgagtttgc gaaattaaaa aagcgcccgg catacgcggg 2727241 cgcttttttt gttattcaga tttttcgcct ttcagcaggc acataaaaat gataatcagg 2727301 ataaaagcaa tcagggccag gaatggaatc gtaataaaac caaaccagtt aatatattgg 2727361 cccgagcacg gcacgccgct gacacatggc ttaatgccgc taaagccggg cactttttgc 2727421 tctaagtaat gcatgatcga aatgaatgcc ccaataatcg ccatcgggag cacatatttt 2727481 ttcactcgtg tgtccccttg aaaggtggcg atgcctaaaa tcaggacgag cggatacatg 2727541 aggatacgct ggtaccagca cagttcacat ggaataaact ttctgatttc actgaaatac 2727601 aggctgccca gcatagcgat aagagccaca acccaggaag catataaaaa tacgattcta 2727661 tttttcatat tgttacttcc ctttcagctc tttttctatt gtctctttga tttcatcata 2727721 atccgcaaaa tttttgatca ctttatcatt gacgtaaatc gtcggtgttg cctgtatgtt 2727781 cattttttga ttaaggtcag aatccttttc cacttgagaa gcgaatgttt ccttatcaag 2727841 attttccttg agcgtctcag gttttatctt tgtggtgctt tttgcaagat caccaaggag 2727901 gcctggggtt acccattcct gttccgtatc cggctgtttt tcgaacagct tttcatggaa 2727961 atcccagaaa gagtcagggt cttccttcca tacttcttca gatgcaagag ccgctaacct 2728021 tgaacctttt ccatggaaca tgacgttcac gaaagaaaat ttcacatcgc ccttatcaat 2728081 aaagtctttt tgtatttttg gaaagatgtc actgttaaac accttgcaag acggacattt 2728141 gtaatctccg aattctacta cagttaccgg tgcatcgtcc ttgccaagca caggctgccc 2728201 tttgatagac ggctgtccgg acaccgcatc attgccttgt tccgttttgt tattaatgat 2728261 gacaatggct gctagcaata caacaaccac aaccgtaagg atgaccgcga atttcgcaga 2728321 agactgctgt ttctttttca ctccgacacc tcatcgtttt aaaattaaaa aagaagcgga 2728381 tcgcaattga cccacttctt tattttaaca agacaagcgc tgataagaaa accccgaaaa 2728441 aatgaattct ctccgacaat ttatttgttt ttgagacgca tgacgcgcat ggcgttcgcc 2728501 acagcaagca gtgtaacgcc gacatctgag aaaaccgctt cccacatggt cgcaattcca 2728561 aatgcaccaa gaatgagaaa gatcgctttc acacctaaag caaagccgat gttttgccac 2728621 acgattcgcc gtgtccgttt cgcaatccga atcgcttctg ctatttttga cggctgatct 2728681 gtcatcagca cgatgtctgc ggcttctacc gcggcgtctg agccaaggcc tcccatcgca 2728741 acccctatat ctgcgcgtgc aagcaccggc gtatcattga tgccgtcacc gacaaaaatg 2728801 agtttttcac taggcaaaag cttagcttct aatgcttcga cctgcgcgac tttatcttgc 2728861 ggcagcagct ctgcatatac ctcaccaatc ccaagctgtt ttccgacggc ttctcccgtt 2728921 tgtttcgaat cacccgtcag catagctgtc tgtttgatcc caagcgactt cagatcagca 2728981 accgcctgtg ctgcgtcttc ctttatctca tccgctatga tgattgctcc ggcatagcgt 2729041 tgatctacag caacgtgtac gattgttcca gcattttcat ccgggacatc ctcaatttgt 2729101 tctctttcca tgagcttttt attcccagca aggatctcag ttccatttac ctttgcaaaa 2729161 atgccgtgac cggagatttc ttcgtatgac tcaatctcat cggaggaaag cattttcccg 2729221 taagctttac gcacagattc agcaatcgga tgctgtgaat gaagctcagc gtatgccgcc 2729281 gcttcaagta atctatcctt tgtaaaacct tccgcgggtt tgatttctgt cacttcaaag 2729341 ctgccttttg ttagtgttcc cgttttatca aacaccgcgt atttgacttg attcaaagct 2729401 tctaaataat tgcttccctt tacaagcact ccggcctttg aggccgctcc gattccaccg 2729461 aagaaaccga gcggaataga gacaacaagc gcacaaggac aagaaatcac taaaaagata 2729521 agcgcgcggt acacccaatc ggaaagcgcg gcgccagaaa gaacaagcgg cggaacaaag 2729581 gccagcaata ccgcaatgat caccacagca ggtgtataat acttggcaaa cttcgtgata 2729641 aagttttctg tccgggcttt acggctgctc gcattctgaa ccaagtctaa tatttttgat 2729701 actgctgatt cctgatagcc ctttgtgact tcaatatgca gaacgccgtt ttgattgata 2729761 aagcctgaca ttacatcttg tccttccgca gcttttctcg gaacggactc acctgttaaa 2729821 gcagatgtat caaccatcgc tgacccttgc acgaccttac cgtccagggg tatgctttct 2729881 cccggattaa ccacaatgat gtctcctgtc tgaacgtcct ccgacgaaac ctgttcgatg 2729941 ccgttctttg ttttgagatt ggcgtaatca ggccgtatgt ccattaacgc actaattgat 2730001 tttctggaac ggctgaccgc ggctccttga aaaagctcac cgatttgata aaacagcata 2730061 acggcgaccc cctcagggta ttgctgaatc agaaaagcgc cgattgtggc aagagccatt 2730121 aagaaatgct catcaaacac ctgaccgcgg atgatgtttt tgactgcgcg gattataatg 2730181 tcaccgccga taatcaaata agcaccgagg aaaaggaaaa attcaatggt tcccgactga 2730241 accaaatatg ccgctgcgcc gagaatgaca gccgccgcca ttctgatcag catattgacc 2730301 attcgattac gatagccatc atcagctgat ttctttatat gcttttggcg aaccgttaca 2730361 tgcggatcaa ttgatttcac ttttttctct actttattcg tgacccattg ctcttctttc 2730421 ccatcggctg agacagttaa ggtgcttgcc gcaaaattta ccgcgcatcc gttaatgcct 2730481 tttatgcctt tgactccatt ttcgattttt cgggcacaat tgctgcaatc caaaccgtcc 2730541 agaacatatt cctgtttcac tagtctcacc ttaccttccg atttagggtt ccctcttcaa 2730601 agcgtatcaa tgagtattgt atttatttta tatatatgag catatactca tatataagtt 2730661 acacctatta tatgttgttt tccaagaaag tgtcaatgaa aaacaaaaac cggcatatag 2730721 ccggtttttc attttacttt ttgcagacga agagcattca gaacaacgga aacggagctg 2730781 aatgccattg ctgctcctgc tatccacggt gctaaaaatc caagtgctgc gattgggatg 2730841 ccgaggctgt tatagccaag cgcccagaat aagttttgtt taatgttttt cattgtcaat 2730901 ctgctcatgc ggattgcgtc ggcaatgctg ttcagatcgc cgcgaataag tgtaatgtct 2730961 gctgtttcca tggcaatgtc cgtgccagtt ccaatcgcca tgccgatgtc agctgtggca 2731021 agcgccggcg catcgttaat tccgtcgcct accattgctg tctggcggcc ttctttttgc 2731081 aagcgggcga tttccgccgc cttttgttca ggaagaactt ccgcaatgat attcgcaatt 2731141 cccgcttcct tcgcgatggc ttctgcggtt ctgcgattgt ctcctgtcat catgatgaca 2731201 tcaagaccca actctttcag acgggcaaca gccttccgcg acgtatcctt aatcgtatct 2731261 gcaactgcta ctagccccgc tgcttctcca tcaatggata caagcataac tgttttccct 2731321 tcggcctcta gctcttccat ttgggcgaga agagccccat gctcaacctg ttcgctctcc 2731381 attaattttc ttgtgccgac gagaatgctt tttcctccgg cttcagccaa aatgcctgcg 2731441 ccgacttttg cttcaaagcg ggtaagtttc ggtatctcaa gccctttatc tttcacgcca 2731501 gcaataatcg cttcgccaag cggatgctct gatcccgttt ccgctgccgc tgcaaattga 2731561 agcaaatctt tttcttcaaa acggccgaat ggaatggcat ccgtcagacg cggcttcccg 2731621 tttgtcacgg ttccggtttt atcaagaaca attgtatcga gacgatgtgt tttttctaaa 2731681 tgctcgccgc ctttaaataa aatcccgaat tcagcagcgc gtccagatcc agccattatg 2731741 ctcgtcggag tggcaagacc gagggcgcaa ggacaggcaa tgacaagaac cgcaatgaac 2731801 ttgctgatcg cttcggcaaa atcgccagga gccgcccaaa gataccaaat gagaaaagtg 2731861 agaaccgcaa tccccaatac aatgggtaca aaaatgcctg aaatctggtc agcgagacgc 2731921 tggatcggcg cttttgaccc ttgtgcttcc tcaacaattt tgatgatatg agaaagcgca 2731981 gtatcctttc cgacgttgac agctttaatt ttcagaaagc cgtttgcgtt aacggttgaa 2732041 cctgtcacgc tgtcaccagg atttttgtca acaggaagac tttctcctgt aatcatcgat 2732101 tcgtcaaccg ctgaacggcc ttcaaccact tctccgtcga caggaattcg ttcgccaggt 2732161 ttgacgtaaa caatgtcatt aacaagcact tcgtcgatcg ggatgatttg ctcctgtccg 2732221 tctcttacaa cagtagctgt tttcgcttga agcttcatca gctttttaat cgcatccgag 2732281 gaacggcctt ttgcttttgt ttcaaacaac ttgcctaata aaatcagcgt cagcaaaatc 2732341 gcgcttgttt cataataaag gccgtctgta tgcccgtgag agccaatgct ttgaaaagtt 2732401 agataaagac tataagcgta agcagccgtc gtaccgaggg cgaccaatac atccatattg 2732461 gcgcttttat ttctaagcgc cttatacgca cccacataaa acggccagcc gatcagaaac 2732521 tggactggtg tcgccagcgc aaactgcatc cacggattga gaaatatatc cggtacccaa 2732581 atgaatgatg taaatgtaaa atggctcacc atcgcccaaa gcaatggaaa tgacaggaca 2732641 gctgaaaaaa tcagtctcgc cgtttgcttc cgttcttctt tctttttagc agcagcctca 2732701 ctgtcctgtt cacccttcaa ctttagctta tatccaagct tatctaccgc ttctttcaaa 2732761 tcgctgacag acgcttcttt tggattgtat tcgaccgtaa ctgtttctaa agcgaagttt 2732821 actggtgcat ttgcgacgcc ttctattttg ttaagccgtt tttcaatccg attggcgcaa 2732881 gccgcacagg tcatgccctc aatatcgaat tcagcttttt ctgtaacgac gtgatagccc 2732941 agcttctcta ttttttcctg aatcgctgca gtccctgttt cagcaggatc gtagattaca 2733001 tttgatgttt ccgttgccag attaacattt gcatccgtga caccgggcat ccgcttcagg 2733061 cctttttcaa ttctggcagc acatgccgca caggtcatac cagagacctg catcgcgatt 2733121 tccttttgtt cactcaacat actcactcct ttatatacac ctggggggta tataaaaatg 2733181 aaagaaatat cgcgcctccc taaaggcgcg ataccttgaa tcacttggct acgtcatagc 2733241 cctgatcttc tatcgcatcc gcaatatctt tgactgatac tttgtcagca tcaaacgaaa 2733301 catcgacttt acccgcttcc agattgacat gaacggcact gacgccgtcc agttctccta 2733361 cgcttgtttc tactgctttg acgcagtgct gacaagacat tccttcaact tgcaatgttt 2733421 tttgttccat atcaattcct cctgtttatt ctttctattt tcatcctacc atacccccgt 2733481 agggtattac aataaaaaac gctttatgat tttgtgaact ttttaaatac gtccaaaagc 2733541 tcagaaatgg cctgttcccc gtctccgctt ttgatggcat ctgctacaca atgatgggca 2733601 tgatcctcaa gcaaatgaag cgccacattt ttcattgccg cctgaacagc tgaaatttgc 2733661 acaagaatat ctacacaata tctgtcgttt tccaccatgt tttgaatgcc tctgacctgg 2733721 ccctcaatcc gcttaagccg gtttgtaatc tgatcctttt ctttcgagct tttatggttt 2733781 aatgttttat gttcgttatg cttttccatg cgtacacctc tgtttaatga tattaattcc 2733841 cattatactg attgtccaaa cggttgtcta agcatgccga cgcaaaaaat gaatcagtta 2733901 ggttttacca tttgatcagg agggtatata cttctgttga taacgctttt aaaggggaga 2733961 agaaaagtgg atacgatcaa ggttggaata ttaggatacg gattgtccgg ttctgttttt 2734021 cacgggccgc tgctggatgt tctggatgaa tatcaaatca gcaaaatcat gacatcacgg 2734081 acagaagaag tgaaacggga ttttccagat gctgaggttg tacatgagct tgaagaaatc 2734141 acaaatgacc ctgccattga gcttgtcatt gtcaccaccc cgagcggcct tcattacgag 2734201 catactatgg catgcataca ggccggaaaa catgttgtga tggaaaaacc aatgacagca 2734261 acggccgaag agggggaaac attaaaaagg gctgccgatg aaaaaggcgt attattaagc 2734321 gtatatcata accgacgctg ggataacgat tttttaacga ttaaaaagct gatctctgag 2734381 ggatcccttg aagatatcaa tacatatcaa gtttcctata accgctacag acctgaagtt 2734441 caagcgcggt ggcgggaaaa agaaggcact gccactggta cgctgtatga tctcggctcc 2734501 cacatcatag accaaaccct gcatttgttt gggatgccta aagccgtgac tgcaaacgtg 2734561 atggcccagc gggaaaatgc cgaaacggtt gactattttc atttaaccct ggattatggc 2734621 aagcttcaag ccattctata cggaggatca atcgttccgg caaacggacc tcgttatcaa 2734681 atccatggaa aagattctag ctttatcaaa tatggaattg acggacagga agacgcactc 2734741 agagcgggaa gaaaaccaga ggatgacagc tggggtgcgg atgttccgga gttttacgga 2734801 aagcttacaa ccattcgtgg ctccgacaaa aaaacagaaa cgattccatc agtaaatggc 2734861 tcctacctta cttattaccg taaaatagcg gaaagcatac gagaaggtgc tgcgctgcca 2734921 gtcactgctg aggaaggtat taatgtcatc cgcatcattg aagccgcgat ggaaagcagt 2734981 aaagagaaac gaaccattat gctggagcac taaaacaaaa gcctccccaa ataaggggag 2735041 gctttttcat tagaatgttt ttcctgcttc tttcgcacgc gcaatcgcgt cttctttgat 2735101 ttgctgtgct ttatcaggct ccgcattatg tccctctacg aaaatgccat cgaatgatgg 2735161 tacgccgaag aagttcatca tgatgccgat gtagcggtgc cccatttcca tctcagccgc 2735221 agggccttct gaatagtagc cgccgcgcgc ttggatatga attgcttttt tatcagttaa 2735281 caagccgaca ggaccttgtt ctgtgtattt gaatgatttt cctgcaacag caacagaatc 2735341 gagatacgct ttcatcactg gcgggaatga gaagttccat aaaggagtaa caaatacgta 2735401 cttatcagct gatgcaaatt gatcgctaag ctctcccaaa cggcctactt tcgctttttc 2735461 gctttcagaa agctcttcaa agcctgtacc tgactgaagc tttccccatc cgctaaatac 2735521 atctgcgtca atgtgcggaa tgttttcttt gtacaaatcg atatgtacaa cttcatcatt 2735581 tggattcgct tctttgtaag attcgataaa tgctttacct gttgccatac tgtacgaagt 2735641 tgcttcgtca tgtggatgag cagtgatata taatactttt gccattttta ccagcccttt 2735701 cgtttttaaa aatcacacat caattattat catacagatg cataatgatt attctgtctc 2735761 tcttagactt tattatagag acaaagaaat ttactttcaa gtaaaacatc tcgaattaaa 2735821 gattatttaa ctttcccaaa cagcttactt ttcaaaagct gttctcaagc cggaatacag 2735881 cgcggacaat tctttactga tccgaggata atgagggaca tgcggcactt gaatatccgc 2735941 aggcatcctt ttcatgataa aggattgctc agcctgttca aaaaacgccc gcagctggtt 2736001 gatctcttca tcagaaaacg gagcagacgg acggcggtga gcttgcgccg agagcaaata 2736061 gtaccctaag tgctgagcac cggaaatggc aggccagagc gcatccgcat tcgcgtgagg 2736121 aaactcgcca agcgccttgt catacgcatc ccgaagcctg acaagactca cccttaactt 2736181 gtgttcgtcg gcaatttgcc cggttaacag tttctccata aactgccctt ccagccggat 2736241 gacattccgc acaagttctg gcagccgctt ggttgaaaac cgccgccaca aaagcattgt 2736301 tcccaacagc ccgatcacgc tgccgacagc tacatcagtc agcctcgcta tcataaaata 2736361 accggcgccc gccccgccat gcatactttc tgtgataaca agcgcatttg cggttaaaaa 2736421 gggaacagcc agcgcataat tgcggacgat cagcatctca agaagacatt gcagcgctgc 2736481 aatacaaaac gcaatataaa caccgcccgg cttaaaaaac aggattgcgc ctgccagtat 2736541 aacaccgatc accgttccgg ccgaacgctg aatagccctg tgaagcgtaa aaacaacagt 2736601 agtgccaagc atgaccgctg ctgccgaaag cggaatccaa taggagcgtg caaagccgaa 2736661 tgcgagggca aacatatcgg cggcaaacag aacaattccg tactttaacg ctctaatcaa 2736721 aactggagac ttccagtcaa aggcatttct caaaaagtaa aaagaggatg gcaggcggct 2736781 tggttccccg tcaagctgct tatcaaaacg tcctgaagcg atatacaaaa cctcattgat 2736841 ttcttcaaac agcttccgcc taggctcaga ttcattttca ttaatctgaa acgtattgaa 2736901 aacccgtgca ttcgcaagca tatctccggt ttggcgaagt gccttttcaa tctgcgcggt 2736961 ctctctgtcc ggcgtttcag ctgaaaaatg aataatggca ataaatatgt cgtcagcttt 2737021 ctcaaggagg cgaaaaaatc gttcatcatg ccgcgatttt ttccgtctgt tccctttccc 2737081 aagaaccgtt tggcgggctg ttctaagcat gagcaccgtc tgatgctgtg cgttatgaaa 2737141 acctggcgtt ccgacggctg aaagacatgc agccagctga tgatatgttt tttgcagcac 2737201 cgctccctcc ggtccatgtt tgttccataa ccagccgatt aaagcgatac ccatggcgaa 2737261 aatgccgccg agaaacgtca gtcccgctct gaacagcgct tgtgaaggat cggccggcag 2737321 cccggaactg actaaaaagg caaggacaaa aaacatcggc gcagggcctt gaatgccgag 2737381 cgcgctaaaa ataaacatcg ccgctgcacc gatcagcccc aaaacagccg ccatcatcca 2737441 aagcatcccg gacaaaagcg tccctaaacc aaatgagagg gcgatcccaa tagaaaccaa 2737501 gagcagcttc aaggcgcgct ttttgtacga ttcaccgccc gcatataaat aaacaaagcc 2737561 tccgatactt gcaattaatc cgtaatccgt gtgacctgcc aatgcaccga ccagcacagg 2737621 aaaccctgaa gcgaaacctg atccgatagc ctttttccaa ggaaatggat ttgcatgaat 2737681 gcgaaaggca tccttcacga taggcatgat tctttgattg ttcgcagcag ttttgttcat 2737741 ttgacaaaat ccttttcaat gaatgtgtag aacttttcca gtttcttcgc tttagtatgc 2737801 ccaaaaacgc ggttagcttc tcaattggtg cgcacgataa aaaaacagag acttataccg 2737861 tctctgcttc attacatcag tttattataa aagcggcacc tgtcaggact gttttgtcct 2737921 tctgccttcc ttcaagagca ggtgaataaa aaataaagga taaatcaata gatacccatt 2737981 aaacagccac cacacaagat caaagtcact gctgaatgtc cagaatgata gcgcctgcag 2738041 acctgaacaa caggtcagca caagagaaat cagcgccatc agcttccagt cagcacgatt 2738101 cacccgctgt aggtacaagc tgtacaaccc tgtgacagaa atcaggatat ccagcggaaa 2738161 aaaagaccag ttccaagcga tcataaacgg atggtcatga tgtttaaaag cccagctttc 2738221 cggtatgagc gaaaatccgg ctgacagcca gtacaagata aaaccgatat cagtcacgag 2738281 aaaaaacagc ttcatatatc tcatttgtac tgcccgcttt tatgtaccgg ctcagacacc 2738341 gcaacatgct cgatcaggtt taaagacaca acaccggcaa taatcaatcc aattgaaatg 2738401 actttcatga cactcacatg ttcttgaaaa aacaaaaaac caacgactgt aatcaagaca 2738461 attcccatcc ctgaccatac agcataagca actgatacat caatggattt aagcgtaagc 2738521 gtcagaaaga aaagactccc tccataaaag aaaatcaaca gcaaactggg aataagcttt 2738581 gtaaaaccag acgatagctt catgctgaca gttcccgcaa cctcaaacaa aatcgccaag 2738641 catagaaaca cccaattcat gtggcatcag cctcctcatc agctgttata ccgttaaaca 2738701 aaacatctac aattgattca agtacctctc ctgtcgtgaa ctgatgtttc agcggatatt 2738761 cagggtcata cacttgattg atgctcccta tatacatgtg aacaaacagg tccggattga 2738821 tgtttctgat tctcttttgc tgtttgcact catttaataa tgctaggaca atcgcccatt 2738881 cttccttaat aaacgcgtct aatgtaagcc acgcatcgta atggtatttc tttagttcat 2738941 ttaataatcc catgttcagc agttccatcc cctgcggaag gctgatcagc atttgtttca 2739001 ccttttcgag cacatttaaa ctttcatttt catagatgtc tctttctatt tgcttcattt 2739061 cagctataaa ttgttcgaca accgcctcaa caagctgatc tttagatgaa taatatgcat 2739121 agagcgtccg cttgctcgtt cccagcgctg ccgccaaatc attcatcgta aatgaaaatc 2739181 ctttctgctt gatcagccgg aaggtttccg ccagaattct tttatccata ttaatccccc 2739241 gctttcggta ccaagaaaac tatttcggta ccaatattat acggcagaaa tttatggaaa 2739301 tcaacaatat ataaaaaaac ctctcctatt gggagaggtt taaaagacac tgcggaccaa 2739361 accgccgtcc gcccgaagtg ccgcgccatt gatcgcagag gaaagcggac tgcttaaaaa 2739421 tgtaacgaag tgggcgattt cttccggacg gatcagtctt tgaataatag atgtcggccg 2739481 gttttctttc ataaaacgtg cctcagcttc ttgaacagtc aggttttcac caggatacag 2739541 cgagttcagc atggtttcca caccctctgt taaggtagag cccggcatga cggtgttgac 2739601 tgtgacattc gtgccggttg ccagctccgc caaactgcgg gaaatggaca gctgcatcgt 2739661 ttttgtcgca ctgtaatggg ccatttcctg tgacggcata atcgccgctt cactggcaat 2739721 gaaaatcaca cgcccttctt ttttctctat catgttatgc aaatacctgc gtgtcagcct 2739781 tacaccgctc ataatattca cttcaaaaaa acgaaaccat tcatcgtcgg gaatatcaaa 2739841 gtactccgcc ggttcaaaaa tccctaaatt gttgaccaaa atatcaacct ctggatatgc 2739901 ctgaaacagc tcattgcagc cttcttctgt tcccaaatca aatgcagccg gataaagaac 2739961 cgcttcagca tgttgtgttt tcagttcatc tatcgtttga ttcactttct cttcccggcg 2740021 tccgttaatg atcactgccg caccttcttc agctaacgaa gaggcaatag cttttccgat 2740081 ccctgatgtc gaaccggtca ccagtgcggt ttttccttgt aaattcagct tcattattca 2740141 tccctccgtt tttgattcct cttatttatt gacagaaatc tgattggtga aacatctgct 2740201 ctgcaatcag tatgaaacag ctgggattga aatggaagta cgcacttttt ggtgcctgtg 2740261 gtttggagaa aaaataaagc agaacctctt aagaggttct gctttattgt cagtatgtat 2740321 ggagacggtg ggagtcgaac ccacgtccag aaacatcgat tacttaagcg tctacgagcg 2740381 tagcctgcat atttatggtt tcactcatct tcttgcctgc gggcgggcct tccgagagct 2740441 agtctgttca tctcttctta cgttctcaga cgggaacgca agcgtagcct acttggatgt 2740501 gctcttcaca gacacatagg caatgtcagg aagagctcgc tgcgcttatt aggcagctaa 2740561 tgctacgttt tggttaaaac tgttagtttt gccagttata tttaagtgcg tgtttacgag 2740621 atcgcctctc ggctcgcagc tcaagctcga tccatccctg tcgaatccgt aacgtcccct 2740681 tggtataagg gaaatacggg agaaaatatc aagctctcac tcaaactggc tatagtctta 2740741 ttataacatg atcacggctc ttttcaattg tcaaatcctt caaatgaatg gcgtcgtgat 2740801 ctgatcgtga acacagtata gcacaggcct gattttcgaa tcaagcacta tgcctttaga 2740861 agcctttttg actgtctctg aacgctcttt cgatttcccg cttcgcgtcc ttgcgcttca 2740921 gatcttcccg tttgtcatag ttcttcttcc cttttccaag gccgagaagc actttggcaa 2740981 agccgttttt taaatacagc ttcagcggaa cgagagaata gcctttttcc tttgttaacc 2741041 cgatcagctt attaatctcc ttgcggtgca ttaacagctt tcttgtccgg agcggatcgt 2741101 ggttatagcg gtttccctgc tcatatgggc tgacgtgcat attgtggaga aacacttctc 2741161 cccgttcgat tttggcgaag gaatccttaa ggtttacgcg gccggcgcga atcgatttga 2741221 tttcggttcc ttgcagaacg atgcctgttt cataggtttc ttctataaaa taatcgtggt 2741281 tggctttctt attttgagat aatacttttc ctgacccttt tggcatgcca gaacctcctc 2741341 tctctaagga aaaactgtcc accttttgcg atacgctcta ttttaccaaa tgtcacgtac 2741401 cgctacaatg aaaagctgtt tccgaaagaa agcaaataga gcgctgcggc cctatttgct 2741461 ggttgagctg ctatttcttc tttttccgtt tctgtttcgg agcattctgg aagccgcgtt 2741521 ttttcttttt cttcttcggc ttagtgaacc actccccttt ttcctcagac ggagctggag 2741581 aaacaggtgt attggtgctt tgaacacgtt ttctggcagg ctttccgcgt tttctgctcc 2741641 ggctgctgtc caattctctc ggacgccgcg gagtgccttt catgccgaca atttcaaagt 2741701 cgatattgcg ctcatcttta ttgacatcga caaccttgac tgtgatttca tccccgatgc 2741761 ggaagacgtt gcctgtccgc tcgccaatca ttgcgaaatg ctgttcgtca aagcggtagt 2741821 agtcatctgt cataaagctg acatggacga gtccttcaat tgtattcggc agctcgacga 2741881 acattccgaa gtttgtcaca gagctgatca tgccgtcaaa ctcttcaccg attttatcaa 2741941 gcatgtattc cgcttttttc agatcatccg tctcacgctc ggcgtcaact gcacggcgct 2742001 ccatagatga tgtatgttcg gcgatatccg gcaggcgttc agcccacttt tcctgtgtcg 2742061 cttcatcgac cttgccgttg atcaaatacg ttcggatcag acggtgaacg attaagtccg 2742121 ggtaacggcg gatcggtgat gtgaaatgcg tatagaattc cgttgacaga ccgaagtgcc 2742181 ccaagctttg cgggtcgtat ttcgcctgtt tcatcgaacg gagcataaca gtagatataa 2742241 ccgtttcctc tggtctgtca cgcacagcgt ccagaatgct ttgcagcgcg cgcggatgaa 2742301 tattccccgc cgttcctttc accacatagc caaatgtcgt cacaaattct aaaaactttt 2742361 gcagcttttc agcattcggc tcttcgtgaa tccggtatat aaacgggaca ttcatccaat 2742421 ggaaatgctc cgcaactgtt tcgtttgcta caagcataaa ttcttcaatc agcttctcgg 2742481 cgacagagcg ttctctgatc acaacgtctt taaccgctcc ttcgtcatca acaagcacct 2742541 ttgcttcttt gaaatcaaag tcaacggcgc cgcggtccat ccgcttatcg cgcagaattt 2742601 gagccagacg ctccatgtct ttgaacatcg gaacaagagg ctcgtatttt tgtttcagct 2742661 cttcatcatc atcaacaaga attttattca catctgaata tgtcattctt tccgttgttt 2742721 tgatgacact ttggaagatc tcgtgctctg tcacctgtcc ctgactgtta attgtcattt 2742781 cacaagaaag cgtcaggcgg tcaacctttg gatttaagga gcagatgccg tttgacaatc 2742841 tgtgcggaat catcgggatg acacggtcaa ccagatacac acttgtccct ctttcaagcg 2742901 cttctttgtc aatcggcgag ttttcggtta cgtaatggct gacatcagct atgtgaacgc 2742961 caagcttgta gcttccatca tcaagcttcg tcacggtaac tgcatcatcc aaatccttcg 2743021 catccgcacc atcaatggtg acaatcacct ggtcacggag atcacggcgg tctttcagat 2743081 ctttttcatc aatcgtgtca ggcgtacttg atgcctgttc catcgcgtca gctggaaatt 2743141 ctcccggcag gccgtgctta tgaatgaccg ataaaatatc aatgcccggg tcgtttttgt 2743201 ggccgagaat ggtttcaacc tcaccctctg cgttcatgcg gccttcagga tagctcgtca 2743261 gcttgacaac aaccttatgc ccttccgcag ctccattttt cccatttttc ggaatgaaga 2743321 tgtcactcgt gatttttttg tcgtccggaa tgacaaagcc gaagtttctc gtttctgtat 2743381 acgtgccgac aacccgctga atcgctcttt ctaaaatccg tatgacggtt ccttcctgcc 2743441 tggagccgct tgattgtgag ttcagacgca ccatgacgat atcgccgttc attgccgtat 2743501 ttagctcatt aggcggaata aacacatcac ttaacgacgt atcctcaggc agcaaaaagg 2743561 cgaatccttt cgcatgggct gaaatctttc cttttattaa attcatcttc tccggaatgc 2743621 cgtagcggtc gcttctcgtc cgtacgataa gccctttttc ttccaaggcg actaacgctt 2743681 tgacgagctc tttaaactcc tcggcttccg taatatttaa catctcctca agttcctgaa 2743741 cggtcagagg tttgtacgcc tcttccttca taaacgagag aagcttttcc ataaatgctt 2743801 ctttttccat tatccgacct cctgttgatt accaatcgag cttctctaaa aattcataca 2743861 catcctgatg gacgaggtca cgttctttgt cgagtgtaat gacatgccct gattcctcgt 2743921 accatttcag ctgtttatca tcagtttcca cttcgttgta aataatattg gcgctttcgg 2743981 tattaatcat gtggtcatga cgggcctgca ccacaaatgt cggtgaataa atcatatcga 2744041 cattattccg cacatcagca attaagtctt gcagcgcctt gagggtattc atcggcgttt 2744101 tttcgaattc tttcatttcc tcttcaattt gctccgggct tttcccctca aactttttgt 2744161 aattgcgagc gtatgaaaga acgccttgat acatgacctc ttcactctta atatgcatcg 2744221 gtgcgcacat tgggacaatt ccctttatgg gtacagtgta acccaatttc agcgaaaaaa 2744281 ccccgccaag cgacagtccg caggcagcaa tgctctcata accttcagat tttaaatatt 2744341 catagccatc cattacgttt ttccaccagt cttcgggccc cgtatgtaca agttcttcag 2744401 gcgggacgcc atgtccttca tattgaggcg cgtggcacgt atagccgcgt tcattcaaat 2744461 atcgtcccag catccttaca tccgctgtat ttcctgtaaa gccatgcagc aaaagcaccg 2744521 ctttgtctcc gcctttaaat gtaaatggtt ttggtgtcac aactttcatg ctcatgtctc 2744581 cctttctatc tgcacgatca ttttagtttt ccacagttta atcagaaaaa aacgttttga 2744641 atatcatcca gaaacgtgaa aaaggcctga cttcacatca gaccttatac aaacattgcc 2744701 ctataggata taagcaagcg caatcgttaa cacgaaaaac aagactgcca gcactaccgt 2744761 aatgcggtgc aaaattaaat caagacctct tgctttttgt ttcccgaaga gctgctccgc 2744821 tccgcctgaa atcgcaccag ataatccggc acttttactg gattgaagca aaacgacaat 2744881 aataagtgca atgctgacga taaccaataa ggtaatcaaa actgcgtgca tcccatacac 2744941 ctccagactc actggctaca ttacttctat tttacatgaa aagggttggc atgtcacgct 2745001 gtatcagacg ccaaaaggcc ggataagacg ttttatcttg gttaccctat tcatatgaaa 2745061 aggtcaaagg agaaaagcga tgccgcttat cagcatagac agcaggaaac atctttttta 2745121 tgaagaatat ggacagggaa tccctatcat ttttatccac ccgccgggca tgggacgaaa 2745181 ggttttttat tatcagcgcc ttctatccaa gcatttcagg gtgatttttc cggatttaag 2745241 tggccacggt gatagtgatc acatcgatca gccagcgtct atttcctatt acgcaaacga 2745301 gatcgcgcaa ttcatggacg ctttgcacat tgataaagct gtgttattcg ggtattctgc 2745361 cggaggctta atcgcgcagc atatcggctt cacccgcccg gacaaagtgt cacaccttat 2745421 tctgtccggc gcctaccccg ctgttcataa cgtaatcggc cagaagctgc acaaactggg 2745481 aatgtatctg cttgaaaaaa accccggttt gctcatgaaa atcctcgctg gcagccacac 2745541 aaaagacaga cagcttcgca gcatattaac agaccatatg aaaaaagcag accaggccca 2745601 ttggcatcag tattatctgg attcgcttgg ctacaactgc attgaacagc tgccccgcct 2745661 agaaatgcca atgctgttta tgtatggcgg cctgcgggac tggaccttta caaacgcagg 2745721 ctattaccga agatcgtgca gacatgccga atttttcaga ttggaatatc agggacatca 2745781 attgccgaca aaacaatgga aaacgtgcaa tgagctggtg acagggtttg tgctgacaca 2745841 tcattcatag gaatagaaaa cgcttggctt ccttgcgttt tttgttactt tattgacttt 2745901 tgtcaacgaa atcatagtaa aaaagatcct caaatttcaa attaaaatag tgaagcattt 2745961 taccaatcac aagctgcccc ggccttcttt ctccattcag cacgcggctc agtgtggcgg 2746021 gtgagactcc gatttccagc gcaagctgat taagggaata atcgttatta accatatact 2746081 gcaagacata atcacgtcta atctgtatct tttctactgg cactttcctc accttccatt 2746141 cctgaaaaac ttttttctat acttttacat tacggcttat gttaactttt gtcaatacat 2746201 ttccagtcta cctattccct ttagtcaata aacatactaa aatatgagta acagtgaggg 2746261 acggggtgag atatatggaa agctttggcg aacaattacg ggcattgcgt gaagagagaa 2746321 agttaacagt caaccagctg gcgacttatt caggcgtaag cgcggccggc atctccagaa 2746381 tcgaaaacgg aaaacggggc gttcccaaac ctgccaccat caaaaaactg gcagaggcct 2746441 taaaaattcc ttatgagggg cttatgtaca aggctggtta catcgaagaa gtgcatgaag 2746501 ccagggcccc ttatgaaacg aagtgcaagc tgcttgaaaa agcggaggcc tatgacctga 2746561 aaaaccttgc gcttcttgag aacgaaaagt ggcaatatct caataaagaa gatttgctca 2746621 tgctggatca ttatttttcg tttatttcag atgaagcgaa aaaacggtct gctgatgact 2746681 gactcttgat agaaatgtga ggcgatagac catgtcaccg ttcggacagc aattacggga 2746741 gctgcgccgc gcccgcaaac tgacagtgaa tcagcttgcg gtgtactcag gcatcagctc 2746801 ggccaccatt tcaaaaattg aaaacggcaa acgcgggacg ccaaaacccg ccacgattaa 2746861 aaaactggca gccgtcctga aagtgccgta cgaaaaccta atggccgccg caggccatat 2746921 tcaggccttt cctgaagaaa tccgcgaagc atctgaaggc tatcaatccg tttatgaaat 2746981 ttaccagacg gctgtcacac gcggagcgga gcacctcccg attttcaata gtcaaaaatg 2747041 ggaacatctc tcaaagcagg atattgaaaa tctcagcaaa tacttcgatt ttttgtcttc 2747101 agaagcaaaa aaacgcgcct cttcctcata atcccctgtt tctctttcta tattttatca 2747161 atcacgcttg catgccctcc ctcgttattt gcgttataat agtgacagac gaggtgaaaa 2747221 gtatgaacca atcagaaatg tgtcctagat ttgaaaaagc agtcgacatc ttaagtaaac 2747281 gctgggtcgc tttaatcgta tttcagctct tgaacgggtc gcagcgattt agcgaaattg 2747341 aagcagcact tccaaatcta agcggcagag ttctgtcaga acggctgaaa gaacttgagc 2747401 ttgaaggagt agtgaagcgg gatgtcatcc ctgaaactcc ggttcgcatc gaatattcat 2747461 tgactgataa aggaaaggca ctagcaccca tattaggtga gatttctaaa tgggcgactg 2747521 aatggattga cccttccttt cttgactaat tgctaaaatg gttctgatct caaagacgag 2747581 aaaagaaccg ttttttattt tccaggtgaa aaaaagatat ctcagccgat atatagtaca 2747641 tccacacatt acgtttttaa aggagaccac tatatgcgac tgacgatttc ccgcaaattc 2747701 agcctggtat ttttgacact gatcctgatc aatttacttg taggcggaat aggcgttctt 2747761 aatatgcagc atatcattca aaaaacagat gaaatcaaca caaaatggat tgacggcatc 2747821 aaaggaatca cttcaattaa ttatgtaacc gagcacctgt cttctaaaga aaaggacttt 2747881 ctgatttata cagacaaaag taaaatggat acacttgatc aagaaatgaa tcaaatcatg 2747941 gaagacatta accaaaagct cgataactac gaaaaaacga tctccactga taaagagcag 2748001 aaactgttcg agcagcttca aactaaagtg aatacctata tggatattca tgcgcaaatt 2748061 atcgaaagcg gccgcacgaa tgacatggac aaagcaagag gtttattggt tcagactgag 2748121 gccagctttg aggatatgaa aaaaacaatc actcagcttg ttgacttaaa tcaagaaggc 2748181 agcaacacag cggtaaaaga aacgaaggcc gtctatcata aagggctcat ttacactgct 2748241 ttgcttgtgg cagcatcaat cctcatcagc attttcatct ggctttatat cacgcgaaac 2748301 attgtaaagc ctatcattcg catgaaggaa tctgccaatc atattgccga aggcgatttg 2748361 tcgaacgata tggaggccct caactcaaaa gacgagctgg gtgatctgaa tgaagcgctg 2748421 caaaaaatgg tagggaatct gagagatatt gtcggatatt ctaaagacat atcaagccgg 2748481 gttctttctt cttcacaggt gcttgcaacc gcaacgaatg aaacaagatc cggcagcaaa 2748541 catattaccg agacgatgaa cgaaatggct gagggctctg aacagcaggc ccaagacgcg 2748601 gtgacgattg ccgaatcgat gaatgagttt accgaaagca ttgataaagc ctataatcac 2748661 ggcatcacaa tcagcgatac gtctcaaaac gttctcgaac tcgcggtaag cgggaacgaa 2748721 aatatggcta cgtcattaca gcaaatgaaa accatccatc atattgttga agaagccgtg 2748781 cataaagtga gatcactgga acagcattct caggatatta acaagctcgt tcaggtcatc 2748841 aacgggattg ccgagcagac gaatttgctg tcccttaacg ccgcgattga agctgcccgc 2748901 gctggagaaa gcggcaaagg cttcgccgtt gtggcagagg aggtcagaaa gctggctgac 2748961 ggcgtttctg attccgtgca ggacattacc cggattgtaa acgggacaca gcaggagatc 2749021 cacactgtca ttacgtactt ggaaagcagc tttacagaag tcgaaaaagg aacggaaaac 2749081 ctgacagaca ccggacaggc tatgcagcat atcaaacaat ccgtcaccca tgttgcagac 2749141 agcattaagg aagtaacgga tggcttgaag cagttaacaa accaatcgat taccatcaat 2749201 caatcgattg aaaatatcgc ttctgtatcc gaagagtctg ccgccggcat tgaagaaaca 2749261 ttttcaatta ccgagcaatc cgcccattcg atggatcaag tgcttctaaa tgctgaagag 2749321 cttgagcagc tggccaatga gcttaatgag aagatgggtc agtttacgat ttaaagagaa 2749381 aaaagaggct ggactccagc ctctttttct attctatgca gctgattgaa catgtttcgc 2749441 cccggttctt tttttcttca ccggacttaa tgcccgctcc agccaagcca tgagcaaatc 2749501 cgcccctacc gccatcaccg cagttggtat cgctccggct agaataatcg cagttccgtt 2749561 tgttgcgttt gagccgcgta cgatcatgtc cccaaggcct ccggcaccga caaatgtgcc 2749621 gatcgctgta attccgatgg caatgacgag agccgtgcga aggcccgcca taatgacaga 2749681 aagtgcgagc gggagctcaa ccattctgag cacttggaat ttcgtcatgc ccattgcttt 2749741 tccagattct aagtaggcat gttcaatact gataatgcct gtgtacgtgt ttcgaataat 2749801 cggcagcagg gaatacagaa ataatgatag aatcacggta tttgcgccga gccccataac 2749861 aagcattaag acggccagca tagcgagcgc cgggattgtt tgaataacgt ttgttacggc 2749921 aaacacccag gctgacaaac ggcgaaaatg cgcgatgagg attccggccg gaaccccgac 2749981 gacagcggca aataaaacgc cgtaagccga catgagaaag tggcggccga attcatccat 2750041 gacgtaactg ccattctgcg cgtaatacgt cattaactgt tcaagcacgt tcattgacct 2750101 cttccccctt tcacgattcg aaatagcgat gtttttctaa atattccttg gcaacgacag 2750161 acggttcttt gagattgccg tcgacttcat agttaagctc ctgcatcgtg gctgtgtcga 2750221 tttttccgag cattttcttg atgatgcctt caagttcagg atgttctttg agcacctttt 2750281 ccggaacaac cggagagcag tcgtacggcg ggaaaaattg tttatcatcc tttagcattt 2750341 tgagaccata ggacttgatt cttccatcgg ttgaatacgc aagcacaatg tccatttttc 2750401 cgcttttcac cgcgtcgtac acaaggccga tctgcatcgg atacgtgccg ccgaatgtca 2750461 tgccgtaggt tttcgtaaaa tcctgatagc cgtttccttt gagcttcatc caatagttat 2750521 caacgcccag ctttaattgc ggcgcccatt ttttaacgtc tgatacggtc tctaaatggt 2750581 attggtcggc cagctccttg ctgactgtaa aggcatatgt attatcaaac ccgtaggagt 2750641 cataccactt taaatcatat ctttttttaa actcccgctg agtaagcgcc agcgctttgt 2750701 ccggatcttt ttcaggttcc attctcaacg tgcctgtcag cgcgtctccc gtatatcttg 2750761 tggccgcaat gtcgatttcc ccgttcatta aagcctgctg ctgcaccgcg ttggagccaa 2750821 gatttttaat cgttgttgtt ttgagatcag tatggtgttc gatcaactgg ccaagcatgc 2750881 tggcgatgat ttctgattcg ctcatgcttt gcgcgccgat tttaatggtc tggtctgcag 2750941 cagcgctgag accaggaagc gaacagccgc tcagcgtcag cgttgccgca agtgctaaac 2751001 ctatcattaa tttgagatat tttcttttca tgagccgcct ccttatgaca attccttcaa 2751061 tctctgcatg ccggcaggtg tcagttttcg ttcagcaact gccagcacat aatcaatcac 2751121 aattgccaat atcgtgacag gtaccgcgcc cccgatgata tattccggct gatataaatt 2751181 cagtccgata aaaatgtaat cacccaatcc gccgcctccg ataaaggaag caagcgtggc 2751241 ccagccgatt aagtaaatcg tcgatgttct gattcccgcc atgatcactg gtgcggcaag 2751301 cggcagctcc accaagcgga cttgttcagc cggcgtcatt cctattcctt taccagactc 2751361 gagcagattt ttgttgacgc cgcgaatgcc ggtatacgtg ttgcgaagaa tcggcaatac 2751421 ggaatagaaa aacaaagcca caatggccgg aaccttccct acaccaagga gcgggataaa 2751481 aaaagcgagg atggccagac tcggcagcgt ctgaatgata ttgacaatgc cgataatggt 2751541 gccggctcct tttttcattc tggtaagcac aaccccgagg gggacggcaa ccagcacacc 2751601 taagatcaca gcaatgagcg atatcgtaat atgctcgtat gttttataaa gaagctctcc 2751661 cccattggtt tgcaaaaatt gaacaatatg atgcatgact tatcgcccct ccctatgaca 2751721 atgctgcgag ctgcttttct tctccccaga gggagtcata cacgatgtcg accagacttg 2751781 ccctcgtcac aattccgatc aggcgtcggt cttcatccac aacgggaaca tatttgacac 2751841 cccgttttaa aattttgcgg accgtgtcgc gcagcagtgt gccgcccagt actgtgtata 2751901 tatcttcatg taaaacttca ctgacgagat tggccttttt ccggcattga tcaatgattt 2751961 caacatcgac atagccttgc agaacgcgct cgtcattgac gaccagcaat gaatcgaccc 2752021 gttcctgcct catcagctga atggcctcag aaagcgtttt atccgcggtg atcgttacag 2752081 gctgtgtgtt cataatctgg tcaacccgtt caacatccgg gctggatgac tgaatcagcc 2752141 gctccttgcc gataaattcc tcaacaaatt cgtctgccgg atttcttaaa atgtcatcgg 2752201 gcgttccaac ttgaacgatt tctcccgctt ttaaaatcac aatccggtct gccagcttaa 2752261 tcgcttcatc catatcgtgg gtaacaaata cgatggtttt atgtaaggtt ttttgcagtt 2752321 ttttaaattc ttcctggagg gaatccctcg taatcgggtc gagtgcccca aacggttcat 2752381 ccattaagat aagcggcggc tccgcggcaa gtgcccgtaa tacaccaatt cgctgctgct 2752441 gccccccgct taattcatga gggtaacggt ctacatattc tggccccata tcgaccaatt 2752501 ttaaaagctc acgcgcccgc tctttccgct gctgctccgg ccatttcagc agttttggga 2752561 cgagtgagat attctgctga atggtcatat ggggaaacag gccgatctgc tgaatcacat 2752621 agccaatttt gcgcctgagc tctacaggat cctggtccat gatgttttcg ccgtcaatga 2752681 aaatcttccc ggcggaaggc tcaattaatc ggttaatcat tttcattgtt gtcgtttttc 2752741 cgcagccgct cggcccgata aagcagataa attcgccttt tgcaatctta agatttacgt 2752801 tgttcacggc ttttttgccg cccttgtatg ttttcgagac attttctaat gtcagcaaac 2752861 atcgcacctc caaaattaag tttattcaat ttgttcagtt taaatttaat ttttcagaca 2752921 attgaatgct tcccattata gaataaagtt tataaaataa aaagtttaca atttgttcat 2752981 attatttata aagtatgtgt aaacgctgat ttacccgcat tgacgtgtgt tgatctcctt 2753041 attgctccaa tttcctgcca aattctcttt tgacagcatt ttcgccgtat caaaaatgtg 2753101 gtatattgac atcggaattg ttagctgaaa ggatgaaacc gttggagaaa gatccgttaa 2753161 cgatcattga acaagccgag gaccatttta tagaaagaat cgcggaaaac atgcatgcat 2753221 ttggaatgcc ctctaccgtc ggacgagtgc tgggcattat ttatatgaat cgaaaaccga 2753281 tgacgcttac ggaattatct gaggccaccg gcatgagtaa aacacgtatg agccaggtag 2753341 tgcgggaaat gcttgatgcc aacattgccg agaaggtatt cgaaaaaggc gtgcgaaaag 2753401 atttatatga ggttgagcag gactactatc aaacatttat cacgctgttt tcagccacct 2753461 ggagcaaagt cgtcagcaaa aacaaaatga tgcataaaaa actcaatcgg gagctgctta 2753521 gcgtgttgga tgaagagctt actcctgaag cggaagaaaa agtgaatgag ctgctgaagg 2753581 aattaaagga atggctcgat tattataatt ggctcagccg tttgattgag ttttttgaga 2753641 gcgaagacat ttttaaatat gtgccgaagc cgtaaaaagt tcccaaattc aattctggga 2753701 acttttttaa gtccaatcca aatggttgaa tatcaaactt cgagctccca acgctggaaa 2753761 atatgtttaa cagatactaa cacatgttgt ttatttaaaa aaaccacctc tgttgtattt 2753821 aaatagaggt ggtttttcta tcagctataa taaaatttcc ttttttcttt ttaatcgggc 2753881 ttaatgctcg ttcaagccag cccatgacca aatcggcaat caccgccatc agagctgtgg 2753941 ggatcgctcc cgctaatata atcgcggttc cgtttgtggc gtttgatcct ctgacgatga 2754001 tgtccccgag accgccagca ccgacaaatg tcccgatggc cgtaatgccg atcgcaatga 2754061 caagcgcggt gcgcaggccg gccattatga cagaaagcgc aagcggaagc tcgaccatcc 2754121 gcagcacttg aaattttgtc atccccattg cttttcccga ttcaagatag gcgtgctcaa 2754181 tactgataat ccctgtatac gtatttctga taatcggcag aagagaatac agaaataatg 2754241 acaatatcac cgtattagcg cccagcccca tgacaagcat cagcacggcg agcatggcga 2754301 gagccgggat ggtctgaatg acattcgtga ccgcaaaaac ccatccgctt aatcttctgt 2754361 atctggctat caggatgccg agcggaattc caacaatggc ggcaaataaa acgccataca 2754421 ccgacatcag aaaatggcgg taaaattcct gcagcacgta accgccgttt tgcgaatagt 2754481 atgtgccaag ctgctgtagt acttccatat gatccacctc ttttcttagt caaaataatg 2754541 atgtttctct aaaaattcct ttgctacgac agacggctcc ttcagcttgc catccacctc 2754601 ataattaagt tcctgcatcg tttccgtgtc gatttgccca atcagcttat tgatcacacc 2754661 ttcaagttcc ggatgctcct taagcacctt ttccggaatc accggtgaac agtcatacgg 2754721 cggaaagaaa cgcttatcgt cttttaagat tttcagatca tatgctttaa tccgtccatc 2754781 cgttgaataa gccaaaaccg catccatttt cccgtttttg actgcgtcat agactagccc 2754841 gatctgcatt ggataagttg tgccgaactc aaagccatat gtgctgacaa agcctttata 2754901 cccgtcgcct tttcgtttca gccaagcatt gtcgacgcct aatttatatt gggaagcatt 2754961 tttcttcagg tcagacacgg tgttaatatg ctccttttcc gcaaactttt ttgttacggt 2755021 gaaggcatat gtgttatcaa agccgtagga atcaaaccat ttataagaaa agcgcttttg 2755081 aaactcgttc tgcacaatgt tcagcgcttt tttcggatct ttctccgctt ccttgccgag 2755141 ggtgcttgtt aaatctgttc cggaatagcg cgtggctgaa atatcaatgt caccgcccag 2755201 catcgcttgg tgctgaacat agtttgagcc gaggtttttc actaaagcag tattcaaatc 2755261 tgtatcatgt tcaataagct gcgcgatcat attcgctaca atttctgatt ctgtcatgct 2755321 ctgcgccccg attttgatcg tatcgtcaga agcgccgcct agacccggca gagagcagcc 2755381 gcctagcagc atgacaaaga cgagagcaaa cgcgccaagc catttgattt ttgtcatttt 2755441 caacagtgcc aactccttac gatacttcct tcatcccttg caagcctttc ggcgtcacct 2755501 ttcgttctgt cacagccaga acataatcaa taataattgc cagaattgtg acaggcacgg 2755561 caccgccaat gatatattca ggctggtata ggttcagtcc gataaaaata tagtccccga 2755621 ggccgcctcc cccgataaac gacgcaagtg tcgcccagcc aattaggtag atcgttgatg 2755681 tgcggatccc cgccatgatg atgggaatcg ccagcgggat ttcaacgagc cgaatctgct 2755741 cccagccggt catgccaatt cctttccccg attccaggag gtttttattt acacctttaa 2755801 tgccggtata cgtattgcgc aggatcggca gtaccgaata gaaaaataaa gcgacaatcg 2755861 caggcacttt tcctacgccg agaagcggaa taaaaaaggc taaaatcgcc agactcggca 2755921 gggtttgcac aatgtttacg aaaccgataa ccgcacctgc gccttttttc attctggtaa 2755981 gagcaacgcc gagcggcact gcaacgataa tgcccaatac aacggctatg agtgaaatat 2756041 ataaatgctc tcctgtttta tacagcagct ctccgccgtt cgtttgcaaa aaagtcatca 2756101 tttgattcat cttaaaagag ctcctcccct ggtcagatcg tcatgagctg gttttcctcg 2756161 tcgccccaaa tggaatcgta tacgatatca acgaggctcg ctcttgtcac aatccctgct 2756221 aaatggttct gttcatcgac caccggaaca tacttgatcc cctgcttcaa aatttttcgg 2756281 actgtatcgc gaagaagcgc ccctttttga acggtatata tatctgaacg gtatacatcg 2756341 ccaacgatgc tcgctttttt gcggttttga tcaatcattt ccacatcaac atagcccttc 2756401 agcacgtttt gccggtccac aacgagcagc gagtcaacac gtttttctct catcagctga 2756461 atcgcctgag aaagcgtttt gtccgcagat accgtcaccg gcgttctgtt catcatttgc 2756521 tctacccgct cgatatccgg tcttgactga atcaggcgct ctttcccgat aaattcttca 2756581 acaaactcat ttgccgggtt tcgaagaatc tcatcaggtg tgccgacttg aacgatttct 2756641 cccgctttta atatcacaat cctgtcagca agcttaatcg cttcatccat atcgtgggtt 2756701 acaaacacaa tcgttttgtt taaggttctc tgcagttttt tgaattcttc ctgaagggaa 2756761 tcacgcgtaa tcggatcaag cgctccgaac ggttcatcca ttaaaatgag agggggttcc 2756821 gctgccaggg cgcgcagcac gccgattctc tgctgctgtc cgccgctgag ctcatgcgga 2756881 taacggtcta aatactctgg gcccatatcc acaagcttta acagctcgcg cgcccgttct 2756941 ttccgttttt cctcaggcca tttcagcagc tttggtacga gtgagatgtt ctgctggatg 2757001 gtcatatggg ggaacaaacc aatctgctgt atcacatagc cgatttttct cctcagctca 2757061 accgggtcct gttccataat attttctccg tcgataaaga tccttccaga cgatggttct 2757121 atcagtctgt tgatcatctt catcgtcgtc gtttttccgc agccgctcgg gccgataaaa 2757181 cagataaatt caccttttgc aatatctaaa tcaatgctgt tcacagcttt tttgccgcct 2757241 ttatatactt ttgacacttg ttccaatttc agcaatccgt gcacctccgc aggtttcctt 2757301 taaattttct gaaaagtata atccttatta tagtttgaac tttgtaaaat aaaaagttta 2757361 caatgtgttg aaattatatg ttatttatag attatttatt gttatgaccg agacggaaag 2757421 ggtgttctta caattactcc ggatacctcc cacttcctct gcattcagct attttcaaca 2757481 ccaggaagaa atatgatata ttgacaccat caattgccat ttgaagggat gatcagctgt 2757541 gaaaaaaacc gctctcgaca tcattgaaca tgctgaagag catctcattg agaagattgc 2757601 cgaaaatatg catacgtttg gaatgccttc aactgtcgga cgtgtgctcg gaattattta 2757661 tatgaatcga aaaccaatga ccttaagcga gctctctgag gcaacgggca tgagcaaaac 2757721 acggatgagc caggttgtcc gggaaatgat cgatgccaat atcgccgaaa aggtgtttga 2757781 aaaaggcgta cgaaaagacc tttatgacgt cgagcaggat tattatcaaa ccttcatttc 2757841 tttatttgcg gcgaattgga caaaggtcgt gagcaaaaac aaagtgctgt ataaaaaatt 2757901 aaaccgggag ctgagtgatc ttttacaaag ggacgggctt accccggaag cggaagagaa 2757961 agtcaatcag ctgctgaatg aattaaaaga atggcttcat tactatgatt ggctgagcag 2758021 gttgattgaa ttttttgaga gtgaggaagt ctttcggtat gtgccgaaaa caaaagaatg 2758081 cagctctcta aaataagaga gctgcttttt gcatcatgaa gttaagaccg gaaacatgcc 2758141 tttcagcccg gcaccaatca tcccgaccgc aaccacggct aagattaatc ccatcagtct 2758201 ggtaatcaca ttcatctcgg tttttccgag tttgctgctg ataaaagcag aatagtggaa 2758261 aaagagaaag gtcagggcaa taacggcggc tatgccgatc atgacagccg cataatgacc 2758321 aatgccgcta tgtccggcgg aaaggctcat cactgttgca atcgttccgg gcccagcaat 2758381 gatcggaatg gataaaggtg tgactgatat atccgctttt tccttgcttt ccttatgttc 2758441 atcatggtga agagattgca cgtgcgattc tttcgcattc aatagattat aggcaatgcc 2758501 gaaaatgaat atgccgcccg ccactcggag cgcgtgaatg ttgatatcaa acagtttaaa 2758561 gataagatga ccgaaaacca aaaaagctgc gagaataaaa aaggataaaa tagctgcctt 2758621 ccgggcaatc gcttttcttt ccgctgcagt atagccttct gtcagcgtca gaaatatcgg 2758681 tacgtttccg atcggattcg atactgcgaa taaagaaatg aagacgtgaa cgataaatga 2758741 gaacatcata tacctccttg ttgatagtct ctgcacagga aatagaatga ttctccaccc 2758801 ttttacccgg aggcgatttc ccggtaaacc tttatagcct gtcagaaacg cgccatgcta 2758861 caatgaagtg acaaattgaa taggaaggac gtatacagat gttcaaaaaa attgcggcag 2758921 atgccttggg cttatctgat atcggaaaaa ttatcgaacc tcaggactat gacaaaacag 2758981 acgcagatga ctatgtcatg catgaagata atgagaaaat ttatttcttg attaaaacaa 2759041 aagcagacga gtattgcttt acgaacctgg ccctgatcca tgtggacggc gaacgcgcca 2759101 cttcctcaaa acgaacgttg aaacgctatc cttattcgca atataaaatc tctgacgttt 2759161 ttcttgaaac tgccggaaaa gtggatttgg atgttgaaat taagttcaag ctgggcggtg 2759221 aacaattcga cattgatgtc cacaaagacc agattgaaaa gttaaaagac ctttataaag 2759281 cactgcttcg catcgctgaa acaacctatg aaaatgacat tttaatcaat caagcggagc 2759341 aaagcttaga taaagcagtg acgattcttc accatacccg ccctgagcac gtcaatattg 2759401 aaacgcaata caaagagctg accgaattcg gattcacttg gctgacatcc gttcgctcgc 2759461 agtatcatat taaggatttt ggggatgtat ttgagaaata tattaataac tagataaaaa 2759521 aagacacagc tgctatcgtg ctcgtgtctt tttttgtatg aatattgatt actttacaac 2759581 ttttttcttt tataataaaa ctattagtct attttcccta tattacagat aaaggagtta 2759641 ttttatgtat tgtcctcaat gcggccatca aacagatggc ggaaattttt gtgagaaatg 2759701 cggatcaccg ctccccggtc aatcaggcca ccagcatgca gctcaaactg gagccgctgc 2759761 aaagcaagca gcaaaacagt tcggttcatt tgtcttatcc gtcctgaaac gcccttatca 2759821 ggaatgtaaa gcaacaggcg gagaacagct gatcagcgca atcattacga tggttctttt 2759881 cagtttgctg acccctttga tgttttatat tcttttttca gacggtcccg gaagcgtaag 2759941 ctttacagca atcttcttag agccaaccat ttattttatt ttatttctat ttggcctgca 2760001 tgcatgcatc tttttcgccc tgaaaatcgc gggaaaccaa gtgtctttca aggattcatt 2760061 ctcaagattc ggagcatttc ttattccttt tacggctatt ttgattcttg cccttttctt 2760121 ctttttatta catacagaca tttgctttac catattagcc gttggtttaa tcggtgcatt 2760181 cttcgccatt cctcctgcga tgctgagcag ttaccagcat tcatataaag ggaaggttga 2760241 tttcatttac tcaacgattg tgatttatct gatcatctgc gttacatttc agcttattat 2760301 cgaacactat gtcaaagaaa ttttccgtta tatgctcttt taaaaacaac cccatcacct 2760361 gctggtgatg gggttgtttt attgaataga cgttaagtaa attcttccgt tcttcactac 2760421 gccggtgtag gtccagttat atgttctgag ctttggactg ccgcctgatt ttgtgatata 2760481 gaattcttca tacgtcttaa tcgtgatagc cgacccattt tggctccagc ttttcacttc 2760541 atagttatta aagtcttctg ttgtcccctc tttatttaat ttcgacacga gatgctgctg 2760601 gtcggaataa agggaactgc ctttttcaag gctgtcttcc atcagtgaga aattattttg 2760661 attcacggca tctgcctgac tttgcagata actgcccata aataatgtca cttgttcatc 2760721 tgtaacatcg ccgcttgcag agctttcact gcctttgttt ttcgagccag cccaggcgga 2760781 agtgtatgtc tctggtttat catttttgat tttctttata tttgtgcctg cagattcgaa 2760841 tgttgattct gcatcttcga aaatccactt tttctgtttt ttatcatatg aaagaagata 2760901 ttcataactc ggactgtcgt cagtcatttc agactttgta tagtcgttat acgaagaaga 2760961 ctggtgaagt tcttttcctg ttaccgatac ctgccacgtt ccgtcgtttt tctgagagag 2761021 ggcaaatgtg tccaggtcaa aatcagtttc caagtatcta tcttttaagt atgaatccgc 2761081 gcttttcata gaatcgacgg tgtccttcgt ctccgccttc caattggcac ttgcctctgt 2761141 catctgggct gtattcccat cagatagagc tttggagtat tgttttgttg ttttgacaat 2761201 tgtgttcata atctgttcct gtgtatcttg atcaggaatt aacgttaact ccatttcttt 2761261 atcatcgatc ggaacgccgg cagtttttgt ttttccccac ggaaattctg cctcgactga 2761321 agctgtcatt gatccatctg tcagcagcgg accatatgtt acggatttga acggatcttt 2761381 atgaattgat ttaccgttaa tcagcaaatc tcccttcccg ctcttgatgt cattcgctaa 2761441 gctgaatgtc acatcgtctg cttccaatga gagatcaaca cgaaagctgc tatcgccaat 2761501 cgcctgaatg tcttcctttt tcacaaggtc aacgacatcg tttttcagtt tggctgagac 2761561 tgtatattcg ccgggaatgt acggaccaag ggtttgtgct tgatctgctt tctttacaga 2761621 tccggcttcc tctttattga catatagatc ggtattttta taattgctgc tcacttcaaa 2761681 ataaacaggt gctaccttta agtcataatg gtcaaatacc agcaggcttt tcccgtcttt 2761741 ttccgcatat acgatatcct tctgggctgt ttcatcacgc agcgatgcaa aaagttcatc 2761801 ttttttgtct ggatgatcct tcaaatatgt aagaaacggt tttacattat ttttagtgag 2761861 tttaagattg tcatttaccg gtgtaagcag agtcgcgatt tggtcctgat ccccatcatt 2761921 tacggcctgt tcaaacttgt ctactaacct atcctttgaa gtaaaatacg ctccggtttt 2761981 atatgcggcg aataatataa cgcacgccgc ggcaatgctg ctccataaaa tgatggtttt 2762041 cttagggatc ggttttcgcg gagcctgcct cgtttctgca gtgctagctg tttcttgatt 2762101 tgcctgtttg ctgccccctc cgatcggggt gccgcattgt ttacaaaact tggctccttc 2762161 attattctgg gagccgcaat tcttacaaaa taacatgact ttcctcctat tctactaatt 2762221 tgataacatt tactgctttt catattttat aataaaacag aatgaaattg ggaacgaatg 2762281 aaaaaattaa atgtctatca gactaaaaag gtggaatgaa tatgcaaaag ctcaggattg 2762341 aattaggaga agaaacaaat gacgaattat atgatctatt gctgctcgcc gatccatcga 2762401 aagacattgt agatgaatat cttgagaggg gagaatgtta cacagcttgg gccggtgatg 2762461 agcttgcagg ggtttatgta ttgctaaaaa caaggccgca aacagttgaa attgtaaata 2762521 ttgcggtaaa agaatctctt cagaagaaag gctttggcaa acagcttgta cttgacgcca 2762581 tcgaaaaagc gaagaagctg ggggcggaca cgattgaaat cggaacgggg aattcgagca 2762641 ttcatcagct ttccctctat caaaaatgcg gattccgcat tcaggcgatc gaccacgatt 2762701 tctttctcag acattatgat gaggacattt ttgaaaacgg gattcaatgc cgcgatatgg 2762761 taaggcttta tttggatctc tgaaagcata aaaaagccgc cgagagaaaa tcccggcggt 2762821 ctttttatta cttgtttaag ttgtagaaag agttgatacc gtggtattga gcagtttcag 2762881 ccaactgatc ttcgatgcga agaagctggt tgtatttcgc aacacggtcc gtacgagacg 2762941 gagcacctgt tttgatttgt cctgcgtttg ttgccacagc gatgtcagcg attgtgctgt 2763001 cttcagtttc accagaacgg tgagagataa cagctgtgta gcctgcgcgt ttcgccattt 2763061 cgatcgcatc gaatgtttca gtcaatgtac cgatttggtt tactttgatc aggatagagt 2763121 tgcctacgcc gtttttaata ccttcagaaa gttttttcgt gtttgtaacg aagaggtcgt 2763181 caccaacaag ctgaactttt ttgccaagac gctcagtaag aagcttgtgg ccttcccagt 2763241 cgttttcgtc aagtccgtct tcgatcgaga tgattgggta tttagaaaca agctcttcat 2763301 accagtcaac catttcagca gatgttttca caacgccttc gccagacaga tggtatttgc 2763361 cgtcttcttt gttgtagaac tcagaagatg cagcatccat agcaagttta acttcttcgc 2763421 caggtttgaa gccggctttt tcgattgctt caacgattgt ttgaagcgct tcttcgttag 2763481 aaccaaggtt tggagcgaat ccgccttcgt cacctacagc agtgtttaag ccttttgcgc 2763541 ttaatactga tttcaggctg tggaagattt gagcgcccat gcgaagtgct tcacggaagt 2763601 taggagcacc tacaggcatg atcatgaatt cttgaatatc cacgttgtta tcagcatgct 2763661 ctccgccgtt tacgatgttc atcatcggta caggaagcgt ttttgagttg aatcctccaa 2763721 ggtattggta aagaggaatc tgtaagaaat cagcagcagc acgcgcacaa gccatagata 2763781 cgccaaggat tgcgttcgca ccaagtttgc ctttgttttc agtaccgtca agctcgatta 2763841 aaagctgatc gattgcgttt tgttcagtta catcaaagcc aagaagctct ggagcaatga 2763901 tttcgtttac gttgttaaca gctgttaaca cgccttttcc aaggtaacgg tctttgtcgc 2763961 cgtcacgaag ctcaaccgct tcgtattcac ctgtagaagc tccgcttggc actaatgcgc 2764021 ggccgaaagc tcctgtttct gtatatactt caacttcaac tgttgggttg ccgcgggagt 2764081 ctaatacttc gcgtgcataa acatcaacaa tgtatggcat gagttttgtc tctccttttg 2764141 attttcaaat tatttttgaa ttaaagatgt tcctgtcatt tctttcggtt tttcaacacc 2764201 aagaaggtct aataacgttg gtgcaaggtc gcctaggatt ccgccttcac gcagcgtaat 2764261 gccttctttc gttacaatca cagggactgg gtttgttgta tgcgcagtgt gcggttcgcc 2764321 tgattctgta atcagaatgt cagcattacc gtgatcagcg gtaatgatag cgtgtccgcc 2764381 tttagcaagg atcgcgtcaa cgacttcgcc caagcattcg tccactgctt caattgcttt 2764441 aattgttggt tcaaccattc cggagtggcc gaccatatca gggtttgcga agttaagaat 2764501 gatcgcgtca tgcttgtcag cttcaatttc tttgacaagc gcgtctttca cttcatacgc 2764561 actcatctca ggcttcaagt catacgttgc aactttaggc gagttgatga gaatacgctc 2764621 ttcacccggg aattcagctt cacggccgcc gctcataaag aacgtgacgt gcggatactt 2764681 ttcagtttct gcaattcgaa gctgttttaa cccgtgctga gataatactt ctccgactgt 2764741 gttatcaaga tttatcggtt taaacgctac atagccgtca actgtttcac tgaagtgagt 2764801 caggcagacg aaatacaggt tctttggata attctcgccg cggtcgaagt cacggaagtc 2764861 tttgtttgtg aacgtgttgg aaatctggat ggcgcggtcc ggtctgaaat tatagaaaat 2764921 cacagaatcg ccgtcttgga ttttcgcaac aggctcaccg ttttcttttg tgatgacaga 2764981 tggaatcacg aattcatcgt agataccatt tgcatatgaa tcatcaacaa catccagggc 2765041 gctgcggtaa gatgggcctt cgccgtacgc cattgcgcgg tacgcttttt ctacacggtc 2765101 ccagcgtttg tcgcggtcca tagagtagta acgtccggaa atgctggcga tttcacctac 2765161 accgatttcc ttgatttgat cgttcaactg gttgatgtac gttttcgctg tctgcggacc 2765221 tacatcacgg ccgtcaagga agccatggat ataaaccttt gtcagccctt cttttttcgc 2765281 aagctttaac agtgcgaata aatgattgat atggctgtgc acgcctccgt cagataaaag 2765341 accgaacagg tgcaaggctt tgttgttttc tttcgcgttg ctgatcgcgt caaggaatgt 2765401 ttgattgcgt tcgaactctc cttcacgaat ggcaacattt acgcgtgtta agctttggta 2765461 cacaatacgt cccgcaccga tatttaagtg acctacttcg gagttcccca tttgcccttc 2765521 aggaagacct acagcctcgc ctgaagcagt caaagtttga tgaggatact ggttccaata 2765581 gcggtcaaaa ttcggttttt tcgctaaagc gactgcgttc cctactgttt cgttacgtaa 2765641 tccgaaccca tcaagaatga tgagtgcagc tggtttttta ctcatattga ccttcctcca 2765701 ataattgaac gaatgactgt ggctcaaggc tcgcgccgcc gaccaaagca ccgtcaatat 2765761 cggactctgc catatattct ttaatgtttg caggctttac gcttccgcca tattggatgc 2765821 gaagcttgtc tgcagcttct tggctgaagc tttcagcgac ggttttacgg atatgcgcac 2765881 acacgtcatt cgcatctttc gctgtagaag atttgcctgt tccgattgcc cagattggct 2765941 catacgcaat aacagaagca gcaacttgtt cttcagaaag accagcaagg ccttttttca 2766001 cttggtcagc aacaagatca tttgttttgc cggcttcacg ctcttcaagc gtttcaccta 2766061 cacagatgat cggcacaatg ccgtgtttga aagctgcgtg tgcttttttg ttaactgttt 2766121 catcagtttc agcgaacatt tcacggcgct cagagtggcc gatgacgcag tagtcaacgc 2766181 caaggtcttt cagagcaacc gggctgattt cgcctgtgaa cgcgccgctt tcttcgaagt 2766241 gcatgttttg agcgccgact tttaggtcag tgcctttcac agcagaagca agcttttcta 2766301 agaaaagcgc tggcgcgcaa acaacagctt cagctttgtc tgctgctgga atggaagatt 2766361 tcacttcttc aacgaagctg acagcttcgc cgagtgtttt gttcattttc cagttaccgg 2766421 cgataattgg ttttctcatc tgttccactt ccttatagca gttttgagat tatttatcgt 2766481 tcagtgcagc tacccctgga agctctttgc cttccataaa ctcaagggat gcgccgccgc 2766541 ctgttgagat gtggctcatt ttgtcagcaa ggccgaattt ttcaaccgct gccgcagagt 2766601 ctcctccgcc gatgacagag tatgtatctt tcgcctctgc caatgcttcc gcaaccgctt 2766661 ttgttccttg agcgaacaag tcgatttcga atacgcccat tggtccgttc cacacgacaa 2766721 gtttgctgtt tttgatgacg tcagcatacg tttcgcgtgt tttcgtacca atgtcgattg 2766781 cttctaaatc actagggatt tcagagatcg gcacaatttt cacgtttgca tcgttagaga 2766841 aatcatctgc aacgagtaca tcttcaggca tgtagaagtt aacgcctttt tctttagcgc 2766901 ggtccataaa tgatttcgca agctcgattt tatcctcttc aagaagagat ttcccgactt 2766961 catagccaag cgcttttacg aaagtataag caagacctcc gccgatgatc aggttgtcta 2767021 ctttatcaag aagactttcg attacaccga ttttgtcttt tactttcgct ccgccgatga 2767081 tcgctgtgaa cgggcggtca ggattggaaa ccgcttttcc aagtacatca agctcttttt 2767141 ccattaagaa acctgcaact gctggcagat gctcggcaat tccagctgta gatgcgtgag 2767201 cacggtgggc agcaccgaat gcgtcattta catatacatc tgcaagctca gcaaatgctt 2767261 ttgcaagctc aggatcattt ttctcttcac caggatagaa acgtacgttt tccaatacaa 2767321 gaacgtctcc gtccttcatc tcagaaattt gtgcttttac agcatcgccg tatgcttcat 2767381 ccgctttttt cacttctttg ccaagcagtt cgccgagacg tgcagcgaca ggagttaaac 2767441 gaagctcctc aaccacttcg cctttcgggc ggcctaagtg gctcgcaaga aggacttttg 2767501 cgccttggtc tgcaaggtgt ttgattgttg gaagcgcagc acggatacgt gtatcgtctg 2767561 ttacttcccc gtctttcatt ggaacgttaa agtcaacgcg gcagaataca actttgcctt 2767621 ttacgtcgat gtctttgaga gtttttttat tcatgcctag gagatcctcc ttcaaaatgg 2767681 tttgcataca gcacgaaaaa cgtgaaaccg tctgttcaag cgataactcc gctagggcag 2767741 atcgcagtct ttttcggcac agggcagttc gtctaaaagc cagggcagcg gccttaggcg 2767801 aaagcgccgg caaagctgct taaaacgcgg tcgtttctct atcacagagc gttttctgaa 2767861 agccggtctt catggaaaaa gggaaaggga gtccgtcccc ttcccttgtc cgctttcatt 2767921 atagcgcttc tattcgaaag aaccaagtca ggtccttttt cagctataaa ttaaagacct 2767981 ttttttgcga tgtaagctgc aaggtcaaca acgcggttag agtagccgct ttcgttatcg 2768041 taccaagaga ttacttttac catgctgcct tccataacca ttgtagaaag agcatcgatt 2768101 gtagaagagt ttttgtttcc gttgtagtcg ccagaaacta atggctcttc gctgtagcca 2768161 aggattcctt taaggtcgcc ttcagccgct tctttaagag ctgcgtttac ttcttcagct 2768221 gttacttctt ggttcagttc agcaaccaag tcaactagag aaacgtttgg agttggaaca 2768281 cgcattgctc caccgttcag tttgcctttt agttcaggaa gaactagaga aactgcttta 2768341 gcagcaccag ttgatgttgg gatgatgttt tcagctgctg cacgcgcacg acggtagtct 2768401 ttgtgcggaa gatcaaggat ttgctgatcg tttgtgtaag agtgaacagt tgtcatcata 2768461 ccgcgtttga tgccgaattt atcgttaagt acttttgcaa acggcgcaag gcagtttgtt 2768521 gtgcaagatg cgttagagat aacatcgtgg ttagccgcat cgtatttatc ttcgttaaca 2768581 cccataacga ttgtgatatc ttcttcgtta gcaggagcag agatgattac ttttttcgcg 2768641 ccagcttcta agtgtttcgc agcgtctgcg cgttttgtga agaaaccagt agattcaact 2768701 acgatttcaa cgccttgttt gccccagcta agtttagcag gatcgcgttc tgcagaaact 2768761 tcaattgttt tgccgttaac aacaaggttg ttaccgtcaa ctgaaacttc agcgtctaat 2768821 tttccgtgta cagaatcata ttgtaaaagg tgagccagca tgttagcatc tgttaaatcg 2768881 ttaaccgcta ctacctcaac ttcaggattg tttaatgctg cgcggaatac gttacgtcca 2768941 atacgaccaa aaccgttaat accgactttt actgccatga ttgtttcctc ctttaaataa 2769001 gtgagagata tttatattga gggattattc atcccttaat aacttctttg cggctccttc 2769061 gtctgtgacg agaaccgtgt tgcgtggctt tttaaagtaa gcctcgatcg cttcggcttt 2769121 tgatgatccg cccgctaccg caataatatc ggggatggcg tctatgtcat ccagctgcat 2769181 tccgacagaa tgcactttgt gaaccacttc gccgtccgcg ttaaaatagt agccgaacgc 2769241 ttccgtcacc gcgtcgttat catctatttt ctttaaatct tctaaaggcg tgtttctgcg 2769301 ctgagccata gttttagctt cgccgattcc gtgaaccagc atactcgctg atttaatggt 2769361 gttcagcacc tctttgacag aaggctcttc aataatagat gaataggcgc cttgtgacag 2769421 ctgtcccgga acaaacaaaa gccggtaagt gcctgaagcc ttctccgcca tatgcgcgca 2769481 tatggtgttc gcctggtttt tcacgtcttc gcctaaaccg cctcttgcag gcacaaacaa 2769541 aagctcgcgg tttttagaat ccggcgtcat catttcggcg acagcttcaa ttgtcgtacc 2769601 gccagttaca gcgacgatat ttttgcctga aaatcttttt ttcatacatg cgacagccgc 2769661 tcttcccatt tcttttttga cccatgggga ttgatcgctg tctccggata cgataatggc 2769721 atcctttaga tttaaacgtt cttttaatgt cttttccaaa agagtcaaac ctaaaacatc 2769781 tttcatcgta tcttccaaaa cagaaagcag ttcatagccc tcttctgtca atgtcatgcc 2769841 gtttgtctta atatcgacca ggttctgttc ctttaaaaac tgaacctcgc ccctcagcac 2769901 acgctcgctg attccgagac tggcagacag gcttcttcgc ccgatgggtt ctgtcagcct 2769961 gatatactgc aagatttcaa acctcttttg cataacgagc agaagatcag gcaataattt 2770021 tttttgagct tgtattaact ggttcatgac tcaaacgttc cttccttttt tgctggacat 2770081 tatatgtccc gctatgacaa aaaacgtccc gtcatagcca aaaaaaatca tttctgcttt 2770141 ctttaattat tttaacaggg tggaattgtt tattcaactg ttaagagcca attcatcgac 2770201 aatattcgca gagttttcat gccgcgtcgt tttatccagc aatattttat cctatatatc 2770261 tttatcttat acagaaagcg ccaaatggtg catcccaata taaacagccc ttcccgtaga 2770321 aagggctgtt tcattaaagc gttttcattt tatccaaagc ttttcaattt cctcgagcga 2770381 tttgttcttc gtttctggac agatcgtaac gacaaacagg aaacaaagga tgttaatcac 2770441 cgcaaagatc caaaatgtat aggcgagccc gaaagaatcg atcatcattg gcacaaactg 2770501 tccgatcgcc cagtttgctc cccataaaaa gatggtcgca atgcccgcgg cccgcgcacg 2770561 cagatggttc gggaagattt cagaaatcat aatccatgtg atcggtccga ccgagacaca 2770621 gaaagcagcg acaaaaccta atataaggac gatcatcatg atcccgcttg ttaactcaaa 2770681 ataaaacgac gtcccgatta aaatcataaa aatagccata aaagcagaac cgatggacat 2770741 cagttttttt cgtccgactt tatcaatcag caacaccgca ataacggtaa aaataacttc 2770801 tacaaccccg acgatacaag tcgtcacaaa tccggcgttt tgcccgaatc ccatcatttt 2770861 aaagatttcc ggcccgtagt aagtaatcgc gttcatgccg atgacttggt taaacagcgc 2770921 cagcaggatt ccaatgacaa gcgcctttct gagacccggc ttaaacagct gggagagcga 2770981 ccccatttgt tctattttta aagagttctc aatgttcttt aattcttctt ttgcaacagt 2771041 ttctccatta atacgtgtca ggatctttaa agcttcattt gttttgcccg ctttcgccag 2771101 ccatctcgga ctttccggga cgacgagcag gacaaggaaa aaaatgacgg atggcaccat 2771161 tccataagca agcatccatc tccagccggt gtgcacgccc cattcgtatg ttccggaccg 2771221 ctgcacagct agattaataa agtatgttgc ggaaataccc agtatcgtaa agagctgata 2771281 taacgaagat aaacttccgc gtatagcggg cggtgccgct tctgtaatat acgtaacaga 2771341 gagcgatgag cccatcccga ttcccagccc cccgataatc cttgcaatga ttaaggtgga 2771401 cacgtcttga gaaagcgctg aaacgattgc tgatatcgca aataacaaag cggctgtcat 2771461 taaaattttt ctccggccga atctgtcact taaaaatccg gatatcccga cgcccacaac 2771521 tcctccaatc ataatgcttg aaatgacaag tccctccata aacggactca ggctgtataa 2771581 atctttcaga aaaccgatgg cgccagaaat cactgccgtg tcatagccat acaataagcc 2771641 gccaagcccc gccgcacatg agatcaaaat gacaaatccc attgaatggc ttcttgttac 2771701 aggaacattt ggttctaatt gagttggagt attcttcatt tccctgccct cccgaatgtt 2771761 gagtaaagcg ttttcattta aaccttcaat tgtacgtact tatattaaaa tttaacgaaa 2771821 attacattta attagtacgt acaaatatag aataatcttg tttgcatttt ctgtcaatgt 2771881 tttcttacaa agaacgctgt gatatactga aatttgtccg tatacatttt ggaggaatgg 2771941 atatgttacc aaaatacgcg caagtaaaag aagaaatcag ttcttggatt aatcaaggca 2772001 aaatactgcc cgatcaaaaa atccctaccg aaaacgaatt aatgcagcaa ttcggcgtca 2772061 gccggcatac catccgcaaa gcgatcggag acctcgtatc acaaggtctg ctgtacagcg 2772121 tgcaaggcgg aggcaccttt gtcgcttcac gctctgctaa gtcagcgctg cattccaata 2772181 aaacgatcgg tgttttgaca acttacatat cagactatat tttcccgagc atcatcagag 2772241 gaatcgagtc ctatttaagc gagcaggggt attctatgct tttgacaagc acaaacaaca 2772301 acccggacaa tgaaagaaga ggcttagaaa acctgctgtc ccagcatatt gacggactca 2772361 tcgtagaacc gacaaaaagc gcccttcaaa ccccaaacat cggctattat ctgaacttgg 2772421 agaaaaacgg cattcctttt gcgatgatta acgcgtcata tgccgagctt gccgcgccaa 2772481 gttttacctt ggatgatgtg aaaggcggga tgatggcggc ggagcatttg ctttctctcg 2772541 gccacacgca tatgatgggt atttttaaag ctgatgacac acaaggcgtg aaacggatga 2772601 acggatttat acaggcgcac cgggagcgtg agttgtttcc ttctccggat atgatcgtga 2772661 catttacaac ggaagaaaaa gaatcaaaac ttctggagaa agtaaaagcc acactggaga 2772721 aaaacagcaa gcacatgccg acagccattc tttgttataa cgatgaaatt gcgctgaagg 2772781 tgattgatat gctgagggag atggatctta aagtgccgga ggatatgtct attgtcgggt 2772841 acgatgattc acatttcgcc caaatctcag aagtgaaact aacctctgtc aaacatccga 2772901 aatcagtgct tggaaaagca gccgccaaat atgtcattga ctgcttagag cataaaaagc 2772961 cgaagcaaga ggatgtcata tttgagcctg agttgatcat tcgccagtcc gcacgaaaac 2773021 tgaatgaata aaaaaagcaa tgtatgggtc tccccgctac attgcttttt ttatagctgt 2773081 tatctgtttt tccaaacgtc agcgatgatt tcaaacgaac gcattctgtc tgcgtgttca 2773141 aaggtttctg agttaaccat aatttcgtca gcctgtgtcg ttttgacgaa atcttcaagc 2773201 ttcgccttca cttcttccgg acctccgaca atcgtggagc tcagctgctc attgaccatc 2773261 gctttttcat acgggctcca gatttggtcc atatcctcaa caggcggttt aagctggtta 2773321 ggcgtaccgc ggacaagatc aagaaacctt tgataatggg aagtcgcaag gtgctgcgct 2773381 ttctcgtttg tatctgccgc gataatggtg acaccgacca tcgcatacgg ttcgtcgagc 2773441 acgtctgacg gcgtgaagga attgcggtac agctccaaag cgggaaccgt attcgccggt 2773501 gagaaatggg ccgcgaacgc aaacggaaga ccaagttcgc cagccagacg ggcgctgaag 2773561 ccgcttgagc ccagcagcca aatcggcaca tctatgccct ctccgggaat ggcgcgaact 2773621 tgattgcgca catttcctga cggtttaaaa taattgcgca gttcctctaa ttgttctgga 2773681 aaatcctccc cgctgttgat gtttctgcgg agcgctctgg ctgtcaattg gtctgttccc 2773741 ggcgcacgtc caagccccag atcaatccgc ccgggataca gtgtttccag tgtgccgaat 2773801 tgttcagcaa tgactaatga agagtggttg gggagcataa tgccgccgga accgacgcgg 2773861 attttcttcg tgcctccggc aatatggcca atcaaaactg cggtggcaga gcttgcaaca 2773921 ccttctatat tatgatgttc agcaagccag taacggtgat agccccattc ctctgcccgg 2773981 cgcgccaagt ccatgctgtt tcggaatgat tctgcaatcg ttcctccctg aacaaccgga 2774041 gataaattca agacagaaag caaggtatct ttgcgttggt tgttagacat attgttctcc 2774101 tttgcaaatg tgttatcagt aaacagccca aagctgtcag gtcatgattg aaagaacttc 2774161 tatcacacca taacacaact gcattcagga ataaaagaat ttgattcgat gaaattcgaa 2774221 caatataaaa cgaacggttt ggaacattat tctgctccaa acaactcctt agccatctca 2774281 ataaagagct tagccgccag agaagcctcc tttagcgacg gaacagcaag ctgcacatca 2774341 cggtatacct gcgggtccaa ttccctggtc accacatgct ctggcagcgg catccccgac 2774401 atggacattt ctgataaaat ggccaggccc aggccttctc tgatcatact gatcgaggtg 2774461 ttgatgttat agaccgtgaa agctgggtgc agcgtagcac ccgcctgcct gaacatatcg 2774521 ataaatggtg attcatagcc gccgtcacag acgatcatcg gttcatggtc aagatctttc 2774581 agcgtaatgg ctgaatgact ggcaagcggg tgatcgtccc tgagcacgac agccattttg 2774641 tcttttttca aatgaatgta ctccatctcc tctgttggat acagaagaat cccaacatct 2774701 atcatccgcg tatgaagcca ctccttgact tcatttacag ttccctcgtg cagcacgagc 2774761 tcaagtttcg gatatttttg tttaaattca ctgatcagct tcggcataaa ataagccgag 2774821 gcagttgaga atgtgccgat atggatcgtt cccagttcaa gccctttttc cgctgctgct 2774881 acctgctcaa ctttttcaat gccttttaag acttctctga tgtgtactaa gatctgtttt 2774941 cccgtatccg tcagcatcag gccattgcgg cggtcacgaa tgatcagctt tacatcaagc 2775001 tcagcttcga tcgcagaaat cgcatggctg acagccggct gtgtcatgtt cagcgcctga 2775061 cccgcttttg taaagcttcc cgtttcagct attttcacaa aaacctttaa ttgagtaatg 2775121 gtcataacaa tttacttatg ctccttataa aaaagattca ttttatttat cttatgttct 2775181 accgtatcat atgatggaaa agttctacaa ggagtgaatg aacaatgaag cagctcccaa 2775241 aaacgcggac agctctcctg ctcgcatttc tcgtcatcat gtggggcgtc aattggccgc 2775301 tgtccaaagc cgcgctcgcc tattctccgc cattattgtt cgcgggcatc cgaacgctga 2775361 tcggcgggct tttattagtc atagtcgcac tgccgcgtat tcataaatta cgcttaaaag 2775421 aaacgtggcc gatttatctt gtttctgctc ttttaaatat tacattattc tacggcctgc 2775481 aaacgatcgg gctgaattat cttccggccg gcctgttttc tgcaatcgtc ttcttccagc 2775541 ctgttctgat gggtgtattt tcttggctgt ggctcggcga atccatgttt gtaatgaaag 2775601 tgattggcct catcctcggt tttgcgggag tagccgtcat tagtgctgcg ggctttggcg 2775661 ggcatatttc tgtcattggg gttctgctgg ctctcggctc cgcagtcagc tgggcgctcg 2775721 ggacagtata tatgaaaaaa acaggcagcc gcgtcgattc catctggatg gtcgctctgc 2775781 agctgacgat cggaagcgtg tttctgctta tctccggctt ttggacagaa agcttttcgg 2775841 cgatccaatg gacagctccg tttattacga gcctgctgtt catctccgta ttcgttatcg 2775901 cactcggctg gcttgtcttt tttacgcttg tcggttcagg agaagcaagc aaggtcgcat 2775961 cttatacttt tttgattccg ctcatatcaa tcgtggccag ctccattttc ctgcatgaac 2776021 cgctcaccct tagcctcttg gcagggctgc tgctgattgt cacgagcatc tgtctcgtga 2776081 atacaaaatc aaaagcgcag aaagctgcgg cgattggtat aaacgagaaa gctgcacaat 2776141 aataaaaacc ctcttgccgg atgcggcaag agggtttctt atttactgat gcttgcgtcc 2776201 tttgaccaaa tatgcaactg taatcaaaag gtagatcgcc gcagtaatgc cggtaatgac 2776261 aattgatgtt gtcatgatga ccccgatcag aatggcgagt aatgccacaa tcgcaaacca 2776321 tgtcgtgtac gggaaccatt ttacataata ggccggtgtt tccgtttgct gttttctcga 2776381 ttttaaatga gcgaatccga tgatcagcca aatgaataaa acggtatatc ccaatgatcc 2776441 cattaaataa ttaaatgttt ggcttcctgc gaacagagaa atcaatacgc caatatagag 2776501 agaagaagtg cacatcagaa tcgcaaacat cggtacgttt ttcgatgaaa gcttcgagaa 2776561 gacctttgga agccttccgt cacttgcctg tgtatacaaa atgcgtgatg atccgtataa 2776621 acctgaattc atagaagaaa tgatcgccag caggatgact gcattcatga tatgatccgc 2776681 gcccggaatg cctaccattt taaagaccat cacgaaagga ctttccggaa cggaattgac 2776741 ttggttccat ggaatcaggc tgacgatgat gaaaaacggc agcaggtaaa acgcgacaat 2776801 ccgtgtcagt gtgctgcgga cagctttcgg gacaaccttt tccggatttt ttgtctctgc 2776861 aagcgttaca ccgataattt ctgtaccgcc gtaagagtag atgacgacaa gcatcgccgt 2776921 gatcagccct gtgccgccgt gcgggaaaaa tccgccgtgg tctgtcaggt tggaaaatcc 2776981 ggatgctgta tgatcaccga atgatacaaa taagagcagc aatcccagaa taataaagat 2777041 aataataacg gtaatcttga tcattgccag ccaatattca gtttcggcga agattttaac 2777101 agaaagcaag tttacaatcg tgacgataag agaaattcct aatgccaaca cccagatcgg 2777161 gcagcccggc agccaatatt gaatgaaaat cgcagctaca acagcttcag ccgcaatgtt 2777221 aagcacccac attttccagt agatccagtc caaaaagtaa gcagcgtaat ttcccaatac 2777281 ctgctggaca agatcacgga aggttctggc gttacggttt cgaacagcca tttccgccag 2777341 cccctgcata ataaacagca aaataatccc gccgagcagg tatgcgataa tgacagatgg 2777401 ccctgccaca tcgatcgctg agctgctccc cttaaataaa cctgcgccga ttgctccgcc 2777461 cagcgccatc atcataatat ggcgggacgt catcgtgcgt tttaacgttt gattgtcgtt 2777521 tttcatcctc ttctacctct ccttctcgtt ttcaaaaaca aaaaagcccg ccgtctccta 2777581 cctaatctaa tagataaaga gacgacgagc cttcggctga ccgcggtacc actcttgttg 2777641 attcttcatg aagaatcctg cttttgacct gtaacgaagg ttagccgtta aaacataggg 2777701 aatattcaat ctattccgtt ccgtcttacc actcccgggc gagttcaaag aagaatcagg 2777761 ctgcgtcgca ccaccccgca gctctctgtt ctgatcactt tcttttactg ctcccaatct 2777821 atgtgtttta gttttctgaa aaactcaaat tttatgatct gaatatatta acataatata 2777881 cgtgcttctc ttttaactgt caataacttc agagaaaaaa gaaactgtta ttttgtccct 2777941 tttcgaatgg ctttccaaaa ggattctgac tcgtttccta atgcgtaaac tgaaacacct 2778001 gctattttat attgctttgc cagatggctt ttcgtttgaa cggttttttc gttttcatac 2778061 cacacgacat gtttatgctt ctttttgtca acataagaaa acgtcatcga gcctgatttt 2778121 ttgttgaatg ccggctttgc tttttgtttt ttgatgaggg atttgagctc attccattcc 2778181 cttattgtgc tggtacttcc gtcttttaca tcccagtcat agccgtacgc agggattccc 2778241 atgatgactt tattggcttt gatctttttg actgaaaact gcagagagct tttgatccag 2778301 tttgtgcttg ccactgaccc cggctcaccc caaatgccgt gttcatcgta ggtcatgact 2778361 tgtacgaagt cggcatattt gccgattttc gcataatcat acggccagct ccagtcatca 2778421 tttttatcat cggcgctttt ggccggaacg gataccattg ttttaatatg tttcttattc 2778481 aaagcctgtg agacatattg aatgaagttc gagtatgcag cgcggtcttc tggatttact 2778541 gcttcaaaat cgatattgat tccgtaatat gagtgctttt tggccagtgt aattaactga 2778601 tctgtgaatc gttttttcgc tgttttattg ctcatgaccc gactcgctaa atctccgtca 2778661 aaatcataaa tggcatcatt atagtttgaa atgacagccc atgtcttgat ttttttcttt 2778721 ttcgcatatg tcagctgctt agttggggca tcgccaatga tttgtccgtt tttttcaaac 2778781 gcaaatgtat cggttgcgat ggcattcatg tatgtatgat atttcgtaag agaattgtat 2778841 gaagccgtat ccccagtcgt gtagcctact gtcataccgg ctgccttcgc ttctcctttt 2778901 gtatacataa acagaacaat cgcaatcgcc agtgaaaccg ctatgatcag ccattttttc 2778961 atcgcatttc ctcctgtatc aagtcatact cttctcatcg gccaaaaaat tggaagttga 2779021 agttttttca agcaaaaagc ccggcatatg cctgccgggc ttcctgagtt cagcggtcag 2779081 agacgagaat atatgctgcc tttactggtc catgcacccc cacaactaaa tccatttcaa 2779141 tgtcggctga gttactcggt ccggtaatgt agttgataca tgaaggaaca gtgacaccgt 2779201 tcgcaatgtt ttggcggatg atatcactgg cttgtgtcat tctcggtaca atgcttgatt 2779261 tcggcacgat cgcaatataa gtcgttggca aaaggctgac agagcggccg atgtcttttg 2779321 aggagaagag gacaaccgtc cccgactcag ccaatgtaat ttcgctgaat gtaatcccta 2779381 cattggcttg ctccgctttt ttaatatttt cctcgccttt gtcagcatcc cactcccaga 2779441 ccggcgttcc ttcactcggc cagtccttgg tgagcaggct tttcagtccg tattcttcaa 2779501 agcgggggtc cttcggaatg atgacagggc ctccagaaaa gcggctgact tgctcgcgca 2779561 gggcatcgta aaggccggtt gaatccgttt caatcagctc tgtatggatt ttgacacaat 2779621 ggtttttgag cactgtgact aagtcatccg ctgaataacc ttcaagtgtt ttatattgcg 2779681 gctgatgcgc ccattcaggg actgccacgc ctcctgttct tcgttcacgg cccaggctgg 2779741 atgcgattcg gtttaaaaag ctctcttgat tctgaatggt tcccttcgtc atcactgctc 2779801 ctccttcgtg cgttcacttg tttctctgtc cgcaaaccag tctctgaatc tcgatttatg 2779861 cggtgccggg aagtcgcgaa tctgggtcca atttttaagc gggccgggcc ctttcgaaat 2779921 tttttcgtcc tctgtaaaag gcgtcatggc ggccggcgcc cattttgagc ccattttgta 2779981 aagcgataag gaggatgcgc caagtccgaa tgctttcatt gcaagctttt cactgatcgg 2780041 cgccctgcct tctttttcga cgatattctg acgatgcttg agtagcagct catgaagcgg 2780101 gattttgacc gggcaggctt ctgaacaagc agcgcacagt gaagatgcgt acggcagctc 2780161 cttataatcg tcataaccgc cgagcaacgg tgataaaaca gctccgatcg gccccgagta 2780221 gattgagccg tatgaatgtc cgccgacatg gcggtacaca ggacagacat tgatacaggc 2780281 ggcacagcgg atacattgca gcacagactg gaattccgtt ccaaggatat tggatcgtcc 2780341 attatcaacg atgacaagat ggaattcttc cggaccgtcc acttcacctt ccagcttcgg 2780401 acccgtcaaa gctgtaatat agcttgtcag ccgctgtccg acagcacttc tagtcagcat 2780461 gctgactagc acttcaaatt cagaaaatga cgggacaatc cgctccattc ccatgacggt 2780521 aatttgtgtt ttcggcaagg tgctcacaag ccgtccattt ccttcattgg tcacaaggct 2780581 gacggaaccc gtgtcagcga tggcgaagtt acagccggta atgccgatat ccgcttccag 2780641 aaactttttc cggagaatgg cgcgcgcatg catcaccagc tcttccggtt tttctgtatg 2780701 ttgatagtcc agtctttctt taaacacatc gcgtatctgc tctttatttt tatgaagagc 2780761 gggcgctacg atatgtgacg gcggatcgtg atcatcaatc tgcaaaatat actcgccgag 2780821 atcggtttct acgacttcac agccttcctt ctccagcacc tcattcagat tgatttcctc 2780881 tgtgaccatt gatttagatt tcacaatttt cttcccgttc ttcttttgaa tgacatcccg 2780941 aatataggaa gacgcctctt ccgctgtttt cgcgaaatag acatgtccgc ctcttttcgc 2781001 cacattttcg gcaagctgtc cgagatagaa atcaaggttt tcaaggacat gctgcctgat 2781061 ttcctctgat aatgagcgcc actcctccca gtttcccagt tcttctgctg cctctaggcg 2781121 ccgcgtccgc agacgctcct gtgcacctga aacagcgcct ctcataaatt cattatcaat 2781181 cccctgtgat acccgctctt taaaagcgtc agtaccgatt ttcatcgcca tgatcctttc 2781241 cccctctgaa tccagtttta tctgctgttg agcacttcgg cgatgtgcat cactttgaca 2781301 ttcttatctt ttcggccaag ccgtcccccg atattcatca aacagccgca gtcagcaccg 2781361 atcagcacct ctgctcccgt ttcctccaca cattcgactt tttcatcgac catctgctca 2781421 gaaatctgcg ccatcttgac tgagaacgtt cctccgaatc cgcagcagtt atgtttgccc 2781481 ggaagctctg taaactgcag gcccttcaca tggctcaaca gcttcatcgg ctccttccga 2781541 acacccagca gcctagtcat atggcacgac gtatgtaagg tcgcttttgt atgaagggtc 2781601 gcgccgacat cctctacccc aaggacgttc acaataaaat ctgtcagttc atacgtttta 2781661 tccgccagct ttttcgcttt atcggcccat ttcggatcat cctgaaacag gtgcggatac 2781721 tcccggaaca tcgttgtgca ggaacccgaa ggactgacaa catattcgga atcctgaaac 2781781 gtttcgatca tccgtttcat tgcttttttg gcgtcatgta catagccgct gttgtaagcc 2781841 ggctgtccgc agcaaatctg cccttctgga aaatcaacct cgcacccaag ccgctccagc 2781901 agctcaaccg ttgcttttcc gacatttgtt tgaaacatat caacaagaca agtgacaaaa 2781961 agtgagactt tcatgatgaa cccctctctc atccccaata tatgatcagg tcatctgatg 2782021 acctgagtta aaataactat atgaatatcg tacactattc tgacaatgga aggaaagagt 2782081 tttctaggga tattttcatt tgtggcatat caaaaacact cccgatctcc caggagtgca 2782141 gtatatggtt agatccagcc cttttcctca gcgatgctgg cggcttctgt ccgatttttc 2782201 gcattaagct tttggatgat ttctgagata tagtttcgaa ctgtgccttg agataaatag 2782261 agctccagcg taatgtcttt tgttgtcttg cctaaagccg caagcctcag aatttcttgc 2782321 tctctaacgg ttagcggatt ttcgtctcgc atcatattaa acgtcagctc agggctgaag 2782381 acacgttttc cctttacaca ttttcgaatg gcatcggcca gatcgtcaat ttcaccgtct 2782441 ttcagcagat agccatgtgc accggccttt acggcgcgtt caaaatatcc ggggcgggca 2782501 aaggtggtta aaataatgac cttgctgacg cagccttttt tcattaattc ctctgccaca 2782561 ttcagcccgc ttcgaaccgg catttcaatg tccataatgc atacatccgg ctccagcttc 2782621 aaaatagcat gtagcgcctc ttccccgttt aatgcttgtc cgatgactgt catatcctct 2782681 tctaaatcaa gcaaagatcc caaagcgcct aaaagcattc gctggtcctc agcaataaac 2782741 agacgaatca ttcttttcgt cctccaatca ttctgctttt ttaataagcg gaatcgtcag 2782801 tgccacaacc gttccgttat ggtctgaaac cgttaatccc ccttcaatga gcatgagccg 2782861 ttcttccatt ccccacaggc cattcccaaa cattttctcc ttcggcgctc cctttccgtc 2782921 atcccgtatt acgatcctca ttttgtcagc aaattgagaa atggtgatgg cacagtgggt 2782981 tgctttgctg tgcttgataa tgttagtcac ggcttcccgc atacacatac tgataatatt 2783041 ttgagtgacg ggagatatca ctgaaaagtc gtcggctcct tcgtattgaa aggtaatgtt 2783101 ccccgctctt aatatgtgct gaatgtttac gagctcctct gttatcgtga ccgttctcat 2783161 atcagaaacc agctctcgaa cttgcttgag tgcggagcgt gaactggttt ccatttcttt 2783221 tgcctcaagc ttggtccgtt ctggatcaga tgcagccagc cgctgaatga gctggctttt 2783281 taatgtaagc agcgacaggg tgtggccaag agtatcgtga agatcacggg cgattcgaac 2783341 acgttcctcc cttttagaga gttcttttat ctgttcgttg gcttgtgcaa gcttagcttc 2783401 aagctcaatc ctccgaaaca tagaacgaat tccgaatgga gaaatgagca taatgacgag 2783461 aaacgggaga acagaaaaaa gctcccgaag cgagaccgaa ttcgcgataa attggtatag 2783521 gcatggaaaa agcagtataa agattaaagc gcagaacgca cggttaaaat tcgttttctc 2783581 tttgtaataa ccaacaaagt ttgccggaaa aaaacctaag tatatatagg tgatattgta 2783641 aaacacacta tacatcaaaa taaccgccat ttgcacgata agccaatatg taaacgaagc 2783701 tttgcccacg ctgcagaata actggcgata tgccgctaca aaaaggagca gcataccata 2783761 tccgatcccc tgtttgaccc ctgattcttt taataaagag aggaacggca taatcgtata 2783821 caccagaaag atataaggga aaaacccgaa ttccttcggg aaaatagata ttgccttttt 2783881 catgtattac accgcttctt gttttcttct tatatattta gatagtagca tgaagagcat 2783941 catataagcg attaatatca gaatattttt ccaagtcgga ctcccacccc ggacaagttc 2784001 ccacgctccg ctcccgaaat gataagacgg aagccactgg ccaatgctct gcatcatgtc 2784061 aggcatgacc tcaaacggca tccacatccc tccgcctaaa gccagcagca tataaagcac 2784121 attactgatt ccggccgctg tttctacttt tctcatgagg ccgattagtg tgcctaatgc 2784181 taaaaaaggc aatgcgccaa acaaaatcca cagtccgctc atcatccatt caaacggtga 2784241 caaggcaata tcattgatga ttgcgccgaa cagaaatatg acggtaattg ataaaacgtg 2784301 aatgacactt tggccgatca tctgagctga taaatagata tgatccggaa gaggcgtaag 2784361 gcggataaag gcggcccagc cttgtgaccg ttcttgtacc attcggatgc caagcgtcat 2784421 gatagaggaa cccatcacgc tgaagactgt catcgacatc aggtaatggg cttcccatgc 2784481 acgttgatca gggacgttgg tattcactac atttgtaaag aaataataaa aggcaatcgg 2784541 catgatcaga gaccaaagca caaagtactt gttcctaagc acccttttca tttcagcgat 2784601 gctttgcttt tgcagcacgt tcactcacat cgcctccctg ttgccgtcag ccagctggcg 2784661 aaatgcctca tcgagcgttg cttgctcaat tcgaatatcc cgtgcatgta tgttttcttg 2784721 aaagatcagc gccaacactt tgtctgtatt tgatgtctgg atgatggttc tctcatgctc 2784781 gtggatcact ctctcgactt ccgggtgaca agacagcctt tccaatgatt cacttgaatg 2784841 aagcgtaaag gaaacagact gtttttgaat tcttgagcgg atttgcattg gtgagccgtc 2784901 tgcaacaagc tgtccttcag taaaaaatag gattcgctgt gcggcatcat ctgcttcctg 2784961 taaataatga gttgaaaaaa taatcgtttt tccttggtcc gacagtccgt gaatggtctg 2785021 ccagaatcgg tgtcttgatg aagtgtccat gccgactgtc ggttcatcaa gtataagcag 2785081 ctccgggttc ccggcaagag ccaaagcaaa gctcaaacgg cgtttttgtc cgccggataa 2785141 tttttctgct cttgttttca aatcttcttt ggtgagtgct gttaacgaaa cgagttcttt 2785201 catggacaat ggattcggat aatagctccg gaagagttca aggatttcat ccaccttaag 2785261 gcccggcatg acacttactt cctgaagcat tacacctatt ttttcacgaa cctgttgatc 2785321 atcgggaacc cggttaaata gtttgatttc tccctcactc ggtttcagca atcctaatat 2785381 catcgagacg acggtcgtct tccctgcccc atttggcccg agaatggctg caatttctcc 2785441 tttttcaata ctgaagctga tgttgtttac agcggttttt cgctggaaat gttttgtcac 2785501 gttgcttact gttactgctt ctttcatcac atgagcacct cctgatcgtt tacattgatt 2785561 gtaaaatgac ggagaagacg atgttagtat ggggtgtcat gatgatggag tgacaaatgt 2785621 catttttttc tcaccccggt gtctaggcaa tcctcctcct gcatcttcca attcatccat 2785681 cttttctatc tcccatgtcc tctttctttt aaactgctgt gacattcata gaaagataca 2785741 ctcttcaaac catccgagtg ttatgataga aatattgaac tttatattac tttccggctg 2785801 aaaggagcca atcatgaacg aagcgatttt gtctagaaat catgtgaagg tgaaaggcag 2785861 cggcaaagca tctatcatgt tcgcacctgg ttttggatgc gatcaaagcg tgtggaatgc 2785921 cgtggcacct gcctttgaag aagatcatcg ggtgatttta tttgattacg tcggttcggg 2785981 acattcagat ttgcgcgcat atgacctgaa tcgttaccag acacttgacg gctatgccca 2786041 ggatgttctt gatgtttgtg aagctttaga tctgaaggaa accgtgtttg tgggtcactc 2786101 cgtcggggcc ttgattggga tgcttgcatc catccgccgc ccggagcttt tttcccatct 2786161 ggtgatggtg gggccttctc cttgctattt gaatgatccg cctgagtatt acggaggatt 2786221 tgaagaggag cagctccttg gcttgctgga gatgatggag aaaaattata tcggctgggc 2786281 gactgtattt gcggcaaccg ttctgaatca gccagatcgg cctgaaatta aggaagagct 2786341 tgaaagccgt ttttgttcta ctgatcctgt cattgcccgc caattcgcga aagcggcgtt 2786401 tttttctgat caccgagagg atctttcgaa ggtaacggtt ccctctctta ttctccaatg 2786461 tgcagatgat atcatcgcac ctgcaacagt aggtaagtat atgcatcagc atctgcctta 2786521 tagcagtctg aaacaaatgg aggctcgcgg acattgccct catatgagcc atccagatga 2786581 gacgatacag ctgatcggcg attatttaaa agcacacgtg tgatatagga acgaaaggga 2786641 tagaggtgac cctcttagat ggacaaacaa ttgaatgatg caccatgcgg tttcctcgct 2786701 ttgtcagaag aggggtcgat catagctgcc aaccgcaccc ttatcaagat tctggattat 2786761 gaaccggagc aggttatcgg ccagcacatg aatatgatgt tgaccattcc cgcgcagctt 2786821 ttctgccagc tttatttttt tccgcttttg aaattggagc atcacatcga agaaatatac 2786881 atttccctga aagcaagaga tggagaagaa attcccgtcc ttatcaatgc tattgcgaga 2786941 cacgatagcg gggcttctgt ctttgattgt gttctgattc caatgcgaaa gcgaaatgaa 2787001 tatgaaaatg agctgctgat agccagaaat gaggctcagg aagctttgct tgccaaacag 2787061 aaagccaatg cggagttaga aattgccttg gaaacgctga aagcaaaaca agaagaactt 2787121 cttgagatca ataaacaaaa tcaacaattt aaattaaaca ccaaaagaga gcttgaactc 2787181 gccagaaaga tccagaaaaa ctcgttgact gaaccgattg taaacgatca ggttcagatt 2787241 gactcttatt acaacgcatc gagtgaattg tcaggtgatc tttacggata ttatcaaatc 2787301 gatgaacacc gttacggcat tattatcctt gatgtgatgg ggcacggaat ttcatctgca 2787361 ttgattacga tgtctcttca tcctttgttc cagcgccaga tcacgcaagg tctcagcccc 2787421 gttaaagtta tgaaggaatt ggaccggcac cttcacagct tgtttcaaaa tgatgaggaa 2787481 gcaagacatt attgcactgc tatttatctc gagattgata tagcacggca aagaattgat 2787541 tatgtcaacg cagggcatcc gccggcactt tggcaggacg atagcggaac tcaacatctg 2787601 cttcacgcga cctcgcctcc gatcgggatg tttgaagact tagagtttca gtcaagcagc 2787661 ctttcataca cggaggacgg aagattgctt ctgtatacgg atggcgtgat ggatcctacg 2787721 gcttcatgtt atttatttga tttactaaag gatcatcctg attcgccaat cgctgacctg 2787781 aaggagaaaa tccttacatc actgcagcat caaaaggaag ctcatcataa gagtgatgac 2787841 gaatgtttta tattagttga tgtaaaataa aatgatccat gagacataac aatgatttgt 2787901 tacatctcat ggattttttt gtttcagcgt ttctttggaa tatgtcctga ctccgcatat 2787961 tgaaacacct gcaaggaagg cagcgggtgt ccattaaaat caaataaagc ttgattatct 2788021 acagcacttc ccccatacca cttcccggcg tcttcagggt cgtattcagc agcatagctg 2788081 gacgcccacc ctgacccgta tgtttcccat aacactttgt ttttctctat ctgtgtcttc 2788141 ggcccgactg gaatccacgc cggctcccag tagaaaacac caagtcctgc tttgcccgta 2788201 ttcgccactg cctccattac atctcttact gcagttgcct ggccttgaac agaaattgga 2788261 tatggcaacg tctgcccgct ttttggtgct gtatttccat gcccatcgcc atcctcagcg 2788321 gtataggtgt acgatgtctc cgccaccatg acttttttgc cgtacgtatt ggcaacagcc 2788381 ttcagcacgg aggtcaaatt ttgtaatgtg ccatgccaga aaggataata ggagctagca 2788441 aacacatcat aatccacttt gtttttgctg agtgtttctg caataaatga ataccttcca 2788501 gccgtttcag gattggtaaa atgcagggcg accaaaatat ttgaatttgt ctccctgacc 2788561 gctcggcttc cttcattaaa taattggcac atcttcgtcc aatcagtctc accggcaaat 2788621 cctcctgttg tttcatttcc gacctgaacc atgccgatgt caacgccttc cttgatcatc 2788681 ttttgcaggc tttgtttcgt atactcatag agctttgctt tttttgcttc aaagctgaga 2788741 ttcgcccagg ctttgggcac cttttgtttc gctggatcgg cccagaaatc agagtagtga 2788801 aagtcggcca gcaccttcat tccgttcgct gtcgctcttt ttccgatttc gatggctttt 2788861 tgaacatcat tgtttccccc gccatacccg ttgccatttg aatcatacgg gtgattccag 2788921 atgcggacgc gaacatagtt gaccccagcc tgttttaaag ttgtaaagat atcctggcgt 2788981 tttccgtttg tattgtaaaa ggtgacaccg ctgttttcca aagcaataac gctggataca 2789041 tctgcccctt tgataaaatc cttgttcatc ccctctactt ttttaacaaa aagatcctct 2789101 gcccgaagct ctgacacgtg cttctccttc tcaatggcag cggcatatcc tgttgaacta 2789161 catgcactcc acacgatggc agccgcaaag aacattttca ctttgctttt catgatttca 2789221 tccccccaag acttagcaag cgttttcatt ctatagaaaa aagaatccgc ccatatcgag 2789281 cggagcatca gcctaatgtg tgtttacgac aattctcact tcatactttt ccatcgtcag 2789341 gtcgcctgac aatatgtctc ctgtcattat gtccttcaca ctctgatcaa acgtgaccag 2789401 ctgtttttct tccgtgaaat tcatgacaaa aatataatca ttgtcctgat cctgcctcgc 2789461 ttgtacggag acgccttttc cgtgccgaac cggaaaaact ggagagagag acaggtctgt 2789521 gatcagaccc tcatagaaat cacgctgaaa ttgatcctcc aaacgcgcgc cgataaaata 2789581 cgccttgccc tgctgatact catggcttgt gaccgctggc gtgcgcgcat aaaaatcttc 2789641 ttgatacacc gcttccactg aagctgtctt tacatcaatc acggttgcat aatccttcat 2789701 ttcatatatt tggctgcggt agctgacagc gtttcgatcc ttcggataca gggtgtccgt 2789761 ttcaagaggc tcaactccaa atatagcttg aagatccgga tgccatccgc ctgtgtatgt 2789821 taagtcatgc tcattcacaa ccccgctgat atacgtcatg actaaggtgc cgccgtcagc 2789881 cgtaaacgct tttaaacggg aaacggtgtc ctcgctgatt aaatacagca tcgggacgat 2789941 cagcagttta tatggtgaaa agtcttgttc tttcgtgatg acgtcgacag ggatatcgtg 2790001 ttcccagaat gtgcggtaat gctgctgaag cgtttgcgga taacgttttg tcgccttcgc 2790061 aaacccctga gcatcctcga gcgcccaatg attttcccag tcatataaaa tcgcggtttg 2790121 agccggcctc ttcgttccga caacttcgga cagccgttcc aatgtctcgc ctaccttggc 2790181 cacttcttga aagacgcggt tcttcgggct attgtcatga tccacaaccg ctccgtgtaa 2790241 tttttctgat gacccccgtg atttgcggta ttggaaatag agaacgctgt ccgagccgtg 2790301 ggcaatcatt tgcatggatg acagcagatt catgcccggg cgctttgcct tgttgacgtt 2790361 atgccaattg accgcgcttg gcgtacactc cattaataag aagggctgct gcttcaagct 2790421 tcggtacaga tcattgataa agccgacctt catcgccaaa tcagctgtgc tttcccagtc 2790481 attgtgccag acaggataag cgtcccagct gatggcatcg acatgctttg caaatttgct 2790541 gtagtcgagg ccctgatacg ggatcaaatc cggtgtgtca gccataaaat tcgttgtgat 2790601 agggatatca ggcgtcaatt ctttcagcgg aatgatttca ttttcataaa acgaaatcgt 2790661 ttgatcggtg acgaaccggc gccaatctaa attcaggcca tgcaagccat tttcaccgat 2790721 cggcgaaggg ctttcaattt gtgaccagtc attgaacgta tggctccaaa aaggggtcca 2790781 ccacgcatgg ttcaatgtct tgaggctgtt gtcatatttc gatttcagcc actcccggaa 2790841 agcatgctgg cataaatcac agtggcaatc tcccccgtat tcgtttgaaa tgtgccacat 2790901 taacagcgcc gggtgatgtc cgtatcgttc tgctaataag cggttgatgt gccgtgtttt 2790961 ttctcggtag actttagatg tgaggcagtg gttgtgcctt ccgccgtgca gctgtttgac 2791021 gcgggaggca ttgacgcgca aaacttccgg ataggtttgc gacagccagg ccggacgggc 2791081 tccgctcggc gttgctaata tgacccggcc gcctatactg tgaatccgct caaaaatatc 2791141 atccagccat tcaaattgat atacgccctc ctccggctca agtgcgctcc atgcaaaaat 2791201 gccgacagaa aacgtattcg tatgagaaag cttcatcagt ttgatatcgt cagctaaaat 2791261 atcgggccga tccagccact gatcggggtt gtagtctccc ccatggagca taaattttgc 2791321 ttttgttacg tgcgtttttt caagctttga catcacattc tcctccttgt tctcttagcc 2791381 cttcgttccg cctgcggtta atccggacac aaaattcttt tgcagcataa taaagatgac 2791441 ggcaaccggt atgctgataa gcagggctcc ggccgcaaat gtcgtatagc tggcccccat 2791501 gacatcattc actaaattga atagaccgac gggcaatgta tatgattcag gcgttctcaa 2791561 tatggttgag gacagcacaa aatctccgag cggaccggta aagccgttca tggccacgac 2791621 tgccgccatc ggttttgata atggcagaat gatctggaag aagattctgg tgctgctggc 2791681 tccgtcaatc ttggcgcttt cgtctaaatc catcggaatg gaatccatgt accctttcat 2791741 caaatacgta ttcatcggga tcaggccgcc gatataaagc aagattagca gccagtggct 2791801 attgatcatt cccaagattt gcgccagcac aaacaaggca attaaagctg aaaactgagg 2791861 aatcatctgc agcaataaaa agagcgttaa agcgtatttc ctccctttaa accgaaagcg 2791921 cgaaaacgca taggccgtaa acgtcacaca gagcaaagac cctgccattg taaacaggct 2791981 gatcttcata gagttgacat accactgcac atattgaagg ctttccttgc ccgcaaataa 2792041 ttccttgtaa tgatcgaatg tcggatgctt cggaatgatg gatgtactga ttaagctgtt 2792101 gccgggatta aagcttgcgc ctgccgtcca aaggagagga taaacaatga tgaccgccat 2792161 aaaggctagc aacaagtaag agaaaaggag acggatatat cttctgactt tcatatctgc 2792221 cagcatacct tatgcctcct ctttaaaaga ctttgtctgt ctgaactgcc acaatgcgat 2792281 ggagataaca aatacagata ataaaatggt taaagccgca gcaagtgaat attggctgga 2792341 ctgcattgtc aatttataaa tccatgaaac gaggatatct gtcccgccgg ctgttgatcc 2792401 ggttacagcc ggacctccgc cattgaatag atagataata ttaaagttat taaagttaaa 2792461 cgtaaactga gtaatgataa tcggagccat tgcaatgaac accatcggaa gcgtgatgta 2792521 tctcagcttt gaaaagacag aagcgccatc aatcgtagct gcttcataca gatcgtccgg 2792581 gatggattgc aatacgcctg ttgagacgag aaagatgtac ggaaatccga gccagccctg 2792641 catgagaatc aatgcaagcc tcgaccaatt ggcatctgtc atccacggaa gcggatctat 2792701 cccgaagaaa gccaagatgt cgtgattcat cgcaccgaag ctatcattaa acagtcccgc 2792761 aaaaattaaa atcgtcacaa aaccgggaac ggcccatggc aaaatcagaa tcgtccgaaa 2792821 aaaacgttta aaccgaaggt ctttctggtt aacaatgatc gcgagaaaaa tccccaaggt 2792881 gacttgcagt gtggatgcag caagtgtcca aaccaccgtc caagccagta catcaaaaaa 2792941 agtcgacctc caaatatcaa ctgtgaaaat atttgcgaac gtttgaaaac cgacccaatc 2793001 aattaatttt gcaggaggag aatgatacaa atcatagttt gtaaacgcta atgcaaagct 2793061 gaataagata ggaaagatca cggcgaaaat taaaataaac aaagatgggc cgctgacgac 2793121 ataaggatag ccctcagaaa tgatatgctg gtattgttcc tttaaggaac ttaatggctt 2793181 attttcatca cgctgttttc cgctttggaa cgcatcgcga agatttacat aatacaccgc 2793241 aaggccaaag caggtcacga tgacagcaat aatcccttcc gccagcagaa aaacggaatt 2793301 atcccgcggc acttctgttc ccagtgtaaa gattccccaa aaccccatat tgagcagatc 2793361 tccaaagacc gcaaaaaacg atgcgcctaa gaaaagaaag acaatacctt ttatccattg 2793421 cttgttataa aattgcccga gtcccggaat gatagaaagc aacaaagcga cttgacgatg 2793481 ctgcaccgtt ttcacctctc ttacaataca aatctagctt tctctttatt ttccgctgtg 2793541 ctttgcctta atttgtcctt tggccgtttc agctgcttga tccaatgctt gtttcggatc 2793601 tgccttccct gttgcaaccg tctgtaatgc tgaatcagcc ggcgtccata tttcattcat 2793661 ttccggaata tttggtgttg gctctgagaa acgggattgt tcagtaacag cccgtgccgc 2793721 ctcgcttttc ataatagccg ggtcattggc tagggatttc acagcaggaa cttctttcgt 2793781 ttcttcatat cgtgttttag aatttttttc atttgccagg aaaacggcta attcttgcgc 2793841 cagctcttca ttctttgaaa atgcactgac gttgtagctt ttgacgccga taaaggagct 2793901 catgtttttc ccattttcca gcttcggcag tttcgtaatg ccataattga ttcctgcatt 2793961 cgaaaaggct tctacattcc atggaccaga aataattgcg gcggcttttc cttctgtgaa 2794021 cagcgattcc aacacgttaa tcccttgttc tccaataatg ccagccggga acaggccatc 2794081 tttgtaaaac ttctgaatca gcgccgcacc tttgacagct ccttcattat tgattccaat 2794141 gtctgacggg ttatagctcc catctttggc ctttccaaaa atgtatccgc catatccgct 2794201 catcacactt tctgcataat aaatttgatc gaatagggct aaaaagccaa atttgctgcc 2794261 gtcagcagtc tttttggaat agtcgtacca ctcttccagc gttttgggca attccttttc 2794321 tgtgatgaga tctttgttgt aaaaaagcac agtcgtttcg accgcttttg gcagtccata 2794381 aagcttttga tctaccattt gagactgaat ggaagcgtca gtataaagtg attgaacgtc 2794441 ttttttgaca tgtaattcct tgagtaatcc ttccgtgaca gcggttccga tttggtcccc 2794501 tggcattgtt aacacgtcag ggcctgtgcc ggccggtcca tccattcgca aatcttcaat 2794561 ctgcttggca tacggttttt caacgacttt gaccttcaca tcatgctctt tttcaaatgc 2794621 agccacagcg tctttaatgc cgttgctctt ttctttatcc tcccatacaa caagctctga 2794681 cccttttgaa ctcgatttgg cgctgctgct ttcctttggg ccgcaagccg ccaaggataa 2794741 actgacagct gcgcagagca tgaatacgga acactttttt gccattttca ttgattgtca 2794801 ccctttcggt aggaatgaaa gcgctttaaa gataatatag catgcctgag aaaatgtgta 2794861 aacaaactat ttacttcata gagtaaattt ttttacctaa ataaaaaatg acttagtgtc 2794921 ctaagtcatc cttaattcat actcttcctg acgattaatt ctgcgcccac atataatgtt 2794981 tttaccgttc ttctcttgtc ctgcacttgt tcaagcagta attgaacagc gtttttacat 2795041 aattcatgta tatcaatatg aaacgtcgtc agaggaggcg agacatactt cgcgaagctg 2795101 atgttgttga tactcacaat gcttaccctg tttggtatgg caattccttt ttcgttcagg 2795161 gcttgcagac agcccactgc aatcgggtcc gctgcaatca taaaagcagt cggaagctga 2795221 tcgcctaatg tgtcgatcgc tgctgacatc aggcggtagc cgttttctac agagaatccg 2795281 cgatgacaga aaatatagcg ctcgtccagc atggcttttt ccctcatata ggatctgaag 2795341 gtttgttcac ggatgtccat ttcatcctga ttggtattcg gatttttgta tgtgccgccg 2795401 ataaaaccga tgctcttatg ccccttctca gtcaggatgt ttaccgtctt ccttgtcatt 2795461 tgtgccaaat cgggccttac cgagtcaaaa tgatcgggat caggagttga atcgatgaac 2795521 acgccgtttt cagtgagatt tctgaggaaa gccagctctt catctgaaaa tgtgccgacg 2795581 gcaataaacc cttccgtatg ttcaggaatg ctctcgattc catccgctat tttataagtg 2795641 gtcatatcga cattgaatgc tttcgccagt ttctctactt ctaatctcat cgttttaaaa 2795701 tagacatctt ctaattcttc tttatctgtc agccaatata aaaacgcaat atgtttcacc 2795761 agcggcctta ctgttttttt gcggtaattg agcttttccg ccgcttcata gattttctcc 2795821 cgtgtctcat caggaacaga aaggctttca tcgttattta aaacgcggga aacggttgag 2795881 attgaaaatc ccgcttcctg cgcgatatct ttaattgtcg ccattgtatc tgcctccatt 2795941 attcagctcg cattgtttta gtaaaatatt ttactttctt tttcacaaat gtcaagtgca 2796001 caaagccctc tggctgccat gtaaaaagac tgaaccattt gcggctcagt ctcagttgtt 2796061 cgtatcattc ggaaccggcg gaattgcccg ggaaatgagt tggttattgc acattttcct 2796121 cgaaatatcc cgaaagcaca tcttccacat tcgtcaaatg cgccagcatg gcggcttccg 2796181 cctgtgcacc gttcccggca gccacagcat tgtaaatccg ttcgtgctcc tcatacagcc 2796241 gctgaacgga ggtcttcttg gaaaacagcc agattttcct cgtttccctc attgtttcca 2796301 gcagcaatga tgacacgtga ttcatcaagt gtttaagaag ttcattttga gaagcgtccg 2796361 caagcgcaag atgaaatgca aagtctgctt tctctcccag ctccccgtcc gcttcaatgc 2796421 tgcccatttc ctttagtgca tcctgaattc tttcgagatc tgcttctgtc cttttttcag 2796481 ccgctagtga agccacgccg atttcaagca gttttctgac ctcgagcagc tgcttgacgt 2796541 cctctttttt catcagaagg gcggctgaga gcggctgaga aatttgattg agctcaaatt 2796601 ccttcagata cgtgccttct ccctgtttca tttcgacaag ccccatcgct tttagcgcag 2796661 aaagtgcttc gcgaaccgct gaacggctga cttgaaagct ctcagcaagc gcctgaacag 2796721 agtccagttt atcccccggc ttcaattcgc catttttgat catatctaat agggcatccg 2796781 ctacttcttc atatattttt ttgttttaat ctgtttatat ttcaatgcaa ttcaccccgt 2796841 aacttgtagg tctggctgtt tacgatctat tatactctgt tttgtgggcc gccaaaagat 2796901 tttgactatt ttgtcaaaaa gtcttgtact ttgatttttt tcaaaatata atgctaggta 2796961 actggtctta ttacccagtc atcagatgat catatcatct atagaaaccg cttacatatg 2797021 gcgccagttt atgtttcaag gaggggtttg ggatgcaatg gacacaggca tatacgccta 2797081 tagggggaaa tttgctatta tcagcgcttg ccgcacttgt accgattatt ttcttttttt 2797141 gggcactcgc gattaaacgg atgaaggggt atacagcagg cttggccaca ttggggatcg 2797201 cccttatcat tgctgtattg gtttatcgta tgccggcgga aaaagcgctg atgtccgcga 2797261 cacaaggagc cgtatacgga ttgttgccga tcggctggat cattgtgacg tctgtttttt 2797321 tgtataaaat cactgtgaaa acgggacagt ttgatatcat tcgcagctct gttctctcga 2797381 ttactgatga ccgacggctt caagctctct tgatcgcttt ttcattcggg gcttttttag 2797441 aaggggcagc aggcttcgga gcgccggtcg ccatttctgc cgcgctgctg gtcggtctcg 2797501 gctttaatcc tctttatgct gcggggatct gtttgatcgc caatacggcg ccggttgcct 2797561 ttggggcaat tgggattcca attacagccg tagaagggcc gacagggatt ccggcgatgg 2797621 agatttcgca aatggttggg cggcagctgc cgtttttatc cgtatttatt cctctttatt 2797681 taatcatcat catgagcggg ttcaggaaag ccttggagat ctggccggcg attctcgtat 2797741 ccggtgtttc ctttgctgtt gttcaatatc tcagttccaa ttttttaggg cctgagctgc 2797801 ccgatgtttt gtcagctctt gtttcaatgg ctgcgcttgc tgtgtttttg aaatggtgga 2797861 agccgaaaac aacattccgg tttgccggtg aacaagagtc ggccgcctca attgaaacgg 2797921 cgcgcacaaa tccggcggcg cctgcataca gaggcggaca gatttttaag gcttggtcgc 2797981 catttctgct gctgacggcg atgatttccg tatggggcat tccatctgtc aaatccgcgc 2798041 tgaccgggca ttatgaaggc tctgcggtgt tcttgaagtg gctgaatgct gttggagaaa 2798101 aactgacttt ttcccccggt gtgccttttt tgaacaatca gattgtcaat gctgacggta 2798161 cgccgattga agcggtttac aagttggagg tgcttggttc ggccggcacc gcgatattga 2798221 ttgccgcagt gctgtcaaaa ttcatcacgg cgatttcgtg gaaagactgg ggaaccgttt 2798281 ttaaagaaac agtccaggaa ttgaagcttc cgattttgac cattgcttct gtcgttggtt 2798341 ttgcctatgt caccaactcc tcgggaatga gcacgacact cgggatgaca ctcgcgctga 2798401 caggttcgat gtttaccttc ttttcgcccg ttctcggctg gctcggcgtc ttcattaccg 2798461 gctcggatac ttctgccaac ctgctgttcg gcaacctgca gaaagtcacc gcattatcag 2798521 tcggcatgga ccccgttctg tctgtggccg ccaactcttc aggcggtgtc acaggaaaaa 2798581 tgatttcacc gcagtcgata gcggtggcgt gcgccgcggt aggactcgcc ggaaaggagt 2798641 cagatctttt ccgctttacc attaaacaca gtctgttttt gctgctgctc gtctgtatca 2798701 tcaccttttt gcagcatcac gtattcagct ggatgattcc ttaaaaaaat cctcccgtct 2798761 agggaggatt ttatttatat cgctttctcg ctgccgatga cggaatattc atttgatcgc 2798821 gatattttgc cacggtgcgt ctcgagattt ggatgccgtg ttgttcatac agcaaatcga 2798881 caagcttttg gtctgaaagc ggttttgttt tgtcctcttg attgatcagg ttttccagat 2798941 gcgttttgac tgcataattc gacgcatctc catcacctga agcctcggct tttgctgaga 2799001 aaaagagttt catctcaaac agcccgtaag gcgtttgtat tgttttccct ttaatggccc 2799061 ggctcacagt tgattcatga aggcttagac agtctgccac ctctctgaga gtcagcggct 2799121 tcattgcgct tcgccctttc agaaagaaat ccttttggcg tgtgatcagt tcattgataa 2799181 ttctcgtgat tgtctgtttt cgctgccgca gcgcgcggct cagccagcgc cactcctgat 2799241 atttcgcaga taaataggag acagtatcct gacaggagcc ggatgataaa agcgttctgt 2799301 actgcggatg cagatcgatc tcgggaaacg agcgggtatt cagttccgct gcgatgtgcc 2799361 cattttttac ggtgataaaa atgtcaggct caatatacac atcttgctct ggccgggcaa 2799421 acagaaggcc aggtctagga tgaagagccg cgatatcatc tgagatatct tgaatggtat 2799481 gaagcggaat tcccgtctct actgaaagcg ttttccattt tttttgcgca aaagcatcaa 2799541 aatgagctga aaccagcatt tccgcttgtt catttctgtt cggcagccgc tgtaattgaa 2799601 gaaggatgca ttcctgcaaa gatctcgcgc cgattccagc cggttctaac gactggagtt 2799661 ttgccaaaac agcctccgct tccttggccg atacagataa tcgccgtgct gcctcctcta 2799721 tatcttcttc caagtacccg tttgaatcaa gcgaatgaat cagataatta aaaatctttt 2799781 tttcagtgtt tgtcagattc atatcgagtg actgctgttt taacgcatcc tgcaatgttt 2799841 tttgcggatt acttaattga aggcccgctt cctgtgcatt catcctgttt ttgtttgttt 2799901 tatggtaaga tagtggcggt gtgtctgttt cctttcgttc aataagaggg ttttccagtg 2799961 agagctcatc aatgtactcg gcgagttctg ccgaatgata gccaagcagc gtgatggcct 2800021 gcctgagctc ctgtgtcagt tgaggcttta atacttgtac ttgctgaagt ttcatatcca 2800081 tcttgctcac tcccctttct tcattgtaca tgattgagat cacaccgtat acatttatga 2800141 aaaaggagct gccaaagaaa tgtctgaact tttttccgtc ccttatttta ttgagaattt 2800201 aaaacagcat attgaaatga atcagtctga ggataaaatc cacgcgatga acagctacta 2800261 ccgttccgtc gtctcaacac tagtgcagga ccagctgacg aaaaacgcag ttgtcctgaa 2800321 acggattcag catttagatg aagcatacaa caaagtcaaa cgtggagaat caaaataaac 2800381 cttccgaatt cgggaagatg atgatcggtt aaagggctaa cgttcgcatc tataggggaa 2800441 atctgtttat aatgggggaa aaagggagag aacacaatga ctcatcaaat agtaacgact 2800501 caatacggca aagtaaaagg cacaacggaa aacggcgtac ataagtggaa aggcatcccc 2800561 tatgccaagc cgcctgtcgg acaatggcgt tttaaagcac ctgagccgcc tgaagtgtgg 2800621 gaagatgtgc ttgatgccac agcgtacggc tctatttgcc cgcagccgtc tgatttgctg 2800681 tcactttcgt atactgagct gccccgccag tccgaggatt gcttgtatgt caatgtattt 2800741 gcgcctgaca ccccaagtaa aaatcttcct gtcatggtgt ggattcacgg aggcgctttt 2800801 tatctaggag cgggcagtga gccattgtat gacggatcaa aacttgcggc acagggagaa 2800861 gtcattgtcg ttacattgaa ctatcggctg gggccgtttg gctttttgca cttgtcttca 2800921 tttaatgagg cgtattctga taaccttggg cttttagacc aagccgccgc gctgaaatgg 2800981 gtgcgagaga atatttcagc gtttggcggt gatcccgata acgtaacagt atttggagaa 2801041 tccgccggcg ggatgagcat tgccgcgctg cttgctatgc ctgcggcaaa aggcctgttc 2801101 cagaaagcaa tcatggaaag cggcgcttct cgaacgatga cgaaagaaca agcggcgagc 2801161 acctcggcag cctttttaca ggtccttggg attaacgagg gccaactgga taaattgcat 2801221 acggtttctg cggaagattt gctaaaagcg gctgatcagc ttcggattgc agaaaaagaa 2801281 aatatctttc agctgttctt ccagcccgcc cttgatccga aaacgctgcc tgaagaacca 2801341 gaaaaagcga tcgcagaagg ggctgcttcc ggtattccgc tattaattgg aacaacccgt 2801401 gatgaaggat atttattttt caccccggat tcagacgttc attctcagga aacgcttgat 2801461 gcagcgctcg agtatttact agggaagccg ctggcagaga aagttgccga tttgtatccg 2801521 cgttctctgg aaagccaaat tcatatgatg actgatttat tattttggcg ccctgccgtc 2801581 gcctatgcat ccgcacagtc tcattacgcc cctgtctgga tgtacaggtt cgattggcac 2801641 ccgaagaagc cgccgtacaa taaagcgttt cacgcattag agcttccttt tgtctttgga 2801701 aatctggacg gattggaacg aatggcaaaa gcggagatta cggatgaggt gaaacagctt 2801761 tctcacacga tacaatcagc gtggatcacg ttcgccaaaa caggaaaccc aagcaccgaa 2801821 gctgtgaatt ggcctgcgta tcatgaagaa acgagagaga cgctgatttt agactcagag 2801881 attacgatcg aaaacgatcc cgaatctgaa aaaaggcaga agctattccc ttcaaaagga 2801941 gaataaatat ggggaaaaca ggatacattg gtgctgccat tgttgtggca gcttgtatca 2802001 ttattttgtc ggccgtggta tgtttacggg acacagtcta ttaccagcct atgcgctgga 2802061 ctggcatcat actgtttttc gcgggaattg tgatggttcc cgcatactca gcaaaaagaa 2802121 aacccggaaa agagaagtaa ttctcttttc cgggttttta tgtttattat aatcttcccg 2802181 cgcgaatatc gtctgtcatt ccctcataag gagccttcga aatcacttct tcgttgtcga 2802241 ctccttcatt tttcagaaat gtaatttccg caaattcagg tacaacgtat tttggatacg 2802301 tttcatattt ttcgcgggat tctttcatca aatcaatgtg gtcattttgg tagcaaaccg 2802361 taatttcagg atgttcatgc acccatttcg ggaagaaaat aatgccatgc atgcgttttt 2802421 catttggcat aaagtttaat gaaacatccg tgccagtcgg ctctgtccaa gacactttat 2802481 atacgccttc tgtcagtttg acaatattca cttcctgatc tcgaacccag cgtccggcaa 2802541 ccattccgct atgaattcta taatcaattg tatggtcgtt tttaatataa atctcgtatt 2802601 cccatccgtt ttcatacgta taaatcatgt ggcttccgat aaagttttcc atcttacaca 2802661 ctctccttag tcttttactg tacttcataa atgtctagta gaacgtaatc aggggttctt 2802721 tctgcggaac cgataaacaa gcggtcatgg agccattgat agacttcact gcctgtttca 2802781 aacgtcggta ccgtacgaaa ataaacatgc tccggttcaa taatttcccc ggctgccgct 2802841 tgttttcgaa acggcttgct gacttgccgt attccattgt tttcaatgta aatcagttca 2802901 tgatctgctg tttcaatcac atacctggca gataaatctg ttctgccgtt agcgcgaatc 2802961 atttgtgaat cggcaccgcc cggcaaaata cgtcccttta cttccccggt tattgttccc 2803021 gaacgaatcg gaatgaatca tctcagtccc aggcttgtct caccaatcgt gataggcgga 2803081 tcaaccttga tttctaaaga ggcgaatggt tttaaaaccg gcttcttcac gagaaccacc 2803141 tcaccttcag aaaaaatcat gtaactattt acatgttcac tttaacacca ttgcagttaa 2803201 ctgtcaaaca ataggaacat aaaaaaacaa ggactgtttg aagacagtcc ttgtctgaag 2803261 ctagctttga taagcaagat atgtgctgac agtgcttttg gcaagacagg cagaggaatc 2803321 tataatcgga atctcacttt gaatatgatc taacaccgca tttaaatccg tgcaggctga 2803381 aatgatgatg tctgcatgct gactgatttc ttcatatagc gtctgccaca atgcttgtgt 2803441 atgctgcata tgatttggct gtttgattgc ggcgataagc tggttcacag cctgctgcca 2803501 atggtccttg tgaataactt cttgtccatt tcccttcaga actttttggt agatggcgga 2803561 ttggatggtt ggctctgttc ctaaaaccac cgcttttttt gcgggatgcg gaatctcttt 2803621 tatcgtttcc tcaacaatat gcaacatagg aactgacaat gcctgctgaa tctcttcata 2803681 gtagacatgc gccgtattac aaggcagcgc aatgaaatcc acgcctgttt tctcgagctt 2803741 taccgctccg tcgataatcg cttttttcat ctcgtcatgg tcaattggac gatctgcata 2803801 gaagggcgtc gggcatgaat agatcatcat gtgcggatag tcaatatcgt ttgaagcccc 2803861 atacagcttc tgacagtaat caatcacctt atcaataaac ggcgaggtcg atttcggccc 2803921 cattccggct aatattccga tcatcaaatt cattcctttc tacttcgtac ggaccgcttc 2803981 ttcctctgag ccatcctcat agaggataaa gcttttcgca gcatcctcac ctaatgtaaa 2804041 ctcgacttca acagacaatg ctcgcagaaa gaaacgggtt tccgaggaag gaaataactc 2804101 cagtctcagc tgtccggcga tctccaaata aagccgttca ttctcggttg tcacctgtgc 2804161 agccgtccca tcctgcaaca ggtagctgcc aacatagcgg ctgtatatcg ccgtatcaat 2804221 tgcttttttc tttttatcag caggacgttc cgggacatca tatggctggc caaatagaat 2804281 atgttccgcc gccttcagaa tcgcttgttc atattcagta tcctcttcct tattactcaa 2804341 atagatcagc gttttacgat gatcgatata tcggatcatc atcgtcgaat agccgggcca 2804401 tcctccgctg tggctgacaa tccgcccttt ttcaggactg ttttgcagca cccagccaaa 2804461 gccataatca attgtttctc cattgttgag gcgcactgga gaaaacgcag attccttaga 2804521 agccttgctg atgaaatcgt cctgatataa agcctgatca aatcgaaaca aatcgcttgt 2804581 gacagagtta accgtcccat ctccctgtat gccatcgaga tacacaacat agttcgtttc 2804641 ctccagctca tcagggagga cgtatgtttc ggaatgtaca tcatacacat atccatatgc 2804701 ataatgatca attcgctcag gcgaaagcct cctgttatac actcttgttt cattcatgcc 2804761 tgccggtaaa aaaatacttg tttttataaa atccgcatag ctcatgccag atgctttttc 2804821 aatgataacc gccagcagca cataccccgt attgctgtac atccagcctt cattcggttc 2804881 aaaataacca gatagcccct cattcatcag catatcgaca atatcctgat tcaccgcaat 2804941 cttgtgtgaa tcccaattgg caaaaaacca tcccatataa tcaggaagcc ctgacgtatg 2805001 gttcaataaa tgccgaatcg ttacgccctg atacggaaaa ccgggcagcc agcgatccac 2805061 tttatcctca tagccaagaa tccccttctc ctccagcaag atgattccca atgctgtaaa 2805121 aggctttgac aaagacgcta actcaaacaa agagttggtt ttcaacgggc gtttttccgt 2805181 catttccgca tagccaaaag agtggtgata taaaatatcg ccaccctccg cagccagaac 2805241 cgtcccgtta aactgatgtt tttcgcctaa tgtctcaaat aacgtctgaa gatgctttct 2805301 tttattctgc ttcattcctc cacctcccat atctctgtac gttactaacc tactaacgtt 2805361 tcaaatattt tgaaaaatcc ttcagttaga gatccttttt aacccatcac atatacctgc 2805421 cgttcactat tatttagtga aatgagatat tatgatattt tctgaattgt gattaaaaag 2805481 gcaactttat gcccatgcaa cagaaactat aaaaaataca gagaatgaaa agaaacagat 2805541 agatttttta gttctttagg cccgtagtct gcaaatcctt ttatgatttt ctatcaaaca 2805601 aaagaggaaa atagaccagt tgcaatccaa acgagagtct aatagaatga ggtcgaaaag 2805661 taaatcgcgc gggtttgtta ctgataaagc aggcaagacc taaaatgtgt aaagggcaaa 2805721 gtgtatactt tggcgtcacc ccttacatat tttaggtctt tttttattgt gcgtaactaa 2805781 cttgccatct tcaaacagga gggctggaag aagcagaccg ctaacacagt acataaaaaa 2805841 ggagacatga acgatgaaca tcaaaaagtt tgcaaaacaa gcaacagtat taacctttac 2805901 taccgcactg ctggcaggag gcgcaactca agcgtttgcg aaagaaacga accaaaagcc 2805961 atataaggaa acatacggca tttcccatat tacacgccat gatatgctgc aaatccctga 2806021 acagcaaaaa aatgaaaaat atcaagttcc tgaattcgat tcgtccacaa ttaaaaatat 2806081 ctcttctgca aaaggcctgg acgtttggga cagctggcca ttacaaaacg ctgacggcac 2806141 tgtcgcaaac tatcacggct accacatcgt ctttgcatta gccggagatc ctaaaaatgc 2806201 ggatgacaca tcgatttaca tgttctatca aaaagtcggc gaaacttcta ttgacagctg 2806261 gaaaaacgct ggccgcgtct ttaaagacag cgacaaattc gatgcaaatg attctatcct 2806321 aaaagaccaa acacaagaat ggtcaggttc agccacattt acatctgacg gaaaaatccg 2806381 tttattctac actgatttct ccggtaaaca ttacggcaaa caaacactga caactgcaca 2806441 agttaacgta tcagcatcag acagctcttt gaacatcaac ggtgtagagg attataaatc 2806501 aatctttgac ggtgacggaa aaacgtatca aaatgtacag cagttcatcg atgaaggcaa 2806561 ctacagctca ggcgacaacc atacgctgag agatcctcac tacgtagaag ataaaggcca 2806621 caaatactta gtatttgaag caaacactgg aactgaagat ggctaccaag gcgaagaatc 2806681 tttatttaac aaagcatact atggcaaaag cacatcattc ttccgtcaag aaagtcaaaa 2806741 acttctgcaa agcgataaaa aacgcacggc tgagttagca aacggcgctc tcggtatgat 2806801 tgagctaaac gatgattaca cactgaaaaa agtgatgaaa ccgctgattg catctaacac 2806861 agtaacagat gaaattgaac gcgcgaacgt ctttaaaatg aacggcaaat ggtacctgtt 2806921 cactgactcc cgcggatcaa aaatgacgat tgacggcatt acgtctaacg atatttacat 2806981 gcttggttat gtttctaatt ctttaactgg cccatacaag ccgctgaaca aaactggcct 2807041 tgtgttaaaa atggatcttg atcctaacga tgtaaccttt acttactcac acttcgctgt 2807101 acctcaagcg aaaggaaaca atgtcgtgat tacaagctat atgacaaaca gaggattcta 2807161 cgcagacaaa caatcaacgt ttgcgccaag cttcctgctg aacatcaaag gcaagaaaac 2807221 atctgttgtc aaagacagca tccttgaaca aggacaatta acagttaaca aataaaaacg 2807281 caaaagaaaa tgccgatatc ctattggcat tttcttttat ttcttatcaa cataaaggtg 2807341 aatcccatat gaactatata aaagcaggca aatggctaac cgtattccta acctttttag 2807401 gaatattgct gtttatcgac ttatttccaa aagaagaaca tgaccaaaaa acaaaatcaa 2807461 aacagaagcc ggactaccgg gcggcatatc attttacgac gccggataaa tggaaaaatg 2807521 accctcaaaa accgatctat tttgatggca agtatcatta tttctatcta tataaccggg 2807581 attacccaaa aggcaacggc acagaatggc gccatgccgt ctcagaggat ttggtgcact 2807641 ggaccgatga aggcgtggcg attccgaaat atacaaaccc ggacggtgat atttggaccg 2807701 gttccgtcgt ggtggataaa gagaacacag ccggcttcgg gaaaaatgcg cttgtcgcga 2807761 ttgtgacaca gccctcagcc aaagacaaaa aacaggaaca atatttgtgg tacagcacag 2807821 ataagggaaa atcattcaaa ttctacagtg gcaaccccgt tatgcctaat ccgggcacag 2807881 acgatttcag agatccgaaa gtcatatggg atgaccaaga taacaaatgg gtcatggtca 2807941 tggctgaagg atcaaaaatc ggcttttatg aatccgataa tcttaaggac tggcattaca 2808001 caagcggatt cttcccagaa caggcgggaa tggtggaatg tcccgacctc tacatgatgc 2808061 gggcaagcga cggaacgaat aagtgggttc tcggtgccag cgcgaatggc aaaccgtggg 2808121 gcaaaccaaa tacgtacgcc tactggaccg gaagcttcga cggaaaagaa ttcaaagcgg 2808181 atcagactga agcccaatgg cttgactatg gcttcgactg gtatggcggt gtgacgttcg 2808241 aagacagcaa aagcacagat ccattagaaa agcggtatgc gcttgcctgg atgaacaatt 2808301 gggattatgc caacaacacc ccgacaatga agaacggctt taacggcaca gattctgtca 2808361 tacgcgaact ccggctgaag gagcaggatg gaacatacag cctcgtctca cagccgattg 2808421 aagctttgga gcagctgact gtttcaactg acgaaataga ggatcaggat gtgaacggat 2808481 caaaaacatt gtcgataaca ggtgatacgt accagcttga tacggatctt tcttggtcag 2808541 agctaaagaa tgcaggcgtc aggctcagag aatcagaaga ccaaaaacgc catattgatg 2808601 tcggcatttt cgctgaaggc ggctatgctt atgtcaatag agcagccaca aatcagcctg 2808661 acaaaagcaa tacctatgtc gaaagcaaag ctccttatga tgtaaacaaa cgtaaggtgc 2808721 atttgaaaat acttgtcgat aaaacaacga tagaagtatt tgttggcgac gggaaaaccg 2808781 ttttttcaaa tgaagtcttc ccaaagcctg aagataaagg aattaccctt tattctgacg 2808841 gcggcacagc ctccttcaaa aatataacag tgaaacactt tgattcgatt catgaataaa 2808901 aacaggggcg gcgcaggctg cccctgtttt tttattagga gcggtattct ctgttacata 2808961 ttgggcattg taaggaatat aaggctggtt tcaaaggagg aagcgaatgt ctaaacaagg 2809021 aaattttcaa aaatcaatgt cgctgtttga tctgattttg attgggatgg gagccatctt 2809081 tggatcagcg tggctgttcg ctgtcagtaa tgtcgcttca aaagcagggc cctccggcgc 2809141 tttttcctgg atcctcggag gagccattat tttgttaatc gggcttgtat atgcggagct 2809201 cggagccgct ctgccccgta ccggaggcat cattcgatac cccgtttatt cacatggcca 2809261 ccttgtcggc tacttaattt cgtttgtcac gattgtcgct tatacaagct tgatttcaat 2809321 tgaagtgaca gctgtgcgcc agtatgtggc ctattggttt cccggcctga ccattaaagg 2809381 gtctgattcg cctaccattt ccggctggat cttgcagttt gccctattat gcttgttttt 2809441 cctgctgaat tattggagcg tcaaaacctt cgctaaggcg aatttcatca tatcgatttt 2809501 taaatatatt gtgccgatta ccatcattat tgtgctgatc tttcattttc agccggagaa 2809561 tttatccgtt caaggatttg caccgtttgg atttacaggt attcaggctg ccatctcgac 2809621 aggcggcgtc atgtttgcgt atctcggcct gcatccgatt gtatctgtag caggtgaagt 2809681 ccaaaatcca aaacgcaata tcccgatcgc tttaatcatt tgcatcatcg tttcaaccat 2809741 catttatact gttttgcagg tcacctttat tggtgcaatc ccgacagaaa cactgaaaca 2809801 tggctggccg gcaattggcc gggagttctc attgccgttt aaggatattg cggtcatgct 2809861 cgggttaggc tggcttgcaa cgcttgtcat tttagacgcc attctgtctc ccggaggaaa 2809921 cgggaatatc tttatgaata cgacatcccg ccttgtttac gcctgggcgc gtaacggcac 2809981 attatttggc atattctcaa aggtcaataa agatacgggg acaccccgcg cttcgctttg 2810041 gctttcgttt gccctgtcca ttttctggac acttcccttt ccttcgtgga acgcgctcgt 2810101 caatgtctgt tcagtcgcgc tcattctttc atatgcgatt gcacccattt cttcagctgc 2810161 gctgagggtc aacgcgaagg acttaaacag gccgttttat ttaaagggaa tgagcattat 2810221 cgggccgctt tcctttatat ttacagcgtt tatcgtgtac tggtcaggat ggaaaacagt 2810281 ctcctggctg ctcggttcac aactcgtgat gtttttgatc tatctctgtt tcagcaaata 2810341 tacgcctaaa gaagatgtca gccttgctca gcagctgaaa tcagcctggt ggcttatcgg 2810401 gttttatatt atgatgctga tcttttccta catcggttct ttcggacatg gtttagggat 2810461 tatcagcaat cccgtcgacc tcattttagt cgcgatcggc tcacttgcga tttattactg 2810521 ggcaaagtat accgggctcc caaaagccgc cattgattat gataaataaa gaagcaagag 2810581 gttttcttgc ttctttattc tttacaaaca aacatacacg cgataaaatg aatgagagtc 2810641 agtcattact ggaggtgttc ctcatgccaa aacaaacatc gggtaaatac gaaaaaatat 2810701 tgcaggcggc catagaagtc atttctgaaa aaggcctcga caaagcttct atttctgata 2810761 ttgtcaaaaa ggccggcact gcccaaggaa cattctattt gtatttttca tctaaaaatg 2810821 ccctcatacc ggccattgca gaaaatctcc tcacccatac acttgatcaa atcaaaggta 2810881 ggctccatgg ggacgaggat ttttggaccg ttttagatat attaattgat gagacatttc 2810941 tcattacaga acgccataag gatattattg tcctctgtta ttccgggctt gcgatcgacc 2811001 actccatgga aaaatgggag acgatctatc agccttatta ttcctggctt gaaaaaatca 2811061 tcaacaaggc cattgcaaac catgaggtaa cggaaggaat caattcaaaa tggacggcca 2811121 gaacgattat caacttggtc gagaatactg cggaacgatt ctatatcgga tttgaacaag 2811181 atgaaaatgt tgaagtgtat aaaaaggaaa ttttcacttt cttaaaacgg agcttaggta 2811241 ctgcttaaaa aatgactggg taacaccgct cattttttaa tgccctaaaa atgactgacg 2811301 ttcattcata aaatagagag gtgtttcatt tgaattgggt tcttgttttt attgcagggc 2811361 ttttagaggt tgtttgggcc tcttccctca aacatgccga ttcgcttttg gattggatca 2811421 tcatttttat cttaatcgcg gtcagcttta tcctgttgat ccgctcttat caaaaaatcc 2811481 cgatggccgc ggcgtacact gtgtttgtgg gaatcggaac cgtcggaaca tatctgactg 2811541 gaattgttct gggcgaatcc ttctcagcag cccaaatgtt ctttttagct ttattgctgg 2811601 ctggcatttt aggaatgaaa ttatttacga aagaaagcaa atctcagccg ggaggtgaaa 2811661 aataatggca tggtttttat tagtgattgc cggcatagaa gaaattatag ctgccattgc 2811721 catgaaatat atagacggaa caagaaaaaa atggccgatc attgtgatga ctgttggatt 2811781 cggcttatcc ttttactgcc tgtcccaagc gatgatcgtc ctgcctgccg gagtcgcata 2811841 tgccgtctgg actggcattg gaagcattgg tgtttcggcg gtcgggctca tctggtttaa 2811901 ggagcggttt cagctttcac aggtgatttc actttgcctt atcctagccg gcgtcatcgg 2811961 cctgcgtctt acgtcatctt cataaaatca aggcatatac agctgtatat gcctttgcca 2812021 ttaagcttcg tgatgttttt gaagatgaag cggcggcggg atgagccagc ctttgttttt 2812081 tagcagcctt aagtattttg cgccggttgc cgctttcgac atatgaaatt gcccaaacat 2812141 catggcaata tcctcacgaa tcgattgccc catcattttg ctgcatgtca caagacctgc 2812201 agcattttct gctgccgcgg aagccgccac atccggatcg agaaaccgtg caccaggcgg 2812261 aatatcgtta agatctgctg tcggcggttc aggagaagcc ggcggcagcg ccaccccgtt 2812321 ttctttcagg atcgtgctga cctgtttgat ttcatcttgg catttctcaa tagactcacg 2812381 aagcagcttc ttcaggtcgt catcaccgac atgattcaat agcatttggt aattgccgac 2812441 cattttattg cccgccatca cataactcca caagccgaat acctcaccgt aatgcatcgg 2812501 ttcatcctgc ggatttccgc ttaaaatacc catgctcatt ctcctcccat attcaatatt 2812561 gcacatttca taacgtgccc aagcggagga acatttatgt ttcagcggaa aagatttatg 2812621 aaatgaaaca aaacaaaaaa gacaagagtg gcaagttgcc aaaccattgt ctttcctgtt 2812681 gtttgattgg acgcactgaa gggattcgca ccccgacaga caagataccg gaaaccattc 2812741 aagtgctttt tagtatgagt cattgattct gtctttaata aactttaacg agatggcggg 2812801 atgctttgcg gaaaacgaaa tacattttcg gggtcatatt tcgcctttat ttctcgaagc 2812861 cgcgcaaagt ttgcgccata atattctttt ccgaagtttt caatgttttg atctggaaca 2812921 ttaacatatg aacctgctac atatggttgc atcagctgac gcactctttc aactgatgca 2812981 agatttgaat cttcttgtga tttatttttc caactagccg tccattccgt ataaaataat 2813041 ggatggcgcc aaaaaaaggc agtttcgtct ttagggactc tgcttatagc accaccccaa 2813101 ttgataaaaa agaaattggc ttctgttcca gtagcatctt ccaaaaattt tctcatgatt 2813161 gaaatgggtt cgtcagacca aaaatcatga ccccatgccg aggagaattt aacactctga 2813221 tcatttctgc cagggatggg ttcgtcaggg tctaagaaat ctatagcatc tggatagtat 2813281 aatgttttga tatctgcttc tgttggagtt cccgcatgta ataaaggttt taataatcga 2813341 atcaattcag ttttcgaacc gaggaaaatt ccttctgcat gacacaaacc atttattttg 2813401 ctgtaaattt caaggtagca tcctaatcgt tcatctacaa acggagccca tttctgccaa 2813461 gctttaaata ccgtttctaa ttgttcccac ggccagataa tattgaagac ggttgcagtt 2813521 ttaggggcac gatgaacttt gaatgtatat tgggtattat atccaaagtt acctcctcct 2813581 ccgcctctag aagcccatag caaatcctca ttgtgagatt gatctgcgtg aataatcctt 2813641 ccttttgcat ctaccgtttt cagcgcgaga aggttatcac ttataaggcc aatcgatcgt 2813701 gagagtacac caaatccgcc gcccatcgta attcccccga ttccaactgt tgggctatct 2813761 ccaaacggag ccataaaacc gtctcgagct aatcccttta caagcgggcc aacgggaata 2813821 ccagtttgaa cggttgcaat agcgttttct tcatctaaga aaactttatt catgtcactc 2813881 acatcaataa caattcctcc acttactact gaaaggttct tatctaaagc atggcgaccg 2813941 cttctgacac gtaagggcac tttattctca cgagcccatt taatggcatt acttacatcg 2814001 tatgaatttt gcgcaaaaac aaagacaaga ggatagacat ccacataagg gttccaattc 2814061 ttaatagcct ctgtatagcc ggggtctcct ttgaagatta cacgccctgt caactgtgtt 2814121 gatcccatat attatttcac tcccaaagaa attcgattca gatactaaaa tatgcaggag 2814181 ctggataatc gcatagacaa atgatctacg aactataaat ataatacgct aaggcctttt 2814241 tcgtcggtga ggtctgctga gaaacatttt tcaaacaatt ttgagcaaac ttcctgtcca 2814301 atcctccaac aagcgttttt tcttatcgtt tttaggagca gtgtccagtt tttttcggag 2814361 tgaatattcg tttaggccaa aagaaaagag agatgaagaa gtgtttagta ccagaggtat 2814421 acatccatac aacagactct agatcatcat atactgaatg tatgtagaaa ggagacatca 2814481 gctttggcaa aatatcggat tatgaccttt gacggcggcg gtaccttagg tgctttaagt 2814541 ttacaactat taaacagatt ggctaggcaa aacccgaagt taattagtcg aacccatgta 2814601 ttttcgggaa attcaatcgg ttcatttact gcccttgcat tagcaagcgg aagatctccg 2814661 agggaaacac ttcagtattt tgaggatgaa atcctacccg cattcagcat ttcccggcca 2814721 ggcggacctg ttttcaacca acaattaccc tattccggtt ttattaaagc ggtaagaaat 2814781 tttttcccag cagatcttca acttatagat ttaagaaaac gaattgttgt cccatcattc 2814841 aaattatact ctcaaaaact ggaccgttgg actcctgtct tatttcacaa ttttcccggc 2814901 tctccctatt taaatgaaaa agtgagtgat gtcatactgc ggagcagcgg tgctcccgcg 2814961 acgcaacgcg cctatcaaaa ctatgtggac ggatatgtag tagcaacgaa tcccagtaca 2815021 gccagtatcg cgtttgcagt tggtaaagcc aacgtgccat tggatcaaat tgcggtattg 2815081 tccatcggaa caggtgaagc cccgactcgg ttaagaagag atacgagggg atggggaatg 2815141 gtaagtgcag ataacatacg tcccgaaaat ctgaagaacc ttcctccaaa ttggggagtc 2815201 cttttggaca ggtcgcctaa tgaaccttta ctgccatttc ttcagatgat tgctggcggt 2815261 aatgggtact atgaatccat ggtcagtgcg aatcttctgg gagatcgttt tttccggtta 2815321 gatccgcgga ttccgaactt ctccaaaacg gaccctgccg tcgttcccgc tgtcattgaa 2815381 attgcgaaca aaacaaactt acagcctgcg aatcaattta tagagaagaa ctgggggagc 2815441 aaataattat ttattttaaa tcaattctcg cttatacaat tttgtccgag agaagattct 2815501 caaaataaat acaggcaatg ggtagaaccg gattttttta aaggtttgtt aatcacaagc 2815561 taataagatg aatgaaaaaa tcaattcata cttcttcttt tgaaagtgag ggttcaaact 2815621 aaagaatgta attgaaatgt tactctaagg tatgcaattc cctttttcac acaaaaaaag 2815681 acaagagcgg caaatcgcca aacccttgtc tttcctgttg ttctattgga cgcgctcgga 2815741 gggattcgaa cccccgacag acgtggtacc ggaaaccacc gctctatcca actgagctac 2815801 gagcgcatat agactgcgtt atgagaacgt cagcacaact aattatacga taattccttt 2815861 caaataacaa ccctctattt cgagaggccg ttttttaaat agacaaagca tcttaattgg 2815921 caatctgaca tacgatggtt tgaacccctg tatttttggg gaaaatggga aaaagagacg 2815981 actttgcata tcaggccagc tttttgtttg acctttattg accaaaaatg tatcatgtaa 2816041 ctacatactt acctaaaagg tgaaggagga gcattatgaa tttaatacct acagtcattg 2816101 aacaaacgaa ccgcggggaa agagcgtatg acatttattc tcgtctatta aaggatcgta 2816161 tcatcatgct tggatctgcg attgatgaca acgttgcgaa ctccatcgtg tcacagcttt 2816221 tattcttagc agcagaagac cctgaaaaag aaatttctct ttacatcaac agcccgggcg 2816281 gctctattac agccggtatg gcgatctatg ataccatgca gtttattaag ccgaaggtat 2816341 ctacaatttg tatcggtatg gctgcgtcaa tgggcgcgtt cctgcttgca gccggcgaaa 2816401 aaggcaaacg ctatgcgctt ccaaacagtg aagtcatgat tcaccagcct cttggcggtg 2816461 cgcaaggtca agcgacagaa attgaaattg ctgcgaaacg cattctcttg cttcgcgaca 2816521 aattaaacaa agtcctagct gaacgtactg gccagccgct tgaagtgatc gaacgcgaca 2816581 cagaccgtga taacttcaag tctgctgaag aagcgcttga atacggcctg attgacaaaa 2816641 ttttgactca cacagaagac aaaaagtaat aacacaacct gcaagagctg cgtctcttgc 2816701 aggttttttt catttcaagg aattgactcc cttattctat actgctccca ttcctcatgt 2816761 aacagctcaa gcgtcaaatc actcgtctgc ctcacaacca gatcagcacc aagcatcggc 2816821 tgtccttgac cgacaccaac cgcaaacatc cccgcagatt tgattgcaga aatgcctgct 2816881 tctgcgtctt ctattgccgc gcaatcagca ggggaaacat cgagcatcgc tgcagctgtt 2816941 aaaaagatgt caggatcagg cttccccttc gcaagagtcg tcggatcaac aatggcatga 2817001 aaatcatcga taattgccaa gcgtcttaaa atcttaggag cattgcgact tgaagatgct 2817061 aacccgattt ttatattttc gtttttcaat tgacatagaa gcctgccaat ccccggtaaa 2817121 agatcttccg gcgtcaattt gctgatcagc atttgataat cgcgattttt ccgatgcata 2817181 agctcttgtt tctccgcatt tgtatacttt gtttccgccc cgccaaagat caatatgctt 2817241 tcaagtgact cttctctgct gattcctttt agcctttcat tcatgtctct gtcaaaaggg 2817301 atatcgattt gttctgcgat gtgcttccaa gcgagaaaat gatattcagc agtatctgtt 2817361 atcactccgt ctaaatcaaa aatgaccgct ttcatatact aatgcccatc acagcttcat 2817421 aaggtttgag gctaatactc tttaagtcag cccgctcctg cggatagttt gaaattagca 2817481 ctttccaacg ctcatgaatc agttctggag gcgcttcgaa cagagccttt tcttccgata 2817541 aattcacaac gacaagaagc ttttcccctc gatattctcg aaggtaagaa aagacctgcg 2817601 gatcattctc ctgcaacagc tgataatcgc catatatcat aatcttatat tgctttcgta 2817661 attgaatgag cttctgatag taaaagaaaa tcgaatcttg atcttccaaa gactctttca 2817721 cattgatatc ttgatagcgg gaatttaccg gtatccacgg gtctccggct gtgaatcccg 2817781 catgttttcc ggcatcccac tgcatcggtg ttctcgcatg atcccttcct tttatcatca 2817841 cggctttgac aaactctttt tctgacatcg ttttgttttc gacgactagt tcacgatatg 2817901 cattctttat ttcaagatca tcatacatct ccagcggcat atcgctgttg accatgccga 2817961 tttcttctcc ctggtaaata aacggcgttc ctttcatgcc gtgcagaacc gttgcaaatg 2818021 ccttcgcaca ttccttacgc agtttcctgt cattgcccca gcgggaaata accctcggct 2818081 ggtcatggtt ctcaaaataa agggtattcc agccgacatt cattaacccg gtctgccacc 2818141 ttgtcatcgt cttttttaaa gcaatcaaat caaacggctt gatctgccat ttcccatttg 2818201 gcgagttttg ttctttatca atatccatat gttcaaatgt aaagatcata ttcagctctt 2818261 gcctgcttgc atctgtgtac tttttcgcct cttcaatatc agagccgttt gcctctccga 2818321 ctgtcatgca gtcgtaatga gaaagcactt ccctgttcat ctcttgaata aactcatgaa 2818381 gacgtgggcc gttagagtga taacggccga caatatagct gcggctgtga tccgtttcgt 2818441 agtccggaaa atcggtgtat ttagaaatag agccaatcac atccatccgc cagccgtcaa 2818501 cgcctctatc catccagaat ctcattacat cataaacttc ccggcgaacg gcttcgtttt 2818561 cccaatttaa atcaggctgt tttttcgaaa agtagtgcaa ataatactgc cctgttcctt 2818621 catcgtatgt ccacgctgag cctgaaaaga tcgatcccca attattcggc tctgagccgt 2818681 ccggtttagg atctttccaa agataataat cccggtaagg attgtccttc gacttgcggc 2818741 tttcagcaaa ccaagcatgc tcatctgatg tgtggttcac gaccaaatcc atgacgattt 2818801 tcattccgcg tttatggact tcatcaatca gctgaaacat atcttcattt gtcccaaact 2818861 tttcgtacat gtttttgtaa tcgctgatat catatccgtt gtcatcctgc ggggaatcaa 2818921 ataccgggga gagccagatg acatccgccc cgaggttttt gatgtaatcc agcttttgaa 2818981 tcacaccttg caaatctccg aatccatctc cattggcatc ataaaaactg cgcgggtaaa 2819041 tttgataaac gacagcttct ttccaccatt cactcattag gcgttctcct ttcacatcgt 2819101 ccctgtagga caaccggttc ctcataaacg ttcatgtgca gcggctcgcc ttttacaagc 2819161 tcaaaaataa cgcgcttttc gtcaaccgtc acattgatta atcgatttcg ataattgatg 2819221 ttgaatgaat attcgtccca ttctttcggc aaaaacggag caaatgacag cgtctcattc 2819281 gcggtgcgca tgcctgcaaa gccatgaacg attgccagcc agctacccgt cattgaagta 2819341 atatgcaagc cttcttccgt atcatgattg taattatcaa gatcaagcct tgctgtgcgc 2819401 ttatataatt cgagcgcttt cttttccagc ttgagttcgg ctgcgagaat cgcatggaca 2819461 gagggcgata ggcttgattc atgaacagtc atcggctcat aaaattcaaa atttcgccgt 2819521 ttttcttcca ttgtaaaacg gtcattaaaa agataaatgc cttggagaac atctgcctgc 2819581 ttaataaaat tggagcggag aatcttgtcc catgaccaat tctggtaaag aggccgttcc 2819641 gctggatcta attcgtcaac tgtttgcagg tctttgtcca agaacgtgtc atgctgaacg 2819701 aaaatttgca gttcttcact aaatggatag tacatgtgct ggatgatttc tctccagact 2819761 tccaattcta cttcctgcac atccagatgg cggcgtttct ccgctgagat actttcgaga 2819821 ctttgtagag tatactccaa cgtccaagcc gcaatgacat tcgtatacca attgttgtta 2819881 acgttgtttt cgtattcatt cggccctgtg acgccatgga tcatatactt attttttcgt 2819941 ttcgagaagt gaacacggtc ggcccaaaat ctgctgactg ccacaagtac gtctatcccg 2820001 tattcttcca tatagttacg gtcgcctgta taattgatat aattgtagat cgcataacag 2820061 atcgcgccat tgcggtgaat ttcttcaaag gtgatttccc attcgttgtg gcattcatca 2820121 cctgtgaacg tcaccatcgg ataaagtgcc cccttcatcc ccaattttgc agcgtttcgt 2820181 ttggcagcct ccaactgatg atagcgatac aaaagcaggt ttttcgtcac ctccggctcg 2820241 gctgtcgcca aatacatcgg aacggcgtac gcctcagtat cccaatatgc ggcacctcca 2820301 tatttctcgc cagtaaatcc tttcggcccg atattcaaac gggcatcgcc cccgtaatat 2820361 gtcgagaata actgaaagat attgtagcgg attccttgtt gaagctcctc atctccttta 2820421 atctcaatgt ccgcttttgc ccatctttcc ttccatcgat cagtgtgcct ccgttttgca 2820481 tcttcatagc cgttctctac cacatccgcc aaaagctcct tggctttcga taaaagctct 2820541 tcctcccgaa aatcacggga agtcgtgaca atcacaaact ttttcaatga tgccttcgtt 2820601 tgataactgt agcgattctc gacatacatt tcagtcgttt taaagctttc atggacaaaa 2820661 ccctccgtct cgtttgccat tgcggctaat accgtgaagc gcggtgttcc aaatggattt 2820721 tcgatcgttt ttgccgctaa atggccgctg tgagaatcag cacctttcgc ttcctcctgc 2820781 caaaactgtt cttggtagtt agaatcttca tttgccacat ttccatccag gtaaggaaca 2820841 agcgtaatga cagcatctcc cgtcaagcac tccgcttcat aatgaatcgc acagagttct 2820901 tttacagcaa ggctaagaaa ccgctctgac ctgattctga cggttttatc ttgaatgcgg 2820961 acaacagcgc ttcgccgcag aatcccctct ttcatattga gttctacctc aaataattcg 2821021 attgggtttt gatggagatc gattttttca ccgtcaacat ataggcctat gcccataaag 2821081 ttcatcgcat tgatcacttt tccgaaatat tctggatacc cgtttttcca ccagcctact 2821141 cgcgttttgt cggggaacca cacgcctgca atatatgtgc cttggtgact gtcgcctgaa 2821201 tagccttctt caaaattccc tctgaccccc atatagccat tggcaagaga cgtcaggctt 2821261 tccagcagcc gtgtatgctc cttattaaat gtatttgttt tgattttcca ttcatcaatc 2821321 tcaaataacc gctgatttat catcatttcc tcccgaatgt aagtttccat tatcacggcg 2821381 ggttttggtc aaatatctaa atgcaaaaga gatcatcaaa gtaacgccac acgaatggat 2821441 catcaataca gtaatcaaat caaaatgaac catgccgata gcagctgccg caaatgccgg 2821501 cagtgctgat gcgcaaatcg ctatagaggc cgcttccttg aatgatgcaa tagagaccat 2821561 gtttgatatt tttgtgatcc agaggccacc tgcaagaaca aacgttaaca aaagctggat 2821621 catagaaacc accgtatatg ccagcatcat gatcatcggc ttatactgtg ccaaccacaa 2821681 tgtatcgatc aagacctcta catcatggac gtttggtttc tcgagcttaa cgtccatttt 2821741 cgcatagcca acagaaaacc ccgtttcgtt ttgatcggtg atcaccagtt gatcaggttg 2821801 aaatatgatg gcgttttcaa atccagttac tttcaatcgc ccattttcac cgcttgtctc 2821861 atattcatgc ttcatatcga ctgccatcac attctgccca tcttcaatcc tctcagagct 2821921 cttcccgcct gttagttttc cgttcctgat ttgaaaaccc tgcaattgat cagcaaattg 2821981 atcattaact ccttgaatcg ctgacggcat gaaagatgaa acgctgaagc gatccatttt 2822041 cacaaacgaa accgctaacg gcgccattaa gcaggccgtt aaaaacagaa agagaaaaga 2822101 gagctgcagc cagctgaagg tattcccata gcggcaaaca cctgatgggg atgcagccgc 2822161 cttcaggcag cggatgataa agcttttatt ctccagattc ttcattggca ttaccccttt 2822221 gttccgccgg ctgtcaaacc ggacacaaag ttcttttgga gaaaaaagaa tagaacgcat 2822281 atcggcagtg cggctagtat ggcaccggct gcaaatagag ctactttttg ctgctgcgga 2822341 ttagaaataa aggattgtaa tcctacagcg atggtcagcc tttccggtga gcgaagcaga 2822401 aatttcgtca gcaaatagtc gccaaacggt gccataaacg cccaaagcgc ttgtaccgcg 2822461 agcattggct taacaagcgg tagaacaatt gaagcgaaaa tcctcagatg tcccgctccg 2822521 tcaattcgcg cggcttcatc aatttctctc ggcacagtat caaaataacc tttcatcagc 2822581 cacgtgttca tcggaattcc gccgccgata tagatcgctg ttaaaaacca gtattgatcg 2822641 agtgcgccta ttagcatcgc caagacataa aaagcagtca gcgccgccat tgtcggcacc 2822701 atttgaatga ttaaaaagaa tatcaggctc ttttttctgc ctgcaaaccg atagcggctg 2822761 tacgagtacc cggcaagtgt cacaatcgta acctgcaaaa ccatgaccga tagcgcgatg 2822821 acaagtgtat tgctgtacca attgagataa agcgtttcgt caaatagccg cttaaaatga 2822881 tccaatgtcc aagaacccga aaaatcgagc tgaaaagccg ccgaattccc cacacggaag 2822941 gctgatgatg ccgtaatcag caacggatat ataatgacaa tacttaaaag cgtcaaaaat 2823001 aaatacgtac agattttatt aagcattctg gcagtgctcg cgttcaccta cataacctcc 2823061 tcattgccaa aagcattcga ttttttgaaa gcaatcagtg aaattccaat gacaatgaaa 2823121 gaaattaaca gtgtcacagc cgccgcaacg gaatattggg gtgatgtgcc tgttgtcagt 2823181 ttataaatcc acgaaattaa gatatcggtc gatccggccc cggctcccgc actgcctggc 2823241 cctccctcat taaataaata gatgatcgag aaattattga aattaaacgt atactgagta 2823301 atcatcacgg gtgctgtggc aaataaaatc atcgggaatg taatatgccg aaaacgctga 2823361 ataaaagtgg ccccgtcaat ctttgccgct tcatacaatt cacctggaat cgcctgaagc 2823421 actcccgtta ccatgacata tatatatgga aagccgagcc acgtttgaat cataatgagg 2823481 gctgtctttg tccagaaagg atcggtcttc cacgcgatcg caggcagctc gacaaacggc 2823541 aggtgattga ataatggtat cacctgtgca ttcaccgctc ctatgctgtc gttaaacatg 2823601 ttggaaaaac tcatgattgt aataaacgcc ggaacagccc atggaaataa gaaaatcatt 2823661 cgaaatatcc gcttgccttt tataaaatcc tgattgacga aaagtgccgt cacaatacct 2823721 aaaatgattt gcagcgttgt tgcacagatt gtccagataa ccgtccagcc cagtacattc 2823781 acaaatgttt cacgatagga gccaaggaaa aaaatattta agaaattttt aaacccgacc 2823841 cagtcaatca gacgattagg cggaatatga taaaaatcat agtttgttaa tgcaacaaac 2823901 agagtcacca aaaccggaaa aataatcaca aacaccatca tgatatatgc cggcagtgta 2823961 aatagatacg gaaaaccttt atcgcccgca tgacagatca tatccttggc tgttgtattg 2824021 acttccaaac ccgccgcttt catagcggcg gtcttacgtg aatcatgaat attaaagata 2824081 tagaacatga ggaaaatcat tgtcacgatc aattgcagcg tgccttcaat cagcataaac 2824141 agcgagtgat cttcaccggg aacacttccc aatgtcatca atccggttag cgcctgtata 2824201 ccgaaaacgc ataattcaaa agcaaacaag cctgtgatgg caagaaataa gagccccttt 2824261 gacaactgct gattcgcaat ctgcccaagt cctggaatga tcgataaaag ccctgccttt 2824321 cgtttttgct ttgtaagtgt gtgatgttta ttcatttttc cgccctctat tcttccggac 2824381 gctatcccgc cgttttattt cacatacttt tctttaatat tttcctttat gacgtttaca 2824441 gcatcattcg ctgatgtttg tgtcgatttt tttcctgaag ctgcatcaaa aattaaactt 2824501 tccgctcctg tccatacttc agccatttcc ggaatatttg gagtcggcgt tgctgtttca 2824561 tattgtttaa tcacagctga cgtcagttca ttcttttgct catcggcttt cttccttgca 2824621 gccgtgttgg ccggaacttc gtttgtatcc tcataaaaag cgtaagcatt ggcatcattt 2824681 gcagcatact caagccattt ttcagccagc tcgggctctt ttgtatattt cgaggcaacc 2824741 cagcccttcc cgccagcaaa aggggcgtat tcttctccat ttggcaatgt cggaatggga 2824801 gccgctccgt agttcaattt agcctcttta tagttggcag ctgaccaagg accgccaatg 2824861 atcgcagccg ctttgccttc taaaaacatc tgctgaataa agtcgtctgc gcttgaattg 2824921 tcttgcattc ctttcggcca atatgtctca aaccatttct ccgcatattt caccgcttct 2824981 acagcccctt tattgttcag gccgatgtcc ccggaatctg tgccgttttt tccaaacaca 2825041 tatccgccgt atccagccaa taagccgtac gacatataaa agtcagtcca ttttgctaaa 2825101 aatccggttg attttccttt ttccgaagca aacgcgaatc gaggatcttc cgttaacttt 2825161 tcaaggtctt taaatgtttt tggcgctgtt tttaaaagat ctttgttgta atacaaaata 2825221 agtgtctcaa tgactagcgg cattccgtac actttgccgt caactgtcac ctgctgcatt 2825281 tctttatcac caaagctttt tgtgttagat ggcttaatat caagtaaatg tccttgttgt 2825341 cccaaaccgc cgatccggtc atatgcagca agcataacat caggcgcatt acccgccggg 2825401 ccatcaagag gaagcgcttc taactgttcg aacatttgct tttcaacaat ttttactgtg 2825461 acatcatttt ctttttcgaa ctttgttttt atgctttcaa tgtattcttt atacgtttct 2825521 tcgacagaca cagtcagcac ctttttgcca tcagagcttg ctggattttt tgaacttgag 2825581 caggcggcaa ggccgattgc caggaatgat gccgccaata tggcgaaccc cttttttaaa 2825641 agaaccatct cttttcctcc ttctatttac gaaactataa caattgtatt gtcctataga 2825701 aagcggttac aacaactttc gatttgttac cgataacaga atgttataca ggggcggcag 2825761 cactcaaaat caaaaattct cccggctgaa cggcaatgac atcgtgatgc tgtagcggct 2825821 gctctgtcca tgcatcacag attttcttat tcctatcaat attcaactct cgtaaactga 2825881 cgtgttgaac cacattccct tgattaaaga aataaatcag tattttttca tcaagagtcc 2825941 gcgaaaagct aatgaaatca tttttgtcgt ccagcagatt ccactcaaga tgtccttcag 2826001 tcaataaagt gttttcctgc ttgcgtaaag caattaaccg tttcataaat tgcagcatgt 2826061 cttggttttg cttctctttt tcccaaacca tacatttccg gcataatgga tcattttcgc 2826121 cgttcagccc gatttccgtt ccgtaataaa tgcatggtga gcctgtctgg gcaaacataa 2826181 aggccagcaa cgcgcgtgct ttcttctcat cattgcggca tctggtcaaa aggcgctttg 2826241 tatcatggct atccagtaaa ttaaacatca cctcattggc ctgcttcatt ccattcatca 2826301 aatgtgcatt gacacggtga gccatacgtg aagctgagat cgtctggtca gcaaagtatt 2826361 caatcatagg ctctgtaaaa gggtaattca tcgccgcatg aaattcatcc cctctaagcc 2826421 agggttcggc agaatgccag atctcaccta aaatataaac atcaggcttt tcagtagata 2826481 cagcctgcct aaatgtcttc caaaaaacgt gatccacttc atttgcgaca tccaaacgcc 2826541 agccgtcaat gtcaaattcg cgaatccagt acaaagcaat atcaagcaaa tatttctgca 2826601 cctcgggatt agccgtgttt agcttcggca tatcagctgt aaaagcaaat ctgtcataat 2826661 tgtcgtctgt gacgggaaaa gagtgaatat ggaaccagtc cttatagcgg gattgatctc 2826721 cgtttttgac gacatcctgc cattgcggag acgcgcttcc tatatggtta aaaaccgcat 2826781 caagcataat tctcatcccc cgctgatgca gctggctgac caatgtacga aaaagctcag 2826841 gatccccgaa atgcggatca atagaaaagt aatccagcgt gtcgtattta tgattagaag 2826901 gcgcggaaaa gatcggtgtc agataaatgc cgttcacccc taaatcctct aaataatcaa 2826961 gcttgtcaac aattccttgt aaatcccctc caaaaaaatc attgacgtcc gggtccttgc 2827021 tcccccacgg caatgcattc ttcggtgaca agtcttctct tccatttgca aaacgctccg 2827081 gaaaaatttg ataccaaacc gttgacttga cccattcagg cgcttgaaat gtatcagcct 2827141 cgtgaacaaa cggaaattta aagtaataat gaatcgtttc cagtgttttt tcgttataag 2827201 ggcatacacc cgaacttccg aaaaagatgt cttcatgatc gtctgttaca acaaacgcat 2827261 attgtaaacg cctaaatggc ggcaccactt cagcaaacca atagtcatgc atttctgtag 2827321 cagcaatttt cctcatcggc tgctcgtttg ccgaccattt gccgtcgttg tactcatagg 2827381 gatcacccca aatgaatcga atgtgatctg catcaccttt tttcgtccga atcttgatat 2827441 gcacagtccg cccatcataa gaataagcat ctgtgctgaa tggctggtga tgaatcgctg 2827501 catattccat catgtttccc cctttgattt ccgttttatt gaagccggct catagtttga 2827561 aagtatcatg atgaaattgt gggaacaatc cttttcaccc tgttaccgat aacagaataa 2827621 ggcgcttaca gcgttgattc tcgtacaatt aactctggtt caaaaaatag acttccttgt 2827681 gcagcgccgt cttcattcat ttttttcagc aacattttcg cacaggcttc ccccatttca 2827741 acaacaggct gtctgaccgt agtcaagcgc ggcgaggaga tgcgatcaag aaacacaccg 2827801 tcattcccgg taaccgcaac gtcttctgga attcgctttc caagggattg cgccgcacga 2827861 atgacgccga gcgcgattcg atcagatgcg cagacaaatg cggcctgatt gtccatggat 2827921 ttcagcagtt ctcttgcaag gcattcactt ttcttagaac tgttgtcgat ccgaaacata 2827981 ttcgattttt taaagctttt attcatcgcc cgtatatacc cctgttctct tgcacgttcg 2828041 aaaggctcat ctaaatcaat gccaaaaaag acaacttccc gctcccccag ccccataaca 2828101 tggcgggttg ccataaaagt gcctttctcg ttattcacat cgataaagtc atagcccatt 2828161 tcattttgtc caaatacgac gagcggcttc tcaaaagctt ttattacacc ttcaaaatcg 2828221 ttctttctca agccggtggc aataatgccg tcacattggc caatattaag agaatttctt 2828281 gtcacaagct ggagagcata gtgattgcga tccagctccc tgctgattcc tgtcagcagg 2828341 ttcatgtaat atggttctgt cgtatccatt tcctcaagta tcaatagttt cacaacctgt 2828401 gttctgtttt gcacgagcgc tctcgccgca taattaggga tgtaattcag ctctttcatc 2828461 gcagaatgaa caagcttttt caattcatcc gtcaccgtct cagggtgatt gatcactcgt 2828521 gataccgtca ttttcgaaac atttgctttt ttcgccacat ctgacaatgt tgccattttc 2828581 atcccctcct tatctgtgct tattatccaa actagtgata aagtcctcta ttactgctaa 2828641 atatacgatg caggccaaag agaaataaaa aagagatttc ccttaaggaa acctcacttt 2828701 gttaaaaaca ctcgattttt catggattca tacgctaggt ggcagactca ttctctccac 2828761 ttccatcaga aaatctcttt tttaaatttc tgtccacttt ttttctaaaa tcggataaga 2828821 ataattttgc atttgctcaa ttaactcatc cggccgtgac gagctgtgaa tcagttttag 2828881 gtgcgattcg ttagaaaacc cttcttgaat gctgtatttc accattttca tcattggttc 2828941 aaaatatccg tttacattgt acagtccaat tggcttttgg tggatgccga tctgtgccca 2829001 gcacagcact tcaaataatt cttcatatgt accgaagccg cccggcatcg agataaagcc 2829061 gtccgccagc tcgctcattt tagcctttcg ttcatgcatc ccgtttactt caatcagctc 2829121 agtcagattc tgatggacaa cctccccgct gaacaaaccg ctcggcatga ccccgattgc 2829181 agttccgccg ttttccataa tcgcgtcagc aatcgtgccc atcaagccta cgcgggagcc 2829241 cccatagaca aggccgattc cctgctcagc catatacacg ccaagctctg ccgcttttct 2829301 tttatacgct tcatttcccc cagggtttga tcccgcaaat acacaaatgg ttttcatctt 2829361 gtcatctccg catctatata tcgtgttaaa cattcaaaaa cacactatat attgtcccat 2829421 cttcatgtga taatatcaat atgaaataca taaagaatgc aggagtgatg aggttgcagc 2829481 tggctgatgc agaaaaatgg atgaaagagt tttacgaaaa aagaggctgg acagaatacg 2829541 gaccttttat tcgcgtcggc tttttaatgg aggaagccgg agaactggcc cgggctgtca 2829601 gggcgtatga aatcggcaga gaccggccgg atgagaaaga atcgtcacgc gctgagcaaa 2829661 aacaagaatt gattgaagaa atgggagatg tcatcggaaa tatcgccatt cttgctgata 2829721 tgtatggtgt ctctttagaa gacgtcatga aggcccacca agaaaaactg acaaaacgat 2829781 ttgagcatgc ataaaaaagc ggccgcgatg gccgcttttt ttaacctgtg atttcatcat 2829841 ggtgatcaaa gaaatgctgc tttcctattt tgtgaaaaag gcctgtttta tgcagtagct 2829901 ccttcggctg cgattgcaat cctacaatca tcagctttcc attgtggcgt ttaattcgat 2829961 tcataatgtt cccaagcacc gcttcagctg acgtatccat atagtgcacc ttattcatga 2830021 gcagaataag ggttttcggt tttttctgta catgctccag caatgacgat tcaagggaat 2830081 caattgatcc gaaaaacagc ggcccttcta tggcatacat gctgacagat ggatcttctc 2830141 tcttcgccag aacaggatgc gtttcctgat tgtggatgcg ggtcgcttcg ctcattcttc 2830201 tgataaagaa cacgaatgca agcagcaatc cggttgccac accgatgatt aagtcaaaca 2830261 gaaccgtaag ggcgaaggtc gccgccaaaa taaaggaatc agcatttttc agtctcagca 2830321 tgtttgcgac ttccttgcgc tcactcatat tccatgcgac caccatgaga atcggtgcca 2830381 tactggcgag cggcacatgg gacgcataag gcgcaaatac aagcaggaca aggagaacga 2830441 ctacgccgtg aacgacgccg gaaactgggg aaaccgctcc gttttttata ttggtcgccg 2830501 ttctcgcaat cgctcctgta gccgggattc cgccaaacag gggcgctgcc atattcgcaa 2830561 tcccctggcc gacaagctcc ttgttgctgt catgctttga gcccttcatg ttatcagcga 2830621 ccattgcgga caaaatcgac tcaagtcctc caagaagcgc gatgacaagc gcagccggaa 2830681 acagcataac cattttatcc aaagtaagct caggaaactg aaattccggc aaatggcggg 2830741 ggatttctcc ataagttgac ccgatcgttg ccatgcggtc agggaaaaag acaaccgcga 2830801 ccactgtgga aataagaagc gccaacaaag cgcccggcac tttaggcatc accttggcgg 2830861 atacaagcaa aatgacgagc ccgatcacag ctgtcaaaat ggcatacacg ttaaaggtgc 2830921 cgagctgctg cacaatttca aacatgttgt gatgaaagtt ctcatgtttt tcaacatttc 2830981 tcaatccgag aaaattagcg atttgttccg taaagatcag cacggcaatt ccggctgtaa 2831041 aaccgacgat aacgggtttg ggcacgaatt tcattatttt tccgagctta aacagcccaa 2831101 acagtaccag catcactcct gccataaacc ccgcaatcag cagattttcc aagccgtact 2831161 gcatgataat gccgaataaa atcgggacaa aggcgcccgt cggaccgcca atctgatatt 2831221 ttgatcctcc aaacaaagaa atacaaatcc ctgctataac aacagtgtat agcccatatt 2831281 caggctcgac tcccgaggca atggcaaacg ccattcctaa aggaattgcc acgacaccta 2831341 ctacgatacc tgcaatcaag tctttctgaa atttctgcaa attgtatccc ttgaatctcc 2831401 ctgagaatcg catattttgt tataacctcc cttatgagtg attgtttata agctcagttt 2831461 cataaccgtt aatgaccaca tcaagttttc ctgtttcagg gtgaatgaca agcccgtgaa 2831521 ccggcacttt tttcggaagc agcggatggt tcttaatcat gttcacactg tgggaaacgc 2831581 tttcttccac gctgtgaaaa ccagtcagcc acgttttcaa atcgagtccg gcactcgtca 2831641 gcaaattcag gcagctatcc tccaccccgc gttcctttgc tttctcaaga atcgaggacg 2831701 cattcagccc tgacattccg cattcatgat ggccgacaat gcatacctct tcagcctgca 2831761 attcataaat cgcgaccagt atgcttcgca tcacgcttcc aaatgggtga gaaacgatgg 2831821 ctcccgcgtt ttttacaatt ttagcatcac cgtttttaag ccccattgct tgcggaagaa 2831881 gttctgtaag ccttgtatcc atacaggtga caatgacgag ctttttcgaa ggaaactttg 2831941 tcgttttgta cggttcatac ttcttctcac tgacaaaccg ctgattgtgt tccaaaattg 2832001 atgttaaaga aaccatttga ttcatctccc atccatatga ttttgcaagc cttcttaccc 2832061 agcttacagt aaggaattat agcataggaa taagccaaga aaaggttttc aaaaaaagac 2832121 actataattg gactgtagaa tcaaaacata aacatttata tctttcaaag ataataaaat 2832181 ttatatttaa tgcatcctat aatccggctg cagttcgtat atcgatgatt tgtctgacaa 2832241 aaaatatggg tgaattctga taattaaaaa acttttttaa gcagatttag ctgttcgatc 2832301 ttcattttaa gttcaaaaga accagaaatt aaaaaaacgc agctatattt ttaacatcta 2832361 tttattttcg atataatgaa ttagacaaca gccataaagg gggagccttg ttgaaaccat 2832421 ttgtatttat cacaaaaccg attcctgaag agattgaagc attcatcggt gaacattgcc 2832481 gttatgaagt atggcaggag gatacgcttc cgagtgacgt gctatttgaa aaattaaaag 2832541 aagcggaggg gcttttaaca tcagggacgt ccggaccgtc aatcaatcgt gagttgctgg 2832601 aacacgcgcc taagctcaaa gtggtcagca accaatcagt aggctacgat aacttcgata 2832661 tagaagcaat gaaagaaaga ggagtcgtcg ggactcatac accttataca ctggatgaca 2832721 cagttgcaga tctggctttt tcactgattc tgtcttccgc cagacgtgtt gccgaactgg 2832781 accgttttgt cagagcagga aaatggggaa ccgtggaaga ggaagcgctt ttcggaattg 2832841 atgttcatca tcaaacgtta ggcattatcg gcatgggcag aattggagaa caagcagcga 2832901 gacgcgccaa atttggtttt gatatggaag tgctttatca taaccgacat cgcaaacaag 2832961 aaacagaaga cagcatcggc gttaagtatg cagagcttga tacattgctg gagcaatctg 2833021 attttattct tctcattacg ccgctgactg atgaaaccta tcacatgata ggagaacgcg 2833081 aatttaagtt gatgaagaat tcagcaattt tcgtcaatat ttcccgggga aagacagttg 2833141 atgaaaaagc actgattcgc gctcttcagg aaggctggat caggggagcc ggcttagatg 2833201 tatacgaaaa agagcctgtc acccaagata atccgctcct gcagctggat aatgtcacgc 2833261 tgcttcctca tatcggttca gcaacagcta aagtgcgctt caacatgtgc aaacaggccg 2833321 ccgaaaatat gctcgcagcg atccaagggc aaacaccgaa aaatcttaca agagaatttc 2833381 aataaatcaa aaatccggtc tgataacaga ccggatttca tattacatac gctgaagaac 2833441 agcacgctta taaatatgac gggtgacgat ataataaaga gcctggaata caaaataaat 2833501 gaagatgaca attacggcct caagaaataa attggaattc agcatattac ttaacgctgc 2833561 atacgcaaag cccgcgtgaa tcgtacctgc gataaatggg atgaagaata aaaatcctat 2833621 ttgctttcca aggatcgagt gaatctcttt gtccgtaacc cctatcctct ttaacgctaa 2833681 cacctgcact cccgtatctt ctatttccgt aaacatccgc aaatacagca tgcttccttg 2833741 cacgataaaa aacagcacgc tgacaaacag accaataaac agcattaatg caactccctg 2833801 cttcacaatt tgataactag gagcacgtgt ttgaaaatca gatgtatgtt ctttcggcac 2833861 catgttttca agcttttcag agacatccac cgtctcctgc caatgctcaa gctcataacc 2833921 taccattctc atctgttcct tcagcggcac atcctgtgac agactgtcaa agctcttttc 2833981 gctgacaacc aataaacggc tgactccatc gacagacatc aatatccctt tgttttgctg 2834041 ctttttcatg acataggaaa gggtttttcc tgacttcata tgaaatgctg ctgtttcccc 2834101 ttctccaaat gtgtctttca ccatcatttg aaaagaaaca ttaataaatg cttcattttc 2834161 ttgtaaatga ataactggga accctttttc ctttgcgact tgattataga ctttttctga 2834221 aatcagcaaa gcttcagctt ccatcttctt atttccatac ggcaagtctg actgaaaagt 2834281 gacaggaatc cctgtggcat ccaccttata cgtgataaca gcatgagctt ttttcaatgt 2834341 attctcagcc gtctcaggct tcatgacctg aaagcgggaa gcatcctttt ccacccagga 2834401 aacagactga ggaatgcttt gctcctcctg cctttgtaaa tcggaataaa acatatagat 2834461 gacacctgta gctgttagta tgaccgctgt aatgacagag gttaaaaaca gcatgcgtgc 2834521 atgatccttc agcctgaata tcatgttgga acgcacaatg atatttgtgc ctttgtagaa 2834581 gctgtgtttc tttcggtaca gcatgcggaa aaatgccaca ctgctttggg taaaaaagaa 2834641 atacgtgcca attaacacta aaatcaaaat tggaaaaacc cgaaacatca tgtcaattgc 2834701 attggctgtt gcagatagat aataaccgct gccaagacat agcaaagaca atacagtgag 2834761 ccatttcgaa taaactggca aacttttcgg ctttttggct gatttaatca gttcaatgat 2834821 ttccagcttc cgaatccgtc ccagtgataa aatgagcagc gtctgaaaca ggatgagaaa 2834881 gccggcaatt gtcatcacaa acgctttcgg cacaatggca aacgaaatcg gcaccttcac 2834941 gctgagcatc catgtcatga tcataaaaaa cagttttgaa aataacaggc ctgctccaat 2835001 gccggccgca atcgccgcaa gagaaataag tgactgctca taataaatca tcttgcgaag 2835061 ctgctgcttt gatgtgccaa acagtgtcag cagcccaaac tctttctttc ttgcctgcaa 2835121 aaacgctgaa ttggaatatg tgatgaaaaa tatacaaaac acaatgatga cgacaagagc 2835181 tgcgctcaag catgttttga caaggcttcc tccatatata ttgtcttcat tgacatcagg 2835241 atgaaaaata aatgatgtga agacaaaaaa caccgaaacg gcaaacacac agcttaaaaa 2835301 gtaggccaca taccgttgca gattcccaag aatgttttta cgggcgatag ttctcaaatt 2835361 catgaaaatc gcctcccaac acactcaagg tatccaatat actttgataa aacacctgcc 2835421 tgtttgttcc tctgtgaatc tctgaaaaga aacgtccgtc tttaataaaa acaatccgtt 2835481 tacagaaact tgctgctgtg gcatcatgcg taaccaacaa aatcgtcgct tccttttcct 2835541 cattcagctg agccagtgtg ttcatcactt gctttgccga ttttgagtcg aggtttcctg 2835601 tcggttcatc ggcaagaatg agcgccggat tgtgaataat cgctctggca caagctgccc 2835661 gctgctgctg tccgcccgac acctcatatg tgcggtgatc gagaatatgc tttatttgca 2835721 gcgtatccgc cagttcatcc aatcgagctt ccatttctct cagctttacc ttatccaatg 2835781 cgagcggcaa gagaatattt tcacgaatcg tcagcgtatc aagcagatta aaatcctgaa 2835841 agacgaagcc gagttctctt ctgcgaaaca aagccagctc ttggtccttt aacgttttcg 2835901 gctgaatgcc gttgatcatc atctcgccct gggtcggctt atcaatggta gccagcaaat 2835961 tcaaaagcgt ggtttttccg cttcccgacg gccccataat cccgacaaat tctccttttg 2836021 acacactgag atcaaaggcg ctgagcgctt ggtatgatat tgttccttta tttgaatagt 2836081 atgttttcga taggttcgtt gtttgcaaca cgttcatgtt ctgctcctcc tttttcttta 2836141 ttataaaaag gaagtcagca tcctcccatc gaactttctt gcaattccgc tccccaatct 2836201 tacaatgctg tcacattcac gagggtgtca cttgaaaaca cgatggtcat cacagtgcca 2836261 gccccttctt ttgattccgc atacagctta tggccgagac ggctgcacac ctgttttgct 2836321 aaataaaggc ccattccagt tgcctctttc atggttcgtc cgttttctcc ggtaaaaaac 2836381 gcgtcaaaaa tccgcggcag atcctgcggc ggtatgccga ttccttcgtc ggcaaccgac 2836441 aagcgcgtct catgtccctg tgtttcaatc cggattgtaa tagggtctcc cacaccttgc 2836501 tttgaatatt ttaaggcgtt gaaaaggatt tgctcaacaa caaaggaaag ccacttttga 2836561 tcactggaaa tctgaacggc atttggcggc acatgtaatg ttggaaaaag gcgccgcttg 2836621 ataaactgac gtttttcctg attgatcagt gaacgaacca tttctgccaa atcaaaggtt 2836681 tgcggcttta catcaaatgc aaattcctcc agccgggccg tttgcagcat catatcaaga 2836741 ccgtggcgaa atctctcatt ctcatcctcc agctcctcta aaaacgtcgg aaaagaggat 2836801 gaggttccgt tttttccttc ctgaatcatt aaggatatga cagataccgg tgttttcata 2836861 tggtggaccc attggttggt gaaggtgtaa tgctgttttt gctgattgat atattgtgag 2836921 agcctgcttt cgtattgctg cccgagtgcg ttgatcatct tcgtccaaag cgcttgctct 2836981 cctgttcttg gctttctggc tttcaaagac tgtccgatgt cattcgaaga agaggcttgt 2837041 tctgcaagct ttttaacata tgtgagaaag gaaaattgcc gaacataatc agcagcaaaa 2837101 cctgcggcta aaagagtacc gggcaaaatc catatgtaca tcatattttc tttggaaggt 2837161 tctgcgccgc tctctacaat gcttaaatac gcaatcagca tggcggaccc tatccctaat 2837221 aatgaaaata gaataatggc taagcggtcg atgagataag tctttaacat tccgcttcat 2837281 ccttccgatt gacttgaaat tgataacctt gtcctctgat tgtggaaatg caatctgtca 2837341 gtcctgcatt ctccagtttt ctccgcagcc gattgacatt gaccgttaac gtattgtcat 2837401 cgacaaaatc aacgtcatcc cataacgcct ccaatagttc atcacgagag acaatttttt 2837461 tatgctccct cacaaaaatc gagagaagct ggaattcttt ttgggaaaac aaaatccgga 2837521 cgctgttcca ttcggcctca ttctgatcag gataaatcgt cagcccgcca agctccacta 2837581 ttctagattc ctgcggcaaa gagggcgaat attcaccata tgtgcggcgc aggacgcttt 2837641 tgattttggc catcactacc tctagatgga acggctttgt gatataatca tcgccgccat 2837701 tttcaatcgc cattacctga ttcagctcat cggtccgtgc cgatataaag ataatcggcg 2837761 cattggaaat ggtacggatt tgcctgcacc aataaaaccc gtcaaaaaaa ggcaggttga 2837821 tatcaagcag cacaagatca ggcttcattt ctgcaaattc caattttata tcattcagct 2837881 gttcagcaat tttcacttca tatccgtatt tttgaagatg accgcccagc aaagaagcaa 2837941 tccgctcatc atcttccaca agcaaaatcc gatacacgtt gatccccctt atatgtacat 2838001 cacgatgatt tttctagaag attccaaaat tattatagca tgtgcggaat agtaaatcgg 2838061 tctttttctt tttgttatga tagaatgata aaggtaaaat tttcataata ggcaggtgtc 2838121 gtgatgaaga aaatcatgct gtttctggca atgacgtcaa ttctttcagc atgtcagccc 2838181 aactataccg ggaaatacat agaaattggg gatacactaa ctgactatac caaagagtgc 2838241 tttaaagaga atgaaattcc ttataaatac gaaaagggaa aactgtatat cccagaagac 2838301 gcatttgata cagcaatcta cacttgttca taagaaaaag cttgcagata acctgcaagc 2838361 ttttcacgtt acaaaaaatg agtatttaat ttctcttcaa atcctgaagg gccgatgtcg 2838421 cttttttgaa tgttaccgcc gttttcataa atcgtaaaat ggcgctctga catgaccatc 2838481 cttccgctcg gcgtcagctt tgaggcaagc agggatttgt taaaaggaga tttttcatga 2838541 gagtgaatga tgtccttcat gttatctaaa tcaccgagat cactctcttc aagggtaaag 2838601 gcgtacccaa tttgccagcc ttctcctttg tccatcagca gaacatagct gcccttttct 2838661 gtctcttcct ttttgattcg gaatgacccg actggtgact gtaccgtttc tccggaaagc 2838721 ggtatcggct ggagcgccag gttgatgccg aagccgatat caacgaggta atcgccgttt 2838781 tccgcagaca gccatacagc agcatgcgtc ccttctagtg cccatccctc ttgatcgcct 2838841 gcataaaccg ttcctcgaat gagcttcaca tgaaacccgg cctcacgcaa gacaaaataa 2838901 aggaaaccat ttagatcgta gcataggccg ccgtgctgat ctttgagcag acgtcgccat 2838961 agctcttctt ttgtgatctt ataattctct tttgcaagta cggcacggtt ttcgaatgga 2839021 aaacggtatg ccattgcttt aagaaaaagg ggaagatcgc cgaagctgac atggtctttc 2839081 tcccagccga ttttctgaaa gcagtctttt agaaagtcac tcatttttat cacctaaact 2839141 tcttcttgaa cgtaagcagc cagcttctcc agcgcctctt gttcatcttc tccctgggca 2839201 atcaaggtaa cctcagtgcc tgtgcttacc gcaaggctca tcagccccat gatgcttttg 2839261 gcgtttactt ttttcccatc cttctcaaga aacacatctg acgtaaaccg gtttgcttct 2839321 tgtacaaaca aagcagcagg acgtgcttgc agtcctgtct ttaatcgaac ttccactttc 2839381 tgttgaacca taagatctcc ccttttcttt acggttattt taaagtgacg gtttgccctg 2839441 tccgcagctg ttctgcgatt tcgtcaagtt ttctcagcct gtgattgatc cctgatttgc 2839501 tgattttccc gcttgctacc atttccccta gctctttcag cgtcacttcc tgataatcaa 2839561 tccgcagctg cgcaatttcc cgaagttttt caggcagcgc ctccaggccg attctttcat 2839621 cgatgtattt aatattttcc acctgtctca gcgatgcgcc gatcgttttg tttaagttgg 2839681 ctgtttcaca attgacgagg cggttgaccg aatttctcat gtcccgaacg attctgacat 2839741 cctcaaatcg cagaagcgaa ttgtgagcgc caattacgtt cagaaactct gtaatctttt 2839801 cagcctcttt taaataggta atatagcctt ttttccgttc aagcgttttg ctgtttaact 2839861 gaaactcatt taacaggtca cataatgaat cgttatgctc cttataaaga gagaagattt 2839921 ctaaatgata cgaggaggtt tccgggttat tgaccgaacc tcctgccaaa aatgctcctc 2839981 tcatataaga acgcttgcag catctctttt tgaccagctc tttcgaaata cttcgttcaa 2840041 acacaaaatt ctccccgagt atttttaaat cctctaagat cgcttttgca ttttctgaaa 2840101 aacgcacaat atagacgtta ttctttttca gccgcatttt ctttctgacc agcagctcga 2840161 ccgacacatc atattgtttt ttcagcaatg tatagatgcg gcgggcaatc gccgcgtttt 2840221 cggtttgaac atcgagtacg agatggcggt ttgtaaatga taaagctcca ttcatccgaa 2840281 tgagtgcaga cagctcggca ttaatgcagc agtccttcac ttccagattc gttaattctt 2840341 tttttgtttc tgatgcaaat gacatatagc cacctcattt caaggcttca ttctttcagt 2840401 aaatcaacaa gaagagaggc cactttatgt gtatcgtgac gtattacgtc atttttatac 2840461 gttacaattt gatctctgat gacttcaagc cccatcgctt tcagctcttc gatatcaaaa 2840521 tcaacaggac gcgccgattc catttcgtac ttacgtttta tttcgtcggg aatgtcttca 2840581 ctgttcacta atatcgtatc aataaaacca cagcccatat gctgattgag cgctttcaca 2840641 tgatcagcag cggtgtaatg gagcgtttcg ccgggctgag tcatcacgtt gcaaatgtat 2840701 acttttttcg ccggcgcctt tatcacttct tccccgattt ttgggacgag caaattggga 2840761 agaatgctgg tatagaggct tcccgggccg ataataatca aatccgcttc cctgattacg 2840821 tctattgttt ccggcagcgg atcaatctgt tcaggcgtga gaaaaacacg cttaatgcgc 2840881 tgtccgtatt ctgggatcgt tgactcgcct gagaccacgc ggccatcttc catctcagca 2840941 tgcaaaacga cactggcatt ggcagccggc aaaacctttc ctcttacatt cagcaccttg 2841001 ctcatttctg tgacagcgtg aaaaaaatca ccggttatat ttgtcatcgc tgccaaaatc 2841061 aaattcccga gagaatggcc tgttaagtca ttccctttat tgaagcggtg ctgaaaaaga 2841121 tcttcaacaa gcggctccac atcggataaa gcggcaagca catttctgat gtctccggga 2841181 ggcggaattt tcagttcatt ccgcagacgg ccagagctcc ccccatcatc ggcaactgtt 2841241 acaatggccg tgatgtcaac gggtttatgc tttaggcccc gaagcaatac agaaagacct 2841301 gtaccgccgc caaagattgc gattttcggc ttttgtccca tcttatttcc ggcttctctt 2841361 ttcaatgtcc cggtgagtaa catgagtata gtaatccttt ttgaaataat cagctaaatt 2841421 ctcggctaat gtcacagagc ggtgctggcc ccctgtgcag ccgatcgcaa tgacaacctg 2841481 gctttttcct tctcttttgt aagatggaag cataaagctc agcagatcaa ttaatttctc 2841541 attgaacttt tgcgtttcat tccacttcat gacgtaagag gaaacctctt tatccttgcc 2841601 agtcagcggc cgcatgcttt cgatatagta cggattcggc aaaaatctga catcaaagac 2841661 gagatctgca tcaattggaa taccgtattt aaaaccaaat gacatcacat ttacggtaaa 2841721 tgtctctcct tggtttgtcg caaagtgctt cacgattttt tcacgcaaat cacgcggctt 2841781 catgtcagac gtatcgtaaa tgatttgaga gcggcctttt aattcctcaa gcagctctcg 2841841 ttctagcgcg atgccttcaa gcggcaggcc agtcgctgcc agcggatgcg agcgtctcgt 2841901 ttctttatat cttgtgacga gaatggaatc cttcgcgtcc aggaataaaa ttcgcggtgt 2841961 gatccacgga ttttcggcca tttcatccag cgcttcaatc agccggtcaa aaaattcgcg 2842021 gccgcgcaaa tccatcacga gcgcaacttt gctcattttc gaatttgatt ccttcatcag 2842081 ctctaaaaac ttcggaagca atgaaggcgg aagattatcg acgcagaaat agccgagatc 2842141 ttcaaagctt tggatcgcga cagttttccc cgctcccgac attccagtta taatgacaag 2842201 ctgaatatca tgtgattcac taacactcat ctttctcccc cctgacttgt ctttctattt 2842261 gatgtgctgc gggtctaaac gataactgag cagctcaaat tccggtgtat acgtaaatgt 2842321 gccgtgcagc agcccttgtc ccttcatcat aaaatcaagg atatggccgt ctccaggggc 2842381 cataggcagg ttctgaatgt cattgacatc gtgccactgc agtttgcctt cctctgattc 2842441 tgatacattt tgtcctgtat atgaatcagc gacaaacgta aacatcatcc actcggagac 2842501 aatgtggtca ccgtctttaa taataaaggt aaaaacgcct tttaattgag gatttatgat 2842561 atagatacca gtctcttctc tgtactctct gatgacggag tctctgactg attctccgct 2842621 ctccatcttg cctcccggcg cgacccacca tccgcgtctc ggcttttgaa gcagaagaac 2842681 tttgtcatcc gtctgaagca cacaatttgt cactctttgc aagtacgtca cctaaccttc 2842741 gtcctgtcat cgtctcttta ttataccgct tcaagatgcc tcccacaatg aagagacatt 2842801 gacaatcttt tcttctattt tacagcatat tcattcctta attcagatga ttttgctgta 2842861 actggaattc tcttttattt atggacaaaa aaaggacacg gataactgga gaatccgtgc 2842921 caaaaaagtg tattcattat aaaaaggggg tcaattactt tattaatcat aaccgaaaag 2842981 cattacacat gtgttacagc ggaattaaaa cccagtaacg taatgtgaaa ctcgtatgac 2843041 agcccttttt attttaaggt tttcagcgtt tcttggagct cttcgacata atgttgtacg 2843101 ctttgtgccg caatgcttcc gtctcctgta gccgttacga tttggcgcag tgatttttcg 2843161 cggatgtctc cggcagcgaa aatcccttca accttagttt ccatgcggtc gtttgtttcg 2843221 atatagcctt cttcattcgt aatgcccagg ttttcaaacg gtttagacag aggaagcatg 2843281 ccgatgtaaa tgaatacgcc gtctgttttg aattcacttt cttcaccggt taccgtatcg 2843341 acaagcgtta cgttaccgac tttgccgttt tcctcatgaa tttccttcac agttttgttc 2843401 cataggaagt caactttttc attatcaaat gctctcgctt gaagaatact ttgagcacgg 2843461 agtttatcac gtctgtgaac aatcgttact tttgaagcga aacgagtcag atatacgcct 2843521 tcttcaaccg cggaatctcc gccgccaaca acgacaagtt ctttgccttt aaagaaagcg 2843581 ccgtcacata ctgcacaata agatacaccg cgtccgccca attctttttc gccaggcacg 2843641 ccgatttttt tatattccgc acctgcagca atgatgacag cacgggcttt atattccttt 2843701 gaaccagctt tgactacttt gtactctttg ccgtcaatga cctctttaat atcgccataa 2843761 gcgtattcag cgccgaattt tttcgcgtgt tcaaacattt tgttagaaag ctcaggccca 2843821 aggatacttt cgaatccagg atagttttct acatcttccg tattggccat ttgtccgcca 2843881 ggaattcctc tttcaatcat taatgtcgat aaattcgctc ttgatgtgta tacagcggcc 2843941 gtcatcccag cagggcccgc gccgattata atcacgtcat aaattttttc ttctgacaca 2844001 ctattcactc cttaaaccat cttttcaagt ttgggctctt tcttataaga taagaatccc 2844061 catcaaacgt attccttacc catatcctat aaaatctcat ggtgatacgc tatttttttg 2844121 ctcaacacga ttaaatgtat tcgaaaaggg tatatgttaa taaagaaaga gccttctgtt 2844181 tatagaaggc ccttgtcata tttattattg aacaacacgt cttacaacac ctttaaatgc 2844241 tgctttccag taaggattgc tcatagagtc aacagatacg ccatgagatg tattgtcgtt 2844301 taggaaagta ccgtttccta agtagattcc tacgtgtcca tttgttttgt aagtgtcaaa 2844361 gaacacaagg tctccgcgtt tcatttcaga cgcgctgaca gcttgtcctc tgccaactaa 2844421 cgtatcagtt gttgttccgc ctacaggtcc aaggttaaca cctgcagaag cgtatgccca 2844481 gcgtacgaat gatgagcagt caaaaatacg gttgttgata tcagactgag tgcgtccgcc 2844541 gccaaacttg tacggagatt gtcctacaat gcttgaacca acgctgatcg cgccttcaat 2844601 tccgccagag ttgctgataa cagtgccgcc tgaattgctg tttgagccgc tgctcttctt 2844661 agaagatgag ccgtttgacg aactgtttga tgaaccgtta gaagaattgt ctgaagaatt 2844721 gtctgaagaa tcatcagatg agcttgcttt tgatgattca gttgtcgccg tttgactgtc 2844781 atctgtttgt gtttcatcag atgctttttg tgcttcttcc tgctttttga tcaaagcagc 2844841 cgctgcttct tgttcttttt tgatgcgtgc ttgttcagct tcagtatttg ctttttgatt 2844901 tgcaagttca gacgcctctg attttaattc agaaatcgct ttagccgttt tcttttggct 2844961 tgcttttgct tcgtcgaaaa gcttgtcttt ttcattaagc tgtttatcaa ggtctttttg 2845021 cattgtttct aatttagcca aggcagcttg aacttctttc agcttgtcat tcaaatccgc 2845081 ttcagaatct tcgagcttcg ctttatcctg ctcttgctgt ttgattaaat ctttgtctgc 2845141 gtccacaata gatgaaaccg cagtcgcacg agagataaag tcaccaaagc ttgttgatcc 2845201 taaaagaaca tctatgtatc cttgagatcc gccgctttcc tgtaaagaac gaacgcgttt 2845261 tttcaggatt tcattgcgtt tttcgatgcg tgcttcagtt tctttaatct cttttttcag 2845321 ttttttgatt tcttcttttg ttttatcgtt ttcttctttt ttatcttcaa tcttgttgct 2845381 tgtatcaagc gccttatcgt taatgtcttt cagttctttt tcaatctttg attgattttc 2845441 ctgaagctcg gttaattctt tttccttcgc ttcaatgctg gaagcaacct cagattgctt 2845501 gctttcgatt ttttgtttct tttcatctaa tgtttccgcc gatgcagttt tacttgtaaa 2845561 tgggatcaaa aaactgcttg tcccgatgac ggaagccaaa ccaagtgtaa ttaaactctt 2845621 tctcactttt tatatcctcc cttttactgt gaacctgtcc tcatttggaa tcgtattttg 2845681 aacatcaagt ttcgttcctc atactctacg aggaatgatg gttgtttatg gttaattatt 2845741 ctgtgcatct cttattctgg ttgtatagcg tttatttcac atcatatgta aaaaacacta 2845801 attccttatg tacgagaatc attataccat caagtttcga caaattagcg ataaatttta 2845861 ttacatttat gtttcaaaca gatgtcaagt cacacatcat ttgtcatttt tcttaagcgt 2845921 gtaaaaaaac tgtcgatatt attttcttaa tataatctat ctaacaaaaa aagagtcgat 2845981 taaataaatc aactctttaa aatttactat tctagaatat catcaatata tttcatatat 2846041 ttcgtcaaag ttgccggaga gatgccgaat cgggccgctg tgtctttttt cgtgtcttgc 2846101 ttgccatggg cttctttcca aatataacag atggctgctg cccagccttt ctcattcttc 2846161 aacggagcag ctgcacgaat ttgctggatg acatgaaaaa cccagcagct catgacttct 2846221 gttttcatct cttctttttc agcttgctct aatagtttga ccgtttgata agcgaaaagt 2846281 gcatcctctg aaacgtcagc agccgcagaa tctccattca gaagcagctt tacaaaatga 2846341 gtttcaaaag gagcggtaat tctctttgag cgtatcaccg cttcaagatg ctctgtttct 2846401 ccctttgtgc tgctgatata ataggctgcg agtcgctgct ccacagatga aggaagagct 2846461 tccctccgct caatccaagg cgccgggcgg tcttcgccgg gatattgcga ctcgactttt 2846521 ctccagatcg tctcggcaaa gtcggtatgt cccgtaaaat aagcagagca ggaaagccag 2846581 taaaagaagg tgtcgtcacc ctcaaagccg gttttatata atgatttgag ccatttatat 2846641 ccgatctcgt agcggccgac aagcgccaaa gtagcaccca atttataacg ctgctccaat 2846701 agcatcggat agacattgga gagctgatca ctcaattccg ccactttttc gtcttctctt 2846761 tcataatagt agaaaacgag aagattgcat aaggcgtgaa gatttccttc attatgagaa 2846821 agcacttcat aagcggtttg cttcgctttt acaacgtttc ctgaatagaa ataggcaagc 2846881 gcgagattgt tgtatgctga ccaaagctcc ggatattcag ttgtgatttc ctcaagcgcc 2846941 gcaaccgctt cagcaagctg gccgctttcc agcaatgact ttgcccgatc ctgtttcacc 2847001 agcagttcat cctgatcata caacgaatcc tcaatgccgt cgtctcctaa atcgagcaaa 2847061 tcaagcagac tatcgttttc ttcggcgaat tcaccatccg ggtccgcatc agaataagcg 2847121 gccgcttctt tataagcttc ctggaagagc cccagatggg caaagttatt cgctttaaag 2847181 taatggcact ccggcatttc ggcctccaga tttgccatga tatagtcaag aagatcgttc 2847241 gactcttgat actggcccat ttccgaataa atgaccgcaa gctgtgaaag catctctgaa 2847301 tcctccggct ccaaatgaac cgcgcgctga atcagtttgc ttgcccgttt tagattgcgc 2847361 tctttatacg ctttcaagcc tttatgaaaa aaatattgtc catcttgaag cagctggaca 2847421 atttgtgcgt gatttttatg ttcagaagtg tgttttccca caactaccct ccgttttata 2847481 caatattacc gtcagtagta taccataaat cgtaagcccc tcaatagttc aaaaggaagg 2847541 attgggaaaa tccctcctct tttttattgg ctgattcgac caaaatttac ccggctttgt 2847601 tttctaagtc cgcattcatt ttcagctgct gttcagcaaa atcccggtaa aggccatggg 2847661 aagccattaa ctcatggtgt gttccacgac cggtaatttc ccctttttca acaaacaaaa 2847721 gctggtccgc atctacaacg gtagataggc ggtgagcgat aacaatcgtt gtgcggccct 2847781 ccatcagcac ctccagcgcc tgctgaactg atttttcaga ttggctgtcg agacttgagg 2847841 tagcttcatc gagcataaga atgcttgggt tacggagaag cgctctcgca atcgcgattc 2847901 tttgcctttg tccgcctgac agcataatgc cgcgttcgcc cacttctgta tcaaactgat 2847961 tcggcagctc ctttataaaa ttgagcgcat atgccatctc cgcggctttt tcgatctcag 2848021 catccgtcac atctcgttct aacccgtagc aaatattttc tctgattgtc ccggacatta 2848081 acgggctttc ctgtgataca tacccgatat gctccctcca cgattcaagc gagtaagtat 2848141 cgaccggctc gtcccccagc cgaatggtcc ctgcagtcgg agaataaaag cgttcaagca 2848201 gcttaaacag cgtcgttttt cccccgccgc tcggaccgac gatcgctgtc actttccctg 2848261 cttcaatgac ggcgctgacc tcttttaaga tcagctgatc aggcttatat ccaaaagaca 2848321 cgcgatcaag ctggataggc agatgtgcat tttcaatttg ttttcctgtc actgtatctt 2848381 cctcttcctc tgccaaaatc tcaatcattc gttctgttgc accgattgat ttttgcagct 2848441 gtgtgaaaaa cgttgtaatc tggcccatcg gcataataat ttgaaacaaa tataaaataa 2848501 aagccacgag cgctccggct gtgagctcgc ctgatgagac ctgcatgccg ccatatccga 2848561 tcactgcgac aagcgctgcc attaacacga gtgaaataag cgggccgaca agcgattgaa 2848621 ccttggcttc acgaacgcca agcttaaata atgaggaaat ccccatcttc ccgcgcccat 2848681 attcgacatc ctccgcattt gaagccttaa caagtctgat ttccgggaga atttgattaa 2848741 gcaggcctgt aaaacgagcc gtttcatctt gcgtttcccg tgaaatggag aacattttcc 2848801 gtccaatcgg caccaaaata agagcggcca gcggaacgac cactaacaca agcagtgtca 2848861 gcttccagtt cataataaac aagattgtca atgatccaat gacagaaatg atgcctgtaa 2848921 taaatccgct gatatgggtt gtaatcaatt ctttgaccac catcgtatcg ttcgttacac 2848981 ggctgactgt ttctccggaa gcatttgtat cgaaataaga gacaggcagc ttaattaatt 2849041 tcttccataa taactcccgc agcccggaaa tgattttttg tccattatag ttaagcgcat 2849101 aggtggcata agcgcttaaa cccgcctgaa cgaaaaacac cagcgcgatc aaaccgattt 2849161 gcgtgcctga cagatttgac atagaaaaac catcgacaag ctgcttcgtt aataatggaa 2849221 tgagcaggct gaccagcgtg gttactacac tgagggcaag cgcaaaggcg agctttccat 2849281 aagaaggatt ggtccgtctt actaaggcaa aaaagggttt caatttactt ttagattttt 2849341 gtttcttggt tggcatatat tttcctcctg tttcagcgtt cagaaaggtg aaaagtcata 2849401 gcaaaaggat gatttttact ctttctcaat catatcaatg gagaaagact ttttcagtat 2849461 atttttgccg tgatcaaaat aaaaatctcc cactcattgt ttgaatagga gatttttgtg 2849521 ttagacatct ttcactggct tcttttttct gtaagtcaat gttacatcct gctgtcgcag 2849581 gtcttctatt atcattttgt accgatcaac ttttgcggta tgttcttctt ttatcatctg 2849641 aagggcagct tttcgttttt cgctattaga ctcaagctct ttttttattt tttttacaat 2849701 caaccctttt tgccctttga tttcctcttt taatgaagac tcaaatttct ttgtcaggct 2849761 gagaaagtcg ttgatcggtt gattgagggt gcccgctttc cccttcattt catcttgggt 2849821 aagaaacata taggtcgttg atacaatttc tgtttcactt tctgaaaata aggaagtcac 2849881 tcttcatatt cctcctaaga ctgaaaatca aataactgag aaatcatttc ttctttttca 2849941 aacagctttt caatactctc gcggatattt ttgataaaat ctcttttttc tgttgtctgt 2850001 ttttttaatt cagcaacaat tccatcattt gcaggaagcg cacctgtgtg gaatgattca 2850061 tgaactgaga ttttctccaa tttatcgaat gtgtggctga aaccagctgc aagccggaat 2850121 tgaagatcga aggcataatg cgaagggttt tcttccatat gatgaatagc cgtgatgatc 2850181 gcctgctttt tgtctatgaa gtcttcatcg atttcctgac tgtaaacctt ctggtactta 2850241 gaaatcgcat cttccatatc ttcaacgatt ttcataccgt tttgatagat tctgacagcg 2850301 gatgagagat tgacttgaat cgtttctccc gagccactct tccctgtaaa ataaatatcg 2850361 gagcctttat agctgaagcc tttttccttt gacaaggcgt tgagcatttg aacgatgctg 2850421 tggccgtcga cgataagttt tagtgcgtct tttgtttctg tgtcgagtgt tttcaatgag 2850481 gacagaattg attttacata gtccactatt tcaccaacgt cttttaaagc ttgcataaat 2850541 tggccatgtt ttagatggtc tatgaaatgt tcgtaccgtg actctatgcc tcgcatactc 2850601 gcattaatat tcgttaattc ttttttgatg actttctttt gcgtttcatc aatataacca 2850661 ttttcagcta actgatctac gaccggtccg ctgtttctca acaaggtatg aagaaaacct 2850721 aaaaacgacg gcagttcctc ttttattcgg ccatacattt gcttaacatc atcaaaatgc 2850781 tcatatagga cacttacttt ctttaaagcg ccgtctgtgt ttttcacttt ttcaatcagg 2850841 tctatgtcta tcccgctggc tgcctttata aaaccgttca agccgtcttt ttcatagtca 2850901 tccttatatt tttgaaggaa tttttgaatt gacctcacat cttcgtcagg aaccccatcc 2850961 ataatgtttc ggatgccttt tacacttgta tttgtatctg ccatcttcac atcaccgaat 2851021 gtaataaaat cggccttgcc gctgactcca tacagcgggt catcttttga gatgcgctga 2851081 gtgatgtttg ttgttacgcc tttgtcttca taatattttt ggatttcttt ttttaacttt 2851141 tctggcggga tggaatctat atcttcatat ttataactaa atttcctaat aacatatcta 2851201 tataaacttt catcagtttc aagtaattga tcaatattga cttgagctcc atttacccca 2851261 taaacttcat catattctcc atcaatcaat tgcaccataa cttggttatt atttgcaagt 2851321 gaatgtccta aggcgaatgt ttttaaatcc tcagagttac ctgctgcttt ctttgctttg 2851381 ttagtaaact cctttgtagc ctcatactga ctatgatcaa ttcctaaaaa aagaccaaaa 2851441 aagttatatg accaatcctt attatcggca ctaccttctg aaataatctg aagctgatca 2851501 atatgttttt tctcatctat tatatggatt gccgttccat cgtaacctga ttctctggtc 2851561 gaactttgta tacttgtatt ctgatttaca agttcattgg aggtgtaaat ttcaattttc 2851621 atattctcag gaagatcgtg gtgggtttcc tctttataaa ttctgcgtat atctgcttcg 2851681 aaatccttct tagctttctt aacttcactc gcaatagttg aggcaaactt ttgtttatag 2851741 tcatattcta aatcaattaa ccttaacttt acgttctcat tctcaaatac atttttattt 2851801 cccatcttat ttctcctttt tatctattaa aaaggtgata gaattaatta atttctcaac 2851861 tttattttta gccttttctt catctaagga gcatggttga ttttcatttt tgcatccaag 2851921 ggtaaaggcg tattctactc ctaggttatc ttcctctgta gacttaacat atccaaaata 2851981 actgtatgaa taattatatt ttctatcaat atcgtcaaag atgtcttttt tcttggcagt 2852041 gtaaatatcc gttttctttt tgctgctttt tttgtattcg cctttataat cattttttcc 2852101 actaacaata tctagcattg tcttaggttc attcgcaaaa ctttcttctt tgtaatatgt 2852161 tacatggcca tcaaacatta cattggtgtc tttatcataa ctattaaatc caatactttc 2852221 tttgtttttc ccggttaacg atgatcttct tgatagatac tttccatcct ccggaaacaa 2852281 catcctaaac cctttcagct tagattccag caaataatat cctggttcct cttcttttgt 2852341 tgacaccatg tactctctcg ttttctcgtc ctgaaacgca ggtacttgag gcagatcctt 2852401 gggatccccg ctagcttttt atttttaaaa aattgtcaca gtcatgtgcc aaagtcctct 2852461 ttactttcaa ttgtataggg actgtaagcg ttttaacata gagtcaaagg gaagcatcat 2852521 tctctgaaca tatttcttaa gtgcagaaaa aggatggagg ccataatatg agtcagaaaa 2852581 cagacgcacc tttagaatcg tatgaagtga acggcgcaac aattgccgtg ctgccagaag 2852641 aaatagacgg caaaatctgt tccaaaatta ttgaaaaaga ttgcgtgttt tatgtaaaca 2852701 tgaagccgct gcaaattgtc gacagaagct gccgattttt tggatcaagc tatgcgggaa 2852761 gaaaagcagg aacttatgaa gtgacaaaaa tttcacacaa gccgccgatc atggtggacc 2852821 cttcgaacca aatcttttta ttccctacac tttcttcgac aagaccccaa tgcggctgga 2852881 tttcccatgt gcatgtaaaa gaattcaaag cgactgaatt cgacgatacg gaagtgacgt 2852941 tttccaatgg gaaaacgatg gagctgccga tctcttataa ttcgttcgag aaccaggtat 2853001 accgaacagc gtggctcaga accaaattcc aagacagaat cgaccaccgc gtgccgaaaa 2853061 gacaggaatt tatgctgtac ccgaaagaag agcggacgaa gatgatttat gattttattt 2853121 tgcgtgagct cggggaacgg tattagaaaa ataggtgtat ttggaagaga acgaaagcaa 2853181 ggaggagcag acgtttgaac cgatcaggca agcatcttat cagcagcatt atcctgtatc 2853241 cccggcccag cggagaatgt atatcctcaa tcagcttgga caagcaaaca caagctacaa 2853301 cgtccccgct gtacttctgc tggagggaga agtagataaa gaccggcttg aaaacgcgat 2853361 tcagcaatta atcaaccggc acgaaatcct ccggggatcc ccgggtacca tgggcccgcg 2853421 gccgcctcga gaattcatcg atacgtagcc ggctagcacc caatataaat ctaaatacct 2853481 attacttttt tcacaaaaca aaaagagccg tatcatccgg ctctttactc ttcaatctca 2853541 gaatggcgtt ttttcaatac gtcaagcaca tcatccagcg gcagggattg ttctctgagc 2853601 aggacaagca ggtgatacag caggtctgcc gcttcccatt tgagttcctc atgatcccgg 2853661 tttttcgcgg cgatgatgac ttcggatgct tcttctccga cttttttcaa aatcttatcg 2853721 acgccttcac ggaagaggta cgtggtgtaa gctccttcag gcatttccgc ttggcgttcc 2853781 gcgatcaccc gctccagttc gttcatgatg ccgaatcggt ccgcggcctg ttcttctgtt 2853841 tgttcctttg taaaacagct gtagctgcca gtgtggcatg ccgggcctga cggttctacg 2853901 agtacgagca gcgcgtcttg atcgcagtca taccggatac ctttgacggc ttgcgtgttc 2853961 cctgaggttt ctcctttatg ccataacgct tggcgtgagc ggctgtaaaa ccatgtttcc 2854021 ttcgtttcca gcgttttttc gtacgattcc ttgttcatat acgcaagtgt cagcacttct 2854081 ttgcttgccg catcctgcac gatagcagga attaatccgt cctcgttaaa acgcagttca 2854141 tctgcctgtt tcatctcaca ttcaccccgt actctttcaa gtatgatttc acttctttaa 2854201 tcgatgtttc tttataatga aaaattgagg cggccagcgc ggcgtcggct tctccttttg 2854261 taaaagcctc aagcatatgc tgtgcgtttc ccgcgcctcc cgaagcgata acagggacgg 2854321 ggacagcttc ggaaacaagc tttgtcagcg tgtggtcgaa accttttttc tcaccgtcgg 2854381 agtccatgct tgtcagcaat atttctcctg ccccgcgttt gacgccttct tttgcccacg 2854441 cggtgacctc ccaatctgtt ttctttctgc cgccgtgcgt gtagacctta tatgtgtcag 2854501 attctttgtc atacttggca tcaatggcaa gtacgatgca ttgagaaccg aaaaactcgg 2854561 ctccttctgt aatcagctca gggcggagaa cagctgccgt gttcaccgac actttgtccg 2854621 ctccggcacg cagtatcgtt ttcatatcgc tgagctgatt gatgccgccg ccgactgtaa 2854681 acggaatggc aagcttcgcg gcaacctgct ccacaacgtc aaccatcgtc tttcgtcctt 2854741 cgtgcgaggc ggagatatca agaaaaacaa gttcatccgc accttcccgg tcgtacactt 2854801 cggcgagttc aactgggtca ccggcatcct tcaattcgag aaattgaatt cctttgacaa 2854861 cgcgtccttc tttgacatca aggcatggga taatccgttt tgtgatcatt tgcgcttcac 2854921 cctttcaagc gcctcactca gcgtaaactg attggtatac agcgcttttc cgatgatcgc 2854981 tccagagacg ccgtccgcct cattgcgggc gagagcttcg agatccgcga cggagctgac 2855041 tccgccggaa gcgatcaccg atttccccgt ttccttagca agctcgaccg tgcttttaac 2855101 attggggcct gacagcattc catctgtcgc gatgtcagta aaaataaaga cttccgcacc 2855161 ttcattggct agctctttgc ccagttcagt tgccttaagg gttgatgttt caagccatcc 2855221 ctctgttgaa acaaaaccgt ttctcgcatc cagtccgatt gcaattttct cgccatattg 2855281 tttcagcatt tttttgacaa acggagggtt agaaactgct gagcttccca ggatcacccg 2855341 ctcgactcct gctgataaat attcatagac gtcattttca gaacggatcc caccgccgat 2855401 ttcgactttc aggttcagct tttgcgcaat ctcaatcaca tggcggtcat tcactctttt 2855461 cccttctttg gccccgtcga gatcaacgag atggatccat tcggcaccct ctttctcaaa 2855521 taactcagcc atgtcgtacg gtgaatcgcc atatatcgtt tccttattat aatccccttg 2855581 aacaaggcga acacatttgc cgtttctcat atcaattgcc ggatataatg taaaagcact 2855641 cattttttca ccttctgttc tgctgccatt ttcgtaaatt gggttaaaat agacattccg 2855701 accgtgctgc ttttttccgg atgaaattgg gcgccgaaga cgtttctttt tccgactaca 2855761 gcaggcactc gtacaccata atcggcgctt gccagaagcg cgttctcctc catcccgtca 2855821 atgtaatagg aatgaacgaa gtaagcgtag ccttgttctg ttttagtcag cagcggagat 2855881 tcattatgaa aagaaagacg attccagccc atatgcggaa ccttcagctt gtttcctttt 2855941 tcatcttctg ctttcagcct gactgctttt ccttttaaca gcccgagtcc tgaagcggtg 2856001 ccgttttctt cgctttcttc aaataaaagc tgcatgccga ggcagatccc gagaagcagc 2856061 cttccctctg agaccatatc gtgaatcaat tgatcaagct tcgtgtagcc caaattgtcc 2856121 atcgcgtctc caaatgaacc gactcccggc aaaatgaaag catcagcttc tttcagctcc 2856181 tccggctttt cagaaacaaa atacggcacg ccgacacgtt caagcgcctt tgagacactg 2856241 tataaattcc ccattccgta atctatcacg ccgatcattt acagcatccc tttcgttgac 2856301 ggtattcctt taactcgcgg atcgatcgtt gtcgcttcat caagcgcacg tcccagtgct 2856361 ttaaaaacgg cttcaatcat gtggtgggta tttgttccat aatgaacgat gacgtgcagg 2856421 ttcattcgag cttcgagcgc cagcttccac aaaaattcat gtacaagctc cgtatcgaaa 2856481 gttccgactt tagcagccgg gaaatcagcg cgcatttcta agtgcggccg gttgcttaaa 2856541 tcaatcacaa cttgagcaag tgcctcatcc atcggcacaa acgccgatcc gtagcgtttg 2856601 attccttttt tatcgcccaa cgcttcgagc agcgcctgcc ctaagcagat gccgatatct 2856661 tcagtcgtgt ggtgatcatc tatatcaaca tcgccttttg cgttaatgga aagatcaaat 2856721 tggccgtgtt tcgtgaataa atccaacata tgtgtcataa acggcacatc tgttttaata 2856781 tccgcttgtc ctccgccgtc tattgtaaat gccagctcaa tatctgtttc gtttgttttc 2856841 ctgacgcgtt ccgcttttct catttagaaa tcctccgttc tctcgcttca attgatctgg 2856901 catgggcttc taacccttcc agtctggcaa aagccgcgat gctttcggca tgttcttcaa 2856961 aggctgattg actgtaagaa ataatgctcg atttcttttg aaaatcagtt acgtttaatg 2857021 gacttgaaaa tctggctgtt ccgtttgtcg gaagcacatg gttcggtccg gcaaaataat 2857081 caccgacagg ctcagggctg tatctgccta agaaaattgc acccgcatgt ttgatactgc 2857141 caagcaaagc ttccggagac tgtgttatga tttctaaatg ctctggcgcg agtgtattga 2857201 cagtctcaat cgcttctacc attgtttccg ccacatatat acaaccgtaa tctctcactg 2857261 aagcttccgc tatttctctt cgcggcaagg tttccagctg cttattcacc tcggctgaaa 2857321 ccgtctcggc cagcgccatg gaatctgtga caaacacaca tgagctaagc ttatcgtgtt 2857381 ccgcctgtga cagcagatcg gctgcaattt cgctcggaat cgctgtttca tcagccagca 2857441 cgacgatttc actcggtccg gcaatcatat cgatatcgac atcgccgaac acttctcgtt 2857501 tggcaagcgc gacataaatg ttgcccggac ccgtgatttt atccaccggc tcaatggttt 2857561 ctgttccgta tgctaacgcc gcaatcgcct gagcgccgcc cattttgtaa atgtctttta 2857621 tgcccagctc ggctgcagca accaaaactc caggagacag cagaccgtct tttcccggag 2857681 gcgtgacgag aacgattctt tcaacgcccg ctacgagcgc cggaatcaca ttcatcaaaa 2857741 cagatgaagg atatgcggcc gttccccccg gcacatatac accggcggaa tccagcgccg 2857801 tcactttctg ccccagcatt gtgccgtcct ttctgtgata aaaccaggag gattgcagct 2857861 gtctttcgtg atattcccta atattttcga ttgcctgcct aatcacctga agaagacgtg 2857921 aatccagtga ggtgtatgcc tcctcaaatt cttcttttgt gaccagcggg ctgtctattt 2857981 cgatgcagtc aaatttcgcc gtgtagctgc gaaccgcctg atcaccgttt gctttaacat 2858041 cttcaataat ggaccggacc gtctttcttt gctcttccgt tccggcatcg atggaacgct 2858101 tgagagaaag ccgttccgct ccgctgatgg ttttgatctt cattttgccg tctctccttc 2858161 cacaacgaga gataggcggg atgccatttc gtcaatcaca tcgtctttca tgcgatagct 2858221 taccgggttg acaataaagc gagaggtaat gtcacaaatg tgctccgttt caacaagccc 2858281 attttctttc agcgtctgtc ctgtggaaac aatgtccact atccgatctg caagcccaat 2858341 gagcggagcc agttcaattg aaccgttgag cttaataatc tcgacttgtt ctccctgctc 2858401 tctgaaataa ctggaagcca cattcggata ctttgtcgcg attcttggcg ctactccgct 2858461 ccagtctgta ttcggaagtc cggcgacagc taagtggcat ttgctgatgt ttaaatccag 2858521 tacctcatac acatcgcgtt cctcctccag catgacatcc ttgcccgcaa ttccgacgtc 2858581 tgccacgcca tgctccacat acgtggttac gtccatcggc ttcgctaata taaaccgaag 2858641 attttcctcc ggcacatcga tgatcagttt tctcgaatct tcaaactcct cagggagcct 2858701 gtagcctgcc tgcctcagca gccctgccgc ttcttcaaat atccggccct ttggcatcgc 2858761 cattgtgagt aacttaccca ttttgctctt cctttctggc accgataaaa taagtgacgt 2858821 ttgcaaaaga ttttgtcatc tggtcgatat tttctattcc cgataaatct tgaagaacca 2858881 ctttgttccc tttcatgcgt tcttcattcg cataagcgat ggcttgcgcc cgctgctctt 2858941 tgctgaaaat aacagcgtct atttcacaag gttcgtcctt catatgaagg gcttcaatca 2859001 gccggtcgat ccgaagcccg aagcctgttg ccggtgcagg tgaatcaaaa tggcccagca 2859061 gcttgttgta acggccgccg cttccaatga caaaaccgac attctcggcg tacacttcaa 2859121 ataaaatccc tgtgtaatag ctcatgtggc tgaccatatt cagatccagg cggacatttt 2859181 ccgtacatcc gtaatcctca agaatgtccc acagcgcctt cagctcatca accacgcttt 2859241 ttccttgcgc agaatcgacg atttcctcgg cacgtccgca tacttctata ccgccccgca 2859301 gttcaaggag ctcaagcagc ctgcttttat caatggagga aagcgggaga gacttgacat 2859361 gctctctgta gccgacgtag ttcttttcat ataagaacct ccgcagcaca tcagctcgtt 2859421 caacgtttcc gagcacctca acaaacaaag catccgcaat gccggcatgg ccaattgcaa 2859481 ttttaaagga tgccagccca gcgtttttta atgccccgac gactaaagca atgacctccg 2859541 catccgcgct cgtcgtgccg tcaccgatta actccactcc gacctgctcg aactcagccg 2859601 gacgtccgcc ttcacgctcc tgagccctga atacatttgc cgcatagccg actcttagcg 2859661 gatgaccgtg tttcagaagc ttcgatgccg ccacccttgc aatcggcccc gtcatatccg 2859721 ggcgaagcac caatgtcttg ccgtcctgat caagtagctt aaacagctgc tgctcttcaa 2859781 ttgctgactg gacgccaacg gtatcgtaaa actccagtgt cggcgtttcc ataaattgat 2859841 atccccattt atcaatcaaa tcggttaacg atcgtctcac cttttttttc gtttcgtata 2859901 aaccgggcag tgtatctctc atgccgtgcg gtttttcaaa cataaacatc aacccgagca 2859961 cctccgctgt tatcttatga aggaaaattc cgaatccttt agttcgctaa tatgataata 2860021 tgttagcaga tgaaagaatg aaaatcaacg cttaacttca gtaaggatat ttttagttca 2860081 aatatccttc tcctcattat gaaaaaatca tgaataatgt attaaaggta cgtaatatct 2860141 caaattcttt atgtttggca tgctataata caaatcaaat agagaacaag gagataaaga 2860201 tgaaaacact gcgaactcta tgtgtcctga tgattctttc aggcgttatt tttttcggac 2860261 ttaaaataga tgcaaaagat atagatattc cttttttgaa cagccttaaa aaagtggttt 2860321 ctgatagcga tacagactca gctgcgaata gcaaaaagga gctgaaggga agcgcaaaac 2860381 cgctggatgt catcctttac aatcaaatgg acgcaccccg gctctataac ggctgtgaag 2860441 taacaagcct tgcgatggtg ctgaattatg cgggatacga cgtgacaaaa aataccctgg 2860501 caaatcaggt tgccacagtg cctttgacat acagcagcgg attaaagggt gatccgaatg 2860561 acggatttgt cggggatatg gcgaatggcc ctggtctcgg tgtctaccat cgaccgatct 2860621 atcagctggc gaaaacctat gcgggagaca aagtgtctga tctgactgga aaaagtattt 2860681 ccgctgttta tcagcagctt gaaaaaggca atccagtttg ggttattacg acagccaact 2860741 ttacgccagt tgacaacatg cagacatgga aaacgccaaa cggaacgata gaaattacgt 2860801 acagcgaaca cagcgtcgcc gttacgggat atgatgataa atatgtgtat ctcaatgatc 2860861 cgtatggcta taaaaacaga aaaaccgata gaacaagctt tgaaaaagcg tggaaacaaa 2860921 tgggcagcca ggccgtggtt attcaaaagt aaacacctga agcctcacta tgctctattc 2860981 tgagcaaata cgacaatatt catgcttttt gtatcaatcg gtaagatcga ttcattttcc 2861041 atttttcacc caaaattgtc tttactttca ggctgtctgt ttttatgatt aaagcagatt 2861101 cagccttgcc ccgatctatg cgagagaagc cggtgcaagt cgctgacgct tctcttgcaa 2861161 aaaatgaaag atatccgggg aggatttatc attgaaaaaa atcgtgtcta tcctatttat 2861221 gttcggtttg gttatgggtt tcagccagtt tcagccatca accgtttttg cagctgacaa 2861281 agtggtgcac gaaacaatta tcgtaccaaa aaatacaaca tatgacggga aaggacagcg 2861341 gtttgtggca gggaaagaat taggtgacgg aagccagtca gaaaaccaag accctgtttt 2861401 tcgtgtggag gatggagcaa ccctgaaaaa tgtggtgctt ggtgcacctg cagctgatgg 2861461 cgtgcacact tatggaaacg ttaacattca gaatgtgaaa tgggaagatg ttggtgagga 2861521 tgcgttaacg gtgaagaagg aaggaaaagt gacgatcgac ggcggttctg ctcaaaaagc 2861581 gtcagataag atattccaaa tcaataaagc cagtaccttc acagtgaaaa atttcacggc 2861641 ggataatggc gggaagttca ttagacagct tggtggttca accttccacg ttgatgtgat 2861701 catcgacaag tgcaccatca caaacatgaa ggaagcgata ttccggacgg acagcaaaac 2861761 aagcacggtc agaatgacaa atacacgcta ctctaatgtc ggtcaaaaat ggattggtgt 2861821 tcagcatatt tacgaaaaca acaacactca attttaacaa aaaaagtccg ctgatgttat 2861881 tcagcggact ttttcaatct ttcttgcatt tcttccttcg tatagatgat cctcatcgga 2861941 tttccgccga caaatgcccc gtcaggcaca tccttatgga caagcgttcc ggcggacaca 2862001 actgcgccat ctcctatttt caccccgggc agaatggtcg tgttggcacc aatcatcact 2862061 tcgtccccga tcagaacttt gccgatccgg tattcgtgaa tcaaatactc atgggccaga 2862121 atggtcgtat tgtacccgat gattgtattt gttccgactg agatcttttc cggaaacatg 2862181 atatctggca tcaccatgag ggcaaaggat gtctgttttc caaccttcat ccgcagaaat 2862241 gtgcggtaca gccagttttt catccctata aacggcgtat atctcgcaat ttgaatgaca 2862301 atgaaatttt tgacgacctt taaaaaaggt accgtttgat agacatgcca cagtgagttg 2862361 gcccccgaga ccggatgacg atctgttttt ctcacagatt acttcactcc aacgatttgt 2862421 aatagatcac tcattttctc aagcataaaa tccggctcat gcttcgccag catttccggc 2862481 cctttaatcg tccatgcgac tcctgccgtt tttgtaccgg cgtttttccc tgccagcaca 2862541 tcatggtaat tatcaccgac cataatggct tccgccggct cgcttcctag ctgtttcagc 2862601 gctaacagca caggctcggg atcaggcttt gcattcgtca catcatcaag ggtgacaact 2862661 gtttcaaaga attcgccgat tcccgtgagc ttgaggccca tattgacagt atctcttaat 2862721 tttgttgtca caattcctaa tgtaaagccg gcttttttta atgcatccag ggtctcatat 2862781 accgtttcat attcagtgac gagtgaatca tgcatgtcat gattgtacgc tctgtacata 2862841 gcgatcatat cctcgcattt atcagggtcc atcgaagaga acgtatcaaa aagagacggc 2862901 ccgataaatg caaggacatc ttctcgttta tacttgctcg gataataatg ctccagtgta 2862961 tgcaaaaagg acgcgataat taattcattc gtattaataa gcgttccgtc taaatcaaac 2863021 agaatcgtcg ttacttgttt gtcactcata ttgcttcctt tccaaccgct gagggtttcc 2863081 attttttcca cgtgtgcgca atagccattg tcagcagaac tgctgtggtg acacgaatca 2863141 aaagaagcgg ccagaccggt atgccaagcg gaataaagac aagtgtatct tccacgaccg 2863201 cgtggcaggc aacgagaaat ataaatgcca atgtcatgtc ccgcttgctc acgccgtcat 2863261 cctcgacagc tttgatcatg acacccgctc cgtaggccag accaatcgtc agtcccgtca 2863321 ccatcgtcat agacgtattt ttattcatgc caagcagctg cgtaaacggc gacagccacc 2863381 tggaaaaccg ataaagccag cctaaatctc ttaaaaactg gatgataatc atcagcggga 2863441 tcactattgc cgccagctgc aaaacaccaa gtccggcttt cgttaatgct tctgccaaca 2863501 ttcctagcca gctgtctggc gccgcgctct tcgcagcgat aaaaccgtac tgcgccgttt 2863561 cctttccgcc atgccaaatg aggttgatga cgatggctga cacagcggcc aaaccgatgc 2863621 gcacggccaa tatgacgcca attctgatac caacctttgc ggcaactgtc gattcgataa 2863681 tcaagttatg acagaaagaa agcataacag ctaaaataaa gacttctttc acagataaat 2863741 ccaatgttaa aatcccggca attcccgcat acagattcag catatttccc agtacaagcg 2863801 gaatggccgc ttcaccagaa agcccgaaga gacccattac cggtgtgatc agccgtacaa 2863861 gccaatccat gacaggggta tgctggagca aagtgaccaa tagcgttacc gggaaaatca 2863921 ctttacccag cgtccatgtt gtttgaaaac ctgctgcaag accggccaga aagatcttct 2863981 tcatccctca tccccctttg ttgacgtcta ctccgcgtac cgctccttcg agtatccctt 2864041 gacgcgtctg aagatgatgg ctgccacagc caaaacaatc aatacgattg aaatcacctg 2864101 agcgatgcga agtgaatcag tcagcattaa gctgtcagtc cgcattcctt caataaagta 2864161 tcttccgatt gaataccaaa tgatatagat caagaacatc tcgcctctac gcaaattcgc 2864221 tctgcgcagc agcagtaaaa caatgacgcc gacaaagctc catagtgatt catataaaaa 2864281 agtaggatga taatattgcc cattgatata catttgattg atgataaatt caggcaggtg 2864341 caggttttct aaaaaggctc tgctgacagc ctcgccgtgc gcttcctgat tcatgaagtt 2864401 cccccagcgg ccgatcgcct ggccgagcaa aatgctgggc gcggcaatat ccgcaagctt 2864461 ccagaacgaa aggtttttca ctctcgaaaa cacataaccc gttaaaatgg cgccgattaa 2864521 tccgccatga atggcaatgc cgcccttcca aatcttaatg atttctcccg gatgtgccgc 2864581 ataatagtcc cattcaaagg caacataata aattcgtgcg caaataatcg caattggaat 2864641 ggcaaacagg acaagatcaa taaacgtatc tttctgcagc ccccgttttt cactttccct 2864701 catcgctatc cacagcccga gcaaagcgcc gagaccgata atgattccgt accagtggac 2864761 ggctaacggc cccagctgaa atgctatcgg attgagtggt tctatcgctt cattcattta 2864821 acgccaactc ctattcttct tgttcaccgt cttcaatgac gtccgccagc ttgttggtaa 2864881 attgttcagc ggcattcagc cccatccgct tcaatctgaa gttcattgct gccacttcga 2864941 tgatgactgc aagatttcgg cctgggcgga cgggaatcgt cagttttgta atttctgtat 2865001 caatgatttt catggtctct tcctcaagtc cgagccggtc gtattgcttg ccctgctccc 2865061 agagttcaag attcatgaca atcgtgattc gtttattgct tctgaccgcg ccagcgccaa 2865121 atagcgtcat cacattgata atgccaaggc ccctgatctc aagaaggtgc tcaattaatt 2865181 ccggagcgtt tcccacaaga gtatcctgat cctcctgccg tatttcaacg caatcatcgg 2865241 caacaaggcg atgccctctt ttcacaagct ctagcgctgt ttcgcttttt ccgacgccgc 2865301 tttttcctgt gatcagcacg ccgacaccat atatatcgac aagaacgcca tgaattgctg 2865361 tggtaggcgc cagcctgctc tcaaggaagt tggttaaacg gcttgacagt cttgtcgttt 2865421 tcagcggcga tctgaggaca ggcaccccat ttttctcgga ggcgtcaatc agctcctgcg 2865481 ggatgggcat atctctagaa agaataatag ctggtgttac atcagtgcac agagaatcca 2865541 ttcgctgctt tttctcctct tcaggaagct gttcaaagaa agaaagctct gtttttccga 2865601 gaagctgcac gcgctccctc gggtaatatg taaaatatcc ggcaatttca atacctggtc 2865661 ttgataggtc actcattgta atcgggcggt taattccttc ttctccgctg attaattcca 2865721 aattgaactg ttccattacg tcttttgtgc gaacctttgc cacgatatgt tcctcctgtt 2865781 ccgggctgcc ccgagcttgc tcacaatact ttcattttat cactttcggg cttgaaccta 2865841 aaacagattt tataaaaggg gggaaaacac ctcagctggt ctagatcact agtctgaaaa 2865901 agagtaaaat aaaggtattc aaattccaga aaggcggatc atctatggca gagagtcttc 2865961 ttatcaaaga cattgcgatc gtgacagaaa atgaagtaat caaaaacggc tatgtcggaa 2866021 tcaatgacgg aaaaatcagc acagtttcaa cagaacggcc caaggagcca tattcaaaag 2866081 agattcaagc acctgcggat tccgttttgc ttcccggcat gattgacatt catatccacg 2866141 gcggctatgg cgcagataca atggatgcta gcttttccac gctcgacatc atgtcgtcaa 2866201 gactgcccga agaaggcacg acgagctttt tagccacaac gattacccaa gagcatggga 2866261 acatttctca agctttggtg aacgcaagag agtggaaagc ggctgaagag tcctctttat 2866321 taggtgcaga actgctcggc attcatttag agggcccctt tgtttcgcct aaaagagccg 2866381 gagcgcagcc aaaggagtgg attaggcctt cggatgttga gcttttcaaa aagtggcagc 2866441 aggaggcggg cggactgatc aaaattgtta cacttgcgcc ggaggaggat cagcattttg 2866501 aactgatccg ccatttgaaa gacgaatcga ttatcgcatc catggggcac acggatgccg 2866561 attccgcatt gctgtcggat gccgcaaaag caggggcgag ccatatgact catctgtaca 2866621 acgcgatgag cccgtttcat caccgagagc ccggagtgat cggaacggcg ctggcccatg 2866681 atgggtttgt gacagagctt atcgccgatg gcattcactc ccatccttta gctgcaaagc 2866741 ttgctttttt ggcgaaaggc agcagcaagc tcattttaat taccgattcc atgagggcaa 2866801 aaggactgaa agacggcgta tatgagttcg gcggccaaag tgtgacggta agaggacgaa 2866861 cagcacttct ttcagacgga acccttgccg gttcgatcct caaaatgaac gaaggcgcac 2866921 ggcatatgcg tgagtttaca aattgctctt ggacggatat agctaatata acttctgaaa 2866981 acgcggccaa acagctgggc atctttgacc gaaaaggcag tgtgactgtg ggaaaagatg 2867041 cagatttggt gattgtcagc agtgattgcg aggtgattct caccatttgc cgcggaaaca 2867101 ttgcatttat atccaaggag gctgaccaga tatgaaagta atggaatgtc aaacgtatga 2867161 agagctaagc caaatagcag ccagaataac ggcagataca atcaaagaaa aacctgatgc 2867221 tgttctcggt ttagcgacgg gcggcacacc ggaaggcacg tatcgccagc tgatccgcct 2867281 gcaccaaact gagaatctct catttcaaaa catcactaca gttaatttgg atgagtacgc 2867341 cggactttca agcgatgacc cgaacagcta tcacttctat atgaacgacc gtttttttca 2867401 gcatatcgac agcaagccta gccggcattt tattccgaat ggaaatgcag acgatttgga 2867461 ggccgaatgc agacggtatg aacagctagt cgattccctc ggcgacactg acattcagct 2867521 tctcggcatc ggccgaaacg gacacatcgg ctttaacgaa ccgggaacgt ctttcaagtc 2867581 gcgaactcat gttgtgacat taaatgagca aacccgccaa gcgaatgcca gatattttcc 2867641 ctccatagac agcgtgccga aaaaagcact gacaatggga attcaaacga tactctcaag 2867701 caagcgcatt ctgctgctta tttctggaaa aagcaaagcg gaagctgttc gtaagctgtt 2867761 agaaggaaac ataagcgaag attttcccgc atctgctttg cacctgcatt ccgatgttac 2867821 ggttttgatt gatcgtgaag ccgcgtcatt aagaccttga aaggaacatg ctgacttatg 2867881 aatatcaata aacaatcgcc tattccgatt tactatcaga ttatggagca attaaaaacc 2867941 caaattaaga acggagagct gcagccggat atgcctcttc cttctgagcg cgaatatgcc 2868001 gaacaattcg ggatcagccg gatgacagtt cgccaggcgc tttctaattt agttaatgaa 2868061 ggcttgctct atcgcctgaa agggcggggc acctttgtca gcaagccaaa aatggaacaa 2868121 gcacttcaag ggctgacaag ctttaccgag gatatgaaaa gccgcgggat gacaccgggc 2868181 agcaggctca ttgattatca gcttattgat tcaactgagg agctcgcggc tatattaggc 2868241 tgcgggcacc cctcctctat ccataaaatc actcgggtgc ggctggcaaa tgatattccg 2868301 atggcgattg agtcctcaca tattccgttt gagcttgcgg gtgaattgaa cgaatcgcat 2868361 tttcagtcgt cgatctatga tcatattgaa aggtacaaca gcataccgat ttcccgtgca 2868421 aaacaggagc ttgagccaag cgctgccacc acggaagaag cgaatattct tggtattcaa 2868481 aagggagcgc ctgtcctatt aattaaacga acaacatatc tgcagaacgg aactgctttt 2868541 gagcatgcaa aatccgtata cagaggcgac cgttatacat ttgtccacta tatggatcgt 2868601 ctttcataaa aaaagcctcc aacccttttt aaggattgga gacatggcga aaatcaaact 2868661 ggtctggtgc cggacgatat gtttcttttt tcgtcttgaa cttccagatc ggtgatttcg 2868721 ttttgccgtt aaaactgtct tccactataa tgtaccaata ataaacagac tgcggttcaa 2868781 gatgatccca gcggaattca gctgtgtccc cgctcttcac ttgctcccgt tttccgagct 2868841 cttcattggt atatacgtta cattcaaaat aatcggtttc cacctttttg attcttggct 2868901 tcaaatcaag cgaaagggaa aattcatcct tgttgccata ggtatccgta tcatagtagt 2868961 tcttatcctt tacatacgga gagtacgtcg atacgtgcac catgtcattg gcttggtcaa 2869021 attgaagcaa acgcaaatac ccttggccgc cttctggccc gccctgataa tcggccagca 2869081 tttgatgcac aagacgatcc ggtttcccat caccatcatc atccagctca tctgtttttc 2869141 tcatcgcact atgataatgc ccgctcaaca ccatcacgac attcgggttc ggctttacga 2869201 tttctttgaa tattttctct ccgattgggc ttctgtttcc gctgaccagc aaatactcat 2869261 gaaaagctaa aatggccatc cggtcaggat gcttcttcag cacctgattc atccacgcga 2869321 tgtcttcatc cgtaatgccc catcccatgt acagcatgat ataatcattg ccgttgctag 2869381 aaatcaggtc ataatgtccg cggttatttt tataggaacc gccataatga aattttttat 2869441 caaaacgatc gctgccaaaa tatttgccaa acgccctgta ggagccgtcc ttatgtccga 2869501 catcgtgatt gccggccagc acgccgtaag gaattccgct cttatccaga acggacattg 2869561 accgatcagc gtttttccac tgtctgatat cggcggaatc atctacaata tcacccgtgt 2869621 ggaacacata tttgatattg agctgctttt gattatcttt tatccattcg gtctgtttat 2869681 caaaaatatg cggatagctt tcggcgtaat actgtgtatc agacatccag acaaatgtgt 2869741 acatatcctt cgcaggagga atttcatcct gtacaatcac attcattttc gactcccgta 2869801 caaaatcggc ggcaatcaca gacgctttca gcgtaaacgg tttgtcatcc ttcgcgacga 2869861 agctgtcaac aggctgccat tcgtttgtcc gataattcca agcatacatc gtcacctttc 2869921 tccccggcaa agaactgccc ttccagactg attctgccag atcattctca tcaattgatg 2869981 gatcaaccgt cacttcaaag cgatgataag ggaaaagctc tttgttttct gtcgatactg 2870041 tttttccatc agcagctgat acccgctcca attctttatt cgtaaatggg gtctcccttt 2870101 ccggcacaaa gcttttcggc ggttcagtca gtgacgcgtg cttaaatatt ttcacatgat 2870161 tgcgcgctgt atattgaaat cccctataaa aaccaacatc catggcatca ttcgtcggat 2870221 ctttcacccg tacagaaagc ttggccttat gcgtgtcggc ttcgctgtct ataacctccg 2870281 gctggtccgg atgctctcgt tcggttttaa atatcctctc aatcactgtt ttattgcccg 2870341 cgagatccgt tgctgtcact tttagagaat gttttcccgg caaaaggtca gaagatgacg 2870401 tatgatatgg gagtgtaatg ctttctccat ctaacgacgc ctccgcttcc tcaattctgc 2870461 tccatttatc atacatatcc gcctgcagga taaggtttcc tttatacgtt tgcccctcgg 2870521 tgatattcgg ctcaatgtga ggtcctgaat tatctacccg tacaaccagg ctgacatttt 2870581 ccttcccgtc gcttgcttga atatggtgag cgccttcaga aagctttgat gtatcccact 2870641 ccagcagctg tgatgtaaat agtccgtcag gcagattgaa ctgaaattgc cagcttttat 2870701 tcgagcgctg attatcgcca ataaagagtt ccttctcagg agacaccctc tgatctctga 2870761 tcaccgttcc atccgataac accaatcggg cgtttttgac taagaagtca tcacggtttt 2870821 cagccgtatc aaacggagac accttcgaac ctgaacgtat cgtaatacgc tgcagctgct 2870881 tccctttccg aagcagtgtc tctggcaatg gaacagaata ggtgcggtat ttatttgttg 2870941 tatcatcgaa caccttcagc actttgcctt ccatcgttac cgcgttttta aaataaaggt 2871001 tcgttttcct cgtatcgaat gcaaaatata cttctttttc catcgcgggc tctgtcactt 2871061 gttttttccc gtcaatccat agcttaatgc tgtcagctcg cccttctgtc gtggctttga 2871121 gaaattgagt tcccgacagc gtgtctctgt tttcaatatt catccgcaga ccgtgcgcct 2871181 tgcttgtttg tttaatatca atcattttga ccggcgttct cgcttcattg atcccgtccc 2871241 cggccgccac ataatactct agctgatcct tcccgatcaa ttcaggcgaa tacacaatat 2871301 aatggaagag attatcgttg cggtcttttt cagcaagaat tcgcttaaac ggtttgttct 2871361 catccgtccg gtagtaaaag gccactgttt tcactaggct tcggtcccgt atgtcagccc 2871421 gcagctcaat gctttcagca gggcggacag gcttgcggtc agtcaaatcc tcaatgaccg 2871481 gcttttcttt atcgagcttg attttccgtt tctggtcggg cacctgtgcc tgtaatacgg 2871541 ttccgggaga cggattcttt tccccgattg aaatgttcag aagttctgct gttccgttca 2871601 gtggatactt ataaagcact gatgacagcc ggcgcagcgc atgtttccga taatgcgcaa 2871661 ccgaaatgtc ctttcctgta ttcgttgata tcacaacggc ccgcggcctc gtattggcca 2871721 taccctctgt ctcgtctatc accgcaagat tttttccttc ttttagttgt gtctgataat 2871781 aacgattgaa atccgctgac gtcaattctg gatgcccggc aggcttcagc cagacgacaa 2871841 acgtttcgcc ggatggtatc aagatccttt catcaggtct ccaaatcaga tcggagtcag 2871901 gcccttcttt tgggtagcgg taacggatat ggtagtcttt aaaatcaatc gttctgtcag 2871961 tcgtattaaa aatctcaata aattcataac cgtctgcgcg tcctatattc ttcgtatcaa 2872021 ccgccagctc tgtgatcaga agctccggaa tatgggcaag gtcagcctgg tatccttcaa 2872081 gcttcagttt cttcgtctcc gactcaaccc gctgcttccc attcgacatc acaatgtaat 2872141 actcaagctc gctgttccaa atcaaacgtt tcggaatttg tgccaaaaac ttgcggaccg 2872201 ctccgggggt cgggtccatc ggcaccattt tgtagcccag ctcattactt tgtttataaa 2872261 aaagaaaggc ggaaaatgct tgatacgaat tatcgcgaac ttgagcctca atcattagat 2872321 tgcttctcat ttcagctttc acatcaattt gaggaggatt ttcaagcaag ggtatgtaat 2872381 gaggcgtttg aaatagttcc tgctgtacaa caggaaaagc tttcgattca tgatggccgc 2872441 cagacaaaac ggaaagaaaa gacagtaata tagaagcaat aaccgtgtat ttcctcatca 2872501 aagcacctcc cttttcatgt attttgcgtc tgaacaggga agcttatgag ttcatttttg 2872561 tgcataaaga acaaaaaaac gtctgtctct tgaaaattcc actattaccc agtaaactaa 2872621 ggatagttaa ccagttaaca attaaatcag agaggcaaat tgatggacaa cagcattcat 2872681 gatgaattat ttcaagctat acaacaattc gcattaaaaa gggataaacg cgtctggcaa 2872741 aaggtgcaga taccatccat tggcatatcc tcacaacatc acgatcacct caaaaaagac 2872801 tggactttga cccagcttca cattgtttcc tgcatacata ccagccaaaa tgtgaacaac 2872861 agcttcttag catcccgttt acacatctca aaagccgctg tttcaaaagc ggttcatgct 2872921 ttgttgaaac acaatatcat tacagtgaca aaaaagcctg gcaacaaaaa agaaattttt 2872981 tatacgctaa ctgatagcgg cagaaaattg gcggcattac atgaacagct tcatgagaaa 2873041 gcaaaggagc aatataaaca gcttttcaat gaattttcaa ttgatgattt aaaaacagtg 2873101 actgcgtttt tcaacttgtg gatcaaatat atgtaaaaag agtctcaccc gcatgggaga 2873161 gacctttgga attctattat gccccgtcaa acgcaacgag aagtgaaaca ggtccgcgtg 2873221 tatacagacc ggactcagca taacaaaaat cttcctctaa tctgatattc cgcatcttat 2873281 ccagcacaat attagctaca atttcgattt cgtttttggc aaaagctgct cctacacagt 2873341 tatgaatgcc ggatccgaaa gcgagatgcc gggcggcgcc gctaaaagcg ctcttgatac 2873401 caagatcttc ccgatgaata ttaaacacgt caggctgttc aaatgcttca gggtcccggt 2873461 tagccgcacc gatcatacaa aaaacaatcg tatctttttt gatttccata ccgccgacca 2873521 ctgtatcttg ggacagctgc cgcggaatca gctgaaccgg cggtttataa cgcaatgtct 2873581 ccgcaatggc tctcggaact aacgaacggt cagccaaaac atcattcatc tgctcaggat 2873641 tgttgagcaa atggtagatc atcagtgcca gcgtcttatc agccggttcc gttgcggcta 2873701 acagcacatt aagaatcagt gcgagtatat ccttgtccga cagcgccatg ccttcatatt 2873761 cagaagtaca taggatcgaa attaaatctg atcccggatt gacgcgacgt tctttaatga 2873821 ccggcatcaa gtattgggaa agctgttcgc tgcaccataa cgaatgtgcc cgcgcttcag 2873881 gagattgaga gatactcgtg ataaaatcgg caactccgct gtgccactca gagatttttt 2873941 catggtctct tttatccagc ccgagcatgt ccatcgtgac gcacaccgca aacgtctttc 2874001 caaaatcatt gacgagatca cttttccctc tttcaagata aggcgctaac aagttttctg 2874061 cattttgttt aatcaatgga gacagatgat ccagtgcgtc accgataaag cttctcacta 2874121 caattcttct tttggcagag tgttcttttc catgcatttg ggccagcaca gggcctcgca 2874181 tgactggttc ggcacgctca acaagtgatt tcgtcgtgaa gatatccgga tgctgaagga 2874241 tatagcggac atcatgatag cggctgataa aataactgtc tatcgactct tcataatgaa 2874301 ccggatcttc ctcccgcagt tgtgaaaaat aagcatatgg attgttttga aattgatcag 2874361 aaagcacact aaacaattta atcgattggc tcatgtttta ctccccctat catccttcag 2874421 atgtgatccg tttctcagaa agcatctgcg ccatttcctg tacaatgaga tacccttgat 2874481 tcggccgcat acaaatagaa aattcatggt tactgatctt ctcacccagc ttccacggac 2874541 gatgataagc aaggagtgtc tcttccacct ctaaaatatc cggagctccg ataaaaaacg 2874601 gcagctcagc tatgacatat tccacagcca aattcagcat atcctcactg acttcttcca 2874661 tcatcaaact gacgccccgc gcacgcccga ttatcgcttc acgagacatg tccaaacaag 2874721 catgtcgaaa atgaggctgc tcaaaaaatg catgttcaac ttcttgtctc aacagctggt 2874781 aggctttgtt atctataaaa tcagaaaatg tatgaatcgc cttcggatcc ccgccatgag 2874841 ccacaagggc tctttctgca aatctcctgt ttcgtgatac ctctttcctt acttttcgtt 2874901 cagcctttcc tctcggagtt ccaagcgctt ctagaagatt agccgcctca tgccctgcaa 2874961 gtaaaactga aacgctttta aattgagctt tcgcccatcc aattaatctg taaatataat 2875021 cctctgaaaa cctgctgtta aatgggctga tccccaccaa aacatgcctg cgccgttcaa 2875081 atatttctct gcagttttct gttaatgcct cagcaataaa atgcacagac cttctttccg 2875141 ttaccattcc ggtcatctca ttcaccccta aaacttatcc cgctttaagt catcaccctc 2875201 aaatacaaga tggaatagct agaacaactg aacaagacga atggcaggca tcacttaaag 2875261 tttccaaatg ttttttaaga ttttaataat cattttcaat acccatatca tgataaatgt 2875321 ttactagtaa acattagtca ttttatccct tttccttcca aacgtcaata tgatctgtgc 2875381 ccaaatattt gaaaataaat gtaaacatca cattttccac acacttttta cacgcatatt 2875441 cagcatgaca tatcaacaaa tagtctaaac accaacaatt gacaacgaaa acaagaaaag 2875501 ataaaataaa attgttcacc agtaaacgat ttgttttatt gtttcatcgt aaactattat 2875561 tcctaagaaa gaaggtagcc tatgtctgat ttgacaaaac agatgatata cgacatatac 2875621 gtgagactgc tgcaccttaa tgaacaaaaa gcgaacactt cacttcagca attttttaag 2875681 gaggccgcag aagaggatgt agctgaaatt cccaaaaata tgacaagcat tcacgtcatt 2875741 gactgcatcg gccagcatga acccattaat aatgccggaa ttgccagaaa aatgaactta 2875801 tcgaaagcga atgtaacgaa aatcagcaca aaactgatca aggaagaatt cattaacagc 2875861 tatcagctga cagataacaa aaaagaagtt tattttaaat taacccgtaa aggcagacgg 2875921 attttcgact tacatgagaa actgcataaa aaaaaggagc tggcttttta ccaattcctc 2875981 gattcatttt cacaagaaga acaaaaggct gtattgaagt ttctagagca gttgacgtca 2876041 acacttgaag cagaacaaac cgatgggact ccagacaaac ctgtaaagta aacaaaaagg 2876101 cggtgtacac tttggctcat acaaaatcaa aggcagtatt gatcttatac actgtttgct 2876161 tcagtgcatt ttttgcatct ttaagccaga acatttattc acctattctt ccgatcatta 2876221 aagaatcatt ccatgtttcc acagctatgg tgaacctgtc agtctcagtt tttatgattg 2876281 tgacagcaat aatgcaaatt atattaggag cgatcattga ttttaaaggc gctcggatcg 2876341 tcttgattac cggtattctg gcaacggcag cagccagcat cggctgtgcg gtgactactg 2876401 actttacctt gtttctgata ttcagaatga tacaggcagc cggttccgca gcactgcctc 2876461 ttattgctgc cacaacgatc ggacagctgt ttacaggaaa tgaacgcggg agtgcaatgg 2876521 gaacgtatca aatgctcctg tctgtcgcac cggctattgc tccagttcta ggaggattca 2876581 taggcggagc agccggatac gaagggattt tttggatact tgcggccatc tctatcgttt 2876641 tgctggtgac aaacagcatc acctttccta aagattctcc aactgaatct atgcagcaag 2876701 ccaaaggcaa tgtgttcgct cattataaat caatatttac aaatcgaaca gggaacgtca 2876761 ttttgacttt aagttttgtt ctctttttca tttattttgc agtaattgtc tacctcccaa 2876821 tattgctgac agagcattac catatagatg tgggtatagc aggactgtta tatttgccgc 2876881 tggcgctgag cacgattgca ggtacgtttc tgtttaaaag aatacaggca aaaatcgggc 2876941 tgcacacctt gtttatcgga agcaatgtga ttgccgcctg cagcatcatt ttatttgctg 2877001 ttacacattc cgtttctctc gttctcatgg ctctgacgct ggcactgttt ggcatctcga 2877061 tgggggttat tcctcccttg tactctacaa tgattactaa tgaatttgag cacaacagag 2877121 ggagtgcaat cggaatgttt aactttatcc gatatacagg catggcagca ggtccgatgg 2877181 tatctgccta cttgctcaca atgatgccgt ctgccatgtc ctttagcctc ctaggccttg 2877241 gatttgccgc attgagcttt tgccttcttc cgccaatgtt ttcgccgcag aagcgcacga 2877301 aacaaaaaaa gcaccacatg taaaaaagct gcctttgcgg gcagcttttt ttattttttt 2877361 ctaagcggct ctaaaatgcc tttttgaatc agcaaatgga agaccgacag gataacggat 2877421 gcccatatcg ctgtgccgaa gccgtcgatt tgaaagctgt cacccataat ggacgcggtc 2877481 atcataagcg tgatggcgtt aatcacaaac aagaagagtc caagcgtcac catggtgacc 2877541 ggcagtgtaa atataattaa aagcggttta atcagcacgt ttaagatcga taaaatgagg 2877601 ctggcgataa tcgctgcccc aatgctgctg atatggatgg agtcaatata tccatcaatg 2877661 acgattaata acaatgcatt gactaaaatg ctgactgccc attttaccat gtcatttcat 2877721 atccctttct gacgggacga taaaaatcca aatgatataa atgagcaaaa ccggcaagac 2877781 acttgtcata atggctaaga tgacagttat gactctgagg agtgatgcgt cccaattgaa 2877841 atattccgcg agacctccga taacaccggc gattttctta tttttttctg agcgataaag 2877901 cttattcatt cgatcacctc tgtgagtact ttagtttgat ggcgcctgtt agtgattctg 2877961 agaagacggt gatgttttga tcatgtgcct gatttgaagt gaacatcatt tctttttgaa 2878021 tcgtatcatt tttttccttc agcatctcta catccattaa ttcatgggac agcgtaccaa 2878081 gattgctttt cagctctgcc ttcactgcga gatcgtccgg aattgcaagc tctacatttc 2878141 cagtcgttgt ttttgcataa atggagcggc agtctgattc tgttacgtta atcgcaatat 2878201 ttccgttaaa gctttgaacg tcaatggatt cgcttttccc tcggagatcg atcaatccgt 2878261 taatggtttc cgcttctatc gtaccgcagc tgtggcttgc gagcttaatt tgcccgttgg 2878321 ccgtttcagc tatggctttt tcggctgtta aatacgagaa cgacagcacg ccgtttgtcg 2878381 ttttcgctga gaactctttt acatgtaaat gttcccctct gactggaccg ttaaacagct 2878441 tcacccgaat cttatcatac tccttctgag gaatatacaa agtgacattc gttttcatcg 2878501 tctttttctc agtacggata aaaaacttat tacctttgat ttcacattca atatgctgaa 2878561 gaaatgcgtg tctcgccgca tcctggctgt cagcgcgata taccttcgcc tggcattccg 2878621 ctctgatatc gtcatcttcc caagggacga tatttacgct gccattggca atttgcagct 2878681 caacactgga aaagtcagta tctttaaatt gaaaaatgtg ctgaacatca tacgcatggc 2878741 caaagtttaa atcaaggtca acttccttga cctttttcac agcagaatca atccagtcaa 2878801 acagcttggc tcctaaagac ggtttgccgc tttctttttt tgccgttgta aatggctctt 2878861 cctcgtcatg aacgtgaact gagagcgctg tgattttctc ttctttttcc ttgtagtcgc 2878921 tgtcaagctt ttcaatcagt gtcaaagctt cttgtgctgt aagctttcct tcctcaacaa 2878981 gcttaaggat tcgttccttt tcttgcttca ttacgatctc ctccccattg tctacttatg 2879041 ctgcacgcag gaccttaatg ccctgaatca cattccaaat gataatgcca atgacaacta 2879101 agaaataaat aaccgctccc ccgatgatta caaatacagg aagcaagctg tctccatcaa 2879161 tcgcaacggc tccgccaagt aaagcaataa aaaggaacag ccagccgaca aacggaacaa 2879221 tgtgagaaat aagagagcgt atcgcatggc gttttgtttc tttctcattt acaacaaaat 2879281 atgcgacaat cggcacaatg attggcgcaa tgaacacact gaaataacaa agtgatgcaa 2879341 taatagcttg attacggttc aattcattcc acactcctat tgtgaattgt ccatgacaaa 2879401 agatcaggga cgttttactt atttatacgt ttaaaatctc ttcaggtttc aaattcattc 2879461 tttagacatg ctccgattta cggaaattgg attttaaaaa gttttagaag tagaatcttc 2879521 cggctatacc gattacaata tgtaaaaagc ttacggcaac caaggaggct ggacaagcaa 2879581 tggagaaaga tcccagtgac tatacagtaa cacaagaatc agtgttaaag ctgattcagg 2879641 aacaaaaaag aatgaatcgt gaaatgatca ccgagcttga gcagattcac ggacccttcc 2879701 cgatctctca cgatatccaa tatataaaag tgctgctcga cagcagcaac acacatattg 2879761 ttcaagattt aatgagtgta agtaagcagc tgtataagaa gactttgtaa ttgcggaaaa 2879821 catatcattc attataactg aaacaaagct aaaggttaga tgacaatatc ttgccttttt 2879881 tgttttgaaa aaacaagtga ttccctggct gtcacaaaat gattgtaaca aaaaaagcct 2879941 gccggcacat ccagttaatg gactctgtcg gcaagctgta actatcagaa agagatagcc 2880001 gttcaaaatt aacgtaacaa ttgaagcacg ttttgcggct gttggtttgc ttgagcaagc 2880061 atcgcttgag aagcttgaga aggaatgttg ttctttgtga actcgctcat ttctttcgcc 2880121 atgtcaacgt cacggatacg ggactcagca gctgtcaggt tttcagaaga agcaccaagg 2880181 ttgttgattg tgtgctctag acggttttgt accgcaccaa gtttagcacg ttggtttgag 2880241 acattgttga ttgcagtatc aatactttca agttgtgtat caaaaggagt attagcaaaa 2880301 tctgttacat taagtgcgtt tactcctaaa gcagttgatg acatgctgtc aatgttaact 2880361 gtaagctgct ggccagcatt tgctccaatt tggaaagtga aaccatcagt ttcagtacca 2880421 tctaataact ttttgccgtt gaattcagta cgatttgaaa tgccatcaac ttcctcaata 2880481 agcgcatcca tttcatcttt aattgcacca agatcttctg cttgttgtgt acctgtgttt 2880541 cctgcttgaa cagtaagttc acttctaaac ctattatgcc gtaaagaaaa agcttgcctg 2880601 ctaagcccaa ggatggactt gccgacaagc tgtcccctct taacagaggg ttttaagatg 2880661 tagctgtttc ttttgctttc aagagcgatt tcatgcgtgt tttgtcacgt tcgataacag 2880721 gctttaaata acggcctgta tacgattctt caacttcagt gatttcctca ggcgttccag 2880781 acgcgacaat ggttccgcct ccggctccgc cttccgggcc caaatccaca atgtaatcgg 2880841 ccgtcttaat gatatcaaga ttgtgctcaa taaccagtac agtgtctccg ttgtctacca 2880901 accgttgcag cacgacaaga agcctggcga tatcgtcgac atgcaaacct gtcgtcggct 2880961 catctaaaat gtagagcgta cgtccggttg agcgtttgtg cagctctgac gcgagcttca 2881021 cgcgctgcgc ttctccgcct gacaaggtcg tcgccggctg gccgagcgta atataaccta 2881081 aaccaacatc ataaagggtt tggagcttgc gtttgatttt cgggatattt tcaaagaaag 2881141 aaagagcatc ttcaaccgtc atatcaagca catcagagat gctttttcct ttgtacgtca 2881201 cttcaagcgt ttcacggtta tagcgtttgc cgtgacacac ctcgcatgga acgtatacgt 2881261 caggaaggaa gtgcatttca attttaataa tcccgtctcc gcggcaggct tcacatcgtc 2881321 cgcccttcac gttgaagctg aaacggcctt ttttatagcc gcggaccttc gcttcatttg 2881381 tctgcgcgaa tacatcacga atgtcatcaa atacaccggt gtatgtcgca gggttggatc 2881441 tcggcgttct tccgattggc gcctggtcaa tgtcaatgac tttatctaaa tgatccaaac 2881501 ctttaatctc tttatggctg ccgggcttcg ctttcgcttt atgaagcttt tgcgccagcg 2881561 ccttatgcaa aatttcatta acgagtgtac tctttcctga accggaaaca cctgtaactg 2881621 ctgtaaacgt cccaagcggg aacttggcat tcactttttt caggttgttt tctgatgcac 2881681 ctttaatttc aatgtaacgt ccgtccggct ttcttctttc aggaggcaat gggataaact 2881741 ttttccctga taaatagctg cccgttaatg aatttggatc ttccatcact tcttccggcg 2881801 tacccgcaga tatcacctgt ccgccgtgaa tgccggctcc cggtccaata tctattaaat 2881861 aatctgctgc catcatcgtg tcctcatcat gttcgacaac aatcagcgtg ttcccgaggt 2881921 ctctcatatt tttcagagcg ctgatcaagc ggtcgttatc acgctgatgc agaccgatag 2881981 acggctcatc taaaatataa agcacaccgg ataaacgcga gccaatttga gtcgccagcc 2882041 tgatgcgctg cgcctctcct ccggacaatg tacccgctgc cctgctcaat gtcaggtaat 2882101 cgaggccgac tttgtccaga aagcttaagc gctccacaat ttcgcgcaaa atcaaattgg 2882161 cgatctgcat atccttctca gaaagggtaa gatctttaaa gaaggcaagt gcgtcggcga 2882221 cagacagctc ggtaattttc ccaatgtggc ggccgtcaat cagtacggca agcgcctctt 2882281 tctttaaccg atagcctttg cacgtcggac aagacttctg agacatatac tgctccattt 2882341 gctcacgtat gaaatcggag cctgtctcct tatagcgtct ttcaatgttg cgcaatacgc 2882401 cttcaaattg aatttcacct tcgcggattt gtccaaaatc attttcatat cggaaataaa 2882461 tcaggtcatc cccgctgccg tacagcactt tatccagttg atgcttcggc aaatctttga 2882521 ccggcacatc catatcaatc ccgtagtggg tgcagactgc ctcaagcagc tgaggataat 2882581 attgtgagct gatcggtgtc caaggggcga ccgcattctc cttcaatgac aaatcttgat 2882641 tggggatgac aagatcggca tccacttcaa gcttcattcc gagaccgtca cacgtcggac 2882701 acgccccgaa cggactgtta aacgaaaaca gacgcggctc aagctcacca attgaaaatc 2882761 cgcagtgcgg acaggcatga tgctcgctga acatcagctc ttcctcaccg atgacatcga 2882821 tcataacccg tccttcacct aaacgaagcg ccgtttccaa tgaatctgac agccgggctg 2882881 ccacgccttc tttcacgaca atccggtcaa tgactacctc aatggaatgc ttcttgttct 2882941 tttctaattc gatatcgtcg gaaagctcag ccatctcgcc gtcaattctg actctgacat 2883001 agccttgttt cctaatctgt tcaagcactt tgacatgagc gccttttcgg cccgagacaa 2883061 tcggcgccag cacctgaagc ttcgtccgtt ccgggtattc cagaattctg tccaccattt 2883121 gctcgatggt ctgggatgta atctcaattc cgtgttccgg acaatgaggc ttccctactc 2883181 tcgcatataa aagacgcaga taatcataaa tctcagttac cgtaccgaca gtagacctcg 2883241 gattgcggct cgttgttttc tgatcaatgc tgatggcggg agagagcccc tcaattgcat 2883301 ccacatccgg cttatccatt tgccctaaaa actggcgggc ataggcagac agcgactcga 2883361 cataccgtct ctgtccttca gcatatatcg tgtcaaaggc aagggaggat ttacctgatc 2883421 cggacaaacc cgtgacaacg acaagctgat ctctcggaat cgttacatct atatttttca 2883481 ggttatgcgc cctggctccc ttcacctcta tccgatccat agccatttgt tcatcatcct 2883541 tccgctttta gctctaaaag taaatcgcga agctccgcgg ctctctcaaa gtcaagcgcc 2883601 ttggcggctt ccttcatttc atgctccatc tgttcaacga ctttctggcg ttctttcttc 2883661 gtcattttcg acagcttcgg cgcggctttt gttttgtatt ccgctttatc ctcagctgct 2883721 actgtggcac gaatgacatc gcgaatttct ttatttatcg ttttcggcgt aatgccgtgc 2883781 tcttcgttaa accgctcctg ctgctcgcgg cggcgttttg tttcattaat cgcaatttcc 2883841 atagacttcg ttattttatc ggcgtacata atgacgcggc cttccgcatt tctcgctgcc 2883901 cgtccgatgg tctggatcag cgaccgctcc gaacgaagga aaccttcctt atccgcatcc 2883961 aaaatcgcaa caagggatac ttcgggaatg tccaaacctt ccctcagcag gttgatgccg 2884021 acaagcacat cgtacttgcc aaggcgcagg tcgcggataa tttcaatccg ttcaagcgtc 2884081 ttgatctcag aatgcagata gtttacttta atgccgattt cctttaaata atcggtcaga 2884141 tcctctgaca tcttcttcgt caaagttgtc acaagcaccc gttcattccg ctcgattctt 2884201 gcttgaattt cgccgatcaa gtcgtcaatc tgaccttcga ttggacggac gtcaataagc 2884261 gggtcaagaa gccccgtcgg acgaatgatc tgttcgacca tttcatctgt atgttcaatc 2884321 tcgtacggcc ctggtgttgc tgatacatac acgatattgt gcatatgctt ttcaaattcc 2884381 tcaaaacgaa gcggacggtt atcaagcgct gatggaagcc ggaagccgtg atccacgagc 2884441 acctgtttcc gcgcctggtc tccgttaaac atgccgcgca cctgaggaat tgtcacatgc 2884501 gactcatcca ccacgatcat aaaatcgtct gggaaataat caagaagcgt atacggcgtt 2884561 gaacctggag gccgcagagt caaatgtctt gaatagttct cgatgccgga gcagaaaccc 2884621 atttcacgca tcatttcaag atcatatctt gtccgctgct ctaaacgctg cgcttcaagg 2884681 agctttccgt tttcatgcat gaccttcagc tgctcctcaa gctccttctc gatattttga 2884741 atcgccttct ccattttctc ggcccgcgtt acgaagtggg atgccgggaa aatcgcaaca 2884801 tgatctcggt cgccgagaat ttctcctgtc agcgcatcta cttcccgaat ccgttcgatt 2884861 tcgtcaccga aaaattcaac tctgacacaa tgctcatcac gggatgccgg aaagatttcc 2884921 actacatccc cgcgcacacg aaatgtaccg cgctgaaagt cgatatcgtt gcgggcatat 2884981 tggatgtcta caagttttct gagcagctcg ttgcgctcaa tttccatttc agtccgcagt 2885041 gacacgacca tttcccggta ttcctcaggc gaaccgaggc cgtatataca agacacactc 2885101 gcaataataa tgacatctct gcgctcaaac aaagctgatg tggcggagtg tctcagttta 2885161 tcaatttcat cattaatact agcgtctttc tctataaatg tatccgtttg aggcacatac 2885221 gcctccggct gataataatc atagtagctg acaaaatact cgacagcatt gttcggaaaa 2885281 aattccttga actcactgta aagctgtcca gcaagggttt tgttatgggc aatcacgaga 2885341 gtcggcttat tgacttcttt aatcaaattg gacaccgtaa atgttttccc agttcctgtt 2885401 gcacccagca gagtctgatg cttcttgccc tcctgaattc ctttcacaag cttttcaatg 2885461 gctttcggct gatctccctg gggctgatat ttcgagacta actcaaagcg atctttcaca 2885521 aaaataagcc tccgtttctt taacgaaatc ttcctataga tatagtaaca caatggaaag 2885581 caaaatcact aaaaatacga actaaagttc ggtggttttt tatttccagc tgtttttgtg 2885641 tataaaaaac ctgcttttaa aacgtaaaag caggtattca gtctttatat tcattatgtc 2885701 cgatttattc ttcttttttc tctgcagctt ttttggccat atacagtccg ccagccacaa 2885761 gagacacaac atccaatcct acaataaaat acgtttctgt atagcctttt aaataagagg 2885821 caaacagcaa tgcagctgtt aaagcgatcg ccacataatg attaaaggtg actctagtaa 2885881 atagaacaac aagcataaaa gggaaaaaca atgcaaaaac ggcttttgta atcaacaaaa 2885941 accctcctca gggattcttc atctgatctg attatagtaa aaaatgaaga atcggacaat 2886001 cgtgcattcg ctccctctac ttacaccata ccccttttca gccaaaatca atcaccatat 2886061 ttgcattttg gtgccggtca aaacttattc catggtgccg ctgttctaat cagcggcact 2886121 ttttttatta catcatcaag tccgccgcca gattccgaga ataaaagaaa ataggcatac 2886181 agtaccagta cggccgcatt tttcaggata atataaccaa cttaactatt cattttattt 2886241 aggactttct gcgtttgaca gcattttcct gaaaacctac aattaaatga tagtgtttac 2886301 tatcattttt taaacacagg ctccgcaata aaaagactag agagaaaaac aaaatgaatg 2886361 aagaaaagag gggtttcaaa tatgtattct gttttatttc gccaggcaga agagtccagc 2886421 cagctggctg gagcaaaagg aatgaatttg attaaattga ccaaacacgg tcttcctgtt 2886481 ccggacgggt ttattattca aacgaatgcg ctcgcacgtt ttatggagga caaccagctt 2886541 caagagacta gtgaaaacgt cgaaggcggg atcatttccg gaacattttc ggatgagctg 2886601 aaagatgagc tgactagttc cttttataag cttagagaat catatcgatc cgtagccgtg 2886661 cgttcttcgt ctgcttcgga agatttagaa ggcgcctcat tcgcgggtca atatgaaacc 2886721 tacttaaata tcaaaacaga ggaagagttt ctggctaaag tgaaagaatg ctgggcctca 2886781 tttttttctg ggcgggtcag cagctataag aaaaaaatga acaatcaaat cgcagagccg 2886841 ttaatgggaa tagtcgttca ggggctgatc gattcagaaa tgtcaggtgt tatcttcagc 2886901 cgcaaccctg ttacccatga tgatagagag cttttaatca gcgccagcta cgggttgggt 2886961 gaagctgttg tttcaggaaa tgttacccca gacacgttca ttgttaataa atcttcgttt 2887021 gagattcaga aagaaatagg tgcaaaggaa atctacatgg agtctgcggc agaaggaatt 2887081 gctgaaaaag aaacgagtga agacatgcgc agccgttttt gccttacaga tgaacaagtg 2887141 attgaattgg ctgaaatcac aaaaaaaacc gaagacctgt acggatatcc tgttgatata 2887201 gaatttggaa ttgctgatca tcaaatatac cttctgcaag ctcgcccgat tacaaccatt 2887261 gatcaggaca aaaaagcggc agaagaaaaa cgcagcttca tgattaccga cactgatatg 2887321 aatgatttct ggcttaacat ggagtctaat attgaaggtc cggtgagtcc gttattttca 2887381 tccttcatcg tgccggcatt ggaatatggc ttgaagaaga gcatgcaaaa gtttccgatt 2887441 ggtgtagttg ttgatgaagt aaaactttat cgcggacata tttattccaa aaaccaaggc 2887501 ggacagcagc ctccttctga agactgcggc aaagagcttt tcccgatttt atcggagcat 2887561 atgtatgaca tcatcaatca cacatacctc cctttttacc ggacactgga ccagctcgca 2887621 caaactgagc ataccgcaga aagcgcactg gaagcttttc aaaaactaaa ggccttttat 2887681 ctcacggctt atgaagagca ctttaatatc gttttcccgc aaatcctttt aacaaacaaa 2887741 ctgcaagcga tgtatcagga cattcaagga gagtccgaaa acgctcattt ttacgagatg 2887801 ctgacaggaa aaatgaacaa atcactggaa acggaccgtt gcttatggct attttctgtg 2887861 gaagttcagg agaacccgaa ccttctggcc atttttgaaa acaacaagcc tgaacagctc 2887921 caggagaaat tggaacaaac agatgaggga agacacttcc tgaagaacgt ccatgaattc 2887981 ttgcaagaat acggatggag atctgttaaa agtcatgatc tgattgaaca aatctgggtg 2888041 gaaaatccgt atttcgctct ggccaatatt caaaattatg tccgtaatgg ctatcatttt 2888101 gacaatgaat ttcagaaaac aaaagaaaaa cgagagaaat tatacaatga attcttggaa 2888161 agcatagaag atcccggttt acgcaccgaa tttgaccgct attatcaatg gacactgaac 2888221 tctgcaaata taaaagatga tcaccacttt tatattgacg ccatgctgga tgccaaggcg 2888281 agaatctttc tgctgaagat aggtgaattg ctggcggaaa acggtgtcat tcaagatcgg 2888341 gaggaccttt ggttcttata tgacgacgaa gtggaacaag cgcttcttca ccctgtatcc 2888401 ctgcaagaaa aggctgaaaa acgcagacag atttttcatg agtatgagct ggcccaagcc 2888461 ccggcctacc tcggcacccc gacaaaagaa cagctcaaag cagctgaaga aattgtcggc 2888521 gctgtgatag aggatgaaaa aaacacagag aatcatattt ttggcattgc ggcatcaagc 2888581 ggcattgcga caggtccggt gaaaatcatt cgggacgcca atgaattttc tcaattcgcg 2888641 cctggagacg tactcgtttg caagatgacc acaccgctat ggaccagcct gtttcaagac 2888701 gccaaagcga ttattacaga cacaggcggc attttgtctc acgctgcgat tattgcccgt 2888761 gaatacggca ttccagccgt tctcggcaca cgcacggcaa ccgaaagact gcgagacggt 2888821 gacatcatca ctgttgacgg aagcagcggc aaaatcacag ttgtcagccg gtcctgatgc 2888881 gtccccctct ttcttataca agcggggcgg gtgtatactt gtcctgccag tatattcgtg 2888941 aggtgaaacg tattgagacc gacaaacaag agaatccttg atgctgccat gcagctgctc 2889001 gtcaaaaaag gatatcgcgc aacgactaca aaagaaattg cagaaaaagc aaatgtaagt 2889061 gaagcgacga ttttcaggaa ctttaaaaac aaacaaggac tagttgaggc tttgctttct 2889121 cagcattctt caaacagagg cagcattttg gaacaaacag aaggggattt gtacaaagac 2889181 ctgcttcata tcggaacctg tctcttggag gagctcgaac atagaaaaga tatcattaaa 2889241 atcagctttc gtgaaccggc catgtttcag gatgtcatta accacgtcac tgaatatccc 2889301 caatctatga aacagctatt ggttgattat ctcaaaacga tgggtgagaa aggggttatt 2889361 cagacaggaa atgaagcgga acatgccgac gtgttcatgt cgattatctt cggttatttc 2889421 attcaccgtc tccacttagg agaccgggtc atatcaatgc cccaggaaaa aatgctggag 2889481 catagcacag ctctatttgt caaaggaatt tctgctgatt aactccttgg cataataaaa 2889541 aggaggatcc caatgagctc aagaaaagaa tgggcgctga tcgtctcgct attattgggg 2889601 gccattctgg ttcccattaa ctcaacgatg atcgcggtcg cgctctcatc tatttcccat 2889661 acgtataacg agtccatcgc aagcatcact tgggtggtta ccgtttattt aatcgtgatg 2889721 gcagtcacac agccgattgc aggaaagctc ggtgacatgt acggcaataa aacaatgtac 2889781 ttatggggag tcggcctttt tctaatcgca tctctaggct gcgccctttc accgagtctg 2889841 ctcctgttaa ttgtctttcg ggcattgcag gctgtcggcg gggcattgct tacgccaaac 2889901 agcattgcca ttatccggca tgttgtttct gaaaaacgcc taccgaaagt gtttggattt 2889961 ttcggactgg gcgcgggact tggtgcagca ctcgggcctt ttatcggctc tatactgatt 2890021 gacagcttca gctggcattc gattttttgg gtcaacatcc cgttcctcgc cattgcttta 2890081 tttacggcat taacgatgtt tcctcaatat aaagaaaata aatctgacgc gccgctggat 2890141 atcatcggct ctctcttgct tgcaggcagc atcgtttcca ttatcctgct gacgaaaaat 2890201 gaggctccat ggggatatac tgtatacagt gtattgatac ttctttttgt tccgcttttt 2890261 ttcagaagag aaaaacgtac ccagcacccc atcattgact ttgcactgtt taaaagctca 2890321 acctttacaa atgcgaatct atcagtcttg ttaagcaatt tgatgatgta tgccgtctta 2890381 ttgattatgc cgttatttat gacgaaccaa tttgggctta atacatctaa cagcgggatg 2890441 gcgctttctg tattttcgat cttcatgtca gccagcaact gggtgggcgc gcagctccat 2890501 cacaaatggg gagccaaaaa aatcattttt ctttcatttg ccatgatggc tggtgcgaat 2890561 ctattatttt tgctgttaag cagctcgcat tctgtcttgt tcctcatgct ctctcttatc 2890621 cttggcgggc tcgcttccgg agtcggtctg accagcatgc aggtttcatc ccttgccaca 2890681 gtagaccccg gtatgtcagg agtggcatct gggattttct cgaccttccg ttatttcgga 2890741 agcatcattt catcagcctt aattggcctg atttcgggat atcacaccct atttatgatt 2890801 ctctttgctg tatccatcat cggcgttttt gtttcattgg gcatcaaatc tgatgaaacg 2890861 gcacggatag aaaaaaactc agcgtaacac aaaacagccc ggcatcgcat catcctgcgg 2890921 tgccgggctg ccttttatga tcccgaagcg actgcttcgt cttcacggtc atcctttacg 2890981 aagaggatgc ccaattcatg atgttctcct tcataagaag ctcgctggtc aaaacgaatt 2891041 tctccattca aaccgataat ttcaagcttt acatatgcac ggttatgctg aagcgcttca 2891101 tagaaatcag aaacgttctt aaccggtatg ccattgactt tcgttatgat ttccccgatt 2891161 ttcaattcca gatcctcagc cggcgtattg gggataatcc caagcaccat taagccctga 2891221 tcccttttcg agaaataaaa cggagccgcg ttatcattca ctctttgctt tatggacaga 2891281 aaaatacgcc ctaacaaagc ggtacagacc gctgcacccg caagcggcgt ccacagtaag 2891341 ctcgctgcac cgagaactgc gacggcaaga ccgagaatac aaacgcgttt cgctgtgatc 2891401 cttatactcg tttcaggcag cgatccctgt accctttgtc caaatccgac aaagtaagga 2891461 atccatagaa aatggaatga gccgccggga accgtaaaca cgggccacca gctaaggtgc 2891521 gattctaaac cattaccggg cacgagaagg aacagcggca aaagccaaac ccggtttgcc 2891581 agctgctgtc cgatcggcaa accgcggctg cttacgacaa gtgccggtga tgttctcaca 2891641 tgcgcagaac gataagcaac cgctccttca gtgataatca gcaaacctag aaacacagcc 2891701 acagccggcc aaacaactgc aaatccttgc ggaaatctct ccagaaaggg ctccgcctga 2891761 tatatttgca gtccaaaacc tatcagcata ctcacactga cgatatatgc agcagacatc 2891821 cagtttgcgc gaagagtgaa cgctgccgct gcagtgataa cggcaataat cgcaagtaaa 2891881 ccgagaggaa tcgatattcc gagtccacct aaaataactg acaaaagaag acctggaatc 2891941 agtccctttg tatatgtaaa tttcagatca tcataaatat ctgctattct tgtatgaaag 2892001 gtttttcgtt cccgtttgat tcttacatag ccgaaagcca aggttatgat gataaaaaac 2892061 cagaaaagcg ggtgtaagaa gaacaagccc gcgcttttta acagttcaat tccccattga 2892121 acagacacta tctctcaccg cctcaagcca aacatgttac tcatattcta tcaaatatta 2892181 aatggcttgg atatcctcag gagagtttat ctctcttgcg tcatccacag cgtgacattc 2892241 gatagtgaaa aatcctttaa atagtggttt acatccacat ccaataaccc gctgattaga 2892301 tgcatcgacc tttttatatc tgtcagatta attcctaatc gcttatggtt tttcattaag 2892361 tagttaaaat aatgtttggc gcattcctca ttaatgtcat ttactgattc gacattggtg 2892421 taattgacca aatatctgct gaacagcata agaagactta gtgcttttgt agctgaaaat 2892481 gttacgtctt gtgttctgtc ttttaattgt tccactaatt cataatattt ttttttcacg 2892541 cacaatactt gccctcttca attgtgaacc cccattttct ttatacagat aagcacgggc 2892601 cagtataagc agcagtactg gagtgctaac aagcattctc gctaacgtta ctctttaaat 2892661 acctgtcgtt cagctgccat taacctgatt actgttcttt ttagaacctt cttatattgt 2892721 atgaagtaaa caaagactag gcaacttgca aaagtttcat tttaaatgca tattaactcg 2892781 ttagaaagtc tctctcatat attgatatcg ggtaataaca gtcctttata aatgtttatt 2892841 tgtgaaaatt tttttaattt cttgtcaaaa actcattttt tatgtgactt atgatccata 2892901 atctctttaa gcacaaagaa acaggagatg aaataccatc tcctttaatt gacaaataat 2892961 gatttcaatg ctgtttgaag ctgcaaatca tttttttcat ctgatttttt cttttctatc 2893021 tgctgattta atgtctctgc agtgcgagtg tcgatcacac cggttttatt cagcttgttt 2893081 tgatcctgaa aagccataac cgcttttttc atgtctttgc tgaaatagcc atcctcacgt 2893141 cccggatcaa agctgagacc ttttaacaat acctgcgcat gcttgacgtc ttcattgttc 2893201 atgtccactt taagcggctc tttcagctgt aagggcccgg cggaaaaata atcgggctgc 2893261 ttaatcgcaa tggtcggttc aattcctttc ttatgaatcc agtttccatt tggcgtcagc 2893321 cacttgtaaa gcgttaattt gatgttgctg ccgtccccca ttggcacagc ctgttgaacc 2893381 gttccctttc caaaagacgt atcgcctaca acatcataat ggccagcttc ctttaatgcg 2893441 ccggcaagaa tttctgatgc agaggcactt cctttatccg taatcacatt gacagggtac 2893501 gcttttttat gggtcaatgt tgaaaaataa cgttttttat ctccattgcg ttcagcaatc 2893561 tgaatatacg gctgatcctt tgtaacgaaa tgcttaagaa tttcttccac actttgaaga 2893621 tatccacccg ggttgccgcg tacatcaatg acaagtcctt ctatttcttt tttctcaagc 2893681 tccctcagcg cttttgcaaa atcctctgcg gtgtgctcag aaaaagtaga gatggcaata 2893741 tatccgacag aatgcccctg tacttttttc tctgatgcaa aaaccgtttc gagcggaatc 2893801 tcagctctct tgatccggaa tgacaactgc ttcttcgttc caggccgctg aatcttcatt 2893861 gaaacgctgg accctttttt tcctcttatt tttaacacag cgtggtttaa atccttgccg 2893921 gccatcgatt ctccattgat gctgataatt tcatcattag gcttcaaccc ggctttttcc 2893981 gctggcgatt tcttgaatgg agaaacaata ataattttgc cgtcttccat tccaacctca 2894041 gccccgatgc cttcaaatga ggaatcaaga gaatcagaaa attgcttagc tgtctgcttg 2894101 tccatgtaaa cagaataagg atcatttagc gtagacagca ttccctggat ggctccctcg 2894161 agcagctttt ctctatctac tttttctacg tactcattcg aaattaactc atacgctttt 2894221 tcgattttgt ccatagcttt atcccgttca gagtcagctt gtgccgtcgc gggaactgct 2894281 gcagtctggg gcttatccat ctcaagcagg ttgattcccg catatacacc ggcgcctccg 2894341 aacagcatgc tccctgctgc tatcacagcc attatttttt gattcatcct ttactcctcc 2894401 tgtatgccag actgtcttta ccaaaaccta gagatagtat atgtaaagga tggagatttc 2894461 atgtaatcat agaagaaaaa gaaggcaaat gaaaagccgt cccgaaaacg gaacggcttt 2894521 ttcactttat actcgcagaa acttgcggat ggaagtcaga cttccccata ctccaattac 2894581 tgcgccgatt gcaatcagca ctagcgaaac ttggaataca aatggattat aaggaagaag 2894641 agagacaaat gatccttgaa cctttggaac gacccatccg atgacgtatt ggtaagtgct 2894701 cagcaccagt gcaatcggaa tcacagaacc gaatacgcct agcagcaatc cttcaaggaa 2894761 aaacggccag cggataaacc agtttgtcgc gccgacaagc ttcatgattt caatttcttt 2894821 tcttcttgcg aaaattgtaa ttttaatggt gttggaaatt aagaacatcg ccgtaaatac 2894881 caggccgata attaacgcga ttccgatgtt gcgggaaacg ccgaccactt taaacaaacg 2894941 gctgacctct tcttttccat aagtgacttt ataaacatga tccatttttt cgatcttttt 2895001 cgccacgttc ggcgtatcat gcggatctgt cgttttgacg acaaacgcat cattaagcgg 2895061 gttttcctga tccttcattg tcagggattt tccgctgtca ccaaaactgt caaccagctg 2895121 gtcaagctct ttttctttag atgaaaaagt gacactctga atgcccttca gttccttaat 2895181 atcgttctga agcttgtcct gtgccttctg atctgcagtc agatcaatca gcactttgat 2895241 ttcgacttgt ttttctgcat tcgtggccat gttattcaaa ttcagcataa tcactaaaaa 2895301 cacgccgact aaaatcagcg taacggttac agcactaatg gatgcaaatg tcatccatgt 2895361 gtttctcccg agagatttaa aactctcacg caagtggcgc ccgagaattt taatcatatg 2895421 aaccatactc ccctcttgac tcatcacgca caatgatacc atcttcgatt gcaatgacac 2895481 gtttcttcat ggtgtttacg atttctttat tatgtgtcgc catcacgact gttgtcccgc 2895541 ggttgttaat ttcctccagc gtcttcatga cttcccagga cgtatccgga tcaaggtttc 2895601 ctgtcggttc atcagcaatg acaacatcag ggttgttcac aattgatctg gcaatagata 2895661 cacgctgctg ctccccgcct gaaagctggt caggaaattg tcgcgcttta tgcttcagct 2895721 gcacgagatc aagcacttca agcacccgtt tcttaatgac agacggctgt tctccaatca 2895781 cttcaagggc aaatgccaca ttttcaaaaa cagtaagttt cggaagaagc ttgaaatcct 2895841 gaaagacaac acctattttg cggcgcacga aaggaatctc tttttcttta attgtcgcga 2895901 gatctttatg attgattaaa atttgtcctt ttgtcggttt ttcttctctg taaatcattt 2895961 taataaaagt agatttacct gctccgctcg gaccaacaac atacacaaac tcgccgggat 2896021 gaatggtaac agaaatccca ttgagtgctt ttacgccgtt cggataggct ttatatactt 2896081 ccttcatctc tatcatgaaa tcacctaatc ttttatatca ttttatctat cacacggtca 2896141 tactcttcga atgcattcga caatttatga cccattcatt tgtaaaaaga tgaaaaatct 2896201 gaaagttccc tttttcaata cacttcatta tacgtcaaat ttagacataa tactattaca 2896261 gtttcttttc attcatattg tcaaggcata aaaacatcct tgccagcact cggcaaggat 2896321 gtttttatct tacttttttt ctgacagcca tttggcaata acagcggctt cgttatcatc 2896381 tacaagcccc tttggcatat tgccgcggcc gtttttaata atgctttcaa ttttgtgttc 2896441 atcgtatttg cctccgacct cttggagatt aggccctgac acaccttcta aatccttgcc 2896501 gtggcagcct acgcagcttt gctgatataa ttcttcccct tcagatgcag tggcttccgt 2896561 cttgctgcca gtgtctgtct tctcttcttt tgcatcgttt gatccgcagg cagccaacag 2896621 aacagaaagc gcaaatccaa tcattagtat cgataacttt gatttcatgt tgagaagcac 2896681 aactccttta cgatctcttc catattataa cctcgtttaa gcgcgtttga aaccctcgcc 2896741 cagcacctcg ctcgcgtctg ctacaattac aaaagctgac tcatcaatct gtttgacgat 2896801 ttgtttcaat ttggtgaatt cagtttgccc aaccacgcac attaaaatcg gacggtcatc 2896861 gtcagtatat ccgccgactg cagaaatttt tgtcacgcct ctgtcaatct tctgtaagac 2896921 agcctccttg acagcctgct cctgctttgt aatgatgagc gccatttttg aacgattaaa 2896981 gccgacttgc acaacatcaa tggttttgct ggacacatag acgccaagca tggcatataa 2897041 gccttgctca atattaaata caatcatagc cgtaacaacg atcattccgt caatgatggc 2897101 gagacacttc cccaatgaca gaccggagta cttatgaatg atctgtgcag ccaaggctgt 2897161 acctcccgtc gaacctttcc ctaagtacac aataccaatt ccgataccta tcccgacacc 2897221 gccaaaaatc gccgccagga gttcatgatg agtggcgggc tgaatatccc ttgtcagaaa 2897281 cactactagc ggcaaaaaca cagaacctgc aagcgtcttt agtccaaatt tcccgccgag 2897341 caaaatgacg ccagcaataa ataaagggat attaataatc cactgtacat acgctgcttc 2897401 aaaaccatat gattgtaaaa tcgtactgat cccgctgacc ccgccggcgg caatcttatt 2897461 cggaagcaaa aatacattaa aggacacggc cgtaatcgct gctcctatca atatgtatac 2897521 ataatcccgc aaaatccaca atgttttatt ccgtacgtcc atcatatatc ctccgtttct 2897581 tccaatgctc tccgatagca ttttaatcct tccctgatta gatgtaaata acacccaaat 2897641 acagtggtaa tatgctaaag cagcagtgaa atcaaggata taagaaataa aaaaacacac 2897701 ccgtatgcat caggtgtgtt tttcagctta tgaaagctta gaacgcaggt aggcatcaat 2897761 aaacgtatca atgtcaccat ccattacagc ttgaacgttc cccatttctg tattggtccg 2897821 atggtctttt accatggaat acggatggaa tacataagaa cggatttggc tgccccagcc 2897881 gatttctttt tgttcaccgc gaatttcatc cagctctgcc tgctgctctt caattctgcg 2897941 ctgatacagc ttggccttca gcattttcat ggctctttca cggtttttaa tttgtgagcg 2898001 ctccgtttgg catgtcacaa ctacgttcgt cggcaagtga gtaatccgaa cggctgaatc 2898061 cgtcgtattg acgtgctgtc cgcccgcgcc gcttgcacgg tacgtgtcaa ctttaatatc 2898121 ctccgtacga atatcaatat caatttcatc gttaaattca ggcatgactt cacatgaaac 2898181 gaaagatgtg tggcggcggc ctgatgaatc aaatggtgag atccgcacaa gacgatgaac 2898241 acctttttct gctttgagat acccgtaagc gttgtgtcct ttgatgagca atgtcactga 2898301 cttgattccc gcctcgtcac ctggaaggta atcgagagtc tctactttaa agccgcggcg 2898361 ctctccccat cttgtataca ttctaagaag catagagccc cagtcctgtg actctgtacc 2898421 gccagcacca gggtgcagtt ctaaaatcgc gttattttta tcatacggct cgctgagaag 2898481 aagctgaagc tcaaactcat tgaactcttt tgttaatgac tttagttctt tttcaagctc 2898541 aagctggaga tcagtgtccg gctcttcttt caaaagatca tgagtcattt gtaattcttc 2898601 gtgggattca ttcaattttt tatacgaatt gacataatcc tttaaaccgt ttgcttcatt 2898661 tataaccgtt tgagcttttt gctgatcatt ccagaattcc ggatcagcca tttgttcatc 2898721 tagctcagca atgcgggcct cctttgattc gaggtcaaag agacccccta aagtccgcta 2898781 aacgagaagc catattttcg agctctgctc taatttctga taattccatt tcattcacct 2898841 cattaaaaga tccgcaggcg cctgcaggcg ccgcggtcag taaacttgcc ggggcgaact 2898901 attcagtacg gccgcagcaa tttttatatt ttttcccgct tccgcagtgg catggggcat 2898961 ttcgtccgat atcaaccact ttgcgaaccg gtgctttctt tgcttttttg ttatcgtcgc 2899021 cttcttgcgg ctgatgagct gttgtttgac cttgtacaac ctcttcacgc tccagattgt 2899081 tttcaatctc agctttcatc acaaattttg cgacttcgtc ctcaattgat tcaatcatat 2899141 gctcaaacat cgcaaaacct tccatttgat actcacgaag cgggttcgtc tgcgcgtaag 2899201 cacgaaggtg aatcccttgg cggagctgat ccatcgcatc aatatgatcc atccatttag 2899261 aatcaacggc acgaagaacg ataacttttt cgaattcgcg catttgctct ttgccgaatt 2899321 gctcttcctt ctcattatat tttgtgatga tgcgatccat aatgagctca agcatttcat 2899381 ccggttcttt gccgaagata tcgctcttct caagtgcacc ttcatcaaga taagttgtgt 2899441 tgataagatc aactagaccg tcaagcttcc actcctcagg aagctcttct cttggcgtat 2899501 aggctgcaat tgcgcgttcg agagaagact tgatcatatt ttcaacgatt tcacgcaggt 2899561 tttcagagtc aatgacttca aagcgctgct tataaatgac ctcacgctgc tggcggagaa 2899621 catcatcata ttgcagaagc tgtttacgcg aatcgaagtt attgccttcg acgcgttttt 2899681 gagacgattc aaccgcgcga gataccattt tgctttggat tggagtagag tcgtccatgc 2899741 cgaagcggtc aagcatcgcc attgtccgct cagctccgaa tctgcgcatc aattcatctt 2899801 ccatagaaag ataaaattga gtaatccccg ggtctccctg acgtccggaa cgacctcgaa 2899861 gctgattgtc aatccggcgt gattcatgtc gttctgttcc gactacagcg agcccgccaa 2899921 gctcttttac accttcgcca agcttaatgt ccgttccgcg ccccgccatg ttagtcgcaa 2899981 tcgtaactgc gcctttttgg ccggcctctt caatgatctg cgcttcacgt tcatggtttt 2900041 tggcatttaa cacttgatgc ggaattcctt tgtttttaag cagcttagaa atcaattcag 2900101 atgtttcaac ggcaaccgta ccgactagaa caggctgtcc cgtcatgtaa cgctgtgcga 2900161 catcctccgc aactgcctta aactttcctt ccatcgtgcg gtaaattaaa tccgggcggt 2900221 catcacggac aacaggcctg ttggtaggga tcgtgacaac ctgcatgttg tagatgttgc 2900281 ggaattcttc ttcctctgtc ttagctgtac ccgtcatacc ggcaagtttt tcgtacattc 2900341 ggaagtagtt ttggaacgta atcgtcgcca aggtcatgct ttcgttttga atctcaagcc 2900401 cttcctttgc ttcaatcgct tggtgaagcc cctcactgta gcggcggcct ttcatcagac 2900461 gtcccgtgaa ggaatcaaca ataacaacct gtccgtcttc cactacatag tcaacgtcct 2900521 tttgcatcgc aacgtgagct tttaaggcct ggttgatatg gtggttgagc gcgacatgct 2900581 tcacatcaaa gaggttatcg atgccgaatg ctttttccgc cttcgtcatt ccttcttcag 2900641 taagctgtac agcttttgtt ttgatatcgt acgtgtaatc cttctccgct tttaacgtgc 2900701 ggacaaaagc atttgcctgt acgtacagct tagtggattt tgcagcttgt ccagaaatga 2900761 taagcggtgt tcttgcttca tcaattaaaa tagagtcaac ttcatctatt accgcaaaat 2900821 gaagcgggcg ctgaaccatc tgctctttat aaagaaccat attgtcacgc aaatagtcga 2900881 agccaagctc gttgtttgtg gagtaagtaa tatcagcggc ataagcttcc cgtttttcgt 2900941 cttttgacat tgagtttaaa ttcaaaccga cagtcaaacc gagaaactcg aaaattttcc 2901001 ccatttgctc agcgtcacgg cttgccaagt attcgttgac agtcacgacg tgtacgcctt 2901061 taccggttaa cgcatttaaa taaacaggca gggtagacgt taatgttttc ccttcccctg 2901121 ttttcatttc cgctatattt ccgtcatgaa gcgccacgcc ccccatgagc tggactttaa 2901181 acggaaacat gcctgttacg cggcgtgaag cttctcgaac aacagcgaaa gcttcaacaa 2901241 gaagatcatc cgttgtcgcc cctttttcaa gacgctcttt aaattcaatt gttttatgtt 2901301 tcaatgcgtc gtcagagaga ttttcatagt ctccgcgaat cgcatcaata tcgttagcaa 2901361 ttttttcgta tctattcagc gtacgttttg ttggatcaaa cattttattt aaaattccaa 2901421 gcatttataa cgctcctcta tcatcacacg cctattttag aggcatgtat aaataattta 2901481 ctagtccatg tatacctctc attatcatat catacctttt gttatttcca aagaatttgc 2901541 aaataagaaa aacaaaaacc ttccgcggac atcacggaag gcttctcttc attattcagt 2901601 cggttcaatt aagccatatt tcccgtcatt tctgcggtac acgacatttg taaggtttgt 2901661 ttccgcattt gtgaaaacaa agaaattatg gccgagcata ttcatttgca agatcgcttc 2901721 ttcactatcc atcggcttta aattaaagcg tttctgacgg acgatgtcca agctctcctc 2901781 ctcttctatg tcatcctgaa ccgcaatatc tgtatcagag ccaagaccgt ttgccaataa 2901841 atattttgga gagccctgct cacggaattt acggtttact ttcgttttat gcttacggat 2901901 ttgacgttcc agtttgtttg ttgcgagatc aattgcgttg tacatatcct cgttatgcac 2901961 ctcggaccga agcgccagat ctgtcatcgg aatcgtaacc tcaaccttag actccttgtc 2902021 attgtaaaac ttcaagttga cgttcacatc agcatccacg ctatggtcaa aatagcgctc 2902081 cagcttgccg atcttcctct cgacatgatc ctttaacgcg ggtgtcactt caatattttc 2902141 tcctctgatg ttatagttca tcaaagaacg cctccctttt attaaggata tgtatctatt 2902201 tctcttttac cctttacaat tcctgctgaa acataaatct tttgtgaaaa ttcagtgaac 2902261 tttgtcgaat tttgtttgta tttgctctgt tattggcggc tgctaagctt ttgaatcaaa 2902321 cagtttcatt ttgctacttt tcggcagctc agctttaatt gatttgctgt aattgaagtt 2902381 attttcctta ggaaccagca tatcgtacga aatagagatg aattgcagcg cgtctcttgt 2902441 cagctgccta ttcatctcat ttactttttt cagacgtccg agaacttgag aaagagattc 2902501 gtatagttgt tccagctctt ccttttcact gcctgaggtt ttggcgatac atgcggaaat 2902561 agtattattt tcgctatatc cgagaaaggc cgaagttgtt ttgatccggt catcttctgt 2902621 ctgcgtgatt gcttgaatat atttttgctc ttttgtcaaa atgttagaaa gctcttttgt 2902681 tttgccggct ttgagcgctt ccgtcttttc ttcagacagc gtgagcaggt gctcatgcag 2902741 aacgcaaagt cgcttcaatt gttcaataat tgccttcgct gacatgggct ttctcctttt 2902801 ttattgcttt ttataaaaat taatcatatt tttcgcaata tgatttgcgt ctactttgta 2902861 tgacccgttt tcaatttgcg ctttaagctg cgcaattttt tcctgtcgtg aaccagtgac 2902921 tgcgtcggat gcatgttgca tttctttagc ctgtgatgaa atttcaattt tatcttgagg 2902981 ttgtgcaaca gttttttgca ccgcttgctt atcataattt ttttgatatg gattaacgga 2903041 ttgtgttcca aattgattga ttttcatagg attcctctcg ctttccgttg cagtctttaa 2903101 acaatcttaa cccttttatc gactgcgttt tcagttagtt tagggaatca gctgtttttg 2903161 gtattatagg catagtatgt gtctttttta ctattttctt tctcgatttt cagagcatcc 2903221 tcgtggttca aatgatccat ttgatcctta atatcagact ggcaagcctt gcagaacttg 2903281 ccttctctaa tcgatgtccc gcacctttca caagggtatg ccaaattagg aagatgagtg 2903341 atctgaattc gcttctgcct gatgaatttc aatatcagct cttcttccac acctgtttcc 2903401 tcagttatcc ggctcaaagt tgattgccgg ttttcctgtt ttcttaaaaa tttatagaca 2903461 gtctcaaatg atttttcttc ttccttaata cacgcctgac atacggtttg cagctttgtt 2903521 tttaaaaata aagcattgca tttcggacaa ttagccagtt ctcccatctt tttttctcct 2903581 tattagataa tatgcctgtg tcaatttcta gtgattatat cggcataaaa acagaatcat 2903641 ttagcttctg atcaaggtaa aagatgacac tgaagcggct tttccttttt ctaataagca 2903701 gcgggctgcg aagtgcaagg tggcgcctgt tgtataaaga tcgtctatta aaatgatatt 2903761 cataccttct gctgaattat tttttgtatc aaaaatgcac tctgacagca ggcgttctgt 2903821 tttctttttc tttgactgtt tctcattatt caggcgaatg aggggatggt gggaaggccg 2903881 gtctaaacat tctgccaaga gatgtgcctg gttaaatccg cgctcttctt cccgttcctt 2903941 gctcagcgga ataggtacaa gaacaaaatg cttatcgggg taaaccttag aaaaggttga 2904001 agaaaaatca cttttaaatg catttatgat ttctgcatct cctctaaatt taaaacggga 2904061 gagcgtttct ttcatcatat cattatatgt gtaaactgaa cggttttgac gcaatagcaa 2904121 actgtctctg atccttgttc tccacacctc gcaatccctg catacggcat gaacagattg 2904181 aggtctgccg cacagggggc agatatgtcc tgtgattttc tttaatttgc ttctgcaaga 2904241 ataacaaacc ttttcatcag gctttagtaa aaaaagggct ctccatgtaa catcttgaga 2904301 aaattgcgaa tcacataata aacagatcag tttatgaatg cctcctcctg cttcgtttga 2904361 cataaatcgc ttggactctc tgaaactact gcagcagatt cagccaaaat gacaagcatt 2904421 gctgtgtttt tttgtttatc taccagctca gctttcgtat atgcgatctt tttaaaatca 2904481 gtaacgtagg atggactcac tttgtttaaa gaaagtgcca atacatcgtt ttggcatact 2904541 tggcaagtac aggccatatg aagctggtcc atatatcggt cgagcagttc tttcattacg 2904601 atttcttttg aattgacaag catttttaca gctcctcatc atcggttata tgagtatact 2904661 gtaccacgtt ttcaaataat ggctagtctg tacattcaac ttttgctgcc aattcattca 2904721 tttcttttat atgctttctt gcatcgagca tactctttgt tttgccgaag tgaaagtaaa 2904781 tgacatcgcc gtccgcatat tctttatgcc ggccggttct tcctgcaatt tgaacaagtg 2904841 cgctttccgt aaagatagac gattccgctc ctagtacacc cgtttgcacc ttggggactg 2904901 tgacgcctct ttccagtatt gttgttgtga ttaatagatc gagctgacca tctctgaatt 2904961 gctgcacttt ctcctttcta tgcttgtctt ccgcgtgcac agatgcggtt cggcaatgaa 2905021 cacctttaaa gcacgcagca gccttttcca gaatagaaac ggaaggaacg aataaaaaaa 2905081 caggcctccc ttcttttaca tgaaactcta tccatctttt caccgctggc ggaattttat 2905141 ttcggtttaa tttcttcttc cagtttccac accatacaaa gcgcggttcg ggtaaaggtt 2905201 tccggtggtg tcttgcgggg atgcgaactg aatgtaactg tccgttcagt gcttttcttt 2905261 ttaattcttt aggaggtgtt gcacttaaat aaacgagggt gctgtttttc tttcttgctt 2905321 tttgaacagc gaattgaagg gtttgatcag cagaatatgg aaaagcgtca acttcatcaa 2905381 tgatcataac atcgattgca tctttatatc gcaaaagctg atgcgtagtg gaaatcataa 2905441 gcggagatag ccgccctttg tcatcgcttc ctccgtaaag cgctgaaatg tcagcaccct 2905501 gaaaggcagc cttgagtctt ggagcaagct ctaatacaac atcggtgcga ggtgttgcaa 2905561 tacatacacg cagtccttga tttaacgctg attctatacc aggaaacagc atttctgttt 2905621 tgccagcgcc gcaaaccgcc cagatgagga gctcttcttt ttttgatatt gcttcaatta 2905681 aaacattggc ggctttttgc tgtccgcttg aaagcttgcc atcccatgtc agcttaatag 2905741 acttccagtt tgattcattt tcctctttcc atgaatataa aggaacctcc tcactcactc 2905801 tgcccatcat gacacaggaa cggcaataca gcttattctt tccagatgag tgataaaaag 2905861 aaaaataccg ctgatcagtt tgtccgcacc tattacatct atatctccgt ttatttatgg 2905921 atatagaatt ttcagcagtg atatatccat tcttgatatg ccattcaatc atctcatcgg 2905981 aaaatgagag ctcagtcctg agcaaatgac ggcttcgaag cgtctgctgc aattcttttg 2906041 aaaaggaact gtttttttca actggcacat tcacatagca cgcctccttt cgaaacagta 2906101 tgcctgaatg aatattttct gtccaactat taaaataaga atataaaaaa atctccgctc 2906161 taaaaacgga gatttggcct tatttaaaac accagcaaat tcctaacgca ccttcaccca 2906221 aatgagtgcc gattaccgcg ccaaaatagc tgttataaaa ttcaacatga ggatattttg 2906281 cagaaagctc ttcaatgatt ttcgctgctt cttcctctcg attagcgtgg ataacagcag 2906341 ctcgcatagg caacccttta ctcgcatctt cgtctaaaag ctcataaatt cgcgaaattg 2906401 cttttttacg tgtgcgaatc ttctcaaaag gcacaattac cttattgtca aaatgaagga 2906461 taggctttac ctttagaaga ctaccaatga aggcttgggc gctgcttaat cgcccgccgc 2906521 gctgaagatg ggctaagtca tctaccataa aataagctcg aactgttttt ttcatttctt 2906581 ccagttcttt tataatatct tccggcgatg atgctccgtt tttgattaat tcagcagctt 2906641 taagggcata aaagccttga gccaagcagc tgatctctga gtcaaatgga tacacatcaa 2906701 tattgtcgac catcgaatca gccgctgctg cactgctgaa tgttccgctg atcccgctgg 2906761 aaagatggat actgataacc gcatcataag acttgccaag ctcttcatac aacgcaacca 2906821 gctcgccgat tggcggctga gaagtcgtcg ggagctcatt atgttttttc acttcttcat 2906881 aaaagctttt ccagtccaac tcaatttctt cacggtaagt ctcctcccta aaaacaacct 2906941 ggagagggat catatgtatc tgatgttgtt cacgcatttc tttcggaata tatgccgtgc 2907001 tgtctgttac gactgcaata ttcatagctt cgatacctgc cttattgctt tataactcta 2907061 ttgtaaggga aacggcagcc taaaaaaaga cctgcctagt aaaaggcaag tctcctatta 2907121 tactatctca tttctaccca gccattttta atggcgacca caacggcttg cgtccggtcg 2907181 tttacattca ttttttgtaa aatattgctg acatggtttt taacggtttt ctcactgata 2907241 aacaatgatt caccaatacc gcggttgctt tttccgtctg caagcatctg cagcacttca 2907301 cattcccgcc tagttaaaat atgtaatggt ctgcggattt cagggtaaac ctcatgttga 2907361 gggtgtgcag aaactccgct tgttgcaagg cggcggaatt cgttaacgag gttgtgagta 2907421 accttcggat ggaggtaaga tccgccctca gccactactt taaccgcttc aattaatgta 2907481 tcagcatcca tctctttcag cagataacct cttgcacctg ttttcagggc atgtgttaca 2907541 taattttcgt catcgtgaat tgatagaata attactttag attcaggata cagctctaca 2907601 agctgttttg tagcttccac accatttacg tttggcatat tgatatccat gatcacaaca 2907661 tcaggatgat agtgctcaac aatacgagcc gcttcgtccc cgtcatcacc ttcggctacc 2907721 acttcaaagg taggttcaaa atccaatatc cgtttaacac cttcacgaaa taactgatgg 2907781 tcgtcgataa taacaatgtt tactttagtc acaagccacg cctccttgta ttattgttct 2907841 atatactcta gcattcggtc aatatgcctt ttggctctat tttacaaatc atagtcaaag 2907901 agataacgga accttaatca taataaatgt cccaagacct attttcgaat ctattgtcat 2907961 cgttccttcc aataaatcta ctctttcttt catgcccagc aagccgaatg atttgttttt 2908021 cttctctttc gcttccttca ggtcgaaccc tttaccgtta tcttttatca ttaaaatcac 2908081 aaaatccttt gtgatctcaa ctttgactgt aatttcttca gattcagaat gctttagcgc 2908141 attagacaca gcttcctgtg cgagcctgaa gagcgcaacc tcaaactgag gcgctagcct 2908201 ctgatcctct gtttctccaa tgcactgaaa atgtattttg accttcccgt tatattcctc 2908261 ggttgtatat agatattttc ttaaagttgg aatcaggcct aggtcatcaa gggccatcgg 2908321 tcttaaatca tatataatcc ttctcacttc gtaaagggca ttccgaacat tttggcggag 2908381 atttttaatt tcttggaatc cgtcctctgc gccccggtca cggaaaatcc gctcgattaa 2908441 ttccgatctc atcataacat tcgccagcat ttgagcgggt ccgtcatgga tttctcttga 2908501 gactcttttt cgctcttctt cctgcgcctc aataattctt aagccgaaat cctgttttgc 2908561 ctgagcatca gcaagaagca gtccaacttc gcgcaaatcc tgattcaagt agttgagcac 2908621 aactgtaatt tggcttacta atgattctga ccgctcaatg atttcctgaa gccctagcaa 2908681 tctgcgctcc aaatcgtccc gccgttcgcg caattgcttc tcacgctgct ggatcatcgt 2908741 caattctacc tgcagcttat gggctttttc ataagcattg cggatttcct cttcactgaa 2908801 tctatgaaaa ttacggctga cctcggataa acggtttctc gcatggcgag tttgcacttc 2908861 aagtttatcg ccaagctcaa tcacttcata cacctgctgt ttaatttgtt tcagttcttc 2908921 gaccagctgt tcatactgct ggcgtgactg ctccccgatt tgaaaaacct cgtccttgct 2908981 cccgtcaacg gttttcagca tcttcatcaa aatagaatcc agcactttgg aatccatctt 2909041 tgttttattc ataatttccc tccgtcacgg cgttgtcata tatttttatt ataaatgtaa 2909101 ttgatctgca aattatgtcg aattataatg aaagaatgcg tatattctag aaaaaaacat 2909161 ttttatatac tatctactct ttatgatacc aaaatacgca caaaaattct aaagactgta 2909221 cgaatttgta taggcagtct tttatgctta gcaggagggt cagctagcat gctgcacagc 2909281 tattttactg tgaaagaagc gggagaacac gagattgtta tagaaaaatc gcgttttatc 2909341 tgtcatttaa gccgtgtttc taccgaacaa gaggcacagg aatttataca gaaaataaag 2909401 aaacagcact ggaatgcgac tcataattgc tcggcttatg ttattggcga gaatgatcat 2909461 atccaaaaag ccaatgatga cggggaacca agcggtacag cgggagtgcc gatgctcgag 2909521 gttttaaaaa aacgcaggct gaaggatact tgcgccgtcg ttacacgcta cttcggaggc 2909581 attaagcttg gtgctggcgg attaattcgc gcttatggga aatcagtgtc tgaaggatta 2909641 aatcatatag gtgttgtaga acggaagctt atgcgaatca tgcatacttc tgcagattac 2909701 acatggcttg gcaagattga aaatgaatta agggagtcac aatttctgtt aaaggaaatc 2909761 cattattcag aaaatgttga attcgaaaca tacgtggaag aaaaagaaac caacgctttt 2909821 tctgaatgga tgacagaact gacaaatgga aagagtgata ttaaagaggg agagttgacg 2909881 tatcttgaaa aagccgtcaa tcacataaag gagactgaat aatggctgaa cgcgttagag 2909941 tgcgtgtgcg aaaaaagaaa aagagcaaac gtaggaaaat tttaaaaaga ataatgttat 2910001 tgttcgccct tgcactattg gtagttgtag ggcttggcgg gtataaactt tataaaacca 2910061 ttaacgctgc ggatgaatcg tacgatgccc tatcccgcgg gaataaatca aatcttcgca 2910121 acgaagttgt agacatgaag aaaaaaccat tttctatttt atttatggga atagaggatt 2910181 acgcgactaa aggacaaaaa gggagatcag actctcttat tgttgttacc ctggatccca 2910241 aaaataaaac catgaaaatg ctgagcattc cgcgtgacac acgtgtgcaa ttagctggtg 2910301 acacaacggg aagcaagacg aagatcaatg ccgcttacag caaaggcggt aaagatgaaa 2910361 cagttgaaac tgttgaaaac ttcttgcaaa tcccgatcga taaatatgtc acagttgatt 2910421 ttgacggatt taaagatgtg attaatgaag tcggcggtat tgatgttgac gtgcctttcg 2910481 atttcgatga aaaaagtgat gtagacgaaa gcaaacggat ttacttcaaa aaaggcgaga 2910541 tgcatttgaa cggcgaagaa gccttagcat atgcccggat gagaaaacag gataaacgcg 2910601 gagactttgg ccgtaatgac agacaaaaac aaatcttaaa cgcgctgatt gaccgcatgt 2910661 caagtgcaag caacattgct aaaattgata aaatcgcaga aaaagccagc gaaaacgttg 2910721 aaaccaatat tcgcattact gaaggtttag cgcttcagca gatttacagc ggctttacca 2910781 gcaaaaaaat cgacacattg agcattacag gttctgattt gtatttaggg cctaacaaca 2910841 catattactt tgaacctgat gctacaaatc tcgagaaagt cagaaaaacg cttcaagagc 2910901 atttagatta tactcctgat acaagcactg gcacttccgg taccgaagac gggactgaca 2910961 gctcaagcag ttctggcagc actggcagca ctggcacaac aactgacggg acgacgaacg 2911021 gaagcagcta ttcgaatgac agcagcacaa gctcaaacaa cagtacaacg aattcaacaa 2911081 ctgattcatc ctattaaaaa atgcccggtc cttttagagg atcgggcatt tttgcgcaga 2911141 aaaaaactcc ggcacataag ccggagtttt taattccttt tcaccagccg tttataaaac 2911201 tttgtaaacg gcttaaattt ttcattcacg agtcctgtca cttctgctat gatttgcata 2911261 aaaataatca aaatgaagat aataaacaaa gaaagccaaa ttgtggcact tttaagtaca 2911321 atcgcactga tactgaaaat aaatccaatt aaataaataa ctaagaccga catccgatgt 2911381 gaaaggccaa aggccatcag tctatggtga atatgcgact tatcaggcgc tgaaatcggc 2911441 tgtttgttta atattcttct gatgatagca aatgttgtat caaaaatcgg tacgcctaat 2911501 ataataatcg ggataacgat actgaacaat gtgacacttt tatacaggcc taataatgaa 2911561 agaatcgaga tactataccc taaaaacagt gatcccgtat ctcccataaa gatttttgcc 2911621 ggatggaagt tgtaaaacaa aaaccccagc gtgctggcaa taacgactaa tgagagtgac 2911681 agaatgagca cttttccgcc ggatagcgcc atgacagcaa tcgttgacag gccgataaca 2911741 gaaagaccgg cagcaaggcc atccaatcca tcaatcaggt taattgcgtt cgtgatgccg 2911801 acaatccata ataccgtcag cggataagcc atccatccta actcaaatcg ttctgttaaa 2911861 aaaggtactg agaaaaagtc catttttaag ccagtgctta caatcataat ggctacacct 2911921 aattgaatca aaaacttaac ttttgcactt aattgatatt tatcgtcaag aatacctaac 2911981 acaataatga tgaatgctcc gactgtaatt gccgtcatcc ttgtttctgt gtaaataccg 2912041 gatgcaagca cgcctgcaac caccccgata aatatggcca gcccgcccat gcggggcatg 2912101 attttgtcat gtacttttcg attgctgggc tggtcaactg cacctatttt aatcgcaatc 2912161 ctttttacga ttggggttat gattaaaact gtcagcagcg agacaataaa cgcaacaaca 2912221 atgcgaatca tgcgttcgtc aagcataaag aagtctcctt tggaattaaa tgaagtcttt 2912281 atttatatag agaaccgttc cttccattat accttctcct tagttattat aacaagcttc 2912341 atcaaaaaga aacacgtata atcaaaaaac gcgcatccca atttatagga ctacgcatgt 2912401 ttttgaatcc ctgtatattt cataatttgt ctaaataagc aattccaatc ttgtgtccgg 2912461 gcgatgtttc ggcgcatttc tttataggtc tcgtctccgt tttgaccgag aactttttca 2912521 caagcggcta taaaatcaat cggatgatcg ccctctacat attcgtatac atacggcttt 2912581 tgcatttttg aggttgacgg aagattagtg cctacaacag gttttcctgc cgctaaaaat 2912641 tcaaatagtt tcagcggaaa cacagcttga ttatacggtg attgtttata tggcataatg 2912701 ccaatgtcga taagctccat ataatgaggc acttcttttg gatctgccgg accggtccat 2912761 atgacattgg gaagcctcag cagctcttga aacgaaacat caccattggt ggcatccggg 2912821 ccaacccata aaaatgtcca atcaggcttt tgcagtgccg cttctttaat cattttaaaa 2912881 tcgagcttcg gtttaatccc gccaataaaa cctaacacta ttccttctct cccctgcagt 2912941 atactgcgat cgggagcttg tttatttgca gaaaacagct catactccac accgttttcc 2913001 acagtatgaa ccttttctcg tcctgcagtc agttttttgt ctacttcctt gtgaagataa 2913061 tctgatgaac aggttattga atctgctcgt tgtataattc tcagctctgc cgatttaatg 2913121 acttttcgcc ggaattcaga cagcagattt gatcggccgc tgatcggcgc agcccatagg 2913181 tcactgcagt cataaatgac ctgatcccaa gaatacagcg aagacagcag cgggaatccg 2913241 ggaaacgtgt accataaaca gcagcgttca ccgtttgcag aagcaggtgt aagctcatcg 2913301 agtaatgggg agagcttatg tctgtaaaag acatctgtat atcgtccgaa acgaaacatt 2913361 tttttctgca gcaggtcttt gacagcgaat tgcctgatgc cagaatggac ttcctgaaac 2913421 tctttccctt gggcacgcgg agccggacat acccaaataa cttccttcgt ttcctcctga 2913481 gcagctaaaa attctgccag ccggtgcctt ctgtatctca attggtcttt tccccattca 2913541 gcagtggcaa cgatgacatg aatgattgct tcttttgttt ccaccttcat caccttttct 2913601 ctctgtttgc agctataatc tttttttcac cgcgtttttt gcatattgaa caaaacacca 2913661 tgttgctttc ataaaatgaa gccgttcgat ctccctgtag acaaaccacg tttttttcgc 2913721 agccttccat ttgttgctgg aaattgaatt attgacaagc cgatattcag ccaggcattc 2913781 attcattcca taggcagtaa atcctttttt taaaagagac agccatgtgg ctaagtcctg 2913841 tctcgttctg atattcggca tttggatctg tcccgtttgc tccctgtcaa tcatcaccgt 2913901 caagcagccg ataattgtat ttttcagggc gtcatcgtac gtcaggcttt ccggcgcatg 2913961 aataaattta tcgagcgggg tcccgtcctg cgccattaag ctgtagcccg tgaaagagaa 2914021 cgcacaggag cgctccatca taaactcaag ctgcttttcc agtttgtctt ttttccattt 2914081 gtcatcactg tccaaaaatg ctacgtagcg cccttgagcg cgttccaacg ctttgttgcg 2914141 agcaaccgca gctccggagt tctcttccag atacaccaca tgaattcttt cgtctatttt 2914201 ttcatactgc tgtaaaatgt cgcgggtccc atccgttgag caatcatcca cgataatcat 2914261 ttcccaatga ggatggctct gatctaatac cgaatgaacc gtgtcttcaa tatagtcacg 2914321 cgcattatag gaaggtgtaa tgacagatac gagaggtttc caattggtca tgatcacatc 2914381 tccatcgtat gattttaaaa ggattctctg aaaaattcag gaatgacaac gaacataaag 2914441 gcaatcgtaa ggccaatcat aacgccgaga actgctttct ttttcggaga cataccgccg 2914501 cctgctgtct cacttacggt ttcggaatca gtaacacttg ccgctttcag gttaagctgt 2914561 gtgtttttga gttcatataa aaatctctct ttatccactt tggaatcctc gctcaccgac 2914621 tcgccttcaa gcgcgtctat gctgctgcgg atgacggctt ctctttctgc atacagcttt 2914681 tgatcgtttt tgaggaaggt ggaggatatg gcgtttaaga cagattccgt tctatcctta 2914741 tcctcgtcac tatagcttaa agtcagtaac gatttggatt ccgtattgat tgtaagcttc 2914801 tctttgatct ctgctacatc ttcatccttt tcatcaggaa gcgcctcctt caaaaaggag 2914861 tcgctcttta atagaagcgg aatctcttct gtgctgttat aaaccggatg atcatagctc 2914921 cccacagcca aagtatcttc agctgtatag ctcttttgat cagcgatctg tgacggcagg 2914981 atataccccg ccgcacctaa tataattggc accgctatga tccaaatgat attttttttt 2915041 atgcgacggg ctattcttat caatatatcg ttcatataag tctccctgct ttttgtagtc 2915101 tgtttatctg tacatcggct caggcatttg tctggatcgc cttaacacat tcacggcggc 2915161 gatgacgagc gccataaaca cccaatggaa aaataaattt gaaacagagc ttgggctgat 2915221 acttgatacc aggaaactga ccatagcggt aataagtcct tctgtgatca gttttgactg 2915281 attttctaat tttctttcat aaaacttgta aagcacccat atgaggtagg cataaacgga 2915341 caaatatccc agcatgatga acaaaccaaa attagcaaga atttcaacaa gccagttatg 2915401 cacctctgcc acattgtcag tatcatatac agcataatgc tcaagataat aggatacatt 2915461 tcctgccccg actccgaatc cgtatgaatc aaggaaaaaa tgccaagcgt ttttcagcag 2915521 atttgcccga gccacatttg atggaagcct gtcatgaaat gaatgcagcg tctgcggggc 2915581 cagaaacagc tcccaaaact ttgaatagat tttgctggcg aaaagaactg cgaaaagagc 2915641 aattcccgcc gccgacagcc atatagccat tctctttaaa acaggcggca atacaatgaa 2915701 gatgtagaca gcaatacctg caaaaatgcc cagaaggctg gctcttgaac cagtggcaaa 2915761 aattaaatac aacgcacaga gcgagagcac aaggccaatt gccttgatgt atccattctt 2915821 aatgtttttc atcatcgtga tgtaaaaaaa gaagctgatg gataaaaagg tcgcaaagtc 2915881 attttgatta aaaaagaccg atgtcggata atgctgcttg tactccggtc cgctgtacaa 2915941 tgtggaactc gcaagatgat ggtgggtgat atgattgtaa aaaccaatga tcatcagaaa 2916001 taccgtcatc accagccaaa tggcataaac aatcatcagc cgctccattt tttgcacgta 2916061 catgacaata agataaatga agaagatccc cattgccaat aaggctaaat acttgaggcc 2916121 aactgttacc gacttggccc acagcagaga aacaaggcca tatataaacc aaaaggcgaa 2916181 aaagagtaaa atccctttta cttgcagccc atgccatctt tcaatatggg ttcgattccg 2916241 aaccatgccg aaaatatgaa ggcaacccgc tgcaatgagc agaagccggt aaaggaacaa 2916301 actgaaaaat ccaagatgaa tggcaaaaaa tgcattattt aaaaaagtgc aggcgatcaa 2916361 aatatagatt acagccataa agagccgttc ttttgttgta aatgcggttg caagcgtcag 2916421 taaaaacagg ccaattgcca acaccgcaag cacagcagcc atctgcatga aacctatatc 2916481 tttatggatg gctcccagca ataggacgac tccaaatata gcagcggcca gtaacgctag 2916541 cgtatggacc gctgatcgtt tgatactcac atgtttaacc cctttcctga tgtttcagga 2916601 gccggcggcc gagcctagca gccggcagct tcaaccaagt aacacttttt ctttttataa 2916661 attgacgctt cccaagtctt tagccaattc ttcaagcggc aagcccggaa aatacttgtc 2916721 agagggttcc gttccccgaa cagcgggacg gccgatagag tgataaatgt atccggctgc 2916781 ctgcatctct tcaagtgaaa ataaatttct gccgtcaatg atgactggct gttttaagag 2916841 ggttttcact tttacaagct ccatttcttt cacttccggc caatccgtta aaatcaggca 2916901 tgcatcagtg tcttccatcg cagcatacac atctgtgtaa tactcgacct gttcgccaag 2916961 gatcgctgaa gcttcaggaa tagcaatcgg atcgtatgct tttacatggg cgcccagctg 2917021 ctgcagcatt gggataatat caagcgctgg agcggatctc acatcgttcg tattcggttt 2917081 gaaggctaat cccaggactg aaatggttct ccctttgacg cttcccataa cagtcaaaag 2917141 tttatctaca atatgaacac gctgcttttc gttcgtttca atgacagctt cgatgagctt 2917201 gaatggatag cctgccgatt ttgcgatttg aagcagcgcg gttgtatcct ttggaaaaca 2917261 tgaaccgccg aatccaatac cagctttaag gaactttctg ccgatacggc tgtcaagacc 2917321 aacaccatca gcaacttttg aaacgtctgc gccgactcgc tcacaaatgt ttgcgatatc 2917381 gttgataaag gaaatctttg tcgccagaaa tgcattcgcg gcgtatttaa tcatttctgc 2917441 actttctagg tttgttttaa tgacaggagc atggaatggc tgatgaagtt cctcaatgat 2917501 ggcagcggct ttatgacttg ttgaaccaat cacggcacgc tccatattca tcgtgtcatg 2917561 aatcgctgac ccttcccgaa ggaattcagg gttagataca acatcaaatg agtatctccc 2917621 ctttgaggct ttttgaacga tagattgcac cagtttccct gttccaaccg ggactgtgct 2917681 tttatttacg atcactttgt agccgttaag atgctcaccg attgttttcg ccgccgcttt 2917741 gacgtacgtt aaatcagctt cacctgtttt ggacataggc gttccgactg caatataaat 2917801 aatatctgag gcccgaatgg cagacgggat atcgttcgta aaggtcaggc gctgatccag 2917861 cacatttttt tcaactaagt ctgcaagccc tggttcatag attgggatta ccccattttt 2917921 caggcttctg atttttgatt catcgatatc acagcaaaca actttattgc cgatctccgc 2917981 aaagcaagtg cctgatacga gtcctacata acctgttcca atgacagcta tttttttcac 2918041 agcgctcaac cctctcctgt aaaatgatct tccaatttat aatggtcgca gtgtcttacg 2918101 attaaacgga cgttttcgtg accgtctgat actgatgatg caaggccttg gcgttttttc 2918161 ctgcgtcaaa ttgagcctgc acggtttcat acaagtcatc tgctacttcc ggcttccata 2918221 tttgctcatg ttcgtaccga gtgatcgctt ccgccaaggc ttgagcggat ttcggtttaa 2918281 tcagcagatg ttggtgcttt ccgaataaag acgacactcc gccaacatcc gtacaaataa 2918341 caggaaccct tagcgccagc gcctcaatca caacagtcgg catcccctca ctgtaagaag 2918401 gaagtacgaa tagatctgcc gcaagtaaat agtctcttac ctgatgattc gggacttggc 2918461 ctgtgacgat atgccccttc tgcgtcagcg tcgattttgc gggaccatcc ccgacaaaga 2918521 ctgccttagg agagtcctgc agcgattcga tcgcttcaga cagttcaaaa atgcctttct 2918581 ctctgaccag ccggccgaca tagacagcca gacgctgatc gagcgggagt ccgagtcttt 2918641 ttctgatttc ctctttcgtc tcctcattcc cctgaaaacg gctgagctgt atgccgattg 2918701 gcaaaaccga gctgtcaaag cccgaaagct ttttggcttc ttcctgaagc ttgtggctga 2918761 ctgctaaaac aactgacgca gaacctacgg cacgcttgaa ggctttaaac gcacctttgc 2918821 tgtaatgcgg atagacattc acatcactgc catgcaaggt caggacataa ggaatttgcg 2918881 ctgactctga cacgactgcc gcagccccgc ccgatggcat ggcaaaatgc gcatggatca 2918941 gatccggata taggtcgcgc tgtttcattg tttttaaaac ggctgatgcg attctccgat 2919001 gaggctgcgc ccacttcagc tggccgggaa ctgcccgata gaaaggccgg taaaccggta 2919061 tcccctttct aatctcatac tccggtctga catccttttt tcgatatgtc tttttcagca 2919121 tgcggacagg tgctgaatga aaaggccgtg ggcatatcac agtgatatca agcccgagtt 2919181 tttgcagctc ttgcacctgt gtctcatgaa acacaccctc tccgggtttc atactgctcg 2919241 gatatacgct tgtgatccac aaaatcttca tgacaaacgt ccttttctta gtagtttgct 2919301 tttcgtttga gggtacgctt ttaccaaaag aaagagatag cacagcgccc cagccgcaac 2919361 tgaaatggcc agccgcattt ctgcctgcat actgaagtgt tcggtactga ggcttacacc 2919421 aaacgcgatg atgcccatcg ccgcagtaat cagaaatggc ttcataatcg actggaaata 2919481 agctgaaagg ttaagcttga tgacatatgc caaaagccag cgcccaatca ggaaattaac 2919541 aacgctgata atggcataca cccatgcgac tgtcagcagg cttcccgtct gtacagctgc 2919601 aaacagtgat aatccgtaca gcagcagcac gccggaatcc caataaaacg ctaagtcagc 2919661 tcttccttta gccagcaaca cagatccatt tggattcatg agcactctta gtattccgac 2919721 aatcgcaaga acatttagga tcggaacagc agcaagccat ttttctccga aaaccgctgt 2919781 gataaaggcg tctgacacag acacgagccc gattaacagc ggaaacgaaa caagcgccag 2919841 catttttgtc atattcagaa agccttctct gatcacgctg ttttcatatt tgttttttgc 2919901 gaaaataggg aatgccaccc gtgtgacaat cggattgatc ttcaaaaccg gaatggtgac 2919961 aatctgataa gcgaggttat aaatccccaa tgcttcagca ccaataaacc ggccgatcaa 2920021 aatcatgtcg atatttgctc ccagcctgtt cacaagacgg gatgaaagct gaaaggctcc 2920081 aaaagaaaag aaatccttca tgcctctcaa atcaaaaaca aaagcaggat gccacttttt 2920141 tcggtataca gcccaatata aaatcccttt actggactgc agcaggactt gagaaatcac 2920201 gtacgccaaa atcgcatcca tcataaaaac cgctatcgct aaatatccga atgacaatac 2920261 atttgaaaaa atctctattt tgcttaacgt attaaaatgc agctgctttt gcagcatata 2920321 ctgatattgc tgtccaattg gcgcgatcaa aaacataatc gccagaatcc gaaccagaaa 2920381 caccagctct tctctttgat aaaatcccgc aatgacagga ctgctcacat ataaaagaac 2920441 aaacagcaaa acgcccgtca taatgttaag ccaatacaat gttgacagct ggcgctccgt 2920501 cgcgtcgtct ctctgaatta atgctgcgcc aaaacccata tcgagcacaa tctgggcgaa 2920561 aactgtaacc gttgtgatca tgccgacaag cccaaattct gttaaggtca tcatatttcc 2920621 aagcagggca aactgaacaa tttgtatgat tgtaatacac atggttgaaa tacttgtcca 2920681 ctttgcaccg ctcatgattt gttttgtaat acttggcatc atattcccta cttcttttta 2920741 agctcagatt gatggtgaat aatggaatcc cgttttatct tgcaccatca cccgtccaaa 2920801 ctactttaca agtttttaac ataattttta attctaaagt gaaagtcaga ttgcgaatgt 2920861 aatataaatc aaatatcagc ttttccttcg gcgtcatatc gtaaccgccg ttcacctgag 2920921 cccagacgct gtgtaaagcc tggaatctca ttctggaatt tttccgtaaa tacgggccgt 2920981 tccggacgag ggccaatcat actcatatcg cctttcagca cattaaacag ctgaggaagc 2921041 tcgtcaattc tcgttcttct gataaaagct ccgatccttg tcacccgcgg atcttgcttc 2921101 tgtgcccaaa ccgccccaga cttctcggca tctattttca tggaacgaag cttataaagc 2921161 ttaaatggct tcccgccttt ccctacgcgt tcctgcgtat aaatggcagg ccccggcgtc 2921221 tccaaacaaa tcaaaattga aaataccgca atcattggca gcgcaatcgc caatccaatg 2921281 agcgcaaacc aaatatccat tacgcgcttt attgccaaat aacgagccgt cttttcagat 2921341 aatgtaaaag aatgtatttg ttgaactgag aattcacgac tcacattcat gcttttctct 2921401 gcactcactg acacacacct cacgatttgt ttgggatgtt atgatgacct atgccagtca 2921461 gtttagcaga cggatgttaa ttggatgtaa atggtatgtt aagaagtgtg aattacgtgt 2921521 tttttctgat aaatgttgtt aatactcttt tactatttta tatacaagtc ctatttgttt 2921581 taatcatttc atataaaaaa gagacaaatc tgtgattaga tttgtctctt tcgattatct 2921641 gtaataagat actgtgccgt catgaatagc ttgtgcagct ttatctttat aaaccgcttg 2921701 cttcaattta cttgcatctg atgcattagt gataaaggca gtttcaacta aaacactcgg 2921761 cattttagaa tatttaataa catagaaagc agctgttttt actccccggt ctctcgttcc 2921821 aagattagcc gctaactttg gttgaatttg ttcagccagt ctcttgctat ttgcagcttg 2921881 atatgttgta tcgtagtacg tctcacttcc atttggtgat gagctatcat tagcatttgc 2921941 atgtatactg agaaataaat ctgcttgtgc agaagctgct ttatttactc tctcctgtaa 2922001 agaataaaaa gtatcattag atcttgacag tactggaaga gcacctgaag catttagctt 2922061 tgtattgact cttttcgcta tatcaaggtt gacttctttc tcaaggagtc cattgccgat 2922121 tgctcctgaa tcttgatcac cgtgacccgg atcaataaag attgtttcac ctacaactgg 2922181 attctttagc tgattagcaa cctttgtgct tacggcagga gtgtttccga taatcataaa 2922241 gtttgacatg tttttacttc caataatttt acgggctcct gtagataaat tttcaccatt 2922301 tgtaagaata agagattgct tcttcttagc tgccagtgta gctcctgcaa tagagtcagg 2922361 gtagctgaat ccattgctta catatacggt gcttgttgat aaattaagtt tttgtacgat 2922421 atttgcagca agctcatatc tgtttgaacc gctaattctt gtaggagaag gtaacttgtt 2922481 gtataccgta ttgctgatac ttccagtgcc tcctacaaca acggtactcg aaattccctt 2922541 atcttttatc acagacgtag tcgcactatt tatagatgtt ttatttgtaa aaagaattgg 2922601 atacccgttt ttcgctgcat aagggatgac ggccggagcg tctgcatata agaagccgtt 2922661 caaaataaca gcttttgaag tcgcacccat cgcttttgcc acccgtgcag ccgtatcata 2922721 acggttgctt cctgcaattc gtttaatact tatccccaag cttttaatct ggttagcagt 2922781 gttagaagaa acagcaggtg ttccgcctac aataattaca tttttagtct gcatctcttt 2922841 caatcttgtt ttcgtttcat atgaaagctt atcagaatta gtgtaaagca atggcgcatt 2922901 cttctggtaa gcaagaggtg ctgctgaaat agcatctgca taggaactcc caccaacaat 2922961 tacagctgta cttgctgttg aatacatttg ctttgatatt tgtacagcag tgccgtatct 2923021 attgcttccc ccaactcttt tcactgagtt atcggccaaa gctgttggca caaaaagtat 2923081 gagccccaga aaacacattg ttaggacttt tatataagaa cgcaattgat ttcctcctta 2923141 aatggcgtta tatcctaaaa taatcaataa cttgtcagag ttgtacctgg atagtaaaat 2923201 ttcaaaattg aactatatga atctccagct tctgctcttg cttttgctcc atattgactc 2923261 attccgatcc cgtgaccata tcctttaccg ctgattgtgt actttgaagt atcttttttt 2923321 acagtcacat aagtactttt aaatacagtc gctccaatca ttgttcttaa ctcacttgtt 2923381 ggtacactaa tggttgtaat tttgctcaag ttataggagc cagtactgct tttaacaaaa 2923441 tacttcactt tcatcgatgc tgtttttgca cgctgccctt gtgtcgttcc actaaagctt 2923501 aaatcgtcaa tacttgcaat tttgacagaa tcagcgcttg tttctttatt tttcaagatc 2923561 cagttcttaa ctccggaaag tcttgcagaa tcagtttcag tcgctgaaga ccaccaagaa 2923621 gaaggcttcg ttaagtccaa agatttcgta tctagctgtt gttttgacaa agtaagcgtc 2923681 cagcctattt gaggatcctt tgtatctttt tttgcaatca agtaaggtac acttgacgac 2923741 cacacttcat tactagcttc tgtgtaacca ccattactgg aagaataagc tgcagttata 2923801 agagatccat tatatttcag aactttcccc ttcgtttgct ctaccgcttt attggtattc 2923861 gaattccaac tgtagccacc ataaacttga aaagcggttg tatcaggtac agtagttcct 2923921 gtttttgtta ttgagtaggt tcttgcagcg acagtctgtg ctttaagagc ctcaagtgac 2923981 cagctagcag gcatttcatt cggaattact ccttttaagt aatcctcaaa tggaatattc 2924041 tcatttaccg gtcggatata tttagtagac tcaatagaga aattaaccgt gccaagatac 2924101 tgctttccat caagactaat tctgtttgaa gtagaatagt tttctggttt aattcttagg 2924161 gagtttccgt aagttttgat gttttcaagg tttaattttc cgctgttgat ttttagatta 2924221 taggtgccac cgtcagctaa ataaaattca tcagcaagtg aattctcaac ttcagcagaa 2924281 attgaactgg tacttccaat aaagtcgtat gcatatgtgg ctttatcttt cgttatactt 2924341 ttagccgcag ccggaacgct atcttgttta acaaataaaa tttggctgtt tttcttcgag 2924401 gcaagcgaag cgcctatcaa tacgtctgca tattttgtcc cgttcgtcat tacgacttta 2924461 tcagccttca actttagttg cttaattata tttgccgtaa gttcatatct ggttgatcca 2924521 ggaatccttt gcacagttga agttttttta atttggtttt ctacactatc actgacgcta 2924581 aatgaactgc ctataatgat gacttgtttt ggcaaatcat aatccggaag cttgtctttc 2924641 tctgtaagca aaatagggta tccgtgtgct gctgcatatg gagcaatggc taaagcgtct 2924701 tgaaatactc ttccggttac aacgatcgct ttatcatagc tgcccatttg ctttgcaata 2924761 ttttctgata agacatatct attttttccg cttatccttt tcacagcgcc atatgatttc 2924821 agcttgtttt ctacgtcttt tgaaatgctt cgcgctcccc caatgattaa aatattatca 2924881 gggttaaact tagcaatttg tctttcagta gtttttgtta acgtgtcagg ctgagtaaat 2924941 aaaactggtg cgttcagttt tttcgccaat ggaataacag gcaatgcatc aataaaaata 2925001 tctcggttca ccaatatcac tgtattagga tttttccact ggctgttgga tgcaagagtc 2925061 gcagtttcgt atcgtgaagc gcctgcaaaa cgatccgtaa cagcaacatt atctccagtt 2925121 actttataaa atcctgttgg cgatagactg atgctagatt tatttccaat ataatttaac 2925181 aatttaactg agatgtttga gtctgctgca aaagaaactg atggaatcaa taataagatt 2925241 gcagcaagtg aacacactat caattgtttg caagatttca aaatttcagg ttcctcccta 2925301 tatcttagtt ggcacgttca atatctttta acagaagctg accctcatca tttttttcat 2925361 atgtaatcgt gaccttatct ccactgttaa acttatcaag atcacttgtc gattcttcag 2925421 tgatatcaag actaaccggc tcattatcta ctgttacttc tattgtatga gtatcagcta 2925481 accctacata agtaccttct tttgtttcaa tgttactgtc tggcgataca tcttcacctt 2925541 gactcttttg actattaacc ccgcaacccg aaagaagcaa tataaagaac agtaaagcaa 2925601 taaatttttt catttttttc acctcattat attttatcgt caacctattt tatattttaa 2925661 agaaaaatta agaaacaatg aaactttttt ttataaaaaa cgactatttt aggatttcat 2925721 tcttgtatta aatagagttg tatttattgg aaatttaact cataatgaaa gtaatttaac 2925781 agacgaggtg caaaggatga gaaacgaacg cagaaaaaag aaaaaaactt tattactgac 2925841 aattttaacg ataatcggac ttcttgtact cggaactggc ggctatgcat actacttatg 2925901 gcataaagca gcttcaaccg tggcaagtat tcatgaaagc attgataaat ctaaaaagag 2925961 ggataaagag gtcagtatca ataaaaaaga tcctttttcc gtcttaatca tgggtgtgga 2926021 tgaacgcgac ggcgataagg gccgtgccga tacgctcatt tatatgaccg ttaacccaaa 2926081 aacgaataca accgacatgg tcagcattcc gcgtgacacg tatacaaaaa ttatcggaaa 2926141 aggcacaatg gataaaatca accattcata cgctttcggc ggcacacaga tgacggtaga 2926201 cactgttgag aacttcctcg atgttccggt tgattatttt gtgaaagtga acatggaaag 2926261 ctttagagac gttgttgata cacttggcgg cattacagtt aacagcacat tcgcgttcag 2926321 ttatgacggt tattcgttcg gcaaaggaga aatcacgctg aacggaaaag aagcgctcgc 2926381 ttatacccgg atgagaaaag aagatccgag aggcgacttc ggacgccagg accgccagcg 2926441 ccaagtcatc caaggtatta ttaataaagg cgctaatatt tcttccatca cgaaattcgg 2926501 agatatgttt aaagttgttg aaaataatgt gaaaacgaac ttgaccttcg ataacatgtg 2926561 ggatatccag tccgattaca aaggtgcgcg gaaacatatt aaacagcacg aactaaaagg 2926621 tacaggcacg aaaatcaatg gaatttacta ctaccaagct gatgaaagcg ccctttccga 2926681 tattacaaaa gagctgaagg aaagcctcga aaagtaaaac aaaaagaagc ttcgcacaat 2926741 gtgcaaagct tcttttttat ttgcctgtaa atgaatccgg ttgttctttt cgatacccgt 2926801 aatgaaacag caattcttcc acaatccggc gggaagcctc tccatctcca tacggattag 2926861 aagcctggga cattttcttg tactcatcag gatcagttaa cagctgtttt gcaagctgat 2926921 aaatgttttc ctcatccgta cctgcaagtt tcagcgttcc cgcttccact ccttcaggcc 2926981 gttccgtcgt atcacgcaga acaagaaccg gtttcccgag agatggggct tcctcctgca 2927041 cgccgcccga atcggtcaat ataaaatgcg atttcgctgc aaagttatgg aaatcgatca 2927101 cctctaaagg ttcaatcaga tgcactctgt cagaatcacc aaaatgctta tgagccgctt 2927161 cccggacaac aggattcagg tgcacagggt aaacgacttg tacatcttca aattccccta 2927221 caattctgcg gatggcctta aacatgtttt ccattggctc acccaaattt tcccggcggt 2927281 gagcggtcaa gagaatcatt ttatcctcac ccacctgatc gagaacagga tgtgagtaac 2927341 catccctaac cgttgtgttg agtgcgtcaa tcgctgtatt gcccgttaca aaaatagagt 2927401 cggccttttt gttttctttt aataaattgt ctttcgcctg gcctgtcgga gcaaaatgca 2927461 aatcagcaat cgcccctgtc atctgtcgat tgagctcttc cggaaacggg gaatacttat 2927521 tccctgtacg gagccccgcc tccacatgac cgacagcaat ttgatggtaa aaagcggcta 2927581 ggcttccggc aaacgtcgtc gtcgtatcac catggacaag cacaatatcg ggtttgatat 2927641 ctttaaacaa ctcatccaat cttacaagtg cgttagacgt aatctctgcc agtgtctgcc 2927701 gctccttcat aatgttcaaa tcgaagtcag gcttgatgtg aaacgcatct aacacctgat 2927761 cgagcatctg tctgtgctgt gcagttaccg ttacatagga atctatttca ggatattttt 2927821 tcaattcaag cacaagcggt gccatcttga tcgcttcagg cctggtcccg aaaacggtca 2927881 tcacttttag ttttttcata tttgtcacct ggttttctgc tatagtaaat aaattcatac 2927941 tacatattct acatgaaaat gcatcatttt aaatcatttc attcttgatt caaataaaat 2928001 gatataagtt ttaatattaa ggataaagct tgtttaaaaa tggtttatcc gatatcataa 2928061 aaatgtgtaa aaacatattg aaaagggtaa atagagaata gtttaaccat aaattttttc 2928121 gatcataagg aaggtgcctt ttaaatgaaa aaagtacgta aagccataat tccagcagca 2928181 ggcttaggaa cacgttttct tccggctacg aaagcaatgc cgaaagaaat gcttcctatc 2928241 gttgataaac ctaccattca atacataatt gaagaagctg ttgaagccgg tattgaagat 2928301 attattatcg taacaggaaa aagcaagcgt gcgattgagg atcattttga ttactctcct 2928361 gagcttgaaa gaaacctaga agaaaaagga aaaactgagc tgcttgaaaa agtgaaaaag 2928421 gcttctaacc tggctgacat tcactatatc cgccaaaaag aacctaaagg tctcggacat 2928481 gctgtctggt gcgcacgcaa ctttatcggc gatgagccgt ttgcggtact gcttggtgac 2928541 gatattgttc aggctgaaac tccagggttg cgccaattaa tggatgaata tgaaaaaaca 2928601 ctttcttcta ttatcggtgt tcagcaggtg cccgaagaag aaacacaccg ctacggcatt 2928661 attgacccgc tgacaagtga aggccgccgt tatcaggtga aaaacttcgt tgaaaaaccg 2928721 cctaaaggca cagcaccttc taatcttgcc atcttaggcc gttacgtatt cacgcctgag 2928781 atcttcatgt atttagaaga gcagcaggtt ggcgccggcg gagaaattca gctcacagac 2928841 gccattcaaa agctgaatga aattcaaaga gtgtttgctt acgattttga aggcaagcgt 2928901 tatgatgttg gtgaaaagct cggctttatc acaacaactc ttgaatttgc gatgcaggat 2928961 aaagagcttc gcgatcagct cgttccattt atggaaggtt tactaaacaa agaagaaatc 2929021 taaacaaaaa ggctattgga cattcatcca atagcctttt tttatttcaa catcaaagtc 2929081 aatgtatgct cttcattatc aactgcgaag acctgatcaa cggcctgccg caaaaattaa 2929141 taatcccaga caaacacact gattgtagag ttaaacaaac taaatgaaaa cataaataca 2929201 aacatgcaga ttaaatagta aatatcttgt attcaatgca agctaagtaa acaccacttg 2929261 ctaaaagaac aatgactaaa caaccagcat tacaaaataa ttaaataaat ttgaagcaat 2929321 tacaacagaa ggcagtgaac tgtcggaaag ttcattttgg ctaccatatt aatcccttta 2929381 actacgctgt tggatttatc aagaattgtc gggctaatag aaaaccacgg aatcaaacca 2929441 gccagcattc aaacgataaa aggcacttct ccgatacctg ttatgaccag cttactgttg 2929501 cgcatcccaa atacaaacca gtacgccatc attagaataa ggggatttaa aacctgccat 2929561 aatacaccaa aataattgat tttttggatc tttcggttaa agaaatttaa aagtaccagt 2929621 gaatattgta acaaatgttg agtttttttc acttttaaaa agtaaagaga agtctcgcag 2929681 aacttctccc aacatttgaa gtgtcaatat aaaacaaacc aacctcattt agcaacttta 2929741 ttattatcta attccaaaat agcattataa atacgattcc tattattttt atcagtatat 2929801 gcaaaaaagt tatctactct ttttctatac ttatcttcca tacgactatt gtttttcata 2929861 taatagataa ctttatccac taagctatta tgattttcta atacatcacc aaaccccatt 2929921 tttttataat cataataatc aagtttaaaa tggtatgact tttcgtattg ataataaata 2929981 acaggttttt tctcatatgc aaaatcaaac gcaacagatg aaaaatcagt aatcattata 2930041 ttagaagaat taaatagcat ttgatagctg ctgttatagt cggcaaactc cacataatca 2930101 tgcttttcaa agtctacaat ctgttgctga atatctgggt gaggaaaaaa agttatttta 2930161 taattatttt tcttagcaaa ttcgattagc cgttcatcat taatcaaagc attataccta 2930221 gaaaaatatt cactatcttt aaatttcggg ttgtacggtc ttactccttt tgcctgatct 2930281 ttcggtaata caatatcttt tctccaagtc ggcattatta gaagttgctt ttctccctca 2930341 ctcttcttaa gattatcgta tctcggaaat ccacccaaca aaatattctc ttttttatag 2930401 ttgtaattcc ctttcacaat agaccgatat tcaggtttgg cagaagtgac taataatttg 2930461 atattcttgt tgtatttgtt taaccattca gaatgatctg ccattgttat tccgtgctgt 2930521 aaaaagataa actcaaagtt aaataaatct ctaaaataaa tctccatatt aaaaaatgga 2930581 tttacaaccc atatatctgc atgtgtcgat attactttgg aagaggataa ggttaaaatt 2930641 ttatgtctaa aagatctgta tggtatgacc tttccatatt ttttgattct gtcgtaatcc 2930701 ttgctatctt tttttattat aaagtatttt tttaccccat cattcttgtt gattgcatat 2930761 ttaaagaggt gctcggcatt atcatcagct ttgtcttgtc tgtctatgaa taaccatact 2930821 ggttttctat taaaaatagt gaaaacatgg tgtaccattc ttgccatcag tgccttctta 2930881 atcgctgatt ttcgtttttt tgatttttcc cctgatttat gtagggattt taagaaacga 2930941 aactctttta taaatctatt tttaaaattg ttttttttga acattaattt tttataatta 2931001 taataaaaaa tataatcttt tttagccaca taagtattat ataaatcgtt tgacaaacct 2931061 gaatacttga aaaaacgaag ttttgtcaac ttcctttttt tacccttagt tataaaaaac 2931121 tcaatatgat gattatctgc tagatgacct ttgggaatat ctattgaaaa accgggatat 2931181 ttttttatta cttctcctaa acttatataa tcattatgct gtctttttat attctttgct 2931241 tttatttttg tttcgccaat tttagcataa aacttaaaac ctttagaatt aaacagcgag 2931301 ctccaaaagc cttctatgtg aatggaatcc tcattttctt ctaaaatttc aatagttaaa 2931361 gtttgatccg ataatttcga aacaatttta ccttctctgt ataaataata atcctgttca 2931421 gtttctcttt catatacata cctactataa ttttcaccgt gctttatttt taaagcatga 2931481 tataaataga aatggctgac actttttgtt tcaatgatga catcgtcgtc aatatacgac 2931541 aatacttctc gaatcaatgt taaaaattca ctgtattcat tttcgtctaa aggtgtttca 2931601 ctgatatcct taatcaataa tttccacttc aaatcatgca taaccatata ttgaagaaat 2931661 aaaggtattt tctgttcatg attttttata atatcgatta aattctttga gaaagtgata 2931721 agtgaatggt taaaccaatt cttatttgct ttagcagtct gcatggcaga tgatccatct 2931781 tctctaactc tataatggta ttttgcctct ttaaccagac catacttttt cttttgcgat 2931841 atgattaaat taactagttt ggcatcttca cctattttac aattttcatc aaacctgata 2931901 tttttcaagg catctttttt tataaatgta gaacaacaat gagttaatat atgatgcggt 2931961 tctttttcta catccaaaat tcttgtagaa gaaaacttat tatttagatt atgttctcca 2932021 gttcttcctt ctgcaaaaaa aatagggatt gctacaatat caatttcatt cttatgttcg 2932081 tcaaagaagt ttaaaacatt ttcgaatgtt ccttctgaaa ctaaatcatc cggatccaaa 2932141 aattgaatat atctaccttc agcatacttt aaaccataat ttcgagcact gctcactccg 2932201 ccattctgtt tctttgcata gacaatgtta ttgggatatt tctgagcata ttctttacaa 2932261 atgatttcac ttttatcggg gctatcatca ttcaccagta ttaactgaat attctcaaaa 2932321 ccaatagttt ggttaatgat actttctata gcttcagtga gatacaactc aacattataa 2932381 atcggcatta taacactgaa atcatagtta aaactttttt cgttcataaa agattactcc 2932441 taacataatg tttatatgaa taagaattcg ggtaaataaa attaagaaac aagagagtac 2932501 taatttttgc aaaacaattt taatttagta aaatgtatga aaagcattcc ttaccttttt 2932561 ttaaaaaccc ttgtaagcaa acttttaaaa atgttcacat ggttaagttc taaagaatca 2932621 tttggtgttt ttagtacaaa gtcaaatgca aaggcccaaa tcggtatttc gacaacaaaa 2932681 ccagcatatc taaaatctct taatttatat ccccatactt caattgtttt tttcagttct 2932741 tttcgtttgc atttttttaa tcttttaaaa tattttatat atattctgtc attttctttc 2932801 atctcataat actggttaat aaagtgccct gttaattcaa gtctaagccc ttttattttt 2932861 gccgaagtaa cagtacatga actatgcagt actctttctt tttttatatt ttcaagagct 2932921 tctgtatttt cttttaataa gtgaaacata aattctttat agtacatcgg catatcttgt 2932981 tcttttataa attgcgggtc aataaatttt aaaactttaa taaaatcatc aacaaaaact 2933041 ctttgttctt gttgatctaa aacagactta taaacatctc tatagttcgg atataaaaac 2933101 agttttatat gatatacaat taaaaattgc aaataaggca aaactatatc atatttgttg 2933161 aatgaatcca tcaacaaagt catgtaacat tcattcaaca aatatgtgta cctttttttg 2933221 ttaaaccatg aacgatcaac taaagaatcc tgttctttcc gttttctata aaaatacttt 2933281 ccttctgcaa ctgctccgta tcttttttct ttcagtaata actggttaaa aaagatagcg 2933341 tcttcccaaa actttataga ttcatcaaaa aggacggtac tagttagtgt atgtcttctg 2933401 taaaaagtgc cgccaatata aaaatgaata gctttataat cgttgagaat atttataact 2933461 cttgttcctt tttcaaatct attatttaat ttatgtcccc cttctttttc acctgtgtaa 2933521 taaacaggta ataccgcaat atttacatgt tcggaatcac aaaaaaaatc ataaacactt 2933581 tgcagcgcat tttgagagaa tgcatcgtca gaatcaagaa aaccaataaa tttagatctt 2933641 tcgcttacat ttgataatcc acaatttctt gcagcagaag gtccagagtt ttcaattttc 2933701 atgattttaa tattattagg atatagattt ttaaaggatt cacaaatttg aggactgctg 2933761 tcaacactac catcatctat taatatcagt tctatatttt ccttaaatcc aattgactgg 2933821 ttaaggacac tctctattga atatcttaaa taattttcag aattatatat tggtataatt 2933881 atagaaaaca tgtttgtacc tctttattta gaagttaaag gatcgtttca attactcttt 2933941 tagaagcctt gcctcttcta aattacaaaa tttattataa aaatcctcat agttatgatc 2934001 tatataagga ttatgtaaca actcttttac cgtatctata agttcttcac ttgtttgaag 2934061 caagtttcct ggcgtttttt gctgaaaatt aaagtaaaaa cctctgatac agtctctata 2934121 agccgggaga tcatacacaa aaaatacaag gtttttttaa aaattcatat tatcaaaaaa 2934181 gacagaagaa taatccataa tcaataaatc actaattaaa tataaatctc gaatatcttt 2934241 atttaaagaa acatcgttca caaaatattt atatttccct aattaaattg ttctgaaact 2934301 ggataatacc attcttacaa gaataaccat agagtctcca aggttccctc ttcatttcct 2934361 ctaatcaaat taaagttaaa tttatactgg ccagctttct taaaattcat tatcccgcaa 2934421 agttggtgca tataaaatta tttttcttta attccttatt tgataatgta gaattggtag 2934481 gggattgtag ctaaactgtt tccagaatag ctttcaaata aaattaattt attgtttctt 2934541 ggcagaagga caaaaatttt aaacaaaact gaataaactc taactagtaa acttctgcaa 2934601 ttggttataa taaaaatttc atcagtgaac tccttaaaga gtgaagatta atatttacgc 2934661 aaacaagaaa aaaagaagca actgaattta cttcaagcct cttttagtta gtgcttctat 2934721 aaactagcca tatcttttct gatttgggta gttgaaatgc ctgctattct tgtaaggtaa 2934781 atggcctcat agtattcctt tgtagacaat cgtacgatta agtaatccca ggttcttttg 2934841 ctctttccag tagcttcata tgtccatagt gaaataaatc aaacattccg tacgtatcac 2934901 tttcttcatt agataacatc accttccaac cttttccaac ttagaaaaaa caaaaatcct 2934961 taactgattg tttatcattt cgacatattt tttacgttcc attaataata aacaataata 2935021 gcatatgttc ctataaaagt taaggctctt taaaaatgta aatcatcagc actttttgac 2935081 aatatcgttg cattgatgtg tattttttac agatctgata tcttatctat actcattaca 2935141 acaagttttc tattccggaa gagtcaattc tttttgtcgc gttttcaagt gtaatgattt 2935201 tctttctgct gcgtcattta ttttgtacgc cctcctcata ttacttcatc gtcaaaacgt 2935261 gaaggaattg taatacgtag ttcctaaaaa ttttcgtggt aaaatttagt gaagtcttta 2935321 tcaggctaag ggactttatc taaactacga attacatatg gagatatata gatgaaaagg 2935381 agggttgata tgatataaac gaaaatcaat tagataaagg aaaaactgaa cacttctgaa 2935441 aaaagtgata agtttctttc actatatcct ccaaaaagaa cctaaaggtc ttggacatgc 2935501 tgtctggttc gcgcctaact ttatcggcga tgagccgttt gcgtttctgc ttggagacga 2935561 tattgttcag gctgacacac cagggttgcg ccaattaacg gatgaatatg aaagaacact 2935621 ttcttctatt atcggtgttc agcaagtgcc tgaagatgaa acacactgtt atggcatcat 2935681 cgccccgctg acaagtgaag gccgccgtta tcaggtgaaa aacttcattg aaaaaccgcc 2935741 taaagacaca gcaccttcta atcttgccat cttaggccgt tacgtattca cgcctgagat 2935801 tttcatgtat ttagaggagc agcaggttgg cgccggcgga gaaattcagc ttacagacgc 2935861 cattcaaaaa ctgaatgaaa ttcaaagagt gtttgcttac gattttgaag gcaagcgtta 2935921 tgatgttggt gaaaagctcg gcttcatcac aacaactctt gaatttgcga tgcaggataa 2935981 agagcttcgc gatcagctcg ttccatttat ggaaggttta ctaaacaaag aagaaatcta 2936041 aacaaaaagg ctattggaca ttcatccaat agcctttttt tatttcaaca tcaaagtcag 2936101 tgtatgctct tcattatcaa ctgcaaaaac ctgatcatct gtattcacaa gaaaacgctt 2936161 cttgctgctg tcatacaata catcgctatc acttaaggat agtgacgccg ggttgatagg 2936221 agaaatgtta tgaaaaataa gctctgttgc tttatcattc tccagtacat aactgatttt 2936281 ttcataatca aaattcagcg tttttctgcc gtcagcctta tttccttcag tataaccatt 2936341 caatttcgat tgaatgctgg tgctgctgtc tcctaggaat ttcagaaagt attcatagga 2936401 agatgctgcg ttttgcgaga cataagacgt aaatgcagtg gcatgcaatt cagcgtgttt 2936461 catgttagtt gcaacagcgc tctgtttcac ataataagag tgcccgtcaa actttatttt 2936521 cgctgcttgt ttgccttttg cagctaccgt tacttttgta ccgaatggca gtgtaacgtc 2936581 agccttctgt ttcaaaccct gatccttata agcagccgct ttttcatttg ctataaaccc 2936641 ttgcttattg attgcagtta agcgttcctc tgacttgccc tttgcatcgc catgatggtt 2936701 cttcacttca ttttgcggaa tagcgccaaa cgaagcaatt gtacgaagcg gggcattaaa 2936761 gaacatcgtt cccgccatga agacagtcag aatagacaaa atagcaattt gaatggcatt 2936821 ggccagtgat ttcggctttt tcttcttttt gcggaaacgg gcaaacgctt caggatcttc 2936881 tttcttcctc tcttctgtct gctctttttt atatgtctct ttttcttttt tcgatagctt 2936941 attaaaccag tcaataaacg ctttgtactc tttcacaacc gtttttgttt catcaaacat 2937001 acgaagctcg ccatagtgca tccaagcaac acggtcacac atcttttcaa tctgaccgat 2937061 tgagtggctg acaaagaaaa tcgtttttcc ttgcttttta aactcattta ttctgtctac 2937121 acacttctga taaaacgttt ggtcccccac agaaagagct tcgtcaataa ttaaaatgtc 2937181 aggatcaata tgcacggaga tcgcgaaacc gagacgcgac ttcatcccgc tggaatagtt 2937241 tttaaccggc tgattaataa aatcgccaat ctcggcaaat tcaacgatgc tgtcatacat 2937301 atcatcaatt tctttattgg ttaaccccat catcaaacac ttgagccgga cattgtcccg 2937361 gcccgttaat tggttattca aaccggcagc aatcgcaatc agcgacggct ggccgttcat 2937421 ttcaatttca ccgctggtcg gcggaataat tttagccagc aggttagaca tggtcgattt 2937481 tcctgacccg tttattccta caaagccgat tgtctcccct tcatacacgt caaaggagac 2937541 attccgcaca gcaaaaaaac cattatcctt agccggaaaa aacaatcctt taatcttgtc 2937601 cgattgtttt ttatacaaat gatactgctt tgaaacattt cgaaacgaaa cttttagttt 2937661 catcgtaaaa tctccttacg tattaaagaa agtcaacaaa cttgtctctg aatttcatat 2937721 gcaggataga acctactaac aataaaagga atgtgaacaa ccaaaagtac agcgtgtact 2937781 tcatgtcatg gaaaaaccat gctccatcta agaagctgtt ccggaatcct tcaataatat 2937841 agaatagtgg attcaacttc agaacaggca ctaattcggg gtggctttga ccgagtttcg 2937901 cattaacatc ccaaaaaatt ggcaacaaga aaaacaaaag tcttgttacg gcctgcagca 2937961 aaaattgata atctctaatc agcacactga tcgttgagtt aaacaaacta aacgaaaaca 2938021 taaaagcaat catacagatg aagtaataaa tatattgtaa ccaatgcaca ctcgggaaca 2938081 caccattaac taggagtaca atgatataaa tcaccatcat gatcatataa ctaaataagt 2938141 tagatgcaat tgccacggac ggtagagaac taatcgggaa gttcatttta gccaccatat 2938201 taatgcgctt aaatacacta tttgatccat caagtatagt tggactgatg aaaaaccatg 2938261 ggattaatcc tgccagcatc caaataataa aaggcacttc gcccgctccg gttgtcacag 2938321 gaccgccctt tctaatcccc ataccaaata cgaaccagta ggccagcatt tggataagcg 2938381 gatttaagaa ctgccataag acacctaaat aattcatttg atatttagac ttggtttcat 2938441 aagccgccaa tcttaaaatt aaaggaaatg acgttatttg ctctctgagt atacgcaaca 2938501 aatcattcat tttttatctt ccttagactt aattgttttt gggaatcttt ctgtttaaaa 2938561 tttgaaagca ccgctgatta ttgtaacaga tcctgcattt tttttcactt ctcaacaagt 2938621 atctaaaaag ctgccgaaaa atcgacagct atacatttta taaaataacc taaattattc 2938681 agctttaaat acagtattaa caaccttttc agatgaacgt cctgactcta aatagcaaaa 2938741 cttatcatag aaaggaccaa aagaaaccgg aagcttataa tcaggcgatg agatctgctt 2938801 gatagcctca atcgtttctt cagtagtttt taccaaagga ccaggagctt ctttttcaaa 2938861 atcaaagtag aaaccacgca acttgtcccg gtaggtttcg atgtcaggga caaagaatag 2938921 cattggccgt tttaaatttg caaaatcaaa gaatactgaa gaataatcag taatcagcaa 2938981 atcagaaacc atatacaatt ctcgaatatc ctcataagca gaaaaatcat atgcaaatcc 2939041 ttcaaaagga cctaaatcaa aattctcagc taccagataa tgcattctta agattacaat 2939101 atattcattt ccaagttctt gtctaagttg atgcaaatct aaatcgagat cgaacttata 2939161 acgccctttt gcatagaact gatcatctct ccatgtaggg gcatataaaa taaccttttt 2939221 atcacgagga atatttaacc tactctttat caatgatatt gtttcctcat tattatcatt 2939281 atgaagaaaa tcatttctag gatatccaga ttcaatcatt gtcttgttaa actgaaacgc 2939341 ccgtgtaaag atctcagttg aataaccatt tggggaaatc aagtaatccc aattagaagc 2939401 ttccttgata aaattccttt tatatttttt ggtgtttgta ccaggcatat ggacttcttc 2939461 catatccatt gcaagtcttt ttaaaggtgt gccatgccat gtttgtaaat atgttgtatg 2939521 actaggtttc ggaatccata atggaagccg gctgttaaca acccaatact cagctcttgc 2939581 catagcgaag agccatttta atgagaggcg attaatgtaa ggaattccct tttcatcaaa 2939641 aggcgctgaa tattgtttat ttacactcca atacatttta tactcagggt ggttttcccg 2939701 catatattcg taaatcgctc tcggattaca actgtattgt ttcccattaa aactttcaaa 2939761 aatgactgtt ttccttttaa ctggcattct gctagccatc atgaatagag atttgtatgt 2939821 tttagtgatt aacttgtttc tcatttttgt gatctttttt atttttgata ctaatctctt 2939881 cttctttcct ttaataaagt atttcatcct tgttttcagg ctatagtcgt ttactctgat 2939941 acctagagtc tgctttttct ttttcttaaa gacttcataa cgaactggtg cgttgtttgt 2940001 tttaataata cttactaatc cttttaattt gttttttcga tctcctaaaa caagagcagt 2940061 gctgttgaac tgaatatccg ttccttcatc gtcattgcat atatactcca taaaaagacg 2940121 ataaacataa cgtttttcat ttgagaaagg aatttctttc aaaggcactt tcacttcaaa 2940181 atcatacagt tccggaacaa aaccatctgc tctcatgttt tccaggccat gtgtttttct 2940241 ttctagcttg attggaaatt tttcctcaat aggtgtttct ccaccctttt ttaaaataag 2940301 gttcaagttt tttatccgat attgattttc ggaactcagg taccccgcat aacctgttat 2940361 gcttatttct tcagagctaa tctcgatttg atcaaatctg atgattttgg cctctctttt 2940421 caccttaata gaaaagttgc ctttatcagt tgtataaggt aaaatcaaaa gttctgtggt 2940481 ttgatcgaca tgaaaggcgc gctcaattga atttacttca gcagaaagac gcttcaagag 2940541 tggttcctgc tccgcatctt catatttttt tcgaaattcg acataaaaat catatgtttg 2940601 tcccatttca acaggcatag gcaaaacatg agcatttatc tcagttttat actctaatga 2940661 gccagtgttt tgaagcggaa attcagattc cgttcctgaa cgtctctctt tcagctttaa 2940721 aaataactgg taatcctcta aaaattggtg ttctgaatca attgagatta acaattcaag 2940781 acttcctaaa ttgtttttca agcttttcaa aatacattta atcacagtgt tttcaatcat 2940841 tacttttttc tgctcctctg tataaaagct ctttcctttt tgcttccttt tattagtgtc 2940901 aactactaag gacattaact ctcttttatt tccgtgaccc tccaagagaa attgccttta 2940961 actgttgtat agggctctac tctatagcca ttattagtat ctatactgtt tcctgacaat 2941021 tttgtttctt cactcgaaag tcttcgcatt gttttaatat ggccatttgc attgaaaaca 2941081 atataaaaat caataacttg ggttttatta gcagctatct tttcaatatt tacatctttt 2941141 tcgagatcaa ttacaaacag ttgatcattt tgtaagtttg ttgaaataat ttcagcctta 2941201 ttctttctgt ccaagcccac taaacgtatt tttttaatat cattatgatc aaaattctca 2941261 atgtcaattt ctattttagt tttatcaaaa tcctcagtat aggaactaat agaaggatct 2941321 ttttttccaa cctttttaga gaacttctct ctttctattc gcacctcaat catctgatta 2941381 agagcaaaag cccaattttc aatatagttg ggtcttgaat atttttcagc cattttaaaa 2941441 gcttgttctg aaaatttttg atgagtactt tcatctttca tcaaagagat aatagcttga 2941501 cccaatttct ctatattata ctgttcaatg acatatccat ttgctccgtc agtaactaag 2941561 ctccttgctc cgtaatcata atcgtatgtt acaactggac atccattgct cagtgcctcc 2941621 atatttgata gaccgaaccc ttcaaaatga gaggttgaaa tggttagcca agctttttga 2941681 aactctgagt cagggttatc cgtatagcct ttcaaaaaga cattgttctg cagtttggta 2941741 tcttcaattt ctttttttat tttttcgaaa tcttcacccg atccgaatat atcaagtttt 2941801 gcttcaggaa tttctttcac gactaaacta aatgctttta ctgcatgtat cagatttttc 2941861 atagatgcaa gtcttgaaat aatgacagct ttgtattttt cactcggcac attcaataca 2941921 gcgggatcaa gaggcttatc aattgtatgc ggagtaaaga aaaacgtctc ttgttcccct 2941981 gaaatcaatt taaaatcttc tagctgctcc tcagttataa aaaagacagc atccaaatta 2942041 tacatctgac taaatacttc tttatagcga cccttaattt gatatttatt gctgccgtaa 2942101 tgcttgttat gaataattgc tccataatag gaagaaggtg attttttcac tttaaagaca 2942161 tgtttgtctt gcggtctgct gtccactaaa aacaacttag gtttatcatt ttgtttttgc 2942221 agatattcta tccaatattg acgcagttcc gattcatctt ttacttttat ctcaccctca 2942281 agggagtacc aaataatatg agataattga acatcttttt cttcattgtt ccatacatag 2942341 agtttgtcta aatatacttg attttggtca ttaatatatt cctgcagata catcttgttt 2942401 agctgcacat cataatgagt aacgagaact aagtttccgt tcttcgtata ttcctctctc 2942461 tttatgagct ggtttttatc attccaatag tcgacgtacc ggatagtttc tccatctccg 2942521 tagtaaacta cagacatttc attgttcttc ttaccaaaca atctcaacag agtttttgca 2942581 aatttcccca ttccaacttg cttttttatc tggtcaaggc ctatcctttc ttcgtatgat 2942641 cttttcccat ttgttctaac acttaaaaaa tcatcgaata gattaataac acttgtgaat 2942701 tttttatcaa tcttaccgtt gctgtacaat tcatcaattt ttgaagacaa ctctaaatca 2942761 aaacgaaacg ttaagaaaaa ggtgttttgg ttacactctt ctccaaataa ttttgaacgc 2942821 aataataatg atttcgtcag accgccataa ttacttggca gtccaccaga gataaaataa 2942881 taatccatgt caggaatttg ttttatatta gattcactca ccgcatgtaa agacaatttt 2942941 ttactccctt tcggcatcta gaatatatga tcattgaaat ttatatctac ccggatactt 2943001 tagtcacaaa aatcaatgta agcatcaaaa agtacttctt atttcaataa gaagtacttt 2943061 aattagatat tgaaccaatg atatcaggat cctaaattat aaaccagcaa tttcctcttt 2943121 gatctttgtt gtagagatgc cttctgttct tgggaggtaa acaacctcac actgatcttt 2943181 gagaaagtca aatttacctt cccagtcatc ccccataaca aaaacatcaa tattatgatc 2943241 aataatatct tgcttttttt gctcccaatt cttttcagga attacttcgt ccacatatcg 2943301 aatggtttct aaaattaatt tacggtgctc atagctgtga taagcttttt tttgcttttg 2943361 taaattgaat tcatccgttg aaatagcaac aactaaataa tcaccaagct gctttgcacg 2943421 ctcaagcaat ttaatgtgac cccaatgcag taaatcaaaa gttccatatg tgataacttt 2943481 tttcatttaa agaaacgctc cttcctaatg ttaaacacta ttaaaaacac tactgacgtt 2943541 agcgattaaa ttctaaaaac ctgtttgtat tccttatatc gacatatttc tcgtatgtct 2943601 tcactgatca ttaattatag cataccgcct aaaaaaggtt aagtactcat gaggagaaaa 2943661 acattccaaa atatgtaatt acactcagac tccattggca ccaaggtctg ttgttcattc 2943721 gttcattcaa ttgtaaaatt ggaaacatat ttaaatttaa tgtaaagata atgttaatcc 2943781 tttgttgaag atttatgtta aaatataagg tagcttgatt ttgcttttag aaactctcgg 2943841 tttttaacta tataaataga atcttaaagg aaggaggagc cagacatgca aacagagact 2943901 attcacaata ttccttatgt taacagtaac ttaacatcat ttatcgatta cctagagaaa 2943961 cattatattg atcaaaagat tggtgctgtc atttccacag tcaaccctga aattgcattt 2944021 gcagctatta aagatcggga ctactttgat gtactatctt cttcaaactt cattttgcct 2944081 gatgggatcg gtgtagtcat gatgtcacgt ttgactaaca acaggcttca gtcccgaatc 2944141 gcaggttacg atgtttttaa agaacttctg ggcgttgcta acaaaaagaa aaaacgcata 2944201 tttctgtacg gtgcgaagaa agatgttata aaaggtgttg tatccaaaat ttcttctgaa 2944261 tacccaaaca ttaaaatcgc aggttattca gacggttatg ttcaagatcg caccctagtg 2944321 gcaaaacaaa ttgcaagagc aaatcctgac atggtattcg tagctttagg gtatcctcat 2944381 caagagaaat tcattcataa ctacagacac ttgttcccta aagccgtatc tataggtcta 2944441 ggaggaagct ttgatgtatt tagcggtaat gtcaaacggg ccccttcctg gatgatacgt 2944501 ttaaatttag aatggttcta ccggttaatc ttgaatccat ggcgatggaa aagaatgctt 2944561 agcatcccaa aatatgcttt aacggtttta aaagaagaaa aaaacaaaaa aactttctat 2944621 ccaaagcctg aaaaagatca tacaaaacag atttaaaaac aaaactttca aataaatgga 2944681 tgataaaaat gaaaataaga tcactactgg cgaattgcta tttgtatttt ttatcagcaa 2944741 tcgccttttt tctgcaatgg gtgaaacctg aaagcaaagt gaccctcctg atctcattcg 2944801 aagcaaacgc aaaagcgatt cttgaggaat atgaacaagg acaatactct tataaactta 2944861 acatcctgta tacccagcag gcctctgcta ttgccgagag cttcccgaat gtagatgcat 2944921 atttattaca agaaaaaaac cctatccatc tcattaaagc tgtataccta atgtttaaca 2944981 gtaaagtgat cataacagat aattactttc tattaacaag tgtgttaaat aagcggaagc 2945041 aaacgaaatg tatccaagta tggcacgcaa atggctcact caaaaaattt ggtttggaag 2945101 acattacaaa catgcaacgg acgaaaactg atattaaaag gttccaaaaa gtatacagtt 2945161 cgtatgatta tttaactgtt ggctcagaag agatggcaaa tatcttcaag aaatcatttg 2945221 gaataaagga taaccaatta ttaaaaatag gtgtaccttt aacagaccct tattaccgag 2945281 aaaacaagaa aaaaatttca gatactctaa acatacaaag aaaaaaaata atcctctatg 2945341 caccgacgtt tagagattat aatatgcaat caattcaatt gccttttaca gaagaacaat 2945401 taattcatca gttaaaagaa gaatatgttt tatttgttaa gctgcatccc gccattcaga 2945461 acaatattga tattaaatat tccagtgatt atattaaaga tgtttctaac tatgccttgt 2945521 ttgatctact catggctgca gacatattaa tcactgacta ttcttctgtt ccctttgaat 2945581 tttcgatttt aaataaaccc attctttttt atacttacga tttaaaactt tatcaacaga 2945641 agcggggatt ggttgataat tatctttcca taatacctgg aagagcctgc tatgacagtg 2945701 aatcattaat aaatgaaatt caaaccccat ttaattattc caaaataaaa gttttttccg 2945761 atagatggaa taagtattct gatgggaatt caagccaaaa tttattgaat ttcatcgaaa 2945821 atttaataag ctaaatgatg acacttgttc aaaacagaac aagtgttctt ttttctattg 2945881 aataccgaac gtatgtttgc tttaatgtaa ttagttgctt atggcagcaa ataataatag 2945941 aggtggtaaa tttatgagaa aaaaagaact gtttgatttc accaacatca cgccaaaatt 2946001 atttactgaa ctacgtgtag cagacaaaac cgtacttcaa tcattcaatt tcgatgagaa 2946061 aaaccaccaa atttatacaa cccaagtcgc aagtggatta ggaaaagaca acacccaaag 2946121 ctatcgcata actcgtctat ctcttgaagg tttacaatta gacagcatgc tgttgaaaca 2946181 tggaggtcat ggtacaaata ttggaattga aaaccgtaat ggcaccattt atatttggtc 2946241 tctatacgat aaaccaaacg aaacagataa aagtgaatta gtttgtttcc catataaagc 2946301 aggcgcgact ttagatgaaa attctaaaga acttcagcga ttctcgaata tgcctttcga 2946361 tcatagggtt acacctgctc ttgatatgaa gaatagacag ttggcaatta gacaatacga 2946421 tacaaaaaat aataataata aacagtgggt gacaatcttt aacctggacg atgcaatagc 2946481 aaataaaaac aatcctcttt atactattaa cattcctgac gaacttcatt atttacaagg 2946541 tttcttttta gatgacggtt atttatattg gtatacagga gatacaaaca gcaaaagcta 2946601 tccgaatctc ataactgtat ttgattccga taataaaata gtgctgcaaa aagaaattac 2946661 tgttggcaaa gacttgtcca ccagatatga gaataacttc cgtgaaccgg aagggatctg 2946721 tatgtacacc aatcctgaaa ctggggcaaa atcattaatg gtgggaatta caagtggaaa 2946781 agaaggaaat cgtataagca gaatttatgc ataccattct tatgaaaact tcatgaatca 2946841 tgtacctatg cttcgatccc ctttattaaa aaccgtgggg caccaagata cacctccaga 2946901 aagatttcaa ccatttattc aaaccttcat tttagagtat aatgctcaaa acaaaaaatg 2946961 gatggttccg acttcaggtt atttaccatc ttacacatca aatttagtcc gaaatattac 2947021 tatcaatgca gatggaaact tgcaagtcac attaaatgaa cgctatatta gtttactgca 2947081 tcaatcgata gaaggagatt tccgcttaaa acaaaaggat atccgaatgg gatcctggta 2947141 ttttgccggc ggagaaaaat caaatgtgct tgaaataggt tttatgaaag ggagtacaaa 2947201 aatcagaccc gatgatgcag ccatctcaaa tgcttcaaga atgagtattt ttatgattgt 2947261 tgcggacaag attgaggtgt gataatcaaa taggctgtag ctatttaata gctacagcct 2947321 atttgcaact ttctaagttt tttatcgata ttccggaaca tcggcctact ttatagacca 2947381 gcttctttcg gggcaatatg cataaagaaa agactccaga gattggagtc tttttctttt 2947441 attgcacccg tatacttcct gcgtatttat ccttccaata tgtgctcgtg ttcatattgg 2947501 taatggtcac gccgtttgat aatgtgacat gaacaacttg tccgtttccg atatagatgg 2947561 agggatttaa gcttgttgat tgaaagaaca caatgtctcc cggcttcagg tccgccttct 2947621 caatcttagt tccggcattg tactggcttg ttgcgtatcg aggcagggaa ataccggctg 2947681 ctttctggta tacatattgg acaaatccag ctgtatcaaa tcccgtctca ggtgttactc 2947741 cgccctgttt gtaaggcact tctccgacat aaagcgtcgc ttcggaaaca atcggatttt 2947801 ctttcgggat tgtcaggttg tcaaatcggc gaatacccgt catcttcgat ttccagtaat 2947861 cctctgacaa ataggaaatg gttacttttt ctgaccggct tgcctgaatg aacctgcctg 2947921 cgcccgcata aatgcctgca tgtgaaattc ccgttttata cgtattgctg aaatagacga 2947981 catcaccagg ctttatgttc tgaggggcta ccttctcgcc cactgcccac tgctgttcgg 2948041 ctgatcgcgg tagataaatg ccgagtgcct gttgaaacac atattgcaca agccccgagc 2948101 aatcaaagcc ctctgacggc gtgcttccgc caaacacata tgggacaccg atatattttt 2948161 cggcctcctg aacgacagga acatcagccg ttgccggatc ggcagcgatt cgtctcgccc 2948221 cgatataagt tccgctccaa tagctgcttt ttttgtaatt ggtgatgata accccttttg 2948281 actgtgtact gtgaaccatt tggccgtctc cgatataaag ggcgtcatgt gtcggaacag 2948341 tgccggtgct tccctctttc ttgaaaaaca aaatatcacc cggcttcagg ttttccggtt 2948401 ttacagctgt tccgatttta tactggtcgt ttacagatct cggcagatga atatcagcct 2948461 tactgaacac atattgtatc aatcctgatg gatcgaaacc ctctttcggc gtttccccgc 2948521 catatttata ctgatatcca agcaggtttt ttgcttcgct gacaatcaat tctgatgatg 2948581 tatcagcttc cgcaatctcc gcttttgtca taattggaac caaaaaacaa atgataaccg 2948641 ccacaagcaa aaacttcttc cagtttgcca gtgtgttcac ttttattatc tcctcctctt 2948701 tttgcagttt taacatcggt atttttttga atatgttaag agacttttta atatttttac 2948761 agaatgaata tgctgggcaa ataaaaagag agtgtctcat cagacactct cttttttgaa 2948821 ttatttattg gcgtttaccg gttcttcctg ctgctggatt ttattcattt ccatatcaat 2948881 cttctgtttt tcctgatctg tcagctgatc attgaattta aaagctgaca taaacatgaa 2948941 cacgatggct acggcaacaa acggccagat ggctttgaca aatttcatct ttatcactcc 2949001 gattatttag attttagttt gtcactatga tcaatatcaa acgtcagttt tccgtcttct 2949061 actttccaag cgaaattaga gtctttcgtc agttcgcgaa taatggtttt ctgtttaagg 2949121 ctgtcttttt tcacaggcgc aggtgtcgct tcatggatat cgatcggtgt cacttcaaag 2949181 cgtcctgttc catttttctt caggtgatac tgaaccagtg cactgtctct tgttctcgtc 2949241 cagccttggt caaagacaaa gttgccgagg ctgtagaaaa tgacggttcc gttatatact 2949301 tcaatcggtt ctaagacgtg cgggtgatgg ccgacgatga tgtcagctcc cgcatcagac 2949361 atggctcttg caagctggcg ctggcggtca tttggatcat tgtcatactc ttgtccccag 2949421 tgtgactgca caacaacaat gtccgcatgt tttttcgctt ctgaaatcat agggatgaag 2949481 atttcaggat ctgcgggcag cacgcccggc gtattctttt tagccgcgaa acctttcccg 2949541 gacacatcgg taaagccaag cgtcgcaatc gttaccccgt tgactttctg gtacgaaatt 2949601 ttctttttcg catcacttaa gctgtatccc gctccaacga tatcaagatt ttgcttcgca 2949661 aattctccaa gcgtatcttt catgccctga acgccgtaat ccattgcgtg gttgttggcg 2949721 ctgttgagaa ccgtgaaatt catatccttc aagactttca ctgattcctt attcgtctgc 2949781 agatgaatct ctttatctgc ttgtttataa ttcttttgat aggttaccgg gttttcaaag 2949841 tttcctgcta cataatccga ggctctaaag atcggttcaa catattgaaa aatactgtct 2949901 gccccttttt gctccgttac tttttcaaca tagcgtccca tcataatatc gcctacaaat 2949961 gaggctgaga gtacgtcgtc agaatacgtt ttgaccttcg gcgtttccgc ttttcccgcc 2950021 cacatgaaag cgaacataag gacaaaaacg atcggaatgg caataaatac gtgcttattg 2950081 gttttctttt tttgctgttt tgtcagcttt agcagctttt catgaaagct cagttctttt 2950141 ttcatcgttt gacacacctt acattaaatt aagtagtaaa caaacatgat agcaaaggtc 2950201 gctccgctca atagcagcgt gcttccgaac gtaatggtta aaccttgttt ctgaatggta 2950261 ttggcaatta aacctggcac gatgatgccg attcctcgaa attctgcgat ttcaaatggt 2950321 acaatcgggt atagaaaatc aaacgcgatt tttaggacga tccctgttat cagcatggca 2950381 gcgaattttc tgcgtccgta caaaatcata aatttggata aaccgtattt cacaatgaca 2950441 tacgtgagca agctcactag caaaacaagt aaaataaaga ccggctgatt aaacacaagt 2950501 cctaaatatc ccggtacaac aagtcctgcc ggcacgatcc ctgttttttc cgcaaaaatt 2950561 aaactgagta gtacacctaa aattagtgcg atgtataaat ctgatccgaa catgtctgca 2950621 tttcccccta gcttacgagc tgctttacct tgtattcgtg gattttttca attaaaggct 2950681 ctgcggcacc atgaatattg ccgacgccat atatgacacg gttgtgcatt cttttcttta 2950741 acaattccat aatttcatct gttgacttat actctagatc atgcagtttg tctgcaggaa 2950801 ttttgccttc ttcgtaggct tttacgatcg gttctgttgt ttcaccgatt aagatcagtt 2950861 cacttgcttc aatataaggc aatacgtcat ttgcgaattg ctgtgtccga tcgacacggt 2950921 ctgcgcggca gttcatgatg atgatcggat catcggtcgg gtaaccgatt tcttttacac 2950981 gtttccatat attcaaagta gaagaagcgt cgtttgcggc aaacccatta acaaagtgcc 2951041 caggctcgct cggactgatc agcggaagaa ttctcattgc tcccggatct ggcggcgcat 2951101 tcagcattcc cttaaatgct gtttcttcgt caatgccgag tgcttgagcc acacccagcg 2951161 ccagagaagc gttatcaggg aataccatgt attcaaattt acgtaaatac tcatctgtaa 2951221 tttttgagtt atcagcaatg atgacttttg tgtttcgttc ttttgctttt tgtttaaaga 2951281 actcggtata ttcactatct gtaatgacaa gatggccatt ataaggaatt gtagcagtaa 2951341 acgcttctgc aatttcatca agcgtcggcc ccatgacatc catatggtct tccaaaacat 2951401 tcacaatgac gccgatattg gcctgcagaa gttcttcctg aaagatgatt tgataatctg 2951461 ggttaacagc catgcattca ctgacaatcg cgttagcccc tctttctact gtttctctca 2951521 tgacttcttt ttgctctccg atattcggcc cctgaggttt ccgtttaatc ggcttttcct 2951581 ccggtgtgtc ccagtaaatc attcttgcat ctgttcctgt tgtttttcca acagtcttgt 2951641 aaccggcttc tattaatatt ccggttgtca gccttgtcac agtcgatttt ccgcggatgc 2951701 cgttaatatt cacccgaaca gggagggcat caatgttttt ctgatgtcgt cgtttttcta 2951761 atattccgat gaccagtatg acagcacagg ctataatgag taaccacatt gcttttcgac 2951821 atctccttct atattgttgt aaattcattc atcagtatat agaatcacta tgaattctca 2951881 atcggcatta tgtaacataa tcttccctaa tcgactaagc caaacttctc ttttgaaaga 2951941 gattttatac ctacaaactg ttttctattt ttggaaaaca gcaggactta taccttatca 2952001 ctttttaaaa aaatcaaaga gaatgcgctt tcatttttct cctgatatcc ttctggacgt 2952061 atagtcacac cctgctgttt gtatttaata tgcatttcaa atcaatcttt ttttcagcct 2952121 ttgttatcaa gcatttcctg ctatcatgcg tgtttccggt tcttatgaac acaaaataat 2952181 tttatcctgt ttcttaagga caaggtcata atgtcatcct ttctgcatgg aataagcaat 2952241 atgaggccca ttccaaaatg actaaggagg ttcgagatga aaacgctaaa catacgagtc 2952301 cgaattctct aacataatta aacattttct gggatgatag tcttttctgt ttctccccat 2952361 ttacaggtct aaacgcatga ctttgaaaca attttaataa aacttaatat ttgttcaaga 2952421 aatcttcatc catatttgtg aagactttgt caaaaaaaga gtgaaaacct taaatttttc 2952481 aattatatat acaatttaca attagatttc ttttgatatt tttattgcta acttcggatt 2952541 gttcatgata atctatctat gtaaacggtt acataaacaa ggaggagctg ttttggctac 2952601 aattaaagat gtcgccggag cggcgggcgt ttcagttgcg acggtttccc gcaacctgaa 2952661 tgataacggc tatgtacacg aagaaacgcg aacgcgtgtc atagcggcga tggcgaagct 2952721 gaactattac ccgaatgaag tcgccagatc tctatataaa agagaatccc gactgatcgg 2952781 acttttgctc ccggatatca caaacccttt cttcccccag cttgcccgcg gtgcggagga 2952841 tgaattgaac cgggaaggct atcgccttat tttcggcaac agtgacgagg aattgaaaaa 2952901 agaacttgaa taccttcaaa cctttaagca aaatcatgtc gcaggcatta ttgccgcaac 2952961 gaattacccg gatctcgagg aatacagcgg catgaattat ccagttgttt ttctggacag 2953021 aacgcttgaa ggggctcctt ctgtgtccag tgacggctat acaggagtaa agttagccgc 2953081 ccaggctatc attcacggaa aaagccagcg cattacgctc ttgagaggac ccgctcacct 2953141 gccgaccgct caagaccgat ttaacggcgc tttggaaatc ttaaagcagg ctgaagttga 2953201 ttttcaggtc attgagacag cttcattttc aattaaagat gcacaatcga tggcgaagga 2953261 gctgtttgcc tcttatccag cgacagatgg tgtgatcgcg agtaatgata ttcaagccgc 2953321 tgccgtttta catgaagcat tgcggcgcgg aaaaaacgtg ccggaggaca ttcaaattat 2953381 cggctatgat gacattccgc aaagcggact tctgttcccg ccactttcta caattaaaca 2953441 gcccgcatat gatatgggga aagaagctgc caaactgctt ttgggtatca ttaaaaaaca 2953501 gccgctggca gaaacggcaa ttcaaatgcc tgtcacctat ataggaagaa agacgacaag 2953561 aaaggaagat taagatgcgt aatatttgtg tgattggtag ctgttctatg gatttagtgg 2953621 tcacctcgga caaacgccca aaagccggtg aaacggttct tggcacgtca tttcagactg 2953681 tgccgggcgg caaaggagca aatcaggccg ttgccgcagc cagacttggg gcgcaagtgt 2953741 ttatggtcgg caaagttgga gacgatcatt atggaacagc tattttgaat aatctcaaag 2953801 ctaacggcgt tcgcactgat tatatggaac cggttacaca tacggaaagc ggaaccgctc 2953861 atattgtgct tgctgaaggc gacaacagca ttgtcgttgt caaaggcgcg aacgatgaca 2953921 tcaccccagc gtatgcgtta aacgcgctcg aacagattga aaaggtcgat atggtgctga 2953981 ttcagcagga aatcccagaa gaaacggttg atgaggtgtg caaatactgc cattctcacg 2954041 atatcccgat catactaaac ccagcaccgg cccgcccgct caagcaggaa acaattgatc 2954101 acgctaccta tctgacgccg aatgaacacg aggcttcgat tttattccct gagcttacca 2954161 tttccgaagc tctggcgctt tatccggcaa agctctttat tacggaagga aaacaaggcg 2954221 tccgctattc ggctggcagc aaagaggtgc tcatcccgtc cttccctgta gaacccgttg 2954281 atacaaccgg agccggtgat acgtttaacg cagcatttgc cgtggccctg gctgagggaa 2954341 aagacattga agccgcattg cggtttgcca atcgtgccgc ttccctttct gtctgctcct 2954401 tcggtgccca aggcggaatg ccgacaagaa atgaagtaga ggagctgctg tcatgaaaaa 2954461 acacggtata ctgaacagcc atcttgccaa gattttagcc gaccttggcc acactgataa 2954521 aattgtcatc gcggatgccg gactgccggt tcctgacggc gttttgaaaa ttgatctttc 2954581 actgaagccg ggccttccgg ctttccaaga tacagcggca gtactggctg aggaaatggc 2954641 ggtcgaaaaa gtcattgctg cagctgaaat aaaagcatcc aatcaggaga atgcgaaatt 2954701 tctagaaaat cttttctctg aacaagagat tgaatacctt tctcacgagg agtttaagct 2954761 gctgacaaaa gatgcaaagg cagtcataag aacaggagaa ttcacaccat atgccaactg 2954821 catcctgcag gcaggtgtac ttttctagaa aggaagatga aacatgcaga ttgaaatgaa 2954881 agacattcat aaaacattcg gaaaaaatca ggtgctgtca ggcgtttcct ttcagctcat 2954941 gcctggcgag gttcacgcat taatgggaga aaacggcgcc ggcaagtcca cgcttatgaa 2955001 cattttgaca ggcctgcaca aagcagataa aggtcaaatc agcataaacg gaaacgaaac 2955061 gtatttttcc aatccgaaag aagcggaaca gcatggaata gcctttatcc atcaggaatt 2955121 gaatatctgg ccggaaatga ccgttcttga gaatctattt atcggtaaag agatatcctc 2955181 caagctgggc gttttacaaa caagaaaaat gaaagcgcta gcaaaagagc aatttgacaa 2955241 actttccgtc tctctttctc ttgatcaaga agccggcgaa tgttccgtcg gacagcagca 2955301 aatgatcgaa attgcaaaag cgcttatgac aaatgccgag gtaatcatta tggatgaacc 2955361 gaccgcagcg ttgactgaac gtgaaatcag caagctcttt gaggtcatta cagcgttaaa 2955421 aaagaacggc gtctccattg tctatatttc gcatcgcatg gaagaaattt ttgcgatttg 2955481 cgacagaatt accatcatgc gtgacggaaa aacggtagat acaacaaaca tctcagaaac 2955541 tgattttgat gaagtcgtca aaaaaatggt cggacgggag ctgactgaac gatatccaaa 2955601 acgcactcct tctctcggtg acaaagtatt cgaggtgaaa aatgcttccg taaaagggag 2955661 ttttgaggac gtcagctttt atgtgcgttc cggtgagatc gtcggtgttt caggattaat 2955721 gggagccggc cggacagaaa tgatgagagc gctgttcggc gttgacaggc tggacacggg 2955781 tgagatatgg atcgctggga aaaaaacggc tattaagaac ccgcaggaag ccgtgaaaaa 2955841 aggtctcggc tttattacag agaatcgcaa ggatgaaggg ctcctgctcg acacctcgat 2955901 ccgcgaaaat attgccctgc ccaatctgtc cagcttctca ccaaagggtc tcattgatca 2955961 taagcgggag gctgaatttg tcgatctgtt aatcaagcgc ctcactatca aaacagcatc 2956021 accggaaacg cacgcacgcc atttatcagg aggaaaccag caaaaagtgg tgatagccaa 2956081 gtggatcggc atcggaccga aagtgcttat cttggatgag ccaaccagag gtgtggatgt 2956141 tggcgccaaa cgagagattt atacgctgat gaatgagctg accgaacgcg gtgtcgctat 2956201 catcatggtg tcatcagagc ttcctgaaat tctgggaatg agcgatcgga ttatcgttgt 2956261 ccatgaaggc agaatcagcg gcgaaatcca tgcgcgagaa gcaacacaag aacgaattat 2956321 gacacttgcc acgggagggc ggtaatatga aaacggaaca actgcaaaca gaacaaaaac 2956381 ggattcactt cgacggagtc atgcaaaaac tcggcccgtt tcttggttta tttattctcg 2956441 ttatcattgt atctatttta aatcccagct ttcttgaacc gctgaatatt ttaaacctgc 2956501 ttcgccaggt cgccattaac ggattaatcg cgttcgggat gacctttgtt attttgacag 2956561 gcggcattga tctttctgtt ggcgctattc ttgccctgtc cagtgcttta gttgcgggga 2956621 tgattgtgtc cggtgtcgat ccggttctcg cgatcatcct tggctgtatc attggtgccg 2956681 tactaggcat gatcaacgga ttattgatta ctaaaggaaa aatggcgccc tttatcgcca 2956741 cgcttgcgac catgactgtg tttcgcggac tgacgctagt gtatacagat ggaaatccga 2956801 ttaccggact tggcacaaac tacggttttc agatgttcgg acgcggttac tttttaggca 2956861 ttcctgtacc ggcaattacg atggttcttg cctttgtcat cctttgggtg cttcttcata 2956921 aaacaccatt cggacgccga acgtacgcta tcggcggcaa cgaaaaagcc gcgctcattt 2956981 caggcatcaa agtgacgcgc gtgaaagtga tgatctattc tttagccggg cttttatccg 2957041 ctcttgcagg tgccatattg acttcccgcc tgcattcggc ccagccgact gcgggagaat 2957101 cgtacgaact tgatgctatc gcggcagtcg tcttaggagg gacaagtctt tccggcggcc 2957161 gaggacgcat tgtcggcacg ttaatcgggg tgctgatcat cggcacactt aataacggac 2957221 ttaatctgct tggcgtctca tcattttatc agctggttgt caaagggatt gttatcttaa 2957281 ttgcggtatt gttagaccgc aagaagtcag cttaggaggg ttttacatga aaaaggctgt 2957341 atccgtcatt ttaacgttat cattattttt gttaaccgcc tgttcgcttg agcctcccca 2957401 atgggcaaag ccatcaaact cggggaacaa aaaggaattc accattggct tgtccgtctc 2957461 aacgcttaat aatccttttt ttgtctcatt aaaaaagggt atcgaaaaag aagctaaaaa 2957521 acggggaatg aaagtcatca ttgttgatgc acaaaatgat tcatcgaaac agacgagtga 2957581 cgtggaagat ttaattcagc aaggtgttga tgcattatta atcaacccga ctgattcttc 2957641 ggcgatctca acggcagtag aatctgcaaa cgcagtcggt gtgcccgtcg taacaatcga 2957701 tcgatctgcg gaacaaggaa aagttgaaac cctcgttgct tccgataatg taaaaggcgg 2957761 tgaaatggcc gcggcgttta ttgccgacaa acttggaaaa ggagcaaagg tggcagagct 2957821 tgaaggcgtc cccggcgcat ctgccacacg ggaacgcggc tcaggattcc ataacatcgc 2957881 agaccaaaag ctccaagttg tcacaaaaca atcagctgac tttgaccgca cgaaaggcct 2957941 gactgtcatg gaaaacctgc tgcagggaca tcctgatatc caagctgttt ttgctcacaa 2958001 cgatgaaatg gcgctcggtg ctctcgaggc aattaacagc tcggggaaag acatattggt 2958061 gatcggtttt gacggcaata aagatgcgct cgcttccatt aaagacagaa agctgtcagc 2958121 caccgtcgct cagcagcctg aattaatcgg taaattggct acagaagcag cagatgatat 2958181 tttgcacggg aaaaaagtgc aaaaaacaat atccgcgcct ctcaaactag aaacacaaaa 2958241 ataattgtct gatgtttagg aacctgcgat aacgtgaata gagatataga atgaattatt 2958301 tctcttacgt gaggagagga acggcatgaa caaaccaaca aaactatttt caacattagc 2958361 acttgcggct ggaatgactg cggcggctgc tggcggcgct ggcacgatcc atgctcaaca 2958421 gccagaaaca acggtaagca ttgatgattt atacagttat ccgattgatt cttatttggt 2958481 atcagcagag gctctaaatg tcagaacgaa gccttccgca tcaagccaga aagccgatac 2958541 gctgcactta ggagatagcc taaagctgat ttccttctca aatgctgact gggcaaaggt 2958601 taagtataaa aatggaaaaa caggatttgt atccactcat tacattgtta aagcagcgac 2958661 aacggtaaaa accaaaacaa aaacaaaagt gtatacatcc gctgacggaa agagcattaa 2958721 gactcttcca gcagacacaa gcgtttcttt tttaggctgg agtaaaacga ataaaggcgg 2958781 ttttgatttt gattgggtat tcgttgatta cggcggtacg acaggttata tgaaaacaaa 2958841 ggatttacac atgacaaaat aactgagagg gattccgcat aaatgcggaa tcccttttat 2958901 tatgaattga tttgtcacat tcccaagata tttctcagga aatattgtcg tatgctgtgt 2958961 cgaaacctta catgatcatc gacatttttg ttcacgctaa aaagcggagg tgtaaatatg 2959021 gatcaatttg aagcagcata tgaatcgtat aaagcccggc aaacaactgc cgatcaagaa 2959081 aatgttccat ctggaaaaga agaaattatt gcggttagaa gaaatgagga agacaatatt 2959141 atcgcagtga aaaccaatac aggaagagag ctcgactacc ctactgcgct gtcagaagca 2959201 aaatcaggaa aactcgctca tgttgatgtc ttccataaat acgggcgtga cattttgcga 2959261 agtgaaccgg acggcatcaa ggaaaataac ctgtctgagc tgccggattt ttaaacaaat 2959321 acagccctgc cgtatgttgg acagggctgt attttaaaca aaaggctgct ggatgtattc 2959381 ggctaaccgt tttgcactgt gagaaatatc ctctgcagct gcataattca cgccatagaa 2959441 cacatatgga ggcagatact tcatgccgat cagattactc gtggcctgaa atggtttcaa 2959501 tagctcactg atcgagtaat gatttgctcc gcccgcttga tatttttccg cttcgctccc 2959561 tgttgataca gccagcatca gctccttgcc atgcaaggca tttccttctg aaccaaaagc 2959621 ccagccataa gtcagcacaa gatcctgcca ttttttcaag agcggcggag agctgtacca 2959681 atatagcggg aattgaaaga caatccgatc gtattcctcg cacagctgct gttccttcgc 2959741 aacatctatc gcttcatccg ggtattcctt ataaagatcc cgtactgtga tattgtcatg 2959801 tttactcaat tcctcagccc acgccttatt aacaactgag gtctccatat gaggatgcac 2959861 tgccaaaacc aatattttca tcagaccaca cctttactgt tttgatgtta ttttatctaa 2959921 aatcaggaaa agagccaaat aaaaagaaag ccctgctaaa aggggctttc tttttttctt 2959981 ttattcaggg cttccttcag ttgtttcgat atctttcgca aaatcagggt tatccagatt 2960041 cgcattaaag aaatccgctg tgttcggaag tctgagattc atgttcattt tttgagaaat 2960101 cgtaaccgtg caatcctcaa gcacatagtc aaaaacgtgt ccgcctgaat tgcgtccttc 2960161 gtcaatgaag tgcaggtgat agccagaaac ggcgattccg tttgcataag ctggtgtcaa 2960221 gaaacctaca atcgttcctc tcacgttgtc gaagttgaaa atcggctgtg ttttgaccgc 2960281 ttcaaccatt ggcacgtaag gtttttcttg aagttctact gttcttgtct gcaccttttt 2960341 aaacaatccg tcaatgcgaa ttgcataaaa taagtttctg cttggcagca tgctgttgat 2960401 ctctttttca aagtcttcgc gtgtcatttt cgcatcaatt ttgtgcgtca tgtccggtgt 2960461 aaagaacgta aatgaacaga acggtgaacg gtctccattt tggaccggtg tcgcggttcc 2960521 gtctgagcga agacggtaaa attcgccgtc aaacccaatc agctctccgt caagcttgtt 2960581 aaaggttccg ataccgaagt ctccatattt cggaatctct gacagttcaa aatctccgtc 2960641 atatactccg tctaatagag aagtcattgt tgatacttga taaatctggc tcacaggctg 2960701 atctttttga ccacggctga gcacttgaat gttgctttct cgtttcatat ttcccttcac 2960761 tccttttatt tagtgctgtt cataaaacag tgtcgtgatg cgcagagtgc tagagagctt 2960821 tcgttttcat gagttccccg aattctttcg gaagcttgtc acttgctaaa ttaatgttat 2960881 cactgtagtc aaccgggaca tcgatgatga caggaccttc agcgttcatg ccttgacgca 2960941 gaacatctgc cagctggtct ggtgattcta cgcgcaagcc agttgctccg aagctttccg 2961001 catatttcac gatatcgata tttccgaaat cgaccgcaga tgtacggtta tattttttca 2961061 attgctggaa tgcaaccatg tcatatgtgc tgtcgttcca tacaatgtgt acaattggtg 2961121 cttttagtcg aactgctgtc tctaattcca ttgctgagaa taagaaaccg ccgtcaccag 2961181 agacagaaac cactttttct cccggtttca ccaatgaagc gccgattgcc caaggaagcg 2961241 caacgccgag tgtttgcata ccgttactga tcattaatgt taacggctcg tagctgcgga 2961301 aataacgtga catccaaatg gcgtgcgaac cgatatcgca agttactgta acatgatcat 2961361 cgactgcatt acgcaactct ttaacgattt caagagggtg cgctctgtct gatttccaat 2961421 ctgcaggcac ctgctcacct tcatgcatat attgttttaa atcagaaagg attttctgct 2961481 cacgctctgc aaattccact ttcacagcat cgtgttcgat atgattgatc gtggacggaa 2961541 tgtcaccgat caattcaaga tcaggctggt aagcatgatc aatgtcagcg ataatctcgt 2961601 ctaaatggat aattgtccgg tctccattga tattccagaa tttcggatca tattcaatcg 2961661 ggtcatagcc gatcgtcaga acaacatctg cctgctctag cagtaaatcg ccaggctggt 2961721 tgcggaacaa accgatacgg ccaaaatatt gatcctctaa atctctagaa agggtaccgg 2961781 cagcttgata tgtttcaaca aatggaagct gaaccttttt caaaagcttg cgaaccgctt 2961841 taattgcttc cggtcttccg cctttcatgc cgaccaaaac gacaggaagt tttgctgttt 2961901 ggatttttgc tatggccgca ctgattgcat catctgctgc aggaccgagt tttggcgctg 2961961 caacagcacg cacgtttttc gtatttgtga cttcattcac aacatcttgc ggaaagctca 2962021 caaaagcggc cccagcctgc cctgctgacg ctatcctaaa tgcatttgta acagcttccg 2962081 gtatattttt tacatcttga acttctacac tgtattttgt aatcggctgg aatagcgccg 2962141 cattatccaa agattgatgt gtccgtttta aacgatctgc acggatcacg tttccagcaa 2962201 gcgcaacgac agggtctcct tcagtgttcg ctgtcagcag gcctgttgcc aagttagagg 2962261 cacccggtcc tgatgtgact aacacgactc ccggttttcc agttaaacgg ccgactgctt 2962321 gggccatgaa tgctgcgttt tgttcgtgcc gggcaacgat aatttcaggt cctttatctt 2962381 gtaaagcgtc aaataccgca tcaatttttg cacctggaat gccaaataca tgtgtgacac 2962441 cttgctccac taagcaatca acaacaagct ccgcccctct gtttttcaca agggattttt 2962501 gttcttttgt tgcttttgtc aacaccctca ctccttatta tgcattttaa acgtaaaatt 2962561 ttaaatatct tgtgataagt ttcactatac actctttgga aattgacctc caatatcgat 2962621 tcgccttatg attaatatgt aatacgaatt attaacctat ggaaaggaat gcatattgaa 2962681 tggagcttcg ccatcttcaa tactttatcg cagtagccga agagcttcat ttcggaaagg 2962741 ctgcccggcg gctgaacatg acgcagcctc ctctcagcca gcagatcaaa cagctggagg 2962801 aagaagtcgg agttacgctt ctgaaaagga caaaacgatt tgtcgagctt accgcagcag 2962861 gagaaatctt tttaaatcat tgccgcatgg cattgatgca aatcggacaa ggaattgaac 2962921 tggcacagcg gacggcccgc ggcgagcaag gccttctcgt aatcggtttt gtcggatcag 2962981 ctacatatga atttctgccg ccgattgtcc gggaatatcg taaaaaattc ccatctgtga 2963041 aaatagaact gcgtgaaata tcctcgtcta ggcagcagga ggagctacta aagggcaaca 2963101 ttgatattgg tatacttcat cctcccttac agcatacagc tttacatatc gaaaccgccc 2963161 aaagcagccc ttgtgtttta gctttgccta agcaacaccc attgacttct aaggaatcaa 2963221 ttacgattga ggatttaaga gatgaaccaa ttattactgt tgctaaagaa gcatggccta 2963281 ctctatacat ggattttatt cagttctgtg aacaagcggg cttcagaccc aacattgtcc 2963341 aggaagccac agaatatcaa atggtgattg gtttagtcag tgccggaatt ggtatgacat 2963401 ttgttccttc ctcggccaaa aaattattta atttggatgt tacttatcga aaaatggacc 2963461 aaatacagct taatgcagaa tgggttatcg cttaccgcaa agacaatcat aatccgctta 2963521 taaagcattt tattcatatt tcaaattgtc agcagacaag aactaaagag agtgatgcag 2963581 gtacatgaac aatacttgca atctcttttt tcttttggga ttcttatgga atttttatta 2963641 atttaatata atcgcttagt acaactttat atcagtatac gtatacatac agtacaaata 2963701 gttggcaagg acatcagtaa gcgcaggaca ttagtttgat tttaaaaatg aaagatagag 2963761 aggtgaagta aattattgag ttcaccggca tattcacatt gctcgctttt ttcgtaacaa 2963821 tgatttttat tttctggaga ccaaaaggac taaatgaagc tatccccgcc acatttggcg 2963881 ctttaatggt tttattgtgc ggaagtgtgt cattggcaga cttaggggaa atcggaacaa 2963941 aagtcacggg tgcatcggtt acaatccttg ccactatgat tatggccatt gcactagaaa 2964001 gctttggttt cttttattgg gtggctgcaa aactgctcca acaatccaag ggttcaggca 2964061 tcaagctttt ttggctaacc aatttgctct gctttctcat gaccattttc cttaataatg 2964121 atgggagcat tttgatcaca actccaatcc ttttgcttgt actaaaatat ttaggtttaa 2964181 aaaaacatca aaaagcccca tatttattaa gcggtgtttt aatagccaca gcctctagcg 2964241 caccgattgg cgtaagtaat attgttaatt taatttctct caaaatcatt ggaatggatc 2964301 tatatcttca caccgccatg atgtttgtcc ctagtatgat gggactcatt tttatgactt 2964361 gtctactgtt tatgttcttt tataaacgtc ttcccaaaag cctgccagat ataccgggcc 2964421 attttcagtc tctgcggcat agaaggtacc atcctcttca ttcgccatca gctcctttac 2964481 cagaacgaaa tcaaacaaaa atcatgttgt ttgtgcttgc atttgttttt ctcgtcagaa 2964541 tgagtctatt tgcagcatca tataccggta tttctgttcc tctagtcgct gtcatcggat 2964601 cttttatcct gttgagctgg agatggattt atttcaaaac ctccccaaga gacttgttat 2964661 ataaatcgcc ttggcacatt tttatattcg cttttactat gtatgtctta atttatggtc 2964721 tgcataatat tggattcaca gagttacttg tgagttattt tgaacctgtg gtttctggaa 2964781 gcctcgccca tgcaactttc gcatcaggta tctctacttc agttttttct aatctcttta 2964841 acaaccatcc agcgttaatg atcagtactt ttaccttaac tgaaatgacc ctgaatcctt 2964901 caacaacaaa aatcatctac ttggcaaata ttatcggcag tgatatcggt tcattattat 2964961 tacctatggg aaccttagca acgcttattt ggatgcatat attaaaacag catgatgaaa 2965021 gtatttcatg gggcgaatat ataaaaacga ccattatcat cattccgctg actgttcttt 2965081 ttacgttaac atgtttatat ttttggatca gttggttatt tctttagcac agtatgaaac 2965141 gaaaaactgc cttctgcttt tcaagagggc agttttgtat acactaggga agatgcattg 2965201 tctttagatg atttaacttc caaatgactg gctctccact tgcgttaata agctcaatga 2965261 tattattaga gacacccttt aatagtccga ctttttctgg cacctctccc atatcaaata 2965321 tgaccaattc accaatattt tttttgatct gctcctcaaa attacgcaca agaggaactt 2965381 tggaaggcac gaccggcaat tgtgagttgt caagagtata cggtgtttgt tcagttgaat 2965441 aaggggtaaa ccattttaaa tgatgcatag atataaaaag tattttaaat acgggtgaga 2965501 aaaatacaat ataatcgttt aaaacatttg taacatatcc atggatcgat cgacccccag 2965561 ttacataaac ttcaataaac tggcctttga ccttgtttaa tgtatttcta tatgaaaaag 2965621 cttgagtttc tgcctctatc attggatctt ccggattgat caaaaatggc ttctcagtac 2965681 tggtcactat tttcgccttg tttatttgat gaagatgcaa caagggaata taaagataat 2965741 tgcagccatc aaaaataaca aaaatatcct gtccgatatc tatgagggtg ccgacaaacc 2965801 ttgtatctcc tgaaatgaca acctcaacat ctgtgttaag gaattgattc aaacctttca 2965861 cgattctcct cctttaactg aaaaagggca tcactttatc tgatgctcct ccattatcta 2965921 ttaaaattta cgtttccagt gatagtctat cgttctgaca atcgtttcat agctataatc 2965981 ttccttttgt tttcctgaac tttttattga acttgaatag cctggtgatc ttgatgattg 2966041 ataatctgaa gatcttggtg atcgtttaga tgattttgat gattgataat ctgaagattt 2966101 taatgatcgt ttagatgatt ttgaagaact ttttgaacgt gacgaacggc cagatttgga 2966161 tgattgataa tccgaagatt ttagtgatcg tttagatgat tttgaagaac tttttgaacg 2966221 tgacgaacga ccagatttgg atgattgatc atctgaagat tttagtgatc gtttagatga 2966281 ttttgatgag ctatatgatt ttgaagaaat gaacgaattg ctgtccttat cattattgtc 2966341 ttcctggttt tgttcatttt tttgatcctc ttttttgtac gacccttttg gacctaagct 2966401 gatgcttttt atgtgaaaag gatagatgcg aagcacctct tgatttttca ctatagtata 2966461 atggccgtcg gcattatcta caaggatacc ctcaatggct tccggacctc cacgattaat 2966521 tgaaacccat ttatgagtca gactcttaaa aacctcgctt aaatcatcag cttccaaaac 2966581 tccaactggc gtctgctctt ctattttcaa atcaggctcg tgtttactta tacttttgat 2966641 gtgatggata ttaaaataca ctaccccatc ctcatttgtg tttaacgcag cgtaatcatc 2966701 tcccagccag accaatcttc cttttttaga ttccggaccc ccttggttaa attgaactga 2966761 ttggtttatt aaatgtccga ttaagctatg aaaatcatca gcatcgagca tttcctcagt 2966821 ctcaattgtt gtggtgctat tattggtatc ctcagtaata cttttcacat gctccaactg 2966881 ataataaatt attttttttt cagcttgtaa agctatataa tctgatttta cagctgttaa 2966941 ttttcctttt ttagattccg gacctccacg atatacagta acaattttat ctttcattga 2967001 gtgcaaaaag ttataatacg atatttcatt atttgaatga tatttcattc tcctcttgct 2967061 cattcaaatt cctcctagtc acttatacat agatgataaa catactgcat atatacgtgt 2967121 cacatttatt tgttgaacta attcaatagc ctaattgtcg ctttttccgc gaatacccat 2967181 tttcacgcat tcataaaata cttaaatgat ctttgaggta ttgtgaacgg tttttaatat 2967241 actcgcagat cacatccggc tcacggtcaa aacgctcaat atcattcttt ttatacgggt 2967301 ccatgaggac aaacggccta atccgttcat acatcgccat gattttcggt tccatatatt 2967361 ctattgtaaa aagagattgg agcgtttttt ctaacaggcg cttgtaggac ttgcgaaact 2967421 cggattcatc caatatccgg gcggttagtg tattaaatcc ttgaattctt acataatcgg 2967481 cagccatccg ctctccatgg atatccctgc cccaagtcgc atcataatcc caaggaatca 2967541 cctcaaataa tccggtttcc ccgcttctgt ataatgcgta gttgtggaca aacccgtcat 2967601 agttcgaggt gaatacaata ccagcaagcc agcgcaaata cttatcgaca tccacgtgtt 2967661 ttgtcacttc tgacttaaac tgagctttag ggaccgtatt aattttaaaa atcatatctt 2967721 gtaaataaaa atcatcttcc tcagtccctg ttttcttttc atatccaagc tccagcgatg 2967781 ttttcgtttc cctttctaaa tcgctcatca gagaaaagtt ggcatcatca tccaccgcat 2967841 aaaaaatcgc gccatcagcc agcttccttt tcgccaaata atattcatct acggattcaa 2967901 gttcaagata aaccccttca ttcttcccat tcatctttac aaacgcaaac tctgcctttg 2967961 gagacagtgt ccctagctcc gagaaaaaat ccagagacaa tttgtttctc atcaaggaag 2968021 ggtctttata ctccgcattt aagtgaatct ctcgcgcgcc gcggaatgtt ttcggctgat 2968081 aaaaggaaat atggtatgac ttctttttga agtctctgat atgtgatccc cgataagcga 2968141 tatcaatatc cagccttttt tgatttacct tcatcacagc tggcaccgga tcatcgtccc 2968201 atatatcctt ttttaattca cgcaagtctt ttggatgaac aaacagctga taaagcggta 2968261 aattggattg attcttcatc cataatcctc cttacaaatt ttaggctttt atttttataa 2968321 gatctcagcg gaacacttat acacttttta aaaccgcgcg tactatgagg gtagtaagga 2968381 tcttcatcct taacatattt ttaaaaggag gatttcaaat tgggccacta ttcccattct 2968441 gacatcgaag aagcggtgaa atccgcaaaa aaagaaggtt taaaggatta tttataccaa 2968501 gagcctcatg gaaaaaaacg cagtcataaa aagtcgcacc gcactcacaa aaaatctcgc 2968561 agccataaaa aatcatactg ctctcacaaa aaatctcgca gtcacaaaaa atcattctgt 2968621 tctcacaaaa aatctcgcag ccacaaaaaa tcatactgct ctcacaagaa atctcgcagc 2968681 cacaaaaaat cgtaccgttc tcacaaaaaa tctcgcagct ataaaaaatc ttaccgttct 2968741 tacaaaaaat ctcgtagcta taaaaaatct tgccgttctt acaaaaaatc tcgcagctac 2968801 aaaaagtctt actgttctca caagaaaaaa tctcgcagct ataagaagtc atgccgcaca 2968861 cacaaaaaat cttatcgttc ccataagaaa tactacaaaa aaccgcacca ccactgcgac 2968921 gactacaaaa gacacgatga ttatgacagc aaaaaagaat actggaaaga cggcaattgc 2968981 tgggtagtca aaaagaaata caaataatct aagttttcat tgtttcaata ggctgccggc 2969041 ggaggtacgg aagcctattt ttttatttgc cctgtattag atatatgtca tgacataaca 2969101 tatgcaaccc gcatcatttg gtttccttta aaccatttcg ttataatcaa ggtatcctaa 2969161 cgataaaggc ggttgttgct atgtacatat ttcaagctga tcagcttagt gccaaagaca 2969221 catacaagct attgtcaggt accgttattc cccgccccat tgcatttgtg acaacacttt 2969281 cttcaggagg agcggtaaat gccgcgcctt tcagttttta taacgtcgtc agctcagatc 2969341 ctccgcttct cagtatttct gttaacagga cggaaggacg ccaaaaagat acagcacgaa 2969401 acgcagtgga gaacggagaa tttgtcgttc atgtcagtga tgaagccatc attgaagata 2969461 tcaatgaaac agctgcaagc ttaaggccgg atgaaagcga gcttacacgc acctcgcttc 2969521 atcctgttga aagcaaagct gtttcagttc ccggcattaa ggaagcccgc gttcgctttg 2969581 agtgcaaatt agagcggcat attacctttg acaatgatca aggcatcact acagcagatc 2969641 tgctcatcgg aagagttgtc tgcttccacc tagatgaaaa ggtgtatgat gcagaaaagg 2969701 gatatatttt aacggatgaa ttaaagcctg cctcacgatt ggcgggaaat cactatgcca 2969761 agctggggga agaattcaca ctgattcgtc ccagctgaag agaaggacta tttaaataga 2969821 agaaactagt caaaaagacc ttatgattac aaaatatcgc ctgtaaataa ctgaaaaaat 2969881 atcaaaaaaa agaacaccca gagcaagctc ggggtgttct tttatgaaac gtttttcctt 2969941 tttcttcgta taaaggtaga ttaggaggaa ttggaatgac aaacttttgg attttaatgc 2970001 tgatcgctat taccatcagt ctcgcctctc aattttttat aaagaaaaaa tacggtattg 2970061 ataaatccgg ctggcgatat aagcatgtca gcaatacaca caaatggatc gaaatcactt 2970121 tacttatttt gtttgtgttt tcactctcct tttttccagt tgaatatttg cttcttttat 2970181 tttttattgt gattgactca atacgtattt ttatggagtg gcattataga cctgaagata 2970241 aacagtatat gtaccacatt gtagaggtct cccttatgtt tatgcttttg atttatgttt 2970301 gtaccctata gttatttaaa tccccacagc cgctccgtct ccccgaggat cggctccgcc 2970361 ttggagaaag ccttcttcat caactttgat tgcagccgct tgtcccatca gcggatcata 2970421 gtcaccgaca acctccacga gatgcccgct gtctttcagt ttttggattg ttttgtctgt 2970481 gaatctgccc tcgactctga gaccttcgta ttcctctccc cacgttctgc cccataccca 2970541 gcgcggttcg ctgattgcct gctgtggatg cattccgtag tccagcattc gggtaatgat 2970601 ggccgtctgg gtctgcggct ggccttcgcc gccttgtgtg ccgtacagaa tttttggctt 2970661 tccgccttta cagaccatag ccggcatcaa cgtatggaag gtgcgctttc tcggttcaag 2970721 cgtgttgaca tgattttcat ccagtgagaa aaacgatccg cggttttgca gtaatatgcc 2970781 tgtatcaccg gcagtgactg ccgagccaaa ttcaaagtac aggctttgaa tgaatgacac 2970841 tgcgttgcca tccgcatcga ttacggccgc atatgccgta tcacttccca ccggcctgct 2970901 ttctgccggt attgcgagat agccgatttc ttctgccaat tgttttgcat aacgtttgtc 2970961 caaaagcctt tcaagcggaa tgtctgcaaa cgccggatca gtcaggacgg catcccgatc 2971021 tagaaaactc tttttcaatg cctccacaag cacgtgataa tactcaaatg aaccgtgttc 2971081 gatttgggtg aaatcatagt tttccaaaat gttcagtgtt aataaaccgg taaatccctg 2971141 agaattcggc ggcgcctgat acacactgta tcctcgataa tcacttgata caggcgctgc 2971201 ccactcaccc cgatgcgctt taaaatcatc gattgtcatg taactgccgt tattctgtaa 2971261 atgtgagaca atccgctgag cgagatctcc ttcataaaat gcgcttcttc ctttttcagc 2971321 aatcaagttc agactgtctg caagctcttt ttgcacaaac cgctctcccg ggacaggtgc 2971381 tttgcccctt ctcgtgaaga tgtcagccgt gtaaggcgtg gaagccagca gttcaatatt 2971441 cttttctgtg tgacgacact gatcagctga tacaggaaac ccattttggg cataatcgcg 2971501 tgcgggctcc aatacatctg caagagacag acgcccgtac tccttcagga ccgcatccca 2971561 gctatcaacc attcccggca cggtaatagc actgtcaatt ccccgcagcg gaatcgcgct 2971621 ttttccctta tatacatctc tcgttacgtt ttttcctgaa cggccgctgc cattgtagac 2971681 ttttactgcc tttgtttcct ggtgaaaggt cagccaaaag gaatccccgc caagtccggt 2971741 catatgcggg tacacaaccg caagacaagc actcaccgca acagcggcgt caaacgcgtt 2971801 gcctccctta tccagtatgc ggtttccggc ttgagaagcg agataatgcg gactgacgac 2971861 catttgcttt gtaccgatga cagatttgtt catcacaagt cccctttttt aagaaatttt 2971921 cttcagtata gggagcctga tttttcacat ctactgatcc ggcagaaaaa ctgacgaact 2971981 ttcttctttt cgcaaataat aagatatttt cgcattcatt tcgaaaacaa atgaaaaatt 2972041 attatttcta tacgtaactt ttatgataaa atgattgcta aaaggctacg aaagcaggtg 2972101 gagcaattga gtcatgaata tcaaatcccc aaccttgtac ttgatgagac tgataaacaa 2972161 attctcacga ttttgcatga agaaggcaga atttcttata cggatcttgg caaaagagtc 2972221 gatttgtcac gggtcgccgt tcaggcccgt atcaaccaat taattgaagc cggtgttatt 2972281 gaaaaattca ccgctgtcat caatcccgct aaaatcggca tccatgtttc cgtgtttttc 2972341 aatgtcgagg tagaaccgca atttttagaa gaggtcgctc ttaagcttga ggaagagcct 2972401 gcggtcacca gcctttatca catgacaggc ccgagcaagc tgcatatgca tgggatcttt 2972461 accaacgatc aagaaatgga agaattctta acaaaacggc tgtatccatt gcgaggcgtc 2972521 gtcagtgttg attgccagat gctgatcaaa cgatacaaaa gccgtatggg aatgaagctg 2972581 taaaggagag aaacaaatga aaaaccatcc ttatcgggat atgacggccg caatggttcg 2972641 caccggcata ttagggttcg gcggcggacc ttccgtgatt ccgctgatcc gccatgaagc 2972701 ggtcaataaa tataaatgga ttgacgatga tgaattcgga gaaatattag caatcgctaa 2972761 tgcgcttccc ggaccgattg ccaccaaaat ggctgcttat ctgggcttta agctaaaagg 2972821 cacattaggt gcaattgtgg cgatcctcgc ccacattctg cctacatgtc ttgcgatggt 2972881 gggcttgttt gcggctgtaa atgtgttaag ccattcagca attgttgcag gtatgattgg 2972941 tgccgtcacg ccggtaattg cggtcatgct cggaatcatg gcgtacgagt ttggccaaaa 2973001 agcgcttaaa ggtttcggct gggttaccgg catcctgttt tttatcatcg cttttatcgg 2973061 cctgcaaact ttacagatta atcccggcct ggtcattatc attttcttag cttacggggc 2973121 gtttcatttt aaactgaaag acaaaatcac aaataaacat tcaaaagata aaggaatgtc 2973181 agcctcatga tatcgatcta tttatttatg gcgtttttta tcgcaaacct actgggatat 2973241 ggcggcggac ctgcgtctat cccgctaatg tttgaagaag tcgtaaacag atacagctgg 2973301 ctctcaaacg atcaattctc aaatatgctc gcacttgcga acgcattgcc gggcccgatc 2973361 gccacgaaaa tcgctgcgta tgtcggctac agcgcaggcg ggtggcccgg cttcctaatt 2973421 gccctgatcg caaccgtcgt accgtcggcg ctcgcattga tcgtcctgct gcgcatcatc 2973481 cagcgcttcc gccaatcacc tgtcatcaaa ggcatgacgc tgtccgtcca gcctgtcatc 2973541 gcggtcatga tgctcattct tacctggcaa atcggcgcag acggcatcaa agcgatcggc 2973601 tgggtccaat cgatcgtgat tacgggaatt tcgctccttg ccatgacaaa attcaaaatg 2973661 catccggcat ttttgattat tgcggcgttt ttatatgggg gccttgtgat cccttattta 2973721 tagaaaaaag cacctggaca ggtgcttttt tattttagcc cagaaatgcc gtttgatatg 2973781 acagctgttt cttctcctgc gtcactcttg atcatgtgct tgacttgcag cgtggttcct 2973841 gccattctca cagattgctt caactgggac gaattggttt caacttgtat ccaaacagga 2973901 ggctggacct tccaaaataa atagagtgca agaatcagca agccagcaat gaccgacagc 2973961 aaaaacttca tatcgcatcg cttcttttca gtaagcggct cgcagcggac agcgcctgat 2974021 gatcacgaag aatatcgcct ggacgattgc cttctcccag cacatagcct ttaaaggaca 2974081 ttcccataaa atgaaaaata tgttcgaatt gctgaatcag cggcagccct tttatttttg 2974141 gattgtctcc gcccactgct attacatatg cctgtttcac tgacatttgc tgtttaaaat 2974201 caggaaatct cggatctctc aacgtctgtg accagcgatc aataaacagc tttaatgtcc 2974261 ctgacatgcc aaaccaataa attggggtgg cgaatataag aatatggcac tgcaatatcc 2974321 gttcaatgat agaatcgtag tcatcttgaa caggacgaaa gccgccttgg gcgtgacgca 2974381 gatcttcaat tggttgaatt ggatatttct gcaaataaat gtgctccgca tcgaatcctt 2974441 gaacagcctt ctccgcaaga acatccgtat ttccgccaga ccgagttccg ccgttaataa 2974501 ccgcaatttt catgatgcat ctgctccttt gtttacgaat gattttcttc atcatataat 2974561 ggattcatca atcaatacag atgattattt cgattaatcc aatcgctaaa accgatttag 2974621 aaaggaagag aacaagtgga attgaagcag ctgatcacct ttattacggc ggctgaacat 2974681 gtaaacttca ccctaaccgc caaaatgctt aattatgcac aatcaagcgt tacctctcag 2974741 atcaaatcac ttgaagaaga aatcggaacg cctttatttg aacggctcgg caagcggctt 2974801 atcttgacag aagcaggaaa aacgttcaaa tcttatgcac agaagatcat tgcgttaaca 2974861 gaagaagcga aaatggccac aaatcaagta agagaaacaa ccggaacctt aaaaatcggg 2974921 gcgacggaaa gccagtgcac ataccgcctg ccccctatca taaaagaatt taaacaggct 2974981 tttccccaag taaagctcat attcaaacca tatatctcca atgaacaagc gaaagaacag 2975041 ctcttacagg gccagcttga tatcaccttc atcttggatg taaaccggat ggaagacgca 2975101 ctgcacgttg aatctttgat tcaggatgag atcaaaatgg tggctgctaa tgaccatcct 2975161 tttcctgcgg atttaccagt aacattgaag gatcttcaaa acgaaactct tctgctgaca 2975221 gaggacggct gctcgtaccg cacgctcttt gagaacaatt tgcatgactc cggtatctat 2975281 cctaacaaat tggaattcgt cagcatagaa gccatcaaac aatgcgtgat ggccggactt 2975341 gggattggaa tcttgcctga aatgacagta aaagatgata ttgcagcagg ccggatgaaa 2975401 gaactcaatt ggcagagcga ttgccccgtt ttcactcaat tagcatggca taaggacaag 2975461 tggatgtctg cgccattaaa ggcttttatc gatttgacac ggaaaacatt caaataaaac 2975521 ctctccacaa ggacgacaag gtttttgaga ccagggcaca cacatacaaa aaaaacactt 2975581 gatgacttag agccccaagt gttacacgtg atttttctga taaaacgttc gcaaaacatg 2975641 cgtctcaagg tcagccaggc ggacagggat cggcagcctg ctttcttgat tgatcaagct 2975701 catcgtgatc tgatagctgc tgtctaaatc aatataatta ccgcaagaca agaaaatagg 2975761 cttcacgtcc cgccgcgttc gcagcgcccg tccatatacc tcgccgtcaa tgataatatc 2975821 ggtgtatgcg cctacttcaa tttcaggcgt cacgaaatcg cagcctttga ttttgagata 2975881 ggttttcgct atcccaatcg tcggcttgcc cagaaaaaaa gccgcatggg tggcaacgcc 2975941 catatgattg taatgcagat atccgttgcc atcaaacaag aagacatccg gctccgtctc 2976001 cagctttttc gccgcctcga tgatcaaggg cagctcgcga aacgcaagaa aaccggaaac 2976061 atacggcacg ctgattctcc ccatgctgtg cactttttca atgacttctt ttgtatcagc 2976121 gtcaattacg ataatacagc acactccgta tggttctcca tcctgctccc aataggccag 2976181 gtcgacgcct gcgcaggtgt tgatggagtc tggatggatc gtgggggata ggttgatacg 2976241 atttttaagg ttaaattgca cttgtaaaaa gtcttgttcc tttttcatat caaatttatg 2976301 cacatcaaat accttcataa cgattgctca ctctcgacct aaattaatgt gagtctctct 2976361 tctcgattct agtatttcaa aatgaggact atctgtatct atctcgtact tatttaatag 2976421 attgccttct tcatcccaat tcttttcaga aattagtatg gaatgctcat actgttgctc 2976481 actttttttc ctgccatttt caaaccaaat tatgcttata ccgtgcaatt gcccatatcg 2976541 gtattctttt tcactttttt tattcccgtt ttcataaaat tcacatgtta aaccatgggc 2976601 cagaccattc ttatatttag taaaatagat gatttgacca tttggatata attcgtaagc 2976661 cagccctgta aacggctggc cattttcgtc ttcaggatta tctaaaatct catcacttac 2976721 cgaagagaac cataaatcct caaagtccac tcccttttct tttatactct tcatatcata 2976781 ttcattttcc atactttaaa gcctccggta tataatttgt attttgagtt atatattcac 2976841 aatgtggaca tctaggcatt gggacacctt ctggcatctt tttatttatt ttcctagcac 2976901 ttactacata taccattaaa tcttttaaat ccgcatcagg tctttgaagt aacgcttcat 2976961 ttagagcatt aacttcggca tgagaacccg cccctgacgt ctttatataa ccttctttaa 2977021 gttctgtagg catatttaca attctatcat gaataagtgg atgtagtacc ttaggtggct 2977081 tcccatctat attgtttatt ccaaaataat aattgcctgt ttttttgtcc aatacaccag 2977141 ctaccgcagg gcctctttgt tttttagtta gaccagaaga tttaattcta ctaagttcgt 2977201 ttagtacttc tgcccttaga tttattcgat ggtgaagatc ttctttagac aatacaccat 2977261 gcttatttct taaatattga agcctagttt gtttttcttc agtagtctta gcaatattgc 2977321 taataaggct ttcattactc actttattga catatggagc atttttttgg tacaaccgat 2977381 caaagtagtg tgccaatcct gctccaccaa taatagtaat agcttccagc gccccttgct 2977441 tccgcttctc ctcagacact ttgtttccga acatatcccg gcctgtgaca gcttctgaga 2977501 atccgtttga cgcaacaagg ccgtatgcgc ccatttctgt cattttgaga atgtctaagg 2977561 atttgcctgt tttgtaggcg tctaatgcgt gttcagcagc gatagctgct tttccggttt 2977621 tgtagatggc ttttccgcct ttgaaggccc ggcctgccca gccgacgact ggtatgaatc 2977681 cggcagcggc catagctcct gctgtcacac gctccgcggt ggagagtttt tctccggtaa 2977741 ccggatcaac gccttcggtt gctcttttat aatcataata gccagtgact tctccagtaa 2977801 agttgcaaac tccatcccat gttttttcgt accacggttt gtttgcttct tcctcggctt 2977861 tttcctggag ccgtcttgct tctgcttgct gggtttttgc atcgatatag gttgttcctt 2977921 gattttctac ttcaatgacg cttttgtaga cttcattgct gtggaaggct tttttgtcat 2977981 agtacatagg ggatgcgctc ttcccattgc tggtggcctg catgagaaca gaatatttgg 2978041 tgagcactgc gttgtccaga gattctaaat tttgatattc agtggtcagg gattcatcaa 2978101 gcttatcgac agctgtgatt gtatcacgtc tgattttttg ggcatcgccc atcttatctg 2978161 catagtcgtc aagcgtgtac atgtcgagat caataatatc gctgatgcct gacaaaatag 2978221 aatcgatttc ttctttatga gcggagacaa tctctgaggc tttcaggtct ccattgggca 2978281 gctcatgatc caaaaaagaa gtttccacat atgaatcatt cagttcttga tctttaatat 2978341 ctcctgaaat gccgtttaaa aacgcaattt gagcagagac aagcgtcagc cagctgtcta 2978401 cgatttctgc ctgtccctga aaaaaatctt taatattgtc cgcgccattt cctttaaaat 2978461 tatcgcctaa atcggcaact ccctgaaacg cttttttcag cgtattcagc tgctcttcaa 2978521 gcgtctcata ttgctttttt ctgctcttcg cttcttcgat taaagatttt gattcaaata 2978581 ctttactcat cgcactgccc tttctgttct attttaccgc tatcgcctcg tcctgctctt 2978641 tgagtgaatc tacgttatcc tttgtatcct cgatattttt ctgtaccgct tttttgtaat 2978701 ctccgagcat ggttttgatg ttctcctcac gctcatggta ttttttcgta taatcgaggc 2978761 tgttttttcc gttggatcct gcggcgccga ttgatacgtc agcaagcgca tctttgacag 2978821 aatctaatgt tttgatgact gtgtcgtact tcagcttaat ttctgacata aaaaaagatc 2978881 accaccattt tagtttacta attgtatttc cgacttcttc cgcgaactct tctccctttt 2978941 taagaagatc tgctgcacca tttgctatga acaattccga tgcatattta gctttatccc 2979001 attcaagatc aaaaattttc ccgttaatcg aagccatata ctcgttatat ttatcattca 2979061 caatcttaga tgcttccgat ttcgcctctt ctcttccctt gtcgaaatca tcggcttttg 2979121 ttcccgtcca atgcttgccc aattccggtt tcacaatttc tttgatttca gtgattgcct 2979181 cttcttgcag tgtgtctatg tccttttttg cttttttcag cttttcgatc ttgtcttcca 2979241 cgtctgaaat ttttccgttg agcgaacttt tgatatccgc tagcatactt tcataaccca 2979301 tctgaatcac ctcttaatac tcaaaaagtc gtatggaggg gctgatgaag atagactttt 2979361 ccatacttta tttccatata ttatatttta aaatagccag aaggcggctt aaatagggta 2979421 aatggcttaa tttaggcata taacgctctt gaaatgtagg tatttgatct tgtttttgtt 2979481 cgttatacag ctaataaaag cgttttataa aatgaaatca cctaatgtca tagttataaa 2979541 ggcacttgaa agaggcagat gttgttgatc tgcctctttc ggcgctgagc ttattgttca 2979601 tgtttatgtt cttcatctgg tcggccatgt ctgattttgt catttggctt ctattattcc 2979661 ccccttctga ccctttggat caaaagcttg tattagctgc agtcccagtt gtacagaacg 2979721 tttgaaaagt cttttttcct tagatcttca ggtgtgatga aaaaattggc gatgccgacg 2979781 tctccccaca ttgaatcgat atcatcgtct gaatcaattt gtaacagcat gatggtgtgt 2979841 tctttatatg cgtattcccg gggatcatgc tgggtaaaag aagcgtatcc gccaatttta 2979901 tggccaaatc cgttttcagc cagttcatta taaatgtctt cttcatcctc gccgaactga 2979961 ccaaagaact ccattgtttc catgcccgta tactgctcaa attgaaaatc tgtaggcagc 2980021 acccattccg aagatttcac aggctcgact gccgcttctg ataaaatcgg aaaatcacat 2980081 tcgcctgtgc caataaatga aaaatcagaa acaagctcgt catcgttttc tacgatattt 2980141 tcaaaataga tcactctgaa attcttttgt tcacatcgat cgtcaaaatt caatccatag 2980201 acgtcatcat gaacagaaat gtagaactgc aggatacctg aagaagggta gccgtcaagc 2980261 tggggaatgt gcgagaaatt aatctgcgcc agaagtttca tcggctgtcc attttcgtca 2980321 gtcggatatg tttcatgctt ggggaaatag ggatcaccgg caattttgct gtcatatcgt 2980381 cctgttttcc cctttctcac attcagtttc acgtattctt tcgctgattt ctccagcaag 2980441 tcgcggtacg gtctcatttt ttcgggcaga tgattcatca gattctctcc ttttccggca 2980501 tctccaaggt tttattttct ggttttcttc taatgttttt caaacgaatg tttaaagaag 2980561 ccctacttct gcataatttt ccaaacaata gttaaatagt agcaaatgta ttcagcaccc 2980621 cgcaatagat gaaaaaaaga ctggtgcgca accagccttt ctttttcatc tattgaattg 2980681 cacctgacgg aacaaccgcc ttccgtccga cagaataata ctccactcct gcagccaaag 2980741 cctcatccaa tgtgtagcag tttctgccgt caaatatgag cggcgtttcc atcaaatcct 2980801 gataagccgc taacgggaat tgtttaatgt cagcccagtc ggttaaaatc atgacggcgt 2980861 cagacccttt gacagcttcc tcgatcgtct ctttatattc aacagcttgc gggagaacat 2980921 gctttgcatg gctaactgca atgggatcgt aggctctgat acgggcgtcg agcgcagcga 2980981 gacggtctgc aataacaatt gacggcgctt ctctcatatc gtcggtattc ggtttaaatg 2981041 acaggcctaa aagggcaatc gtttttcccg tcaccccacc gagcctgttc agcgctttat 2981101 caaccagcat cgcctgctga ttgttgttga ctttgataac ggatttcagc agttcaaaat 2981161 catgctcgac attgccggca atttgcacga gggcgtttgt gtcctttgga aaacaagagc 2981221 cgccgtagcc tatgcccgct tttaaaaact ggctcccgat ccgcttatcc tgtcccatcc 2981281 cgtatgcgac tgcttcaata tcggcgccga ccttttcaca tatattcgaa atttcgttta 2981341 taaaactgat cttagtggcc agaaaagcat ttgaggcata tttgatcatc tcggcgcttc 2981401 tgatatccgt ttggtaaatc gggatttgaa acggacggaa gagctcctcc agcgtatttg 2981461 ctgttttctc atcggccgtc ccgatcacga tcctgtcacc atgaaaggta tcatagatcg 2981521 ccgacccctc acgcaaaaat tccggattgg atgcgaccga aatactgaca ggctccgcta 2981581 gatgttcagt aatcagtcca ttaatcaaat cgtttgtccc aacgggcact gtgcttttcg 2981641 ttaccacgac tgtatctcgt ttgacatgct ttgcgatgcg tttggccgca tctgtaattt 2981701 gctccagatt ggcgtgcccg tcgcttttct gcggtgtgcc gaccgctata aaaatgatgt 2981761 ctgcctgtgc caagcctttc tcatagctcg tttcaaagtt cagccgtcca tcagctgtat 2981821 tttttctcat cagctcttca agacctggtt caaatatggg ggaaatgccc tttctcattt 2981881 catcaatctt gtgagcgtca atatcaatgc aggttacatg atgtccaatc tcagaaagag 2981941 aaacacctgt cacaagaccg acatagcctg ttccgatgac tgttatattc attgtttccc 2982001 tccaacagtt aaattgctgc tttgcagctt ccgtaatatc gtatgagaac atcctatcat 2982061 gaatgcgaat gatctcccgc atagcctgtc gggtacagcc tgtacagatt tctgaaatgt 2982121 gattcaacca tacaatacac tattatatcg ctctcaaaaa gaaagtggtg aaatgagaat 2982181 cggctgttaa aaaaaaccaa acaattttct tcttttgacc ggctgcggag gctgtctgaa 2982241 gatggtctga ttccgcagga gaagctctgc attttccgtc agcatataag gaagttccga 2982301 gccgaattct ttctctagaa cataaagagc ctcttgagtg tgaaaatttc tcgttttcac 2982361 attatgggca tctgaggcta cgaaatggat caaattggct tcaaccagcc ggagagaaaa 2982421 tgctttcagc tgcttgccga agatccccgc aagacttcct gaagtaatct gagatgctgc 2982481 tcctttttcc acaagatgat acagcaagga cgggttttcg cgaatttccc tgttgcgttc 2982541 aggatgggcg ataaccggaa tatatccttt cagctgcaaa tcataaaaaa gctgctccgc 2982601 atatcgggga acgtgatcaa acggaaactc aatcaagatg tattttgtat cattcagcga 2982661 aagcagctga cgtttggcaa ggtcttgttc cacctcgccg tagattctga tttcctgtcc 2982721 cggaagcaca tgtaaaggaa tgtcttcttt gattaaacgt ttgtttaact gatctgctgc 2982781 ttctctgact gcggctggct cgtttttata cacaccgttg ttatgatgag gtgtcgcaat 2982841 gatcgtccgg attccctgac gaacagctgc tcttgccatt tctatgctgt cggccgaatc 2982901 acctgccccg tcatccattg cgggaagaat gtgacagtga atatcgatca tgtcctagcc 2982961 cccttttttc gcaaaaataa ataacgggca cgatgcacgt tatttatttt tgcatgaaat 2983021 tgtccttggt tccgtaatat ccgtattcag agtgcttcga aagctttttg ccgttcataa 2983081 tcgccccaag gagcttgctt ttgcacgttg caagcgcctc tttcgctttt gcggcttgtt 2983141 ctttttctgt tttcccgctt gaaataacca gaacagaacc gtctgccacg ttgcctaaaa 2983201 tctgtgcatc tgctacggca agaataggcg gcgtatcaaa aatgaccata tcatatgccg 2983261 cacacgcttc gtatgcaagc tccttcatcc acttcgagga gagaagctcg gccgggtttg 2983321 gcgggatcgg gccgctcgtc agcacgtcaa gatgtttttc attcgatgct tgtacagcct 2983381 gctccataga gcttttcttt aataaaacag atgttaagcc aaccgtattt tcaagaaaaa 2983441 aagccgtatg tactgttggt tttcgcaaat cagcatcaat caggagcact ttttttccct 2983501 gttgggcgaa tacgacagcc aggttggcgg ccgttgttga ttttccttcc cccggacaag 2983561 ccgatgtaat catgactgat ttcatttgcc ggtccactga agcaaattct atattcgtgc 2983621 gaatcgtccg atattgttca gagttcaagg atttcggctc tgtcattgca atgacatttc 2983681 tctgcatccg cgagcctctg ttttttctaa gcgccaaaat gtccactccc cgttttttca 2983741 gattggaaac cctgtaaggt ctttgctgtt ttctgctcat tcgcaatggt ggaaactgtc 2983801 cctaaaacag gtatgtccag caaggattcg agctgctctt ccgatttgat cgtattatcc 2983861 aaatgctcaa gcaggaaggc cagtccgatg cttcccgcca atccggccgc aaacgcgatg 2983921 gcaatgttta gtagcggctt tggcgataca ggggacgggt gttctgaaac ctcggctttt 2983981 gacagaatgc tgacattgtc aacattcata atggatgtga ttttgtcttg aaaaacagat 2984041 gctatagtat tggcaatatg agccgctgtt tccgcgtttt catccctgac tgatatgttg 2984101 accacttggg agtcctgttc gctggatacg gtaattttgt cattcagttc ttgggatgtc 2984161 atcgacaggc ccatttcttt aatgacttca tctaagatgg cagggctctt aatgatgaca 2984221 ttgtacgtat tgattaactg aagattggtt tggacatcgt taaattggac ttcttttcgt 2984281 tcatttttcg attggttgac cagaatctga gttgaatttt catagatggg tgtaagtgcg 2984341 aagaaactaa tgagtccgcc ggcagcagtg gcagccgcgg ttacaatcat aatcaaaagt 2984401 atgcgttttg ttaacgttga taatatctct tttaagcttg tagattctcc catgatacct 2984461 ccaaatctct tataacatcc ttttccatct acgattatac aacgttgaaa ccgcatttct 2984521 ccagcttttc acgtgacata attcgacatt tttttacaat gcgttatgtt agtacttttt 2984581 atgtaagcgc tatatttact gtgttgacag tgctgtctca ttttctctta ttcgggcagt 2984641 cacgttctct cgcataaaaa aatcccgcta aaggcgtgcg ggatttttat gttgcatatc 2984701 catttttaat atgagaaatc aaattttcaa gcatttcctt cgtcgtcatc tcagatgact 2984761 gctcaccaat ttcatgtgca tgcatcaaaa ttttcagaaa ttcttcttga ttcaatttct 2984821 tttcactcat cttttttttc ctttcagctt ccattaagtt gaaaacacga ttattatatg 2984881 atgctggtta tcaatttgca atctctaata catcattcga cacatcctat tttttatgtc 2984941 cttttttagg aaaaactttt taaggccgat gtgttgcgat ataatagaga aattggatct 2985001 ttttattacg tgactcggtt aggagcgata atcatgcttc agaatatgat ttccaaagac 2985061 gatgtgctgg catctgctga acagttaaaa gaacttcttc cttacaatga ggaaaatgtt 2985121 cagctgatca aaaaagccct tattttatat cggcaggatt cagtctatcg tttacaagca 2985181 gtgagtccga cggaagttac ggcttacgtg caggatgttg tgcctgtgcg ggtcacattg 2985241 aacttgtttg tcatagtcaa aagcggctgt tcatgtccgt ccggaagaat ctgccgccat 2985301 atgctggctg tgtttttata tgtatatgca atgttcgagc gagtgggtac ttttacagag 2985361 tattggctgg agagggaaaa gcttgaggaa agcaaagagc tcgtccgccg ccagtttcag 2985421 gaaaaggtgc tgcctaatga agaatcactt tcaagctggc ttgctttttt tgattcagag 2985481 ttttctctct ggcaggcacg tacgccagaa ggcagccaaa acatgcaggg cctctattac 2985541 ggctacctgt ccgcattaaa aaaacatgcg ccgaacaagc cggagctgaa aagcctgtat 2985601 cagattcatt ccgcgattgc ggtttggctt cgcatgttca cattgattga agcgggcaag 2985661 ctaaaccccg aacaagattt ttattccctc aatccgtacg ttgaacagct gatggataca 2985721 atctacagct ctattgataa attaaaaacg tacgcgctgt cttttgcgct tgatccgttt 2985781 ttggataaaa caccggatgt tatccggcat ttgctgttga aagaagaaat tttccaatat 2985841 gaacgcatcc gcgtcttcgg tgaaatttgg agtgcgctgc tgtcgcggcc aaaatgggtg 2985901 gcacgcgaac aggagatatt gaaaaaagaa gcaggacggc gtttttctcc cgaattgcaa 2985961 ttcgggcgcc tgcatttgga attcctgcaa aaaaatgatg acgttatttt tgaggaagcg 2986021 gatcaattcc cgccggaagc gctcccttat acattccaat ggctgagtga aatgactgcc 2986081 aagaaggact ggaaacggct taaaacatgg taccagcaaa ttgaaccaat tgcgatgggt 2986141 tatacgaagc tggataagcc gtttaaagag attcgcgatg tgatcggcga gctgttcctt 2986201 ctgttgaatg cctatgtgca gcaaaccaat gatcaagcgc tgtttgagcg ctttgccgcg 2986261 ggctgtctgc cgtatacgtt cacagaatac agccatcatt tatatgaaaa aaaacgctat 2986321 gccgagtgga ttgaaattca tagccttgtc ggcttttcca tcaatgaaat ggataaaatg 2986381 atgctcaagg aaattgcagc gagcgaccct gaggcgctta taccggctta ccatagagaa 2986441 gtggcttttt tcattgatca gaagaaccgt agctcgtaca aggaagccgc ccggtatttg 2986501 aaaaaattgc gcaccctgta caaaaaagcg aaaaagcaga aggtgtggga gcggtatatt 2986561 cagctgctga gctcgcatta caagcgcctg cgtgcgcttc aagaagaact gcagaaagga 2986621 aagttgattg atggcgagtc ttaaagaaat tctcatccac gtcgaacaaa tggaagatgg 2986681 gtcatttacg ctctcagcct ttgatgagaa tgagcagcct cttccctaca gccatatgaa 2986741 aaagcatttg ttccaatggc atgaatcctc attttacgga acctttctag aggatgtcag 2986801 cttcatcggg acgactgctg tccttctatc tccatggatg actgtagagc ttctcggcaa 2986861 aaactcgttc aactcattca gctccgtgca gcttacagaa gaaacggagc cgctgatcga 2986921 ggcggcatcg accatctatg aatttatcgc ggacggcgat tttatgcctg actatgacgc 2986981 atggacaaac ggtgtttttc gctggaagga ccgcgataat atactggaag gctttactgc 2987041 ggaatggttt tccgctgccg tacaggatta catccagtac gacgatgacc tgcgggagaa 2987101 atgggaacat atcaaggaaa aatcgcctgc ggttacgaca ttccgtggcc attttcttga 2987161 tgaagaggat tttctggaag gcattggctg gattgacgat caatctccat ttactgtcgg 2987221 cttgcgctta aatgaaccgg actttgacgg agacgaatgg aagatcgaga tgtttttacg 2987281 cgataaaaag agcggtgctg tagaattctt tgacggactg aagagcctca aaaaatcgtg 2987341 gcaggcgtac agcgataaaa tcgcgcgtga gcaggaccgc tttcacagaa cggttccgtg 2987401 gctgtcgttt gattccggga caacgctgat ctcggaggaa gaagcctgga tcttcctgtc 2987461 agaagcaagt gagacgcttg tcgatatggg ggtagaaatc ctcctgccgt cctggtggca 2987521 gattgtcaga gacagcaaca tgatgctgaa agcaaaggtg tcttcctccc cgcgcggcga 2987581 gtcatttgtc ggcatgaatg cactgcttga tttcaactgg cggtttgcga caaatggaat 2987641 tgaactgact gaggctgaat ttaatgagct tgtcgccagc aacaggcgcc ttgttaatat 2987701 ccgcgggcaa tgggttaaaa tcgatccgca gtttatcaaa cagatgaaac gcctgatgga 2987761 aaaagcagaa tcagagggac tccacatgtc tgatattctg gcgcgggagc taatggatca 2987821 gcaggatggc ggacttgagg attcggacct gattgataca tctgcttttg ccggcattca 2987881 gtttgatctg tctaaacagc tcaggtcact gattcgaaag ctcactgccg cggaaaacct 2987941 gccggagcac aaagtcagtc cttctttcaa aggaacgctc cgcccttatc agaaatacgg 2988001 catgaactgg ctgctgtttc tgcgggaaag cggttttggc gcctgtctgg ctgacgatat 2988061 ggggcttggg aaaacgattc aaatgatcgc ctatttcctt cacgtgaagg aaagcggccg 2988121 acaaaaaacg cctcatttga ttattgcgcc gacatccgta cttggcaact ggcagcggga 2988181 gcttcaaacc tttgcccctg atctgtctgt cgcgctccat tatgggccgc gccggccaaa 2988241 gggtgatgat ttcgccgcgc attatgaaaa cgcagacgtg gtgctcactt catacggtct 2988301 gtcacatgcc gatactgaag agctttcttc tgtgacatgg aacacgatct gccttgatga 2988361 agcgcaaaat attaaaaacg cgcatacgaa gcaatcacgc gcaatcagga agctgaaggg 2988421 gcttcaccat atcgcgctga gcggcacgcc gatggaaaac cgactgactg agctgtggtc 2988481 tatttttgac ttcatgaata aaggctacct cggcagtttg accggcttcc ataaacgcta 2988541 tgtgctgccg atcgaaaaag accgggacga aaagagaatc ggacagcttc agcaattaat 2988601 ccggccattc cttctccgcc ggacgaaacg ggatgaagag gtcgcgctta atcttcctga 2988661 gaagctggaa gaaaaagaat ttatccctct gtcagccgag caggcatccc tttatgagca 2988721 gctcgtcaaa gacacttttg accatatgac atccctgacc ggcatgcagc gaaaagcgct 2988781 gatcctcagc atgcttggac ggctcaagca aatatgcgat catcccgcgc tttatttaaa 2988841 ggaagagcaa accgagctgc tggccggcag atcagtcaag ctcgaaaaat tgctggaact 2988901 gatgacagcg atccgcgccc aaaacgaaag ctgcctgatt ttcacgcaat acattcagat 2988961 ggggaacatg atgaagcggc tgcttgaaaa aacgttcggg gaacctgtgc aatttttaaa 2989021 tgggagtctc tccaagcaag agcgggatac actcgttgag aaatttcaaa ggaaagaata 2989081 tccgacactg attctttcac tcaaagctgg aggcaccgga cttaatttga ccgccgccaa 2989141 tcacgtcatc cattatgaca gatggtggaa cccggcggtt gaaaatcaag cgactgaccg 2989201 tgcataccgc ataggccagg agcgctttgt ccacgttcat aaaatgatta cgacaggaac 2989261 aatcgaagaa aaaattgatg tcatgcttga atccaagcaa accctgaacg atcaaattat 2989321 ccaaagtgaa aactggatta ccgagctttc cacacaggag ctcgaagaat tgtttacatt 2989381 aagcgctaca gcgcaataat catgactaaa aaagctggct ctaaaagagc cagctttttt 2989441 ccgttcatag ccgtcacgcc gaatttccaa aaaatccgtt acgccggtta tcaacagggt 2989501 gcgcttttgt ggcagcacat atacttacaa caaatgtttc atcatatgtg cgacaccgtg 2989561 ttcgtcattg gttaaggtga cagcatcggc tatcgatttg atgtcttccc gggcattgcc 2989621 catcgctaca ccttttcccg cagcctccag catcgatttg tcatttaaac tgtcacctac 2989681 agcagcagtt tcctcgagcg gaatattcag ctgttttgca agcctcttca gcgcctgccc 2989741 cttggaagct ttgcgggaag aaagctcaaa gttgtgctca gccgaactga caagcgtcaa 2989801 atcttcggca tgctcatatc ttttccagcc tgcctcaagc ttttctttga agaaagaaaa 2989861 gccgagaata ttgtaaaaat cgattggctc atcggcttca aacagctctt gaaaggagtt 2989921 aatgtaagca aagcccgatt ggctgtattg cacctcggcc gcctgcttaa ggacagaaag 2989981 atccgcttcc ggatttgcgc ttctgaatct gtcgagctca acatcaagaa gttctctgcc 2990041 gttttgcggc gtataaatcg ctgaacctgt gaatacctca taataatagt tttccgactc 2990101 aagccatgag agaatgtcat acgcccgttt cttatcaatc gtttcgtgat gataaagcct 2990161 gccctcggga tcgtgaatga cggcgccgtt tgcactgatg acccatgttt tgatccccag 2990221 cggttcaaag attgacatga cgtcaaaatg agcgcgccca gttgacacca ccacttcaat 2990281 gccgtcccgc tgcgcctgcc gcagtgcgtt ttcattttcc aagcttacct gatgcttgct 2990341 gttgagtaag gttccatcta agtcaatcgc aattaatttc acgtttgtca gtcctttcct 2990401 tcatcctgct ctgtcacgag aagctcaacg ccgtttcggt caagcaagtc acaaaatgcc 2990461 tgattcggca gcctgtctgt aatcaagagg tcgatttcat tcagctccgc atactgataa 2990521 aaactggtgc tgcccagctt agaatggtct gcaagcgcaa ttacctgctt tgcctgctgt 2990581 atcattttcc gcttcaccat gccatcctct tcatgcgcaa ttgtaatgcc atgttcggaa 2990641 atgccgacca caccaatcag cgctttatca acatggtagc ttgagagctt ttcaatcaca 2990701 gaggacccgt acagaaagcg gtgctccttt tccagcttgc ctcccagcag ataaatttca 2990761 attccctctt tatcggacag cacatccgca agattaatcg aattggtgat tacggtacaa 2990821 tcaaccgcat tcaaatgctt tgcacatgcc tgaacagttg tagaggcgtc taaaatcacc 2990881 cggtctccat catgaataag cgatgctgca agcctgccga tcttattttt ttcctcagac 2990941 actgttttca ggcggccgga atagctttga attttctgat gcacagtcgg taaaatggcg 2991001 ccgcctcttg tgcggatgat ggcattctgt tcctcaagtt tcacaagatc tcgtcgcgct 2991061 gtatcccttg acacttgcag gagcgtacag atctgctccg ttgtaattcg gttatgctgt 2991121 tttaaaaaat ccaaaatcgc tactaatctt tcttcttggt acacgccctc attccttttc 2991181 tcagcaatca tttataagta attataagtt tttatttgat tttattcaac attaataagt 2991241 gattttaagt aaaaatgcgt cgagagaacc aatttttcct aagtaggcaa aaagaaagaa 2991301 ccagtctggt cgactggtca attttgaggg gatgatgcga agatccggat aatagtgaat 2991361 ggatagataa cgggaggagc aggggtgtca atcagcagct ttttcccggg gtttagggtc 2991421 cataaaacga acagtgtcag ccaacacttc tgttacatac acgttaacgc cttcctcgtt 2991481 ttcatagctt cttgtctgaa tccgtccgct tacgccgacg agagaacctt tttggcaata 2991541 caacgccgtg ttttcagctg tttttctcca aagtgtgcaa ttgacgtaat cagcttcgat 2991601 ttcacctgaa gcattcttga agctgcggtt caccgcgagc gtaacatgtg caactgccgc 2991661 accggcggaa gtgtagcgaa gatcaggatc ttttgtaaga cgtccgacaa gcatgacctg 2991721 attgaacatg cgattcctcc tctccttgcg gttgtatgta ttgtaaatga tgcaacaaga 2991781 aaagaaaaac gcttaaaaat ggctttcagc ctctgttttt atctttcgtt ttcatttttc 2991841 cttcagctaa aaacatcttt tgcttttttc ctttgaagaa atatgtactt tttaaaaaac 2991901 ggaaaaagat ttgctttgtc agccagtttt gcgtattcat gcgcacatag gaagagccat 2991961 cccacgcaaa ccactgaaag ctcaattttt tttccggcat tgacagcttg attttatact 2992021 gctccatgcc atcttgtgtt tcgtataaaa aacttattct tccttttttg ttcagatgaa 2992081 cctcaaacac ttctttacgg cttaacatat atgttacttc cttttgaatc aaatgacttt 2992141 cagaaggaac gccgtcaata taaatttctt ttaaacgaaa ttgattcata ccacatctct 2992201 ccgtaatcca tagtcagtta cagtataatg aaaaaataga aattattaaa tgtttcgctc 2992261 atacaaaatt ctttagcccc aacattgcag gattttttcc tcgaaaacgt ttatgttata 2992321 atggaaggca agaaaacttt ggaagtaatc ggggtgagaa gaaatgaaaa cctttaaact 2992381 ggttgacctg aatgtggaac gagtggacaa ggaagaacaa tcaattgaac agtttcccct 2992441 tattgacgga ctgattataa ataaagaaga cggtgaaaat cactggctga ttgaggcgct 2992501 tgtacagaaa gaacatctgt ctttttttga acagcttcaa aacagccaat ctgaagccaa 2992561 agtatttgta acgatcacga aaaaaagcaa tcgccccgcc cagctgacag cagcagtgaa 2992621 aaatatcgtc aagctggaag aaagcattca ggttttactc tacggacaaa tggtcacaag 2992681 aaaacagcag ggcactgaaa ccattctcga gtcccttgta aaagagggct atacaggaac 2992741 aaaactcatt gaggcattta agcaaaaatt ataaatatga gggggcatgt tccccaaaac 2992801 agactcagaa ccgaagagca tcacaataga catttagaat agatatgttc tgcatgaaaa 2992861 aagctgccgt tttgaacggc agcttttctc ttcgtgcttt cactcttgca tatttaattt 2992921 gtatggccaa aagaatcaac caattcccct ttcacaacga ggcgcccttc ggttttgacc 2992981 gccttgtcac atgtgattaa cgtaatctcc tttttgtttg tctcctcaac tacatctgca 2993041 tccatttccg atatgatgtc tttcgatgtt acagaataga tataatcctt tttaaaatcc 2993101 gtgatgacaa tttgggcacc tgtttttatg ttttccagag gtccgaacag aagattcttt 2993161 tgcttcaaat gatggcccgc caacggataa tttccctcac ccattttttg atcccggcgc 2993221 attgttgccg cccctatcaa aagattttca ttggttgtgc cttttacgat cggaagctcc 2993281 agatcgacac ttttaattgt tatccgccgc cttgattgtg aagtaaaaat aagtatattt 2993341 cacgtgcttt cgacgttctc cacttgactg gaatgcttta atggcgatcc cggcatctgt 2993401 agcttcaggc tttccttcag aggaatcaga aatctcaaac tctattttct cagtgttcag 2993461 cacataaccg gctggcgctt tcgtttcaac aaaagcgtat tgtcccggtg caaggcctga 2993521 agctgtgact tgatgatgcc ggatatgact ggtttcgaag tctgtatgaa aattcgcgaa 2993581 cgattcagca tggttgatct tccggttctg atcattacag ctgccattat cggccatgac 2993641 aaatacaagg cttttcatgc cggagcgaat gacattttgc aaaaacccta tcattactct 2993701 gaatttatgg cgcgtattca aaacctgata atgatgaaac atacagcaaa tcaagccaca 2993761 agaatggaaa tggcgtttct ccagtcgcaa atcaagcctc attttcttta taatgtatta 2993821 aacacgatta tttctctcac tcatttggat attgaaaagg cccgggaggt aacagaggaa 2993881 tttaccaact atttaagaat gagttttgac tttcaaaata catcagccat cagttccttc 2993941 agacatgagc tttcgattat caattcctat ctttctatag aaaagacgcg attcagtaat 2994001 cggcttgagg ttcttttcga tatagatgaa gacattgact ttatccttcc gcctttaatg 2994061 attcagccct tggtggaaaa tgccgttctt cacggtgtca gcaagaaaag aggcggagga 2994121 tggatcaaac tgacagctaa aaaacaaagc aaaaatgagt atcacatcaa agtagaggat 2994181 aacggtcccg ggataactcc ggaaaaacaa atagatctct tatcaacgga ttttgatcgc 2994241 agcgtcggat tgaaaaatat caatcagcgg ctgaaacatt tttgcggaag cgagttgatg 2994301 atcagcagca ctccggatgc aggcacctct gtctcaatgc tcattcatct cgctgaaaca 2994361 acaggaagcc ctaaagaact gaaggacaca gaacgaacct aaacgaaaat tgagataaaa 2994421 aaagacgccg tttctaacgg catctttttt attccggcga ctttgcttgc tgcttcagca 2994481 ggtctctgat ttctttcagc agctcctcct gcgcatccac cgcttcctcc gcagcctctt 2994541 cttctgcttc ttttttgcgc cttaacccat tcaaagtccg aatgacgata aaaatggaga 2994601 acgatataat taagaagttc acaatcgtct gtataaagct gccatatttc actacagcat 2994661 cgccaaacgt aaacgacagg cctgaaaagt caagccctcc cagcagcaaa ccgaccaaag 2994721 gcataatgat atcatttact agagatgtga cgatctttcc gaaagcgccg cctatcacaa 2994781 caccaatcgc aaggtctacg atattccccc gcatggcaaa ggctttaaat tcattccaca 2994841 tacaatcacc tgcttttcta tatttgtaaa gaaaaaaaga caaatgtgcc gctggccatc 2994901 tgcctttttt caattattct ccgagggcaa aagtcagttc tacttcgcaa acgacttcgc 2994961 catcaactgt ggcaacgcct tttccgcgcc cgattgtgcc gcgggcacga atgatttcaa 2995021 cctcaaggtg aagctggtca ccaggcttga cttgtttttt aaagcggcag ttatcaatgc 2995081 ctgcaaaaaa agccagtctg ccgcggtttt cttctttaat caacatcgca acagctccga 2995141 cttgagcgag tgcttctacg attaatacgc cgggcataac cgggtactga ggaaaatgtc 2995201 cgttaaagaa ctcttcatta gcggttacat ttttatagcc ttttgcccgt ttgccctctt 2995261 caacttccgt aatccgatcc acaagcaaaa acggataacg gtgaggaata atttctttaa 2995321 tttgctgagt atcaagcatt gtcttgacat ctccttcatc tgcattagta tgtatagcaa 2995381 tcatcaaaga tccaatctgt acatttgaaa agtatattat gaattaatct ctttttcaac 2995441 cgcgctaaaa tgtaaccaac tgtcaatgag agccgtcaaa agttatgata tgataattat 2995501 agattttacc aatagcaaag aggtaggaaa atgatttcga agtttattga aaaaagaatg 2995561 ctaaacatgt tagacgagtg gtattccgca atgagcaaac gcaaaatgaa tcacgtttgc 2995621 acactgaaag agaaaattga tcagcacctt ccaaagatca aaaagaacac aaaactttgg 2995681 atgcgttatc aattgtttca ggcccgccat cagctgcttt ttgaaaacca gaacggactc 2995741 gattcattgt tcgatggcct atatggcctg gaagacaaaa tggatgatga attgaaatat 2995801 tatctgtatt ttttctctgg gttatatgag atggtaaaaa cagctccgaa acatgcagta 2995861 catcatttta aaaaagctga acagtacctg gccgccattc acaatacgtt tgaagccgct 2995921 gatttatatt atcaaaccgc cggcgcctat tacttgatga aatcaccgcc gctttccgtc 2995981 caatacgtca aaaaagcatt acacatctat ttgcaccaat tcggctatat caaaaaggta 2996041 atcacctgta aacttttgct cgccgtgaat tatattgatc aagaacgcta tgaaaaagct 2996101 gaacagcttt tcaaagaaat cattaagaaa acccagcaac tacatgacga aaacctgcta 2996161 tgccacgctt attataacct tggcttttta aaagcgaccg agaaaaaaga ccaggaagcg 2996221 cttctttact ttagaaaagt attaaagaat caagaatttg aaatgaattc accagtctca 2996281 tatcttcatt gtgtgtacga gtctgtcaga gcgcttttta aaacagggaa catcacagaa 2996341 gctaaagccg tccttcaaaa aggaaaagaa ttatctgaaa aggtagacat tcaaaccatt 2996401 tatttaaaat taaaaacgct tgaagccctc tacacatcag ccgaagaccc ttatgagcag 2996461 ctgctcgaat atgtgcttga attagaaaaa atcgaggcgt gggtggattt agaagtgctg 2996521 ttagaagata ttacggaata ctacaaaaaa aaggacgatt tcgaaaaagc cgcttttttt 2996581 atcatgcgcg gctgattgaa aaacgcccat tttcttatta tctgactgaa ttgattaaac 2996641 cgagcatttg atctcccatt gtgatcgttc tgctgttcag ctgatatgaa cgctgggacg 2996701 tgatcaaatc tgtcatttgt tctgaaatat cgacattgga catctcaagt gagccctgct 2996761 gcatgccgat gttttgtcta ttagcgccgt tcagctcttc aaaagctgcc gcattatcaa 2996821 tagagaaaag gttattccct tcggatttca gctcttgagg gttattcact tggacaacgc 2996881 caagattaaa ccgctgaacc gcgtttccgt cagatgcggt taaggtgccg ttcttattaa 2996941 tggtgatatt cttcattgag ctgtcgatgt tcactgtatt gccgttctca tcaagtacgg 2997001 gatacccatt tccagtgacg agctgcagct ggttggcatt cgcagcggac ggcgttacat 2997061 acagcgcccc gtccctcgta tactggcggt ttccatttac atttacctga agatactggt 2997121 atggagacgt aaatgcgata tccagatcgc gatcggtctt ctgaatgctt ccttgatcag 2997181 agactaggcg tgaactcatc atcgctccga cgccaaggcg caagccgggc ggcgtttttc 2997241 gggcttttgc cacttcctcg tttttttcat caacctgatc gaattgctgt ctgacaagct 2997301 cagaaaaatt cgtatctttt gccttatagc cggttgtgtt gctgtttgaa aggttgctgc 2997361 tgattgtgtc aatctgctgc tgcagctggt ttaaggttgt tgatgccgtt agcattgacc 2997421 tgagcatagt tgatgtcccc cgtttttttc ttccgttttc ttaaattttt ccaatttcat 2997481 ttgctgcttt atccatactt ttatcgtaag cctgaataac cttctgattc gcctcaaacg 2997541 atctgtacgc ttcagtcatt tctgtatagg cgcttgtcac atccacgttt gaaagctctg 2997601 agacgccttg ttttaatgaa taggctacct gattatttcc ggctgcgctt ggcagatcat 2997661 taccgtccgc cgtgctgtac aaatcatttc cgtcccgttt gagattgcgg acatcttccg 2997721 ccattctgac atcaatctgg ccggctgtgc gtccgttcgt tgtcacagta ccgttttcag 2997781 acacagtgaa attctcatta tcaacagtga ttggctggcg atccgtcgat aaaatagggc 2997841 gtccgttgat cgtcagctga ttgttctcat ttagtgaaaa tgtgctgctt tttgaataac 2997901 ggattccatc cgctgtttga accggataaa aaagagcagc tttttcattg gtttccgcac 2997961 tcatcggaac ttgattttcg atcaatgcaa tgtctgtagg ctggtctgtg gacttcaggc 2998021 ttccctgtgt aaagagaggc ttgagctcct gcatatatac tccggtattc acggaaccga 2998081 tttccgtcct tgatgtcccg gccggagatt ttgattctat tctgctgagc agcatctcag 2998141 ggaacgcgcg catagagcct tgatcagctt tatatcctga tgtatttgcg ttagcaatat 2998201 tatttgaaag catttccgtt cttcgctgct gggcaatcat tgcggatgtt gctgtatata 2998261 atccttttaa caaatttccc acctctaaaa atggcatttt ttccagttgt catataggaa 2998321 cgttcgttct ataataaaaa ctcagtattt tatcctatta tcgtcattta acatcttttc 2998381 gtgaaggctt tttcataaaa aaacctcatt ctttttcaga atgaggtttg tgaaatcagc 2998441 ttagtttgcg tttaggaagc ttgtccatat tatcaagcat gacacctgtg ccgatggcta 2998501 cgcaatccat aggattttca gcaacgagga ccggtacctt cagctcttca gcaagcagct 2998561 ggtcaaggcc gtttaagagc gcgcctccgc cggtaataat aacgccgcgg tcaataatat 2998621 cagcagaaag ttcaggcggt gttctttcga gcacttgttt tgcagcctga acaataacag 2998681 cgacagattc acgaagggct tcttcaactt ctttactgtt tactgtaatt gttcttggaa 2998741 gaccggaaac catgtcccgt ccgcgaatgg aaatttcctc gtgacgtgcg tctgggaaaa 2998801 cagttgcgac tttaatctta atatcctccg cagtacgttc gccgatcagc agcttgtact 2998861 cgcgtttgat ataatttaag atttccatgt caaacttgtc cccagccatt ttaatagaag 2998921 aggaggtgac aatatcgccc attgaaataa ccgcgatatc cgtcgtcccg cctccgatgt 2998981 ctacaaccat gttaccgctt ggctggaata tttccatacc cgcgccgata gcggcaactt 2999041 taggttcttc ttcaaggtac acatgtttcc cgccgctttt ttctgcagct tctttaattg 2999101 ctttttgctc aacggatgta atattcgtcg ggcagcaaat gagcatgcgc ggctttgaga 2999161 acaggccttt tacattcagc ttgttaataa aatgtttcag cattgcttct gttacttcaa 2999221 agtcagcaat aactccgtct ttcagcgggc gaatcgcaac aatattccca ggtgtacgtc 2999281 caaccattcg tcttgcctct tcgccaaccg ccagcacttt gccgctgttt ttatcaagtg 2999341 caacaacgga aggttcattc agaacaattc ctttaccttt aacatggatc agtacatttg 2999401 cagtaccgag gtcaatacca atatcccttg caaacatcta tttatatcct ccttgaaaat 2999461 ctgtttcaca gtaaatatcc acattgtgcc ctaattatat atattatcat aaaatataga 2999521 aaaaaagttg gaagcacaat aagttcttta caaatttttg cggatgtttt atgaacgatt 2999581 tcaagaaggc aatgccaggt gattacgatt gctgaacagg ctctccttcg agaatttcat 2999641 cttttttata tttgagcttt gtcgcttctc ctcctcttaa atgcctgatg gatttatgat 2999701 aatcgagtat ttctttcact tcgtttgcca agtcggggtt aatttcaggc agacgctctg 2999761 ttaaatcctt gtgtactgta cttttggaaa caccaaattc cttcgcaatg acacgaacgg 2999821 ttttctttgt ctccacgatg tacttcccta tcttgattgt tcgctctttg atgtaatcgt 2999881 gcacaccact cgacctccct aaaatggatg tgagaagtgt gaaatgagat ccgtattctg 2999941 taaagagtcg ttcattatgc cgcttcttcg ttgtatggtt ttaaaagtaa gtttgtgaaa 3000001 tatgcccacg atccctcacc tcaaacactc tctttgttag gtttgtaaca gtgtattagc 3000061 attcttttgg gaatatgcta aaaactcaat aaggacaagg ggtgaaacga actttttcag 3000121 attcagcaaa ctatttcgcg tcactaaatt ttcatcttta caactattga tcgctcctgt 3000181 aaaatgaaat aagcaattag ttacttaggt aagtttttta gaaggagacc gacatgtcct 3000241 acgtcaacag acacctcatt catcaaatca accaaagcgc ccgcctgatt gccaagaaag 3000301 ccaatgaaca gctagagcca ttcggccttt attcatctca atggtcagtt ttatattgtt 3000361 tgcgtacgat cggaccaatg actcaaaaag agatttggtc ctatttaaat gtggaagcgc 3000421 cgactgtgac tcggacgatc aaacgcctgg aggagaacgg ctgggttcag agacggcaag 3000481 gtgaagacaa acgggaaaaa cttgttgtcc tcacaaaaga agccgagaaa aaatacgaag 3000541 aaatcaatgt gaaaatgttg aaattcgagg aagagctgct tgcagatttc cgggatgaag 3000601 ataaagaagc tttttctcat ttattccgca tgtttttaca acaatgaaaa taaggaagtg 3000661 acatacattt gaaaaaagcg gatgcgatat ggaccaagga ttttattatg gtcctgcttg 3000721 tcaatttatt tgtgtttgtg ttcttttata catttttaac tgtattgccg atctatacac 3000781 tgcaagagct tggcggcaca gaatcacaag gcgggctttt aatcagcctg ttccttctgt 3000841 ctgcgatcat tacacggcct ttctccggag ccatcgttga gcgtttcggg aagaaaagaa 3000901 tggcgattgt atcaatggcg ctcttcgccc tatcatcttt tctgtatatg ccgattcata 3000961 acttttccct gctgctcgga ttgcggttct tccaagggat ttggttcagc attttaacga 3001021 ctgttacagg tgcaattgcc gctgatatta ttccagccaa acggcgcggt gaagggcttg 3001081 gatactttgc catgtctatg aacctcgcta tggcgatcgg gcctttcctt ggcctgaatt 3001141 tgatgagagt ggtaagcttt cctgtattct ttacagcctt tgcgctgttt atggttgcgg 3001201 gcttacttgt ttcgttcttg ataaaagtgc cgcaaagtaa ggacagcggc acgactgtat 3001261 tccgttttgc gttctcggat atgtttgaaa agggcgcact caaaattgcg acggtcggtt 3001321 tgtttatttc tttctgttat tcaacagtca catcatatct gtctgtattc gccaaatcag 3001381 ttgacctttc ggatatcagc ggatatttct ttgtttgttt tgcggtgaca atgatgattg 3001441 cacgcccgtt cacagggaaa ttgttcgaca aagtcggacc gggcattgtc atttatccat 3001501 caatcctgat tttctctgtc ggactctgca tgctgtcctt cacacatagc ggcttaatgc 3001561 ttctgctttc aggggcggtt atcggtcttg gctacggatc aatcgttcct tgcatgcaaa 3001621 cattggcgat tcagaaatct ccggctcacc gctccggttt tgcgacggca acgttcttta 3001681 ccttctttga cagcggaatt gctgtaggat cgtatgtatt cggattgttt gtagcatctg 3001741 ccggcttctc tgccatttat ttaacagcgg ggctgttcgt tttaattgct ctgcttctct 3001801 acacgtggag ccagaaaaaa cctgcagagg ctgaaggaaa agtgtctatt gcagaataac 3001861 ttgtcagact gccgggaaat cccggcagtc ttttttccat taaaacacgg cgccctctcg 3001921 gttgaacgag agaacgccgc ttatagcaat tattcaatga caggccgcgc aggtgaatca 3001981 ggatctaacg aaaaatcata ggacgcttca tcacgaaaca tcggatcggc atatatggat 3002041 tgttgatcgt tttttgttgc ttttcgatac gaagaaaatg aatcatattc tttctttttc 3002101 cacatccata tgccgtcttg atccgcttcc ttgtggtaca cgttatgatt gaccgtatta 3002161 ccttcgtttt ctgtaaagtc gtttccgata aataatctgg aatcaccggc cgtcaatata 3002221 ttcttttcaa ttgtgttgtt tttcgtatcg tactgcagca gcagctgtcc gccgtacagt 3002281 ccctttgtgt cattccggta cataatattg cgggcaatca gagaattgct ggtgccgccc 3002341 cgctttttgt catatcctcc gattgaaata ccggtgtacg cattgttgta cactttgttg 3002401 tctgtgatct gaatggcatt tgcatacttt cctttgtgtt cagacgttgc ttcaatccca 3002461 atatcgttat cgtaaactgt gttgttctta atttcgatat cgtgtcctcc atcgacataa 3002521 atcccgcccg ctgagtattc atctccataa gcaggattgc cgtaagtcga gttttgataa 3002581 actgtattgt tttctacgac tccgtttcgc acgtaatcgt ttttatccgc ggttccctca 3002641 taaccaatta gatcaatccc gatgttatta ttgttgcgga ccacattgcc tgcaactgtg 3002701 aagccgtcga tattaccgtt cagcacaact gcttcactcg ctccaagcgt cagtttctca 3002761 actgtattgt cctcgattcg gatgtctttc atgctgccag tcccataaac tgcgattccg 3002821 tgagcatttc cttcatccgc tgttgtctta atcccccgga tgtgattatc cttaatggcg 3002881 atatgactgc tggaccctga tacataaatc cctatagcag ttgcttcctc agatgaaaca 3002941 gaaagatctt gaattgttaa accgctgatg gcaatgtcat gtttatcgtg aatacgaata 3003001 agcggtgttt catattcagc gttcgcaacg gattcaccgc taatcacgac gttttcattt 3003061 tcatagtttc ggaatgtgat aggctttccg tccgtaccgc tgtgctttac atcaagggtc 3003121 tcatgatacg tgccctcccg aatcatgaca gttgtgccgg cagcagcctt ctcagatgcg 3003181 tgtgccaatg tacgaaacgg cttttctttt gttccttcat tttgatcact gccatttggc 3003241 gaaacataca gataatcccc agatccttcc tcattcgctt ttgtcttatc ataaacgaaa 3003301 gcgaggatga cagacgttaa aacacccgcc aaaagaataa aataccattt tctcattttc 3003361 gattcccatt tcgttttaga atagatttct aaaaccatta taaatgttct atttatggaa 3003421 aaccatttca aaaatatgaa aatataccgt ctaaatagat cttattcagc ctggcggacc 3003481 tgcgcatgtt caactgtttc aattgccaat gatgcaggcg ggtgaacacg catcagaaca 3003541 atgtagaaaa gaaaggaaat cagcacacct acaaaccaag aaatatcgta taagctcttc 3003601 aatacaggaa catacatgcc aatcagcgaa atcagcgctc ctaacattgt ggctgcaaac 3003661 gcacggtaat tgtagccctt ccaatacaca taccgtcctg tttcggaata caggtcatct 3003721 accgagagct cacgtttgcg aatgataaaa tagtcggcca tcatcacgcc tgccaccggt 3003781 ccaagcatgc cgcctattaa gccaagaaac gcatacacgc ttgtcgcgct ctccatcagc 3003841 ttccacggaa ccgtaaataa agcgagcaac gctgtgataa agctgccacg tttgaaattg 3003901 atatatttcg gcagggcatt cgctatatca taagcgggtg atacgatatt cgccgcgaca 3003961 tttacagaga tcgtggcgat gcagagtgtg atcacggaca agacgatgac ataagggtta 3004021 tcaaaccgcg ccaaaatatc gacaacatcc caaatcggct ctccgaacgc gacctgcgag 3004081 ccggaggtca ccgtaatact tgcgaatgcg aacagcgcaa acgttcccgg caaaccgtaa 3004141 aattgtcctt tgatttgctc tttttgtgtt tcagcaaacc gtgtaaaatc aggtatattt 3004201 aagatcaatg tcgcccagat gccgatgatg ccagtaactc cggcagcaaa cggccagaat 3004261 gtttctgaaa acgtatgaaa ctttcctggt tgagagtata tcgggcccaa tcctccagca 3004321 atatcaacgg cccaccatac catgccgcca aataccagat acactaaagg ccctgcccac 3004381 acctcaaaac gtttaatcga ctccatgccg tgatgcaata cgagtaaatg aatggcccaa 3004441 aagaatacaa aggaaagcaa accggacaag tgaatgccga gaatgttcca ctcgccgcca 3004501 atttctcccc aacctggcca catattcaaa agcaaaatgt tcagtgccgt gctacccgca 3004561 aaggtctgga tgccaagcca catgatagct gtaaacgccc ttagaagcgc ggggatattc 3004621 gcgccgtata tcccgtaaga agcccgaatg atcactggaa acggcagccc gtattttgtc 3004681 cccgcatggc cgtttaaggc aagagcgcca aataggataa gtgatgccgt aataatgatc 3004741 gccagcacct gccaaggcga aaggccgatc gcaattaatc ctcccacggt cgcgtaggtc 3004801 ggtatgttat gtatacatcc catccaaatg gaggcaaagt tcattgcttt ccacgtccgt 3004861 ttttcctgtc ccaaaggcac cagatcttca ttgctcagcc tgttggattg ctgctgactc 3004921 tcttttaatt tcatagccgg ctcccctttc catattgtct atatgtcgtc acacgttatg 3004981 ttttttgaca ttagatgtca cttaatataa ctgaagagtc agacaataac actggctatg 3005041 atatacaatt ttcccgtttg tatttgaaca gcttaaacaa gaaaaagaga cagacctcag 3005101 agcccgtctc tttcttaaga tgcagttttc attaatgcag caaatctcac agccattaac 3005161 aggcttgctc cgcccgctat aatcataatg attcccatca tatcaaaatg ggctgccgtg 3005221 atttctttac caaaaagaat gccaaggatc accgaagaca aaatcgatcc taggtaacgg 3005281 caggtttgaa acaggcctga agtcgttcct accatgttgg aaggactcgt ttccagcatc 3005341 gctgcctgaa gcgcgacatt gcccagtccg tagcctatac ccaagagcga cagaatgagg 3005401 cctttaccga tggtctggac attgataaaa aagatggtta agagcacggc tccagccgtc 3005461 atcaaaagcg ctcccgcaaa gatcggcttg acgacaccag atcggtcgat ccatttgccg 3005521 gttagaggtg acacaacgat gctcattcca gacataaaca gcataaacag gccgctcgtt 3005581 tgaacagaaa gatgcatttc atcctgaaag taacttggca aaccaaaaaa taaacaatag 3005641 aagaaaacat tcaataaaat aaactgaaca tacacggctg acaggtttcg ctgtgtttta 3005701 aacagacgga catcaataaa cggcttatcc gttttcagct cgcgccagac aaacgcacag 3005761 agcagaagca agccaagcac accttcaacc gcatgcggcg acgtgctgaa cgacagcaaa 3005821 aaggatagaa ggaaaatgat tcccccggca aataaaacaa ttccaagaat atcgagctgc 3005881 cgaataatgg ttttgattcc tgcccctttt ttctgatctt tcgggaacat atacaggccc 3005941 aataagaagc tgaggataat aaacggcaaa ttaacgataa agatcgccgg ccagcctccc 3006001 catacaatca aaaacccgcc ggctgtcggc cccagcgccg tcatggcgga cgcaaaaata 3006061 gagagtacag ccaaggctga agcttggcgc tcatgaatat gattccgaat caagccgaca 3006121 cctgacggat aaatcgcact gctccccacc gattgaaaca gccgcatgac caataatgtc 3006181 ataaacgtcg gcgcaaacgg cgccccgatg gcagaaaccg caacaagaat aagcccgaat 3006241 aaaaacaagc gtttccgccc aatcaaatca ccgagctttc ccgttacggg ctgcgctacg 3006301 gcactcgcca agtaaaacga ggaaatcagc caggaaaccg ttgtaaacga gaggtgaaac 3006361 tcatgctgga tgctatggag cgcaagagag atcatagacg agttcagcgg attcagcatt 3006421 gttcccgaag ccacagctgt taaaaaaaca gctcggcttt ttttcgataa catcatttca 3006481 cttgttccag aaactcttcc gttgtccgcg atttaccgat tctcgggaaa ataaagcgca 3006541 gtgtggcttc atgctcttca tcgctaaatg tggacatggc atctgtaata aaaatctgct 3006601 gatagccaag ctgaaatgcc tcccgtgctg tgctttccac cccgatattc gttgcgatgc 3006661 cgcacaatac aatcgtatca atgccgcgac gtctcagctg caagtctaaa tctgtgccaa 3006721 aaaaagcacc ccattgccgt tttgtcacag tataatcgcc atcctgcaca ccgatttccg 3006781 gaacaaattc ggcccagtcc gccggcattt cccctgaacc tccctgcgca ggctcatccg 3006841 tttgcggctt cagggcgtcc gctccatcat gaaaggctac atttacaaag ctgatgaacc 3006901 cgttatgttt ccgaaattca tctacgagct ttttcgcgtt cgggacaacc tggccgcttt 3006961 gatcaatcgg cacaattccc ttttgtaaat caatgataac caatgctgtt ttttgaaaat 3007021 caatgttgag tgtattcatc atacgtctcc tcctgatact gttagtgttt ctcacattgc 3007081 atattttact cttcacactg cctaagttct tttatgatgc ttgtgaaatt ctcagaagga 3007141 gcgttttctc atgatttttc ttttatgtag tagtaacagg ttgtgcatac gaacaaaccg 3007201 gcaagcactg taatcataaa gggcgtcatc gcttcatcac ctgcctgctg tctatcggtt 3007261 cctgcctgaa aatgcccatg aatttgcggc ggtccatcca aagcaggata agacacataa 3007321 ccattaatat cgtgctaaga tcctgcacgc caatatcaaa acaatagtta atcaagacga 3007381 tgttcacaat aatgggcata aaaataaccg cccctaatgc agccgttcgc ggaatcagta 3007441 ataaaacagc tgccaggatt tcaccaaaac ctataaacag ttcatagaca tgagaataac 3007501 cgaaaaatgt ccacgcgatc gtaaacccct tcccggcagc cgcctcgatt tcaggcgtca 3007561 cctcgccaaa ctggccaatt accactttcg ccagaccgta cacgaaaaaa ttaaaggcta 3007621 aaaacaatcg gaacgtcgcg ggaatcgact tgcgtaccgc tttcctcagc ctgccgcctt 3007681 tattcatcat acatccccct cagtgtatta tttgatgtag tacacttaat acagtataga 3007741 gtattctaat taatgtcaat tcccttttca gctcatatga atagtttctt ttatagatac 3007801 aaagtcttat atcgcaaaaa atgccattct ccttcctttc catccctcga taacatttct 3007861 caaaaaccat gtcaggaaat cttacatgaa aatgttttat cattcttttt tctctataat 3007921 gaagaaatat aataattgct ttttattctg aaagatacgg aggaatgaga catgcaaatg 3007981 ggcgatacag tttttatgtt cttttgcgct ttactcgtgt ggctgatgac cccgggatta 3008041 gcgttatttt atggaggaat ggtaaagagc aaaaatgtgc tgagcactgc catgcacagt 3008101 ttctcttcca ttgccatcgt ttccatcgtt tgggtgctgt tcggatatac acttgccttc 3008161 gcaccaggca attcaatcat cggcgggctg gagtgggcag gcctcaaagg ggtcggattt 3008221 gatccgggag attacagcga taccatcccc cactcgttat ttatgatgtt ccaaatgacg 3008281 ttcgccgttc tgactacagc gattatttcc ggggctttcg cagagcggat gcgattcggc 3008341 gcttttcttt tattctcggt tttatgggcc tctttggttt acacacccgt agcgcactgg 3008401 gtatggggcg gcggctggat cggccagctt ggagcgctcg atttcgctgg cggcaatgtt 3008461 gttcatattt cctccggggt ggcaggactt gttcttgcca ttgtgctcgg caaacggaaa 3008521 gacggtacag cgtcttctcc gcataacctc atttacacct tcttaggagg agctttgatt 3008581 tggttcggct ggttcggctt taacgtcggc agcgcattga ccttagatgg tgtggccatg 3008641 tacgcgttca tcaacacaaa caccgcggct gcagccggga tcgccggctg gatcttagta 3008701 gaatggatca ttaacaaaaa accgacaatg ctcggagcgg tatctggggc aatcgccggg 3008761 cttgtcgcca ttacgccggc tgccggattt gtcacaccgt tcgcttccat tattatcggc 3008821 atcatcggcg gagctgtttg tttctgggga gtattctcgc ttaaaaagaa attcggatac 3008881 gacgacgcgc ttgacgcctt tggcctgcac gggatcggcg gcacatgggg cggaatcgca 3008941 acaggattat tcgcaacaac ctctgttaac tcagcgggcg cagatgggtt attttacggt 3009001 gatgcaagct taatctggaa acaaatcgtc gccatcgccg ccacttatgt ttttgtattt 3009061 attgtcactt tcgttattat taaaattgta agcctcttcc ttccccttcg cgcaactgaa 3009121 gaagaagagt cacttgggct tgacttaacg atgcacgggg aaaaagcata tcaagattct 3009181 atgtgaggag tgacgctatg agcggtcaaa tgttcaaggt agaaattgta acgcgtccgg 3009241 caaattttga aaagctgaag caggaactcg gaaaaatcgg agtgacctct ctgactttct 3009301 ccaatgtaca cggctgcggc cttcaaaaag cacatacgga gctctatcga ggggtaaaaa 3009361 tagaaagcaa tgtatacgag cgtttaaaaa tagaaattgt ggtcagcaag gttcctgttg 3009421 atcaagtgac agagaccgct aaaagggtgc tgaaaacggg atcaccaggt gacggtaaaa 3009481 tatttgtcta tgaaatcagc aatacgatca acatccgcac aggcgaagaa ggacctgaag 3009541 cactttaata tcggtacgag attcggacac tccggatctc tttttttgtg cacagaatcc 3009601 ccccagaaac cgcgattcct cttcgaattc tcttcaagcg ccgttatttc agacaatctc 3009661 tatttttatt tgaaactttt catgagtaag attagtctac taaatataaa aatgtaaaag 3009721 gtgattattt gaactacgaa atttttaaag caatccatgg actatctcat cacaattcag 3009781 ttctcgattc cattatggtc ttcatcacgg aatatgccat tgtcgcctat gcccttatcc 3009841 tattggcaat ctggctgttt gggaacacac aaagcagaaa acatgtgcta tacgcaggca 3009901 tcacaggaat tgcaggcctt gtgatcaact atttgattac gcttgtttat ttcgaaccgc 3009961 gcccgttcgt tgcgcataca gtgcatacac tgattccgca tgctgcggat gcttcatttc 3010021 caagtgacca tacgacaggt gcattagcga tttctattgc gatgcttttc agaaaccgca 3010081 aaatcggctg gccgcttgtc atttttgggc ttttgacagg cttttcgaga atttgggtgg 3010141 gacatcacta tccggtagat gtattgggca gcctcgttgt cgccatcatt atcgggttcc 3010201 ttttctttag attttcagat ctgcttcgcc cgttcgtcga tttggtcgtg aggatctacg 3010261 aagccattat caataaactg acgaaaaaac caaccgatca aaatttctaa gaaagacaaa 3010321 agccggcgtc tgaaatcaag acagccggct ttaatatttc tcatacatct cttgttttct 3010381 tcgcttcgcc aacacatata aaccataaaa caacccaatt ccaacagcat cgatgagcac 3010441 atcccggata caaccattcc tgctgaagaa gagctgaaga acttctgtga aaaaagcaaa 3010501 cgcaaatgag ccggctgcag ctgatcttat gctgccccgc tgtttccaca gcaaatatgt 3010561 cagcacaaag aaggaaaacg cgtgtccgat tttttgaata aacgcttcag gtacagtaag 3010621 ctcagtaaaa tccataacta aaaattgaga cagatcaggg tgcggctgaa aatgaaaagc 3010681 caccgtttgc gatacgacca tgccgctgaa gctttccgta cagacagaaa gcaggataaa 3010741 aaagatccag cctgcgagca ataggcggtt catgacataa cctcctttat aacgtacgtg 3010801 cctacatgta actacataga cggtaaaaca aagcaaaaag taacagaaaa aaacgcccat 3010861 cacaaggata gacgttttct tcattaagac tgttcagtgt cttctgttgt gctgctttct 3010921 ttagaaccag atttgtcagt tgaatcatcc tttttctcac cggatttttc ttctgttcct 3010981 ttttcagttg atccgtcctt tttctcggaa gattgctgaa tggattcttc tgtttcttgg 3011041 gtggcagctt tttcaataga agaaactggt ttgtccataa agtttaacgg attcattgca 3011101 accccatctt tacggatttc aaagtgcacg tggtttccgc tgtcttcact gtaaaggttc 3011161 ttgccagatt ttccgatcac ttgattttgt tttactttgt caccttgctc tacgcttact 3011221 tcggaaagag attgatacac agtcgataaa ccgtcggcat gttctacttc cacaacatat 3011281 cccagcactg gatctttttc agctttaaca accgtaccgc tcagagaagc agagacatcg 3011341 aaatcttttc cgtctttctc agctaagtca attcctttgc ttaggctgta cgtgttatta 3011401 taggtaacga gtgctgcttc tttctcttct tttgcggcat cggtttcata gaactttttc 3011461 acaacagaaa cgttttcaga atcaacaacc ggcattgcga cattttccat tgactttcct 3011521 acttcaactg catcgtcgtt gttgtcatat gcggagtttc cgccgttatc agccaactga 3011581 tcctttacct catcatttga tactgattga taccaaagga cagctgttaa aatgacggcc 3011641 gcactgacta agtaaattgc agggaacacc cagcgtttac gaaaaaactg ctgaagtttt 3011701 ttgacttgag aagttttctt ttcttcctct ctcattgttt catcacctca gcaacattct 3011761 gaacactttt ctgaaaatat atacaaccta tccaaaaaaa cttttttaga tgtagtttgc 3011821 acagactgaa cgaaaatatg tatttttttg agaggagtgc caaaaacgta tgaacatgac 3011881 attgcgtctt gctgaacata gagacttgga ggctgttgtg gcgatttata attcaacgat 3011941 tgcttctcga atggtaacag ccgataccga accggtaact cctgaagacc ggatggaatg 3012001 gttttcggga catacagagt cacgtccgct ctatgtggcc gaggatgaaa acggaaacgt 3012061 cgctgcctgg atcagctttg aaacatttta tggaaggcca gcctataata aaacagcgga 3012121 agtcagcata tacattgacg aagcatgccg cggcaaaggt gttggatcat atttgcttca 3012181 agaagcgctc cgcattgccc cgaatcttgg catccgctca cttatggcct tcattttcgg 3012241 gcataataaa ccaagcctga agctgtttga aaagcacggg tttgcagaat ggggactatt 3012301 ccccggcatc gccgaaatgg acgggaaaag atacgattta aaaattttag ggagagagct 3012361 ttcatgatta gtctggataa agatgaaaac gaaattgaac atcataatga agaaaatagc 3012421 cttgttgaac aggagactgc acctgttgga caggagagcc gccagctgag cgcctccgct 3012481 gtcaagtcgc tatccgacat tgccaagtgg ggcaaaattt ctggcatctt gttaatcatt 3012541 atgggatcgc ttgtcactct gtctgttttg atgacagtga ttggcgccat cccgggcgta 3012601 ctgctcatta tttcaggcgt atttttgatg cgctcagcaa aagcagccgc ggaagccgaa 3012661 ggaaatctaa ccggcagcgc tggcgaaagc atgcttgaaa attacgggac atttataaaa 3012721 atgcagctgt tttatgcagc atccagtatc gttactgtcc tgatcgggat cattgtagcc 3012781 attttcgtgc tggtggtaat cggcattgct gcttttgaga acacgccttc gtatgatgat 3012841 ccggattctt attattatga ggatgatccg gtgtttgaat aatgatgaga caggacaggg 3012901 catgagttcc atataaacgg aaccatgcct attttatttg actattcaaa gcaggccggc 3012961 gtaaacacca aatcctgaag caagcataca atagacatct ctagtagagg aaatcaacaa 3013021 agcaacgctg ttacccagaa atgaatatca aaaaaacgga tgaagtcgga atcaatccga 3013081 aaccgcactt tttatttcgg gtgtctgcat gcaaaaaaac acacccggat cgtctggaaa 3013141 atctcaacaa tccgggtgca gatcttcttt aatacatttt tttgcgtctg tcttcctcag 3013201 tcaaaaattc aacaaaactc cgcatcgcaa aaggctcttc ctttatttgt cgtgcgtagg 3013261 agcttttccg ctcttctgaa aggatttcgc tctttttgat cctgttcagc atatagatgt 3013321 gaaccgtttt ttggatttgt ttatgctgat agcctgcctc tttaaaaaat gcgagcccga 3013381 gcgccgccaa aagggcgaat atgcctgcgc tgatcaggga ctccctgtca gctgaagcat 3013441 gaaatagaaa agcagctaaa ttaaagagag agaatgcagc aagcggaata gcaagaaaac 3013501 ggtaaatgac ggtttttttc atgaaaggct gtacggcctt ttgaattttt tgcatttctg 3013561 ttttgatgaa ccccggcatt tgttcgactc tgtaaaagtt catataatcc tcccccttta 3013621 tttgatgttt caagcttcac gaacgttatc atatgtgttt attttaacgc aggtgcaagc 3013681 tggttttaaa gaaatctgcc cgtatttttc acgaagaatc tggatcgccg ctctttattc 3013741 ttttaaaatg tgagtgttat aatttgtaat gggaatcaga tcactgttat tcatggaata 3013801 ctaatggcaa tcttcttgat aaatatgaat gagcggggtt acaaagtgag tatttcttcc 3013861 atccttttat cacttttttt cattttaaat attcttttgg ccatcattgt catcttcaaa 3013921 gaacggcgcg atgccagtgc atcttgggcg tggctgcttg ttcttttctt tattcccgtt 3013981 ttaggcttta ttttatactt attattcggc cataatctca gacgcaagca tttgtttcaa 3014041 tgggaagacc ggaaaaagat tggaattgaa aggctgctga agcatcagct tgaagattta 3014101 gaaaccaagc aatttcagtt taacaaccgg gcaacctttg ataacaaaga tttaatttat 3014161 atgctgatta tgaataacca tgctgtgttt acagaggata attcagttga cgtcattaca 3014221 gatggacggg ataaatttca gcggctgctg agtgacattt caaaggctaa ggatcatatc 3014281 catttacagt attatattta taaaggcgat gaattaggca aaaaattgcg ggacgctctc 3014341 atccaaaagg cgaaagaagg tgttcaggtc agagtgcttt atgatgaact cgggtccaga 3014401 acgctgagaa aaaagttttt taaagagctt cgcgaggctg gcgggcatgt ggaggtcttt 3014461 ttcccgtcaa agctcaggcc gattaacctg cggctgaatt accggaacca tcgaaagctt 3014521 gtgatcatag acggtatgac cggttatgtc ggaggcttta acgtcggaga tgagtatcta 3014581 gggcttaatc cgaaattcgg ttattggcgg gatacgcata tccggctgca aggaacggcc 3014641 gtgcacgcca tccaaacacg attcatcctt gactggaacc aagcttctca tcaccatacg 3014701 ctgacatata ttccaaatca ctttcctgat tacggcccaa aaggcaacgt cgggatgcag 3014761 attgtcacaa gcggccctga ttcggaatgg gaacaaatta aaaatggcta catcaaaatg 3014821 atttcgaacg ccaagcgttc cattttgata caaacacctt attttatccc agatgcaagc 3014881 ctgctggatg ctttaaggat cgcttgcctt tcgggcattg acgttaacat tatgattccg 3014941 aacaagcccg atcacgcctt tgtatactgg gcgacacttt cgtatatcgg cgatctgctg 3015001 aaagccggag ccactgtcta tatttacgat aacggcttta ttcacgcgaa aaccatcgtg 3015061 gtggatgacg aaatcgcttc agtcggcaca gcgaacattg atgtccgaag cttcaggctg 3015121 aattttgagg ttaatgcatt tatttacgat atcaccattg ctaaaaaact ggtttcaact 3015181 tttaaagaag atttgctagt atccagaaaa ttcacctatg aggagtatct gcagcgcccg 3015241 ttgtggattc gaataaaaga atccgtctcg cggctgttgt cgccgatctt ataagatgcg 3015301 taaacccccg gcctttacgg ccgggggttt tcctgatggt cacagtaaat gatgattgcc 3015361 tcccgcaaaa aagcggcaag accttctcca tattgattga ttgaatcggt aaatcgctcg 3015421 tcagtgatat acacttcccc gagtcctctg aaaatgtcga gtgtgcaatc gtaatgatat 3015481 tggcaaatat gatcgcgaaa tgcccccaca gcggcctgaa tctctgcatc atcgggccca 3015541 tgcttcattc gcgccgcaat tcgtctgtaa atcgaatcaa attcagccat gatcgtgcgc 3015601 caatcatctg ccgagtatgc agatgtcctt ttctctgttt cttctgcgat ttcctttcca 3015661 tacagctttc tgacttcatc agcgtatgtc tgctggtgct cttcaatgtc tttcatgctt 3015721 aatccggcaa ataaatccct cttattcatc gtttcccctc catcaacgga caaaagcgtc 3015781 ctgtcaattg tttgaatcat ctcatccatt ctttgttttt tcttcatcaa tatctccttt 3015841 tgcgactgaa gtgccgcttt ccggtcaaaa ttcggatgat ccagcatctc tttaatctca 3015901 tccagacgaa acccgatttc cttgaaaaat aaaatctgtt gcagtctttc caggtctgcg 3015961 tcactgtaca aacgataccc agcatcagta agcgctgaag gattcagaag ctcaatattg 3016021 tcatagtgat gaagcgtccg aatgctaacg cctgatatct ccgccacttg tttaacttga 3016081 tatttcatac ataacacctc ctctttttta tcgtaaacaa tcacgcaacg ttagggtcaa 3016141 tccccaaaat gttattttct atatacaaaa cttctcacaa atagtgtata aaagaaaagt 3016201 gagtattttt ttgtaaaggg gagccagtat acatgaatcc tgaaacaatg aacaaaaccc 3016261 tcatcagcat ttcgaaatgg ggaaaagcta caggcatttt atttattatt atgggcgcaa 3016321 ttaccgcgct ttcaggcgcg ttcttttttc taatcggtgc cgtgccaggc gtactgcaaa 3016381 ttatttccgg tatctttttg atgaggtcag ctagggaagc aggccaaatg gctgaacaca 3016441 atagcggaca gtctgaagac ttaatgctgg agaattacgc gaaattcgta aagatgcaag 3016501 ggatttattt gatcgtaagc attgctgtat ccattcttgc gattatcgcc ttcttcatct 3016561 ttttaatgct tgggattgct gacggccttt tcagcgatac gtacagcact tattaatgag 3016621 aaaaacccgg agctggctcc gggtttttta ttattccgct tcgcttacca ctgtgaagcg 3016681 ttcatttttg tgttcgggat gttcaagctc gtccaacacg gcaatggcat aatctgcata 3016741 gctgatatag ctgtctcctt ttgcatttac gatgacattg tcttttcctt tttggtaaga 3016801 gccagtccgt tttcctgctg gatcaaaaaa tgccgcagga ctgaggaacg tccaggaaat 3016861 ggagtctgtc tgctgcaaat ctttcaggtt ctcgccttga tttgatgcag ttggcaaata 3016921 ttctttcgga aattccggcg tatccattaa acgggttgtt ttggcttcat caacaaacag 3016981 gcttcccgct ccgccaacaa caagcaatct tgtgtgcttc gcgtccttta aaatgctgat 3017041 gagtgctctt cctgcttcaa catgaagatg ttcttggccg ggtgctgctc caaaagcgtt 3017101 tacgaccgcg tcgaaaggct tgatgtcttc cgcagtcagt tcaaacacat ctttttccaa 3017161 aatcgctacg tcttgctcct gcacttttga agcgtttctg acgatggctg tcacttcatg 3017221 gcctcttttt ttcgcttctt tcaaaatctc gtttcccgct ttcccgcttg cgcctataat 3017281 accaattttc atttttcatt tcctccttat ttgtaacaat tttagttaca tgttagcggt 3017341 gagaagtcat cccttttgat taaaagagat gattcataac atcttttaat gacttgcttg 3017401 ccagttcatt ttccatcgct ctttgcacac tttcaaacgt ttcatccaga gcgttctgaa 3017461 tttttttccc taccggacat ttcggattcg ggttttcatg aaccgcaaag agttcttctt 3017521 gcttttggac agcccggtac acttctaaaa gagaaatatc agcaggatct tttttgaggc 3017581 ttgcacccgg caccccggcg cgtgatgtga gaatatcagc ttttttcagc aggctgatca 3017641 ttcttcgcac aactaccgga ttcgtgttga cactgtctgc aatgatttct gaagatgttt 3017701 tttcatccat cgagatgagg gataaaatat gaatggcaac agcaagacgg ctgttaatca 3017761 tgttttttca ccaccgttgt aactataata gttacatttg attcgtttgt caacatctaa 3017821 tatacactaa atacatgggt tttgtgcacc gtttttagtc aatagaacgg ccggatgcac 3017881 tccggccgcg tcttatcaaa ataagaaata tctttgtcca agtgggacat aatcgacagg 3017941 ctggcaagac aattcctccc cgtcagcaaa gacctgatag gtttttggat caatctcaat 3018001 cttcggcaaa gccgaattca gcttcatatc cagcttgctc agctttctga tatttttgac 3018061 tggagaaatc cttttttcca gccctaagct ttccgccaca ccacgctcta tgcttgcctg 3018121 agacataaat gtaatcgagg ttgagcggtt ggcttttccg taagacgcat acatttggcg 3018181 catgaaaacc ggttcaggag tcgggatgga cgcgttcgga tctcccattt gcgcacgtgc 3018241 aatcatgccg ccctttaaga ccagttccgg tttcacgccg aaaaataccg ggtcccacag 3018301 aacgagatca gcaagcttcc ctttttccac cgagccgacc tcatggctga gcccgtgcgt 3018361 aattgccgga ttaatcgtgt atttggcaat gtaccgtttt gcgcgcacat tgtcattccc 3018421 gttttcaccg gcaagagcgc cgcgctgttt tttcatttta tcggctacct gccatgttcg 3018481 gatgatcact tcaccgaccc gccccatcgc ttgggaatcc gatgatgtca tgctgatcgc 3018541 acctatatca tggagaatat cctccgcggc aatcgtcgcc gccctgattc tggaatggct 3018601 gaatgccaca tcttcaggca ctttcgcatc taaatggtgg cagaccatca tcatgtcaag 3018661 atgctcatcc atcgtattaa cggtataagg aatggttggc gttgtagatg acggcagaat 3018721 gttcgcgtaa gaggcgagct tcataatatc cggagcgtga ccgccgcctg ccccttcaat 3018781 gtgataagta tgaataaccc ggtccccgat cgcgtcgagc gtgttttcca aaaagcccgc 3018841 ttcgttaatc gtatcggtat ggatggcaac ttgaatatca gcctcgtcca cgacttccat 3018901 acacgtttta atggcgcttg gcgtcgttcc ccagtcttca tggagcttaa gaccgatggc 3018961 gcctgcttcc acctgctcga tcagcggcgc tttatcggat gcattccctt ttcctaagaa 3019021 gccgacattg atcggaaact cctcggccgc ttccagcatc ctcgccatat accacgcccc 3019081 ggacgtacat gttgtcgctt tgcttcctgt agcgggtcct gttccgcctc ccaaaagggt 3019141 cgtcacacct gaagaaagcg caacttccat ctgctgagga caaataaaat gaatgtgcgt 3019201 gtccactccc ccggctgtta aaattttgcc ttcaccggaa atcacctctg tccccgctcc 3019261 gatgaccatg tgcggatcga ctccatccat gatatcagga tttccgcttt ttccgacacc 3019321 gacaatccgg ccgtctttca caccgacatc cgctttgaca atgcctgtgt aatccaatag 3019381 cacgacgttg gtgataacca aatccaaagc gccgtccttc cctgtgattc tgccgttttg 3019441 gcccatgccg tctcggatag tttttccgcc gccaaagatc atttcttcac cgtatactgt 3019501 gaaatccttt tcgacttcga tccataaatc cgtgtcgccc aatctgattt tatcgcccgt 3019561 tgtcgggcca aacagttccg catattcctc ccgtgacatt ttcatcggat tacaccctcc 3019621 atccagccgg cttgttttaa gttggccaac gttttttctt tgccgcgttc atcgataaac 3019681 gtgtcggcca ttccgttcag ccctctaatt gtcttgcgtc ctctgatttc cactagtgag 3019741 accgttttct gctctcccgg ctcaaaacgg accgacgtgc ctgatggaac atcaagacgc 3019801 atgccgatcg ccagctcacg gtcaaataat aaagccccgt tggcctccgc aaaatgaaaa 3019861 tgcgaaccga cttgaatgga gcgtgatccg gtgtttttta ccgttacctc ccgtatctca 3019921 cggccttcat taatcgtaat ggttccctca gcaatttgaa atgctcccgg cttcatgact 3019981 tcacctccgc agaaattggc tgatgtaccg taacaagctt tacaccatcc ggaaatgtgg 3020041 cctccacctg aatgctgtcc agcatctcag gcacaccctc catcacatct ttttccgtta 3020101 atacatggcg gccggcttcc atcagctctg ctactccctt cccatcacgt gcgccttcca 3020161 taataaagca ggtgatataa gcagcagcct caggatagtt cagcagaacg ccccgcgcct 3020221 ttcgctgttt ggctaattcc cccgctgcaa aaatgagcaa tttctcttgt tcaactggtg 3020281 tcagtttcat ctgtagtcct ccttcttttg tcatataaag cagatgcggc tactacgaat 3020341 ttgcggaaca gtcaggcggg acatcacctc cctttcttcg agaatggggg tcatacggta 3020401 agatgccttt caaagcggca tgccgtttct tcatcagcct tgccatggtc aacaaccgtt 3020461 cccctgtcga tcacggaaag atcagattaa cgcgttttcc agactgcgct cgactaagat 3020521 aacaaatgtc tttttttctg gaaatttcta taataacttg tctgactagt tcgacaatta 3020581 aaatctgaat tccttccaat tgtttattaa gtaaaatatt tttcagattt accatcagcg 3020641 ctctggtgat tgcaagctgc tgctgttgac cgccttttcg ttttgaacaa acgtttgatt 3020701 aaaacaaata gccccctctg tttagccgga gtcggcctaa tacagcgaca atctgccccg 3020761 ggcgaagcta aggctgtgca aaaccatcga ttgatcataa ccagacgtta cattcctgat 3020821 ggcagcccgt tgttttgctc cgcaaccgga agcatggcat ggaggccagt ctgaggcgcc 3020881 gacctccacg ataccgagaa cccgactatt gccattaact ccgcatcatg gacggtcact 3020941 tcgctgatcg ccaccgttcc tcttaatgag tgaagaattc cggccttcac tgaatccccg 3021001 cttgtgtcga tatcaactgt tttctcgcac tcccgtggct tccgacactt tcttcggtgc 3021061 agtacattcc gtcatcaaaa cccctttgtt tgatttcttc aaatgatgtt ataaaagttt 3021121 acaacttatg tcatcattat atagaagagg cctattaatt caaagaatat ttaaaaaatt 3021181 tagttacctt gaccaaatca gcttcttttt ttgttatatt tattcacatc agaaaaagcg 3021241 aaaaaaaaag acaagaaaca tttcgtttcc tgcctcttcc gtacgattaa tctttatctg 3021301 aaaatttatc cttggctttc ccgatatcct tttggatttc gccttttgcc ttatcttttt 3021361 tgccttcagc ctgcatgtcc gttctgtcag ccatatctcc gactttatcc ttcacttctc 3021421 ctttggcttt attgaagccg cccttcattt tgtcttttac actatcgtta cccatgttaa 3021481 ttctcccctc tcaattatgt gtgtacttgt taacttcccg atctgagagg caataaacat 3021541 tctaatgtta tttatcgatt tcgtagcgct ctccgtaacg gagcaccttg tatatcgcca 3021601 gcccgtctga tgactttttc tccgaatatc ggaccggcag cagggcaaaa aacacataat 3021661 acgtagaaaa atagacaaac tgatagaaaa acacattcgg ctttaataca ctgtgtataa 3021721 tcagcagatt gattgcaaaa atcgtgatga ggttaaacaa gcagccccct gcatacacga 3021781 gtgcatttga gaatcgattg tcaattttca actccccgta ccggcaaaaa gaatcgataa 3021841 aataaatcgt tctgaaccgt atgggtccaa ttttaagcag cgtttttccc atgcctatat 3021901 ccaacgatcc ctttccgcca aaaataaaag ccataaagct gtgccctgaa acatgtataa 3021961 tctgtacaag cggcagaaca atgaggaaag accacagaaa cttcaccata tcattaaaac 3022021 caaacattga attccccctc acatgcatat ctgcatccca aaacggcttt tgttcaaaaa 3022081 acagtgctgt agcgattttt cctgttctcc ccggaaataa acgttccgat gctccccttt 3022141 ttttgcataa aaaaaaacca tctgccagca gatggttttg tctcatactt catataaaca 3022201 atcgttcctt tgaatcatct ctctcatgct gaccgctttt tcataaaaat acaccgcttc 3022261 tttatattgt tcgcgatgac tgaaataaga ggcagcatct aaagcaaatt cttcaatata 3022321 tacatacagg cccttttctt ccatataatc aaatacttct tgaatcatat tcaaattgac 3022381 agattccaca tataatgcct gcagaaattt atattttgcc agactgaaga agtcgtttcg 3022441 tttttgggca atggcaatcc ctttttcata gtaccgtatc gcggcttcgc tatcttgttt 3022501 tttgaaaaga acgcgagtca ggctgaagag cgcttttgga agctgttcca gctgataatc 3022561 ctcgaagaca ggaagcgctt tttcaaagta ttcggcggcc tgatccagct cccccttgtc 3022621 atcatagcaa ttaccaatat tataaagggc tgatccgatc aaacggggct gtccttccaa 3022681 taaagcaagg cgatacgcgt catctaaatg ttcaagcgct ttttcataat ttctgtagtc 3022741 aatgtagttt cctgatatga cgaaatggca ttgaattctt ctgactctgt aaaaatcgtg 3022801 agccttatac gtctccagcg cctgtacggc atggttcatg gaaaagtgcg tctgcttcat 3022861 aatataaaag acttccgcca ctttaaaatg aaattccgct ctttcaattt catcttctac 3022921 aaacgcaagc atcttctcag ctttccgata aaaggatata gccgagatgt aattgttctg 3022981 ttcaaattcg tacattcctc taaacaagtg aaaataatac tcagataatc cggagatgct 3023041 gtcctgattg ctttccagcg ttttgatcaa ttcacgatat tgaagctgag attcctcgtg 3023101 caggtcaggc tttacataat ccagcataat ttggtgccgg tagctgatca gctgataata 3023161 caggagaagc agctgatcct cttccatctg ttcgatatct agatcaattt cttctttcag 3023221 ttttacggca tcagccactt gaaatgctaa aatgtgctta taccacttat tgattttcac 3023281 tcctacttga gatgacggga tctcgtacgc ggccatgccc ctccaaccct ttctattttc 3023341 taattggtta tattttatca taatgtatgg ctttggaatt aaattttctt acaatgattc 3023401 cttctttatg cctatcctta tatatttcgg tttttctacg tattttttgc actcggattc 3023461 taataaaaaa gcttaccgga cagtgccgat aagcttttga cttcaaatta accgccaata 3023521 taagacattt ccactttctt tttgccagat gcttttgata gcgtacgatc gactgaatac 3023581 tgatcgatcc gatttttcca tactgtcccg atcatttctg atagttcgtc atcacttaat 3023641 tcctggcgaa ccggagctct gaggtcaaat ccgcttgaag cgaataagca ggtaaacagc 3023701 tctcctctcg cagaaagacg ggctctgttg caagatccgc agaatgcatc agatacagat 3023761 gatatgacgc caatttctcc ggagccgtcc aagtagcgga atctggaagc cacttcgcct 3023821 atataattag gcgctatcgg ctcaaccggc atgtgtttat tgatcaaatc tatgatttcc 3023881 gcctttgtca tgacgtcttt cttttcccat tggttggtgt tgcctacgtc cataaattca 3023941 atgaatctca ggatatgccc tttttcttta aaataacggg ccataggcag tatatctttt 3024001 tcattgacgc ccttttgaac gaccatattg attttaacac cgagccccgc ttgcttcgcc 3024061 gcttcaatgc cttccagcac cttgctgaca gaaacaccgc gcccgtttat cttcttaaaa 3024121 cgctcgtctt ctaaagaatc aaggctgatc gtaacccttt tcagcccagc ctccttgagc 3024181 ctcttagcat aaacaggcag cagtgatccg tttgtcgtca tcgcgatgtc acgaataccc 3024241 ggtatgcggg ccagtttttt gattaattcc ggcatatcct ttctcatgag gggctctccg 3024301 ccggtcaagc ggattttttc aacgccaaat cttgtgacaa acaatgtcgc aagccgttcc 3024361 agctcctcaa atgaaagcag ctcctctttc tttaaaaaag gataatccgg gccgaataat 3024421 tcggcgggca tacagtacgt gcatcggaag ttgcagcggt ctgtaacaga aatgcgaagg 3024481 tctctcagcg gtctgtttct tttatccaac atctgacgcg actctgtaat catagctaca 3024541 gccccttcct actccctgat tctctcaggg tgtgtatata cattaaatga tccgtttctg 3024601 acaaatccaa tcgctgtgat attcaattct tcagccattt gaatcgcaag ctccgtcggg 3024661 gccgatttgg aaatgacaat cgacacgccg attttggccg cttttaacag gacctctgat 3024721 gagattctgc cgctgaacac aatcagtttg tcgcgtacgg acatcccgtt tagaaggcag 3024781 tgtccgtata gtttatcaag tgcgttgtgc cgaccgatat ctgtgcgcat caacagaagc 3024841 ttctctgtgt cgcaaagcgc cgcattatgg acgcctcccg tatcctgaaa cgtcccgctc 3024901 ccttgctgca tgtctttcat aagcgccaga catgcctcag gcgatatctt gatttggctg 3024961 acagccgtct tggctgtttt gacatcctgc tgaaaataaa aatgacggcc ctttccgcag 3025021 catgagccga tcacccgttt cgtataatcc ttttgatcca atgtctcagg gtgaacgagg 3025081 tcgacatata caaaaccgag actttcatct attgtaaacc ttttaatttc tttttgaaat 3025141 cgtataacac cctctgatgc gagaaatccg atgacaagct cttcgatatg ctcaggcgta 3025201 caaacgagcg tcacaaattc actgccattc agtatcactg tcaaagggaa ttccgtcacc 3025261 atccggtctt ctactttgct tatttcccct tgttcatagc gccatacatc cctgaccgca 3025321 gttactttat cgttcaatgt ctcttcccct ccgcaatgtt cctgccttta tattttttca 3025381 cactcctcgg attttgtcga attctgagac acaaaaagag ccctctatat aaagggcttt 3025441 tacaggatgt gatgacggcg gtgtttaggc aggacgccta agcatttagc cgccgttcct 3025501 tttataacac gtgagcacca atgtgcattg acaacgaacg cggggtttgt cgacacgctg 3025561 agacacctct gtataaagga ctctatgttt gattatgctg attctttttc agaaccgtaa 3025621 acagcacaat agctgcgatc aaggtgagaa tgctgacaaa aaagaaggct gccagtttta 3025681 gaagaacacc aagcaatata aatgcaacgg tggctataag aaaaatcatt ccgaataatt 3025741 tcatatgttc aacccctttt tagggtatca ttcccgccca aactgttttt aaaccaataa 3025801 aaaaggcgcc tgggggagcg cctgatcttt aggttcctta ctcagtaaat ttttgtgctt 3025861 ctttttccca agcctgttcg aactcatccg cactgttcgc tgaaatatat tctccgccgc 3025921 cagcgacagc tgcttgtttc atctcttcat tacccttgac atcaaagttg aagccaatga 3025981 tgtttacaat cgtatccaca tttgatgcac ggagcttttc gatttccgcc gcagggtctc 3026041 cgccgcacgt ttcttcaccg tcagtgatta aatacaccac gtttttcccg tctgcgtcaa 3026101 atgcttcaaa ttcttttctt gtgtctgcaa gtgctttggc aatcggtgtc catccagtcg 3026161 gcttgagctc actcaatgaa ttgtcaaaca gagacccttc atatggatga aggccgtaaa 3026221 tggtttccgt cgtactgcac gaaagggctt taccggacag tttattgttc cctgcatgcc 3026281 cgaaaacgcg aagcataaga tttgtatcct ttggaagaag ttcggcaaaa gattttactg 3026341 attttttggc aatgtctatt ttgcgctctc ctcctgtttt ttgaaccatg cttccgcttc 3026401 cgtcaaacaa aacagctaca tttgtatcag cctgtttctc agcggcaaaa gacggggagg 3026461 caatggaaac agtcaacaat ccaatgatac cggcagccag caattttttc atatgattac 3026521 ttcctttctt tttcatattt tccaactata tgttggattc ttctttatgc tagaatacga 3026581 aaatgcaaaa agatatagga catgctgcct tttgtgctgc tttcacgatc tgtccaaaat 3026641 cgcttgaaat gccgttcatt tttagccatt tccgcccaga aagcataaac agcttgtgtg 3026701 atcattcatt cttttttcgc cttgattatg acagaaaaac ggaaatctgc tactatgcta 3026761 caggcagaca gctaattagt tttgaagttt ttgttacata caaaaagagg ctgaccatca 3026821 ccagcctctt ttttcttatt tagataacat tagtgattgc tgagtgaaaa ttttctcaac 3026881 atctttttgg gtataagccg ggaagtattc accgccgcct actttcgcaa ttgcgttcag 3026941 ctggcctttg tatccctctt tataatcaaa gccgatcaca ttaacagtga tattgtcttt 3027001 ttgcagttcc tttgctgttt taatcgggtt tcctccgcac gtttcctcac cgtctgtcaa 3027061 cagatacacc actttttccc cttttgcatc aagctggtca aaagaagatt tcgcctcgtt 3027121 cagcgctttg gcaattggcg tccagccagt cggcccaatt gtattgagag aattgaggaa 3027181 gctttgctcg ttaaagcttt ggaagccgta tacgttgcga atggcttcac atgactgaac 3027241 ttttccggaa tttttattgt ttccttcaga gccaaacacg ctcattttca cctgagttcc 3027301 ttctggcaat gagctcgcaa actttgaaat ttcttttttg gctgaattaa atttagatac 3027361 accatctatt cttttcgcca tacttccgct ggcatcaagc aagaccgcca cgttcgccgg 3027421 cgctttagcc tccgtttctg tcttttcagc tgcaaaagca ggtgaagtta atccaaaaag 3027481 caatcctgtc atcatgatca gtgaaaatct tttcttcatg ttcgtacccc tttaccaatt 3027541 tgtttctgcg tgcagatgtt caacgctgaa cataatctat cgtaatcaac aaaaaccgag 3027601 aaataaatag ggcgggcttc cccattgctg ttgtttactt ttgcatagaa acctatgttt 3027661 ttattagtga tttccaccta acgcccctat gaaaagagaa gattgtccgc ctttcggctt 3027721 tcgttatatg agtctgtcga agtctgtcga caaatgtgga tgactttacc acaatctcaa 3027781 agcctgaaat caggaaaaaa ggactgatcc ttaaagacgg tcagaagctc ctctaaaccg 3027841 tttcagctac tcttagataa aagatattca ggaacagaaa aagacgccca atgagcgtct 3027901 ttttctactt tttcgccata tatttattca aaaacgcatc tgcctcagaa atttgtgtgc 3027961 cttggtaata gtactttaca atgtcatcaa ccgttttgcc ttctttggcc ataaaattcg 3028021 ctccgtattg gctcatcccc acaccgtggc caaatcctct cgtcgtgact gtaattgtgt 3028081 ctccatttcg cttccattca aaatcggcgg agttgagacc caacttttca cgtatgtctc 3028141 ttcctttcag cgtcttgccg ttaatgacgg cagttgcgac ctggtggccc ggtgtctcgc 3028201 cggtaatctt ccctactgcg ctagatccat ccagcttgac gccaagcttt tgctgaaatt 3028261 ctgccgctgt aaaggttttc gttgccttat atttcggaga ctttttatcc catgggcttt 3028321 tgacgctttt taaatatggg atagcacttg tccaataagc ttctgcattc tctgtgtagc 3028381 cgttgcttgt ggagaaaaag gatgcttcaa tcggctggtt gttgtacgtt aagattttgc 3028441 cttgcgtact ggctaccgca tctgtgattt tcttcagttt tgtctcatag cttgtgcccc 3028501 actgtttttt cagctccgct ttgcttttat acacctggaa catctgtgta tcatccacca 3028561 gtgagccttt aggagcttct accgctgaat ttgacaccat cagtctgaca ataaatgttc 3028621 tggcggcaag cgcctgggct ttcagcgctt caggtttaaa ggttgccggc atttcggagg 3028681 cgacgactcc aatcacatac tcttcaagcg gaatgttttc tacggattga tttgcggttc 3028741 gatagacggg aatagaaaca ggtgatgctt tcaatgtttc tgctcctttc gatgctggtt 3028801 tcgtgctgac tgctgtcttt tctgattcta cgctggcccc cgcttcctta ttatgctgga 3028861 atggtataac caagagtgtg ggaaccaaga gaatcaatgc acatagtacg gatagtgtga 3028921 ttgcgaattg tttcatattc agctgcctcc tgctcgggat tcgactctag tctagtctat 3028981 gggcagggac aagctaatat gactctcgtt ttggacagaa actttatttg tcatttacgt 3029041 attctttttt gctattttgc gcataatgat gataatacac aaaaaataaa aaaccagtat 3029101 gccagagtga catactgatt ttcaagtaag tttatgcatt taagtcagaa acgacttctt 3029161 tattctcttg ctcagaagca gactcatcat ttacacgttc gatgtctgcg cccagagcgg 3029221 caagcttctg atggaaatca acgtaaccgc ggtctaagtg cttcaattca gtaacacgtg 3029281 tgtgaccttc agccactaac cccgcaagaa tcagcgctgc acctgcacgc aaatcagtcg 3029341 ctgcaacttc agctccctga agctgtacag gaccgttaat gatgacagaa cgtccttcaa 3029401 tcttgatatc accattcata cggcggaatt cttccgcatg cataaaacgg ttttcaaaaa 3029461 cggtttctgt aatcatgctt gtgccgcttg cacgaagcag aagcgccatc atttgtgact 3029521 gcatatcagt cgggaagccc gggtgaggca ttgttttgat gtcaatcggt ttaagctctt 3029581 tcgggccgat gacacgcaga ccttcacctt catccttaat tgttacaccc atctcttcca 3029641 tttttgcaat taaagaggtg aggtgctcag gaaccgctcc ttttactaat acgtttcctt 3029701 cagtgattgc agcagcaacc ataaatgtgc ccgcttcaat acggtcagga ataatatggt 3029761 gttttacgcc gtgaagcttt tcgactcctt caattttgat ggtgccggtg ccagctccgc 3029821 ggatttttcc gcccatgccg ttgatatagt ttgctaaatc aacgatttcg ggttcttttg 3029881 ccacgttttc cagcgttgtt gttccttcag ctagagcggc tgccataatc aggttctctg 3029941 tagctcctac acttgggaag tccagataaa tttttgcgcc ttgcagtcgg ccttttactt 3030001 cagcttcaat gaagccatta ccgactttga tttctgcgcc cattgcttca aaacctttta 3030061 aatgctgatc aatcggtctg gaaccaattg cgcatccgcc cggaagtgca actcttgcat 3030121 gacctgtacg cgcaagaagc ggccccatga caagcacaga cgcacgcatt ttacgaacat 3030181 attcaaaagg tgcttcagtt tgcaaagcgt atgaagcatt tacagtcact tcattatttt 3030241 caaaatgcac atctgctcct aaatgacgca acacttcgtt aattgtatat acatcggaga 3030301 gcgtaggtac atcacaaatt acgctttttt cttcacttgc taataaagat gcagcgataa 3030361 caggtaaaac ggcattttta gcgccttcaa ctttgactgt gccgtttaac ttctgaccgc 3030421 cgcggacgat gattttttcc aaggtattcc cctccgcgtc cctaaattct ctatattaat 3030481 attcagtcgt aacgattggt gtgccaaccg taacggtatg ttttccgccc attcctgcac 3030541 ttctaagtgc aatttgcaaa ttcattttat gtttcgaggt cataatgtac tcttcccact 3030601 catctgtaaa cgcagaaata gaaacgaaat ttggctcaac tacatgttct actgatcttg 3030661 cttgaaattc atttaataac tgatttgctt ttttttgcaa aacaatattc atattatcat 3030721 ctaagtgacc atttagacaa gtaaaaataa ctactttttc ttggaatatc ccaagtgtct 3030781 cccgttcaaa ctgttcatat gtatcattcc agctatccgg tgtctctaga ctcatttgct 3030841 catataataa atacgaagtt ggattgtgtt ttttgagggt tgtgacaagc tgcagtctaa 3030901 aagaagtacg attttttttg tcagtatatg tgccaattgc ctttatcatt ttatcttccc 3030961 gtgcaatcac ccaatcatat tgacgatact cttgttttaa acgttgcact ttttgataaa 3031021 attctttttc ggtcagtgac aagttttgtt ttgcatgcaa tgtccactta tctattgaca 3031081 catcttgacg ttccatcccc tctgccatct gtgctaacgg cgttaattca ctcgcatgaa 3031141 tggtatggaa aacagcaatg acgaagctta acatgacgga aatgataata gcgtggctta 3031201 cttgtttttt cttcatgttc atctctcccc cttatcccca gttttaccgg aggcaagagg 3031261 cgccatacgt aaaaatcttc gtcaaaactc gagctattcg cttcaacccg cttctcccaa 3031321 ccatttaata atgttcaaaa cctattaaaa tagataggga agctgctgtg aataattgag 3031381 gtaatctaaa aagaaattgg caacggccgt tccaatggcg attgtcagca aaatcatcag 3031441 gagtcttgcc tgcacgactt tgcctttttt gattaacgga tctatattga cggcttgcaa 3031501 cgcccaccaa gtcactgcta taaaaatcag gtgaacgaca atgccgattg cagcctgctg 3031561 tcccaataca ctcatctatt acactccttt ctctgcgttc ataccctttc ttattatata 3031621 agaagcacag ataaagatga tacattttat acagaacgga ataatcagcc aaatctaggg 3031681 ctaatccccg cttaaagtgc gattctttta catggtatac tttattggaa aggagctggc 3031741 aaatgtgaat cattcttttt ttcagcctga aaagcaatat ggtgaggacc tgccaatttt 3031801 tgatcaggaa tgggaagcaa ttgcattcta ttatgattat agacagtcac agattgaaga 3031861 actgaatgaa ttgtgtcagt tttttaacat ttctcttacc tatacgagag aaagccttga 3031921 agagcttgaa aacctctatt ttcaaagtat acaagaactt ttgcttgctg attggaatct 3031981 tcctattgaa gaattcgaga aaatgatcag tgtttatctt atagattgtg tgattgcccg 3032041 ccatgaagat gctgaatggg ttgtaaaacc ttatccctat aaagacggcg cttatacact 3032101 tggctttaga agacatcgca aatcgtggca tacaatgaat gcctgtgatg gtttatacct 3032161 gcgtccaaaa gaggatcgcc cgttgctgtc gctgtttgat tctcttgtgc gttcataaaa 3032221 aaatccttct cataaagaga aggatttttt cttatttccc tgctacatcc aatctgttca 3032281 aagcccgctg taacgcaagc tcagcccgac gaatgtcagt atcatctgat tgagaattca 3032341 aacgctcctg cgcccgctgg cgtgcagctt cagcgcgctc tttatcgatg ccttccgctg 3032401 tctcggcagc ctgggcaagg atggtgacat gatcaggacg gacttctaca aaaccgccgc 3032461 tgacggcaac catttcagtc tgcccgtctt ttttcagacg gacagcgccg attttaagag 3032521 gagccacggt tggaatatgg cctggcaaaa taccgagatc gccgctttcg gctctcacac 3032581 tcaccatttc gatatccgca tcgtatactg ggccgtcggg agtaacgata ttgactttaa 3032641 cggtcttcat gcttttaccc tcctaggacc agattaaact tctacaccca tttcttttgc 3032701 tttctcaaca acttcttcga tacggcctac aagacggaat gcatcttctg gaagatggtc 3032761 atatttaccg gctaagattt ctttgaagcc ttgtaccgtc tcttttacag gcacgtaaga 3032821 acctttttgt ccagtgaact gttcagccac gtggaagttc tgagaaagga agaactggat 3032881 acgacgtgcg cggtgaacga caagtttgtc ttcctcgcct aattcatcca taccgagaat 3032941 cgcaatgata tcctgaagct ctttgtaacg ctgaagcgtt gactgtactt cacgcgcaac 3033001 cgcatagtgc tcttctccaa caatttcagg agcaagggcg cgtgatgtag atgccaacgg 3033061 atcaaccgca gggtaaatac ccatttcagt taatttacgc tcaaggtttg ttgtcgcatc 3033121 caagtgagcg aacgttgtcg ccggcgccgg gtcagtgtag tcatcggcag gcacgtagat 3033181 cgcctggata gatgtaactg atccaacgtt cgtagacgtg atacgctctt ggagctgacc 3033241 catctcagtt gcaagcgtcg gctgataacc aaccgctgaa ggcatacggc caagaagggc 3033301 tgaaacctct gaacccgctt gtgtgaaacg gaaaatgtta tcgatgaaga acagtacgtc 3033361 ctgtccttgt acatcacgga agtgctcagc cattgtaagg cctgtcaaag caacacgcat 3033421 acgtgcgccc ggcggctcgt tcatttgtcc gaataccatg gctgttttgt tgattacgcc 3033481 agagtcactc atttcgtaga aaaggtcgtt cccttcacga gtacgctctc ctacgccggc 3033541 gaatacagag ataccgccgt gctcttgcgc gatgttgttg attaattcct ggattaatac 3033601 ggttttacct acaccggcac caccgaacaa tccgatttta ccgcccttaa tgtaaggagc 3033661 aagcaaatca acaactttaa tacctgtttc aagaatttca acttctgttg aaagctgatc 3033721 gaatgaaggc gcctgtctgt gaatcggatc ctttttcgca tccgcaggaa ccggctcatt 3033781 caaatcaata ttttctccga gaacgttaaa tacacgtcca agtgttacat caccaaccgg 3033841 tactgagatt ggcgctcctg tatctacagc ttccataccg cgctgaacac catctgtaga 3033901 tgccattgcg attgtacgga ctgtatcatc acctaaatga agagcgacct caagcgttaa 3033961 atcaatacct acttcgtttt cacttgcagc tggctgtgaa attttaatcg cattataaat 3034021 ttcaggcaag tgaccgtctt caaaacgcac gtcgacgacc ggtcctaata cctggctaac 3034081 gcgtcctttc ttcatcgcta tccctcctga caaaatcttt ctattctaaa gcggctgctc 3034141 cgccgacaat ttccgtaatt tcttgtgtga tggctgcttg gcgagcgcgg ttgtaagaaa 3034201 gcgaaagtga atcgataagt tccttcgcgt tgtctgtcgc gtttttcatc gccgtcattc 3034261 ttgcagcgtg ctcacttgct ttactgtcaa gaagcgcacc gaagattaag ctttctgcat 3034321 attgaggaag caaaacctcc agaacctcct cttcagatgg ttcaaattca taagacgccg 3034381 ttctttttcc gccgccgctg cccaaatcag ataacggcag aagttttttc tccgttactt 3034441 cttgagtaat ggcgctgaca aaatggttat aaacaaggtg caattcatca aacgcaccgt 3034501 ctataaacat ttgaatcgtt tgacgggcaa gatctttaat ttctgtaaac gttacttcat 3034561 ctccaagtcc tgttaactcg gaaatgatcg gaatctcccg tttcttaaag aaatcacggc 3034621 ccactcttcc gatggcaatc accgcatact catccttaga ctgatgacgt tcttgcatgg 3034681 cctgataagc actccgtaaa accgaactgt taaaagcgcc ggcaagaccg cggtcagacg 3034741 taatgacaag gtatgccgtt tttttcactt ctctgctgag aagcatcggg tgcttcacgt 3034801 tgccggaaac tcttccgacg tttgacacaa cctcttggat tttatccata tatggcacaa 3034861 atgattttgc attgttttca gcacgattca gcttagccgc agataccatc tgcatggctt 3034921 ttgtaatctg acttgttttt ttcgttgacg tgatccttga cttaatatcg cgtaatgagg 3034981 ccaaagattt caccaccttt tctcttcatc tgcgtaaaaa gagagaaaaa gagaaccttt 3035041 ttctctcatc agcattcgag ttagttgctt ggtgcaaatg tgcgtttgaa gccttcgatt 3035101 gcagctttga agtcttcatc agcaggaagg tttcctgttt tcgcaattcc gtcaagcagg 3035161 tctttatggt tttggtcaag gtacatgtag tactcttctt caaaacgtct gatatccgcc 3035221 acaggaatat catcgagata tccttttgtc agcgcataaa gaatagctac ttgcttttca 3035281 accggaagcg gcttgttcag atcctgcttc agcacttcaa ctgtacgcgc accgcggttc 3035341 agttttgcct gagtcgcttg gtcgaggtca gaaccgaatt gagcgaatgc ttccagctca 3035401 cggtatgacg caaggtcaag acgcaaagta cctgatactt ttttcatcgc tttgatttgc 3035461 gctgagccgc cgacacggga tacagacaat ccggcattga tcgctggacg tacgcctgag 3035521 aagaacaaat cagattgcag gaagatctgt ccgtcggtga tggaaatgac gttcgtcgga 3035581 atataagcag agatatctcc ggcttgtgtt tctacgaacg gcagagctgt aattgatcct 3035641 gcgcctttcg cgtcgctaag ctttgctgca cgctcaagca gacgggaatg aagatagaat 3035701 acatccccag ggaacgcttc acggcctggc ggacggcgaa gaagcaagga cagctcacgg 3035761 taagcggccg cttgtttaga aagatcatcg tatacaacaa gaacgtgctt gccgttgtac 3035821 ataaattctt ctgccattgt aaccccagca tacggtgcca ggtacagaag cggtgccggc 3035881 tgtgacgcag acgccgttac aacaattgta taatcaagcg cgccgtgttt acgcaatgtt 3035941 tctactacgc cgcggactgt tgattctttt tggccgatcg caacatatac acagatcatg 3036001 tcttggtctt tttggttcag gatcgcatcg atcgcaacag atgttttacc tgtttgacgg 3036061 tcaccgatga tcagctcacg ctggccgcgg ccgattggaa tcagtgcatc gatcgctttg 3036121 ataccggttt gaagcggttc atgaacggat ttacggtcca taacgcctgg tgcagggctt 3036181 tcgatcggac gagttttgct tgtcagaatc gggcctagtc cgtcaaccgg ctggcctagc 3036241 gggtttacaa tacggccgat taactcttca ccaacaggaa cctccatgat gcggcctgtt 3036301 ctttttactt cgtctccctc acggatctca ctgaaaggtc ctaagatgac gatacctacg 3036361 tttgattcct caaggttttg agccataccc aaaacaccgt ttgaaaattc gacaagttca 3036421 ccggccatac agttgtcaag gccgtgcaca cgtgcaatac cgtcaccgac ttggatgact 3036481 gtacctacgt cttgaacttc aatatcagat tgataatttt gtatttgctg ttttatcagc 3036541 gtgctaatct cttcagcttt gatgctcact taggtttcac cccttctatc gattttcccc 3036601 ggctaattga cgttcaatgc gctgaagctt cccgcttacg ctgccgtcat aaatccggtt 3036661 tccaatgcgg actttaatac cgcctattaa atccgtctgc acttcatttc tgattctcag 3036721 tgaagcgact ccggcttttt ttgcaaacac ttgtgataat ggtaacattt ctgcatccgt 3036781 cagcggtttc actgaatata cgattgcgtc ttctgtttga cgggccacat ttgcgagttt 3036841 gataaactca tctgtgagct cagggacaat cgcggcacga tggcggtcaa tcaaaagaaa 3036901 aatcgtattg agtacggact gtgacaaaga gccaaatgca ttttgaatca gctctttttt 3036961 cttcgcagcc ggcaccttcg gatggttcaa cacatcatta agcgcttttt cattttgaaa 3037021 tacttgtttt acaacaatta gctcttcttc tacttgattc agctgagcgg actcattggc 3037081 tatatcaaaa agagctgatg catatcgttt agagacagct gatccactca tcggctttct 3037141 cctacctctt taagatagtc ctggatcaat ttctcttgcg cttgttcatc cagttctttt 3037201 tcgatcactt tcgacgcaat catgacagaa agagacgcta cttgctcacg gagagcagaa 3037261 accgcctgtt ccttttcctt cacgatttca gttcttgctg cttctttcag acgttcagat 3037321 tctgcacgtg cagcctgaat aatctcttct ttttgcttct ctcccagttt ctttgcgttt 3037381 tcgataagag tttgggattc ctgtcttgct tcttttaaaa gaacgcgctg ctcttcaatc 3037441 agctgctgcg cttctttatt tttttcttca gcagacgtaa tttctccagc gatgtggtct 3037501 tcacgctgtt tcattatgtt taatagcggc cctaaagcgt atttcttcag aagcgctaat 3037561 aagattaaca tagctaacag ttggaacagg atatctccgc cgttaaacga caatcctagt 3037621 tcaagtggta attgagacat ctactacggc aactcccttc tgcaggtttt tctttgctga 3037681 tccagcagcc gcacttgtct cttttcagcc ggcaaggcgg gatgcttatc agacataaag 3037741 caatggcgaa ggttctcttg gaatgatctt cgccattttt agttcatata aggcttttat 3037801 gcttagccaa agaacgctaa gaatgcgata acgacagcga taataggaag ggcttcaact 3037861 aatgcgatac ccatgaacat aagagttctc agttctttac ctgcttccgg ctgacgggca 3037921 atcccctcta ccgtacgtga aacaatcaaa ccgttaccaa tacctgcacc aagtgcgcct 3037981 aaaccaattg caatcgcagc tgctattaaa ttcatgaaaa agttcctcct ttaaaatgtt 3038041 atccgtttgg atataatgtt ttaatgatca tgactgattt tatgagacat gtacaccatc 3038101 gtcagcattg taaagataaa tgcctggata gcaccaataa ataaactgaa tgcttgccat 3038161 gccagcatcg gcagaatggc accgattgta ccgacaagac cgagagccac gctttgcgaa 3038221 taatggcttg ttgctaatcc cgcaagcagg ccgagaagaa tctcaccggc gaagatgtta 3038281 ccatacagcc gcaaacctag agtcagcgta ttcgcaaact cttcgatgat tttcatcggg 3038341 agcatgaatg gaacaggtct taaatagtct ttggaatatt ccttgagccc tttcatcttc 3038401 acaccatagt agtgggttaa agcaacaacc atcacggcta gcgttaatgt aatggcagga 3038461 tcggctgtcg gagacttcca ccagagctca tgtccgattg taatagagaa cggcagcccc 3038521 agcatattcg acacaaatat gtacatcagc aatgtgacac caagtgccaa gaagttagcc 3038581 cctgttttta aatccattgt actgccaata atattgcgga cgaaatcaac aatccattcc 3038641 ataaagttct gggcttttcc gggacggatc gaaagcgttc ttgtcgtcaa tatagcaatc 3038701 aataaaacaa tcacactcgc cacagtaatc atcagaatgt ttgtcagatt aaaagtaaga 3038761 cctagaaatt ctatagttct gtaaccatga ttcaaagggt tttcacctct cttccattga 3038821 tgaacgttta agctggataa aggaatctat cataatgaca gggtatattg tcattaatcc 3038881 aataactgta cttgccatat gaaagtattc gggattttta taggcaacag ccacagcaag 3038941 aatcgcattg caccaccgcg ctgcgctccc gagagatcgt atggactttc ctttctctac 3039001 agctctgtca aaagcattca ttcttctgac gagcagtaaa aaattaaaca aactgaaaac 3039061 agttcccaga ataaggccta aaaaaacggt tttatacgct gttaaaccat aacccagtac 3039121 atacactgcc aaaatgaaca ataaatattt gcgttgtctg ctaaatgtaa gcttgggatc 3039181 gtccatcaat tatctgtctc ctgatgaaaa aataatgtat agcttggata cggcaaaaat 3039241 cagcggttaa cccttagtag aagacctttt ttgaccggca aaacgggcct gttcgaaaaa 3039301 atcattcatc cgcaagcctt gcagggatgc tgtttcattc gcttaaataa atcctcataa 3039361 tacgggtttg ctgagaggat ttacattgag gatgaggact ataatgaaag ctatgaaaac 3039421 cttctcataa taccctcgtt tagcatacaa tagcccctaa catgtgtcaa tctgtttaaa 3039481 gttaaaaaac tttttatact ttacgtctcc acagaatgtt cacattttca cctataattg 3039541 tatacagatt caccgaatag caaaaaactg gataaaaaaa tgaaaccccc ttttggggat 3039601 ttcatttttt attttgttcc aaacatgcgg tcacccgcat ctccgagacc tggaacaata 3039661 tatccttttt catttaattt ttcatctagc gccgcaatgt aaatatcaac gtccgaatga 3039721 tgcttctgca attcttccac accctccggc gctgctacaa gacacatgaa acggatattt 3039781 ttcgcaccgc gttttttaag gctgtgaatg gcttcaactg cggaaccgcc tgtagcgagc 3039841 atcgggtcaa ccacgatgaa ttcacgctct tccacatcag aaggaagctt gacatagtat 3039901 tccacgggtt ttaaggtttc tggatcacgg taaaggccga catgtcccac ttttgccgca 3039961 ggaatcagct ttaaaatgcc gtcaaccatt cccaatcctg ctctgaggat aggaaccact 3040021 ccgagttttt tccctgagat gactttcgat ttcgcagcct gaaccggtgt attgatatcc 3040081 acttcttcca gaggaagatc gcgggtaatt tcaaatgcca tgagtgtagc cacttcatct 3040141 actaactctc taaaatcctt cgtacctgta ttttcattcc gtatatatgt cagcttgtgc 3040201 tgaattaaag gatgatcaaa tacataaacc tttcccatac tgtgtttcag ctcctttttt 3040261 attgtcccat caacaattac acacttctat tgattctaca aaaaaagaca ttgagtttca 3040321 agaacatcgt caaaaaaccc gccgggcata agcccaagcg ggttttagga tcttaataat 3040381 ctaattcttt atataaagga aatttatcag tcagagcagc tacacgctgt cttgcttctt 3040441 caagttttcc ttcatcttcg tggtttttca atgcaagcgc aatgatagca ccgacttctt 3040501 ctaatgcgtc tccgtcaaaa ccgcggctgg ttacagcagc tgtaccaaga cggatgccgc 3040561 ttgttacgaa aggtttttca ggatcatatg gaatcgcgtt tttgttagac gtaataccaa 3040621 tttcatcaag tacatgctcc gcaaccttac cagtcagtcc gagcgaacga aggtcaacaa 3040681 ggataaggtg gttgtctgtt ccgcctgaaa cgagctggat gccctctttc gttaaggctt 3040741 cagccagacg tttcgcgttt gaaatgacgt tttgtgcata tgttttgaaa tcgtcctgca 3040801 atacttcacc gaatgaaaca gcttttgcgg caataacgtg catcagaggg ccgccttgaa 3040861 ttccagggaa gatcgattta tcaattttct tgccaaactc ttcacggcaa aggatcatac 3040921 cgccgcgagg accgcgaagt gttttatgtg ttgttgttgt aacgaaatca gcgtaaggaa 3040981 ccgggtttgg atgaaggcct gccgcaacaa gtcctgcgat atgtgccata tccaccatga 3041041 agtaagcgcc gacttcatca gcaatttcac ggaatttctt aaagtcgatt gtacgaggat 3041101 acgcacttgc tcctgctacg ataagcttcg gtttatgagc gagggctttt tcacgcacgt 3041161 catcgtaatc aatatattga gtttctttat ctacgccgta ctcaacaaag ttatattgaa 3041221 caccgctgaa gttgactggg cttccgtgtg ttaaatggcc gccgtgggag aggttcatcc 3041281 caagtacagt atcgccttgc tccaaaatcg tgaagtacac tgccatgttt gcttgtgcgc 3041341 ctgaatgagg ctgaacgttt acatgctccg ctccaaagat ttccttcgcg cggtcacggg 3041401 cgatatcttc aacgacatcg acgtgctcgc atccgccgta gtagcgtttg cccggatatc 3041461 cttctgcgta cttatttgtc aaaacagatc cttgtgcttc cataaccgct tcacttacaa 3041521 agttctcaga agcaatcaat tcgatcttag tctgttggcg ttcacgctca tttttaatgg 3041581 cgttaaacac ttgttcgtct tgcgcaggta aatgtttcat cagcgagatc ctctcctatc 3041641 cgtatcctgt tctttgtttt taccatcact attgtacatg gtttttaagg ccgatgtaaa 3041701 agattatttt taaaaaatct aaatttttat tggtaaaaac gaatattaat aacttaaatt 3041761 taatttaaag ttcggaattt atttcactat cttaaaataa aagaaaagac tggctatgca 3041821 gtcctttcat tcgcactcat aaaccgcccg cactccgccg attagtttcg gccgtgtacg 3041881 cgccaatgtc acatgagctg aaccgaggct gttttgagag acacgcacag ggacagccac 3041941 cggtttcaga tgcatgccga taaacgtatc gcctatatca attccggcgt cagcctgaat 3042001 ggtttcaaca agaacaggag acttcatctg cttaaacgca taagacgcca tcgctccgcc 3042061 cgcttttgga acgggcacgg cagaaacggt tggaagcctg aacagcttgg ctgtttctgc 3042121 ttcgacgaca agcgctctgt ttaaatgctc gcagcattga aacgccagat ggattcccgt 3042181 tttttcccgg agctcagcaa gtccgctgta gatgctttca gcgatatcta cactgcccga 3042241 tgtgccgatc cggctgccgg ccacttcgct cgtgctgcat ccaaggacga agagctgatc 3042301 ttgtttcaat tccgcttggt cctgaaactc agacagcatc gtcttccacg tttgtttcaa 3042361 ctcattcatt aaacagcacc cctacaggtt tttctcttca taatcggaga tttttccaat 3042421 acgcgtttgg tgtcttcccc cggtaaactc agtagtcagc cagatttttg cgatttcccg 3042481 agccaaacca ggtccgatca cccgttcacc catcgcaagg atgtttgtgt cattatgctc 3042541 cctcgtcgcc ttcgcgctga aggtatcgtg cgccagcgcg cagcgaatcc cttttacttt 3042601 attagcggaa atgctcatgc cgatgcctgt cccgcaaatt aaaatgcctc tgtcaacttc 3042661 gccgctaacc actttttcgg ccaccggaaa agcataatcc ggataatcga cagagccgct 3042721 gccgcagtca cagcccatat caatatattc aatttgcaat tcgtccatta actctttgat 3042781 ttcatttcga atgtgaacgc cgccatgatc cgatgcaatg gctactttca tctgcttttc 3042841 ctcccagcgt gtgtgatgcg gcccgcccgc tttattgacc gcgcagcctg tccgctcttt 3042901 gattcacacc atatgatgtg cttttcacta tattctactc cttcacgcag gatttgcaaa 3042961 tgacctgttt gcagattttc tgacaactta tctacggtct tttttcagct gttttgccag 3043021 ctgccgaaga agctcttcaa gctcatctcg cgtttgttta tagatgtcaa ttgagccgcc 3043081 gaacggatcg aggacatcac catggctgcc tgtgacatat tcttttaacg taaacacttt 3043141 atcacgataa cgtccaaatt ggctggcaat gatctgtttg tgctgatggg tcatagccag 3043201 aaccaaatca gccgattcca taagttcttc agttaatgga gaagacacat gattaagggc 3043261 aatgtgtttt tcaaacagcg cttcgactgc atgaggcgtc gctttcccat taggtgaagc 3043321 aaacacgcct gccgagcgga cattgacatt cagcccttcc ctttctgcaa ttgatttaaa 3043381 aagcgcctca gccattgggc tgcggcacgt atttccagta cagacaaaaa taatatccat 3043441 gtcagtcacc ccttattttt ctctattata tatgaagaaa aaagaaacgg cgacttcgtt 3043501 tcttttattg gtatattaaa ttggcaaaag cagctttaat ccaaacacga ttaatatgat 3043561 gcccccgagc gcttcgctgt atgtgccaag ccatgactgc acttgttttc cgaccagcag 3043621 gcccagccat gtcaacatca tgctgaacag cccgaacagg gtaattgtga ggagcggatg 3043681 cgagccgtat atccccaagc tcaagccgac ggaaaagctg tcaaggctga cgccgatggc 3043741 aaacagcaat aagcccggcc ctgccggtga catgaatcgt tcttctgact gtttaaaaga 3043801 ggccataagc atttgaaccc caagaacaaa aagcagcgcc ccaccgatat aaaccgctaa 3043861 cacgccgagg agccctgaca gcatgttacc ggccgccatc cctgcgagag gcatgatgac 3043921 gtgaaagagg ccgatgatga aaccaatata gaatatctgc ttctttctaa gtttgaccat 3043981 gcccattcca aggccgacag aaaaagcatc catccctaaa gcaaacgcca tgatgcttaa 3044041 tgtaatcagt tcgcctataa acaaatccga catacataaa taaccccctt ggacacgccc 3044101 cgctttttta gcctatgcgt gtccaaaaag ggttagaaca tctgactgct ttcagcgaat 3044161 cactcttcct ccggcggctt tcatcagcct gttcataata gcaagaccga cacctgtatc 3044221 cggaaaggat tccgctataa tgaaatccac cttattctca tcaaagctgc gcaaagcatc 3044281 atacagccct gccgcaacag tctcaagctg agcccgtctt ccgcagctct tcacataatc 3044341 agcggaataa acgcccgctt tttcttctgt cgtcaggaca ccgacccgtc ttccaccctg 3044401 ttgatattct tgaatgaggt gctgaatgcg ctctgggctg ccttcgcaaa tggcaagagg 3044461 cgctgtcggc gcataatgtg tatatttcat ccctggagaa atcggcttct cgttttggtc 3044521 gctgagccct ttatccacat ggatcggccc gatcaccgct tcaatttgtt ccttcgtaat 3044581 gccgccagga cgcaagagaa cagggatgtc gtccgcacat gaaagcacag ttgattcgac 3044641 cccgattccg gtagggcctc catccacaat accggctatg cggccatcca agtcgtgagc 3044701 cacatgctcc gcttttgtgg gacttggctt gcctgataga ttggcgctcg gtgctgcaat 3044761 cggcagtccc gattcgcgaa tcaatgcaag ggcaagcgga tgatccggca ttctaatggc 3044821 aaccgtttca agacctgccg ttacacgagg tgaaagcgca tcaggtttgc aaggcagaat 3044881 gagcgtaagt gctcccggcc aaaaccgttt catcaatgtt ttcgcctttt ccggcgccgg 3044941 gcccgttaaa tcctcaagct ggctgatatc cgcaatgtgg acaatcaggg gattatcgct 3045001 cggccgccct ttcgcctcat atattttttt gacggcatcc gtattttttg cgtttgcgcc 3045061 taggccatat actgtttctg tcggaaaggc aacgacctca ttttctcgga gcaaagcggc 3045121 tgcttgtgca atttgtggat catttgtgga taactcgtca gttacatcca caaaccatct 3045181 tttcgttttc atttctgacc aaactcctta ttcacaacaa taaaacgatt gttttacgcg 3045241 tgtaatcctt ttgaaagtat aaaagatgtc ctgtaataaa acaagcgtta tccacaaatt 3045301 gtggacaacg ctaataaaga agtggataag tatgtgtata aactgcactt atccagacgc 3045361 ttttttcatc aaaacggctc cttctgtttg ccgcgattca cagaagtgat cagaagaaaa 3045421 cagctcctcc ggtacactct cagctctttc aaaacccatg gccgtcagaa agtccgcaga 3045481 ggaatgctga tttgctacta ggtacacggt tttgatctga tgcttttcgc acagcacctc 3045541 catgctttga aaaagcgtga cgatgtggcc ttggtgaagc ttgtccgata tgacaagtga 3045601 tcgcagcagc ccctggtcac agcttatttt ttcaataccg aggcatccgg caatgttttt 3045661 ctcactgtcc tccagcataa gaaattgagt gaagccttct ttcacgcctt catagctggt 3045721 ttttgcctgt tttaaaaatg cctcgagcac atctccgtct ttttcccttg ccacccgcag 3045781 ttgataaaac atccgttcac cccgtttttg cgttctttct tccaatctat gaggcaaatc 3045841 tatttttaga ccagatgatt aggaaaaaag gtcggaaatc cattcgacta aaaagaattt 3045901 cacttctgtg ccgtcttctt tttcttcgtt ctcttctttt ttggcttttt ccgctttagc 3045961 ggttacgtcc tcaagcactt tttcagtctg cttttttgag gcttctttat cttcttgttc 3046021 tttgacggct tccccgttag aaaaatcaag aaagcagagg ggcgggaaca gcacacacca 3046081 ccagttggcg ccgtctccgt ttccaagcgt aatcaaaatc gcttcatact caccagcggg 3046141 atataccatg ttgccgtaaa gctttgtcgg aaacgagatt ttgtcaaaat caacggatat 3046201 cgactgattc gctccttctt tctccattgt ttcctttgca attgctttga tttcaggcag 3046261 ctttgaacga atcacgcgac gcgcttcttc aatagaagta atatccttta cccaagttgt 3046321 gatttcttta ttcaccgcgt ctcttatatg acgttttaat tgctggtctt gatcactatc 3046381 gctgtttgcc agtattctca aacgaatcgc ctgatcaggt atgaccaccg gctgattttc 3046441 cgatttttgt gccgtctctt cttttgccag ccctacgagc gctccggata ataaaagaaa 3046501 gatatatata caaatgatta ctgttttttt catcggtccc caccgttcct ctccgtgctt 3046561 tgtttctagc cctattatgg acaaggagag cctgggataa acgtgcaggg tgaaaaaaat 3046621 ctagcaagct gttaatctta tttatggtac gatagtgttt taggaggttt aagatgaaat 3046681 acaattatac agtgctgtta tcagcattca cgatgtccgt tctttattca gtaatttata 3046741 ttcattcatt tatcattgcc gctctcatca caatggcatt ttattttctg tttccttatt 3046801 tgatcttcgc actgccgctt caaatcatga tgaataaaaa gccgaaacgt ttcagccctt 3046861 tgtatctgct gtattacctt gccgctgctt ttattgccaa cgcgatcatt ttcggcatgc 3046921 ttcagccttc gggacaatct ctgtttcaaa atacagcctt ttatcttttc gctgtattaa 3046981 cagctcttat ctattggata tgggattctg ttttactgca aaaaaaggaa gcctaagagg 3047041 cttccttttt tattaaaaca aaatcgtcag taaataacat agaatggaag gtatcgccgc 3047101 aacaaagaaa gcggccgcca ttttcatgcg agatgtacgg ccttctttgg tttctgaatg 3047161 gtagtttgcc cgctgatcgc ttccgcttac agccaaaccc gatgtaatga tcgcgagccc 3047221 cactaaaacg agagacgcaa cgccaaaaat cgcttcatat gaaagagcct gcggaaaaat 3047281 ggtgccaatc atgctctcaa tcgcaatgag caggattcct gctgtcaggg cctttttcat 3047341 gtttacatcc cctttgctgg tgttaaacag cttgatccat tcactcgcca gcaagctgct 3047401 tatttatttt tatgaatcag agcgcatatg gttctgtctt ttccattaat atctttcagc 3047461 acttccactt ccgccccctt aaacgccttg aggatcaggt ctttgaccgc cgctccctgt 3047521 ttccagccga tttcaaaaac gacaaatact ttatccttca taacaagcgg aatgtcttcc 3047581 ataaaccgct tataaaattt cagcccgtct ccgccatcgg tgagtgcgtg cagcggctca 3047641 tgaaaacgga caatttccga taaatcagcc atttcttcct ctgaaatata tggcgggttt 3047701 gagacaatga tatccgcttt ttttcccgcc ttaataaaag gctcaagcag atcgccctga 3047761 taaaagcgca cattcgctcc gagtttttct gcattggcag aggcgacttg cagcgcctct 3047821 ttcgaaatat cgaccgccga cacagaaaag ctttggtttt caagcgcaag cgtgacggct 3047881 attgcgccgc tccctgtacc aacgtcaaca acttcgagct tgccgtcttc agaaaaaaca 3047941 ctccgatatt tttcaagcaa atgaaagaca acttcttcag tttccggccg cgggatcagc 3048001 acatcatcat tcaccataaa ttcccgtcca taaaaaaact cttttcctat aatgtattga 3048061 accggcacgc cctctttatg catctcaacg tgacgcttaa agcgatacag ttcgtcttca 3048121 ccaatcggtt cctgtaagct tgcgagcagc ttgcttctct ccattccggt atcataaagc 3048181 aataggagct cggccgcatt ttcttctctt cccgcttcgg ttaaataaga agaagcccat 3048241 ttcagggctt cgaatatcgt cttcatctta accttccgac tgctgaagct tgcttgcctg 3048301 atcttcaaca atcagcgctt caaccacttc gtcaagtttt ccttcaagaa tctgatcaag 3048361 cttttgaatc gtcaaaccga ttctgtgatc cgtcacacgg ttttgcggga agttgtatgt 3048421 gcggatacgt tcagagcggt caccagatcc gactgctgat ttccgtgttt gatcatattc 3048481 agcctgggct tcctgctgaa atttatcata gattctggca cggagaacct tcattgcttt 3048541 ttctttgttc ttaatttgag atttttcatc ctggcatgat acaacaacac ctgtcggcaa 3048601 gtgagtcaga cgaaccgcag acattgttgt gttaacgctt tgtccgcccg gtccgcttga 3048661 agcaaatgta tcgacacgga tatccttctc atggatgtcg acctctacct cttctgcctc 3048721 aggaagacat gccactgttg cagtggatgt atggatgcgt ccgcctgatt ctgtttccgg 3048781 aacacgctgt acgcggtggg cgccgttttc atatttgagt ttagaatacg cgccgcttcc 3048841 tgtaatcata aagatgatct ctttgtagcc gcccgttccg gttacattcg cttccatgac 3048901 ctctgttttc cagccctgaa gctcagcata acgggaatac attctgtaca gattgcccgc 3048961 gaataaagcg gcttcctcgc ctcccgcagc cccgcggatc tccatgataa cgtttttgtc 3049021 gtcattagga tctttcggga tcaggagcac cttcagccgt tctgacagtg tttccgtttc 3049081 cttctgaagt tcagaaatct cttccttcac catgtcgcgc atctcagcat ccagcttctc 3049141 ttcaagcatc gcttttgcat cagccagctg ttctgacgca tctctgtatt gtctatatac 3049201 gtcaactgtt tcttgtatat cagattgctc ttttgaatat tctcttagct ttttcggatc 3049261 gttgactact tctggatcgc tcaaaagctc atttaatttc tcgtatcgtt cttcaattga 3049321 ttttaaacgg tctaacacgg tcttcacctc tgttttcctg tgcgtaacat tctcattata 3049381 gtatagtgat taaccccagt caaaagcatt tcaatcccag ctggaaaagc tccctctgct 3049441 atactggaat tcgaggaggg atgatgttgc tgaaatccat acatcatatt gcaatcatat 3049501 gttcagatta cgaaaagtcg aaagctttct acgtacataa gcttggtttt caggtgattc 3049561 aagaaacgta ccgcgaagag cgcggctcct ataagcttga tttgtcgctt aacggctcgt 3049621 atgtcattga gctgttctcg tttcccgatc cgcccgaacg acaaacccgg cctgaagccg 3049681 caggcctgcg ccacctcgcc tttacagtcg gcagcttgga taaagctgtt caagagcttc 3049741 atgaaaaagg aatcgaaaca gagccaatca gaacagatcc gctgaccggc aagcgtttca 3049801 ccttcttttt tgatcctgac cagcttccat tagaactgta tgaacaataa cagtttttga 3049861 agaaaaaaag gagataccca ctttctttgc cgaatctttt cttgttttgt ctaacgggaa 3049921 gggaaccgca ttctatggtc gaatacctag cttaaaagga ggtatgggat catgaataca 3049981 aatatggtag caagtgaact cggcgtctcc gcaaagacgg tgcagcggtg ggtgaagcag 3050041 ctgaatcttc cggccgaacg caatgagctc ggacactatt cgttcacggc agaagacgtg 3050101 aaggttctaa aatccgttca aaaacaaatc tctgaaggca cggcgattca ggatattcat 3050161 ctgccgaaaa gcgctaaaaa gcgcacaggc ttccttgtcc aaaaaacaag tagcgacaca 3050221 gaacgaagaa tcgagcagct tgaacaaaag ctggacaccc ttttacagca aaggcaggac 3050281 gaaagcgaat tgatggcaag gatgtcggaa ctggaacgcc agctgaaaca aaaagccgat 3050341 gaaggtgtat cttaccagct gcttcagcac cgcagagaaa tcgatgatat tcttgcagat 3050401 ctgcaatcac tgacctcaca aatgaaagaa ttcaccgctc attcgatccc cgagactgct 3050461 gctgcttctg aaaaaaccaa aacaagaaaa aaaccgctgc tgtcactgtt caaatttcaa 3050521 acctaaagca aaaagctccc ttaaagggag ctttttttgt tacgcagtaa gcgcgataat 3050581 gattggaagt gaaatcaatg acagaatcgc actgaccaca aacgcagttg cagtttcttc 3050641 ttcttgtttc tcgaaacgag tcgcaatcat ggctgcaacg gcagaaccag ggaatgcaac 3050701 aagaaggatt gcttttgttg tttggtcagc tggaagtccg atagcaagag caatcaggaa 3050761 cattaacgca ggctgaaccg caacttttag taacgcaata ccgatagccg gcatactgag 3050821 tttaatttta cgaataccaa cggtaacacc aacagcgaag agagcaacac cagatgttgt 3050881 gcttccaagc tgatcaagca ttttaacacc cagctcagga agagtgaaat tgaaaaccag 3050941 caccaagatc atactgatta acggagcagc tgcaagcggc tcacaaagac catgcaggat 3051001 tgattttcct gtcatcttcc agaagctgtc gccactctct tcgtttttct tagaagactc 3051061 accaacagta gcgataatga tcgcgagcgg atcaagaatc gcgttaacca cgatacctgt 3051121 gaccgcgatc ggaatcgcaa cttcattcgc tccgaataag cttcccaata ccgggatacc 3051181 cataaatgcg aatgtcggct gtgcagagtt caaagaaaat acagatgagt tcgttaaatc 3051241 atacttgaat ataaatctgc aaaccaaaag aatgatgata tagaaaccaa caatcccaat 3051301 aattaaagaa atcattaaag gtacttgtga taaaaattca cttctggaag ttgtcaaaat 3051361 accagcgata aagtgagctg gaagtgcgta tttcgttact aacgtactta ccccttttgc 3051421 cgacttggca tcataacttc caaaatgtcc tgcaaaccaa cccagcacga taacaaagaa 3051481 gatcggcgcc aggaggatta agatatctaa gatgctcaaa atattctcct ccaaatccta 3051541 tgtccgtata ctttagcttt acaaaaagct ttccctcgga cagaaaaatt tactcgctaa 3051601 ttatttcgcg atgacttttt tgtattcagg tgtccacatt gcatcaagta ccgcttgttt 3051661 cacatcttca ggctgacgat ttgccacgcc gtctttaatt gctgcttcag caacggcaat 3051721 cgcaacttgg atagaaacct cttgaagctt atcaatgctt ggaagcaatc ctgctccagg 3051781 tgtttcaaga tcaaccattt cagcaatcgc atcagcagtt gcagcaaaca tagcaggtgt 3051841 aatgatacgc gcttcagcta caattgaacc aagtccaaga ccagggaacg cgaatgcgtt 3051901 gttagattgt ccgatttcat aagaaacacc gttgtattct acattgtcaa atgggcttcc 3051961 tgttgcaata agcacttttc cgtcagtcca tttgaacaga tcttcaggaa cagcttcagc 3052021 aaggtgagtc gggttagaca tcggcatgat aaccggacgg tctacgtgag atgccatttc 3052081 ttttacaatt tcctctgtga atgcacctga aacccctgaa gtaccaatca agattgttgg 3052141 tttcgcttga cgaacaactt catcgaatgg aatttgacct ttttcatcgc gcttccagtc 3052201 tttcacttca tccgcattgc gaaggtaagg tttttggaaa tcaaggatgc cttcgatgtc 3052261 ttcagtcagc aagcctctgt aatcaagtgt gtagaaacgt ttgttagctt cttcttcaga 3052321 taatccggct agcaccattg tgtcacggat ttggtcagca ataccgatac cagcagaacc 3052381 agcaccgaag ataacaacac gctgatcttt aatagaagcg ccggttttct tcatagcggc 3052441 aagcacacct gcaagtgtaa tcgcgccagt accttgaata tcatcattaa atgtcaggat 3052501 ttcatgattg tattttttca tgatgttgcg tgcatttttg ttgccaaggt cttcccagtg 3052561 aagaagcgct ttagggaaga atttcaatgc agcttttaca taagcgtcaa tgaaagcttc 3052621 gtagcgttca ccttgaacac gttcatgctt gttaccaata tataaaggat cgtttagaag 3052681 tttttcgttg ttcgtaccga catcaagcac aaccgggata acacggctag ggtcaatacc 3052741 agctgcagca gtgtagacag ccaatttacc gattgcaata ttaataccgc ctacacccca 3052801 gtcaccgata ccgagaatgc tttcggagtc agtagcaacg ataagatcaa tatcgcctgc 3052861 tgtcgcatga aggttttcaa acgctttttc aataccgtca atgttatcga ttgacaagta 3052921 gattccttga ggtcttctat attcatggct gtattcctga atcgcttcac caactgttgg 3052981 cgtgtacaca acaggaagca tttcgcgaag atggtttttc agcaatttat agaaaagaac 3053041 ttcgttacgg tttgcaagat cacttaagta aacattttga cgaaggcggt caggctgcgc 3053101 ttggaattgc tcgtacgcgc gttgtgcttg ttgatcaaga gaaagtacag ttggcggcag 3053161 aagcccttct aagccgagtt cttgtctttc ttctagtgaa aaagcaacgc ctttatttaa 3053221 agtaggaata gataaaactt cttttcctct aagagttgtt tctaagtggc cttctttcgt 3053281 tttttttatg ttattcaagc aaatctcctt ctttcttgaa atagttaacc aagttaagta 3053341 ataacccatc taaaatatga ccgatcatga tctttatgcg actttgtgac aattattcga 3053401 acaatgtctc aaaactattt acattacgta agctattgta tgcctgtcaa aatcaaaatt 3053461 caagagaaga aaattactta attttttaat atacttattt aaatttttta attgaatatt 3053521 atcagaatat aaaaaaaaca ccggtgtttt tagccggtgc attctatctt tatacccatg 3053581 ttttggacta ttttttagat ttacctggga cttcgtgatg atgtctgcat cttgcttcat 3053641 atgattcagc tgcaccaacc aaaatgaccg gatcatcgta agaagcaggt ttgccgtcaa 3053701 tgaggcgctg tgttctgctc gccggtgatc cgcaaacaga acagacggct tgcagctttg 3053761 tcacactttc cgcaatcgcc atgatattcg ggacgacacc gaacggctct cccctaaaat 3053821 ccatatcaag gcctgctgct atcacacggt agcctttatc ggcaagagat gataaaacct 3053881 caacaatttc ctgatcaaaa aactgcactt catcaaccgc aaccacatct gtactttcac 3053941 tgatgtgatc ccaaatgtcc gcagcagacg aaatggcata gctcgtcatc gatgttccat 3054001 tatgggagac aacagcagct tcgctgtatc ggttatcaat tacaggctta aataccctga 3054061 cttcctgctt ggcataagtt gctctcttca ctcttctgat cagctcttca gatttccccg 3054121 agaacatgct gccgcaaatc agctcaagcc acccgctttg tttcattatg tacataggct 3054181 tcgctcccct ctctctgcca gctgtgtttt agacaatata aaaaacaggc aagactgctg 3054241 cttgcctgtt gagaaatcta ttattactta agaccgtatt ttttgttaaa gcgatcaaca 3054301 cgaccatcag cagaagcgaa tttttgacgg ccagtgtaga atgggtggca ttcagagcaa 3054361 atctcaacgc gtacctcttc ttttactgag cctgtttcaa attcatttcc gcaagcgcat 3054421 ttaactgttg cttttttgaa attaggatga attcctgctt tcattgtatc catctccttc 3054481 cgccctgaat cccgtgtgga aacagagtta ttatttcgga gcattgtccg aaacgcatat 3054541 gagaaaatta tatcagtgat ttacttcttt tgcaaataca atttaccttc ttgcagatga 3054601 tagatttgcc tgtttccatt cttgattgag aatatcgaaa aattcctggt ttgttttggt 3054661 ttttttcatt tttctcatga acttttctgc gaaatcaggt gaatcagaca tcgttttgcg 3054721 gatagaccat aaacgatcaa gatgctcttt aggcacaagc agctcttctt tgcgcgttcc 3054781 tgaacggcgg atatcgatgg cagggaagat gcggcgctcg gcaagagagc ggtcaagatg 3054841 gagctccatg ttgcctgttc ccttgaattc ttcataaatg acatcatcca tacgtgaacc 3054901 tgtatcgacc agagccgtag caaggatggt taagctgccg ccctcttcga tatttctcgc 3054961 agccccaaag aagcgtttcg gacggtggaa cgccgctggg tcaatccccc cggaaagcgt 3055021 tcttccactt ggcggaatca ctaagttgta ggcgcgggca agacgtgtga tgctgtccat 3055081 caggataatg acgtcttttt tgtgttccac gagacgcatc gcacgttcaa gcacaagctc 3055141 ggccactttg atatggtttt ccggcacttc atcaaacgtt gagctgacga catccccagc 3055201 tacagagcgc tcgatatcgg ttacttcctc aggtctttcg tcaattaaaa gcacgatcag 3055261 ctctgcttca ggctggttcg ctgtaatgct gttggcaatt tccttcagca acatcgtttt 3055321 tccggctttc ggcggcgcaa caatcaatcc gcgctgccca aatccaaccg gcgccatcat 3055381 gtccataatt cttgtagaca agaagttcgg ctttgtttca agcaccattt gacgatccgg 3055441 ataaagtggc gtaagagccg ggaaatgcac acgctctttt gcagattcgg gatcatcccc 3055501 atttactgct tcaacgtgca aaagtccata gtaacgctca ttttcttttg gcgggcgaac 3055561 cttgccagat actttgtctc cgttccgcaa atcgaaacgg cggatttgtg aagctgagat 3055621 gtaaatgtct tctgagcttg gagagtagtt gatcggtctc aggaatccga aaccttcaga 3055681 ctggatgatc tcgagaacgc cttccataaa cagcagatct tcctgttctg cattcgcttt 3055741 cagaatggcg aaaatgagtt ctttttttgt cagtttgctg taataggaga ttttataatg 3055801 tcttgcaagt tcataaagct ctttcaattt catattttcc aaagaggaaa tagatacgtc 3055861 tttcataaaa acaccacgct tttcatagtc aatatcttac tctgaacatg tcatctgctg 3055921 cttttgcaca acatccgcca aagcacattc tttttttaac ataaaggaac ttctatcggt 3055981 aacacttcca cccatgatcg gcgcttttgt taaaaggatt gtcttaatga gttttgaagg 3056041 aagcgaggac aaaaacatga gaagatcaat acttatatcg tctgtatgcg gtagaaattg 3056101 aaactttcct agtgcttaaa agaaggtatt acgcagtaaa attcgcagca ctctttattt 3056161 ttaccttatt tcaaaaaatt attcaactga aataaggttt tgacacggaa ttgatagagt 3056221 tgacgctttt ctgcaaaagt taaagcgggc tcacacccgc tttttctgtt tgttatggac 3056281 ggattacaag atttggtttc tttttcaagc tgtgtctgcc gtcaacgaaa cgaacagtgc 3056341 ccgattttgc acggataact aagctttcag ttgtaccgac agagcctttg aattgaactc 3056401 cttttaacag ctcgccgtca gtaacccctg tagctgcaaa aatcgcgtca tcacccttca 3056461 caaggtcttc catgcgaagc actttgctta aatcaaggcc cattttgtga cagcgagtga 3056521 tttcttcttc gctttgcgga agaagtttac caatgatttc tccgccgagt gcttttagcg 3056581 caacagcgga aagcacaccc tcaggagcgc cgcctgatcc gaacaggata tcaacgcccg 3056641 tgtggtcgaa agccgtgttg atggcgcctg cgacatcgcc gtcattgatc aatttgattc 3056701 tggcgccggc ctcacgaagc tcggaaatga tttttgcgtg tctttcacgg tttaaaattg 3056761 tggcaacgac gtcctcaacg tccttgtttt tcgcttttgc caccgcttta aggttgtcaa 3056821 tgacaggtgc ttcgatgtca atgcagccca ccgcttccgg accgactgcg attttttgca 3056881 tatacatgtc aggagcattc agaagcgtgc catggtctgc gaccgcgata accgtcagcg 3056941 cgttccagcc gccgcttgct aagatgtttg tgccttcaag agggtcaact gcgacatcaa 3057001 cgcgagggcc gtacccgttt ccgagttttt ccccgatata cagcattggc gcttcgtcca 3057061 tttccccttc accgattaca acggtccctt tcatcggcac tgtatcaaaa acgtctctca 3057121 ttgcacttgt tgccgcttca tcagcctcat ctttttttcc ccggcccatc catcttgctg 3057181 atgccaatgc cgcagcttct gtcacacgta ccaattccat tgataaactt ctttccattt 3057241 caacacgatc tcctctcaca agaaaccatt atgaattttg aagctgttct atttcttcgt 3057301 cagtcattct ttcacgccaa attgtcgctc caagcccctc aagcttcttc tcaaggctgc 3057361 tgtatcctcg gtcaatatgc tccagtcccg taatttccgt gacgccatca gccatcagtc 3057421 cggctaccac caagcaggct ccggcacgca gatcactcgc cttcactttt gcgccttgaa 3057481 gctcgacagg acctgtgatg atggcagatc tgccttctac tttcatattg gcacccattc 3057541 gtctcagctc atcaatgtgc ttgaatcttg ccgagtagat ggtgtctgtg acgacactcg 3057601 tccctttcgc ccttgtcagg agcgccgtca tcggctgctg taaatcagtc ggaaaccccg 3057661 ggtatacgag ggttttgacg tcaaccggct ttaagttctt ctgcccgccg acaatgagga 3057721 gctggtcgtc gcttgtttcg atatgatagc ccatttctct cagctttgcc gttaacgact 3057781 caagatgagt agggatgacg ttatcgataa tgacttcctt gcccattgca gcccctgcaa 3057841 tcataaatgt cccggcttca attctgtccg gaatgatcgt atgcttgcag ccgtgcagtt 3057901 ccttcacgcc gtcgattcga atcacattgg tgcccgcacc tttgattttg gcgcccatgc 3057961 tggtaagcaa tgtcgcgacg tcaatgatct caggctcctt ggcagcgttt tcgatgatcg 3058021 ttttcccttc tgccaaaaca gcggcgagca taatgttaat cgttgcccca acgcttacga 3058081 catctaaata aatccgtgcg cctctcagcc tttcagctcg caaataaatg gcgccttgtt 3058141 cattggttac ttcagctccg agtgcttcaa agcctttgat atgctgatca atcggacggg 3058201 gccctaagtg acagccgcca ggcaatccaa tgaccgcctg cttgaagcgg ccgagcatcg 3058261 cccccattaa ataatatgac gcgcgaagct tttttacttt cccgttagga agcggcatgc 3058321 tgatcatcga cgtagggtca acaaccattt ccccattctc aaaatgcacg ttgccgccga 3058381 tttcctttaa caggtcacgc agcgtttcaa tatctgaaat ctctggaagc ccttcaattg 3058441 tcacctcgga atttgccaaa atggttgcag gtattaacgc aacagcgctg tttttagcgc 3058501 cgctgatatg tactgtaccg tttaacgagt caccgccggc aatattcaac ttttccatga 3058561 tagtctcctt ccataagaag atagctgcgg agctaaataa aatgtcattt tattctgtct 3058621 ctgcaaataa agctcatgtc caaaatctag ccaattcgaa gagaaagaat acaacacatt 3058681 gtaaaatatc aggaagaaaa tagcgaagct ttggggggta caggtttcaa aagatgcaca 3058741 gagacccgcc ggctcgagag acatcgtcgt catccggcaa aagcagtacg catacccttc 3058801 attccgatat cagcttctgc agcccaatga ttccttctct gtaaagcggc gtcagcatct 3058861 gaagatccgc tgtatcaggt cggtgaaata caaaggccgc ggcaaacagg cataaagctg 3058921 tttgccgccc ctttcattat ttgttccagt ctgccaggaa ttgttcgatt cctttgtctg 3058981 ttaacgggtg tttagtgagc gcatgaatga ctttcagcgg cattgtgccg atatgagccc 3059041 ctctaagagc agcttctgtc acgtgctgcg gatggcggat tgacgctgca atgatttgcg 3059101 tgtcaaggcc gtgaatgtca aaaatctgtt taacttctga aatcaggtca agcccgttgt 3059161 ggccgatgtc atctaaacgt cccaggaatg gagatacata tgttgccccc gctctggcag 3059221 caagaagcgc ctggttggca ttgaagatca atgtaacgtt tgttttgatg cctaagtcag 3059281 taagtgctct taccgctttt aaaccgtcag acgtcattgg gattttcacc gtaatgttcg 3059341 gagcgatctt cgccagttct tttccttcct cgatcatttc ctcagctttc aaagaaataa 3059401 cctctgcgct tacagaccct ttcacgacgt ctgtgatctc gcgaagacgg tcgtggaatg 3059461 atacgttagc ttcctttgct actaaactag gattcgtcgt tacaccggcg agaattccta 3059521 attcattcgc ttctctaatt tcatcgatat tggctgtatc aacaaagaat aacattttca 3059581 aaaagcctcc ctgattaaga aattttctga actgcgaata tgattgcgct ttctaaagat 3059641 agacggaaaa ccgcctgtca agctgtcagg cggctataaa aagttccaat tgaattaagc 3059701 ttggtttgaa gaaccaaatt cacgcatttt accgataact gtttctttga tcgcttcacg 3059761 agctggtcca aggtatttac gtggatcgta ctcgtcaggc ttagctgcca atgtttcgcg 3059821 aacagctttt gcagaagaaa tttggttttc agtattcacg ttgattttag ctgtaccaag 3059881 tgaaattgat tttttgatgt cagcagtcgg aattccagta ccgccgtgaa gaactagcgg 3059941 aaggccagtt gattttccga tctcttccat ttctttgaag ccaaggtttg gctcaccttt 3060001 gtaagggccg tgaacagaac ctaatgcagg tgcaaggcag tcgatgccag tgcgctcaac 3060061 aagctcttgg cactctttag gatcagcgta gattacgcct tcagcgataa cgtcatcttc 3060121 ttgtccgcct actgttccaa gctcagcttc tacagatact ccgtggaaat gagcaagctc 3060181 aacaacttta gcagttgttg ctacgttttc ttcaaatgga tggtgagaag cgtcgatcat 3060241 tacagatgtg aaacctgcat gaatcgcttt cgcacaagat tcaaagcttg aaccgtggtc 3060301 taagtgaatc gcaacaggaa ctgtcacttt gtactcttcc ataagtgctt ttaccatagc 3060361 aacgactgtt ttgaagccgc ccatgtagcg tcccgcacct tcggaaacac caaggatcac 3060421 tggagatttt tcttcttcag ctgcttgtaa aatcgcttga gtaaactcaa ggttgtttaa 3060481 gttaaattgt cctacagcgt accctttttc tttagctgta ttcaacattt ccgtcataga 3060541 aactaaaggc atgtcgaatg tcctccttat gtagcctgat tgtcttctag cgaaaaaagc 3060601 tttccaccct agcatgaccc atatattgct gtcatatgta aatactcaga tcgctttttc 3060661 tccataacta ggataccaac ttttcgacaa atcggcaaca taatgacatg attcatttgt 3060721 ttcttctttt tgtcagttag acttcagggg cagatatttt ttgacggcgt ctctgatttc 3060781 gtcgatgtca aacggcttgg caaagtgcgt cagagcgccc aattccttcg attcctggat 3060841 catgtcgagc tctccgtatg ccgtcatgat aatgacccgg atgttttcgt caatgacctt 3060901 catccgtttt aagatttcga ttccgtccat gccgggaatt ttcatgtcca acagcacaag 3060961 gtcgggccgt tcttttgtca caatgtcaag cgcctgcagg ccgttcgcag cctgaaacgt 3061021 ctggtagcct tctttattga acacttcatt tagcaaaata cgaatgccgt attgatcatc 3061081 aacgattaaa attttttcat tcatcatttt acaccccaat attatgattt tcgtcaaaag 3061141 taagcagtat tgtatgtatt ctgtttgatt ttcctatttc ctttaattat aatagtctac 3061201 tttacgacat tttctgagca ttttctcttt tgttgtatac tgatattgta cgttataaag 3061261 gaggattcac ttatgttgaa aatattcacg acgcagttaa caggtatttt ttcccgcatt 3061321 caggataagg aatctgacgc gattgaagat ggggcgcggc tgcttgctca agcggtgatc 3061381 agcgggcatt ccatttattt atacggagcg aatgagcttc agggcgtctt ttatgaggcc 3061441 accgaaagca aagaaccctt cccatctgtc aaagcctttc cagaaaacgc tgaggaagtg 3061501 acagaaagcg acagggtgct gatgttttgc tcagggacgg gcacagccga agaacaggag 3061561 ctcgcaaaag agctttatga aaaaggtgcg ggagtcgtat gcgtatcgcc cgcagccaaa 3061621 gacagtgcgg gaatagaaca gtattgtgat gtgcatattg attctaaatt aaaaatgccg 3061681 cttgttcccg atgaagacgg cacccgttac gggtttccct ctttaatgac agcactgtat 3061741 gtctatcacg ctttatcgtt tacactaaaa gaaattctgc aagagtatgc ataatatctt 3061801 attgtacatg ctggaacttg ccggaaacaa ataaaaaaga cttgcccgct tttgacaaac 3061861 ggcaagtctt ttttattact tctgatttgc agcttcgaca gacgctccga taaagccttt 3061921 gaatagaggc tgaggtcttg tcggtcttga cttgaactct gggtggaact gagaagccac 3061981 gaaccaaggg tggtctttca gctcgatgat ttcaacaagg cgtccatcag ggcttgtgcc 3062041 tgagaatacg aagccttgct cttccatttg ctgtctgaat tcattgttaa actcatagcg 3062101 gtggcggtgg cgctcgtaca ccacttcatc ctgatacact tcaaaggctt tcgtgccttc 3062161 ttcaagctta caagggtaaa ggccgagacg aagcgttccc ccaagatcct caacatcctt 3062221 ttgttcagga agaagatcaa tgatcgggta ttgagttgac ggatcaattt ccgctgagtg 3062281 agcgcctttt aagcccaata cgtttcgtgc gtattcaata gacgccacct gcatgcccaa 3062341 gcaaatgccc aagaacggaa tgttgttttc gcgcgcgtat tttgtcgcga cgattttccc 3062401 ttcaacaccg cggtctccga atccgcccgg cacaatgatg ccgtctgttc cgcttgtgag 3062461 ttctgcgata ttgttttctg tcacttcttc cgcgttgatc cacttcactt ttacatctgt 3062521 gtcaaacgca tagcccgcat ggcggagaga ctcgacaaca gaaatgtatg cgtcaggaag 3062581 ctcaacgtat ttgccgacaa ggccgattgt aatcgtttga gacaggttgc tgactttgtt 3062641 aacaagctct ttccactcgg acatttccgc ttctttgcat gccaatttca tgtgctcgca 3062701 aacaagctta tcaagccctt gtttttgaag ctccagcgga atggagtaaa ggttgtccgc 3062761 atcttcacat tcaataaccg cttttgtatc gatgtcgcag aaaagcgcga ttttatcttt 3062821 catatcttga gaaatcggca tttctgtacg aacgacgatg atgtttggct gaatgcccaa 3062881 gctgcgcaat tcttttacgc tgtgctgtgt cggttttgtt tttaattcgc cagcagcttt 3062941 aatgtaaggc acgagcgtac agtggatgta cattacgttt tcacggccga tgtcgctctt 3063001 catttggcgg atcgcttcaa ggaatggcag tgattcgatg tctccgacag taccgccgat 3063061 ttctgtaatg acaacatctg cgtttgtctc tttccctgcg cggtaaacac ggtctttcaa 3063121 ttcgtttgtg atgtgcggaa tgacctgtac ggttcctcca aggtaatctc cgcggcgttc 3063181 ttttttaaga actgttgaat agattttacc tgttgtcacg ttgctgaatt tattcaggtt 3063241 aatgtcgata aaacgctcat agtgaccaag gtccaagtct gtttcagcgc cgtcatccgt 3063301 tacgaatact tcaccgtgct ggtacgggct cattgttccc gggtcaacgt tgatgtatgg 3063361 atcgaatttt tgaatcgtca cgttcagtcc gcggtttttc agcaaacgcc ctaatgaagc 3063421 tgctacaata ccctttccaa gtgaggatac aactcccccg gttacaaaaa tatatttcgt 3063481 catttcgttt gctcctctct tcgctcttag ctacattttt aaaatgtact attttataaa 3063541 aaatcattta gccttttaaa tgatttataa gaaaaatgag gggtgaaaat aagaaagctc 3063601 cctttcaatt tcttgaaagg gagcataacg tactatgttc tctcttcgtt tttgaagagc 3063661 ccaaaataca tactacatag ttcgactatg aaagtcaaga tcgttttgaa gatgaaatct 3063721 gatactattt aatttcctct tcttcatcat catagtcttc atcatcttca tcaataatat 3063781 cttcttcgat ctcaagatca tcgtcgtctt catcaagatc ttcttcgtca aaatcgtcgg 3063841 cttcaagatc gagttcttcc tcaacttcat ccaaatcaag gtcgtcttcg tcgatctctt 3063901 caaactcgtc aagatcaaga tcttcttcga ctgctttctt cgcttttttc tttttcgcct 3063961 tgactgtcgg ctgagtttct tcatcaagct gatcataagg ataccagctg cgaagccccc 3064021 acgtctggtc agaaagcgcc aggaagcggc cgtcaatgtt taaatctgta taaaattgag 3064081 caatgcggtc tccaagctct tcttttttca cgccgagcaa agatgcgatt tcatttaaaa 3064141 gctcctgaaa aggaactggt tttttatgtt cttcaaataa ttcgtgagcg atttcaacta 3064201 aagccatttc ctttagctct tcctgtgaat attgtttgat acccaaggtc ggacactccc 3064261 tttctattac ttatatgtat ctgttttatc aataatgaaa gcgattttgt atcgttctta 3064321 tacaaaccat acctctcatt ataaacaaaa taaaacagaa tatgctaccc ttaacagcgt 3064381 taatttaaat aattttacaa gagtgatccg actgagagat gttttccgtt aatccgcgag 3064441 cattctggag atgaccagtc tttgaatttc ttgagtgcct tcatagattt gcgtgatttt 3064501 tgcatcacgc atatagcgtt ctaccggata atcttttgta tagccgtagc cgccgaaaat 3064561 ctgcacggct tcggtcgtta ccttcatcgc cgtatcccca gccatcagtt tggacatggc 3064621 ggaagctttt ccatatggaa ggcccgatga ttctaaccat gcagcctgat aggtcagtag 3064681 ccttgaagct tctatcattg tcgccatatc cgcgagttta aaagcgatgc cctgctgctc 3064741 ggcgatcgat tttccgaatt gctttcgctc ttttgcatat tgaagcgccg catcaagcgc 3064801 tccttgggcg atgcctacag cttgtgcagc tatgccgttt ctgcctccgt caagcgtctt 3064861 catcgcgatt ttgaagcctt ctccttcttc tccgagacgc tttgatgcgg gcactacaca 3064921 atcttcgaac atgatttccg ttgtcggtga agaacggatg cccagcttct tttctttctt 3064981 gcctgtaaaa aatccttcaa aatccttttc tactataaaa gcggtaacgc cttttttctt 3065041 tttctcggga tcggtgacgg caaaaacaat gtaaatatca gcaacgccgc cgtttgtgat 3065101 aaacactttg gaaccattta acacatagtc atcgccgatt cgttcagcag ttgttttcat 3065161 gctgccggcg tcagagccag accctgcttc ggtcaaagcg aatgcgccga ttttctctcc 3065221 gagagccagc tgtgttaagt actctgtctt ctgttcctct gtcccaaagg caaacagcgg 3065281 ccagctgcaa agagagatat gggcggaaag cgtcacaccg gtggaggcgc acacttttga 3065341 cagctcttcc accgcgatga cgtaggctaa atagtcactt ccaattccgc cgtaatcttc 3065401 aggccatgga attcccgtca ggcccagatt tgccatttcc cgaaacagct cgcgatcgaa 3065461 gcgttcttgt tcgtcccgtt cagccgctgt cggggccacc tcatgcttcg caaaatcgcg 3065521 caccaatttt cgtatcatct catgttcttc tgataatgaa aaattcattg cttctccccc 3065581 attttcagat cagcgcctaa aacggattga gccagaagct cgacgacgtc gtacgttttg 3065641 acttggtctt cggcttcctt cgcctttgtg ccgtccccaa gcatcgtgag acaatacgga 3065701 cagccagaac tgatcaccga tgggttgact gcgagcgctt gctctgtcct ggcgacgtta 3065761 atcctgttgc ctgtttcttc ctccatccac attaatcccc cgccggctcc gcagcacatg 3065821 ccggtttccc ggcttctctc catttcaaca agctgcacgc ccggaatggc tttcaaaatc 3065881 tctctcggcg gatcatagac ttcattgtac cggcccaaat agcacgaatc atggaaggta 3065941 atcgtctcat gaagcgggtg ctgcggtctt aattttccgt ttttcacaag ctcggccagc 3066001 acttctgtat gatgataaac ctcgccttca aatccgaaat ccggatattc gtttttaaat 3066061 aaattgtatg catggggatc gatcgtaacg atttttttga catcattttt ttcaaattca 3066121 gaaatattct tctcagccag ctcttggaac aaaaattcat ttccgaggcg gcgcggcgtg 3066181 tctcctgaat ttttttcttt attgccgaga atcgcgaagg acacgcccgc gtgattgagc 3066241 agcttggcaa aggaaattgc gattttctgg cttctgttgt cgtaagaccc catggagcct 3066301 acccagaaaa ggtactcaaa ttcttttcct tcttttttca tttcttttac agtcggaatc 3066361 tcagcatccg gcgcctcgtc acgccaattt tcacgttcct tgcggttgag tccccacgga 3066421 ttcccttgcc gctcaatact tgtcattgcg cgctgggcgt cactgtccat ttttccttct 3066481 gtcagtacga ggtagcggcg gaggtcgatg attttatcca cgtgctcatt catgaccggg 3066541 cattgatcct cacagttccg gcaagtggtg catgcccaaa tttcttcctc tgtgatgacg 3066601 tcgccgatca agcttggatt gtaatcaagc gccgctgcgg cttcctgcga tccgctgccc 3066661 gctgacgccg cagccagctg attgcctctc gtatgccgaa acgctgctgc gggcacccat 3066721 ggggagcgcg aggtgacggc agcgcctttt tccgtgagat ggtctctgag acgcaaaatc 3066781 aagtccatcg gagaaagcat ttttccggtg cctgttgcag gacacatatt ggtacagcgg 3066841 ccgcactcga cacacgcgta tagatcaagc agctgagact gtctgaaatc ctcaattttt 3066901 cccgctccgt agctttcttt cgtttcgtcg gtaaaatcaa ttttttcaag ttttccggca 3066961 gattccattc gattgaaaaa gacgtttgcc gggccggcga ttaaatgggc atgctttgac 3067021 tgaggcacgt acactaaaaa gctaagcaag aataggagat ggatccacca tgcgatatag 3067081 aaaatcaccg ccgcgcctgt tttcccgaca ccgctaagca taaacgcaat acctgaggca 3067141 attggctcgc tccaagaaag cccatgctca tgccaaatca gattcatccc gttcccaagc 3067201 agaacggtca gcattaatcc tccgataaaa atgagaacga gtccggcttt gaaaccgcgt 3067261 ttcagcctca cgagcttttc gatataacgt ctgtagaatg cccacccaac agcaattaaa 3067321 atgagaaacg taacaatttc ctgaaaaaag gtgaaggcgg gatagaccgg gccaagcgac 3067381 agattccggc cgggagccag tcctttgatg ataaagtcaa ttgctccgaa ctgaaccaat 3067441 ataaatccgt agaaaaacat gacgtgaatg attccgcttt tcttgtcctt gagcagtttt 3067501 ttctgtccga atacattcac ccatatggcg tgaagccgtt ccttgaaccg ttgatcaaat 3067561 tgttctttct ggccgagctt gatgtaggcc agtctcgttt tgaccaagta aacaaacaaa 3067621 tagacagcgt aagcggttac aatcagaaat aataatgcat ttgcgatgag aaagccgctc 3067681 attccaattc ccccttttta ctgataaaga ccgcgatccc ctacccccga atctgtataa 3067741 gattatcttt atgataaata atgaatgagt gttcagtcaa taattaaatt cctgctgttc 3067801 gggcacacta cctttactac ggaaaggagt gccggtatga aggtatttat cgtgattatg 3067861 atcattgtcg ttattttctt tgccttgatt ctgcttgata tcttcatggg ccgtgccgga 3067921 tacagaaaaa aggcgtacga gcctgttttt tcaaaaaaga agagtgacat cgaattgatc 3067981 cactgcggcg ctgatctcgt tgagcggatg atgaatgata ttcgccaggc cgcctcttct 3068041 gttcacatga tgttttttat tatgaaaaat gatgaggtca gccacaatat gtataccttg 3068101 ctgaaaacaa aagcccaagc tggcgtatcc gtttatttgc ttctggattg ggcgggctgc 3068161 cgggcaatta aaaaaacggc gcttcagacg atgaaaaatg ccggcgtcca tgtccatgtg 3068221 atgaatcgtc cccgttttcc ttttttcttt tttcacatgc aaaaacggaa tcaccggaag 3068281 attacggtga tagacggaaa aatcggttat atcggcgggt ttaatatcgc cgaagaatat 3068341 cttggaaaga aggcgaagtt cggcaattgg gaggattatc atctgcgcat gatcggagaa 3068401 ggcgtacatg atcttcaaac gctttttgct tctgatctaa aacgaaatac cggaatcgaa 3068461 ctgggttcgg atgtttggcc aaagcttcag caagggacta tttctcacaa gatctatgcg 3068521 accgacggtt attcccttga aaacatatac ttggccaaca ttgcccaagc gaagaatcgc 3068581 cttacggttt gcacgcctta ttacattcca tcaaaaccgc ttcaagaggc ccttattaac 3068641 gcaagaaaaa acggcgtatc cgtgagaatc attgtaccga tgaaatcaga ccatccgctg 3068701 gtacgagaag cggcttttac gtattattcg gagctcttgg atgccggctg tcttatttat 3068761 cgttattatc aagggtttta tcatgtaaaa gccctcatca tagacgacca tctcagcatt 3068821 atcggaacag ccaacttcga taaacggagc ctgttcttaa atgaagaggt gaatgttgaa 3068881 attgatgacg aagcgtttac aagtgaagtc tatgccacaa ttgaggagga tatgaaaaag 3068941 tcggagctgc tgacgatgga ggatttcagc aagcgcacat tcaggcagcg cccggcggaa 3069001 tggctcggca gggcattatc ttatttctta taaaggagag ttcctatgat tttcagattc 3069061 gggttcgttt caaatgcgat gagcctttgg gatgcgtctc ccgctaaaac attgacattc 3069121 gcgcgttatt caaagctttc aaagactgaa agaaaagaag cgcttctgac tgtgacaaaa 3069181 gccaatttgc gcaatacgat gagaaccctt cactatatca tcggccacgg cattcctttg 3069241 taccgttttt ccagttcgat tgtgccgctg gctacgcatc ccgacgtgat gtgggatttt 3069301 gtaacaccgt ttcaaaaaga gtttcgggag attggagagc ttgttaaaac ccatcaactg 3069361 cgaacaagct ttcatccaaa tcaattcact ctgtttacga gcccgaagga atccgtcaca 3069421 aaaaatgcgg taacagatat ggcgtatcac taccgcatgc ttgaggccat gggcattgct 3069481 gatcgctccg ttatcaacat tcatattggc ggcgcttacg gaaataaaga caccgccact 3069541 gcacaatttc atcaaaatat aaaacagctg ccgcaggaga tcaaagagcg gatgacactt 3069601 gaaaatgatg ataaaacata tacaacggaa gaaacgcttc aggtctgtga gcaggaggat 3069661 gttccgtttg tctttgactt tcatcatttt tacgccaatc cagacgatca cgccgacctg 3069721 aatgtagcac tgccccgcat gatcaaaacg tgggagcgga tcggccttca gccaaaggtt 3069781 cacttgtctt ccccaaaatc ggagcaagcg atacgcagcc acgccgatta tgttgacgcc 3069841 aactttttgc tgccactgtt ggaacgcttt aggcaatggg gaactaatat tgatttcatg 3069901 attgaagcaa agcagaaaga caaggcgctt ctccgcttga tggatgaatt aagctccatc 3069961 cgcggtgtca aacgcatcgg gggcggtgcg ctgcaatgga agtcataaat gtgcaaaaat 3070021 aggtttacga cttgtcagct ttgggaactt aggctatata agacaacaat cgatggagga 3070081 gaaagatcat gaaaaatatc aagtctctga aagtagccgc acaggccttt actttaagaa 3070141 atttgattca tctttataaa atgtgccatt ccggaagcca cgaggtttat atttattcaa 3070201 agaaaacgat gtgcaaaatc aaaagcttaa ttgagcttga aacgttccgc atggctcata 3070261 atgaaaagga atatctgatc gtagttgaag gaacaaaagc atcacagctc attgaaaaat 3070321 tccaaaatct catcgagcct gctgagagag aagcgctcta acttacatac aaaaaaggat 3070381 agacatctgt ctatcctttt tcttatgctc ttacataatg gagctgaacc gcttgtccaa 3070441 attgttttgt cccttttaac cgcagttttg tttcatttgt tagttcgtga aacagcggga 3070501 tgccgcttcc taaaacgacg ggaataacag tgatgatgaa ttcgtcgatg gcatcttctt 3070561 tcataaagtc attcacaagc tctgccccgc cagctatcca gatgtttgag cctttttcct 3070621 gtttcaaacg ggcagtgaag gctctggctc cctcattgat aaacgtcaca tgttcatctt 3070681 gataactgtc gggcgatcct gtaaaaacat agcaggtttt atcctgatac gggaaaaccg 3070741 gtgttagcac tttaacgtgc tcatatgtgc tccgccctaa aatgactgta tcaacagtct 3070801 gataaaaatc actgtagccg ttgtcacctt caccttcaaa ttcatccagc caatcgatgc 3070861 ttccatcttc ttttgcgatc atcccgtcca atgaaacagc aatgtacagc acagtttttc 3070921 tttccatgtt ctcctcctat cgatgcacca tttgcccgaa ttgcgcttga tgcagcctgc 3070981 tgtataggcc tccggcttcg atcaggtctt gatgacggcc ttgttcttca ataccgttgt 3071041 ttgtgacgac tacaattctg tccgcgtctt tgattgttgc cagcctgtgg gcgatgacaa 3071101 gcgtcgtgcg cccctcagac aactcttgaa gcgccttttg gatcgccgct tccgtctctg 3071161 tatcaagggc tgaggtggct tcgtcgagaa tcaagatcga cggatttttc aagaacatcc 3071221 ttgcaattga cagacgctgt ttttgcccgc cggaaagctt cacgccgcgt tcgccaatca 3071281 tagtatccaa cccatcgggc atgttatgga cgagctcttc cagatgcgcc tgcttcacag 3071341 cttgccaaat gtcttcttct gatgcgccta gtcggccgta ggcgatattt tctctaagcg 3071401 tgcccgagaa taagaaaacg tcctgctgca cgacgccaat ctgcccgcgc aacgaagaaa 3071461 gcgtcatgtc ttttatactg atgccgtcaa tcgtaatgtc gccctccgat gcttcataaa 3071521 aacgcggaag cagactgcaa agcgttgatt tcccagcacc tgacggaccg acgaacgcca 3071581 ccgtttcccc cgcttgaatg gataggttga tgtcattgag gacattgtga tggtcatcat 3071641 agccaaacga aacatgttta tagcggatat tgcccttcag gccggaaaca tctttcgaat 3071701 caggtgagtc ctgaatatcc ggctctgtct ccatgagctc catatagctt ttgaaacccg 3071761 cgatccccct cggatacatt tcgataatgg cattaatttt gtcaataggc ctgaacagca 3071821 cattcgtcaa gagtacaaac gccacaaatt ccccgtacga taaggagccg cgaatgacaa 3071881 accacgtccc gcacaaaagg acaaacagcg tgacaaaccg ggtcagcata tagctgattg 3071941 aaccgttttt cgccatgatt ttgtaggaag aaagctttgt gacacgaaaa cgctggttgt 3072001 tgacggcgaa gcgttctttt tcaaatgctt catttccgaa cgcctgcaca agccggatgc 3072061 cgccgatgtt attttctaca cgcgcgctga agtctccgat atccttgttc agcgtggtaa 3072121 atgctttggt catttttttg ttgaaataaa gcgctagcca aatgacgatc ggcataatga 3072181 taaacgttaa taaagcaagc tgccagttaa taaacagcat cactccgaac gccccgagaa 3072241 tggtcatgac cgcaatgaat aagtcttccg gtccgtgatg ggcgacttca ccgatataca 3072301 ttaaatcgtt cgtgagcttc gacatcagcg ttcccgtctt gttgttgtcg taaaatttga 3072361 acgagagctt ttgcaaatgg tcaaaaagcg actttctcat atcagtctca atattgatac 3072421 caagcatgtg tccccagtag gtcacgatat actgaagagc cgagctgagc gcgtacaccg 3072481 caaataaccc gattgaggtc gcgatgatca gtccccagtc cctgcccggc agcaaggtat 3072541 caataaaata attgacgatc aaaggaaaac tcagctccat taaacctccc gcgatcgctg 3072601 agaaaaagtc gagaaagaac aacgttttat atggtttata atatgaaaaa aattgccgca 3072661 gcaccctatc ttcccccaat gtataaataa ctgataatat ttctcaatta tactatacac 3072721 gggctgtttt gtaagatcag atttcttttt tcttacagaa cacctgaaaa caggcgggca 3072781 aacgactctt ttgtccggtc agccacacct cttttataaa agccgacagg gctgagcttt 3072841 tcactttcct gcatatcctc ttcaaaatgg gcctcaaggg ttcggatcgc ttcggcatcc 3072901 gtgaagaaca cattcacttc aaagttgagc tgaaagctgc gcatgtccat attcgcggta 3072961 ccgacggagg cgagatcgcc atcaatgatc atgacttttt gatgcatgaa gcctttttgg 3073021 taggagtaca cttcaatgcc ctcaaggagc agctccggga aataggacct cgacgcgtat 3073081 tgggtcaaaa agctgtcgtt cttctccggc accataaccc ttacctctac cccctttgtc 3073141 gccgctgctt ttagcgccgt gcgaatggat tcattgggga caaaataggg cgtggcgatc 3073201 catattgatt tctgcgctga agaaatcatt tcataataaa ggtcgctcat gctttccttc 3073261 atgtcagggc ctgtcgcgac aatttgataa atgcctcctc cttccacggg aaccggggta 3073321 ttgtactcct cttgatcaat tagcacttca ttggagacat attcccaatc cagcataaag 3073381 atagcgtgga gcgtttgcac aatttccccc tcaagccgca ggtgtgtatc tctccaaaat 3073441 ccgatgtacg gatctctgct gatatattcc ttcccgacat ttaatccacc cacaaaaccg 3073501 gttttcccat cgatgatcac gattttccgg tgatttctga aattcagctt ctggttgaaa 3073561 aacccgtatt tcagcggaga aaacgggacg atgtccaccc ccgcttgttt cattctcata 3073621 atatctcttc ttgccagctt catgcttcct gccgcatcgt ataaaaacct cacctcgaca 3073681 ccctggcgcg ctttctccat cataatatcc atcatgccgc gtccgagcat gtctgattta 3073741 aacatgtagt attcaatatg tatgtaagat tccgcttttc tcattgcttt gaaaatgtcc 3073801 gggaaggttt cttcgccgtt tttcagcact ttgatgttgc ttttcgtatt gatattcata 3073861 tgggcagccc tgatggaata tgtaaagaac ctctcttgat tgtccttcag ccctgtcact 3073921 tcgggcgttt cctccttgtc aaacagcttc ctgagctttt ccctgttgta cattcgtttt 3073981 gtcttaaaca gctttccctt tacataaagc tgtcccgaaa acagataaaa cacgtagccg 3074041 acgattggaa aaaagacaag aatatggatc catagcagcg tgtgctgcga ggtgcggttt 3074101 tcaagaatta atgaatagat gctgaacaaa ataatgctta tatagcaaag caatcctccg 3074161 taaaactcaa gtctggaaac cggaaaaaac caaatgacat atgccccgat gagcatcata 3074221 tataaaaaga aaaattccag tctccttttc agcatcctga ttctctccaa tctgattcaa 3074281 ttacctctgt attacctctt ttttctaatc gataaacctt gtaagtaaaa aacctctccg 3074341 ccaaaggagg agaggtttag agaaaactaa ctgtcacgga attcatccgc atcgtttctg 3074401 cagaaataaa gcaagactat tggcaacgcc gagtgacaac atgagcggca agctgaaccc 3074461 gctcagcact ccggcaagcg ccgaaaagaa ggcggcgctg tgactgcaaa tacggtggat 3074521 agagtaaatt tgatacccat tctgatgaga gaaaatatat aaaacgggaa attgatcaga 3074581 aagatataag gagttagtca ggctgaatca taatctggct gttccgccgg tttaaaatga 3074641 gtaaaatcct tgatgttatt tccatataca aacataacag gattcccggc agcccagcca 3074701 ttaccttggc agaaaaaacc ccctcttgca agggggattt tcacgagcgt ttccgatata 3074761 caacgtagct gcgggtcaga tacttgagcg gcagactgaa cacatgaacc aatctcgtaa 3074821 acggccacag gataaaaacg acgtatccta tcacaatatg aaacttaaac catagcggga 3074881 cactctccat caaagaggcg tcaggcctga acaaaacgat ttccctgaac cagggcccga 3074941 ctgtggtccg gtaatcaaat cctttcgaat caatgttgag aaacgtggcc gcaacgcctg 3075001 acagcatcat gaacagcagc aggaggagcg taaggatatc ggatggcgag ctcgttttgc 3075061 ggattctttt gtcaaacagc cttctgtacg tcaggatgac aagtccggta catgccgcaa 3075121 tgcccgccgg caagccagcg ccaatcgcca ttttgtgata catatgctct gaaatgccaa 3075181 gggaagcata cacgccttct gggatcagaa tccccatgac atgcccgccg acaacgcaca 3075241 gcagtcccca gtgaaaaagt gtgctgccag ccgcaagttt tttcttttct aacagctcgc 3075301 ttgatttcgc cgtccagcca aattggtcat gctgatagcg gtaaatatgg ccgccgataa 3075361 agattgtcaa tacaatgtat ggcataatac cccagaggat ctgcccgctc atgcctgaac 3075421 agccccttca acgctttcac gtacgccaat gttttcaagc gcggccagca gcacgtgcag 3075481 cagttcagcg tatatactgt catttttttc gagacgggat gccagctccc tcacattgga 3075541 cagatatttc tcaaacacgc ttctcgctgc ttcaatttct gcagccgcag caaattccag 3075601 catcagcggc agataatcag gcagctcttt ctctgtcggc aggaaaccgg attgctcgta 3075661 tgtgtttttt aaatgcagca attcaatgcc gcgttccctt tgctcgcctg agttaaagta 3075721 ggtgacatac atatttgttt ttttcccgaa gtcgaatgta tagacatagt gttcaatcag 3075781 cgcttccgga gaatagctgg ctgacgtctc gaaaaagtgc agcagcttct cccggatttg 3075841 ccggttgccg atttcttgga taagagcctt ccaatcggga agctcggctc tccactcttc 3075901 atccggataa gagagaagac aggaaagagc agagaacgtg atttgccggt ctgtggtgtt 3075961 catcttgtta cacctcattt atcaaaagtt agaaacagga gccggggccg cctgaaaatg 3076021 ataagccgca gcttccttgt tcagcgtata aatctgatac ttcttctcga tggctgctcg 3076081 gaatcacaaa gcggtcatca tatttggcaa tcgcaagcag ccgatacata tcttcaattt 3076141 gctgttctgt taagccgaca ctggagatca gttccggatc gattgattta ttcgtctgga 3076201 ccgctctcat atactggcgc atgacagaca ttttctttaa tgttgaccga atatgatccg 3076261 tatcaccggc tgttaacagc tgcgccaaat aatctatcgg gattctcatt tggtcgatag 3076321 ccggaaaaat atcttccgcc gtttgccggc tgccttttcc ttcaaagaga ttcataatcg 3076381 ggctgagcgg cggaatgtac cacaccattg gcagcgtgcg gtactcagga tgaagcggca 3076441 gcgcgatctt ccagtcaatg atcattttat agatcggtga ttgctgcgcg gcctctatcc 3076501 attcagccgg aatgccttgt tcttttgcca gtttggcaac ctcaggatca ttcggatcaa 3076561 gaaaaacgtc caattgggaa tggtagagat ccttttcatt ttcaacagat gccgcttcct 3076621 ccactttgtc cgcgtcatat agcatgacgc cgaggtagcg gattctgcca acacacgtct 3076681 cagagcagat ggttggcagt cccgcctcca aacgcggaaa gcagagtgtg catttttccg 3076741 ctttgttcgt ttgccagtta aaatagactt ttttataagg acaggatgag acgcaatatc 3076801 tccatgaacg gcatgcgttt tgatccacaa gcacaatgcc gtcctcctcg cgtttgtaca 3076861 tggcgccgga tggacaggat gagacgcatg ccgggttgat gcagtgctcg caaatacggg 3076921 gcaaatacat cataaagacg tcatcgaatt ctgttttgat cgattcctcc atcttttgta 3076981 cgttgggatc ttcaagtccc gtaatgtggc cgcctgcgag atcgtcctcc cagttcggtc 3077041 cccattcgat attcatgaaa tcccccgtca aggacgattt cgggcgtgct accggctggt 3077101 gttttttctg cgggctgttc gttaatgttt cataatcata gttccaaggt tcatagtaat 3077161 catcaattga cggctgattc ggattataga aaaggcctgc aagccgattg gttttcgagc 3077221 ccgatttcag ctcgagcttt ccttttttca atgtccagcc gcctttatat ttgtcctggt 3077281 cctcccattg cttcgggtag ccgatgcccg gctttgtttc tacattattg aagtacatat 3077341 attccgcacc ggaacggttt gtccacgtgt ttttgcaggt gacgctgcac gtgtggcagc 3077401 cgatgcattt atccaagttc atgaccatac cgatttgcgc tttaatcttc aagccaatcg 3077461 acctccttca gcttgcggat gacgacgttc aggtcgcgct gattccccgt tggaccgtaa 3077521 taattaaagc cgtagctgag ctgggcgtag ccaccgatca tctgtgtcgg cttgacgtga 3077581 atccttgtcg ggctgttatg ggtgcctccg cggttattcg tcagctttgt gccgggcacg 3077641 ttgatgtggc ggtcctgggc atggtgcata aacgccattc ctttaggaat ccgatgagac 3077701 aaaacggctc tcgcgacgac aacgccgttt cggttgaagc attcaatcca atcgttgtct 3077761 ttgatatccg tgtcctctgc atcatcttta ttcatccaca cggtcggccc gccgcggaac 3077821 agcgtcagca tcggcagaga atcaaaatac atgctgtgga cagaccattt attatgcggc 3077881 gtcaaataat tgaggacgat ttcttttccc tcttgatcag gccgtttgct cagaaacggg 3077941 cgatgctgga ggatcggttt gaatgtcgcc atcgtttcac cgaattccat catcagttca 3078001 tgatcgacat aataggattg tctgcctgtc agcgtccgcc acggaattaa tttttcaaca 3078061 ttcgttgtaa acggcgaata cctgcgccct cctttttcag agccggtaaa cgctggagac 3078121 gtgatcaccg ttttcggctg ggctgtaatt tgttcgaacg taaagcattc ttcctcgcgt 3078181 tcttccgcca ggtctttcag cttcaggttc gtgatgtttt caagtgattc ccatgctttt 3078241 actgcgacct ttccattcga agtggatgat agggttaaaa tcgcttctgc agcctgcttt 3078301 gcttcactta tatttggaca tccctttgcc acgctgtccg aggtgatttc tcccagtctc 3078361 tgtttgagtg attcatattc atcggctatt gaccagctca tcccttttgt tccgctcggc 3078421 tttaaagcaa cgttcggacc aagtgcagtc attttatgaa aaatgtgttt gtaatcccgt 3078481 tcaacgactt ggatgttcgg catcgttttt cccggaatgg cttcacattc gcctttgctc 3078541 cagtcattga ttttgccgaa tggctgggcc aattcctgca tggtgtcgtg gagcagcggt 3078601 gtcgcaacca cttctttcac cggctccata tcgacttctt ctgccagatc ggaaacggct 3078661 tttgacagcg ccttgaaaat atcccagtct gacttcgatt cccacggagc cgagatcgca 3078721 ggagcaaatg gatgaatgaa cggatgcata tctgtgctgc tgagatcgtg tttttcatac 3078781 catgtcgccg ccggcagcac gatatcggaa tacagcgccg tacccgccat tcgaaaatca 3078841 agattgatta ataagtcgag ctttccttcc ggcgcctgct cccgccattt gatttcttct 3078901 gggcggatgc tgtcgctgtc gtcattcatt aaaccgttcg ttgtccccag caaatgcttg 3078961 agaaaatatt catgcccttt tcctgagctt gagatcagat ttgcccgcca tacaaagaga 3079021 ttccttggga aattcacttc attgtcagga tcttcaatcg cgaatttcag ttttttctct 3079081 tggagctgtg aggccacgta cgcacctacg tcttcaggtg ttgctgcccc tgctttttca 3079141 gcttctttat acagatcgat gccattttga ttgaaagtcg ggtaagacgg aagccaccct 3079201 agccgcgccg ccagcacatt gtaatcagcg tggtgcttgt agcgggatga agcagcaatc 3079261 ggtgatgcca aatcactgat cggctggtcc tcataacgcc actgatctgt cgcaaagtag 3079321 aaaaatgagg tgccattttg cagcttgggc acgccttccc agtcctttgc agttgcaatc 3079381 gtctgccacc cttcagcagg tcggagcttt tcctgcccca cgtaatgggc ccagcctccg 3079441 ccgtttacgc cttgggcgcc tacaagtaaa acaagattta acactgctcg gtagatcgtg 3079501 tcggagttga accagtggtt aatgccggcc cctacgataa tcatggaccg gccgtctgta 3079561 tcgatcgcat tttgggcaaa ctctctggca atcttaacga cagcttcttt tttgattcct 3079621 gtcatttgtt cctgccaggc aggcgtaaac ggctcagggt catcatagga gacagccgat 3079681 cgttcgccga tgccccggtt cacgccgtag ttagccagta tcaagtcaaa cacggtcgtg 3079741 atgtacgttt cttcaccgtt caggttcatt tttttaatag gaagatcccg ctcgagcact 3079801 ttgtttccgt catttgaaaa atacgggatg cgcaccgtgc cgatttcgtc ctctattccc 3079861 agcacagaga gacggggttc aatcggttcc ccggtttctt catcaatcat gtgcaggttc 3079921 catttctgct gcccgtccca gcgcgagccc attgtccctt ggggtatggc aaatgaactt 3079981 gtctgttcat cccaaaccgc aggcttccac tgatcatgct ttgtcttccg cccgatgtcc 3080041 ttcgcatgca gaaaccgtcc cgctgtgtat acgccatttt cttttgacag agtgacgaga 3080101 aatggaaaat cagtgtattg cttcgcgtac tcaataaaac gttcagtttc ttggttcacg 3080161 taaaattcct gcagaataac gtgacccatc gccatcgcaa gcgccccgtc agtcccttgg 3080221 cgaatactca gccagtcatc cgcgaacttt gaggattccg caaaatctgg actgatcgaa 3080281 atgaccttag cgcctttata gcgggcctcc gccaaaaaat gcgcgtcagg cgttctcgtt 3080341 aacggaacgt tggagcccca tgtgataata tagccggaat tgtaccaatc actgctttcc 3080401 ggaacgtccg tctggtcacc ccaaatttgc ggggatgctg gaggaagatc cgcataccag 3080461 tcataaaaac tgagcatagg gcctccgatt aacgacataa accgggagcc tgatgcgtgg 3080521 ctgatcatgg acatggccgg aatcggagaa aaaccgacgt ttcggtcagg cccgtatttc 3080581 atcactgtat acagcagaga ggctgaaatc agcttcagca cctccggcca ttcagcgcgc 3080641 acaaaaccgc ctttccctct cgcctgttta taggacttcg ctttttcagg gttttcgacg 3080701 atcgatttcc aggcttccaa tggattttga tgcgtctgca atgcctcccg ccacaaattg 3080761 atcagcacac cgcgcacgta tggatatttc acacggagcg ggctgtagat ataccatgaa 3080821 aaactggccc cccgcgggca gcctctcggt tcaaaatcag gcatatccgg gcctgttgat 3080881 ggataattca aattttgccc ttcccacgtg actattccgt ttttcacata aatattccag 3080941 ctgcaagacc ctgtacagtt gacgccgtgg gtggagcgaa cgactttgtc gtactgccat 3081001 ctgtttctgt atacattctc ccaatcgcga tcctcgcggg tagtttggct atgtttattt 3081061 gaatggtgtt cgataggaga gaaataattc aatctcctaa acaacggact ccttttcttt 3081121 ttcttcatga gagttcactc cttccgagtc aggtgatgct aagttcacta taaacagaga 3081181 cagcgtgttt ccttgtgaac tatgtcacac actctgcttt tttcacaaaa tgttcacaca 3081241 aaggagaagg aaggctgcgt tcaggcagga cgcttgggtc attagctgcc tttcattcaa 3081301 agatcaaaaa aaaccggctc tatttaagaa ccgggctcag cgttttcatc ctgtgatgta 3081361 tgcagatacc gcaaaaataa ttgataggaa caaaaaacat tttgctgaag catagccaaa 3081421 aagttcattt gcagctgcgg atgataagac atcattttct taaatatgta atatgggatg 3081481 ttgagaatca gaatgtctga agtggcattg actgagataa agggcgataa ataaagcccg 3081541 cctttttcat caatcggaaa cacatcgcct ttttcccaca gcgcaacggt tttcgaccct 3081601 tcagggagcc ttgtgtccat aaaacggaca ctgcctttta atacaatata aacagattga 3081661 gaatgaagaa aagatggaga ctgatcacat gaaccgcgga taaacgtgcc gtttttcagc 3081721 aaggtttcga caatggatag aggcacttca ttaaacatag gaagttgttt cagaaataat 3081781 aaatagtcac actgattcat aggaaaacct cctgtgctaa ggatagcttt agtgtagctc 3081841 gactgagcct gtacagcagt gatgtatttc acagcctgta tgatgaatgt cacttatcag 3081901 gagggtgaat gcatttataa tgaaagaaaa aaggaggatt tcgatgaagg cgctgattcc 3081961 gaagcagcac ggggcgtggg cgatgctgct gatcccattt ttactcggca tggtcaaggg 3082021 aggccccgtt atttggcata ttccgctctt ccttggttgg cttttcctat acttagcggt 3082081 ttatcccgtt acgcttgcct taaaaaagaa acaaagcaaa ccatatcaaa agtggatgtg 3082141 ttattacggt tttcccacct gctgcttttt gatgatctcg gtctttcata agccgcctct 3082201 catctgggtg ggcgtttctt tactgccgct gtttctcata catatgtatt ttgcccgcag 3082261 aaaaaacgaa cgagccttat tgaatgatgt tgcaggtgtc ttgttctttt gttcgggcgg 3082321 gtttgcgagc tgctggctgg ggatgggaac ccttgacggc tgggcttggt ttattttctt 3082381 gcagtctgct ttatttttta tcgggagttc cttttatgtg aaatcggtga tccgcgagag 3082441 aaaaaacagg gcatttgcat actggtcatg gggatatcac ctgctgctcc cctttttatc 3082501 cgctcttttc ggagcaggat gggcgtttct cgcttttatc ccgagcagct tgcgggcatg 3082561 gttttttcat ggaagggatt ggcccgtaaa aacgattggc attctggaaa tcgtgaatgc 3082621 ctgcttcttt cttgccgtca tgtgcctgtt tatcacaagg taaaaaaaca aggacaccgc 3082681 tgtccttgtt tttttcagtc aatattgcaa atctccagcg ggcaattttc acactcaatc 3082741 tcacatcgta aatagtcccg cttgtgcaaa ataatttttc cggattcgtc tatcgaaata 3082801 accccttttt tgcggagatc tccgagcata cgattgacgc tttcccgtgc agccgcgcaa 3082861 aactttgcca aatcctgatt tgtcaggaca atgttaatca gaatgccgtc gcttcgctcc 3082921 actccgtagc tgtttgataa gcggataagg gtagaataga gcgccccctt tttgccatga 3082981 agaagcagat ccctgatttt ggactgaatc ttccggaggt gcgtgctcat ccatttcatg 3083041 aactcaaatg tcaaagcgcc gttttggatt aattcttttt ccagcttatt tttattaatg 3083101 acgagcacct cgccatcctc tagtactttt gcactgagca tataccttgg ttcttcagtg 3083161 aaaagtgtta attctccgac gatatcatgc ttttggcaga ttctaagcgt caggtctttt 3083221 ccgtcagatg tcagcttgcc gatttcaatg agtcctgatt gaatcagata aagctcttct 3083281 gcatccattc cttcccgaaa caaatacgtg tgtttttcca tttttctttt cgtgctgatc 3083341 gattccagca attcatacag atcgctggat ataagatcac tatcagatgg tcgaacagag 3083401 agaaaattca tgagctcacc tcgaagaaag tcacgttgtg tgtttattgt aacgtgaatt 3083461 gatttgtacc catcgagaaa aaactaacaa tcttgtgaat gccccagtgt tagttgatgc 3083521 tctggctgtt tctctccgtg tgtgttttca ttctttcctg ccaatacatc catatgacaa 3083581 ggacaaaact ggctaacgcc acctctgaaa gcgccataaa cccgatcgcg tactggcctg 3083641 ttgcctgaaa tacactcgcc aatatgagcg gaggaaaaaa gccgcctaaa ccgcccatgg 3083701 cagacacaat cccattggca atccccgctt gcttcgaaaa atagaaaggc accagtttaa 3083761 aaacagttcc gtttcctatg cctgagcaga cggccacggt taatgatcca aacgtataaa 3083821 ggccgattgt cggcgagaac gataggataa tgcctgataa tgtaagcccg gcaaaaacaa 3083881 acatcaagat gcggagcggg ctcattttat cagccaggaa tccgcccgca ggcctgagca 3083941 gcgtagaaac cgcaataaag ccagccgtcc gcaagccggc atctgcagga ttcagcccaa 3084001 aatgctccac cagaaagttc ggcagataga tagtgaaggc gacaaaggca ccgaacgtaa 3084061 taaaataaaa caggctcaga aaccatagca catgatttcg gtaaacagct ttgatttgag 3084121 tcttaacaga aactttgacc ttcttctcat gcctgtcgcc aaacaatacg tgcagtaagg 3084181 caaagacagc cagcaaaatc agatacattt gcacggttga tttccacccg acggcttgag 3084241 cgataaccgg cgctgcaaat gtcgtaacgg ctgtcccgat atttcctgca ccgtaaatcc 3084301 cattgacgac accgtgcttt tctttcggat aatatttcgg gagggaggtc accccaatgg 3084361 aaaacaccgc tcccccgatc cctaagaaaa agccgcctgc gattaaatca aacagagaat 3084421 ccgcgatact gatccaaaat acaggaaata aaagcaggat gaagctgacc ataaacatga 3084481 gccgcgcgcc aaacctgttc gttaaatacc ctaaaggaat gcggagaagc gacccgagga 3084541 tcacaggaat cgcggtcact aaagaaatct cacccttgct taaatgaata tctaatgtga 3084601 tttgggaaat gagtgatgaa atcagcaccc aaaccataaa ccctgccacc aagcttaatg 3084661 actgtaacga taattgaatg tgttgacggt tgatcatttg gcttgcccct ttcaatgatt 3084721 caataatcag tcttatcata caaaaactag ccaaacagga ttgtgaatta catcacacgt 3084781 ttttctcata aaaaaaggac aaagcccgaa gactttgtcc ttttgatcgt gattacattt 3084841 tttccggagc cgatacgccg atcagctgaa gcgcattgtt cagcgtaatt tgcgttgcct 3084901 tcattaaagc caggcgcgcg cggcttttct cttcattttc agggtcgatg actttctctg 3084961 cgttgtagaa gctgtgcaga gcagaagcca gatcataaat atagttagtg acacggtgcg 3085021 gaattcgttt ttccgctgct tccgccactg cctctgggaa gccgccgatc gttttcagca 3085081 gatcgtattc tttttctgat tgaatatggc tgaaatcaag atctgccgcc ggtttaagcc 3085141 cctgctcttc cccttggcga agcatgctgc aaatacgggc atgcgcgtat tgtgcataat 3085201 acacagggtt ttcgttagat gttgatacag caagatctaa gtcaaaatcc atatgggtgt 3085261 ctgcacttcg cattgcaaag aagtaacgca cggcatccaa gccgacttct tcaatcaggt 3085321 cacgcatcgt tacggcttta ccggtccgtt tgctcatttt cattttctcg ccgtttttgt 3085381 aaaggtgaac gagctgaatg atttctactt caagcgttcc tttttcatag cccagcgctt 3085441 cgattgccgc tttcatacgc gggatgtagc cgtggtgatc ggcgccccaa acgttgatca 3085501 gcttatcaaa gccgcggtca agcttgtcct tatgatacgc gatatcagga agaaggtacg 3085561 tgtacgtgcc gtccttcttg atcaatacgc ggtctttatc atcgccgaaa gtcgtggaac 3085621 ggaaccaagt cgcgccgtct tcttcataga cgtggccttt ttcgcggagc gcttcaagcg 3085681 ccttgtcgat ttttccattt tggtacagtg aagtttctga ataccacaca tcaaacggca 3085741 cacggaagtt ttccaagtcc ttgcgaagct tttccagctc gtatttcagg ccgtattcac 3085801 ggaaaaacgc gaggcgttca ctttcctctt cgttaacgaa acgatcaccg tattcctcag 3085861 cgagacgctt tccgatcgca atgatatcct caccgcggta gccatcctcc ggcatcggtt 3085921 tttccaatcc gagtgcttca aagtaacgga cttcaacaga aagcgccaga ttgttgattt 3085981 ggtttcccgc atcgttaatg tagtattcgc ggcttacatc gtaacccgct tttgaaagca 3086041 cgttgcacaa ggaatcgccg acagccgccc cgcgcgcatg cccgaggtga aggtctcccg 3086101 tcggattcgc tgatacgaat tctacctgaa ctcgttcacc gtttccgatg ttcgtttccc 3086161 cgtatgcttc ccctgcttcc agtacagacg gaatcagctt tgttaaatat tgattgttca 3086221 tatagaaatt gataaaaccc gggccggcga tatccagttt ttcaatcgaa gccttccctt 3086281 tatcaaaatg ggcgacaatc tcttcagcga tttgacgcgg cgcttttttt gccactcttg 3086341 ccaactgcat cgccatattc gttgagtagt cgccgtgtgt tttatctttc ggtgtttcta 3086401 aaacaacatt gggaatctgg ctttcttcag ccagtcccgc tttcagaacg gccgctttga 3086461 tttcttcttt cagcacgtcc ttcatttgtt ccgcaatgtt catgcgtgag ttcctccctc 3086521 atacgtgatc gtcatattat gtaaatgctc ctgctcgtct ccgacatgca tgtcatatgc 3086581 gatgctgata cggccttttt cttcatcgag atcagattga atcgattttg tgcttgtttt 3086641 cagctcaagc tcaccaaatg acattttata tttagcaatt gtggaagctc ccgttacgaa 3086701 acgctgattc attttgacag cgcctgacct catgaccagg acttcgcctt cgcttacttt 3086761 cacaatcgtt ttgactttgc ctaagtcgtg ttcttcataa taagatagat acactttatt 3086821 ttgttttaca tagtaaaatc cggtggtgcg gaattcgatg acttcttggt ttccgtcatc 3086881 ctcgatcaca gacttcacat ggagtgttat cggtgtctct tgcttcattc tgacacgtcc 3086941 ttttcatcat tccactttga cttgaatagt ataatcattc ggtttgtaaa cttcaactgc 3087001 ttctatctta ccatcattgc tcatcagatt tgaagataaa cctcataaaa agcatttcct 3087061 tatatagaag agaaaatcat atcactaatt acctttagga aatgttacga gctcgctaca 3087121 tcgcaatcgc agacggaccc gcgccaaccg gaatcaccgt cacggctgta taatcacttg 3087181 tgcggtacac ggtcacagca ttgtcgttgg gctgtgccgc ataaatatac tgtttgtccg 3087241 gcgttacggc gaggtcaaag gcgccgggga gagacacgtt tgcaatgatc ctctgtctgg 3087301 ccgtattaac tacgtataag ttattaatga gaaacggttc actatatggc tctagaaaat 3087361 aagctctagt actatcgaga gaaaatacaa tcgtcctcag cgtttcaaat aaacggctga 3087421 agtcccctcc cctgcttaat ggtgacaaac taatctccgt tacacctttc ggccacagct 3087481 caccattcaa tacgtacgca aaatttccag cgtaaggagt tgtaattaaa ctgggaaatt 3087541 caaatgtatc tatgatactt tctaccaact gcccagtatt tacatcatat ttatcaaccg 3087601 accaactgct tccattagcg gtatagacat actgtccatt cggatcaaga gcaaagtcta 3087661 aagcgccggg tatcggaatg acatcaatga ccgattgaga ggccgtgtta atcacatata 3087721 tagatccggc ggccatcacg tatgcgaact catctgttgg atcaaattcg atttttctcg 3087781 gccctcctcc aacagtaatg gtatttatga tggttaatgt tttattatca atcactgaga 3087841 caaggttggt atttccatgg aggacatacg tgaatgcttt atcgaaagta acgcctagat 3087901 tagttggcac gtcagaaaaa gggattgttt ttacaacagt gtttaaatct gcatcaataa 3087961 ccgaaaccgt gctgtctcca gtattggcag taaacacata cgattgaggg tctggtgatg 3088021 gcggtaaaac aagtgtcccg gccaccgtaa gcggactgcc gtagaaaggc ggtacaatga 3088081 gcagatcttc cactgttatt tgactgaaat caggacagcg gccagactgt gctgcataat 3088141 aaacaacttg atcaatctct tcagtatgaa tcacagaaac agccccgtct ccttgtccat 3088201 attgatttcg tacaggcgac acactgacaa gaagcgtaat ggtcccttgt actctcacag 3088261 catatcgaac accgatatct tctggttccg gcccagtctg gattaagcaa ggctcactga 3088321 tacaggacaa attgtctgta ctccatgtaa cagccgctga cgcttcggcc gtatcaacct 3088381 tgaagccctc agggaaatct atcggcactt gaaacggcgc ttcccggcta atttcctcat 3088441 cacaaaaaca gaaacaattt tcctgtaaag cagaaagatc attctttttc atgatttcac 3088501 gtccttttag aaatgcacaa catgcagcgg ttaaatcgta atggcacccg gtgaaacccc 3088561 aagagatatc acagtttcct cagaataatc atctgtgttg taaacaatga tgctctgctc 3088621 tataaaacga gttgcataca gaaaatcgcc attcggggta aacgcatagt ctgttgctga 3088681 ttgcggaaca tttcctataa cgcctgctcc atttggactg acagaatata aattgccagt 3088741 gaagccgtca tataaataca cctctgctcc actcgtaaac attcgatatt ccccttcata 3088801 ctccagctct tgggtgctgc tgatggtaaa cgtatttaaa tcaataaccg tcaaataatt 3088861 aaaaaagaat tcttgttcta atacataggc ataccgctcc ggccaatttg tttctatggt 3088921 tgatacgata agctctcgtt caattgttcc tgtgacttca ccggtagtta ggtccacttt 3088981 ttgcactatt ccaaaattca gaacataggc gaataaccca ttgggatcga ttgcaacatc 3089041 atatccttcc acaggaatcg acctatccac agttaacgta tcaattccaa tcacataaac 3089101 cgcagtaccg gtgaaaacat aagcaaactc atgattaggg ataaatctaa tcaatcgagg 3089161 cggctgatcc agcaatatag ttgctgtcac tgttaatgtg tcataatcga tgacagaaat 3089221 cacattattg ttgggatgta agacaaacac agcgctttta tctggcgtaa tttcaatacc 3089281 tgccggattg tacggaagag caatcgttgt cacaacagta tcggtgtttg tatcaatcac 3089341 agaaactgat tgatcatttg gattcgctgt aaacgcgtag acgggttccg gctccggtac 3089401 aagcacaatt gtccccgtca ccgataaagg actgccgtaa aacggcggaa caacaacaag 3089461 gttctcaatc gtgatgtcac tgatatccgg gcaatcatcc gattcatcgg aataatagac 3089521 gacttgatcg atttctgcat tgtgaatgac ggaaacagcc ccgtcccctt gtccatattg 3089581 atttcggaca ggtgagacac tgacgagtag cgtaacggtt ccctgcaggc gcactgcaaa 3089641 ttgaacaccg acctcatcag gctcaggccc cgtttgaatt aagcaacggt cactgacaca 3089701 agaaaggctg tctgcattcc acgtcacgtt tgcaacagct tcagccggat caacgacaaa 3089761 cccttcaggt aattcaatcg gtgcttgaaa catggcttct cggcttgctt ctccctcaca 3089821 aaaacataag cactcttctt gttctgctcc tgctttttct ttaaaggaaa gcttgttttt 3089881 tctcattcct tcacttcctt ttcagacata cactgctcac gcagatataa cagaatatgg 3089941 aagggtaacg tgtttgcttg tacaaattgc tgagggtaaa cgcttctttt tgaaaatata 3090001 tctccaaaca tgcggtgtaa cgaaagaaaa aattgcggtt tttttgcgct tctcacaaga 3090061 atgttgatga taaaatatga catatataga attatgaagg gagggatttg caaacgtgac 3090121 aggtgtcata tcttcttctt ccatcggaga aaagattaac gaatggtata tgtacatacg 3090181 ccgattcagc atacccgatg cagaatattt gcgacgagaa atcaagcaag agctggatca 3090241 aatggaagaa gatcaagacc ttcatttgta ctattcactg atggagtttc ggcacaacct 3090301 aatgcttgag taccttgaac cgttagaaaa aatgaggatt gaggaacagc cgagactgtc 3090361 tgatctgctg cttgagattg ataaaaaaca ggctcgttta actggtctgc ttgagtacta 3090421 ttttaacttc ttcagaggca tgtacgagct ggaccagcgg gaatatctgt cggctattaa 3090481 atttttcaaa aaggccgaaa gcaagctgat attcgttaag gatcggatag agaaagctga 3090541 gtttttcttt aagatgtctg aatcttatta ctatatgaaa caaacgtatt tttcaatgga 3090601 ctatgcacgg caagcatatg aaatatacaa agaacatgaa gcttataata taagattgct 3090661 gcagtgtcat tctttatttg ccaccaattt tttagattta aaacagtatg aggatgccat 3090721 ctcacatttt caaaaagctt attctatggc agaagctgaa aagcagcccc aattaatggg 3090781 gagaactttg tacaatatcg ggctttgtaa aaacagccaa agccaatatg aggatgccat 3090841 accttatttc aaaagagcaa tagctgtttt tgaagaatca aatattcttc cttccttacc 3090901 tcaagcgtat tttttaatta cacagatcca ttataaatta ggaaaaatag ataaagctca 3090961 tgaatatcat agtaagggaa tggcttattc acaaaaggcc ggagatgtaa tatatttatc 3091021 agagtttgaa tttttgaaat ctttatactt atcaggcccg gatgaagaag caattcaagg 3091081 attttttgat tttctcgaaa gtaaaatgtt gtatgctgat cttgaagatt tcgctattga 3091141 tgtggcaaaa tattatcatg aacgtaaaaa ttttcaaaaa gcttctgctt attttttgaa 3091201 ggtggaacaa gtaaggcaac ttattcaagg aggagtgagt ttgtatgaaa ttgaagtcta 3091261 aactattact ctcttgtctg gctctaagca ctgtgttcgt ggcaacaact attgcaaatg 3091321 cacctacaca ccaaattgaa gttgcacaac gaggaatgat ttaaccgccg tccatcggcg 3091381 gttttttcgt cccctcttta ccaaagtctc ccaatccatg ctatgatctt ttcaataatc 3091441 ttgaagagag tggaaatgca gcatgtctct aaaaagtgtg agaacccact ttactcaatg 3091501 gaatcgagaa aatgatgtga cggagttcga aacgtcgagt gcgacagttg aacaggcagc 3091561 tgagacaatc ggcgtaagcc tgtctagaat cgccaagtcc ctgtccttca gaggggaagg 3091621 agatcaggtg attctgattg tggcagccgg cgatgccaag atcgacaaca aaaagtccag 3091681 gcaaacattt ggctttaaag caagaatgct ctctcctaat gaggtgctgg agcagacagg 3091741 ccatgaaatt ggaggagttt gcccatttgg attggctcat gatcctgagg tttatcttga 3091801 tgtatcgctg aaacggtttc agactgtttt ccccgcatgc ggcagcagaa actccgctat 3091861 tgaattaaca ccgaaagaat tatccgaatt ttctttctca aaagtgtgga ttgatgtttg 3091921 taaagactgg gaataaaaaa acatccagac atcgtctgga tgtttactta tttcacaaac 3091981 ccaagcagca tttcacggat gattttgctg gctgtgtttg ccgtttgctc tgagtggtcg 3092041 tataccggcg cgacttccac taaatcagcg ccctttacgt ttacctctga acgcgcaatt 3092101 tcatggaccg atgcaagcag ttctttagac gtgatgccgc cggcgtcaac cgttcctgta 3092161 cccggtgcgt gtgcagggtc taatacgtca atgtcaattg tgacataaac cggacggccc 3092221 gccagcttcg gaagcacctc tttcagcggt tcaagcactt caaattttga gatgtgcatg 3092281 ccgttttcct tcgcccattc aaactcttct ttcatgccgg aacggattcc gaatgaatac 3092341 acattgtgcg gtccgatcaa ttctgccgcc ttacggatcg gcgtggagtg agaaagcggt 3092401 tctccctcat aatcaacacg aagatctgta tgtgcgtcaa aatggataat cgcaaggtct 3092461 gggtatttct tgtacatcgc tttaatgaca ggccatgaca cgaggtgctc cccgcccata 3092521 cccattggga acttcccttt ttctaaaatg ctgtccacgt actcttcaat catatccagg 3092581 cttcgctgcg gatttccgaa cggcagcgga atgtcgccag cgtcaaagaa gttcaagtca 3092641 gccagatcgc ggtctaaata tgggctgtat tcctcaaggc cgattgacac ctcacggatt 3092701 ctgcttggac caaagcgtga gcccgggcga tagctgactg tccagtccat cggcatgccg 3092761 taaagaatgg cgtccgcctc ttcccactcg ggacggctcg cgataaatac ttttcctgaa 3092821 taagcttcat caaatctcat ctataatacc ctcgctttcc tgtaaaaaag cgcaagattc 3092881 gctcctgcgc cataccttca ttatttaatc aggtcactca caaatttcgg cagaacaaac 3092941 gccgctttat gaatatcttt tgtgtaatat ttcgtctcaa tatcgaagaa acggctgtct 3093001 tccactgcaa gcggatcata ttttttcgag ccaattgtaa atgtccacaa accgcttgga 3093061 tatgtcggaa tgttcgccgt atacagcttc gtaatcggga agatttcctt cacgtcgcgc 3093121 tgtacatttg tgattaattc cggtgtaaac catgggttgt ccgtctgcgc aacgaaaata 3093181 ccgtcttctt tcagcgcttt tgcgattcct gcgtagaatc cttttgtaaa caggtttaca 3093241 gccggtccga ctggttcagt cgaatctacc atgatgacgt catattgatt ttcagatttt 3093301 gcaatgtgca taaatccgtc atctacctgc acgtcaacgc gcggatcatc cagtttgcct 3093361 gcgatagaag gaaggaactt tttagagtat tcgataacct tgccgtcaat atctacaagt 3093421 gtcgcttttt tcacgcttgg gtgcttcagg atttctctga taacgccgcc gtcaccgccg 3093481 ccgactacga gaacgtgctc cggatttggg tgcgtgaata atgggacatg cgccaccatt 3093541 tcgtgataaa cgaattcgtc tttttcagat gtcatcacca tgccgtccaa aaaaagcatg 3093601 ttgccgaact cttctgtttc caccatttct aaatgctgaa actccgtttg ttctgtatgt 3093661 aacgtcttgt taaccttcat cgtaatgcca aagtttttcg tctgcttctc tgtgtaccaa 3093721 agttcgctca attgtcatct ccctttcgag gctgtattca tttattgtaa gcgtcttatc 3093781 agcttttatt ctcggttgaa atctcatttt cacctaagga aaaagtatag aggatggcgg 3093841 ggaaaaagta aagatgcgtc ctgttctgcg atgtttaaaa acgatctttt tttctcataa 3093901 tagtagaaac ataaaaaaag ggggaacccg ttgtggatgc aatgacaaat aaacggctga 3093961 gactgacgct gaaaaccgtt cgcgccttta tctttttagg ggcttttgcg gccttggcgg 3094021 cagctgctgt gtttatgact gtcattttga tagccaaata ccagggcgct ccctcggtgc 3094081 aagtgccgca atccacgatt ttgtacgcga gtgacggctc aaagctcggg gaaacgaact 3094141 acggcgaaaa gcgctattgg gtccccttaa aggacatgaa tccgacgatc gtaaaagcga 3094201 cagtggcgat tgaagaccag aatttctacg atcatcacgg ctttgattat aaacgcatgg 3094261 ccggcgcggc gcttgctgac ctgaaagcat ttgccaaggt tcagggtgca agcaccatca 3094321 cccagcaata tgcgagaaac ttataccttg aacacgacaa aacgtggaaa cggaaatgga 3094381 atgaggcgtt ctacacgatc cgtctggaac aaaactattc taaggacgag atattagaag 3094441 gctatttaaa tacgatttac tacggccacg gcgcctacgg cattgaagca gcttcccgcc 3094501 tgtatttcgg caagcatgcc aaaaacctga cggatgcgga ggcggcgctt ttggcaggaa 3094561 tcccgaaagg cccttccggc tattcaccgt atgtcaatga gacgaaggcc aaggaacgcc 3094621 agaaaacgat tgtgcggatg atggaaaagc agcagatgat cagccaaaag aaagcggatg 3094681 aattgatcaa ggaacctctt tcctatcagc ctttgaataa acaagtttcc aagagaaagg 3094741 ctccttattt ctacgacaat gcgatgagag agctggaaaa aaagctcggc atgacacggg 3094801 agcaaattga aacgagcggg ttaaacgtct atacaacggt agataaacgg atgcagcgca 3094861 tcgccgagga gaccattacc gaaacggtta acgcgggctc tgacattcaa gtcgggtttt 3094921 cagccattga tccccgcacc ggaaacgttc tcgcccttgt cggcggcagg gattatcaaa 3094981 aaagcccgtt tgaccggacg acacaggcga agcgccagcc tgcttcgacg atcaagccgt 3095041 tgctgtacta taaagcgatt cagagcggat ttacgccagt cactttgatg aaaagcgaag 3095101 aaaccgagtt tcaaattgat gcaaagggag aaacctattc tccaagcaac tataacggat 3095161 actatgccaa caagccgatt acgcttctgc aggcgctggc gctttccgac aatatttacg 3095221 ctgtgaaaac gcatcttttt ctcggcacga acaaacttgt aaagacggca aaggaattcg 3095281 gcattaccgc ccatcttcaa gcactgccgt ccctggcact cggcaccgaa cccgtacgtc 3095341 cgattgagat ggtcaacgcc tatgccatgc tcgcaaatgg cggaaagaaa atcgaaccga 3095401 cttttatttc aagagtaacg gacgcagccg gccacgtgct gtacgaaaac ccgaatcagc 3095461 ataaacaggt gcttgatgaa aaagccgctt ttgtcacagc gagtatgatg acaggcatgt 3095521 ttgatatcga tttaaatgga tatacgtcgg ttacggggcg aacgatagcc aaccgcctga 3095581 caagaacgta tgccggaaaa tcaggaacca ccagcgcaga cagctggatg atcggcttca 3095641 atccgaagct ggccgccggt gtttggaccg gctatgacaa aaacagcacc atcgactcgg 3095701 tcgaagaaaa aagctatgct aaaaccattt gggcggactt catggaggac gcgctcaaag 3095761 gcgaaccgga aaccgcgttc aagccgccaa aaggcgtaac cggtgtgtac attgatccgg 3095821 aaacaggcta ctcatcaggt cccggctgcg ccgctaagca ttacacatat tttgtgaaag 3095881 ggacagaacc cgcaaacgtg tgctacgggg cagaacccgc aaaacaaaca aaagaccggc 3095941 ttccatccaa agaaaagccc gcttccgaga aaaagtggtg ggacaaatgg ctggggcgac 3096001 atcattgaaa ataacccggc tcctcggagg ccgggttatt cgtatggttc cttcataatc 3096061 gatggaagaa tgttagacaa tcgagctgaa caatcagttt tgggataaag tggtgaattt 3096121 ctcatttctt cggcgctggc tttcatctcc cagtcgccga ctcatatccc cctaaaaatg 3096181 aaaaaccccg agtcttgttt cggctcggga ttttccatgt cctatttctg tatcaccagt 3096241 ttactcaatg tttacgaaaa atatctcaaa tactttaaaa gttcacaaaa aattcataaa 3096301 ttaattgttt tctggaagca ggctcgtttt taactcatct gaggaacggt cccataggcc 3096361 ctgatcatgc tttttcagaa attcgcctag tacacgcttc gagctgtcgt ccattttatc 3096421 aacgatgatt ttccgtttca tggatttatc catcagattc acatgctcag gcagtgactt 3096481 gtagcctctt ctgatgcttc tgtcgaccgt catttcacag gctgtcacac cagcgtaata 3096541 aggcccctct tcttttctgt caatcgttac ccacacaagc cagtatggtt ttccgttcgg 3096601 cacttcttct ttattcggga gaaatttaat tcctttttca acggtgctgc gggcatgcat 3096661 agcgccgatg tctacgaacg cttctttttc ctctacatca acgaatacgg gagaaatgtt 3096721 atcaaggctg agtgccccta cgccaaaacc gccgtgtccg tctgtcggat cacttttgat 3096781 aatattaaac ccgattgatt ttttcttttt ttcttccatg aagttctacc tcctacaaaa 3096841 gcggttgaaa tatcgctgaa aacagcttta aaatcgaatc tcttcctgca ttgagcatcg 3096901 gccacagcac gtaagatcct agcggtgtca caaacagcac caaaaatacg ataaagccgt 3096961 agctctccgc ctgcgtcatt ttggcacgca cgcccggcgg aacgagatct tctataattc 3097021 gatagccatc gagcggagga agcggcagca gattaaataa aaacaagaca agattcagct 3097081 gtatccaaat agaaaaaaac tgatccagcc ccgtgctgaa cgccgcaagc atttccattc 3097141 cgtacgcatg catcaacact aacaaaaaga aaccaataaa cgcaagaatc aggttactga 3097201 cgggcccggc tatagatacg agcacaccag caagccgggg tttcttaaag aaacggcgat 3097261 tcacgggaat ggggcgcgcc cacccgaatc cggccaccag aatcaaaatg gttccgaacg 3097321 gatcaaggtg tttaatggga ttcagcgtca gtcttccttg ttttttcgcc gtatcgtcac 3097381 cgaatttgta tgcgacataa gcgtgggcaa gctcgtgcat cgtaaacgac acaattagcg 3097441 tgatgacgag gtatggcatt aaagataacg gataatataa aaaacggtcc aagtgagata 3097501 tccctctttc tcaaaatgca agaatttact ttattcagta tactataaga agcctctttt 3097561 tctaaagaga ggaaacgaga taaaggagga ttcagcaccc atgccatacg taactgtcaa 3097621 aatgctcgaa ggccgtacag acgagcaaaa acgcaatctt gtcgagaaag taacagaagc 3097681 cgtaaaggaa acaaccggtg cttctgaaga aaaaattgtt gtctttatag aagaaatgag 3097741 aaaagaccat tatgccgtcg caggcaaacg cctgagcgat atggaataat ctctataaag 3097801 ccggcgcttc gcgcaccggc ttttattatc cctattgagc cagcttcgca ataatcgcca 3097861 agaacgtctt tttctcttcg gctgttaaac gttcaaacat gccatcaatc agctgctggc 3097921 ggttttcgat catttgttca gccgctcccc ggcccgattc agaaagagta atccatacag 3097981 tgcggcggtc attgttattt ctggatctct caataaaccc ttcctgctct aaatgattca 3098041 gagctgtggt cgtggcagag ggagacagtg tgacctcctt caaaatatcc tttatggtgc 3098101 agctcccatg tctgtatatg atccgcagaa taaaccctct tacattattc acgtgtttcg 3098161 gaacggtggc ttcatctaat tgcttcgtgc ttttcaaata ctttgtaagt gcgtgatcca 3098221 gcaaatttgc ttccagtttg tcatggtcca tgtcaatttc cccatttcga gatgcattca 3098281 taacatacga acgatatgat ttacttatta ttttactgat tccgaatagg gaaagtcaaa 3098341 aaagcaaaat gtgaattcac agcttttatc ctacatgcct cgattttcca cctgtttcac 3098401 aagtttatct ttaaaagttt ggaaaggaac gtgttcattc tgctgatgtc cgaatcggcg 3098461 gacgtttacc gcattctcct gctcctcatg atctccaagc accagcacgt acggaatttt 3098521 ttgcacctgc gattctctga ttttatagcc gagcttctca ttgcgctcat caatgccggc 3098581 tcttatcccc gcctgcttca gctccgcctg cacttttctg caatagtcta agtgaacgtg 3098641 cgaaaccggt atgatttgaa cctggatcgg tgcgagccag actggaaaag ccccaccgta 3098701 atgctcgatc aaaatgccga agaaacggtc gattgagccg aaaaccgctc tgtggatgac 3098761 aacgggacga accttctcat tgagttcgtt gatatatgtt aaatcaaatt tttccggcat 3098821 ttgaaaatca agctgaattg tcgcgcattg gtggctccgt ttcagggcat cttttatatg 3098881 gaaatcaatt ttcggcccgt aaaacgcccc atcgccttca ttgatctcat aagagaggcc 3098941 aagctcctca aggacgcgtg ctaaggcacg ttccgacgct tcccaaaggc tgtcatcgcc 3099001 taatgaatcc tccgggcgag tcgaaagctc aacagaatac tcgaaaccaa atgtccgata 3099061 tacctcatca atcagccgaa tcgcttcttt gatctcactc tcaatctgat cctcccgaac 3099121 gaaaatatgg gcgtcatcct gacagaacgt ccgaacgcga agcattccgt ttaaagcgcc 3099181 gctgtattca tggcggtgca cctgtccgaa ttccgccatg cgaatcggca gatcccgata 3099241 agaatacagg ctgtttttaa agatgagcat gtggccgggg caattcatcg gcttcattgc 3099301 gaatcttgta tcatccactt ctgaaaagta catattgtcg cgataatggt cccaatggcc 3099361 tgactgctcc cataaccgct gattcatcat aaacggcgta cgcacctcat cgtagccggc 3099421 atttgtttgc agctcacgcg agaagcgctc cagctcattg cggacaatct gccctttcgg 3099481 caaataaaac ggcatccccg gcgcttcttc agaaaacata aacagcccta actgtttgcc 3099541 gagcttgcga tggtctcgtt ttgccgcttc ttctagcata tgcaggtgcg catccaaatc 3099601 ttttttcttt tgaaacgcaa ccccgtacac ccgctgcagg acttcatttt tgctgtctcc 3099661 gcgccaataa gcgcctgata ctcttgtcag tttgaacgcc ttgatcatcc ctgtagaagg 3099721 aagatgcggc cctcggcaca ggtcaacgaa ttccccttgc tggtacagtg tgatatcctc 3099781 cccgcgcgga atatccttta aaatctcaag cttgagccgc tcgtcttttt gtgcaaacag 3099841 ctcttcagct tcttcgtaag aaacctctat acgtttgatt tcaaggttct catttattat 3099901 gtttttcatt tctttttcga tggcctctaa gtctcctgat gccaagcttt tccccagctt 3099961 catgtcatag tagaagccgt ctaaaatcac aggccctacc cccaatgaca cttcgccgta 3100021 cagccgtttt actgcttggg ccagcacgtg cgctgttgtg tggcgaagca cctgcaagcc 3100081 ttcttgtgaa tcgagtgtga caatcgaaag ctcagcatcc tcctccagct tgaaactgag 3100141 atcaacaagc ttgccgttga cctgacctgc ggccgccttc ttttgcagac tggaactgat 3100201 cgaaccagcc gcttctttga ttgtgatgcc tttcggatat tcctggatct gtccgtccgg 3100261 aagctgaatg tgtacatgtt tgctcatttt agaacactcc ttattcattg ttgtatataa 3100321 aaaaacacac ccgtcccgca gatagggacg agtgtgtgat taacccgtgg ttccacccaa 3100381 gttcccgaca aatactatgt tgtcggctcg gtgctgtaac gcagcataga cggcattggt 3100441 tacttcagtt ccccaatgct gctccaaggc ggtaaatgat attcctaagc tgggaagctc 3100501 tcacctttcc ttccctctct gaaaaccgta actatcattc atgtcctttt catcgcatgt 3100561 attcaattca taaaaaaaca cacccgtccc acagataggg acgagtgtgt gattaacccg 3100621 tggttccacc caagttcccg acaaatacta tgttgtcggc tcggtgctgt aacgcagcat 3100681 agacggcatt ggttacttca gttccccaat gctgctccaa ggcggtaaat gatattccta 3100741 agctgggaag ctctcacctt tccttccctc tctgaaaacc gtaactatca ttcatgtcct 3100801 tttcttcgca tgtattcaat tcaaataaaa aaacacaccc atccctctaa aagggacgaa 3100861 tgtgttgatc atccgtggtt ccacccaaat tcccgatcaa ttacacatga tgatcggctt 3100921 aaagatgctg taacgcagca tgacggtatc agatacttgt tttccctgat acggctcaaa 3100981 ggcggtaagc tgctttccct gcgttaggaa gatctcagct gtccttccct ctctggaaac 3101041 cgtaaaaagc atctcgtgtc cttatcagtg cctgttgttt caataatttt ttatatctta 3101101 ctatatattc ccacaaagcg caatcagtga tttacatttt ttctgacgcg gcagtcccgt 3101161 tatgggcagc cagaaacagc catacaagca atgcagcgag gctgtatgcc gctcccatca 3101221 tcaaaaacgc aaacccggca ccagcatacc aagtggcgga cagatgaatg atcaccccgg 3101281 ttatcgctac gccgaccaag gctccgattt gccggtttgc atttaacgcc gcaccggcga 3101341 tattcgtatg tctttgcccg gcagcctgca tgatcacagt tgtcatggca ggaactgtaa 3101401 taccggtaca gaggttcata acagacatca acaccgccag ctgccaataa ggaaaatccg 3101461 gagaaatcag cacaaacaac agcaatgcaa tgatacagct gaccgccatt gatacaaaca 3101521 taagctgacc ggcttcaaac cgattcgcca gacgggcaaa cagcagattg ccgatcacga 3101581 agaccgccat catcggcagc agctccactc cagccataaa ggaacttgcc cctcctgctt 3101641 cctgcaaaaa aaggctgagc ataaacatgc cgccaaaaag ggcgaaattc agcaaaaacc 3101701 cgataaattg ggcagctgag aagcggccgt ttttgtataa ggacgccggc aggatgggtg 3101761 tttttgcaga aatttcccgc agcaaaaaca gcacaaatgc caaaaccgct gcagtaaatg 3101821 ctacaagaat cactggcgag cgccagcccg ctgaaggccc ctgtatcaaa gcataggaaa 3101881 gaaacccgag agccatcatg ccaagcagat gcccgatgat gttcacgcgg ctgcttttcc 3101941 caggaacgcg gctgaggatt cggtaagctg aaatgagcgc agcagcccct attggcacat 3102001 tgatcagaaa aatactctgc cagcccgcca actgtaccag cacgcccccg ataaaaggcc 3102061 caagggctga agcggcggaa acaagcgcgg cccacagtcc aaacattctc gcccgcgccc 3102121 gctcatcaag gtaagaggca gccaaaaggc tgagtgagct tggcataaac aaagctgccc 3102181 caattccctg tatgagacgt ccggcaatca gcatctgccc atttatagat gcagcgcata 3102241 gacaggaggc cataacaaaa acggctagac ccaagatata gatcgtcttc gagccgaaac 3102301 ggtcagccaa ggctccgccc gccagcagaa gcgacgcaaa agtaagaatg tacccgtcca 3102361 caacccacgt tacacctgaa agtgacattg aaagagtgtt tttcatatca gccatcgcca 3102421 cattcacaac ggtcacatca agagttgcca tgaggaaacc aagtgcgagc acgatcagca 3102481 cggatatgcc tgttgatgat gttgattctt gtatagaccc gctatttttc attacaattg 3102541 ccctttcact tgcttgatta cccaatcatc tattttttca agatcataca attccccgac 3102601 tctgtccata acatgctgca aggattcttc tctcataaga ttggaccatt tatcctcgat 3102661 ttccgccatg actgtctcca gcacacagtg actttcaccc tcaaatacag attgcagcaa 3102721 gcctttcccc tgatacatcg aacctctgcc ttcgaccgct tgataaacat cataaagcgt 3102781 aatgtcagcc aaaggcttcg tcagggtaaa accgcccttc gtccctggta aggattctgc 3102841 caaaccggct tgaaccaatg ttctcatcag cttcttcaag taagacggag acacgcgcaa 3102901 tcgctggctt atagcctctg acgtcaaaga agcctgtacc ggcagccgtg acagtaacag 3102961 cagcacagaa accgcctgct ccattcctga tttcattttc atcctattca ctcctgattc 3103021 attatggata actattatcc ataatgaatc tcttagcagc ttttgtcaat aaaaaaagca 3103081 aaagaaacgg atcatttctt ttgcttggta tggttaacaa atctgcttca gttcctctat 3103141 gtattgaagc gcttcgtcat attcttcatt tgtatatttt tgcttgcttt tgatggtaaa 3103201 gactttttct ttcttttcct catcctcaag cccgtcaaag taaaggatcg tggaaaccag 3103261 ctctaaaaac cgtgatgaac ggctgtttac actgtcgata tagcctttca tatccggcat 3103321 gtccagatca gcatggtcta aaaatgcgga gcctgtctca gtcagcgaat accggtattg 3103381 aaagtagccg cccttttttt ccttcacctc atgcagaaat ccaaggttgc acagctcttc 3103441 aatctggagc gtcagttcct ctgaatatgg tccgtaaaag tgaaaatcat atttctcata 3103501 gaaaggaaac tgcattttct tggcgatata aatcattttc tgcagcttct ttcgcccgat 3103561 gatttctcca gaatccgaga acaccttcat cagttttgca tgttctttca acaaattccc 3103621 gacatctcct ttttccttct ttccaatttc tatgtcagtc ccagcagctg ccggattttc 3103681 attttcgctt ccggatgttt agtgccgtca caaatcaagt cctttggata gtacagcttg 3103741 tggtccgtcc gccgtttacc tgagatggat tccacaatag ccgactgtct ggacagctct 3103801 ttaatttggc cgttttgcgt caagagatgg atcggcagac gctcctcttc ctctcctggt 3103861 cggtaaaaat cgtatggcag atctgatgaa gaatcaacga ccaaataata gctcggatcg 3103921 atccccgcct ctttgaacaa tgaagtcagc tcaaaataag ccgacatttc ttcattcgga 3103981 ttgaattcaa cgtattggaa aagctggcgg ttaatgaatc tgcggcacaa gtcggataaa 3104041 atcgcgtctt cttcatcctc ccaggcctgg aagtaataca aaataataga ttcatccagc 3104101 tttacataat cctccagtgt caattttcct tcaaaaatag aatagaaatg aaccggagcg 3104161 tgagtgaaga catagccttc atcgtgcagc tgcttcgccc tgtgaagaat cttcgttaaa 3104221 atgacctctg cacttctagt cacaggatgg aagtagacct gccagtacat ttggtaacgg 3104281 ctcatgatat agtcttcgac agcgtgcatt ccgctttctt taatgacgat ctgatcctcg 3104341 cgcggccgca tcacccgaag aatccgctcc atatcaaaat ggccgtagct gacgcccgta 3104401 taatatgcgt cgcgctggag gtaatccatg cggtctgcgt caatctgact cgaaatcagg 3104461 ctgaccactt gcttgttttt atatgttttg gcaatgactt cagcaacatc ctgagggaaa 3104521 cccgggctca cctttctgag cacctgatta acctccgtgt ctcccaaaat gatacctctt 3104581 gtaaaatcct cgtggtcaag gtgaaagacc ttttcaaatg aatgcgagaa cggcccgtgc 3104641 ccgaggtcat gaagcagcgc cgcggccaaa cagagttcgc gctcactgtc atcccattca 3104701 gggcggcctt taaagacgtc atcaaccatt cttctgacaa tttcatagac accgagagaa 3104761 tggttgaacc ggctgtgctc agccccatgg aacgtcaaat aggtcgttcc gagctgctta 3104821 attctgcgga gacgctgaaa ttcacgggtt ccgatcaaat cccatatcag cttgtcccga 3104881 acatgaacat agcggtgcac cggatcttta aacacttttt cttctgataa ttttccattt 3104941 ggatacgcca tcgtcattcc ctcttttttt tagccgtgtt tctattatat cgactctatt 3105001 ctttgaaaac atccttgaat ttgcccggcg atttgttcca tcttcatgaa aaacacatct 3105061 tgtgaagcaa aaaagcctga cctgagggcc gaggctaaga aaaaatatgt ttttactttt 3105121 ttattttctt ttttactttg tcaatcagct catcctctgt cggagctgac agcgggcgat 3105181 tgttcacaaa agcaaatgat tttttccgtc cgggcccgca ataagattgg catcctacct 3105241 caacctttgc gtccgggtcc acttctttca aacgcggcag caatgttttg atattagtgg 3105301 cttggcaatc atcacacact cgaaattcat tagccatgac gtacgcttcc cttcatttct 3105361 atgttcatct atgtgaataa cctaaaatca cgtttcaaaa aaaatcacat cacacttcat 3105421 tttacaagga ttcgactgtt cctgcaagcc gctccatcct tcgtatctcc tattctttca 3105481 gccaatttgt ataaatattt tccaacctgg acattctaat accatgaaaa gaaaaatggg 3105541 agttgagata aatgacaaaa cagcgacaag acgcttggtc agaggaaaac gatctgcttt 3105601 tagccgaaac agtgcttcgg catgtgaggg agggcagcac tcagctgaac gcctttgaag 3105661 aagtcggcga taaattaaac cggacatccg cagcctgcgg attcagatgg aacgcagtgg 3105721 tccgccatca atatgaaaaa gcgcttcagc ttgcgaagaa acaacgaaaa cagcggatga 3105781 gagcgctcgg aaacgggcag cccgcgaaaa aaagattatt atatcagcct cctgccgttg 3105841 atcctgaaat cattcaagaa accgctgcag aagagccggt taaaacggaa acaccatctg 3105901 tcgaaaatga gcaaccttta atgtctggcg aacacatgcc ttttgttgat gaaagcttta 3105961 aggaagagtt agctagtcta tcacacttat tgtctcctca aacgcctgca gctgcgcctg 3106021 agatgacgat gaatgatgtg atccgcttcc tgcagaatta cgaaggcaat cacgagcaat 3106081 catcagcatt aaaaatggaa aacgagcgtt taaagaaaga aaatcaggaa ttgcaaaaca 3106141 aaacagagca gctagaggca gaagttcaaa agcttgaaaa agaccaaaaa acgatccaag 3106201 aagattatga aaccttggtg aaaattatga acagagccag aaagctagtt ttatttgaag 3106261 aagatgaaca tgcctctccg tccttcaaaa tggaccggaa cggcaattta gaaaaattag 3106321 cggaatgaca tagaaaaatc ccaaaacggg cagctgtttt gggattttcg ccatgtgcaa 3106381 aatccccttt tctattgaga aaagagaatt tcctcatttt gcagccggat cagctattct 3106441 tgtaaaatga ggccaagctt atgtgaatct attaagacat gtgagctgcc tcggccgttt 3106501 tttgtttccg aggcgcagca gaaatgacca aaagccccag catcataagc gcaatgccca 3106561 gccacgagga aggcgaaagc atttccccta tgaaaaacac gccaagcaat gaagccgtca 3106621 gcggttcagc taaagacagc gtgaccgccg ccgaggccgg aaccccggta agccctttcg 3106681 caaacaaaaa gtatgcggca catgttgcaa ttaacccgat gtaaaggctt gttcccagtc 3106741 ctctaggggt caatatccac gagatatcta actgccataa tagcggcgtc agcaagatgg 3106801 cgctgatcat gaatacaacg gcggaggtcg ctcgcggagg ctgggttttc atcatcgctt 3106861 tactgatgag cgtatagcct gcaaaagaag cacccgctcc aagcgccata agaacaccag 3106921 ccacatcaat ccgaacattg gaactgtcgg aaaacagaag ccagcaaccc gctaaagcca 3106981 gcacagtcgc aatccaccag gagtttcgcg ggcgtttctt caatacagcc cattcgaggg 3107041 tcccggcaat gataggcgca ctgccgatgg caatcacagt tcccactgca attcccgttt 3107101 ctttaaccgc tgtgaaaaac agcggctggt aacacgccat acaaacagcg gctaaaaata 3107161 cgagcggcca tgcccaattt ttcacgtgaa gctcccggct gatccaaacc gcaagcagca 3107221 tggcgcttcc tcctattaat aacctgaacg ctccaaatgc cagcggtgtg gcgctttctg 3107281 gagccaatgc ctgaacggtt cccgtggtcc cccagaaaaa agccgcaatc aatacaaaaa 3107341 ggctgtaaat attccccttc atctgcctct cccctttaat atggatgctg atgtcatttt 3107401 atcgtttttc tttttgtcgt ggttatctgt atgtaagaag gacttatctg aaaataagat 3107461 tattgaggta aaatgccgct tgagataaaa aatgcatgcc ggcatataca gccggcatgc 3107521 gaagaacgtt cacccaaata cctttgcatt ccgctcagcc atccggacga ggtttttctc 3107581 aaattccatt tcctcatcaa tggacagtcc agctgaataa agatgggtgc ttaacgcttt 3107641 taattccgtc aataaagcga acattaagtc ttgtacggag atgtcttttt gaagaagctc 3107701 acttaaggac gccatcgttt ccggacgtat ttccggatag acgccttttt tatcgttttg 3107761 tttgtctttc agcgccgctt gatagaatcg tctgatcaag tcggcccttt cactgccgct 3107821 tttatctgca cagagataaa tttgaacagc gactccgccg cgaacgcgtc tctgagagat 3107881 gccggcgaac tttttgccat ttatactgag gtcatagctg ccgggacaat aagacccttc 3107941 aatttcatag gcttcgatct ttgcgttgta cggtctcagc attcgtctca tcagctcgac 3108001 catcgcttca tatcctttgt ctatatcgat gcctttcttt tcgtcctcga atatgagaga 3108061 gatatttaaa acaccgtcat ccaatacgac ggcaagaccg ccggaattgc gtacgatcac 3108121 acggtatcct tcgctctcca gcaaggagat accatcctgc aaaaacggga ggcgtgtatc 3108181 ctgtattcca aggacaattg tatcgtggtg cacccatgag cgcgctgtcg ccggcgacac 3108241 gccttttccg acggacatgc atagcgtatc atccattgcg aaggattgct tcgcatcaaa 3108301 taaagggccg agactggatt ggtcaatgac tctccatttc ggctgcatca gtaaatcaat 3108361 cggttggttt gccatctatg taaaaccctt tcatgttagg cttattgaac gaaaactatt 3108421 atatcatttc agcagctgtg attgataatt gcttttcagc atcgtaataa aaatttcttt 3108481 attttttgta ttctccatga gaggagaatg aatgtaagac agcttgcgct ttaacgagaa 3108541 attattaata tgcagaattg aaatttcgcg gtggatcaaa tccttacgca gcacgcttct 3108601 ggatagaacc gaaagtccca tgccgttaat caccgcttcc tttacacctt gattgctgct 3108661 gatggtaaac attgatttcg gccgaagtcc atttgaactg agtacatgat cgagatattc 3108721 tctcgtcccg gagcctttct ctcttgtcac ccacgcttcg ttctgcaaat cgctgatcga 3108781 aatctctttc cgcccggcga gcggatgctg atttggagcg gcaatgcaca tttcatcctc 3108841 catgaacggt tcaatttcca gctcattctc gtttgtatgt ccttcaatca gcccgatatc 3108901 agcctgaagc atccgcacac gctcgctgac ctcctctgta ttgccaatca tgacatctag 3108961 attcagctct ggatacagct tttgcagctg ggccaatagc ggcggaagaa tatactcacc 3109021 gattgtaaag cttgcagcta ttttcaattc acccttcaca tagtgatgat gcgcatagat 3109081 ttcagccttg gcttgttcgt agagaaacac catttgcttt gctctttgat ataaaatgtc 3109141 tcctgtcggc gttgtcgtaa agtgttttgg cgacctgttc agaagagccg tttgaaattc 3109201 tttctcaaga tttttgatat gcagactgac gctgggctgg gagatcatca gcttttccgc 3109261 cgcttttgtg aagttttttt cttctaccac cgctataaac gttttcagca cgtcgtaata 3109321 caaaaacccc acccctgtca ttaatgaaat atatggttat gattagtttt ctttattgta 3109381 ctcatatcat ccgtcttggt aaagaagggc tatacagaag cgcaaaaaag gcagccctcg 3109441 gtcgagagct gccattgtct tcaattttat tacagtgctt gcgccgctgt aattaatgcg 3109501 agattgtaaa catcttcagc gttacatcct cttgaaaggt cgtttacagg catatttaaa 3109561 ccttgcagga ttggtcctac cgcttcaaag ttgcccaaac gctgagcgat tttatagccg 3109621 atgtttcctg cttcaagact tgggaatacg aatacgttag cgtccccttt gatctcggaa 3109681 tccggcgctt ttttctcagc tacagatgga acaaatgcag catcaaattg gaattcgccg 3109741 tcaagtgtca gttcaggcgc tttttctttc gcgattttca ctgcatccgc tactttttct 3109801 gtttcatcag attttgctga gccttttgta gagaagctga gcattgccac gcgaggctca 3109861 atgtcgaaca tttttgccgt attggcactt tcgatcgcaa tctcggcaag atcttggctg 3109921 tcaggtgcaa tgttgatcgc gcaatctgcg aatacgtatt gctcttctcc gcgagccatg 3109981 atgaacacgc ctgaagtctt tttcacgcct tcttttgttt tgatgatttg aagagccggg 3110041 cggacagtgt cagcagttga gtgagcagct ccgcttacaa gtccgtctgc aagtccttta 3110101 tacaccagca ttgtaccgaa gtagttctcg tctaataatg ctttacgagc ctgttcttca 3110161 gtcgctttgc ctttgcggcg ttctacgaat gcttgtacaa ggtcttccat gccttcatat 3110221 gtatgaggat cataaatctt aacgccgccc agcgtaaggt tcaattcttt tgcttttgct 3110281 tggatctcat tttcattgcc gatcacaatc ggattcagca ctttgtttcc tgcaagcttg 3110341 ctgaccgctt ctaaaatacg ctcgtctaag ccttcaggaa atacaatttt aacgtctttt 3110401 ccagctactt tttcttgcac tgttgaaaat aaatctgcca caataaaacc tcctcaaaaa 3110461 gttacaaaaa cgctttcttt tactagcata ctcttcttcc aatcaaattc aaacagccaa 3110521 ctttcattat agcgctttca taaaaaaatc ttatttttct aactaattta agtgactcaa 3110581 tcttccctta taggttcttc tattttgatg gagttatacg gaagggatgt tcaaggtttc 3110641 tccacagtag aatcggataa actatggtat agtgaaggca atcatgaaaa gataatggga 3110701 gtgaagataa atgagtgaac agcaaatgac gaatgaagcg gcaaaaacgc ttgacggctg 3110761 gtatgcgctt catgatttcc gcacaatgga ttgggcttcc tggaagcttc tgtccagtga 3110821 tgagcgccaa tctatcatac atgaattcac cgggttgctt gaaaaatggg gcgtagccca 3110881 aaaagaagga aaaggatcgc aaactcttta cagcatcgtc ggccaaaaag ctgattttat 3110941 gctgatgatc cttcgtccta caatggaaga attaaatcaa attgagcttg aattcaacaa 3111001 atcaagactt gctgagttca ccattccggc atactcctac gtatcagtgg tagagctgag 3111061 caactacttg gcaagcggtg acggcgatcc ttatgaaaat ccgcatgtgc gcgctcgcct 3111121 ttaccctgaa ctgccggaat ctaaatatgt atgcttctat ccaatggata aaagaagatc 3111181 tggcaacgac aactggtata tgctttcaat ggaagaacgc agaaacttga tgagaagcca 3111241 cggtttaatc ggccgcagct atgcgggcaa agtcaaacag atcatcaccg gctctgtcgg 3111301 ctttgacgat tacgagtggg gcgttacatt atttagcgat gatgtccttc aattcaagaa 3111361 gctagtgtac gaaatgcgtt ttgacgaagt cagcgctcgc tatggcgaat ttggttcatt 3111421 ctttgtcggc aatcaccttt cgcttgatac acttcctcaa ttcttatatg tataatatcc 3111481 ccgagctcgt ttattgagat aaggactgat cggccttctg ctcaagtttg ccgtactttt 3111541 tatatgcgaa tacactgagc acaaatccga ggactgtgat ggcggcgcaa atcaatccga 3111601 cagctgcata gccgtatgcc acatatacgg gtcccattaa agcagaacct aatgtcacgg 3111661 ccagattcga ggcgagactg taaaacacca tgacttttcc tcgatgacgc tctgagcagt 3111721 cactcaaaat ggtgctgagc agcgtcaccg tcaaactttg cattaatccc caaataaata 3111781 ggctggcgat taacagaaac atagacgccg gcgcatatgg taaacacgcc agcagaacgc 3111841 tgatgacccc cagcgcaatc aaaagggagc gcatttttcc gatgcggtcg gctatctttc 3111901 ctgtaatcac actcatggaa aacccgattc cataaatcat gataaataag cccgcagccg 3111961 tgtttcctcc ggtaaaaacg tcctgaagat aggtgcctaa aaaggaatac ataccgtaaa 3112021 aaccaatcat attacaaaag gttattgtga tataaacagg tacacgaggg actttcagcg 3112081 catcccggaa tgttcctgcg ggctcttcta tttcttcctt gccgctgttt ttatgttggg 3112141 catggcggcg catttcaagg agaatcagca gaacaactaa aacacccatc agggcgaaaa 3112201 tccaaaacgt ccatctccaa tgcaggacgc cgccgataaa tgatccgagc ggcactccga 3112261 aaatcagcgc cagcgaccag cttgaaacga tcagtcccat caccttgccc cggtatgtat 3112321 aaggaacacg atcaccgaca actgcgtaag cggtcggaac aaacgctccc gcagccaatc 3112381 ccgaaagcgc ccggcctaaa aagaagaaaa aaatattttg agctaaagcg catatcaccg 3112441 ttcctatgat aaaaatcata agcccggcca ataagctcag ttctctggag tatttatcgc 3112501 ctaatggaac caaaagcggc gcaccgataa aaatcataac gccgtaaata ctgatagata 3112561 acgcaaggac gctgacatct gagctgaagg cttttgctaa atccggcagc agcggtgaga 3112621 tcacaagctc ttcagatccg gctgcaaata cccccatcgt taaagccagt gccaacaata 3112681 acggaaaatg atgttttgtt ttgatgtcat tgttttgatt gctgttcatt ctttctcaaa 3112741 cacctcttcc ataatcttct tatcataaag ttgtattata gtttagcatt gttttttctc 3112801 tatttacaat tcgaacgaaa tatttataag ttttattatt ttcatttaaa tcccattata 3112861 tatttctata tttcattcta aaaatacatg aggatgtaac acgtaaaaaa agctctccgg 3112921 cctcccggag agctttttct attgcgcctc tgtctgcttt ttttcaatcg tttcatgatt 3112981 tatacgcttt ttgatgctta gatgatagta tgcataacag aaaataatga tcggcacacc 3113041 gcagtataag ccaattcttt gatccggaat gaaaataagg ctgatcaaca cgcagccata 3113101 taaacaaaat ccgagaatcg ggactagcgg ataaagcggc gttctgaact ccagatcatt 3113161 cacatttccg ccttctgcca ggaaacgcct gcgaaagaaa aattgcgacg cacaaatgga 3113221 catccacgcg acaactgtca ccatgcccga gattgagata caccataaat acactgtttc 3113281 tgcagccatg acacttgtca gcagcgaaca gcctgaaatg cctagcgtaa tcagcagggc 3113341 attcatcggc acgccttttt ttgtcagtct ggtgagaaag gagggaccca tttgatttga 3113401 tgaaagtgac cacatcatac gcgacgccgc atacaatccc gaattagcaa cagataaaat 3113461 ggccgttaag atgacaaagt tcatgatatc tgccgaaaat gggatgccga tttgatcgag 3113521 tactgctaca aacgggcttt caatcacccc cgccgttttg tacggaagga tggcaaccaa 3113581 gacgaacata gcgagcacaa agaaaaacag cgtgcgccaa ataacatttc gaatggactt 3113641 tggcagtgtt ttttccgggc tttcactttc ccctgccgca atgccgacaa gctccgttcc 3113701 ctggaacgag aagtttacca tgaccagcgt aaacataacg gccagcaccc cattagggaa 3113761 aagccctcta tcagtcataa agttagacaa aaagggtgtc tcctgtccgc ctttaaagtc 3113821 aatcaagcca aacacagcgg ctccgccaat cacaataaat aatatgatcg ccgccacttt 3113881 gatgcttgaa aaccaaaatt ccatttccgc aaagcttctg acagagagcg cattaatcaa 3113941 aaagatgacg atgccgaaca cgaggcacca tatccagatc ggaacggagg gcagccacct 3114001 ttgcatcaaa atgcctgctg acgtcagctc taaccctact gtattggccc agctgaacca 3114061 atacagccag ccaatcataa agcctgtcga ctgtcccaga aatttagtgg cgtaggcctg 3114121 aaacgatccg gccaccggca tggcaacagc caattctcct aaacaaagca tgacgagata 3114181 cattaaaaat ccgccgatga tatacgcggc aatggcgccg agcggtcccg cctggctaat 3114241 ggtaaagcca gagcctagaa acagcccagt gccaatcacc cctcccaaag caatcataaa 3114301 caaatgcctg cttttcatgc tgcgctgcaa ttcattttta tgattctgca tcatccttcc 3114361 ccctttggtt cttttgccgt gatggtcatc cggtagcttt gcaaaagatg aacggtggtt 3114421 tgctgtatga ggagaggcaa tacatgaaat gtgtacggtt tatagactcg ttctgtccat 3114481 ttatggccgt cttttccgta cacgcccata ttaatggatg gaatattcag cttgcgtatg 3114541 tctttgaacg gaatggtccc aatcatattc cacccaggga agttcctgat aaaagaatca 3114601 atttcgccat cggtttcgtg cagtgataaa aaactgccgt ctgccaagta ggggaaaaac 3114661 tttttgaaga caaatgtttc gcctgtcgat tcagcggttt tgtcagccgc ttctttaatc 3114721 acatgctgca aaagctgatc tcttgcgcta tcttctttca aatagttatg cggcaggtaa 3114781 ggaggtgcgt aaaatagaat gacttttgcg ccttgatcgg ggtcaagctt ttgaagctct 3114841 tcgattgcct gaaagcatct catgcgaagt tcaaggtgct cgttggcttt gaatgtctgc 3114901 tcgatacact gctcgggatc tattccccgg tttctcagct tttctaagta ttgctccagg 3114961 ctatacactt gaatgcccca tgataaatgt ttctttggca ggttggctct ttttacatat 3115021 tcttcgtaat aatctgataa tttttgttct gtctcccggc atgcttcctc agtgacttca 3115081 ataagcaaat ccatcatttc ttttgctgtt ctttcataaa taaaacaatt gaaatacaag 3115141 ctggtgctga cagccgtttg cacattatag gattccttgt tatcacgctg atacaaacag 3115201 gatgggggca gaaccaactc cccttcaacc ttttctgcca gatggatgtt attgtggaga 3115261 cggcttgtga tttcagatga aatgaaattt gggtcaatcc ctgccagtgt atcgccaaca 3115321 tggacttcac gcccgtaaat gtaaaagcaa ggcaacagtt ttcccgcggc tccggtatag 3115381 atatatcttg tctgatcacc atcgtaaagc ggggtaataa aatccgtatt aatagcagcc 3115441 aaatagtgaa gctgtttttc tttttttagc cggttcagct ctgaaatgct ggcgagaatg 3115501 cccgaatgct ggctctcctc atcgggattg gccataaaca atacatttcc cggcaacgtc 3115561 tcaaggttct ccgaaaaatg caggagattg gctaaatgca cggcgatgcc gctttgcata 3115621 tcgacagatc ctcttccgaa catccactcg cctgatttgg catcccgctg aacatcctga 3115681 tcgaactcat agcggctgaa atactcggcc aatttctcac aatcaaaagc gatatccttt 3115741 aaagggccga aatcttcaat tccaactgta tccagatggg catggtaaat gactgtattt 3115801 cggctttctc catgtccttt aataaacgca aaaatatttt tgcgtttgta tgggtcattg 3115861 ggaatggcct gttcccacac atgactgggg ttttcctgaa aataaggata gctcgtgatc 3115921 acttctttga tgaaatctgc ttttgtccct tctccaacgg tgccgttcac gctgctgagg 3115981 ctgaccagag atgctgtcag cgcctccact ctttcagccg gattcatgtg actgattttt 3116041 gtatactgca taaattgtcc tcctgatcaa aaagttgaaa tcgtgcgatc cgctaaagaa 3116101 tcgcacgatt ttatttctct caaatcaaaa agcttcggac gttgttttgg cttgcatatg 3116161 aagaattaag taatcgggac cgcctgcttt tgagtctgtt cctgacatat taaaaccgcc 3116221 gaacggctga tagccgacaa ttgctccggt acatcctctg ttaaaatata ggtttccgac 3116281 atggaaatcc tcgcgcgccc gttcaatgtg cgcacggttt ttcgtcagaa gcgcacctgt 3116341 taatccgtat tccgtgttat tggcaatctc cagcatatga tcgaaatcac gcgctttgca 3116401 aatcgcaaca accgggccga aaatttcttc ctgcatcaag cgggcgtttt catcaacatc 3116461 tgcaaagatc gtcggctgaa taaagtagcc ttttgaatca tcgccttctc cgccggccaa 3116521 tagcttgcct tcagatttgc cgatttcaat gtatttcatc actttgttgt aggatgcttc 3116581 atgaatcacg ggacccatat acgtatcagg atcttctgga ttgccgacag tcagcgtttt 3116641 ggtcagcgcc acagcttttt ccaccacttc atcatacaca tcctgatgaa tgaccgcgcg 3116701 ggagcccgca gaacacttct gtcctgaata tccaaatgct gaatacacga tagaggatgc 3116761 agcaaggtca agatcagcgt ccttgtcgac aagcactgtg tcttttccgc ccatttctgc 3116821 aattacccgt ttgagccatt tttggcccgg ctgcactttg gcagctcgct cataaatccg 3116881 gcagccgact gcacgggaac ctgtaaatga gacaaaccgt gtcttcggat gctcaactaa 3116941 gaaatcaccg atctccgcac catctcccgg aatgtaattc agaacgccgt ttggcagacc 3117001 cgcttcctcc atgacctcga caaattttgc tgccactacc ggggctgcgt cagccggttt 3117061 taagagaatc gtatttcctg tcacaatcgc tgccaccgct gttcccgcca taatcgcgag 3117121 cgggaagtta aatggagaaa tgacgatgcc gacgccaagc gcttcgtaat gatattgatt 3117181 gacctcgcca gcacggctct tcaccggagc cccttccttg agctttaaca tttggcgcgc 3117241 gtagaactct aaaaagtcta tcgcttcagc cgtgtccgca tctgcttcct tccacggttt 3117301 tcctgcttcc ttcacaagat agcttgaaaa ttcatgcttt cttctgcgca aaatagccgc 3117361 tgccttaaag agaatatttg cgcggtgctc cggtctttgt tttttccagg aatcaaatgc 3117421 ctgcaatgcg gcttgcatcg ctttttcagc aagctcttga tccgctgtag acgcgtaccc 3117481 aatgatctct tctttatttg ccgggttaat agaaatgatt ttgcggtccg tttcaatttt 3117541 ttctccattt atgacaagcg gataatgctt gccgagctga gtgtttacaa aggccaatga 3117601 ctccccaaat gcagttttat tctttgcttc cgtaaaatcg gtaaatggtt cgtgcgcgta 3117661 tgtgactgtc atatgtagtc cccctcgtgt tatgaaatat atcttcgcat atgaataaaa 3117721 atgcaagaat catgccattt tcttgtcttt tgctgaaaaa acttgttgaa tcgaacagaa 3117781 atttgtctaa caggtgatca cctttctctt tttccgatct tgaacgcaaa tttattttgc 3117841 gttttttgct ctttacgcaa aaaacaaatg caaaattatt ttgcggaggc ttctcaaatt 3117901 agacccatcc gcggaaacgc gatgcttctg ccgattttct gatgcccgtc atgtaagccg 3117961 ccaaacgcat atccacttta tgtgttgccg ctgtttgata aattgtttcg aacgagctga 3118021 ccatgacgct tctcagtttt tctgcaacct cttcttccga ccaataatat ccttggttgt 3118081 tttgcaccca ttcaaaataa gaaaccgtga cgccgccggc actcgctagg atatccggca 3118141 caagcagcac gcctctttca ttcaggatct tagtggcatc aatggttgtc gggccgttcg 3118201 ccgcttcaac gacgattgac gcctgaatgt tatgtgcgtt tttggctgtg atttgattgg 3118261 agatcgcggc aggcactaaa atatcgcaat ccttttcaag cagctcctca tttgtgatga 3118321 cgtcagtaaa taaattggtg accataccaa agctgtcccg tttatcgagc aaataaggga 3118381 tatcaaggcc gtctgggttg tagagcccgc cattggcatc agaaatcccg atcaccttcg 3118441 cgcccgcatc gtgcatgaat ttggccagga agctacccgc gtttccaaag ccctgtatga 3118501 tgatgcgcgc gttttgcagc ttgatccctt ttttcttcac cgcctcttca atacaaatcg 3118561 tgacgccctg tgccgtcgct gtttcccgtc cttgcgatcc tcccaaaaca agcggtttac 3118621 ctgtaataaa gcccggagaa tcgaattccc gcagccggct gtactcatcc atcatccacg 3118681 ccataatctg cgaattggtg tacacatcgg gagctggaat atcctttgtc ggaccgacga 3118741 tctggctgat ggcacggaca taccccctgc tcagcctttc cagttctcca aatgacattg 3118801 tccgcggatc acaaataata ccgcccttcc cgccgccgta aggaagattg gcaatcccgc 3118861 atttgagcgt catccaaatg gataatgcct ttacttcctc ttcattaact tctggatgga 3118921 agcgaacgcc cccctttgtc ggaccgacag catcattgtg ctgtgaccgg tagcctgtga 3118981 acactttgac gctcccattg tccattttga ccggaatgcg gacagtgagc attctctgcg 3119041 gctctttcat gagttcatac atatctcccg gataacccag cttccgaagg gcttccttaa 3119101 tgattgtttg ggtagacaga aataagttaa gagcttcttt ttcttcatct ttcgagactt 3119161 gctttgctga catctttttc acctcattgt ttttttggcc ggctgtaatg taagcgcttt 3119221 aaaaaatcag cccgccaatt cctttcttca ttggattcac ccttatcatc atgcaagatc 3119281 cgtaccagct tttgaatcca caaaaaaaga gactgaaaac atctcagtct ctgactacaa 3119341 atctatcgat taacggggat caatcaccag ctgcgtttca gcataaaaac tgccgattcc 3119401 caaaccgttt actacatcgc ctttaatcgt gtaagtgcct gcgcgaggaa gagttttacg 3119461 caccatgaca aggtcaaatt cggatgcgcc taacaaatca agcgtaagcg ggagtctgac 3119521 tgtttttcca tcgtttaaaa tctgtgtttc tttcagtgtt cttccattca ctgaatctct 3119581 tgtcgtagca tgaaacccgt caggaaattg aaattctacc gctccaagag aaagcaccgc 3119641 atttggttta tatgtcactt caatatcaga aatggtccac tctttcgtgc tgttaactgt 3119701 ttttgcctcg attgatgcag actgtgcatg agcttggccc gaaggaagta agattgatag 3119761 taaaacagct gaactgatga ataatgaaga tacgaatgaa gttcttttta gcatgacatt 3119821 tccccctaat tgattgttga aatttggcca gagcgtcctc tgcagaaaaa gcgctttttc 3119881 ataattcgcg aattaccagt tctttttctt aaaaattaat ctatcatcat tttccatgga 3119941 agtaaatgtt ttttaaggaa tattaacact tggaattcaa tgagaattcc ttcctgttta 3120001 tacaaggttc aaatggacga tttccctctc tttttctagt aacatctgcc tgacatttta 3120061 tatcttttat cctattttaa aaaagggcaa aaaaagtcga agatgcctct gctcttcgat 3120121 tgatcacgtt cctattttta tctgaattca gtgttccagt taaaaccgat cgtctcatca 3120181 tcccacggaa ttcttttttc atcaggctga tccgggttat acgacatggt ggtaaaatag 3120241 ataattgtca gcggcgtctc tcccagcact ctatatccgt gagccacccc ttttgggatt 3120301 aataacagca tcgggttgtc ttcgcccata taatagacgt ccgtttctcc ttttgtcttt 3120361 gaatcctctc gaagatcgta taggacaacc tgagcgtggc cggttgggaa gaaccagaga 3120421 tcatcctgct tctcatgata atgaaatgcc ttaatcacac ccggatagct tttcgaccaa 3120481 gaggcctgcc caaaatgctc aaggagattc tcatcgtccc ggaccagctc agcaaaaaag 3120541 cctctgtcat cgctatgctt catcaatttt ttcaccttga ctccatcaat cacacgcact 3120601 gctcctttcc tgcaaatact ctcgtaacgc ttcccgccag tggcgggggc ggatgccggc 3120661 ttcttcaata gcccgatggc tcagcacaga gtatgccgga cggggcgttt tgttcccgta 3120721 ttcctctgtc gttacagaca aaatggctgt ttccagcccg ctttcttcca taattgccgt 3120781 cgcaaactca taccagctgc atatgcctga attgctgaca tgatagatgc ccggcggatg 3120841 gctgaacagc ttgatgaccg cttctgctaa atccttcgta taagtcggcg aaccaatttg 3120901 atcgctgaca acccgaagct cttgtttcgt ttcagcaagt ttcagcatgg tttcaacgaa 3120961 attactgccg ccatgtccgt acacccacga tgtcctgatg atcgtgctgt cttttgtcgt 3121021 taatcgtatc agttcttctc cgagcctttt gcttttgcca taaatggttt tcggatcgag 3121081 gggatcgtct tccctatatg gctgggttcc tttcccattg aatacatagt ccgtgctgat 3121141 atgaacatat tgagctccga tgcgggttga ctcaagcgct gtataataag cgccgattcc 3121201 gttaatcaag tacgctttat caagctcttt ctcgcattga tcaaccgacg taaacgcggc 3121261 gctattgacc acgatatccg gctgataatg gccaaacgaa tgccgtactg agcgctggtc 3121321 agcaatgttc atcatcttct ttgttaacgc aatgacctca tatccggctt gcttcagctg 3121381 gcggcatagt tccaagccaa gctgtcctcc cgccccagtc accaatacct ttgtcaatca 3121441 gatcaccttc tcatcggtca ttgtctgtat accactgaat cgtacgcgca atgccttctt 3121501 caaacgtcac ttcctgccgc cagcccagtt cgtttttcag ctttgatgca ttgatcgcat 3121561 agcgccggtc atgccctttt cggtcttcca cgtgggcgaa caattcctca cagcccagat 3121621 gcttcaaaat gacactcgcc agctctttat tcgtgcgttc atttccgccg ccgatgttat 3121681 acacctcgcc gtcggtccct ttttctaaaa tcagcttgat cgcgcggcaa tgatcctccg 3121741 caaacagcca gtctcggatc tggagtccat cgccatacag cggaacaggc aggccctgct 3121801 tcgcatgacg gataatcgtc ggaatcattt tttcgctgtg ctgataaggt ccgtaattgt 3121861 tgctgcatcg tgtaatgatg gccggaagct tgtgggtttt cacataagac aacacgagca 3121921 aatcagagct tgctttgctg gctgagtatg ggttattagg agaaagcggc gtcgtttctg 3121981 taaacgcggg atcatccgct tttaaatccc cgtatacctc atctgttgaa atatgaatca 3122041 gcttcttggc ttttcctttc aagaccgctt ccgccaatcg gtatgtcccc atgacatttg 3122101 tggtgataaa cggctccgct tgggaaatgc ttctgtccac atgcgattct gctgcgaagt 3122161 gaatgacgcc atcgtaggtc tcgtcaaaag cgcggtcgat atcctcctga acgctgatgt 3122221 ccccttttac aaagcgaaaa cggctgtttt gctttaattt ttccatttcc tccgggtggc 3122281 tggcgtacgt cagtttatct aaaacggtaa tgcgcgcatc cgtttccctc agcatgagct 3122341 ttgtaaacgt gagcccgatg aagccggccc cgcctgtaat taaatatgat tttgccatca 3122401 cttttcgtcc tgtcctttcc gtaaagcctg gtgtacaagc tgggaagcga gataaagcga 3122461 ttcgtgagtt ccggcatcta cccaccagcc tgataacaca tcatacgtaa gctggctgtt 3122521 ttcgatgtat agattattca catcggtgat ttccagctcg ccgcgctttg atggtgatat 3122581 ttgttcaata tatgaaaaca cctctgcatc atacatataa atgccggtaa cacaaaggtt 3122641 ggtcggtggc tgttcgggct tttcgatgat ggaacgaatc cgcttgtttt tctcatcaat 3122701 ctcagcaatc ccgaaacgtt ccgggtcatc aacttctttc agaagcactt ttgctccttt 3122761 cccctgctgt tcaaagcgtt ctgtataagg ctttaatgaa tcttcaaata tattatcacc 3122821 taataataaa atgaaagact cttttttcgt aaagcgcttt gcataagaca gcccatccga 3122881 aatgcccgat gctgccggct gtacttgata agtgatagta acgccaagct cttccccgtt 3122941 cccaagcagt ttgtaaaatt gcggcatatg ctccttttgg ctgatgagta aaatgtcttt 3123001 tattccggct tcctgcagct tcataatcga ccagtatatc atcggatacg ggcctacagg 3123061 aagcaaatgc ttgttgacgg ctttcgttaa gggcataagg cgtgagccgt ttcctccggc 3123121 taaaataaca cctttcacat taacacttcc ttacatgcat ttttatatct cttgttcata 3123181 taaatcttga agaatagctg ttacccgtat aatgcctttg ccatccacga gcggccttcc 3123241 tcccttgtgc aaagaaaggc gaagaggata gctgctcata atgcgtgaca tctgatagat 3123301 gagtgtttca tccggtacaa gctcacccaa tccaagatca agagcggcgc cttggtcagc 3123361 aaatgttttg gctgtagccg tttgatgctc aacctgagaa agaacaaggc acggcacgcc 3123421 gatgcaaatg gcttcatata gagagatgcc gccagcgaca atggctgcgt ccgcttgttt 3123481 catcaaacct gccatatcat ttgtctgttc gatcatcttg tactgcggct tcttttcgat 3123541 ccgccttcgg actgcctctt gatgcggtga agcgctcccc atcacaaaca tcatgttttt 3123601 gtcttttatg tcggggactt gatcagcggc agccagcact ttaaaaataa gctgcttcgg 3123661 atcacttcct cctaatgcaa caaggatatt gcggcagtct ttcttaagtg tgtaatcctc 3123721 tcttgcggcc tgaaaggcgg ggtgaagaat aagatagtcc ggaccttcat agatgcgtgt 3123781 gtttccctga acgtacaccc tgcttctgat gtcaccgtaa attccgttaa tgactgcgtc 3123841 actatattga atcgatttac cgtttttctc ttcaaaaaga acaattttcg catctgtctc 3123901 cgtctttatt ttctttaaca gctctgcagg cgcgcctaga atatcaaaca aaagcaaatc 3123961 aagcttcttg ctttttattt cccggagaat aaattcgtgc tgctgcagct ccggctttac 3124021 gatgacctgc caatgctctt catgaagaaa cgcttcagaa tcctgattcg tataaaacgt 3124081 aatcaagcat cgctgtttga gcccctccgc aagcctcttc atccggacaa catggcccat 3124141 tcccttttca tagccgccgt ctgcgaagat cccaacatgc atggctagtc agcctctcgt 3124201 tcggttgccg catcggggtt ccggttcaga agggtgataa gctctgaggc ggatacatcg 3124261 gggcgctcgc ctgctttttg atagagggcc tttatcgatt catagtcttc ctttgtatca 3124321 atggtcagcc gatattgagg ggcgcgaaat cgttccggcg cctctaaaaa ctgaacacga 3124381 taaagagctg gatgattcct tatatataac gtgacatgct cctgatattg atcctccaaa 3124441 gcctgaatac ggctgatgtc aattaacagg ttggcgttga ccacttcgcc gcaaatccct 3124501 aatggggcat tcaggatata cgtataatcc gagccttgat caaaatgcgc ctgaatcatt 3124561 acatcgagca gctcaggatc gacaaacgga ttatcacctg ttaaccggat gatgactgac 3124621 ggtttaacag cttctatgac cttcacaaac ctatcgagga cacgttcttc gctcccgcgg 3124681 aaaacacgaa agccttgttt gatacagtgc gcctctaata tgtcgtcagt ttctttgtca 3124741 gacgtggcga tgacaagatt atcccgatcc ttttggtaaa acgcgctttg ccggacacgg 3124801 tgaacgagaa tatcaagtaa acgattcgat ccgagcggcc gaagcacttt tcccggaagc 3124861 cttgttgaac ccattcttgc ttgaatgata aagagaatat cattcatgaa acgggctgtc 3124921 cttcagtaaa atgtcatccc agacaatgcc tgtgtcggct ggaatgtctc ttacagcccg 3124981 aacaccgctg gtcagcagtt caaaaaatct cgggtgcagc ccctgcggct tttgtccggg 3125041 ccgaagcact gcgatattgt cttcactaaa ggcttcacct ttttgaatcg gagctgttgt 3125101 aaaaatgcct ctgtatgcaa agtttctgat ttctccttcg atggcggtcg ttgttttgta 3125161 tgaactgcca agcagttttt cagagaccgg ctttgtgatc ccctgtttca gctcagcttc 3125221 cgttttcctg atgccatcga ccatttcttt caattcatcc ggatttaatg caaacgagtg 3125281 gtcagcaccc ggcagatttt tatcgatcgt aaaatgcttt tctatcagtt ttgctccgag 3125341 ccgaaccgcg gcacacggcg cttctgtcgg atgctcgcta tgatcggaga agccgattac 3125401 cgcctcagga aaagcggcgg caagcatcgg aatgacgctg aggttgctgt actccggcgg 3125461 tgctgggtat ttcgccacac aatgcattat ggcaatttga ttgtttccct ctgccctgat 3125521 ggtgcgccaa gcttcgtgaa catcagagat ttcagctccg gctgtcgaga aaatcatcgg 3125581 cctgttcagc cgggcgacat atttaagcag cgggagatgg ttaatttcat aggatgcgat 3125641 tttaaaagcg ctcggcgagg tagactgaag cagatcagct gacccctcgt cacataccgt 3125701 acttaaaaag atcacctgct tttcgcggca gtaatccaat agcggtaaaa tccactcagc 3125761 aggcatttcc atagattgaa ccaaagaaaa aatagagacg tccttgcccg ctgccgtctt 3125821 gtacaaacca ggatctttct ggtacatcct atcagcttgg aacatttgaa atttcacggc 3125881 atccgctccc gcttccgccg cggcgtctat cagcgcaaaa gcctgatcaa gcttcccgtc 3125941 atgattaatc cccgcctcag caataataaa aacaggagcg tctttgccta cagttttatt 3126001 cgcgatctga aacgctgcca ttatttcgcc tccttgcccg gccaaatatg ataatagtaa 3126061 tacgattgtt cagcggtgaa gcccattcgt tcataaaggc ggatcgccct tacattgtga 3126121 agctgcgtcc ccgctgttac cgttctatgc ttctgggtct ccggttgttc tatgagattc 3126181 gccaataaat gaaacgcaat acgtttccct tcaaatcccg gctttacagc catcaaatcg 3126241 agaatgcact catcatctct tgataagccc tgaagatagc cgatgacctc gccattgtgt 3126301 ttagcgacaa tattgaccgc cgcccttcca ttcagattgt ttcgtgtcca ctcctgaaat 3126361 atttcgtttg ctgcatcgcg gctgagatga ggatcctgaa aatatctgct ttttgtaaac 3126421 gagtctcggg ccagctcaca tatcgcttct gtgtctccgg gctcaggcgg gcccagttca 3126481 aaaaatggcg gtgttttgtc ataaaaagac ggaggcatcg ccagcttcag caaactcccg 3126541 acaaagtaag aggatggctg ctgttgtatc acatgcgcgg ctccgatatc ttcagccgga 3126601 acacggacaa agataaaatc cgtttcatcc atttggcgta cagtataaaa agcttcaaac 3126661 agcctcttta gctgcccggt actatttgcc gcaagaagtt tgacgttcat gactttcttc 3126721 tgaagcacct tgctttccca caaagaatct tcgtaaagca atacgccttg gagcctgctg 3126781 ttttcaaaaa ggccgaggga aaattgatac ggaacatcca atgtaagctt tctgctttgg 3126841 agaaattcct caattgcctc tttggagaca ttttctttta ccgtatacac ttaatcagcc 3126901 ccttttacga tatcccgcac agcttcaatg acatcatcta catcatcgtc agacattgat 3126961 ggatagagcg ggagagaaag ggttcgttta tagtaattca tggcattcgg aaagtccgct 3127021 tccttatatc caaattgctt ttgataatac ggatgaatgt gtactggaat aaaatgaacg 3127081 ctagtgccga tattgtattc atcctttaaa gccgtaatca tttcgctgcg cgtaaccccg 3127141 gccttttttt catcaacttg cagaacatat agatgccagg cgtgcctgcc gtcatcatgg 3127201 acaaacggcg tgatcagccc aggaatctgc tgaaaagcgg tttgatagcg gccggcaatc 3127261 tcttctctcc gtttctgcat atcatccagc cgtttcagct gatgaagtcc gagggccgcc 3127321 tgcaaatcaa acatattcat cttatagccg ggcgattcga cttcatagta ccagctgcca 3127381 tttgaagaat aacggttcca tgcggcttta ctcatgccgt gaaggcttag cacccgtatc 3127441 ttatcggcaa gctcctcatc atcagtcgtc agcatgccgc cttcccctgt cgcgaggttt 3127501 ttggtggcgt aaaagctgaa tgccgttgca tccccgatag aaccgatcat tctttgctta 3127561 taagtcgtat ataccgcatg tgccgcatcc tccagcacga ataaaccatg attttgggca 3127621 acagccaata ttgcatccat atcgcaggac tgcccgccaa agtggacggg cacaactgct 3127681 ttcgttcgcg gtgtgacggc cgcctcaagc tttaccgggt caatattgag cgtgttttcg 3127741 tcaatatccg caaacacagg cgtcgctccc gtatgaataa tcgtattggc ggtcgagctg 3127801 aacgtaagcg gagaggtaat gacctcgtcc ccgggcccaa tcccttttgc tttcaaagcc 3127861 aaaaataaag ctgcggtaca tgaattcacc gccacggcgt gcttcgcccc gacaaacgcg 3127921 gcaaactctt tttcaaactg ctgaaccttc gggcctttag agagccatcc cgattcaagc 3127981 gtttctgtaa cctcctgaat ttcttcctta ccgattaacg gcaatgagta agggagaaaa 3128041 tgatttctct tttgcaccat ttctttgcgc tcctatcatt ttattcagta tcttcccgcc 3128101 tgtaatcaac ccctgttttg gctttcagtt ccgcaaataa agcatttgtt gattctgcca 3128161 ccggataatt agccgctatg aatgccaggc gcgcctcttc tgctttttga tgcacgtcgg 3128221 gacttcgaag aacctcaacc aaggtgtgcg ccagttcatc cggctggtca aacataaaat 3128281 cgccaagaga ctcataatac ggatacgagc gatttccgga cgattttcct atcagcacag 3128341 gcttttgaaa cagcatggct tcaagaccga ctgtcgaggt ttgcgtcact gcggcatcaa 3128401 catacggcag caaatcataa agctccagct cctttttgat gactctgcat gcttgatgtt 3128461 ttttcgccgc ctcgtgatac agatcaagct tgttttttcc gatttcccac gggtggggtt 3128521 tgataatgat ttgcagctgc ttctgatcag aaagcccctg cagcacaccg gaataaaagt 3128581 cttctgaaaa gggctgagtg gcaatgagca caattttttt agtcggctga aaagcaagtt 3128641 ttcgatagaa tatggacata tccataggcg ttctgttaaa aatctgatcg aagcggggat 3128701 gtcccgttac gagaatctgc tcgggtttac agccttttcg tatgaaccac tctgcttcat 3128761 acgcaccaaa aacagcttga taggttgtaa aaacaggaat gaaggcttca tctcccatca 3128821 atgcgccatg ctgaagacaa atgctgacgg ccccttttct ttgacacatg agagcgagca 3128881 ccctgctgta aatgtcttct gccgttccga caataacagc tgaaatcttt tcctgttcaa 3128941 acagcgcatc aactgtatca atggcctcta taaataaagg aatatctttg aaaagccggt 3129001 cgcgaaacgc ttgatcacca aatgccgggt gatcatcata aggggcgaga agcgaacagg 3129061 ctgtttcgag atactgcttc gaatcgcctt tttggcatga atccgcaatc tcccgcttgc 3129121 taattacagg cagatcacaa taatgcggca aactccatct ggccaaaaca gccgtttttt 3129181 caggatcaaa ttgatagtaa ttttcgtttg aaaaacgcag gtaatcaaag tgcaaaatga 3129241 ctttcccttt aacaggttcg tcatttgttt taacgatgtt ttggattctt tcttcaaaaa 3129301 acggctgaat ctgtccctca tcgatatgct gatccaccga tccgaataat tccggttctt 3129361 cttccatcat caccctcagt tcagggctga tgtattgata aaaattactg ataagcccaa 3129421 gcggaatccc tttgtagcga agtttgtcaa aaagctccac gtacttccgg tacagcaccc 3129481 aataattgct taaataggcc gacaagctct caccccattc caagcttttt taatgattca 3129541 cgcagctctc ggcaatttcg ctgcggagga aggttcctga caaattcatt tttttctaat 3129601 tcaaacagct gaaagtgaat cgattggtcg gtaatataat tcaggtccag ctcctcatcc 3129661 agtgggtaaa acggataaaa atgattgact ctccaaaaga accgggcatc tcctatacgg 3129721 taaaacgccg ggctttcatc ccaataggag ccaaacttct cctttacctt ctcaagcacc 3129781 gaatacctgt gcatcaccga gcaatgatca attgcgcacg gcgcgttcca tgtcacttga 3129841 gcggcaggcc tgacagtttc ttttacaatg tcacgattct cgtttaaatg ataggttttg 3129901 gaggctgagt aaatcacagc cttttcagga tgggtatcga gctcccgcac cattttcagg 3129961 aggcggtccg gcatatagat gttgtcatcc gtcgcatagg tgatatattc accctccgcc 3130021 atctcaatcg cctgattgat cagtgccgcg tatctcgttt tttctgttct ttccttcact 3130081 ccagatatat cgctttgata aaaacgcact cggttatcat tcaaaaaagg acggattaca 3130141 ttcagcgtct cttcattgga gttgtcatcc ataataaaca attcaaaatc tgaaaacgtt 3130201 tgtgagagta tgctagaaat ggactttgcc acataatcgc ttttgttata gctcgtcata 3130261 atgactgata ctttaggcaa atcctacacc tccttcttgg aacttcacac ctgaaactat 3130321 cgttatctta tgttgcttat gctcaagttg cgctagggat acaaaccaat atgcgaaaag 3130381 tttgtgtatg tttctgaaaa acagcggctg cccagagcga aatctgatcg gtccgctgtt 3130441 ctttttcagc ataatccaag catcagcctc ataaggtgaa agagataaaa atcgcaccag 3130501 cgactaagat cgttttccat cggaggtgag tcatcgcgga gcgttcacct atacatccag 3130561 aacatgtttt gaatggtttt cataaaaagg aggaacgata tgaaaccgaa aaaaaatcaa 3130621 tatcagcaaa tgcaggcatt tgataatatg caggggtatc agcctcagtt tggcgccaac 3130681 ccgtacccgc agcaaggcca aggctcacaa atgcagacaa tggggatgca gccaatgatg 3130741 ccaatgcagc agggacagca aggacaacaa ggacagcagg gatttggatt cccgggccag 3130801 cagcagggcg gcggttttca aattccatcg gggcctacac cgtcaggacc gggccaaagc 3130861 gttcccggca tgctgcctgt tgaggaatct tacatcgaga atattttgcg cctgaatcgg 3130921 ggaaaaacgg ccaccattta tatgacattt gaaaacagca aggaatgggg ctcgaagatt 3130981 tttcgcggcg tcatcgaagc tgcgggccgg gatcacatta ttatcagcga cccgaaatca 3131041 ggaacacgct acctgctcct gacaatctac ctcgattaca ttacatttga tgaagaaatt 3131101 gcttatacgt atccatattc catggcgtcc tattcgccaa gataagaaaa aagccaatca 3131161 ctcatatgat gaggattggc ttttttgttt atagatattt gacggctgcg acaacgatca 3131221 taatccaaga aataataaac gccacaccgc cgagcggggt gatcgctcca agaatggaga 3131281 tttgcgtcac acttagaata tataagcttc cggaaaacag cacaattccc gcaaacatca 3131341 gccagccggc tgtcgtgaca ctgcctatgc cggataattt atcagccaga aacgcgacaa 3131401 cgaataaccc aagggcgtga tacatatgat actgcacgcc tgtgtgccaa acctgaagat 3131461 acttatcagg tattttccct tctaatccgt gagcgccgaa tgctccgagt cccacggcaa 3131521 gcagggcgtt aatggcccct aatatgataa aaactttcat ctatctctcc cgccttttcg 3131581 ttaaactcat atcatttatc ttatcgcacc tgcaccaaaa ttcaatgttt gttctccgtt 3131641 gacacgagat tgtcggattt tctcctgcgc caaagctgga actggtcagc tgctattgca 3131701 gcaagcgtcc ctaatacgag cccgttgctt aatagagaaa taaataccgg atgcaatccc 3131761 tttaacgcag tttcaggaac aaacatgata ccgacccctg tcagcagtga gataccgatg 3131821 atagacctca ccctttttga ttcttctttc tcatatgaat caaattcggc aaaggccaga 3131881 ccgcccattg cggagaacac aacaaaattc accgcaaatc caacgggtga cggcaggctc 3131941 gcaaacgtat tcataaaaaa cgggatcacg ctgatcacga taaccagaat actgccgagc 3132001 ataaacggtt ttttagaagg catcttggtc gtttcaataa aacctgcggc tcccgaaatc 3132061 ggaacaggcg caatagctcc cgtcaaaccg ctaagcagat ggctgaatga agctgcaaaa 3132121 ccggcatggc gttcatgatg ctttccatca ggctgtttgc tgaatttttt catggcgatg 3132181 tccacgacct tcatgctcgc cagcatattc acgatcagca agatggtaat aaaaatagaa 3132241 gtgatgatca ggccgctgtt aaataacggg gtcccaaaag gaaacaggga aggcagctga 3132301 aacagccggt ccggcatttc aatcggcttt gcggctccgg cagccgcaaa cagcacccac 3132361 ccgccgaaca aggctaataa aatagaatat tgcttaaaaa acatgatgtt cgaatttgtc 3132421 attataaaag cggcagcgat cacaacaagc gccaggccaa atacaagacc gtccaccccg 3132481 tcctgtcgat aaccgattcc gagaattcct tttataatgg gctgactcag ctgcatgaca 3132541 agaagcaata aatagacgcc cgttacaacc ggagtaaaca attttgcaag tctgtcaatg 3132601 accttgaaaa cacttaacaa aaagaaacat acagcgctta caagaagagc tccctgcaaa 3132661 ccccgcagtg tgtctccata tgtcgcaaac acagttcccg tcagccctgc gtaaatcgta 3132721 tacactcccc accacaagcc ggctgggctt tcattgatcg gcagtctgtg gcctttcaaa 3132781 cactgaatga cggcggcaat tcccagtaca aaaaaagtgc tttgaatcaa tcttgcagaa 3132841 tctgagtgat ccagatgaaa cgactgggca accgccaccg gaacaacaat cgccgcagca 3132901 ataataaacg ctgtccattg cagcgcgcca agaaccaatt tcacgtaagc tcaacctctc 3132961 tctttaaaaa tcaaataaag actctccgtt tccatcctct tcctgcttct ctttttcttg 3133021 ctttcgatat ttgtttaatc ccgcgctccc catcattttt tccatcatca gctggtctgt 3133081 cgatggcggc gcggcgggac ttggcgtaac gctcggctgt atgcggggcg cgctcgcgtt 3133141 ctccggctga tcaagcacga catcacacag agaacggaca accgctacat aacgcttcag 3133201 ctcctcatcc cgttcagccg tttttgcttt ttttagctct tcttccatct tttgaatcaa 3133261 agcagatata tgaatgttca tgaagcaccc tccaaaaaaa taaatgttgt cttcctgcat 3133321 tttatcaaat tcctgctgaa aacgcagata tgagtttgtt attttttctg acaaaccttg 3133381 cgcgattgac aagcagaaga gatttttcac ataataaatc accatacctt acaaaaagga 3133441 gaaacggaat gaacagcatc ccctctatca tcagcaagca taaagcctat tttgcggcgg 3133501 gacatacgag accgcttgaa tcgagactga acattttgcg aaagctgaaa caagccgtca 3133561 gaactcatga agccgatctc atagccgctc tctaccagga tctccataaa tccgagcaag 3133621 aagcatactc aacagaaatc ggaatcgtct tggaggaaat cagctttgtc atgaaacggc 3133681 tgagaaaatg gtccaagccg aaacgagtca aaacgccgtt gactcatcta ggctccaaaa 3133741 gcatcatcat ccctgagccg tatggaaccg ttttggtgat tgcgccttgg aactatccct 3133801 tgcagctggc gctttctccg ttgattggcg ccattgcggc ggggaacacg gtcgttctca 3133861 agccatcaga atatacgccg gctgtttctg ctattctttc caaactcatc agcagcgttt 3133921 ttccaactga ttatgtcgct atggcagaag gcgggcccga tgtcagcaca gcattattac 3133981 agcagccctt tgactacatt ttctttaccg gcagtgtagc tgtaggaaaa atcgtcatgg 3134041 aggccgccgc caaacaatta attcccgtaa ccttggagct cggcggcaaa agtccctgca 3134101 tcgtccataa agatgctgac attcagcttg ccgccaaacg catcgtcttc gggaaattta 3134161 caaatgcggg acaaacctgc atcgcaccgg attatttatt tgtccacgag gacatcaaaa 3134221 cgaagctcac agaagaaatg aagcgtgcga tcagagaatt ttacggccct cagccggaac 3134281 ggaatccaca gtacggcaaa atcgtcagtg agcgccacta tcagcggctg ctcagctttc 3134341 tgaatgatgg catcccgctc acaggcggac aatctgatcc caatcatcac aaaattgcgc 3134401 cgaccattct cgaacaagtg agagatgact ctccagtgat gcaggaggag attttcgggc 3134461 cgattcttcc gctctttaca taccgcaata tcggggaagt cattgagaaa gtccaatcgc 3134521 gccctaagcc gctcgccctg tatctcttca ccacaaacaa agaaattgag cgcgctgttt 3134581 taggaaatct gtcgtttggc gggggctgtg tcaatgatac gttaatgcat gttgcgacgc 3134641 cgtatttgcc attcggcggc gtcggggaaa gcggcatcgg cagctatcac gggtttgaca 3134701 gttttaacac attcacgcac aaaaaaagcg tcgtcaaaca aacgaaccgt ttcgacttcg 3134761 catttcgtta tccttcctcc aaaaacgggc tgcgaatgat tcgaaaaata ctcaaataaa 3134821 aaagcgcaga tcacctgcgc tttttacaaa tccttaatac accaatcaat cggcgcctct 3134881 cccattttct ccaaataggc attcgcccgg gaaaacggtc tgctcccgaa aaatccgttt 3134941 ctcgcagaaa acgggctggg atgcgtcgat tcaatgataa aatgcttgga ggtgtcgatc 3135001 cgttcttttt tcatttgagc atgccgtccc cacaaaataa agataaccgg ccgctctctt 3135061 tcactcagca cgtcaataat tcggtccgtc agtcgctccc agccttttcc cttatgggaa 3135121 ttcgcctgtc cgcgccttac tgtcagcaca gtattcagca aaagaacgcc ttgctttgcc 3135181 cagctcacaa gcgacccgtg attcgggatg ctgcacccga tgtcctgctg cagctcaaga 3135241 aagatatttt ttaacgaagg cggctgcttt acaccgggct tgacagagaa gcttaaacct 3135301 tgagcctgtc ccggcccgtg atacggatct tgacccaaaa tgacgacctt gacatcatca 3135361 tatgatgtat aatgcagcgc gttgaaaata tcccggctgt ccggataaat cgtttgctcc 3135421 gcgtattccc tcttcagcat ctctctgagc tcttgataat acggtttctc aaactcttcc 3135481 tttagctgat tccaccagct gtcttgtaaa agctgtttca agattcaggc ctccttacga 3135541 acgatgaagt ctggaataga caggctcgcc atcccaaacc atttcacttt ttgcttcccg 3135601 cctcttcatc tcaggctctt caagcaggac ggcaaagttt ttcgtcggca gctccccgag 3135661 tccgtgcttt tcacttaaac gatccaaata ttgcttccgc ttggcgccaa ggtcagcaga 3135721 ctgattgtct cccgcgtcac tgaaggcata aatcacgctg gcgcaaggga cacgcttcac 3135781 ccggtaatcc ttggccgcgc gcaaataaaa atcccagtcc cagtaattgt gcacatcagc 3135841 atcgaaatac ccgatttcat catgcagaaa acgtctgtac atgctgcccg acggcacgta 3135901 tgtagaaaac actctcatat cctcatagtc agcggtataa gcaaacaatt tccgtgacac 3135961 tggatacctt gttccgtttt tctcttcaaa cgaaactatt tccgcatcag aatgaacgaa 3136021 gtctgccgtt tctatttcct ttgccatttt ctcgatatgc cctggcgtaa agaaatcatc 3136081 gtcatcacac agcataatgc aatccccaga cgcctctttt acaccggcat ttctcgcagc 3136141 cacatgcccc gagttctttt ctaaattgat gacagcaatc ggcagctccg gataaagtgc 3136201 tttgaccggc acgaccgatt ccccggcatc attcacaata ataatttcat acggcatcaa 3136261 ggtctggcgg gaaatcgact ccaaaagctc acacaaagcc ggaatccgat tataggtcac 3136321 aattacgata gaaatcttca tgatgctctc cttctcattt tcatagtcat gtactattaa 3136381 aacatatatt ggacgggaga tcagtgggaa tatcctactg aaacggcata ctacaatgat 3136441 agaaacagca aagtggctcc gatcagaagc accatgatca gcatcagatc tccaaagaca 3136501 tgaaagatat ctttcatgcg gacgccattc ggaaggataa gacgccacag cttagattga 3136561 tagaccggca gcagcaccag tgcataagaa agacacaaaa atgtaaaagc cggcggcaca 3136621 aaagcacagc ctgcatcgtc ccaattcatc atgatgtctt tcatactaga tccatccaat 3136681 aaaaacaaag atatcatgag ggctagcaac acaaaggacc ccaattgaac ctcaaacagg 3136741 cgcattttct ggttatatgc aaatcggacc gcccaaaacc agacataagc atatgaacat 3136801 agcagcgtaa gaatggcacc tgctgtaaag acgacatcag gcagccgatc aagcagaaaa 3136861 acaaaaggca agctggctgc catagccaag agcatgcagc caccagtaaa caaaaatact 3136921 gccccatgag ctacaaaacc atataaacaa gagctaatcc tcacgacata cacctccttt 3136981 acatagaaat tctatgtata tacctaaaaa atcagacaag ctgacgcctg ccaatataac 3137041 agcccattcg gccaaataac ggaaataaca gcgttgcaaa agcacaagtt ccaacaaacc 3137101 aaggtgtcaa caaggattga aacagcgcag caggaattac attgaataga aaaacaagca 3137161 taaaaatgac gtttggcacc attgagatca gaatcgtatg tagaacaagc ttttctccgc 3137221 gttttccaaa ctccttcacg ccttgatacc caatcagcac ccagtagatc atatatgcag 3137281 ctaagatcag ccaaacagaa acagaaatgc ctttccatac tgcttgaaca aacggtgatt 3137341 caagccatac atgcattatt gtaatcgcaa tgccgacagc gaatagggca ctgttacaga 3137401 aaagatggaa catcaaaaac gcacgaaacg ttactggctg tattttctta aacgaagaaa 3137461 caatgtcagt tggtgttcca aacgcctgca ataaagtctg catagcttcc tcctcactct 3137521 ttccttcctg aaaagagcga aacagatgat gttcaatatg gctctcaatc tcttctatca 3137581 tcgcctcacc ctcaggaagc cctttaagcc cgcttttgat ttcggataca tatgtttctt 3137641 tatccatttt gtccgctcca cttcagtatt cggtccatca tggctgaaaa tacgctccat 3137701 tccttcgtgc gttccgccag cacttctttg ccctcgtctg taatccggta atatttgcgg 3137761 tccggtcctt tctcctgctt ctcccagtag gaagaaatat acccttggcg ttcaagcttg 3137821 tgaagagaag gatacaaggt cccttctttc atctgcagtt catttccgct gcggcttccc 3137881 atttctttta caagctcata gccgtacatc ggccgctcgt tcagaagcgt caataccaat 3137941 ataaccgtgc ttcccttaac cagctcacga tttaacatct caaaacccct acctagtttt 3138001 cttatgtagc attttacgaa agcccgttga gattgtcaaa tgattcctat agatcttcta 3138061 tattgtgata cagagaaaat ctaactataa tgaaagacaa aacatgatgg aggttcaaga 3138121 catgtctatg cataaagcac tcaccattgc cggctcagat tccagcggcg gtgctgggat 3138181 tcaagctgat ttaaaaacat ttcaagaaaa aaacgtatac gggatgaccg ccttaacggt 3138241 gatcgttgcg atggacccaa acaacagctg gaaccatcag gtattcccga tcgatactga 3138301 tacaatccgc gcccagcttg caacaattac ggacggcatc ggcgtggacg ccatgaaaac 3138361 aggaatgctg ccaaccgttg acattatcga gcttgcggca aaaacgatca aagaaaaaca 3138421 attaaaaaat gtggtaattg acccggttat ggtttgcaaa ggtgctaatg aagtccttta 3138481 tccggagcac gcccaagccc tgcgtgagca attggctccg ctagccactg tcattacgcc 3138541 aaacttgttt gaagccagcc agctcagcgg catggatgaa ctaaaaacag ttgacgatat 3138601 gatcgaagcc gcgaaaaaaa ttcacgcact cggcgctcaa tatgtcgtca ttacaggcgg 3138661 aggcaaactc aaacacgaga aagccgttga tgttctctat gacggagaaa cagcggaagt 3138721 ccttgaaagc gaaatgatcg atacgcctta tacacatggc gcaggctgta cattctcagc 3138781 agccgtgaca gcggagcttg ccaaaggtgc ggaagtcaaa gaagccattt acgcagcgaa 3138841 agaattcatc acagcggcca ttaaagaatc cttcccgcta aaccagtatg ttggtcctac 3138901 gaagcattct gcactgcgcc tgaatcaaca atcataaaaa aaggggctgc cttacagaga 3138961 ggcagccctt tttaaatcac cgaagacttt tcacagaaaa aactgccgat cccatcggca 3139021 gcctgtttat ttgattttta aattgtttgc agatttcctc aaaaatgttt ctatcgactg 3139081 aacaaaaagt gcatattcct tcatttgttc atatgcccgc gtgagaattt ccgccgtttc 3139141 actgtgcggc gttgttccgc caagcatttt tttcagctga agcagcacat ccttatattc 3139201 ttctcgctta tcttcaactt ggttagcagc cttttccaaa cattccggtg ttatcttctg 3139261 ttcatgtata ttcaagaaaa caactccttt tacagaaaaa aatagtaggt tatcgttgaa 3139321 gaatagcaca gatggctcag atttcacata agaaaataga aggattttct acataagtgt 3139381 ccaaattccg acattcattt cagatttccc ggtcgcactg gctgttactt catgatttcc 3139441 cgggaaagga aaatatcttg cactcaagac ctcttctccg ttattgataa agatttccac 3139501 agatgacgcg tcgagaaaca tgtgtacggt atgcaaatcc ttgatgcggc aatgtctcgc 3139561 ttctgttctt tttccgtcaa agctctttcg ttccagcgta acaatcccct cgtctttatg 3139621 gaaggaaaac gtagccgttc cgcggatact gattgaaaag ccagactccg tatgaatgtc 3139681 ttccagtaga atctcagttc tttcaggttt ttccactgga agcgcaccag atgatccatg 3139741 catgttgatg tgtatttttt tctcatttct gcgcatggct tttagctcag gcagcggctg 3139801 ctgaatcagc ttctgtcctg aaagcgtcag ctgtctcggc agcgtcatgc agtgaatcca 3139861 gtggcagtca atggtcggat gggacccttc atcctgatca ggcaccgcca tccatgcaaa 3139921 taaaatccgc cttccctgat cgtcttcaag tgtttgcggc gcgtaaaaat caaaaccttg 3139981 atcaagctcc gtaaattcac catgcttcag ttcaggcttg ttataatcga ggcggccgac 3140041 aaaataacct gattgatata cgttctgata acggaaaccg tcagcctcaa gcccttgagg 3140101 cgaaacaatc agcacatccg atccttgaag ggaaaacaaa tcagggcatt cccacatgta 3140161 tccaaaatcg tccagcccgt tgaagcccgc gccggttatc gggccaagaa atctccactc 3140221 tgtcaggtta tcagaagcaa acaacacagc ctgccctttc aaattctctg tttgcgcacc 3140281 aatcaccata taccatgtgc cttcatgctc ccataccttc ggatcgcgaa aatgcgccgt 3140341 atatccttcc ggaaggcggg cgacgacacc ctttttctca aaggacagcc cgtcgtcaga 3140401 aacagcaagg cattgatacg tttcccgatt tccatcctga tccctgacat ttcctgtgta 3140461 aaaaagatag agccgatcgt ctttcgtgac agcgctgccc gagtagcagc cgtttttatc 3140521 aaaccaatca ctcggagcca gcgcaatctc ttcccgcttc caattcacaa catcctgtgt 3140581 cgtataatgc ccccaaaatt ttgcgccgtg ccccgtctga aacggctgcc actgaaagaa 3140641 tacatgatag ctgcccttcc aataaatcac gccattcggg tcattcagca gcccaaccgg 3140701 cggcatgata tgaaaatgct ggcggtgcgg atcgctgtta gcgatgggct cttttttctc 3140761 cacttcttca taagcccggc gacgaagctc ctggtcatgt gctgtcattt tttcctctcc 3140821 tcatcctcat taatcttcat gacaaatgct gcaatgaacg ctgacactgc cgcaatcgcc 3140881 atgccaatca gatagtgaat caagttgctg aagccaaacg gagccgcaat ggcgatcatc 3140941 ggaattcccg ttaacccgta agcgtttgca gctacatgtg taaagacgac atatgcccca 3141001 cccaatgcgc ctccgatcat cgcggcgata aacggttttc ggtagcgcag attgactccg 3141061 aatatgacgg gctcagtaat gccgagaaaa gcggaaaatg ctgccggaag cgcgatttct 3141121 tttgtctttg cctttttcgc cataaagaag acggcaagac ctgccccgcc ctgtgcgaca 3141181 ttcgccattg accagatcgg cagcaagtag tttttgccta tatctgcaat tagccctgcc 3141241 tcaatcgcat ggaagctgtg atgaacgcct gtcagcacga tgagtgaata cgtgcccccg 3141301 aaaatcagac ctgcgacaaa accggcatgg tcatatacat aagttaaagc aaccgtaatg 3141361 ccggagccaa gcgctctgcc tagagggcca atcgcgataa aagcaacaaa cccggtgaca 3141421 atcacagtaa caaatggtgt aacaagcaaa tccaccgcat gtggaaccac ttttctcgtc 3141481 catttctcta ccttgctcat cacatacacc gcaagcagga cagggataac agttccctgg 3141541 tagccgagaa gagcgatatc aaatccgaaa agatgcatgt aatcaggtgt cgcttccgcc 3141601 aatccccatg gatttaaaag attcggatga atcatgattc ccccgatgac cgctcccaag 3141661 tatggattgc tgccaaactc ttttgaagcg ctgaccccga ttagaatcgg caagaaaatg 3141721 aatgctgcac ttgaaaacat atcaagcagc tgcaaaagcg cagaatcctt gctcatccaa 3141781 tgaaacgcat tgatcatacc cagcaatccc attaataggc cgctggctac aatagctggg 3141841 atgattggaa caaaaatatt agaaagcgtt ttcgcaaatc tcgcagcggg attcagcttt 3141901 tcttttgccg catcctgatg attgacgtgt tcttcacgct cgatatcagc ttctttagaa 3141961 aaggcatcga atactttatt cacaaggcct gttccgaaaa tgatctggta ctggccagag 3142021 ctgctgaaag cccctttaac gccatcaagc tcttctactt gtgcttgatc tatctttgat 3142081 tcatctttca tcactaaacg cagtcttgtt gcacaatgag ccgcgctgat aatattttct 3142141 ttccctccga gaagctcaat gaggcgtttt gcagtctctt tgtaatccat ctatttctcc 3142201 cccttttatt taaacaaaaa agacctaaaa ttcgccaacg aataaaggac acagcgatcc 3142261 tttttcattt acgcaaattt taggtcttgc ctgctttacc agtcacaatc ccgcttattc 3142321 agattaagaa tacgctttca tcataaatca tgatagcgtt ttcgtcaact atttttttag 3142381 ttaaatagtt tgatataaca tgtagacaaa aattcgtaaa aattaattgt gaaatacttc 3142441 acaatatcgt gctatactat gctcaatcat gaaagaaagc aggaaaagac aatggaaact 3142501 caagcattac aaaaggttga acagtatgct ttgaaaaaac aaaacatatt cgcttcaagc 3142561 aaaatccgtt atgtgcttcg gtccattttg gccagtatat ttattggttt tggcattaca 3142621 gccgcaagca aaacaggcag ctatttcttt atggctgatt ctccgtttgc ctttccggca 3142681 gccgctgtca ctttcggggc cgctattctg atgattgctt acggaggcgg agatttattt 3142741 accggcaaca ccttttattt cacctatacc gcgctccgga aaaaaatcag ctggcgcgac 3142801 accctatact tgtggatgtc aagctatgcc ggcaatttaa tcggcgccat tctgtttgcc 3142861 atcctgatca gcgcgacggg actttttgag gagccttctg ttcattcctt tttgattcat 3142921 ttggcagagc acaaaatgga gccgccggct tccgaattgt ttttcagagg aatgctgtgc 3142981 aattggcttg tgtgcctcgc ctttttcatt ccaatgtctc tcaaagggga aggagcaaag 3143041 ctttttacca tgatgctttt cgttttctgc ttctttattt ccggctttga acacagcatt 3143101 gccaatatgt gcacattcgc catctcgctt ttgatcgagc accctgatac agtgacactg 3143161 atgggagcag tcagaaactt aatccccgtt acgctcggca atctgaccgc gggaatagtt 3143221 atgatgggct ggatgtacta cacactgaat cctgatcaat aaaaaaactt ccagagatca 3143281 ctccctgcaa gtcaaagcgg ttattccgag agatcttgaa gacgctggac atgcagcgtg 3143341 atatagccgg cctcggattc cggcaaatgt aattgatatt catttttcaa aaactccgcc 3143401 agctccagcg cacattgata ggcgaatgaa tacttttttt ggatgaaata aagcatctcc 3143461 tcgtccatac gatggagcgc ttcatttgat tccaaccggc tgaccgcgta tcgcaaatgc 3143521 gtgacaaggc gttgatagga aatgctgttt tcatccacct ttcgattaaa gtattgtttt 3143581 attttctcta tcatttcttt gatcatggtc gtatgcttca gcgctgaata catgctctcc 3143641 gcatccatct tcgccgtatg gatgtgaagg gcaatataac ccgcttcatc ttcaggcaga 3143701 gacacgccca atgtctcttt tacatgtccg atcgcccaca ggccgatctc atattctttt 3143761 ttatagagcg cctttatctc atgcagcaat ttattctgca caagcagccc attttgaatc 3143821 ctttcgatcg caaaggacaa atggtcggaa agcgcgatat gaatgtgatc gctcagcggc 3143881 gccgcgagct ctccttccgc atagctgatg atatcctcag ctatttctat atgctcctcc 3143941 ggcagtgttt gcaggatttg tttgaacttt tcattctcgt cgcgcacgac aaagatcttt 3144001 tccactttat tcatagggat gagatcattt ttcttttttt gaaaagcgat tcccggtccc 3144061 atcacgattt tttcctgatc atcctctttt attaaagccg cattgttgtt taatacttta 3144121 tagattttca agaggttatc tctcccgcca atttgctttt gactgggatt ttacctcctt 3144181 ttgaccgcca tgtaaagatg cgggcccgct ctctcctgct ttggcgattc cttgaaggct 3144241 tgcaaacatc ttcttttata aagcgcggcg gctttcgctt tctgcttttc ttcctcattc 3144301 acagccatcc gccattcata aaacgaaacg agtcctgcgg cctgcacagc cgcctttctt 3144361 tggtatgtac gctgagccga atagaccgcg gcagccgcag tttttctgtc cggcgtcacc 3144421 cagttcatca aaaagaccat ccacacccgt aaagatacaa gcaaacgttt catagaaaaa 3144481 catccctccg cttctttttg gcaggcagcc tttttagcag cccgttttct cagccgcagc 3144541 ccgcaagaaa agacggccga tttcttttct cgcaaactag cggctctagc aaaactcatg 3144601 actctatgat agaccgtgga aagagaattc tttgtcacaa tatgagtgaa aaaaccaact 3144661 agtttttaga agttttgttg aaagctgaaa gaattgaaat gaaaattgga gaaccgcttt 3144721 gaaaacttta tacacaagtt atcccaaaga taagaacaac ttaatcacaa gagatatcca 3144781 catgtccaca aactctatct atattttgta tacgaacgta tattcctaac tatatatata 3144841 cacaggttta ttcacttata cacagggttc tgtgtataac tccttcgtta tacacaaaca 3144901 aaatccaata aatggtccaa atgacacaag gatttttttg aattttcaag aaatatatac 3144961 tagatctttc acattttttc taaatacaaa gggggaaaca cattgaaaaa ggggatcagt 3145021 cagcaaacgc ctcctgcaat aagcgatacg atcggagctt atcttcaaaa tgatgcgtga 3145081 tggtcaccac catgatttcc tctgtttcat acgcgttact caaagctaac agccgctcct 3145141 taacctgttc tttcgtacca acaatcattc gatttcgatt atcagcaatt cgtctctgtt 3145201 cataaggaga atacgtattt ttccgaacag cttcatacga aggaactccc tctaaaggaa 3145261 taccctgctc tcccgccaaa agtgtaaaat caagcacagc cccaagctcc tctgccttct 3145321 cctccgtgtc agcacaaaga acaaaaacag caactgccgc tcgaggcgta tctcctaaca 3145381 cagacggttt gaatcgcctc ttatactgtc tgacagtacc ctctccgccc tctccattga 3145441 taaaatgggc aaacatatag ccagcgccag attcagctgc gagcagcgcg ctttctccag 3145501 atgagccgag cagccacaca tccggagccg ttgaaatatg cggcgcagcg gtcagattcg 3145561 gaaaacggtg tttgtcatcc gccaaatcat gcaaatacat ggtcagctcc ttaatttgct 3145621 gcggatactg atcagcattg cgcttaccac cgtcattcag cgcccatgat gcaatcggca 3145681 ttccccccgg tgctctgcca agccccaggt caattcttcc tggtgtcagc ccctccagaa 3145741 cacgaaagtt ttcagctact ttataagcac tgtaatgcgg cagcatgact cctcctgatc 3145801 caacacgaat tcgctttgtt ttcgctgcta tatgactgat tagcacctca ggactggacc 3145861 ctgccagccg ttttgaaaag tgatgctcag aaacccaaaa tctcttatat ccaaggtcct 3145921 cagcagcttg ggcaagcgca acggtttgct gtaaggccgt ttctgcattg ctgccctctg 3145981 atactggaga ttgatctaat atacttaatg aaaccatccc taccacctca tcctcatcgt 3146041 atcactgatc ccctattttt tctccaaagc cgctcacact gcttatcagt gtcccctatc 3146101 attcgccatt tatttgtgaa agcatgtccc tatttgtcgg aatatgttac acgtgaaaca 3146161 taaaaacccc tccagacgga gaggtttgct ttagttttta ttaaagccct tttctttcac 3146221 gtagtcattt aaatacgtac gcggcttttg cttcataaag ttcagtattt gatcggacca 3146281 cgtttcttcc cgcttcccgt ttgttctttc tctatagtaa tcagaaatgg ttttgtcata 3146341 cgtattcata gtatgacgga aatcgtctgt gttcacatta tacgtatttt catgataaac 3146401 ggcctgcttt ggcaatctcg gttttttgcc ggaaaggttc gcaggatggc ctactgccag 3146461 tccgaaaagc gggagcacat ggtcaggcgt ttgcagcacc tctgtcacct tgtccaattc 3146521 attccgaatg ccgccgatat agcaaatgcc aagccccatg gattcagcgg caatgctcat 3146581 attttgcgct gccagcgccg catcaatcaa gctaaccata aacatttctg tattctcgag 3146641 cagctcagaa atatgttcac ctttttcctc agccagttgt tgatggcggt acaaatccgc 3146701 acaaaataca aaaaagtgtc cgttcttctc aacgtaaggc tgattcccag caagcacgga 3146761 cagctcacgt tttttctcag gatcagaaac cccgataatc gaatatgcct gcacatagct 3146821 ggatgtagac gcagcctgcg cacttttcac taatgtatca atttcttcag ctgtcaaaag 3146881 ctgatcagta aaagaccgga ttgaccgatg attcaaaatg gtttcgattg tgttattcat 3146941 cacaaaaacc tccttatcac tttttatcat atccgaaaaa aagtgatctc aaaagtgaaa 3147001 tgctctgcac aaaaaaagac agcctctgta aaggctgtct gcatatcaag aattaaaaag 3147061 ataacttctg tatttcgtca gctgcacact tgcattatat acaatcccaa atccgattaa 3147121 cgtggaaagt gtcgagcttc ccccatagct gacaaacagc agcggaatcc cggtaacagg 3147181 cataatgcca atgttcattc cgatattctg gaatgtgtgg atcacaatta acgccgtata 3147241 gccaacgcaa aagaaagaag cgaaacggtt aaacggatgt attttgtcta tcagaacaac 3147301 aagcctgtag attaaaaaga agaacatgat gacaacaatt gcacagccta taaagccaaa 3147361 tgactcacct attatagaaa agataaagtc agtcgtactc tctggaacat aaaccttcaa 3147421 attagaaata ccattaccta aaataccacc agatcctatt gccatgatgg cctggtcaac 3147481 ttgccagctg tcatttgaat cttcctgtgt ctcatttgaa gcagacaccc aagaagtgac 3147541 ccgcttaatt tgataatcct gtattccaac tgatttagca acgtcaggaa agtttatcat 3147601 tactaataaa attaatgaaa tgagtaagat acctgaacca gctatgatcg caatcaattt 3147661 ccaatttatc cctgacataa aaaccattac aagaacgata aacatacata ttcccgcagt 3147721 cccagcatcc tgcatcagga taagacctac aggaataact gcgacacccg caatctttaa 3147781 taacaagtgg atatcatccc taagcgtccg aactccttta ggatttgctt ttccaataac 3147841 tgaagcaagc atcataatca aaccaacctt cataaactct gacggctgta ttgttattct 3147901 accgatccta aaccaacttt ttgccccttt aataacaggt gcaatagact cgggactgat 3147961 tttaagaata atcaaagata aaataccaat gataaaaata tataaactta acttttcaag 3148021 ctgttctaaa tcaaagtaca aaagaactgt aatggctaca gcccccaaaa gataaaacac 3148081 aatttgctga atccaatccg tgttcccata ctgcccaaac tgaccggcag catatattga 3148141 tactacgctt ataataaaaa acacaccaaa tataaaaatc aaatccccct ggtaaaaggg 3148201 gctttgctgt ttcttatatc gactcattct atcccgcctt acattttcat cggaaaatca 3148261 ctaatgttta ttatacatga accacgttca agatgacacg tgaagctcgc ttccttttat 3148321 gttttttcag catttgcggc gctttttcag ctacacgaaa tatgacgtat cataaaccga 3148381 aatgtttcga ttgacacaaa acttttcaaa tgaaaaaaac gccataccaa tagaatttgt 3148441 taaaaaacga atgcgataat gtgttatgtt cccaaataat gtgatacctc atatagaaat 3148501 agctaaaaat tcagagcccc atgcccatac attctcctag cacattaaac gaaaaaataa 3148561 gacgatagat ccagtccatt tctgcaaaaa cacgtatcaa tttctggaaa acatggtata 3148621 ataattgtaa cagaatgttc aaaaaacaat cacaaaacag acacaactca gttcctctat 3148681 ttcatttttg taaacgttat cacaaaatga aaggagacgg gtatgatgga catgtttttt 3148741 gcttacttat tggttgccag cgcaacgcct ctctttattt ggcttgataa caaaaaagtc 3148801 gcactctcag ctattccgcc aatcatttta atgtgggtat tcttcttctt ttacgcaaca 3148861 gaaagccttt ctccacttgg acacactctc atgattatct tgtttgccgt taacgtcatt 3148921 gtcgctcata tcgccgcatt tatcatttac ggccttccgt atcttcgcag aaagcgaagc 3148981 agctgaagac agcaaaaaac cctcttccac tgaagagggt tttttgtatt attcgttatg 3149041 gcctgaatgc tctgagtgtt cagcgcctcc aggaggattt ccgtccatat ggtcaccatg 3149101 gtgatagtga gccgcgaaaa tccagatgga tccaagtacg ataacgatcg cgccaaagaa 3149161 tccgaacagc gtgtttccga cttggatcgt gccgttttcg ctctctgtca tatgcatgaa 3149221 catgagaagc tgcagcgccg cctgaatgaa ggcgaagccg aagataatcc aaagttttgc 3149281 tgatgagctc aggtcagtat acactgcaac ccatagagcc agcagggtca aaacgataga 3149341 caggataaaa cctacaatgt gtttccatgg aaagtgactg tgttcagcag atttgtttgc 3149401 cattttacag accccccaat cccatgagat agacacctgt aaagatgaaa atccatacaa 3149461 catctaagaa gtgccagtac aagcttgaga taaagatttt agatgaagtt tgcggagtta 3149521 agccgcgttt cttcaactga atcagaattc ctgtgatcca gaaaatcccg attgttacgt 3149581 gagttccgtg agttccaagt aaaacaaaga atccagacca gaacgcactt gtactgagag 3149641 ccgctccttc atgtacatag tgaacaaact cgttgatctc gcatccgacg aagccggcac 3149701 cgagaagaag agtgataatt gtccaaatga ctacgccttt taaacttccg cggcgcattt 3149761 catgaacagc gatcccgcag gtaaagctgc tgatcagcag caagaacgtc ataatcatta 3149821 ccagattgac ttcaaatagt tcgtctggca agacacctcc agctgttctg tttttaagaa 3149881 cgaagaaggt tgcaaatagt gttgagaaca acacaatttc tgcccctaaa aagatccaaa 3149941 acccgagaat attaagtctg ccggtttcag attgatattc cataggcgcg ttagaattgc 3150001 cgtgttctgc atgttccata actcacgcct ccttattcgg aaatctttct ttccgtctct 3150061 tttatttcat caacactaat gtagtagccg ttgtcgtatt cgaatgaacg cagaaccatg 3150121 cagagcagga ctccgatcaa tccgactacg cccatccagt accattcaaa gacaagtcca 3150181 aagcctgcga gaccgaaggc aacagacata aagaacggtc tgcctgagtt gcttggcata 3150241 tggattttct tgaatttgct ttcagggtat aattcagttt tttcttcttt catatgcagg 3150301 aatgcatctt gagatttgac ttcaggaagc accgcaaagt tgtaatgcgg cggaatcgca 3150361 gaagaagtcg cccaatcaag cgtacgtccc acaccccatg aatctccgct gatttcacga 3150421 gtagagtaac ggaagctgta gtagatgtta tagcaaagga ttaagaatcc tacacccatc 3150481 atgaaagctc cgactgttga gataaagttc aatgttgtcc agccgtcatt cggtccgtat 3150541 gtgtaaatac ggcgcggcat gccttgaagc cccaagaaat attgcgggaa gaaacaaata 3150601 ttgaacccga tcataaagat ccagaagaac cattttccga ttctttcgtt cagcttgtgg 3150661 ccgaacattt ttggatacca gaaaataaat ccggcgaaac aagcaaatac agtacccgca 3150721 atcagcacat agtggaagtg agatacaagg aagtacgtat tatggtattg ataatccgct 3150781 gctgccatcg caagcataac ccctgtaacc ccgccgataa cgaagttagg aatgaacgca 3150841 agcgcccaca gcataggtgt tgtaaagctg attcggcctt tatacattgt aaagagccag 3150901 ttaaagattt taaccccggt tgggattgag attgccattg tcgtaattga gaagaatgag 3150961 ttaacggacg cactgttccc cattgtgaag aagtggtgag tccaaactaa gaaactcaat 3151021 acagagatgg cgataataga accaaccatc gctttgtaac caaacaattg ttttcttgca 3151081 aagcttgaga tgatttctga gaaaatacca aacgccggaa gaataacgat atatacttca 3151141 ggatgtcccc aaatccagaa caagttagcc caaagcatcg gcataccgcc tgcttccaat 3151201 gtgaaaaagt gagcgccgaa caaacgatca aatgataaaa gtgctaatgc tactgtaagt 3151261 acagggaacg caaacacgat aataaccatt gtgatcagtg ttgtccatgt gaacatcggc 3151321 atacgcatta atgtcatgcc ttttgttctc atttttaaga ttgttaccat aaagttgatc 3151381 cctgtcatca gggtaccgat accggcaatc tgaagtccga ggaggtagta gttctcaccc 3151441 ggcccagggc tcatgtcgtt acttgcaagc ggcatataac tcgtccagcc tgcgttcgga 3151501 gaacctccga taacgaaaga aatattgaaa agcatcgccc ctacaaagaa cgtccagaag 3151561 ctcaggttgt tcaagtaagg gaacgcaacg tcgcgggcac cgatttgaag aggcacaaca 3151621 acgttgataa gaccgattaa gaacggcatc gccatgaaga tgatcatgat tgtaccgtga 3151681 gttgtaaaaa tttcattata gtggtttgag tctaaaaaac tgttattcgg aagcgctagc 3151741 tgggcacgca tcatcagacc gtcgacaccg ccacggaata acataattac agcagatata 3151801 atatacatga ttccgagttt tttatggtca acagtagtta tccattcaga ccacagccat 3151861 ttccactttt tgaagtaagt cagaacaaaa ataatggcaa tggttgaaag cgcaatggaa 3151921 acttgtgcgc ccagaattaa tgggtcacca gttacgaaaa attcgtccca tttgaatttc 3151981 atgcaggctt cctcctttcc tgatcaatat cattcttctg tatcatcaga cttcttaaat 3152041 tcgtttttct ttacgttttc aaacggatct gttttagaat gcggtgaaac ggcttgatag 3152101 ccaaggcgtt tgcgcgcctc catcgcgtac tcagcgtctt gtccgtgatc aacgtatttc 3152161 aagtgagtag aagagaacgt taattcgtcc acattttcag gaagcatcaa ttcatcatac 3152221 ttctcttttg tcagcttagg agcctcgttc tgagtctttt tcacccagct gttaaagtct 3152281 ttttctgtga ctgcattcac atcaaactct tggtctgcaa aatgttcacc tgtgaagttc 3152341 gcgttgcggc cttcgtaagt acccactttg tcagcctgta agtattgatc catcagcatt 3152401 cctgccatcg catatttttg ccctccaagc tgaggaatcc atagcgaagc cattgaatct 3152461 gcagatgaga ttttgaacaa gatcgggcgg tcgacaggaa tgtttaagta gttgaccgtt 3152521 tcaatatcct gttcagggta gctaaatacc catttccagt ctaccgaagt agcataaaca 3152581 acaagaggct ctttgtcttt tgttgcttca ggagcttttt ctaacgaata tatcgtctgt 3152641 actgttggca cagaaagtgc aatgacgatt aaaattggga tcactgtcca gactacttct 3152701 aaaaacgtgt taccgtgaat ttctgggtta taagatccat tatctttgcc tttacggtcg 3152761 cggtatttta ctaaaataat ggtaaataga acaaagacga ccccgacgat aaacagcata 3152821 aatccgatag ataacaggat taaatcactt tgctgttcag ctacaggtcc tttcggatct 3152881 agtactgaag cattgctgca tcccccaagg acgaaaacca cagttaacag cgctaataca 3152941 agcaacggtt ttaatgctct gaacaagaag atcaccatcc ttcctattga tgtaataaat 3153001 ctgaagtgca tacttcctca aaatcttttc tctactttgt tatgctatca aaaacttcac 3153061 ttattagctt tattttttta taaacttcat cccattttcg cttaaatgtc ataaaatcga 3153121 caaaaattgc tccaacttta ttcacatcta tcgcttaaga tgaaaagttt ctagttattt 3153181 ccgcatataa agtaaagaaa gatgatgaag aactaattct gacaaattaa ggtttaccac 3153241 aataaaaaac ttaggtcaat caaaaatttc attttgttaa actttctaga taggaattat 3153301 tttttcctcg tctagcatct tttcacacgg ttaccatttt aacgcatcaa atattgaaag 3153361 aaaaggcgca atgaagagcc aatatgctct gaattgtccg tattttttta tgagagcatc 3153421 cagttgttta tcttatacaa aaaagaggaa tgatataagc aaataaataa aaaataggat 3153481 gtgttgcatg atgagttttc ttatttcact tatcgtcgct attattatcg gatggcttgg 3153541 aagcctgttt gtaaaaggag atatgcccgg aggaattatc gggtctatga tcgcaggtct 3153601 tataggcgcc tggatcggac acgggctgct tggaacatgg gggccgcacc tagccggatt 3153661 tgccattatt ccagcggtaa tcggcgcagc cattgttgtc tttctagtaa gcctgttaac 3153721 cagaaaaaga ggataaaagc agcagcaccc gaagcgtcag cgctttgggt gtttgttttg 3153781 ccataaaaat cgaaaaagcc tcaaccctag cggttgaggc ttttgactgg tttggcgccc 3153841 aactgatcga tgaaccttct gaaggcctgt tttccctctg ctgtctgctt aaatacaccg 3153901 gcgtgttcaa ggatgcgcgc gaatacatgt cccagctctt cttttatgac tagatctacg 3153961 ttctcttttg ttatggttct tttttccatc gtccgaagag cccactcact atgctttgca 3154021 gtgagcggat tttgttctaa ggctgttttc ggatcagcag aacatagcgc cgctgccgtt 3154081 tctttcattt cctcctgtaa gcggccaggc aatatcgcca atcccatgac ctcaatcagg 3154141 ccgatatttt cttttttaat atggtggact tcttgatgag gatgaaatat tcctaatgga 3154201 tgctcctcat ccgtccggtt gttcctcagt acgatatcga gttcgtacaa gtctcccctg 3154261 cgccgcgcaa tcggtgtgac cgtattatgg ggcgtatcgc ctgtataggc ggcaatgccg 3154321 gctttttcat cggaatacgt ctgccacgtg cggaagatat ggtcagcagc ttcggcgaca 3154381 tgacccggtt cgtctccttg gagcctgagc acagacatcg gccacttcac taagcccagc 3154441 gacacgccgg gataatcatt taattcataa acgtcttccg cttctgcacg tgccattgga 3154501 aaatcatgcg cgccgccttg gaaatgatca tggcttagga tgctgccgcc gacaatcggc 3154561 agatccgcgt ttgaaccgat aaaataatgc ggatattggc caagaaatga cagcagcctt 3154621 tcaaatgttt ttttgctgat ctccatcggt tcatgttcac cttttaagac aatgcagtgc 3154681 tccggataat agacatatgg cgagaattgc aggaaccatt gttcgtcctc aaggatgacc 3154741 ggaatgattc tgtgattttg ccgggctgga tgattcacgc ttccctcgaa gccgacattt 3154801 tctttacaca gcaaacacat cggataattt gtctgttcct gctcttttgc agccgcaatc 3154861 gctttcgggt ccttttcagg ctttgatagg ttaatggtca tttccagctc gccatattcg 3154921 gtcggcaccg tccaatgaac atttttggcg attctgtcag tccgtatata atagacatcc 3154981 tctgaatatt gatagaattc ctttgtcgcc tgttttgggc cgtataatgc ttttgtctct 3155041 tcaaatttgc gaatgacctc ggacggggca ggcacaaaac agcccatcag ctttgcgctg 3155101 agcaggtcac ggtacgtatc tgtatccgct tccattcggc cggtttcggc agcccattta 3155161 tagatgggag ctagcaagtc cggcaggctt tgtgactgct tgatgctggt gctggagttc 3155221 ggctcgggat gtgtgatgcc cagcgcttca taaagacggt ttctcgtata ttcccgatcc 3155281 cagatcgaaa tcaattttcg ttccaggcca tactcaagca gctgttccag atgttcaata 3155341 atactcatat gtcactcccc ctttagttct ctcgctccct ctccgatatc cgcgacataa 3155401 aagtccgctc ggagccctgt tttttcttga tatctgtctc caaccttctg aataaaatca 3155461 tcaacgaact catcttttac aatgctgatg gtgcagccgc caaagcctgc tcccgtcatt 3155521 cttgatccaa ttacaccttc gtgatcccat gccgcaaaca caagctcatc aagttcaggg 3155581 catgttactt catagtcatc cttcaatgaa aggtgggatt ccttcattaa ctgcccgatt 3155641 tcatctatat tgttctcttt gaacatatgg gccgtcttaa tagcacgatg attttcgtat 3155701 acagcgtgct ttgcccggcg tctgttcgtt tcattttgga tcaggctgga atgcgcatcg 3155761 aaatcagaag gcttgatgtc gcccagtgcg gcaatatcga ggcctttttt cagatcaagc 3155821 aatgcatcat tgcattcttg gcgtctcgta ttatagctgg agtcagccaa tgtccttttt 3155881 ttgttcgtgt tcgcgatgac cagcgcgagg cctgagacat tgagtttgct atattcatag 3155941 tcaagcgtgt cacagttcag cagcatcgca tgatgttttt tccccattcc aattgcaaat 3156001 tggtccataa ttccgcaatt gacgccgata aaatggtttt ccgcatgctg cgccattttc 3156061 acaagctcaa gcgcatctac ttcaggatga aaataacttt ggagcacgac ccccatcagc 3156121 agttcaatag aagcggaaga cgacagtccc gccccgtttg gaatattccc tgaaaataca 3156181 atgtcaaagc catggggaac tgcatatccc ctctgttgaa attcataaat cacgcctttt 3156241 gggtagttcg cccagtcgtc ttctttttga tagcgaatgt cgtcaaggct gcattccttg 3156301 atgcctgcgt ttctaaagtt atctgaatac atccggacaa gcccgtcgtt tctttctgca 3156361 acagcagcat atgtacccat tgtcagcgcg cacggaaaga catgcccgcc gttatagtct 3156421 gtatgttctc caatcagatt cactcttcca ggtgcgaaaa aaaaccgtaa cccctctttt 3156481 tctccgaata cacttgcaaa tatccccttt agctcttccc gcatgtgcaa tcacctttct 3156541 ggtttttatt ttttattccc cttatttctt catagaaaac ggcagatcat atgctgcagt 3156601 cctctcatac cccttcttct tttgtttttt taaagacgag ccatttgctc gcaacatagt 3156661 tgacgacaac aatgaccgcg ttgtcgagta ttttggccaa ggtttcattt gtattgaact 3156721 ggccgacaag aatgatcatc atgcctaaat ctatgccgag agacaggacc cgaacgctga 3156781 aaaaagcagt gagctctttc agcaggctct gcagatcatg tgttttttgc tgaaacacat 3156841 ataatttatt tgttatgtaa gcaaacagca cggacaaaat ccaagcggca acagtggcgg 3156901 ctttgtaatc cacattcatg atctctacca atatataaaa gctggcgata ttcacaatgg 3156961 ttgtgaaaac ccccataatg atatacataa ttatttctct atacttcact gatgttcctc 3157021 gctttctgaa aaacttttca aaattcttgg cctctcgtgc tctctgtcta aagtaaaaaa 3157081 taccgagagt gcgtctaaaa agctgcggaa ggtggctggc tggcccaata catatgattg 3157141 tttgatgatt ccgtcgagga ctgcacatat tattttagcc gtatattcag gatcaataca 3157201 ggcgtcaatc agctttctct ccttcagcca cttaatatat aacacatttt cttccaccca 3157261 caattcgtac agccggacat aggccttgca tttctttaag actttatatg tcggcatgtt 3157321 catggcaaac gaggtgatgt cccacgacgg cttatttatg taataggaat aaagcagttc 3157381 tgcagcgtgt tttgcagcct cgtccaatgt cagcgatttc actgactccc gctccatttg 3157441 atcaagatac cctataatga tctttttttt catctgacgt ttttcgagaa ggtacagcag 3157501 aaaatcgtcc ttgctgacaa aatgaacata aaatgctcct ttgctgtacc cggcggctct 3157561 gctgatatct tctacagaaa ccggatcata cgctcggtca atcaacaaat tcacgccagc 3157621 gtctataaaa ctttcaaatg ttgcttctct tttaatttga aatttgtttt ttttcatatt 3157681 tttctcctgg cggtaatgat tacccttatc ttacaccgga tcaatcttta gcggtattta 3157741 tttctttaaa cggttatgct attcggtttc ccaggggtca tttttaatag gctaaatgat 3157801 ttattttcat ttacatacta tccagtcagt atttaattgt ttattattat aaataaggtc 3157861 cattggttat attagtcatt tttttaggga ataggtaggt ggtttttcct tcagtttgtg 3157921 aacaccgagc aactatgtgt gaaatttgtt gtactcgcct ccatcatcgc gctggcttgt 3157981 cttttattgc ccgcatgttg caggaaaaca ttttatacaa ttggaggtta ctatgaaaac 3158041 tcatgttaaa aaagatttgg acaaaggttg gcatatgtta attcaagaag ctagatccat 3158101 tggattaggc attcatgatg tgaggcagtt tttagaatct gagacagcat caagaaagaa 3158161 aaaccacaaa aaaaccgtcc ggcaagacta gtccgaacag gcggatctat ttacctctgg 3158221 cttttctatc acctgatctg agttttcacc atatcctcta ttcaaaagca aatcgctgcg 3158281 ctgagcttga ggacaaacgg tgtgtcagct aactacgaca gacagccggt gatgcgatca 3158341 cctcttggca catgcattgt cataaagagg tgatgcgaac atgataaccg tgctctggta 3158401 aacagcagct ttgctgagaa caagctgcat tcggtgaggt tttgaaagca aactcgttta 3158461 tacacggccg agcttgaaaa ccttcgcctg tctttagacc actgtgttca cctcttcacg 3158521 acttccttct tttttcatcc tccagctatt gtacaacgca taaatcggac tttcagtaca 3158581 tacctattgg tgtacctttt tgcttacgtt tagcgaataa aaggaggaaa gccatgtaca 3158641 aagctgatta taaacagatt gctgcaacgc cgtcttttca agctttttta aagcagaaac 3158701 gcgcttttat tgttccttct gcgattttct tttttgtttt ttatttttca ctccctgttt 3158761 tgacatctta tttcaccttt ttgaatgcac cggccattgg agctgtttca tgggcttggc 3158821 tgttcgccat cgcccaattc gctatgacct ggatactgag tactgtgtat tcccggagag 3158881 ccgcccattt cgataagtat gtaagcgctt taaaagagga tctgaagggt gaacagacat 3158941 gaatatgact gcttttttat tatttttggc gattgttggc ctgacgctta ttatcacgta 3159001 ttttgccgcg aagcggacga aaacgacgag tgagttttat acggcgggcg gcgggctcac 3159061 cggcgttcag aatggactgg caattgccgg tgactacatg tctgccgcct cgtttctcgg 3159121 gattgccgga atgattgcgt tatatggatt tgatggcttc ttttacagca tcggttttct 3159181 ggtggcttat ctcgttgtct tgtacatcgt ggcggagccg cttcggaatc ttggaaagta 3159241 cacgatggca gacatgattg ccgctcgctt taaagaaaag aaaatccgcg gtgtcgcggc 3159301 tctcaatacc attgccatct ctacttttta tatgatcgcc cagctcgtgg gggcgggcgc 3159361 gctgatcaaa ctgcttctag ggctggatta taccgcggct gtcctcatcg tcggagtgct 3159421 gatgaccatt tatgtcgtgt ttggcggcat gatcgcgaca agctgggttc aaattattaa 3159481 agctgttttg ctgatggccg gcacactcgt gatttcgatt atcgtgtttt cgaaattcgg 3159541 ctttagcctt aataccatgt ttgaacagat gaaaacggct actccgcttg gcgctgattt 3159601 tttgaacccc ggaaataaat acaaggtgcc gcttgagacc ttgtcgttaa acttggcact 3159661 cgtgctggga accgccgggc ttccgcatat attgatccgg ttttataccg ttaaggatgc 3159721 caagacggcc cgtacatccg ttgtgtcagc gacatggatt atcggtgtgt tttacattat 3159781 gacggtattt ctcggctttg gtgccgcggc atttgtcggt tttgacgcga ttacggcggc 3159841 tgatcaagcg ggaaatatgg cggctccgct tttagcaaaa gcgctcggag gagactttct 3159901 gttcgcgttt gtatcagcca tcgcctttgc caccattttg gctgtcgtga cagggttggt 3159961 gctgtctgcc gcctcagcat ttgcccatga tatttacagc cagatcatca gaaagggaga 3160021 agcaactgaa aaagaacaaa tgaaagcggc cagatgggct tctgtcgccg tgtcagtgct 3160081 ctcgattctc cttgcgattt ttgcacaatc cttaaatgtg gcgttccttg ttgcactcgc 3160141 gtttgcggta gccgccagcg caaaccttcc gctgattgtg tttacagtct tctggaaacg 3160201 attcaatgcc tcaggcgctt tatggggcag cctgacaggc ctgatcagcg cgcttgtgct 3160261 ggtatcgatg agccctagtg tgtgggaccc ggccggaggt gctattttta ccggtgatcc 3160321 gctcattccg ctatctaatc caggaattat ttccatcccg ctcggctttc tcggcgcgtg 3160381 gctcggaacg gtgctgtcgt ctgataaaac aattgatgaa gatacgtttg cagaaattca 3160441 ggtgaaggcg catactggcg tccatatgga acaggaataa aaaaagctct ctttatcgag 3160501 agctttttcc ttactttttc ttctgctcgt cagaaatcgc tttttcaaat acatccttgc 3160561 cggcagcacc cggaattaca gtgtcaccga taataaaggt tggaacggct gtgatgtcag 3160621 cctcttcata ggcgtgcttc aaggcttggc gctgcacgtc ctgatatgtt cttgtttcca 3160681 gtgctgattt gaatgatgca ccgtctaatc ccacttcctc ggcgagcttc gtcaagatgt 3160741 caatatcgcc gatattttgg tcctcctgga aaaatgcctg aaagacacgg gtgttgtatt 3160801 catgtccttt attgtattcc ttcgcaaaat ggaagccttc aaacgcgagg tctgtatacg 3160861 gatggggcga gacgtttgga aaattgatct cgactcctaa tttctccgcc attggctgaa 3160921 ttgatgtctg ccacatgtac tgtttagaag gatcattgac cggatcaagc tgaggagatg 3160981 ggcttgggcg cagttcaaac ggcatccact cgacttcaac atcctttcct tttatcgctt 3161041 cttcaaaagc ggcttttcca acaaaacaaa atgggcagac gtaatctgaa taaactttaa 3161101 tgtgtactgt catgataatc tcctttcata ctaaattgat tttaaactgt aacaattaaa 3161161 gttacaactg ttttttaata aagaagccga tttaggcttc tttcagattg atgacaaaat 3161221 cctaaaaagt tttaggattt tgtcatcctt tcagcgtgat tgaaaaccct tgaagtctag 3161281 gaaagccgag cattggagcg gagcgaatgc tctaattcgt gagcaccaac gcacaggctt 3161341 gacaacgaat gcgagggttt gtcgacacgc tgaaagaagc ctgtaaaggc ttcttttatg 3161401 attccagcaa acgctgggca atatattctc cttttttgca gccgcctggg catgcgtata 3161461 aagcagaacc gattgtttgt gtatattcgt ttaacgcatc ctttgctgaa agagccttca 3161521 gcatcgggat aaactgattg tcgggatttt tttgaaaact gataaacagg agacctgcat 3161581 ccatatagcc ggttttcgga tcaagtcctt ctgtgtaaga gaaagctctt cgcaaaattt 3161641 gtttcccagt agatttcgct agactgacgt gtgaattaga cggaatttga ttcagcttca 3161701 cgggatctgt ttcctttttc tgcccaaaag gcgcccccga gctttttctg cggccgaagg 3161761 tatcctcttg gtccttgagg gaagagcggt cccatacctc aaggaacatt ttgattttcc 3161821 gaaaagccat ataggtgccg cccgtcatcc agtcaggctc accagactga atccacacga 3161881 tcgagttcat caacgtgtca tccttcgtgc tctggttgcc tgttccatct ttaaacccga 3161941 agaggttgcg cggtgtttca ccattttttc caccgcttaa aaagcctttg ttcacaaaac 3162001 ggacctcaca agtgccgacc gcttgattta gcaggttacg cagcgcgtga aacgccactt 3162061 gctcgtcgtc tgcacacact tgaatgcaga tgtccccgcc tccctgcttt tcatccaggt 3162121 tgtcattggg catcgctgga agagcggcta ggtgcttcgg ttttttgctt ttcagtccga 3162181 agcggtcctt tccgtctttt tcaaaaaagc caggcccgaa tccgaatgtg accgttaagt 3162241 tggaagggga taaatcagca gactcacctg tatcctgcgg cggcagatac tgatttctct 3162301 gctccgctga cattttcttg ccagacgtca gcatctgtgt gagacttgtc cagtttctaa 3162361 ataacgtaat gatgtcgctt ttgtcttttg ctgttacatc cagtgcagca aaatagacat 3162421 acgtctgatg ggcagttgtg attccggcct gatgctttcc gtaaaacgga acaatctgct 3162481 cctcctcttt ttcatccttt ttcgatggct tagccgcagt ctgaacaagc ggagcgagac 3162541 cgccgagacc gctggcaccg atcgcaacgg ctgcccccgc catcgctccc cattttaaaa 3162601 tgtcccgtct gtgaatttgt tctggctttt tctgttcatc gctcatgatg ttacaaaact 3162661 ccttttatag cacattcgca atcttcgaca tggtttcaga aagagtcgtc agcttagtgc 3162721 tcagctctct gatttgcttt tcacttaatt tatcataaga cgtataggac tgatcatttg 3162781 ttttgtattt tgccattaaa acttcaaatt cgctgaactc cgtatccagt ttttccgtca 3162841 agtcggagtg atcttttaca agcgcgcttt tcactgtttg ataaacggct tcggagcctt 3162901 ccacatttgc cataaggtca actaaatcaa ttcgtgagta gcgctcttct tctcccgtga 3162961 ttttcgaaat tccggcttcg ttcagaagct ccatcgcgcc tgcaacaatt tgttcaggtg 3163021 ttaatttcag tgattgaatt gaaccgtcaa gctcttttac atccttgaga agctggtcag 3163081 ctgttgcctt ttccccggaa atatcttgat ccttccaaat ggccttctca agcttatgga 3163141 agcctgtcca tttgtctcct tcttcaacat cgttttctcg tgcgtcaatt ttcggatcaa 3163201 gatctccgag gctttcagcg atcggttcga ttcgctcgta ataaacacgc gctttcgcat 3163261 ataacgtttt ggacttttcg atatcgccgg atttcacagc acccgtaaat gcttcagtcg 3163321 ctttgacaag ctggtcactc tgctctttga catagccttt atactcatcc gctgcttttg 3163381 ccagctgatc gctagccttt ttgccgctct tcttcgcttc tgtcaggtct tctaaggatg 3163441 ctttcaatga ctcggattct gtcttgattt ttcctgcatc cggtttgtct ttttgcgctt 3163501 ctgtgtagat tggctgaaga tgcttttcga tttctgtata ttcgaatgga tagtcgctgc 3163561 gaatatcgtt ttcaaaggaa agccagtagc tgtttaactc tttccccttc ttttcaatct 3163621 ctttttggtc tcctttttcc actgagtcat tcagcttaga aatgatggtt tccattttat 3163681 ttacggatgc ggtgatttct ttagtgaccc cgcttttttc agatgaagct ttttctttgg 3163741 ttgaagatgt gtcattggct ccgcagcctg cgcacagcgc aaggatgcat ccggctgata 3163801 cagcgatttt tgtgaaattc attttgtcag ttcctttccg tttgtaaaat gttttgccgc 3163861 ttctgaaaca agcgcaatca gtaaaaagag taaaatcaac atttgcggaa tcgtgctgta 3163921 cacagacgga taaattccta gcaccgatac agacggcagc cagctttctg catcagacgg 3163981 aagaatgccc gccagttgaa ggctgtgaac gccggttccg agaaatttca cgcacatata 3164041 caggacaacc gccattgata gaagaaaaaa cggcttcaat ggaatgcgca ttccgagctt 3164101 gatcatcaga acaccgacga tgacgagaac gataagccct gcggcagttc cgccgatcag 3164161 ttcagtgagc gggagcttcc cgacaagccc gatgaaaaag atgaccgttt cgagaccttc 3164221 tcttacaact gccagaaatg caatgagcgc aaaggaaagc aggcttcgtt tttttagtgc 3164281 ctgtgacttc tggatattga ttttttctct ccatttatcc attgaggcgt ttctgtgcag 3164341 ccacaccccg acatacaaaa gcatgacagc ggacagtacg ccggtaacgc cgccaagcaa 3164401 gaaattgttt tctccgaata cactggagga gaacagaacc gtgacaccga tgccggctgc 3164461 taaggaaaca gccatgccgg cggacgcccc gccccagatc catgtcgagg aacgcgtaac 3164521 ccgcgctttt tttgtcatgg ttaatagcgc tccgatgaca aggagggcct ccattccttc 3164581 acgaaccggg atcagcgccg catcccacca gctgtagctg cttgaagcga tcggctcgag 3164641 caattgaatc atttcgtcaa tttgctttga taccttttca ggatggctgc cgatctccgc 3164701 cttcatcagc gccagatttt cctccgatgt cgtataggct tctttcgatt gggacacgac 3164761 atctccctca acagcgagcc aggatgtaac taaattgtcg attgcggatg acgcttcatc 3164821 caattgtttt ttttctatga actgttttgt gtctttcaag ctttgtatat aggctgttaa 3164881 ggacgccctt gattgacctg aggatgtctt tttcagcacg acagcctgct gataggtttc 3164941 taaatgagac gcaagctctt caagctgtgt tttgagctta cgtgcgtctt gattgataaa 3165001 agaaagagaa atcatcgcga tattcgcgtc catttcactg tgagaagaaa ggttttcttt 3165061 cttaatagaa ggttcttctt ttttccactt cgccttgaag gtgtcaaacg tttgttgtgc 3165121 cgaatccata tccccgtctt ttacggattt gatcatttgc ttgtttaatt gaattaatgc 3165181 ggcgatcgga tcatcttccg catgtgccgc agaaccgaaa accatcaaca agctgaatag 3165241 aataagtgcc agcccccgag ccatcatgtt cctcctataa ttgaaaatga ttatcattgt 3165301 ataacataat catagccagt tcctgtcctt tgtcaattaa aatttgaagg tctgaaaacc 3165361 ttgatggaca gcaaaaaagc tgtcctttta cagaacagcc ctttgaagga aaatgaacga 3165421 ttatcttcct gttttatacg tttgaatttc ctcacgaaac ttgcgtgcag cactctcagg 3165481 atcctccgcc tgactgatgg cgctgatcat actgacgcca tcggcccccg cttggataac 3165541 aggtgcggca ttatctattg tgattccgcc gatgccgaca attggaatgc tgatgccttg 3165601 gcggcgcact gcttcgataa gagatacacc ctgtaccgct ctcgtatctt ttttcgtttc 3165661 agtcggatag atcggcccaa gcccgacata atccgctccg tcttcttcgg cttgcttcac 3165721 ctcagacatc gtatgggcag aaacgccgag aatcatatca cctatggcag ctcttacctc 3165781 tttcgcattt gcgtcttcct ggccgatgtg gataccatca gctttcagat tcagagccaa 3165841 ttccacatca tcattgacaa tgaacggaac accagcttca cggcaagctg cctgcgcttt 3165901 ttcagcaaat ttaatccgag cctctcctgt cagcgcatcc ccgccttttt cacggaactg 3165961 gtacagggtg gcaccgcctt ttaacgcttt ttgtacaact gtaacaggat cggctttcgt 3166021 attgtttgac cccataatga agtatacaga taataactct ttcatcattt cccgagaaat 3166081 acgagtcatg agacagtcac cctttctata gtcgcccatt cttggacgtc ttgttcagta 3166141 acagttgaaa gcttgttcag caattcaatc tgaaagcttc cagggccttt gtcagccgtc 3166201 tgctgtgcgg caagctgagc ggcgacccca tacgaagaaa tggccgcaat agcagcaaac 3166261 aatggatttt cttccacagc gcaaaacgca ccgacgacgg aagtcagcag gcaaccggcg 3166321 cctgtcactt ttgtcagcag cttgtggccg ttatgaaggg tgtatacatg tgacgtgtcg 3166381 gctatgacat caacttcacc agttatcgca atgaccgtgt ttagcttttg tgccgcctgc 3166441 tgagccagcc ggatgatgtc gcctccacct tcacccgcat caacaccttt gatcagccaa 3166501 tcggtcacgc cgacggtatg ggcaatttcc gccgcatttc ctctgattgc agcaaggcgc 3166561 acctcacgaa tgatgtcacg tgccgattca gtgcggaacg gtgttgctcc ggcaccgaca 3166621 ggatcaagaa tgacgggaac gccatgttca ttagctgatt ttcccgcgat gatcatcgct 3166681 tcgactgact ccttgctcag tgttccgata tttaaaacga gtgcacccgc aattttcgcc 3166741 atatcggcga cctcttcttt tgcgtacgcc ataacgggcg atgcgccgag cgcgagcagg 3166801 ccgtttgctg tgaaattcgt tacgacattg ttggttatgc tatgcaccag tgggctatgc 3166861 cggcggacag ccgtaagaca ttttgctgct gattgtgcat ccatatttgc atcatccttt 3166921 actatctttt ttcgggtccc ataaatacga tttcgtatgt tcgagccaag ctctggcggc 3166981 aaacgacaag tacctgtcct ttctccaaat aatggcgagg tgccaaggga tgaccggatc 3167041 gacaagcgga atgactttca ctttttccgg gtcaaggccg cggcagatcc gttccggcaa 3167101 aagcccgatc ccaaggttgg cggataccat ctcactaata aaatcccatt gtgatgtttc 3167161 ataaatgata tggggccgga acccagcctt gatacattcc gtcataattc ggttgtgcag 3167221 gacaaaatcc tctctgaaga aaataaaagg ctcgtccttc aactcacgca gctgacattc 3167281 tttctcatca gccagccggt gggaagggtg aacgacaagc attaaggttt cttttacgat 3167341 tgtaaacgaa tgaaagatat cttcgtttgc gggaaggacc acaacgccga tatcaagaga 3167401 gccgtccccg acaccttctt ggacttttat agaaccgtct tcgactagct gaaaggtgac 3167461 attcggatag ttttcacgga aatcgccgag cactctgggg aaaaaccccg atccgatcat 3167521 cggcggcagt ccaatccgta cgtgcccttt cttgacttcc ataatatcat ttaattctga 3167581 cgtcaggttt tgaaatgatt taatgatttc ctgcgcctgc acatacatgc tatgaccggc 3167641 atcagtcagt tccacctgcc tgccgtttcg gtaaaacagt tcaattccga gctcttcttc 3167701 taaatttttg atcatttttg atatcgtcgg ctgagaaaca taaagggatt gggaagcctt 3167761 cgtaaaactt tttaaacggg cgacttccaa gaaatatgtt aaatggcgga tatccatgcg 3167821 cttcaccctt tctatagaca aaaggaatac ttcttattct taatatatat tttacctata 3167881 gagagacctt atgtacaata agtatataag ggaggcatca atatgaaaaa actgttgcta 3167941 accgttattc aaatcgctct gttatttata tttgctcggc tgattaattg ggtgacagcc 3168001 cttcttcata taaatattcc cggcagtata atagggattg tgattctttt cacattattg 3168061 cactttaaca ttatcaagct tgaatggatc gagcttggtg cagcgtggct tctcggggag 3168121 ctgcttttat tttttatccc gtctgccgtc ggagtgattg aatacggaga cattatgtcg 3168181 aaatttggtg tcagcattct gcttgttgtc atcatcagca cgtttgtcgt gatggtgtct 3168241 acaggaacgc ttacacaact catcgcaaag agaaaggaga aaaagcatac gtgttcatcg 3168301 gaattgtaag tttgttttta acggttttgg tgtatttagg agcaaaaaag gtatatcaac 3168361 gctttccgcg tgtttatacg tcgccgctat tggtgacgcc cgctgtatta gtcggtctgc 3168421 tgctgctggt gaatgtcccg tacgagtcct ataatctcgg cggcggattg ctgaccgata 3168481 tgctacagcc ggccaccgtg gcattcgcga tcccgttata taaatatttc cctgttttaa 3168541 agaaatacgc agtggaaatt attttgaatg tggccgtcgg ttcatgcatc gcgattattt 3168601 ctaccgctct tattgcgaaa tggcttcacc tcggcaccgg cttaattgac agcctcgtcc 3168661 caagatcagt gacaacgccg atcgcgatga acgtatctga aatgatcggc ggtatgcctg 3168721 ccgtcacagc cgtgtttgtg attttaaccg ctttgctcgg cacagtgatc ggcccgatgg 3168781 tcatccgtta tttccgcatt gataacgaaa ttgcgcgggg cgtgctgctt ggcacaagcg 3168841 cgcacggagc gggaacgtca aaggcatttg agctcagctc tgtgtccggc acgatttcca 3168901 gcgtgtcgat gatcttagct gcgattatga cgctttgcgc ggcgccgttt ttgctttcat 3168961 ttatgtaaaa aactgtcctc tcgagggcag ttttttttat gtgcttcccc ttattgaaaa 3169021 gctggcgaat tccaatataa tgtatttgtg gataccaaag gaggcaccct gatgcacaac 3169081 ttgcaggtga ggcggcatta tgccgcgtta aaaggatttt atttgtttgc ttttctcggt 3169141 acgggcagca taattccctt actcagtatg tatttaacga aggaacagca tttaagcgga 3169201 tcacaggtcg gcttgatcat gtcactgggc ccgattgtga tgattttctt tcagccgttt 3169261 tggggcatgc tgagcgacta tacgcaaaaa acgaaaggcc tgctggcggt ttgcacatca 3169321 atcacaggca tcattggatt agcctatatt gcatttgaca gtttccctct gtttattttg 3169381 attgcggcct gttttgcagc ctttcaaagc acgattattc cactttcgga cagcatttca 3169441 ctaaggtaca cacaagaaac aaacggcaac tacggcggaa tccgcctgtt tggttctctc 3169501 ggcttcggtg tcgcggtgtt tgccatggga caggtgacga accagctgta ccccattcac 3169561 gtgatcttta tctttggctg tgcctttctg tgcattgctg ccatattggc ttcacaagtg 3169621 cccggccagc agaaaacaac aaaggtcaat atccgcaaag gattccggga gcttatcagc 3169681 aacaaaactt tcctcatctt tatgatcatc acctttacga catttgctcc aaacttagcg 3169741 aacaatacgt atttcagtct ttttctggac aaaagcggcg cgtcactttc cgctatcggc 3169801 attttatttt tcatcggtgt catttcagaa attccattta tgagattcgc ccaaacattt 3169861 atagataaaa tggggctgct caacgtcatt atgctgtcag gcggagtctc attattcagg 3169921 tgggcgctct atttcacggc gccttcacta tggatcattt atgcgacggt ctttcttcag 3169981 ggagtggcca tcggtttatt tatcccggcg gcgcttcaat atgtgaaaaa gattacccca 3170041 agacacgttg aagcgacggc gctgaccatg tacgccgcca ttggcaacgg gttcggcaac 3170101 tggttctgca catttgcagg cgggtacatt tttgactacg tgtcgatctt cgcagtctac 3170161 ttgctttttg gcattctgag catagcaggc tttggcctga cattatattt aatgaaggct 3170221 gaaaaaaaca aacatacact tcatcagccg gctgttactt ttaaaccata atgactataa 3170281 tgaacaaaag aaaggatgtg cgttatgaac gggcaagagc gaaacagcat ttcgaaaggg 3170341 ttgcaggttg atattgtatt gaaagcagat caaaaaacag gaaaactgac gagagggaca 3170401 gtgaaggata ttttgacgaa atcaaacttt catccgcatg gcattaaagt ccgtcttgaa 3170461 gatggccgca tcggccgcga ccagcagatc gtttctacat aaaaaaaagc tgcccctgaa 3170521 cagggcagct ttttcattat tttttctgca gaaggaccac tttcaggtag ttgccttccg 3170581 gaaatgccga aatcgttttg aaatcctccg gcagcgtaaa ttcctcaatg atcgtgtagc 3170641 gttcatttgt ttctttaaag gcggcatcaa taaagccttt gaacttcttc atgccaaagg 3170701 cgctgctgtt tgtagaggca acaatgacac ccttgtcagc agtgatggcg atcgtttcct 3170761 tcagcaggtt tttataatcc ttggccgcgc tgaaggtgcg tttttttgtg cgcgcaaagg 3170821 aaggcggatc tagaataatc agatcaaagc gcaaatcctt ttttgcagca tatgaaaaat 3170881 agttaaaaac gtccatcact ttaatgtcgt gcgcttcgta atccagcttg ttcacgctga 3170941 attgctcgat cgttttggca agacttcgat ttgccacgtc gacgcttgtt gttttctccg 3171001 ctccgccaag cgccgccgcc acggagaatg cacccgtata agaaaacgta tttaaaacgg 3171061 ttttcccttt tgcatagcgg tctctgatcg ccttgcgcac atgtctctga tccaaaaaga 3171121 tgcccgtcat ggcgccttca ttcagatcca ccgcgtattg aatgccattc tcttggatga 3171181 tgatcgggaa ctcgcccctt ctccctttca cgaagtcatc atcttcaacg tattgtccag 3171241 ccgtgtcgaa gcgtttcttc tcgtaaatcg ctttataatc aagatccatc tcatccaatg 3171301 cggaaatcag catgtcttta aaggtgtaaa ttcccttgct gtaccattga atcagcaggt 3171361 agccgtcata atagtcgatg gtgacgccgc cgacaccgtc accctcaccg ttgaacaggc 3171421 ggaaagctgt tgtatcttga gcctcaaata gtttggcgcg cgcttgggcc gcttttgtta 3171481 atttgctgag aaaaaatgct tggtcaatct gttcatgttt attgcgggta agcgtccagc 3171541 caaccccttt gttttgcagg ccgtaatagc cccgcgcgag aaactcgccg ccgctctcag 3171601 acacgatatc aacgaggtct ccttctttca tgtgccccgc actccctgcg agagcttctt 3171661 tttcaataag gggatagcct ttttttattt tggcagcgtg tgcttttttt agggtgagta 3171721 gcttcatata tgtcgtcctc tttccgtttg ctttctctta tggtaccaca aaacgccaag 3171781 atgtctgcat tgacagaaag gaaaggtttt tctacgatag acaaaaagag ttacgaggag 3171841 gagcagcatg gcaaaacgaa ttgaccatac aggcatcatg gtaagagata ttaacgcgtc 3171901 catcacattt tatgaagagg tactaggcat gaaattgaag gatcgcatca ctcacacgaa 3171961 cggtgtaatc gagcttgctt ttcttggctt tgaagacggc ccggaaacag aaattgaact 3172021 gattcaaggc tacagcagcg agcttcccgc tgaaggaaaa gtgcaccaca ttgccctgct 3172081 gacggatgac atcgcggctg aatatacaaa agcggaaaaa atgaacgcaa aatttatcga 3172141 cgaggagatc acaacacttc caaacggata ccgttatttc tatatcgaag gccctgacgg 3172201 tgagtggatt gagttctttc agcggtaaaa ataaagaacg tacattttgt gatgtacgtt 3172261 cttttttatc tataccaact gatatacggc tatacagcca tgaacagcat aaaatgaacg 3172321 ttattacagt tatcaccaca tatggcggga ttgtgactgg gcaggcaggc aagacccaat 3172381 gatgcaaagg gagtattaat gcctaaaaaa cagggcattt taactcttct tttcgtgttg 3172441 ggctcataac ggcgccttgg acaaccccct attctcatgc tccgtcgtcg acgcgggcat 3172501 ttttgtcatt ttcagccggt atttctcact tttttcattt tgattgtcaa cttttcattt 3172561 gatacgatga acaagccgac ttttcttcag caaaggaggt tttaattgct tgcataaaga 3172621 gattgcaaaa gaattactgc tgctcgcagg aggaaaaaac aatattatca gcatcagcca 3172681 ttgtacgacc cgtcttcgtt ttgatgtaaa ggacgagacg aaaattgata tacatgccat 3172741 tgagaacctg caaggtgtgc agggcacctt tttccgctat gggcttttcc agattatctt 3172801 cggagcaggc gtcgtcaaca aaatatataa agaagtcgtt catgtatggg agaccgcgcc 3172861 ttctgaagag cctgtccacc agaaaaaagc cagccggaag ctgaaccctg ccgcagcttt 3172921 tgcgaaaaca ctgtccgata tttttgtgcc gattattccg gcaataacag caagcggcct 3172981 gctcatgggg ctgatcggca tgattaaggt gtttcattgg ttcgctgccg gcagcccatg 3173041 gattaaaatg ctcgacctcg tgtccagcac agcctttatt ttactgccga ttttagtcgg 3173101 cttcagtgct gcacggcaat ttggcagcaa cccataccta ggggcagtga ttgcagggct 3173161 tttgacgcat cctgatctgc tggacccgtc tatgctcggc agcaaaaccc cgtcttcttt 3173221 agacatatgg gggcttcata tcccaatgat gggctatcag ggttccatga taccgattct 3173281 tctttccgtt tttgtcatga gcaaaattga gaagctatta aaatcgattg tgccgaagtc 3173341 gcttgatgtc gtgatcattc cctttattac ggtcatggtg acagggtgcc tcgcgctgat 3173401 tgtgatgaat cccgccgcgt ccatcatcgg ccagatcatg acacaatcga tcgtctatat 3173461 ttatgatcac gccggcattg ctgccggagc tcttttcggc ggcatctact ccaccatcgt 3173521 cctatctgga ttgcatcata gcttttatgc aattgaggca acgctgcttg ctaatccgca 3173581 tgtcggtgtc aactttttag tgccgatatg gtcgatggcg aatgtggccc aaggcggagc 3173641 ggggcttgcg gtattcctca aaacgaaaca atcaagcctg aagaaaattg cgctccccgc 3173701 ttctctgacc gcgtttttag gcattgttga gccgattgta ttcggggtaa atctcaaatt 3173761 gatccgtccc tttatcggag cagccatcgg cggtgctatt ggcggagcat acgtggttgc 3173821 ggtacaagtt gtggcaaatt cctacggact gacaggcatt ccgatgattt caatcgtgct 3173881 gccgtttggc gccgctaatt ttgttcatta tatgatcggt ttcttgatcg cagccgtctc 3173941 tgcttttata gctacattgt ttctcgggtt taaagaagag acagaataac tggatttatt 3174001 cgatttcatt cataaaacgg gggatgaaag gacaaaaaag ctatgaaaat taaaagaatc 3174061 ttaaatcata atgctatcgt cgtaaaggat caaaatgaag agaagattct cttgggtgca 3174121 ggaattgcgt ttaacaaaaa gaagaatgat attgtcgatc cgtcaaaaat agaaaaaacc 3174181 tttatcagaa aagatacacc tgactataag cagttcgaag agattttaga aacattgcct 3174241 gaagaccaca ttcagatttc tgagcaaatt atctctcatg ccgaaaaaga gctgaacatc 3174301 aaaatcaacg agcgcattca tgtcgctttt tcagaccatc tttcttttgc aattgaacgc 3174361 ctgagcaatg ggatggttat caaaaatccg ctgctgaatg aaatcaaagt cctttatcca 3174421 aaggagttcc agatcggctt atgggccaga gcactgatta aagataaact ggggattcac 3174481 attcctgatg atgaaatcgg caatatcgcc atgcatatcc acacagcaag aaacaatgcc 3174541 ggcgatatga cacaaacgct tgatattaca acaatgatcc gtgatattat cgagattatc 3174601 gaaattcaac tgtctattaa tatcgttgaa gataccatct cttatgaaag gctcgtgacc 3174661 catctccgct ttgccattca gcatatcaaa gcaggcgaat ccatttacga gctggacgca 3174721 gaaatgattg acatcattaa agagaagttt aaggatgcct tcctgtgtgc cctaagcatc 3174781 ggcacctttg tgaagaagga atacggcttt gagtttcctg aaaaagaatt gtgctacatc 3174841 gccatgcata ttcagcggtt ctaccaacgg tcagtcgcac gctgagacaa acaaaaaacg 3174901 cttttgatca tctcaaaagc gtttttttat ctgatttatt ggttgatcgc cggattccca 3174961 atcgtattcc acttcgtata ggacatgtaa tggaaatact catcgcgata cggatgtttt 3175021 gtattggagt tccaaggctt ttctccgccg cagaagtgca cgattgccgg gttttctctt 3175081 gtttcattat attgcttccg ccctaacaga gtcgatgggg ttttcagctt taacatgata 3175141 taggtttgag cgttccagcg cggatgaagt tcataccact gatcatacaa gatcgcattc 3175201 agtgcatctt ggtcatgcag cacaagaaag tcttcgtctg ggtgttcatt gataaagttg 3175261 atgacttttt ctgtgatgtt ttgctttctc caagactcaa aatcaataat catgatacct 3175321 gagttaaaat acttccctgt atcagtgacg ttcatttctt tcaggcgttc atgctgcccc 3175381 gcatcctcaa cagcggctac ggtgtatggc gcaatgtcta agtcccatag cttagaaata 3175441 tcctctagga caagcgcatc acaatcgatg taaatcattc gtttgatgct ttcatcctta 3175501 attaagtcgg gaatcgaaat gcggtaatac gcggcttttg taatatggct gctctcaacc 3175561 gcatgttcat acatgttggt atccacttct aaaaactcaa tcggcactcc gaatttcaaa 3175621 gtggtttctt ccagtctttt tttgttatca ggcttaattc cgccatcaat gacgtataat 3175681 tttacctctc tctcctgatc catgttagtc aataaagaaa cgaacatccc acctaaatga 3175741 cgagcataat tatcatctgc gcatgatacg atatgcatga tttcatcttt cctcaatggt 3175801 attcatctcc ctttttgttg tacaagttac ataccctttt tcaaaaaaat aaacacgttc 3175861 tccgacattt ttttaaacag aatgtgtgat acaacaaaaa aggtgtcatt ttttgaagat 3175921 gcgataaagc caataaagaa tgaaaaagct tgcgattgtg atggcttcag ccgagacgat 3175981 ataccacggc catggcccga gaacatctaa gagagaggaa ccgcccggtt ttttcgtcaa 3176041 atacatataa ttcgcgccaa gccagcgatc aatcagaaaa atacagacgc cgtacacatt 3176101 aacaagcagg actgtcaccc ataacgagcg ctggcccatt ctgtaggtgc caatcacagc 3176161 catcagcaga caggataaaa acacagaccc gtgagaaata aaaaagagga tatatcggat 3176221 atgcggaaat gaaaacatac cgaggtcagg agtggcaaga gcctgaatcg aactgccgat 3176281 gccgacaaaa aacaaaaaca caaacagctt tctgcttttt gtcactaaca taatagctga 3176341 caaatacacc gacaggtcac taagctggag aggcaatgaa gtgcgcaccg accacctgtc 3176401 cgtggcgacc atccatattt gatagccgat ttgcgaacca agcaaaagaa acacaaacag 3176461 agaacgcaaa aaccggctgg ccctcggctg cttgacctca tcttggaaca aaaacaacag 3176521 aatggccaaa agggagataa tcgctaacgt cactacatgc tctgtcgaaa acagatgaaa 3176581 cggatcatgc ttatagtcgg attgaacata tttttgcaaa actgcacccc cgttttcggg 3176641 tttttgttta ttttggcgtt gtttgggctt tttttattca accgatatat gggcttgaag 3176701 ttcacaccag actctgttaa aattcgtttc atagctaatg attctgataa tttaaggcag 3176761 gcctaaaaaa tggaacgttc acatcaacat cagcagcttc ggaaggaaga acacgataca 3176821 ctttctaagc tcaaacaaat gcccgtcgag tcactcaacc tggaagccat ttcgatcgct 3176881 acgaatctgt atcggtctgc acaaaggctc cgtgtcaaaa tggagactga ggttctttct 3176941 acctataacc tttcttggac cgctttctcc attctttatg atctatgggt atggggagcg 3177001 ctcgaaacga gaaaaatcgc tgagctgtca gggatatcta cagctacagc aagcaacgtg 3177061 atcaaaacgc tcgaaaaaaa gagtttttgc cgtaaaagca tcgacacaag agatcggcga 3177121 ctcgtgtttg tctcaatcac cgattccggc aaacaagcga tcgaagaact ctacccggag 3177181 tttcacaaag gggaaacaga gctcattgcg ggaatgacga aggacgaaca gaaaatattg 3177241 acagggctgc ttagaaaggt agctgacaat cttcatacaa cataagcttt gacgggaatc 3177301 cagtagcggt ttgtctccct gtttcagaga gccggcggta ggtgcgagcc ggcgcacagg 3177361 caaacgtgaa ttacctcccc aagctttctt tgtgaacctt agtagcaaag aacgggaaac 3177421 cgttattcga atgagcggaa gacaatgtct tcaaccaggg tggtaccgcg tgcattgagc 3177481 cacgtccctt attgggatgg gctctttttt gtgtttgtaa aaaaggagga aaaatgatga 3177541 gaacatttga gcagctcaca gcgtcacaac aaaaagaggt agaaagacag cttcagctat 3177601 acatgacagg cgcccacgaa gtcataccgc cggaggaatt aaaggcaaag ctcgtgaaat 3177661 caatttccac gggcacgccg cttaaaatta agctcggatt agatccgtct gcaccggatg 3177721 tacatttggg ccatacggtt gtgttaaata agcttcgcca atttcaagaa aacggccaca 3177781 ttgtccagct gttaattggg gatttcacag gaaaaattgg tgatccgacc ggaaaatcgg 3177841 cagccagaaa gcaactgact gatgaagaag ttcagcacaa tgccaaaacc tactttgagc 3177901 aattcggaaa agtgcttgat ccagaaaaag tcgagcttca ctataactca aaatggctga 3177961 aaacattgaa tctagaagat gtcattgaat tagcagggaa aataacggta gcccgcctga 3178021 tggagcgcga cgactttgaa gaacgcatcg ccatgcaaaa accaatctca ctgcatgaat 3178081 tcttttaccc attgatgcag ggctatgatt ctgtcgttct cgaaagtgat attgaattag 3178141 gcggaacgga tcagcatttc aatgtcctca tgggacggca tttccaagaa cgatacaaca 3178201 aagaaaaaca agtcgtcatc cttatgccgc tcttggaagg cttggatggc gtcgagaaaa 3178261 tgtcgaagtc gaaacacaac tacattggca ttaacgaaca tccaaacgac atgtacggaa 3178321 aaacgatgtc actgcccgac agcctgatga aaaagtacat ccacttggcg acagacttag 3178381 agcttgaaga gaaaaaacag ctcgtaaaag acttagaaac cggcgccgtt catccgcgtg 3178441 atgccaaaat gcttttagcc agaacaatcg tccgaatgta tcacggagag aaagcagcag 3178501 aagctgccga acactcgttt aaaacagtct ttcaggaaaa cagcctgccg gaagatatac 3178561 cggccgtaaa ctggaaaggc gaaaaaacga tagcgatgat tgatctgctc gtcaagctaa 3178621 agctcctctc ttcgaagagc gaggcgcgcc gcatgattca aaacggaggt gtacgcatcg 3178681 acggagagaa agtaacagat gttcacgcca aagcagagat aagagagaat atgatcatcc 3178741 aagtcggcaa acgcaagttt ttaaagctcc aataatctga tattccgaaa cgcttatgac 3178801 ccttcattca taagcgtttt tttgcaggta taaagcactg tcttttcaaa aacgctctcc 3178861 atcttgcagg aaactccttt agcatcccga aatattcccc aaccatacat ttaggggagg 3178921 tttatttttg atgaaaaagc ttttgactgt catgacgatg gctgttttaa ctgccggcac 3178981 actgctcttg ccggcacaga gtgtcacccc tgccgcgcac gctgtacaaa tatcaaatag 3179041 cgagcgcgag cttccattca aagcaaaaca tgcgtactct accatttctc agctaagtga 3179101 agcaatcggc cccagaatag ccggaactgc agctgaaaaa aagagtgccc tattgatcgc 3179161 ctcatcaatg agaaaattaa agcttgatgt gaaggttcaa cgattcaaca ttcctgaccg 3179221 gcttgagggt acactgtctt cagcaggacg cgatattctt ctccaagcgg cgtcgggctc 3179281 agctccgact gaggaacaag ggctgacggc cccgctttac aatgcgggat tgggctatca 3179341 aaaggacttt accgctgacg ccaagggcaa aatcgccttg atttccagag gagacctgac 3179401 ttattacgag aaagccaaaa atgccgaagc cgccggagcg aaagctgtca tcatttataa 3179461 caacaaagaa agcctcgtgc ctatgacgcc aaacctgtcg ggaaataaag tcggcattcc 3179521 ggtcgtcggc attaagaaag aagacggcga agcacttacc cagcaaaaag aagccacctt 3179581 aaaactaaaa gcattcacaa accaaacctc ccagaatatc atcggaatca aaaaaccaaa 3179641 gaacatcaaa catccagaca ttgtgtacgt gaccgcccat tacgacagtg ttcctttttc 3179701 gcccggagca aatgacaacg gctcaggtac ctctgttatg ctggagatgg cgcgtgtctt 3179761 aaaaagcgtt ccatctgata aagaaatccg ctttatcgct ttcggcgccg aagagctcgg 3179821 cctgctcggc tcctctcact atgtagatca tctatcggaa aaagagctga aacgaagcga 3179881 agtgaacttc aacttagata tggtaggcac aagctgggaa aaagcgtctg agctgtatgt 3179941 caacacattg gatggccaat ctaactatgt ttgggaatcc agccgtacgg ctgctgaaaa 3180001 aattgggttt gacagcctgt ctctgacaca gggaggatca tctgatcatg tgccattcca 3180061 cgaagccggc attgattccg ctaactttat ttggggagac ccggaaacag aagaagttga 3180121 gccgtggtat catacccctg aagactcgat cgaacatatc agcaaagaac gcctccagca 3180181 agcaggcgat cttgtgacag ccgctgtcta tgaggctgtg aaaaaagaga agaaaccgaa 3180241 aaccattaag aaacaaatga aggcgaaagc atctgacatt tttgaagata tcaaataaaa 3180301 aaagacggca cttgggtgcc gtctttttta atccacttct ttcttaatcc ccagcatttt 3180361 ctcatctagg taatgggcaa tctccgcggc ttctttcagc tcatctgtta attgcttagg 3180421 aacgtcattg ttcaatttat aataaatttt atgttcaagg ctcgcccaga aatccatcgc 3180481 gattgtccgg atttgaattt ctgctttgac gtattccaca cggttcgtta aattcacagg 3180541 catctcaatg attaaatgca ggcttcgata gccattcggt ttgggtgtct ggatataatc 3180601 ctttaccttt acgattctca aatcttcatg ctgcttcaac acattcacga cattataaat 3180661 gtcagaaata aaggaacaga tgatgcgcac gccggcaatg tcgtgaatat gctccttcat 3180721 ttccttcgtc gtaatctcac agccctttct cattaactta ttcacgatgc tttcaaagct 3180781 ttttacacgg gattttgtat gttcaatcgg gttgtgtccg tgaatgaggt tatattcctg 3180841 gctgataatt gagaactttg tatcgagcgc atctagcgca aatttataaa ctaataactc 3180901 atttttccaa tcttccatta ctgtttttaa atcgtccata tgtgttacag ataaatccat 3180961 gttcgtcatc tcctttaacg gaactttatc cgctgtccat gtactagacg tccctgtctg 3181021 ctgcaaggtt ctatgaattt ttttacaaaa tgcggtcgat tgtaacaaaa aaagaccgca 3181081 tgaaacgagc ggtctttttt attatcggaa atagctgatc aataatccga tcgagagcag 3181141 gaatccgaaa aatgtatttg tttgggctgt tgatttcatt gcgacaatca tattcatcgg 3181201 catttcgttc tggacgaagc ccttcactgc ctgaaccggc ttaggcacgc tcaaaaagac 3181261 gacaaacagc catgggcttg cggcaccggt aataaccaag ccgacaaccc agatataagc 3181321 gacggcaaac gacgcagcta acagagtaac agctccctta tgccccatca aaatcgccaa 3181381 tgttttgcgt ccgccttttt tgtcctcttc aatatcacga atgttgttcg acaggttaat 3181441 cgcgccgaca agaatcgcaa tcgggatgga aatcaaaatg ctctgcatat tgatcttatc 3181501 tgtctgaatg aaaaacgaaa tcagcacaaa caccgaaccc atgcaaatgc ctgagaataa 3181561 ttcaccgaac ggcgtgtacg caatcggcag cggcccgcct gtatacaggt agccgatcgc 3181621 catgccgaca aggccgatca gcgcaagcca ccagctgctg ctggcacaaa tatagacacc 3181681 gagcaaaatg gcaatcccgt atgaggcaag agctaattgc aaaatcgttt taggcttcat 3181741 tccgtggcgt acaatggccc ctccgattcc gactgattct gctgtatcta atccgcgttt 3181801 aaaatcatag tattcattaa ataagttcgt cgcgatctgg atccataggc aagaaaacag 3181861 catagccaaa aacagcagca gatcaacctt cacataaaac atcgccaaaa cggttccgag 3181921 cagcacaggc acaaacgatg cggttaacgt atgaggacgg gttaactgcc aaaggatctg 3181981 ccccatgctt tctttttgcg gcgctgtctg accctcaccc ttatttgttt ggttcatctt 3182041 cctcttcctt tctattaaaa ggcttacttt ttttcagccg gcagcttaat aaaaaactcc 3182101 ttttgcttcc ttatctatca taatgacttc tcccttattt cacaagatac cgcaagaagg 3182161 cgttttcttt cttattatac gcttctcgcc ctgatttcat taggtttctg ctttcacttg 3182221 aacgaacagg tacagaaaaa tttttttaag tacattacac tttttaaaag ttaaaaagat 3182281 cttttgactc caggtatctt ttcctttatt atgaatcagc tcgaaacatt ccattcttgc 3182341 ccttgcaggt ataaagattc attttcaaaa acatacgccg atatattaat ttgagggaga 3182401 ttagggaaaa aatgaaactt tttgagcatc tgatcgtcaa ataatcatgt gattgtcgaa 3182461 aaaacgggaa gggaattttt gatatgctgc aattaatgaa acagctgtat gaaaaacccg 3182521 ctgtcaagtg gacatgtcat acaggctttt atttgatgat actgcttgtt ttgtttttta 3182581 tgtatggttt tcacaccgcg aataccggtt catatattta taacgatttc taattggaga 3182641 gagaataact atgaaacttt tacatgctat tcaaacacat gcggaaactt atccgcaaac 3182701 cgatgccttc cgctctcaag gccagtcgct cacgtatcag gaattatggg agcagtctga 3182761 ccgcgcggct gccgcgatcc aaaaacgcat ttctggggaa aagaaatctc ctatccttgt 3182821 gtacggccac atggagccgc acatgatcgt ttccttcttg ggaagtgtca aagcgggaca 3182881 tccttatatt ccggttgacc tgtctattcc gtccgaacgg attgcgaaaa ttatcgaaag 3182941 ctctggagca gaattgctga tccatgcagc aggactctca attgatgcag tcggccagca 3183001 gattcagaca gtttctgcgg aagaactgct ggaaaacgaa ggcggctctg tcagccaaga 3183061 tcaatgggtc aaagaacacg aaacgtttta tatcatttac acttccggga gcacaggaaa 3183121 tccgaaaggc gtgcagattt ccgctgcgaa ccttcaaagc ttcacagact ggatttgtgc 3183181 agactttcca gtcagcggag gaaaaatatt tttaaaccaa gcgccgttct catttgattt 3183241 gtctgtcatg gacctatatc cgtgccttca atcaggcggg actttacatt gcgtgacaaa 3183301 ggatgctgtg aataagccga aagtcttatt tgaagagctg aagaagtccg ggctgaatgt 3183361 gtggacatca acaccttcct ttgtgcaaat gtgcctgatg gatccgggtt tttcacagga 3183421 tctgctgcct catgcggaca catttatgtt ttgcggagag gttcttccgg tttctgtggc 3183481 caaagcgctg cttgagcgtt ttccgaaagc gaagattttt aatacgtacg gcccgactga 3183541 agcgacagtg gctgtcacat cggttgaaat tacgaatgac gtcatcagcc gcagcgaatc 3183601 gcttccagtg ggcttcgcca aaccagatat gaacattttc attatggatg aagagggaca 3183661 gccgcttcct gagggagaaa aaggagaaat cgtcattgca gggccgagtg taagccgagg 3183721 ctaccttggt gagccagagc tgacggaaaa agcgtttttc tctcatgaag gccagtgggc 3183781 ataccgaact ggcgatgccg gctttattca agacggtcag attttctgcc aaggacgttt 3183841 ggattttcag attaaacttc acggctatcg aatggagctg gaggaaatcg agttccatgt 3183901 cagacagtca cagtacgttc gttctgctgt cgtgattcct tatcagccaa acggaacagt 3183961 tgagtatctg atcgctgcta ttgtgcctga ggagcatgag ttcgagaagg aattccagct 3184021 gacaagcgct attaaaaaag agcttgccgc ttctcttccg gcatatatga tcccgagaaa 3184081 atttatctat caggatcaca ttcaaatgac ggctaacggc aaaattgacc gaaaacgcat 3184141 tggcgaagag gttcttgtat gacgccttac agctcgtttt tattctttat actgcttggc 3184201 attcttcttc tgccgacgat cattctcggc ttaaacggaa aaagatttca agcatacaac 3184261 atgttcatat ctatcattat attggcttta attttttcgc acgacttaca cggggtcatc 3184321 gcgctgtgcc tgtttacaat atggcaggtg ctcctgatca gcggctatct ggcataccgg 3184381 cagaaagcga acagcggctt tgtcttttgc ggagctgtta tcgcgtctat tctgccttta 3184441 tttctgtcaa aaatatggcc gtttctttca cacccgcagc cgcatcatcc gccgcataac 3184501 ctgatcagct ttttagggat ttcatattta acctttaaag gcgttcagct gattatggaa 3184561 gcaagagacg gactgctgaa agaacagctg ccattgcacc gtctgctgta tttcatcctg 3184621 tttttcccga cgatttcctc cggcccgatc gacagatacc gccggttcgt caaggatgaa 3184681 cagaaggctt ggacgaaaga agaatacgcc gacctgctgt atacgggaat ccataaaatc 3184741 ttcatcggtt tcctgtataa atttattatc ggctacgcga tcaatacgta cttcatcatg 3184801 aatcttcccg caatcacgca caataagatt cttgggaacc tgctgtacat gtacggctac 3184861 agcatgtatt tattctttga tttcgccggc tacacgatgt ttgccgtcgg ggtcagctac 3184921 attatgggca ttaaatcacc agaaaacttt aataaaccgt ttatcagtaa aaatattaaa 3184981 gatttctgga atcgctggca tatgtctctg tcattttggt tcagagatta tgtgtttatg 3185041 agattcgtat tttggatgac taagaaaaag tggatcaaaa accgtatggc cgtctcaaac 3185101 atcgggtatt tcctgctgtt tatgctgatg ggggtttggc acgggctcgc gccgcaatat 3185161 atcatttacg gcctctatca cgccgttctg atgacgtgtt acaacttttt cgagaagtgg 3185221 aataagaaat ataaatggct gccgtccaac cgctggacaa ccattctcgc tattgtgatc 3185281 acattccatt tcgtttgctt cgggttttat attttctcag gaaaaccatt tcatcaccac 3185341 cattaaagga gattagaaag ctatggattt taaacaagag gtattagacg ttttagcaga 3185401 ggtttgccag gatgacatcg taaaggaaaa tcctgatatt gaaatttttg aagaaggttt 3185461 gcttgattct tttggaacag tagaattgct gcttgcgatt gaaaaccgtt ttgatatttt 3185521 agtgccgatc actgaatttg accgggacgt ttggaataca cctaacaaca ttgtaaatca 3185581 gctgtctgag ttgaaataat gaaaaagcgt tttttcggtc caattatttt ggcgtttatt 3185641 ctattcgcag gcgccatcgc aattccatct tcatggctga caggcttcat caccgataag 3185701 cgtgtgaaag agtcagcaac agccttgaat ccgagtatgt ttcaagggct atatttacaa 3185761 gatcagatgc tcaaagatcc gacatatctt ccgatttacg ggtcttctga gctttctcgg 3185821 ctggacgagt tccacccatc taattatttt caggtaaaca atgagggatt cacgccatac 3185881 cttgtcggca aaggcggatc ccagtcattg attcattctt taaacttcgc tgcccacatg 3185941 gatcagctga agggcaaaaa aatcgtattc atcgtgtctc cgcaatggtt tattaagcgc 3186001 gggtctgatg aacagcattt cgcgccgaac tattctgcgc tgcaagggct tgatttggca 3186061 tttaacgatc agatcgatcc tgaaattaaa aagaaaatga tgaaacgcat gcttcgcttt 3186121 aaggctgtgc aaaacgatgc cattctttct gagctgtaca aagcaatggt aaacggtcag 3186181 acgtggaaag tgaacgcgct gaagccggcg gcgaaagtgt attacagcat gctggaaaag 3186241 aaagatctgt attattcaac gacagaatca tccgggccaa agcgctatat ctcgcagtca 3186301 gtaaaggata agtcatggtc tgaattgaat aaactagcgg atcaatcggg caaacgccac 3186361 tccggttcta acgattttca catcgacaac cctgtctata aaaagctgaa gccgaaagtg 3186421 cctaagctga aagggaaaaa caaaggaaga tcgtatgcgg tgtcaccgga atatggcgac 3186481 tttgaaatga tgctcgatat cctgaaggat gcgggcgcag agcctatgtt tgtcaccatt 3186541 cctgttaacg ggaaatggta cgattacacg ggcttcccga aaaaaggacg cactgactat 3186601 tacaaaaagg taaataaaca aatcagagcg aagggcttcc aggttgctga tttctcaggg 3186661 catgaatatg acccgtattt catgaaagac accattcaca tcggctggaa aggctgggtg 3186721 tatgtcgata aagcaattga cgaattttat aaaaccggaa aagtcacttc atcctgagca 3186781 tctcatagga cgcggctgca tatttcctgc taagatttgt aatagtaaag gaatcacagc 3186841 caacttaatt aagaggtgtt acatccaatg aagatgacaa ataatacggt tttaatcaca 3186901 gggggttctg ctggcatcgg gcttgaactg gccaagcgcc tgctggaact tggcaatgaa 3186961 gttatcattt gcggacgcag cgaagcacgt cttgcagaag cgaagcagca gctcccaaac 3187021 atccatacaa agcaatgtga tgttgcagac cgttcgcagc gggaagcatt gtatgaatgg 3187081 gctttaaagg aatatccgaa cttgaatgtt ctcgtcaaca acgccggcat tcaaaaggaa 3187141 attgacttta aaaaagggac agaggagctt tttgtggacg gtgatgaaat tgaacttaat 3187201 ttccaagcgc ctgtccattt atccgccctt ttcacacctc atttgatgaa gcagcccgag 3187261 gcggcaatcg ttcaggtcac atccgggctt gcgtttaacc cgttagctgt ttatccggtg 3187321 tactgcgcaa caaaagcggc acttcactcg ttctcgctta cgctcagaca ccagctccgc 3187381 gacacgagcg tggaagtgat tgaaatggca ccgcctatgg tggacacggg cttaaaccaa 3187441 aaatcacgcg ataaacaagg cctgacgtac cggggcattt catctgaaga atatgttcaa 3187501 tatttcttgg acggcttgaa ggaaggcaaa caggagatta caaatgaacg tgttgaaggt 3187561 cttcgggatg ccactcgcgc cgattatgac aggttattcg agcaaatgaa cacgcaggag 3187621 aattaatttc tcctgctttt ttcatatgaa tttcttacaa atttgagcaa acctattgcg 3187681 attatttgtt gaaggtatac aatagaatat aattattttc aaataagttt gataatataa 3187741 acaatttaac agcagggaga ttgaccatga ctaaacaaac aattcgcgtt gaattgacat 3187801 caacaaaaaa accgaaacca gacccaaatc agctttcgtt cggaagagtg tttacagacc 3187861 acatgtttgt aatggactat gccgcagata aaggttggta cgatccaaga atcattcctt 3187921 atcaaccctt atcaatggat ccggctgcaa tggtctatca ctacggccaa accgtgtttg 3187981 aagggttaaa ggcttacgtg tcagaggatg accatgttct gcttttcaga ccggaaaaaa 3188041 atatggaacg cctgaatcaa tcaaacgacc gcctctgcat cccgcaaatt gatgaagaac 3188101 aggttcttga aggcttaaag cagcttgtcg caattgataa agactggatt ccaaatgcgg 3188161 agggcacgtc cctttacatc cgtccgttca tcatcgcaac cgagcctttc cttggtgttg 3188221 cggcatctca tacgtataag ctcttgatca ttctttctcc ggtcggctct tattacaaag 3188281 aaggcattaa gccggtcaaa atcgctgttg aaagtgaatt tgtccgtgcg gtaaaaggcg 3188341 gaacaggaaa tgccaaaacc gcaggaaact atgcttcaag cttaaaagcg cagcaggtag 3188401 ccgaagagaa aggattttct caagtactct ggctggacgg cattgagaag aaatacatcg 3188461 aagaagtcgg aagcatgaac atcttcttca aaatcaacgg tgaaatcgta acaccgatgc 3188521 tgaacgggag catcctggaa ggcattacgc gcaattcagt catcgccttg cttaagcatt 3188581 ggggccttca agtttcagaa cgaaaaattg cgatcgatga ggtcatccaa gcccataaag 3188641 acggcatcct ggaagaagcc ttcggaacag gtacagcagc tgttatttcc ccagtcggcg 3188701 agctgatctg gcaggatgaa acactttcga tcaacaacgg tgaaacagga gaaatcgcaa 3188761 aaaaactata tgacacgatt acaggcattc aaaaaggcgc tgtcgcagac gaattcggat 3188821 ggacgaccga agtcgcagcg ctgactgaaa gcaagtaaga aaaaagccgg cccattacag 3188881 gccggctttt tttacgcttc aattttgttg aaaaactgcg gcagatacgc tttgtgcgcc 3188941 tctagcattt cgtctaaaat ctgtttggcc acagtatcgg acgggacaag cgggttaatc 3189001 gtcatggcaa ggagcgcagt ttgatagtca cctgtaactg ccgcttctgc cgcgacacgt 3189061 tcaaaggatt tgatttgctg gacaaggccg cggacagaca ccggcaagtc gccgacagca 3189121 attggcttag ggccggtttt cgtcatcaca cagttcactt caactgcgga atcgtctgga 3189181 atactcgcta ttgcaccatt attgatcgtg ttcaccggct gaatgtcatg tttatcatta 3189241 taaatggagc tgattaagtt acatgctgca tcactgtagt aagctccgcc ccgtttttcc 3189301 agctgcggcg gtttgatcgc aaggtttgga tctttataaa gctcgaacag ctctttttcg 3189361 accttctgta cgacttcagc gcgggtgccc tccgtttgtg atgcttccag ttcgtgctcc 3189421 agcatctctt ttgttttaaa atagtaacgg tgatagccgc aagggatgac attgagcgct 3189481 tttaagaaat ccggttccca ttcggcgcct gagatatttt tcatcgtcat cgcgtttttc 3189541 gggtcgccca tcgcctcgat gacttgctcc ttcacactta cgccgtccaa gaaaacatcc 3189601 agcccgaata ccatatggtt cagtccggca aattggactt ctacgcggtc cacatctaca 3189661 tcaagcgctt tggctacgcc cattttgatg ccgattggaa cattgcaaag accgacgact 3189721 ttcttcaggt tggagtagcg aagcaaggct tctgttacca tgccggcagg gtttgtgaag 3189781 ttaacaagcc aagcgttcgg gcaaagctct tctatgtcct ttgcgatctc aaggatgacc 3189841 ggaattgtgc gcaatccttt aaacagacct cccgggccgt ttgtttcctg gcctatcact 3189901 ccgtatttta gcggaatgcg ctcatccttt gctcttgcct gcaaaagtcc gacgcggaat 3189961 tgggtcgtga caaagtctgc gtctttcagc gcctttctcc ggtcgagcgt aagatgaatg 3190021 tcaatcggga cgccagcttt ttcaaccatc cgtttggcga gtgtgccgac aatattcagc 3190081 ttttcttcgc cctcggggat atcgacaagc cataattcac ggacaggcag ctcatcatac 3190141 cgtttaatga acccctccac tagctcgggc gtatagcttg aacctccgcc aatcgttaca 3190201 atcttcaatc cttttgtcat atgcttgctc ccctttgctc ggtgattttt tcatataact 3190261 caatgatctc tgcagccata tccttcactg tcattgcatt cattaaatga tcctgtgcat 3190321 gaaccatcag aagcgtcatt tccgtctttt ctccgcccgc ttcattttgg atcagctctg 3190381 tctgataatg atgggctttt gacaattctt cagcagcgtc ttgaagcttt ttccgcgctt 3190441 cttctgcgtc accgcttttc gcagcggcaa tggcctccat tgcggagctc ctaccgtttc 3190501 ctccgtgaag gatgatttga aaaatgattt gttccatttc ctcattcacg cgattcactt 3190561 cctttctcta cagagccgct tctttgtcat ctgttgctgc aggcgtttgg accagctcca 3190621 gatcgttttc ttctttcagc ttctgcttat cccacattct gaagaatgga tagtagacaa 3190681 caaaggacac ggcaatatta atggcttgca tgaccgcgcc tgagactttt cctcctgtcg 3190741 ccaagtagcc tgaaaagatc ggcggcatgg tccacggcac tgcgataccc gccggtttgg 3190801 cgacaaggcc ggtgctcatt ccgatgtacg tgagtgtcac tgtgacaagc ggcgtgatga 3190861 taaacggaag taagagcatt gggttcatga cgatcggcat tccgaatata atcggttcgt 3190921 taatattgaa gatggccggg ccgaccgcaa gcttcccgag ctgcttcatt tgtttgcttc 3190981 gggcgcgcag gaacatcgtg acaaccagtg ccaatgtggc gccgcttccg ccaatattga 3191041 cccagatatc gaaaaattgc tgggtgaaaa tcttaggaag ctcctcaccg gcttggaatg 3191101 cgatccggtt ggcatccatt gcgccgtacc aaatcggtgc catgacgccg ccaacaatgt 3191161 ttgcaccgtg aaggccgcag gcccataaaa gcattttgac ggcttcggcg acaaggcttc 3191221 ctccaaggct tcctcccaga atggaaagcg gagtccccaa taaaacgctt acaatattat 3191281 gaaggctttc aaacggtgtc gcttcaacaa tcagccgggc tgcccaaatt aggaagatga 3191341 cggcaaagcc ggggattaac gcgacaaatg acttgcttac cgccggcggg acaccgtccg 3191401 gcattttgaa gactaaattg cgctggataa taaggcggta aatctctgtg gacaccattg 3191461 cgataatcat ggcgacaaat aagcctttgc ttcccatgag cgaaagcgga atcccgccgc 3191521 caaccatgat ttctttcgtc gcgccatccg gcataaacgg cacttgataa ggtgttgcta 3191581 ataaaaatgc cgcaagggaa atggctccgg ccgacaaggc atcaacaccg tatttctcgg 3191641 cgagccggta ggcaatgccg aacgcggcga caagacccat aatttcaaag gtcgcgtcga 3191701 ctgggtaggc cagtttttca gaccaggagc tgccaaacgt ttttgccata aactcagcgt 3191761 atcccgggat cgggaggttg ccaatgatga ggaaaaagga accgatgata atcaggggca 3191821 tcgtgaggat gataccatca cgcagcgcct gcaaatgacg ctgtcccgca attcttcccg 3191881 ctataggcat gaccttttct tctaagatct gattgacttt attcacatag cccgcccctc 3191941 tctatgacac atgtccaagc tgttcagctg atttcagcac ttccgcccca ttgcacgttc 3192001 cataatggac ggtattaatg acgtctaccg gaaccccctt tgactctcct aattttttga 3192061 gctgcggaag catgtaacgg acttgcggac cgagaagcaa tacatccgct ttatcgatat 3192121 gattttgtac agaatcgcct gaaactgccc aaatggtata gtcttttccc tgttcctgcg 3192181 cacttttttc catcttgctc accagtaagc tagtagacat gcctgctgca caaacgagta 3192241 atatattcat gtaaaagacc ccctagagtt tgatcaattt tgtaatgtcc tgctgttgct 3192301 atcatcatat tatgaaatcg ctttcataaa cactcagggt ttttccgcag gcaacggaaa 3192361 aaaggtatat acaggctgtc agctcagcat tttttggtca aacacatccg aaagctcttg 3192421 atatgaacgg catttgatca gctggttcat cgccgccggg tcatccaaaa tgctgccaag 3192481 cagtttatac atgctttgta aatccgcttt gttctccttt tcgacacaaa gcagacagac 3192541 aaattgaact cgctgactct cccaatcgat cggttttttg agcgtacaaa cggcccaaaa 3192601 cgttgttttc gtctgcggaa caagcgggtg cgggatggca acaagattgc caaaacacgt 3192661 tggcgacatg tcttctcttt caaaaatgga atctatgatt tcttcatcgg caaagccgca 3192721 ttcgaccact ttctgcccta aaaattgaat cacttcttct tttgagcgca gatcctcctg 3192781 aaaaaaaacg agttcttttt ttaggtagcg attggctttt tccttttcat cactcagaat 3192841 agattctatt tttgtaaagt cagttccgcc taagatggtg ttaaccttca gtactggtac 3192901 agggagctct tttttaatcg gaatggtgct gatgacaaaa tcaattgatt cgtaggacat 3192961 ttgatcaaga ctataatact cagccgttcc aagaatatcg agccgcttgc cgaaatggga 3193021 acgcagtttt tcgcgcagaa gctgggcgct tccggctccc gatgcgcata caatgataca 3193081 gcgtttcggc gggctttctg ttttttttcg ttcaatcgcg gcgccaaagt ggagagccaa 3193141 atatccaatt tcgttttcat gaatctcaat acccgtttgt tcctttatca cgattccggc 3193201 aatgatcccg gcttcaaaag cgagtggata atgttccttg atcgctgcca gcatcggatt 3193261 tcgaagattc atgccgtatc ggttgcggct gatcgccggc ttcatatgca gtgccaagcc 3193321 gattttcagc tctttgtcat gcaggatgcc aagcttcagt tcacgatcaa cagctttgat 3193381 catggcaagt gtcagctgat cggtttcctc ttctattgaa aatgtgtcct ctccgcattg 3193441 tgattgtgtc attcgttttg tgccaaggag atgcatggtg atgtaggccg tctcgtcttt 3193501 cggaaacgta acggaaagct ttgattccag ctcttttacg atggcttctg cagcctggta 3193561 ctccttttga tgcaggatat gatccatatc tttcgggaaa agagaaacat agttttccgt 3193621 tctgatccgt ttacaggcga tagcgatatg gataatgagg ttattcagtc ccatgttgga 3193681 cagagggatg cggtcgtttt tcattttttt caagatggcg gaacggatga tctcaatttc 3193741 ttcttttggc aaaatatcag ccttttcatt taaaacatct atctccgttt ctctttcatc 3193801 aacaatgtac tccgccatgc agtacctcat ctgcacctcg tccccgcgca gcttgaagcc 3193861 gtaattcgga cgtgtttcca tgacgatgcg gtaaggcagc agacgtttct ttacttcctt 3193921 taaatccgtt tggagtgtag attttgagat aaatagttct tcagcaagtt catcgagctt 3193981 gagataatgg tccgccagca gcagacgttt cataagatag gccattctct cctccggcaa 3194041 taccggcagg cccttttttt gctgaaattc atcttgcagc agtgttctga atacttgctc 3194101 gtcatcaatg cggagcttgt agccggagcc tcttacagat tgtacaaagg caccgtggcc 3194161 gcttagcaca ccttgaagtt cctttatatc attgcggact gtccgcgtcg ttacgtttaa 3194221 ttgcgcggca aaaaacgaac ttgtcaccgg ggcttcagcc gccatcagca agcgcagaat 3194281 atcacgtagt cgcccatgaa gcatgagaaa aacctcctaa ctagtagatg cagggattca 3194341 gtgaataggc agaaaggatg atgaagggat gcgaaatgta tataaattct ataatggaga 3194401 gaatggcaag tcaatgaaca tccggaggac tagagggaaa actgacctat aaaaaaacag 3194461 ccgggatcag ccggctgttc tagatgcgga catattcttt tgtttagacg ccttgcggtc 3194521 cttcatgatt tttcgaacaa tcgggtaaat gaccggcgcc catttgataa cggttttgat 3194581 catctttttc aaagctccga ttctcccttc ttttttctca accattcccc tgattgcctc 3194641 ttccttaaac atgctaacgc gacacgtacc tgtttcccgt cacccagaaa cgccatggat 3194701 aatcgcgtgc ctccccgctg ttgtcaatgc cgatgcgcgg gccggttgaa attgcttccg 3194761 gtgtgtaccc gctttcgatg taaagcggct gttccgtgat ccagcgtccg tagtcattca 3194821 tcgtgacgcc aagcgctttc gtcagctttc ctggtccgtt tgtccattcc ctcggactcc 3194881 tgcccggcct tctctcctcc attaacagct ggccttcatg cggctcaatc gccctgatta 3194941 atactgcttg cgggacatcc tcttccgccg caacgacatt cagcaatgta tgggtgtgca 3195001 tcacgtatgt atatacccgc ccagcttctg caaacatgat ctcagtccgc ttcgtccggc 3195061 ggttgttaaa gctgtgggcc gctctgtctc cagcccccat ataggcctct gtttccacaa 3195121 tatagcctga cgctgtgcct tcgtctgttt cttttacaag aaggcagccc agaagcgatg 3195181 gggcaagctc aagagcggtt ttttgataaa acgtgatggg cagcggattt ttttctctcg 3195241 tcacgaatcg acctctcctt ttaccgattt ttgtacattg taccattccc gaagcagatc 3195301 aaaaaaaacg gctgttttaa aatctttcca ttcagggaat attgttaccg ttcaaaaaag 3195361 gagggccaac cattgaaaga tgatcatcaa aacaagcagc accaatcaaa tgcccaaggg 3195421 agcgaggaag cgttttctca taagacatcc gggaaaaacg agtcagagga taccttaacg 3195481 aataggcagg ggcatcctgt tactgacaac cagaatgtga gaaccgtcgg gaatagaggg 3195541 cctacaacac ttgagaacta tgattttctc gaaaagatca gccacttcga ccgggaacgc 3195601 atcccagagc gggttgttca tgccagggga gcaggtgcac atggatattt tgaagcgtac 3195661 ggaagcttcg gagacgaacc gatttcaaca tacacaaggg ccaagctctt tcaggaaaaa 3195721 ggcaagaaaa caccggcatt tgtccgtttt tcaactgtga atcatggaaa acactcgcct 3195781 gaaacattga gagacccgcg cggttttgct gtaaagctat atacagaaga cggaaactgg 3195841 gatttggtcg gaaacaacct gaaaatcttt tttatccgcg acccgctgaa atttccggat 3195901 cttgtacacg catttcagcc tgatccagtg acaaacatcc aggatggtga acgtatcttc 3195961 gatttcattt ctcaatctcc tgaagcgaca cacatgatca ccttcttgtt ttcgccttgg 3196021 ggcattccgg ccaactaccg gcaaatgcag ggttcaggcg tacatgccta taaatgggtg 3196081 aatgaggagg gcaaggccgt tctcgtgaaa taccattttg aaccgaagca gggcatccgc 3196141 aacctgacac agaaggaagc agaagagatt caagggaaaa actttaacca tgccacacag 3196201 gatctatatg acgcgattga aaatggcgat tatccagagt gggaagtata tgctcaaatc 3196261 atgagcgatg atgagcatcc tgaactggac tttgatcctc ttgatccaac aaaactgtgg 3196321 tataaagacg atttcccatg gaaaccgatc ggcaaattgg ttctgaacaa aaatccggaa 3196381 aactaccatg cggaagtgga gcaagcttca tttggaacgg gagtgcttgt cgacgggctt 3196441 gatttttcag acgacaaatt gctccagggg cgtacgtttg cctactctga tacgcagcgc 3196501 taccgtgtag gcgcaaatta cctgcagctt ccgatcaact cgccgaaaaa gcatgtcgcc 3196561 accaaccagg aaggcgggca aatgcaatat cgggtcgata gagcagaagg acaaaacccg 3196621 cacgtcaact acgagccatc cattatgggc gggctgaagg aagcgaagca agacggaaaa 3196681 gaccatacgc cgcatgtcga aggtgatgta aagcgtgaag cgattgacag aacaaacaac 3196741 ttcggacagg ctggagaaac gtaccggaga tttactgaat ttgagcggaa cgaattgatt 3196801 acgaatttgg tgaatacgct ttctacgtgc cgaaaagaaa ttcaggatca aatgattgag 3196861 aatttcacaa aagctgatcc tgactacgga aaacgcgtag cagaagggct aaaaaaggtc 3196921 tccgaaaaca acagcaacgg gccgatcggc acaactgaaa cggaacaggc tgcaaagcag 3196981 gctgaacagg agagtcatcc gtctgatccg tattaacaac agcgaacagg gcttttttag 3197041 aagccctgtt tttttatttt tctattgaaa cgctttcaat aattgtgttg tacttggaag 3197101 gaaaggggtg gagagatacg atggaattac agcaggactt gattcctcag aaaaaaacaa 3197161 tcggcgcttt agatcacgcc gtttttttat gcatggtatt ttgtttctgg ttttcaggct 3197221 atatttacgt tcctgtattc agtctgtatt tggaggatct gcacttttca tatggcgcaa 3197281 tcggcatcat tctcggcagc tacggggtca cgcaaatcct tctgcgattc ccgctcggcc 3197341 ttttgtcaga catcctgttt tccttgcgca agcaattgtt aattgccggg ttcggctttt 3197401 ccgtcctcag cagcctgctt tttctgatgt ttgattcttt cttcttcgtg ctggccgccc 3197461 ggcttttcgc gggaatcact gcttctacgt gggtgatggc gaccatttta tacgcacatt 3197521 atttcaacaa tggcaatgca tcaaaagcaa tgggcatcat gcagtttttt accgtcatgc 3197581 ctcagtttgc cagcattgtg ttctgcgggc tcgccgcagc ccatttaggg aggcaggttc 3197641 ctttttggat ggcgctggca gcttctgccg caggtctggt gatctgctgc tttattcagg 3197701 atccgtctgc tcctcccgca aaccgtggca ccattcgtgt caatcagtac atcaaagata 3197761 cattgcggct gccaaagctg aagcttttca ccatcctgtc tatgacggcc catgccgtat 3197821 tatttatcac agtgtttggt tttacgccgc tttacatgaa tcagctcgga atgggcgacg 3197881 cggagctgct ttgggtgatg agcgcctttt tcctcccaca cgcagccgcc acattaagct 3197941 ttgtgtttct gcgctttaca agccgtatcg cttactccgt gatgctcatt agtttcgctg 3198001 tcaccggggt ctgtttgcta tatgttcctt ttttagctgc attgttcacg gtttgcatca 3198061 cacacgcctg tattgggctg gcgctcggct tcgtttttcc tctgctgcta agccatgtcg 3198121 tcgaaatcag ttctgcccgt ttaaaaatgt cagtgatggg gttttaccaa tcattttatg 3198181 cgctaggcat cttcctcggg ccccttcttg ccggaaaaat cgcacagctt atcgggcttg 3198241 cgggagtttt ttatggagcc ggttctctgg catttgccgc cttttttgtg atgctcgcgc 3198301 aaaaacgtaa catgatcaat taatagcttt cataccgccg gaagcgccac acagaaaaca 3198361 cggccagaag catgatgcac agaatggaga aagtgagtga ccatccgaaa aaatctgccc 3198421 gctctccatg aagaaggata tgctccgcct gcttgcaaat ctcagccgga agccacttcg 3198481 caccatctgg aaatagtgaa acagcaaagg aaacggctgc tgtgagcccg atcccgcaag 3198541 ccgcagctgc tccgacagac cggaatatcg tacttccggc aaggccggcg gtcacaataa 3198601 atatcaccca aagagcgtaa aggccaaggc ttgcggcaaa gcggctgaat gatgcgtcct 3198661 caaacagcag ccggacgtaa tagtaagcaa gcccgtatcc agctgcaaac gacataatgc 3198721 cgatcacgct ttggatgagc catttactca cgatataatg ggctgccgtc acaggccgcg 3198781 acataatcag cgctgttacc ccttgatttc tttcattggc tacactgccc atcacgctaa 3198841 agatgaccag agccatgcca agcgtgttga attgagaaag cgtgctgacc atcacttcag 3198901 acccggaggg catcgtaaaa ctgattttca tgccgtcagg aaggttccct ccatgtgcga 3198961 tgatttccgg catataataa atggtcagcg gctgtgtcag cccgacgatc atcatcgcaa 3199021 tcggcagcca aatcagcttg ccgcttttcc atccttccag ccactccttc tgcaatagcg 3199081 ccatcatcac cttcatgcgt gcaccacctt tagatagacg tcttctagag actccgtttt 3199141 ctgttcaaag cgggtgacgg tcaatccctt tcggatacag tcacttaata atgaccggcc 3199201 agcgtgtata tcaggcagct cgaaaaccgc ttgggacgga ttcttataga caatagctga 3199261 gacgtaaggc ttctcttcaa gccaaccttc cagcttctct ttcactgaaa gggtaaaaac 3199321 gttcgtttgc tgctgttgtt tcagctcctg taactcgcct ttccatgaaa tctcaccgtt 3199381 tttcataatc accacttgat cacacacctg ttctgcatcg tgcaaaacat gtgtagaaaa 3199441 cagaacggcc atatgctttt tcagctcccg catcatgtcc agcacctcga accgtcctgt 3199501 cggatcaagc gcagacaccg gttcatccaa tatcaaaaac ttcggtttat ggagcagtgc 3199561 ctgtgccaga ccgagtcttt gtttcatgcc tcctgaatag cccccgatcc ttttgtgcgc 3199621 cgcttcgtgc aaaccgacaa attccagcat ctcgccgatt ttctcttggc attttctctt 3199681 cgaaaggccg gacagtctcc ccgcaaatgt caaaaattca tttgcggtca tccacgaata 3199741 aaaagcagga tactgcggga ggtacccaat caaacgccga tccagctttt tctctcctaa 3199801 cagctttatg gttccagagg ttggcgaaag cagtccggcc agcatttgca gagtcgtggt 3199861 tttgccggct ccattaggtc ctaatagtgc gacacactca ttttcattca cgtgaaaact 3199921 gacattcttt acagcttcat ggtgcctgta cgatttgcat aatgattcaa tagacagcat 3199981 atcggcttac ctttgctttc tgccgacggt gaaaaataaa atcggcccga taatattgat 3200041 acatacgatg attgcagccc acatccactt tggcccgttc gtccgctctt cttttataca 3200101 gctgataagg gcaaacaccg ccaaagccag ctgtaataca atcagcggca aaatcatttc 3200161 ccaagaaata ttcattgctt gatccccctt ttcttccgat ccggcctaat gacaaaaaag 3200221 taataacaaa tcagaggcat cggtgcttga atcaatccga caatccccca aacccatgcc 3200281 atgtgattac gttttttcgc atcaataaat aaaaagattc cctgcgccaa tacgatgaga 3200341 caagccgcaa ccgttatgat aatttctgtt tgtgtcatcc gcgtttcacc tcgcattcgc 3200401 cgagatgcct ttttttctca gccgcaatca aaatcggcag caccgcaagc acacaaacct 3200461 gaagcacaat aaacacagca ggagcttgag tgaaagctaa gattgcagca ctcacaacca 3200521 tcagcgcgca gaatacaaat aaaatgatct cttgaagaag tttttttctg tattcagctt 3200581 tcatttgtga cagctggtga agcagttctt tttgattcgg tatagaggga ttggctgttt 3200641 gatcaatttt tttccattct gactttaaat gatcagaaag cttttcttta ttcatcatcc 3200701 cactcctttc tgatttgctg gagcccttta tgaactctgg actttacagt gccttctttg 3200761 atttgaagca tcaccccgat ttcagcgtag gtatagccgt agtaatgcct taataaaacc 3200821 ggtgtgcgca gtttagggtc cagctttgaa aacagatcga gcgtttcgct ccactctgcc 3200881 cctttcgccg acacgtccca cttgatcttg cggattgttt cctccgtaac tgtctgattc 3200941 cgtttccatt ctctctttct ctttttctgg tgatcgagat agagccgcga tgcaatggag 3201001 atcagccatg tggagaattt tgaacggccc tgaaagcttc ttaaatggat gtaccctttc 3201061 agaaaggttt cctgaacaag ttcctcgctg agatcggggt gaagggaaag ctttaacaag 3201121 tatttatata agaaagaata gtgatagtgg aaaagggctg taaacgcctc gtcgtttccc 3201181 tctttcgcct gctggatcag ccgctgttct tcttgtgtat ccaatgaccg tgatcccccc 3201241 ttttttgttt ttctgcctta tgagacgaca ccggattcaa aagcgttcat cttttttaca 3201301 attcttttca gccattgaca gatcaggctt cccggccgtt tggctgcata tccttatttg 3201361 taaaccccct tatagtctgt taagctatga ctttatgtcg atttcaaaaa aacatccaat 3201421 atggaggacg atgcattgaa agtagaaagg cgaacgattg aatatattcc gaatgaagaa 3201481 agacatggta aagcgaaaga tttatttccc gtatggttcg gggctaatat gcatatcacc 3201541 acgttagtga ccggcacgat tcccgttgca atgggactta atctgttttg gagtgttgcc 3201601 gctattattt gcggaacctt aatcggtgcc atatttatgg cttctcattc cgcgcaaggc 3201661 cctcagctag gcatcccgca aatgattcaa agccgtgccc aattcggcgt aatcggagcg 3201721 attcttcccc tcttcttagt catgtttatc taccttggtt tcttcgcaag cagcacgatt 3201781 ctggcggccg gaaccttaag cagctttgtt cccatcccgg gatcatggag cattataggc 3201841 ttaagtgccg tatgtttttt actcaccatt ttcggccatg atttgattca caaaatgcaa 3201901 aaaatccttt cttggacctc ttttgctgta ttttttgctg caacgattct catttttcaa 3201961 ttgccgattc cggcaggcag ctggataccc ggagcgattg atctgccaat tttcctagtg 3202021 gcagtcagcg cagttgcgac gtggcagctt gcctacgcgc cgtatgttgc cgattattca 3202081 agatatctgc cagttaaaac accggcttca aaaacatttt ggtacagcta tgcaggtaca 3202141 tctgtcagct ccatctggat gatgctgctc ggcgcattgc tgacaacctc acttcctgac 3202201 tttacggcaa actcaggcag ccagattgtc caattgttcg gtcccttctc gtttattatg 3202261 ctgatcattg tgctatttgg gcaaatggca atcaatgttt ttaacctgta tggggctttc 3202321 atgtccacga caacaacgct ggagccgttt ctgaaattaa aagtcacgcc caaagtcaga 3202381 atcatcatga tcctgggtgt cacgcttgtc ggcacagtct taagcctact gggacagagc 3202441 aattttatgg aactgttttt gaattttatc tttttcatca gttatttctt aattccgtgg 3202501 acggcaatca atttagtcga ttactacttc gtccgccacg gaaagtatca agtcaaagcc 3202561 atgttcgacg taaacgggcc ttatggaaag gtcaattgga tcaccacaat tgcgttcgtt 3202621 ctgtctatct tgctggaaat tccgtttatc aacacaagct tttacatcgg accgcttgcc 3202681 aaaatgtttg gcggcggaga catcgcatgg attatcggct tggccgtgcc ttctgtgctt 3202741 tactatgtat taatgaaacc gcgtctgaaa aaacgggcgg ggtatcaaga aaagctgtct 3202801 tctctctgaa gacagctttt ttatcattca aatcgtttcc acacgcgggg caggatgtca 3202861 gatagctcat gagcgagcaa cgtatgagcg gagtgctcgt ccgtccagag ctcggcgcac 3202921 gcaccatgca aatagaccgc gtttaatacg gcgtgctttg gatcttcatg gcagcagagc 3202981 atccccaata tcatgcccgt cagcgtgtca ccggttccgc ccttggcgag cgccccgttt 3203041 ccggttggat tgagccagca gtctccatca ggaaacgcga tgacggtttg gtttcctttt 3203101 aacacaatga cagtctgcag ctgagccgcc cattcctttg catattccgc tctttttttc 3203161 tgcaattcgt tcacgggcac ccctgtcatt cggaaaaact cgcccgggtg cggcgtgagg 3203221 atgacggggc cctcccgttt cggatatgtg cgcttcgcca gcgctccggc atccaaaata 3203281 acaggacaat cagccgtaag cacatgatcg actgcctgct gtacgctttc cgtttgcgga 3203341 aggcccggtc cgatggcaat ggcccggtac gtctcttcaa gctgagcatc cgccgccttt 3203401 ttccagccgt cacgccaata ggtcgcctcg ggcaaaacag gaacaattag cgggattacg 3203461 ttttctgatg taccgatgac aagcttgccg agaccgctcc gcatggcccc aagccctgca 3203521 agcagcgctg ctcccggcat gtcgtcactt ccagccagca gcaaagccgt accgtacgtg 3203581 cctttatggc tctccgcatc tctttcagga agcgtggccc ttacatgctc ttccgtccaa 3203641 aatggaacat tcatctctat ccctcctctg ctttcttttc ctatttttcc tgtccctttt 3203701 ctttttcaaa caaaaaagac agccttttag ggctgtcttt tattttacag gaacatcaag 3203761 gtgatacagg cggcgatatc gttcgtttgc cgccagcagc tcctcatggg ttccttccat 3203821 ttctgttttg ccgttttcga gaaatacgat tttatcggct gcttccactc ccgcgagatg 3203881 gtgtgtaatc cataaaatcg tttttccttt cagcacctca aacaccgttt ccatcaattc 3203941 acgttcggta ataggatcga ggccgactgt tggctcatcg aggatgatga tcggtgtatc 3204001 ctgcagcaaa atcctcgcaa gtgcgatccg ctggcgctct ccaccggaaa aacggatgcc 3204061 ggtttcttgt acagaggtat gatatccgtc aggcaatgac tcaatgtagt catgcagctt 3204121 gacctgcttt gcggcgcggc gcacatcctc gtcgcttgct tctccgtttc cgagcctgat 3204181 gttgttcaaa atgcttgtat caaacaggtg cggtttttga tttaacacgg ccaccgcatc 3204241 cgcaatctga tcctttaaca gcgctgtctc cactccgttt aacgtcacag aaccggagtc 3204301 cggtttcaag gcgccttcga ttaatgcaag cgatgttgat ttcccagagc cgcttcggcc 3204361 gagcagcgcc attttttctc cttggcgcag cgtaaaggaa aagttgtgca gcacttggct 3204421 gctgttgtca taagaaaacg tcacatcacg aaaggccaag gtgacatctt gaagatcgag 3204481 aatttgatcc cctgattcag tttgtgacgc ctccggctga ggagccacat tgttcatgcg 3204541 tctgatagaa tcctgatagc ccggcacttc gcctaaggca tccgaaagcg gcaaaaaggc 3204601 ttccgtcaac ggaaacacca ctagcacaaa agcggcaatc atcgttttag cgagctcgcc 3204661 gtccgcttgc tgtcccgctg tccaaaacag catcagcaaa ataaggccag cgacaaggca 3204721 ttgcgcagca aagtcccgcc atcttgtaaa gcgttgtttt ttccgttcaa gctcaaacca 3204781 atcacgttcc tctttttcat aagcatcaat aaaagcatgc cggcgtccgc tgaacatcca 3204841 gtcgctgaca cccatcacag catctgtcag acggctgtac agcacattcc gtccgctttt 3204901 cagcttcgca ttcttcgctc tcgtcacgag caaagacaca accggaaaca atacaacaag 3204961 aacaaacaaa tacagcgcaa gcaatatggc aaacggccaa gagaagaagc cgagcgctat 3205021 cactgacaca gcatacagga gcaaggctga gatcgcagga aaaatcgttt ttaagaaagc 3205081 atcctgcaaa tgctcaatat cctcagacaa aatgccgagc atatcccccg tgcgaaaacg 3205141 ggaacgcagc atcaaagcac ccggctcaag catattgtaa aggcggacgc gcatgtcaga 3205201 tacgattttc aaaatgatgt gatggccgac gagccgttcc acatatcgcg acacagagcg 3205261 cgcaatccca aaggtgcgca cagcgacaat cggcacataa atgagcagaa tgttttccgg 3205321 ccttgtcgcc gctttagaaa tcaaaaaacc tgaggtgaac atgagaaaag cagcagaaaa 3205381 aatcgtcacc gcacccaaaa agataaccag aacgaacagg cgggcatttt gcttgatata 3205441 cggcaaaatc cattcttctt tcttcatgct ctttccccca gttgtgcctt cacgagtttg 3205501 gtatacacac cgtttttctc cagcagttca ttgtgagtcc caatttccgc aaccctgccc 3205561 ccgtcaagca cgataatttc gtccatatcg agcatccagt gaaggcggtg agtcgcgaga 3205621 aagacgagct tatcctcaaa taaatccagc atcgtttctt ttatttcata ttctgtttcg 3205681 atatcaagat gggcggtcgg ctcatccagc agcaggatcg gacggtttcc caaaaaggcg 3205741 cgggccagcg cgacacgctg tgcctggccg ccgctgagcg cccggccgcc ttccccgatc 3205801 cgcccctcta atccgtcagg aaggttgttc accagctccg tcagtcccgc tgaggcagca 3205861 gcacgtgttg tatcctctgc cgaagcgctt ggatggtaga agcgaatgtt gttgccaagc 3205921 gtatcatcaa aaatgtacgg atgctgggga atgtaaagaa ggttcttctg ccagctgccg 3205981 tcctgcaaat gggaccggct tgtaccatta acctcaatca tcccgccatc cggctctaaa 3206041 aatccgccga gaatatcaat taatgttgat tttccggcgc cgcttgcacc gataatgccg 3206101 atttttttct tgcctttgaa tgagagatga atatcagaca ccgaacggcc gactgacacg 3206161 cctgacagct tcagctcatc ctgatcggac caagcttcga gctgaagcgg cgtctcttct 3206221 ttaaaaccag gctgcgacaa aatctcttga atggtttttc ctgcttcctg gccgttcagc 3206281 gttgcatgat aatcattccc cacttcccgc accggcaaaa aatactcagg cgccagaata 3206341 agcgccgtta aagcagggcc aagcaaaata tcgccgtcaa tgaggcgcag gcccagaaat 3206401 actgcgactg tcgccaccga cagcatcgtg aaaaaatcga gggcgaatga tgacaaaaac 3206461 gccacccgga gtgtgctcat cgttgccttg cgataccgct cactcacata gaaaatattt 3206521 ttgctgtgtg acttgctcaa acctaggaaa cgcaatgtct ccagcccgcg aagagaatca 3206581 acaaaatgat tggaaagtct ctgataggat ttccactgac gatccgcttt tctctgcgcg 3206641 acaaggccga ggagaatcat aaagatgatc agaatcggca tagcagcgac taaaatgatg 3206701 gctgatgtcc gatcctgaaa aaacacataa atgacaactg ccgcaggcac aatcgccatg 3206761 ctgaccattt tcggcagaaa cagctccagg tagcggcgga actggctgat gccttccatc 3206821 gccagcgtca ccatttgccc cgtcccctct ttctttgcaa agcgggggcc taatcggaac 3206881 agctgatcaa gaaaactttt cctcaaatct gctcctgtcc gggcggcgta ttgatagacg 3206941 attttctgtc gcgccaccgt catcccgtgc cgggcgataa aagcgatgag gaaaaagccg 3207001 atcaccggta aaagggaggt aatgcccttc ccgttgaaca gtccggttac ggcctcactc 3207061 agccactctg cctgcataat aatggcggct gtctgaatca acgttaaaca agtaatcaag 3207121 gtgagaatcc gcttcattcc tttatatcga aacaggtctt ttcccattaa taagtcatag 3207181 gctccttatg gctgacgcgc ttccggaaga cataatagct ccagatctgg ctgccgatga 3207241 cgaacggcaa tagcgttaat gctgcaattg acatgacttt aagcgaataa tctccagaag 3207301 aagcgttagc tactgttaaa tcgtatgcgc tatgaagcga gctgaccatt acacgaggga 3207361 atagggaaat aaagatcatt cccacggtca gcgccagacc agcgcctgtc atcccaaatg 3207421 tccagccgtc ttttttctta cgaataaata cagccgcgag cataaagcag atgacaatca 3207481 aaacagcgag cggaatggta atctcgccgc ggcgtgtaaa catgtctgtc tgatacgcag 3207541 aaagggccgc gaaggcaaga accgctacaa aaacaacacc cattatcttt tgcgccattt 3207601 tccgggcgcg gttttgcaaa tcaccaatcg tacgcagcgt gataaacatt aatccatgct 3207661 ggaagcaaag aagcgttacc gtcacaccgc caagtataga atatacattg atataatcag 3207721 atacatgtgc gtgaatgttc atgtcggcat caatcggcat cccgcggaat aatgtcgtga 3207781 acagcacacc aagcacaaac ggaggaatta gactgccgaa aaaaacgacc cagtcccaaa 3207841 cctttaccca ttttaaatga tccaccttgc cgcggaactc aaacgcgacc ccgcggccca 3207901 ttaacgcaag cagcactatg acaaacggaa tgtaataacc gctcagcatc gttgcatacc 3207961 agtttgggaa tgccgcgaaa atggcgcctg cgccagtcaa aagccacact tcattcgcgt 3208021 cccagaacgg cccgatcgtg ttgatcagca ctctgcgttc taattcatta tggccaagaa 3208081 aacgggtcgc catgccgacc ccgaaatcaa agccttccaa aaagaagaat cctacaaaca 3208141 atacagcaac gagtataaac caaagatcat gaagagatgc catggtatac ctcctgacta 3208201 aatggatctg ttgatacagg cacatcatga tgattatcat gctccgcacc ttttttaatc 3208261 tcacggataa acaagaagac aagcagtgca ccaagaatca tgtacatcac accgaatgcg 3208321 atgattgaga ataacaagga acccgctgtt acgttaggcg acacagattg agcggttgtc 3208381 attaacccca taaccgtcca aggctgacgt ccgatttctg tcataatcca gcccgcggag 3208441 tttgcaagaa acgggaagga aatcaacgcg atcatgatgc gcaaatacca tttgctgttt 3208501 tcaagctttt tacggcggtt taaccaaagg ccgcctaacg cagcaagaat catgacaaca 3208561 cctgctccta ccatgatgcg gaagctccag aatgtcgttt tcactggcgg aatgtagtcg 3208621 ccttttccgt atattttttc gtactcagcc tgaagggttt tcatcccttt gacacttccg 3208681 ctgaatttct gataagccaa gtagctcaag gcataaggaa ctttgatttc atttgagctt 3208741 ttttcatttt ttgtatcgat cgtcgcaaaa gcggtccaag cagcagggtc accgctgtct 3208801 tcccataggc cttcactggc agccattttc atcggctgtg attccatcaa gtgctcagcc 3208861 tgcatgtgtc cgctaaggcc gacgccaaga ccggcacaaa gaccgacgat cattgcgagt 3208921 ttaaaagatt gcttaaagaa cggcacttct tttttcttca gcagtttaaa agcactcact 3208981 ccggcaataa agaaagctcc agtggcaagc gcaccgaaaa taacgtgcgg gaattcaacc 3209041 caaagctgag ggtttgtaat caacgcgcca aaatcattca tttccgcgcg gccgtttttg 3209101 atcgtaaagc cgaccggctc ctgcataaag gagtttgctg ttaaaatcca gaaagatgac 3209161 atgatcgttc cgaatgatac gagccatatg cagagcgcgt gaattttctt cggcaggcgg 3209221 tcccagccaa aaatccataa tccgataaaa atagattcca tgaaaaacgc caataatgct 3209281 tcaatcgcaa gcggagcgcc aaatacatct ccgacaaaac gggagtaatc tgaccagttc 3209341 agtccaaact ggaattcttg caaaatcccc gttacaacac cgactgcgaa atttattaag 3209401 aataagtgtc cccaaaactt tgccattttg agatacagct catttttctt tacaagataa 3209461 agagtctcca tcaacgcaac cataaacaca agcccgatag acatcggcac aaacaagaag 3209521 tgaaacaacg ttgttgatgc aaattgtatg cgggctaata ccaattcact catgctttct 3209581 cctccatttc cggttaaaac tgttaatttg ctcactactt cacaaataga accgagactt 3209641 tgatcagtaa ttcacaaaat agacgaaaaa aatattgctc aatatttcac aaatgtgtca 3209701 aaaagtcatc caatatgatg caagattgcc agactgacca aatgacacaa tctctgactg 3209761 gttcatatta agtactttac aacgattcat ttcaaaaata aagcctaaaa tacctaaaaa 3209821 gtcccgcact atgtgacgga tttttgtcta ttttgttgct tatttatgtc ggctgctagg 3209881 ataaatgacc ctttattatc gtacatcaac acatcgttcc ttgcgaacaa aatgcttgcc 3209941 cccgccccag cactcgagtc tcagcattcc gtcttaaacc gattttagtc agaatgcctc 3210001 ttttcatttg aaccggtaag aggagaaaag ttgaatagta aatttttaat atattaataa 3210061 tttcaatttt ttagtatact taacatagtg aacaatttca ctgcatcaag aataggggag 3210121 gtttttcaat gggagagctt caaacacaca tgcaattgca aacggataca attcacgaag 3210181 gggttcgaaa agagaattgg tttgcgaaag ccatgaatat aaaagtaggc atcataccgc 3210241 ttcctgtgta tgccttgctg tttatattaa tcactgtttt tgttatgcat cacgatgtaa 3210301 aaagtgacat tttgacatcc attgccgtca tggcgttttt cgggtttacc tttgcccaaa 3210361 tcggcaaatc gataccgatt gttcgttcta tcggcggccc ggccatccta gctactttta 3210421 ttccgtccgc tgtcgtgtac tatcacctgc tgcctaatga tatcgtcaaa tccaccacag 3210481 aatttacaga aaactcaaac tttctatatt tgtttatcgc cggtattgtc gtcggaagca 3210541 ttctcggcat gaaaagagaa acactcgtaa aagcattcat gaaaatcttt attccgctta 3210601 ttgtcggttc tgtcacagcc gctattgtcg gactggctgt cgggacattg ctcggactcg 3210661 gatttcagca taccctgctg tacattgtca ttccgatcat ggctggagga gtcggagaag 3210721 gcgctatccc gctgtccatc ggatattctg acatcatgcc catttctcaa ggggaagcgt 3210781 ttgcacttgt tctgccatcg attatgctgg gcagcttgtg cgcgattatt ctagcgggat 3210841 tgctgaaccg aatcggaaag aaaaaaccgg aatggacagg caacggcaaa gtggaccgct 3210901 ccgaagaaga gtcccctgcg ctggaggaat ctcaaagcgg acagcaaatg ttcaaccttt 3210961 ctttatttgc gtcaggcggt atccttgctg tttctttata cttagtcggc atgctcgctc 3211021 acgatttttt cggttttccg gcacccgttg ccatgctgtt actggctgtt ctaatcaagc 3211081 tgttcagatt ggtgcctgcc tcaattgaaa atggcgcgtt tggagtgtcc cgcttctttt 3211141 caacagctgt gacctacccg cttctctttg cgattggggt atccatgacg ccgtgggaca 3211201 agcttgtcgc cgcttttaac ctcagcaata ttatcacgat tctgtctgtc gttgtgacca 3211261 tgatggccgt tggcttcttc actggaaaat ggctgaacat gtatccgatt gaaaccgcca 3211321 ttattaatgc atgccattct gggcaaggcg gcacgggtga cgttgccatt ttaagcgccg 3211381 ctgaaaggct tgagctaatg cctttcgccc aggtgtctac ccgcatcggg ggcgcgatta 3211441 cagtatcctt aaccttattg ctgctgcacc agttttattg atccccgcaa gcaagttctt 3211501 cgtcaaacga aagagcttgc ttttttgcat gtccatgttt ttgcaagttc ccatcccatg 3211561 ctatagtaat agttggaaat actagataga aaggaatctg gcatgcctat gggaactcat 3211621 ctatttctct ttatgcttct cgggctggga ttttatttga tatcagccct agctgcaaaa 3211681 ctcattccgg ccatagactt ctggattgat attgttctat gggtcggcgc tgcggcttac 3211741 atcttctctc atctctcatt catggacggc attgtctcac tcgcgacaat gttctactgc 3211801 tattggaccg caatggatct cattgtttca gagcgtgtgg aaaaaccttc gggagactgg 3211861 caggaaatcg agcttgccaa aaacaaaaca cgcctcctgt cagacattac gctgaccgcc 3211921 attgtgtttg caggggctgt catttttttc atctatggac ctgacacaag ccctctcaaa 3211981 tatgtgatcc ttctcggaat gatctccggc ggaggggcac ttgtgaagcg aatactgaat 3212041 gtttttagcg taaaggtttt ttattcagca gccttagaaa aattgcatat cagctcacac 3212101 tatgaaaccc gtacataccc gctttccgat ttgaagaaca ttcagcttga atcaacagca 3212161 gatctcttaa agctccatcc gcttctgacg atgtattcat cccgtttaga tttgacaaca 3212221 agctttcagc aagtcattaa actgtctctt cccggcgaaa cactgtttct gacggtgaag 3212281 gaaccgcaaa aatggaaaac aattcttcag gaatacacag atgcagaaaa caatgtggac 3212341 aatgtgattt ctgttttgcc gttttatcat cgaaaaaatg tgaagcggct gctcggtaag 3212401 ctttattttg ccgccagcgt aaaaggggta tccgcttacg ccttattggt gctcgcgtta 3212461 tacgcattac acgcctctcc atgggtcatg gctgttgccg taatcctata ttgggtattc 3212521 aacatgtata tgtcagaccg tgtgttgcgg gcggcgatgg acgccaagtc ttgtcatcat 3212581 ccgcatgtac aggccgcggc cgataagatt ttcagatcgg ccggcatttc ccatgtccgc 3212641 atatacgaaa cggagagtga tgattacaac ggaatggcag taggcatgaa tgtcgggagg 3212701 tcaatggtca tcctgacaag cgccacacta acacttccac agcgtgtcat tgaaggcatt 3212761 ctggcccatg aggcgattca tatcaaaaaa cgtgacgttc tgtcatcaca gcttttgcgt 3212821 tttctatatc ttggagctgt cgtggggatt ttcctcttgt ttgagcagca tatcacccat 3212881 cccgaggccc acaaaattgc gctttgggct ttcattatgg caatcattat cctattccag 3212941 ctctatcaat ccttttgttc acaatggatg gaggtgcgtg ctgacaacct tggcgcatca 3213001 ttgctggacg gcggttacaa acaaatggct gaagccttga gaatcttggc ggttcggcaa 3213061 gatgaggata tacagaaaca aagtgcctat agctctgaag caggtgaaga cgagcttcaa 3213121 attgattctc tcacccgtga taaaagctgg tttttcagat tgattgattt tcagttcgct 3213181 cctcatcctc ctatgtattg gcgtgtcggc actttattgt caaacaaagg acatggggtg 3213241 ctaaagcgct ggctcagaga ccgactgaaa gaatcgatca ctttgaaatg aaaccggtca 3213301 gcgtttcatc cgtataacag atatggtgaa aaaagggagt gacgcgaagt gattgtgatc 3213361 atcttattgt ttatatctat tattgttttt ctttcagtca ttcagccgca gccctcgaaa 3213421 aacaaaagcc gccagcaggc ggacagcggg tatttcggtt attcagatca tagctcacac 3213481 catgatggat gcagcagtga cggaggtttc agcgattccg gctgtggcgg cggagggggc 3213541 ggcgattaaa cgccgccttt ttttatttca ttgattcgat gtacgcacca aaagccgagc 3213601 ctgacatgcc tggggacacg cgcacacgat ggagggcata cattccctgg tctctcgaag 3213661 ccgcgcccgg ttctgtcgtc acgcccattt gatagcctgt tttttcagcg gccttcagcg 3213721 tctcctcatt gtagcgccct accggatagc tgatgatggt ggtttgctga tgaaacatgt 3213781 tgtcgaacag ctttttcgaa tcagccatct cactttgctg ctgttgaggc gttaatccgt 3213841 tcagctcaag gtggtcaatc gtatggcttt caatcgatat gccgtgctgt gccatttcct 3213901 tcatttgttc ctctgtcaga tggtgcttat gtccgatcga tttgccgatc ataaaaatcg 3213961 ttgccttcat cccgtacttt ttcagcaccg gatacgcatc ttgataattg tcggtgtacc 3214021 cgtcatcaaa tgtgatcagc acgcacttct cactcggttt tttatcctgc gtcagcatga 3214081 gagatgcctc tttcggcgtt aatgtctgat agccgttatc atgaagccac ttcatatgcg 3214141 cctcgaattc tttctttggc acacggaggc tgtttcctga agaaatgctg tggtacatca 3214201 aaatcggcag ctttgccggt ttctctgttt tgatccatgc ggatgtatcg tcttcttttt 3214261 tctgaacttg tactgccttt ttttccggtt tcttttgttc cgcttttggc atcggctgct 3214321 ctgcattcgc ctcttgatca gcacaagccg caagagccaa acagctgccc aaaagaaaga 3214381 tgcttaaaaa caatcgtttc atcgttctcc tgctttctgt ctatttcttc ctcctttttc 3214441 atcggtttga ttctgagatt ttcaatagca aaaaaccgga catgtctcca tgtccggttt 3214501 ttttgatctt atcggattct cacttctgtc tcactgtcaa agaaatggcc tttattcata 3214561 tcaaatgcaa ccgtcagctc atcgcccgat tgaatatcga ggcgggcgtc gatccgcgca 3214621 ataaagtctt ggttgtctat ctgcgaataa atcataattt cagaaccgag cagctctgca 3214681 acattaattt tcgccttaat cgaagagttc ttatatgatt ccacgacaat caattcatca 3214741 tgtatatcct caggacggat gccgaagatg acctctttgc cgatgtagcc tttttcacgc 3214801 agcactttca tttttccttc cgggacggtt aatgccgcag aaccgatttt gattaagcca 3214861 tccgtgagct ttcctttgaa aaaattcatc gccggtgatc cgataaaccc gccgacaaag 3214921 acgttttcag ggaattcata tacatccttc ggcgtcccga tctgctgaat tttcccatct 3214981 ttcatgacta caatccgtgt cgccattgtc agcgcttctg tctggtcatg cgtcacataa 3215041 atcgttgtag tctgcaatct ctggtggagc ttaatgattt ccgcccgcat ttgcaccctc 3215101 agcttcgcgt ccaggtttga caaaggctca tccatcagga acacctttgc atcccgcacg 3215161 attgcccggc ccagcgcaac ccgctgtctc tgtccgcctg acagcgcttt cggtttacgg 3215221 tgcaaatatt cctcaagccc gagaatttta gcggcttctt cgactctttt tttgatttca 3215281 ggcttcggca ttttccgaag cttgagcccg aacgcgatat tatcgtagac cgtcatatgc 3215341 ggataaagcg cgtagttctg aaataccatc gcgatatccc tgtcctttgg cgctacatca 3215401 ttgacccgtt ttccttcaat ataaaaatca cctttcgaaa tttcttcaag tcctgcgacc 3215461 attcgcagcg tcgttgattt cccgcagccg gacgggccga cgaatacgat aaattcctta 3215521 tcggcaatat gaaggttaaa gtcatcaacc gccggttcct tctgatcata aaatttataa 3215581 atgtgctcca tccgcaattc agccatctaa catccccctt tgttattgta aacgctttct 3215641 tatattgagt gtaacagcaa ttccctctcg ctaaaatggg cagcgttcat aaaatcaccc 3215701 agccattttt cgtgcatatt tccaatttat tctgaacttt cattttgcag gcagataaaa 3215761 taggcaagaa gcgcgccttt gtacgatttg atatctatcc ctgaccgctc aataaattta 3215821 tcaatccgat attgcaggct gttgcgatgc agatgcagct ttttcgctgt taatgtgacg 3215881 tttgagttgt tttcaataaa cagcttaatg gtcttcctta gctcagattc acttccaaat 3215941 aaaagctcag cttcttcaga gagcagtgtt tccagttttt ctttttctgt ttctaataat 3216001 agaaaaggaa agatcatctc aaaggtcaca ctctgcacct gaggcagccg tttttcagca 3216061 aacaggaaat acgcctgttc acgagcgtaa tgttttcgca gacactcatc cggctcgtaa 3216121 aatcttccgg cgtaaaaacg gacactgaag tagaaatcac tttcaagaac cttagcgagc 3216181 gattccagtt cgtccttctc cgccgccgct tcactttcct gctcgacaat cacacctctg 3216241 tcctcatgga tccacacaat cacaaaagac accggccaaa aatggcgaac cgcttccgta 3216301 aaggacgtcc tttctatttt gccgaataaa tgaaagtgaa caaatctcgt ccgtttcttt 3216361 atatacgccg gcaattcccc tctggaaaaa aggaacgaaa accacttgtt ttcctcaggt 3216421 gatttcatag acagttgatt gccctcatcc gcaggcgtca aaaatgactg cagcaccaat 3216481 acttcttttt cactgatctc tgttttcgga atggagatat atctctgatt gctctcatca 3216541 aaaaaacata gacagccttc ccttatgcaa agctcctcag acacaatcga accgggataa 3216601 atagccagca gcgatttcat agagtctcct ctcttatgta aggatctgta tattcagtat 3216661 aaggcgaaac acacatgttc tccactaaaa aagagtatat ccggtataga tagacgagaa 3216721 actgaaaggg aaacctcatt cgtttacata ttggcttcag cggaaataga agaagacatg 3216781 caggaccaaa ggagggtcat cttatgagtt tcgaaacgtt aaacaaaagt tttatcaacg 3216841 gaaaatggac tgggggagaa agcggacgta cggaggacat tttgaatccg tatgaccagt 3216901 ctgtgatcac aacagcatct ttggcaacgg gcaaacagct tgaggatgcg tttgacattg 3216961 cacagaaagc ccaaaaagag tgggccaaga gcacgacgga agaccgaaaa gccgtgctgc 3217021 aaaaagcgcg cggctattta cacgaaaacc gtgatgacat cattatgatg atcgcccgcg 3217081 aaactggcgg aacgatcatt aaatcaacaa tcgagctgga acaaacgatt gcgattttag 3217141 atgaagccat gacgtatact ggtgaattag gcggcgtcaa agaggtgcca tccgacattg 3217201 aagggaaaac caataagatt taccgccttc cgctaggtgt catttcatcg atttctccat 3217261 ttaatttccc aatgaatcta tccatgagat ccattgcgcc cgcaattgcg ctgggtaaca 3217321 gcgttgttca caagcctgat atccaaactg ctatttccgg cgggaccatc attgcgaaag 3217381 cgtttgaaca cgccggtctt cctgccggtg tccttaacgt catgctgacg gatgtaaagg 3217441 aaatcgggga cggcatgctc accaatccaa tcccgagatt aatcagcttt acagggtcaa 3217501 cagcagtcgg gcgccacatc ggtgaaatcg ccggtcgcgc cttcaaacga atggcacttg 3217561 agctcggcgg caacaatcca tttgccgttc tttcagatgc ggatgtcgat cgtgctgtgg 3217621 atgccgcgat tttcggaaaa tttattcacc agggacaaat ctgtatgatt atcaacagga 3217681 tcatcgttca tcaagatgta tacgatgagt ttgtagaaaa attcaccgcc cgtgtcaaac 3217741 agcttccgta cggcgatcaa accgatccga aaaccgttgt cggcccgctg atcaacgagc 3217801 gccaaatcga gaaagcgctg gagatcattg agcaggcaaa gacagacggc attgagcttg 3217861 cggttgaagg aaaacgcgtc ggaaacgtgc tgacgccgta cgtctttgtc ggtgcggaca 3217921 acaacagcaa aattgcccaa acggagctgt ttgccccaat cgcaaccatt attaaagctg 3217981 gcagcgacca ggaagcgatt gacatggcaa atgatactga atacggcctc agctctgcgg 3218041 ttttcacttc tgatttagaa aaaggcgaaa agttcgccct gcaaattgac agcggcatga 3218101 cccatgtcaa cgaccagtcc gtcaatgatt cgccgaatat tgcctttggc ggaaacaaag 3218161 caagcggtgt cggccgtttc ggcaatccgt gggtcgtcga ggaatttacc gtgacgaaat 3218221 ggatttcgat acagaagcaa taccgcaaat atccgttcta aatgaaaaaa tccctctgtt 3218281 tcaagtacag agggattttt ctttatttag atatatccac aaacccttcg ccaaacacat 3218341 cgcgtacgtc atgtacgatc acaaacgctt ttttgtcgca gcttctaatg atttttttca 3218401 gcatagacag ctcctgtttg ttaatgacga tatacaaaat ctcttttgac tggcccgtat 3218461 aatttccctt ccctgataaa atcgtcacgc cccgatccat caaggtattt acctgctctg 3218521 caatctcact cttattttct gaaatgaccg taatggcttt tttcgtattc aaaccttcaa 3218581 taatgaagtc catcactttg gtaccgatat acagcatcac gatcgtaaac atcatttttt 3218641 ctgcaccaat aataaaataa gagctaaata ctacgattaa atcaaaaaac aagagtgcat 3218701 agctgatatt ccagtctaaa tatttattag caattctggc cagaatcgcg gaaccggccg 3218761 tcgtcccgcc gacccggata atcatgccga tcccgactcc ggcaaataca cctgcgaaaa 3218821 tcgtattaat gatcaattca tcagacggaa tgctccaccc atgtgtcaga tgaagaaaaa 3218881 gcgaatttgc cgcaaccgca atgatcgtat aaaccgttgt ttttccatca agaaacttgt 3218941 agccgattaa aagcaaaaac gcatttaaga taaagttcgt gacaccagga gaccattgaa 3219001 acagataata caaaatcagc gtaatcccag tgactccgcc ttccccaaga tcattgggaa 3219061 tcgcaaataa attaaccgca agcgcgaaga aaaaagcgcc aatcacaagc ataagtacat 3219121 ccagcattct ctttttcatc acgaaaacac tccttttcat tgttctgttc tagcaaataa 3219181 aaaaacccag gagaacgctc tcgaaaaaga gcagaaactc ctgggctttt atcccaccgt 3219241 gtcataacag ccaagctgct atgtgttttc tctcggtcac agtccaattt gcattgcgga 3219301 accctagaaa accactgttt ttatcatatc cttttcactt tccaatatta gcattataag 3219361 ggacggttcg aattggttca aggggtattt gcggagtttt catcagataa gctggaaaaa 3219421 aatacgattt atctattaaa aaagaacaga tataaccgat aagaaaaaaa gcatatattt 3219481 tacaagcgaa tgtaactata aatgataata attataagaa attcataatt ttatattgac 3219541 taagagaaat aatataggca ttatagtaca tatgtttcgt acattttatt acataggagg 3219601 aaatataatg gcaggaaaac tagtaccctg taaagcttgc ggtcaagaaa ttgcaaaggg 3219661 tgtaaaaaaa tgtcctaact gcggtaagga tcaacgtaac ttttttatgc gacataaaat 3219721 cattacgttt attctcgcag ttgttgtcat cattattatc ggtaatatga ttggcggcgg 3219781 aggcggctca gaagccactt ccaaaacatc aagcagcagc aaagcagaaa ctgaaaaaac 3219841 atacaatatc ggtgataccg taaaaactga aaaaactgaa gtgacggtta cgaaggtaga 3219901 ggacagagat actgtcggta ctcaatatgt tgaaaagaaa gcatctgagg gaggtacaat 3219961 tgtagctgtt caatatacaa ttaaaaacgt atctaaaaag ccgattagct ctttttcaat 3220021 tccaactgtt aaattagttg atgctgatgg tacttcttat gattctgata ttgatgcttc 3220081 tgtaaactat gcaactgaga caaaagttga taactctaaa attttgagtg atctaaatcc 3220141 taatattaaa gtaacaggtg taaaagcatt tgaagttgac aaggaagctt atgcaaaagg 3220201 cacttggaaa ctaaaattca gtaatgatgt tattgtgaaa atcaaataac agctaacaag 3220261 ggtgcctgtt taggcaccct tgttctttaa aaaaggcctt ctcaattgag aaggcctcca 3220321 ttcttattcc gcactcttat acccattcac attagaagac tgccatctcc aggaatcagc 3220381 acacatttcc tcaaggccgc gtttcgcttc ccagcctagt tctcgcttgg ctttcgcagg 3220441 atctgcaaag catgtggcga tgtctcccgg acggcggtcc gcaaaacggt atggaacctc 3220501 tttccctgac actttttcaa aggctttgac catttccagc acgctgtagc ctgtgcctgt 3220561 tccaaggttg tatgcatcgg ctcctgtaga gttcaatact ttttccagcg ccttgacgtg 3220621 gccttctgcg agatcaacga cgtgaatata atcgcgtacg cctgtcccgt cttttgtcgg 3220681 atagtcattt ccgaatacgc ttaattgctc gagcttcccg actgctacct gtgccacata 3220741 cggcataagg ttatttggga ttccgttcgg gtcttcaccg atccgtccgc ttggatgcgc 3220801 gccgaacggg ttaaagtaac gaagcagcgc aacgctccac tcattgtcgg ctgtatgcaa 3220861 atcacgcaat atttgttcaa gcatgagctt cgtctgccca taaggatttg tcgcgcctaa 3220921 tggaaagtct tccgtaatcg gcgatgtttc cggaacgccg tatactgtcg cagatgaact 3220981 gaatacgatt ttcttgacgc cgtatttctc catggcctcg cataaaataa acgttcctgt 3221041 caaattgtta tgataatatt tgaggggaat cgccacagat tcgccgactg cttttaaccc 3221101 tgcaaaatga atcacagctt cgatttcatt ttcagcaaaa acggaatcta ccgcttcccg 3221161 gtccaataaa tccgcttcgt agaacgttaa atcttttcct gtaatctcct tgacacggtt 3221221 cagcgcttca gctgaactgt tggacagatt atcaagaaca acaatctcgt agccgctgtt 3221281 caatagttca acacatgtgt ggctgccaat gtaaccggca ccgccagtaa caagtattgc 3221341 catgatgtaa accctcctaa aaaatgacct gttttcatta tatagtgttt agaaccggtc 3221401 cacatccatt tttaagaagt ttaatcgttt attaatagtt ttttcatatt ttttagctta 3221461 aacccttgcc agcaattcga tagaggtttc agcaagaatg tgctctttca tttcttgata 3221521 gagctcattc aagtaaaagc ccggctgaag attcagctca gcatctaaag catagaccgt 3221581 caatgtatac gcatgatcct tgtcaggcgg tgtcggcccg caatactggt gaatcacctt 3221641 tggatcgttg cttcccgcaa gcggtgaagc aaagctgttt tgcccttgta tcatcaagtc 3221701 ctgtctttcc tcactcgcat gttcaggaag ctctccgatg taagccggaa tattagccgc 3221761 tgtccagtga atccagctga atccgcatac gggaatggcg tcatgatcga tgaaagtaag 3221821 tgcgagcgtc tttgctccgg acgggatgtc atcaaaatga attggaaagg atacaaatgg 3221881 gtttccttct ctcttatatt tttcatccgc gtattttgaa tacttgtcat gtaaatatgg 3221941 atttgcttct acgtatatgt tcatatgaat ccctctctct attttctcgt tctataggta 3222001 tactaaacga atcgatgtat aatcagtgat aaacaaatac gcatgtaaac gtaacaattt 3222061 gttatggata acttgcagtg aaggagatat ttcatggatt taaaatggct gcaaaccttt 3222121 attgccgcag cggaatcaga gagcttcagg gaggcggctg agcatctgta tctcacacag 3222181 cctgccgttt ctcagcatat gaggaaattg gaagatgaac tggacatgag gttgtttttg 3222241 catagcggaa gacgagtcgt actgactgac gaaggcaggc tctttttgcc ttatgccaaa 3222301 gaaatgatcc atgtttacca agctggaaag cagaaagtca gtcaatggaa acaggggtac 3222361 agccgatcac tcacgctggc cgtacacccc tacattgcgt cctatatctt gcctcgcttt 3222421 ctgccagcct atatccaaaa acatccgcat gtcgagcttt caactcatgt ggctggatct 3222481 gacgctatta aacaagcggt ggaacacaat gaagctgata ttggtttgtc gcggaaagac 3222541 ccgaacacca acactcttta ttatcagcat atatgcgaag gtacgctttg tctggcggct 3222601 cctttccaag aaagcagacc ggatgctgca tccgtcttaa cccgctatcg gctgctaacg 3222661 catgatcatc cgtcatatgg ggatgccttt ttagataaca tccgatcaca ttacccgtat 3222721 cttcaaatga tggctgtcgg gcagacggat acggctgtcc acatgatgaa agcgggaatg 3222781 ggggcatctt tcctccctac ctacattatc aaacaggaag aagccgaaaa aaagctgatg 3222841 gctgtcagca cgcctgcaca tctagaattg cctgcgtccc aaacgtttat gatgtggaaa 3222901 agaaacagcg aagacattca gcattttcac gccatgttac atgactttat gcagcgcgaa 3222961 caagtataga gctgaaaaat caatctgccg gttgacgttt ttctttccta ttttcgctat 3223021 gcttaatgca gaaaggattt gatgacatgg cgatgagccc ttatattttt attgtattga 3223081 ttcttattat tttatcgatg tatcgagaaa gaacggtaaa gcccgggaag ttgctgatca 3223141 ttccactgtt gctcttatgg ggcgtatctg catcgtttca gccggcgtat tttcattccg 3223201 tattacatgt ggcgatcagc ggcattttat tactgatcgg gctggcctgc gggtttggca 3223261 ttgggaagat ggtaaatgta cggattcacc cggaaaccgg aaaggtcact tcacgcggct 3223321 cacttgggag tgttatcctc attctagtga tactttcttt gcgcatggcc gcgagaacat 3223381 ggctgcctga gagcaacgag atgtttattg ccattattca ttctatgttc ttcgttcccc 3223441 tcggcaccat cacagcccgc aacatcatgc tttacaaagc atacagacga ctgaccgctg 3223501 gcaaagtatc cattcaataa ccgaaagaag gaccagcatg aacggacaaa ctccggctcg 3223561 gcactactac aagaagcttg tgccgagcct tattctcatt ttgaattgca tacaattttt 3223621 atctcatcca actaaggctg atcccatttt gttagcattt gtatttgcgg tatacttagc 3223681 attcatttgg atcattccct atgtggcatc cactgctgtt agtttgagca tattcatcgg 3223741 actctggctc ctgaccgatt tcttttgggc tgtttccggc caagagcagg gtgccgccta 3223801 ttttttgatt gtatttttaa tgatatatgc cgcctttaga ctcccttcac ggctatcctt 3223861 gatcttcaca gcatgtttaa ttggaggcaa catattactc ctatcctcac aagggggaag 3223921 cttgaatacc atcatcagca acatctcgat catgctcggt ctgtacgtcc tcttctcctc 3223981 catgcgtttc agacgagaag cgagaaggga ggctgaacgg aatcatgctg aattggcaaa 3224041 aatgcatgtg cagctggagc atgctcataa agaactccag aaagcgcatg cagagctgca 3224101 ggaggcttct gttctttcat taaggtacgc ggtccttgag gaacgtacaa gaattgcccg 3224161 cgacattcat gacagcatcg gtcacgagct gacttctgtg attgttcagc ttcaatccct 3224221 tccctatatc cttaaaagca gcaaggagga ttcagaaaaa gtcattcaaa atgtactgag 3224281 tgtcgccagg gagtgtcttc aagaagtgcg gtctgttgtt caccaaatgg gccgtagtga 3224341 atcgatggtg gggcttaccg ctttgcgggg gctcattcat caagtggagg aacggagcgg 3224401 cttgcacgtt tctttagata ctgccggact gtcagaagag tcttggcctc caaacgtgag 3224461 cgaaacgatc taccgcatct tgcaggaagc gctgaccaat atcattcgtc acgctgacgc 3224521 ttctcatgcg gcggccgtca tttctaatga caagtcccat ctctatgtca caatcaccga 3224581 cgacggacaa ttcaccggca gccttactta tggatttggc ctgacaggaa tgaaagagcg 3224641 cgcagaaaaa gcaggcggtt cccttacttt cagtgccgta cagccgagcg gcctgaaaat 3224701 tgagctgtca ttgccgctca tgacaacgaa taaggagcaa aaagatgaac aaagataaaa 3224761 tacgcgtagc gcttgccgat gatcagccgc ttgtgcgtga aggcttccgc tacgtcatca 3224821 acgcacagac ggatatgacg gtttctggcg aggccggcga cggtcacgat attatagcac 3224881 tcgcaaaaca aacaaaaccc gatgtcatcc tcatggatgt ccagatgccg cgttgctcag 3224941 gcatcgaagc ggcgaaagac attatgtccg cacttccaaa tacaaagata gtcattttaa 3225001 ccacctttga cacggaagaa tacgtatttg aaggcatccg tgcgggcgca gtcggctatc 3225061 tgctgaagga tacacttcct gaggagttga tagatgcgat tcgcgctgcg gccagaggcg 3225121 aggcgatttt ccgtacagtc acagctgcta aaatcatcag tgagacattt cgggcgaaac 3225181 agcaaactca tgccgaagaa ctggcagagc cgttcaccaa aagagagctt gaggttcttc 3225241 agcaaatggc ctacggactg agaaatgagg atattgctga aaagcttttc gtcagtgaaa 3225301 gcactgtgaa aacccacgtg caccgcatcc tgcaaaaatg caatgcccaa gaccggacac 3225361 aggcagtcgt ttttgccatt cgaaacggta ttgtgcaata gaaatctctc atcccgccat 3225421 gctaaaataa gacaaaggag atgattggaa atgaaagaag aaatcattga acggtttact 3225481 acatatgtaa aagtcgatac acagtccgat gaatccgttg acacttgtcc ttccacaccc 3225541 ggccaattga cattaggaaa catgctagtt gatgaattga agtccatcgg catgcaggat 3225601 gcagccattg atgaaaacgg ctatgtcatg gcaactcttc cctccaatac tgaaaaagac 3225661 gtgccgacaa tcggctttct cgctcacgtc gacaccgcta cagactttac cggcaaaaat 3225721 gtgaatccgc aaatcatcga aagctatgat ggaaaagaca tcgttcttaa cgaacagctg 3225781 caggtcaccc tgtcacctga tcaattccct gagctgtccg gctataaggg ccatacactc 3225841 atcaccacag acggcaccac ccttctcggc gcagacaata aggccggtat cgctgaaatc 3225901 atgacagcca tggattacct catcaaacac cctgaaatca agcacggcac aatcagagtc 3225961 gcctttacgc ctgatgaaga aatcggaaga gggccgcaca aatttgatgt gaaacggttc 3226021 aatgcatcct ttgcctacac ggttgacggc gggccgctcg gcgagcttga atatgaaagc 3226081 ttcaatgccg ctgccgcaaa aattacgatt aaaggcaaca acgtacatcc cggaacagct 3226141 aaaggaaaaa tgatcaactc tgcgaaaatc gcgatgaagc tgaacagcct gctgccggca 3226201 gacgaagcgc ctgaatatac ggaaggttat gaaggcttct accacctgct gtcgattcaa 3226261 ggagacgtag aggaaacaaa gctccactac attatcagag actttgacaa agagaatttc 3226321 caaaacagaa aagaaacaat gaagcgtgcc gttgaagaac ttcaaaacga atacgggcaa 3226381 gaccggattc tgctggatat gaacgaccaa tactacaaca tgagagagaa aattgaacct 3226441 gtcatcgaaa tcgtcaacat tgccaagcaa gcgatggaaa acctcggcat cgaaccgaag 3226501 atttccccca tccgcggcgg aaccgacgga tcacagctgt cctacatggg gcttccgacg 3226561 ccaaacatct ttacaggcgg ggaaaacttc cacggcaaat ttgaatacat ctcagttgac 3226621 aacatggtca aagccgtaaa tgtcatcgtt gagattgcaa agcagtttga agcgcaagca 3226681 taacgccaaa agccagtcca aaaaaggact ggcttttttg tgtgaaaatg aaacatttta 3226741 aacacgtcct ccgtaaaaca agtatcaaca aatgaggagg aaaaacaatg acaaaacatg 3226801 caatcgctgc caagagtctc ttgaaaaaat ggatcatttc caggccgctt aacatgaaaa 3226861 agaaatccag cccatttcaa aaaatcagaa aaatgttcaa acgcttcttc aaataaaaca 3226921 tcaaatcccc taaatacaat ccgtattcac ccgtaccgcc caaatgctcc gtaatttggg 3226981 ttttttgtgt tcaattccgc aaaatagggt ataaaccaaa caagcaagaa aacagcaccc 3227041 aaaaacaggt aattcgaatt acgtaaactt aggttaaaag ttatataaag gaatttattt 3227101 tatcgtcgat agtaactata gaaccaatca tcaacaagag caaacagcgt aattcaagac 3227161 tattttcagg tcatcaggta atactgtttt agagggacag tttcttgtta tttattgatt 3227221 tagaattttt tgaatacttt ttggcatttt atccgtacaa tagagagtac caaaactttt 3227281 tttgggaggt atgtaatatg atcctattta ttatcatcgc attatgcggc tatcttcttt 3227341 tttctttcag caaggacaat cgccgcaaac cgcaaaagac aagccctctg ccagcagccg 3227401 cacctcatca caacaaccta atcgaccttg acgccatccg ccaaaaacgc cggatgcatc 3227461 tttcctaatt ctatatttca aacgaaaagg ctgctgaatc acgcagcctt ttaaaattgt 3227521 tttgatttag agcctgaaac cttttcgcca cctatccgta atttcataca aggcaaaccc 3227581 aaaggagact tcagcaatga tcgagttatt tatgaaacaa aaaatgttct catttaaaga 3227641 tgcatttcac atttatgacc gggatgaaca agaaacattc aaggtggagg ggcgtttttt 3227701 ctcgttagga gactcattac aaatgacaga ctcatctggg aaaacgctcg tttccataga 3227761 acaaaaacta atgtctttat tgccgcgcta tgagatttca attggcggga aaacagtttg 3227821 tgaggtaacg aagaaagtaa cgttttccaa accgaaattt gtgatttccg ggcttaactg 3227881 ggaaatagat ggtgatttat ggagggatga attccaactg acggacgggg aaaatgtccg 3227941 gatgtcagtg agcaaaaagt ggctcagttg gggtgattcc tatcacttgc agattgcata 3228001 cgaggaagat gttctgattt gcactgccat cgctatcgtg cttgatatgg ttttatataa 3228061 cgatgaagat gaaagtattt tctaaaaagc attgacaatt gatccaaaag taataatatt 3228121 aagataattg aaatctgaat atgaagttgt accttatcaa gagaggtgga gggactggcc 3228181 ctatgatacc cggcaaccgc tgtttcaaac agaatggtgc taaatcctta agaacattgc 3228241 gttcttgcag atgaggcgga gatttgatcg ttcaagctct tccttacaca aaggaagagc 3228301 tttttacatg cttaatattt cagaaaagag gcgaataaca tggctcaaca aacgaatgtt 3228361 gcaggacaaa aaacagaaaa acaacgcaaa gcacctttcc gcgccgatca tgtcggcagc 3228421 ttgcttcgtt ccgttccggt aaaggaagcc cggcaaaaaa aagcggctgg tgagatgaca 3228481 gcggaacagc ttcgtgatat cgaaaatcaa gagatcaccc gcatcgtgga aaaacaaaaa 3228541 gaaatcggtc tcgatgtggt aacagacggg gaattccggc gttcctggtg gcattatgac 3228601 ttcctggaag ggcttgacgg tgtggaaccg ttcatcccgg ctgaggggat tcagttccat 3228661 aacacaaaaa cgaaagcgcg cagcatcaaa gtgacgggaa aactcgattt tacgagccac 3228721 ccagcgctcg gtgattatca atttttacat gagattgccg gtaacgcgac gccaaaattg 3228781 accattccca gtccaaatat gctgtttttt ggcgaaaagg cggataaagg gatttatgac 3228841 gatcaagagg aatactttca tgatatggcc caagcgtaca aaaaagcaat caaagccttc 3228901 tatgatgctg gctgccgtta tctccagctt gatgatacgt catggtctct cttctttgag 3228961 gacaaaggca gagaggttgt ccgggcgctc ggcggtgatc cagaaacatt gccagccata 3229021 tttgccaaaa caattaacga tgccgtcgca gaccggcctg acgatttaac gatcacaatg 3229081 cacatttgcc gcggcaactt ccgctcaacc tgggcggcat caggagggta cgacgctgta 3229141 gcggaaacga ttttggacgg cttaaacctt gacggccttt tcttggaata cgatgatgac 3229201 cgctccggaa actttgatcc gctccgtttt gtgaagcgca aggatctgca aattgtgctc 3229261 ggcttgatca catcgaaata cggcgagctt gaaaatcctg aggatgtgaa acgccgtatc 3229321 aatgaagccg cgcgttttgt cagcttggac cagctatgcc tgagcccgca gtgcggtttc 3229381 gcctctacag aagaaggcaa ccttctgaca gaggagcagc aatgggcaaa gctgcgccat 3229441 gtcatcgaca ttgccaacga tgtgtggaga taatctatca ttgacagaaa tagaaaatgt 3229501 gtgaataata gatactatca gaaaatttaa taaaaaggtt ttccttatca agagaggtgg 3229561 agggactggc cctgcgatac ccggcaaccg ctgtttaaca gaatggtgct aaatccttta 3229621 gagcaatgat tgctcttgaa gataaggttg agattgtcac gcaagctctt ccttatccaa 3229681 aggaagagct tttttatatt tgaatggaaa gaaggaatgg acaacatgtc acaacaaaca 3229741 acacccgcag aacaaaaatc acttcaaaga aaaaaaccgc cgtttcgcgc ggatcaagtc 3229801 ggaagcctgc taagatctga gcccgtcaaa aaagcgcggc tgcaaaaagc ggccggcgaa 3229861 atgaccgctg agcagcttcg ccaaattgaa aacgacgaaa tcatccgcat tgtggaaaaa 3229921 cagaaggaaa ccggcctgaa cgtcgtgaca gacggtgaat tccgcagagc atggtggcac 3229981 tttgatttcc tggaaaactt agatggcgtt gagccgttta ctcctgagca aggcattcaa 3230041 ttccataacg tacagacaaa agcacgcggc attaaagtca caggcgatat cgacttttca 3230101 actcacccaa tgcttgaaga ttactcattt ctccatagca ttgccggtga cgcgacgcca 3230161 aagatgacga ttccaagtcc gaatatgctg tttttccgcg gaaaactgga aaaggatgaa 3230221 tacaaaaacg attatcaact tttccagcac gatgtatcca aagcatataa aaaagcgatt 3230281 caagcgtttt atgacagagg ctgccgctac ctccagcttg atgatacagc gtgggccgtt 3230341 ttcttatcag aaaaaggctt aaaacaaatc gaagcgttcg gaacaacgcc tgacgagctt 3230401 cgccagctgt ttgcgaaatc cattaacgac gcgattgcag accgcccgga tgacttgacg 3230461 gtaaccatgc atatttgccg cggcaacttc cagtccactt ggacagcgga aggcggctat 3230521 gacgcagcag ccgaaaccat ttttgacggc ttgaatcttg acggactttt cttagagtat 3230581 gatgattcac gctcaggcgg atttgagccg ctccgttacg taaaacggtc tgatcttcag 3230641 cttgttcttg gcttagtgac atctaaattc ggtgagcttg aaaatccgga tgacgtgaaa 3230701 cgccgtatcg aagaagcgtc ccgttatgta agcttagacc agctttgcct cagccctcaa 3230761 tgcggattcg cttcaactga ggaaggcaac aagctgactg aagaacagca atgggcgaag 3230821 ctccgccatg tggttgagat cgctaatgat gtttggaaat aagcaaagaa aaaaacacac 3230881 ttgattccct agcggagcaa gtgtgttttt tatgtcattg tgcggtgtag cccccatcaa 3230941 ggacgacagc ctgcccagtg acgcccttcg ccttctcgct tgccaaaaac acggcataat 3231001 ccgcaatttc cttgacggaa agcagtcgct tttgcggcac aagcggaaaa atgacttgtt 3231061 caagtacaga gtcgtaaggg acatttctag ttttcgatag atcgctaagc tgattgcgta 3231121 caagctgggt atcgacataa cccggacaga gcgcattgac tgttatgccg tggggcgcgc 3231181 cttccagcgc ccctactttt gtgagtccaa tgacgccgtg cttggcgcta ttataagcgg 3231241 atttccctgc aaagcccact aatccattaa cagacgcaat attaatgatt ctgccaaact 3231301 gctgtttttt catgatcgga aaaacatgct tcattgcaat aaagggagcc gtcagcatga 3231361 ccttgatcag ctgttcaaag gtgtctgtcg gaaactcttc aatcggagcg acgtgctgaa 3231421 taccggcatt gttcaccaga atatccaagc ggccgtattg tttttggatg acgttcaccg 3231481 tatcagcaac ttgcgcttcc tttgtcacat catacggaat ggccgccgcg tcaaagcctt 3231541 cttctgcaag cttggaggct gctttttcac atgcttccgg acggaggtct gaaacgatga 3231601 cgctggcacc ttcccgggcg aattctcttg cgatttcgaa tccgattccg ccggcagccc 3231661 ctgtcaccaa agcgacttgt tttctcatgt caaacacctt cccattaaga attgagtaca 3231721 gactggctta cagcgaaatc agcttctgtt ttttcataaa cctcttcaat tgtgacacca 3231781 tcctgaagct ccgtcagtgt catgcggccg ttcacaaaat caaatacagc caaatccgta 3231841 atcagcctgt gtacgacttt ctggcctgtc agcggaaggg agcatgtttt tttcaccttt 3231901 gattcaccat gcttattgac gtgctccatg atgacaacga ttcgtttcgc cccgttgacg 3231961 agatccatgg cgccgcccat cccttttacc attttgcccg ggatcatcca attggccaaa 3232021 tccccctgct ccgaaacctc cattccgccg agaatagcta aatcgatatg cccgcctctt 3232081 atcatcgcga atgactcagc gctgtcaaaa taagaggcgc ctgtcacttc agtgatcgtt 3232141 tcctttcccg cattgatcaa atccgcgtct tccgttcctt ccagaggata ggggccaatt 3232201 ccgagcaagc cgttttccga ctgaagcatg acgtgaacgc catcgggtat ctcatttgcg 3232261 acaagcgtcg gcattccaat cccgagattc acattcatgc cgtccttgat ttcttgtaca 3232321 gcccgtttga ccattcgttt tctcgcttcc ttcacttggc ctcacccttt cccgatgctt 3232381 gctgaactgt tcgtttttca atccgttttt cttggctcgc gccaagcacg acatgctgta 3232441 cgtaaattcc cggcgtatgg atgtgatctg gatcgagctc tcctgcttcc acgatttctt 3232501 ccgcctcggc aatcgtgatc ttgcctgcca tggcggcaat gggattgaaa tttctcgccg 3232561 ttttcctaaa aatcaaattg cccatggtgt ccgctttcca cgctttgacg atcgccacat 3232621 cgccggtaat gcctcgctcc agcacataag tccggccgcc gaatgtttta tgttcttttc 3232681 cctcggctat ggaggtgccg acgcctgtcg ccgtataaaa tcccggtatg cctgcaccgc 3232741 ctgcacgaat tctctcagcg agcgttcctt ggggaacaag ctctacctca agctctccgc 3232801 ttaaaaactg ccgctcaaaa attttatttt caccgacata ggaagcgatc attttcttga 3232861 tttgcttgtt agccagaagc aaaccaagcc cccagtcatc gactccgcag ttattgctga 3232921 caacggttaa atcctttact ccctgatctc ttatagacaa aatgagctgt tcagggatgc 3232981 cgcacagccc aaaccctccc gcgatcagcg tatccccatc atgaatcagt ttcgcagctt 3233041 ccttgcttga tgacagcact tttcccatat tgatgcccct ttcgttttct tctacactag 3233101 accagtcagg ctgtaaatcg cgatcacagc aaatacggca gccgttttaa tgagcgtgat 3233161 cgcaaaaata tcgcgatagg attgccggtg ggtcaaaccc gtcacggcca gaagcgtgat 3233221 aacggcgcca ttatgcggca gtgtatccat cccgcctgat gccattgaaa tgacccgatg 3233281 catcacctct ggcggaatat tgtaagcctg aatcgcctgt aagtattgtt ctgacatcgc 3233341 gcttaacgca atgcccattc ctcccgaagc cgagccggtg attcccgcca gcgcagttgt 3233401 cgtaacggcg ccatttacaa gcggatcggt aaaagtatgt gaaattccgc tgctcagctt 3233461 atgaaacccc ggcagcgcgg cgataatgcc gccgaacccg tactcagcac ccgtattcat 3233521 agatgccagc aaggcgccgc caattccttc attcagccct tccttcaatt gggcaaacac 3233581 acttctccaa tcaaataata tcgttgtgat gatgccaatc actaaagcaa tctccaccga 3233641 ccaaatagca gccgctgaag aaatatcaag cctgccgaac tcctttaatc ctatggaaga 3233701 aaaatcaaat ccattcggat accactttgg caggtaaatg gtgaaatatt tattcactgc 3233761 accgacgaga ataagcggga caaaggcaag cgcgtgccga atcgggcttt tgtccggttc 3233821 agccgcggac tcaatcgatt caggagcagg agcattctgc gaatcaaaac cgccatagcc 3233881 ttcgccagat gcctgcgctt tcttccgcct tgattccaaa tagagcatcc cagctgccag 3233941 cacaatcact gcgcccatca aacccagcca aggggcggca taaatgtctg ttttgaaaaa 3234001 cgacgtcggg atgacatttt ggatttgcgg cgttcccgga agtgcgtcca tcgtaaacgt 3234061 aaaagctcct aaagcaatcg tacccgggat gaggcgtttt ggtatgtttg cttcttggaa 3234121 catgtttttc gcaaaaggat atacagcaaa tacgacaaca aacaggctga caccgctgta 3234181 cgtcaagaca gcacccatca gcacaatggc aagtatcgct ctttttgccc cgacaagccg 3234241 gacaattgtt ttcgcgattg atgccgcaag cccggccatt tcaacgacct ttccaaaaat 3234301 agcaccgagc aaaaacactg ggaaatacag cttaataaaa cccgccatct tctccataaa 3234361 aattgatgaa aaaaaaggaa gcacatggct tggatctgtc agcagcaccg cgaataacgc 3234421 gcaaatcggc gcaaacaata tgacagaaaa tccccgatac gccgtaaaca tcagcaaacc 3234481 taacgccaat agaatgatga tcagttccac acacacatcc cccgtttccg cgaactagaa 3234541 agcgtttaca aaaacctgtc cgcatcggct gtttccgtcc cctttccata tgtacgagaa 3234601 gcgtgggcca actattccga ttaaaaaagg aaagctcctt ttttcggagc tttcctctac 3234661 cattcatttc attcctatta ggatatcaac atcaaccgta atatcggctg atttcatctc 3234721 tttcagcagg ctgactcgat ctttcggcgc cgaccaggca agcggcgtca tcttgagaag 3234781 ccagtggatc gcctgctggt caagcgtttt aacatagcgc agcctgacag gacggctgtg 3234841 tgctgcattt gctgtaaaac gctcaactgc tgccgtattg gaatacgtgc gccttggtga 3234901 atcagtatat aaaaattgcc ttaattctat taaatagtcg cttcgcggca ctacttttat 3234961 gagcatgcca tcattcttca gcagtctatg aaactctgca taattggacg gcgaaaaaat 3235021 agacagaaca acatcaaatt ggcgatcatg aaaaggagca cgcgccacat cggcaaccgc 3235081 ccacatcaga tctttgaatg ccttagaagc ttttaagatc ccgtccttcg aaagatctat 3235141 gccggttcct atcgctgctt tccctgcata atcaaacccg caaagcgcat tcaaatgaga 3235201 accctcaccg caaccgctgt ccaagatggt gaatgcctca tgaccagatt tgggatgact 3235261 gatgagctct gcaatcgcat catggagcgg gtcaaaaaaa ccacattctc caatcagcct 3235321 gctcctcgct tcaaaaagct cggcaccgta actggttttg accggcttcg tcagaaagtt 3235381 cacgtagccg tgccgagata gatcaaatgt atgtcctcgt tctgtacaaa tcaagctttt 3235441 ccctgatgcc gcatccatag aagaatcgca gagcgggcat cgaaacatgc tgaaatcaac 3235501 tgttcgcttc atgataaaaa acaccccatt cattcatttt tagataaatg aaaaaggcat 3235561 agacaaataa acctaggcct atctcaaaaa ttggccaggt ctggcagttt gtctacacct 3235621 gtcattatct ataacgaatg aattggataa tcatgaaaaa aactcccttt ctgctgtatg 3235681 ggtttccccg tttccatcat acaacaaata tccaggagct ggaaccttat agtgaagaaa 3235741 aatcagtact gacatgctgg tatcccgcca acatcatatc agcatagcaa tccagcatgt 3235801 ttttccttta ttttctcatt ttagaatata aattttatta ttgtgaaaat agttaaaaag 3235861 gttgattttc aaaaagtgaa aggataaaat actgctatca tcttagaaaa agacattctt 3235921 gtatatgatc agtaatatgg tctgattgtt tctacctagt aaccgtaaaa aactagacta 3235981 caagaaagtt tgaataaatt tgaacgagtt gaaaaggaca agttcttttc tgtttgctct 3236041 tatttttcac actttctgca cttccagaat ttgtgaagga taagagcttt ttttgtttcc 3236101 ataataaccc tcataggagt tgctatcatg tactttttac taaaccttgt cggtctcatt 3236161 gtgattatgg cagttgtatt cctatgttct ccgcagaaaa agaaaatcaa gtggcgcccg 3236221 atcattacgt taattgttct ggaattgctg attacttggt ttatgctggg aacaaaagtc 3236281 ggaagctggg ccatcggtaa aatcggtgat ttcttcactt ggctgattgc ttgcgccagt 3236341 gacggtatcg cgtttgcctt tccgtcagtg atggcgaatg aaacagtaga ctttttcttt 3236401 agtgcgcttc ttccaattat ctttatcgtc acattctttg atattttaac gtatttcggc 3236461 attttgcctt ggctgattga taaaatcgga tgggtgattt caaaggcttc ccgcttgccg 3236521 aaattagaaa gctttttctc tattcaaatg atgttccttg gaaataccga agcacttgcg 3236581 gtcatccgcc agcagcttac ggttttaagc aacaaccgcc tgctcacatt cggtttaatg 3236641 agcatgagca gcatcagcgg ctccattatc ggatcttatc tttcaatggt gcctgcgaca 3236701 tacgtgttta cagccattcc tttgaactgc ttaaacgcgc tgattatcgc aaacctgctg 3236761 aatcctgttc acgtgccgga ggatgaagat atcatctata caccgcctaa agaagagaag 3236821 aaagactttt tctctacgat ttctaacagt atgcttgtcg gcatgaacat ggttatcgtt 3236881 attttggcaa tggtgatcgg atatgtcgca ttaacgtcag cagttaatgg cattcttggc 3236941 gttttcgtac atggcctgac catccagaca atttttgctt atctgttcag tccgttcgca 3237001 ttcctgcttg gactgccagt gcacgatgcg atgtatgttg ctcagctgat gggcatgaaa 3237061 ttagcaacga acgagtttgt tgcgatgctt gacttgaaaa acaatctcaa atcccttccg 3237121 cctcacaccg ttgcggtggc gacgacattc ctgacgtcct ttgcaaactt cagtactgtc 3237181 ggcatgattt acggcacgta caattcgatc cttgacggag aaaagtcaac ggtcatcggg 3237241 agaaacgtgt ggaaactgct cgtcagcgga attgcggtat ctttattaag tgctgcgatt 3237301 gtcggcctgt ttgtgtggta gaaacattga gccatatccc ttttcggata tggctctttt 3237361 cattattgat aaatagaggc tggcacctgc acatcccgga ttcccgctgc ataaggcccc 3237421 aagtcatact ggccgaagac gatggcgatc ccgtttgccg taaagtaaaa cattgtgtct 3237481 ctgtttaggg ttatatcctc tttctttaca tcagagaaaa acagcacatc gtgttttttg 3237541 atatagctat ataggtaatc tctcgttttg ctgacttttg ttttggtgtt cagaatctga 3237601 tccagcgtca cccgcttttg tgctttcaag tcatagttga aggactggac agacgttaga 3237661 ccgtgggcgc cccctgaata gatataattg agtgtttgaa tgctgagctt gcctgccgca 3237721 ttgtatttga cgctgaagga tgtttgatat tcccgtttta aagccctgct gttcgcctgc 3237781 ttttttgttt ttcaggtatt cctgatacga ttgttcatgt aggctttcag ctcttgattg 3237841 attttctttt caaacgcggc attcccgacg tgatgcactt gtggatacgt taactccttg 3237901 atctttttgt acgtatgggt gctgacagtc ggtgttttcg cttgaactgc ttttaaagat 3237961 ggggccgcat atgcaaatac agaaaaaagc aagactgcaa tgcccgcggc tttcagcatg 3238021 ttattccatt tcatacaatc tactcctttg atgtcgttgt ttatcattcc cttatttaag 3238081 caatacacac ttttatagac tgattaaatc gaaagaagtt tctaggtcta acagcatgat 3238141 ttttccaata aaaaaagaga cacaggatgt ctcttttttt actgtttgcg cccagaaatc 3238201 gcttcatgaa gggcttgtgc caaatctgta tttccgaaca tctctaatac cgcaatgaca 3238261 gtctggtccg gaatgtgctc tgcttcgtgt tttggcacga ccagatcgtc catggttttt 3238321 ttcaagcttt cattcagctt ttgctgcgga tacgctttgg cgtacagctc catcggatca 3238381 agatcatggt tcacgcacca ctgggcaaac accaaaatca tcatattttc atcgcgttcg 3238441 taagcttcag tgagctgttt ttcgttcatt tgtcatgctc cttatgaaaa gtatcttcct 3238501 taaagataca ggagccgatc aaattcgtct atcccaatgg cgatgagcag caaccgcatc 3238561 gataaatgcc ttgctgaaag cggtgtagtc aggttcatct ttagccgtta cgatgcctag 3238621 cccctctgtt gtcccgacag aggattgaag aaggtcaatt ccttcatttg ccgcaccgat 3238681 cgccttgtag tgattgtaag cttctctgat aaacgccatc gcttgtttgt tgtcttttaa 3238741 ctccagtcct cctgcggcat agacggcatc atacagaaca gaatcaaccg tcaggaacgt 3238801 gccgctggcc tcaagctgct gtccgctgcc gcttgtcata taccccagat tttgactgat 3238861 gatatccact gtgattcctt cttgctttaa ggcttccagt actgtttgca gctctttttc 3238921 atgaaatccg tttccggcga gtacagcgac ttttcttgtt gacgcggttt tcactgtacg 3238981 ggcttggctt aacgcaggcg aagtaagaat ttctttagat gctttacgct tcgcgggcgc 3239041 cgccacgcct actcctttgg cgatttcttc tgctaaatct gcatcgacat tgctgaagac 3239101 atcaacgacc tgccgctgta cgtctttgct tttgaccttc ccgacctcga agcagaaagc 3239161 agaaatgatg tgctgtttct ccacaggaga catgctgttc cagaaaagct tcgcctgtga 3239221 gtaataatcg ttgaagctgt cgcttcgctg gcggattttt ttgccctcga ctttttcctg 3239281 atagtggacg tagccgcctt cttcagctgt cgcaggcgac ggatcattgt tttgcagtga 3239341 gtttttatga taagcgacag gtcccttatt gatcgtcatc cggtgatagc cgtcgtattg 3239401 gttgttatgg aatggacaga ccggccggtt aatcggaatc tcatggaagt tcgggccgcc 3239461 aagacggatg agctgtgtat ccgtataaga gaaaagccgc ccctgcaata gcgggtcatt 3239521 ggtaaaatcg atgcccggca cgacatttcc cgggtggaat gcgacttgtt ctgtttccgc 3239581 aaacacatta tcctgattgc ggttcagcgt catttttcca atgatcttca ccggcacaag 3239641 ctcttccggc cacagcttag ttgggtcaag aatatcaaaa tcaaacttga attcatcttc 3239701 ctcatcaatc atctgcacgc cgagctcgta ttcaaccttg ccgccgtttt caattgtttc 3239761 ccacaggtca cggcggtgga aatctggatc tttcccggca attttttgcg cttcatccca 3239821 tacgagagaa tgcacgccga gcaccggctt ccagtgaaat ttcacgaaac gtgcctttcc 3239881 ttgttcattg acaaaacgga acgtgtgaac gccgaagcct tccatcattc tgtagctgcg 3239941 cgggatgcct ctgtcagaca tcgtccacat caccatgtgg gcagactcag ggttattggc 3240001 gacaaaatcc caaaatgtat cgtgagcagt cgcagcctga ggcatttcat tgtgtggctc 3240061 aggcttaaac gcgtgaacca aatccggaaa tttgattgcg tcctgaatga aaaacaccgg 3240121 aatgttattt cccacaaggt catagtttcc ttcttcagta taaaattttg tcgcaaagcc 3240181 tctggcatcc cgcaccgtgt ctgcggagcc tttagaaccc gcaaccgtag aaaaacggac 3240241 aaataccggt gtcttcaccg aagggtcctg aagaaatttg gcccgtgtgt attccgtcat 3240301 tggttcgtaa acctgaaaaa agccatgcac gccaaatccg cgcgcatgca caacgcgctc 3240361 cggaatcctc tcatggtcaa agtgcgtcat tttctcccgg aaatgaaaat cctccatcag 3240421 cgtcgggccg cgaaccccgg cttttaacga gtgctcatcc tctgacactc gcaagccttg 3240481 gtttgtcgtc attttcttcc cgctgttatc ggtcctgtac tgctcaagct gctcgtcctt 3240541 tgagtgttca tttacacgtt tgttttggtc atcactcatg tctgctcccc ctttttaaaa 3240601 cgaaacattc tacagcacat ttacccgtgg cgttcttcat ataaactgct aatccgctca 3240661 ttaggatttt tggtctacat ataaatatgc ggtcatacac atttgaaata agccttcttc 3240721 acagaaagaa aggatggaag cgcttaccaa aaaagctgtt gaatagggga ggtcatatca 3240781 tgcttgccat actcggtttt gtgatgatga ttgtctttat gtaccttatt atgtctaacc 3240841 ggctttccgc tcttattgct ttgattgtcg ttcctattgt gtttgccctg atcagcggat 3240901 ttggcaaaga tctcggcgag atgatgattc agggcgttac agacctcgcc cctaccggta 3240961 tcatgctgtt attcgccatc ctgtatttcg gcattatgat tgactcaggc ctgtttgatc 3241021 ctctcattgc caaaatctta tcgtttgtca aaggagatcc gttaaaaatc gccgtaggca 3241081 cagcggttct gaccatgacc atttcgctgg acggagatgg gacaacaacc tatatgatta 3241141 ccattgcagc gatgctgcct ctctacaaac ggctcggcat gaaccgtttg gtgttagcgg 3241201 gaatagcgat gcttggttcg ggggttatga atattatccc gtggggcggg ccgactgcga 3241261 gggttttggc ttccttaaaa ttggacacgt cagaggtctt tacaccgctg attcccgcta 3241321 tgatcgccgg cattctctgg gtgatcgccg ttgcttatat cctcggaaag aaagagcgga 3241381 agcggctcgg cgtcatttcg attgatcacg caccgtcttc cgacccggag gccgcaccgc 3241441 tcaagcgtcc cgctcttcaa tggtttaacc tgctgctgac tgtcgctctg atggccgcac 3241501 tgatcaccag cctgctgccg ctccctgttc tttttatgac tgcgttcgcc gttgccttga 3241561 tggttaacta tccaaatgtc aaagagcagc agaaacgaat ctcggcgcat gcgggtaatg 3241621 cgttaaacgt tgtctcaatg gtgtttgctg cgggcatatt cacaggcatt ctctccggca 3241681 caaaaatggt ggatgccatg gcgcattctc tcgtttcact catccctgat gccatgggcc 3241741 cgcacctgcc gttgatcact gcgatcgtca gcatgccctt cacctttttc atgtcgaatg 3241801 acgcctttta cttcggtgtc cttcccatca tcgccgaagc cgcttccgct tacggaatag 3241861 acgccgctga aatcgggagg gcctccttgc tggggcagcc tgtgcatctg ctcagcccgc 3241921 ttgtgccttc cacctatcta ttggtaggaa tggcaggcgt cagctttggc gaccatcaaa 3241981 aattcactat taaatgggcc gtgggaacaa cgattgtgat gaccattgcg gcgcttttga 3242041 ttgggattat ttctttctaa atgtatgagc ttgatcgtag cattgagtga gtacgtgatt 3242101 tacagagggg agaagatcaa ataggatatt atgagtgaat agaagattca tgccaacaac 3242161 ttctcattac aatcataaga gcctgctata ttgcagcagg ctctttcaca tttggcatta 3242221 tttttttgta tagcgcaccc agtcataatg agcgtatagc ggatttacac cattgtagga 3242281 gccaagccat tcatcgacac ccgtgccatt ccacaagttc atcatgatct ttccaggtgt 3242341 tgtcggaatt tggtttgttg cagtatgttt taattgcccg tcgacatacc atttaataga 3242401 gtttggctgc caatcgaatg catacgtatg ataggcattg gctgcatcaa acccgagatc 3242461 aacaatcttc tcatggtttc ctgcaccatt tgtataatag ttaaattgaa ccttcgttgt 3242521 gtcttttcct aaaaattcga tatcaatctc atcccaagga gttccatctg ttggacctgt 3242581 gtaagtgaag aacgatgaaa cgatccctgt gtttttagct ggtttcattc tgacttcata 3242641 aagtccatag ccatatgttt gaacagaacg gttttccccg cagtcaaact tgttataagc 3242701 tgggcttgtt agcgctaaac gcatttcacc caatgacgtc attgatacgt tattagcccg 3242761 ccacgtgcag ttgaacatat ttccattcga ataaccatct gctttttgcc aaaaaccgga 3242821 gttatagccg ttaaaagggt caaaaaacga tccacctgtt tgagctgagg cagtagcagt 3242881 gactgcaaac aaactcataa acaatccagt gacaagaagc agcaacactc gtttcagata 3242941 aggcatattg gcattcccct ttcattgaaa gcgttttcta tgttgatctt acatgattct 3243001 tttaaaaggg aacatcggtc aaaataatga taatatcgaa tcttactaac ttgaatcctg 3243061 taactatcat catcttccct ctgaaaaaaa taaaaaccta aattaccatc agcacagaca 3243121 gagatgatcc gcactcattg caatttaggt tttgcctgct ttatcagtaa caatcctacc 3243181 attttcatat gtgaatgtaa gaaaaagtga acacaaggaa acacaaatgt cagcgctctc 3243241 attatgcttg tttaactacc ctttctatgt gaatggttaa atacagcagc tcgtcacttg 3243301 tgagcttgtg ctcatactcc cgctcaatgt aggtttggat tttcttcgtg cattcatacg 3243361 cgcgatgata cttttctttc actgtatcca gcaaaaaatc gtcctggctt tccatgtgag 3243421 tgccgttaaa tagacgctgc gcgaaaaact ttaagtgggt gacgaaccga taatagtgaa 3243481 gcgattcttc gttgaattca atcttaaaat ggtattttac aatactcaaa atctcttgca 3243541 tgacttttgt aatgttgata atattgggca tctcttcatt cagctcggca tttacaatat 3243601 gcagagcaat aaagcctgct tcatcctctg gcagagacac accagtcttg ttttttacca 3243661 taaccaacgc ttctttgccg atcgcaaatt cgtctttgta gagccgtttt gtttcccaca 3243721 gcaaggcgtt tttgatatca agccctttct ggttgcgctg gatggcaaag ttaatatggt 3243781 cggtcagcga cacatagatg ctgtcgttga gctttttgcc gagctgtaat tttgcgtagc 3243841 tgataatctc ttcggatact tccatacact cgatcggtat atcatacaaa agggttttga 3243901 acttttctga tacatccttg ttatcgagcg tgaacacttt ctcaatgcgg gcttcatcga 3243961 catcatcgcc ggactttttc tgaaacgcga gccccctgcc catgacgacc aattctttcc 3244021 cctgttcatt gaccacgctg atcacattat tgttgatcac cttcgcaatt ttcatggcat 3244081 gtccctccaa atctactaag aacagactat atcttgattg tacattcttt ttgtactagg 3244141 tcaatatcat cagggaaaga cggaagctgg tcagtacaat tcactccgta cctgctgccc 3244201 gggctgtttt tgaagcagcg cctccagatg gcgttcaaat gatgccttgt cagctttctg 3244261 ctttttgaca atgctgttca tgattttaat gctttcagca ctgtattgtg tatattgttt 3244321 tttcagctga tccagctgct gtcttgtctt cttcgcgttt ttcggtgtga cttggttgat 3244381 gagtttgatc atactgtctg cggtctcaaa aaaaccggct ctattttctg tcagctgctg 3244441 aatttcgatg cggctcatat cttgattacg cgttttttga agcaaggcaa ccgcctcgct 3244501 gttttgtttt ttgagcgatt tgttctcaag cttaatcgat tcgagattct ccttcgcaat 3244561 gtctgcttct tcttcagtca tgctgattcg cacgaagtat tctggattgc cgattccata 3244621 atcaaatgct tcgctcactt gtatcatgga actgaacaca atggccagct gcctgtcgct 3244681 tgcgagggct tggaaatcct gctttttctt actgctcatc ggtttggctg cggtttgttt 3244741 tactgtcttt tgatcacagt ctgcgaacat ctgagcctca ccttcacttt cgcatgcgct 3244801 catcacaaga actgtgacca gcaggcttat acacaagcct attcgcctca tgctctgtct 3244861 cctctctgct gaatcccttc tggaaaatac cataaaatat agttaaatgg taccagatgc 3244921 acctaacccc agcaataaat caaaagtatg atttgaagcg aaaaaacata aatattttgt 3244981 aaaaattgac gtgcattcca ttcttttcag gcccatttct cgtacaatag aagtatcgtt 3245041 accggagagg ggctctgatg atgaaacgtt ttacgaaaca agaaaacagc tgggtgttat 3245101 atgactgggc aaattcagct tactcaattg tcgtgaccac cgcggtattt ccgttatttt 3245161 ataaatcagc agctgcggaa agcggtgtca gcgccgctca atcgactgcc tatctgggct 3245221 ataccattgc gatttcaacg tttattcttg cgatgctcgg ccctatttta ggcacaatcg 3245281 ccgactatga agggtgcaag aaaaagttct tcggtttctt tgtgtcagcc ggtgtcgcca 3245341 gcaccgcgat gctcgccttt atccctagtg aacattggct gctattgttg ctgttttata 3245401 cggtatcggc tatcggtttt tccggcgcca atgtgtttta tgatgccttt ctcgtggacg 3245461 tcacgcctga gaagcggatg aatctcgtct cggcacgggg ttttggctta ggatacattg 3245521 gaagcacgat tccatttatc atcagtattg ctgtcatcct gctcgcacaa gcagagacta 3245581 ttccagtgtc tgtatcggcc gcaagccagc tgtccttctt cataacggct gcctggtggg 3245641 ggctgttcac catcccaatg attaaacatg tccatcaacg ctattacatc aaaaaagaac 3245701 ctcatattgt catcaacagc tttaagcggc tcggccaaac gatgaaacgg atcaggcaat 3245761 accgggcact tttcctcttc ttgctcgctt atttctttta tatcgacgga gtcggcacga 3245821 ttattacgat gtcgacatcc tatggatcag atttagggat cggctcctca agccttctga 3245881 tcatcctatt tgtcacccag gtagtcgccg cgccgttttc gattatatac ggaaaactgg 3245941 cagaacgctt cacggggaag accatgctgt acgtcgggat cgtcatttat atgatcgtct 3246001 gcgtgtatgc ctattttatg gagacaacgc ttgatttctg gatactggct atgcttgtcg 3246061 ccacctcgca aggcggtatt caagccctaa gccgttccta tttcgccaag cttgtgccaa 3246121 agcgccacgc caatgaattc tttggcttct acaacatttt tggaaaattc gcctcaatta 3246181 tggggccgct gctcattgcc gttaccgccc agctgaccgg taaatcctcg actgcggtgt 3246241 tcagcctgat cattttgttt gtgattggta ttgtgattct tgcctttgtt cccgaggaaa 3246301 ccagcacaga tgtcagccag cagcaaaatg acctgcccct ttaactggga gcaggtcatt 3246361 catcatttat tcgctttatt caccttcagc tgtttccctt tgacggttgt gttcttcatc 3246421 actttgagaa catgagggcc tttaccattt aaaatctcaa cgtatgaggc gttatccatg 3246481 atcgtgatga tgccgatgtc gtcagctgac acaccgtcaa ttttggcaat cgttcctaca 3246541 aaatcaacgg ctctgatttt ctttttcttt ccgccgttaa aatacagctt cataatgtct 3246601 ttattcagct cttcgctttt gtcctttttg ctttccggac ggtcattcag tttagctaga 3246661 aattctggtt tcttccttgc cacttcctct tgagaaggtg cttctatttt ttggatttca 3246721 aatccgatat attcttcaat gtcggctaaa aaccgttttt cgaaggccgt gacaaacgaa 3246781 atggcctttc ctttgttccc tgcgcgtccc gttcggcccg tgcggtggac atagctttct 3246841 ttttcaagcg gcagatcata gttgatgaca agggagatat tttcaatatc aatcccgcgc 3246901 gcggcgacat ccgtcgccac taagtaacgg tactcgccac gtttaaattc attcatgacg 3246961 tcgaatcggt cttcctgaat cattccgccg tgaattttat cgcatggata tcccaagtca 3247021 tccaattcat cggtcagctg attgacgtgc tccttcgttc ggcagaaaat gatgcagctg 3247081 tcgggattct ccgtcatcag cacatctttc agcaatgaaa acttattctc ttctcttact 3247141 tgaatcaccg catgttcaat atttcttgtg gttaggccgg ccgctttgac ctcgatatgc 3247201 tcggggtttt gcatatattg acggctcagc ttctcgatat cctgcggaag cgtcgctgaa 3247261 aacagcatcg tcgtacgctc agtcggcaga tgcttgataa tcgcctccac ctgctcaatg 3247321 aagcccatat tcagcatctc atccgcttca tcaatgacca aataagagag acgatccaac 3247381 ggcagcgtgc ctttttcgat atgatccaga acacgtcccg gcgtgccgac aacaatgtgg 3247441 cttttttgct taagctcagc tttttgttta tcaaaggagg attttccaaa tacggctgtc 3247501 gctttgatcc gtttaaatcg tccgatgttc gtgatatctt cctttacttg caccgcaagc 3247561 tcacgggtcg gtgttaaaat aagcgcctgc ggcttgtttt catcccaatt cgccagctca 3247621 cagagaggaa tcccgaacga agccgttttc ccgcttcctg tctgtgattt gacgacaaga 3247681 tcctttcgtt caagggcagc ggggatcaca ctctgctgca ccttggtcgg ttctgtatat 3247741 cccagtcctt ccaatgctcg taaaatgtca tgactgattt gatagttttt aaaatgactc 3247801 atgtataaac tcctgtctct tgcagatgtt ctcattatac tctaattgac caaggcatat 3247861 gtgttttgtc gaaaaatgat gtattaaaag ccagcgattc cctggcgttt tagctcctga 3247921 acagccaatc gcgccagtgc gtcggccccc gcgcgattcg ggtgcagcgt atctccatcc 3247981 atataaagcc cgagtgttct ttccggaccg atcgatgtaa agtatgccga gctgaggaca 3248041 tttaagtcaa tgagatatgt tttttcctct tcggccaaag ctaaaataga ggccctgtac 3248101 catctgttta cagacgaatg gatgccttca gaagtaaaat cggttgcccg gccctgaggc 3248161 gttgatagga tgacgtccgc tcctttcgct tttacctgac gaatcatatc acgcatcacc 3248221 tctttaaact ccgcttcaga ttctttatgc ttcggatttg tgtcattaat gccaagctgc 3248281 aacataaaat aatctccggg tttaatatac ttcagaatcg cctcaagctg tccatcattt 3248341 ctgaaccctc tcgcgatctg cccgccagac gccatgtttc tcacttgaaa ggtgtgttta 3248401 tcgatatagt gaggcagcat ctgcccccag cccgcctgct tgctgctgtt gagcggataa 3248461 taattgcaca ccgtcgagtc gccgccgaca taaatggttc gattcgttac cggctgatca 3248521 gacaatttct ttattttcaa ggcgctgagc gtaaaagcgg tgcctgcctt tccctctgtc 3248581 accagcagat tcagctgccc gtcggtgacg ggaatttgga acgtatcctc cgcgccatcc 3248641 cctgtcatat tgatgacctg aaacacgccc tccgctgcca cactggccct tgccgtattg 3248701 ccaagcgtca ccttcacctc ataaaggcca ttcgggagat caacattaaa cgtgttattg 3248761 cttttcgtcc catacgctaa aaactgaacc gcatcactct tcacaccagc cccggatgcc 3248821 gccacatccc tcatattctc cggtgtttga aaaccgtagc cctttgaccg gtcataccga 3248881 tcagacgccc tgacaccaat ataaccaggc tccatcgaac cgcttccaaa gtcaaactga 3248941 tacaccttcg gctccgccgc cttcacattc tcaatcccgc caaaacacag catcagcatc 3249001 atcacaaaaa ccgctgccat ccattttttc atcaagactc cccctctatg aaaacgaata 3249061 cattaatgca tactcggtga ttgtttcttt atgatgactg aattaagaaa aaaattgcgt 3249121 tgaggaataa aaatgagggg agagtctcaa gaaggggaaa atcagtgtga cttcttgtca 3249181 cacttgatca catcccaacc tccgcaatag aagcttattt ggttttcttc gtcatacaca 3249241 taataacgga gtctttccca ttgatcgtca gtcggtacaa tctccaatgc aaccgaatcg 3249301 atggattcaa ggtcatccag ctttgatgca ctaatgtttt caaaccgcaa ttgaatgtca 3249361 caggtttgag cagatcgttt tcattcaaac acaggaatat gaatataacg atcatcttct 3249421 ttcatataga aagaaaactc gtttaatgta aatggacctg tatcctcatc agaaagatgc 3249481 tgtttcaatt tctcgtattg tgtgatattc aaatgaattc cctctattta tatgattcac 3249541 cgccaatcat ataaatgtcc acagcatcgt attcaaacca tatgatccgt tcgcctgagt 3249601 ccgttaggca ttggagcttc ccttctgaaa aatagctttt atccggttga ggatcagtga 3249661 tcagaaaaac atcatcattg atggaagcta gcagaaagag aaaatctgca atatcccggt 3249721 ctgcttcctg taatatggat tggaaatgga attccctttt ggccagcttc gtcaccttgt 3249781 aagcatgacc ttcaaaatac tcggacaggt cttctataaa tgaaccagtc gttattacct 3249841 gtatcatgat tcgatcgtag gcaagccctg cccaaaaacg ataaaacgac tctgcatctt 3249901 caagttcgca tgccataacg gtttggtcag gcttaagctc gatcatgtcc aaattgccaa 3249961 tactgcttat agaggttatt tccataaaat cttcccctta tcagttggat agcgcaacgc 3250021 aaatctcttg tctgacttgt tcatacaaga gaatgtgatg atacagatcc ttatcgtttt 3250081 tgatcatatc cggaagtatg tcaggataca gctcaaaaaa gcttttctcc aacgaacgcc 3250141 gctgatgccg gggtatcctt ttattcgcca gcacataatc caaactgcca gcaacaagca 3250201 taaaaaactc atagatttcc gcttcaaagc cgtacaattc atcagggtac tgcttttctt 3250261 caagctctcg ctgtcttttt ctcagttttt gaagcacgtt gatcctctcc cttccgcaat 3250321 aatctcattt atttcgaaac agaataggcg gatcattatc tatcgcctcc aacagctctt 3250381 caccaaacac agtgattgca catttccacg ggtctcccaa aagtccccag gagaagtcct 3250441 gatgaaaaaa gaaataatag tctccatttg gaaatacggg aacaggccat tcgccaaatt 3250501 catccttagg cattgcctga tgaggactaa aggtatatcc gtcatgctgc caatctagtg 3250561 cgtacattac atcgttcttt ccagtaccta attgaaatgc ttttaaaata gaagtctcta 3250621 aatcacttag cactccgctc acatcattat gaccagcttt actgctcatc gcgcttgaga 3250681 tatcaaacac tcgatatgga tcaggcggga tgatgtgatg acatctgctt ccgggcttcc 3250741 attttatgat cttgttcact tctgaccaga tgcggtcttg ttttgtctga cttaaagcgc 3250801 gccaattcat cataatctca tccctacacc ttattggata tcctgcttat aaacaccaga 3250861 agaggccact gcgtaaacag cgtaacttgt cagtttcagc tgttgaacat ctaggccttc 3250921 accgttcgaa tcacagcatg ttatctcttc catctcttga ctcacatcgg cagaaatcaa 3250981 ataaagagac gacttaaggt ctgcactgta acaattgaac gtcccaacca aaaaaccttc 3251041 ttcggatatc gcgagctgat caaatgcttc tgagtccggc tctttatccg acagaatcca 3251101 cacccgtctc acgaccgttt catcaaatgc ggcaatgact gcatctccgt aatacagcat 3251161 ataaatcaag ccgttttttt ctgcaagtcc ataacaatca tctacagcag gcgcatccat 3251221 ttcttcaagc tttctatcaa tgtgtatttc cttctgctga ccatctaacg taaaacacca 3251281 cacactatgg ccgttgggat tctcatcatg ataaatccct tcatcacata aaccgaccca 3251341 aagctgttgt ttctaatcca aaagacagca ggaaacccct gaaggcaagt gaaaaacact 3251401 tttcaccctt ccctcttctg aaaaaacctt taccttcggc tcgtacgatt cgtaataaac 3251461 gaagacatag ccatctgcac attgttgaaa gagcagaata tcactgtatg aaatctgctc 3251521 tttcactcta aaatcccgaa catcaccgga aggatcatag attgtaatgg tgataccacc 3251581 tttcaaccct tttccaatgt agacacgccc ctgtggatca gcatggaaaa aacaatcttg 3251641 ggtgttctcg ttgatgattt tattcaattt taattttttc attggttatg ctcctaggtt 3251701 cgaaatgaaa tgataagaat aaaccattta ttagctatta gtaacggaca acctagtttc 3251761 attaatcgtt ttgggataaa tctactttcc aattcagcct taaatcattt agtgtttaat 3251821 tggtatgcat aaaacgattg atcatcaaag cgaactgttt cagcttctat agcaatcagc 3251881 attctgttca tgtcaataag aaagttagca tttgattgat actccggaat tatagaattt 3251941 gatagattcc cgattccttc tggatgataa ctcatctcaa atacttgcca attgtattct 3252001 tccggatcta ttttttccaa tctcatgtcg ccaacatctg cactataata agcggatgcc 3252061 acattttgaa atgaaatttt atgcgtatat tcaccttcat cttcaaaaac cttaatatca 3252121 agtgagagtt cttttttaaa cacattaaaa tctaaatgaa ggacactgca ccccttatct 3252181 atataatcaa cccattcatt aatcgtttga tacattgtca tcccctgcct ctttttaaac 3252241 aataacgcct tgccaccaag cagaaaacaa attactccgt atattgtttg atccaatcat 3252301 ttaaatcatc tgttgaatgc aaataagttt ctgatgaatc tttcaaatca atcccactta 3252361 gaaggattaa catatcccag actctatcgt cttctacttc ggggtcatcc gcataaacat 3252421 aagttccagc ccaatccgac acttcttctc ttgttgtttg tccatttaag acacttttga 3252481 ttttatttat gcattctatt agatttgtct cgctcaattt gatcaccacg tattcaagta 3252541 ctaaatgatt ttttattagt atgcaaagca ccgtactgat atttagatat tgaagctttt 3252601 tccgtaaaag atatgttcca aaaggtttcc aatctaccaa taaacaagct cacatccgta 3252661 ttccgtgtgc aatatacata aaccaaactg gcacttaggc tcaaccaaaa taaaactatg 3252721 attgagaatc ccttcatcga actcaataca ctccaataag cagtcaaggt gctcgagaca 3252781 ttttccaaaa gaacaaacta acgcaccaat ttcgctgctg tattgatgaa acagcagaac 3252841 gtcccggtca tcgtaagcaa catatgactg agatattttc cagatcagct gtttcgcttc 3252901 cgttttttcg agggcatcaa cctcacgggt gttggctggt attgaatttg ataaaaccag 3252961 ctcaagcaat tgcctgcttt gcgccagatc agcaaaacga taagtgaagc ctctttctgc 3253021 acaagggact agtttttctt tgatttcgct catcaataaa cgtcttttat tctcggcgag 3253081 tttttcgatc aatctttttt gcatgagccg cattccctcc gctgtcaatt tctcaacttc 3253141 ttttaaattg attcatcatt ctcttgtttt cgttgtcgtt catgtttaga tttgttctaa 3253201 aaaagcttgt atcgcttatc gatacaagct ttatcttcaa ctgcttaaaa ctcacccagt 3253261 gggcttttca caaaacgctg ggaacctttt tggcaaatcc tcttcatccc aatcaattct 3253321 atatttttag attcttttgt catacaaata agagaggatg gtaacatctc ttatttaatg 3253381 ttccatcaat aaatgcccca tttttatcca atgcagaaat tatttataat taaggaagtt 3253441 tagaaggatt ttttgtattt tcaagattta attttaaagc ggtcacaaaa gactctagct 3253501 tttcttcatt acaattaatt tcgaacaagt tggagttcga cttactttct ttataatcat 3253561 caaatataat tttaatctta attctgtaat ttccgttttc ttgatcaata ctaagaaata 3253621 agaatggttc aatagtctct aaactgatac tgtcttgatt tccttttatc atagtttcga 3253681 tcccagatat caacacctta tattcacttt ctaataaaac agcagaaaaa tcgcgaacga 3253741 cggctttctt attttccaac aattcaaata cagataaaat aaatggatca tcgtccaact 3253801 cttgatacct tctcggtgtt aattcaagtt ctatacaatc atcttttatt ttggccatat 3253861 ttcctcctca tttaaagttt aagtgagggt agttgtcatc cccccctcgc ttaaccttat 3253921 taacgccttc tcttagattt atttcctttt ccgtgtgtat ggaatacgtg tttagaaccc 3253981 ttagctcttg aacttccata agctgtgatt actttacccc ttttatttaa aacaactgta 3254041 gctttttttc caacatattt cgttgcccca ttaggttgtt ttattacttt tttagggctt 3254101 cgcacagcat tcagtttggc ccttaaattg actccacggc ctccatttct tcctatagat 3254161 tgattaagtc catgtcttgt atgacctgtg attttaactg ccttcttcgt aaacttatag 3254221 gcgcgactag cacccttaaa tatcttccca ggaccaaaat tagaagcagc tgcccaagca 3254281 gcacctttcc atcctttacc tgatttatat gccttatatc catcataggc tgcaaatccg 3254341 gcatttacca caagccatac ccaatgcccg tccggatcaa cattcatcac tgggttatta 3254401 tttccataag catacccatt ctgatccaat gaatctccgt cgctgcccgg gtctgggtcg 3254461 agcgatagga acacgccgtt tcttggctcg tagtagcggg ccatgagata gtacaggccg 3254521 gtttcttcgt cgtattggta gcctgcgtag cggtagcgat tgtcttttac ttcgtcgctt 3254581 gcttcggttt ttgttggatt tccccatgcg tcgtattgat acttggcaac ggtttttcca 3254641 gtgctgtctg agatcgcgat gatgtcgccg tgagcgttgt agtgatagaa atatttctta 3254701 ccattttctg tgtaggataa cagctggccg ctgtctccgt acgtgtatga ttttgtgacg 3254761 ttgttgtccg cgtctgtttc atacaagacg ttcaagctgt ctccgtcgta gaagtagttc 3254821 gtgacttttc cgttgacggt tttttggatt ctgtttcctt tttcgtcata cttatatgtt 3254881 gcgaatggct tgtcttcgcc ttttttggta acggcggtca ggttatcttc tgcatcccac 3254941 gtatatgtga atttgccgtc ggatgtgcgg ttgccgtttt tatcgtaaga gatgctttca 3255001 tcattgactt ttgtcagctg gttcatgatg ttgaaggaag cgttcaccgt tttgcttgag 3255061 ccgtctttta tagttgtaac ggttttccgg tttccgaatc catcatatgt gtattcaata 3255121 acagtaccgt cttcatgggt ttctttgaca agctgattca gcttcccata ctcatattgc 3255181 accttgccgc ttgctgagct gtttatcgtt gtgcggttgc cgttggcatc atattcatag 3255241 ctttccgtca gaatgtctcc gccgtttttg tcaccgatat gcagcgagct tacaaggttt 3255301 ctttcgtcat atgaaaaact tgttccgccg ccgttgcccg taataaaggt ttggacgttt 3255361 ccattttcat cataatcaaa tgaatatgag gatgtactgt ctttcatctc aatcatttga 3255421 tccagcttgt tatacgtaaa ttgattcgtt cctttttggt ccccatgaat ccacgagaag 3255481 gttttcagct tatcggagtc actaggatat gtccaagttt ggctgccgcc gcggtctgtc 3255541 agttcggtta aacggttttt gttgtcaaat gtccgtttct ttgtggtgtt ctgctcttta 3255601 ttgacgaccg acgtttcatt tccatttttg tcatacgtga aaatgtactt ttctgtaccg 3255661 ttatacgact ttgatttcac ccggtctgtt ccatcataag aaagagacac ttcgttgcca 3255721 tttggtgaaa tggttttggt caggttgctg ttggcatcat attcgcttgc taacacattg 3255781 ccgagagggt cagttgtttt gacaagcttg cccatgacat catattcgaa tttataggtt 3255841 tgatctgctc ctgcccggat ggttttgctt acctcattgc cttccttatc atagctgtga 3255901 aggatagacg tgccgttaga gagcgtcatg tttgtcaatt ggtctgcctg atcatacgta 3255961 taggttgttt tttcaccttt tgcatctgtt tcagacgttt tcttaccagt ttcatcgtaa 3256021 tcagttgaag tggcgtaacc tagttcgtcc tcttccttgg tcacatagtt gccattactg 3256081 tcatacgtgc ttttagtcag aaggcttcct tcaatcaaac ggatatcatc aaaccagact 3256141 gtgcctgtcg cactcttttg gaacagaata ctgatatcga ctttattgat cggctttgtt 3256201 ttagggatga cgacagctgc tcggttccat tcctgtgttc cagaagggaa tttcgcattg 3256261 tagatgcctg tgctgccgtc agcgtaagtg acattcgcct gcagagaata gtctttttca 3256321 tctgtaaatt tgacgctgct tgctttcgac attcctgtca gtgtgagata aaccggtttg 3256381 tcatttgcgc tttgccctaa gacaacggtt tgttttgtta ctgatccggc ttgggacgca 3256441 ctggtccggg cagcttttaa tgatacatca tcattaaagc cttcttcaga atcaacggat 3256501 gctccgctta cattccagtt ttccgttgct gatgtgaagc tgctgttttg aactgggtta 3256561 tagcttgatg atacttcgcc tttttccagc tggacttcat caaaccatgc ttttcctttg 3256621 ccatctttat ctttatgatc gacttccata tacacaacag ctttgcctgc attcgctgga 3256681 gtcgtaaaag tgatttgccg ttttgtccag tcattttttc cggctaatgc actgtattca 3256741 ttgtgaatcc attgaattcg tttttgatct ttgtctcgca aatcaatgtt aaaataggct 3256801 cttgatttcg caagatctgt tttgattttc ccgcttaatg tataggttgt attcggctcc 3256861 agctcaactg tttgtgttgc tgacgaatac ccatgatctg ttccggcaga cgttgattgg 3256921 ctcaagacct ccaatgcctt tgatccggaa agaactccgc ttttatcggc gatgactgaa 3256981 attttgccgc tgtctttaga ggcagtcaga ttccagccgg atttttgagc ttcaaagctt 3257041 ccatctttca aaatattagt tgaagctgat aaatctttgc tcgattgaat ctggtttcca 3257101 tatttatcat aaacagctgc tgacgatgat tttccgctct gatcggtttc ggatacagca 3257161 tccagtccgt cataagcaat atccgtgaca ttgccctcgg tatccttcat ctttgtgaca 3257221 tcgttgtttt tgttgtattc gtatgtctca gttccatatg catctttaac cgacgtaacg 3257281 ttgccatctt tgtcatattg atagctttcc gttgcttttc cggtgccgac gtcatttgga 3257341 tctacatctt ctacaacatt gttgccttca tactttgtat tcgttgtaat ttttaaccct 3257401 tccgcatcat caatgacctg aatcggattt cccgcttcat tatagccata ctgtactttc 3257461 cggccatttg gctgtgtcat gagaagcgtc tttttatcag catcatagct gtagacatat 3257521 gtttcttttt tagcgttgat cgctttttcg agacggtgac cgctatactg atattcggta 3257581 aagacaggct ttgcttcggt actgttagct gaatattgtt tgacaaggcg cccttcacta 3257641 tcgtagtcat agcttgtgac agtcccgtct gtatctgtaa ccttcttcag caaatcattc 3257701 tcatatgagt aggtgacttt cttattctta ggtcctgtga tggacgtcac atggccgttt 3257761 tcatcatagg taaatgtaag cttgcggcct gatgcatctg taatggcggt cagttgattt 3257821 ttgtcattgt aagtatagac agttgcattg ttatggccat ccactacctt ttggagtttg 3257881 ccgccttttt tattgaaata agcgttggtt tgatcctttg tttttaatat gaactgatca 3257941 gctgtttctg ttaattcaag atatacaccg gtcggcggct gatacgtgcc atcggctttt 3258001 ttcgtgaatc gatgtgtcgt agcgtcttca tcgatataca ttgccccgcc atccgttgag 3258061 atgacagatg tttctgcatc agcataccag ccttgtccaa ataagtgatc agagctgtca 3258121 agactgttgt aggttctcga taagccaagt cccggaccgc gtccatcaat tgacaaatct 3258181 tcttcattca caatgacatt gcctgtcgca ccatttaact ggccgcttgg gatatcaatg 3258241 atagaccagt actcttctgt acctaggaat tctgcgcctt catggaacgt tgggttaaag 3258301 ggcgccgttg gaatcgtttc accattcgca tcataggcga caagcgtgaa agaataattc 3258361 ttcttccctt tgtaattccc atttgcattg ttatagacag gtgatggatc gagggctaat 3258421 tccccgcctt ttccatctgt atgaagctta tagcttccgg ctttgatttc ctcagaagtc 3258481 ggccagatgt ttttattttg ggttgtccaa tgatcagcat caccaacatc aaaggactga 3258541 tattctttac cgttgtaaat gttaacttta tagcccttcg cattttgaac cttttcccat 3258601 atcaaattca cataacccgt ttgactcgat tttgtatttg tatacaaata gccagttaca 3258661 ttctttggcc tagcgatatc aggaagtgcc ggggtagcag ccggggatgc aatggcttcg 3258721 ccgtctttgt tgtatgcgat aattttaaac gagtaatttc ttttggctcc atctcccccg 3258781 gcgtttttat aggttggtcc gggattgatc ggcagctctg ctccgcttcc gtcctttagg 3258841 tgaagagcat attttcccgc cttgatttct gcacttgtcg gccagatctt tttccctttt 3258901 gtggtccaag acgtctgatt tccgagatca agtgtctcaa agcctttccc attgaacacc 3258961 tgaaccttat agccggttgc accggataca gctttccaag aaaggtcgaa gtatcctgtg 3259021 gcattcccat tattgtagcc ctttgctgac ggtgcttgtg cttttcctac attagggata 3259081 acgggctttg ccggtgcgga catcgctcct tcaccttggt caaatatcgc actgacgcca 3259141 atccaatagt ttttgcttgt agcatagctt ccgccggaat tcttatagac cggggatgga 3259201 tctaatgcca attcagctcc atccttgccg tccagatgca gtttatatct cttggaggca 3259261 atttctgcgc tcgtaggcca gattttttta ccttttgtgc tccacgacgt gacgttgcct 3259321 gcagaaatcg cttgatattc cttaccattg taaatccata ccttatatcc ttttgcgcct 3259381 tcaacctttt tccagctgat atcgaaataa ccagtggaat cgccgttgtg ataggctttg 3259441 attgtaggtg tgtttccctt tggaatggta tacgtcactt caatatatgg tttattggcg 3259501 gagttcgctg aagaaattag ttttttccaa tattccttgc cgtttccgtt tgtatgaagc 3259561 ttaaatccat agttggcccc gccggagttc catgacttta cagcagcggt cacatcataa 3259621 ctcgcccact gtcctttatg gacgtcggct tttccgatat ttttagatgc cggtttggtg 3259681 ttccatgtca cttttgcatt atcataattg ctgttgaccg tatccagcca aaggccggtt 3259741 gcctttgttc cataatagga atgggctacg tatgttttta atgtagcttt agtgacagtc 3259801 atattttgaa ttggctttag gttgttaaat ttcatgaacg catagtttgt gcctgttgtt 3259861 ttgtcataat agcccgtttt cagtacatag gcctttaaat tagcatccca tttttgtgag 3259921 gaggccgaat agttcgtcgt cgggtaggca ctcatgacaa acgtatccga tgaaacagat 3259981 aaagaagttg acgggtcgat agatactgga tatacgcgtt ctgggtcttt cagccagttc 3260041 tcgtctgccg taagatgaag caaataccct tcttcattct tttccagctt atagctgact 3260101 ttgtctgacc gttcaacctc gccggaaagc tcatctagtt ttgaatccgt cataaaaggc 3260161 ttaggcacag aaaaaacaac ttttcctttt tcatcagaaa aatcaatgga tccatcctct 3260221 tgttctttag cctgcaaatc ggtttttaac tgaaatgtaa atgtgttgta tccattatac 3260281 tgatgaagga ctaaatcttc ttttatgttt tcattgaatg tgaaagtctg aagatcaata 3260341 ttcggaaaca catccggata cacaatctca ttactgtcag tcttataatc tgctgaggta 3260401 tctttcggag taagtgaagt tttattcggg cctttcgctt ctgctagtga atatgtaacc 3260461 ttatggtcat tatgctcaaa agtcgcataa agcccgttct tcatttgctt ttgaaaatct 3260521 gaattcaaaa tagcgttctc tgtctcgact tgtttgcttg tcgactcttt taactcagga 3260581 gaaatgtctt cccagtcggc atccggtgtt tcctttgtat gaataggatc aaggtatact 3260641 tcctgtttat agacaccgtc accttcataa tagagttttg tattttctgt tctttcagag 3260701 gtgatctcac cctctttgtt tatatctttt ggatcaaaag gtacagcttc ctcagtttgt 3260761 tctttctgaa gagtttcttc tggatcatcg gcagcaatac ggtttccatt ctcttcttct 3260821 gtagattttg ctagtacatc ggctggcact aatgaaatca ttaaagccaa cactaaaaat 3260881 gctgcaatga accttttaaa gtttcgcctc tttctttttt tcatttcctc tctccttttg 3260941 taataaaagt aatatttact caataatctt aactagactg aaatatcatt acaatatttt 3261001 tctagaaaat ttatcttatt ttaaggatta gcgagagtca attgacctaa aacaaaaaaa 3261061 ggccgcatag gcctttttac attttttatt gtatttgttc aatatccgta ccctcagctg 3261121 tcacattcgc cttcccctgc ctcctgacaa gcgtcaaggc catgcccgca aagatcatta 3261181 cgatgccaag cgtttgatag aggtcagggc ggaagcctgt gaagacggta tcgagcacga 3261241 tcgcgacagc ggggtcgaga aatacaatga ttgaaataaa tttcgttgat aaaaatcgta 3261301 aactgtcaaa aaacagcaaa tatacaatac ccgtatggat gatgccggta gataccacca 3261361 taatccagtt tccctgagat aggtccgcaa aagcgccaaa gtgaataaac ggaatcagga 3261421 tgataacccc taaacctgtc tgcaagaagg tggtcgtgta aggactgaga ttgtgaatgc 3261481 cttttcccaa taaagtggtg aacgcataaa acagtgcggc gagaactgcc catatgatcc 3261541 ctgatcccat cagctgtgtc aatgatgtgc tgccgttaat cccggaaatc agcgcagtcc 3261601 caagaaagca gatgataatg gagctgacgg agatcacatt taatttctct ctgtagaaga 3261661 agctccccag aagaagaaca agcaccggcg ctagatgata aacagagatg gcaattgtaa 3261721 cggacgtttc ttcaaaagac ttaaataaga acacccagtt gaatacaaga aagaaaccgc 3261781 acgccaatgt ttgcagcacg tctctcttgc tccatttttc agttttatac tggccggacg 3261841 ccagccagca aaagcctaaa aacagcgtcg cgcaaaggca gcggacaaag accaattcaa 3261901 atgacggcag attggtatgc tctgagaaaa agccgatgga gccgaaaatc accatagaga 3261961 tgaccatttt gattacggct gttgattttt gttttgacga tatggaagga tcctgttgca 3262021 tcaaacgtat tctacctcca atactgcata gcataaactg ttttttgtga attcagaaat 3262081 ctacacatag aattcctctt ttttacatgt agatattata acacttctat tctaaataaa 3262141 aaaaagcgcc caagggcgct ttttttacaa atctatcgaa caatcaaaac cgggcatgtt 3262201 gataattgag acactttatg gctgacgctt ccaagcatca tttctttcag gccgctgatc 3262261 ccccggctgc caactacaat caggctgacg cctttctctt ttgcgtgatt tagtatctca 3262321 tgcgccggct cgccattcgc gtaaatggtt tcagcttgaa cgcctttttc ggctgctttt 3262381 tcttttgcat tctcaaggat tttcaggccc tcttttttaa cctcgttcct gatttcatca 3262441 ataaagtgtt caggcacata gacaattccc gtcagagaag aagtcgtgac gacggcttct 3262501 ctccccacat gaagaatgct tagttccgct tgttgctctt ttgccaaatg cactgcggca 3262561 tcaagcgctt ttgcactcat gtctgatccg tcaatcgcta ctaacatttt gttaaacatg 3262621 ctcttcccgc ctttcggact gtgggtggtt catctttctc ttttattgtc cgcctgcatt 3262681 tcgttattgt caattgaagc gcatgagttt tcaaaaaatt gtcagagact ctctccgttt 3262741 gtggcgataa cctgctgata ccagttgaag ctttttttct tgatgcggtt aaatgttcca 3262801 tttccttcat tgtcccggtc tacataaatg aagccgtagc gctttttcat ttccgcagta 3262861 gatgcgctga caaggtcaat tggcccccat gatgtgtatc cgattaattc aacgccgtcc 3262921 gcaatggctt cgcgcgcttc aattaaatga tcacgcagat agttgattct gtaatcgtcc 3262981 tgaatcgtgc cgtcctcttc aaccttgtct acagcgccaa ggccgttttc aacgatgaac 3263041 agcggcttct ggtaacggtc gtataaggtg ttgagcgtga tgcgcaagcc tttcggatca 3263101 atctgccagc cccattctga tgatttgagg taagggtttt tgactccgcc cagcaggttg 3263161 ccccctgatt ttgcaagctc ttccggatct gtgctcgccg ccatcgacat gtagtagcta 3263221 aatccaatat aatccaccgt atgttctttc aagagctctt catcgccttc agccatttca 3263281 atttcaatat tgttttctgc cagatagcgt ttcatatatc ccgggtatgc gcctcttgcc 3263341 tgaacatctg agaagaaaag tgttttgcgc tcattctcca ttgccgcgaa gacatcctcc 3263401 ggcttagaag tcatcggata ggttgtcgtt gccgctatca tacagccgat tttcgaatca 3263461 ggaatgatgt cgtgacccgc tttgacagca agagcactgg ccacaaattg gtggtgtgcc 3263521 gcctggtaca tcgcgtttaa tttgttttct ccttcttcaa aaacaagacc gcctccggta 3263581 aatggcgcat ggagcactac gttaatttca ttaaacgtca tccaatactt cactttgtgt 3263641 tgatagcgtt tgaaaaccgt tttggcatag cgttcataaa actctatgac tttgcgattc 3263701 ttccagccgc cataattttt cactaaaccg agcggcatct cataatgaga gatggttacg 3263761 acaggctcaa tatgatgctt taacagctca tcaaacagat catcataaaa tctgaggcct 3263821 tcttcattgg gctcctcttc atcgccattc ggaaaaattc tcgtccacgc aatcgatgtg 3263881 cggaacgcct taaatcccat ttctgcaaat aaggcgatat cctctttata acgatgataa 3263941 aagtcaatcc cgttgtgata cagattcaag gaagtcattg attcatcaaa tggagacatg 3264001 atcccgttcg gcgatacgtc agctgtcgaa agccccttac caccctcgtt ataagcaccc 3264061 tccacttggt tggcagcaac tgcgccgccc cataaaaatc cttctggaaa tcgtttttca 3264121 tttgaactca tattgatcac cccattagtt ttttcaagat aaagcaagca gcgcttcttt 3264181 tggctgcact ttaccgatct ctttcaccgg cgaaaacgaa tattggtctg tgttggtcac 3264241 aatcaccggg gtaatgacgt catatcccgc ggctttgatt tgctccagat caaaggacac 3264301 gagcggatct cccggtgcga ccttgtcgcc ttctttgatg tgagccgtga accattgtcc 3264361 ctccagcttt accgtgtcca atccaatgtg tatgagtatt tcagctccct gatcactcgt 3264421 aatgccaatt gcgtgttttg ttttaaaaat ggtggtaacg cttccacgaa caggcgaaac 3264481 aacttctcct tcttcaggct caatggcaaa tccttttccc atgaccccag cagaaaacac 3264541 tccgtctttg acttcactta aggctttcac ttctccctta atcgggctgt gaatgatctc 3264601 tctgctgcct tcatgcactg ccggctgctg gctgccgtca gaaggcacat cctcgaatcc 3264661 aagcaaatac gcagctgctg ttcccgccgc aaacgcaatc acaaggccga tcatcgcgta 3264721 aataaacgtt gggccgataa agacagggat gctcggcaga cctgcattcc ccccgacgat 3264781 ataggaagca acacccgtca tgccgtaaaa cgcgccaccg gctgcaccgc caatcaaagc 3264841 ggccgcaaac ggctttttca atcgcatatt cacgccgtac atcgcaggtt ctgtgatccc 3264901 catcagcgcc gtgatgcttg tggtaagcgc gagtgattta aattttttgt ttctagagcg 3264961 aaggaagacg gcaaatgatg ctcccgcctg ccccatattc gccaaaaaca tagccggcag 3265021 taaataatcg tggccgtttt gagcgatgtt gttgatcatg atcggcacaa aggcatagtg 3265081 catgcccgtc ataatgatta aagagaatgt acccgccagc aaaatcattg ccacaagccc 3265141 tgcatgatca aacaaataat tgaccccaga agacaagtat tctcctaaaa tagcgccaag 3265201 cggaccgact gtaatcaatg tcagcggcac gacaatcaat agcgtgaatg tcggaaccac 3265261 aatcaatttg agagatgcgt gtgtaaaacg gtcaatccat ttttccacgt atgaagcaat 3265321 ccaaatcgac agcaaaatcg ggatgaccgt tgacgaataa gtggcagcgg ttacaggaag 3265381 cccgataaag gaaatcggtt tccccgcacc gagcagggct gtcaaatccg gatgcaggat 3265441 cgccgccgca atggcagccg ctacgtacgg attgcttccg aattttctcg ccgcactcat 3265501 cgctagcagg agcggcagga agtagaacgc accgtcaccg acagccgtca aaatgacatg 3265561 aacctggctc ttctccgcca tccagccaaa cgtgactgcc agcgccacaa gtcctttgat 3265621 catccccgct cccgcaatcg caggcagaat aggggtaaac accccagaaa tcacatcaaa 3265681 gaccgcactc agcacattct ttttctgaga ggatgaacca gcgctctttt catcactgag 3265741 attgctgtgc cgcacaatcg cctgatacac cttcggcaca tcgtttccga taatgatttg 3265801 aaactgctcg ccgctgatat tggtgcccat cactccaggc agctgctcca gctgactgcg 3265861 atccgccttc gcgttgtcat gaagattaaa acgcagcctc gtcatgcagt ggatcacgcg 3265921 ctgaacgttt tcttcaccgc ctacgagttg taatatgtcc ttcgataatt tatcataatc 3265981 catgtgtata cctccttttt atggggggac tgctggatga aaggtggccg cctttcacca 3266041 gctttttttg tatcaaatgc tgcatcacct cctaaaagag aataaaaaaa cctaaatgac 3266101 acagattgcg agagtctcct cctgcacctg caccatttag gttttgcctg ctttcgcagt 3266161 aacaatcctg acgggtcgtt ttatttgttt gtaggtatac tttagcacta gattcgtgag 3266221 atgtcaacgc tttcattttt ggtgttgact atcgtttcta gaacaaaagt aatcataaag 3266281 atttgaactt agtattaact tcaataaaaa attattgtaa ttaaaaacct tgaaaggcat 3266341 tttttccaat caaggttatg aatcgttacc gtttaaattt ttttaaagac ttctttatct 3266401 gtactattac attctttagc caatctattg gttctaaatt aaacgcagga agatacacgc 3266461 catctgcgca agattgaatg taatcgtttt tcttattgtc tgaatgctca ctttcaataa 3266521 aatccgttaa aaagacaata gcatcctcca aatattcctt actttcctct attaataact 3266581 cttgtatagc gtcatcagga gtttcaatat cttgatggaa tgttccagct aaaaactgaa 3266641 aaacagggtc cttctgttta ttgatcaata acatgtcatc ttgctccttt aagggagagg 3266701 taacgggata atgttaaaat cattcatcat ctaataaatc aagataatac tgatcattct 3266761 cttctatttt tcttaagaac tcggtaagag aagttgcaat ttgaatatca taatagtaaa 3266821 tcggattttt attattatca tttaattcaa ttgacattaa tgccgattca ctaccttcaa 3266881 aaaatattaa tttatcattc tcaaactcat catatatttc tatgtcagga taaaattcaa 3266941 agtcatttat cctcaatcga aagtctctta cagaatatgg atccaaaatg cgattagtat 3267001 taaactctga tcctttaata aacccatagc caacttctaa ataaaaattc actaattcac 3267061 taggtaattt taagtttaaa tttttttcaa cctcttcaat ctcactttga ttcactggat 3267121 aaaaatcatt ttctttgttt gattttataa aattataact catttttttt tgcctccttt 3267181 aaataattca tttgctggtg agcctgtacc atgaatccca gcttgatgct cgttaggaaa 3267241 ttttgctgga tgcatattcc accattcatg ttctccgcca aaagtatttt caattatatg 3267301 gtgagcatca tacttatccc ctttttttct aataatttta cctgtttttt cagatacaac 3267361 attttcctta taaacaggcc atttttgtcc agtgttttct tcccattctt ttataacttt 3267421 attttttact ttatcaaatt tagtcctgtg ttttgcagtc tctattggtg acattttttt 3267481 atattcttta tttcttaatg cttcctttaa tttatctatt tgatttttag gtaattctct 3267541 acctgtgcgt tgttctatat ctctagcata cttttttatt aaatcagaat taattttatt 3267601 agcagatcca cttacatcat tcgcaatttt ccctttatcc ttagcaacgt ttttaacttc 3267661 cgaagccttc ttagcctttt tcccattatt aataagttta ttaatatcta ttaacttttc 3267721 taacttagct attttggcaa atggtactga gtttatggag gcaacaacac ggtctttccc 3267781 tgtgactttt tcgcctgata ccggatctct gcccgtggct gctttaaata gatcatacac 3267841 gccggtaagt tctacagccg tctctaaaat tttcacatat ccattctcat ccactttaat 3267901 gtccgaaagc gagacgacag gttcaagctt catgtcatta ccagatatgt atacattgta 3267961 aagtgtatca ttataaacga cttgcttaac ctctgcattt gagaaatcag tttttatatg 3268021 ttctctatgt tcactcgtat tatacacttt accattgata acgatgatat ttttacttac 3268081 ctttttagaa tcacccgttt tgacaactga atccacttta gacttttcat tctcggctaa 3268141 tttcttcagc atcatctcca tcggtgaatc atccgcctgc ttcatttgcg ggttaatcgc 3268201 gccgaagatt tggttgatgt tttcttcttc ctgtgatttc aggatggagc cgcttttgta 3268261 gcctgtgatt tcaattttcg ggccggtgta catggtttcg agctgatcaa tgtatttttt 3268321 catcgtttga aaatctgatt ttgcggcttc tagtgcttgg gtttgctggc cgtcaaattg 3268381 aaagagctta ttcagggtgt ctgaaatcag ccgctcagcc tgttctgttt ccatccgaaa 3268441 aaaggaatca ttgactgtcg gcaggctgac gatgtgatct atggctgatg tctggcgatt 3268501 gactgcgtca gtgagctgct ctgtcacttc tcgtgcatgc ttgaccccat gtctcgcatc 3268561 gtgtgagaga aaagcctctg cgatcatgcc gtgggagtta gattctacag aggaaatcgc 3268621 atgctgtgtt tgtttcagca cttttttgta ttcgtcgata aatatgccaa agaaaaggag 3268681 aaaaggcttg tggcactcct cgtaaaaggt ccggatggca tctccgcctt ttcctttcag 3268741 cgcatccttc atgcctgcca gatgctcaac gcttttttcc agcttctcca gctgttgttt 3268801 ttgcttgtcc agtttctcaa tcgtatgctg aatgccctcg tgaagagcgt ggacatctaa 3268861 tgttttcaat cccttgtcct cccgcgcttt atttcatgga agatgatatg ttttcgtccg 3268921 tttccttcat ggcgtttacc gcgctttccg tttgtgcgat atgcttggcc agaacagacg 3268981 catatgcttc agtgagctct ttgatgtcct tatttaattg ctcgatggac ttcacaacat 3269041 tcaaatggtt tctgcctgag agatgaccgg gcaatgagga cttgagttca gctgaattct 3269101 tgagctgaga aagcccttgc ttcactgtgt catacaccat tttaatttcc tgtgccattt 3269161 gtgctcacct cactttttat gtttttcctt ctctatttca tgctctatcc tcgtgatttg 3269221 gcgtcttata gaatacacat cgccctctaa tgagtggatt tttccttcta tgctttcgat 3269281 gattccgctg acttgatcgc ttttgatttg ctgatatgct ttgttcattc cttcacgaat 3269341 atcttcaaac cgctcagcat gtgttcctct ccatgcctcc cggttaagat gaggccggtg 3269401 aatgagatgc tgggcctcag agaaatcgtg tttgatttgc ctaatttcgt gcagcactcg 3269461 ttttaattga tggatctgtt cctgcttttc atgtaagtcg gcttttaccg aatgtaacaa 3269521 catttcacta tgcatgccgc aacacctcgt gtttctatca aactgtgtaa attctttaca 3269581 atacagacta ttttcatatt acatgatggg tcatattgga taaataggta aaaaggattg 3269641 tcttgagagg tatagaactg gttctaaatt gctaaaaata cgatctcatc accctatgaa 3269701 aggagaaaac aatcatagta gggacttttt atttaagcct ttaatctctc ctccagttct 3269761 aatttttcct cccacttaac tgtttcttat agtcaataaa gctcataaaa aaacaccttc 3269821 cctcgaaggc gcttctccat cttatttaga tccccataca gcctcaccgc tggtattcag 3269881 cacactaaac gtcatgacgt tcttctctct caccgaatcc cactggcgta aaaatacccc 3269941 gttatacttc ttgcctgcta acgtgatgtc ggcggtgttt tttccggttt tcctccatgt 3270001 tccggtcatt tccccggaaa tggtgtggtt tttgttgagc tggatgttga tggtttgttt 3270061 gatgtcggct gagatgtctt ttccgtgctg gataagtttg tatgttcctg tgatgtcttt 3270121 ttgttttact tctttcaatg tttcgcccgc ataacgatat ggtgctgcta ccggccagcc 3270181 gtctttgttc atgaacaatt ggtggactct gacttcgtgt tcttcacccc tgcccgggaa 3270241 gcgggtgtgg aagattaaat aggaacgccc ggttttttca tcatagtatg cggagttgtg 3270301 gcctggtgag acgtacccgg tgcctttttc attttctgtt tcaaaagtgt agctgcccat 3270361 gagtttgacg ccgtatggtt cgatggaacg gtcgtcgaag aatgtgcctc ccttgccgcg 3270421 gacgtcgagc attggattgc cttctgcatc atagtaaggg ccgtccggtt tcttggagcg 3270481 ggccacacgg atgttgtagc cgcctgttgc atcgagaccg ccatatgata ggtataagta 3270541 gtagtattgg gtgtctggat tgtagagaac atacgggcct tcgattctgc tgtggttgcc 3270601 gccgagcagt tttttcccat atccctgtcc aggaagcggg aagcccgttt tcggattcat 3270661 ttcaagtatg aaaatgccgc ctgagtatga tccgtacacc atccacagct tgccgtcttt 3270721 atcaaagaag gtatgcgggt cgacgacatt cggatgtttg gttgcatcat acggtgttcc 3270781 atcgctgctt gtgccttcca ttcctgattt caaaaagatg cctttgtttt tgtatgggcc 3270841 ttcgatgttg tcagcaacgg caacacccat ggcggatctt ggcgaatcgc cgcggcaggc 3270901 gttgtagtac atgtagtatt tgccgtccgc cagctgcgtg acgtcagccg cccaaagagt 3270961 atcggattgc gcccattcga aggtttcttt taattcttca tagacattcg ggataagtgg 3271021 gttgtcattg cttacgctgg tggtcagctg ctgccattgc atgaggtcat tcgatttagc 3271081 tgaagcgaga tgagatccaa aaacataaaa agtgccgttt gtttcaatga tggaagggtc 3271141 atggacgctg acttctttaa atataggttt ttgtgcatag acggagtttg ggagggtgaa 3271201 ggccatgata agagctgcaa gaaaacatac acggaacaat cggttgaaca tctaaacaat 3271261 tcgcctctct tttttattaa attttaaacg cttacatttc tctatgaaga taccccggcc 3271321 tattaaaaca gccgaatgtt ttcatattca tccagatagg tgatttctca cttcacttac 3271381 atagtcagac tgatgtctgt ctgttttgcg cagaacttgt tgcttgcata tcctctcctt 3271441 catagttcaa ctcttttgct gtttctcctt cttgcatcac gtctgttttt ctttcgcgta 3271501 catgtaataa ctgctttgtc aggttttgca tcaactgtga tacagccatt tcgttgtcgg 3271561 cgttttttaa gatgatgcct gattgcccgt caacaccaga gtcattcggc tggctcttta 3271621 taaaacgcct tgcgaaaaat acgacttagt aaacgcatat tgagagttag acagcggcgc 3271681 ttgcctcctt gtctggatat cgtgtgcaat cgctgaaaaa acctgttctg ctttctgcgt 3271741 cacgctatta caatagcaat ctaacttgtt aaagactata aaaaaacctt ttgacttctg 3271801 ctgctgaacc aattaatata atactcagtt aatagttatc agaattttta ggaattgagt 3271861 gattcatatg acactgcata aagagcgtcg gatcggccgg ctgtctgttc tcctgctgct 3271921 gaatgaggcg gaagaaagta cgcaggttga ggagctggag cgagacggat ggaaggtctg 3271981 tcttggcaag gtaggatcaa tggacgcaca taaagtagta gccgcaattg aaaccgcttc 3272041 caaaaagagc ggtgtcattc aatctgaggg ttatcgggag tcacatgcgc tttatcatgc 3272101 gacgatggag gctttgcatg gcgtgaccag aggtgaaatg ctgctgggat cgctgcttcg 3272161 gacggtggga ttgaggtttg ccgttttgag gggaaatcct tatgaaagtg aagcggaagg 3272221 cgattggatc gctgtctcgc tttacggaac aatcggggcg ccgattaaag gtcttgagca 3272281 tgaaacattc ggcgttggaa ttaatcacat atgaaacagc ccatagatct tagacgatag 3272341 ggggctatgc gtgaaaacag aagttcacag catagctcct ttttgtatgg gcgctttacc 3272401 aaagtaaaga aaaaggagtt gggcttatgg tgactttaga cggttcttca ttgacaacag 3272461 ccgacgtcgc tcgtgtgctg tttgattttg aggaggcagc ggcttctgag gaaagtatgg 3272521 agcgcgtgaa aaaaagcaga gcagcagtgg aacggattgt acgcgacgaa aagacaatct 3272581 acggcatcaa caccggattt ggcaaattca gcgatgtcct gattcagaaa gaagactcgg 3272641 cggcgctgca gctgaattta atcctttctc atgcctgcgg agtcggcgac ccttttcctg 3272701 agtgtgtttc cagggcaatg ctgcttttgc gcgccaatgc gctgttaaaa ggcttttccg 3272761 gtgtacgcgc tgagctgatc gagcagttgc ttgctttttt aaataaacgc gtccatcctg 3272821 tcatccctca gcaaggatca cttggcgcaa gcggagatct ggcgccgctt tcccacttgg 3272881 cgcttgcgct gatcggacaa ggagaagtct tttttgaggg ggaaagaatg ccggcaatga 3272941 caggcttgaa aaaagcaggt attcaaccgg taacgctgac atccaaggaa gggcttgcct 3273001 tgattaacgg gactcaggcc atgactgcaa tgggggtggt cgcctacatc gaagctgaga 3273061 aactagccta tcaaacagaa cgaattgcca gcttaacgat tgaggggttg cagggaatta 3273121 tcgatgcatt tgacgaggat attcacttag cccgcggcta tcaggagcag atcgatgtcg 3273181 cagaacgaat tcgcttttat ctatctgaca gcggcctgac aacctcccag ggagaactgc 3273241 gggtacagga tgcctattca ttgcgctgta ttccgcaagt acacggtgcg acttggcaga 3273301 cactaggata tgtcaaagaa aaattagaga ttgaaatgaa cgcagctaca gacaatccac 3273361 tcattttcaa tgacggtgac aaagtgattt ccggcggaaa ctttcacgga cagccaatcg 3273421 cctttgccat ggattttctg aaaatcgcaa tatcagagct tgcgaatatc gcagagcgta 3273481 ggatcgaacg acttgtgaat ccgcagctga atgacctgcc gccgttcctg agccctcatc 3273541 ccggtctgca atccggtgca atgatcatgc agtacgccgc ggcctcactc gtttctgaaa 3273601 ataaaacact ggcccatcct gcaagtgtgg attccattcc gtcatccgcc aaccaagagg 3273661 accatgtcag catgggaacc atcgccgctc ggcatgctta tcaggtgatc gcaaatacaa 3273721 ggagagtcat tgcgatcgaa gccatttgcg cattgcaggc tgttgaatac agaggcatag 3273781 aacatgcagc gtcctatacg aaacagcttt ttcaagaaat gagaaaagtc gtgccgtcca 3273841 ttcagcagga ccgtgttttt tcctatgaca ttgaacgctt gactgactgg ctgaagaaag 3273901 aatctttaat acctgatcat cagaataaag aactaagggg gatgaacata tgactgatgt 3273961 aaaaaaatca atccgtgcca acagaggaac agagcttgaa tgcttaggat gggagcaaga 3274021 ggcagtgctt cggatgcttc gaaacaacct tgatccagaa gtcgccgaga agccggagga 3274081 cctcatcgta tatggcggga ttggcaaagc cgcacgggat tgggacgctt ttcacgccat 3274141 tgagcattcc ttgaaaacat taaaaaatga tgaaacattg ctcgtgcaat ccggaaagcc 3274201 cgttggcatg ttccgtacac acccgcaggc ccctcgcgtg ctcctagcaa attctgttct 3274261 tgttccgaag tgggcagact gggagcattt ccacgaactt gagaaaaaag ggttaatgat 3274321 gtacggacag atgacggctg gcagctggat ttacattggc tcacaaggca tattgcaagg 3274381 aacctatgaa accttcgctg agctggcgcg acagcacttc gggggcagct taaaaggaac 3274441 gttgacgctg acagcgggtc tcggcggaat gggaggcgcc cagccgctgt cagtcacgat 3274501 gaatgaaggc gtcgtgattg ccgtcgaggt tgacgagaaa cgcatcgaca agcggatcga 3274561 aacaaaatac tgcgatcgaa aaacagcatc gattgaggaa gccttagctt gggctgaaga 3274621 ggcaaagctg gcaggaaaac ctttgtccat tgcacttctc ggaaacgcag ctgaggtgca 3274681 tcacacactt ttgaaccgag gcgtcaaaat tgatattgtg acagatcaga catctgccca 3274741 tgacccttta atcggttatg ttcccgaggg ctattccctt gatgaagctg accgtttgcg 3274801 tcaagacact ccagagcttt acgtgcgcct tgcgaagcaa agcatgaaaa aacatgtcga 3274861 agccatgctg gcctttcagc aaaagggctc tattgtattt gactacggca acaatatccg 3274921 gcaagtcgca aaggatgaag ggctggagaa tgccttcgat tttccggggt ttgtccctgc 3274981 ctacatccgc cccttattct gtgaaggaaa agggccgttc cgctgggcgg cgctttccgg 3275041 agatccggca gatatttacc gtacggatgc gttattaaaa gagctgttcc cgacaaataa 3275101 agcccttcac cgctggattg atatggcaca ggaaaaagtc accttccaag gcttgccgtc 3275161 ccgtatctgc tggcttggat atggagaacg aaaaaagatg ggcctcgcca ttaacgagct 3275221 ggttagaacc ggggagctaa aagcgcctgt cgttattggg agagatcatt tggactgcgg 3275281 gtctgtcgcc tctccaaacc gggaaacaga agcgatgaag gatggaagtg acgctgtcgg 3275341 tgattgggct gtgctaaatg cgcttgtcaa cacggcggcg ggtgcaagct gggtttcctt 3275401 ccaccatggc ggcggcgtcg gaatgggcta ttcccttcat gccggcatgg ttgcagtggc 3275461 cgatggaagt gagctggctg acgagcggct cgcgcgggtc ttaacgagcg acccaggaat 3275521 gggcattatc cgtcatgcgg atgcgggtta tgaacgtgcc gttgaagtag cgaaggaaca 3275581 ggacattatc gtgccgatgc aaaaataaag gagtgatgac atgccaaagc aaattgatac 3275641 gattctcatc aacatcggtc agcttttgac gatggaaagc agcggtccgc gggcaggcaa 3275701 aagcatgcag gatcttcatg tgatcgaaga cgctgttgtc ggcatccatg aacagaaaat 3275761 tgtgttcgcc ggacaaaaag gggctgaagc cggttacgag gcagacgaaa tcattgactg 3275821 ttcgggacgc cttgtaacgc ctggcctcgt tgatccgcac acccatcttg tatttggcgg 3275881 atctcgtgaa aaggagatga accttaagct tcagggcatt tcatatttgg atattctggc 3275941 gcagggcggc gggattctgt ctacagtcaa ggataccagg gcggcttcag aagaagagct 3276001 gctgcaaaaa gcccattttc atctgcaaag aatgctgtcc tacggcacaa ccacagcaga 3276061 agtgaaaagc ggctacggct tggaaaaaga gacagagctc aaacagttgc gtgtcgcaaa 3276121 gaaactgcat gaaagccagc ctgttgacct tgtttccaca tttatgggag cccatgcgat 3276181 tcctcccgaa tatcaaaacg atccagatga ttttctggat caaatgcttt cccttttgcc 3276241 ggaaatcaaa gagcaggagc tcgccagctt tgctgatatt tttacagaaa caggcgtttt 3276301 tacagtcagc caatcccgcc gttatttaca aaaagcagct gaggcaggct tcggattaaa 3276361 aatacacgca gatgaaatcg atccgcttgg aggtgctgaa ttagcaggta agctaaaggc 3276421 cgtctcagcc gaccatttgg taggtacatc ggacgaaggc ataaagaaat tggctgaggc 3276481 aggaacgatc gccgtcctct tgccgggcac gacattttat cttggcaaaa gcacatacgc 3276541 cagggcaaga gctatgattg atgaaggtgt atgtgtcagc ttggcaacgg attttaatcc 3276601 tggcagctcg ccgactgaaa atatccagct gattatgtcc attgccgcgc ttcatctgaa 3276661 aatgactgca gaagaaatat ggcacgcggt cacagtcaat gccgcatatg ccataggaaa 3276721 aggagaagaa gccggtcagc tcaaagctgg ccgctcagct gatcttgtca tttggcaagc 3276781 cccgaactat atgtatattc cgtatcacta cggggtcaat catgtacatc aagtcatgaa 3276841 aaatggaaca attgttgtca acagggaggg agccattctt ggataagtac ccttttctca 3276901 gagaggccgg atcttcgttt aaagaccggg atgtcacaaa aatgagcgac ctgatcgcaa 3276961 catgggacgg ccaggacatt aagggaccgg cgttgatagg tgtcccccta tcaaaatcct 3277021 ccatcagtca ttcaggcgct tcctttgcac ccggaacaat acgccaggct ctgaaacatt 3277081 catcagccta ttctgctgag cttggagagc acgtcgtatc agagcttcta tatgacctgg 3277141 gggatatcga tattcatgtc actgatatcg taaagtcaca tcatcacatt ttccaaacca 3277201 tgcacgctct gctttcggat catccggatt gggtgccgct catacttggg ggagataact 3277261 ctatcagcta ctccacaata aaagcgatag cacaaacaaa aggaacgaca gcggtgattc 3277321 aatttgatgc ccatcacgat gttcgcaata cggaggacgg ggggccgaca aacggcaccc 3277381 ccttccgccg ccttttggat gaagagatca ttgaaggtca acatttgatc cagctgggta 3277441 tcagagaatt cagcaacagc caggcctatg aagcatatgc aaaaaaacat aacgtgaaca 3277501 ttcacacgat ggacatgatc cgggaaaaag gactaatccc aacgataaaa gagattttgc 3277561 ctgttgttca agataaaaca gatttcattt ttatatctgt tgacatggat gtcttagacc 3277621 agtcccatgc acccggctgt ccagcgattg gcccgggcgg cctctataca gacgaattgc 3277681 ttgaagcagt caagtacatc gcacaacagc ccaatgttgc cgggattgaa attgttgaag 3277741 tcgaccctac cctcgatttt cgagatatga caagcagagc tgcagctcat gttctgttac 3277801 acgcattaaa aggaatgaaa ctctccccat tcaagtgatc ttctggcagg ttgtattttg 3277861 ggtataagaa actcatctgc ctaaggaatg gcagctaaaa ggagggcgag acagtgaatc 3277921 ttcaggagaa cagcagccaa cagctaaaac gcacaatgaa aagcaggcac ctatttatga 3277981 tctcattggg aggcgtcata ggcacaggac ttttcctcag tacgggctat acgctacatc 3278041 aagccggacc cggcggtacg atactcgctt atgtaatcgg cgggttgatg atgtacctcg 3278101 tcatgcaatg tctcggcgaa ttgtcggttg ccatgccggt gaccggctct tttcaaaaat 3278161 atgctacaac atttatcggt ccatctaccg gttttatggt cggcatcatg tactggatca 3278221 attgggtggt gacggtaggc tctgagttta ccgcatccgg tattctcatg cagcgctggt 3278281 tccctgacag cagtgtatgg atgtggagtg cgatttttgc agcccttctt tttatatgca 3278341 acgcattttc agttaagtta tttgcggaaa ctgaattttg gttttccagc gtaaagattg 3278401 tcaccattat tttatttatc attttaggag gagccgccat gtttggcctg atctctttaa 3278461 acggaacggc ggatgctcct atgttgtcaa acttcacaga tcatggcggg ttgtttccaa 3278521 atggctttct cgccgttttt atcgcgatga tatctgtgag cttcgccttt tccggtacag 3278581 agttaatcgg cgttacagca ggagaatcag caaatcctca aaaggatata ccgcgatcca 3278641 tccgtaatgt cgcatggaga accgtgattt ttttcattgg cgctgtcttc atattatccg 3278701 ggttgatttc atggaaggac gcaggcgtga ttgaaagccc gtttgtcgcc gtatttgcgg 3278761 agatcggaat tccttacgct gctgatatta tgaatttcgt aatattaaca gccttgctgt 3278821 ctgtcgccaa ctcaggctta tatgcttcga cccgtatgat gtggtcttta gcaaatgaaa 3278881 acatgatcag ctcccgtttt aagaaagtga catctaaagg cattccttta aatgccttaa 3278941 tgatcagtat ggctgtatct tgtttatctc tcgtttccag tatcgtggcc cctggaactg 3279001 tctatgtggt gatggtcgca attgctggat ttgcaggagt cgtggtctgg atgagcattg 3279061 ccttgtccca actcttgttt cgaaagagat ttttgaaaaa agggggggat gtaaaagatc 3279121 tgacatttcg cacgccgctt tatcctctta tgcctatagc cgctctctta ttatgttctg 3279181 cttcttgtat cggtcttgct tttgatccca atcaaagaat cgcacttttc tgcggagttc 3279241 cttgtatcat cctttgctat ctcatctacc atttcaaaag aaatgttaca aaagcgaaaa 3279301 aaatcagcca agaggaatat ccagccgatc acatcctata attaaaaaag cacaccccgc 3279361 tcagcatggg atgtgcttta ttttttattc tgtaattaac gtatgaatca gcttcggcgc 3279421 cttcgcttcc gcggcgatgc ggatgttgtc atagactttt gcgatgactt catcgacgtt 3279481 ttctcggtta gcgtaaagcg ttacgagcgg ttcccctttt tctactttgt cgccgacctt 3279541 tttgcggagc atgatgccga cggctaaatc gatttcgtct tcttttgtgg cgcggccggc 3279601 acctaacagc atcgccgcga cgccgatttc gtccgcgacg atttcagaga cgacacccgc 3279661 ttctttggca ggcacatcaa tttgatatgc ggcttgcgga agcttagacg gatcgtcaac 3279721 aattgagctg tcgccgcctt ggtttttcag gaaatccttg aatttctcaa gtgctttgcc 3279781 gtttttcatg acttcttcca gcttcgctct cgcttcgtcc aatgtatcgg cttttttcgc 3279841 aagcacaacc atctggctgc cgagcgttaa gacaagctca tgaagatcct caggcccctc 3279901 gcctttgagc gtgtcgatcg cttctttgac ttcaagcgca tttccgatcg caaagccgag 3279961 tggctgggac atgtctgaaa tgacagccat tgtttgacgg ccgacgttat ttccgatgcg 3280021 taccatcgct ttggcaagtt cagctgcgtc ttcttctgtt ttcatgaagg cgcccgctcc 3280081 cgtttttacg tcaagcacga tggcgtccgc cccggcagcg atttttttgc tcataatcga 3280141 gcttgcaatg agcggaatgg aattgaccgt tcccgttaca tcacgaagcg cgtacagttt 3280201 tttatcagcc ggcgttaaat tgccgctttg gccgatgacc gcaaccttgt cgcggttcac 3280261 aagtttaata aattcatcct tcgtcagttc cacgtggaag cccatgattg cctctaactt 3280321 atcaatcgtg ccgcccgtat ggccgaggcc gcggccggac atcttagcaa ccggcacatc 3280381 aagagccgca acaagcggag cgagaacgag cgttgtcgtg tcgccgacgc cgccggtaga 3280441 gtgtttatcc actttaattc cttcaatggc agaaagatca atcgtttcac cggagttcac 3280501 catagccatc gtcaagtccg cgcgttcacg gtcactcata tcctggaaga aaatcgccat 3280561 agcaagcgcg cttgcctgat aatcaggaat gcttccatct gtatagccgt tcacaaaaaa 3280621 ttgaatttct tcagtggtga gttcttttcc gttttgtttt ttgatgatga tatctaccat 3280681 tctcatgttt ggtcaccgat ccttttcgat taagttcagt aaatcaagcc cacaattgct 3280741 gctgataaaa agctgacaag cgtagcaccg tataataatt tcaagccgaa acgagcgacg 3280801 acatttcctt gcttttcatt cagtcctttt acggcaccgg caatgattcc gattgaggag 3280861 aagttcgcaa atgacacaag gaataccgat acgatcgctg ttgtacggcc gctgaaatgg 3280921 aaaccgtttt gcgtaagcga cgtcatggcg acaaattcat tcgataccat ttttgttgcc 3280981 ataatgcttc ccgcattaac agcttcattc catgggatac cgacaagaaa agcgaatgga 3281041 gcaaacacat atccaagaat gccttggaac gaaataccga atactgcatt aaaaatgcca 3281101 ttgatcaatg caataatcgc gacaaatcca atcagcatcg cagcgacgac aaccgctact 3281161 ttgaaaccgt caagaatgta ttctccgagc acttcgaaga aggattgttt ttcttcttcc 3281221 tcaacacgaa gcatatcctc ttcttttgca acctcgtacg gattgataat agaagcgata 3281281 atgaaaccgc caaataagtt caaaacaagc gctgttacaa catattccgg tttcagcatt 3281341 gtcatatacg caccgacaat cgacattgat acagttgaca tcgcagatgc gcaaagcgtg 3281401 tacaagcgct gctgatttaa aagaccgagt tctttcttca aggagataaa tacttctgac 3281461 tgccctaaaa tcgcagaagc cactgcgtta tacgattcca atcttcccat accgtttacc 3281521 ttgctgaggg caaggccgat atatctaatg ataaacggga ggactttcca cttttgcaga 3281581 atcccgatca gagcggaaat aaacacgatt ggcaagagaa cattcataaa gaatgtcgtt 3281641 tggtccgcat tcaccaagcc gccaaacaca aagttaattc cctctgccgc gtattcaagc 3281701 aggtaaccga atccttttgc aaatcctccc acgaggaaat tccctattcc ggtattgagg 3281761 agaatgtagc caagaataaa ttgcaaaatg agcataacaa caattgggcg gatcttaatt 3281821 ctttttttgc cgctgctcgc gatccacgcg aggcctaaaa acacgattaa accgataatc 3281881 ccaatcaaat acttcatatg tgtttctcct ttatttgtat tcgcttacaa ttactgtttc 3281941 ctcagaaaac ggaaagcagt ctgccttccg tcagctctta atagttgtct ccgcctgatg 3282001 cattttctcc ttttacgata gaaacgcctg cgctggcgcc aattcggctt gctccggcct 3282061 ctaccattgt gtctacatct tctttcgttc tgacgccgcc agatgctttc acgccgatat 3282121 caggccctac tgttttgcgc attaaggcga tatcttcctt cgttgcgccg cctgtagaaa 3282181 agcctgttga tgtttttacg aaatccgctc ccgcagacac cgctaaacgg catgcacgtt 3282241 ctttttcttc atcagtcaga aggcacgttt cgataatgac tttgacaagc gcttttccgg 3282301 ctacagcttc cactacaccg cggatatcag cttccaccac atcgtcttcc ttgtctttta 3282361 aagcggcaat attaatgacc atatccactt cagtggcgcc ttttgaaatg gcgtcttttg 3282421 tttcgaacgc ttttgtttca gttgtattgg caccgagcgg gaagccgatg accgtacaaa 3282481 cgtcgactcc agttccctta agctcttttg cagcaagctc cacccatgtc ggattgacac 3282541 atactgaagc aaatttgtat gttttcgctt cttcaattag ttttagaatg tccgcttttt 3282601 gtgtatgcgg tttcaaagct gtatgatcaa ttatgttggc taatgacatc cttcgcacac 3282661 ttcctttttt gttaagatat tttttagcat aaccgacttt tgaacatatg taaattggta 3282721 attgaaattt tgttcaatga aaggtttgaa cgtgtcacaa atcattaaca agcgccctcg 3282781 cggtatgctg gtcaatgatt aaaacgttgg catattttcc ggttaatgct ccgtgaatgg 3282841 aagatacttt tctgcttccg ccggcaacta aaatggagcg ttccttcagt ctaaggtctt 3282901 gaagctcaac accgatggtc cggtcattga tggcgctgct gcaaatattc cctttcgcat 3282961 caaaaaagcg tgaacaaata tccccgacgg cctgtttttt cagcagggct ttctcttctt 3283021 cgttaaaata tccgagccga aacaacagcg cttcatcacg gacagtcccg accgtaaaga 3283081 gagcgatatt cgcctgcttg cccatctcaa tgatccgttc aatatgacgg tctttctcca 3283141 ccattcgctt cacatccgca ttatcaaaca cgacgggaag cgggagatag cgcggcatcg 3283201 tttgaaaagc ctctgcaaac agctgaatcg tttcagccga atacgtgttt acccgggaat 3283261 ggctgatgcc gcctttcagc tggacgacct cgacgccttt tacctgcttc ggctgcatgt 3283321 tttgcgcgat ttgatacatg gtggttcccc agctgacgcc gacaatgtcg ccgtctttta 3283381 ccgtttcatg catatattct gcaccatagc ggcttaggtc atgtgtaatt cctgcataat 3283441 cgggtgtcgg ggaaaacaca acatgcgcct caaggagccc gtatttctct tcaagtatgg 3283501 aaccgagcgc atccaaatcc tcaaaagggt ccatgacgcg aatctggaca tacccttttt 3283561 cctttgcata ttgcagcagc cgggaaacgg ttggccttga aatgttgagc tgctcagcaa 3283621 tttgctgctg actgtagtca gactgatagt aaagccttgc cgcttctatg cttaattgct 3283681 gtttttcccg atccattctg cacctccctg tggatcagtc ctgataaaac tgcttttgat 3283741 ttgcttttat tatacaggct ggcgccggct ttcatccacc tgatttctaa gaaactgaaa 3283801 aacgctctgg gcgcggacct gcccagagct tacttctccc aagtcggttt ctctgagcat 3283861 aaagttattt cgtttttcct aaactcagcg gatctgtgat catctctttt ggctataaag 3283921 tttccgtttt ttcaaaacaa atgtttcaaa tgagatagga aatgggtact aatctattaa 3283981 ctttgttaca tatttttaga tactcattgg ctcaacaact gaggaggaga catttgtgaa 3284041 gaaagacaca aggaaatata tgatctactt tttcggcgct ttagggggac tgctatatgg 3284101 ttacgataca ggtgttatct ccggagcact cctgtttatc aataacgata ttcctttaac 3284161 gacattgaca gaaggattgg ttgtcagcat gctgctcctt ggcgcgattt tcggttctgc 3284221 cttgagcggc acatgctcag accgctgggg caggagaaag gttgtatttg tcctttccat 3284281 catttttatt atcggtgcgc tcgcttgcgc attttctcaa acaatcggca tgctgattgc 3284341 atctagggtg atactcgggt tggccgtcgg cggttcaacg gcacttgtgc ccgtgtatct 3284401 ttccgaaatg gcaccgacga aaattcgcgg gacactcggc acaatgaaca acttaatgat 3284461 tgtcaccggg attttgctcg cctatatcgt taactacctg ttcacaccgt ttgaagcgtg 3284521 gcgctggatg gtcggtctgg ctgcagtgcc tgccgtgctt ctattaatcg gcatcgcctt 3284581 catgccggaa tcgccaagat ggctcgtgaa gcgcggcagc gaagaagaag cgagacgcat 3284641 catgaacatc actcatgacc ccaaagacat cgaaatggaa ttggcagaga tgaagcaagg 3284701 ggaagcggag aaaaaagaaa cgacacttgg cgtgctgaaa gccaagtgga ttcgccctat 3284761 gcttctgatt ggcgtcggcc ttgccatttt ccagcaggca gtcggcatta acacggtcat 3284821 ctactacgcg ccaaccattt ttacgaaggc cggtcttggc acatcagctt cggcgctcgg 3284881 cacaatggga atcggcatcc tcaacgtcat catgtgtatc actgccatga tcttaattga 3284941 ccgtgtcggc cgcaaaaaac ttctgatctg gggaagtgtc ggcatcacac tgagccttgc 3285001 tgctttatca ggcgtgctcc tgacactggg gctttccgca tcaacagcgt ggatgacagt 3285061 agtctttctc ggtgtctata tcgtctttta ccaggcgaca tggggtccgg tagtgtgggt 3285121 gctcatgcct gagctcttcc cgtccaaagc acgcggagcc gcgacagggt tcacgacttt 3285181 ggtgttatcg gcggctaacc tgatcgtgtc gcttgtcttc ccgctgatgc taagcgcgat 3285241 gggcatcgca tgggtcttta tggttttctc agtcatttgt cttctctcat ttttcttcgc 3285301 gttctacatg gtaccggaaa ccaaagggaa aagcttggag gaaattgaag caagcctgaa 3285361 aaaacggttt aaaaagaaga aaagcaccca aaaccaagtg ctgaatgagc gtacattata 3285421 aaaaaaggaa tcgtctcctt atgagacgat tcctttttct gtttacacca tgaccttgca 3285481 aatattgttc gtaaattcca cagggtcctg aatcggcagg ccttcgatga ggagcgcctg 3285541 attgtacaga aggtttgtgt acaggctcag cttctcttta tcttgttcaa acgcgtcctg 3285601 cagtgtttgg aatacctcgt gatttgggtt gatttccagc actttttccg ccttcacatt 3285661 ttggctgtca ggcatcgcat ttaagatttt ttccatctca attgtcactt cgccgtcagc 3285721 agcaaggcag actggatgtg atttaagccg ttttgagatt ctgacgtttt tcactttgtc 3285781 tgacagaatg tttttcattt cctcaaacag atccttatac ttgctttcct cttcctcgga 3285841 ctgcttttga tcctcatccg tgtctatgcc aaggtctccg cttgatacgg acttgaattc 3285901 tttttcctga taagaagcca gcattttaat tgcaaactca tcgatgtcct cagtaaagta 3285961 gaggatttca tagcctttgt ccgccaccat ttccgtttgc ggcagtttct caatgcggtc 3286021 gtaagaatca ccggtcgcgt aataaatgaa tttctgctcc tctggcattc tggaaacata 3286081 ctcgtctaag ctgaccagtt ttttctcttt tgaagagtag aataagagga gatccttcaa 3286141 ttgatcctta ttcgcgccaa aatcattgta cacgccgaat ttcagctgtc tgccgaacga 3286201 cttgtagaac gtctcgtatt tctcgcggtc ttttttcaac aggctttgca gctcgctttt 3286261 gattttcttg ctgatgtttt tcgcgatcag cttcagctgg cggtcatgct gcagcatttc 3286321 tctggaaata ttcagcgaca gatcctcaga atcgaccatg cccttcacaa agctgaagtg 3286381 gtccggtagc aggtctgcgc acttattcat gatcagcacg ccattggaat acagctccaa 3286441 gcctttctca tattccttgg aatagtagtc aaacggcatg ttttcaggga cgaatagaat 3286501 cgcgttgtag cgaaccgctc catccacgct gatatgaacg tgtgtcagcg gtttatcaaa 3286561 cccgtaatgc ttttcagcat agaatttttc ataatcctca tctgtcagct cgcttttgtt 3286621 ttttctccag atcggcacca tgctgttgac cgtctgctct tcctgcacct cttcaaattc 3286681 attttcgctg ccttccttcg gcttattaat ggttgtatcc attttgatcg ggtagcgaat 3286741 gaagtcggag tacttcttga tgatcgcttt taaacgatat tcctctaaaa actcgtcata 3286801 gctgtcatct tctgtgttct ctttgatttt caggataatg tctgtaccga cagaatcctt 3286861 ttcacacggc tcaatcgtat agccgtctgc acccgcagac tcccatttat aagcctcttc 3286921 gctgccaagc gctttactga tgactgtcac gacatcggca accataaatg ccgcgtaaaa 3286981 accgacaccg aactgcccga taatgtcatg tccgtctttc agctcgtttt cctttttaaa 3287041 cgcgagggaa ccgctttttg caattgttcc aagatgctgt tcaagctcat cctttgtcat 3287101 tccgatcccc gtatcagaga tggttaatgt tctcgcatct ttgtcagctg cgacctttat 3287161 gtagtaactg tctttatcaa acgtaagcgc atcgtccgta agcgctttgt aatagatttt 3287221 gtcaatcgca tcactcgaat tggagattaa ctcgcgcagg aaaatttctt tttgggtata 3287281 aatggagtta atcatcatat ccagcaagcg tttagactct gctttaaact cttttttcgc 3287341 cactcttgat cgctccttta ccattatgta aacccttttc agcatctatt tatcacataa 3287401 gatgacaatt gtcaattaga ttgatagatg catatatatg taaatttaac attagttgga 3287461 tttgttttca ctctttttct cactcattct cataaaaaag agaggcttca tcatcctctc 3287521 tttttttctg tgtcattcca acggccaaac tcccgcttca tccatatatg caccgggtag 3287581 aaaaacaaac cgaacggtat caaaaacaaa agattatgcc atgaagcatt cagaaatgcg 3287641 cttgcagtca ccgggaacgt aatctcttgc aataaaaaag agatgacagt cagcacaaca 3287701 aatgcagatg gaatggtcac gatgcaataa aacttgagct ccttcttatg ctgtaccttc 3287761 aaacatacaa acctcccaac aatttctaat tcatcttaac atatgctggc ctttcttttc 3287821 tcgcatgttt atcactgcac atagcgggaa gacaaataga aaaaggaggt ctcgtatcat 3287881 gggaagactt gaaaacaaaa cagcagttat cacaggcgcc gcgacaggca ttggtcaagc 3287941 gacggcggag gtttttgcca atgaaggcgc gcgtgtgatc atcggagata tcaataaaga 3288001 tcaaatggaa gaaacagttg acgcaatcag aaaaaacgga ggacaggccg aatcctttca 3288061 cctcgatgtg tcagatgaaa acagtgtgaa agcatttgct gatcaaatca aggatgcatg 3288121 cggaacgatt gatattctgt ttaataatgc cggcgttgat caggaaggcg gaaaggtgca 3288181 cgaatatccg gttgacctgt ttgaccgcat tatcgccgtc gacctgcgcg gcacattcct 3288241 ttgcagcaaa tatttgattc cgctcatgct cgaaaatgga ggctccatca tcaacacctc 3288301 ctccatgtca ggccgtgccg cggaccttga ccgctccggc tacaacgccg caaaaggcgg 3288361 tatcaccaac ctgacaaagg caatggcaat cgactacgca cgaaacggca tccgcgtcaa 3288421 ttccatttca ccgggcacga tcgaaacacc gctgattgac aaattagcag gcacaaaaga 3288481 acaggaaatg ggcgaacaat tccgcgaagc caacaaatgg atcacgccgc tcggacgtct 3288541 tggccagccc aaagaaatgg caacagtggc actgttcctc gcatcagacg acagctcata 3288601 cgtcacagga gaagacatca ccgcagacgg cggcatcatg gcgtacacat ggcctgggaa 3288661 gatgctgatt gaggagaaat ggaaggaaga aacgaaataa gagagggagc cccctctctt 3288721 tttgtctttt aaagcaatac aaccttatat ttcttcacat ccaaaaactg caaaaactcc 3288781 ctcgccagca cttcaggcgg atgcgccttt ccttcatcca gccgatacaa aagcaacccg 3288841 ataatcattg cggatacata atgggcataa agctttttct ctgcgtgaat atcagtttgc 3288901 tgatgcagat aaaacgattc cagcgctttg aacatatcag gtatcacatg aggaacaccc 3288961 cattcccgat tgagaaaatg gacaatgggc atgtttgaca aagcagaaag cagaatggcg 3289021 agcgccttct ccgcttcctt taaggaaaat tcattcgggc tggaggcaat cgtcaggtga 3289081 tcaatgatct ccgcacatga tcgctgtatc atggtttgga gcaattcctc cttattggca 3289141 tagtgatcat aaaaggttgc acggcggata ttgcttttac gcgtaatatc tgaaatcgtg 3289201 atgcccgcgt agtcttgttt ctccgccaat acatccagaa atgccttctg cagcgcctct 3289261 ctcgttcgaa ccacccgcct gtcgatttgc ttctccttct ctcgctctcc tggcacagct 3289321 tttccaaaca gccaataaaa ccgcttttga gaaacaagct cccatacctt ctggctgatg 3289381 gcttcaggag acgcggccgc atcctcattc agccaataca ggataatcgc gtacgtgtac 3289441 aaggcccgat aatgtccata aatgtcccgt tcaatcggcg ttaaattcac atggatcgga 3289501 gccagcagca catcctgctg aaacacatcc ttaaaaaaac gatgaaaatg tcctctgttc 3289561 atcatcacag aaaaaaagga acgatgctca tgaacaaagg acagcgtcgg atgcaccgtt 3289621 tgccgttttt tgttcaaatg aagggtatcc atatgactga aggcgtcaaa aagcgctttg 3289681 cccagtcctt ccttcatgtc ttcgatcaca tcctcaatga ttgaaaactt atcctcataa 3289741 taaaggtaga gcgatccgcg gctcactttg gccttctcag cgatttcttt cattgtgatg 3289801 tgttgaatat ctctatcttt caataaagcc agcagcgcct ctttcacttg agcttcggca 3289861 gattccggca caaaagacac ctccaatcat tagacagatc ttagatatat gtacggtaac 3289921 gtatagatgg ttcaccgttg tctttcttac agaaaaggta ccaccttata ataggtccga 3289981 gaaaagaaga aagcaaatga gggggatttt acaatggaac agcaagtaaa ggacgacatc 3290041 cagcgtgtct ttcagcttca gaaaaaacag caaaaagcct tgcgcgcttc aacagcggaa 3290101 cagcggagag aaaagcttca acgcttttta gattccgtca tcgcccatga agaagaaatc 3290161 atcgaagcga tccgcaaaga cgtccgcaaa ccatatcacg aagtcaaaaa agcggaaatc 3290221 gaaggaacaa aaaaagcgat tagagataat atgaataacc tggaacaatg gatggcgcct 3290281 aaagaagtcg gttcatcgtt aagccctgac gcaaacggaa ttcttatgta cgagcctaaa 3290341 ggcgtcacac tcatcctcgg cccgtggaac tatccgttta tgctgacgat ggcgccgctt 3290401 gccgcttctc tcgcagccgg aaacagcgcg attgtgaagc tgtccgattt cacgatgaac 3290461 acgagcaaca ttgctgctaa agtaataaga gacgcttttg atgaaaaaga agtcgcgatt 3290521 tttgaaggag aggttgaggt ggcaaccgaa ctacttgatc agccgttcga ccatattttc 3290581 ttcactggaa gcacaaatgt cgggaaaatt gtcatgacag cggctgccaa acacttggca 3290641 tctgtcacac ttgagcttgg cggcaagagc ccgacgatca ttgacagtga atacgatctg 3290701 atggacgcag cgaaaaagat cgccgtcggg aaattcgtaa acgccggcca aacctgcatc 3290761 gcacctgatt acctgttcat taaaaaagac gttcaggaca ggttcgcggg gattttacaa 3290821 acagtcgtca acgctggatt tatggaggat gatcataccc cagaccgcag caaatttacg 3290881 cagatcgtca atgaccgcaa cttcaaccgc gtcaaagatc tgttcgacga tgccatcgaa 3290941 agaggggcgg aagtggtgtt cggcggcgta ttcgatgcca gcgaccgcac gatctcgcca 3291001 accgttttga aaaacgtcac gcctgacatg aaaatcatgc aggaggaaat cttcgcatcg 3291061 atcctgccaa tgatgaacta tgaagacatc gacgaggtca tcgattacgt aaatgaccgc 3291121 gataaaccgc ttgcacttta tgtgttcagc aaaaaccaag atctgattga caacgtcctt 3291181 cagcacacga catcaggaaa tgccgccatc aatgatgtcg tcgtccattt cagtgacgtc 3291241 aacctgccat tcggcggcgt caacacaagc ggaatcggct cctatcatgg ggtatacgga 3291301 ttcaaagagt tttctcatga gaagggtgta tttattcagg ccgctgaata atcgcatgat 3291361 caaaaggcgc ttccttagag gagcgccttt tattgtaact ccttgaccaa aagcaattca 3291421 tcacggatag gtattttatt atctgccagt aaaggaattt cgggcttcat ctttctggcc 3291481 gtctcgactg cattcacaaa tagtcgatcc aaccggtacc ctctcttctg ataaaacgct 3291541 aatgcatgaa tattatcatt ggttgtgatc agttttattt gtttgatatt tctctctctg 3291601 catgcttcct cggctttctc tagcagagct gttccgatcc ctttattctc aatgacacta 3291661 tccagcgaaa tgatttcaca ggcatcttct tcaaatatgt atgtaataag gccaacaatc 3291721 tggttatcat cgttgagcat tccataacca tctaattcat cgcagttata aataccgcta 3291781 gaaataacca tttgcggact gccccagtgt ttttgaaaaa acgcggaaac aagatcttta 3291841 ggtacctggc atgtcggaat aatattcata ttttcctcct tttagctgaa caaaaataag 3291901 agaattaaca acctatttta tgtcattaat ccccttatct agtatttact agaacttata 3291961 acttgtcaaa agctgtctga ataccaattg cgtggattga taaggatcaa aatctgaatc 3292021 ctgagattgg aagatttgct ctggggtcaa tgtctctgcg ttctctgata acgtttgaat 3292081 cagactttcc aaatatccat ttaactctga tttggacgat tcatgtaggg attgatgatt 3292141 tacagcgagt tctctaaatc tgttatcact gattaatttt tttcgaagag ctgctagcat 3292201 caagtcaagc catgcaggct ggccaaatgt aatatttaaa gctaacgttg cttgatcaga 3292261 tttggtggag tgccataaac ctcttggcaa atacagcatg gttcccggtg ttaaattaac 3292321 gatttctgca tctggcagat cctcttttgg cggatctcct ttccaatatg actgtaaatc 3292381 atcaggatag taaggagcct ctgataaatc atagtgctgc attggattgc tcacattttc 3292441 attcttggca agcttccatg ttttctcacc ttgaatttga aaaatcaagt tggtgtaggc 3292501 gtcaaaatgg gctttgaatc ccccgccatt tttcgccgcg taaacaatgg ctttggaaga 3292561 agtacccgca ggcagtctta attccgcttt gagtttttct atccaccttc tgacttgggg 3292621 aataaatagg tcggtgaaat caaactctaa tgcagcccct ttttcatacc actctaaagc 3292681 ctctgcaggt gacacaagaa atctgtctgt gatcccttca gattcttcaa tcacagcatc 3292741 accaacgacc atgactggat tattgtagat agccaatacg ttttctagcg ttctaacctt 3292801 ttcaaacccc ggtatgcttg taaatctctc cacttctcct ctggctacca aaggttttac 3292861 aggccaatat tcttctaaaa actcactcat cgttacagga ctgatgatag actccaaaac 3292921 cgattcggtt acagcactca tattatccct cccaaaaaaa gtaacttcac cacaaagata 3292981 taacattttt ttctaaaagt aaatattgac agaattatca gaggattata atatttagtt 3293041 gtgcgtgata gcctattttt ttacaaggaa ggagggaaaa ggatgaaaaa ggcttataag 3293101 aaacctcgtc tttttgaact gcgccgtgct gtagcagctg gcggccatta atctcatata 3293161 gcatttgaca tctagtactc tattttagga gggatgctca atgaaaaaag cttataagaa 3293221 acctcgcctt tttgaactgc gccgtgctgt agcagctggc ggccattaat ctcatatagc 3293281 atttgacatc tagtactcta ttttaggagg gatgctcaat gaaaaaagct tataagaaac 3293341 ctcgcctttt tgaattgcgc cgcgctgtag cagctggcgg tcattaatct tatccaaaac 3293401 gattaacgtt tgaggctatc acgccaactt gataaggagg atgctgaaga tgattacggc 3293461 tgaagaatgc agaacgtaca aagaatttgt tgatctttac caatcctatc tttacccctt 3293521 gcttggcgcc agactgtccc ggatgtattc ccccaaaaac aaagtcatta tcgatatggg 3293581 cacaggtcca ggttatttaa gcattcagtt ggctaaaaga acaaatgcgc acgtgcatgc 3293641 tgtcgatatt aacccggcca tgcatgaaat cgctcaagaa gaagctaaaa aaagcggagt 3293701 aagcagcctg atttcatttg atttggaaga tgtccaccat ttatcttacg ctgaccaata 3293761 tgctgacttc atcgtctcct actcttgcct gcatcattgg gaagacgttg ttaaaggact 3293821 taaagagtgc tatagagttc tggctccggg cggaaaaatt gtcattttgg atacatttaa 3293881 tccccaagga agccatttag agattatgcg aaaacaaatc aaagaaccgg aatacttcag 3293941 gtttgtaaga gaggcatttg aagaaagtta ttcctttgaa gacattcacc agtttgttca 3294001 ggatgccggc attcccaatt attcattaga aacctttcac tttttaccgg aggattttat 3294061 agaaagctta gatgagctgg aggatgctcc cctgtgggaa caaaatgatc aaagtactga 3294121 tcatgaaatt gagtctgtca catggatgtt aacgatagaa aaagaaaagg aaggtgcatt 3294181 gtaatgatca atgaatcaac tgttttatcc aaaaatccag aaatgccatc aagaaaatat 3294241 ttgaaaagca ttattataga gccgggcatc actttaaatg aaatggcatc agatatttat 3294301 aaccatatcg acggcaaggt cagcatacat gatatttgct caaaaatcgt caatgaatat 3294361 gatgttgatt atcaaacctg cttagaagat tgtatggagc tgtttgagtt gcttattgat 3294421 catgaagcaa tcaaagttaa gcagggggca tgagaattgg aaaaacaaaa agtgcttgct 3294481 ttaccagacg atgtacatga gctgagtaca caccgttcta aatcaatcgt aaattacatc 3294541 atcactctgc ttgcctttgc caaaaaacaa ggattgactc atcaagatat tgtaagctgg 3294601 attcacgagc aatatgagga aagaggatat tatgatgagt ggagacacat taacagccaa 3294661 caaccagttg gatcatttgt ggaactcttt ataaaaggaa gacgtttact ttatgacaaa 3294721 attgaattgt ttgaaacaga agataaatat gtcgtaaata cccacacttg gtatgaaaaa 3294781 gaacctagtg aggccttttt ttattttgaa attgatcccg aagaattttc tgcgtacgct 3294841 tccattctcg caatcgaaaa cgcaaaacgt ctcggaatta aaatcgatat tgtaaaagaa 3294901 acagatgtag agacagctta tatctataaa catcaataac gctattggga gggagacata 3294961 tgtgcgggct cgcgggtatt ataaatctgg ctgctccccg ttctcaggaa tgtacctttc 3295021 atatattgaa aggcatggca gatgccatca gctatagggg accggatgat gaacaatatc 3295081 atattgattc caaagtcggc tttgcatttc ggcgattgtc cattcttgac cttgtaaatg 3295141 gacagcagcc ctttttaaat gaggatggat caatcgtcgt tatggtaaat ggagaaattt 3295201 ataactataa agaactgaag gcttctttac acaatcatat gtttaaaacg acatctgatt 3295261 gtgaagtaat tgttcattta tatgaagaaa aagggattgg atttgtagac gacatcatcg 3295321 gaatgttttc aatagccatt tgggacaaaa ataaaaacaa agtattttta gttcgtgacc 3295381 gctttgggat taaaccgctt ttttacacag agctaaaaca cgagcttata tttgcctctg 3295441 aaataaaatc cctattttct catcctcact gtccccgcca atttaattgg aaagaagcac 3295501 tctcagacat ttggctaagc ggggaagcag ccagtaatca taaagaaacc acttcctttt 3295561 ttgtaaacat ccaaaatctc gatgctggcc attatctcga aattaatttg acaacaaatg 3295621 aacgaaaaac agcaagctat tggtctttac aggatatttt gctcaggcaa ggctatcgtg 3295681 agaatctcca tcccgatgac ctgattgaag gatatagaga actgctggca gattcagtcc 3295741 atagatgttt acaaagcgac gttgaagtcg ggttgtttct tagcggtggc attgattcag 3295801 ctgcagtcgc acattttgct gcagaaaaac aggatctcca tacgtttaca gtattaagcc 3295861 aaagtacatt tacaaatgaa gatgcaaaat atgcccattg gctggctaaa gatttacacc 3295921 ttccaaatca tcaggttctc tatcaattag ggaacgatga gttattacaa ccagagtcat 3295981 ataaacattt gttatggatc tgtgaaacac cgttttgcgg accggaacaa ttatataagt 3296041 ttcatttaca taagtatgcc aaagcgataa ggccaaacct gaaagtcatg ctgaccggcc 3296101 agggcagcga cgaatttaac ggcggttaca gcacgacact ttcaccagcc gagaacccaa 3296161 gttgggaagg atttattgaa tcggtcaata cgatggagat gaaccggctg catcggctgc 3296221 agggaaatat ctttagagtg tgggaggagc attttggact ttctcctata aacctttctt 3296281 atttaaagag caatgattcc agccaagcag atccttggca atcgtatgtc ctgacaaaat 3296341 accgtgatct gcaaatgtat aattgctggc atgaagatcg gatcgccgcg gctaatcata 3296401 tcgaaaaccg tgtaccgttc ttggaccatc ggcttgttga atgggtttgc ggaatacctg 3296461 atggactccg taaagacttg ttatgggata agtcggtatt gcgaaaatca ttaacaaatg 3296521 agctgcatac aagctatacc caccggccaa aggttccttt tttctatggt aaggacgtga 3296581 gatatacaca taaaatgatg tttcatcttc tgaagaaaaa caattatcag cttatagagg 3296641 aggccttctc tcacagcgat gcctccagca taatacaggt tgaacacatt catgccatca 3296701 tgacatattt ggaggatgat cctgagttta caaattttga atttttatta agactggtga 3296761 acatgggact tttatcaaaa atgactaaag aaaccccttc tgttcaatta gacataacca 3296821 gccatttaga atcgataaca ataaaagact ggcactcaca ggaaggtgat attgccagtc 3296881 gtttaaatat ctcagccaat aagtgtgaag gacaagatat tttggcgcta aaccctggcg 3296941 tcactctgtt aaggccggaa agcgatagtg agcattgcat ctacattgcg gaagaaggat 3297001 ttattcagtt tattgtttcg gaggaagacg tcggagcttg gctgcatatt ctctgcgata 3297061 ttaatggaaa agacacactt catacgattt tagacagaca tggtgtcagc cttgaagaag 3297121 tggccaaata tattcaagaa gccatcgaac acaatatcat tttgatcaaa caaaaaaatc 3297181 tgccagaagg agcatataga tgagcatctt ttattcgttt tccgcactta ggggattagc 3297241 aatggggatt ttttcgccta tttggattct ttatctgata tctaaagatt atgatttcct 3297301 tcagattgga ttaatgggag cggtacttga aattgctaag cttatatttg aagttccttc 3297361 cggcgttttt gctgatcgtt atggaattaa aatttcaatt gccagttcat tctttttctc 3297421 catccttaca tgggccttct tcccttttat cgattcagct gctatttgca tactggctat 3297481 gatcatatgg gctttatcag attccttaat ttccggttct tttgaaactt ggatgagccg 3297541 tgtcgcaggg gaagatcgat tcggcaaaga aatgatgaaa aacacacaat tgctaatcac 3297601 ttttttaatt attggaagta ttgccagcgg gtatttgtat tcattaaata tctattttcc 3297661 tttcctgctc gttatggtga tctacttatt actatttatt tggatgtctg tatttattaa 3297721 agtcccttct gtttccgaaa caaatcatgg ggatcagaac caacatgatt cgataaagat 3297781 tatcaaagaa agtttaaaaa ttatctttaa caaaaaaagg gttcttttaa tcgtcatagc 3297841 cggtttcttt acagccacag cctatgacac aatttcccgt tactggcagc cttttttgag 3297901 tgatttaggc ttttcagaaa agtcactggg atatattttt gccctaggag ggtttaccgc 3297961 tctcgttctt ttgacattaa ccatcaggtt cgaaaagaag atcgaaaaaa atccatatct 3298021 cgctttaacc tcattggatt ccatgggcat ggtcatgact tttctattgt ctagagcatt 3298081 caggccgctg ggcattccat gtacagcgtt tttgcttgca attgaagata ttcatcatcc 3298141 gatcgtaaca agttacttaa ataagttttt ccccgattca tacaagaaca cacttttctc 3298201 gttaaactca ggggtaggag caattggaga aattctttcc ggtgtcattt tcggcatcat 3298261 ttccgcagcc tttgggctct ctgccatgtt tgttgttgta gctgtatttc tattaatccc 3298321 tattatcctt tatacgatag tgcctaagat taaagacaat gatatgaaag ttcagattga 3298381 aaaatcccag caagtgtaaa tgttttgtat cacagtaaga agaccttctt attaaaagaa 3298441 ggtcttctgc tattctattc agttatttcc caaaagccat cagcttcgta taacttccaa 3298501 tataaagtgt tccgtcctca gcgagctgag gagaagacac gacgttgctg tcggtttgat 3298561 agctccataa ttcattgccg tttgcgtctg ccgcataaac cttcatatca tctgacccga 3298621 aataaaccgt tcccttcgcg tcaatcagcg gcgccgttct gacagggccg tctgtgtaga 3298681 atgaccagtt catatccccg tttttgctga tggaaaacag ctcgccgctt cctgagccga 3298741 tgtagatatt gccattatga tcaatcgcag gagatgagct ggagaacccg tttagcggga 3298801 atgtccattt caaactgcct gttgatgtat aagcatacag ctgtccatct tggttgccgg 3298861 cataaatgtt tccgtcctta tcaatcaccg gatatccttt aaacgcattt gacgtcgttc 3298921 tggaccattt cacctgtccg gttccggagt tgatcgcata aaacacgtaa ttatatgtgc 3298981 cgacatacac ggtgccgttt ttggcaagca ccggcacaga gctgacgacc ccatttgttt 3299041 tcaacttcca gcgctctgtc caggttgatt ttgacgtcgg tttgatcgcg tgaacataat 3299101 tatcaagtgt tgagaaatac aacgtcccgt ctgaaccgat caccgtttca gagcttggcc 3299161 cgccgcttaa cggaaccgtt gttaaaattt ctcccgtttc tttgtcaata aaataaatct 3299221 ttttgtcata ggatgccaaa tagataacgc cgttggtccc aagtacagga gattgcgtat 3299281 atgtttttcc aagattgccc gtcacccatt tgactgagcc gtctggatta aaggctttca 3299341 tttccccgtc tctggaatga agatatactg tgccgtctcc gtcaatcaca gcccccgctc 3299401 cattttgcgg agtcgttctg atgtcgtttt gccatttcag cgtcccgtct gtatttccgg 3299461 cgaaccggct ttcgcgtgac cagttaaaca tggcaggcgc catcgcttgt acatcatatc 3299521 ttcctggcaa aaagccagat gctccattat tttgagaaaa caccgtttcc gccgcataag 3299581 cagctgtcgg ctgaagcact ttggcagcgg gcacatcaga aacagcgccg gccgaaacag 3299641 ccgccgccac cgcagctccc gcaatcaaag ctttcatacg aaatgacttg accatcattg 3299701 agacccccat tatatgtaac ttctaatttg tgaccatcat aacatattca tccattttat 3299761 aaatctattt cacaaaaaca tcacaaacta gaaaactatg taagagtatt cacggacgtt 3299821 ttttcagcac ccgatcgaaa tgcagccaca aaccaaatga cgttgacagc agccgcagcg 3299881 agactaactc ccaaaacaaa gatcacctca gaaagcagat ggtcactaaa gaaactaaac 3299941 atcaagataa aaccggccga agacaaatga atcaaaagcc cgaagccgca aagcaccgcc 3300001 atgacatacc tcattgcatc gactccgagc atataaacga gaaatggaat gaaatacaag 3300061 acaaggatca taccgacagc tgaccacatg ccagctgaat taaactgatt ggccgccgct 3300121 cccgttccgg ccagcggcga aagtgaagcc gccacaatca cggcgcaaaa aagaaacgca 3300181 gaaatggttg tcatgatcgc cacgctattt ttttttgaca tcaaactcct cctttaatag 3300241 aaatattaac cttttttatt ataagtaagt tgaatgttat attcattata tttttaaaaa 3300301 attccagaat acatacacaa atgctatgct tctttctagt atatttatat agtaaaaaac 3300361 aaaggataaa agactcattt ttctgtaata tcaggatttt atcaccatac catattgcat 3300421 gtacatgttt ttcaaagtat actattccag attaattcag aggagagaga aaaatacatg 3300481 gaaaaaccag caggattttg gattcgtttt ttagcttatt ttattgacgg cattattgta 3300541 tctgttccta gttatattat tctatttatt atcaattctg tgtttgtagc tggggctgtg 3300601 gcaacaaacc cttacatgac ggaagaagag tatttagtga aatacatgac gcttgcattt 3300661 ttgcctacta tgctgatcat gatcgtcatc agcgtgttat attacgggct gctcacagct 3300721 tctaaaatgc aaggcacact tggcaaaaaa attcttggcc tgaaagtggt caatgaacaa 3300781 ggtgaacggg tttctgtcgg acagggaatt ggccgttact ttgcctatat cttatctgga 3300841 atcatctttt atatcgggtt tatcatgatc gcctttggag agaaaaaagg cctgcatgac 3300901 atcatttgca aaacacgtgt cgtgtataaa taatagaaaa aagtctagac gccaataggc 3300961 atctagactt ttgttttctt tgcaataggc tgccacgaca gatacgtagc gcttctccac 3301021 aaccactcaa acggccccat ccgaaagaca cgaagccaaa ggtggctgaa gaccatttga 3301081 acggcacaaa cagcaattgt aatgagcaca ccggcagcag ggtacacttt tccatacagg 3301141 cccaagccgt aatgataaaa aatccaagta cacacaatag actgcatcaa ataattggta 3301201 aatgccatcc tcccaacagc ggagaatgat tgcagcactg ttctcactct tgttttatga 3301261 taaagataga caaccgttgt aacatagaaa aacatgagga aaggcgcgcc aatcagcaaa 3301321 catatttctt tatccgttac actgtacagc acctgggcgc cgatgccgat gacaagccca 3301381 gccatccata atcgttttaa tcctttgcga tgcttttccg gttcatgcaa ataccgtgat 3301441 tttgctgccg cagctcccag caaaaacatg ctgaaatatg gaatggatgc aaagaagtag 3301501 ttgagcggat tatacgtaag catgccattc gaagacatgt aaacaagacg gtcgtggatc 3301561 cgctgttctg caatatcctt caggctgccg cttccataaa catgaatcgc ttgttttgcc 3301621 tgctgtgtta ccgcttgtac ccattcctgt ccgtttgatt gatcaaaact tgtcaacatg 3301681 aacggaatgg aaaacagaag atacaaagag accgcccata tcagcagtgt tttcggcttt 3301741 gcttttcgaa acaagagcag gacaaatccg agcagggcat attctgttaa aatatccccg 3301801 tcccatatca aaaaggcatg aatcgttcca aacaagagaa gcgccattaa ccttctcaca 3301861 tataacggaa caaaccgttt ccctttgttt tctgctctct ccatcatgac aaccatgcca 3301921 aatccaaata aaaaggaaaa caataaaata cattttgttt gaatgaagaa tttcagtatg 3301981 tctgcggcgg caaaatcagc ttcagaccac ttatccatga aaaaattctc ttttccaagc 3302041 atagacaaat acatatccgg ataactgaaa tgtgccagat tgacaaataa gatgccgaaa 3302101 atcgccattc ctctcagcac atcaagcaca ccgatccgct catttgttaa agtcggctgt 3302161 aatgaagaca tagccatcac gctccttttt tctgtacctt aagggtagga aaaaatgaag 3302221 cgcggtaaca tcgatttagg tgtcaggccg gcatgaaaac cttacaatct tgtcatcttt 3302281 atggtttcat cacctttaaa tctaatgctt cgatattctg caaaatgcga tcaaagcgca 3302341 aagcctgagg ctcacatggg aagatgtggc cttcatacgg gtcgcctaac gtccggaaaa 3302401 acggttcaaa taaaccagga accaatacgc ccaccatctt tgtatagtga gaatcaaggc 3302461 gataggagtg aacggtattt gcagggacat gcaggaaatc tcccggattc agctgaattt 3302521 cctggccatc tgtccacatc gtcatctggc cttcaaggca ataaaatgtt tctgtatgat 3302581 attcatggta gtgatcaacg attcggtcac ctttagggcc ttcagatgat acgacgataa 3302641 actggccatc tgtatttttt tgtgcagcca caatgcggtg aagctgatct ccagtcaaca 3302701 gacgatctcc ttctccagat tcaagaacgt atggaaccgc tccatctggc agctctgtaa 3302761 gttccgctaa tttggccgaa catgcaggct ttgcttcatc tagaaataca atgtccgcta 3302821 cagcggctgc ttctgcaaat cgctcgtttg agacttcttc gcttgcgtac ggcggatgtt 3302881 cagcgtgatc atacggattc ccaataacgg aatacaagtg cgctacgttt cctttcatcg 3302941 tgtaagacac cagtcttgtt ctgtggctct gcatccggta gctgtgcggt gttcccgccg 3303001 gaatgttggc ataatcacct gatattaata aatagcgttc accatcaagt gtcagttcca 3303061 gtttcccgtc caaaacgaga attccttcat gtgtgtcctt gtggacgtga agcggaaagg 3303121 catctccttt tcccccggaa agaagcacga tctcaaacaa atcacctgtg ctcctcccat 3303181 tcgccatcac cgtggcaacc tgtctgccga acagatagcg ctcgccttct ccgctccgga 3303241 gcaaataagg cattttttct ttaggcaatg aatgtgtaca taatgttttc atattatcgc 3303301 ttcctccaat ttagaccagt ctatatatta tcattcattt gtctagaccg ttctatataa 3303361 ttgtaggaga aaggataaca aaatgctacc ctttttttct caccagcact ggtatttgtt 3303421 cggcaatgag aagaagaggc gttttgtctt tattcgttaa cgaaagcatg atgccgccct 3303481 caatcatcga attaatcagc gttccaagct gatttgcttc ttcttctgca aatccgtttt 3303541 ccattaattt tctggcaaaa accgcttccc agcttttaaa caccttcatg caaaccgtcc 3303601 gcagcggttc actgattaac gctgtctcac tcgccagcaa accgactgga atacctttaa 3303661 tgctttctgt gttgtcaaat tggctggctg tttttttgat aaaaagctga atcgcttcaa 3303721 caggatcaga ggattcatcc atgctttgct gtatcagatg ttcaacgatc ttacctgtat 3303781 atgtaaccgc ttcaattgct agttcttctt tgccattcgg aaaaaagtga taaagcgatc 3303841 cttttggagc accgctttct tttacaatct ggttcaaacc tgtcgcgtga tatccttgca 3303901 gctggaacag acgtgacgcc gtgtgaagga ttttttcacg tgaatctcct ctgctagtca 3303961 ttaaaacatt ccctcctagg tatggtagag cgacttatat aatataaaaa agaaccctgt 3304021 gattgtcaaa aggggtaaga cccttccgga tggggtaatg tacaaaaaca gcgtctagga 3304081 gggatctctc aatgacaatc gatcattcag tcacaaatac agagcagctt gaacaacaga 3304141 accccgccat aaaaacaaag ctcaaactga aaaagcttaa ggatcaggtg atcgtcatta 3304201 ccggcgcttc aagcggtatc ggacttgtca cggcgagaat ggcagctgaa aaaggcgcaa 3304261 aggtcgtggc agcagcgcga aatgaagagg cgctgaagga gctcactgat gaacttaagg 3304321 aaaaagggca cgacgccata tgggtaaagg cggatgtcgg aaaagaagag gacgtcaacc 3304381 gcatcgcaga aaccgcgatc agcacattcg gccgctttga tacatgggtc aacaatgcgg 3304441 ccgtctcgac tttcggacac gccatggacg tcaccgtcga agacatgaag cgcatgttcg 3304501 acacaaattt ctggggacct gtttacggaa caagagcggc tgtcaaacac tacaccggca 3304561 gaggtgtgcc gggcgcactc attaatgtag gaagcctgtt cggagacagg ggaacggtca 3304621 ttcaatccac atatgcatct gccaaatttg cgcttcacgg ctggacggaa agcatccgaa 3304681 tggagcttga aaaggaacag gcgcccgtct cggtaacgct catccacccg ggcagaattg 3304741 acacaccata taacgagcat gcgcacagct acctcgacaa acagccggct cattaccgct 3304801 ccatgatcta tccgccggaa gcggtcgccg aagcgatcct gtttgccgcc gaacacccta 3304861 agcgcgacat gtacatcggc tcacaggcca aagccatcgc catgctgggc gcgctttttc 3304921 ctcgtctgac cgacagactg atggaaaaaa tcatgtatca cagccagcat gccgaaagac 3304981 cgtccaatcc gagagaagaa agcgctcttt atgatgctgg ctgcggtatg catgacagag 3305041 gcacaaataa aggatggatg aggtcaagaa gctactacac aaaagcgacg aagcgcccaa 3305101 ttgtatcggc ggctgttgtt gccggactag tggcttgggc tgccgccaaa cgatgcagat 3305161 aatctctgac cataagaaaa acccatgctg ttccagcgaa ccatgggttt ttcagctgtt 3305221 aatcgataaa agccttgttc atacgctgca gcagctcgcc gaacatctct ttttcctgtg 3305281 ttgaccattc tttcagcatc tgttcataac gttcaaggcg cttttgctga tcggctttta 3305341 atagttgttt gccgagtttt gtaatggtaa acaggctgac tctcccatca gacgggtctg 3305401 agaaacgata gatgagctcc tttgcctcta atgcagctgc ttgtcttgaa agagtagaaa 3305461 tatcaagctt aaacgattca gccaattcct taacacgagc aggcccaaac tcatccaatt 3305521 gtctcagtaa taagtacgaa gatctctcca aattccctgt tcttttctcc gattgatcca 3305581 gataaacagc tctcctgata aaagtcgtca gctcatattc aattaattca actggatttt 3305641 gattttgcaa tcgctctcgc tccctattcc aatctccggc attgacaaca tcatatatac 3305701 ttgtataata caaatgtaca ttaactgaat aaatacaagt cgttatatga ctaaatcaat 3305761 tattatactt gtatagtaca atcatataaa aagaaagtaa agcgattcct cagaaccatc 3305821 ctagaagcaa gcaccagaaa ggaggaagct gttctgattg gagagcagca cttgatgtga 3305881 aagtcatacg aattattttg caagtgttga tattatatgt attttttatg atcggggaag 3305941 ccattcagca tctgtttcat ttacccgtgt caggaagcat cgttggattg gtattgcttc 3306001 tgatctgctt gggcctccgt attgttcccg tctccatcat tgaagacgga gcagggtttt 3306061 tattatcctt ccttccattg ttgttcatcc cggcaatgac aggagtgata aactatccgt 3306121 ctctcatttc attcaatggc ctgatgctgc tgattacagt cgttctcagc accatcgtca 3306181 cgatcattgc ggctggattc gccagccagc tattagagaa aaaagcaaaa aaacgggagg 3306241 agaaagagaa atgcagcaag catgtatcgc gatcattata attcttttaa cagttgccgc 3306301 ttatttagcg atggtcaaac tctataagcg attcccgctt ccatttctga tccctgttct 3306361 gacaacgaca attttgattg tagcggcttt gatgatgttt catgtttcct atgaaggcta 3306421 tatgatcggg gggaaatgga tcaattcttt gcttgggccg gctgttgtgg cgctggccta 3306481 tccgctttat aagcaatggc atatcattgt caaacattgt gttcccattt taggcggcgt 3306541 cctggtcggc ttatgcatgg gaatgatcag cgggctgatc ttcgcagaag cattcgggat 3306601 tgatcatgat ctcttattat ccattctgcc aaaatcgatc acaacccctg tcgctattca 3306661 gatcgccgcc ggtcttggcg gcgtcccttc catgacagtc gtatttgtca tgattgcggg 3306721 cttttcaggc gtcatcctcg ggccgctttt cctaaaatgg cttcgcatac gcagctccct 3306781 aggacaaggc attgcattag gcagcgcctc ccatgcactg ggtacctcca aagcgttgga 3306841 atatggggaa ttggccgtat ccatgagttc cgtctccatg acgctttgtg cggtgctcgg 3306901 ctcattcttc ggcccgctcg tcgtctggct gtttcatatt taacaaagaa agactgcccc 3306961 gggggagggc agtctttttc gtttaagaag caaaaaaatc aatcaacggc tgaaagtcct 3307021 tagataaatc aacgtcattc ggttctgctt gaagcaggcg gtcaatcata cgctccagct 3307081 cctcaacatc attcttatcc gtatattcaa tgaagtttaa gctttcaagc caatcccgat 3307141 atgaatgttt ggctttgcca tagctgtttc caaagacaag gcaaggtgtt ttggtgataa 3307201 tcgagaaaat catcgcgtga aggcggtcgg taatcaccaa tttactggag ccgatgcggt 3307261 ccagcatctc cataaaatgc ttttcacgat cagcgtaatc gatggtgtct accgtatcca 3307321 gcaccgtatc ggtacgctct gtgtaagttg ttttttctgc ccattgcttc atctgtgaaa 3307381 taaaatcttc gtcagtcact ttctccttat ccgctcttaa aataaagaga acgccgtccc 3307441 gctcgagctc tcgcggcaca atatccaagg aaagcaccat gtccggtgta aagatcacat 3307501 tggagttgaa ggtctctttc acaacatcca gtgtttgcgt ctcacgcgca gcaatcgtta 3307561 agtttgtatt ttgatggtac gcatcctgtg tttttttctt ttccttctgt ccttcctctg 3307621 tatcctcaaa ataaacggat tgtggcagag aaattgattt gtagtcttta aacgccgaaa 3307681 agacctttct tctgtcttcc tcaatatcga gataaaggtt tcctaaattc cctccgcctg 3307741 taaagcagac aatatcgtct tcacgaatga tctccttcac cagttcaatg ccctcatccg 3307801 tcgcataatc cataatctca atgtattcat aatacggaaa atgatttttg ataaatttct 3307861 cttccgcata cgcaatcgct tggtcgccaa tgtttgtgta gctaggggaa ccaaacaaaa 3307921 atacttttcg tttatcattt aacagagctt ccggctccac atttggcgca atgcctttta 3307981 ctagtttttt gcctttgatt tcttgtacag tcatatctgc gtcctccttc tgggatgaat 3308041 tcctcattgt gtgttaactg tctctaccca aaaagaagga tggctatgca ttggcatgtg 3308101 catcggctat atcagaaaca tcgttttcgc caatttgata gacgctgcaa tgtcccgcgc 3308161 cgttctttcc atatattccg cggcatgttc aaacgcgtct tctagtggca cggctccggg 3308221 gacgatgctg aaaagcgcat cgattccgtg ttgatagacg gcattactgt ctcgggaaat 3308281 tgatcccgca atgccgataa cgggcacatc gtatgattta gcggccttgg ccaccccgat 3308341 cggtgttttt ccatgaaccg tttggctgtc gattcgtccc tcgccggtaa tcacaaggtc 3308401 tgcatcctga acgatacttt caaaatcaac cgcttcaagg acaatatcaa tgcctctttt 3308461 caggtcagcc tgaagataag ttagcaggct ccatccaaga ccgcccgctg caccggcgcc 3308521 ctctgtatct cggaaggttg atccgagcgc tttttctgcc atatcagcga aatggcttac 3308581 gttctggtct agtacatcca acatgtcggc cgtcgcgcct ttttgcggcc cgaaaacagc 3308641 cgtagcaccc tttggtcctg ttaacggatt gtccacgtca caggcaactt ccagtttgac 3308701 attccgcaat ctggaatcaa gcccgctcac atctattgat gcaagctgag ataacgcgcc 3308761 gccccctggg ccaatctcgc tgcctgagtt atcaagaagc cttccgccca atgcctgaat 3308821 catcccggct cccccgtcgt tcgtggcgct tccgccgatt ccgatgatca atcgctccgc 3308881 tcccgcatca agagctgctc cgattaattc tcccgttccc cttgttgtag tgatgagcgg 3308941 atttcgctta tctacaggca ccagatgcag ccctgaagca gcagccattt caatcacagc 3309001 tgttctccca tctcccatca tgccaaagaa agctctcacc ggttccccca gcggccctgt 3309061 gacaacttgc tctatgatcc ttccattggt cgcatcgacc agagattgaa cggttccctc 3309121 gccgccatcc gccaccggca attttctgta atcagcaccc ggaaagaccg atttgaaacc 3309181 tctttctatc gcttcggctg cctccagagc tgataagctt tccttaaaag aatcaggtgc 3309241 aatgatgatt ttcatccaaa tcgcctcttt caaaacatga ttcacttaac ctattgatct 3309301 ccaatgtacc ataattgatc tggaaataca taccatgcaa tatggtaaaa atttaaataa 3309361 aaattagaaa tgaaagtgtt tgcataaaag aaatattcac gttatcatac ttgtatacaa 3309421 gtatactcct tgagtgagga aggtgagtgt atgctagact ccaaagacct gttgtatccc 3309481 gcaaaatggc tctcaaaagc gtcaaccgga gttcgtgtcg catacgagct gagaatgcgg 3309541 atcgtttcag gtctgattga aagcggtacc attttatcag aaaatacaat cgccgccgag 3309601 ttttcagtaa gccgttcgcc ggttcgcgaa gcgctaaaaa tactcgcatc cgaaaaaatc 3309661 atccgcttag aacgaatggg agcggtcgta attggtttaa ctgagaagaa aatcgcggaa 3309721 atttatgatg tgcggttact attagaaaca tttgtctttg aacggcttgt caaaatagac 3309781 attgagcctt tagttaagga tctcagcaaa attcttgaaa tgatgaaagt ctcaatcaaa 3309841 tatgaggatg ctgacgaatt ttcatttcaa gatgtgctgt tccatgaaac gattatccga 3309901 gcgattgatc attcatacat tcagatgatc tggaacaatc taaaacccgt catggaaagc 3309961 tttattcttt tatcgatgcg ggtacggtta aaggaaaagt atgaagactt cacaaggatt 3310021 ttagataacc acgagcttta tattcaagcc atcaaaacaa aggatagggc gctgatgatt 3310081 cagtctcttc accaaaactt tgatgatgtg caggataagg tagaagacct atggctctca 3310141 caacaaatgc tggcaaaagg agctgaatac aacaatgact agttatatgt taggaatcga 3310201 tatcggcacg acaagcacaa aagctgtgct gttcagtgaa aacggagatg tggtacagaa 3310261 agaaagcatc ggctacccgc tctatacacc ggacatctca acagctgaac aaaatccgga 3310321 agagattttt caggcagtca tccatacaac agcgagaatt acaaaacagc atcccgaaaa 3310381 acggatctct ttcatttcgt tcagcagcgc catgcacagc gtcattgcaa tcgacgaaaa 3310441 tgacaagccg ctgacgccat gcattacatg ggccgacaac agaagtgaag gctgggcgca 3310501 taagatcaaa gaggaattga acggacatga ggtgtacaaa cggacgggaa caccgattca 3310561 tccgatggca ccgttaagta aaattgcctg gatcacgaat gaaagaaaag aaatcgcttc 3310621 caaggcaaaa aaatatatcg gcatcaaaga atacattttt aaacagctgt tcaatgagta 3310681 tgtcatcgat tactcattgg catcagcgac aggcatgatg aacctgaagg gcttggattg 3310741 ggacgaagag gcactgcgca tcgcaggcat cacgccggat cacttatcca aactcgtgcc 3310801 gacaaccgag atctttcagc actgcagccc ggaaatagcg atccaaatgg gaatcgatcc 3310861 ggaaacgcct tttgtcatcg gcgccagcga cggcgtgctg tccaacctcg gcgtcaacgc 3310921 cattaaaaag ggtgaaatcg ccgtcaccat cggtacaagc ggtgccattc ggacgattat 3310981 tgacaagccg caaaccgatg aaaaagggag aattttttgc tatgccttga cggacaagca 3311041 ttgggttatt gggggacctg tgaacaatgg gggcatcgtc cttcgctgga tcagagacga 3311101 gtttgcctcc tccgaaatcg aaacagcgac acggctgggc attgatccat atgacgtgct 3311161 gacgaaaatt gcccaacgcg tcagacccgg ttctgacggt ctgctgttcc acccatatct 3311221 cgccggagaa cgcgctccgt tgtggaatcc ggatgtacgc ggctcatttt tcggcttgac 3311281 catgtcgcat aagaaagagc atatgatacg cgcggcattg gaaggcgtca tttacaacct 3311341 gtacacggtg ttcttggcgt taactgaatg catggatggc ccggtaaccc gcatccaagc 3311401 gacagggggt tttgcaaggt cggaggtttg gcgccaaatg atgtcggata tcttcgaatc 3311461 agaggttgtc gttccggaaa gctacgaaag ctcatgtctc ggcgcctgca ttttaggcct 3311521 gtatgcaaca ggaaaaatcg attctttcga cgccgtgtcc gatatgatcg gcagcacata 3311581 cagacatacg ccgatcgaag actcagccaa ggaatacaga acattaatgc cgattttcat 3311641 caatctatca agattattag aaaatcaata tacacaaatt gcagattatc agaggggctt 3311701 aatcacacac aaatagtaca tgacatgaag gggagggcat taccatgccg ttaatcatcg 3311761 ttgcacttgg gatcttagca ttactatttc tgattatggg cttaaaatta aacacattta 3311821 tttccctgct ggtcgtatcg ttcggcgtgg cactggcact cgggatgccg ttcgataaag 3311881 ttgtcagctc catcgaagca ggaatagggg ggactcttgg ccacatcgcg ctcatcttcg 3311941 gactcggtgc gatgctgggc aaactgatcg cggattcagg aggcgcacag cgcattgcga 3312001 tgacgctcgt caacaaattc ggtgagaaaa atattcaatg ggccgttgtc attgcctcat 3312061 tcattattgg gattgcgtta ttttttgaag taggactggt tctattaatt ccgattgtct 3312121 ttgcgatttc aagagaattg aagatttcta ttttatttct cggaatcccg atggtcgcgg 3312181 cactatccgt cacacacggt ttcctgccgc cgcacccggg acctacggcg atcgccggtg 3312241 agtatggcgc aaacattgga gaagtgctgc tgtacggctt tatcgttgct gttccgacag 3312301 tgctcattgc agggccgtta tttacaaagt tcgcgaaaaa aatcgttcct gcatcatttg 3312361 cgaaaaacgg caatattgca tcactcggca cacaaaaaac atttaacctt gaagaaacac 3312421 ccggctttgg aatcagtgtc tttactgcaa tgctcccgat tatcatcatg tcggtcgcga 3312481 ccattatcga cctgcttcaa gaaacaatcg ggtttgcaga taacggagtt ttagctttta 3312541 tcagattgat tggaaacgca tcgactgcta tgattatttc gttattggtc gcagtctata 3312601 caatgggcat caagcgcaac attccagtca aaaccgtgat ggattcttgt tcaactgcca 3312661 tttcacaaat cggcatgatg cttttgatca tcggaggagg cggcgccttc aaacaagtgc 3312721 tgatcaacgg cggtgtcggc gattacgtag cagacttatt caaaggaacg gcattatcgc 3312781 caatcattct ggcatggctc atcgcagcga tcctgcgcat ttctctagga tcggcgactg 3312841 ttgccgcact aagcacaaca ggtctggtca ttccgttatt gggccattct gatgttaacc 3312901 tggcgttagt cgtactcgca acaggagccg gaagtgtcat cgcttcacac gtcaatgacg 3312961 ccggcttctg gatgttcaag gaatacttcg gattaagcat gaaagaaaca ttcgccacat 3313021 ggacattgct ggaaaccatt atttccgttg ctggactggg attcatttta ttgttaagtt 3313081 tagttgtatg aaattaagaa ggagctgtaa cacatgttca attcgattgg tgtcataggc 3313141 ttaggcgtaa tgggaagcaa catcgcctta aacatggcaa ataaaggcga aaacgtcgct 3313201 gtctataatt acaccagaga tttaacggac cagcttatcc aaaagctgga tggacaatct 3313261 ctcagcccgt attacgagct tgaggacttt gttcaatcgt tagaaaaacc aagaaaaatc 3313321 tttttgatgg tcacagcggg aaaacccgta gattccgtca tccaatcatt aaagcctttg 3313381 cttgaagaag gcgacgtcat catggacgga ggaaactccc actatgaaga cacagaaaga 3313441 agatatgacg agctgaagga aaaagggatc ggctacctgg gagtcggcat ttccggcggt 3313501 gaagtcggtg cgttaacagg gccttccatc atgccgggcg gagatcgcga cgtctatgag 3313561 aaagccgctc ctatcctgac gaaaatcgca gcccaagtcg gagatgaccc ttgctgtgtc 3313621 tatatcggac caaaaggggc agggcacttt acaaaaatgg tgcacaacgg cattgaatat 3313681 gccgacatgc agctgattgc agaagcttat acgtttctaa gagaaacgct tcgtctgccg 3313741 ctagatgaaa ttgcatctat ttttgaaaca tggaatcaag gtgagctgaa aagctattta 3313801 atagagatta cagctgagat tttacgcaaa aaagacgaaa aaacaggaca gcctctgatc 3313861 gatgtcatcc ttgataaaac cggccaaaaa ggcaccggaa aatggacgag catgcaggcg 3313921 attgataacg gcatcccgtc cacgatcatc acagagtcct tgttcgcccg ctacttgtca 3313981 tctttaaaag aagaacggat ggcagctcaa gatgtattag caggcccgga agccgaagaa 3314041 aaacacttgg ataaagacac ttggattgaa tacgtcagac aggctcttta catggggaaa 3314101 gtatgcgcct atgcacaagg ctttgcccaa tataagatgt catctgagct ttacggctgg 3314161 aatctgccgc tcaaagacat cgccttgatt ttccgaggcg gctgcatcat ccgcgctgat 3314221 ttcctaaacg tgatcagcga agcattcagt gagcagccaa atctggctaa cctgctgatc 3314281 gcgccttatt tcacagataa gctccatgcc tatcaaacag gcctgcgaaa agtcgtttgc 3314341 gagggtatca gcaccggaat ctctttccca tgcttaacta ccgcgctctc ttattacgac 3314401 ggctaccgca cagggcgttc caatgcgaac ctcttgcagg cacagcgcga ttactttggc 3314461 gctcacacgt acgaacggac tgatatggac ggcgtcttcc atacgaattg gtctgaataa 3314521 cctgtattaa aaacacggtc agtttcaact gaaccgtgtt tttttcttct atcccaaaca 3314581 acagaagaca taagttatgt tttaaatatc ataaacagtg atacaataat agctagaaac 3314641 aatccccaag atcatcatgt gacagcagat tgctgttccg ttctattctg cttttggcca 3314701 ttgtcctttg cccttgacca tggtgtcata aaatgttcaa atgccaaaac ggcctggcat 3314761 tctgatttac aaaagtccct gaaaacctta tctaattgag aatcagcctc tcatttatta 3314821 taaaagaaat gcctaaatcc tacctgtcac acctttatta agatgaaaaa aagtaggtta 3314881 tggcttgaca aaaaatatat attaattaat aattcatata taattagaat tattattgaa 3314941 agcgattatg ctttctaata catttttagg aggaatatac attatgtctt taatcggtaa 3315001 agaagtactt ccattcgaag caaaagcatt caaaaacggt gaattcatcg atgtaacaaa 3315061 cgaagatttg aaaggccaat ggagcgtatt ctgcttctac ccagcagatt tctctttcgt 3315121 atgcccaact gagcttgaag atcttcaaga acaatatgct gcacttaaag aattaggtgt 3315181 tgaagtatac tctgtttcta cagatactca cttcgtacac aaaggctggc atgacagctc 3315241 tgaaaaaatc agcaaaatca cttacgcaat gatcggtgac ccatctcaaa cgatctctcg 3315301 caacttcgat gttcttgacg aagaaactgg ccttgctgac cgcggaacat tcatcatcga 3315361 tccagacggc gttatccaaa ctgttgaaat caatgcaggc ggtatcggcc gtgacgcaag 3315421 caaccttgta aacaaagtaa aagcagctca atacgttcgt caaaacccag gtgaagtttg 3315481 cccggctaaa tgggaagaag gcggcgaaac tcttacacct agccttgatc tagtaggtaa 3315541 aatctaagga gtgcattcaa ttggtacttg atgcaaatat caaagcacaa ttaaatcaat 3315601 atatgcagct aattgagaat gacattgttc tcaaagttag cgcaggcgaa gatgacactt 3315661 ctaaggacat gctggctctc gttgatgagc tggcttccat gtcatcgaaa atttcagttg 3315721 aaaaagctga attaaacaga acgccgagct tcagtgtcaa tcgtgtcgga gaagacactg 3315781 gcgtgacttt cgccggtatc cctctgggcc acgaattcac atcattagtg ttggcgttgc 3315841 tccaagtgag cggcagaccg cctaaggtag accaaaaagt cattgatcag gtgaagaaga 3315901 tcagtggtga ataccacttc gaatcttata tcagcctgac atgccacaac tgtcctgatg 3315961 ttgtacaagc tttaaacatg atgagcgtgc tgaacccgaa cattacgcac acgatgattg 3316021 acggtgcagc atacaaagca gaagttgaaa gcaaaaacat catggcagtg ccgaccgttt 3316081 acctgaatgg cgaatccttc ggaagcggcc gtatgacgct tgaagaaatt cttgcgaaaa 3316141 tgggcagcgg cacagatgca tctgagtttg ctgacaaaga gccgtttgac gttcttgtgg 3316201 tcggaggcgg acctgctggt gcaagtgcag cgatctacac tgcacgtaaa ggcatccgaa 3316261 ctggtgttgt cgctgagcgc ttcggcggac aggttctcga caccatgagc atcgaaaact 3316321 tcatcagcgt caaagcgacg gaaggaccga agctagcggc aagtcttgaa gagcatgtga 3316381 aggaatatga tattgatgtc atgaaccttc agcgtgcgaa acgccttgag aagaaagatc 3316441 tgttcgaact tgaactcgaa aacggcgctg tcctgaaaag taaaacagtg atcctttcaa 3316501 caggtgcacg ctggcgcaat gtcaacgtcc ccggtgaaca agagttcaaa aacaaaggtg 3316561 tcgcatactg cccgcactgt gatgggccat tgtttgaagg caaagacgtt gcggtaatcg 3316621 gcggcggaaa ctctggtatc gaagcagcga ttgatcttgc aggtattgtc aatcacgtta 3316681 ctgtactaga attcgcgccg gaactgaaag cagacgaagt cctgcaaaaa cgtctctaca 3316741 gcctgcctaa cgttactgtc gtgaaaaacg cacaaacaaa agaaatcaca ggtgatcaga 3316801 gtgttaacgg catcacatat gtagaccgcg aaacaggcga agaaaaacac gttgaacttc 3316861 aaggtgtatt cgtccaaatc ggtctcgtgc caaacacaga atggttagaa ggaacggttg 3316921 aacgcaaccg catgggcgaa attattgtcg acaaacacgg cgcaacaagc gtaccaggct 3316981 tatttgctgc cggcgactgc acagacagtg cgtacaacca aattattatt tctatgggat 3317041 caggtgcaac tgccgccctc ggcgcgtttg attacctaat ccgtaactaa tataagaaat 3317101 ccgctatatt gccagattgg caggatagcg gatttttctt tttctacaga aaaaaaccga 3317161 accaggcact acggtaaaag tgctcgattc gagcgcttct tatagttcct caccattcgt 3317221 ttgaatgaca tttttatacc actcaaagga gtctttctta tatcgtttca tggatccgtt 3317281 tccttcattg tcacgatcaa catagatcat gccgtagcgt tttttcattt cgccagttgt 3317341 gaaggagaca atatcaataa tgccccacgg cgtgtagcca attaaatcaa caccatcgta 3317401 cgtgaccgct tttttcaatg cttcaatatg cgattttaaa tattgaatgc gttccggatc 3317461 atgaaccttg ccgtcctcct ccagcgtatc cactgcgcca aagccatttt caacgatgaa 3317521 taacgggatt tggtatcggt cataaaaacg atttaacgta tatctcaacc cggttggatc 3317581 aatcgcccat ccccagtcac tcgaagtgat gtacggattt tcgacaccat tcggcaagcc 3317641 gccatttaca atatcgccag tgttatcatt tttcacatcg cttttcacag ttgttgacat 3317701 gtaatagctg aagcctaagt aatcgacggt tccgtttctt aaaatctcat catcgccgtc 3317761 ttcgaatgtg atgttgtagc cttcgcgttc aaattccttc aacgcgtagc ttggataata 3317821 accgcgaacc tgcacatcag ggaagaaata gcgctgcctc atttcttctt cagccagcat 3317881 cacatcttca ggattggagg agaaaggata aatcggcacg tgtgatacca tggccccaat 3317941 ctggaactct ggattgatgt cttttccttt tgccactgct aaggcgctcg ccactaattc 3318001 atggtgcgcc gtttgataca tgacttcctt ggcgttttcg ttttcgccaa ccacaacacc 3318061 tgaattcgtc cataggaaca gcggattgtt cacatccatt tggttgttaa tctcgttaaa 3318121 tgtcatccag tacttcactt tatctttgta acgggtaaag caagcctctg cgaagttgac 3318181 gaagaagtcc acgactttcc ggtttctgaa gccgccatat tctcttgcca ggtgcagcgg 3318241 catttcaaag tgagacaggg taatgaccgg ctcgatccca tgcttcagca attcatcaaa 3318301 cacatcatca taaaactgca aaccagcttc gttcggttca gcctcatcgc ctttcggaaa 3318361 aatccggctc cagccgatgg acgtccgcag acattttaat cccatttccg caaacaaagc 3318421 gatatcttcc ttgtatctgt gatagaaatc aatggcttca tggtttggat aaaattcgtt 3318481 ttcttcaatc gtgtcagtga tttttctcgg cacgccgtgc gcacccgctg tcatcacatc 3318541 gacgacactc ggccctttac cgccttgatt ccatccgcct tcaaattggt gggcagctaa 3318601 agcaccgccc cataaaaaat cctttggcat gtttcccatg tttaattcct cctcagctta 3318661 cgactgtaaa tattttttga tgtaatgcac tttcctcaat gtcttcaatg aaagctttat 3318721 caaactcaac aagcacttcg ccttttttga cggtatcgcc ttcttttacc ttcaaggaaa 3318781 aaggcgtgcc gtcaaatgtc accgtatcca gcccgatgtg cgcaagcaat tcgacgccgg 3318841 acgctgaacg caggccaatc gcatgctttg taggcgtaac catgacaacc gtaatgacgc 3318901 cgggatggta gcatcgattt cacgatatcc ttcgctttag gggtagaccg cttcagcacc 3318961 aatcgaagtc tggtagcgca gcgagaagcc ccaatcacat tctcttcccc gcctacggcc 3319021 tctaaaatgt cttttgctag tctcgtataa tctctcactt tccccgacat ttcacccacc 3319081 ccttcgtttt ggttacgctt tcattataat tgtaacggta taatttatca attccgaaac 3319141 aaaatattta cgcactaact atcattgtaa gcggtttatg ctataatttt gacaagtgaa 3319201 actaaacgaa taaatgagga atgcgtatgt taaaatacca gcaaatcgca acggaaattg 3319261 aaacatatat agaagaacac cagcttcagc agggagacaa actgccagtc ctagaaaccc 3319321 tcatggccca gtttgaagtc agcaaaagca ccatcacaaa gtccctcgag ctattagagc 3319381 aaaaaggcgc gatctttcag gtcagaggaa gcggcatttt cgtcagaaaa cataaacgaa 3319441 aaggctatat cagccttctg tcgaatcagg gatttaaaaa agatctcgag gatttcaacg 3319501 tcacctcaaa agtcatcgaa ctggacgtga gaaagccaac accggaagcg gcggaaaacc 3319561 tgaacatcgg aatggacgag gacatctact atgtcaaaag ggtccgctac atcaacggcc 3319621 agaccctttg ctacgaagaa tcctattaca ccaaatccat cgtgacgtat ttaaacaacg 3319681 aaatcgtctc ccactccatc ttccattaca tccgggaagg actggggttg aagattggtt 3319741 tttctgattt gtttctgcac gtgggccagc ttaatgagga agaagcggaa tatttgggat 3319801 tagaggctgg actgccgaag ctgtatatag aaagtatttt tcacctgaca aatgggcagc 3319861 cgtttgatta ctcgaagatt tcgtataatt atgagcagtc gcagtttgtg gtacaggcta 3319921 atagtttttt attatagggc tcttcactac ggtaggtggt cgacatgtac aaaattatca 3319981 ttcctgccat actagccatc tttgcgctct ggatactctt acagatttca ctagagatga 3320041 gcatcgttaa gaatccaatg aactacttta tcgtattcat tatctttttc ctctttgtaa 3320101 agatggtgaa agaaaaacaa taatagtttg ggcgatgcaa acagaaaaac atccttccct 3320161 taacaaactc agccagtcac atgcattaat cttgatgtta atgatatata ggtgcacata 3320221 aaaagctact tcattgtgaa gtagctccct ttattaaagg cccattttga tccatctagt 3320281 tttagaaaag cgaaggacaa tcgcatttat gataataatt gaaactaaat acaaaataat 3320341 aaataaaaca tcattactcc caagtgtcat gttatcagat tgcagcactc tttctattcg 3320401 ggggtacata gtgttacctg cctcaaaagg agcaatgaaa ccaaacgttt tattgcttat 3320461 agctactaag ataacagaag tcatccaata aacgatactg acacctatac taattaatat 3320521 attaggacat aacacgctta tagttccgat aattagaata tactgcagta taactgcaga 3320581 aaataaaaaa agtaataatg caaaatgcga aaaatcatgg tacatcaacg atatgattag 3320641 caggcctagc gttataaatg caaaacattc taaaaataaa acagctatct ttttataaaa 3320701 gaaagtatag atgttctctc caattaactt gtaaaagaga atatttttgt ttgaatactc 3320761 tctattaata aagaaagcta taacaaatga aaataacatc aaaccaaact gggtcgcaac 3320821 agtataggag ctaaagaaaa acatttcagg tgtaacatta ctgactttat cgattccaac 3320881 aagtaaaaaa taacccagca aaaataaaaa tacaaacatt gctcctaaaa taatgataac 3320941 tttgttgcta atactctttt taaactctaa tttcatctca agcccccact gttttattac 3321001 tcatttatat acacttcaat taatttatcc actgaatgat attgttgaat ttcttggtga 3321061 ttaaatatat aataatcccc ttctatcgcc tttaaatcag acaaatcatg tgtaatgttg 3321121 atgataatct tctcggggtt ctcctgaata tacttgttta agaagccatg aatctctata 3321181 accgtttttt tgtctaatga attcgttatt tcatctaaaa caataatatt tttatcctct 3321241 aataagaaac tgagcaattt taatttttgc ttttgtccat cactcaaatt tttgatcaga 3321301 acttttccat caatattatc cagattaagt aaatatgcga ttttatctat catttttgca 3321361 tcaaattttt tactcaaaaa gtgtaataaa aagtccttag aaacatcatt aggtatattc 3321421 gacgagctgg atattaaaga aacattttga cgaatatctc tgccgattct tttgctatta 3321481 ttcaacaaaa agtctttagc aagctgtgat ttaccgactc cattttttcc gacaacgtga 3321541 ttaattttcc cgctcgaaaa atgcaagtcg gtgtcctgaa gtaacgtttt gcctttcact 3321601 tttaaagtgt aattcgctat attcatatac atactcctag gaaatatttg cataataata 3321661 aaatgttctg ccttgtgatt tgttactaat gtctaagctt ttgaggtacc tctttcgttt 3321721 ccgatccgga agcgaaagaa atgtttttag atggctaatt tggagatctt ttactctagt 3321781 ttacaatata taatatccaa tgtacaactg aattcactgc aaggccaatc cctataattt 3321841 gaatcgtaag aactaaccaa tgatttgtct taaaacggct atattcatct aagctcagaa 3321901 aagctaaaag aattttgtaa ccatcagaat tcaatattgg gattaagttc cacaataaag 3321961 tagacgagaa aagcataaat gccatagtta atgcttcact ggaaaatgta aattgattta 3322021 ttaattctaa tgtatttatt aaaagataat tgataaacaa gccaaataaa tgaacgatta 3322081 tcttttcatt tcttgatagc atgtaggttt cattcaattg gacataaaaa gcaggaaata 3322141 cataaaaatt cagtttgaat cccactttat caaagttttt cccgaaaaat tttaaggaat 3322201 aaatatgtcc cagttcatga agcactatat tcattataaa ataaataact ataattatcc 3322261 acattttcca gccgtaaaat actgaggaca atccattttg caattttatt aaatgaatat 3322321 aatttaatat gaacatgaga gccgtaaagg ataagaacag ataaaaaaac tttggtgata 3322381 ctttctcttt atacatttta aaacgtaata attgtttatc tgacagagaa tttaaactat 3322441 ttttatagta ttctccgctt tttttgtctt ttataaatac gttgttttgc acaagcactt 3322501 catatttttc atcttcatac tttaaaattt tcattatagt atttttccat ataaggatag 3322561 aagtagttta ttttttctgc agagttgaat aaggaaccac aaactccaca aatagaggaa 3322621 aattcataag gaatgtcaaa ttcctctatt ttgttatttt cttttaaaat attcaaaaac 3322681 catttgaatc cttcttttct aagaataaat aatagcaaat tggaatttaa cttttccacg 3322741 gttctttcga aactttggtt atattcttcc cttagggtta ttttcgtttc aaaaatagca 3322801 ggggaacaac atggataaat ttctccatca tgatgatata caatgtcata tccgggacaa 3322861 tgtaaggaat cttcatcttc aagactgtaa aatttatgta tgttttcttg cttaattcta 3322921 gttttagcag cgccaactga tatcattgga aattttgtta tctttacacc taagattgaa 3322981 tcccccaatt cctctaaaat gtggttggac attttgtctt tggtaactgc catattaaga 3323041 gaaatatcga tatcagggta tttcctgcta tgttctaata tgtttttaat actggaagac 3323101 ttgacaaatg gagcatggta ctcatcataa cttatagtca gtgctatcac atttaaagaa 3323161 ttcatatcat gaaagtactc ctggaccttt ttcttgctca aaccccaaaa tccattagag 3323221 atcaacgtta tttgtttttc atatggttta atgatttcca ttagttcttt taaaaattta 3323281 taatctaaaa aaacttcccc acctgtaaaa gaaatcactt gaatggtttt gttttttgca 3323341 aattcagtta ctaactctct tatgtattct ttttccatcc tggttgttga agttggtgaa 3323401 ctagaaaaac aacaatggtc acaggatgca ttacaccttg aatctaaatt gattgatact 3323461 gttttattat acatgaaata tcccccaaca aatggtaaag gagagttaga ctctcctttg 3323521 tacccctcta attaatgacc acttccaaga atccagcgat tttcttttga ttttacaaaa 3323581 taccaaagat cattcacttt tgctaacttt tgtgattcat ctaatagacc cttaaattct 3323641 aagtttttca cagtctcatt gttagtgatt tcctttttca tattatccct cctccttttc 3323701 taatataaac caattattct atatcattca atacatgtca atatattgta cctaaaaaat 3323761 ctgaaaaatg tcactattct tggtatataa agcctatagt cctctagccc ctctaagcta 3323821 taccgaatga aaggccatag tttgatttaa agcttcgtaa tgaaaagtaa aacatcaata 3323881 ttgactacac tagttaaggg atatacagat tttaagtgga agaaatgagg caaacaatct 3323941 taccctaaac caacctgtac tgaaaagctg ttttaagctc ttgcttaccc catttggcac 3324001 ctctttctct cgttttaatt gtctctaaaa gcagttatgc ggtactatca tataaaggtc 3324061 caatgtttaa aaataatgtc atacttttaa attcacctta tcatgcacat gctcataaag 3324121 aggggtttat tctaaaaagg ggatggacgg ttttggaaag caagtaccta gatctactcg 3324181 cacaaaaata cgattgtgaa gaaaaagtgg taacagaaat catcaatttg aaagcgatat 3324241 tgaacctgcc aaaaggcacc gagcattttg tcagtgatct gcacggagag tatcaggcat 3324301 tccagcacgt gttgcgcaat ggttcaggac gagtcaaaga gaagatacgc gacatcttca 3324361 gcggtgtcat ttacgataga gaaattgatg aattagcagc attggtctat tatccggaag 3324421 acaaactgaa attaatcaaa catgactttg atgcgaaaga agcgttaaac gagtggtata 3324481 aagaaacgat tcatcgaatg attaagctcg tttcatattg ctcctctaag tatacccgct 3324541 ccaaattacg caaagcactg cctgcccaat ttgcttatat tacggaggag ctgttataca 3324601 aaacagaaca agctggcaac aaggagcaat attactccga aatcattgat cagatcattg 3324661 aacttggcca agccgataag ctgatcaccg gccttgctta cagcgttcag cgattggtgg 3324721 tcgaccatct gcatgtggtc ggcgatattt atgaccgcgg cccgcagccg gatagaatta 3324781 tggaagaact gatcaactat cattctgtcg atattcagtg gggaaatcac gatgtccttt 3324841 ggatcggcgc ctattccggt tccaaagtgt gcctggccaa tattatccgc atctgtgccc 3324901 gctacgacaa cctggatatt attgaggacg tgtacggcat caacctgaga ccgctgctga 3324961 acctggccga aaaatattat gatgataatc cagcgttccg tccaaaagca gacgaaaaca 3325021 ggccagagga tgagattaag caaatcacaa aaatccatca agcgattgcc atgatccaat 3325081 tcaagcttga gagcccgatt atcaagagac ggccgaactt taatatggaa gagcggctgt 3325141 tattagagaa aatagactat gacaaaaatg aaatcacgct gaacggaaaa acatatcaac 3325201 tggaaaacac ctgctttgcg acgattaatc cggagcagcc agatcagcta ttagaagaag 3325261 aagcagaagt catagacaag ctgctattct ctgtccagca ttccgaaaag ctgggccgcc 3325321 atatgaattt tatgatgaaa aaaggcagcc tttatttaaa atataacggc aacctgttga 3325381 ttcacggctg tattccagtt gatgaaaacg gcaatatgga aacgatgatg attgaggata 3325441 aaccgtatgc gggccgtgag ctgctcgatg tatttgaacg attcttgcgg gaagcctttg 3325501 cccacccgga agaaaccgat gacctggcga cagatatggc ttggtattta tggacaggcg 3325561 aatactcctc cctcttcgga aaacgcgcca tgacgacatt tgagcgctat ttcatcaaag 3325621 agaaggaaac gcataaagag aagaaaaacc cgtattatta tttacgagaa gacgaggcaa 3325681 cctgccgaaa catcctggca gaattcggcc tcaatccaga tcacggccat atcatcaacg 3325741 gccatacacc tgtaaaagaa atcgaaggag aagacccaat caaagcaaac ggaaaaatga 3325801 tcgtcatcga cggcggcttc tccaaagcct accaatccac aacaggcatc gccggctaca 3325861 cgctgctata caactcctac ggcatgcagc tcgtcgccca taaacacttc aattccaagg 3325921 cagaagtcct aagcaccgga accgacgtct taacggtcaa acgattagtg gacaaagagc 3325981 ttgagcggaa gaaagtgaag gaaacgaatg tgggtgagga attgttgcag gaagttgcga 3326041 ttttagagag tttgcgggag tatcggtata tgaagtgagg ggtgtggggt tcagggatgg 3326101 tgatatgcgc tgagaaaatg attggataaa tgaaaaaccc ccgcgggatg cgggggttca 3326161 atttaacgaa agaatcctaa aacggtttgt agttttagga ttctttcatc ttttcagcgt 3326221 gattgaaaac ccttgaagtc taggaagaac gagcattgga gcgcagcgaa tgtttggaat 3326281 tcgtgagcac cgaagcgcag gcctgacaac gaatgcgagg gtttgtcgac acgctgaaac 3326341 ccccgcgggt gcgggggttt tcttattaca gcagcttctt ccctaacagg gattctacga 3326401 gctctactgc tgttttgccc gttttgtttt tgtgatcaag gatcgggtta acctcaacga 3326461 attcggctga ggtaatgatg cctgcgtcat acagcatttc catagccaaa tggctctccc 3326521 ggtagctgat gccgccgacg acaggggttc cgacacccgg tgcgtcgttc ggatcaagtc 3326581 cgtccagatc aaggctcaga tggacgccat cacatgctga taaataatca agggtttctt 3326641 caatgacctt tgtcatgcca agacgatcga tttcgtgcat tgtgtacacc ttcatgccgc 3326701 tttccttaat gtacttgcgc tccccttcat caagtgaccg ggcgccaatg atgacgacgt 3326761 tttccggttt gattttaggc gcgtagcctt caaggttaac cagtgactcg tggccaatgc 3326821 ctaggctgac cgcgagcggc atgccgtgaa tattgcccga tggtgaagtt tcaagtgtat 3326881 tcaaatcgcc gtgcgcgtca taccagatga cgccgagatt atcgtaatgc ttcgctgtgc 3326941 ctgcaagcgt gccgatcgca atactgtggt caccgcccag gacaagcggg aattttttct 3327001 cttcaatgac tttgttgacc ttttgcgcga gtttttcatt tcccgccaaa acggaattca 3327061 ggtttttcag ttcctcgtca tttttgattt tttcgcgatt gatcggaatg tcaccgagat 3327121 cttcaaccgt ataccccatg tctgacagcc tctcgatcag atgagcgtac cggatggcac 3327181 tcgggcccat atccactccg cgtcgtgctt gtcctaaatc cattggcatt ccaataaccg 3327241 aaatcgtttt atccatctgt gattccacct caacatttaa gataatgtcc tatgcgggtt 3327301 ataacaaaga tgacttgcgg acaacgtttt taaagctcta gctgacgatt tgcctgctgg 3327361 cgttttttaa tgacgacatg ataaatgatg tagcaaatga tcataaacgg tacgccgcaa 3327421 tacagcgcga tacgctgctc cggatcaaat gcaagactga tgagcacgac cgtatttaac 3327481 gttaggccga tcagcggaag caccgggtac agcggtgttt taaatttcaa atcttctatc 3327541 ttcccgccct cacggatata tttgcgtctg aacatgattt gggaaagcga gatcgtaatc 3327601 cagccgacct gcgcgctcat gcccgccaaa gataacagta ccatatatac ggtttcagcc 3327661 tgcgcaaact ttgtcagaag tgataggcag gccacagcca tcgttacgat taacgagtac 3327721 atcggtacac cgcgctgatt tgttttgcca agcgctttga aggcttgtcc ttcattcgcc 3327781 atcgcgtaca gaatacgtgt tgatgcgtat aaacctgagt tcgcaacaga taacagtgcg 3327841 attaaaataa caaagttcat gatatcagct gcatatggga ttccgatttg ctcaaatacg 3327901 gcaacaaatg gactttccac gacacccgcc tgtttccacg gaatcatgcc ggcaatgaca 3327961 atgattgaaa gcacaaagaa cacaagcgtt ctccatactg tctgtttgat ggaccgcgga 3328021 atcgtttttt cagggtcttc actttctccg gctgcaaccc cgatcagctc agtcccctga 3328081 aacgcaaagt tcacagtaat catcgtaatc agcattgcct ttatgccgtt cggaaataac 3328141 ccgtcttcat aaaaatgtgt caaaaacggc gcctgctctc cgcccttcag atcaatcagg 3328201 ccaaacatgg cagctccgcc gagaataata aataaaagga taatcaaaat tttaatgcct 3328261 gagaaccaga attcagattc cgcaaaggct tttgtggtga tcgcatttaa aataaacatc 3328321 agtgccgcaa agaccagaca ccagatccac acgtctatat gcggaaacca gcgttgcatc 3328381 agctgccccg ctgataaaaa ttcaatggcg catgtaaccg cccagccgag ccagtacagc 3328441 cagccgaacg caaacccgaa ggccgggctg ataaatttcg tggcataggt ctggaaggac 3328501 cccgacacag gaaaggcgac tgccagctct cctaagcaga gcatggtcaa aaacatgata 3328561 aagccgccca ctaaatagga cagaaccgcg ccgagcggtc ccgcttggtt aatggtaaac 3328621 ccggttccaa ggaagaaacc ggttccgatc actccgccca atgaaatcat gaacaaatgg 3328681 cgtgatttca ttgtccgctg gagctgattt ccgttatctt ggtttgtatt cacattctgc 3328741 accccttcag caacttgtat tggatctaag ctggaacatc tgcatggtgc tatcccagtt 3328801 tgctgtccaa agagtctcta tctatttaat ataaaattca cttcttctca taaagataca 3328861 ttatactaaa atactgtagc tgagcaaata gggagtgctg atttttctgt tgtaaattta 3328921 tacaaacgaa gtgaatatcc cgccatggtg cggatttatg cgtttcgcag cacgtgctta 3328981 attttctcta tcgcccaatc caagtcctct ttggaaatga ttaatggcgg tgcaaaacga 3329041 atgactgtat catgcgtttc cttgcataaa agtccctctt ccttcaaacg ctcacaatac 3329101 ggacgtgccg cttcagtcaa ttccacaccg ataaacagcc ctctgccgcg gacttcttta 3329161 atgacagggc tgtcaatact ctcaagctcg cttttaaagt attcaccaag ttcaagagaa 3329221 cgatccgcca gcttttcatc ctccagcact tctaatgaag cgatagacac tgcacatgca 3329281 agcgggtttc caccaaatgt tgagccgtgt gagccagggt taaacacgcc taggatctcg 3329341 cggtccgccg caatgcaaga gatcgggaac acaccgccgc caagcgcttt gcccaagata 3329401 tacatatccg gaacaatgcc gtcccagtca caggcaaacg tcttgcctgt acgtccgaga 3329461 cccgtctgaa tttcatccgc aataaacaag acattctctt ccttacaaat cgccgccgct 3329521 tcctgtaaaa atccttcagg cggaatcaca atgcccgctt cgccttgaat cggttcaaac 3329581 aagaatgccg ctgtattcgg cgtaatggcc tgtcgaagcg cttccacatc gccgtaagga 3329641 atgagtttga ttcctggaag catcgggccg aatcctcgtt tatattcctc ttcagaagaa 3329701 agagataccg ccagcatcgt gcggccgtgg aagttcccga cacatgcgat aatttccgct 3329761 tgattgtcag ctacgccctt cacttcatac gcccagcgtc tcgccgcttt caccgcggat 3329821 tcaaccgctt cggctcctgt attcatcggc agaatcatct ctttgcctgt cagtttagct 3329881 gttttttcgt aaaacggccc aagctgatcg ttatgaaacg cgcgtgacgt gagggtgatt 3329941 ttatcagcct gatcctttaa tgcctgaatg attttcgggt gtctgtgccc ctggtttacc 3330001 gcagagtaag cactcagcat atccatatat tcattgcctt ccgggtcctt tacccaagca 3330061 cccagcgctt cagaaataac aatcgggagc gggtgataat tgttggctcc gtaatgagac 3330121 gtctgatcaa taatttcttt ggatttagat aaagctgtca tatttgaatt cccccttgtt 3330181 ttctgtttca acatgttatc ctgctttccc tttatataaa tgcaagttct gtgccaaatc 3330241 aagaattcgt gtgttttcta caattttcga ggacaaggtg caaaaacatt ctgatatttc 3330301 gagcgaaaat ttcagcaagt gcaaaattct tttgcatatc ctctccgttt ttttataaaa 3330361 tagaagcaat attaagaaaa taattgaggg aggttcatac agtggtcaaa gacagcgaat 3330421 tcctcacatt ggtttttcag agtattttag atgaaatcga tgttggcctg cacgtggtag 3330481 acgagcatgg aaacacaatc gtttataaca ataaaatgat gcagattgaa gatatggaga 3330541 agcatgacgt cttgaataaa aacctgatgg atgtgtttat gttttcaaag cagcaggaca 3330601 gcacactggt acaggctctt caggaaggca agacgattaa aaacgtcaaa cagagctatt 3330661 tcaataataa aggccaggaa attacgacga tcaatcatac atatcccatc gtccaagacg 3330721 gcaaaatcag gggcgccgtt gaaattgcca aggatgtgac aaagctggaa cggctgatca 3330781 gggagaatat gaacaaaaaa ggcagcacaa cctatacgtt tgacagtatt ctcggcacca 3330841 gtccggccat tcaagacgtc atcgaaaacg ccaagcgggc aacccgtacg tcatcatctg 3330901 tccttctagc aggcgaaacc ggcacgggaa aagaactgtt cgcgcaaagt atccataatg 3330961 gaagcgatcg ttctggcggc ccgtttattt cgcaaaactg cgcggcactg ccagacagcc 3331021 ttgtggaaag cattttgttt gggacgaaaa aaggcgcgtt taccggcgct gtcgaccagc 3331081 ccggcctgtt tgaacaagcc cacggcggca cactgctgtt agatgaaatc aactcgctga 3331141 atctcagcct tcaggcgaag ctgctgcgcg cccttcaaga acggaaaatc aggcgcatcg 3331201 gttcaacaaa ggatacaccg attgacgtac gtattattgc cacgatgaat gaagacccaa 3331261 ttgatgcaat tgcaggcgaa cgaatgcgga aggacttgta ttacaggctg agtgtcgtca 3331321 cactgatcat cccgccgctt cgggaacgaa aagaagacat tttgcttctc gcgtcggagt 3331381 tcatccagaa aaacaaccat ctgttccaaa tgaatgttga acacatcagc gatgacgtga 3331441 agcaattttt cctttcttat gactggccgg gaaatattcg cgagcttgag catatgatcg 3331501 aaggcgcaat gaatttcatg acggacgagc aaacgattac ggcttcccat ctgccctatc 3331561 aataccgcat gaaaatcaag ccggctgaca tcccagagcc ggaaacacca agacaccagc 3331621 cagccgcgga cttaaaagaa aaaatggaaa gcttcgaaaa atatgtgata gagaacgtgt 3331681 taagaaaaca cggccataac atctcgaaag ctgctcagga gcttggcatc agcagacaaa 3331741 gcctccaata tcggctgaag aaattttctc actcgtctaa cgaataatcc ggagcaggaa 3331801 gcctgatcag aaaaacagtg cctctgccga tttcactttt cacttcaatc gtcccattgt 3331861 gattgtcgat aatcgatttc gttatggcaa ggcctaatcc cgaacctcca tatttccggg 3331921 agcgggatgg gtctgccttg taaaaccggt caaacactaa aaaacgtcac ttcttatgca 3331981 ttgaagaaag aaaatggcac ctatgtgtat cacagccagc aaccacacgg tacaaaccat 3332041 taaagtccat gcaaataacg gaagtatttg cagctaactg ccatttgctg tttcacgtgt 3332101 aacatccatc ttgtattttt cttcatattc gatatatcct ttttcaactg aacgggcgtg 3332161 acccctgttc agtttttttt gcatatcaaa acagcctggc aacgatgcca gactgctttt 3332221 attaactgcc taattggtct gcggaggaca gcttgatatc aacagatttt tcttttccgc 3332281 cgcgataaaa cttcaccttc acccggtcac cgactttttt ctgataaagc cgttttcgca 3332341 ggtcaacaat atcatttact ttgtatccgt caaattccgt gatgacatcc agttccttca 3332401 gccccgcttt tccggcaggt gaaaaggcgt ctacacccat cacaaccgct ccattggtga 3332461 cgttcttagg aagctttaat gtttcatccc aatgatagct tgcgatgtca cttagcgatt 3332521 tcatctcaat gccaaggaac gggcgtttga cctttccgta tctctctaaa tcctctatca 3332581 cagggatcac gagcttagac ggaatggaca ggccaatccc ttcaaccgct gactcggcaa 3332641 ttttcattga attgatgcca atgaccttcc catccatatt taacaaagcg ccgccgctgt 3332701 tcccagggtt aatggccgca tctgtttgca ggacttcagc gttccagtca ggctgtccat 3332761 caccgtttga atctactggg atcgccctct ccgtacccga gatgacgcct tgtgtgacag 3332821 agcctgcaaa ctcaaggcct aacgggttcc cgatcgcaat aaccggctcc ccagacttca 3332881 ctttatctga atttccgaaa tcagcgactg ctttaatctt atcgcttttc acccgtaaaa 3332941 cggcaaggtc catcagctgg tcgctgccga caagatcagc tgatacacgt gagccgtctt 3333001 tcaagctgat ttcaatttgg gaagcgcctt cgatgacatg atggttggtc acgacataag 3333061 cggaatggtc atttttctta tagatgacgc cagagccgct cccagcctcg ccgctctctc 3333121 cccaaatatc tgatttttgg atgttcacaa caccgacaac ggcgggcgac atattgctga 3333181 caatcttggt gacggcattg ttgacactga cattcaccgt cctgattgat tcccggccat 3333241 tgttgttttg ctgctgatct aaggcgcctg tatccagccc ttcatttgaa aggtacggca 3333301 tgataaacgc cattaatacg gcaccgacaa tcacgccaat cagactcgaa agaaaatatc 3333361 cttttttgct tctctttggc tgttcaggag tagtatgttc ttcctcacgt tcgtaatcca 3333421 ccatattcca tcctttccaa gaacgttaat atggttatat tgtgggttag aaactcctag 3333481 aatagtcatg atttacatag aaaaattata cagcgcaaag cggagtggcc ttcttcggat 3333541 cggtgtcgta taagtcaaat gtctcacccg tcacaaatcc tttagaagcc aatgtctgct 3333601 gcacagacat tcttgccagc tccttcatgt tgttgtcctg gctcaaatgc gccaggtaaa 3333661 tacgagacgt ctcatcgcca atgacatccg tcatcgccaa ggcagcatct tcatttgaca 3333721 cgtgcccgac gtcacttaaa atccgccgct taatgctcca tgggtatctt cccatttgca 3333781 gcataccgac atcgtgattg ctttcaaaca caaatacatt cgctgaacgg ataatgcctt 3333841 tcatccggtc gctgacatat cccgtatctg tcattaacgc gagctttcgg ccgctataat 3333901 ggaatacata aaacatcggt tccgccgcat cgtgggaaac gccaaacgat tcaacatcaa 3333961 gtccgccgaa cgacttcacc gtctccattg gaaatacaaa cttttgatcg gtgtcaattt 3334021 tgccgatttg attctccatc gctttccaag tcttctcatt cgcatagatc ggaagcttgt 3334081 actttctggc gacgacacca aggcccttaa tatggtcact atgctcatgc gtcacaaaaa 3334141 tgccgtctac atcatccagc ttacgcccga tctgcgccat cagcccatcc atggcttttc 3334201 cgctcaaacc ggcgtccact aaaaatgcgt gatcctctgt ttcgaggtaa aacgcatttc 3334261 ccgtactccc gctcgcaagt acgctaaatt gcaagctcat gtttgtctca ctccattatt 3334321 ttcattgatc tgtatctaaa atcgtactct ccaaagcatt cacagtaaaa tactcttgta 3334381 ctgtcttttt ctcaccgttc acttttttct cgtactcgac cgtaattctc cataccggcg 3334441 ccagcacctg cgtacttgtc agcggatatt gtgctacata gccgaattta cagctcttca 3334501 cagtgctgta ttcttttaat tgattttgat agtacaatag ctcaaccgca tccatttcag 3334561 taattaagct ttctttctgg atttgcttga aggtctcaag cgtagtctgg tcgtatgaca 3334621 caacctcgtt tttaccgttt aagtgcagca ccacttgccc gatcatatta gagggattgt 3334681 cggtcttttg gtaaatataa tgaccttcgt acgtttggaa gaaaataatt tctttcttcg 3334741 atttatcaac cttccaaagc ttatattttt cgccatcttg aattttcgaa gaaacaagtg 3334801 cctgagcatc gtcctcgata tccttctttg atagtgcgat tggatttgca aacttcattt 3334861 tcaggctcgt tactttatga tcatcactag gcatgtccat caaaggcttt tgatccttca 3334921 gcgcctcaat ttcctccttg gagaaagact tttgatttgc cgtgatccga tagccttctg 3334981 ttgcttcctt attcaagcct tcatacgtga tatgatcggc cttcatgtca tgctcgacat 3335041 catttttaat gacttcatat tctttgccgg tagcctgcca tttttgaaaa aactgatagc 3335101 ctaagaaaat atctaaaatg aggaaggcaa cgatgaagat tgattttgtc ttattccact 3335161 ccactgttag ccccctcctt cctcaataaa tcctttgtaa tcggcacaat ttttccattt 3335221 actttcatcg cccaaaccgg ttccagttca acgagaggat catcgttggt tgatgttgat 3335281 accaattgat aagcaaggaa gatctgatca attttgtccg tatcataagc ggtttgtttc 3335341 gaaagcagca tcttcacttc gctgccgccc atgagctctg tttcacttgt tttaatcgga 3335401 ttcgttccga gactgtaatt cggccgctta tagctgagaa tatcatcatt cgcccattgc 3335461 accgtaatcg ccgatgtcgc cccgaaaggt ttggcggtgc tgttaatgac cgggatctga 3335521 tccataaaaa tatagaagct caactgctgg ctgtcattga tattgaaaaa ttgatagtga 3335581 tccgtccagc ttccggtatc ctcaaggtat ttttggctct ttttgattaa ttcacctgtt 3335641 tgataggatg tgctctgcac caaattgcgc tgctgaaatt gcacctgtct ctggcttaga 3335701 ttcacatcta accggctgat cccatctgtc agcacatttc tgttggtgta attcgaatct 3335761 tctcttacaa tgctcggatc actaaacaaa gcctgcttaa aggtatttgt tttaatcgat 3335821 tctgtgacaa attctttttt gtccatcgta agcggtttgt tcggcagcaa gaactctttc 3335881 tttgagccaa tggagaacaa actgaacgcc ggcatatttg attgcctgtt tttcaagtcg 3335941 ttcataatgt tccggtagtt tgctgattca accgtcactt caagaatgag ctgcttgctg 3336001 tatgacacca aatagatttt cttgttcgct tttgtttcat tgaacgggat cagaatatgg 3336061 tcaaacgaac tgtattcaaa cgactgatta gaccatttaa acagcgtttg gaaaatatca 3336121 atcgggatcg tatcgctgaa ttgcaagtca agcttggctt cagaaccgcc tattccataa 3336181 aaccagcttt tgaatccagc cttgtcatac tgatccgaaa tatctttaat tcctttcaca 3336241 tcccaatgcg gcaagtcaga ccaaatttct tcatagaggg cattgtcatc cactttgtaa 3336301 tgagcgccgt catcatggat aaacatgtcc cttggcctta ccgtttcaga cagcttttgg 3336361 gtggtttttt cgattttatg tttcacacga acagtagact ctgttgagga tgagccttca 3336421 gaaaagtttg gctggaacgt ccatatcccc catgtaaaaa caagactgat gacgacgagt 3336481 accgtaagta atatcgtttt tatattttca cgcttcatcc caatcatcct cttgttcctc 3336541 tttatatgga agagtaaatg taatcgtcgt gccttttcct tctatgctgt ccgcccaaat 3336601 atctccaccg tgcgcctgta ccatttcctt ggcaatcgcc aatcccagac cggtgccgcc 3336661 aagctttctc gttctcgctt tatccaccct gtagaagcgg tcaaagactt tttcgacatc 3336721 ttttttcgga atgccgatcc cttcatcctt cacgctgata tagagaagtt cttcctcttc 3336781 attgacatca atcgagaacg tgacatgtcc gccttccggt gaatatttta aagcgttaga 3336841 aataatatta tcgagcacct gcgttatttt atcctggtca atctcgacat acagatctct 3336901 gtccggcaga ttgcggataa actccacatg ctgctctttt gtcatttcaa aacggtcaat 3336961 aataagtgac ataaaccgga caatctgaat ccattcccgg ttaaattgat aatctttact 3337021 gtcaaatttc gacagctgaa gcagatcatt gacaagccgg atcatacgct ctgtttcatt 3337081 ttgcgtcacc attaagaagc gcggagcaat gtctttattt tcccacgcgc cttcagctaa 3337141 cgcttctaaa tagctgcgca ttgtcgtaag cggcgtccgc agctcatgtg atacattcgc 3337201 aacgaattct ctgcgttcct gatccatttt ctcttgttcg gttacatcgt aaatgacagc 3337261 gattaaacca tcaattttgc cgtgttccct ttgaatcaca gagaaattca cgcgaagcac 3337321 cgttaattca tcatcgcgct caatttcaag cagcatagaa tcctgctgtt ccactaaatc 3337381 ttcaaaagta taattctctt gaagccccag caaactcgta atcggcattt ctaaggctgt 3337441 ttcacgtgaa acgttcaaca gttccagcgc cgggctgttt aagagaataa tcgctccgtt 3337501 tcggtttgtg gcgataacgc cgtctgtcat ataagcaatg acagaggcta gctttctgcg 3337561 ttctccttca gtcatcgcct gggcatcttc aagctctctc gttaagtggt taaacgttgt 3337621 ggccagctgc ccaatttcat catgtccata ctttttaacc ttcctcgaga aattcccttt 3337681 cgcaagctcc atcgcctgct ttcgcatatc tgaaagcggg tgggtaatgg ttcttgccag 3337741 aaaaataccg agaagagccg tcaaaacaag tgccaaacct gtgccggacg ccagtatcgt 3337801 gttgatcgtc ttcatttgat taaagacatc ttccatactc gcgacaacgt agatcgcgcc 3337861 cacaacctct tggttttcag tcatgacggg cttcgcggaa ataagaactc tgattttgct 3337921 tttcgggtca taatattttc ttaaatacga ctgtttggta gaaaagattc ttttgaaaat 3337981 cagatcggtc gtttgtttcc cagccacttc ctcaccgtac ggctttgaag aaccgaccac 3338041 ttcatagctt ttatctacaa agctaatttc ccgaacctca tcacttttcg tgaagtcatt 3338101 caaaatacgg ctgacgtcat cctttatgac ggtactgtcg ttatcgctct tatattcttg 3338161 ttcgatataa taagaaaggt tgtcgattcg ctgattcagc gattgttcat aagagctgat 3338221 cagcgacttc tctacctgat tgacaaaata cacaccaatg atttgcatgg caatgataat 3338281 caaaagcaca taaatcaagg taatcttaaa ttggatcgac cgaaaaaaac caaccttatt 3338341 catatgggca ttagtcctgt tctgggtttc tcaagtaata acctacacca cggcgtgtga 3338401 cgatccaatt tggatggctc gggttgtcct cgattttttc acgaagccgg cggactgtta 3338461 cgtcaaccgt tctgacatcg ccgaagtaat catagcccca aacggtttga agcaaatgtt 3338521 cacgggtcat cacttgtccg atatgttttg ctaaataatg aagcaattcg aactcacgat 3338581 gagtcaattc gattgtttcg tctcgttttg atacaacgta cgcgtcaggg aagatgacga 3338641 gagagccgat atgaatctcg ttagaggaag gctcttcctc cgcaggcgct gttgtcagct 3338701 ggcggcgcag gttcgctttt acacgcgcca agagctcgcg tgtgctgaat ggttttgtga 3338761 catagtcatc agcaccgatt tcaagcccga taaccttgtc aatttctgaa tccttagccg 3338821 tcagcataat gattggcata tcgtatttct ttctgacttc gcggcatact tcaacgccgt 3338881 ctttatttgg gagcataata tctaaaagaa ttaaatcagg ctgaagctct tctaccattt 3338941 caacggcttc gtttccgtcg tgggcacagt gcacttcata gccttctttt cttaagttaa 3339001 attccaatat atctgcaatc ggtttttcat catctactac aaggatcttt ttatccatca 3339061 ttttgatttt cctcctgccg aatgacttca tttcatctat ataacattcg tttcatcact 3339121 tatggcccat gtaaagaatg ggtccttgtc tattataacg gtttaaggtc aaaagataaa 3339181 aaaaataaag gtttagaaaa aaaacacatg tttcaccttt atcgccagtt gtttatctat 3339241 tgtcatgctg gtcaactttt tttaaaaaag ataactttat tgaaacctcc cctcaccgga 3339301 gtgcgtcttt atcaatgacg tcttcttctt tgaaccggcc gcagggccgg ttctcccttt 3339361 ttcttctatt ataacactcc tcatgtttgc ctttttccta aaagaaaaaa cgcacctacg 3339421 attgcagatg cgtttggtaa gtggctcggg acggaatcga accgccgaca cacggatttt 3339481 cagtccgttg ctctaccaac tgagctaccg agccaaatgt tttatttttc tctactaagt 3339541 aaagtaaaat ggcggtccgg acgggactcg aacccgcgac ctcctgcgtg acaggcaggc 3339601 attctaacca actgaactac cggaccttac agtaattgcc cggagagctg tcgtgtcagc 3339661 tctcacagac aaataaggaa tttagcaata acgctaaagt aaatcaatga cccgtacggg 3339721 attcgaaccc gtgttaccgc cgtgaaaggg cggtgtctta accgcttgac caacgggcct 3339781 tcacgaaatg gtgagccatg aaggactcga accttcgacc ctctgattaa aagtcagatg 3339841 ctctaccaac tgagctaatg gctcttaaag atgtcggaat ttctatagag caaacgactt 3339901 aaatctagtt ctcatcttgt actctattga agcagtttcc gtaacaacga gatttataat 3339961 atcacgaaca aatagaagtg gcaataactt ttttggtttt ttttcatatt tttttctcag 3340021 accaacttat atgcggcttt caaacaaaaa acaagcccct taaatagggg cttgcagaca 3340081 tattctattt agttcgcacg gtacacactg cgaaggacat ttgtttgtga gcggtctgga 3340141 ccgacagaga aaatagaaag cggaatgcct gtcagctgag acacacgctc aagataatgg 3340201 cgcgcatttt ccggaagctc gctcaagctc ttcgcacctg taatatcctc agtccagccc 3340261 ggcatttctt catataccgg ctcacattca gcaagtgcct taagacttgc tgggaattct 3340321 tcaatgattt cgcctttgta gcggtacgcc acacagattt tcaacgtttc aattcctgct 3340381 aggacgtcaa ttgagttcag agaaagatct gtaattccgc tcacacggcg ggcgtggcgg 3340441 acaacaacgc tgtcaaacca gccgacacgg cgcgggcggc ctgttgttgt tccatattcg 3340501 cgtccgactt cacggatttg atcgccgatt tcatctttca gctcagtcgg aaaaggaccg 3340561 tcgccgacac gagtcgtata tgcttttgat acaccgacaa cgtgcttgat tttggtcggg 3340621 ccgacaccag aaccgatcgt gacaccgccg gcaaccgggt tagatgacgt aacaaacggg 3340681 tatgttcctt ggtcgatatc gagcataacc ccttgtgcgc cttcaaataa tacacggcgc 3340741 ccttcatcaa gagcatcgtt taagacaaca gatgtatcgc aaacatactt tttaatctgc 3340801 tgtccgtact cataatattc gtctaagata tcctcaagtt taaacccttc tgtctcgtac 3340861 attttctcga gaagacggtt tttttcttca agattgcgct caagcttttc cgcaaacgcg 3340921 tcacggtcta acagatccgc gatgcgaatt ccgatgcggg ctgctttatc catgtaagca 3340981 gggccgattc cttttttcgt tgtgccgatc ttgttagccc ctttacgctc ttcttccact 3341041 tcatccaatt tcaaatgata cggcagaatg acgtgagctc tgttgctgat tctcaggtta 3341101 tctgtactca cgttgcgctc atgaagatac gcaagctctg tgactaatgc tttcggatct 3341161 acaaccattc cgtttccgat tacacacgtt ttatccttat agaaaattcc agacgggatt 3341221 aagtgaagct tatatgtgat tccgtcaaac ttgattgtat gccctgcgtt atttccgcct 3341281 tgataacggg cgatcacttc tgcattttct gataggaaat ctgtaatttt accttttcct 3341341 tcatcgcccc attgcgtacc tactacaact actgaagaca tgtccgtgca cctccgttaa 3341401 cctttcaaaa cgattctatt caaacaaatc aagtttatca gtgaagaaac agaaagtcaa 3341461 ttgtaaatcc gaacattaat ttattgtaaa tctatattcg ttcgcttcca ttcgttttat 3341521 aagcgttttc tcactgcttt gtcataaaaa gcttgcgaaa ctttcatcct ttagcataag 3341581 aaagaatcac ttgcctgata tcccttttga attcataaaa acgatccgcc agccgtccgg 3341641 gtcctctatc gtcacgcccc cattgctcca gtacgggttc tctgattcga cctcttgata 3341701 gcccatgtgc tttagctttg aagtgatcgc tgccagttca actgcattcg gcacataaaa 3341761 aacaagaagg ctgtcgggat ggggaacggg ggcagtgctt cccccttcat actgggtgaa 3341821 ttccaaatga taatcggcat gaggaaggcc gaacatgaca ccgtcatacc cgttatgctg 3341881 tgaaaattct cctattcgtt tcaaacacag tccctcttcg taaaaacgaa taatctcatc 3341941 aagctggccc gtaggacgcg caattcggat ttgtgctgct tgaaaagacg aaaaacgttt 3342001 tcccatattg ttaccatctc ctttttgcac cattttatta aaacgctttc aatttttcat 3342061 ccgctgagcg aacgtcattt cttccatctt tcgaatgaaa aaaaccccaa gagcagctct 3342121 tggggcttat gcgccgggcg gaacgcctgc gtcatcaaaa cgccgttcca ggttgacgaa 3342181 tttgttgtat tcttttacga acgcaagaga cacggttcct accgggccgt tacgctgttt 3342241 ggcgataata atttcgataa tatttttatt ctcggtttct ttgtcatagt agtcatcacg 3342301 ataaaggaac gcgacaatat ccgcgtcctg ctcgatactt cctgattccc ggatatcaga 3342361 catcatcgga cgtttatcct gacgctgctc aacacccctg gaaagctgag aaagcgcgat 3342421 aacagggact tgcagctccc tcgcaatcga cttcagttca cgggaaattt cagatacttc 3342481 ctgctgacgg ttgtcctttg aacgaccgct tccctgaatc aattgcaggt aatcgatcaa 3342541 aatcatgccc agcccgcttt cctgcttcaa gcggcggcac ttggcacgga tttcactcac 3342601 tcgaataccc ggtgtatcat cgatgtaaat cccgctgttc gataggcttc ccattgccat 3342661 cgtcagcttg ccccaatcct cttcggtcag gttacctgta cggagattct gggcattgat 3342721 atttccctcg gcacagagca tacgcataac gagctgctcg gcacccatct caagactgaa 3342781 aatcgctacg ctctcatcgg tcttcgtcgc cacgttttgt gcgatgttca gggcaaaggc 3342841 tgttttccct actgaaggac gggcagccac aatgatcaag tcgttgcgct ggaaacccgc 3342901 agtcatccgg tcaagctccg taaaccctgt tggaattccc gtgatatcac cttttcgatt 3342961 gtgaagctgt tcgatattat cataggtctg gacaaggacg tccttaatat tttggaaggc 3343021 actcgtgttt ttgcgctgtg ccacttccat aatcgttttt tccgcttcac tgagtaaatc 3343081 ctcgacctca tcctcacggg tatacccgtc ttgagcaatc gttgtcgcag ttctgattaa 3343141 tcggcgaaga atcgattttt cctcaacgat tttcgcgtaa tattctatgt tagccgctgt 3343201 cggcaccgag tttgcgatat ctgtcaaata tgaaataccg cctacttctt ccagcaggtc 3343261 tgtgttcgca agctctgatg taactgtcac cagatcaacc ggttcacctc ggtcaccgag 3343321 caccagcatc gcattataga ttttttggtg ggacattcta tagaaatcat ctggaatcaa 3343381 tacttctgaa gccagtgtta aagcagacgg ctgtaaaaaa atagcgccta acacggcttg 3343441 ttcggcttct atattttgcg gaggaagccg gtcattcaga aggtctgtca tgctaagcac 3343501 cgtcctctca ttaaaaaatc tccaacctcc attctaccat ttctacagaa aaaaaataga 3343561 aaaattgtct gtttcctgtt tttttcagtt agcagattgg atcgtttcgg acagtaacaa 3343621 ggcgggaaaa atgcaataaa acataaggga ggaatgaaag atgataaaga aatatgcgat 3343681 tacacctaat gttgatgcgg acggctggtt tattgaggtg gagaatgtag cgccgacagc 3343741 tttgtatacg tctaaagacg ccgctattga aaaggccaaa caggtggcta aggaaaacag 3343801 tccgtctaag cttgtaattt atgaccagtt taaaaatgtg gaagaagaac actcatttta 3343861 atgaatgaaa gccttcgctg cagcgagggt tttttagcgg ttatcggttt atttcatcca 3343921 ttggatgcct atgtgcatca tcaaatctgc cgctttttga tacagatccc actccccgat 3343981 cgaagcaaat ttccccatca gctcctgaag ctttaacctc attgctatat attcttcgaa 3344041 agtgacagct ttttcagtgt ctatttggtg ttccttcagc atttgtttta ataaggataa 3344101 cggtgcgtgc ataagaaccc tccttacctc ttttataacg gtcattttcc gattgctcta 3344161 ttcctttgtg acatcttctt acatttcaca tctgattctt gtacaatgga cagaagagag 3344221 gagggatctt ttgtgagacc tttgcaaatt tctgccgaaa ctgcacaaaa gcttgcagag 3344281 tccttgaatc tgccgcttga acagatcatg catatgcctc agcatattct gcttgccaaa 3344341 atggctgaac tgcaaaaaga ggacaaatca tagccttcat tcacatactt gcttacctgt 3344401 ttcgggataa tatcatgtat atgttagaaa agaggagtaa ctgctttgcc acatccacat 3344461 aataaaaaaa tccaatcatt ttggctgatc accggcatta tctttatcgc ctttaactta 3344521 cggcccgcga tcacttcagt cggtccggtc atcagctcta tccgggcaga gctgcacatg 3344581 tccaatgggg cagccggttt tttgaccgca ctgccgctgc tttcgtttgc agttctttct 3344641 ccgcttgcac ctaagcttgg acagcgcctc ggtaatgagc gaactttatg gctaggtctc 3344701 gtgatactgc tgatcggtgt tctgactcgt tctaccggct atactgccgc tttgtttttc 3344761 ggaacagcac ttatcggcgt cgggattgcg attggtaacg tacttttgcc aagcttaatc 3344821 aaacataaat accctgaaaa gccagggatc atgatcagcc tgtatacgac atcaatgaat 3344881 atattcgcag ctttagcatc gggtgtcagc gttcctttag cgacccagat gaatggcgga 3344941 tggaaacaag cctttctctt atggggcggg ctggctttac ttgcattgct aatctggata 3345001 cctcagctgc gccatcgaga tacggcaaac cagacaatga agctgcaatc cagttccatt 3345061 tgggcttcca aaatggcatg gtatgtcacc atctttatgg gcctgcaatc gtttttattt 3345121 tacagcagca tcgcttggtt tcctgaaatt ctccgttcac acgggattga tacggcaaca 3345181 gccggatgga tggtatcact catgcaattt gcgagtctgc cttccacttt tctgacgcca 3345241 gttttagctg accgtgtgaa acagcagcgc ggtatcgttg cggcgctggc ctcagtttat 3345301 ctgatcggcc tttgcggatt attagcgggc ggaagccata cattgcttgc catctggatg 3345361 atcattatcg gtatcggaca aggctccagc attagtctgg cccttacttt gattggtctc 3345421 cgcagtgaaa atgcccaaca ggccgctgcg ctgtcaggca tgtctcagtc attcggctac 3345481 ctgctggcag cagtcgggcc aatctttgtc ggctatctct ttgaccagac gcattcttgg 3345541 acgatgccga ttgtgcttct cattgctgcc ctgatcgtaa tgggagcagc cggacaggga 3345601 gccggacgag atcgatacat tttccagtca gaaaaacaaa gaaattcagc ataaagcggg 3345661 gaagatatct ccgctttttt ctttgaatat ttatggttta ttcataagtt tttcatattt 3345721 gttttttaca atgagacacc ataaagaggt gaaaaacgat gaaaaccaaa cgattcgacg 3345781 cagcccttat tcttattttg ctagcagcag cttttttgaa tacgtatcac atttggcagg 3345841 atgatacagc aaaccagtac tatttggcgg ctgtaaaaag catgacgcaa agcttccata 3345901 acttttttta tgcgtcattt gacccttctg gatttgtgac agtagataag cctcctgtcg 3345961 tgttatggat tcaaacgatt ttcgcactga ttttcggtgt tcacacgtgg agtgtcatca 3346021 ttccccaggc tcttgccgga gttggatctg tcttccttct ctacagaatg gttaagccga 3346081 cttttggagt tggagcggcc cgcattgccg cacttgtcat ggcactgacc cctatcgcag 3346141 tagctgtcag ccggacaaac aatatcgaca gcatgcttgt ttttacctta ttgctcggtt 3346201 caacttgtct gcttagggca gtaaaacaag gcaagctggt ttggctgctg acggcatttg 3346261 ccctgattgg gctcgccttt aatatgaaga tgatgcaagc gtttatggta ttgcctgcat 3346321 ttgtgttatt ctacctgatt gcatctcggg tttctctgaa gaaaaaaatc gggtccctgc 3346381 ttctgtctct tgtccttctg acaggccttt cactctcatg ggcgattgca gtggattcag 3346441 cctcttcctc aagccggcct tatgtaggaa gcagccagac taactcagtg ctagaactgg 3346501 cctttggcta caacggcaca gagcgtctgt ttgggcaaac tacgggcctt gcaaagggtg 3346561 atatgaatgc tgctggcgga gggaacatgc agaatcaaga caacatgcaa gcgccaaatg 3346621 gcaacggttc atctttttct cagaacggta atcaatcatt cggaaaccat tcacaggcgc 3346681 ctcagccgcc taacggacaa accggcgctc tcaatggagg cggaggcaca cctcccacag 3346741 gtggcaacgg acctggaaat ggagggcctg gcggcggagg cggaaaaagc gtgaatatgt 3346801 tcggcaccgg tgatcctgga ccgcttcgtc tcttccaatc agcactttcc ggccaaatca 3346861 gctggatgct tccattctca ttgatcggat tactgggcgc aatcatcagc tggtaccgtg 3346921 atcgccgcgg acatgctgct aaaatgaaag aaacgctatt ctgggcggct tggcttgttc 3346981 ccgtggctgg tttcttcagc atcgcaggat tcttccacca gtattatttg attatgctgg 3347041 caccgccgat tgccgccctt tctggtatcg gatggtatac gatgcaccgc ttatacaaaa 3347101 ataataaaga ctggtccagc tatcttctgc cggcagccgt cttgatcaca gccgtgtttc 3347161 aggtgtatat tctgagcgct tatacaagcc aaatcggcag tgtatggatg tatgtcctgg 3347221 ggctcttagg actgggcatc acccttgcac ttctgatgct taaacgcagc catccgttca 3347281 gtaagctgct gaccatcatc agcttgtgcg ttctgcttct cacaccagtt tactggtcag 3347341 caacgccgct tctatacggt ggcaacagcg tccttcctga atccggcccg cagctcaaag 3347401 gctcagcaaa cggcgggaac atgttctctt cagaggtcga cagcgggctc ctgtcctatc 3347461 tgagaaaaca caataccggc gaagagtatt tatttgctac tttgacaacc gtaacagctg 3347521 cgccatacat catttacgaa aatgaatctg ttatggcaat gggcgggttt aacggcacgg 3347581 atcccattct gactgtgtcg gaactgaaaa aactgatcaa agaaggcaaa gtgaaatact 3347641 tccttctgtc agaaaacaac tcaggcaaca gcgaacttgt ttcctggatt aagaaaaacg 3347701 gaaaagaaat aacatctgac gagtacagcg gttcctccag cagcacaaac agcgtgcagg 3347761 gaatgcgaag aggacctggc ggagaaagcc agcaaactct ttatctcgtg gaataaaaaa 3347821 agaggcttgg atgaatccaa gcctcttttc tattaagctt cttcttttac atgtaccttt 3347881 aacacagcct gcacttcagg atgcagcttc acaggcacgt ttgtatatcc taatgcacga 3347941 atgccgtccg gcagttcaag cttccgctta tctactttaa tgttatggtc tttttggagc 3348001 tgttcagtga tttgcttgct tgtcactgaa ccaaataaac ggccgccctc acctgatttt 3348061 gcgctaagct caacagtcag tttttctaat gtctctttca agctcttagc ctgctcaagc 3348121 tcagcaatgg cttctttttt ctctttctgc ttttgtccgt ttaacgcgct gatgtttgac 3348181 gcgttcgctt caaccgcgag gcctttttta attagaaagt tatgcgcata accgtctgct 3348241 acgtttttga cttcgccttt ttttcctttt ccttttacat cttgtaagaa aataaccttc 3348301 atctctgtac gcctccctca aaatactcat ctatggcgtg cttcagccgt tccagcgctt 3348361 cagaaactga aatgccggac aactgagtcg ccgcatttgt taaatgccct ccgccttcca 3348421 gggcctccat gatgatctga acatttacct cgccaagcga ccgagcactg atacaaaccg 3348481 tttgttcatc ccgtctcgcc accgcaaatg aagcctcaac ctcactcatc gatagcagcg 3348541 aatcggcagc ctgcgcaatc agcacttgat cgaagtattc ctcttcattt tcaggaagag 3348601 aagcaatcgc aatgttatct ttatagagga ccgtatgctg gatcagcttc gcccgtttaa 3348661 tataggaatc aacggtttct ttcagaaact tctgcaccag caccgtgtcg gcgccttttg 3348721 cccttaaata agaagccgca tcgaaagtcc gcgagcccgt gcggagagaa aagctctttg 3348781 tatccactat tataccagct aatagggctg ttgcttcaat catattgatt tttaagcgct 3348841 tcggctgata ttcaagcagc tctgtcacca attccgctgt ggaagaagcg tatggttcca 3348901 tataaacgag cagcggatct ctgataaact cctcacctct tcggtgatgg tcgatgacca 3348961 cgatatgttc aattttattg accagccgtt cctccatgac gagtgacggc ttatgtgtat 3349021 caacgatcac aagcagtgtg tcatcattgg aaatctccat tgcttcttca ggcgtaataa 3349081 atcttgacca cagttcttca tattttttga tttccccaat caaacgctgc acacttgatc 3349141 cgatttggtt tgggtcaatc acgataaaac catctttgtt atttgcctga gccaccttta 3349201 aaatcccgat cgctgcgccg atagaatcca tgtcggggaa tttatgcccc atgataatca 3349261 cattgctgct ttcggtgacg atttccttta aggcgtgaga aatcacgcgg gcccgcaccc 3349321 ttgttcgttt ctccattggg tttgttttac cgccgtaaaa cttcaccttg ccgtttggca 3349381 gcttaatggc tacctggtct ccgccgcgtc ccagtgctaa gtccaagctg gattgcgcca 3349441 aatcgccaag ttctttcagg gaagagactg aagccccgac accgacgctt aacgtcagcg 3349501 ctacaccgtc aaacgaggtt ttttcccgca cttcatcaag aatcgaaaac ttcgaatttt 3349561 cgagttcagt taagatatgt tcattaagta cagcaataaa gcgttctgaa gacgtccttt 3349621 tcaagaagat cccgtactcc tgcgcccaag cgttcagcaa agatgtcacc tggctgttca 3349681 tcgtgcttct cgtctggtca tccaatcctt gtgtcacatc atcatagtta tcaaggaaaa 3349741 tatatgccag gacggttctt tcgttttcat atagcttttc aatctggatt tgttctgtta 3349801 catcaaagaa atataagaga cgctcatccc gtttgatgac aaccctaaac ttgcggtcat 3349861 tcaatgtaac cgtttccgat tccacctctt gtttgataag cggcactacc gattcacaag 3349921 tatcgtaaag tgatctcccc actaaagtgc tttcattaaa acaagaggaa agaaacggat 3349981 ttgcccattc tatataatat tggtcattaa aaagcatgat tccaatcggc atttccatca 3350041 atgcctcttc accgactttt ttcaacctgt aggacaacgt agaaatataa gcatcaatct 3350101 cttgtcgaat aagagaatca gcacgcttaa taaaaaacaa aataactgcc agcagcagca 3350161 cttcgacggt tcctaatatc cagttaaaat aaaagctgat gaggattgta ataattgaca 3350221 gagcaatcaa tgcatagatg ggataccgaa acagcggttt ttcataaaag cttggcattt 3350281 ctatcactcc ccaccatgtg agtaaaactc atgttcactt caccttattc cttatatgaa 3350341 agcccatatc taaaacgcct aaaatgcgaa tggccgccat gaagaccgga tgcacaaacc 3350401 caagtatgac agcaatcaca gccgcagcct ttggatattg tttcttatgg caatagaaaa 3350461 agataaatga taaaccttgg atgaaaatca gaaacccgag tataaactcc ccatttaaag 3350521 cgatagagta cagcatttgg cctttttcta aaggcaaaaa tgaaagcatg acaataatca 3350581 aatacagtac tacaacactt tgcggaaact tcaactctct aaaaggcttt agattaggaa 3350641 tatcggggga gaatcgcctt aagagcggct tagcgataag gtaactgagg aaagaaaaaa 3350701 taactcctac catcacaata gctgttggaa aaagatattg aacgataccc aattgttctt 3350761 ccatcagttt taattgcttc tcaaactgcc cagcattgcc cgactgcttc gctacagttt 3350821 ctacaatatc aagagattgc cggtattgtg tcattgcctc atcaatgata ttgataccca 3350881 aaaactgaat gcttatcaca aaatagaaga caatactaag catataaata agagcgcccg 3350941 aaataatggc gtgcccgggc tctttccttt tgaaaaaatg tcccatggca atgccggcgc 3351001 aagctgacat aaaagctaca ataagcccgt taaaggaccc gacaataaaa acaaccggaa 3351061 gactgacagc gcccatccat atccctagct tcaatccatg tctgatcgta tacaagatca 3351121 ttggcagcgg cagtgcaaat aacagaattg ttccaatcac aggaacataa acgaccagaa 3351181 gcgtaatgat cgcaaacaga ctgattaaaa tagcaccttc cattaaagct ctcgtttgtt 3351241 tcacttagtc acctcgtatc atcctgaaca tacgaataga aaagagcagc ataaacgact 3351301 gctcttttgt tcatcgctgc aacatgcttt gcaccgaatg tttttatatc atctctaaat 3351361 tttactttta tattttaaca taagtccaaa tcgcaagtaa aatgacgcta atgtttcatg 3351421 tgaaacatga aaaaggaaaa gacattcttt gaaaagaatg cccatcacaa ttaatgttta 3351481 tcatccataa agccagaaga ttccttgttt ttctttttcg tttttctgac atacataaaa 3351541 attaagatca ccagtaaaag ggttgttgct tgcagaacgc cgctgctaaa caagaaaaag 3351601 ttctttatca tgtcccacat tgtgtttcac ctctttgtgc atgttctcaa cccgtatcct 3351661 atataaggtg aatttccctt tttaaaaact tcaaaacatc atgaacaaca ttgagcgttg 3351721 ggcatatgct gatatggaat ctgatcgata aaggagaatt ttcacatgga tgaacgcaga 3351781 acattggctt ggcatgaaac attagaaatg cacgagctgg ttgcttttca atcaaacgga 3351841 ctcattaaac tgaagaaaat gataagagaa gtaaaagacc ctcagctcag acagctttat 3351901 aacgtgtcta ttcagggtgt tgagcaaaat ttgagagagc ttcttccgtt ctttccacag 3351961 gctccgcaca gagaggatga ggaagaagaa cgcgcagata acccatttta cagcggtgac 3352021 ctgctcggtt ttgccaaaac atctgtccgc agctatgcca tcgcaattac agaaacagca 3352081 acacctcaat taagaaacgt actggtcaaa cagctgaatg ctgccatcca gctgcacgcc 3352141 caagtttatc gatacatgta tcagcatgga tattatccgt cttacaacct ttctgaactg 3352201 ttgaaaaacg atgtcagaaa cgccaacaga gccatttcaa tgaaataaaa caagcagcaa 3352261 aggagttccc tttgctgcta tttctgctga tccttcacta agccgttcga acgataagat 3352321 tccagcacgt ctctgttgga ttctccccat tctttcattt gcaaaacaat cggttcaagc 3352381 gtgcgcccaa attccgtcag agagtactct accttgggcg gcacctggtg ataaacctca 3352441 cggtgcacga tgccgtccgc ttccagctcc ctcagctgga gagtaagcat tctttgagta 3352501 atactcgggc agattcgccg aaactcatta aatcgtttct tgccatctat catgtgataa 3352561 aaaagaattc ctttccactt tccgccaatg acatctagag tgaattcaac tggacagcct 3352621 tctttgttcg ggtatatatt ctttttttca ctcattcttg accctccaat agtacctttt 3352681 ttgatactac attacatttt gcaactaatc tacccagtat tttacacacc ttttctcctt 3352741 agctcaaaga aaatgcttct tattcacatc aatttttaag ggtttgcatg attacacctg 3352801 cagcaagacg tgttaaacta tataaagatt acactactta aaaaaggata ggagctatca 3352861 tggaaaagat acttattttc ggacaccaaa acccagatac agatacgatt tgttctgcga 3352921 ttgcttatgc tgatttgaaa aacaaactcg gcttcaatgc tgagcctgtc cgcctcggac 3352981 aagtcaacgg cgaaacacaa tacgcgcttg actatttcaa acaagaaagc ccgcgtcttg 3353041 ttgaaacagc tgcaaacgaa gtaaacggcg ttatcctggt tgaccataac gaacgccagc 3353101 aaagcatcaa agacattgaa gaggttcagg ttttagaggt tatcgaccat caccgcatcg 3353161 ctaactttga aacagctgag ccgctttact atcgtgctga gcctgtaggc tgtacggcta 3353221 ccatcttaaa caaaatgtac aaagagaata acgtgaaaat cgagaaagaa attgccggcc 3353281 ttatgctgtc tgcgatcatt tctgattccc tgttatttaa atctccaact tgcacggacc 3353341 aagacgtagc agcagcaaaa gagcttgcgg agatcgctgg agtagatgct gaagaatacg 3353401 gcttgaacat gttgaaagca ggcgctgatc taagcaaaaa aacagtggaa gagctcattt 3353461 ctcttgatgc gaaagaattt acactcggca gcaagaaagt cgaaatcgca caagtaaaca 3353521 cagtggacat tgaagatgta aaaaaacgcc aagctgaatt agaagctgtg atctcaaaag 3353581 ttgtggctga gaagaatctt gatctgttcc ttctcgttat cacagatatc ttagaaaatg 3353641 attcacttgc tcttgcaatc ggtaacgaag cagcgaaagt ggaaaaagcg ttcaacgtta 3353701 cattagaaaa caacacagcc ctcttaaaag gcgttgtttc ccgtaaaaaa caagtcgttc 3353761 ctgtcttaac agacgcaatg gctgaataag ccattacaat tgcttcaaaa tccttgcggg 3353821 gtttccgcct acaacagtat tagcgggtac atccttagtg acaacagatc cagaagcaat 3353881 cactgcgtta tcaccgattg tcactcccgg gttaatcacc gcccggcctc caatccaaac 3353941 ttgatctcca attgtcacag gcttaccgaa ctccttcccg gatttccttt cgatcggatc 3354001 aagaggatga ccggccgtgt agatatgtac acctggcgca atcaaacaat gacagccgat 3354061 acgcacctca cacacatcta aaatgacaca gtcaaaatta acaaatgtat gatctccgat 3354121 atgaatgtga tagccataat cacagcggaa tgtcggcaaa atcgtgactt gatccccaac 3354181 cgaaccgagc agctccttca aaagcttcgt ccgcactgca tcatcttccg gtgtttcgtt 3354241 gtattgtcta atcagctgtc tcgcatgctt gcgttctagt aatagttgtt gatcttccga 3354301 attgtataat tctccggctg ccattttttc tttttctgtc ctcagcattt aagtcactcc 3354361 agatgtcaga ttgtaatctc gatcaaattt ccttcatcat cctcaatcac gctttcatag 3354421 tagccgtctc ctgttgtcct cgggccgttt actactgcga aaccatccgc cttcaatcga 3354481 tcagtcagtt cgtcaacttt ctcccggctc ccaacggaaa aggcaatatg tgcccagcct 3354541 gtcattgttt gtgagggcgg atcggtcaca ttcccttttt tcataatttc cagccttgct 3354601 ccggaatcaa acgtaataaa ataagactta aaatcttttt tctcattatg atacaaatca 3354661 ttcgcttcgc cattaaaata cgattcataa aaagacttca ttcgctctaa atcattgacc 3354721 cagaccgctg tatgttcaat ctgcatttct tcctcctcct tcgccttcaa tgaagttata 3354781 aggtatgaaa tgcatttcag ttcaagcttt tttcttaaat ttatgctgaa ttttgatatc 3354841 agcgggttca tcctgcaaaa atagagaaaa tgctgcgatg ccgagctgct caagattcaa 3354901 atcaagcgac ggaaaaccaa gaacacggct gatagaagta tttccctcgc ctatgatttc 3354961 aacatcccaa ttattctttt tggcaaatag atgaattcca gctgccactt catcactatt 3355021 tgcataaata gcagtcggaa cccgcccgct catataaaaa tgttcagctg ccagctcacc 3355081 atcattcata tcgttgcatc cggacagcat atggcggtct tccaaccttc cgcagacagc 3355141 tttataggcc gcagctttat cagccgtgct cgggctccta tcagcttctc tgacacacgt 3355201 aaaagcaata ttctcatgcc cgcggctctt taaatagcga aagctctctg cataagcagt 3355261 ttttctgtca ttaaaagcac aagggacatc aatgtctccg gtatcctcac aagcgatgac 3355321 cggcccatat tcctgataag ctaaaatgct gtcccaatga ttggcgcggg aagtaatgat 3355381 gagaccgtct attttcttcg ttcttaacag ctctaaatat ttgatttcaa tatcggggtt 3355441 ataattggtg gggagaaggg tcgttgcata ctcatgctga aaagccgcct tggtgattcc 3355501 gttaacgatt ttatcaaagc agggatgatc gctataaggc agaatcacac cgaccgtatg 3355561 ggttttcccg cgaatgagat cgattgcggt tcgatttggt gtataatcca attccttcat 3355621 gacttgatga acaagctttc tcttttcttc agatacatac ggatgatgat tcaatacacg 3355681 cgagacagtc gaaacagata catttgccag tcttgcgatc tcttttatat ttgccatctc 3355741 tttctccttt tcatataaaa aaagcagtaa gtgtaaaatc cttactgcta tctcatcata 3355801 tattgatgat aagttcaaca ggacaatggt cggaacccat gacgtccgct gatatgctgg 3355861 catcttcaat ctgttcctta aggctttcag aaacaacaaa ataatcaatc cgccatccaa 3355921 tatttctgtc ccgggcgccg gcacgatacg accaccagga ataagcgcct tcaagatcag 3355981 gataaacatg acgaaaagaa tcaacaaagc cagcttctaa gaaacgagtg aatgcctctc 3356041 tttcttgatc tgaaaatcca gcgttattcc ggttcgcctt tggatttttc aagtcaatct 3356101 cctgatgggc tacattcaaa tcaccgcata aaatcactgg ttttttctga tccaattcaa 3356161 gaatataaga cagtaaagcc tcttcccatt gcatgcggta atcaatccgc tctaatcccc 3356221 ttctggaatt gggcgtgtaa acagtcatca caaacacgtt ttcaaattcc agcgtaatca 3356281 ctctgccttc ttggtcatgc tcttctactc cgataccgta gatgacctgc agcggttctt 3356341 gcttagaaaa aacagctgtg ccggaatatc cttttttcac tgcataattc cagtacacat 3356401 gatagtcttc aggctggaga tcaacctggc cgtcctgtat cttcgtttcc tgaagacata 3356461 taatatctgc atcctcttct ttcaaataag agaggaaatc catttttctc atcacagccc 3356521 gcaggccgtt tacattccat gaaatcaact tcatgtttca tcctcccccc tataaaaaag 3356581 agcaagaacc cgaaggtcct tgctctttac atatcagctt actcaccgct tacgtatgga 3356641 agtaaagcca tttgacgtgc gcgtttgatc gctgcagtca atttacgttg gtatttagcg 3356701 tttgttccag ttacacgacg tggtaaaatt ttaccgcgct cagaaacaaa ctttttaaga 3356761 agatctacat ctttgtagtc gatgtgcgtg ataccgttag aagtgaaata acacacttta 3356821 cggcgtttcg cacgaccgcc tctgcgtcct cctgccattg tcatttccct cctttctttt 3356881 tcattttagg cgataatcac attagaatgg aagatcatca tccgagatgt caatcggttt 3356941 gccgtcgttg gcaaatgggt catcattaaa gctgttcccc tgattgcgtc tctggttgtt 3357001 ttgatttccc ccaaatggat tatcattttg gcctccgcca aagtactggc ctccgccgct 3357061 gtttccttcg ttgtatccac ctgaaccaga accgccgccg tttttcggct caagaaattg 3357121 aacactttca gcttggacct ctgtcacgaa gacacgctgt ccttgctggt tttcatagtt 3357181 tcttgtttgt aaacggccat ctacgcctgc aaggcttcct tttttcaaga agtttgcaac 3357241 gttttcggct tgtcttctcc aagtgacaca attaatgaaa tcggcctcac gttctccgga 3357301 ctggttcgta aatgtacgat tcacagcaag agtaaacgta gcaacagccg caccgtttgg 3357361 cgtataacga agctctgggt cttttgtcag tcttccgact aatacaactc ggttaagcat 3357421 aagaaagacc accttttacc attatatatt tcaaaattgc ttattcttct tctttaacaa 3357481 caatgtggcg aatgatatcg tcactgatct tagctagacg gtcaaattct tgaactgccg 3357541 cagcgtcaga ttgaacgttt acgatttggt agaaaccgtc gcggaaatcg ttgatttcgt 3357601 aagcaagacg acgtttaccc caatcctttg ttccagtgat ctccgcaccg ttagaagtca 3357661 gaacgttgtt gaaacgctcg ataactgctt ttttagactc ttcgtcaatg tttgggcgga 3357721 taatgtacat aacttcgtac tttctcatct gtttgcacct ccttttggac taagcggccc 3357781 ataatgggca aggagcaata attctattac tcacaatttt atattatacc aaagctcttg 3357841 tccctttaca actgcatcct atacattaaa tcggaaatga ataacatctc cgtcttggac 3357901 cacatattct ttcccttcaa ggcggacttt tcctgcctct ttagctcctg ccataccgcc 3357961 gcccgcaaga agatcctcat aagcaactgt ctcagcacga atgaagcccc gctcaaagtc 3358021 actatgaata attcctgcac actcaggggc tttcatgcct tttttgaatg tccaagctct 3358081 gacttcctgt tctccggctg tgaaatatgt tgcgaggccg agaagagagt aagacgcttt 3358141 gatcagctga tcaagacctg attcttgaat gcccagctct tccaagaaca tttgcttttc 3358201 ttcgccttca agctcagcga tttcagattc gatttttgca cacacaacga taacttctgc 3358261 gttttcgccg gcagcgtact cgcgaatctt cgctacattt tcattgccag atggatcagc 3358321 aacttcatct tcacttacgt tggccacgta caaaataggc ttcgaagtca gtaaatggag 3358381 ctgcttcaca agcttttgct gctcttcagt gaattctaca gatcgagcag gcttttcact 3358441 ctcaaacgct tctttcagtt tagataaaat ctcaaactca aatacagcgt ctttatcttt 3358501 ttgcttcgca agcttgctga cgcgtgtaat ccgcttttca actgtttcca tatcagcgag 3358561 gatcagctca aggttgatcg tttcaatgtc atcaatcgga tcaacctttc cggaaacgtg 3358621 tgtaatgttg tcatcggaaa aagcacggac aacgtggcaa atcgcgtcaa cttggcgaat 3358681 atgagatagg aacttgttgc cgagtccttc tcctttagat gcgcccttta caatccctgc 3358741 aatatcagtg aattcaaaag cagtcggcac agtcttcttc gggttgacca gctcagtcag 3358801 cttttgcaga cgatcatccg gcacctctac aattcccacg ttcggatcaa ttgtacagaa 3358861 cgggtagttg gctgattcgg caccggcctg tgtaattgcg ttaaatagtg ttgattttcc 3358921 gacgttcggc aaaccaacaa ttccagctgt taaagccatt ctttcatctc ctctatataa 3358981 aaccgtcatt gtatgaacgt attttgaacc tagagcaatt ataaggaggt tcactggaaa 3359041 agacaagctg acaaaaaagc attttcagct tgccaatccc tttgattatg cttttttcaa 3359101 gcctactaaa cagtcaaaaa gcgtacttcc cattccatta tcagaatttg tatcatttgt 3359161 cagtgcattg actgaccctc caaaagccgc ccacatgcct tcatctatat taatcgtctt 3359221 cgcatgagcc tgcttcatca ctttcacctt gcccttcatg cttccgcggt cattaaagat 3359281 gacaacttcg tctccatcct gaagatcctg cccagccgct atatctggag aaatatcgac 3359341 ctgaacgtgc tgaagctttt caataaacgg cacatgctgt gaatgattgg aacgctgcgg 3359401 atgaatggat aagagcgtat aagggtactt tccagctaac tcctcattat ggaaaacaga 3359461 ttcttcgggc acatttaatt gaagcgagcc gctaaatcct ttttgctcag ctagcgacga 3359521 agtaaattca aattttccac tcggcgtcaa aaactgataa tcatcccacg gcacctgttt 3359581 tactggaaga gggaggtggc ctttttcttt taaacgctca agtgtcacat cctctgcttc 3359641 caatgaagaa agccccatct ctaaaaattc ttgagtgctg tattcaaaca gctcgccaaa 3359701 cccaagacgt tttgcaagct ctgaccagat ccagctgtcc gatttcgctt caccctgcgg 3359761 ctccacaagc ttcttcccgt actgaacata atgatgatac atactggaat agtagatatc 3359821 ttcttcttca aaaacagtgg cagtcggcaa aacataatca cacagctctg cggtatccgt 3359881 cataatggaa tcaatcgcga ccgtcattgg aaccttttca aatgcttgtc tcaccttatt 3359941 tgtattcggc acctgagtca gcggatttcc gcacgtcaca ataatcatct caatcgcagg 3360001 atcagcagcg gtcaacactt cttcagcctg tgtcatcatt gaaaaagaac gggatgttgt 3360061 ttttaattcc ggcagcgtca gctttgtttt tgcaaagctc tcaccaatct ggacatttcc 3360121 gaaattcgcg ccgccgccct taattccgac atttccgctt gccgccacaa gtgcatcaat 3360181 ccaacgaatc gttcccccgc cgtttttata tcgctgcatg ccaagcccca taaaagtaga 3360241 caccggacca tcagcataca aacctgccaa atactccagc tcctccatag aagtttctgt 3360301 tttcacaata aactcttcca gagaaacggt cttcaaaagc tctttcacat catcaaaacc 3360361 gacagaatgc tcagaaataa acgtttcatc cgttcttccc atctcaatca gaaccttcaa 3360421 aacggctgcc gcaagccagc cgtccattcc aggctttaca gagatatagc ggtcggcaag 3360481 cttagcagtc gggttgaaga tcggatcaat caccgtaatc gtggcgccct tctttttcac 3360541 ctgctgcaag tgatggtata agtgcatatt tgttcttgat acatttcttc cccacacaac 3360601 aacatgcttg ctgttgtaaa tatcaagcgg tccgtgaccg tacgaacggc caaaatccca 3360661 gctttgcgcc tcgataccgg agccccagca tatgcttccg acgatttcgg tcacgccgcc 3360721 atatccatta aaaaaacgct gatcaagcgc ttttaacaga ccgttattcg cataatcatg 3360781 gctgtgcaaa acagcagtcg tctccgacgt ttccttgatt tcccgaagtt tatcggcaat 3360841 ttcatcaagt gcctgctccc aagaaatccg cacaaactcg ccattttgtt ttttcattgg 3360901 atagcgaagc cgatcaggcg aatttgtttt tgtctcaagc attctgccgc ggccgcagat 3360961 tttaccttcc gtaatcggat ggtttggatc tccgtccact tttgttacct ttccatcatc 3361021 aacagtcacc aaaaagccgc agctgtccca acaattcagc ggacatgccg actgatgcac 3361081 tttgctcatc gccgtcttct ccttaccttc tatatgaaaa agcatgagtg tcggcctatt 3361141 tatgaagtag gctcctcatg cttgactagt acttttttta gttttctttc aaattctctt 3361201 ctcggaatca taacactgtg agagcatccc tcacacttaa ttcgaatatc cattcccatg 3361261 cgtataattt tccagctgtt cgctccgcat ggatgcggtt ttttcatttc tacgatatca 3361321 ttcaggccaa agtctttatc cgccaagacc cttcacctct tttcctaaac tgctgtatct 3361381 attgtacaaa aaaactgatc ataagagcaa tcaagatacc cgaaaagaaa tacatcctct 3361441 tatttccatt tactcaaaat aggatataag agcagacaaa ctaacaaata caaattgagc 3361501 atcccatata tcggatacaa gaacgcgatc aaatcagaaa atccgaaaga agtaaaaggt 3361561 accattaaca ctaacaaaat caacacaatc atccatctcg gcatatgaat aaacgccatc 3361621 agccggctgg acaaacccag caaaccagct accgtcgtcg tgtaaatcgc caggcacagc 3361681 accgccgtca tacataaaaa aaggaaataa ggcgcaccct ccagaacggc aaacagcggt 3361741 atttcaaact gagaaaggga gcccgccagc tccaccaacg tttcattata aacaaatgag 3361801 atcacgccaa aaataagacc gcttgccaca cttgcgattt ttgcttctcc gagccctttc 3361861 atctctttcc caacagagga taaaatcgca acaactgaaa ggatgtttaa agaggtaaac 3361921 gtaatgctcg caggccagtt atactgctgg gacaaatcaa tcgtccacgt atggtgatgt 3361981 gtgctctgaa aggagatcag cgcatataaa agccccgcta ctaacacagg aatcaaaata 3362041 ctatttatag ataatattcc tttcacatcc cacaaaaaca agcacactgt cacgatgcaa 3362101 atcagcgtga ttccccacca gaaaggaagc ttgtacattt gcagggtcac accgcctccg 3362161 gcaatcatca ccatagtcgt cgaaaacaaa taaaaaatga tgaggacatc ataaattttc 3362221 gccagccatg gccccattaa atgctccaga accggcagaa aatgagtgga ttgaacctta 3362281 aaactgattt tcatcacaat ataagacgag aaaatgaaca taattgtaaa cagcacaata 3362341 gcaagtccgc tttccgcccc aaaaaactgc catatctcct gaccgctcgc atatccggcc 3362401 ccgatcaggc tccctaatat gagcagcatc cacttcattc cggctctcca caacactatc 3362461 acctcataga caaagttcag cttgttcccg ttattgttac tatataaata aaggaaagca 3362521 aacatgccat attttcatag acatttgaac acaagctgaa attatcatac gaaatacaca 3362581 taaaaaagac tgctaatacg gcagtctaaa aagagatatt tatttgtttg tccgcggaat 3362641 gaagaagtga acttcactct tcactttttt ctaaccattc ctacctattc aagtgtttca 3362701 taagcagacc attgcttgat catgatcgag gcaatggggg acaatacttg taatcgccca 3362761 ctaaccattc atatcatgcc ctctactttt ttaaaatctc tggtgccata cacaaagcat 3362821 aaaaaatcat actgctggat atactgtaaa caaccttaca taactacaca caccatagca 3362881 attctgttac ctactataac aaggaagtga aacccatgaa tcgaaaaggc gggctttttt 3362941 cttctcagga acgagtaaag caatatgttt cacatacaga tgctgcagcg gcaaaacaaa 3363001 tccaaaccat cctttcttca tccttacgta aagctgctgg caaaccaatt gtcgtggttt 3363061 gtatcggaac agaccgttca accggtgact cattaggccc gctcgtagga atgaaactca 3363121 aacagatgca gctcaccaga ttccatgtct acggaacctt atctgacccc gtccatgctg 3363181 tgaacatgaa ggataaaatc aatgacattc ataaattaca taaaaaccca tttgttatag 3363241 cagtcgatgc atgcttaggc cgcgttaaga gtgtgggttc atttcaaatc ggggacgggc 3363301 cattaaagcc cggagccggt gtacaaaaag accttcctga agtgggagat cttcatatta 3363361 acggaatcgt gaatgtgagc ggttttatgg aatattttgt attgcaaaat actagactca 3363421 acttggtcat gaatatggca aatgttctag cggaaggttt gagtttaaca gatcggacag 3363481 agtggaggca agaacgcctt aacccgttgc aaaggctcac tgggcgcata taaaataaaa 3363541 accatcttcg tttgaaagat ggttttttca tttatgattc tcgttcagac aaaagctcta 3363601 aaatccggtc aaggtcttca ttagagaaaa attcaatttc gattttgcct tttttcttct 3363661 gtcttttaat attaactgtt gttccaaaat aattttggag ataggattcc cgttctttta 3363721 gaaccgcatc tttcacaggt tcttttttct ttgtttcacg tggaacattc tgattcaact 3363781 gctgaatcag ctgctcaagt tggcgaacat tgagctgctc cgcaatcact ttttgtacca 3363841 gcggttcaag cttatttttg ttttttaagc caagaagcgt gcgtccatgt cccatagaaa 3363901 gcgtgccttc ggcaataagc tgttgaatat tttctggcag tgtcagcagt cttaaatgat 3363961 tcgcaatatg cggtctgctt ttcccaagac gtttggcaag ctgctcttgt gtgagatcta 3364021 agtgtttcaa aagggagtca tatgcctgag cctcttcaag cggagataaa tcttcacgct 3364081 gaaggttttc taataaagca atttccctca ttaacgcctc tgataattca cggacaatgg 3364141 ccggaactgt atctaaacct gccagctttg ccgctcgaaa acgccgttca cccgcaacaa 3364201 tatcatagcc ttttaaagat tttctgacga taagcggctg aagaatgcca tgctgcagca 3364261 cagattcttt tagttcagct aatgcctcgt catcaaagtg ttttcttggc tgataaggat 3364321 tagggcgtaa atcggcaatt ttaatttctt caactgtctc ttcagacaaa tctacctgat 3364381 taaataacgc attaatccct tttccaaggc ctttagccat tcgcagccac ttcctttgct 3364441 aaatctaaat atacttccgc acctcttgac cgcggatcgt ataaaatgat gggttttccg 3364501 tgactcggtg cctcactcag acggacatta cgcggaataa ctgtcttata tactttatcc 3364561 ctaaaatact ttttaacctc ttcaatcact tgaatgccaa ggtttgtccg ggcatcaagc 3364621 attgtcagca atacaccttc aatcattaaa tcagtattca aatgcttttg cacaagacgt 3364681 actgtattta ataactggct gagaccctcc aaggcataat attcgcactg tacaggaatc 3364741 acaacggaat ccgaggcagt aagggcatta atcgtcagca agcccaatga cggcggacaa 3364801 tcaatgataa tataatcata attttgcttt actgcttcaa gcgctctctt caatctcact 3364861 tctcttgata ttgtaggaac cagctcgatc tcagcccctg caagctgaat cgtcgcagga 3364921 atcacatcca agttctctac tgtcgttgct ttaataatat ctattacatc tgcatcatct 3364981 actaaaatat cgtacacaca ctgctctaca tcggcttttt caatccctaa tccgcttgtc 3365041 gcatttccct gcggatcaat atctaccagc agaacccttt tccctatgta agccaaacat 3365101 gccccaaggt tgacagacgt cgttgttttg ccgaccccgc ctttttggtt cgtaattgct 3365161 atgatttttc ccacgatgtc acctactttc acatgaacat gtactatctt gcttctattc 3365221 tatcaaaaaa agattaaagc gtttcatttt tttcatcatt ttgttccgaa tcagaaggga 3365281 aataattgaa aattcaagca cgctttatgc tttctcttat aaattctgca atttctatgt 3365341 ttttttgact taaaaaagga atttcttaaa gaaaaaaaga agaagtcaca gtacagaacg 3365401 tggaaacagg atggtgagaa aatggtttat caaacgaaga gagatgtacc cgttacgctg 3365461 atgattgtgt ttctcatatt actgatacaa gcagatgcca ttgttccttt tgtgctggga 3365521 aatatgagag tttccggctg gatcattttt attctgctga ctcttttaaa tggactcatc 3365581 atttggagct ttattgacct aaaatatgta ttgaaggaac accatctgat cattaaagcc 3365641 ggattgatca aacatcaaat tccttatgaa aacatcgata aagtcgttca aaaaaagaaa 3365701 ctatggtccg gttttcgtct gatcggctct cgccatgcca tcacaatata ttatcagggg 3365761 ggatggggac atgcagtaat ttcaccgcaa aaatctgaag aatttatcca caagctcaaa 3365821 gaaaagaatt ctaatataat aatattcact aaaagtaagt gattaccttt tgttaaaaat 3365881 ataaaaagct ctcctgcttt tcaggagagc ttctattttg gtatgcgaat cgttaattga 3365941 atatattctt caaattcttc ttcttccgta ttcaatttta caccgctgtc ttccaccatt 3366001 gatagtgact ggcgaatcgt gttcatcgca attcttgtat ctctgctgaa tgctttgcgt 3366061 ctcggctttg gctttctctg gccttgctcc agcattttca ccacgcggtc ttctgtctgc 3366121 tttacattta aacttttctc aataatctct gtgagcagtg tgacttggag ctcaggctgt 3366181 ttcagcggaa tcagtgctct ggcatggcgc tcggtgattt tcttctccat aatcgcctct 3366241 tggaccggct gaggcagctt taataaccga agcttattcg cgattgtaga ctgccctttt 3366301 cctaagcgct gtgcgagtgc ctcctgtgtt aaatcatgca gctcaagcag cctagcataa 3366361 gcatgcgctt cctcaataga agacagttct tcccgctgca agttttcgat taacgccaca 3366421 gaagcggttt ccgtgtcgga aaaatcctta ataattgccg gaatcttttc ccactcaagc 3366481 gattgcaccg ctctccagcg tctttcacct gcaatgagtt cgtattggcc ttcttcttct 3366541 gtatgcctaa caacaatcgg ctgaataatg ccgtgtgtat gaatggtcat tgctaactct 3366601 ttgatttttt catctgagaa aatggtgcgt ggctgaaaac ggttgggaac gatagcattt 3366661 accggtattt ccagaatctc ttctttgttt gtatcatgtt cagcaatctc cggctcctgt 3366721 tccttctcac caagcccgaa gaaacgagag aatgaatgct tcatgtacct acaccacctt 3366781 taaaaactgc catttttata attctatttt ctcatggttt ttcctgctgt acatccatca 3366841 attttgatga aaatatgatg gtattgtcat atcaggctgt ctaaattacc cttcaattgg 3366901 cgatttatta ggagttcccg gttttcttgg atacttctta ggtgtatttt ttattttgcg 3366961 tatcaccata atattacgat cgctttcttc aataggcagc ttaaaagaat ggatattctc 3367021 aagttctcct ccaagcgtcg tgattgcttt tttgcctgca ttcagttctt cttcagctga 3367081 tgcggctttt aaagcaacaa ataaaccgtt tttcttcacc agaggcaagc aaagctcact 3367141 caaaacagat aatctcgcaa ctgcgcgcgc cgtcacaata tcatagcttt cacgcacgtc 3367201 tttccgttgc ccgaacgttt cagctctgtc atggcagaat gttgtattct ccaattgcaa 3367261 agcttcagac aacttttcta aaaacgtaat ccgtttgttt agtgaatcca cgattgtgac 3367321 atggaggtgc ggaaagcata tttttatcgg cagacttgga aaacccgctc ccgctccaac 3367381 atcacaaatc gtgttcacct gattgaagtc gacataaaaa gcagctgtaa tggaatcata 3367441 aaaatgcttt aaatacactt cttttttctc tgttattgaa gtcagattga ttttttcgtt 3367501 ccattcaacc agcatgtcgt aatacagctc aaattgctcc agctgacggg gagaaaggga 3367561 gatccctttt tccgccaaac cagaagtgaa ttcttcaata ttcatgccgt catcctttct 3367621 actcggctat cttcgcaatg cgtccctgct ctaaatacac caatagaatt gaaatgtccg 3367681 ccgggtttac accggaaatg cgggaagcct gggcaacaga caaaggccgt acatttttca 3367741 gtttttgacg cgcctcggtc gcaatcccct taattgcgtc ataatcaatt cggtctggaa 3367801 tttttttatt ttccatcttc ttcagttttt ccacttgctg aagagatttt tcaatatatc 3367861 cttcatattt cacttggatt tctacttgtt ctgccacgtc ttgaggaacc ggcacttctg 3367921 gcggcgccag ttttgtgact gtttcatagt tcatttcagg acgtttcatc aagtctgtgc 3367981 cgcgaactcc atctttcaat tcgcttccgc caagagaacg gatatattct tgattttccg 3368041 gagacggctt gataattaca gaatgaagac gttttttctc cgcctcgatc gccgcttttt 3368101 tcttctcaaa agccgcatag cgctcatcag aaatcaatcc aatgcgatgt ccgatttctg 3368161 tcagacgcaa atcagcattg tcatggcgaa gcagcaatct gtattccgca cgtgatgtca 3368221 aaagacgata tggctcattg gtaccttttg tcacaaggtc atcaatcaga acaccaatat 3368281 aggcgtcaga acggcttaga attacttctt cttttccaag cgcttttcgt cctgcattga 3368341 ttcccgccat aatcccttgt cccgcagctt cttcataacc ggatgttccg ttaatttggc 3368401 ctgcagtata aaggtttgtg atttttttgg tttcaagtgt cggccatagc tgtgtcggta 3368461 cgattgcatc atactcgatc gcatagccgg ctctcatcat ttgcacgttt tcaagtccag 3368521 gaatcgttgc aagcattctt tgctgtacgt cttctggaag acttgtagat aaaccttgga 3368581 catagacttc ctgtgtattt ctgccttccg gctcaaggaa gatttggtga cgcggtttat 3368641 cattaaaacg gacaactttg tcttcaatgg atgggcagta tcttgggccc gtacctttga 3368701 tcataccgga atacatcggt gaacggtgca ggttgctgtc aataatctca tgtgtctcag 3368761 ggcttgtata tgtcagccag caagggagct gatctgtgat atattccact gtttcatatg 3368821 agaaagcgcg aggcacatcg tcaccaggct gaatttccgt tttgctgtaa tcaatcgtgt 3368881 cgcttttaac gcgaggcggc gtacctgttt taaaacgaac aaggtcaaaa ccgagttcct 3368941 ccaaatgctc agaaagctta atagaaggct gctggttatt cgggccgctt gagtaagaca 3369001 gatcgccaag aatgatacgt cctcttaaat atgtccctgt cgtcatgaca actgctttcg 3369061 cacgataatg tgcgcctgtt tgtgtaataa cgcctcggca ttcgccgtct tcaacgatca 3369121 gccgctccac aattccttgc agcaatgtta agtttggttc tttttcaagc gtatttttca 3369181 tttcgtgctg atattggaat ttgtctgctt gcgcacgcaa tgcacgaacc gcaggacctt 3369241 ttcctgtatt cagcattctc atttgaatat gtgttttatc gatgtttctt cccatttctc 3369301 cgccgagcgc gtcaatttcg cggacgacaa tcccttttgc ggggccgccg acagacggat 3369361 tacatggcat aaatgcaacc atatctaggt tgatggtcaa gacaagcgtt ttggcgcctt 3369421 ggcgtgcaga tgcgagggca gcctcaacac cggcatgccc ggcgccaatc acaatcacat 3369481 cgtattggcc tgcttcatac cccatgattc tagttcctcc tttaattatt ttcctaaaca 3369541 gaattgagaa aagagctgat caattaagct ttcgtggaca gaatctccaa tgatttcccc 3369601 taaaagctcc cagcatcttg taaggtcaat ttgcaccatg tcgatcggga catcctgttc 3369661 gatgccgcta agcgcatctt caatggcgcg ttttgcttgc tgtaaaatag tgatgtgacg 3369721 tgtgttgctg acataagtca gatcaccgct ttcaatggca cccgtgtaga acagtgattg 3369781 aatcgcttct tccagatcat tgatgccttc ctcttttaaa agagatgtcg taacaactgg 3369841 acgtccattg gcaagctcac ggacacgttc agtgtcaatc ttcggctcaa ggtcagtctt 3369901 attcaaaatc acgataacat ccatgccctc aacggcttca aaaagcttca cgtcttcttc 3369961 agaaagctct tcactataat taagcacaag taaaatcagg tccgcttcct ttaggacctg 3370021 gcgagaacgt tcaacaccga ttcgctcaac aatatcctct gtttcacgaa tacctgctgt 3370081 atcaaccaga cgaagcggaa cgccccttac attcacgtat tcctcaatca catcccgtgt 3370141 cgttccggga atatcggtta caatggcttt tgcctcatga acgaggctgt tcagaagaga 3370201 tgattttcct acgtttggcc ggccgataat gacggtagaa agaccttcac gcaagatttt 3370261 tccttgctca gaagtcctca gcagcgtctc aatttccttt ttcacggcgg ttgccttttc 3370321 gactaaaatc tgatgcgtca tttcctctac atcatcatac tccggataat caatattcac 3370381 ctcaacatgg gccagtgttt ctaaaatctc actgcgcaaa cggcgcacca aagcagaaag 3370441 acgcccttcc atttgattca tagcaacgtt cattgcccgg tccgttttcg ctctgattaa 3370501 gtccataacc gcttccgcct gtgaaagatc gattcggccg tttaaaaacg cacgtttcgt 3370561 aaattcacca ggctctgcca gtctcgctcc ctctctcaat gcaagctgaa gcacttggtt 3370621 cacagtcaca attcccccgt gacagttaat ctcgatgaca tcttctcgtg taaaagttct 3370681 cggcgctttt aacactgata ccattacttc ctcaacgaca cgatccgaag gtctgtctac 3370741 gatatgacca taatgaatcg tatgtgattc gaccgagctg agtgttttcc ccttcggtcc 3370801 cttataaatt ttatctgcga tttgaatggc ttctggtccg ctcaaccgta caatcgcaat 3370861 cgcgccttct cccatcggtg tggaaattgc cgcaattgta tccatgttgt tcacctctct 3370921 ttacttatac ttcatctata taaaaaaatt tttattatgc caaaactaaa agataacata 3370981 gtttggttcg aagtggaaga tttgttatcc acagaaatag aaattcgtcc cttattactt 3371041 taacttatcc acatgtgaat aacaattaat tttatttcct gaacttcctt tttatcaaca 3371101 ggatacacct aaaaagaaaa aacttaaacg gcaaaacctt gatattacta ggaaaagtag 3371161 atttttcgga tacaaaaaaa ccgaaatcca atttttatcg gacttcggtt ttatgctatc 3371221 ttttatggga aataacgaga tgacgatttt cgccttcacc cattgaatat gttttgatct 3371281 ggtggtttgc atatccagaa agagtatcgt gaataatttt tctttcgctg gacggcatgg 3371341 gctcaagctg gatggatttt ttcgttttca aaacctggtc agcaagcttg atggccagct 3371401 ggctcagtgt ttcttttctt ttcaaacgat agttttctgc atccaccgtc acatttttat 3371461 attggcctgg ataacggtta agggcaagct gtgtcaaagt ttcaagggcg tttaaagttt 3371521 gtcctctttt cccaatcaac aatgctgcct tttcacctgt tatatgatat ctcactgtct 3371581 ttttgctttc ttgaacagtc acatcagact tcccggcaat ggcttcggca atcgtttgaa 3371641 gatataactt cgcttgctga atcggatcaa tcttttcaac cagctttacg atcgcaggct 3371701 ttttaccgaa aataccgaga aaccctttgt ttccctcttc aataacagta atttctacct 3371761 tatccttcgt taatcccaac tcttgcaatc cggactgtac tgcttcatcg acatttcgcc 3371821 ctgcagcagt cacattcctc actttttctt tcctccggct ttttgcggct caggattttt 3371881 tttaatatca ggtcctttaa tgaggaaagt ttgcgcaatc ataaacaagt taccaactac 3371941 ccaataaaga gaaagagccg ccgggaagtt gatcgcaaat acgataatca taattggcat 3372001 aatccaaagc atcatcgcca tttgcggatt ttgctgcgca ttgccagcca tcatcagttt 3372061 ttgctgaaca aatgtagcga caccggcaac gataggaaga atatagtaag gatctttttc 3372121 tcctaagtca aaccataaga agctatgctc tgaaatcgcc tgggttctca tgatcgcatg 3372181 atagaatcca attaaaatcg gcatctggat caaaatcggg aaacatcccg ccaatggatt 3372241 gacaccatgc ttttggaata aagccattgt ttcctgttga agcttttgct gcgttttttg 3372301 atcctttgag ctgtattttt ctttaagctt ttgcatttcc ggctgtaaag cctgcatcgc 3372361 tttcgaactt ctcagctgct taatcatcag cggtaaaatt aataaacgaa ttaaaatggt 3372421 aactagaata attgaaagcc cgtagttatc tcccgtcaat ttcgctacat acgtaatgag 3372481 ctcagacaat ggatatacta cgtacttgtc ccagaaatgc ggactatctg cagtgatcgg 3372541 ctctttcaca ctcgagcatc cagccaaaag catgaatacg ccaaccatac ttaatagcaa 3372601 ccctattctc cttttcaaca acatttcctc ctataattaa tctttacact cttttattgc 3372661 aaagcatact tgtatgtatt ttagcatctt tcagttttaa atggtgtctt tttctgatca 3372721 accagaaagg aagcgctttt aaaagttgta agaaagcagt ggtgatgcct actttgacga 3372781 agatttctta tataatgaag actttctgaa tagatgctgc agactttttt tcgtttcctc 3372841 atatgtcagc tggctcgccg gttttctggc aataatgatg taatcctttt ccttcagtct 3372901 ctctttctct tcaagaaagg cctgccgaat caaacgtttg atccgatttc gcatcacagc 3372961 attgccaatt tttttgctga cggaaagccc gacacgcagt tcatcatttt caggctgatc 3373021 aagcgtatat aagacaaact ggcggtttgc aactgatgtc ccatgtttaa acactttttg 3373081 aaaatcttca tttttcttta aacgatttcg cttcttcaaa tgactcactc cgatactggc 3373141 tggcagaaac ttttaaaatt tattatgaac atgagatgca tctgaaccag gaagcatgcc 3373201 ccggttcatt acgcatcaca tctatctttt cccataacgt gaaaaaagac cactgacatt 3373261 attcagtggc ctaagctgat aatacttttc tgcctttgcg gcgacggcgt gctaaaacta 3373321 gacgaccgtt ttttgaactc atacggcttc tgaagccatg aactttgctg cgtttacggt 3373381 tattcggttg gaatgttctt ttcatttatg acacctccct cgaggaatag ctgttaaaga 3373441 cagtcttact tattatattt gcgttaccta ttcattgtca acttcactag tgcttttatt 3373501 tcttgcaacc ataataggat accatacctt ttcaactttc gaaaccttat tttttagatt 3373561 ccttaatttt acggaaaaaa gacaaattca aacaatttgc ccctaaaatc acgcatgtgg 3373621 atatcttttt cggctttttt tagtatccac agaggttatc gacaacattt tcacattacc 3373681 aacccctgtg gacaaggttt tttcaacagg ttgtccgctt tgtggataag attgtgacaa 3373741 ccattgcaag ctctcgttta ttttggtatt atatttgtgt tttaactctt gattactaat 3373801 cctacctttc ctctttatcc acaaagtgtg gataagttgt ggattgattt cacacagctt 3373861 gtgtagaagg ttgtccacaa gttgtgaaat ttgtcgaaaa gctatttatc tactatatta 3373921 tatgttttca acatttaatg tgtacgaatg gtaagcgcca tttgctcttt ttttgtgttc 3373981 tataacagag aaagacgcca ttttctaaga aaaggaggga cgtgccggaa g //